ANGEW - 4894

• (2025). Frontispiece: Cyclochlorotine hydroxylase CctR reveals DUF3328 as a family of copper-dependent metalloenzymes. ANGEW, 64(38), e202583802. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583802}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202583802}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Cyclochlorotine hydroxylase CctR reveals DUF3328 as a family of copper-dependent metalloenzymes}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Elucidating ligand exchange dynamics of hexacyanochromate-based redox mediators in aqueous iron-chromium redox flow batteries. ANGEW, 64(38), e202583801. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583801}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202583801}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Elucidating ligand exchange dynamics of hexacyanochromate-based redox mediators in aqueous iron-chromium redox flow batteries}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Chirality makes or breaks chemically driven self-assembly (Angew. chem. int. ed. 38/2025). ANGEW, 64(38), e202518660. (www)

  @article{ , archive = {J_ANGEW}, author = {Lenard Saile and Kun Dai and Mahesh D. Pol and Thejus Pramod and Ralf Thomann and Charalampos G. Pappas}, doi = {10.1002/anie.202518660}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202518660}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Chirality makes or breaks chemically driven self-assembly (Angew. chem. int. ed. 38/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Multisite proton-coupled electron transfer facilitates oxidative photocatalysis in a molecular zr-based coordination compound (Angew. chem. int. ed. 38/2025). ANGEW, 64(38), e202518413. (www)

  @article{ , archive = {J_ANGEW}, author = {Mercedes Moreno-Albarracín and Alvaro M. Rodriguez-Jimenez and Omar Nuñez and Pablo Garrido-Barros}, doi = {10.1002/anie.202518413}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202518413}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Multisite proton-coupled electron transfer facilitates oxidative photocatalysis in a molecular zr-based coordination compound (Angew. chem. int. ed. 38/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Metastable macrocyclic bis-meisenheimer adduct (Angew. chem. int. ed. 38/2025). ANGEW, 64(38), e202518392. (www)

  @article{ , archive = {J_ANGEW}, author = {Simon Pascal and Angélina Torres Ruiz and Aerin E. Baker and Douglas A. Vander Griend and Michel Giorgi and Aurélien Planchat and Denis Jacquemin and Olivier Siri}, doi = {10.1002/anie.202518392}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202518392}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Metastable macrocyclic bis-meisenheimer adduct (Angew. chem. int. ed. 38/2025)}, volume = {64}, year = {2025}, }
• (2025). Cathleen zeymer. ANGEW, 64(38), e202516730. (www)

  @article{ , archive = {J_ANGEW}, author = {Cathleen Zeymer}, doi = {10.1002/anie.202516730}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202516730}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cathleen zeymer}, volume = {64}, year = {2025}, }
• (2025). Zhengyang bin. ANGEW, 64(38), e202516631. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhengyang Bin}, doi = {10.1002/anie.202516631}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202516631}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zhengyang bin}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Synthesis of gold hydride at high pressure and high temperature (Angew. chem. int. ed. 38/2025). ANGEW, 64(38), e202516225. (www)

  @article{ , archive = {J_ANGEW}, author = {Mungo Frost and Kilian Abraham and Alexander F. Goncharov and R. Stewart McWilliams and Rachel J. Husband and Michal Andrzejewski and Karen Appel and Carsten Baehtz and Armin Bergermann and Danielle Brown and Elena Bykova and Anna Celeste and Eric Edmund and Nicholas J. Hartley and Konstantin Glazyrin and Heinz Graafsma and Nicolas Jaisle and Zuzana Konôpková and Torsten Laurus and Yu Lin and Bernhard Massani and Maximilian Schörner and Maximilian Schulze and Cornelius Strohm and Minxue Tang and Zena Younes and Gerd Steinle-Neumann and Ronald Redmer and Siegfried H. Glenzer}, doi = {10.1002/anie.202516225}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202516225}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Synthesis of gold hydride at high pressure and high temperature (Angew. chem. int. ed. 38/2025)}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed asymmetric [2 + 2 + 2] cycloaddition of diynes via vinyl cations. ANGEW, 64(38), e202514641. (www)

  @article{ , abstract = {Catalytic asymmetric [2 + 2 + 2] cycloaddition of diynes represents an efficient and atom-economical strategy for the assembly of valuable chiral cyclic targets in a single step. However, this strategy traditionally relies on the cyclometallation process. Moreover, there are no versatile asymmetric [2 + 2 + 2] cycloaddition methods for diynes that are compatible with C─C double/triple bonds and C─X double bonds. Here, we disclose a copper-catalyzed asymmetric [2 + 2 + 2] cycloaddition of diynes via vinyl cations. This universal [2 + 2 + 2] cycloaddition is suitable for the asymmetric cycloaddition of diynes with various C─C double/triple bonds and C─X double bonds, leading to a range of valuable chiral hexahydropyrrolocarbazoles, tetrahydropyrrolocarbazoles, and tetrahydropyran[4,3-b]indoles in generally excellent yields with excellent diastereo- and enantioselectivities. Importantly, this protocol features the first asymmetric [2 + 2 + 2] cycloaddition via vinyl cations, and constitutes the first construction of carbon stereocenters in triyne cyclization.}, archive = {J_ANGEW}, author = {Yan-Xin Zheng and Li-Gao Liu and Yu-Yao Zhou and Shu-Ya Yang and Xin-Qi Zhu and Xin Hong and Bo Zhou and Long-Wu Ye}, doi = {10.1002/anie.202514641}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202514641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed asymmetric [2 + 2 + 2] cycloaddition of diynes via vinyl cations}, volume = {64}, year = {2025}, }
• (2025). Fluorescent three-dimensional covalent organic frameworks with pcu topology based on triangular antiprism node. ANGEW, 64(38), e202514285. (www)

  @article{ , abstract = {The design of highly connected fluorescent polyhedral building blocks is essential for expanding the structural and functional diversity of three-dimensional covalent organic frameworks (3D COFs) but remains largely underexplored due to synthetic and characterization challenges. Here, we report a hexatopic fluorescent building block with triangular antiprismatic geometry, developed via steric-hindrance-directed conformational control and the integration of triphenylamine units. Its imine condensation with linear diamines afforded two crystalline 3D COFs with unambiguously resolved 6-fold Class IIa interpenetrated pcu topology, as determined by continuous rotation electron diffraction. Interestingly, both COFs exhibit yellow-green solid-state fluorescence and high-contrast piezofluorochromism under hydrostatic conditions. This work introduces a new class of fluorescent polyhedral nodes to expand the structural diversity of fluorescent 3D COFs and highlights their potential as stimuli-responsive materials for interesting applications.}, archive = {J_ANGEW}, author = {Sheng Yin and Lin Li and Jiang Han and Ya Zhang and Yongyong Wang and Yuanpeng Cheng and Xu Zhou and Bo Gui and Zewei Quan and Junliang Sun and Cheng Wang}, doi = {10.1002/anie.202514285}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202514285}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorescent three-dimensional covalent organic frameworks with pcu topology based on triangular antiprism node}, volume = {64}, year = {2025}, }
• (2025). Bicyclo[1.1.0]tetragermane-2,4-diide diradicaloid. ANGEW, 64(38), e202513772. (www)

  @article{ , abstract = {The synthesis, structure, and reactivity of the bicyclo[1.1.0]tetragermane-2,4-diide compound [(ADC)Ge 2 ] 2 ( 3 ), which features a Ge 4 core bridged by two anionic dicarbene frameworks (ADC = PhC{N(Dipp)C} 2 ; Dipp = 2,6-iPr 2 C 6 H 3 ), are reported. Treatment of an alkyne-functionalized amidine Me 3 SiC≡CN(Dipp)C(Ph)═N(Dipp) ( 1 ) with GeCl 4 affords [(ADC)GeCl 3 (GeCl 4 )] ( 2 ). KC 8 reduction of 2 yields 3 as a Venetian red crystalline solid. DFT calculations reveal a singlet ground state for 3 with the singlet-triplet energy gap of 14 kcal mol −1 . CASSCF (complete active space self-consistent field) calculations suggest a modest diradical character (β = 9%) for 3 . Compound 3 readily reacts with TEMPO (2,2,6,6-tetramethylpiperidinyloxyl) to yield the Ge─Ge bond-cleaved product, [(ADC)Ge(Ge-TEMPO)] 2 ( 4 ). Treatment of 3 with Fe 2 (CO) 9 gives [(ADC)Ge(Ge{Fe(CO) 4 })] 2 ( 5 ) .}, archive = {J_ANGEW}, author = {Falk Ebeler and Yury V. Vishnevskiy and Jan-Hendrik Lamm and Beate Neumann and Hans-Georg Stammler and Rajendra S. Ghadwal}, doi = {10.1002/anie.202513772}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bicyclo[1.1.0]tetragermane-2,4-diide diradicaloid}, volume = {64}, year = {2025}, }
• (2025). Exploring coupling-derived a′-site cations for crystallization delay and defect passivation in quasi-2D perovskite light-emitting diodes. ANGEW, 64(38), e202513755. (www)

  @article{ , abstract = {Despite quasi-2D perovskite light-emitting diodes (quasi-2D PeLEDs) having shown great potential in the fields of light emission and display, the uncontrollable crystallization processes and substantial defects of perovskite emissive layer still limit their further development. Herein, we reported the design and in-situ synthesis of A′-site cations with oxygen–phosphorus–nitrogen–carbon (O─P─N─C) frameworks in perovskite precursor solutions by incorporating diphenylphosphinic chloride (DPCl), a bifunctional molecule containing both P─Cl and P═O functional groups. The P─Cl groups undergo nucleophilic substitution reactions with the ammonium terminals of formamidinium (FA + ) and phenethylammonium (PEA + ) cations, yielding large A′-site cations that regulate crystallization kinetics during spin-coating. Concurrently, P═O groups coordinate with undercoordinated Pb 2+ ions at grain boundaries, passivating defects. This dual-functional mechanism synergistically optimized crystallization dynamic and suppressed non-radiative recombination, resulting in compact, low-defect perovskite films. Owing to their synergistic enhancement on device efficiency, the quasi-2D PeLEDs modified with DPCl exhibited a champion external quantum efficiency (EQE) of 26.07%. This study provides a new strategy for tailoring perovskite materials through A′-site engineering, offering significant insights into the development of high-performance PeLEDs.}, archive = {J_ANGEW}, author = {Xiangqian Qin and Mingliang Li and Yaping Zhao and Zelong Li and Hongwei Zhang and Jiefeng Luo and Chiayun Liu and Jiasheng Li and Zongtao Li and Zhanhua Wei}, doi = {10.1002/anie.202513755}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513755}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploring coupling-derived a′-site cations for crystallization delay and defect passivation in quasi-2D perovskite light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Single-step insertion of organic sulfur into a Fe6C carbide carbonyl cluster, including the natural amino acid L-cysteine: Vibrational circular dichroism and chirality transfer. ANGEW, 64(38), e202513702. (www)

  @article{ , abstract = {We present a straightforward and versatile synthetic route to Fe 6 C carbide carbonyl clusters containing organosulfur ligands, including the chiral amino acid L - and D -cysteine. Reaction of the reduced cluster [NEt 4 ] 4 [Fe 6 C(CO) 15 ] ( 1 ) with thiols (RSH) or disulfides (RSSR) affords novel functionalized hexa-iron carbide clusters [NEt 4 ] 3 [Fe 6 C(CO) 14 (SR)] (R = CH 3 , 2 ; C 6 H 5 , 3 ; p -C 6 H 4 CH 3 , 4 ; L -cysteine, L - 5 ; D -cysteine, D - 5 ). Compounds 2–5 have been characterized by Fourier transform infrared (FT-IR), 1 H and 13 C{ 1 H} nuclear magnetic resonance (NMR) spectroscopy, and the molecular structures of 2–4 have been determined by single-crystal X-ray diffraction (SC-XRD). The chirality of the L -5 and D -5 enantiomers has been investigated by vibrational circular dichroism (VCD), and this represents the first VCD study of chiral metal carbonyl clusters. Combined analyses of VCD and calculated density functional theory (DFT) spectra clearly point out the occurrence of chirality transfer from the chiral organosulfur ligand to the CO ligands, as indicated by the presence of VCD bands in the ν CO region of both L -5 and D -5 . This unprecedented transfer of chirality among different ligands arises from close interactions between the CH 2 and CH hydrogens of coordinated cysteine and the CO shell of the clusters.}, archive = {J_ANGEW}, author = {Francesca Forti and Andrea Pellegrini and Cristiana Cesari and Cristina Femoni and Maria Carmela Iapalucci and Michele Mancinelli and Stefano Zacchini}, doi = {10.1002/anie.202513702}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-step insertion of organic sulfur into a Fe6C carbide carbonyl cluster, including the natural amino acid L-cysteine: Vibrational circular dichroism and chirality transfer}, volume = {64}, year = {2025}, }
• (2025). Narrowband organic afterglow materials exhibiting 11.2 nm FWHM, 38% phosphorescence efficiency and 1.5 s emission lifetime under ambient conditions. ANGEW, 64(38), e202513685. (www)

  @article{ , abstract = {Narrowband organic room-temperature phosphorescence (RTP) remains rare due to significant high-frequency vibronic coupling in T 1 →S 0 electronic transition, where T 1 and S 0 represent the lowest triplet excited state and ground state, respectively. Here, we report coronene-derived ( CoDe ) luminophores exhibiting ultra-narrowband RTP (full width at half maximum FWHM = 11.2 nm) with a 1.5 s lifetime and 38% afterglow efficiency in a phenyl benzoate (PhB) matrix. The narrow emission arises from enhanced coupling with low-frequency vibrational modes in localized excitation (LE) states, as supported by vibronic simulations. Under high-power excitation, the CoDe -PhB further exhibits organic long-persistent luminescence (OLPL) lasting over 40 min (FWHM = 14.7 nm), governed by a two-photon ionization-induced charge-separation mechanism. The materials are processable via melt-casting and excitable by ambient or white light, offering practical utility for high-color-purity afterglow display and lighting applications. This work establishes low-frequency vibronic engineering as a new route to narrowband RTP and OLPL emitters beyond conventional multi-resonance-based designs.}, archive = {J_ANGEW}, author = {Jialiang Jiang and Tengyue Wang and Zhe Mo and Yue Zhang and Yuanyuan Chen and Yuming Su and Kaka Zhang}, doi = {10.1002/anie.202513685}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513685}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Narrowband organic afterglow materials exhibiting 11.2 nm FWHM, 38% phosphorescence efficiency and 1.5 s emission lifetime under ambient conditions}, volume = {64}, year = {2025}, }
• (2025). Tailoring lattice oxygen redox and robust structure stability in high-entropy superlattice layered cathode for superior potassium-ion storage. ANGEW, 64(38), e202513581. (www)

  @article{ , abstract = {To address the inherent limitations of layered cathodes in terms of stability, kinetics, and energy density, a high-entropy superlattice layered oxide (K 0.7 Mn 0.4 Li 0.1 Co 0.125 Ni 0.125 Fe 0.125 Cu 0.125 O 2 , KMNCFCL 0.1 ) is proposed as a cathode for K-ion storage. High-entropy composition and [Li─O─K] configuration coupled with Cu─O covalency and local CuO 6 distortion trigger and stabilize lattice oxygen redox through the anionic–cationic redox inversion, essentially a premature ligand-to-metal charge transfer (LMCT), thereby alleviating potential issues of severe voltage hysteresis and capacity fade by restraining oxygen release and cation migration. Superior phase stability and strain tolerance with a solid-solution mechanism benefited from high-entropy stabilization, and “cocktail” effects can be successfully achieved by eliminating serious structural evolutions induced by Jahn–Teller (J–T) lattice distortion, O─O repulsion, and intercalation of electrolyte molecules. Furthermore, the enlarged interlayer spacing and disrupted K + /vacancy ordering facilitate rapid K-ion migration with a low diffusion barrier. Therefore, KMNCFCL 0.1 delivers a high energy density of 327.8 Wh kg −1 , superior cyclic stability with a long lifespan of over 300 cycles, and excellent rate capability. This research opens up new possibilities for achieving groundbreaking cathodic functionality in potassium layered oxides.}, archive = {J_ANGEW}, author = {Meng Ma and Kai Yao and Xiaoying Zhai and Yixin Zhu and Xiubo Yang and Dina Fattakhova-Rohlfing and Hua Kun Liu and Shi Xue Dou and Shaokun Chong and Wei Huang}, doi = {10.1002/anie.202513581}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513581}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring lattice oxygen redox and robust structure stability in high-entropy superlattice layered cathode for superior potassium-ion storage}, volume = {64}, year = {2025}, }
• (2025). Design of aminophosphine precursor for robust synthesis of InP quantum dots with near-unity quantum yield. ANGEW, 64(38), e202513545. (www)

  @article{ , abstract = {Aminophosphines have emerged as promising phosphorus candidates for the synthesis of InP quantum dots (QDs), offering an alternative to traditional tris(trimethylsilyl) phosphine. However, the relatively low reactivity of conventional aminophosphines has led to broader size distribution, resulting in higher full-width at half-maximum (FHWM) with lower photoluminescence quantum yield (PLQY). Here, we introduce a new aminosphosphine, bis(bis(trimethylsilyl)amino) phosphine (P[N(SiMe 3 ) 2 ] 2 H), to address this issue. Using nuclear magnetic resonance (NMR) spectroscopy, we demonstrate the direct nucleophilic activation of the P[N(SiMe 3 ) 2 ] 2 H with InCl 3 , leading to the rapid nucleation of InP QDs at a relatively lower synthesis temperature. This enabled to achieve InP/ZnSeS/ZnS QDs with near-unity PLQY and a FWHM of 48 nm. These findings suggest a new chemistry for the synthesis of InP QDs, and could be extended to other III-V QDs for advanced optoelectronic applications.}, archive = {J_ANGEW}, author = {Doheon Yoo and Euk Hyun Kim and Ji-Seoung Jeong and Ji Yeon Ryu and Sang Man Koo and Min-Jae Choi}, doi = {10.1002/anie.202513545}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513545}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of aminophosphine precursor for robust synthesis of InP quantum dots with near-unity quantum yield}, volume = {64}, year = {2025}, }
• (2025). Achieving efficient self-driven full-stokes photodetection in optically active ferroelectric. ANGEW, 64(38), e202513386. (www)

  @article{ , abstract = {Full-Stokes polarization detection, enabling the acquisition of complete polarization information, is crucial across various fields such as target identification, robotic perception, and 3D reconstruction. Nevertheless, achieving efficient multiple polarization state detection simultaneously with high recognition accuracy in a compact device remains a significant challenge. Herein, for the first time, we report an optically active ferroelectric OA 2 EA 2 Pb 3 Br 10 ( 1 , where OA is n-octylammonium, EA is ethylammonium), capable of realizing a self-driven full-Stokes polarization detection. Utilizing the bulk photovoltaic effect in 1 , simultaneous detection of both linearly and circularly polarized light can be achieved without requiring an external bias. The in-plane photodetection configuration exhibits a high linear polarization ratio of 2.7 and a circular polarization anisotropy factor of 0.46. More importantly, the full-Stokes polarization detection achieves low average measurement errors for the Stokes parameters of 3.2%–5.3%. This study establishes a new paradigm for the rational design of ferroelectric materials that enable self-driven, filterless full-Stokes polarization detection.}, archive = {J_ANGEW}, author = {Zhijin Xu and Tianqi Chen and Jing Liang and Xin Dong and Yaru Geng and Lina Li and Zhihua Sun and Junhua Luo}, doi = {10.1002/anie.202513386}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513386}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving efficient self-driven full-stokes photodetection in optically active ferroelectric}, volume = {64}, year = {2025}, }
• (2025). Controlling the mechanical response of polymers via metal induced coordination conformational changes. ANGEW, 64(38), e202513376. (www)

  @article{ , abstract = {The modulation of mechanical properties in polymers with metal binding ligands has largely been achieved via crosslinking between polymer chains induced by metal ion binding to pendant or end ligating groups. In this work, incorporation of ethylenediaminetetraacetic acid (H 4 edta) into the main chain backbone of flexible, linear polymers results in substantial modulation of mechanical properties via conformational changes in the imbedded ligand within the polymer backbone induced by metal ion binding. Upon the addition of metal ions, these polymers transform from viscous liquids into solids with improved elastic characteristics. Polymer strength and toughness are significantly enhanced without the need for extensive polymer crosslinking. This approach represents a new paradigm in using metal ions to modulate the mechanical properties of organic polymers.}, archive = {J_ANGEW}, author = {Mingshi Zhang and Seth Cohen}, doi = {10.1002/anie.202513376}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513376}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlling the mechanical response of polymers via metal induced coordination conformational changes}, volume = {64}, year = {2025}, }
• (2025). Designing molecular reactor of interlayer dual-atom toward urea electrosynthesis. ANGEW, 64(38), e202513341. (www)

  @article{ , abstract = {Electrocatalytic C─N coupling offers a sustainable alternative to energy-intensive industrial processes for urea synthesis. Herein, we design conjugated polymer-based molecular reactors featuring interlayer diatomic Cu–N 4 sites and precisely tunable spacings (4.0, 4.6, and 5.7 Å) to optimize CO 2 and nitrate coupling. The 4.0 Å-spaced copper polyphthalocyanine (CuPPc-4.0) delivers a remarkable urea yield rate of 460.0 mmol h −1 g −1 with 26.1% Faradaic efficiency at −1.3 V (versus RHE), outperforming wider-spaced analogs. The optimal 4.0 Å cavity spatially confines reactants and intermediates, matching urea's molecular dimensions (3.5 Å), thereby enhancing C–N coupling and urea synthesis activity, while the layered AA stacking structure stabilizes unbonded diatomic Cu configurations, preventing aggregation and ensuring durability. Mechanistic studies reveal that while ball-milling treatment increases single-atom exposure, it disrupts the layered architecture and eliminates interlayer diatomic sites, reducing activity by about 50%. This work demonstrates a multidimensional catalyst design integrating atomic precision and molecular confinement for sustainable electrosynthesis.}, archive = {J_ANGEW}, author = {Kefan Zhang and Yuyan Liu and Xupeng Qin and Peilian Hou and Chu Zhang and Dafeng Yan and Chade Lv and Dawei Chen and Yong Feng and Ze Wu and Yujie Wang and Shuxuan Liu and Yingjie Li and Yongpan Hu and Kun Feng and Jun Zhong and Qinghua Liu and Chen Chen and Shuangyin Wang}, doi = {10.1002/anie.202513341}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513341}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Designing molecular reactor of interlayer dual-atom toward urea electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). A natural oxygen-harvesting electrode enables aeration-free electrochemical advanced oxidation for in situ water remediation. ANGEW, 64(38), e202513329. (www)

  @article{ , abstract = {Electro-Fenton treatment through the two-electron oxygen reduction reaction (2e − ORR) offers an effective approach for degrading persistent organic pollutants (POPs) in water; however, aeration is always required to overcome the low solubility of oxygen in water, ensuring adequate oxygen availability for the 2e − ORR to generate H 2 O 2 and facilitate its transport for activation into hydroxyl radicals. The aeration energy consumption can reach tens of times higher than the energy required for the electrochemical reactions themselves. To address this, we developed an aeration-free dual-cathode system featuring a natural oxygen-harvesting electrode (NOHE). The NOHE's superhydrophobic and microporous structure effectively captures and utilizes anode-generated oxygen for H 2 O 2 synthesis (957.1 mg g cat −1 ) without external aeration. By decoupling H 2 O 2 generation and activation into separate cathodes, the system optimizes both processes independently, achieving superior efficiency. This design demonstrated rapid removal of bisphenol AF (BPAF) in saline environments, achieving 98% mineralization and exhibiting excellent operational stability over 90 h continuous use. By eliminating energy-intensive aeration, our approach may open the avenue for a scalable, sustainable solution for in situ water remediation, with broad applicability in diverse aquatic environments.}, archive = {J_ANGEW}, author = {Sijin Zuo and Geyi Zheng and Dailin Yang and Juan Wang}, doi = {10.1002/anie.202513329}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513329}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A natural oxygen-harvesting electrode enables aeration-free electrochemical advanced oxidation for in situ water remediation}, volume = {64}, year = {2025}, }
• (2025). Flexible hydrogen-bonded organic framework with anthracene core for recognition of benzene over cyclohexane. ANGEW, 64(38), e202513288. (www)

  @article{ , abstract = {Flexibility is considered one of the most critical features of framework materials, playing a vital role in applications such as adsorption and separation. Hydrogen-bonded organic frameworks (HOFs) exhibit unique flexibility derived from their weak, reversible hydrogen-bonding interactions; however, realizing controlled and functional flexible behavior in HOFs remains a synthetic challenge. Herein, we report a flexible hydrogen-bonded organic framework, HOF-FJU-119 , constructed from an anthracene-core, that exhibits multimode guest-responsive behavior. Upon activation, HOF-FJU-119a undergoes distinct gate-opening transformations in response to CO 2 at 196 K and benzene vapor at room temperature. Single-crystal X-ray diffraction (SCXRD) and vapor adsorption isotherms reveal the emergence of new adsorption sites in the benzene-loaded phase, driven by strong interactions and the flexibility of C≡N⋯H─C hydrogen bonds, enabling selective benzene/cyclohexane separation. Notably, the adsorption of benzene induces a visible color change in fluorescence emission and a red shift of approximately 60 nm. Structural and density functional theory (DFT) analyses confirm increased molecular planarity, extended conjugation, and a narrowed bandgap. This work demonstrates a rare integration of selective adsorption, molecular recognition, and signal transduction within a single crystalline framework, offering a versatile platform for the development of intelligent porous materials with real-time visual tracking capabilities.}, archive = {J_ANGEW}, author = {Furong Yuan and Guanrui Han and Yunbin Li and Wuji Wei and Lei He and Yanting Chen and Chenxin Chen and Gaoyan Lan and Shengchang Xiang and Banglin Chen and Zhangjing Zhang}, doi = {10.1002/anie.202513288}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513288}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flexible hydrogen-bonded organic framework with anthracene core for recognition of benzene over cyclohexane}, volume = {64}, year = {2025}, }
• (2025). Strictly periodic, adenine-directed one-pot assembly of multicomponent Metal–Organic framework: Structural insights and ethylene purification. ANGEW, 64(38), e202513208. (www)

  @article{ , abstract = {The pursuit of advanced adsorbents with exceptional gas adsorption and separation capability represents a highly promising yet challenging research frontier. Several quinary multicomponent metal-organic frameworks (MOFs) have been documented in the literature, however, the construction of quinary MOFs through the synergistic integration of two distinct organic ligands and three different metal clusters remains scarce. Herein, solvothermal reaction of Zn(OAc) 2 ·2H 2 O with adenine and 1,2,4-benzenetricarboxylic anhydride afforded a novel MOF of Quin-Zn-Ad-BTC. SCXRD reveals that Quin-Zn-Ad-BTC incorporates three distinct zinc-based structural units of a mononuclear [ZnN 2 (O 2 C─) 2 ], a dinuclear [Zn 2 (Ad) 3 (O 2 C─) 2 ], and a hexanuclear [Zn 6 N 3 ( μ -H 2 O) 3 (Ad) 3 (O 2 C─) 6 ], respectively. These units assemble into a novel quinary MOF structure, distinguished as the unusual material constructed from dual ligands and triple clusters. It features three interconnected cage-like cavities replete with uncoordinated carboxylate oxygen atoms and Watson─Crick sites. Gas adsorption investigations indicate that Quin-Zn-Ad-BTC demonstrates notable selectivity toward acetylene, ethane, and propylene adsorption, enabling the single-step ethylene purification from trinary C 2 mixtures and binary MTO products. Computational simulations reveal that preferential adsorptions are facilitated by different supramolecular interaction strengths. Given its cost-effective and readily accessible synthesis precursors, along with excellent thermal and chemical stability, Quin-Zn-Ad-BTC holds great promise for advanced gas adsorption and separation applications.}, archive = {J_ANGEW}, author = {Ya-Nan Ma and Teng-Long Liu and Wei-Hong Zhang and Cheng-Hang He and Dong-Xu Xue}, doi = {10.1002/anie.202513208}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513208}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strictly periodic, adenine-directed one-pot assembly of multicomponent Metal–Organic framework: Structural insights and ethylene purification}, volume = {64}, year = {2025}, }
• (2025). Engineering intermolecular packing mode of oxygen-bridged cyclized boron-based MR-TADF emitters enables high-efficiency deep-blue narrowband OLEDs. ANGEW, 64(38), e202513129. (www)

  @article{ , abstract = {The development of high-efficiency and low-cost multi resonance thermally activated delayed fluorescence (MR-TADF) emitters especially in the deep-blue region is critically limited due to intrinsic excimer quenching of planar π-extended frameworks. Herein, a novel design strategy is reported for realizing high-efficiency oxygen-bridged cyclized boron-based MR-TADF emitters via engineering intermolecular packing mode. Three organic donor–acceptor (D–A) molecules with different molecular configurations are designed and synthesized, which can readily form modulated packing patterns with fastidiously regulating intermolecular charge transfer (CT) in crystalline states. Experimental and theoretical investigations expose that the intermolecular D–A packing modes could be formed in relatively planar molecular architecture, which cannot only fix the intermolecular CT excited-state configuration, but the multiple conversion channels of triplet excitons can also be involved synergistically to accelerate the spin-flip, and thus achieving near-unity PLQY and excellent reverse intersystem crossing rate of 6.7 × 10 5 s −1 in solid states. The optimized OLEDs devices achieve an attractive EQE value of 31.75%, which is at a record high for MR-TADF OLEDs with deep-blue emission. Our strategy boosts the luminescence efficiency of MR-TADF emitters through enabling the participation of multiple triplet states and the confined excited-state conformations induced by intermolecular CT interaction in aggregation state.}, archive = {J_ANGEW}, author = {Yuchao Liu and Shengyu Li and Jinyang Zhao and Wei Ping and Zhi Yang and Lei Hua and Junjie Wang and Shian Ying and Zhongjie Ren and Shouke Yan}, doi = {10.1002/anie.202513129}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513129}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering intermolecular packing mode of oxygen-bridged cyclized boron-based MR-TADF emitters enables high-efficiency deep-blue narrowband OLEDs}, volume = {64}, year = {2025}, }
• (2025). Crown Ether–Peptide rotaxanes. ANGEW, 64(38), e202513115. (www)

  @article{ , abstract = {We report on the metal-free active template synthesis of crown ether–peptide rotaxanes. A 24-crown-8 ring is sufficiently small that the side chains of canonical branched amino acids act as barriers that trap the macrocycle on the particular glycine residue used to assemble the rotaxane. The resulting crown ether–tripeptide rotaxane can subsequently be extended from either or both N- and C-termini of the axle. Three distinct positional isomers of a heptapeptide [2]rotaxane containing three glycine units were selectively synthesized, and in each case the unique position of the crown ether on the peptide axle was confirmed by 1 H nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The three positional isomers adopt different conformations in the region adjacent to the trapped macrocycle, and have different chemical stabilities and secondary interactions in comparison to the unthreaded peptide axle. The crown ether does not inhibit enzymatic proteolysis over the entire length of the heptapeptide–axle rotaxanes, but rather provides significant protection from degradation for the three to four residues local to the encapsulated region. The strategy opens a pathway to new analogs of naturally occurring mechanically interlocked peptides.}, archive = {J_ANGEW}, author = {Peng-Lai Wang and Peng Chen and Raorao Yang and Daniel J. Tetlow and Zhi-Hui Zhang and Jing Han and Stephen D. P. Fielden and Prodip Howlader and Liang Zhang and David A. Leigh}, doi = {10.1002/anie.202513115}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513115}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crown Ether–Peptide rotaxanes}, volume = {64}, year = {2025}, }
• (2025). Long range coherent energy transfer in artificial multichromophoric antenna Systems—A case of breaking kasha's rule. ANGEW, 64(38), e202513001. (www)

  @article{ , abstract = {Ultrafast long-range energy transfer with unitary quantum-yield has been studied in a novel family of artificial DNA-guided multichromophoric antenna complexes with phenanthrene moieties as light harvesters. By means of femtosecond transient absorption spectroscopy and time-dependent density function theory calculations, we demonstrate that the highly efficient long-range energy transfer occurs via a coherent mechanism. It is enabled by photoexcitation of higher lying delocalized excited states of phenanthrene, and hence, can be labelled anti-Kasha in nature. Moreover, we show the important contribution of exciplex formation between acceptor and closest donor.}, archive = {J_ANGEW}, author = {Maryam Nazari Haghighi Pashaki and Caroline D. Bösch and Florian Garo and Ambre Blanc and Marco Marazzi and Ariana Rondi and Michela Gazzetto and Maryam Akbarimoosavi and jean-christophe Tremblay and Simon Matthias Langenegger and Antonio Monari and Robert Häner and Thomas Feurer and Andrea Cannizzo}, doi = {10.1002/anie.202513001}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202513001}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Long range coherent energy transfer in artificial multichromophoric antenna Systems—A case of breaking kasha's rule}, volume = {64}, year = {2025}, }
• (2025). Carbene insertion and furyl migration cascade toward benzofurans. ANGEW, 64(38), e202512949. (www)

  @article{ , abstract = {Divergent access to complex molecular skeletons from the same set of readily available raw materials has been a primary goal of chemical synthesis, owing to their widespread application in drug research. In this study, a copper-catalyzed insertion reaction of a disubstituted carbene into an unsaturated imine has been developed to form β,γ-unsaturated carbonyl compounds with an α-quaternary carbon center, which subsequently undergo an unprecedented forward 1,2-/backward 1,4-furyl migration cascade, ultimately affording a highly substituted benzofuran. A formal 1,3-furan migration is involved in this multistep cascade sequence, broadening the substrate scope under mild reaction conditions.}, archive = {J_ANGEW}, author = {Tu Zeng and Shiqing Huang and Yingjian Gong and Li Li and Keyi Guo and Shitian Wu and Huiyang Zhan and Shiyu Xu and Xingcan Zhang and Baosheng Li}, doi = {10.1002/anie.202512949}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbene insertion and furyl migration cascade toward benzofurans}, volume = {64}, year = {2025}, }
• (2025). Intramolecular lithiation-borylation for the stereoselective synthesis of cyclopentyl and cyclobutyl bis-boronic esters. ANGEW, 64(38), e202512896. (www)

  @article{ , abstract = {Saturated carbocycles are common motifs in natural products and pharmaceuticals, and so methods for their construction, particularly with high diastereo- and enantiocontrol, are of high importance. Lithiation-borylation has emerged as powerful methodology for the stereocontrolled construction of acyclic carbon chains but has not previously been used for the stereocontrolled synthesis of carbocycles. Herein, we report that benzylic diethylcarbamates with a tethered vicinal bis-boronic ester moiety can be deprotonated with lithium amide bases, resulting in cyclization and 1,2-metallate rearrangement to give carbocycles. This intramolecular lithiation-borylation reaction is completely regioselective and, rather than being stereospecific like the acyclic variants, it is diastereoconvergent. Stereochemistry of the boronic ester is retained but the benzylic stereocenter undergoes epimerization, furnishing carbocycles with high diastereo- and enantiocontrol from easily accessible precursors. Site-selective transformations of the bis-boronic ester products are also demonstrated.}, archive = {J_ANGEW}, author = {Christopher J. Cope and Margherita Zanini and Malcolm R. P. George and Daniel Otero and Jana Sendra and Adam Noble and Julien Lefranc and Raphaël Robiette and Varinder K. Aggarwal}, doi = {10.1002/anie.202512896}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512896}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intramolecular lithiation-borylation for the stereoselective synthesis of cyclopentyl and cyclobutyl bis-boronic esters}, volume = {64}, year = {2025}, }
• (2025). Reductive deamination of a diaminogermylene promoted by an aluminyl anion: Isolation of Ge(I), ge(0) and ge(-i) products. ANGEW, 64(38), e202512812. (www)

  @article{ , abstract = {The reaction of the potassium aluminyl K[Al(NON)] ([NON] 2− = [O(SiMe 2 NDipp) 2 ] 2− , Dipp = 2,6- i Pr 2 C 6 H 3 ) with the diaminogermylene Ge[N(SiMe 3 ) 2 ] 2 afforded [K(C 6 H 6 )][Al(NON){(Me 3 Si) 2 NGeGeN(SiMe 3 ) 2 }] containing an AlGe 2 ring. Structural and computational analysis confirm an aluminacyclodigermene complex that can be considered as an η 2 -coordinated digermyne at aluminium with Ge(I) centres. This compound is an intermediate on the reduction pathway to K 3 [(Ge 4 ){Al(NON)} 2 {N(SiMe 3 ) 2 }], which contains a distorted tetrahedral cluster of Ge(-I) centres. Characterisation of the dialumane (NON)Al─Al(NON) from this reaction is indicative of sequential one electron redox processes initiated by the aluminyl anion. Repeating the reaction in methylcyclohexane afforded K 2 [{Al(NON)} 2 (Ge 2 )], containing a formally digermanium(0) unit with an exceptionally long Ge═Ge double bond.}, archive = {J_ANGEW}, author = {George W. A. Smith and Andrea O'Reilly and Claire L. McMullin and J. Robin Fulton and Martyn P. Coles}, doi = {10.1002/anie.202512812}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512812}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reductive deamination of a diaminogermylene promoted by an aluminyl anion: Isolation of Ge(I), ge(0) and ge(-i) products}, volume = {64}, year = {2025}, }
• (2025). The role of hydrogen bonding in the formation and dynamics of two distinct types of cyclic supramolecular polymers. ANGEW, 64(38), e202512811. (www)

  @article{ , abstract = {Cyclic polymers are attractive synthetic targets in both polymer chemistry and supramolecular polymer (SP) chemistry; however, there is a gap between these two research fields in terms of the synthetic strategies involved, and achieving a commonality remains elusive. Herein, we describe the formation of two distinct types of cyclic SPs from structurally similar rosette-shaped molecules. The first SP (Type I) is characterized by a uniform diameter and circularity, whereas the other (Type II) has properties reminiscent of flexible cyclic covalent polymers. Remarkably, the only difference in the structures of the two monomers that form these completely distinct cyclic SPs is the absence (Type I) or presence (Type II) of hydrogen-bonding moieties. An all-atom molecular-dynamics simulation suggested that the Type II SP can adopt various “conformations” due to the dynamic nature of its hydrogen bonds, thereby behaving like a flexible covalent polymer. Real-time high-speed atomic-force microscopy (AFM) confirmed the presence of flexibility in the chains of the Type II SP on the observation timescale (several tens of seconds). Our results therefore highlight an example of a similarity between a covalent polymer and a noncovalent SP that should help to bridge the gap between these polymers, leading to new advanced materials.}, archive = {J_ANGEW}, author = {Yuki Nodera and Yuichiro Watanabe and Yoshiki Ishii and Go Watanabe and Christian Ganser and Takayuki Uchihashi and Kazunori Sugiyasu}, doi = {10.1002/anie.202512811}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The role of hydrogen bonding in the formation and dynamics of two distinct types of cyclic supramolecular polymers}, volume = {64}, year = {2025}, }
• (2025). Organic spin-state photoswitches. ANGEW, 64(38), e202512691. (www)

  @article{ , abstract = {Organic spin-state photoswitches represent an emerging class of molecular systems capable of reversibly modulating electronic spin states using light. This review provides a comprehensive overview of the fundamental mechanisms underlying two principal switching modes: photoconformational and photochemical. Emphasis is placed on their structural design, magnetic behavior, and the methods used for their characterization, including electron paramagnetic resonance (EPR) and UV–vis spectroscopy. Selected examples illustrate the ability of these systems to control spin-polarized states, alter magnetic exchange interactions, or switch between singlet and triplet spin states upon photoirradiation. The review also discusses challenges related to thermal stability, bistability, and operation under ambient conditions. Emerging strategies for integrating photoswitches with persistent radicals or redox-active units are highlighted for their potential in molecular electronics and quantum information science. Notably, light-induced diradical species in such systems are gaining recognition as molecular qubits, offering long coherence times and spectroscopic addressability essential for quantum gate operations. By exploring design principles and technological implications, this review underscores the unique position of all-organic spin-state photoswitches at the intersection of photochemistry, magnetism, and quantum materials development.}, archive = {J_ANGEW}, author = {Takuma Miyamura and Joël Schlecht and Oliver Dumele}, doi = {10.1002/anie.202512691}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512691}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic spin-state photoswitches}, volume = {64}, year = {2025}, }
• (2025). Spillover-mediated h* redistribution promotes electrocatalytic acetonitrile hydrogenation in PEM reactors. ANGEW, 64(38), e202512654. (www)

  @article{ , abstract = {Electrocatalytic acetonitrile hydrogenation (EAH) provides a sustainable route for ethylamine synthesis, yet suffers from low productivity, competitive hydrogen evolution reaction (HER), and high energy consumption due to suboptimal catalyst and reactor design. To overcome these challenges, we describe a palladium-copper hybrid catalyst that employs spillover-mediated active hydrogen (H*) redistribution mechanism. Hydrogen spillover from palladium with high H* coverage to copper with low H* coverage creates H* redistribution: reduced H* coverage of Pd mitigates HER while maintaining efficient EAH, and increased H* availability of Cu promotes EAH without activating stagnant HER. Integration of these catalysts into both cathode and anode of a proton exchange membrane electrolyzer enabled efficient ethylamine electrosynthesis and formic acid electrooxidation over 100 h, achieving exceptional ethylamine productivity (6160.0 ± 119.1 mmol g cat −1 h −1 ) and Faradaic efficiency (94.2 ± 1.6%) at record-low energy consumption (3.55 kWh kg ethylamine −1 ). This work marks a critical advancement toward sustainable ethylamine electrosynthesis.}, archive = {J_ANGEW}, author = {Shan Huang and Bingying Han and Ye Liu and Zijie Cheng and Huibin Ge and Lianbing Zhang and Riguang Zhang and Baojun Wang and Jie Kong and Jiayuan Li}, doi = {10.1002/anie.202512654}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spillover-mediated h* redistribution promotes electrocatalytic acetonitrile hydrogenation in PEM reactors}, volume = {64}, year = {2025}, }
• (2025). Smiles-truce cascades enable heteroaryl cyclopropane and sultine synthesis. ANGEW, 64(38), e202512577. (www)

  @article{ , abstract = {We describe a triple C─C bond cascade process for heteroaryl cyclopropane synthesis, through the reaction of vinyl sulfonium salts and sulfones under mild conditions. An initial conjugate addition (C─C bond 1) sets up a Smiles–Truce rearrangement (C─C bond 2), with a final 3-exo- tet ring closure (C─C bond 3) affording cyclopropanes. Serendipitously, we uncovered a novel reaction variant that affords sultines, an under-explored heterocycle with potential application as a bioisostere in medicinal chemistry.}, archive = {J_ANGEW}, author = {Thomas Sephton and Zi Liu and Michael F. Greaney}, doi = {10.1002/anie.202512577}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512577}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Smiles-truce cascades enable heteroaryl cyclopropane and sultine synthesis}, volume = {64}, year = {2025}, }
• (2025). Chemoenzymatic skeletal editing of natural product scaffolds via p450-controlled site-selective ring expansion at aliphatic C─H sites. ANGEW, 64(38), e202512576. (www)

  @article{ , abstract = {Methods for introducing subtle modifications at the level of single atoms/bonds (“skeletal editing”) are highly desirable in organic and medicinal chemistry, owing to their potential for fine-tuning the structure and biological activity of organic molecules. Here, we report a chemoenzymatic strategy for enabling the skeletal editing of organic frameworks via ring expansion at the level of one or more aliphatic (methylene) C─H sites, as achieved through the synergistic combination of P450-mediated site-selective oxidation with subsequent Baeyer–Villiger rearrangement or ketone homologation. Combining this approach with engineered P450 catalysts exhibiting divergent regioselectivity enabled the expeditious synthesis of a panel of ring-expanded analogs of various complex natural product substrates. Importantly, the skeletal modification was found to drastically altered the anticancer activity of some of these compounds. By the direct targeting of aliphatic C─H sites with tunable site-selectivity, this strategy provides a powerful tool to rapidly access skeletally edited derivatives of natural products and other bioactive molecules for applications in drug discovery and chemical biology.}, archive = {J_ANGEW}, author = {John M. Bennett and Andrew R. Bortz and Zheyuan Wang and Muhammed Fastheem and Rudi Fasan}, doi = {10.1002/anie.202512576}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512576}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemoenzymatic skeletal editing of natural product scaffolds via p450-controlled site-selective ring expansion at aliphatic C─H sites}, volume = {64}, year = {2025}, }
• (2025). Anion-regulated Deposition–Dissolution chemistry in acidic aqueous Indium─MnO2 batteries. ANGEW, 64(38), e202512463. (www)

  @article{ , abstract = {Acidic aqueous metal─MnO 2 rechargeable batteries enable high-capacity energy storage via a two-electron MnO 2 /Mn 2+ redox chemistry but suffer from severe anode corrosion and poor reversibility in acidic environments. Here, we report an acidic In─MnO 2 battery (IMB) system that employs anion-regulated interfacial chemistry to enable reversible deposition–dissolution reactions at both electrodes. The In 3+ /In redox couple offers a favorable potential that mitigates acidic corrosion while matching the MnO 2 two-electron redox. Systematic investigation of anion effects reveals that concentrated Cl − anions restructure the In 3+ solvation, forming stable chloro-complexes that lower dissociation energy and promote uniform Indium (In) deposition. Conversely, SO 4 2− -rich electrolytes impede In plating but enhance MnO 2 crystallization and MnO 2 /Mn 2+ reversibility. Through tailored Cl − /SO 4 2− ratios and an anion-decoupled dual-electrolyte configuration, the battery operates at ∼1.7 V with 72.3% energy efficiency (EE) and over 1500 cycles at 5 mA cm −2 . Furthermore, we demonstrate an electrode-less IMB using a Bi substrate at the anode, where in situ alloying-driven In deposition enables over 2000 stable cycles at 4 mA cm −2 (2 mAh cm −2 ), delivering a compelling energy density of 484.5 Wh kg −1 and a high cumulative areal capacity of 4120 mAh cm −2 . This work establishes a design paradigm coupling anion-regulated interfacial chemistry with substrate engineering for high-performance acidic IMB.}, archive = {J_ANGEW}, author = {Yuwei Sun and Chen Wang and Ling Gao and Tan Wang and Yunhui Huang and Jing Fu}, doi = {10.1002/anie.202512463}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512463}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion-regulated Deposition–Dissolution chemistry in acidic aqueous Indium─MnO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Cyclochlorotine hydroxylase CctR reveals DUF3328 as a family of copper-dependent metalloenzymes. ANGEW, 64(38), e202512449. (www)

  @article{ , abstract = {DUF3328 is a protein family widely found in fungal natural product biosynthesis pathways. Although DUF3328 proteins have long been implicated in diverse modifications of inert C( sp 3 )─H bonds, including halogenation, hydroxylation, and macrocyclization, the biochemical properties and catalytic mechanisms of DUF3328 proteins remain elusive. Here, we report the characterization of the DUF3328 protein CctR, which catalyzes C( sp 3 )─H hydroxylation of fungal cyclic peptide cyclochlorotine. Through AlphaFold modeling, in vitro biochemical characterization, and spectroscopic analysis, we demonstrate that CctR is a membrane-associated copper-dependent enzyme that functions as a homodimer. The dimerization of CctR is mediated by its transmembrane helix, a four-helix coiled coil, and C-terminal disulfide bonds. The conserved HxxHC(x) n HxxHC motif, characteristic of the DUF3328 superfamily, is anchored on the dimerization interface and forms a binuclear copper coordination center. Moreover, we show that CctR is dioxygen-dependent and requires electron input for the hydroxylation reaction. Together, these findings define DUF3328 as a previously unrecognized family of binuclear copper-dependent metalloenzymes, capable of catalyzing diverse chemical transformations, and lay the groundwork for future discovery of novel biocatalysts within this widespread enzyme class.}, archive = {J_ANGEW}, author = {Wentao Huang and Jakob K. Reinhardt and Anru Tian and Xiao Zhang and Binghui Li and Noah Gould and Sashirekha Nallapati and Alexander R. Ivanov and Yi Wang and Jason J. Guo and David E. Budil and Jing-Ke Weng}, doi = {10.1002/anie.202512449}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512449}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyclochlorotine hydroxylase CctR reveals DUF3328 as a family of copper-dependent metalloenzymes}, volume = {64}, year = {2025}, }
• (2025). Divergent synthesis and crystal engineering of room-temperature phosphorescent carbonyl-bridged triphenylamines. ANGEW, 64(38), e202512446. (www)

  @article{ , abstract = {Organic materials with room temperature phosphorescence (RTP) are a growing research topic, with recent investigations revealing a strong effect of the crystal packing on the RTP properties. However, these relationships are difficult to decipher, as the crystal packing affects both the intermolecular interactions and the molecular conformation. Here, we report a divergent synthetic strategy to generate a family of rigid carbonyl-bridged triphenylamine (TPA)-based chromophores via metal-free transformations of the same starting material, and exploit this family to investigate the effects of crystal packing on the solid state RTP properties. The minor bridge modifications lead the TPA derivatives to adopt three distinct crystal packing motifs: parallel columnar stacks, antiparallel zigzags, and nonparallel dimerized arrangements. Despite the nearly identical RTP spectra across the series, the proportion of phosphorescence in their emission and the RTP lifetimes are shown to differ as a result of the different crystal motifs. Computational investigations of dimer models of the solid state reveal that the interplay between fluorescence and triplet formation can be modelled by identifying the aggregate character of dimers in the crystal, but only if pairs in multiple dimensions of the crystal are considered.}, archive = {J_ANGEW}, author = {Cory Ruchlin and Durbis J. Castillo-Pazos and Juan D. Lasso and Ehsan Hamzehpoor and Aleksandar Mikov and Chao-Jun Li and Dmytro F. Perepichka}, doi = {10.1002/anie.202512446}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512446}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent synthesis and crystal engineering of room-temperature phosphorescent carbonyl-bridged triphenylamines}, volume = {64}, year = {2025}, }
• (2025). Photosensitization-controlled dynamic organic room-temperature phosphorescence. ANGEW, 64(38), e202512424. (www)

  @article{ , abstract = {Dynamic organic room temperature phosphorescence (RTP) materials have enabled potential applications in intelligent optoelectronics owing to their reversibly dynamic luminescence features. However, in most reported dynamic RTP materials, chromophores serve dual roles as phosphorescent emitters and oxygen sensitizers. This leads to uncontrollable dynamic processes and a reduction in phosphorescence performance. Herein, we present a strategy for achieving controllable dynamic RTP and maintaining the phosphorescent performance by integrating triplet photosensitizers into the RTP polymer. Specifically, by adjusting the concentration of the photosensitizer, the photoactivation time of the copolymers can be accurately controlled within the range of 3–30 s. Notably, after photoactivation, the phosphorescence lifetime of the polymer was prolonged from 558 to 1017 ms, which is longer than that of the polymer lacking a photosensitizer. The versatility of the design strategy was further validated by synthesizing a diverse range of RTP polymers through copolymerization and physical doping, as well as by employing alternative photosensitizers. Given the dynamic RTP feature, we demonstrated potential applications in dynamic intelligent afterglow displays and multilevel information encryption. This work advances the development of controllable dynamic RTP polymers and expands the application scope of stimuli-responsive materials in intelligent optoelectronics.}, archive = {J_ANGEW}, author = {Jingyi Shan and Huan Chen and Yaru Gao and Mengyang Dong and Anqi Lv and Huili Ma and Yanli Zhao and Wei Huang and Long Gu}, doi = {10.1002/anie.202512424}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photosensitization-controlled dynamic organic room-temperature phosphorescence}, volume = {64}, year = {2025}, }
• (2025). Rhenium-doping to promote structural evolution of metallic iridium to oxides on platinum nanowire bundles for acidic oxygen evolution. ANGEW, 64(38), e202512317. (www)

  @article{ , abstract = {The current high Ir loading (∼2 mg Ir cm −2 ) in proton exchange membrane water electrolyzers (PEMWEs) severely hinders their applications for green hydrogen production. Reducing Ir loading while maintaining high performance and durability for the oxygen evolution reaction (OER) anode is critical for the Gigawatt-scale deployment of PEMWEs. Herein, we report an ultra-low Ir anode, consisting of Re-doped Ir nanoparticles anchored on Pt nanowire networks, enabling rational catalyst design at the atomic scale and electrode structure engineering at the nanoscale. The unique doping of Re into Ir was explored as an effective strategy to promote the desirable conversion from metallic Ir to amorphous IrO x during the acidic OER, thus benefiting intrinsic activity and stability enhancements. Notably, the Pt nanowire bundles serve as a support to enhance electrical conductivity and provide a high-surface-area, robust, and interconnected electrode structure, significantly increasing Ir utilization and electron/mass transport at the device level. Three-electrode electrochemical tests revealed that the developed Ir catalyst exhibits a 100% increase in electrochemical surface area (ECSA) and a 160% enhancement in intrinsic OER activity compared to commercial Ir black catalysts. The optimized Ir anode achieved a current density of 3.0 A cm −2 at 1.69 V (0.2 mg Ir cm −2 ) and 1.73 V (0.1 mg Ir cm −2 ) in membrane electrode assemblies (MEAs), exceeding the US DOE 2026 targets (0.5 mg PGM cm −2 at 1.8 V for 3.0 A cm −2 ). The corresponding MEAs also demonstrated compelling long-term durability, as evidenced by a low voltage degradation rate of 26 µV h −1 over 1100 hours of operation and 0.8 µV cycle −1 during an accelerated stress test.}, archive = {J_ANGEW}, author = {Jiashun Liang and Jiamao Zheng and Dominik Wierzbicki and Shuo Liu and Guofeng Wang and Chaochao Dun and Gang Wu}, doi = {10.1002/anie.202512317}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512317}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhenium-doping to promote structural evolution of metallic iridium to oxides on platinum nanowire bundles for acidic oxygen evolution}, volume = {64}, year = {2025}, }
• (2025). Metallaphosphirenes with σ-aromaticity: Capture of phosphorus atom by metalla-aromatics. ANGEW, 64(38), e202512214. (www)

  @article{ , abstract = {Unsaturated phosphorus heterocycles typically exhibit diminished π-aromaticity. A unique entry into metallaphosphirenes featuring σ-aromaticity within an unsaturated framework is reported. Reaction of sodium phosphaethynolate (NaOCP) with cyclic metal carbyne 1 affords phosphorus atom transfer through a formal [1 + 2] cycloaddition pathway. The formation of metallaphosphirene ring was computationally modelled using density functional theory, revealing that [1 + 2] cycloaddition involves direct nucleophilic attack step and, thus, depends on the amphiphilicity of carbyne atom. Comprehensive DFT calculations, including NICS, ACID, GIMIC, EDDB, and NOBD analysis, confirm the predominantly σ-aromatic nature of the metal-based phosphirene system. The reactivity of the metallaphosphirene in cycloaddition reactions is in accord with its σ-aromaticity, which tends to retain the three-membered heterocycle with λ 3 -P atom.}, archive = {J_ANGEW}, author = {Xin Yang and Xiaoyan Zhang and Yapeng Cai and Haiping Xia and Hong Zhang}, doi = {10.1002/anie.202512214}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512214}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metallaphosphirenes with σ-aromaticity: Capture of phosphorus atom by metalla-aromatics}, volume = {64}, year = {2025}, }
• (2025). Multiresonant framework-perturbed Platinum(II) complexes enable efficient narrowband red phosphorescence emissions. ANGEW, 64(38), e202512098. (www)

  @article{ , abstract = {While considerable research efforts have been devoted to developing narrowband B,N-embedded multiple resonance (BN-MR) emitters, despite the formidable challenge, the design of efficient narrowband red phosphors has been overlooked. Herein, we present a design strategy that perpendicularly integrates BN-MR frameworks into a weakly emissive tetradentate Pt(II) complex to achieve efficient narrowband phosphors. Accordingly, we synthesized two novel emitters, BCzBN-PyPt and DPABN-PyPt. The optimized emitter BCzBN-PyPt exhibits exceptional performance characteristics: 1) narrowband red emission at 605 nm with a small full-width at half-maximum (FWHM) of 35 nm/0.118 eV in toluene, 2) a dramatically shortened exciton lifetime of 1.2 µs (compared to 7.6 µs for the parent complex PhPyPt), and 3) a remarkable photoluminescence quantum yield ( Φ PL ) of 75% in doped films–representing a 4.4-fold enhancement over PhPyPt ( Φ PL = 17%). Theoretical investigations reveal that the BN-MR skeleton induces significant electronic perturbation of the singlet state, leading to enhanced transition dipole moments and accelerated radiative decay ( k r = 3.3 × 10 5 s −1 versus 0.1 × 10 5 s −1 for PhPyPt). In optimized OLED devices, BCzBN-PyPt achieves superior red narrowband electroluminescence with a maximum external quantum efficiency of 22.7%.}, archive = {J_ANGEW}, author = {Qinze Zheng and Ke Du and Xian-Kai Chen and Yuxuan He and Ge Gao and Zhengyang Bin}, doi = {10.1002/anie.202512098}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202512098}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiresonant framework-perturbed Platinum(II) complexes enable efficient narrowband red phosphorescence emissions}, volume = {64}, year = {2025}, }
• (2025). Ru-RuO2 coordinated with si-supported GaN nanowires for light-driven simultaneous activation of CO2 and h2 to achieve exceptional reverse Water–Gas shift reaction. ANGEW, 64(38), e202511886. (www)

  @article{ , abstract = {The reverse water–gas shift (RWGS) reaction presents an industrial promise for carbon dioxide valorization. In this work, a dual-site Ru-RuO 2 cocatalyst anchored on Si-supported GaN nanowires (NWs) is developed for solar-powered CO 2 -to-CO conversion. The assembled Si-supported GaN NWs/Ru-RuO 2 delivers a considerable CO rate of 57.89 mmol·cm −2 ·h −1 with nearly 100% selectivity under illumination at 5.5 W·cm −2 without external heating, along with a remarkable turnover frequency of 2.28 × 10 5 h −1 . The temperature-programmed desorption, in situ spectroscopic characterization, and DFT calculations collectively reveal that the Si-supported GaN NWs/Ru-RuO 2 enables simultaneous activation of CO 2 and H 2 . Moreover, the synergy between Ru-RuO 2 and GaN substantially reduces the reaction energy barrier from 0.83 to 0.64 eV via the key *COOH intermediate, thereby establishing a new benchmark for light-driven RWGS efficiency. This work provides a strategic design for high-performance CO 2 -to-CO conversion and opens avenues for downstream synthetic applications.}, archive = {J_ANGEW}, author = {Jiaming Liu and Zijian Huang and Xiantong Zheng and Muhammad Salman Nasir and Ding Wang and Ping Wang and Jinglin Li and Yixin Li and Lei Zhu and Xinqiang Wang and Zhen Huang and Baowen Zhou}, doi = {10.1002/anie.202511886}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511886}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ru-RuO2 coordinated with si-supported GaN nanowires for light-driven simultaneous activation of CO2 and h2 to achieve exceptional reverse Water–Gas shift reaction}, volume = {64}, year = {2025}, }
• (2025). Triadic electrophilic centers specifically bind to SMO transmembrane domain to inhibit the hedgehog pathway. ANGEW, 64(38), e202511720. (www)

  @article{ , abstract = {Designing drugs to target overexpressed membrane protein smoothened (SMO) to selectively inhibit the Hedgehog signaling pathway represents a promising approach to achieving effective chemotherapy. Currently, only three organic small molecular inhibitors of SMO have been approved for clinically targeted therapy. Herein, we demonstrate a novel strategy to anchor SMO by designing metallodrugs ( RuSe , OsSe , RuIP , OsIP ) containing triadic electrophilic centers (─N(δ − )─X(δ + )─N(δ − )─). In vitro and in vivo experiments validated that the designed triadic electrophilic center drugs could selectively inhibit the activity of SMO, blocking the Hedgehog signaling pathway and effectively killing tumors. Through theoretical calculations combined with experimental data, we verified that the interaction between the protein and drugs increases the polarization of the triadic electrophilic centers. The drugs utilize dual electrophilic centers to fix the binding and use the third electrophilic center insert to the swinging hinge region between TM5 and TM6 of the 7-transmembrane domain of SMO. This strengthens the π-cation lock binding between the transmembrane peptide chains, ultimately inhibiting the mobility of the transmembrane peptide chains and thereby inhibiting SMO activity. This work provides a new strategy for designing SMO specific targeted drugs, offering new hope for clinically targeted therapies.}, archive = {J_ANGEW}, author = {Fei Cai and Jin Zhang and Hui Li and Jinrong Dong and Peng Xie and Hanlong He and Junxian Guo and Mingkai Chen and Ligeng Xu and Li Ma and Tianfeng Chen}, doi = {10.1002/anie.202511720}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511720}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triadic electrophilic centers specifically bind to SMO transmembrane domain to inhibit the hedgehog pathway}, volume = {64}, year = {2025}, }
• (2025). Multisite cooperative regulation of solvation and interface via dynamic additive engineering for highly reversible zinc batteries. ANGEW, 64(38), e202511685. (www)

  @article{ , abstract = {Inexhaustible additives have been reported to enhance the reversibility of aqueous zinc-ion batteries (AZIBs). However, the structure–performance relationship of additive molecules remains elusive, particularly regarding multisite coordination-mediated synergistic regulation of solvation and interface. Herein, a dynamic configuration reconstruction mechanism that orchestrates the multisite regulation of solvation and interface is unveiled by utilizing a series of polyhydroxy additive prototypes, demonstrating that the increase of functional groups and chain flexibility in multifunctional-group molecules (MGMs) contributes to boosting battery performance. MGM with folded configuration engages in multisite Zn 2+ coordination in the solvation shell, effectively minimizing active H 2 O molecule to suppress parasitic reactions, while its configuration transition to straight-chain architecture enables multisite parallel adsorption on Zn anode interface, thus accelerating desolvation kinetics and steering (002)-facet-dominated Zn deposition. Remarkably, Zn//Zn cells achieve long cycle life of 7000 h and subzero-temperature operation, and Zn//PANI pouch cell maintains nearly 100% capacity retention after 500 cycles. This work opens a fascinating avenue for developing high-performance batteries via dynamic additive engineering.}, archive = {J_ANGEW}, author = {Mengke Su and Haozhen Dou and Jinliang Yan and Sitong Liu and Mi Xu and Chuangwei Liu and Xin Wang and Zhongwei Chen}, doi = {10.1002/anie.202511685}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511685}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multisite cooperative regulation of solvation and interface via dynamic additive engineering for highly reversible zinc batteries}, volume = {64}, year = {2025}, }
• (2025). C─C bond formation via reductive elimination at rare earth centers. ANGEW, 64(38), e202511551. (www)

  @article{ , abstract = {Reductive elimination is one of the most important elementary reactions employed for constructing various chemical bonds in transition metal complex-mediated transformations. However, due to the lack of two-electron transfer, rare earth (RE) centers have been considered incapable of promoting reductive elimination, thus limiting the reactivity of RE complexes and their applications in synthetic chemistry. In the presented study, we demonstrated the reactions of β -diketiminate-supported dialkyl RE(III) complexes (L Nacnac - κ 2 N , N′ )RE(III)(CH 2 SiMe 3 ) 2 (THF) ( 1-RE , RE = Y, Er, Yb, and Lu; L Nacnac = {[(2,4,6-Me 3 C 6 H 2 )NCMe] 2 CH} − ) with azobenzene at ambient conditions, resulting in the formations of (L Nacnac - κ 2 N,N′ )RE(III)( η 2 - cis -PhNNPh −• ) 2 (THF) ( 2-RE ) and 2-[(trimethylsilyl)methyl]azobenzene ( I ) via a reductive elimination-powered pathway. The key intermediate (L Nacnac - κ 2 N,N' )Lu(III)(PhNNC 6 H 5 - κ 2 N,C )(CH 2 SiMe 3 ) ( 3-Lu ), which is formed via ortho -H deprotonation in azobenzene by the (trimethylsilyl)methyl group in 1-Lu , was isolated and structurally identified. The computational studies indicate that the subsequent η 2 -coordination of a cis -azobenzene to the RE(III) centers in this intermediate triggers the reductive elimination between the (trimethylsilyl)methyl group and the neighboring PhNNC 6 H 5 - κ 2 N,C group, consequently enabling the C─C cross-coupling that affords product I . In this elementary process, the two N═N π *-orbitals mainly act as the energetically accessible acceptors for the two electrons being transferred, thereby facilitating the reductive elimination by avoiding the thermodynamically unfavorable 2e-reductions of RE centers.}, archive = {J_ANGEW}, author = {Changjiang Wu and Hui Guo and Bingjian Feng and Songyi Li and Tianlin Zhou and Yingzhuang Xu and Jie Zhang and Peng Cui and Yinshan Meng and Huayi Fang and Chunhua Yan}, doi = {10.1002/anie.202511551}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511551}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C─C bond formation via reductive elimination at rare earth centers}, volume = {64}, year = {2025}, }
• (2025). Controllable preparation of hierarchically charge-separated interface to effectively promote the desolvation and kinetics of lithium ions. ANGEW, 64(38), e202511502. (www)

  @article{ , abstract = {Solid-electrolyte interphase (SEI) is one of the key factors to determine the performance of batteries. Electrolyte additives enhance SEI performance for fast charging and long cycle life but introduce system-level uncertainties, including cathode degradation, safety hazards, and cost escalation. In this study, we prepare a composite electrode (BPQDs/GDYNTs) featuring a charge-separated interface structure to improve the SEI directly without auxiliary additives. The BPQDs/GDYNTs are comprised of graphdiyne tubes (GDYNTs) with black phosphorus quantum dots (BPQDs) distributed on the surface. The charge transfer between BPQDs and GDYNTs creates a charge-separated interface, thereby enabling the efficient adsorption of lithium (Li) ions by the electron-rich state of GDYNTs while promoting the adsorption of hexafluorophosphate anion (PF 6 − ) on the electron-deficient state of BPQDs. That facilitates the in situ formation of a thin and inorganic-rich SEI containing fluorine- and phosphorus-based species, which significantly enhances both the desolvation of Li-ions and their kinetics. When utilized as the anode of Li-ion batteries, the BPQDs/GDYNTs electrode exhibits fast-charging capability and remarkable longevity, demonstrating ultra-stable cycling performance over 50 000 cycles at a high current density of 10 A g −1 with negligible capacity decay.}, archive = {J_ANGEW}, author = {Qian Chang and Changshui Huang and Zhihui Zhang and Feng He and Xinlong Fu and Yuliang Li}, doi = {10.1002/anie.202511502}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controllable preparation of hierarchically charge-separated interface to effectively promote the desolvation and kinetics of lithium ions}, volume = {64}, year = {2025}, }
• (2025). Full-dimensional control of covalent organic frameworks through repulsion-torsion effect: Prominent 1D above 2D and 3D structures. ANGEW, 64(38), e202511501. (www)

  @article{ , abstract = {Exploring the impact of different dimensions on the properties and functions of covalent organic frameworks (COFs) has always been a key goal, as this can provide feedback to assist in the design of advanced COFs. However, this goal has never been performed simultaneously in one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) COFs, due to the difficulty of dimensional control. Herein, for the first time, we synthesized three novel COFs with different dimensions, from similar composition by manipulating the conformation of the molecular building blocks through repulsion-torsion effect. Impressively, the strong repulsion-torsion effect transformed the planar building block into a non-planar building block, resulting in the construction of 2D and 3D COFs, respectively. Moreover, when we consciously reduced the repulsion-torsion effect, the resulting intramolecular conformation struggled to meet the requirements for the formation of 2D and 3D structures, ultimately generating a rare 1D COF. Further research indicated the charge transfer efficiency and photocatalytic performance of the resulting COFs followed a dimensional order of 1D > 3D > 2D. This phenomenon was attributed to the unique in-plane and out-of-plane double rotational restriction (IODRR) effect in the 1D structure, which stabilized the aromatic framework and thus greatly reduced the carrier recombination probability and energy loss.}, archive = {J_ANGEW}, author = {Kaifu Yu and Pan He and Dong Zhang and Hongqing Wu and Kewen Shu and Honghan Long and Yubang Sun and Xiang Pei and Bo Jiang and Kecheng Cao and Yang Li and Lijian Ma}, doi = {10.1002/anie.202511501}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511501}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Full-dimensional control of covalent organic frameworks through repulsion-torsion effect: Prominent 1D above 2D and 3D structures}, volume = {64}, year = {2025}, }
• (2025). Continuous photocatalytic acetylene conversion to ethylene in liquid under ambient conditions. ANGEW, 64(38), e202511422. (www)

  @article{ , abstract = {Ethylene is a basic building block for polymer synthesis, but its purification from petroleum-based processes (e.g., thermo-catalytic acetylene hydrogenation) and its production from coal-based processes (e.g., Fischer–Tropsch synthesis) normally require high temperature, high pressure, and gaseous hydrogen. Here, we report a continuous ethylene photosynthesis approach as a new platform technology that enables highly efficient and selective conversion of acetylene to ethylene in liquid under mild conditions. This platform technology is compatible with a wide range of solvents, catalysts, and hydrogen sources. Using Pd/mpg-C 3 N 4 as the model photocatalyst, a complete conversion of acetylene was achieved with high ethylene selectivity (>93%) under the continuous flow of either a pure acetylene stream or a crude ethylene stream containing acetylene impurity. The process performance remained stable for at least 72 h. Physical, theoretical, and in situ spectroscopy investigations showed that the photocatalytic acetylene hydrogenation follows the proton-coupled electron transfer (PCET) and atomic hydrogen-mediated indirect electron transfer pathways with proton as the hydrogen source. The technoeconomic analysis (TEA) demonstrated that this photocatalytic approach has large profitable margins for both ethylene purification and ethylene production processes. This study provides a green and sustainable technology for both petrochemical (ethylene purification) and coal-chemical (ethylene production) industries.}, archive = {J_ANGEW}, author = {Xiaojia Lei and Chao Lei and Xuxu Wang and Wenqian Chen and Qian Guo and Yongyou Hu and Jianbo Liu and Tiefeng Wang and Binbin Huang}, doi = {10.1002/anie.202511422}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511422}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Continuous photocatalytic acetylene conversion to ethylene in liquid under ambient conditions}, volume = {64}, year = {2025}, }
• (2025). Experimentally guided iterative parameter estimation for predictive chemical oscillator models. ANGEW, 64(38), e202511413. (www)

  @article{ , abstract = {Chemical oscillators are fundamental to dynamic processes in biology, from circadian rhythms to metabolic regulation, inspiring efforts to design synthetic analogues for use in responsive materials, autonomous systems, and molecular computing. However, creating robust and tunable synthetic oscillators remains a major challenge due to the inherent complexity and difficulty of identifying conditions that support sustained oscillations. We herein describe an iterative approach based on mathematical modeling and parameter estimation guided by live experimental data to accurately model the oscillating chemical network. Fitting a kinetic model to the whole chemical network proves considerably more effective and time-efficient than determining reaction rates individually and enables quick screening of various parameters. We apply this method to achieve sustained oscillations in flow when changing various aspects of our recently developed oscillating system, demonstrating its potential to facilitate the development and optimization of organic oscillators as well as offering a general framework for analyzing and optimizing complex synthetic CRNs.}, archive = {J_ANGEW}, author = {Maëlle Le Cacheux and Luca E. Oddone and Sofiya A. Runikhina and Johanan Kootstra and Andreas Milias-Argeitis and Syuzanna R. Harutyunyan}, doi = {10.1002/anie.202511413}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511413}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Experimentally guided iterative parameter estimation for predictive chemical oscillator models}, volume = {64}, year = {2025}, }
• (2025). Improved ionic thermoelectric performance of adhesive and self-healing cationic high-entropy gel thermocell. ANGEW, 64(38), e202511293. (www)

  @article{ , abstract = {Gel thermocell can directly convert heat into electricity by ions as energy carriers, capable of low-grade heat harvesting. However, ionic thermoelectric performance, including ionic thermopower, output power density, and energy density, needs to be significantly improved to meet practical applications. To date, it still lacks an effective strategy to focus on gels to achieve the overall high performance. Herein, an adhesive and self-healing cationic high-entropy gel (CHEG) G-FeCN 4−/3− -K + -Na + -Li + -Gdm + -Cs + in a multi-ion cooperative chemical environment has been designed by the interaction between multications and anions, improving the entropy change of redox reaction, exchange current density, and ionic conductivity, thereby achieving an overall high ionic thermoelectric performance. The CHEG thermocell using the synergy of thermogalvanic and thermodiffusion effects showed a total ionic thermopower of 41 mV K −1 with 2.3 mV K −1 for the former, and delivered a maximum output power density of 14.3 mW m −2 K −2 and an energy density of 4.5 J m −2 K −2 . In addition, an ultrahigh maximum output power density of 4.13 mW m −2 K −2 was obtained in the CHEG device that was assembled by connecting four thermocells in series, which could realize electrocatalytic degradation of rhodamine B. This work demonstrates a feasible way to design high-performance ionic thermoelectric gels and provides a new application in water pollution treatments.}, archive = {J_ANGEW}, author = {Lijuan Yang and Jiawei Chen and Wenjun He and Guimei Li and Chunxia Xie and Wei Wang and Dongxue Han and Cheng-Gong Han and Li Niu}, doi = {10.1002/anie.202511293}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511293}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improved ionic thermoelectric performance of adhesive and self-healing cationic high-entropy gel thermocell}, volume = {64}, year = {2025}, }
• (2025). Single-site metal-nonmetal microenvironment regulation of copper nanoclusters with atomic precision for X-ray imaging. ANGEW, 64(38), e202511261. (www)

  @article{ , abstract = {The intramolecular microenvironment regulation in metal nanoclusters has typically occurred with the same attribute factors—like metal-to-metal or ligand-to-ligand control—while the regulation with different-attribute factors, e.g., from metal to nonmetal, remains challenging, not to mention the different-attribute microenvironment regulation at the single-site level. Herein, we report the single-site metal-nonmetal microenvironment regulation of copper nanoclusters based on structurally comparable Cu 10 and Cu 11 nanoclusters with the same skeleton but different vacancy-filling elements. The quantum-size effects endow Cu 10 and Cu 11 with distinctly different photophysical properties in terms of their photoluminescence and radioluminescence. Such differences have been rationalized by exploiting the femtosecond transient absorption analysis, demonstrating that the slower non-radiative decay rate and weaker electron-phonon coupling contribute to the superior emission characteristics of the Cu 11 cluster. Accordingly, the Cu 11 -based film demonstrated effective X-ray imaging capabilities, marking the first application of cluster-based nanomaterials for X-ray imaging in the infrared region. This research highlights the potential for regulating different-attribute microenvironments in metal nanoclusters and provides an atomic-level understanding of how to modulate the photophysical properties of cluster-based nanomaterials.}, archive = {J_ANGEW}, author = {Chen Zhu and Fei Li and Jingjing Xia and Zhongren Shi and Mingshuai Yu and Weinan Dong and Siqi Li and Zhijia Hu and Zhennan Wu and Xi Kang and Manzhou Zhu}, doi = {10.1002/anie.202511261}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511261}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-site metal-nonmetal microenvironment regulation of copper nanoclusters with atomic precision for X-ray imaging}, volume = {64}, year = {2025}, }
• (2025). Biomimetic gourd-vine supramolecular engineering for high-performance organic cathode through dual-mode of anion coordination and conjugated redox activation. ANGEW, 64(38), e202511229. (www)

  @article{ , abstract = {P-type organic cathode materials feature multielectron redox activity, structural tunability, and elevated redox potentials, making them promising candidates for battery applications. Nevertheless, their practical deployment remains hindered by inherent challenges, particularly the persistent dissolution issue in conventional electrolytes, leading to rapid capacity fading. To overcome these intrinsic limitations, we propose a biomimetic supramolecular engineering strategy inspired by the hierarchical reinforcement observed in gourd-vine systems, which integrates two synergistic design principles. First, the alkyl-based polymeric backbone and π−π stacking impose steric confinement to suppress solvation-driven degradation. Second, the conjugated aryl groups strategically are positioned on the phenazine scaffold to enhance charge delocalization and activate redox-active nitrogen sites. This approach not only endows the battery system with exceptional long-term cycling stability but also enables high-capacity energy storage with sustained operational durability. The resultant 5,10-diaryl-5,10-dihydrophenazine polymer cathode exemplifies this paradigm, demonstrating outstanding electrochemical performance including an impressive reversible capacity of approximately 120 mAh g −1 at 100 mA g −1 and an excellent capacity retention of 88% over 2000 cycles, representing one of the most robust performances reported for organic cathodes. Comprehensive characterizations combined with theoretical simulations systematically elaborate a dual-mode charge compensation mechanism involving the reversible anion (de)coordination coupled with conjugated π-electron redox activation.}, archive = {J_ANGEW}, author = {Xianchun Liu and Jian Shang and Yan Cheng and Qingguang Pan and Jia Li and Chun-Hua Liu and Hanlin Liu and Fan Zhang and Yuan-Yuan Zhu and Tao Liu and Yongbing Tang}, doi = {10.1002/anie.202511229}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511229}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biomimetic gourd-vine supramolecular engineering for high-performance organic cathode through dual-mode of anion coordination and conjugated redox activation}, volume = {64}, year = {2025}, }
• (2025). Stabilizing cu3+ active center by intramolecular electron transfer for boosting complete glucose electrooxidation. ANGEW, 64(38), e202511103. (www)

  @article{ , abstract = {The development of effective electrocatalysts for glucose (Glu) electro-conversion is highly desirable for sensing applications; however, is greatly plagued by unstable catalytic active centers during the catalytic process, leading to severe inactivation of active sites and incomplete Glu electrooxidation. Herein, we report a class of single-atom Pt-doped Cu-based metal-organic frameworks (MOFs) with stable high-valence Cu sites (CuO-MOF-Pt 1 ), achieving a complete oxidation of Glu and a milliampere current response toward Glu. We demonstrate that the –CN of MOF and Pt serve as electron-withdrawal sites to induce electron transfer of the Cu site, promoting the electrochemical generation of the stabilized Cu 3+ active center. Using operando spectroscopy and computation, we uncover that a complete glucose electrooxidation reaction (GOR) can be achieved by successive C─C bond scission over CuO-MOF-Pt 1 , and a stable Cu 3+ active center is responsible for its impressive GOR activity. Notably, CuO-MOF-Pt 1 delivers comparable Glu sensing performance with a high sensitivity of 2.587 mA mM −1 cm −2 , a low detection limit of 0.93 µM, and extraordinary durability. We further constructed a miniaturized CuO-MOF-Pt 1 -based sensor, enabling accurate detection of Glu in saliva. This work opens an inspiring avenue to the precise design of stable metal activity centers through electronic structure regulation for boosting Glu electrooxidation.}, archive = {J_ANGEW}, author = {Rui Zheng and Long Pang and Zhangquan Peng and Dongyang Qu and Yu Bao and Huiliang Sun and Zhonghui Sun and Shaojun Guo and Li Niu}, doi = {10.1002/anie.202511103}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511103}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilizing cu3+ active center by intramolecular electron transfer for boosting complete glucose electrooxidation}, volume = {64}, year = {2025}, }
• (2025). Exciton trapping at shape-persistent molecular nanotubes. ANGEW, 64(38), e202511093. (www)

  @article{ , abstract = {We report a series of shape-persistent molecular nanotubes with top rim connectivity traversing from an all- meta - ( m 4 ) to an all- para -phenylene ( p 4 ) bridged species, including all possible members in between them. Single-crystal X-ray diffraction (SCXRD) and microcrystal electron diffraction (MicroED) data show a large torsional angle for meta -phenylenes relative to para -phenylene rings. Density functional theory (DFT) calculations reproduce the experimental torsional angles and also establish a correlation indicating a gradual increase in strain energy from m 4 (∼31 kcal mol −1 ) to p 4 (∼90 kcal mol −1 ). Structural transitions from m 4 to p 4 lead to additional correlations such as a shift in the lowest absorption wavelength from 330 to 394 nm, a sizeable red shift in the maximum emission wavelength from 444 to 546 nm, and a decrease in fluorescence quantum yield from 0.76 to 0.20, respectively. Time-dependent (TD)-DFT analysis of the relaxed excited state (S 1’ ) geometry shows a progression of exciton delocalization as para -phenylenes are introduced into m 4 en route to p 4 , while the overall molecular size remains constant. This effect is directly related to increased π-conjugation within the nanotube's top-segment and demonstrates how exciton trapping can take place without changing the nanotube's physical size, e.g., diameter and length.}, archive = {J_ANGEW}, author = {Victor M. Espinoza Castro and Saber Mirzaei and Mohammad Bilal and Gabriella N. Ruiz and Michael J. Rose and Xu Wang and Raúl Hernández Sánchez}, doi = {10.1002/anie.202511093}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511093}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exciton trapping at shape-persistent molecular nanotubes}, volume = {64}, year = {2025}, }
• (2025). Metastable macrocyclic bis-meisenheimer adduct. ANGEW, 64(38), e202511037. (www)

  @article{ , abstract = {An electron-deficient tetranitroazacalixarene is shown to undergo reversible cyanide capture via nucleophilic aromatic substitution, yielding an unprecedented class of metastable dianionic macrocycle incorporating two Meisenheimer units, fully characterized by single-crystal X-ray diffraction, NMR, and electronic absorption spectroscopies. Acting as a chemical fuel, cyanide transiently drives the formation of this adduct, which can spontaneously regenerate the parent macrocycle under mild conditions, representing a rare demonstration of metastability in a Meisenheimer complex. The dynamic behavior of this system, reminiscent of out-of-equilibrium assemblies, is finely tunable through macrocycle concentration, counterion nature, solvent, and temperature. Detailed crystallographic, spectroscopic, and computational analyses reveal that intramolecular hydrogen bonding plays a key role in stabilizing the adduct. Comparative studies with simpler analogues further highlight the importance of macrocyclic preorganization and non-covalent interactions in governing this reversible reactivity.}, archive = {J_ANGEW}, author = {Simon Pascal and Angélina Torres Ruiz and Aerin E. Baker and Douglas A. Vander Griend and Michel Giorgi and Aurélien Planchat and Denis Jacquemin and Olivier Siri}, doi = {10.1002/anie.202511037}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202511037}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metastable macrocyclic bis-meisenheimer adduct}, volume = {64}, year = {2025}, }
• (2025). Phase transition-induced regulation of room temperature phosphorescence and delayed fluorescence in doping system. ANGEW, 64(38), e202510781. (www)

  @article{ , abstract = {Switching between triplet-involved room temperature phosphorescence (RTP) and delayed fluorescence (DF) is pivotal for advancing molecular encryption application but remains a significant challenge in multicomponent material systems. In this study, we successfully realized the selective modulation of RTP and DF emissions in a donor-acceptor doping system by inducing conformational changes in the donor through solid-liquid transition. In the solid state, the donor adopts a highly twisted quasi-axial conformation, which effectively suppresses non-radiative decay, resulting in efficient green RTP. In contrast, in the liquid state, the donor transitions to a relatively planar conformation, forming the intermolecular charge transfer state with the acceptor, significantly reducing the energy gap between the lowest singlet and triplet excited states, thereby facilitating reverse intersystem crossing (RISC) and generating yellow DF. Furthermore, the coexistence of multiple emissive triplet states demonstrates promising applications in information encryption, ink-free rewritable paper, and thermal sensing.}, archive = {J_ANGEW}, author = {Chenxiao Li and Yuteng Feng and Yue Feng and Yuehui Lin and Na Wang and Kun Liu and Qiuzhuo Dong and Chengguang Huang and Huifang Shi and Kang Shen and Wei Yao and Huili Ma and Zhongfu An and Wei Huang}, doi = {10.1002/anie.202510781}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510781}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phase transition-induced regulation of room temperature phosphorescence and delayed fluorescence in doping system}, volume = {64}, year = {2025}, }
• (2025). In situ tracking of ni-MOF reconstruction into active Ni(OH)2 OER catalysts. ANGEW, 64(38), e202510741. (www)

  @article{ , abstract = {The oxygen evolution reaction (OER) remains a key bottleneck in electrochemical energy storage and conversion. In this work, we demonstrate the transmutation of a Ni-based metal-organic framework (Ni-MOF), composed of one-dimensional Ni–( μ 3 -OH)/( μ 2 -H 2 O)–Ni chains interconnected by 1,4-ndc linker, into catalytically active β -Ni(OH) 2 . This top-down reconstruction strategy involves the disintegration of 1,4-ndc linker and transformation of 1D Ni–( μ 3 -OH)/( μ 2 -H 2 O)–Ni chains (which act as precursors), into ultra-low-dimensional (thickness ∼ 1.5–2.6 nm), defect-rich β -Ni(OH) 2 structure. The activated catalyst achieves a low overpotential of 300 mV at 10 mA.cm −2 , surpassing commercial IrO 2 . In situ Raman and powder diffraction studies demonstrate pH- and potential-dependent phase transitions, leading to the formation of catalytically active β -Ni(OH) 2 . In situ X-ray absorption spectroscopy (XAS) confirms progressive structural evolution, with a Ni─O bond contraction from 2.06 to 1.89 Å under catalytic conditions, indicative of dynamic NiOOH phase formation. Density functional theory (DFT) calculations reveal that the exposed Ni 2+ centers stabilize OER intermediates and facilitate the adsorbate oxygen evolution mechanism (AEM). The catalyst also demonstrates robust activity at elevated temperatures. This work provides extensive mechanistic insights into catalyst activation and introduces a novel strategy for designing high-performance MOF based OER electrocatalysts.}, archive = {J_ANGEW}, author = {Rohan Jena and Varchaswal Kashyap and Rajkumar Jana and Tamagna Mandal and Tarak Nath Das and Faruk Ahamed Rahimi and Soumitra Barman and Dipanjan Maity and Ravi Kumar and Dibyendu Bhattacharyya and Ayan Datta and Tapas Kumar Maji}, doi = {10.1002/anie.202510741}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510741}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ tracking of ni-MOF reconstruction into active Ni(OH)2 OER catalysts}, volume = {64}, year = {2025}, }
• (2025). Multisite proton-coupled electron transfer facilitates oxidative photocatalysis in a molecular zr-based coordination compound. ANGEW, 64(38), e202510723. (www)

  @article{ , abstract = {The development of mediators that harness visible light to drive proton-coupled electron transfer (PCET) offers a promising pathway to achieving challenging redox transformations in a more sustainable manner and with enhanced thermochemical efficiency. However, designing photocatalytic systems based on earth-abundant metals while gaining precise control over their excited-state reactivity remains a significant challenge. Here, deprotonation of the hydroxy ligands in the Zr₃(O)(OH)₃ nodes of a photoactive coordination cage is shown to unlock the photocatalytic oxidation of strong O─H and C─H bonds (70–100 kcal mol⁻ 1 ). Mechanistic investigations reveal that this oxidative process proceeds via a multisite PCET pathway involving ground-state, pre-association followed by a static quenching mechanism. This contrasts with the dynamic quenching mechanism governing the reductive PCET previously reported for the same system. Collectively, these findings establish an unprecedented ambipolar PCET mechanism with a new class of photocatalytic mediators based on an earth abundant metal.}, archive = {J_ANGEW}, author = {Mercedes Moreno-Albarracín and Alvaro M. Rodriguez-Jimenez and Omar Nuñez and Pablo Garrido-Barros}, doi = {10.1002/anie.202510723}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510723}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multisite proton-coupled electron transfer facilitates oxidative photocatalysis in a molecular zr-based coordination compound}, volume = {64}, year = {2025}, }
• (2025). A novel oxygen vacancy in ScPO4:Er for luminescence anti-thermal quenching. ANGEW, 64(38), e202510707. (www)

  @article{ , abstract = {Different from previously reported shallow defects in ScPO 4 , herein we have uncovered a deep defect, oxygen vacancy ( V O ). The perfect energy level match with 4 S 3/2 / 4 F 9/2 in doped Er 3+ allows V O to accept and store the excitation energy transferred from Er 3+ , which is then released and back-transferred to Er 3+ upon heating, and finally leads to significant luminescence anti-thermal quenching (LATQ). Moreover, the concentration of V O can be adjusted by simple atmospheric annealing, which allows modulation of V O → Er 3+ energy transfer for adjustable LATQ in ScPO 4 :Er, i.e., downshifting LATQ up to 843 K and upconversion LATQ till a record-high temperature of 1323 K, and thus unparalleled performance of the classic compound ScPO 4 :Er in thermophotovoltaics (TPV) and dual-mode luminescence thermometers.}, archive = {J_ANGEW}, author = {Hao Song and Hui Wang and Junhe Zhou and Chenyi Wang and Yilin Wang and Hongyu Wang and Xiaobin Tang and Chunxian Tao and Qiuqiang Zhan and Jianhua Liu and Ling Huang}, doi = {10.1002/anie.202510707}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A novel oxygen vacancy in ScPO4:Er for luminescence anti-thermal quenching}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bonded perovskite heterojunction photocatalytic membrane with efficient proton supply for boosting CO2 methanation. ANGEW, 64(38), e202510696. (www)

  @article{ , abstract = {Efficient proton supply and enhanced *CO intermediate adsorption are crucial strategies for boosting CO 2 methanation. Herein, we construct a hydrogen-bonded (H-bonded) photocatalytic membrane by integrating a MAPbBr 3 /cyano-g-C 3 N 4 (MPB/CN-g-CN) heterojunction with ethyl cellulose (ECE) binder through a simple sol–gel process, achieving significantly enhanced CO 2 methanation efficiency. ECE functions as a novel proton source, with hydroxyl (-OH) groups that are readily oxidized by photogenerated holes, resulting in efficient proton supply compared to H 2 O. Moreover, ECE facilitates membrane assembly via interfacial H-bonding between the -OH moieties of ECE and the modified nitrogen sites of MPB/CN-g-CN, generating proton-rich interfaces and local H-bond microenvironments that synergistically enhance proton supply and CO adsorption, thus steering the reaction toward CH 4 production. As a result, the MPB/CN-g-CN membrane achieves a remarkable increase in CH 4 yield from 0.01 to 35.85 µmol g −1 h −1 and selectivity from 0.4% to 82% compared to the pristine heterojunction. Furthermore, the MPB/CN-g-CN/ECE membrane demonstrates exceptional recyclability through a re-crosslinking membrane formation process, effectively reactivating proton-supply sites while maintaining superior CH 4 selectivity across multiple operational cycles.}, archive = {J_ANGEW}, author = {Qiao Chen and Mingzheng Gu and Yixin Hao and Ling Jiang and Guangfeng Wang and Xiaojun Zhang and Feng Hu and Linlin Li and Yuping Wu and Shengjie Peng}, doi = {10.1002/anie.202510696}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510696}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bonded perovskite heterojunction photocatalytic membrane with efficient proton supply for boosting CO2 methanation}, volume = {64}, year = {2025}, }
• (2025). Space-confined electrocatalysis for water splitting: Synthesis, performances, and reaction mechanism of nanomaterials toward high-performance catalysis. ANGEW, 64(38), e202510651. (www)

  @article{ , abstract = {Water splitting represents a sustainable and environmentally benign approach for green hydrogen generation and future clean energy solutions. In this context, space-confined synthesis has emerged as a powerful strategy for engineering high-performance electrocatalysts. Recent studies have demonstrated that low-dimensional nanomaterials synthesized via confinement techniques exhibit enhanced electrocatalytic properties. The confined microenvironment imparts superior electrical conductivity, structural stability, and active site accessibility, while also facilitating elevated catalytic activity and offering potential for scalable production in practical energy applications. In this review, we first present mechanistic insights into nanoconfinement-enhanced water splitting electrocatalysis and characterization techniques including in-situ/ operando analysis for confined electrocatalysts, emphasizing how the confined architectures from one to three dimensions (1D-3D) regulate electronic structures, facilitate reactant adsorption, and reduce energy barriers. We then outline nanoscale confinement strategies, including in-situ and postsynthetic approaches using diverse host materials such as carbon nanotubes (CNTs), metal–organic frameworks (MOFs), and MXenes, along with advanced methods for controlling particle dispersion and size. Next, we summarize recent progress in confined electrocatalysts for water splitting, highlighting density functional theory (DFT)-guided design and structure–property relationships. Finally, we address current challenges and future opportunities in synthesis control, in-situ characterization, and scalable deployment for practical hydrogen production.}, archive = {J_ANGEW}, author = {Feiwu Zhang and Siyuan Niu and Yuxin Zhao and Changqing Li and Zhongping Li and Siliu Lyu and Yang Hou and Jong-Beom Baek}, doi = {10.1002/anie.202510651}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Space-confined electrocatalysis for water splitting: Synthesis, performances, and reaction mechanism of nanomaterials toward high-performance catalysis}, volume = {64}, year = {2025}, }
• (2025). Compact ion-pair aggregates dominated electrolytes enable high-performance low-temperature lithium-ion batteries. ANGEW, 64(38), e202510647. (www)

  @article{ , abstract = {Lithium-ion batteries (LIBs) are widely used due to their high energy density, long cycle life, and environmental friendliness. However, at sub-zero temperatures, the operation of LIBs is constrained by degraded electrolyte ion transport performance and severe charge transfer polarization. In this work, we proposed a strategy for the construction of solvation structures dominated by compact ion-pair aggregates (CIPAs) through weak lithium-solvent interactions design, which significantly improved the lithium-ion transference number and reduced the de-solvation energy barrier. Excitingly, this strategy can induce the formation of a robust anion-derived solid electrolyte interface, thereby enabling the rapid transport of lithium ions across the interface even at extremely low temperatures. This electrolyte provides excellent electrochemical performance of practical natural graphite and LiNi 0.8 Co 0.1 Mn 0.1 (NCM811) electrodes. The NCM811||graphite full cell exhibits capacity retention of 84.7% of its room temperature capacity at a high rate of 0.5C at −20 °C, and can be cycled stably for over 200 cycles at −40 °C without obvious capacity degradation. This work presents an innovative avenue for high performance LIBs at low temperature.}, archive = {J_ANGEW}, author = {Feng Su and Yiting Lin and Xin Dou and Haipeng You and Shang Gao and Zheng Bai and Jiajun Jiang and Long Chen and Chunzhong Li}, doi = {10.1002/anie.202510647}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510647}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Compact ion-pair aggregates dominated electrolytes enable high-performance low-temperature lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Electrostatic potential-dominated weak solvation chemistry for synergistic optimization of V2O5 cathode and zn anode. ANGEW, 64(38), e202510638. (www)

  @article{ , abstract = {Practical aqueous zinc-ion batteries face severe challenges from cathodic dissolution and anodic dendrite growth. Herein, we report a novel electrostatic potential-dominated weakly solvated electrolyte that correlates molecular charge anisotropy with both solvation thermodynamics and interfacial passivation kinetics. By regulating the electrostatic force among Zn 2+ , H 2 O, and weak solvent, the attack ability of free water on vanadium oxide is efficiently reduced, and the vanadium dissolution is effectively prohibited. Simultaneously, the modified solvating structure induces a dense and inorganic-rich solid electrolyte interface, promoting uniform zinc deposition and suppressing side reactions. Benefiting from such synergistic optimization, the developed zinc-ion battery achieves a high capacity of 410 mAh g −1 and maintains 80% of the capacity after 650 cycles at 0.5 A g −1 . Stable Ah-level pouch cell with high energy density (138 Wh kg −1 , based on electrode mass; 36.3 Wh kg −1 , based on full cell) is also achieved, paving a promising way for practical applications.}, archive = {J_ANGEW}, author = {Jingzhu Chen and Fan Bu and Qinghe Cao and Wenbo Zhao and Yong Gao and Jipeng Chen and Haifei Zhu and Cao Guan}, doi = {10.1002/anie.202510638}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510638}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrostatic potential-dominated weak solvation chemistry for synergistic optimization of V2O5 cathode and zn anode}, volume = {64}, year = {2025}, }
• (2025). Copper single-atom catalyst for efficient C─S coupling in thioether synthesis. ANGEW, 64(38), e202510632. (www)

  @article{ , abstract = {Carbon-heteroatom cross-coupling reactions have become indispensable tools in synthetic chemistry. However, the formation of carbon–sulfur (C─S) bonds, which are essential for producing thioethers used in pharmaceuticals, agrochemicals, and advanced materials, remains significantly underdeveloped. Industrial C─S coupling methods still rely on expensive, homogeneous catalysts that suffer from poor recyclability and are susceptible to sulfur-induced deactivation. In this work, we report a copper single-atom catalyst, where Cu sites are atomically dispersed on mesoporous graphitic carbon nitride, to enable efficient, selective, and recyclable C─S cross-coupling reactions under mild conditions and on a gram scale. The catalyst exhibits excellent resistance to thiol poisoning and maintains high performance over multiple catalytic cycles. Advanced characterization techniques, including aberration-corrected electron microscopy, X-ray absorption spectroscopy, and single-atom-sensitive electron energy loss spectroscopy, confirm the atomic dispersion and stable coordination environment of Cu sites. Combined with density functional theory simulations and radical scavenging experiments, our mechanistic investigations support a concerted oxidative addition pathway, which excludes radical intermediates. These results provide key insights into heterogeneous C─S coupling and demonstrate the power of single-atom catalysts in addressing long-standing challenges in sulfur chemistry, paving the way toward greener and more scalable processes for fine chemical and pharmaceutical synthesis.}, archive = {J_ANGEW}, author = {Theodore A. Gazis and Shilpa Palit and Luis A. Cipriano and Nicolò Allasia and Sean M. Collins and Quentin M. Ramasse and Ik Seon Kwon and Martin Sterrer and Giovanni Di Liberto and Gianvito Vilé}, doi = {10.1002/anie.202510632}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510632}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper single-atom catalyst for efficient C─S coupling in thioether synthesis}, volume = {64}, year = {2025}, }
• (2025). From triplet to twist: The photochemical E/Z-isomerization pathway of the near-infrared photoswitch peri-anthracenethioindigo. ANGEW, 64(38), e202510626. (www)

  @article{ , abstract = {In recent years, large progress has been made to shift the absorption of photoresponsive molecules into the long-wavelength region of the electromagnetic spectrum. A breakthrough in this field was the recent development of -extended indigoid photoswitches, i.e., peri -anthracenethioindigo (PAT), exhibiting all-red and near-infrared addressability. The excited-state isomerization mechanisms of this very new addition to the realm of photoswitching are currently not understood at all, prohibiting a rational further development. In this study, we present a combined theoretical and experimental approach, including time-dependent density functional theory (TD-DFT) and second-order algebraic diagrammatic construction (ADC(2)) calculations as well as steady-state and time-resolved femtosecond spectroscopy, to explore the isomerization pathways of this photoswitch. Our findings show that photoisomerization on singlet potential energy surfaces (PESs) is highly unfavorable and instead show that photoswitching proceeds on the PES. These insights enable a deep understanding of thioindigoid photochemistry and demonstrate that extension of the -system and peri -connectivity in the heterocycle unlock extremely favorable photoswitching properties along with the desirable red-shift in absorption. Reliable photoswitching from the triplet is achieved because of its favorable energy, which evades undesirable interference of oxygen quenching. These results pave the way for advancing thioindigoid-based photoswitches to improved performance and functionality in a rational way.}, archive = {J_ANGEW}, author = {Martina Hartinger and Maximilian Herm and Christoph Schüßlbauer and Laura Köttner and Dirk Guldi and Henry Dube and Carolin Müller}, doi = {10.1002/anie.202510626}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From triplet to twist: The photochemical E/Z-isomerization pathway of the near-infrared photoswitch peri-anthracenethioindigo}, volume = {64}, year = {2025}, }
• (2025). Ionic hydrogen-bonded organic frameworks: A new type of porous organic solid base. ANGEW, 64(38), e202510614. (www)

  @article{ , abstract = {Solid base offers advantages in terms of the ease of handling, environmentally sustainable processes, and tunable interfacial properties. Despite of these benefits, the exploration of new solid bases remains challenging and is an underdeveloped area of research. In this work, we report the discovery of the inherent basicity of hydrogen-bonded organic frameworks (HOFs). The high crystallinity of HOFs enables us to monitor the precise structure changes and proton transfer process during acid-base neutralization reaction through single-crystal X-ray diffraction. With this information, the origin of basicity and the underlying mechanism can be identified, which further guide us to discover other porous solid bases and unveil the universal characteristic of some anionic HOFs. The practical use of the porous solid bases was demonstrated by base-catalyzed reactions, exhibiting high activity and selectivity. This study enriches the solid-base family by introducing a type of materials featured with high porosity, high crystallinity, and modular structure.}, archive = {J_ANGEW}, author = {Ying Hou and Han-Ru Fang and Yu-Lin Li and An-An Zhang and Xin-Song Huang and Lei Cai and Qi Yin and Rui Wang and Jin-Lin Li and Tian-Fu Liu}, doi = {10.1002/anie.202510614}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510614}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ionic hydrogen-bonded organic frameworks: A new type of porous organic solid base}, volume = {64}, year = {2025}, }
• (2025). Synergistic light-ultrasound-driven hydrogen production by hydrogen iodide decomposition over dual-molecular ferroelectric heterostructure. ANGEW, 64(38), e202510596. (www)

  @article{ , abstract = {Emerging catalytic systems for hydrogen production via solar and mechanical energy conversion often face critical challenges, including band mismatch, interfacial charge recombination, and insufficient charge migration driving forces. To address core issues of low carrier separation efficiency and poor multi-field coupling in molecular ferroelectrics, this study proposes a molecular engineering strategy of dual molecular ferroelectric heterojunctions. We report a facile one-pot solution synthesis of a molecular ferroelectric heterojunction composed of 4,4-difluoropiperidinium lead iodide and 4,4-difluorocyclohexylamine lead iodide ((4,4-DFPD) 2 PbI 4 /(4,4-DFCHA) 2 PbI 4 ), tailored for hydrogen iodide (HI) decomposition under simultaneous light -ultrasonic activation. Under dual-field excitation, the heterojunction achieves a remarkable hydrogen evolution rate of 5.26 mmol g −1 h −1 , outperforming its individual constituents ((4,4-DFPD) 2 PbI 4 and (4,4-DFCHA) 2 PbI 4 ) by factors of 4.5 and 2.4, respectively. Kelvin probe force microscopy (KPFM) confirms efficient charge separation at the heterointerface, facilitated by energy-level alignment and polarization coupling. Both experimental and theoretical investigations attribute the enhanced performance to suppressed charge recombination and the synergistic action of ferroelectric and piezoelectric fields, jointly promoting directional charge migration. This work not only introduces a viable molecular ferroelectric strategy for designing high-efficiency piezo-photocatalytic systems but underscores the critical role of interfacial charge dynamics in catalytic optimization, offering theoretical insights and practical guidelines for next-generation solar-driven catalysts.}, archive = {J_ANGEW}, author = {Zi Ning Zhou and Qing Dian Chong and Ya Wen Yang and Zong Wei Hu and Wei Ren and Sheng Sen Zhang and Qiong Ye}, doi = {10.1002/anie.202510596}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510596}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic light-ultrasound-driven hydrogen production by hydrogen iodide decomposition over dual-molecular ferroelectric heterostructure}, volume = {64}, year = {2025}, }
• (2025). Ultrasensitive digital immunoassay in homogenous format by singlet-oxygen activated up-conversion luminescence. ANGEW, 64(38), e202510589. (www)

  @article{ , abstract = {New diagnostic tools for accurately detecting extremely low levels of protein biomarkers in the bloodstream are essential for a wide range of clinical applications. We develop a singlet-oxygen activated up-conversion luminescence assay (SOLA) that enables ultrasensitive digital immunometric detection of protein biomarkers in homogenous format with no wash steps. This approach designs a pair of labeled antibodies, one labeled with a singlet-oxygen ( 1 O 2 ) nanogenerator of porphyrin-metal organic framework (pMOF) and the other tagged using an upconversion nanoparticle (UCNP) nanoreporter with luminescence caged by 1 O 2 -cleavable quenchers. Formation of sandwiched complex between target protein and antibody pairs mediates close proximity between 1 O 2 -generator and UCNP reporter, enabling efficient diffusion of 1 O 2 around the reporter to activate its luminescence through cleaving off the quenchers. This approach is demonstrated to be capable of activating detectable fluorescence from a single UCNP reporter with a single-molecule protein target. A digital homogeneous immunoassay strategy is also developed for ultrasensitive protein detection, allowing a single-step, no-wash format for digital protein detection with high signal-to-background ratio, wide dynamic range and atto-molar detection limit. The SOLA assay may provide an invaluable paradigm for developing highly accessible and ultrasensitive tools for diagnostics and biomarker discovery.}, archive = {J_ANGEW}, author = {Ruiying Peng and Yanli Ji and Daian Chen and Zhan Wu and Jishan Li and Zhaohui Li and Jian-Hui Jiang}, doi = {10.1002/anie.202510589}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrasensitive digital immunoassay in homogenous format by singlet-oxygen activated up-conversion luminescence}, volume = {64}, year = {2025}, }
• (2025). Chiral induction and memory via supramolecular deracemization. ANGEW, 64(38), e202510584. (www)

  @article{ , abstract = {Chirality is intrinsic to nature, and control of molecular chirality remains at the forefront of the chemical sciences. The introduction of fundamentally new principles to break symmetry, leading to the formation of a specific enantiomer, is particularly challenging with important implications in numerous scientific fields. Herein we present a helically chiral dynamic molecular switch whose enantiomers are connected via a single symmetric metastable state that can be populated via light or redox stimuli. Relaxation of the prochiral state in the presence of a bound chiral ammonium guest results in the preferential formation of a specific enantiomer through a conceptually unique supramolecular deracemization process. Importantly, the formed host enantiomer is stable even in the absence of guest, enabling reversible and stable chiral information transfer, while oxidation of the host results in an enantioenriched dication that is insensitive to light, allowing orthogonal chiral memory.}, archive = {J_ANGEW}, author = {Robert Hein and Eric Sidler and Yohan Gisbert and Ben L. Feringa}, doi = {10.1002/anie.202510584}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral induction and memory via supramolecular deracemization}, volume = {64}, year = {2025}, }
• (2025). Electronic cloud topology-driven electrostatic decoupling: To suppress high-voltage parasitic reactions of phosphate cathode in sodium-ion batteries. ANGEW, 64(38), e202510387. (www)

  @article{ , abstract = {The polyanionic structure cathodes with synergistic Mn/V redox couples enables high-voltage platform and delivers considerable theoretical energy density in sodium-ion battery. However, achieving stable and reversible high-voltage redox reactions remain challenging due to the inactivation of redox couples during discharge. Herein, we found that coupled redox behavior triggered by orbitals with similar energy levels leads to high-voltage irreversibility and parasitic reactions. To overcome this, we propose a strategy of adjusting the electron cloud topology by altering the electrostatic field, thereby changing the orbital energy gap between the t 2g state of V and the e g state of Mn, effectively decoupling the electrochemical reactions. As a model system, the Na 3.5 MnV 0.5 Ti 0.5 (PO 4 ) 3 (NMVTP) cathode significantly stabilizes the high-voltage Mn 4+/3+ and V 5+/4+ pairs, and increases the reversible capacity from 99.41 to 123.9 mAh g −1 . This strategy opens new paths for developing high-energy density batteries through orbital bandgap modification.}, archive = {J_ANGEW}, author = {Heng Zhang and Xiao-Tong Wang and Wen-Yu Qian and Zhen-Yi Gu and Yong-Li Heng and Yan Liu and Xin-Ru Zhang and Xin-Yi Zhang and Hong-Jie Zhong and Ning Yu and Dai-Huo Liu and Xing-Long Wu}, doi = {10.1002/anie.202510387}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510387}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic cloud topology-driven electrostatic decoupling: To suppress high-voltage parasitic reactions of phosphate cathode in sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). π-conjugated cations in phosphates: A pathway to solar-blind UV nonlinear optical crystals with phase-matching. ANGEW, 64(38), e202510363. (www)

  @article{ , abstract = {While birefringence phase-matching (PM) remains the most practical approach for nonlinear optical (NLO) frequency conversion, conventional phosphate crystals suffer from intrinsically low birefringence (Δ n < 0.05) that hinders PM behavior in the solar-blind ultraviolet (UV) region ( λ < 280 nm). Herein, we demonstrate a π-conjugated cation engineering strategy to break this limitation, reporting two phosphite-based NLO crystals: (C 2 N 4 OH 7 )H 2 PO 3 (GUPO) and C(NH 2 ) 3 H 2 PO 3 (GPO). The synergistic alignment of π-conjugated guanidinium cations and [H 2 PO 3 ]⁻ anions enables record-breaking optical anisotropy (Δ n = 0.19 @ 589.3 nm for GUPO), surpassing all known inorganic phosphates. Crucially, GUPO is the first phosphate to realize full-wavelength PM, in which the PM wavelength fully covers its optical transparency range down to 215 nm. Concurrently, GUPO exhibits exceptional second-harmonic generation (SHG) response (2.2 × KDP at 1064 nm and 1.0 × β -BBO at 532 nm), which may enable direct 266 nm laser generation. Mechanistic studies reveal that the giant birefringence originates from oriented π–π interactions between cations, while the SHG response stems from the cooperative polarization of cations. This work establishes π-conjugated cation engineering as a paradigm for designing UV NLO materials, with GUPO crystal emerging as a cheap, efficient alternative to conventional UV NLO crystals.}, archive = {J_ANGEW}, author = {Guangsheng Xu and Xue Bai and Zhihua Yang and Jian Han and Shilie Pan}, doi = {10.1002/anie.202510363}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510363}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π-conjugated cations in phosphates: A pathway to solar-blind UV nonlinear optical crystals with phase-matching}, volume = {64}, year = {2025}, }
• (2025). Catalytic 1,2-migratory insertion in a bismuth redox platform: Reductive arylation of aldehydes. ANGEW, 64(38), e202510360. (www)

  @article{ , abstract = {Herein, we report a catalytic defluorinative arylation of aldehydes with (per) A fluoroarenes facilitated by a pincer-based PheBox-Bi(I) under mild conditions. The protocol features various novel aspects in bismuth redox catalysis; namely, (1) a catalytic 1,2-aryl migratory insertion to forge a C─C bond, (2) an unprecedented example of multicomponent reaction through four elementary organometallic steps at a Bi center, (3) an unusual strategy for Bi(I) compounds regeneration via O─Si reductive elimination. Experimental and computational studies aided in dissecting the various mechanistic aspects of the bismuth redox cycle.}, archive = {J_ANGEW}, author = {Xiangrong Liu and Hye Won Moon and Davide Spinnato and Markus Leutzsch and Josep Cornella}, doi = {10.1002/anie.202510360}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510360}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic 1,2-migratory insertion in a bismuth redox platform: Reductive arylation of aldehydes}, volume = {64}, year = {2025}, }
• (2025). A weakly-solvating propylene carbonate electrolyte for high-voltage and low-temperature lithium-ion batteries. ANGEW, 64(38), e202510351. (www)

  @article{ , abstract = {Next-generation lithium-ion batteries (LIBs) require electrolytes compatible with high-voltage (>4.3 V) and low-temperature (<−10 °C) operation, yet commercial ethylene carbonate (EC)-based systems remain constrained by intrinsic limitations including poor oxidation stability at cathode side and high melting points. Although propylene carbonate (PC) demonstrates superior oxidative stability and lower melting temperature than EC, its tendency to cointercalate with Li + within the graphite anode interlayers restricts its applicability in LIBs. We propose a PC-based weakly-solvating electrolyte engineered with difluoroethylene carbonate (DFEC) that resolves interfacial challenges at both electrodes. The PC solvent facilitates oxidative resistance through formation of an inorganic-dominated cathode–electrolyte interphase (CEI), effectively mitigating transition metal dissolution at 4.4 V operation. Simultaneously, DFEC disrupts Li + -PC coordination through reduced solvent molecule numbers in the solvation shell, enabling generation of a stable solid electrolyte interphase (SEI) on graphite anodes with minimized interfacial impedance. Implemented in 5 Ah pouch cells, this electrolyte demonstrates 76.7% capacity retention after 2000 cycles (2.8–4.4 V) at room temperature (RT) and maintains 91% of its RT capacity at −20 °C, surpassing conventional EC-based electrolytes. This work presents an electrolyte engineering approach that synergistically addresses high-voltage durability and low-temperature functionality, providing a scalable solution for advanced LIB technologies.}, archive = {J_ANGEW}, author = {Chaonan Wang and Shaoyun Zhou and Zetai Xu and Jiaxuan She and Qiang Xiao and Rong Huang and Yi Cui and Yuhao Lu and Hongchang Jin and Hengxing Ji}, doi = {10.1002/anie.202510351}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510351}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A weakly-solvating propylene carbonate electrolyte for high-voltage and low-temperature lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Metallic ni as electron acceptor modulates the redox of catalytic centers at activated Ni0/Ni(OH)2 heterojunctions for efficient ethanol electrooxidation. ANGEW, 64(38), e202510285. (www)

  @article{ , abstract = {The coproduction of high-value-added acetate and hydrogen fuel by ethanol-assisted water electrolysis is significant, but the efficiency of ethanol electrooxidation (EOR) is hindered both by sluggish kinetics, primarily dictated by the redox properties of the catalyst. Therefore, the development of efficient EOR electrocatalysts has to target optimized redox properties. Herein, a Ni 0 /Ni(OH) 2 heterostructure was synthesized by inducing a shift from hydrophilic to hydrophobic properties on the electrode surface during electrochemical deposition. The electrocatalyst enabled a current density of 573.7 mA cm −2 at 1.37 V versus RHE for EOR with a solar-to-hydrogen conversion efficiency of 14.4% when coupled to a commercial solar panel. Experimental and theoretical results disclosed that the incorporation of Ni 0 facilitates the ethanol to acetate kinetics through enhanced Ni 2+ to Ni 3+ conversion. The strategy, combining hydrogen production with the synthesis of value-added products, enhances economic viability compared to conventional water electrolysis, underscoring its promise for practical implementation.}, archive = {J_ANGEW}, author = {Ruixing Du and Bin Wu and Weiling Tan and Yuchen Lei and Yunchuan Tu and Chalachew Mebrahtu and Zuohuan Chen and Shulong Li and Zuhui Zhou and Zhenchen Tang and Huanhao Chen and Shiming Chen and Long Chen and Jian-Jun Wang and Xiaofeng Shi and Yifan Ye and Dingsheng Wang and Regina Palkovits and Wei Zhao and Feng Zeng}, doi = {10.1002/anie.202510285}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510285}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metallic ni as electron acceptor modulates the redox of catalytic centers at activated Ni0/Ni(OH)2 heterojunctions for efficient ethanol electrooxidation}, volume = {64}, year = {2025}, }
• (2025). Hydrophobic poly(divinylbenzene) polymer-supported ruthenium catalysts for efficient hydrogenation of pyridines in water. ANGEW, 64(38), e202510284. (www)

  @article{ , abstract = {Gas–liquid–solid triphase reactions are limited by poor gas solubility and mass transfer, especially in water. The low solubility of hydrogen in water severely hinders the hydrogenation, therefore requiring high temperature and pressure to increase the activity, which have safety and cost concerns. Herein, we report a hydrophobic poly(divinylbenzene) polymer-supported Ru nanoparticle catalyst (Ru/PDVB) with both high activity and excellent stability for the hydrogenation of pyridines in water, even at ambient hydrogen pressure (0.1 MPa). The average turnover frequency (ATOF) of the Ru/PDVB (836.8 mol mol Ru −1 h −1 ) is about 6.0 and 768.0-fold higher than those of traditional Ru/C and commercial Raney Ni catalysts under equivalent reaction conditions. Mechanistic studies reveal that the hydrophobic polymer prevents filling of water in the nanopores of PDVB, allowing hydrogen enrichment to boost the hydrogenation. This work provides an opportunity to improve the efficiency of industrially important reactions that suffer from poor gas solubility and mass transfer.}, archive = {J_ANGEW}, author = {Qingsong Luo and Hai Wang and Yating Lv and Jinghao Fan and Huixin Wu and Wei Fang and Lujie Liu and Pei Liu and Liang Wang and Feng-Shou Xiao}, doi = {10.1002/anie.202510284}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510284}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrophobic poly(divinylbenzene) polymer-supported ruthenium catalysts for efficient hydrogenation of pyridines in water}, volume = {64}, year = {2025}, }
• (2025). Poly(p-phenylene phosphaborene): A modified poly(p-phenylene vinylene) with π-conjugated B═P linkages. ANGEW, 64(38), e202510272. (www)

  @article{ , abstract = {While the isoelectronic substitution of selected C═C by B═N units in π-conjugated organic compounds has evolved into a well-established concept to create novel hybrid materials with modified properties, the use of valence isoelectronic B═P units for such purposes has been hardly explored. Herein, we demonstrate substitutional doping of the famous optoelectronic organic polymer poly( p -phenylene vinylene) (PPV) with B═P linking groups for the first time. We report on the successful synthesis of a soluble polymer and a series of monodisperse oligomers of BP-PPV type. Our structural and photophysical investigations, supported by in-depth DFT calculations, evidence effective π-conjugation along their backbone, which is similary pronounced as in their previously reported BN congeners. In addition, the novel BCP compounds show distinct fluorescence emission in solution and emission enhancement upon aggregation (AIEE), occurring from a P-pyramidalized excited state.}, archive = {J_ANGEW}, author = {Julian Glock and Jonas Klopf and Merian Crumbach and Johannes Chorbacher and Johannes S. Schneider and Alexandra Friedrich and Emilia Buchsteiner and Tobias Bischof and Maik Finze and Bernd Engels and Holger Helten}, doi = {10.1002/anie.202510272}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510272}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Poly(p-phenylene phosphaborene): A modified poly(p-phenylene vinylene) with π-conjugated B═P linkages}, volume = {64}, year = {2025}, }
• (2025). Radical borylation of alkyl bromides by photoinduced halogen-atom transfer. ANGEW, 64(38), e202510162. (www)

  @article{ , abstract = {Alkyl organoboron compounds are versatile synthons in organic synthesis, enabling rapid access to a variety of carbon─carbon and carbon-heteroatom bonds. As such, strategies to efficiently access carbon-boron bonds from simple chemical feedstocks are highly desirable. The radical borylation of alkyl bromides presents an attractive approach. However, the activation of alkyl bromides typically requires strong reductants or transition-metal catalysts. Herein, we report a metal-free radical borylation strategy of various alkyl bromides utilizing a photoinduced silyl radical to mediate a halogen-atom transfer process. This method demonstrates broad utility and functional group tolerance among various primary, secondary, and tertiary unactivated alkyl bromides and can facilitate the functionalization of pharmaceutically relevant motifs. Mechanistic and computational studies support a radical-chain pathway involving a silyl radical-mediated halogen-atom transfer.}, archive = {J_ANGEW}, author = {Cullen R. Schull and Matthew J. McGill and Ángel Renteria-Gómez and Poulami Mukherjee and Samuel B. Tyndall and Aaron H. Shoemaker and Michael R. Wasielewski and Osvaldo Gutierrez and Karl A. Scheidt}, doi = {10.1002/anie.202510162}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radical borylation of alkyl bromides by photoinduced halogen-atom transfer}, volume = {64}, year = {2025}, }
• (2025). Distance-dependence of photo-CIDNP in biomimetic Tryptophan–Flavin diads. ANGEW, 64(38), e202510116. (www)

  @article{ , abstract = {Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are essential tools in natural and life sciences, but their low sensitivity often hampers their applicability. Photochemically induced dynamic nuclear polarization (photo-CIDNP) offers a versatile and mild method to overcome this limitation. Here, we report on structure-photo-CIDNP relationship studies in liquid-state NMR utilizing a holistic approach. We synthesized biomimetic tryptophan–flavin diads with varying linker lengths composed of conformationally rigid oligoproline units. The predominant polyproline II (PPII) helical structure ensures consistent donor–acceptor distances. Photo-CIDNP NMR experiments revealed significant hyperpolarization effects, particularly in diads with six proline units, mimicking the spatial arrangement found in natural photoactive proteins. Our findings highlight the potential of these biomimetic diads to enhance nuclear hyperpolarization in NMR spectroscopy. This work provides valuable insights into the design of diads for efficient photo-CIDNP generation, paving the way for advanced studies in modern NMR and bio-MRI.}, archive = {J_ANGEW}, author = {Tobias Theiss and Guzel Musabirova and Luca Gerhards and Irina S. Anisimova and Ben G. E. Zoller and Thi Ngoc Ha Nguyen and Dmitry Denisov and Anton Schmidt and Sabrina Panter and Stefan Weber and Christoph Tegenkamp and Ilia A. Solov'yov and Jörg Matysik and Tanja Gulder}, doi = {10.1002/anie.202510116}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202510116}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Distance-dependence of photo-CIDNP in biomimetic Tryptophan–Flavin diads}, volume = {64}, year = {2025}, }
• (2025). Sub-nano ir-based alloy clusters by hierarchical confinement effect for water splitting. ANGEW, 64(38), e202509993. (www)

  @article{ , abstract = {The synthesis of sub-nanoscale noble metal catalysts is pivotal for enhancing electrocatalytic performance, yet achieving precise control over particle size at this scale remains a critical challenge. In this work, we propose a hierarchical confinement strategy which combines spatial confinement at nanoscale and anchoring confinement at atomic scale, to overcome the size limitations imposed by high-temperature sintering. Using this strategy, a series of uniformly sized (∼1 nm) Ir-based alloy clusters, including IrMn, IrFe, IrCo and IrNi, are successfully fabricated. The synthesized sub-nanoscale IrCo alloy clusters (denoted as sub-IrCo cluster) demonstrate exceptional oxygen evolution reaction (OER) catalytic performance, with an ultralow overpotential of 210 mV at 10 mA cm - 2 and a remarkable mass activity 87.5 times greater than that of commercial IrO 2 . Density functional theory (DFT) and molecular dynamics (MD) simulations reveal that the incorporation of N enhances the interaction between Ir atoms and the support. This work provides an effective strategy for preventing particle sintering via a hierarchical confinement effect and achieves precise size control at sub-nanoscale, opening a new avenue for the development of efficient noble metal catalysts with high atomic utilization.}, archive = {J_ANGEW}, author = {Xuemin Cao and Han Cheng and Renjie Gui and Huijuan Zhang and Caijie Su and Chen Chen and Yifan Yin and Yi Tan and Huijuan Wang and Wangsheng Chu and Yue Lin and Gongming Wang and Yi Xie and Changzheng Wu}, doi = {10.1002/anie.202509993}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509993}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sub-nano ir-based alloy clusters by hierarchical confinement effect for water splitting}, volume = {64}, year = {2025}, }
• (2025). Electrolyte-controlled regiodivergent continuous flow electroselenocyclisations. ANGEW, 64(38), e202509811. (www)

  @article{ , abstract = {Supporting electrolytes, beyond traditionally serving as ionic conductors in electrochemistry, can influence regioselectivity in electrochemical synthesis by acting as base. We present a single-pass continuous flow electrolysis method enabling selective activation of diselenides and oximes to access seleno-substituted isoquinoline and isoindole derivatives. Mechanistic studies showed a radical pathway via iminoxyl radicals to isoindole N -oxides and an ionic mechanism leading to isoquinoline N -oxides. This process leverages N -activated neutral isoquinolinium products for diverse downstream modifications. Our findings highlight the untapped potential of supporting electrolytes in regiodivergent electrochemical transformations and provide a sustainable and scalable platform for continuous flow approaches for synthesising selenium-containing heterocycles with biological relevance.}, archive = {J_ANGEW}, author = {Sagar Arepally and Hanaa Gieman and Thomas Wirth}, doi = {10.1002/anie.202509811}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte-controlled regiodivergent continuous flow electroselenocyclisations}, volume = {64}, year = {2025}, }
• (2025). Exo-selective intramolecular (4+3) cycloadditions to trans-fused perhydroazulenes: An asymmetric formal synthesis of (−)-pseudolaric acid b. ANGEW, 64(38), e202509650. (www)

  @article{ , abstract = {We present an asymmetric formal total synthesis of pseudolaric acid B (PAB), based on the intramolecular (4+3) cycloaddition of a new class of epoxy enolsilane substrates. This substrate type has the epoxide geminally-substituted on the tether to the furan, which reacts to yield the trans -fused perhydroazulene core of PAB containing the quaternary stereocenter. The reaction is highly diastereoselective, as opposed to cycloadditions of previous substrate types that generate the perhydroazulene framework. The role of the geminal tether in controlling the transition state conformation and the exo -selectivity is revealed by density functional theory calculations. Using this intramolecular cycloaddition as the key reaction, together with several one-pot sequences, a key intermediate in Trost's synthesis of PAB was accomplished, representing the shortest asymmetric synthesis of this anti-tumor natural product thus far.}, archive = {J_ANGEW}, author = {Zengsheng Yin and Yuxuan He and Guo Wei and Yuchen Zhou and Antonio Rizzo and Yun He and Elizabeth H. Krenske and Pauline Chiu}, doi = {10.1002/anie.202509650}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509650}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exo-selective intramolecular (4+3) cycloadditions to trans-fused perhydroazulenes: An asymmetric formal synthesis of (−)-pseudolaric acid b}, volume = {64}, year = {2025}, }
• (2025). Central dynamic conversion of dicyanomethyl radicals via intermolecular charge transfer for ultrabright NIR-II fluorescence imaging-guided mild photothermal therapy. ANGEW, 64(38), e202509609. (www)

  @article{ , abstract = {Stable organic radicals have emerged as promising candidates in biotheranostics owing to their unique electronic configurations and tunable photophysical characteristics. Among these, dicyanomethyl radical derivatives stand out as key players in dynamic covalent chemistry, demonstrating exceptional temperature-responsive reversible polymerization-dissociation dynamics and remarkable long-wavelength absorption profiles despite their low molecular weights. In this work, we developed a novel radical system designated CNPJ through the strategic incorporation of julolidine into a dicyanomethyl-functionalized phenoxazine scaffold. The stability and radical nature of CNPJ were first corroborated by nucleus-independent chemical shift (NICS) calculations. Structural analyses revealed two critical phenomena enabled by efficient spin delocalization and intermolecular charge transfer: i) polarity-triggered radical center redistribution and ii) thermally regulated monomer‒π dimer equilibrium. These distinctive features confer enhanced structural rigidity and an exceptional absolute photoluminescence quantum yield of 2.57%, a remarkably high value for near-infrared emitters, accompanied by a bathochromically shifted π dimer absorption band centered at 960 nm. Capitalizing on these attributes, we engineered a theranostic platform by integrating CNPJ with the pH-responsive amphiphilic polymer PEA through pifithrin-μ (PES) inhibitor mediation. This system achieves ultrahigh-brightness fluorescence imaging-guided mild photothermal tumor therapy, yielding promising therapeutic outcomes.}, archive = {J_ANGEW}, author = {Yixuan Xu and Dalong Yin and Yating Wang and Dejia Chen and Xin Li and Lifeng Yan}, doi = {10.1002/anie.202509609}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509609}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Central dynamic conversion of dicyanomethyl radicals via intermolecular charge transfer for ultrabright NIR-II fluorescence imaging-guided mild photothermal therapy}, volume = {64}, year = {2025}, }
• (2025). Activation of a secondary-messenger receptor via allosteric modulation of a dynamic conformational ensemble. ANGEW, 64(38), e202509394. (www)

  @article{ , abstract = {Bacterial signaling cascades have recently become of great relevance in the context of bacterial antibiotics resistance. Cyclic diadenylate monophosphate (c-di-AMP) is a key bacterial secondary messenger involved in growth, biofilm formation, virulence gene expression and others. The activation mechanisms of c-di-AMP receptors like the trimeric P II -like proteins upon messenger binding have, however, remained elusive due the pivotal role of highly flexible protein regions. Here, using solution NMR spectroscopy to elucidate the interplay between the ordered and disordered structural elements of the apo and messenger-bound forms of the 44 kDa homotrimeric P II -like signal transduction protein A (PstA), we reveal a sensitive modulation of the conformational ensemble of those extended loops thought to bind the downstream interaction partners by messenger association at the receptor core. The orchestration of the spatial properties of the loops, despite their retained internal dynamics, reveals the importance of allosteric effects even for disordered structural elements, whose steerable ensemble properties have long escaped the classical structural-biology understanding.}, archive = {J_ANGEW}, author = {Benedikt Söldner and Himanshu Singh and Elias Akoury and Gregor Witte and Rasmus Linser}, doi = {10.1002/anie.202509394}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509394}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activation of a secondary-messenger receptor via allosteric modulation of a dynamic conformational ensemble}, volume = {64}, year = {2025}, }
• (2025). In-situ electrochemical reconstruction of copper single-sites to dual-sites for ambient urea synthesis. ANGEW, 64(38), e202509385. (www)

  @article{ , abstract = {Understanding and uncovering really catalytic active-sites during electrocatalysis is vital for carbon–nitrogen coupling reaction to synthesize urea. Here, we report a Copper (Cu) single-atom catalyst (Cu-N 3 SAs) with a Cu–N 3 coordination structure for the electrochemical coreduction of CO 2 and NO 3 − into urea. The in situ X-ray absorption spectroscopy (XAS) reveals that the Cu–N 3 configured single-sites undergo electrochemically structural reconstruction to form N 2 –Cu–Cu–N 2 dual-sites in Cu–N 3 SAs, exhibiting efficient urea synthesis performance. The in-situ spectroscopy combined with mass spectrometry confirms that the initial C–N coupling reaction involves the formation of *CONH from *CO and *NH intermediates generated via the coreduction of CO 2 and NO 3 − on the N 2 –Cu–Cu–N 2 dual-sites. The in-situ electrochemical formed Cu dual-sites not only enhance the adsorption of *CO, but also facilitates the multi-electron transfer processes with lowered energy barrier for the formation of *CONH intermediates.}, archive = {J_ANGEW}, author = {Jiafang Liu and Shengbo Zhang and Zhixian Mao and Wenyi Li and Meng Jin and Huajie Yin and Yunxia Zhang and Guozhong Wang and Haimin Zhang and Huijun Zhao}, doi = {10.1002/anie.202509385}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509385}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-situ electrochemical reconstruction of copper single-sites to dual-sites for ambient urea synthesis}, volume = {64}, year = {2025}, }
• (2025). Redox-switchable poly-lewis acids allow the controlled release of guests. ANGEW, 64(38), e202509191. (www)

  @article{ , abstract = {Presently, there is a notable interest in poly-Lewis acids (PLAs), their host-guest chemistry and their application in catalytic processes. The present study combines PLAs with redox-active dibenzo[ a , e ]cyclooctatetraene (dbCOT) units. dbCOT-based PLAs can be planarised by a two-electron reduction. The molecular structures of the reduced PLAs, studied by sc-XRD experiments and DFT calculations, show the formation of extended -systems. This -system extends to the Lewis acid functions and reduces their acidity. This allows a controlled release of complexed guest molecules. Oxidation regenerates the original Lewis acidity. Such reduction/oxidation cycles were also applied to an Al─P coordination polymer. sc-XRD shows the connectivity of the coordination polymer to remain unchanged, so that the polymer is stable in the neutral and reduced state. The possibility of switching such dbCOT-based PLAs and their adducts as well as the formed coordination polymers between two states with different structures and electronic compositions is of interest for the development of functional materials in the fields of electronics, optics and magnetism as well as for the development of switchable catalysts.}, archive = {J_ANGEW}, author = {Maximilian J. Klingsiek and Yury V. Vishnevskiy and Julian Buth and Jan-Hendrik Lamm and Beate Neumann and Hans-Georg Stammler and Norbert W. Mitzel}, doi = {10.1002/anie.202509191}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-switchable poly-lewis acids allow the controlled release of guests}, volume = {64}, year = {2025}, }
• (2025). Evolving data-driven strategies for the characterization of supramolecular polymers and systems. ANGEW, 64(38), e202509122. (www)

  @article{ , abstract = {Inspired by the dynamic assembly of fibrillar proteins in biology, research on supramolecular polymers has progressed rapidly toward the development of synthetic multicomponent systems. In this review, we highlight recent advances in the study of supramolecular polymers in solution, with an emphasis on how combined computational and experimental approaches deepen our understanding of these systems. In particular, these studies have elucidated the mechanisms of protein aggregation and provided insights into the characteristics of synthetic systems. We discuss the classification of these polymers and systems, highlighting how their different interaction modes and microstructures give rise to diverse structural and functional properties. In addition, we outline the emerging role of machine learning as a powerful tool to navigate the inherent complexity of these systems, thereby enhancing strategies for rational design and characterization. This review highlights how computational approaches, from traditional modeling to emerging machine learning techniques, enable the experimental characterization and understanding of supramolecular polymer chemistry.}, archive = {J_ANGEW}, author = {Stef A. H. Jansen and Ghislaine Vantomme and E. W. Meijer}, doi = {10.1002/anie.202509122}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509122}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evolving data-driven strategies for the characterization of supramolecular polymers and systems}, volume = {64}, year = {2025}, }
• (2025). Unbiased stable photoelectrochemical glycerol oxidation on hematite photoanodes. ANGEW, 64(38), e202509062. (www)

  @article{ , abstract = {Photoelectrochemical glycerol oxidation reaction (PEC GOR) is considered as one of the promising strategies for obtaining high-value products and transforming solar energy to hydrogen. Herein, we report that a Ge/Zr co-doped Fe 2 O 3 photoanode present an excellent and stable PEC performance for glycerol oxidation to formate (FA) product. The Ge and Zr co-doping synergistically reduce charge carrier recombination and enhance charge transfer kinetics of the photoanode, promoting the selectivity and Faradaic efficiency toward FA chemical. Further the deposition of NiFeB co-catalyst promotes the cleavage of C─C bonds in glycerol molecules while inhibiting oxygen evolution reaction and facilitating FA accumulation. Impressively, the unbiased PEC tandem configuration for glycerol oxidation was established for coupling NiFeB/Ge/Zr-Fe 2 O 3 photoanode with Fe(Pt)-NC cathode, achieving a photocurrent density of ∼1.9 mA cm −2 with continuously operation of 100 h. The bias-free device maintains FA selectivity of above 80% with an accumulation of 1683 µmol cm −2 , representing the best PEC GOR performance toward high-value chemicals reported so far. The reaction mechanism was clarified through in situ characterization. This work provides new avenues for the sustainable solar-powered chemical synthesis of unbiased PEC systems with high selectivity and durability.}, archive = {J_ANGEW}, author = {Kerong Su and Hengyi Chen and Shijie Ren and Rui-Ting Gao and Limin Wu and Lei Wang}, doi = {10.1002/anie.202509062}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202509062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unbiased stable photoelectrochemical glycerol oxidation on hematite photoanodes}, volume = {64}, year = {2025}, }
• (2025). Achieving charge-transfer-featured organic room-temperature phosphorescence with combined high efficiency and long lifetime via V-shaped D–A dyads. ANGEW, 64(38), e202508776. (www)

  @article{ , abstract = {The realization of long-lived charge-transfer-based organic room-temperature phosphorescence ( 3 CT-RTP, τ Ph = 210 ms) via the construction of U-shaped donor–acceptor (D–A) dyads is impeded by suboptimal phosphorescence efficiency ( = 6%). Herein, we reveal that modifying the skeleton of D–A dyads from U-shaped to V-shaped configurations yields 3 CT-RTP with both long τ Ph (150–220 ms) and high (13%–25%). This improvement stems from preserving a substantial degree of forbiddenness in the radiative transition process of the compound while simultaneously increasing its D–A dihedral angle, which can promote more efficient spin-orbit coupling and thus more rapid intersystem crossing. Additionally, augmenting the framework rigidity of a V-shaped D–A dyad can potentially reduce the non-radiative transition rate constant of triplet excitons ( k nr,T ), thereby facilitating the attainment of long τ Ph and high .}, archive = {J_ANGEW}, author = {Kuan Chen and Binhao Li and Chuanhao Liu and Yanju Luo and Kaixin Yu and Mengjiao Jia and Yan Huang and Zhiyun Lu}, doi = {10.1002/anie.202508776}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving charge-transfer-featured organic room-temperature phosphorescence with combined high efficiency and long lifetime via V-shaped D–A dyads}, volume = {64}, year = {2025}, }
• (2025). Distinct charge transport and its regulation in single-molecule and monolayer junctions. ANGEW, 64(38), e202508708. (www)

  @article{ , abstract = {As electronic devices miniaturize to the nanometer scale, molecular junctions, including single and monolayer molecules, are gaining attention for applications in logic, storage, and sensing. However, comparative studies of charge transport in these two junction types are limited. Here, a highly conjugated pyrene derivative has been engineered to construct both single-molecule and monolayer junctions. The charge transport within these junctions has been examined systematically through theoretical simulations and electrical measurements. These studies demonstrate a distinct transition in a single molecule from temperature-independent coherent tunneling to temperature-dependent incoherent transport, indicating vibration-mediated transport, while vibration-suppressed coherent transport is observed in a densely packed monolayer. Additionally, anisotropic gating experiments reveal that parallel fields relative to the molecular connection modulate energy levels more efficiently in comparison with perpendicular fields. These findings enrich our understanding of molecular electronic transport and pave the way for diverse developments in the field of molecular electronic devices.}, archive = {J_ANGEW}, author = {Lan Yang and Cong Zhao and Ju Wang and Feifan Yue and Zhehao He and Mingliang Li and Guangwu Li and Jinying Wang and Chuancheng Jia and Xuefeng Guo}, doi = {10.1002/anie.202508708}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508708}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Distinct charge transport and its regulation in single-molecule and monolayer junctions}, volume = {64}, year = {2025}, }
• (2025). Unsaturated phosphine oxides for modular antibody rebridging and single reagent peptide-cyclization-bioconjugation. ANGEW, 64(38), e202508656. (www)

  @article{ , abstract = {Achieving modular, selective and homogeneous protein modifications is of utmost importance for the design of next generation biopharmaceuticals, especially in the context of antibody-drug conjugates (ADCs). Here, we introduce unsaturated phosphine oxides as versatile triple-reactive reagents, allowing orthogonal chemoselective bioconjugation schemes. Starting from triethynyl-phosphine oxide, a variety of functionalized diethynyl-triazolyl-phosphine oxides (DTPOs) could be accessed by using Cu I -catalyzed azide-alkyne cycloaddition (CuAAC). We showcase DTPO-reagents in the fast and selective generation of various highly stable antibody-conjugates via antibody disulfide rebridging. A highlight from this methodology is the synthesis of a DAR 4 ADC following a modular 2-step strategy using bioorthogonal tetrazine-labeling with bicyclo-[6.1.0]non-4-yne (BCN) or trans -cyclooctene (TCO) containing payloads. Notably, the DTPO-rebridged ADC exhibited potent cytotoxicity against Her2 + cancer cells. Moreover, we utilize triethynyl-phosphine oxide to obtain ethynyl-ditriazolyl-phosphine oxides (EDPOs) which enable a unique, single-reagent peptide-cyclization-bioconjugation protocol resulting in functional cyclic peptide-protein conjugates. Overall, our work provides versatile and powerful chemoselective modalities for the controlled modification of antibodies, peptide-cyclization and peptide-protein conjugation, expanding the toolkit for chemical biology and therapeutic development.}, archive = {J_ANGEW}, author = {Christian E. Stieger and Alastair J. McMillan and Mark A. R. de Geus and Jan Vincent V. Arafiles and Luise Franz and Christian P. R. Hackenberger}, doi = {10.1002/anie.202508656}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508656}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unsaturated phosphine oxides for modular antibody rebridging and single reagent peptide-cyclization-bioconjugation}, volume = {64}, year = {2025}, }
• (2025). Molecular rotor-based NIR-II TICTgens for mitochondria-targeted pyroptosis induction and multi-model monitoring of cancer immunotherapy. ANGEW, 64(38), e202508646. (www)

  @article{ , abstract = {Pyroptosis has emerged as a promising mechanism for eliciting robust antitumor immunity; however, the current pyroptosis inducers lack tumor-selectivity and feedback of therapeutic effect. In this study, we developed a series of twisted intramolecular charge transfer luminogens (TICTgens) for precisely regulating and in situ monitoring of tumor cell pyroptosis in vitro and in vivo. The outperformed TICTgen HCM displayed second near-infrared (NIR-II) fluorescence emission and exceptional viscosity sensitivity. Upon 671 nm laser irradiation, HCM induced the generation of type-I/II reactive oxygen species (ROS) and hyperthermia effect, which cumulatively triggered mitochondrial damage and pyroptosis of tumor cells. HCM was systemically delivered via intracellular acidity-sensitive nanoparticles (namely PDPA@HCM NPs) to effectively trigger pyroptosis-driven antitumor immunity. Notably, HCM performed NIR-II fluorescence and photoacoustic (PA) imaging of pyroptosis-induced mitochondrial dysfunction by measuring viscosity change, thus enabling in situ monitoring of pyroptosis-mediated antitumor immunotherapy. In combination with immune checkpoint blockade therapy, the PDPA@HCM NPs dramatically regressed colorectal tumor growth in a mouse model. Overall, this study demonstrated that the TICTgens could serve as a versatile platform for pyroptosis induction and monitoring of pyroptosis-based cancer immunotherapy.}, archive = {J_ANGEW}, author = {Min Li and Jing Gao and Yaxiong Xie and Zifan Zhu and Lujia Huang and Yi Lai and Muhammad Yar and Marek Bajda and Ming Li and Haijun Yu and Feng Wang and Zhiai Xu}, doi = {10.1002/anie.202508646}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508646}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular rotor-based NIR-II TICTgens for mitochondria-targeted pyroptosis induction and multi-model monitoring of cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Expanding the repertoire of photoswitchable unnatural amino acids for enzyme engineering. ANGEW, 64(38), e202508562. (www)

  @article{ , abstract = {Photoswitchable unnatural amino acids (psUAAs) play a crucial role in the engineering of light-sensitivity in enzymes, which holds significant promise for diverse applications such as biotherapy and biocatalysis. Besides near-quantitative photoconversion, the success and expediency of a psUAA for a certain application is defined by its interaction potential with the enzyme, its thermal stability and its effective wavelength of irradiation. To establish high versatility in the current repertoire, we have designed and synthesized six psUAAs based on azobenzene, arylazopyrazole, arylazothiazole, hemithioindigo and spiropyran photoswitches. The resulting psUAAs exhibit an enhanced interaction potential within an enzyme owing to their capacity for hydrogen bonding, ionic interactions and metal ion coordination. Moreover, we observed diverse photochemical behaviors among the psUAAs, with four of them reversibly switching between the isomers with purely visible light. Notably, we identified orthogonal aminoacyl-tRNA synthetases that facilitate the incorporation of five of the six psUAAs co-translationally and computationally analyzed the synthetase-psUAA interactions. Finally, we evaluated the photochemical behavior of the five psUAAs within an enzymatic model and tested the photocontrol of catalysis confirming their diversity. Ultimately, our findings significantly expanded the repertoire of psUAAs and demonstrated their feasibility for enzyme engineering studies.}, archive = {J_ANGEW}, author = {Caroline Hiefinger and Michela Marcon and Verena Pape and Guillem Casadevall and Ranit Lahmy and Christoph Haag and Julian Nazet and Michael Bartl and Astrid Bruckmann and Sílvia Osuna and Burkhard König and Andrea Hupfeld}, doi = {10.1002/anie.202508562}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508562}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expanding the repertoire of photoswitchable unnatural amino acids for enzyme engineering}, volume = {64}, year = {2025}, }
• (2025). Multi-color switchable luminescence in organic-inorganic metal halides via local polyhedron regulation under light and temperature stimuli. ANGEW, 64(38), e202508487. (www)

  @article{ , abstract = {Organic-inorganic metal halides (OIMHs) with multi-color switchable luminescence have raised pervasive attention in the field of sensing, optoelectronics, anti-counterfeiting, information encryption and storage. However, the complexity of soft lattice structures makes it difficult to establish design rules for realizing the luminescence regulation, which greatly hinders their practical applications. Herein, a series of 0D OIMHs are designed, including PA 3 SbCl 6 , PA 6 InCl 9 , PMA 4 InCl 7 , PEA 2 InCl 5 ·H 2 O and PPA 4 InCl 7 . Tunable self-trapped excitons (STEs) emission from 606 to 678 nm originated from [SbCl n ] 3-n are realized in these 0D structures by Sb 3+ doping at room temperature. The correlations among structural distortion, bandgap, emission position, and quantum yield are investigated in these 0D Sb 3+ -doped OIMHs. The greater distortion of local inorganic polyhedron induces a relative red-shift emission, while the increased separation distance between local inorganic polyhedron reduces non-radiative transitions, therefore enhancing quantum yield. Moreover, multi-emission centers are constructed in Sb 3+ /Bi 3+ -doped PMA 4 InCl 7 , achieving green/red and blue/green/red tunable multi-color switching luminescence under the regulation of excitation wavelength and temperature. Based on the multi-color luminescence response characteristics, potential application demonstrations in optical anti-counterfeiting and information encryption are designed. This suggests the application potential of constructing multi-color switchable luminescence in OIMHs using ns 2 ions, providing a new design perspective for low-dimensional OIMHs.}, archive = {J_ANGEW}, author = {Wei Yang and Peipei Dang and Dongjie Liu and Yingsheng Wang and Long Tian and Yi Wei and Hongzhou Lian and Guogang Li and Jun Lin}, doi = {10.1002/anie.202508487}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508487}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-color switchable luminescence in organic-inorganic metal halides via local polyhedron regulation under light and temperature stimuli}, volume = {64}, year = {2025}, }
• (2025). Chirality makes or breaks chemically driven self-assembly. ANGEW, 64(38), e202508481. (www)

  @article{ , abstract = {Nature has consistently selected homochiral building blocks from millions of possible diastereomers across diverse biomolecular structures to drive molecular recognition, catalysis and self-assembly. Despite its central role in biology, chirality's influence on chemically driven reaction networks remains unexplored. Here, we demonstrate that chiral aminoacyl phosphate esters, synthetic analogs of biological acylating intermediates, drive self-assembly and reaction pathways, that are modulated purely by their configuration, without the need for changes in functional groups. Using enantiopure aminoacyl phosphate esters, we show that these left- and right-handed acylating agents generate transient epimeric (thio)-esters from homochiral peptide substrates, leading to supramolecular architectures with distinct lifetimes and self-assembly dynamics. Moreover, chirality regulates downstream reactivity in cascade reactions, where stereochemical control over an intermediate propagates into subsequent transformations. Finally, chiral acylating agents differentiate between two reaction cycles, selectively modulating one pathway while keeping another invariant – a level of control that remains difficult to achieve with conventional chemical strategies. Stereochemical programming enables control over reactivity and self-assembly, offering new opportunities to encode chirality in reaction networks and modulate their function through a single molecular parameter.}, archive = {J_ANGEW}, author = {Lenard Saile and Kun Dai and Mahesh D. Pol and Thejus Pramod and Ralf Thomann and Charalampos G. Pappas}, doi = {10.1002/anie.202508481}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508481}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chirality makes or breaks chemically driven self-assembly}, volume = {64}, year = {2025}, }
• (2025). AI-driven discovery and molecular engineering design for enhancing interface stability of black phosphorus. ANGEW, 64(38), e202508454. (www)

  @article{ , abstract = {Molecular engineering offers significant potential for developing advanced interfacial materials, yet the complexity of organic molecules poses challenges in discovering optimal structures. This study leveraged large language model (LLM) and machine learning (ML) to accelerate molecular discovery and guide molecular engineering for enhancing the stability of black phosphorus (BP), a promising 2D semiconductor but rapidly degrades when exposed to oxygen and moisture. By utilizing GPT-4o, molecular groups such as ─SiR 3 , ─PR 2 , ─SH, and ═NH that interact effectively with BP were identified and a high-throughput workflow employing graph neural networks (GNNs) models was developed to successfully predict and screen 662 promising candidates from over 117 million molecules. These candidates were validated by density functional theory (DFT) simulations and experiments, with synthesis protocols guided by GPT-4o, achieving great interfacial stabilization of BP for up to 24 days under ambient conditions. Furthermore, a new synergistic molecular engineering strategy was proposed by incorporating functional head, linker, and tail groups of molecules to even enable the use of hydrophilic molecules to stabilize BP surface, overcoming traditional design limitations. This work highlights the AI technologies not only in optimizing BP interfacial stability but also in broader aspects of molecular engineering for various materials.}, archive = {J_ANGEW}, author = {Chao Peng and Bing Wang and Lie Wu and Haoqu Jin and Yutang Li and Wenxia Gao and Jie Zhou and Guolai Jiang and Chen Wang and Jiahong Wang and Xingchen He and Denis Kramer and Paul K. Chu and Xue-Feng Yu}, doi = {10.1002/anie.202508454}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508454}, shortjournal = {Angew. Chem. Int. Edit.}, title = {AI-driven discovery and molecular engineering design for enhancing interface stability of black phosphorus}, volume = {64}, year = {2025}, }
• (2025). Rational design of CDK12/13 and BRD4 molecular glue degraders. ANGEW, 64(38), e202508427. (www)

  @article{ , abstract = {Targeted protein degradation (TPD) is an emerging therapeutic approach for the selective elimination of disease-related proteins. While molecular glue degraders exhibit drug-like properties, their discovery has traditionally been serendipitous and often requires post hoc rationalization. In this study, we demonstrate the rational, mechanism-guided design of molecular glue degraders using gluing moieties. Building on established principles, by appending a chemical gluing moiety to several small molecule inhibitors, we successfully transformed them into degraders, obviating the need for a specific E3 ubiquitin ligase recruiter. Specifically, we found that incorporating a hydrophobic aromatic ring or a double bond into a cyclin-dependent kinase 12 and 13 (CDK12/13) dual inhibitor enabled the recruitment of DNA damage-binding protein 1 (DDB1), thereby transforming a high-molecular-weight bivalent CDK12 degrader into a potent monovalent CDK12/13 molecular glue degrader. We also showcase that attaching a cysteine-reactive warhead to a bromodomain-containing protein 4 (BRD4) inhibitor converts it into a degrader by recruiting the DDB1 and CUL4-associated factor 16 (DCAF16) E3 ligase.}, archive = {J_ANGEW}, author = {Zhe Zhuang and Woong Sub Byun and Zuzanna Kozicka and Katherine A. Donovan and Brendan G. Dwyer and Abby M. Thornhill and Hannah M. Jones and Zixuan Jiang and Xijun Zhu and Eric S. Fischer and Nicolas H. Thomä and Nathanael S. Gray}, doi = {10.1002/anie.202508427}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508427}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design of CDK12/13 and BRD4 molecular glue degraders}, volume = {64}, year = {2025}, }
• (2025). Coordinating the competitive adsorption of organic and OH− to accelerate electrooxidation kinetics of biomass-derived nucleophiles. ANGEW, 64(38), e202508095. (www)

  @article{ , abstract = {Elaborating electrooxidation mechanisms of biomass molecules on transition-metal-based electrodes is crucial to designing high-performance active sites. Herein, we unveiled the direct oxidation mechanism of three electrode models, Co 4 N, CoO, and Co 4 N–CoO, in which the adsorptions of OH − and glycerol on the electrodes were competitive. The adsorption of glycerol on Co 4 N was quite strong but weak on CoO, whereas the CoO preferred to adsorb OH − species. The one-sided adsorption properties of surface reactants led to the sluggish electrooxidation kinetics of organics on Co 4 N and CoO. Constructing Co 4 N–CoO heterointerfaces significantly balanced the one-sided adsorption features. Due to the moderate OH − and glycerol adsorptions on Co 4 N–CoO, the OH − was mainly used to activate glycerol rather than trigger the oxidative reconstruction of materials to form high-valence OER sites. Consequently, the Co 4 N–CoO showed excellent glycerol oxidation properties. The Co 4 N–CoO delivered a lower Tafel slope of 178 mV dec −1 while achieving a high formate yield rate of 29.40 mmol cm −2 h −1 . Furthermore, the Faradaic efficiency (FE) of formate was maintained above 90% in a 120-h electrolysis. In situ Raman and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) experiments and DFT simulations unraveled that the improved GOR performance was mainly ascribed to the balanced co-adsorptions of OH − and organics on Co 4 N–CoO interfaces.}, archive = {J_ANGEW}, author = {Baojun Long and Mingyu Yang and Yuchan Li and Wenqing Li and Dong He and Zunjian Ke and Xiangheng Xiao}, doi = {10.1002/anie.202508095}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202508095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coordinating the competitive adsorption of organic and OH− to accelerate electrooxidation kinetics of biomass-derived nucleophiles}, volume = {64}, year = {2025}, }
• (2025). Engineering cavity and aperture binding sites within a Metal–Organic cage for up- and down-regulation of catalysis. ANGEW, 64(38), e202507981. (www)

  @article{ , abstract = {Engineering molecular recognition events into catalytic systems to precisely control the up- or down-regulation of catalysis in a biomimetic fashion is a challenging goal in supramolecular chemistry. In this work, we report on the construction of a new metal–organic cage, Zn II 4 L 4 tetrahedron 1 , using a protonated azacalix[3](2,6)pyridine-based ligand as the capping faces. The cage features a large cavity and wide gaps between its faces, enabling the simultaneous binding of anionic guests centrally and peripherally. Encapsulation of α-Mo 8 O 26 4− within the T -symmetric tetrahedron 1 leads to a C 3 -symmetric inclusion complex Mo 8 O 26 4− ⊂ 1 . The apertures of Mo 8 O 26 4− ⊂ 1 act as secondary binding sites for accommodating tetraarylborate guests or for providing access to the included Mo 8 O 26 4− for catalyzing reactions. Catalytic experiments demonstrated that inclusion within 1 significantly enhances the catalytic activity of Mo 8 O 26 4− for the oxidation of sulfides into sulfoxides. In contrast, peripheral binding of the bulky tetraarylborate anion to the inclusion complex Mo 8 O 26 4− ⊂ 1 effectively inhibits its catalytic activity by obstructing access to the catalytic active sites of Mo 8 O 26 4− .}, archive = {J_ANGEW}, author = {Yan Xu and Gen Li and Shihang Liang and Gaël De Leener and Michel Luhmer and Roy Lavendomme and En-Qing Gao and Dawei Zhang}, doi = {10.1002/anie.202507981}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202507981}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering cavity and aperture binding sites within a Metal–Organic cage for up- and down-regulation of catalysis}, volume = {64}, year = {2025}, }
• (2025). Bright long-wavelength multi-state TADF emitters. ANGEW, 64(38), e202507793. (www)

  @article{ , abstract = {To achieve multi-state, visible-light-excited, long-wavelength thermally activated delayed fluorescence (TADF) with high emission efficiency within a single molecular dye system remains a significant challenge. Herein, we developed a series of V-shaped emitters comprising electron-deficient benzothiadiazole and electron-rich triphenylamine (TPA) or carbazole (Cz) units, featuring small singlet-triplet energy gaps. These molecules exhibit long-wavelength TADF emission and bright luminescence in both single-molecule and aggregate states. The V-shaped structure prompts multiple intramolecular hydrogen bonds, while the intramolecular charge transfer effect significantly relaxes the molecular conformation in the excited state. These synergistic effects result in a rigid excited-state molecular conformation, facilitating strong single-molecule state emission with a high luminescence efficiency up to 75.90% (delayed: 26.57%). Meanwhile, the unique V-shaped structure and long alkyl chains enable these luminophores to maintain a twisted conformation and staggered stacking in the aggregate state, effectively preventing aggregation-caused quenching effects. Furthermore, the regular crystal environment ensures that these molecules possess a bright aggregate-state TADF luminescence with a high quantum yield up to 53.50% (delayed: 11.23%). Benefiting from their excellent photophysical properties, these molecules were successfully applied as functional dyes for concentration-independent cell imaging and antibacterial treatment. This work paves the way for designing long-wavelength TADF materials with efficient multi-state emission.}, archive = {J_ANGEW}, author = {Xueru Shan and Xiuqin Lu and Smruti Ranjan Sahoo and Yingying Hu and Glib V. Baryshnikov and Hans Ågren and Jian Jin and Cheng Qian and Fengkun Chen and Hongwei Wu}, doi = {10.1002/anie.202507793}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202507793}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bright long-wavelength multi-state TADF emitters}, volume = {64}, year = {2025}, }
• (2025). Strain energy prompted tunable aggregation-induced emission property of tetraphenylethylene. ANGEW, 64(38), e202507763. (www)

  @article{ , abstract = {Organic molecules exhibiting aggregation-induced emission (AIE) have attracted considerable attention due to their exceptional solid-state luminescent properties. Understanding the AIE mechanism has been a focal point of both theoretical and experimental research. While conical intersection (CI) dynamics on potential energy surfaces (PESs) have emerged as a key factor in elucidating the AIE mechanism, modulating the accessibility to CI to regulate the non-radiative decay pathways remains a substantial challenge. Here we propose a new strategy leveraging strain energy introduced by cycloparaphenylenes (CPPs) to tune the AIE property of tetraphenylethylene (TPE). We synthesized and characterized a series of TPE-incorporated CPPs with varying sizes and endo / exo vinyl moieties. The photophysical properties and AIE behavior of these strained TPE-CPPs were meticulously examined. Endo -TPE-CPPs exhibit AIE, while Exo -TPE-CPPs do not, opposite to strain-free TPE macrocycles. The luminescence of Endo -TPE-CPPs and Exo -TPE-CPPs can be further tuned by adjusting the number of phenylene units in the loop. Their excited-state dynamics were investigated using density functional theory (DFT) calculation and time-resolved absorption spectroscopy. The strain energy induces structural distortion of TPE, stabilizing or elevating the transition state (TS), thereby regulating the accessibility to CI and enabling tunable AIE properties. These findings provide new insights for designing AIE molecules.}, archive = {J_ANGEW}, author = {Kai Lan and Cefei Zhang and Yifei Li and Changwei Hu and Zhishan Su and Chuyang Cheng}, doi = {10.1002/anie.202507763}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202507763}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strain energy prompted tunable aggregation-induced emission property of tetraphenylethylene}, volume = {64}, year = {2025}, }
• (2025). Well-defined redox-active hyperbranched polymers for flow batteries: Harnessing self-condensing vinyl copolymerization by flow chemistry. ANGEW, 64(38), e202507739. (www)

  @article{ , abstract = {The increased adoption of renewable power necessitates the development of grid-scale storage solutions, with aqueous redox flow batteries (RFBs) at the forefront. Despite their potential, performance limitations arising from high solution viscosity at high concentrations of active material and rapid degradation due to active material crossover continue to pose challenges. Here, we use flow chemistry to create redox-active hyperbranched copolymers (HBCs), which exhibited substantially improved suppression of crossover and enhanced rheology behaviors. The distinct reaction dynamics of flow chemistry facilitated the efficient and monomer-independent control over self-condensing vinyl polymerization, yielding well-defined HBCs with remarkably low dispersity. This strategy effectively enhanced the uniformity of the redox-active HBCs, leading to significantly reduced crossover and accelerated diffusion rates. The RFBs equipped with our redox-active HBCs exhibited long-term stability, mapping a pathway towards practical application of polymer-based technologies as well as highlighting the unique advantages of the flow chemistry techniques in high-precision electrolyte design.}, archive = {J_ANGEW}, author = {Yi Lv and Yuqing Zhang and Feichen Cui and Yipeng Zhang and Zixiao Wang and Junlong Yang and Qinzhe Liu and Yingshuai Zhao and Yijun Zheng and Chao Xu and Jiajun Yan}, doi = {10.1002/anie.202507739}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202507739}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Well-defined redox-active hyperbranched polymers for flow batteries: Harnessing self-condensing vinyl copolymerization by flow chemistry}, volume = {64}, year = {2025}, }
• (2025). Quantum chemistry calculation-assisted large-scale collision cross section prediction empowers derivatization-enhanced multidimensional metabolomics. ANGEW, 64(38), e202507483. (www)

  @article{ , abstract = {Derivatization-enhanced multidimensional metabolomics combined with ion mobility mass spectrometry will greatly improve the accuracy and coverage of metabolic analysis. However, accurate prediction of the large-scale collision cross section (CCS) of derivatized metabolites without relying on standards and the establishment of multidimensional analytical methods faces great challenges. Here, we propose quantum chemistry calculation-assisted machine learning strategies applicable to the accurate prediction of the CCS of derivatized sterols, develop C═C bond-targeted N-Me derivatization methods for unsaturated sterols, and create a large-scale, 4D information database of derivatized sterol lipids ( n = 4891) by combining retention time and fragment ion prediction. Furthermore, a high-coverage unsaturated sterolomics at the isomer level was established on this basis, which quantitatively revealed the tissue-specific distribution patterns of over 100 sterol lipids. This study provides a key foundation for derivatization-enhanced metabolomics and provides important techniques and information for metabolic and functional studies of sterols.}, archive = {J_ANGEW}, author = {Jian Sun and Junmeng Luo and Ming Gao and Fang Wang and Wenjing Nie and Moran Chen and Suming Chen}, doi = {10.1002/anie.202507483}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202507483}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantum chemistry calculation-assisted large-scale collision cross section prediction empowers derivatization-enhanced multidimensional metabolomics}, volume = {64}, year = {2025}, }
• (2025). Ligand-controlled chromium catalysis for tunable Z/E selectivity in asymmetric homoallylic alcohol synthesis. ANGEW, 64(38), e202507474. (www)

  @article{ , abstract = {Chiral homoallylic alcohols with vicinal stereocenters and well-defined Z/E alkene geometries are key structural motifs in bioactive polyketides, yet their efficient and selective synthesis remains a long-standing challenge in asymmetric catalysis. Existing strategies often require preformed organometallic reagents or separate catalytic systems to access different alkene geometries, limiting synthetic efficiency and versatility. Herein, we report a chromium-catalyzed asymmetric reductive coupling of allyl gem -dichlorides with aldehydes, enabling precise and tunable control over regio-, enantio-, diastereo-, and Z/E -selectivity. This radical-polar crossover strategy circumvents the need for preformed organometallic reagents, offering a direct and modular approach to stereochemically complex homoallylic alcohols. A chiral imidazoline sulfonamide ligand directs the formation of Z -alkenes, while a bisoxazoline ligand reverses the selectivity to E -alkenes, achieving excellent stereocontrol across a broad substrate scope. Mechanistic studies support a chromium-mediated allyl radical generation and addition pathway. This work establishes a versatile platform for constructing stereochemically defined homoallylic alcohols and expands the synthetic utility of allyl gem -dichlorides in asymmetric catalysis.}, archive = {J_ANGEW}, author = {Xiaowen Xia and Tianbing Yao and Zhaoxin Shi and Zhaobin Wang}, doi = {10.1002/anie.202507474}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202507474}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-controlled chromium catalysis for tunable Z/E selectivity in asymmetric homoallylic alcohol synthesis}, volume = {64}, year = {2025}, }
• (2025). Elucidating ligand exchange dynamics of hexacyanochromate-based redox mediators in aqueous iron-chromium redox flow batteries. ANGEW, 64(38), e202507119. (www)

  @article{ , abstract = {Aqueous redox flow batteries (AQRFBs) are revolutionizing energy storage by integrating sustainability with cutting-edge innovation. Among them, Iron-Chromium RFBs (Fe-Cr RFBs), which utilize aqueous-based electrolytes, effectively address critical challenges in renewable energy integration while offering unparalleled safety, low-cost scalability and environmental compatibility. Potassium hexacyanochromate (K 3 [Cr(CN) 6 ]) has emerged as a promising negolyte material in Fe-Cr RFBs due to its favorable electrochemical properties. However, enhancing its long-term stability and elucidating its structural transformations remain crucial for optimized performance. Investigations into ligand exchange mechanism reveal connections to detrimental side reactions, notably hydrogen evolution reaction (HER) and hexacyanochromate instability, highlighting pathways for targeted improvement. Density functional theory (DFT) calculations illuminate the effects of ligand exchange dynamics and structural variations on redox stability, providing mechanistic insights into electrolyte behavior. By strategically incorporating sodium hydroxide with sodium cyanide as supporting electrolytes, our study demonstrates significantly improved stability of the redox couple, achieving a stable cycling performance over 250 cycles with an energy density of 13.91 Wh L −1 and energy efficiencies exceeding 76%–77%. This research provides valuable insights into the degradation pathways of hexacyanochromate-based negolyte and emphasizes the importance of optimized electrolyte design for advancing sustainable energy storage technologies.}, archive = {J_ANGEW}, author = {Ji-Eun Jang and Vithiya Muralidharan and Yoon Seong Kim and Hyunwoo Kim and Jungki Ryu and Guihua Yu and Dong-Hwa Seo and Hyun-Wook Lee}, doi = {10.1002/anie.202507119}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202507119}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elucidating ligand exchange dynamics of hexacyanochromate-based redox mediators in aqueous iron-chromium redox flow batteries}, volume = {64}, year = {2025}, }
• (2025). Electrochemical polymerization of 1,2-dithiolane derivatives at room temperature. ANGEW, 64(38), e202506724. (www)

  @article{ , abstract = {Recently, 1,2-dithiolanes derived polydisulfides have prompted growing research interests. An innovative polymerization method with convenient operation under mild conditions is needed for improving monomer conversion, polymerization degree, and bulk performance. Here, we report an electrochemically initiated ring-opening polymerization (ROP) of thioctic acid (TA) monomers and its derivatives at room temperature, with high monomer conversion and polymerization degree. The resulting polymer exhibits potential as a transparent and vibration-damping coating. Electrochemical oxidation was the key step for initiating the rapidly polymerization and could completely circumvent the use of chemical initiators or harsh conditions. Cyclic voltammetry experiments identified the oxidation of TA at anode accompanying with an absorption-controlled one-electron transfer process. Together with density functional theory calculations, we proposed a cationic radical-initiated polymerization process. This unique electrochemical polymerization strategy was simple, rapid, efficient, and applicable for diverse TA-derived monomers.}, archive = {J_ANGEW}, author = {Jun Fang and Chenhao Ji and Yanshan Meng and Pengyuan Ye and Houyu Zhang and Wen Li}, doi = {10.1002/anie.202506724}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202506724}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical polymerization of 1,2-dithiolane derivatives at room temperature}, volume = {64}, year = {2025}, }
• (2025). Ensemble of active acid sites on amorphous Silica–Alumina surfaces for catalytic cracking. ANGEW, 64(38), e202506711. (www)

  @article{ , abstract = {Amorphous silica–alumina are critical materials in catalysis, particularly for fluid catalytic cracking (FCC). However, the atomic scale understanding of the active sites has been challenging, because of the nonuniform atomic distribution and the material's amorphous nature. Here, we use density functional theory (DFT), machine learning potentials and sampling methods to investigate the relationship between structure and acidity in silica-modified alumina. Under FCC conditions, we predict an ensemble of acid sites with diverse local structures and a spectrum of acid strengths, including zeolite-like bridging Brønsted acid sites (BAS) and pseudo-bridging silanol BAS. This distribution is influenced by surface structure, Si coverage, and extent of hydroxylation, shaped by synthesis methods and reaction conditions. Experiments using a model Si-stabilized alumina catalyst confirm that Brønsted acidity increases with Si content, peaking at an optimal value before declining. These insights provide a foundation for designing efficient solid acid catalysts for industrial applications.}, archive = {J_ANGEW}, author = {Kaustubh J. Sawant and David Stockwell and Anthony Debellis and Lucas Dorazio and Philippe Sautet}, doi = {10.1002/anie.202506711}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202506711}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ensemble of active acid sites on amorphous Silica–Alumina surfaces for catalytic cracking}, volume = {64}, year = {2025}, }
• (2025). A chemically tailorable multifunctional protein platform for glutamatergic neuron targeting in mouse brain. ANGEW, 64(38), e202506692. (www)

  @article{ , abstract = {Targeting glutamatergic neurons is critical for understanding brain functions and treating neurological disorders linked to glutamate dysregulation. However, existing methods face challenges including low specificity, slow kinetics, poor blood-brain barrier (BBB) penetration, and reliance on transgenic pathways. Here, we report the cyanobacterial ferredoxin-dependent glutamate synthase (Fd-GOGAT cb ) as a non-transgenic, multifunctional platform for rapid and selective targeting of glutamatergic neurons in vivo. We demonstrate the high affinity of Fd-GOGAT cb to glutamatergic neuron membranes that allows for fixation-free labeling within 1–2 h, and its self-deliverable BBB-crossing capability via systemic administration in living mice. When conjugated with functional motifs (e.g., fluorophores or photosensitizers), Fd-GOGAT cb enables in vivo glutamatergic neuron-targeted imaging and neuromodulation, displaying region-specific enrichment in glutamate-dependent brain circuits and light-responsive neuron inhibition through intravenous delivery of photodynamic conjugates. This platform addresses longstanding barriers for direct neuron targeting and manipulation in vivo, proving its adaptability for versatile applications by chemical functionalization and potential transformative value in glutamate-centered fundamental research and clinical translation.}, archive = {J_ANGEW}, author = {Xiaoti Yang and Shuxin Li and Jing Liu and Lijuan Hou and Ran Liu and Xinjie Sun and Rui Yao and Ming Wang and Fei Wu and Ping Yu and Lanqun Mao}, doi = {10.1002/anie.202506692}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202506692}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A chemically tailorable multifunctional protein platform for glutamatergic neuron targeting in mouse brain}, volume = {64}, year = {2025}, }
• (2025). Molecular design of asymmetric difluorinated ether electrolytes for stable operation of high-voltage lithium metal batteries. ANGEW, 64(38), e202506056. (www)

  @article{ , abstract = {Fluorination of electrolyte solvents is key to improving the cycling stability of high-voltage lithium metal batteries (LMBs), yet the critical role of fluorinated alkyl chain length in governing solvation and interphase chemistries remains unclear. Herein, we systematically engineered a series of methoxy ethoxy methane derivatives with tailored fluorinated alkyl groups to screen the optimal asymmetric difluorinated electrolytes for high-voltage LMBs. Spectroscopic and computational studies show that the ─CF 2 H group in difluoroethoxy methoxy methane (DFME) facilitates balanced Li─F interactions, which are essential for ensuring efficient ion transport and maintaining oxidation stability. In contrast, the elongated ─CF 2 CF 2 H group in tetrafluoropropyl methoxy methane (TFME) fails to coordinate with Li + ions, which hampers ion transport and leads to interfacial instability. The DFME electrolyte facilitates the spontaneous formation of a protective dual-layer interface featuring a LiF-rich inner phase and a Li 2 CO 3 -dominated outer phase. Consequently, Li||LiCoO 2 cells (2.5 mAh cm −2 ) using DFME exhibit remarkable cycling stability, retaining 92% capacity after 180 cycles. This is further corroborated by a 140-mAh pouch cell, which retains 91% capacity after 140 cycles. Our study offers fundamental insights into the design of advanced fluorinated electrolytes for the stable operation of high-voltage LMBs.}, archive = {J_ANGEW}, author = {Guangzhao Zhang and Tong Zhang and Yuqi Liu and Qingrong Wang and Ruilin He and Pengxian Li and Yanming Cui and Zhongbo Liu and Chaoyang Wang and Yonghong Deng and Jian Chang and Jun Lu}, doi = {10.1002/anie.202506056}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202506056}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular design of asymmetric difluorinated ether electrolytes for stable operation of high-voltage lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Facet engineering and Fe─N─Co bridged heterojunction enable Fe3O4@C@ZIF67 as high-performance photocatalyst for ammonia synthesis. ANGEW, 64(38), e202505932. (www)

  @article{ , abstract = {Ammonia synthesis is vital for global fertilizer production but traditionally relies on the energy-intensive Haber–Bosch process, a major contributor to CO 2 emissions. Photocatalytic nitrogen reduction reaction (PNRR) offers a sustainable alternative by harnessing solar energy under ambient conditions. However, challenges such as low nitrogen adsorption, poor conductivity, and high electron-hole recombination of the photocatalysts limit their efficiency. This study introduces an Fe 3 O 4 @C@ZIF67 core-shell photocatalyst featuring an Fe─N─Co bridged Z-scheme heterojunction. This design incorporates carbon-coated Fe 3 O 4 in ZIF67-D (ZIF67-dodecahedron) with exposed (211) crystalline facets to enhance nitrogen adsorption. Fe─N 4 and Co─N 4 active sites improve catalytic activity, while the carbon layer enhances conductivity and facilitates oxygen vacancy formation. The Fe─N─Co bridged heterojunction further promotes charge separation and transfer. Therefore, the Fe 3 O 4 @C@ZIF67 composite achieves an outstanding ammonia yield of 33.2 mmol L −1 g −1 h −1 (outperforming other systems) with high selectivity and minimal by-products. This work provides valuable insights into the design of high-performance photocatalysts by integrating the advantages of metal–organic frameworks, core-shell architectures, and interfacial engineering, marking a significant step forward in sustainable ammonia synthesis.}, archive = {J_ANGEW}, author = {Jingjing Wang and Liying Wang and Haibo Guo and Jing Ning and Zhenzhu Cao and Yongfeng Zhang and Lin Cheng and Ziwei Tong and Zhongchao Bai and Nana Wang}, doi = {10.1002/anie.202505932}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202505932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facet engineering and Fe─N─Co bridged heterojunction enable Fe3O4@C@ZIF67 as high-performance photocatalyst for ammonia synthesis}, volume = {64}, year = {2025}, }
• (2025). Synthesis of gold hydride at high pressure and high temperature. ANGEW, 64(38), e202505811. (www)

  @article{ , abstract = {Gold is an unreactive metal and its chemical interactions with hydrogen have only recently been explored. Here, we report the formation of gold hydride above 40 GPa and 2200 K in X-ray free electron laser heated diamond anvil cells using various hydrocarbons as hydrogen sources. Above 40 GPa, a hexagonal phase emerges close to the gold melting point, corresponding to a hydride with stoichiometry , with increasing from 0 to near 1 with pressure from 40 to 80 GPa. This is a high-temperature phase which reverts to face centered cubic gold on cooling to 295 K. Accompanying DFT-MD simulations are in excellent agreement with experiment and reveal the structure to consist of an hexagonal close packed gold lattice with atomic hydrogen disordered in the interstices. The hydrogen is superionic and exhibits high diffusivity through the crystalline gold lattice. Our results present the first solid-state binary compound of gold and hydrogen.}, archive = {J_ANGEW}, author = {Mungo Frost and Kilian Abraham and Alexander F. Goncharov and R. Stewart McWilliams and Rachel J. Husband and Michal Andrzejewski and Karen Appel and Carsten Baehtz and Armin Bergermann and Danielle Brown and Elena Bykova and Anna Celeste and Eric Edmund and Nicholas J. Hartley and Konstantin Glazyrin and Heinz Graafsma and Nicolas Jaisle and Zuzana Konôpková and Torsten Laurus and Yu Lin and Bernhard Massani and Maximilian Schörner and Maximilian Schulze and Cornelius Strohm and Minxue Tang and Zena Younes and Gerd Steinle-Neumann and Ronald Redmer and Siegfried H. Glenzer}, doi = {10.1002/anie.202505811}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202505811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of gold hydride at high pressure and high temperature}, volume = {64}, year = {2025}, }
• (2025). Leveraging electrons for electrochemical CO2 capture using a hemi-labile iron complex. ANGEW, 64(38), e202505723. (www)

  @article{ , abstract = {Climate change, driven by anthropogenic carbon emissions, demands urgent action to prevent a 2050 tipping point. With CO 2 levels at 427 ppm (50% above pre-industrial levels), deploying energy-efficient carbon capture technologies is crucial. Electrochemical carbon capture processes that have been touted to have the potential to meet these needs rely on the applied cell voltage, and electron utilization (CO 2 molecules separated per electron), which has generally been asserted to have a theoretical limit of one. Here, we introduce an electron-leveraging strategy to enhance electron utilization beyond this limit to 1.43 by employing Fe-EDDHA, a redox-active coordination complex having a ligand with multiple hemi-labile coordination sites. The reversibility and robustness of the system were enabled by the efficient prevention of CO 2 reduction upon the introduction of nicotinamide as a guardian of the iron(2+) center. The proof-of-concept cyclic system exhibits a minimum operational energy of 22.6 kJ e mol −1 and an average of 63.7 kJ e mol −1 over 29 cycles, using a simulated flue gas (15% CO 2 ). Our electron-leveraging strategy holds promise for advancing energy-efficient electrochemical carbon capture technologies, and offers an alternative to prevalent redox potential shifting methods proposed to mitigate undesired electron transfer reactions in redox-active materials across diverse operational conditions.}, archive = {J_ANGEW}, author = {Hyowon Seo and Ying Chen and Eric Walter and Maryam Abdinejad and T. Alan Hatton}, doi = {10.1002/anie.202505723}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202505723}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging electrons for electrochemical CO2 capture using a hemi-labile iron complex}, volume = {64}, year = {2025}, }
• (2025). Engineering mechanostable anticalin scaffolds to enhance particle adhesion and targeting of CTLA-4 under shear stress. ANGEW, 64(38), e202504483. (www)

  @article{ , abstract = {Achieving high binding strength and efficient delivery of molecular cargo to cells expressing biomarker targets is a significant challenge in drug delivery. Here, we investigated how altering the surface immobilization residue (i.e., anchor point) within a non-antibody binding scaffold called Anticalin can enhance particle adhesion to the immune checkpoint protein CTLA-4 on mammalian cells under shear stress. By introducing bio-orthogonal clickable amino acids into Anticalin at various positions and applying tension to the protein complex using single-molecule AFM force spectroscopy and bead-based adhesion assays, we elucidate the relationship between anchor point position and mechanostability of the Anticalin:(CTLA-4) complex. Multi-regression analysis of the physicochemical properties of the anchor points revealed that the distance from the anchor point on Anticalin to CTLA-4′s center of mass was a major determinant of binding strength under shear flow. These results demonstrate how anchor point engineering can enhance particle adhesion and cellular delivery to CTLA-4 targets and provide a heuristic for choosing surface immobilization points of targeting proteins such that they withstand high mechanical forces.}, archive = {J_ANGEW}, author = {Yang Sun and Jiajun Li and Rosario Vanella and Haipei Liu and Zhaowei Liu and Michael A. Nash}, doi = {10.1002/anie.202504483}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202504483}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering mechanostable anticalin scaffolds to enhance particle adhesion and targeting of CTLA-4 under shear stress}, volume = {64}, year = {2025}, }
• (2025). Efficient electronic-structure methods toward catalyst screening: Projection-based embedding theory for CO2 reduction reaction intermediates. ANGEW, 64(38), e202503418. (www)

  @article{ , abstract = {Catalyst screening is a demanding task for computational chemistry since the profound diversity of surface structures under operando conditions is accompanied by high demands on the accuracy to predict the relevant kinetics. Embedding approaches that allow researchers to focus the computational effort on the chemically active regions of interest are promising tools in the pursuit of balancing accuracy and efficiency. However, for metallic catalysts, the required separation of the system into an active part treated with highly accurate methods and an environment is technically hard to achieve due to the delocalization of electrons in the conducting surface. Therefore, studies analyzing the potential of embedding methods for heterogeneous (electro-)catalyst screening are scarce. In this contribution, we demonstrate that simple embedding approaches are indeed achievable for studying metallic catalysts if i) the active orbital space is held consistent over a reaction coordinate and ii) the nonadditive exchange-correlation functional used to calculate the embedding potential includes a fraction of exact exchange to mitigate delocalization errors. We verify the approach for a set of open- and closed-shell CO 2 reduction reaction intermediates on different adsorption sites of a Cu(111) surface represented by cluster models to demonstrate that catalyst screening with embedding approaches is achievable.}, archive = {J_ANGEW}, author = {Elena Kolodzeiski and Christopher J. Stein}, doi = {10.1002/anie.202503418}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202503418}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient electronic-structure methods toward catalyst screening: Projection-based embedding theory for CO2 reduction reaction intermediates}, volume = {64}, year = {2025}, }
• (2025). Bridging donor ligands enable an ultrastable graphite anode for sodium-ion batteries. ANGEW, 64(38), e202503027. (www)

  @article{ , abstract = {Graphite is widely utilized as an anode material in lithium-ion batteries due to its abundance, cost-effectiveness, and excellent structural stability during lithium intercalation and deintercalation, which contribute to a long cycle life. However, graphite is not inherently suitable for sodium-ion batteries (SIBs) due to the limited intercalation properties of sodium ions. To address this, we propose the concept of bridging-donor-ligands, which construct ligand channels and consistently expand the graphite interlayer spacing. Using sodium dicyandiamide (NaDCA) as a model ligand, we demonstrate the formation of abundant ligand channels facilitated by the versatile dicyanamide anion (DCA − ), significantly enhancing the structural robustness of ternary graphite intercalation compounds (t-GICs). Hence, the graphite anode capacity retention is over 94% after 5000 cycles, with an average Coulombic efficiency (CE) exceeding 99.8% in SIBs. This mechanism is versatile and can be extended to other metal-ion battery electrolytes.}, archive = {J_ANGEW}, author = {Bingyan Song and Zhifen Luo and Xi Liu and Yi Peng and Jie Wang and Feng Jiang and Xin-Bing Cheng and Yuping Wu and Jiarui He}, doi = {10.1002/anie.202503027}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202503027}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bridging donor ligands enable an ultrastable graphite anode for sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Photocatalyzed synthesis of unsymmetrical Alkylphosphorus(V) compounds using imidazolium phosphonites. ANGEW, 64(38), e202502803. (www)

  @article{ , abstract = {Here, we report a synthetic approach for a wide range of unsymmetrical alkylphosphorus(V) compounds, alkyl-P(O)XY (X ≠ Y) using imidazolium phosphonites as bifunctional reagents. This protocol consists of two sequences, C(sp 3 )─P bond formation via an organic photoredox-catalyzed decarboxylative alkylation of imidazolium phosphonites with aliphatic carboxylic acid derivatives and P─X (X═O, N, F, and S) bond formation via the S N P(V) reaction. In this process, the imidazolium group facilitates 1) radical addition to the phosphonite reagent by stabilizing the resulting phosphoranyl radical intermediate and 2) the S N P(V) reaction as a good leaving group. This protocol allows the introduction of primary , secondary and tertiary alkyl substituents and various heteroatom substituents onto P(V) scaffolds.}, archive = {J_ANGEW}, author = {Kenji Ota and Yuki Fujiwara and Kazunori Nagao and Hirohisa Ohmiya}, doi = {10.1002/anie.202502803}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202502803}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalyzed synthesis of unsymmetrical Alkylphosphorus(V) compounds using imidazolium phosphonites}, volume = {64}, year = {2025}, }
• (2025). Carbon-negative ammonia production from the air. ANGEW, 64(38), e202423934. (www)

  @article{ , abstract = {Ammonia holds paramount importance as a fundamental chemical commodity for large-scale production of fertilisers and hydrogen carriers. The conventional Haber–Bosch process relies heavily on fossil fuels, making ammonia synthesis a significant contributor to greenhouse gas emissions. Here, we show a carbon-negative ammonia synthesis process that not only produces ammonia from the air but also directly captures the atmospheric CO 2 (DAC). This process uses lithium as a mediator to cleave the nitrogen gas via a nitridation reaction at ambient pressure below 80 °C. Exposing the nitride to moisture naturally yields ammonia. The co-produced lithium hydroxide intermediate allows for spontaneous absorption of CO 2 with an exceptional capacity of 18.4 mmol CO 2 /g. The resultant lithium carbonate is electrolysed at ambient conditions to recycle the metallic lithium and release high-purity gaseous CO 2 . This proof-of-concept of ammonia production from air coupled with DAC paves a new way for the development of sustainable and negative-emission technologies.}, archive = {J_ANGEW}, author = {Dingqi Wang and Xue Yan and Jining Guo and Longbing Qu and Chao Wu and Jefferson Zhe Liu and Ali Zavabeti and Gang Kevin Li}, doi = {10.1002/anie.202423934}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {38}, pages = {e202423934}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon-negative ammonia production from the air}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Dual co sites in n─n type heterojunction enable selective electrochemical co-valorization of HMF and CO2. ANGEW, 64(37), e202583702. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583702}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202583702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Dual co sites in n─n type heterojunction enable selective electrochemical co-valorization of HMF and CO2}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Stable yet strongly lewis-acidic anions enabling cooperative catalysis with cationic transition-metal complexes. ANGEW, 64(37), e202583701. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583701}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202583701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Stable yet strongly lewis-acidic anions enabling cooperative catalysis with cationic transition-metal complexes}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Visual β-sheet-to-β-turn transition in luminescent polymeric vesicles for color-reporting drug delivery (Angew. chem. int. ed. 37/2025). ANGEW, 64(37), e202517894. (www)

  @article{ , archive = {J_ANGEW}, author = {Zifen Li and Yang Liu and Yiwei Wang and Yi Zheng and Chuan Peng and Zuojie Wang and Yeqiang Zhou and Xiaohan Dong and Mingming Ding}, doi = {10.1002/anie.202517894}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202517894}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Visual β-sheet-to-β-turn transition in luminescent polymeric vesicles for color-reporting drug delivery (Angew. chem. int. ed. 37/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Flexibility-aided orientational self-sorting and transformations of bioactive homochiral cuboctahedron Pd12L16 (Angew. chem. int. ed. 37/2025). ANGEW, 64(37), e202517790. (www)

  @article{ , archive = {J_ANGEW}, author = {Subhasis Chattopadhyay and Robin Durník and Anniina Kiesilä and Elina Kalenius and Juha M. Linnanto and Pavel Babica and Jan Kuta and Radek Marek and Ondřej Jurček}, doi = {10.1002/anie.202517790}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202517790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Flexibility-aided orientational self-sorting and transformations of bioactive homochiral cuboctahedron Pd12L16 (Angew. chem. int. ed. 37/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Hinge-like mechanochromic mechanophores based on [2.2]Paracyclophane (Angew. chem. int. ed. 37/2025). ANGEW, 64(37), e202517347. (www)

  @article{ , archive = {J_ANGEW}, author = {Shohei Shimizu and Jess M. Clough and Christoph Weder and Yoshimitsu Sagara}, doi = {10.1002/anie.202517347}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202517347}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Hinge-like mechanochromic mechanophores based on [2.2]Paracyclophane (Angew. chem. int. ed. 37/2025)}, volume = {64}, year = {2025}, }
• (2025). Lili lin. ANGEW, 64(37), e202516365. (www)

  @article{ , archive = {J_ANGEW}, author = {Lili Lin}, doi = {10.1002/anie.202516365}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202516365}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lili lin}, volume = {64}, year = {2025}, }
• (2025). Diogo alves gálico. ANGEW, 64(37), e202516338. (www)

  @article{ , archive = {J_ANGEW}, author = {Diogo Alves Gálico}, doi = {10.1002/anie.202516338}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202516338}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diogo alves gálico}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Logic-gated release of a dual payload from a β-lactam mechanophore with a rotaxane actuator (Angew. chem. int. ed. 37/2025). ANGEW, 64(37), e202516221. (www)

  @article{ , archive = {J_ANGEW}, author = {Lei Chen and Guillaume De Bo}, doi = {10.1002/anie.202516221}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202516221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Logic-gated release of a dual payload from a β-lactam mechanophore with a rotaxane actuator (Angew. chem. int. ed. 37/2025)}, volume = {64}, year = {2025}, }
• (2025). Flexibility-aided orientational self-sorting and transformations of bioactive homochiral cuboctahedron Pd12L16. ANGEW, 64(37), e202513902. (www)

  @article{ , abstract = {The rational design and selective self-assembly of flexible and unsymmetric ligands into large coordination complexes is an eminent challenge in supramolecular coordination chemistry. Here, we present the coordination-driven self-assembly of natural ursodeoxycholic-bile-acid-derived unsymmetric tris -pyridyl ligand ( L ) resulting in the selective and switchable formation of chiral stellated Pd 6 L 8 and Pd 12 L 16 cages. The selectivity of the cage originates in the adaptivity and flexibility of the arms of the ligand bearing pyridyl moieties. The interspecific transformations can be controlled by changes in the reaction conditions. The orientational self-sorting of L into a single constitutional isomer of each cage, i.e., homochiral quadruple and octuple right-handed helical species, was confirmed by a combination of molecular modelling and circular dichroism. The cages, derived from natural amphiphilic transport molecules, mediate the higher cellular uptake and increase the anticancer activity of bioactive palladium cations as determined in studies using in vitro 3D spheroids of the human hepatic cells HepG2.}, archive = {J_ANGEW}, author = {Subhasis Chattopadhyay and Robin Durník and Anniina Kiesilä and Elina Kalenius and Juha M. Linnanto and Pavel Babica and Jan Kuta and Radek Marek and Ondřej Jurček}, doi = {10.1002/anie.202513902}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202513902}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flexibility-aided orientational self-sorting and transformations of bioactive homochiral cuboctahedron Pd12L16}, volume = {64}, year = {2025}, }
• (2025). Photo-induced catalytic dearomative coupling of N-heteroarenes. ANGEW, 64(37), e202513552. (www)

  @article{ , abstract = {Naturally occurring dimeric products have attracted considerable attention from both chemists and pharmacologists. The construction of pseudo-dimers often requires elaborate synthetic effort with low efficiency. Dearomatization reactions represent an ideal method to transform planar aromatics into 3D skeletons, which has attracted increasing interest in medicinal chemistry and total synthesis. Herein, we present a dearomative dimerization of N -heteroarenes under mild photochemical conditions. Through additive regulation, the catalytic dearomative cross-coupling of two distinct quinolines could also be achieved. With aromatic compounds as coupling partners, this strategy provides a straightforward avenue to pseudo-dimers of N -heteroarenes. Combined experimental and computational mechanistic studies reveal the intertwined EnT/SET nature and offered guidelines for synthesizing novel bridged polycycles. In addition, this strategy provides an effective approach for constructing functional polymers with high atom economy and environmental benefits via metal-free, one-pot polymerization. Furthermore, the synthetic transformations offer a complementary route to access formal crossed products that were previously inaccessible.}, archive = {J_ANGEW}, author = {Fan Lin and Ting-Ting Song and Yan Liu and Xiao-Yu Wang and Shi-Yu Guo and Yaguang Sun and Qing-An Chen}, doi = {10.1002/anie.202513552}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202513552}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-induced catalytic dearomative coupling of N-heteroarenes}, volume = {64}, year = {2025}, }
• (2025). Ligand type guided keto-arylation enables modular total synthesis of polycyclic CBS xanthones. ANGEW, 64(37), e202513532. (www)

  @article{ , abstract = {The first total synthesis of the potent polycyclic xanthone antibiotics CBS72, CBS87 and CBS100 was accomplished by a modular strategy featuring a very demanding intermolecular aromatic keto-arylation. Central to the solution was a recently-developed ligand type approach, rather than brute force screening, demonstrating the usefulness of this novel concept in complex target synthesis. Additional key features include an asymmetric Davis hydroxylation proceeding with only catalytic amounts of base, thus enabling the conversion of a highly sensitive, elaborate substrate. Furthermore, a late-stage aminolysis completed the polycyclic framework, circumventing laborious protective group chemistry. Together, this strategy provides a concise, high-yielding access, confirming the full architecture of this most potent class of polyaromatic xanthones, and establishes ligand types as a powerful design tool for sophisticated cross-couplings.}, archive = {J_ANGEW}, author = {Jonas W. Meringdal and Vivienne Prangenberg and Tim Treiber and Andreas J. Schneider and Leon Honsdorf and Dirk Menche}, doi = {10.1002/anie.202513532}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202513532}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand type guided keto-arylation enables modular total synthesis of polycyclic CBS xanthones}, volume = {64}, year = {2025}, }
• (2025). Controlled crystallization kinetics via conjugated organic spacers enables ordered epitaxial growth of two-step deposited tin-based perovskite solar cells. ANGEW, 64(37), e202513416. (www)

  @article{ , abstract = {Tin-based perovskite films typically exhibit random crystal orientations, with significant accumulation of defects acting as charge recombination centers, which severely limit device performance. Furthermore, the disordered two-dimensional (2D) perovskite significantly impacts the subsequent crystal growth of three-dimensional (3D) perovskite through epitaxial growth mechanism, while the insulating properties of bulky spacer cations impede out-of-plane charge transport. Herein, we have innovatively developed a facile quasi-epitaxial growth strategy by introducing 2-(naphthalen-2-yl)ethanamine hydroiodide (NEAI) with reinforced π-conjugation interaction to construct orientationally aligned 2D perovskite, which acts as a template for 3D perovskite with (100)-dominant facet orientation. NEAI reacts with SnI 2 to pre-form NEA 2 SnI 4 , which subsequently converts to NEA 2 FASn 2 I 7 and ultimately FASnI 3 through an energetically unfavorable pathway to delay crystallization kinetics. Moreover, this innovative approach optimizes carrier transport dynamics while conferring device robust thermal degradation resistance and enhanced long-term stability. Consequently, the NEAI-based solar cells exhibit the impressive efficiencies of 14.03% (0.04 cm 2 ) and 12.44% (1 cm 2 ), representing the record performance for two-step deposited tin-based perovskite photovoltaics. This study offers new insights into the preparation of highly ordered tin-based perovskite films, paving the way for high-performance lead-free perovskite photovoltaics.}, archive = {J_ANGEW}, author = {Hongbo Zhou and Huan Rao and Yu Jin and Wenjian Zhu and Zeyang Deng and Yang Zhong and Wangping Sheng and Gengling Liu and Licheng Tan and Yiwang Chen}, doi = {10.1002/anie.202513416}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202513416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled crystallization kinetics via conjugated organic spacers enables ordered epitaxial growth of two-step deposited tin-based perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Scalable synthesis of stable hydrogen-bonded organic framework for efficient hexafluoroethane purification. ANGEW, 64(37), e202513398. (www)

  @article{ , abstract = {Developing stable, efficient and easily scalably-synthesized adsorbents for removal of hydrofluoroethanes to obtain high purity hexafluoroethane (C 2 F 6 ) is of great importance to the electronics industry. Herein, we report a hydrogen-bonded organic framework (HOF-TDBB) which exhibits statically as well as dynamically preferential hydrofluoroethanes (CF 3 CH 2 F and CF 3 CHF 2 ) adsorption and achieves efficient one-step C 2 F 6 purification from CF 3 CH 2 F/CF 3 CHF 2 /C 2 F 6 mixture. At 298 K, 11.7 mol kg −1 of high-purity C 2 F 6 can be obtained by HOF-TDBB from 5/5/90 CF 3 CH 2 F/CF 3 CHF 2 /C 2 F 6 mixture. Additionally, excellent stability endows HOF-TDBB with good separation ability under various harsh conditions. For example, the separation performance can be well maintained within the dozens of consecutive separation experiments. Even at 338 K, 5.7 mol kg −1 of pure C 2 F 6 can also be collected. More importantly, this material can be rapidly synthesized with a large scale by simple rotary evaporation. Combined with excellent separation performance, high stability and scalable synthesis, HOF-TDBB has unlocked its great potential in this challenging industrial separation.}, archive = {J_ANGEW}, author = {Zhenyu Ji and Yunzhe Zhou and Rajamani Krishna and Maochun Hong and Mingyan Wu}, doi = {10.1002/anie.202513398}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202513398}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable synthesis of stable hydrogen-bonded organic framework for efficient hexafluoroethane purification}, volume = {64}, year = {2025}, }
• (2025). Interfacial diffusion-reaction coupling strategy for CO2 reduction on copper surface in acidic medium. ANGEW, 64(37), e202513306. (www)

  @article{ , abstract = {CO 2 electroreduction reaction in acid medium to produce multicarbon (C 2+ ) products has gained attention as an alternative to the traditional processes in neutral or alkaline solutions which often suffer from low single-pass conversion efficiency due to (bi)carbonate accumulation at the cathode. However, the CO 2 conversion efficiency in acid remains unsatisfactory. Herein, a strong-polarized layer-covered Cu catalyst is developed as electrode for CO 2 reduction reaction (CO 2 RR) in acid. Such a strong dipole moment layer is a sp 3 -hybridized nitrogen ( sp 3 -N)-enriched azulene-based polymer, which acts as Lewis base to boost the CO 2 -diffusion kinetics in inner Helmholtz plane. Such unique electrode delivers nearly 84% C 2 Faradaic efficiency at 200 mA cm −2 , and demonstrates long-term stability over 40 h, which is the record for CO 2 RR in acidic media. In situ experiments manifest the moderate azulene-polarized sp 3 -N-enriched micro-environment can increase the local CO 2 /H 2 O ratio at electric double-layer to further stabilize the key intermediate atop-bound *CO. Theoretical calculations reveal that the strong-polarized layer decreases the reaction energy barrier for C–C coupling. This study not only uncovers the units with strong dipole moment on tuning sp 3 -N-enriched micro-environment, but also provides an interfacial diffusion-reaction coupling strategy to enhance the selectivity of CO 2 RR by decorating polycrystalline Cu with strong-polarized polymers.}, archive = {J_ANGEW}, author = {Xinyu Chai and Pengfei Shi and Jinyu Zhao and Senhe Huang and Kaiyue Jiang and Chenbao Lu and Liqing He and Jie Chen and Tianfu Wang and Xiaodong Zhuang}, doi = {10.1002/anie.202513306}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202513306}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial diffusion-reaction coupling strategy for CO2 reduction on copper surface in acidic medium}, volume = {64}, year = {2025}, }
• (2025). Functionalized Calix[4]Nanocones. ANGEW, 64(37), e202512873. (www)

  @article{ , abstract = {The interest in synthesizing conjugated nanobelts (CNBs) and nanocones has increased recently. Although a number of various structures have been achieved, almost none have additional functional groups at the peripheral rims. Based on a calix[4]arene, a functionalized calix[4]nanocone was synthesized. Due to its rigid structure in combination with methoxy groups on both the upper and the lower rim, the nanocone was tested for the binding of alkaline ions in solution by NMR measurements. The nanocone shows a high selectivity for binding Na + in favor of Li + and K + in CDCl 3 . By comparing the nanocone with a related but structurally flexible methoxy calix[4]arene, the impact of structural rigidity on selectivity is clearly demonstrated.}, archive = {J_ANGEW}, author = {Anika Haidisch and Frank Rominger and Michael Mastalerz}, doi = {10.1002/anie.202512873}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512873}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functionalized Calix[4]Nanocones}, volume = {64}, year = {2025}, }
• (2025). Recyclable side-chain azobenzene-based semicrystalline polymer films with outstanding intrinsic thermal conductivity and photoresponsive actuation. ANGEW, 64(37), e202512721. (www)

  @article{ , abstract = {Conventional polymers exhibit low intrinsic thermal conductivity ( λ ) of 0.1∼0.5 W/(m·K) due to disordered chain arrangements, failing to meet the heat dissipation demands of high-power flexible electronic devices. This study proposes a molecular level design strategy for side-chain azobenzene-containing semicrystalline polymers that demonstrate exceptional intrinsic thermal conductivity with photoresponsive actuation and recyclability. By precisely regulating the spatial distribution and content of azobenzene groups and hydrogen-bond network along the polymer chain through controlled radical polymerization, a thermal conduction network featuring “high-efficiency conduction within crystal domains and low-resistance interfacial connections” was constructed. Azobenzene moieties self-assemble into highly oriented crystalline domains through π–π stacking, where their dense packing significantly enhances phonon coupling efficiency and increases phonon mean free paths. Concurrently, the dynamic reversibility of hydrogen bonds guides domain-boundary molecular chains to form gradual phase transitions, suppressing phonon scattering at amorphous-crystalline interfaces and improving phonon transport efficiency. The film of random copolymer with 35 azobenzene units achieves an outstanding highest intrinsic λ of 2.01 W/(m·K), representing a substantial improvement over its block copolymer counterpart (with a higher crystallinity) and traditional polymers. Additionally, the photoisomerization property of azobenzene endows the material with light-controlled dynamic deformation capabilities. Meanwhile, the noncrosslinked polymer films feature easy recyclability/reprocessability.}, archive = {J_ANGEW}, author = {Qingqing Kong and Junliang Zhang and Kuan Zhang and Shuangshuang Wang and Mukun He and Yongqiang Guo and Junwei Gu}, doi = {10.1002/anie.202512721}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512721}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Recyclable side-chain azobenzene-based semicrystalline polymer films with outstanding intrinsic thermal conductivity and photoresponsive actuation}, volume = {64}, year = {2025}, }
• (2025). Logic-gated release of a dual payload from a β-lactam mechanophore with a rotaxane actuator. ANGEW, 64(37), e202512698. (www)

  @article{ , abstract = {The force-controlled release of functional molecules has attracted interest due to its potential use in drug delivery and self-healing applications. Clever mechanochemical devices have been developed to that effect, but most are limited by the payload (type, number) they can deliver and their responsiveness to a single stimulus (force). However, the applications envisaged above require the precise delivery of a complex payload. In this context, a device able to release a diverse set of cargo molecules in response to a varied number of stimuli is desired. Here, we present a rotaxane-based device that can release a dual payload in response to two different stimuli: force and water. The first payload is released mechanically, while the release of the second cargo requires both force and water in a way reminiscent of a logic AND gate. Our device is built around a β-lactam mechanophore that is activated by a rotaxane actuator to release a ketene and reveal an imine that anchors the second cargo to the axle of the rotaxane; hydrolysis of the imine releases the second cargo molecule. The concept was demonstrated with the efficient release of two drugs, hymecromone and gemcitabine, both in solution and in bulk. We anticipate that our device should find applications in a variety of contexts where precise release is required.}, archive = {J_ANGEW}, author = {Lei Chen and Guillaume De Bo}, doi = {10.1002/anie.202512698}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Logic-gated release of a dual payload from a β-lactam mechanophore with a rotaxane actuator}, volume = {64}, year = {2025}, }
• (2025). Monodisperse regulation of self-assembled monolayer via dipole molecules for efficient perovskite solar cells. ANGEW, 64(37), e202512660. (www)

  @article{ , abstract = {The application of self-assembled monolayers (SAMs) significantly drives the enhancement in the efficiency of perovskite solar cell (PSC). However, the transition mechanism of SAM molecules from colloidal solutions to films remains unclear. Herein, we systematically investigate the SAM precursor solutions and the crystallization quality of the resulting SAM and perovskite films. Fibrous micelles of about 460 nm are found in the pristine SAMs solution, leading to nonuniform and low coverage distribution of films. Strong dipole molecules are employed to establish supramolecular interactions with SAMs, enabling the formation of highly monodisperse cubic micelles in solution (160 nm) and uniform SAM films. The contact at buried interface is determined by the balance between dipole moment and steric hindrance. Consequently, the regulated SAMs based inverted PSCs (0.09 cm 2 ) and mini-module (aperture area of 14.40 cm 2 ) achieves efficiency of 26.58% (certificated 25.81%) and 22.95%, respectively. The optimized devices retain more than 96.30% of the initial efficiency for 5,100 h under the ISOS-D-1 condition with a linear fitting extrapolation to T 90 of 11,259 h and 98.30% efficiency for 2,660 h under the ISOS-L-2 condition. This work highlights the great potential of SAMs micelle regulation for achieving efficient and stable PSC.}, archive = {J_ANGEW}, author = {Zhinan Zhang and Yinghao Xu and Sifan Chen and Wenbo Li and Shaofu Wang and Chuan Peng and Shengjie Du and Sixiong Li and Xingzhong Zhao and Ti Wang and Zhenhua Yu}, doi = {10.1002/anie.202512660}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512660}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Monodisperse regulation of self-assembled monolayer via dipole molecules for efficient perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Electrochemical alkyl displacement of thioethers for streamlined trideuteromethylation. ANGEW, 64(37), e202512612. (www)

  @article{ , abstract = {Deuterated compounds exhibit significant pharmacokinetic advantages and have been widely applied in drug discovery. Trideuteromethyl-containing compounds represent a substantial portion of both approved deuterated drugs and those in development. Traditional approaches to incorporate trideuterated methyl group with trideuterated methyl sources (such as iodomethane- d 3 , dimethyl sulfate- d 6 ) require preactivated synthetic precursor, limiting the application for the late-stage trideuteromethyl group incorporation of pharmaceutical molecules. Herein, we develop an electrochemical approach for late-stage trideuteromethyl incorporation of thioether by using stoichiometric methanol- d 4 as the trideuteromethyl isotopic source via a sulfide alkyl displacement. This protocol features operational simplicity, selectivity, and scalability, enabling direct alkyl modification of various aryl alkyl sulfides as well as gram-scale production of trideuteromethyl drugs without the need for synthetic precursors. Mechanistic studies show that the in-situ generated sulfonium salt was the key intermediate. A series of control experiments reveals that alkanes as the departing moiety are the key to alkyl displacement and precise late-stage trideuteration.}, archive = {J_ANGEW}, author = {Hongshuai Chen and Yanghao Yin and Guoqing Wang and Xiao Xiao and Xuefeng Jiang and Minghao Feng}, doi = {10.1002/anie.202512612}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512612}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical alkyl displacement of thioethers for streamlined trideuteromethylation}, volume = {64}, year = {2025}, }
• (2025). General base-free suzuki-miyaura cross-coupling reaction via electrophilic substitution transmetalation. ANGEW, 64(37), e202512496. (www)

  @article{ , abstract = {The transition-metal-catalyzed Suzuki-Miyaura cross-coupling (SMC) reaction of organoboron nucleophiles with aryl (pseudo)halide electrophiles is a reliable method for carbon-carbon bond formation. This reaction generally requires the use of an exogenous base to promote transmetalation process, which limits the substrate scope of the reaction due to undesired protodeboronation and functional group incompatibilities. Here, we established a base-free SMC reaction via a conceptually different electrophilic substitution transmetalation (EST). This transformation is applicable to a wide range of base-sensitive and sterically hindered organoborons. Key to this advance is the formation of a stable cationic palladium(II) or nickel(II) intermediate via experimental and theoretical investigations. In a broader context, this research further expands the synthetic boundary of cross-coupling chemistry.}, archive = {J_ANGEW}, author = {Meng Zhang and Jing-Ran Shan and Yuke Xie and Lanen Wei and Haigen Xiong and Ge-Ning Xie and Ting Qi and Qinqin Shi and K. N. Houk and Hui Huang}, doi = {10.1002/anie.202512496}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {General base-free suzuki-miyaura cross-coupling reaction via electrophilic substitution transmetalation}, volume = {64}, year = {2025}, }
• (2025). Chloromethoxytrityls: Tuning the SOMO level of stable luminescent radicals. ANGEW, 64(37), e202512411. (www)

  @article{ , abstract = {Luminescent radicals are of significant recent interest because of the unique quantum properties of the doublet excited state. Control of the energy level of the singly-occupied molecular orbital (SOMO) is essential for the design and application of open-shell materials, but most triarylmethyl radicals are very electron-poor and exhibit similar SOMO values. In this work, we show how a combination of chlorine and methoxy substituents in triarylmethyl radicals allows tuning of their SOMO level over a wide range of –5.7 to –3.9 eV. We demonstrate that both methoxy and chlorine groups provide sufficient stabilization of the radical against peroxide formation, but one-electron oxidation in air limits the SOMO ≤ -4.5 eV to maintain bench stability. Two new stable radicals are characterized by X-ray crystallography, cyclic voltammetry, and luminescence measurements in solution and doped films. We show that the combination of chlorine and methoxy substituents improves the photostability of triarylmethyl radicals compared to tris(trichlorophenyl)methyl (TTM). The extraordinarily large range of SOMO levels in these radicals provides an opportunity to benchmark computational methods for predicting redox potentials. We find that most common density functional theory functionals and even coupled-cluster (CCSD) calculations overestimate the substituent effects in these open-shell species.}, archive = {J_ANGEW}, author = {Hannah E. Hackney and Cory Ruchlin and Emil Stahle and Dmytro F. Perepichka}, doi = {10.1002/anie.202512411}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512411}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chloromethoxytrityls: Tuning the SOMO level of stable luminescent radicals}, volume = {64}, year = {2025}, }
• (2025). Synthesis of thiophenes from pyridines using elemental sulfur. ANGEW, 64(37), e202512321. (www)

  @article{ , abstract = {We describe a skeletal editing of pyridines to afford thiophenes through a formal [4 + 1] reaction using elemental sulfur. 2-Arylpyridines are converted to ring-opened aza-triene Zincke ketone structures, followed by simple treatment with sulfur to give 2-aroylthiophene products directly. The amphiphilic character of octasulfur enables smooth reaction with the Zincke dienamine, affording the cyclized products under mild and neutral conditions. We illustrate this new disconnection with a synthesis of the anti-inflammatory drug suprofen from a pyridine starting material.}, archive = {J_ANGEW}, author = {Zi Liu and Michael F. Greaney}, doi = {10.1002/anie.202512321}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512321}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of thiophenes from pyridines using elemental sulfur}, volume = {64}, year = {2025}, }
• (2025). Feedstock-derived thiophene radical anions exhibiting redox stability at extreme potentials. ANGEW, 64(37), e202512271. (www)

  @article{ , abstract = {Organic radicals that are both readily synthesized from commodity chemicals and stable at extreme redox potentials are rare, yet highly desirable for applications in energy storage and organic electronics. Herein, we report feedstock-derived thiophene radical anions bearing ester functionalities that undergo galvanostatic charge–discharge redox cycling at potentials below −2 V versus Fc/Fc + (Fc = ferrocene). Systematic structural modification led to the identification of a derivative exhibiting exceptional redox stability, showing promise as a scalable and low-cost electrolyte for electron storage applications. Further, a crystalline thiophene radical anion was isolated and characterized using structural, spectroscopic, and computational methods. These studies revealed that the ester functionalities stabilize the reduced “quinoidal” thiophene electronic structure without the need for extended π-delocalization. Taken together, a new class of electron storage media is reported that combine redox stability at extreme potentials with straightforward synthesis, while offering rare insight into the structural and electronic features of stable thiophene radicals.}, archive = {J_ANGEW}, author = {Aurelio C. Gasser and Daniel Käch and Máté J. Bezdek}, doi = {10.1002/anie.202512271}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512271}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Feedstock-derived thiophene radical anions exhibiting redox stability at extreme potentials}, volume = {64}, year = {2025}, }
• (2025). Platinum-catalysed hydrofluorination of alkynes at room temperature promoted by a fluoride shuttle. ANGEW, 64(37), e202512181. (www)

  @article{ , abstract = {Hydrofluorination of alkynes provides a synthetic route to access fluoroalkenes, a class of compounds with wide applications in chemical research. Herewith, we describe an exceptional hydrofluorination process of alkynes catalysed by Pt(II) complexes at room temperature. Various Pt(II) dichloride complexes bearing chelating phosphines were synthesised and studied towards their catalytic behaviour. Mechanistic investigations suggest the involvement of a dicationic Pt(II) bis(alkyne) species as well as a cationic ß -fluorovinyl Pt(II) complex in the catalytic cycle. Remarkably, the hydrofluorination is enabled by fluorinated anions. The corresponding acids BF 3 , HF as well as PF 5 act as fluoride shuttles to allow for an outer-sphere fluorination of the metal-bound substrate. Detailed DFT analyses for BF 3 show that the hydrofluorination is mediated by complexes between the fluorinated anion and HF. This lowers the hydrofluorination barriers sufficiently to outcompete the simultaneously occurring, more exergonic cyclisation of two coordinated alkynes to a structurally characterised cycloallyl complex. The catalytic system can be applied to a wide substrate scope to generate fluoroalkenes bearing bulky alkyl, aryl and electron withdrawing groups, such as ester and carbonyl substituents.}, archive = {J_ANGEW}, author = {Ouchan He and Froze Jameel and Hannah Flammang and Smrithi Suresh Babu and Martin Kaupp and Thomas Braun}, doi = {10.1002/anie.202512181}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512181}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Platinum-catalysed hydrofluorination of alkynes at room temperature promoted by a fluoride shuttle}, volume = {64}, year = {2025}, }
• (2025). Plasma-engineered sub-10 nm surface fluorination enables ultraselective hollow fiber membranes. ANGEW, 64(37), e202512119. (www)

  @article{ , abstract = {While polymeric hollow fiber membranes (HFMs) offer scalable solutions for gas separations, their performance is fundamentally limited by the permeance-selectivity tradeoff and imprecise microporosity regulation. Herein, we propose a surface fluorination strategy using carbon tetrafluoride (CF 4 ) plasma to engineer a sub-10 nm fluorinated and crosslinked layer on polydimethylsiloxane (PDMS)-coated Matrimid ® HFMs. Through precise modulation of plasma parameters, we achieved controlled substitution of PDMS methyl groups/methyl hydrogen atoms with fluorine species (up to 27.7 mol% F content), 5.3-fold enhanced chain rigidity via fluorine-induced interchain interactions and steric hindrance, as well as narrowed pore size distribution with preferential ultra-micropore filling. The optimized HFM-50W-65Pa-500s membrane exhibits record-breaking He/N 2 and He/CH 4 selectivities of 1202 ± 13 and 1790 ± 12 with 170 ± 2 GPU He permeance, surpassing perfluoropolymer upper bounds and outperforming previously reported polymeric HFMs. Remarkably, it demonstrates molecular discrimination precision (α(He/CO 2 ) = 56 ± 2.2, α(He/H 2 ) = 4.1 ± 0.2) for pure-gas and attractive ternary He/(CO 2 +CH 4 ) selectivity of 1005 ± 20 under 40-bar mixed-gas conditions while maintaining 720-h operational stability. This plasma-engineered fluorination paradigm combines nanoscale precision with industrial scalability, opening new avenues for advanced membrane design.}, archive = {J_ANGEW}, author = {Can Wang and Xiaobo Chen and Xing Liu and Zhenyuan Li and Ruixia Liu and Shuangjiang Luo and Suojiang Zhang}, doi = {10.1002/anie.202512119}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512119}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plasma-engineered sub-10 nm surface fluorination enables ultraselective hollow fiber membranes}, volume = {64}, year = {2025}, }
• (2025). Highly efficient CO2 electroreduction in artificial seawater electrolyte catalyzed by strong-Acid/Base-resistant MOF. ANGEW, 64(37), e202512100. (www)

  @article{ , abstract = {NaCl, a primary component of seawater, is a cost-effective alternative electrolyte for CO 2 electroreduction; however, suppressing competitive hydrogen evolution reaction (HER) remains a challenge for efficient CO 2 RR. Herein, a novel Zn-MOF {[Zn 5 (tz) 6 (HCOO) 4 ]·2H 2 O} n ( 1 , Htz = 1,2,3-triazole) was prepared, exhibiting excellent stability in 0.5 M NaCl electrolyte for 16 weeks. 1 could maintain crystalline structure even after exposure to 9 M HCl and 2 M NaOH solutions. 1 achieved high selectivity for the electroreduction of CO 2 to CO with a maximum faradaic efficiency (FE CO ) of 94.4% under −1.5 V in artificial seawater electrolyte and 91.1% FE CO in treated natural seawater under −0.8 V, maintaining performance over 20 h. The mechanism analysis demonstrated that micropores in 1 could anchor coordinated H 2 O in [Na(H 2 O) 5 ] + to form a cationic layer at the particle surface, inhibiting the competitive HER and enhancing catalytic activity. Moreover, 1 could be applied in hectogram-scale production with low cost of US$ 0.01405 g −1 , showing promising industrial potential in CO 2 RR. This work addresses a critical challenge of the strongly competitive HER in Na-based electrolytes during electrochemical CO 2 RR, offering a feasible strategy for designing stable, efficient, and economical catalysts for sustainable energy applications.}, archive = {J_ANGEW}, author = {Le-Yan Li and Xin-Yuan Zhao and Meng-Hua Tang and Zhi-Wen Yang and Fang-Yu Ren and Ze-Long Liang and Peng-Fei Guo and Hang Xu and Xiang-Yu Zhang and Jian Zhao and Bin Zhao}, doi = {10.1002/anie.202512100}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512100}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient CO2 electroreduction in artificial seawater electrolyte catalyzed by strong-Acid/Base-resistant MOF}, volume = {64}, year = {2025}, }
• (2025). The design of interfacial organic-riched phase by molecular interlocking for stable zn anodes. ANGEW, 64(37), e202512032. (www)

  @article{ , abstract = {Rechargeable aqueous zinc-ion batteries (ZIBs) are promising energy storage devices due to their high safety and environmental friendliness. However, they suffer from some issues in Zn anodes, including dendrites, hydrogen evolution reaction, and byproducts. Herein, an organic-riched phase (ORP) layer was constructed on Zn anode by introducing sodium anthraquinone-1-sulfonate (AQS) into the aqueous electrolyte with ethylene glycol (EG). In such an electrolyte, the zincophilic -SO 3 − groups of AQS molecules preferentially adsorb on Zn anodes, and stable chemical bonds are achieved between them. After that, the low-polarity and hydrophobic anthraquinone group in the AQS layer tends to repel H 2 O molecules. Simultaneously, more AQS and EG molecules are attracted and migrate toward AQS layer due to polar compatibility, constructing the AQS/EG-riched layer on the Zn anode by the interlocking effect among them. When Zn 2+ solvated structures migrate through the ORP layer on Zn anode surface, AQS and EG molecules enter Zn 2+ solvated structures, and thus, the solvated H 2 O molecules are removed. As a result, hydrogen evolution and side reactions were significantly suppressed, and the Coulombic efficiency of Zn anodes during plating/stripping process reached 99.56%. To illustrate the feasibility of the ORP layer, Zn||V 2 O 5 full cells were assembled and exhibited superior cycling performance.}, archive = {J_ANGEW}, author = {Min Yang and Yanan Zhang and Qingjie Li and Xiao Wang and Buyu Ma and Zhiqiang Niu}, doi = {10.1002/anie.202512032}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512032}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The design of interfacial organic-riched phase by molecular interlocking for stable zn anodes}, volume = {64}, year = {2025}, }
• (2025). Molecular-metallic binding characteristics of the intermetalloid f-/p-block cluster [(La@In2Bi11)2Bi2]6−. ANGEW, 64(37), e202512019. (www)

  @article{ , abstract = {Main goals of contemporary research in chemistry are to create new materials with unique properties and to understand the chemical bonding in them, especially between metal atoms in larger structures. The isolation of a single lanthanide atom in a In/Bi cage offers a non-standard bonding situation, which deserves thorough exploration. In this study, the bonding behavior of La, In, and Bi atoms in the ternary cluster [(La@In 2 Bi 11 ) 2 Bi 2 ] 6− and the complex [La(C 5 Me 4 H) 3 ] used for its synthesis are characterized and compared by applying high energy resolution X-ray spectroscopy and computations. A clearly detectable covalent La(5d)─Bi(6p) interaction, induced in a highly electron-rich environment, is illustrated. The electronic structure of the La atom can be described as having the character of an ion being trapped and bonded in a heterometallic Bi/In cage. The advanced X-ray spectroscopic experimental tools applied here enable comparative studies of binding properties, focusing on different metals within the intermetalloid cluster. These tools can be employed iteratively to support the development of synthetic strategies that aim at tuning bond characteristics at the boundary of covalent and metallic bonding, thereby advancing the chemical and physical properties of novel multinary cluster compounds. The results were corroborated by GW and Bethe–Salpeter-equation ( GW -BSE) calculations.}, archive = {J_ANGEW}, author = {Harry Ramanantoanina and Julia Rienmüller and Yannick R. Lohse and Nina Rauwolf and Max Kehry and Cedric Reitz and Emily Marie Reynolds and Tim Prüßmann and Bianca Schacherl and Viktoriia A. Saveleva and Ruwini S. K. Ekanayake and Jörg Göttlicher and Bastian Weinert and Wim Klopper and Stefanie Dehnen and Tonya Vitova}, doi = {10.1002/anie.202512019}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202512019}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular-metallic binding characteristics of the intermetalloid f-/p-block cluster [(La@In2Bi11)2Bi2]6−}, volume = {64}, year = {2025}, }
• (2025). Thermally activated delayed fluorescence materials featuring multipathway charge transfer for high-efficiency BT.2020-compliant deep-blue OLEDs. ANGEW, 64(37), e202511921. (www)

  @article{ , abstract = {BT.2020-compliant deep-blue emitters for organic light-emitting diodes (OLEDs) are in high demand to achieve a wide color gamut for ultrahigh-definition displays. Herein, we report deep-blue thermally activated delayed fluorescent emitters featuring a unique donor1-donor2-acceptor (D 1 -D 2 -A) molecular configuration in which C 1 -N linked carbazole derivatives serve as dual-function donors and an oxygen-bridged triarylboron unit acts as the acceptor. The new design strategy focuses on constructing excited states with multipathway charge transfer characteristics—including multiresonance, through-bond, and through-space charge transfer—by precisely tuning the relative electron-donating strengths of the D 1 and D 2 units. Experimental and theoretical studies reveal that the optimized emitter, BO-BTC, achieves a well-balanced trade-off among emission efficiency, color purity, singlet–triplet energy gap, and horizontal dipole orientation ratio. Consequently, OLEDs using BO-BTC as the terminal emitter or as the sensitizer for ν -DABNA achieve high-efficiency deep-blue electroluminescence, with external quantum efficiencies of up to 24.7% and 37.9%, Commission Internationale de l’Éclairage-y values of 0.038 and 0.106, respectively.}, archive = {J_ANGEW}, author = {Yufu Sun and Xi-Feng Fu and Chen-Lu Hou and Ting-Ting Lin and Dong-Hai Zhang and Jin Liu and Jia-Xuan Hu and Fu-Lin Lin and Liang Zhou and Lingyi Meng and Xu-Lin Chen and Can-Zhong Lu}, doi = {10.1002/anie.202511921}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511921}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermally activated delayed fluorescence materials featuring multipathway charge transfer for high-efficiency BT.2020-compliant deep-blue OLEDs}, volume = {64}, year = {2025}, }
• (2025). Halogen-driven ion transport homogenization in 3D hierarchical MOF for ultrastable solid-state lithium metal batteries. ANGEW, 64(37), e202511822. (www)

  @article{ , abstract = {Solid-state lithium metal batteries (SSLMBs) are hindered by limited ionic conductivity, heterogeneous lithium flux and interfacial instability of solid-state electrolytes. Herein, we report a hierarchical ion-transport network formed by confining lithium halides (LiX, X═Cl, Br, I) within the mesoporous cages of MIL-100(Al), synergistically integrated with a PVDF-HFP polymer matrix. The 3D interconnected pores (0.5–1 nm) of MIL-100(Al) not only spatially confine anions via size-selective sieving but also enable continuous Li⁺ transport through tunable host–guest interactions between the Lewis-acidic metal nodes and lithium halides. Among these, the LiI-embedded composite (E-LiI) exhibits a high Li⁺ transference number (0.88 at 25 °C) and favorable interfacial kinetics, attributed to strong anion coordination and homogeneous Li⁺ plating. Structural characterizations confirm uniform LiX distribution within the MOF framework. In addition, density functional theory (DFT) calculations and COMSOL simulation elucidate halogen-dependent desolvation energetics and Li + transport kinetics. SSLMBs employing E-LiI electrolytes demonstrate exceptional cycling stability (capacity retention ∼100% after 600 cycles at 2C) with high-voltage cathodes and wide-temperature adaptability. This work advances the rational design of multi-scale ion-conductive frameworks and the pivotal role of lithium halide in regulating Li deposition kinetics, offering a transformative strategy for high-energy-density solid-state battery systems.}, archive = {J_ANGEW}, author = {Xingxing Zhang and Hongli Chen and Qingmei Su and Xinglong Deng and Dequn Zhao and Weihao Shi and Liming Wang and Jinqi Chen and Fan Xi and Zeming He and Ping Yu and Guoxiu Wang and Wenhuan Huang}, doi = {10.1002/anie.202511822}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511822}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogen-driven ion transport homogenization in 3D hierarchical MOF for ultrastable solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Catalytic enantioselective diboration of 1,2-dihydropyridines. ANGEW, 64(37), e202511813. (www)

  @article{ , abstract = {Dihydropyridines undergo enantioselective 1,4-diboration in the presence of a chiral Pt-based catalyst. The resulting diboryl piperidines can undergo diverse stereospecific cross-couplings, allowing the construction of an array of different substituted chiral piperidines. Density functional theory (DFT) calculations provide insight into a plausible diboration pathway that involves a platinum-centered reaction between coordinated B 2 L 2 reagent and the diene to furnish an intermediate π–allyl platinum complex.}, archive = {J_ANGEW}, author = {Hao Liang and James P. Morken}, doi = {10.1002/anie.202511813}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511813}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic enantioselective diboration of 1,2-dihydropyridines}, volume = {64}, year = {2025}, }
• (2025). Ethynylsulfone-based phenol-yne click polymerization toward multiple stimulus-responsive poly(β-aryloxylvinylsulfone)s. ANGEW, 64(37), e202511806. (www)

  @article{ , abstract = {We reported a metal-free ethynylsulfone-based phenol-yne click polymerization for the efficient synthesis of stereoregulated poly( β -aryloxylvinylsulfone)s (PAVSs), a new class of polymers exhibiting inherent responsiveness to multiple stimuli. This polymerization exhibits superior reactivity, yielding high-molecular-weight polymers whose stereochemistry ( Z / E configuration) can be precisely modulated by catalysts, monomer concentration, and solvents. The resulting Z - and E -enriched PAVSs demonstrate distinct thermal and mechanical properties, highlighting the impact of stereochemical control on material performance. Furthermore, new stimulus-induced transformations have been developed on the PAVS platform. A catalyst-free amine exchange reaction enables both precise polymer degradation and direct polymer-to-polymer conversion under mild conditions. Moreover, an unprecedented C═C bond cleavage reaction between PAVSs and N,N' -diethylethylenediamine affords methylated products, representing a rare example of alkene bond scission via simple diamine treatment. A photoinduced rearrangement reaction has also been established, leading to significant fluorescence enhancement upon UV irradiation. This photochemical behavior underpins potential applications in secure information encoding and encrypted communication.}, archive = {J_ANGEW}, author = {Xinyao Fu and Daming Zhou and Bo Song and Anjun Qin and Ben Zhong Tang}, doi = {10.1002/anie.202511806}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511806}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ethynylsulfone-based phenol-yne click polymerization toward multiple stimulus-responsive poly(β-aryloxylvinylsulfone)s}, volume = {64}, year = {2025}, }
• (2025). Chemically cross-linked polybenzimidazole membranes with ion-conductive sub-nanometer channels for Zinc–Iron flow batteries. ANGEW, 64(37), e202511744. (www)

  @article{ , abstract = {Ion-selective membranes with sub-nanometer micropores are essential in various separation processes and energy-related devices. However, the absence of molecular-level insights into ion transport behavior in sub-nanochannels challenges the accurate construction of fit-for-purpose membranes. Herein, we design cross-linked polybenzimidazole membranes with varying angstrom-scale pores and functional group densities by in situ crosslinking reaction during dual-coagulation bath-induced phase separation process. The modulation of pore architecture and pore chemistry enables precise control of ion transport under confined channels. Molecular dynamics simulations and experimental results reveal that ion dehydration and ion–pore wall interactions are the two dominant mechanisms governing fast and selective ion transport within charged sub-nanometer channels. Based on “dehydration–diffusion” mechanism, membranes with low steric hindrance and weak ion–pore wall interactions facilitate low-energy-barrier ion transport. We demonstrate their applications in alkalescent zinc–iron flow batteries, achieving a high peak power density of 607.8 mW cm −2 and energy efficiency exceeding 80% at a current density of 200 mA cm −2 . Our study advances the understanding of ion transport in membranes with sub-nanometer pores and provides guidelines for designing next-generation ion-selective membranes by regulating channel size and channel chemistry.}, archive = {J_ANGEW}, author = {Yuqin Huang and Chenyi Liao and Qilei Song and Zhizhang Yuan and Xianfeng Li}, doi = {10.1002/anie.202511744}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemically cross-linked polybenzimidazole membranes with ion-conductive sub-nanometer channels for Zinc–Iron flow batteries}, volume = {64}, year = {2025}, }
• (2025). Transition metal-free formal C─H/C─H coupling of arylacetamides and sulfoxides: An interrupted pummerer/[2,3]-sigmatropic rearrangement sequence. ANGEW, 64(37), e202511703. (www)

  @article{ , abstract = {Arylacetamides are important structural motifs found in many bioactive compound classes. Given their significance, the selective decoration of arylacetamides by transition metal-catalyzed C─H activation has attracted considerable attention. Here, we report a two-step transition metal-free formal C─H/C─H coupling of arylacetamides with sulfoxides that proceeds via the formation and rearrangement of little-known α-amido sulfonium salts; the amide motif “catches” the sulfoxide partner prior to its delivery to the ortho -position of the aromatic ring by rearrangement of a sulfur ylide intermediate. The approach delivers alkylated arylacetamides bearing sulfide functional handles that can be exploited in downstream manipulations. This protocol has allowed the synthesis of a dopamine D1 receptor allosteric modulator without recourse to the use of transition metals.}, archive = {J_ANGEW}, author = {Shibo Zhang and Ying Xin Lou and Allya Larroza and Ben W. Joynson and Ciro Romano and David J. Procter}, doi = {10.1002/anie.202511703}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511703}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transition metal-free formal C─H/C─H coupling of arylacetamides and sulfoxides: An interrupted pummerer/[2,3]-sigmatropic rearrangement sequence}, volume = {64}, year = {2025}, }
• (2025). Radical C─H-aroylation of allenes via cooperative photoredox and N-heterocyclic carbene catalysis. ANGEW, 64(37), e202511689. (www)

  @article{ , abstract = {This study demonstrates the use of cooperative photoredox and N -heterocyclic carbene (NHC) catalysis for sp 2 C─H acylation of allenes. The cascade comprises oxidative generation of an allene radical cation from an allene, its nucleophilic trapping to the corresponding allyl radical and highly regioselective cross coupling by a concomitantly reductively generated NHC-derived ketyl type radical. Ionic fragmentation of both the NHC and nucleophile ultimately yields the desired substituted allene. The organic photocatalyst, 4CzIPN, is highly effective in promoting both oxidative and reductive electron transfer steps. Tri- and tetra-substituted allenes can be obtained in good yields through such a cascade. Mechanistic studies—including radical trapping, acylazolium reactions, and Stern–Volmer quenching—support the proposed mechanism. Moreover, follow-up chemistry is conducted to demonstrate the synthetic value of the cascade products.}, archive = {J_ANGEW}, author = {Shyam Kumar Banjare and Lena Lezius and Armido Studer}, doi = {10.1002/anie.202511689}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511689}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radical C─H-aroylation of allenes via cooperative photoredox and N-heterocyclic carbene catalysis}, volume = {64}, year = {2025}, }
• (2025). Fully exposed silver clusters enabling highly efficient photocatalytic H2O2 production in pure water. ANGEW, 64(37), e202511687. (www)

  @article{ , abstract = {Photocatalytic production of H 2 O 2 in pure water holds great potential for sustainable industry. However, this prospect is greatly hindered by its sluggish reaction kinetics involving multistep electron transfer and unstable intermediates. Herein, the fully exposed silver (Ag) clusters were anchored on poly(heptazinimide) (PHI) catalyst, forming a new kind of fully exposed cluster catalysts (FECCs), which can boost photocatalytic generation of H 2 O 2 in pure water, with a rate up to 1075.5 µmol g −1 h −1 , surpassing its Ag single atoms counterpart and many recent-reported state-of-the-art photocatalysts. In situ characterization and DFT analysis showed that fully exposed Ag clusters can form the electron-rich centers and optimize the binding energy of the O 2 and proton H, which in turn enhances the protonation process of *OOH, reducing the energy barrier of key steps, and finally leading to a high yield of H 2 O 2 . Interestingly, its Ag single-atom counterpart was favorable for decomposing the H 2 O 2 into ·OH. Thus, Ag FECCs achieve significantly enhanced tetracycline degradation efficiency with the strategic incorporation of Ag single atoms.}, archive = {J_ANGEW}, author = {Qian Liu and Hao Bi and Ran Zhao and Xiaowen Yang and Fangyuan Chen and Zhurui Shen}, doi = {10.1002/anie.202511687}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511687}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fully exposed silver clusters enabling highly efficient photocatalytic H2O2 production in pure water}, volume = {64}, year = {2025}, }
• (2025). Ligand-to-metal charge transfer of Ag(II) CF2X carboxylates: Quantum yield and electrophotocatalytic arene fluoroalkylation tuned by x. ANGEW, 64(37), e202511642. (www)

  @article{ , abstract = {Incorporation of CF 2 X groups beyond CF 3 into arene scaffolds is underdeveloped despite these groups’ utility as halogen-bond donors and as precursors to bioisosteres. Herein, we report the synthesis, characterization, and comparative photochemistry of a suite of [Ag(II)(bpy) 2 O 2 CCF 2 X] + and Ag(II)(bpy)(O 2 CCF 2 X) 2 (bpy = 2,2´-bipyridine, X = F, CF 3 , Cl, Br, H, CH 3 ) carboxylate complexes. We find a dramatic effect of the X substituent on the efficiency of generating CF 2 X radicals by ligand-to-metal charge transfer (LMCT), with Ag(II) photoreduction rates varying by over an order of magnitude and quantum yields spanning over 20%. We provide insight into how electronic and structural perturbations of the Ag(II)–O 2 CCF 2 X core are manifested in the LMCT quantum efficiency. With this information in hand, Ag(II)-mediated electrophotocatalytic CF 2 X functionalization is carried out on a range of (hetero)arenes. This work expands the nascent field of Ag(II)-based photocatalysis by allowing for (hetero)aryl–CF 2 X functionalization directly from unactivated fluoroalkyl carboxylate precursors.}, archive = {J_ANGEW}, author = {Brandon M. Campbell and Jesse B. Gordon and Elaine Reichert Raguram and Kristopher G. Reynolds and Meghan G. Sullivan and Daniel G. Nocera}, doi = {10.1002/anie.202511642}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511642}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-to-metal charge transfer of Ag(II) CF2X carboxylates: Quantum yield and electrophotocatalytic arene fluoroalkylation tuned by x}, volume = {64}, year = {2025}, }
• (2025). In situ sulfur modification enables electrochemical selective deuterated Thiol–Yne reactions. ANGEW, 64(37), e202511623. (www)

  @article{ , abstract = {The deuterated thiol–yne reaction using D 2 O represents an attractive strategy for simultaneously introducing pharmaceutically relevant C(sp 2 )─D bonds and vinyl sulfide motifs. However, achieving high deuterium (D) incorporation remains a significant challenge. Herein, we report an electrochemical deuterated thiol–yne reaction that delivers D-containing vinyl sulfides with up to 98% alkene selectivity and 99% D incorporation, employing disulfides (RSSR) and D₂O over an in situ sulfur-modified nickel foam (NF) electrode. Mechanistic studies reveal a reductive cleavage of RSSR to RS⁻ intermediates, which subsequently form surface nickel sulfide (NiS x ) species through R─S bond cleavage. In situ and ex situ characterizations confirm the NiS x formation and its role in reducing alkene adsorption, thereby suppressing its overreduction. This strategy demonstrates broad applicability across terminal and internal alkynes, as well as aromatic and aliphatic disulfides, furnishing 30 diverse examples of D-labeled vinyl sulfides.}, archive = {J_ANGEW}, author = {Liyuan Lan and Ying Gao and Cuibo Liu and Bin Zhang and Kun Xu and Chengchu Zeng}, doi = {10.1002/anie.202511623}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511623}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ sulfur modification enables electrochemical selective deuterated Thiol–Yne reactions}, volume = {64}, year = {2025}, }
• (2025). Supramolecular engineering of cluster-assembled materials for amplification and dynamic modulation of chiral luminescence. ANGEW, 64(37), e202511554. (www)

  @article{ , abstract = {Chiral metal clusters have garnered significant research interest in recent years due to their unique photophysical and chiroptical properties. Increased attention is directed toward bimetallic systems, as the synergistic effect of two different metal centers often yields enhanced properties. Despite this progress, obtaining optically active bimetallic clusters with pronounced chirality, both in their ground and excited states, has remained a challenge. Herein, an efficient strategy is formulated for the controlled aggregation of gold(I)–silver(I) coordination clusters leading to enhanced and tunable optical activity. Interactions with chiral and achiral additives resulted in cluster-assembled materials (CAMs) exhibiting morphology-dependent chiroptical responses. The assembly process, in addition to facilitating aggregation-induced enhanced emission (AIEE), generated inverted and amplified chiroptical responses. Interestingly, the resultant Au(I)Ag(I) composite materials exhibited prolonged excited state lifetimes, indicating the possibility of near room temperature thermally activated delayed fluorescence (TADF) and lower temperature phosphorescence. Circularly polarized luminescence with a dissymmetry factor as high as (±)0.05 could be achieved, the highest reported for any metal cluster to date. The enhanced anisotropy highlights the effectiveness of this strategy in modulating excited-state chirality through hierarchical assembly, opening potential for the nanocomposites as chiral light-emitting materials.}, archive = {J_ANGEW}, author = {Camelia Dutta and Anannya Mandal and Abhishek Shukla and Elangovan Hemaprabha and Takuya Nakashima and Jatish Kumar}, doi = {10.1002/anie.202511554}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511554}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular engineering of cluster-assembled materials for amplification and dynamic modulation of chiral luminescence}, volume = {64}, year = {2025}, }
• (2025). Synthesis and structure of neopentyl sodium: A hydrocarbon-soluble reagent for controlled sodiation of non-activated substrates. ANGEW, 64(37), e202511492. (www)

  @article{ , abstract = {While recent studies have shown that organosodium reagents can offer excellent promise in organic synthesis, their widespread applications can be hindered by their limited solubility in organic solvents, lack of stability, and uncontrolled reactivity. Improving this immature area, here we report the structure of unsolvated neopentyl sodium, which exhibits a unique discrete tetrameric motif and good solubility in hexane. Combining spectroscopic and crystallographic studies with computational bonding analysis, key insights into its constitution and stability have been gained. Expanding its synthetic potential, supporting neopentyl sodium with Lewis donor PMDETA ( N,N,N′,N″,N″ -pentamethyldiethylenetriamine) allows for the direct metalation of challenging non-activated arenes and alkenes, including the regioselective meta -functionalisation of selected 1,3-disubstituted alkyl arenes. Shedding light on sodium-mediated metalation protocols, key organometallic intermediates have been isolated and structurally defined, which can subsequently be intercepted with CO 2 or a boron electrophile to be directly used in Pd-catalysed Suzuki cross coupling reactions.}, archive = {J_ANGEW}, author = {David E. Anderson and Lorraine A. Malaspina and Simon Grabowsky and Eva Hevia}, doi = {10.1002/anie.202511492}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511492}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and structure of neopentyl sodium: A hydrocarbon-soluble reagent for controlled sodiation of non-activated substrates}, volume = {64}, year = {2025}, }
• (2025). Ordered copper triangular atomic sites for industrial-grade electromethanation of CO2 via self-regulated adsorption of reactants. ANGEW, 64(37), e202511459. (www)

  @article{ , abstract = {Copper single-atom catalysts have shown considerable potential for electrocatalytic CO 2 reduction reaction (CO 2 RR) to methane but face constraints of low selectivity at industrial-grade current densities (>400 mA cm −2 ) and limited economic viability. Herein, we report an ion exchange strategy to precisely construct ordered Cu triangular atomic sites loaded on poly(heptazine imide) (Cu TAS/PHI), achieving a methane Faradaic efficiency (FE) of 80.5% at 400 mA cm −2 and >60% across 100–800 mA cm −2 . Remarkably, it enables CO 2 deuteration to high-value methane- d 4 with an FE of 75.1% at 700 mA cm −2 and an estimated annual return on investment of 425.35%. In situ spectroscopy and theoretical calculations demonstrate that Cu triangular atomic sites enable strengthened adsorption and activation of CO 2 , as well as balanced proton supply via self-regulated adsorption of reactants, thus favoring CO 2 deep hydrogenation over hydrogen evolution. Moreover, Cu TAS/PHI unlocks an energetically favorable *C(OH) 2 pathway, circumventing the conventional *CO pathway that typically yields diverse CO 2 RR products. This work demonstrates a strategy to construct ordered multiatomic sites for highly selective CO 2 RR at industrial-grade current density and highlights the extraordinary financial potential of electrocatalytic CO 2 RR to produce high-value deuterated chemicals.}, archive = {J_ANGEW}, author = {Fanglei Yao and Yuntong Sun and Long Nie and Cheng Zhang and Hongwei Shou and Zhiming Li and Xiaoping Gao and Jin Wang}, doi = {10.1002/anie.202511459}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ordered copper triangular atomic sites for industrial-grade electromethanation of CO2 via self-regulated adsorption of reactants}, volume = {64}, year = {2025}, }
• (2025). Dual co sites in n─n type heterojunction enable selective electrochemical co-valorization of HMF and CO2. ANGEW, 64(37), e202511448. (www)

  @article{ , abstract = {Electrocatalytic oxidation of biomass-derived hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) and electrocatalytic reduction of CO 2 into CO are two highly investigated areas. Efficient electrocatalytic system design that combines CO 2 valorization with biomass upgrading offers a viable solution to produce high-value chemicals and renewable energy at the same time. Here, we demonstrate an interfacial-engineered CoS/Co─N─C n─n type heterojunction featuring unique dual Co sites and strong built-in electric field (BEF) effects, which enables efficient electrochemical coupling of 5-hydroxymethylfurfural oxidation reaction (HMFOR) and CO 2 reduction reaction (CO 2 RR). The optimized catalyst achieves exceptional performance metrics, i.e., a record-low onset potential of 1.12 V (versus RHE), with 99% selectivity and 98.2% faradaic efficiency (FE) for 2,5-furandicarboxylic acid (FDCA) in HMFOR, coupled with 98.6% CO 2 ─to─CO selectivity and the FE average was retained 98.4% in CO 2 RR, which outperform the previously reported state-of-the-art electrocatalysts. Moreover, the integrated HMFOR//CO 2 RR system demonstrates impressive stability over 50 h continuous operation. Through systematic experimental examination and theoretical calculations, we reveal that the BEF boosts the formation of the unique dual Co coordination environments (Co─N 4 electron-deficient and Co─S electron-rich configurations) through modulation of charge transport dynamics, facilitating HMF activation through *OH intermediate stabilization while promoting multi-electron CO 2 reduction via charge accumulation. This work establishes a blueprint for developing multi-functional catalytic architectures that address the thermodynamic and kinetic challenges in coupled electrochemical systems, advancing the frontier of sustainable electrosynthesis technologies.}, archive = {J_ANGEW}, author = {Juntao Zhang and Di Yan and Guixiang Ding and Xusheng Wang and Chunxue Li and Sheng Zhong and Yaqin Yu and Li Shuai and Guangfu Liao}, doi = {10.1002/anie.202511448}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511448}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual co sites in n─n type heterojunction enable selective electrochemical co-valorization of HMF and CO2}, volume = {64}, year = {2025}, }
• (2025). PH-dependent packing mode variations and chirality inversion in short peptide self-assembly. ANGEW, 64(37), e202511407. (www)

  @article{ , abstract = {Precise control of structures and morphologies in peptide self-assembly has been challenging. We report the self-assembly of amphiphilic peptides I 3 H, designed with a modular structure featuring three consecutive isoleucine residues as a hydrophobic tail and a C-terminal histidine-based hydrophilic headgroup. Microscopic, neutron scattering, and spectroscopic techniques demonstrate that the designed peptides self-assemble into β-sheet nanofibrils, with their helix handedness exhibiting subtle pH-dependent inversion. pH titration, NMR, and molecular dynamics simulations reveal the underlying mechanism correlates with the protonation state of histidine and the molecular packing modes in β-sheet assemblies. The protonated histidine promotes antiparallel β-sheet packing at lower pH while its deprotonated state favors parallel packing when pH is increased. Strong π-π stacking interactions between deprotonated histidine side chains in parallel β-sheet arrangements drive chiral flipping of β-strands, ultimately inducing supramolecular helix inversion. Furthermore, such a pH-dependent helix inversion can be engineered by inserting the achiral and flexible glycine at the hydrophobic/hydrophilic interface, with I 3 GH assembly maintaining this effect while I 3 GGH assembly abolishing it. This work not only advances our mechanistic understanding of peptide chirality inversion at the level of individual β-sheets but also provides a blueprint for designing hierarchical chirality through precise modulation of molecular packing modes and side-chain interactions.}, archive = {J_ANGEW}, author = {Xiaoyue Ma and Kai Qi and Xinfeng Ju and Yawei Sun and Hua Yang and Yubin Ke and Jun Zhang and Yurong Zhao and Hai Xu and Jiqian Wang}, doi = {10.1002/anie.202511407}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511407}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PH-dependent packing mode variations and chirality inversion in short peptide self-assembly}, volume = {64}, year = {2025}, }
• (2025). Intercalation chemistry awakens transition metal hydroxide for boosted and sustained electrocatalytic sulfion oxidation. ANGEW, 64(37), e202511402. (www)

  @article{ , abstract = {Electrocatalytic sulfion oxidation reaction (SOR) is a sustainable approach to treat sulfion-rich sewage for S recovery. Transition metal hydroxide (TMOH), utilized in various electrocatalysis, yet is clumsy in SOR due to overstrong adsorption toward S-containing intermediates from unsuitable electronic structure. Herein we report, for the first time, that the SOR performance of TMOH can be awakened by intercalation chemistry. Take Co(OH) 2 as a proof-of-concept demonstration, MoO 4 2− intercalated Co(OH) 2 2D nanosheet array is engineered, and presents remarkably enhanced SOR behavior with an ultralow potential of 0.29 V versus RHE to attain 100 mA cm −2 , a record Tafel slope of 27.7 mV dec −1 , and stable operation for 192 h without appreciable deterioration. The experimental and theoretical studies unveil that MoO 4 2− -intercalated nanoarray is advantageous for active site exposure, and boosting mass transport with enhanced sulfion enrichment and superhydrophilicity. Impressively, MoO 4 2− intercalation can manipulate electronic structure of Co(OH) 2 with downshift of d-band center, thereby weakening binding strength with HS − and S 8 , and decreasing the |ΔG s* |, eventually enhancing both activity and stability. Notably, such intercalation wake-up strategy for the SOR is general and can be extended to other oxometallate intercalated TMOH systems. This contribution provides a new paradigm to evoke TMOH for SOR electrocatalysis via elegant intercalation tactic.}, archive = {J_ANGEW}, author = {Fengli Li and Wai Kwong NG and Wei Qiao and Yuting Yang and Xiaogang Li and Baojuan Xi and Yu Yu and Jingyun Fang and Ping Li and Shenglin Xiong}, doi = {10.1002/anie.202511402}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intercalation chemistry awakens transition metal hydroxide for boosted and sustained electrocatalytic sulfion oxidation}, volume = {64}, year = {2025}, }
• (2025). Ligand-controlled stereodivergent manganese-catalyzed hydroalkoxylation of alkynylnitriles to access (E)- and (Z)-3-alkoxyvinylnitriles. ANGEW, 64(37), e202511311. (www)

  @article{ , abstract = {Precise stereocontrol over functionalized alkenes remains a central challenge in organic synthesis. In particular, catalytic methods enabling flexible and stereodivergent synthesis of both trans -selective and cis -selective useful enol ethers are still underdeveloped. Herein, we report a manganese-catalyzed, ligand-controlled hydroalkoxylation of alkynylnitriles with alcohols under mild conditions. Through metal–ligand cooperation, a range of ( Z )- and ( E )-3-alkoxyvinylnitriles were obtained in high yields and with excellent selectivity by simply tuning the steric properties of PNP-pincer ligands: bulkier t Bu PNP–Mn catalyst favored Z -selectivity, while less hindered i Pr PNP–Mn catalyst led to E -selectivity. This method features a broad substrate scope, high functional group tolerance and exceptional chemo -, regio -, and stereo -selectivity. Mechanistic studies revealed that Z -products are initially formed in both cases, with the i Pr PNP–Mn catalyst further promoting isomerization to the thermodynamically favored E -isomers.}, archive = {J_ANGEW}, author = {Haobo Yang and Hui Huang and Yujie Wang and Sihui Long and Qiang Liu}, doi = {10.1002/anie.202511311}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511311}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-controlled stereodivergent manganese-catalyzed hydroalkoxylation of alkynylnitriles to access (E)- and (Z)-3-alkoxyvinylnitriles}, volume = {64}, year = {2025}, }
• (2025). Mitochondria-targeted molecular tools in precise tumor therapy. ANGEW, 64(37), e202511230. (www)

  @article{ , abstract = {Precise therapy for tumors faces challenges associated with traditional methods, such as low targeting efficiency, substantial side effects, and drug resistance. As the core regulators of cellular energy metabolism and apoptosis, mitochondria exhibit considerable advantages through targeted molecular tools that precisely deliver drugs, interfere with key pathways, and activate immune responses. This article reviews the latest advancements in mitochondria-targeted molecular tools for precision tumor therapy. Modifying molecular structures or designing functionalized carriers, small molecular drugs, metal complexes, nanodrugs, and polymeric drugs can be precisely enriched in mitochondria, disrupting the mitochondrial membrane, interfering with the respiratory chain, or activating immune pathways, thereby significantly enhancing antitumor efficacy and reducing systemic toxicity. However, further optimization of the design of mitochondria-targeted molecular tools is required, and their synergistic potential with immunotherapy metabolic regulation, and mitochondrial DNA targeting warrants further exploration. The rational design of mitochondria-targeted molecular tools holds great promise for achieving precise, personalized, and low-toxicity tumor therapy.}, archive = {J_ANGEW}, author = {Xing Wang and Yuqi Tang and Quan Li}, doi = {10.1002/anie.202511230}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511230}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mitochondria-targeted molecular tools in precise tumor therapy}, volume = {64}, year = {2025}, }
• (2025). Unraveling the mode of action of a neuron-specific fluorescent probe, NeuO: Intracellular phosphorylation through PAK6 kinase. ANGEW, 64(37), e202511160. (www)

  @article{ , abstract = {NeuO is an intriguing molecular probe capable of selectively labeling live neurons within a heterogeneous population of brain cells. The precise mechanism responsible for this neuronal labeling has remained a longstanding enigma. We investigated four potential mechanisms underlying NeuO's fluorescence, including its interaction with neuronal proteins, transportation into neurons, export from glial cells, and structural alterations within neurons. Our study found that NeuO undergoes structural changes via phosphorylation by the PAK6 kinase, resulting in high fluorescence in neurons, likely due to fluorogenic activation and intracellular retention within neurons. This discovery improves our understanding of the molecular mechanism of NeuO in neurons and facilitates the development of new chemical compounds that can be selectively modified by kinases in living cells.}, archive = {J_ANGEW}, author = {Beomsue Kim and Dongwan Ko and Sang-Bum Kim and Songhui Kim and Minji Kim and Na-Kyeong Hong and Sun You Park and Wonju Kim and Byoung-Cheol Lee and Yunbeom Lee and Taebo Sim and Young-Tae Chang}, doi = {10.1002/anie.202511160}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511160}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the mode of action of a neuron-specific fluorescent probe, NeuO: Intracellular phosphorylation through PAK6 kinase}, volume = {64}, year = {2025}, }
• (2025). Insight into how PETase functions at the solid-liquid interface and an activity-stability trade-off. ANGEW, 64(37), e202511131. (www)

  @article{ , abstract = {Enzymatic degradation of poly(ethylene terephthalate) (PET) has garnered considerable interest in plastic recycling efforts. However, the underlying molecular mechanism governing PETase-catalyzed PET depolymerization at the solid-liquid interface remains elusive, hampering the rational design of highly efficient enzymes. Here, we comprehensively elucidate the catalytic pathway of PETase, detailing steps from initial enzyme adsorption at the PET interface, subsequent substrate fragment capture, conformational refinement, to the ultimate cleavage of ester bonds. We uncover an intrinsic trade-off between the activity and stability of the enzyme's PET-binding loops, which negatively impacts overall PET degradation efficiency. By strategically reshaping the loop dynamics of PETase, we successfully overcome this compromise, simultaneously enhancing both enzymatic activity and structural stability. Collectively, this work provides critical insights into PETase functionality at solid-liquid interfaces and establishes valuable guidelines for the rational design of efficient plastic-degrading enzymes.}, archive = {J_ANGEW}, author = {Shuang Chen and Ekram Akram and Hui Liang and Weili Qiao and Yifei Zhang and Shozeb Haider and Yufei Cao}, doi = {10.1002/anie.202511131}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511131}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insight into how PETase functions at the solid-liquid interface and an activity-stability trade-off}, volume = {64}, year = {2025}, }
• (2025). Electro-responsive tri-state switch in supramolecular circuits. ANGEW, 64(37), e202511115. (www)

  @article{ , abstract = {Efficiently manipulating charge transport at the molecular level is critical to developing multifunctional and responsive molecular electronic devices. Here, we report the first electroresponsive tristate switch in a supramolecular circuit, overcoming the binary limitation and enabling richer logic encoding, governed solely by a bias voltage (electric field). At low electric fields, p -phenylenediamine (PPD) molecules exhibit a high-conductance state, which transitions successively to two distinct low-conductance states as the external electric field strength increases. This precise control of supramolecular junctions through electric field manipulation achieved an on/off ratio G H /G L of ∼1.25×10 3 , which is one of the largest values reported to date. Flicker noise analysis and density functional theory calculations reveal the intrinsic mechanism for the observation, i.e ., electric field promoting the formation of trimer supramolecular junctions leads to the striking on/off ratio. These findings provide new insights into the design of molecular circuits with tunable conductance, paving a way for the design of molecular computation, memory devices, and sensors.}, archive = {J_ANGEW}, author = {Min Tan and Xueyan Zhao and Zhibin Zhao and Adila Adijiang and Haibo Shu and Lichuan Chen and Zhiqiang Fan and Dong Xiang}, doi = {10.1002/anie.202511115}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511115}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electro-responsive tri-state switch in supramolecular circuits}, volume = {64}, year = {2025}, }
• (2025). Selective scission of orthogonal bonds in four-membered ring mechanophores upon activation by a rotaxane actuator. ANGEW, 64(37), e202511039. (www)

  @article{ , abstract = {Mechanophores (mechanosensitive molecules) are usually activated by pulling force transduced by polymer covalently attached to their structures. A variety of mechanophores have been described to date but many rely on a limited number of core structures. The diversity of products formed mechanochemically could be improved by promoting the scission of varied bonds within a single mechanophore. 4-membered rings are particularly suited for this as two sets of products can be obtained by formal retro-[2 + 2] cycloaddition depending on the pulling direction. This concept has been applied to a couple of mechanophores but the repositioning of the anchoring points often requires a redesign of the structures, and the pulling activation is not amenable to the release of the products. Here we show that the unique pushing activation of a rotaxane actuator enables the selective activation of covalent bonds parallel or perpendicular to the main chain in diazetidinone and β-lactam mechanophores. The selectivity depends on the orientation of the bulky substituents pointing toward or away from the incoming macrocycle. We were able to release ketene and triaryl imine/ethene molecules, and to generate imine, azobenzene, and isocyanate units. This alternative activation method demonstrates how to elicit new reactivity from known mechanophores and should inspire the design of new ones. The variety of structures released/generated here illustrate how this approach can be used for the release of reactive species and other functional molecules.}, archive = {J_ANGEW}, author = {Lei Chen and Guillaume De Bo}, doi = {10.1002/anie.202511039}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511039}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective scission of orthogonal bonds in four-membered ring mechanophores upon activation by a rotaxane actuator}, volume = {64}, year = {2025}, }
• (2025). Electron/Proton transport engineering in acylhydrazone-linked covalent organic framework for efficient solar-driven H2O2 production. ANGEW, 64(37), e202511024. (www)

  @article{ , abstract = {Hydrogen peroxide (H 2 O 2 ) is a vital industrial chemical extensively utilized in textiles, pharmaceuticals, and disinfection. Solar-driven photocatalytic technology depending on photocatalysts with matched energy band structure for simultaneously driving both O 2 reduction and water oxidation half-reactions, without necessary use of any sacrificial agent, enables green H 2 O 2 synthesis from O 2 and/or H 2 O, offering a low-energy and simple-operation process without secondary pollution while avoiding safety and environmental risk of conventional methods. Herein, a novel acylhydrazone-linked 2D COF, COF-S-OH , was prepared from benzo[1,2- b :3,4- b ':5,6- b '']trithiophene-2,5,8-tricarbaldehyde and 2,3-dihydroxysuccinohydrazide. Both experimental and theoretical analyses reveal that introduction of benzotrithiophene units and hydroxyl groups enhances the electron donor-acceptor effect in COF-S-OH , optimizes the light-harvesting and adsorption capacities to O 2 and H 2 O, and particularly enables efficient proton transfer, thereby synergistically improving photogenerated charge carrier separation and surface reaction efficiency. Consequently, COF-S-OH achieves an exceptional H 2 O 2 production rate of 10.2 mmol g −1 h −1 with a solar-to-chemical conversion efficiency of 2.1%, superior to all the thus far reported photocatalysts for H 2 O 2 synthesis. This work underscores the critical importance of carrier separation, active site, and proton supply in photocatalytic H 2 O 2 generation, providing guidance for designing and fabricating next-generation photocatalysts.}, archive = {J_ANGEW}, author = {Xiaolin Ma and Houhe Pan and Lei Gong and Xu Ding and Xing Zhou and Heyuan Liu and Rongming Wang and Chen Qu and Yanjun Zhao and Dongdong Qi and Yongzhong Bian and Jianzhuang Jiang}, doi = {10.1002/anie.202511024}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202511024}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron/Proton transport engineering in acylhydrazone-linked covalent organic framework for efficient solar-driven H2O2 production}, volume = {64}, year = {2025}, }
• (2025). Structural insights into phase formation of sodium layered cathodes materials with prominent electrochemical performances. ANGEW, 64(37), e202510981. (www)

  @article{ , abstract = {The electrochemical performances of layered cathodes for sodium-ion batteries (SIBs) are intimately dependent on their structural characteristics. However, realizing accurate regulation of structure by phase engineering is challenging, primarily due to constrained synthesis methods and the existing gaps in understanding of specialized phase structures. Herein, a series of P′2-Na 0.67 Fe 0.05 Ti 0.1 Mn 0.85 O 2 cathode material with prominent electrochemical performances were successfully synthesized, based on an in-depth understanding of structural insights into P′2 phase. By analyzing the structural evolution and Mn-valence changes during synthesis, we found that oxygen vacancies play a significant role in determining the P′2–P2 phase transition. Moreover, these insights not only identified the oxygen release and uptake behaviors in phase formation but also expanded synthesis strategy with enhanced operational feasibility. Benefits from expanded Mn redox range and stable oxygen vacancies during cycling, the obtained P′2-Na 0.67 Fe 0.05 Ti 0.1 Mn 0.85 O 2 demonstrated a capacity increase of over ∼40 mAh g −1 at 0.1 C, maintaining ∼93 mAh g −1 even after 1000 cycles at 10 C, with an impressive retention rate of 87.5%. This research significantly advances the comprehension of both synthesis mechanism and electrochemical properties optimization mechanisms of P′2 phase materials, offering a pragmatic strategy for elevating the performance of SIB materials.}, archive = {J_ANGEW}, author = {Haocheng Ji and Hengyu Ren and Guojie Chen and Wenhai Ji and Feng Zhou and Haotian Qu and Hui Fang and Mihai Chu and Rui Qi and Jingjun Zhai and Wen Zeng and Tiefeng Liu and Guangmin Zhou and Yinguo Xiao and Jun Lu}, doi = {10.1002/anie.202510981}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510981}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural insights into phase formation of sodium layered cathodes materials with prominent electrochemical performances}, volume = {64}, year = {2025}, }
• (2025). Constructing water-stable porous organic salts via suppressed proton integration using fluorinated tetrazole tectons. ANGEW, 64(37), e202510966. (www)

  @article{ , abstract = {Porous organic salts (POSs) are an emerging class of materials with ordered ionic architectures, offering excellent proton transfer and water uptake properties. However, conventional POS synthesis via strong acid–base neutralization (e.g., ─SO₃H and ─NH₂) leads to extensive hydrogen bonding with water, compromising stability in aqueous and water-lean environments. Here, we address this challenge by designing POSs with hydrophobic porous channels and minimal hydrogen bonding formation. Our key innovation is the use of fluorinated tetrazole as a weak acid tecton and a tetra-substituted imidazole precursor devoid of active protons as the base. Single-crystal analysis and computational modeling reveal that the structural integrity of the synthesized POSs arises primarily from cation–anion interactions, with water confined as clusters in the pores, independent of hydrogen bonding with the scaffold. Robustness of the POS structure under aqueous and water-lean conditions is confirmed by X-ray and neutron scattering, as well as computational modeling, confirming preserved packing and crystal structures. The stability of POS is further demonstrated in aqueous iodine capture, with imidazolium cations and C–F functionalizations serving as strong adsorption sites. The approach developed herein further pushes the boundary of POS materials to withstand both aqueous and water-lean conditions.}, archive = {J_ANGEW}, author = {Errui Li and Xian Suo and Yujing Tong and Phattananawee Nalaoh and David M. Jenkins and Carlos Alberto Steren and Lilin He and Alexander S. Ivanov and Leighanne C. Gallington and Victoria Cooley and Bo Li and Xin Wang and Kai Li and Juntian Fan and Liqi Qiu and De-en Jiang and Katherine R. Johnson and Takeshi Kobayashi and Murillo L. Martins and Shannon M. Mahurin and Zhenzhen Yang and Sheng Dai}, doi = {10.1002/anie.202510966}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510966}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing water-stable porous organic salts via suppressed proton integration using fluorinated tetrazole tectons}, volume = {64}, year = {2025}, }
• (2025). A bambusuril receptor binds charge diffuse anions in water at picomolar concentrations. ANGEW, 64(37), e202510912. (www)

  @article{ , abstract = {Anionic pollutants are widespread in the environment and pose risks to human health. Due to the typically low concentrations of these species, the development of efficient receptors for their detection and removal from aqueous solutions is highly desirable. Here, we report the design and synthesis of a bambusuril receptor with markedly enhanced anion-binding affinity in water, achieved by introducing trifluoromethyl electron-withdrawing groups. The resulting fluorinated receptor is, to date, the most potent known receptor for several charge diffuse anions in aqueous media. The most stable 1:1 host–guest complex in water was observed with iodide, exhibiting a relative dissociation constant of 59 pM. This complex is over three orders of magnitude more stable than any previously reported complex between an artificial receptor and inorganic anion in water.}, archive = {J_ANGEW}, author = {Surbhi Grewal and Petr Slávik and Vladimír Šindelář}, doi = {10.1002/anie.202510912}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510912}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bambusuril receptor binds charge diffuse anions in water at picomolar concentrations}, volume = {64}, year = {2025}, }
• (2025). Accessing N-unprotected unnatural α-amino acid esters by half-sandwich chiral-at-ruthenium aldehyde catalysis: Scope and mechanistic study. ANGEW, 64(37), e202510811. (www)

  @article{ , abstract = {Chiral aldehyde catalysis has emerged as an efficient and step-economical protocol for constructing unnatural α -amino acids and related esters. Herein, we report the application of a half-sandwich chiral-at-ruthenium complex featuring an aldehyde group as a versatile asymmetric catalyst with remarkably broad scope. Direct asymmetric α -C─H functionalization of N -unprotected glycine esters with four types of electrophiles (51 examples, all >91% ee) has been successfully realized for accessing structurally diverse unnatural α -amino acid esters. Gram-scale synthesis and successful catalyst recovery underscored the practicability and application potential of the present asymmetric aldehyde catalysis.}, archive = {J_ANGEW}, author = {Gang Chen and Gabriel N. Morais and Hui Liang and Jing Zhao and Chuanyong Wang and Shuming Chen and Jiajia Ma}, doi = {10.1002/anie.202510811}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accessing N-unprotected unnatural α-amino acid esters by half-sandwich chiral-at-ruthenium aldehyde catalysis: Scope and mechanistic study}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed regioselective and enantioselective Olefin–Aldehyde cross-couplings toward acyloin isosteres. ANGEW, 64(37), e202510690. (www)

  @article{ , abstract = {Bioisosteric replacement of ketones with three-dimensional (3D) motifs, such as oxetanes and azetidines, has emerged as a powerful tool in molecular design, enabling access to novel chemical space with improved pharmacokinetic profiles. However, general methods for the asymmetric synthesis of stereocenters adjacent to these strained, 3D frameworks remain scarce. Here, we report a nickel-catalyzed, enantioselective reductive cross-coupling between aldehydes and four-membered heterocyclic alkenes to construct α-hydroxy ketones bioisosteres with high efficiency and selectivity. Guided by N -heterocyclic carbene (NHC) ligands, the reaction proceeds with broad functional group tolerance, affording enantioenriched products in yields of up to 94% and an enantiomeric ratio (e.r.) of 99.8:0.2. The protocol is particularly amenable to the synthesis of enantioenriched α-hydroxy difluoromethylene alkanes. Mechanistic investigations revealed how strain-enabled reactivity and ligand control govern chemo-, regio-, and stereoselectivity. The synthetic utility of the method is demonstrated through gram-scale preparation and diverse downstream derivatizations, offering a versatile platform for accessing previously elusive classes of stereodefined bioisosteres.}, archive = {J_ANGEW}, author = {Mingshuai Zhang and Meihong Luo and Gang Zhao and Hongyu Wang}, doi = {10.1002/anie.202510690}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510690}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed regioselective and enantioselective Olefin–Aldehyde cross-couplings toward acyloin isosteres}, volume = {64}, year = {2025}, }
• (2025). Restructured three-coordinated Ni─Se catalytic sites for enhanced cross-condensation of methanol and ethanol. ANGEW, 64(37), e202510601. (www)

  @article{ , abstract = {The cross-condensation of methanol (MeOH) and ethanol (EtOH) offers a promising, carbon-neutral pathway for the production of higher alcohols (HAS) from both CO 2 and biomass resources. However, this process is often hampered by the low efficiency of C 5+ alcohol (C 5+ OH) synthesis, high catalyst production costs, and limited water tolerance. Here, we report for the first time a low-cost, high-performance Ni-based catalyst synthesized via a precise surface selenization protocol that effectively overcomes these limitations. The optimized catalyst significantly outperforms noble metal catalysts, achieving a total alcohol yield of 62.6% and a high selectivity of 83.8% for HAS (62.0% for C 5+ OH) in the cross-condensation of MeOH and EtOH. Our characterizations and theoretical simulations indicate that Se doping restructures the Ni surface, creating three-coordinated Ni─Se sites. These sites promote efficient alcohol dehydrogenation and raise the energy barrier for aldehyde decomposition, thereby greatly increasing the efficiency and selectivity of MeOH and EtOH cross-condensation to C 5+ OH.}, archive = {J_ANGEW}, author = {Juwen Gu and Qian Zhang and Yujian Fan and Guangyu Chen and Jiawei Li and Songbai Qiu and Tiejun Wang and Tian Sheng and Yujie Xiong}, doi = {10.1002/anie.202510601}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510601}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Restructured three-coordinated Ni─Se catalytic sites for enhanced cross-condensation of methanol and ethanol}, volume = {64}, year = {2025}, }
• (2025). Enhancing CO2 photoreduction efficiency through improved interaction enabled by a decorated covalent-organic framework. ANGEW, 64(37), e202510550. (www)

  @article{ , abstract = {Photoreduction of CO 2 is often hindered by the sluggish kinetics for its activation. Refinement of host–guest interactions is an effective strategy to overcome this barrier. Here, we report the immobilization of active Co(II) sites within a covalent-organic framework (COF) with a one-dimensional (1D) chain structure, Co-PyPDA-COF, which demonstrates a remarkable CO generation rate of 30.5 mmol g −1 h −1 and a high CO selectivity of 95.8% in 2 h for CO 2 photoreduction at room temperature. The pore size of Co-PyPDA-COF is comparable to the diameter of CO 2 , which allows simultaneous interaction of a single CO 2 molecule with the two Co(II) sites. The enhanced interaction result in increased local CO 2 pressure, limited CO 2 diffusion after adsorption, shortened distance for photoelectron transfer, and reduced energy barrier for the rate-determining step in CO 2 reduction, promoting CO 2 activation and conversion. This work opens a new way to design efficient catalysts by optimizing the pore size of the host.}, archive = {J_ANGEW}, author = {Wenling Zhao and Jiangnan Li and Ke Li and Jiapeng Jiao and Shiqiang Liu and Jiahao Yang and Mark D. Frogley and Yaguang Peng and Yiyong Wang and Hengan Wang and Shipeng Zhang and Lihong Jing and Chengcheng Liu and Sihai Yang and Xinchen Kang and Buxing Han}, doi = {10.1002/anie.202510550}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing CO2 photoreduction efficiency through improved interaction enabled by a decorated covalent-organic framework}, volume = {64}, year = {2025}, }
• (2025). Mechanochemical synthesis of recyclable biohybrid polymer networks using whole biomass. ANGEW, 64(37), e202510449. (www)

  @article{ , abstract = {Whole-plant biomass from non-agricultural sources and waste biomass from processing agricultural products are both promising feedstocks for biopolymer production because they are abundant and do not compete with food production. However, their processing steps are notoriously tedious with the final materials often displaying inferior performance and limited scope in their properties. Here, we report a strategy to integrate whole-cell spirulina, a green-blue algae, into robust biohybrid algae-polyimine networks by leveraging a mechanochemical ball milling method. This strategy provides a greener synthetic approach to conventional solvent casting methods for polyimine synthesis; it simultaneously overcomes persistent constraints encountered in biomass processing and derivatization. The biohybrid algae-based materials retain adaptability and recyclability imparted by their underlying dynamic covalent polymer matrix and display enhanced mechanical properties compared to their all-synthetic equivalents. These advantageous properties are attributed to the unique morphology of the ball milled biohybrid materials which are facilitated by integration of the spirulina into the polymer matrix. Substituting spirulina with alternative biomass sources such as waste agricultural products also yields robust biohybrid networks, thus highlighting the broad utility of this straightforward mechanochemical synthesis to create more sustainable materials.}, archive = {J_ANGEW}, author = {Meng Jiang and Emily Bird and Woojung Ham and Joshua C. Worch}, doi = {10.1002/anie.202510449}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510449}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanochemical synthesis of recyclable biohybrid polymer networks using whole biomass}, volume = {64}, year = {2025}, }
• (2025). 1,4-dearomatization of pyridines and quinolines enabled by the carbodication lewis acid. ANGEW, 64(37), e202510385. (www)

  @article{ , abstract = {1,4-Dihydropyridines (DHPs) are valuable compounds in medicinal chemistry and organic synthesis. The most straightforward pathway for preparing 1,4-DHPs is the direct 1,4-reduction of pyridines and quinolines. However, existing strategies are not effective for pyridines with electron-withdrawing substituents at the C2 position. To address this long-standing issue, a new strategy has been developed that utilizes underexplored carbodications as the Lewis acids to activate pyridines. For the first time, pyridines with -CN and -ester substituents at the C2 position have been successfully converted to 1,4-DHPs through direct reductive dearomatization in exclusive C4 selectivity. The potential utility of this 1,4-DHP synthetic protocol is demonstrated with C5-bromination, C5-trifluoromethylation, C5-deuteration, and C4-deuteration of pyridines using the in situ generated 1,4-DHPs as key intermediates.}, archive = {J_ANGEW}, author = {Xiaofeng Huang and Qiu Shi and Guoyin Lai and Wenbo H. Liu}, doi = {10.1002/anie.202510385}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510385}, shortjournal = {Angew. Chem. Int. Edit.}, title = {1,4-dearomatization of pyridines and quinolines enabled by the carbodication lewis acid}, volume = {64}, year = {2025}, }
• (2025). Mechanistic insights into the dissolution relay for deep progression of active sites toward efficient and ultralong-life energy storage. ANGEW, 64(37), e202510365. (www)

  @article{ , abstract = {Transition metal (oxy)hydroxides serve as efficient aqueous cathode materials but suffer from the challenge of structure degradation during long-term cycling applications. Achieving an ultralong service life, e.g., beyond 100 000 cycles, is highly desired for aqueous energy storage, which necessitates the precise cognition and modulation of the surface/interface microenvironment with prolonged cycling conditions. Herein, to address this issue, we for the first time engineer the competitive bonding and the electrochemical deep progression of NiCoCu medium-entropy hydroxides. The theoretical and experiment results indicate that Cu is prone to leaching from the medium-entropy hydroxides with cycling, which elevates the d/p-band centers to activate the lattice oxygen and Co atoms, triggering a Cu/Co dual-cation dissolution relay phenomenon. As-incorporated Co vacancies favor the β-to-γ phase transformation of the reconstructed structure, accompanied by the coordination oscillation and the production of ultrafine (∼1.9 nm) nanodomains with improved kinetics and stability. Consequently, capacity retention of 1485 C g −1 was achieved after 150 000 cycles for the reconstructed electrodes, which is superior to many state-of-the-art NiCo-based materials. This work elucidates the potential of the coordination reorganization and deep progression of the reaction microenvironment to break the performance limit of energy storage and beyond.}, archive = {J_ANGEW}, author = {Mingming Sun and Wei Guo and Jinxin Wang and Yu Xu and Qiuyu Zhang}, doi = {10.1002/anie.202510365}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510365}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanistic insights into the dissolution relay for deep progression of active sites toward efficient and ultralong-life energy storage}, volume = {64}, year = {2025}, }
• (2025). Surface engineered 2D-β-ketoenamine covalent organic framework for superior dechlorination via hybrid capacitive deionization. ANGEW, 64(37), e202510345. (www)

  @article{ , abstract = {To prevent a global water shortage crisis, we must innovate to desalinate seawater. Hybrid capacitive deionization (HCDI), an energy-efficient desalination method, depends on electrode materials. Removing chloride ions (Cl − ), a key salinity factor, is vital for balanced electrode capacity. Yet, efforts focus mainly on cathode materials for Na + capture, limiting the progress of electrochemical desalination. Herein, we have developed a covalent organic framework (COF)-based redox-active anode material with excellent chemical stability and unique pseudocapacitive behavior. In the HCDI cell, the rationally designed material showed a remarkable chloride ion removal capacity (Cl-RC) of 71.5 mg g −1 in 1300 ppm saline solution with a noteworthy removal capacity rate (Cl − RCR) of 1.85 mg g −1 min −1 , while maintaining 98.7% capacity retention over 30 cycles. Under optimized conditions, the COF electrode displayed a high selectivity toward Cl − over other anions present in real-seawater samples with Cl-RC of 89 mg g −1 , implying its practical applicability. To the best of our knowledge, this work represents the first example of a purposefully functionalized COF serving as an anode in HCDI, highlighting the promising role of COFs in advancing capacitive deionization technologies.}, archive = {J_ANGEW}, author = {Najat Maher Aldaqqa and Sushil Kumar and José Ignacío Martínez and Nada Elmerhi and Emad Alhseinat and Dinesh Shetty}, doi = {10.1002/anie.202510345}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510345}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface engineered 2D-β-ketoenamine covalent organic framework for superior dechlorination via hybrid capacitive deionization}, volume = {64}, year = {2025}, }
• (2025). Unconventional fast room temperature synthesis of covalent organic framework single crystals unveiling precise structural insights. ANGEW, 64(37), e202510312. (www)

  @article{ , abstract = {Two-dimensional covalent organic frameworks (COFs) are a special kind of crystalline polymers produced by the polycondensation reaction of organic linkers. However, the polymerization is often uncontrolled and conventionally yields polycrystalline powders. For that reason, the development of new methods to obtain single-crystalline COFs is an urgent need. Herein, we report a modulated, room-temperature, and fast synthesis of a highly fluorinated COF where the reaction conditions were systematically analyzed to yield single-crystalline rods of around three microns. The increase in crystal size enabled the analysis of precise structural features such as the mechanical properties or the different aggregation states of the bidimensional framework. In addition, the reaction mechanism was computationally elucidated, and the roles of the modulator agent and the catalyst were analyzed, confirming the critical importance of trifluoroacetic acid and 2,3,5,6-tetrafluoroaniline in modulating Schiff base bond formation and, consequently, the crystallinity of the resulting COF. This study reveals new insights into the crystallization of high-quality 2D COFs.}, archive = {J_ANGEW}, author = {Miguel Jiménez-Duro and Marcos Martínez-Fernández and Jorge J. Cabrera-Trujillo and Eva Osuna and Miguel Fernández-Ramos Humanes and Cristina Gómez-Navarro and Julio Gómez-Herrero and Félix Zamora and José L. Segura}, doi = {10.1002/anie.202510312}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unconventional fast room temperature synthesis of covalent organic framework single crystals unveiling precise structural insights}, volume = {64}, year = {2025}, }
• (2025). Pulsed electrocatalysis driven efficient ammonia synthesis by facilitating *NOOH formation and balancing *H supply. ANGEW, 64(37), e202510287. (www)

  @article{ , abstract = {Electrochemical nitrate reduction emerges as a promising approach for ammonia generation; however, its efficiency is hindered by the sluggish hydrogenation of nitrogen-containing intermediates and limited active hydrogen supply at constant applied potentials. Driven by the pulsed electrocatalysis, in this work, efficient nitrate-to-ammonia conversion is realized by facilitating *NOOH formation and balancing *H supply on a Janus Cu@Co/NC electrocatalyst. In detail, the Cu sites could activate NO 3 − at low overpotentials, while the Co sites could facilitate *NOOH formation with sufficient *H provided by the Co sites at high overpotentials. Promoted by the pulsed electrocatalysis technique, a maximum Faradaic efficiency of 98.32% with NH 3 yield rate of 12.75 mg h −1 mg cat −1 is attained, and the scaled-up pulsed electrosynthesis at industrial current densities is also achieved. This work underlines the feasibility of pulsed electrolysis for regulating intermediate hydrogenation, offering a promising approach for the synthesis of ammonia or other important chemicals.}, archive = {J_ANGEW}, author = {Zeyu Li and Zichen Shi and Yinggang Ou and Lixiang Zhong and Chunshuang Yan and Chu Zhang and Kai Song and Hengjie Liu and Daobin Liu and Pin Song and Chenhui Yin and Zeming Qi and Li Song and Chade Lv}, doi = {10.1002/anie.202510287}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510287}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pulsed electrocatalysis driven efficient ammonia synthesis by facilitating *NOOH formation and balancing *H supply}, volume = {64}, year = {2025}, }
• (2025). Bipyridine–Thiosumanene isomeric lewis bases for synergistic defect passivation and hole extraction enables over 26% efficient perovskite solar cells. ANGEW, 64(37), e202510255. (www)

  @article{ , abstract = {Interface defects between the perovskite layer and the hole transport layer (HTL) seriously limit the power conversion efficiency (PCE) and stability of perovskite solar cells (PSCs). Herein, we designed two isomers, 4BT and 5BT, based on 2,2′-bipyridine-thiosumanene-functionalized polycyclic aromatic hydrocarbons as novel Lewis bases with dual capabilities for deep-level defects (Pb 2+ , V I ) passivation and promoting hole extraction. By shifting the pyridine bridging unit from the tetra to the penta positions, these molecules undergo a configurational transformation from an orthogonal (4BT) to a planar structure (5BT). The configuration-functionality relationship was comprehensively investigated through theoretical and experimental analyses. The planar configuration of 5BT enables more Lewis base sites to interact with perovskite, exhibiting more pronounced deep-level defect passivation effect, while improving hole extraction capability. Consequently, the 5BT-modified n-i-p PSCs achieved a champion PCE of 26.15% (certified at 26.12%) and superior operational stability by retaining 94.0% of the initial PCE according to ISOS-L-2 protocol. This work offers a unique molecular designing mechanism to address the interfacial-related issues for high-performance PSCs.}, archive = {J_ANGEW}, author = {Zhongquan Wan and Yuanxi Wang and Yao Ma and Muhammad Azam and Boxue Zhang and Xiangfeng Shao and Runmin Wei and Haomiao Yin and Huaibiao Zeng and Junsheng Luo and Chunyang Jia}, doi = {10.1002/anie.202510255}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510255}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bipyridine–Thiosumanene isomeric lewis bases for synergistic defect passivation and hole extraction enables over 26% efficient perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Asymmetric coordinated single-atom catalysts offering zero-order sulfur redox kinetics for high performance Li–S batteries. ANGEW, 64(37), e202510212. (www)

  @article{ , abstract = {Accelerating the sluggish sulfur redox kinetics through electrocatalysis has been regarded as one of the key factors to achieve Li–S batteries of cell-level energy densities exceeding 600 Wh kg −1 . Though single-atom catalysts (SACs), typically with symmetric M-N 4 coordination structures have demonstrated attractive electrocatalytic performance in Li–S batteries, herein we discovered that an asymmetric-coordinated metal center distinctly shifts sulfur redox reaction (SRR) kinetics—from first-order (concentration-dependent) behavior in the symmetric-coordinated SACs—to zero-order (surface-saturated) kinetics, highlighting fundamentally altered reaction pathways, leading to a concurrent polysulfide conversion. Experimental and theoretical studies on the Ni atom-based SACs showed that symmetry breaking raises the Ni d-band center, enabling a monodentate-to-bidentate Li 2 S 4 adsorption transition, which strengthens polysulfide adsorption and shifts the rate-limiting step from sluggish solid-solid transformation (Li 2 S 2 → Li 2 S) to a more favorable liquid–solid conversion (Li 2 S 4 → Li 2 S 2 ), effectively lowering the overall energy barrier of the SRR process. Consequently, Li–S cells employing Ni-NPG, a SACs with asymmetric Ni-N 3 P 1 coordination, achieved a specific capacity of 877 mAh g −1 at 4 C. Even under a high sulfur loading of 6 mg cm −2 , the cell retained 92% of its capacity after 200 cycles at 0.2 C, outperforming conventional SACs with symmetric coordination structures.}, archive = {J_ANGEW}, author = {Xianghua Kong and Yifan Li and Guolei Cai and Wenchao Liu and Junjie Xu and Chuanfeng Liu and Guikai Zhang and Yilin Wang and Zhiyu Lu and Jing Zhang and Xiaojun Wu and Dawei Zhang and Hao Luo and Song Jin and Hengxing Ji}, doi = {10.1002/anie.202510212}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510212}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric coordinated single-atom catalysts offering zero-order sulfur redox kinetics for high performance Li–S batteries}, volume = {64}, year = {2025}, }
• (2025). Electrochemical alkyne semi-hydrogenation via proton-coupled electron transfer on cu(111) surface. ANGEW, 64(37), e202510192. (www)

  @article{ , abstract = {Electrocatalytic alkyne semi-hydrogenation (EASH) powered by renewable electricity using water as a hydrogen donor provides a sustainable alternative to conventional thermocatalysis. However, the current EASH systems predominantly follow hydrogen atom transfer (HAT) pathways, which are prone to over-hydrogenation and at the same time compete with the hydrogen evolution reaction. In this work, we report a proton-coupled electron transfer (PCET) mechanism enabled on Cu(111) surface for highly efficient and selective EASH. Well-defined two-dimensional Cu nanosheets with exposed (111) facets achieve > 98% selectivity for electrochemical semi-hydrogenation of 4-aminophenylacetylene to 4-vinylphenylamine in a membrane electrode assembly reactor. The Cu nanosheets can also efficiently remove 1%–8% alkyne impurities in alkene and exhibit broad substrate scope, stereoselectivity, as well as operational stability. In situ Raman spectroscopy measurements reveal that, during the PCET-mediated EASH, the covalent adsorption of alkynes and their conversion to weakly bound planar intermediates facilitate the EASH process and suppress over-hydrogenation. Interfacial K + -structured and linearly hydrogen-bonded water species further enhance EASH selectivity via proton supply and steric modulation. Radical scavenging and kinetic isotope effect studies, along with theoretical calculations, corroborate a PCET-dominated mechanism on Cu(111) surface. This work establishes a PCET-driven paradigm for selective hydrogenation beyond the conventional HAT pathways.}, archive = {J_ANGEW}, author = {Shangfeng Tang and Na Guo and Cheng Chen and Bingqing Yao and Xuan Liu and Chi Ma and Qiyuan Liu and Shan Ren and Chi He and Bin Liu and Xinzhe Li}, doi = {10.1002/anie.202510192}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510192}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical alkyne semi-hydrogenation via proton-coupled electron transfer on cu(111) surface}, volume = {64}, year = {2025}, }
• (2025). Tailoring a fast ion-conducting substrate with competitive adsorption for dendrite-free Lithium/Potassium metal batteries. ANGEW, 64(37), e202510178. (www)

  @article{ , abstract = {The desolvation behavior of Li + is widely regarded as primarily governed by the electrolyte composition, while the dynamic decoupling mechanism between the electrode interface and solvation structure has received limited attention. Herein, a competitive adsorption-driven, fast-ion-conducting host was innovatively developed based on the Li 15 Si 4 /Li 3 N microrods. Guided by density functional theory (DFT) calculations and molecular dynamics (MD) simulations, it was revealed for the first time that the dual-phase interface exhibits competitive adsorption interactions with solvent molecules and anions within the solvation sheath. This unique interfacial interaction triggers dynamic reconstruction of the solvation structure at the interface, significantly reducing the Li + desolvation barrier by 33%. Benefiting from the integration of these multifunctional advantages, the symmetric cell delivers an ultra-long cycle lifespan of over 5000 h at 1 mA cm −2 with an exceptionally low overpotential of 13 mV. Moreover, the full cell coupled with LiFePO 4 cathodes achieves an impressive cycling stability of 2000 cycles at 5 C, with a capacity retention of 107%. This work unveils a substrate-mediated solvation structure decoupling mechanism, offering a new paradigm for the rational design of dendrite-free Li metal anodes with 3D architectures.}, archive = {J_ANGEW}, author = {Jinlong Jiang and Jinshuang Liu and Xiaoyang Zheng and Laiquan Li and Jiawen Huang and Yuqin Wang and Shuo Guo and Ying Zhang and Xianzhong Yang and Jiayun Wen and Bing Zhao and Yong Jiang and Xueliang Sun and Jiujun Zhang and Chao Wu and Shixue Dou}, doi = {10.1002/anie.202510178}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510178}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring a fast ion-conducting substrate with competitive adsorption for dendrite-free Lithium/Potassium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Hinge-like mechanochromic mechanophores based on [2.2]Paracyclophane. ANGEW, 64(37), e202510114. (www)

  @article{ , abstract = {A hinge-like supramolecular mechanophore based on a [2.2]paracyclophane core and two excimer-forming 1,6-bis(phenylethynyl)pyrene luminophores is presented. Each luminophore shares one phenyl group with the [2.2]paracyclophane, resulting in a rigid and strained structure that forces the two luminophores into close proximity. As a consequence, the photoluminescence of the mechanophore in THF solution and in solid films of a polyurethane containing the new motif is dominated by excimer emission. Stretching the polymer films causes an easily discernible change from bright yellow excimer to blue–green monomer-dominated emission. The ratio of excimer to monomer emission intensities traces the nonlinear stress–strain curves of the polymer well and is a good indicator for the macroscopically applied force. The reversibility of the mechanoresponse, theoretical analyses, and reference experiments with a similar mechanophore in which the emitters and the [2.2]paracyclophane core are connected by flexible linkers support the conclusion that the mechanoactivation is caused by distorting the molecule into a bent, more open conformation and not the scission of covalent bonds. The operating principle was further confirmed by investigating a second hinge-like mechanophore based on a [2.2]paracyclophane core and 1,4-bis(phenylethynyl)benzene emitters.}, archive = {J_ANGEW}, author = {Shohei Shimizu and Jess M. Clough and Christoph Weder and Yoshimitsu Sagara}, doi = {10.1002/anie.202510114}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hinge-like mechanochromic mechanophores based on [2.2]Paracyclophane}, volume = {64}, year = {2025}, }
• (2025). A molecular staircase built from hydrazide-linked pyridines as an artificial proton channel. ANGEW, 64(37), e202510092. (www)

  @article{ , abstract = {Artificial proton channels exhibiting high selectivity remain largely unexplored, with only two such systems recently reported. Inspired by the DNA duplex's iconic helical structure, we present here a novel strategy for designing a molecular-scale staircase configuration. The resulting molecular staircase ( MS ), predominantly linear in shape, consists of pyridine units linked by hydrazide groups, with backbone rigidity enhanced by intramolecular H-bonding. This MS incorporates up to five proton-transporting motifs, demonstrating remarkable efficacy as a proton-conducting channel within lipid bilayer membranes. Our findings indicate that the MS exhibits high proton transport activity (EC 50 of 0.31 mol%, relative to lipids) and significant selectivity for protons, with selectivity values of 160.3 for K + , 90.5 for Na + , and 3.5 for Cl ⁻ . These results underscore the potential of the MS and its variants as a highly selective and efficient proton channel, advancing the field of artificial ion transport systems.}, archive = {J_ANGEW}, author = {Jianhe Xu and Yanbin Chen and Jianru Wang and Wenju Chang and Jie Shen and Huaqiang Zeng}, doi = {10.1002/anie.202510092}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202510092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A molecular staircase built from hydrazide-linked pyridines as an artificial proton channel}, volume = {64}, year = {2025}, }
• (2025). Heterointerface anchored ir with localized strong orbital coupling for durable proton exchange membrane water electrolysis. ANGEW, 64(37), e202509985. (www)

  @article{ , abstract = {The imperative to minimize iridium usage in proton exchange membrane water electrolysis (PEMWE) process presents a pivotal challenge for hydrogen economy deployment, while inherent destabilization of iridium (Ir) active sites under corrosive operational conditions, originating from insufficient Ir bonding strength, remains a fundamental barrier. Here, we resolve this dilemma through heterointerface-engineered stabilization, where the strategically constructed Nb-TiO 2 rutile/anatase heterophase homojunction stabilizes Ir sites with enhanced orbital overlap and intensified charge transfer. This atomic-scale anchoring mechanism, validated by operando characterization and theoretical calculations, strengthens Ir─O support bonding and optimizes *OOH adsorption energetics, thereby enabling concurrent activity-stability improvements. The resultant Ir@IrO x /m-Nb-TiO 2 anode achieves exceptional PEMWE performance with ultralow loading (0.27 mg Ir cm −2 ), requiring a low electrolysis voltage of 1.72 V to reach industrial current densities of 2 A cm −2 , coupled with unprecedented durability with <1.7% voltage decay over 3000 h. This interface design philosophy establishes a general paradigm for developing active and stable supported electrocatalysts for PEMWE and beyond.}, archive = {J_ANGEW}, author = {Jing Ni and Zhaoping Shi and Jingsen Bai and Mingrui Yu and Xiaohui Liu and Kai Li and Tao Gan and Jiong Li and Jianbing Zhu and Minhua Shao and Meiling Xiao and Changpeng Liu and Wei Xing}, doi = {10.1002/anie.202509985}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509985}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterointerface anchored ir with localized strong orbital coupling for durable proton exchange membrane water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Pyridine nitrogen decorated carbon support for high-performance seawater electrolyte-based Zinc–Air battery. ANGEW, 64(37), e202509911. (www)

  @article{ , abstract = {Developing high specific energy seawater electrolyte-based zinc–air batteries (SZABs) is crucial for marine energy supply systems. However, their widespread application is restricted by the slow oxygen reduction reaction (ORR) kinetics coupled with the poisoning of adsorbed Cl − in seawater electrolyte. Herein, we design a pyridinic nitrogen-modified carbon-supported Fe single-atom catalyst [Fe-SAC/NC(Py)] to achieve exceptional ORR performance in seawater electrolytes. The Fe-SAC/NC(Py) achieves a high onset potential ( E onset ) and halfwave potential ( E 1/2 ) of 1.174 and 0.907 V versus RHE, respectively, significantly outperforming the commercial 20% Pt/C (E onset : 0.972 V, E 1/2 : 0.848 V). Furthermore, the assembled SZABs demonstrates a peak power density of 204 mW cm −2 and a specific capacity of 800 mAh g −1 , surpassing most previously reported catalysts. In-situ characterizations and theoretical calculations reveal that the pyridinic nitrogen-modified carbon support in situ constructs a negatively charged interface during ORR process, effectively suppressing Cl − adsorption. Additionally, the atomic Fe sites coordinated with pyridinic nitrogen optimize the charge distribution of the active centers, lowering the adsorption energy of oxygen-containing intermediates and thereby enhancing ORR catalytic performance.}, archive = {J_ANGEW}, author = {Yurong Liu and Yousheng Zhu and Yuxin Zhang and Peng Rao and Jing Li and Lutong Shan and Boya Tang and Xiaodong Shi and Zhenye Kang and Xinlong Tian}, doi = {10.1002/anie.202509911}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509911}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pyridine nitrogen decorated carbon support for high-performance seawater electrolyte-based Zinc–Air battery}, volume = {64}, year = {2025}, }
• (2025). Ketenimine multicomponent strategy for multifaceted amidine functionalization of peptides on the solid phase. ANGEW, 64(37), e202509854. (www)

  @article{ , abstract = {The amidine group and its derivatives serve as proteolytically stable bioisosteres of the peptide bond, and their selective incorporation into peptides attributes significant chemical and biological features. This study introduces an efficient synthesis of amidine-containing peptides by a copper-catalyzed, solid-phase-compatible multicomponent reaction (MCR), leveraging ketenimine intermediates that are generated in situ. Through the reaction of sulfonyl azides with terminal alkynes and a wide variety of amines, we establish the robust on-resin synthesis of δ/ε-amidine amino acids, arginine isologues, fluorescently labeled peptides, drug-peptide hybrids, and PEGylated derivatives. This strategy notably supports a wide range of peptide modifications, including side chain alteration, amine functionalization, and peptide macrocyclization through both backbone and side chain groups, as well as incorporating aromatic scaffolds into the peptide backbone. The methodology demonstrates broad substrate tolerance, compatibility with peptide chemistry protocols, and access to complex motifs, including pharmacophores and imaging tags, all within a single reaction platform. Our results underscore the synthetic versatility and functional applicability of ketenimine-based MCRs for advanced peptide modification, expanding the chemical space of peptide medicinal chemistry and therapeutics.}, archive = {J_ANGEW}, author = {Supriya Mahadev Bodake and Udaya Kiran Marelli}, doi = {10.1002/anie.202509854}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509854}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ketenimine multicomponent strategy for multifaceted amidine functionalization of peptides on the solid phase}, volume = {64}, year = {2025}, }
• (2025). Spin-orbit effects in a thallium borohydride stabilized by coordination to Bis(diisopropylamino)Cyclopropenylidene (BAC). ANGEW, 64(37), e202509732. (www)

  @article{ , abstract = {Reaction of Tl(OTf) with 2 equiv of bis(diisopropylamino)cyclopropenylidene (BAC) in THF results in formation of [Tl(BAC) 2 (OTf)] ( 1 ) in moderate yields. Subsequent reaction of 1 with [K][H 2 -9-BBN] ([H 2 -9-BBN] − = dihydrido 9-boratabicyclo[3.3.1]nonane) in THF results in formation of [Tl(BAC)(μ-H 2 -9-BBN)] 2 ( 3 ), also in moderate yield. Complex 3 is the first reported thallium borohydride. We attribute its thermal stability to the strong donor ability of the BAC co-ligand. Both 1 and 3 exhibit trigonal pyramidal geometries about Tl + in the solid-state, indicative of the presence of stereochemically active lone pairs. The hydride environment in 3 is calculated to exhibit a 3.9 ppm downfield shift attributed to spin-orbit effects from the adjacent Tl center.}, archive = {J_ANGEW}, author = {Thien H. Nguyen and Xiaojuan Yu and Guang Wu and Jochen Autschbach and Trevor W. Hayton}, doi = {10.1002/anie.202509732}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509732}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spin-orbit effects in a thallium borohydride stabilized by coordination to Bis(diisopropylamino)Cyclopropenylidene (BAC)}, volume = {64}, year = {2025}, }
• (2025). Zwitterionic electrolyte additive for lithium-ion batteries: Ammonium alkyl sulfonate. ANGEW, 64(37), e202509673. (www)

  @article{ , abstract = {Electrolyte additive is an important component of lithium-ion batteries. At present, commercial film-forming additives can only work on either anode or cathode so as to increase the complexity and decrease the efficiency of the electrolyte. In this work, we designed and synthesized a novel zwitterionic 3-(triethylammonium)-propane-1-sulfonate (TEAPS) additive, which can adsorb on the surface of both graphite anode and LiCoO 2 cathode in propylene carbonate (PC) electrolyte. The kinetically and thermodynamically favorable film-forming reaction of TEAPS promotes the formation of a robust F/S/N-species domain interface, thereby enables greatly improved cycling performance. It is believed that the zwitterionic TEAPS will work as a novel versatile additive for high-performance LIBs.}, archive = {J_ANGEW}, author = {Ruize Sun and Jingyu Yang and Yongjin Fang and Zhongxue Chen and Faping Zhong and Yuliang Cao}, doi = {10.1002/anie.202509673}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509673}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zwitterionic electrolyte additive for lithium-ion batteries: Ammonium alkyl sulfonate}, volume = {64}, year = {2025}, }
• (2025). Copper(II)-photocatalyzed radical anellation of nitroalkanes with alkenes or alkynes for the synthesis of isoxazolines and isoxazoles. ANGEW, 64(37), e202509658. (www)

  @article{ , abstract = {The visible light-mediated copper(II)-catalyzed one-step synthesis of isoxazolines and isoxazoles from readily available ethyl nitroacetate or phenyl nitromethane is reported. The developed protocol eliminates the need for substrate preactivation or additives, and offers an extensive scope of activated and unactivated alkenes and alkynes as coupling partners. Key intermediates for this formal [3 + 2]-cycloaddition are α-nitro radicals generated via photoinduced single-electron oxidation of nitronates, contrasting the generation of such radicals via Cu(I)-photocatalysis by a reductive pathway, which shows a different reaction pattern in the coupling with alkenes.}, archive = {J_ANGEW}, author = {Sunaina Sardana and Aryaman Pattanaik and Julia Rehbein and Oliver Reiser}, doi = {10.1002/anie.202509658}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper(II)-photocatalyzed radical anellation of nitroalkanes with alkenes or alkynes for the synthesis of isoxazolines and isoxazoles}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of ε-lactams via Rh(I)-catalyzed C─C bond activation. ANGEW, 64(37), e202509640. (www)

  @article{ , abstract = {ε-Lactams are important structural motifs in medicinal chemistry, but a fully enantioselective synthesis without byproduct formation represents a challenge that has attracted significant research interest. Herein, we report an atom- and step-economic synthesis of chiral ε-lactams via Rh(I)-catalyzed enantioselective C─C bond activation of aminocyclopropanes. The catalytic C─C bond activation enables a directed generation of chiral rhodacyclobutanes that circumvents β-hydride decomposition. Subsequent enantioselective cycloaddition of the alkene unit and then fragmentation generates chiral ε-lactams. A range of enantioenriched ε-lactams have been obtained with excellent regio- and enantioselectivities, which can undergo several stereospecific transformations. Theoretical calculations are performed to reveal the reaction mechanism and the origin of enantioselectivity control.}, archive = {J_ANGEW}, author = {Shiyuan Sui and Hao Wu and Yuanyuan Guo and Gongming Chen and Junbiao Chang and Dachang Bai}, doi = {10.1002/anie.202509640}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of ε-lactams via Rh(I)-catalyzed C─C bond activation}, volume = {64}, year = {2025}, }
• (2025). Crystal facet-dependent photocatalytic hydrogen evolution from ultra-stable cu-Zr/Hf heterobimetallic Metal–Organic frameworks. ANGEW, 64(37), e202509572. (www)

  @article{ , abstract = {Solar-driven water splitting for hydrogen production over metal–organic frameworks (MOFs) is particularly attractive yet remains a challenge. Here, we report a series of ultra-stable heterobimetallic MOFs (M-BCA-M', M = Cu + , M′ = Zr 4+ or Hf 4+ ) for photocatalytic hydrogen production, in which, the Cu(I) species act as the active center, whereas Zr(IV)/Hf(IV) plays an essential role in stabilizing the framework. Uniform MOF crystals with distinct morphologies were obtained, showing a rare crystal facet-dependent photocatalytic behavior. The octahedral MOF crystals denoted as Cu-BCA-Hf-O with the exposure of only {101} and {011} facets exhibit a record-high hydrogen production rate (49825.71 µmol g −1 h −1 ) among pristine MOF photocatalysts. The exceptional performance of Cu-BCA-Hf-O can be primarily attributed to its superior photogenerated carrier transfer ability and abundant active sites exposed on the crystal surface. This study provides molecular-level insights into the coordination regulation and morphology control of MOFs for highly efficient photocatalysis, highlighting the promising future of pristine MOF photocatalysts.}, archive = {J_ANGEW}, author = {Hang Lei and Jieping Zhang and Zhiyuan Wu and Yangxingyu Ye and Zhijia Li and Yunfang Zhao and Lian Chen and Yongsheng Liu and Maochun Hong}, doi = {10.1002/anie.202509572}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystal facet-dependent photocatalytic hydrogen evolution from ultra-stable cu-Zr/Hf heterobimetallic Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). A photoregulated peptidase mimic. ANGEW, 64(37), e202509194. (www)

  @article{ , abstract = {Proteases and peptidases play crucial roles in numerous biological processes. These enzymes bind to protein substrates and hydrolyze peptide bonds, resulting in the cleavage of proteins and peptides into smaller fragments. This study reports on a small-molecule light activated peptidase (SLAP) enzyme mimic featuring a glucose-linked photoswitch-imidazole triad, where peptidase activity can be controlled by light by tuning the distance between the basic imidazole residue, the reaction center, and the sugar moiety, that provides a binding site for the substrate and also takes a role in stabilizing the transition state. The cis isomer exhibited a ∼300-fold increase in catalytic activity compared to its inactive trans counterpart with a model amide-substrate. Catalytic hydrolysis was studied with small molecules, FRET-based substrates, and large cellular proteins. The light-controlled peptidase activity opens new possibilities for protein degradation in biological systems.}, archive = {J_ANGEW}, author = {Monochura Saha and Palash Jana and Subhajit Bandyopadhyay}, doi = {10.1002/anie.202509194}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509194}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A photoregulated peptidase mimic}, volume = {64}, year = {2025}, }
• (2025). PCR-free site-directed mutagenesis on repetitive sequences using single-stranded DNA-assisted double-stranded DNA nicking by DNAzymes. ANGEW, 64(37), e202509127. (www)

  @article{ , abstract = {Site-directed mutagenesis (SDM) is a key driver for many biochemical investigations and biotechnological applications. Despite decades of development, it is still difficult to perform SDM on some sequences, including highly repetitive ones, because polymerase chain reaction (PCR) is often used as the most effective method for SDM, but results in complicated products with these sequences. To overcome this limitation, we report herein a PCR-free SDM method that uses DNA-cleaving DNAzymes. Since these DNAzymes lack the capability of cleaving double-stranded DNA, we employed single-stranded DNAs as assisting DNAs to open superhelical plasmids, allowing the DNA-cleaving DNAzymes to cleave the plasmid. Such a system, named single-stranded DNA-assisted double-stranded DNA nicking by DNAzymes (DANDA), expanded the substrate scope of DNAzymes to double-stranded, superhelical plasmids. We showed that DANDA is highly customizable and target-specific, which allows successful generation of mutations on a plasmid containing PCR-incompatible repetitive sequences. By using solely unmodified DNA oligos that are more cost-effective and easier to prepare than other systems that employ either PNA or restriction enzymes, this DANDA system further expands the applications of DNA-cleaving DNAzymes in synthetic biology for different biochemical and biotechnological applications.}, archive = {J_ANGEW}, author = {Mingkuan Lyu and Linggen Kong and Xiangli Shao and Yi Lu}, doi = {10.1002/anie.202509127}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509127}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PCR-free site-directed mutagenesis on repetitive sequences using single-stranded DNA-assisted double-stranded DNA nicking by DNAzymes}, volume = {64}, year = {2025}, }
• (2025). Carbon dots-induced hydrogen-bonding traps in RHO zeolite: Mechanistic insights and superior flue gas separation performance. ANGEW, 64(37), e202509087. (www)

  @article{ , abstract = {Zeolites stand out as promising materials for flue gas separation, however, it poses a significant challenge to conduct pore interior modifications to improve the separation performance. Herein, we present a novel strategy for constructing hydrogen-bonding traps in a small-pore RHO zeolite by embedding carbon dots (CDs), thereby to regulate pore microenvironment and enhance the separation ability of CO 2 /N 2 . The incorporation of CDs into the RHO zeolite is realized via a straightforward calcination process, which endows the zeolite with the defect sites rich in hydroxyl groups that easily form hydrogen bonds with CDs. Along with 1 H- 1 H DQ-SQ experiments, in situ FTIR and DFT calculations, the unique hydrogen-bonding traps are unraveled, which can selectively capture and concentrate CO 2 . As a result, the CDs-containing zeolite (R-500) showcases exceptional performance in terms of both CO 2 adsorption (90.40 cm 3 g −1 at 298K and 1 bar) and CO 2 /N 2 (15/85) separation (IAST selectivity of 1063.6). Strikingly, a superior CO 2 adsorption with a capacity of 42.9 cm 3 g −1 is achieved in the dynamic separation process (CO 2 /N 2 15/85). The facile synthesis and impressive separation performance of R-500 provides a promising solution for industrial scale CO 2 /N 2 separation in flue gas.}, archive = {J_ANGEW}, author = {Yining Yang and Yida Zhou and Siyu Zong and Shiyu Zhou and Jiyang Li}, doi = {10.1002/anie.202509087}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509087}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon dots-induced hydrogen-bonding traps in RHO zeolite: Mechanistic insights and superior flue gas separation performance}, volume = {64}, year = {2025}, }
• (2025). Chemoenzymatic synthesis and protein engineering enable efficient, scalable production of teleocidin derivatives. ANGEW, 64(37), e202509083. (www)

  @article{ , abstract = {Monoterpenoid indole alkaloids (MIAs), a class of bioactive natural products, are highly valued in drug development for their unique pharmacological activities. Teleocidins, known for activating protein kinase C (PKC), are particularly promising but challenging to synthesize due to their structural complexity. Traditional methods often rely on heavy metals and yield low amounts, while biosynthetic approaches face efficiency issues. Our study developed an efficient chemoenzymatic route to produce 13 teleocidin B compounds and derivatives at scale. To overcome enzymatic reaction bottlenecks, we engineered the critical enzyme TleB by fusing a reductase module to create a self-sufficient P450 system, boosting indolactam V production to 868.8 mg L −1 . Additionally, we established a dual-cell factory co-expressing engineered hMAT2A-TleD and TleB/TleC enzymes, enabling the first fully enzymatic synthesis of teleocidin B isomers with a total yield of 714.7 mg L −1 . Chemical modifications further expanded the library with five novel indolactam V and two teleocidin A1 derivatives. Fermentation confirmed the recombinant Escherichia coli system's scalability, producing 430 mg indolactam V, 170 mg teleocidin A1, and 300 mg teleocidin B isomers. This work not only establishes a sustainable platform for teleocidin synthesis but also addresses efficiency and scalability challenges in complex natural product synthesis, paving the way for practical applications of bioactive compounds.}, archive = {J_ANGEW}, author = {Shuo Zheng and Zixuan Yang and Xiang Long and Xinying Ge and Zhiqin Zhang and Yinyin Feng and Yangyizhuo Li and Bo Gu and Yan Long and Xuanliang Yang and Rui Xu and Heng Song}, doi = {10.1002/anie.202509083}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202509083}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemoenzymatic synthesis and protein engineering enable efficient, scalable production of teleocidin derivatives}, volume = {64}, year = {2025}, }
• (2025). Simultaneous modulation of mesoporosity and al siting for superior performance zeolite catalyst in ethylene dehydroaromatization to aromatics. ANGEW, 64(37), e202508909. (www)

  @article{ , abstract = {Porosity and Al siting are key levers for optimizing zeolite catalysts, yet they are often addressed independently due to the lack of effective integrated tuning strategies. Herein, we report an integrative methodology for preparing hierarchical zeolite (Z F ) with interconnected mesostructures and tunable Al siting, achieved via regioselective dissolution of Al-rich domains by presetting accessible and inaccessible zones within parent zeolite (Z P ). Remarkably, ∼60% of the framework channels’ Al atoms were selectively removed without impairing the channel intersections’ Al atoms. Despite a 39% reduction in Brønsted acid sites (BAS), Z F exhibits a 1.8-fold higher turnover frequency (TOF) than Z P during ethylene transformation at 973K, attributable to the introduction of mesoporosity. Notably, site-specific 31 P NMR analysis reveals that BAS located at channel intersections exhibits a TOF of 516 h −1 , which is 13 times higher than that of sites within the channels (40 h −1 ). The hierarchical zeolite also demonstrates superior durability and enhanced aromatic selectivity compared to Z P . These results highlight the synergistic benefits of simultaneously tuning porosity and Al siting, offering a new paradigm for the rational design of high-performance zeolite catalysts and providing deeper insights into the interplay between structure and function in zeolite-based catalysis.}, archive = {J_ANGEW}, author = {Yanfeng Shen and Zhengxing Qin and Antoine Beuque and Eddy Dib and Shunsuke Asahina and Natsuko Asano and Izabel Cristina Medeiros Costa and Ruizhe Zhang and Lijuan Wang and Jiani Xu and Hongjuan Zhao and Jiujiang Wang and Ludovic Pinard and Svetlana Mintova}, doi = {10.1002/anie.202508909}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508909}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous modulation of mesoporosity and al siting for superior performance zeolite catalyst in ethylene dehydroaromatization to aromatics}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of feglymycin using umpolung amide synthesis. ANGEW, 64(37), e202508819. (www)

  @article{ , abstract = {The preparation of peptidic molecules is a mainstay of synthesis, creating new tools that advance chemical biology, catalysis, and drug discovery. Despite the wide adoption of methods for amide synthesis based on electrophilic acyl transfer reactions, significant limitations remain that restrict access to chemical space and plague accessible peptides with imperfect conservation of stereochemical information. These problems persist in key applications (i.e., solid phase peptide synthesis) where reagent excess can be used to drive maximal yield. As a general tactic, however, use of excess coupling agents that are often hazardous is unsustainable. Here we report the synthesis of the antiviral tridecapeptide feglymycin where half of the amides are formed using umpolung amide synthesis (UmAS) to replace conventional amide synthesis. Reliance on UmAS further allowed the enantioselective synthesis of each noncanonical residue from an inexpensive aldehyde. As a result, the most process-intensive components were simplified to a chiral Brønsted acid organocatalyst and potassium iodide/urea·hydrogen peroxide (KI/UHP). This solution-phase total synthesis illustrates the harmonious, strategic application of complementary amide synthesis methods, and it serves as a touchstone for the green synthesis of peptides composed of noncanonical amino amides.}, archive = {J_ANGEW}, author = {Preston C. Gourville and Jade A. Bing and Rashanique D. Quarels and Sergey V. Tsukanov and Kenneth E. Schwieter and Kazuyuki Tokumaru and Amanda B. Stephens and Dawn M. Makley and Bo Shen and Abigail N. Smith and Jeffrey N. Johnston}, doi = {10.1002/anie.202508819}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508819}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of feglymycin using umpolung amide synthesis}, volume = {64}, year = {2025}, }
• (2025). Homoleptic and heteroleptic Polyoxotungstate–Organic cages for efficient photocatalytic hydrogen evolution. ANGEW, 64(37), e202508797. (www)

  @article{ , abstract = {Metal–organic cages with polyoxometalate (POM) clusters as nodes are an emerging frontier of coordination-driven self-assembly, but they have been limited to homoleptic cages, which are composed of only one type of organic ligands. We show here that, in the construction of POM–organic cages with Keggin-type {SiW 9 Ni 4 } cluster nodes, introducing a secondary ligand may change the self-assembly processes in two distinct ways: by coordination or as supramolecular templates. The use of a tetracarboxylate panel L C , in complementary to a bent dicarboxylate linker (L A or L B ), allows the integrative self-sorting to give heteroleptic coordination cages POM 8 L A/B 4 L C 4 ( 3 or 4 ) that are otherwise not accessible through either ligand alone. The aromatic L C can also alter the outcome of the self-assembly process by acting as a non-coordinating template, transforming a coordinatively frustrated, homoleptic cage POM 8 L D 6 ( 5 ) to POM 8 L D 5 ( 6 ). These octa-Keggin cages were all shown to be efficient molecular catalysts for visible-light-driven hydrogen production; for 4 , in particular, an apparent turnover number of 4910 was achieved in 5 h under minimally optimized conditions. Mechanistic studies confirmed the existence of both reductive and oxidative quenching processes, with the former being dominant.}, archive = {J_ANGEW}, author = {Wenjun Ruan and Yeqin Feng and Yuan Gao and Kentaro Yonesato and Linjie Lan and Ziteng Guo and Panchao Yin and Ming Wang and Kosuke Suzuki and Hongjin Lv and Xikui Fang}, doi = {10.1002/anie.202508797}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508797}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Homoleptic and heteroleptic Polyoxotungstate–Organic cages for efficient photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Molecular-level design of polymeric semiconductor nanomotors with multichannel sensitive 3D motion for microorganism inactivation. ANGEW, 64(37), e202508705. (www)

  @article{ , abstract = {The advancement of high-performance photocatalysts is crucial for the iteration of light-driven micro/nanomotors. However, most existing light-driven micro/nanomotors, which are typically fabricated from inorganic semiconductors, suffer from limited visible-light absorption and inadequate control over 3D motion. Polymeric semiconductors, as emerging photocatalytic materials, feature narrow bandgaps, tunable band structures, and the potential for rational molecular design to optimize activity. This study introduces phenolic resins as efficient semiconductor photocatalysts, establishing a novel platform for constructing light-driven nanomotors. Among them, the m -aminophenol-formaldehyde resin nanomotor, synthesized via hydrothermal methods, exhibits exceptional mobility due to its efficient photoelectric conversion and charge transfer behavior. Its outstanding photoelectrochemical properties originate from a benzoxazine-quinoid structure with a low HOMO–LUMO gap (1.90 eV). These nanomotors feature broad-spectrum light absorption and can respond to various external stimuli, including light intensity, wavelength, and H 2 O 2 concentration, enabling precise control over in-plane and vertical motion with adjustable speed and directionality. As a proof of concept, the nanomotors demonstrate superior photodynamic inactivation of Karenia mikimotoi under visible light exposure, surpassing TiO 2 nanoparticles in antimicrobial efficiency. This work explores the relationship between molecular structure, photocatalytic performance, and motion behavior, providing instructive insights for designing light-driven nanomotors with advanced motion manipulation.}, archive = {J_ANGEW}, author = {Tianyi Liu and Huannuo Tao and Qingdong Chai and Hang Shi and Ziqi Zheng and Zhenning Sun and Guoxing Zhang and Xiangjun Wang and Jixin Zhou and Abuduheiremu Awati and Qirui Liang and Yanjun He and Dazhang Zhu and Mingxian Liu and Yue Shi and Kang Liang and Jian Liu and Biao Kong}, doi = {10.1002/anie.202508705}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508705}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular-level design of polymeric semiconductor nanomotors with multichannel sensitive 3D motion for microorganism inactivation}, volume = {64}, year = {2025}, }
• (2025). Harnessing pyridinic n vacancy defect in microporous structures to induce the pre-adsorption of oxygen and boost oxygen reduction reaction kinetics. ANGEW, 64(37), e202508674. (www)

  @article{ , abstract = {Defect structures within the carbon matrix play a crucial role in enhancing the oxygen reduction reaction (ORR) activity of Fe single atom and nitrogen-doped catalysts (Fe-N-C SACs). However, overlooking the O 2 pre-adsorption process induced by defective structures hampers the precise identification of active sites and the investigation of the reaction mechanism in Fe-N-C SACs. Hence, we report a Fe SAC with abundant pyridinic N vacancy defects in microporous structures (Fe-N v -C SAC) and propose a synergistic effect between pyridinic N vacancy defects and O 2 molecules that promotes the kinetics of ORR. The developed Fe-N v -C SAC demonstrates exceptional ORR performance, exhibiting superior mass activity and turnover frequency compared to conventional Fe-N-C SACs. The in situ Fourier transform infrared spectroscopy (FTIR) and theoretical calculations indicate that pyridinic N vacancy defects in microporous structures facilitate pre-adsorption of O 2 molecules results in the d-band centers of central Fe atoms shifting away from the fermi level. This shift weakens the adsorption strength of *OH species, thereby facilitating the kinetic process of ORR. This work addresses a critical gap in the field of electrocatalysis by providing the experimental validation of pre-adsorption of O 2 molecules on Fe single-atom catalysts, a phenomenon previously only speculated through theoretical calculations.}, archive = {J_ANGEW}, author = {Binbin Jia and Xuan Xie and Jie Lin and Huiqing Wang and Pengfei Hu and Fengyi Wang and Xiaoyu Fan and Jinlong Zheng and Tianyi Ma and Liqun Ye}, doi = {10.1002/anie.202508674}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508674}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing pyridinic n vacancy defect in microporous structures to induce the pre-adsorption of oxygen and boost oxygen reduction reaction kinetics}, volume = {64}, year = {2025}, }
• (2025). Water-soluble molecular wires for membrane potential imaging. ANGEW, 64(37), e202508660. (www)

  @article{ , abstract = {Voltage-sensitive probes based on donor-acceptor dyads, whose fluorescence is modulated by photoinduced electron transfer (PET) in response to changes in membrane potential, are known as PET molecular wires. PET wires have been widely used in cultured cells; however, their applications in tissue-level imaging have been hampered by their inadequate aqueous solubility, necessitating pre-dissolution in organic solvents that potentially can cause toxic effects. Here we present the synthesis, electronic structure analysis, photophysical characterization, and initial demonstration of water-soluble amphiphilic molecular wires, consisting of a rosamine, as a fluorescent PET acceptor, and a PET donor consisting of a conjugated bridge terminated by dimethylaniline (DMA). The rosamine moiety is extended by several carboxylates or polyethylene glycol (PEG) groups, which render the probes highly water-soluble and facilitate labeling of phospholipid membranes, positioning molecules in proper orientation. The probes produced functional responses in electrically stimulated mouse cardiomyocytes and as well as in intact neurohypophysis, and in glucose-stimulated murine islets of Langerhans. The new molecular wires make up a useful addition to the toolkit of optical reporters for membrane potential imaging.}, archive = {J_ANGEW}, author = {Mirna El Khatib and Margret A. Fye and Keita Uchida and Ana L. Obaid and Thomas Troxler and Dylan Valente and Brian M. Salzberg and Benjamin Prosser and Irina N. Kaverina and Sergei A. Vinogradov}, doi = {10.1002/anie.202508660}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508660}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Water-soluble molecular wires for membrane potential imaging}, volume = {64}, year = {2025}, }
• (2025). Atomic Metal‒Nonmetal catalytic pair cooperatively drives efficient enzyme-mimetic catalysis. ANGEW, 64(37), e202508651. (www)

  @article{ , abstract = {Single-atom catalysts with maximum atom utilization and well-defined coordination environments are promising alternatives to natural enzymes. However, their catalytic performance in enzymatic reactions is intrinsically restricted by the scaling relations, which impose an inherent trade-off between substrate adsorption/activation and product desorption. Here we report atomically dispersed manganese‒sulfur (Mn─S) catalytic pairs with strong electronic coupling that integratively drive enzymatic catalysis, in which the S atom not only modulates the electronic structure of the adjacent Mn site to promote substrate adsorption and activation, but also functions as the secondary catalytic site for stabilizing oxygenated intermediates and facilitating product desorption. Consequently, this metal‒nonmetal dual-site cooperation enables simultaneous optimization of both adsorption/activation and desorption processes, leading to remarkably enhanced catalytic activity. As a potential application, the Mn─S catalytic pairs with coupled catalase-, peroxidase-, and oxidase-mimicking activities are successfully demonstrated for synergistic tumor catalytic therapy. This work establishes a paradigm for the rational design of highly efficient artificial enzymes through catalytic pair engineering.}, archive = {J_ANGEW}, author = {Zheye Zhang and Fuhua Li and Shibo Xi and Lewen Zheng and Xiaozhe Wang and Baojie Du and Xiao Chi and Zhongxin Chen and Hong Bin Yang and Lishuang Zhang and Dongsheng Li and Bin Liu and Liping Li and Peng Chen}, doi = {10.1002/anie.202508651}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic Metal‒Nonmetal catalytic pair cooperatively drives efficient enzyme-mimetic catalysis}, volume = {64}, year = {2025}, }
• (2025). “Strong assisting weak” effect for long-lived room temperature phosphorescence in Host–Guest-doped systems. ANGEW, 64(37), e202508587. (www)

  @article{ , abstract = {Organic room temperature phosphorescence (RTP) materials, with long lifetime, large Stokes shift, and high signal-to-noise ratio, have great potential in numerous fields. And now, the host–guest-doped systems have become an effective approach for facilitating RTP, regardless of the still unclear inherent mechanism. In this work, a series of host–guest-doped RTP materials were constructed, and based on experimental results, the “strong assisting weak” effect was proposed. That is, the host with strong spin-orbit coupling (SOC) effect can effectively enhance the phosphorescence of the guest with weak intersystem crossing (ISC), while maintaining the guest's relatively long lifetime. With 4-dimethylaminopyridine (DMAP) as the host and naphthalene (NL) as the guest, the long RTP lifetime of 1.79 s could be achieved, which is obviously longer than 0.5 s of NL@ polymethyl methacrylate (PMMA). Triplet–triplet energy transfer (TTET) process from the dark triplet excitons of DMAP to NL was found to play the key role in triggering RTP of NL. These findings deepen our understandings of RTP mechanisms and provide practical guidance for the creation of highly efficient and long-lived RTP materials.}, archive = {J_ANGEW}, author = {Kexin Li and Xingyue Qi and Fangting Li and Yujun Xie and Liyao Zhang and Zhen Li}, doi = {10.1002/anie.202508587}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508587}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Strong assisting weak” effect for long-lived room temperature phosphorescence in Host–Guest-doped systems}, volume = {64}, year = {2025}, }
• (2025). Exposure of au atom on au(111) in metal nanoclusters for pH-universal electrocatalysis. ANGEW, 64(37), e202508459. (www)

  @article{ , abstract = {The control of surface and interface structures in nanocatalysts is a promising strategy for enhancing catalytic performance, but significant challenges persist in achieving precisely designed active sites or environments on the surface/interface of fully protected metal nanoclusters. In this study, we report the construction of an exposed Au atom on Au(111) and the formation of a unique surface/interface environment on the Au 52 cluster via a cyclopentanethiol-etching strategy. Theoretical calculations and in situ attenuated total reflection infrared adsorption spectroscopy reveal that the exposed Au atom facilitates CO 2 activation, while the tailored surface/interface environment promotes the accumulation of strongly hydrogen-bonded water, which can be validated by the molecular dynamic simulation, thus enhancing proton transfer and suppressing hydrogen evolution reaction (HER). Notably, the surface/interface-modified Au 52 cluster showcases high activity, selectivity, and durability across pH-universal (acidic, neutral, and alkaline) electrolytes, providing new insights for designing high-performance electrocatalysts at atomic level.}, archive = {J_ANGEW}, author = {Yajie Guan and Xia Zhou and Qisheng Yan and Zhanyu Wang and Jie Yang and Qing Tang and Likai Wang and Nan Xia}, doi = {10.1002/anie.202508459}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exposure of au atom on au(111) in metal nanoclusters for pH-universal electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Bioelectrosynthesis of signaling molecules for selective modulation of cell signaling. ANGEW, 64(37), e202508192. (www)

  @article{ , abstract = {Bioelectrosynthesis holds great potential for studying and regulating biological systems through the in situ synthesis and delivery of cell signaling molecules with high spatiotemporal precision. Despite recent advancements, precise control over multiple signaling molecules within a single platform remains challenging. Here, we introduce a bioelectrosynthesis approach capable of selectively producing two types of signaling molecules from a single precursor. This system leverages multi-metal sulfide electrocatalysts inspired by denitrifying enzymes, which generate signaling molecules, nitric oxide (NO), and ammonia (NH 3 ) from nitrite ions. By controlling catalytic active sites, NO or NH 3 can be selectively produced under mild electric fields in physiologically relevant conditions. In situ product analyses and first-principles calculations reveal that NO intermediate binding affinity determines product selectivity. These electrocatalysts integrate seamlessly with biological systems, allowing precise, on-demand modulation of NO- or NH 3 -mediated signaling pathways in human cell lines. By combining electrochemical precision with selective cell control, this strategy may advance the study and regulation of biological systems.}, archive = {J_ANGEW}, author = {Myeongeun Lee and Jaewoong Lee and Yongha Kim and Changho Lee and Sang Yeon Oh and Jihan Kim and Jimin Park}, doi = {10.1002/anie.202508192}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202508192}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bioelectrosynthesis of signaling molecules for selective modulation of cell signaling}, volume = {64}, year = {2025}, }
• (2025). Discharge rate-driven Li2O2 growth exhibits unconventional morphology trends in solid-state li-o2 batteries. ANGEW, 64(37), e202507967. (www)

  @article{ , abstract = {Solid-state lithium oxygen batteries (LOBs) are known for their enhanced safety, higher electrochemical stability, and improved energy density compared to liquid-state LOBs. However, the investigation of solid-state LOBs is limited with little understanding of their discharge and charge processes. In this work, a polymer-based solid-state LOB is used to investigate the effect of discharge rate on lithium peroxide (Li 2 O 2 ) formation, the oxygen evolution reaction (OER), and cycle performance. Notably, we observe a counterintuitive trend: Li 2 O 2 particle size increases with increasing discharge current density, in contrast to liquid systems. This behavior arises from inherent space charge layers that restrict Li⁺ transport under high current, and spatially heterogeneous active sites at the solid electrolyte–cathode interface, directly evidenced by small angle X-ray scattering (SAXS), which govern nucleation accessibility and promote site-selective Li 2 O 2 growth. Furthermore, higher current densities improve ORR and OER efficiency but accelerate anode degradation, while lower currents promote side reactions. These opposing effects result in a trade-off that defines an optimal discharge rate (0.1 mA cm⁻ 2 ) for maximizing cycle life. This study provides a new mechanistic perspective on discharge-driven processes in solid-state LOBs and offers practical guidelines for performance optimization in future high-energy battery systems.}, archive = {J_ANGEW}, author = {Xiaozhou Huang and Matthew Li and Yanan Gao and Moon Gyu Park and Shoichi Matsuda and Khalil Amine}, doi = {10.1002/anie.202507967}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202507967}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Discharge rate-driven Li2O2 growth exhibits unconventional morphology trends in solid-state li-o2 batteries}, volume = {64}, year = {2025}, }
• (2025). Multiaxial aromatic-based photoferroelectric induced by synergistic intermolecular interactions for multidirectional self-powered X-ray detection. ANGEW, 64(37), e202507640. (www)

  @article{ , abstract = {Photoferroelectrics coupling spontaneous polarization and remarkable semiconductor attributes have emerged as promising candidates for self-powered X-ray detection. However, the effective construction of multiaxial aromatic photoferroelectrics for stable multidirectional self-powered X-ray detection remains a great blank. Herein, we report for the first time the successful design of a multiaxial aromatic-based photoferroelectric, (4Br2FBZ) 2 PbBr 4 (4Br2FBZ = 4-bromo-2-fluorobenzylammonium), through synergistic noncovalent interactions of hydrogen bonding and fluorine-π, which achieves a stable multidirectional self-powered X-ray detection. Notably, the aromatic cations rotate driven by synergistic molecular interactions to form a T-shaped stacking architecture, resembling interlocking puzzle pieces. This oriented arrangement generates electric dipoles, inducing four equivalent polarization directions, which endow (4Br2FBZ) 2 PbBr 4 with a large spontaneous polarization of 4.48 µC cm −2 and a high Curie temperature of 408 K. The combination of its biaxial nature and strong intermolecular interaction network, self-powered X-ray detectors assembled along two polar axes demonstrate high sensitivities (181.7 and 175.3 µC Gy −1 cm −2 ), and exceptional detection stability. Strikingly, the polycrystalline ferroelectric film also exhibits excellent self-powered X-ray detection behavior due to its biaxial ferroelectricity, indicating the potential for next-generation flexible and thin-film integrated devices.}, archive = {J_ANGEW}, author = {Lijun Xu and Zhenyue Wu and Huang Ye and Qianwen Guan and Hang Li and Chengshu Zhang and Chengmin Ji and Junhua Luo}, doi = {10.1002/anie.202507640}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202507640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiaxial aromatic-based photoferroelectric induced by synergistic intermolecular interactions for multidirectional self-powered X-ray detection}, volume = {64}, year = {2025}, }
• (2025). Enhancing oxygen transport in proton exchange membrane fuel cell through nanoconfined triple phase interface engineering. ANGEW, 64(37), e202507604. (www)

  @article{ , abstract = {In proton exchange membrane fuel cells (PEMFCs), ionomer aggregation on Pt/C catalysts leads to increased oxygen transport resistance of conventional catalyst layers. This behavior significantly influences oxygen transport in the microenvironment at the triple-phase interface of Pt/C catalysts. To address this challenge, triazine-based covalent organic frameworks (COFs) were incorporated into the cathode catalyst layer, so that their well-defined pore structure and proton eligible triazine sites interact with terminal sulfonate groups of the Nafion ionomer. This interaction regulates the triple-phase microenvironment, enhances Pt utilization, and establishes directed oxygen-enriched transport channels. Under low-platinum loading conditions (−0.05 mg Pt cm −2 ) in a H 2 ─O 2 PEMFC, the COF-modified system achieved a peak power density of 1.55 W cm −2 , 1.3 times of conventional PEMFCs, with a 38% reduction in local oxygen transport resistance. This work presents a new design principle for high-performance low-platinum PEMFCs, as a new approach to further advance their commercialization.}, archive = {J_ANGEW}, author = {Juejin Teng and Min Wang and Quanbin Dai and Yilin Wang and Enyang Sun and Mingbo Wu and Zhongtao Li}, doi = {10.1002/anie.202507604}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202507604}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing oxygen transport in proton exchange membrane fuel cell through nanoconfined triple phase interface engineering}, volume = {64}, year = {2025}, }
• (2025). Ni-bis(dithiolene) coordination enhanced dual-functional covalent organic frameworks for both cathodic zn2+ storage and anodic zinc deposition control in aqueous zn-ion batteries. ANGEW, 64(37), e202507352. (www)

  @article{ , abstract = {In response to the increasing demand for sustainable energy storage solutions, aqueous zinc-ion batteries (AZIBs) have garnered significant attention for their high safety, low cost, and environmental friendliness. However, two major challenges to battery stability persist: developing efficient cathode materials and addressing zinc dendrite formation. Here, we report a dual-functional covalent organic framework (COF), named Ni–DAPTO, designed to improve both Zn 2+ storage on the cathode and zinc deposition kinetics on the anode. The incorporation of Ni coordination centers achieves an expected low energy gap, enhancing the intrinsic conductivity, while selectively guiding uniform Zn 2+ deposition. As a result, the Ni–DAPTO cathode demonstrated superior cycling stability and rate performance, retaining a specific capacity of 127.0 and 119.7 mAh g −1 at 0.5 and 10.0 A g −1 , respectively after 10 000 cycles. Besides, when employed as artificial solid electrolyte interphase (SEI), Ni–DAPTO can improve zinc utilization and inhibit dendrite formation. The full AZIBs assembled with Ni–DAPTO cathodes and Ni–DAPTO modified Zn anodes deliver a discharge capacity of 100.9 mAh g −1 after 1000 cycles at a current density of 5.0 A g −1 . These findings suggest that multifunctional COFs hold great potential for advancing high-performance and long-lasting aqueous secondary batteries.}, archive = {J_ANGEW}, author = {Qianchuan Yu and Tianyu Shen and Si-Wen Ke and Kaiqiang Zhang and Xinmei Song and Jingjie Sun and Zuoao Wu and Miao Wang and Yongxin Yang and Zedong Zhang and Anqi Zhang and Zuoxiu Tie and Yichao Yan and Jing Ma and Jinglin Zuo and Zhong Jin}, doi = {10.1002/anie.202507352}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202507352}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ni-bis(dithiolene) coordination enhanced dual-functional covalent organic frameworks for both cathodic zn2+ storage and anodic zinc deposition control in aqueous zn-ion batteries}, volume = {64}, year = {2025}, }
• (2025). From spiropyran to a circadian-responsive photochromic supramolecular system for sustainable crop protection: Enhanced photostability, biofilm disintegration, and foliar adhesion. ANGEW, 64(37), e202507179. (www)

  @article{ , abstract = {Biofilms establish protective sanctuaries that shield resident bacteria, facilitating resistance. Despite extensive efforts, current chemicals for biofilm eradication remain insufficient, with the reliance on single-structure antimicrobials further exacerbating resistance. Photoisomerizable spiropyran derivatives reversibly transition between conformational states, alternately exerting antimicrobial activity against pathogens and potentially mitigating resistance. However, the biofilm-eradicating potential of spiropyran derivatives remains unverified, while their application is hindered by limited fatigue resistance, suboptimal foliar affinity, and reliance on UV-induced isomerization, all of which are incompatible with sustainable agriculture. Herein, we present a supramolecular strategy to fabricate SpA6 (MC)⊂CB[8], a self-assembled complex of the spiropyran derivative SpA6 and cucurbit[8]uril, offering day–night cycle isomerization, enhanced photostability, potent biofilm disruption, improved foliar adhesion, and high antibacterial activity. Notably, neither ambient light nor darkness attenuates its potency, enabling persistent antibacterial activity across diverse molecular configurations. In vivo studies demonstrate its superior dual protective/curative efficacy (54.73%/49.60%) at 200 µg mL −1 against bacterial leaf blight, surpassing thiazole copper (37.63%/33.58%) and bismerthiazol (31.20%/25.59%) without compromising safety, while extended indications reveal its enhanced efficacy (78.99%/63.50%) against citrus canker, outperforming thiazole copper (59.50%/41.42%). This work establishes a paradigm for developing light-responsive supramolecular agrochemicals that combine structural dynamism with enhanced functionality, offering sustainable solutions against plant pathogens.}, archive = {J_ANGEW}, author = {Lijun Fan and Kongjun Liu and Jinghan Yang and W. M. W. W. Kandegama and Peiyi Wang}, doi = {10.1002/anie.202507179}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202507179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From spiropyran to a circadian-responsive photochromic supramolecular system for sustainable crop protection: Enhanced photostability, biofilm disintegration, and foliar adhesion}, volume = {64}, year = {2025}, }
• (2025). Nondestructive patterning of upconverting and down-shifting luminescent nanoparticles for information encryption. ANGEW, 64(37), e202506972. (www)

  @article{ , abstract = {Patterning luminescent colloidal nanoparticles (NPs) at the micro- and nanometer scale is crucial for their integration into advanced solid-state optical, photonic, and electronic devices. However, it remains challenging to achieve high resolution and high fidelity in patterning chemically fragile luminescent NPs, while not sacrificing their structural integrity and/or optical properties. Here, we develop a rationally designed three-armed diazo crosslinker ( 3G ) for nondestructively patterning various chemically sensitive luminescent NPs with high resolution (down to nanoscale) and high fidelity. The key points of the 3G design include (i) shielding aliphatic C─H bonds, (ii) extending the distance between active sites, and (iii) introducing more crosslinkable moieties. Thanks to the low UV exposure dose (18 mJ cm −2 , in stark contrast to 200–500 mJ cm −2 for diazirine-based crosslinkers) required for sufficient crosslinking, mild photochemistry of 3G , and proper alignment of energy levels between 3G and NPs, the 3G -based patterning method can fully preserve the structural and photophysical properties of both upconverting NPs and perovskite quantum dots, as reflected by their unchanged emission peak/lifetime and high quantum yield retention (90%). Moreover, this method enables the fabrication of multi-layer structures for dual-mode anti-counterfeiting. This work broadens the scope for patterning inorganic NPs, thereby facilitating their potential applications in system-level devices.}, archive = {J_ANGEW}, author = {Liwei Dai and Siyu Yi and Zi-Han Chen and Xiancheng Zhang and Huibin He and Yazi Wang and Angang Dong and Fan Zhang and Xiangcheng Pan and Yutao Sang and Zhihong Nie}, doi = {10.1002/anie.202506972}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202506972}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nondestructive patterning of upconverting and down-shifting luminescent nanoparticles for information encryption}, volume = {64}, year = {2025}, }
• (2025). On-surface synthesis and characterization of cumulene-linked stone-wales polymers. ANGEW, 64(37), e202506803. (www)

  @article{ , abstract = {Structural, chemical, and extrinsic modifications of graphene-based nanostructures enable bandgap tuning, optoelectronics, spintronics, and quantum materials design. A well-known approach to modify their electronic properties involves introducing nonbenzenoid ring topologies in their ideal sp 2 -hybridized hexagonal lattice, such as azulene or Stone-Wales (SW) defects. However, despite the unique structural and electronic characteristics that these nonalternant defects induce, their systematic incorporation in graphene-based nanostructures remains challenging. Here, we demonstrate the on-surface synthesis of one-dimensional SW-based polymers linked through cumulene bonds on the Au(111) surface via thermal and visible-light-induced reactions of a tailored molecular precursor. Scanning tunneling and noncontact atomic force microscopies reveal the nonplanar structure of SW-based units within the polymer chain, while the chemical structure of the polymer has been verified by Raman spectroscopy in combination with theoretical modeling. Additionally, scanning tunneling spectroscopy measurements show an experimental bandgap of 1.8 eV, which significantly differs from its isostructural cumulene-bridged bisanthene analogs. Our results highlight the critical role of SW defects in the structural and electronic properties of carbon-based conjugated polymers, advancing their design with prospects in next-generation optoelectronic devices.}, archive = {J_ANGEW}, author = {Elena Pérez-Elvira and Fupeng Wu and Jeong Ha Hwang and Ji Ma and Lucia Palomino-Ruiz and Sofia Canola and Ana Barragán and Koen Lauwaet and José M. Gallego and Rodolfo Miranda and Mickael L. Perrin and David Écija and Aurelio Gallardo and Gabriela Borin Barin and Xinliang Feng and José I. Urgel}, doi = {10.1002/anie.202506803}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202506803}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-surface synthesis and characterization of cumulene-linked stone-wales polymers}, volume = {64}, year = {2025}, }
• (2025). Predicting A-element substitution and MXene formation in reactions between MAX phases and molten salts. ANGEW, 64(37), e202506622. (www)

  @article{ , abstract = {Selective etching has emerged as a key method for synthesizing 2D materials, with the conversion of MAX phases to MXenes being by far the most widely studied and reported example. While traditional methods rely on etching in primarily acidic aqueous media, molten salts offer an intriguing alternative. However, the current understanding of MAX phase reactivity in molten salts is limited, restricting our ability to predict reaction outcomes. In this study, we present a computational framework that uses process-specific phase diagrams to model A-element substitution and MXene formation, as well as competing side reactions. Applying this approach to Ti 3 AlC 2 , V 2 AlC, and Ti 2 AlN in ZnCl 2 molten salt, we reveal distinct reaction behaviors despite identical redox potentials—defined here by the Al-to-Zn exchange—of key processes. Our findings underscore the limitations of predicting reactions based solely on redox potentials and show that our model can capture key trends in MXene synthesis. Beyond MXenes, our methodology lays the groundwork for identifying new 2D materials accessible through molten salt etching.}, archive = {J_ANGEW}, author = {Jonas Björk and Johanna Rosen}, doi = {10.1002/anie.202506622}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202506622}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Predicting A-element substitution and MXene formation in reactions between MAX phases and molten salts}, volume = {64}, year = {2025}, }
• (2025). Electron spin resonance at the single-molecule scale. ANGEW, 64(37), e202506539. (www)

  @article{ , abstract = {Electron spin resonance (ESR) is a widely employed spectroscopic technique for studying systems with unpaired electron spins, such as molecular radicals. Typically, many billions of spins are required to get a detectable ESR signal, which is subject to extensive ensemble averaging. Downscaling ESR to a single molecule allows studying the signatures of each individual molecule separately, applicable to biomolecules in their native environment, for example. Single-molecule ESR offers several novel research avenues, such as in quantum sensing with a single molecule. Over the last decades, four different single-molecule ESR approaches have been developed, which rely on either optically detected magnetic resonance or scanning-probe microscopy. An introduction into these four approaches including their deployment in pioneering works will be provided.}, archive = {J_ANGEW}, author = {Lisanne Sellies and Jascha Repp}, doi = {10.1002/anie.202506539}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202506539}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron spin resonance at the single-molecule scale}, volume = {64}, year = {2025}, }
• (2025). Single-atom ligation of four different alcohols at one silicon center: Methodology development and proof of concept. ANGEW, 64(37), e202506444. (www)

  @article{ , abstract = {While critical and indispensable in diversified areas, organosilicon compounds are not naturally occurring and all rely on chemical synthesis. The de novo synthesis of them via quadruple substitutions of tetrachlorosilane was one of the most straightforward and common practices but confronted over-substitution challenges for heteroleptic silanes, especially the ones with four different substituents. Although selective and iterative substitutions at silicon have achieved notable achievements, methods for fully heteroleptic tetraalkoxysilanes are still lacking. Herein, we established the key dephenylative etherification reaction coupling phenylsilanes and alcohols to alkoxysilanes and then developed triphenylchlorosilane (Ph 3 SiCl) as the surrogate to tetrachlorosilane for the iterative and controllable ligation of four different alcohols to one silicon center as fully heteroleptic tetraalkoxysilanes. Mechanistic studies revealed the unusual transformations of Wheland intermediates into both silicon cations and silylated phenylhalonium ions in low and comparable activation barriers.}, archive = {J_ANGEW}, author = {Chao Wang and Xin Xu and Xinyu Zhang and Haifeng Lin and Jie Wang and Pathan Mosim Amin and Youliang Wang}, doi = {10.1002/anie.202506444}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202506444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-atom ligation of four different alcohols at one silicon center: Methodology development and proof of concept}, volume = {64}, year = {2025}, }
• (2025). Complex multistate photophysics of a rhodanine photoswitch. ANGEW, 64(37), e202506137. (www)

  @article{ , abstract = {Development of new and improved photoswitches for molecular photonics and photo-pharmaceutics is an increasingly important research objective. Recently a promising family of photoswitches based on the rhodanine motif was described. Here, the photophysics of a typical example are investigated by ultrafast UV and IR spectroscopy and quantum chemical calculations. Remarkably, the photophysics are very different to and more complex than those of closely related monomethine photoswitches, which relax by ultrafast internal conversion to the electronic ground state. In the rhodanine photoswitch, the allowed Franck–Condon excited state also relaxes on a sub-picosecond timescale, but the ground state is repopulated only after several hundred picoseconds. Instead, the Franck–Condon state relaxes through (at least) two intermediate states. These states are characterized by transient spectroscopy, and the reaction pathway is modeled by quantum chemical calculations. Comparison of calculated and measured IR data suggests that a triplet mediated isomerization pathway is responsible for the slow excited state dynamics. The triplet state is rapidly populated via coupling of a nearly degenerate nπ * state populated by ultrafast internal conversion from the bright ππ * state. This unexpected isomerization pathway has important implications for the synthesis, analysis, and application of rhodanine photoswitches.}, archive = {J_ANGEW}, author = {Anam Fatima and Pratip Chakraborty and Xinyue Xu and Garth A. Jones and Isabelle Chambrier and Giorgia Logan and Andrew N. Cammidge and Trevor Smith and Christopher R. Hall and Stephen R. Meech}, doi = {10.1002/anie.202506137}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202506137}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Complex multistate photophysics of a rhodanine photoswitch}, volume = {64}, year = {2025}, }
• (2025). Understanding optical properties and electronic structures of high-entropy alloyed perovskite nanocrystals. ANGEW, 64(37), e202505890. (www)

  @article{ , abstract = {High-entropy alloying (HEA) has emerged as a prominent strategy to modulate physiochemical properties of nanomaterials. Nevertheless, this approach is underexplored in luminescent semiconductor nanocrystals (NCs) due to the lack of understanding into the HEA-induced electronic effect and photophysical behaviors. Herein, harnessing the defect tolerance of metal halide perovskite NCs, we systematically synthesized and characterized high-entropy halide perovskite (HEP) NCs containing multiple B-site elements (Pb 2+ , Sr 2 ⁺, Ca 2 ⁺, Cd 2 ⁺, and Mg 2 ⁺). High-resolution transmission electron microscopy, transient photoluminescence and absorption spectroscopy, X-ray photoemission spectroscopy, and density functional theory simulations are employed to unravel the evolution of electronic structures with respect to the alloying degree and link them to the spectral signatures and photostability. Counterintuitively, although the HEP NCs exhibit lateral sizes smaller than the Bohr diameter of CsPbBr 3 NCs (∼7 nm), HEA reduces the band dispersion and broadens the conduction band, thereby vanishing the excitonic feature by forming near band-edge shallow states. We show that these HEA-induced shallow states foster rapid radiative recombination and improve photostability, accompanied by a significantly reduced lead content by up to 70%. These findings pioneer the understanding of the correlation between HEA-induced electronic effect and photophysical properties, highlighting the versatility of HEA for band structure engineering and stabilization of metal halide perovskites NCs.}, archive = {J_ANGEW}, author = {Yung-Tai Chiang and Sunil B. Shivarudraiah and Alexander Wieczorek and Khoong Hong Khoo and Zhidong Leong and Jia Wei Melvin Lim and Zengshan Xing and Sudhir Kumar and Simon F. Solari and Yen-Ting Li and Yu-Cheng Chiu and Tze Chien Sum and Yun Liu and Sebastian Siol and Chih-Jen Shih}, doi = {10.1002/anie.202505890}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202505890}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Understanding optical properties and electronic structures of high-entropy alloyed perovskite nanocrystals}, volume = {64}, year = {2025}, }
• (2025). Ionic liquid-confined covalent-organic framework pores as nanoreactors for CO2 photoconversion. ANGEW, 64(37), e202505886. (www)

  @article{ , abstract = {The topological nanopores of covalent organic frameworks (COFs) show promise as spatially confined nanoreactors for solar CO 2 photoconversion. However, simultaneously increasing the electron density, improving the electron transfer, CO 2 capture, and catalytic efficiency within nanopores remains a challenge for optimizing the performance of such nanoreactors. Here, micro- and mesoporous triazine-COFs were in situ grown on amino-modified BiVO 4 nanosheets (BVO), respectively, obtaining two-dimensional heterojunctions. A highly active ionic liquid (IL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][NTf 2 ]) was subsequently confined within COF nanopores. Adopting IL-confined COF mesopore-nanoreactors, the best nanocomposite enables a 38-fold photoactivity enhancement compared to BVO and 100% selectivity towards CO and CH 4 in pure water under UV-vis light irradiation, resulting in the record apparent quantum yield of 12.7% in visible region. Such performance is due to increased electron density inside mesopores via Z-scheme charge separation between BVO and COF, and the nanoconfinement effects of mesopores for IL, leading to i) facilitated directed electron transfer from COF to IL via multi-hydrogen bonds between the triazine acceptors and [EMIM] + cations, ii) promoted CO 2 capture by redistribution of IL ions, and iii) easy activation of CO 2 molecules owing to shortened distance to adjacent [EMIM] + cations as catalytic sites and reduced relative orientation angle.}, archive = {J_ANGEW}, author = {Haochun Yin and Houhou Huang and Linlu Bai and Zhongyu Liu and Xudong Yan and Rui Sun and Zhijun Li and Fuquan Bai and Enqi Chen and Lunqiao Xiong and Junwang Tang and Liqiang Jing}, doi = {10.1002/anie.202505886}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202505886}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ionic liquid-confined covalent-organic framework pores as nanoreactors for CO2 photoconversion}, volume = {64}, year = {2025}, }
• (2025). Directional depolymerization of poly(ε-caprolactone) with high monomer selectivity. ANGEW, 64(37), e202504819. (www)

  @article{ , abstract = {Chemical recycling to monomer (CRM) is the most attractive method for achieving the closed-loop usage of polymers, in which polymers are recycled back to their starting monomers and then used to produce new polymers without loss of the virgin material properties. However, during the CRM process, the depolymerized products are usually accompanied by the formation of byproducts (e.g., cyclic oligomers) in addition to monomers. Therefore, the directional depolymerization to monomer through catalyst design is significant. Herein, we report the directional depolymerization of poly(ε-caprolactone) (PCL) to ε-caprolactone (ε-CL) under solution conditions through innovative design of catalyst structure. The (BisSalen)Al catalysts, featuring a confined cavity, demonstrated exceptional performance, enabling highly selective depolymerization of PCL with excellent monomer selectivity (>99%) and yield (93%). The mechanism of selective depolymerization was further investigated in detail through controlled NMR experiments and density functional theory (DFT) calculations. This work reveals the correlation between catalyst structure and depolymerization selectivity, providing theoretical guidance for the design of directional depolymerization catalysts.}, archive = {J_ANGEW}, author = {Rulin Yang and Wei Wei and Guangqiang Xu and Xuanhua Guo and Qinggang Wang}, doi = {10.1002/anie.202504819}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202504819}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Directional depolymerization of poly(ε-caprolactone) with high monomer selectivity}, volume = {64}, year = {2025}, }
• (2025). Hydroxyl spillover activated from the strongly coupled Ru@Mn3O4 heterostructure to promote alkaline hydrogen evolution. ANGEW, 64(37), e202504667. (www)

  @article{ , abstract = {Alkaline hydrogen evolution reaction (HER) has great potential in practical hydrogen production. However, constructing an excellent catalyst with advantages of both superior water dissociation ability and easy OH * desorption remains urgently needed and yet challenging for the alkaline HER. Herein, superior water dissociation process, facile OH * desorption, and optimized H adsorption are realized on a strongly coupled heterostructure of Ru@Mn 3 O 4 , in which Ru clusters are decorated on Mn 3 O 4 via Ru─O─Mn bonds. The highly oxophilic Mn 3 O 4 facilitates the water dissociation, whereas the formed heterointerface can efficiently desorb OH * via hydroxyl spillover effect and optimize H adsorption. Consequently, the Ru@Mn 3 O 4 presents remarkable HER performance with a low overpotential of 17 mV at 10 mA cm −2 and Tafel slope of 30 mV dec −1 , surpassing recently reported Ru-based catalysts and commercial Pt/C. More importantly, the mass activity (MA) and turnover frequency (TOF) of the Ru@Mn 3 O 4 increase about 11- and 8-fold, respectively, compared to Pt/C at 100 mV in 1.0 M KOH. This study provides a new strategy for designing high-performance HER catalysts and enhancing the catalytic performance through hydroxyl spillover effect and sheds a light on understanding the HER mechanism.}, archive = {J_ANGEW}, author = {Changyi Xu and Huizhen Yu and Huamei Huang and Sha Li and Yinghuan Cao and Wenwen Peng and Yuting Li and Huijie Ke and Shiyu Xu and Huanxiong Mo and Can Wu and Hongyu Wang and Youlin Zhang and Xiaokun Li and Wei Chen}, doi = {10.1002/anie.202504667}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202504667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydroxyl spillover activated from the strongly coupled Ru@Mn3O4 heterostructure to promote alkaline hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Small molecule promoters of endogenous lipid droplet accumulation drive lysophagy. ANGEW, 64(37), e202504595. (www)

  @article{ , abstract = {Lipid droplets (LDs) are central in regulating metabolism in stress-induced conditions, including one triggered by nutrient deprivation. Genetic manipulation of the lipid metabolic network or supplementation of a high-fat diet/oleic acid (OA) are the traditional routes for voluntarily triggering LD formation in cells and animals to study the role of LDs in disease biology. We developed a new screening platform for identifying small molecule-based LD inducers, which identified linoleic acid (LOA, diunsaturated fatty acid) as a better tool than OA (monounsaturated fatty acid) in promoting LD formation in cells. Subsequent screening and validation discovered a novel heterocyclic compound and respective iron complex for promoting a rapid organization of endogenous lipids into droplets by mimicking desaturase function and modulating oxidative lipid metabolism. Notably, our mass spectral lipidomics analysis presented the overproduction of phosphatidylcholines and small triglycerides (TG), a hallmark of LDs. We uncovered that the abrupt levels of LD formation induced by our molecules promoted a unique cell death mechanism, lysophagy in cancer cells, to prevent their proliferation, movement, and colonization. Collectively, our work introduces new small molecules as powerful tools for reliably promoting LD accumulation in cells, a promising tool for studying the role in health and disease.}, archive = {J_ANGEW}, author = {Sai Kumari Vechalapu and Santhosh Duraisamy and Sathyapriya Senthil and Rakesh Kumar and Deepa Ajnar and Apparao Draksharapu and Suresh Kumar and Dharmaraja Allimuthu}, doi = {10.1002/anie.202504595}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202504595}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Small molecule promoters of endogenous lipid droplet accumulation drive lysophagy}, volume = {64}, year = {2025}, }
• (2025). Efficient hydrogen sulfide separation from carbon dioxide achieved by carbonyl-functionalized ionic liquids for natural gas upgrading. ANGEW, 64(37), e202504337. (www)

  @article{ , abstract = {Natural gas upgrading requires efficient separation of H 2 S from CO 2 , another acidic impurity, to enhance gas utilization efficiency and enable resource recovery from waste streams. While significant advancements have been achieved in separating H 2 S from CH 4 , the selective removal of H 2 S from CO 2 remains a formidable challenge due to their similar physicochemical properties. Herein, we report a breakthrough strategy utilizing reversible nucleophilic addition reaction between carbonyl group and H 2 S, departing from conventional acid-base interaction-based liquid-phase capture processes. Through comprehensive characterization using nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectroscopy, we confirmed the formation of nucleophilic addition products between the designed carbonyl-functionalized ionic liquids (ILs) and H 2 S. Dispersion-corrected DFT calculations revealed that the nucleophilic addition products facilitate secondary H 2 S capture through two distinct approaches: 1) conformational matching and 2) dissociation of H 2 S into [HS]⁻ species. The unique cascade H 2 S sorption mechanism demonstrates exceptional affinity for H 2 S, endowing the [6ca]-derived ILs with unprecedented high H 2 S capacities and record-breaking H 2 S/CO 2 selectivities (67–89 at 1.0 bar and 229–319 at 0.1 bar), surpassing previously reported values. Combined with energy-efficient regeneration cycles, these findings establish a new paradigm for H 2 S/CO 2 separation with significant potential for natural gas valorization.}, archive = {J_ANGEW}, author = {Mingzhen Shi and Guoao Li and Hangzhi Wu and Hailong Ning and Hongchao Lan and Xiaomin Zhang and Shuhua Li and Youting Wu}, doi = {10.1002/anie.202504337}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202504337}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient hydrogen sulfide separation from carbon dioxide achieved by carbonyl-functionalized ionic liquids for natural gas upgrading}, volume = {64}, year = {2025}, }
• (2025). Visual β-sheet-to-β-turn transition in luminescent polymeric vesicles for color-reporting drug delivery. ANGEW, 64(37), e202503875. (www)

  @article{ , abstract = {The secondary structures of polymers significantly influence their properties; however, understanding and modulating polymer conformations remain substantial challenges. Particularly, the β-turn conformation, which is prevalent in proteins, has not been reported in synthetic polymers due to its unclear formation mechanism and extremely poor stability. Additionally, there is a lack of visualization techniques to track conformational and functional transitions in polymers. Here, we designed and synthesized a novel tetraphenylethylene (TPE)-decorated poly(L-cysteine) derivative. Utilizing thioether oxidation as the driving force and strong aromatic-aromatic interactions between TPE molecules as stabilizing mechanism, we reported for the first time a conformational transition from β-sheet to β-turn in polymers. This transition not only significantly enhances fluorescence intensity but also induces chirality and circularly polarized light (CPL) of TPE, providing a new dual-modal approach to real-time monitoring of conformational changes of polymer chains. Furthermore, the conformational transition can trigger specific drug release, with the release process visualized and quantitatively analyzed through fluorescent colors. Such conformation-mediated structural and functional transformations hold significant potential for specific drug delivery and theragnosis of diseases such as cancer.}, archive = {J_ANGEW}, author = {Zifen Li and Yang Liu and Yiwei Wang and Yi Zheng and Chuan Peng and Zuojie Wang and Yeqiang Zhou and Xiaohan Dong and Mingming Ding}, doi = {10.1002/anie.202503875}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202503875}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visual β-sheet-to-β-turn transition in luminescent polymeric vesicles for color-reporting drug delivery}, volume = {64}, year = {2025}, }
• (2025). Atorvastatin-loaded mineralized vaccine reprograms endosomal trafficking to amplify STING-driven cancer immunotherapy. ANGEW, 64(37), e202503749. (www)

  @article{ , abstract = {Dendritic cell (DC)-targeted nanovaccines offer great promise for cancer immunotherapy but are severely limited by premature lysosomal degradation of antigens, which reduces cross-presentation efficacy. Here, we report a facile yet effective biomineralization strategy to construct nanovaccine (OVA-ATV@MnO₂) that co-delivers ovalbumin (OVA) and atorvastatin (ATV) within MnO₂ matrix. The ATV-mediated nanovaccine reprograms endosomal trafficking by inhibiting the mevalonate (MVA) pathway, thereby delaying endosomal maturation and preventing antigen diversion to degradative lysosomes. This intervention significantly enhances antigen preservation and MHC-I presentation in DCs. Simultaneously, the MnO₂ framework not only stabilizes the vaccine nanostructure but also releases Mn 2 ⁺ ions as an adjuvant to potently activate the cGAS-STING pathway, amplifying DC maturation and antitumor T-cell priming. In vivo studies demonstrate that the nanovaccine induces robust tumor regression, suppresses metastasis, and establishes durable prophylactic immunity. By synergistically rewiring intracellular antigen trafficking and amplifying STING-mediated immune activation, this mineralized vaccine platform provides a transformative strategy for precise cancer immunotherapy.}, archive = {J_ANGEW}, author = {Yuhan Yang and Wei Long and Xiangyu Pei and Shangfei Li and Bowen Fu and Hao Zhai and Xiaoyi Zhang and Ying Wan and Yayun Peng and Ting Cai}, doi = {10.1002/anie.202503749}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202503749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atorvastatin-loaded mineralized vaccine reprograms endosomal trafficking to amplify STING-driven cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Glycoconjugated metallohelices eliminate cancer stem-like cells via modulating G-quadruplex surrounding transcriptional start site of sox2 gene. ANGEW, 64(37), e202503488. (www)

  @article{ , abstract = {As an important pluripotency transcription factor, Sox2 plays key roles in the stemness maintenance of cancer stem-like cells (CSCs). Here, we found that a highly conserved G-rich region surrounding transcriptional start sites (TSSs) of Sox2 gene can form G-quadruplex (Sox2G4) both in vitro and in cells. More intriguingly, the glycoconjugated triplex metallohelice [Fe 2 L Δ-f 3 ] 4+ (Δ-f) can enantioselectively stabilize Sox2G4. Sox2G4 stabilization induced by [Fe 2 L Δ-f 3 ] 4+ (Δ-f) rather than Λ-f results in inhibition of Sox2 expression both in mRNA and protein levels in breast CSCs and decreases the cell viability and stemness of breast CSCs. These results indicate that [Fe 2 L Δ-f 3 ] 4+ (Δ-f) has the enantioselectivity even in living cells. In vivo studies further demonstrate that Δ-f can reduce tumor initiation of breast CSCs. To our knowledge, this is the first report that targeting G-quadruplexes of pluripotency genes can regulate the fates of CSCs. Our work provides a new way to target CSC gene and eradicate cancer stem cells.}, archive = {J_ANGEW}, author = {Hongshuang Qin and Jie Yang and Tingting Cui and Hualong Song and Miles Postings and Peter Scott and Chunyu Wang and Chuanqi Zhao and Jinsong Ren and Xiaogang Qu}, doi = {10.1002/anie.202503488}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202503488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Glycoconjugated metallohelices eliminate cancer stem-like cells via modulating G-quadruplex surrounding transcriptional start site of sox2 gene}, volume = {64}, year = {2025}, }
• (2025). Stable yet strongly lewis-acidic anions enabling cooperative catalysis with cationic transition-metal complexes. ANGEW, 64(37), e202503322. (www)

  @article{ , abstract = {Ionic transition-metal complexes play a crucial role as catalysts in organic transformations. Their counteranions often stand aside from the catalytic cycle or occasionally participate in the catalytic cycle as a Brønsted base due to their nucleophilic character. Herein, we developed a stable yet Lewis-acidic anion, BBcat , based on tetrakis(pentafluorophenyl)borate and featuring Lewis-acidic catechol borane moieties and applied it to transition-metal catalysis to recognize Lewis-basic substrates. Upon admixture with Bu 4 N – BBcat , 31 P NMR chemical shift of O═PEt 3 significantly lower-shifted, implying the strong Lewis acidity of BBcat despite being an anion. In an Ir complex supported by a bidentate phosphine ligand, BBcat resides in the second coordination sphere as a noncoordinating counteranion. Ir/PHOX-BBcat exhibited an 8.2-fold higher reaction rate than Ir/PHOX-BArF consisting of the non-coordinating anion in the hydrogen isotope exchange of acetophenone derivatives bearing additional Lewis-basic functionalities. The acceleration effect depends on the steric hindrance and basicity of the additional Lewis-basic sites, located at remote positions to the C─H bond to be deuterated. These results clearly indicate that the interaction of BBcat with the Lewis-basic sites plays a crucial role, facilitating cooperative catalysis of the cationic transition-metal center and the counteranion.}, archive = {J_ANGEW}, author = {Ryo Mandai and Takanori Iwasaki and Kyoko Nozaki}, doi = {10.1002/anie.202503322}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202503322}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable yet strongly lewis-acidic anions enabling cooperative catalysis with cationic transition-metal complexes}, volume = {64}, year = {2025}, }
• (2025). A modular platform for enhanced drug delivery to glioblastoma using targeted multidomain protein assemblies. ANGEW, 64(37), e202503085. (www)

  @article{ , abstract = {Protein-based nanocarriers bear highly desirable properties such as biodegradability and the ability to facilitate passage through biological barriers such as the blood–brain-barrier. Using modular protein engineering, we develop a strategy for iteratively improving the delivery efficacy of hydrophobic small molecules for the treatment of glioblastoma multiforme (GBM). By increasing the multiplicity m of the coiled-coil and RGD peptide targeting regions from 1 to 2, we can increase both the hydrodynamic micellar size and drug loading capacity of the targeted multidomain protein assembly (TMPA) relative to its predecessor thermoresponsive assembled protein (TRAP). An upper limit of m is likely determined by steric interactions. TMPA shows a 1.7-fold increase in doxorubicin (Dox) encapsulation compared to TRAP and demonstrates a 1.3-fold improvement in uptake by U87 human GBM cells. Near-infrared (NIR) dye-labelled TMPA (NIR-TMPA) is intravenously administered to mice orthotopically implanted with GBM cells and to control mice. Pharmacokinetic analysis using a 2-compartment pharmacokinetic model reveals a significantly prolonged distribution-phase (short-phase) half-life in tumor-bearing mice compared to control, while the elimination-phase (slow-phase) half-life remains comparable between groups. This suggests altered early-phase kinetics likely due to tumor-associated sequestration or retention. The resulting increased area under the concentration-time curve (AUC) in tumor-bearing mice supports enhanced accumulation or slower clearance. Ex vivo fluorescence imaging of organs and 3D reconstructions of whole mouse heads further corroboratesa preferential localization of NIR-TMPA in tumor regions. These findings highlight the potential of TMPA and its future derivatives for targeted GBM therapy.}, archive = {J_ANGEW}, author = {Andrew L. Wang and Aparajita Bhattacharya and Frances Lee and Orin Mishkit and Lucas Morales and James A. Tranos and Heather Mao and Neha Rahman and Joshua D. Frenster and Niklas Ravn-Boess and Naomi Crook and Youssef Z. Wadghiri and Dimitris G. Placantonakis and Jin Kim Montclare}, doi = {10.1002/anie.202503085}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202503085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A modular platform for enhanced drug delivery to glioblastoma using targeted multidomain protein assemblies}, volume = {64}, year = {2025}, }
• (2025). Sonoelectric nanonet-activated extracellular electron transfer for wireless non-genetic stimulation of pancreatic β cells. ANGEW, 64(37), e202502780. (www)

  @article{ , abstract = {Engineered cell-based therapy is an emerging approach for treating intractable diseases, in which the remote control of cellular behavior necessitates robust physical input-sensing-response systems. Nanomaterials represent promising tools to enable wireless remote control of cells. To achieve this, the precise anchoring of nanomaterials to target cells is crucial for nanomaterial-engineered cells to prevent undesired effects such as endocytosis and diffusion. Herein, we describe a general cell engineering strategy using nanomaterials to achieve remote-controlled and sustained insulin release from the engineered pancreatic β cells. The prepared nanocomposite, termed TCN, is composed of defect-rich titanium oxide quantum dots with ultrasound-electric conversion effect and fibrous carbon substrate. In vitro experiments demonstrate that the TCN enables cell surface engineering through carbon substrate adsorption onto pancreatic β cells without chemical modification, while the TiO x quantum dots of TCN enable effective ultrasound-responsive electrical stimulation to activate insulin release from β cells. Furthermore, we demonstrate that the subcutaneous implantation of TCN-engineered β cell complexes in type 1 and type 2 diabetic mice enables the restoration of normoglycemia by ultrasound stimulation, establishing a nanomaterials-enabled controlled cell therapy paradigm for diabetes.}, archive = {J_ANGEW}, author = {Yanling You and Junjie Jiang and Zhixin Chen and Ya-Xuan Zhu and Yihan Chen and Han Lin and Jianlin Shi}, doi = {10.1002/anie.202502780}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202502780}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sonoelectric nanonet-activated extracellular electron transfer for wireless non-genetic stimulation of pancreatic β cells}, volume = {64}, year = {2025}, }
• (2025). Individual virus detection by Peptide–Gold nanocluster-assembled artificial binder. ANGEW, 64(37), e202502421. (www)

  @article{ , abstract = {Ultrasensitive point-of-care detection is urgently required for viruses with high infectivity and lethality rates. In this study, we developed a direct detection platform, a peptide–gold nanocluster-assembled binder (PEGNAB), in which antigen-binding polymeric peptides are modified on a single gold nanocluster. This innovative platform has been applied to detect the influenza A virus (IAV), and it exhibits a high affinity for its spike protein, hemagglutinin, owing to its multisite binding mechanism. Approximately 500–800 PEGNAB particles were bound per virion, enabling individual virus detection through signal amplification. The linear detection range for IAV was 1–100 copies per well. A PEGNAB-based IAV antigen assay kit and paper strip were developed, offering simple operation, cost-effectiveness, and ultra-high sensitivity. In a double-blind trial involving 130 throat swabs (80 positive and 50 negative specimens), the PEGNAB kit achieved 98.8% sensitivity and 96% specificity, and the PEGNAB strip achieved 97.5% sensitivity and 96% specificity, as validated against quantitative polymerase chain reaction. The results demonstrate that different PEGNAB-based target binding modes can be readily adapted to various pathogens by altering the peptide sequence.}, archive = {J_ANGEW}, author = {Fei Qu and Yuqiu Zi and Ti Liu and Zhongyao Jiang and Yujie He and Chang Xu and Yue Tang and Bo Tang}, doi = {10.1002/anie.202502421}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202502421}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Individual virus detection by Peptide–Gold nanocluster-assembled artificial binder}, volume = {64}, year = {2025}, }
• (2025). Dizygotic atomic platinum and palladium on carbon for high-performance ethanol and methanol electro-oxidation. ANGEW, 64(37), e202502348. (www)

  @article{ , abstract = {Dizygotic-atom-site catalysts (DASCs), consisting of multi-atomic dispersed catalytic centers, perform well in several reactions but have poor electrocatalytic activity toward alcohol electro-oxidation. In this study, DASCs of atomically dispersed platinum and palladium on nitrogen-doped carbon nanocages (Pt 1 Pd 1 /NCNC) are successfully synthesized using an impregnation–adsorption method. The Pt 1 Pd 1 /NCNC catalyst has higher mass activity toward ethanol and methanol oxidation than commercial Pt/C and Pd/C. In contrast, Pt or Pd single-atom catalysts on nitrogen-doped carbon nanocages are virtually inert. Ethanol and methanol on Pt 1 Pd 1 /NCNC are electro-oxidized to acetate ion and CO 2 as the final product, respectively. Pt 1 Pd 1 /NCNC exhibits long-term stability toward ethanol and methanol oxidation due to the absence of the CO intermediate. Ab initio simulations show that Pt 1 Pd 1 /NCNC optimizes the ethanol oxidation pathway thanks to a lower energy barrier and onset potential than individual single Pt or Pd atom catalysts on NCNC. This study opens a new path to developing advanced DASCs for alcohol oxidation.}, archive = {J_ANGEW}, author = {Zhiqi Zhang and Jiapeng Liu and Shangqian Zhu and Yuhao Wang and Jian Wang and Minhong Xu and Jie Zhao and Zheng Wang and Dewang Zeng and Jianrong Zeng and Yufei Song and Chih-Wen Pao and Zhiwei Hu and Jongwoo Lim and Rui Xiao and Minhua Shao and Francesco Ciucci}, doi = {10.1002/anie.202502348}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202502348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dizygotic atomic platinum and palladium on carbon for high-performance ethanol and methanol electro-oxidation}, volume = {64}, year = {2025}, }
• (2025). Regiodivergent and enantioselective hydroboration of dienol ethers. ANGEW, 64(37), e202501767. (www)

  @article{ , abstract = {Transition metal-catalyzed asymmetric hydroboration of alkenes is one of the most straightforward methods for the synthesis of chiral organoboron compounds and has been well-established. While significant progress has been made in the catalytic enantioselective hydroboration of simple dienes, the development of regiodivergent and enantioselective hydroboration of more challenging substrates such as heteroatom-substituted or trisubstituted dienes remains limited. Here, we disclose a cobalt-catalyzed regiodivergent and enantioselective hydroboration of dienol ethers using a commercially available Co(acac) 2 catalyst and chiral ligands. The reaction exhibits good functional group compatibility and broad substrate scope, selectively affording 1,2-, 4,1-, 1,4-, and 4,3-hydroboration products in good yields and high regio- and enantioselectivities (up to >99%). Mechanistic studies, including deuterium-labeling, kinetic, and UV–vis experiments, suggest the involvement of Co–H species as active catalysts in the reactions. The powerful conversion capabilities of the products are demonstrated by various downstream transformations and the efficient preparation and late-stage elaboration of bioactive compounds.}, archive = {J_ANGEW}, author = {Honghui Ma and Wenke Dong and Wanxiang Zhao}, doi = {10.1002/anie.202501767}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202501767}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regiodivergent and enantioselective hydroboration of dienol ethers}, volume = {64}, year = {2025}, }
• (2025). Engineering peripheral metal-oxide catalysis: Interparticle spacing in Cu/ZrO2 catalysts for methanol synthesis by CO2 hydrogenation. ANGEW, 64(37), e202420126. (www)

  @article{ , abstract = {The periphery surrounding oxide-supported metal nanoparticles plays a crucial role in many catalytic reactions that exhibit strong metal-oxide promotional effects. Engineering this catalytically active periphery, where kinetically relevant surface intermediates are efficiently turned over, offers a pathway to optimized performance, yet it remains challenging due to the need for precise control over nanospatial catalyst features. Herein, we address this subject for the relevant case of methanol synthesis by CO 2 hydrogenation on Cu/ZrO 2 catalysts. The methanol synthesis rate reaches a maximum at a surface-to-surface Cu interparticle distance of ca. 15 nm. Operando modulation–excitation diffuse reflectance infrared spectroscopy reveals that this optimal spacing maximizes the fraction of surface-bound HCOO* intermediates, stabilized on coordinatively unsaturated Zr(IV) Lewis acid sites on the ZrO 2 support, which are dynamically involved in catalysis. This particle spacing represents a shift in the reaction's kinetic control regime and the apparent activation energy for methanol synthesis. Engineering Cu interparticle spacing to the optimal value results in exceptionally high metal-specific methanol formation rates under industrially relevant reaction conditions. More broadly, our findings highlight that, beyond metal particle size, interparticle spacing is a key design parameter for catalyst systems featuring functional metal-oxide interfaces.}, archive = {J_ANGEW}, author = {Iván López-Luque and Jannis Hack and Tania Ródenas and Wilson Henao and Bernat Mundet and Prathamesh Patil and Christian M. Pichler and Carlo Marini and Giovanni Agostini and Daniel M. Meier and Gonzalo Prieto}, doi = {10.1002/anie.202420126}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {37}, pages = {e202420126}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering peripheral metal-oxide catalysis: Interparticle spacing in Cu/ZrO2 catalysts for methanol synthesis by CO2 hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Alkali metal cations impact the selectivity of radical-mediated electrochemical C─H chlorination. ANGEW, 64(36), e202583602. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583602}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202583602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Alkali metal cations impact the selectivity of radical-mediated electrochemical C─H chlorination}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Chiral self-sorting of flexible covalent organic pillars for adaptive molecular recognition. ANGEW, 64(36), e202583601. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583601}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202583601}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Chiral self-sorting of flexible covalent organic pillars for adaptive molecular recognition}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Conditional stabilization of the hypoxia-inducible factor HIF1α: Photoswitchable stapled peptides prevent elongin BC–Mediated degradation (Angew. chem. int. ed. 36/2025). ANGEW, 64(36), e202517898. (www)

  @article{ , archive = {J_ANGEW}, author = {Van Tuan Trinh and Sabrina Fischer and Lei Zhang and Heiko Geisler and Belen Pardo and Robert Liefke and Frank Abendroth and Olalla Vázquez}, doi = {10.1002/anie.202517898}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202517898}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Conditional stabilization of the hypoxia-inducible factor HIF1α: Photoswitchable stapled peptides prevent elongin BC–Mediated degradation (Angew. chem. int. ed. 36/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Metal-responsive up-regulation of bifunctional disulfides for suppressing protein misfolding and promoting oxidative folding (Angew. chem. int. ed. 36/2025). ANGEW, 64(36), e202517793. (www)

  @article{ , archive = {J_ANGEW}, author = {Keita Mori and Tsubura Kuramochi and Motonori Matsusaki and Yuki Hashiguchi and Masaki Okumura and Tomohide Saio and Yoshiaki Furukawa and Kenta Arai and Takahiro Muraoka}, doi = {10.1002/anie.202517793}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202517793}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Metal-responsive up-regulation of bifunctional disulfides for suppressing protein misfolding and promoting oxidative folding (Angew. chem. int. ed. 36/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Is a malleable active site loop the key to high substrate promiscuity? hybrid, biocatalytic route to structurally diverse taxoid side chains with remarkable dual stereocontrol (Angew. chem. int. ed. 36/2025). ANGEW, 64(36), e202517791. (www)

  @article{ , archive = {J_ANGEW}, author = {Gaurav P. Kudalkar and Florian Leidner and Nivesh Kumar and Jared L. Hass and Peter Madzelan and Douglas R. Powell and Victor W. Day and Pierre Le Magueres and Joseph D. Ferrara and Lee M. Daniels and Akihito Yamano and Sho Ito and Wei Niu and Helmut Grubmüller and Mark A. Wilson and David B. Berkowitz}, doi = {10.1002/anie.202517791}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202517791}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Is a malleable active site loop the key to high substrate promiscuity? hybrid, biocatalytic route to structurally diverse taxoid side chains with remarkable dual stereocontrol (Angew. chem. int. ed. 36/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Exceptional second harmonic generation in ultraviolet nonlinear optical oxyfluoroniobate crystals via structural fingerprint optimization of polar chains (Angew. chem. int. ed. 36/2025). ANGEW, 64(36), e202517320. (www)

  @article{ , archive = {J_ANGEW}, author = {Congcong Jin and Yang Li and Jin Seong Kim and Jong-Hoon Lim and Hongbo Huang and Chong-An Chen and Jihyun Lee and Yejin Heo and Bingbing Zhang and Joon Ik Jang and Kang Min Ok}, doi = {10.1002/anie.202517320}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202517320}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Exceptional second harmonic generation in ultraviolet nonlinear optical oxyfluoroniobate crystals via structural fingerprint optimization of polar chains (Angew. chem. int. ed. 36/2025)}, volume = {64}, year = {2025}, }
• (2025). Qian zhao. ANGEW, 64(36), e202515792. (www)

  @article{ , archive = {J_ANGEW}, author = {Qian Zhao}, doi = {10.1002/anie.202515792}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202515792}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Qian zhao}, volume = {64}, year = {2025}, }
• (2025). Gang-wei wang. ANGEW, 64(36), e202515092. (www)

  @article{ , archive = {J_ANGEW}, author = {Gang-Wei Wang}, doi = {10.1002/anie.202515092}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202515092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gang-wei wang}, volume = {64}, year = {2025}, }
• (2025). The ConPET mechanism remains veiled: Reply to “Unlocking the ConPeT mechanism”. ANGEW, 64(36), e202514007. (www)

  @article{ , abstract = {In this journal, a Correspondence by Ventura, Cozzi, and Ceroni reported time-resolved absorption spectroscopy studies in the electron transfer process from cyanoarene photocatalyst 3,4,5,6-tetrakis(diphenyl amino)phthalonitrile (4DPAPN) in the presence of tetrabutylammonium oxalate (TBAOx). This was used as a model reaction to investigate the mechanism of consecutive photoinduced electron transfer (ConPET) in our previously reported asymmetric [3+2] photocycloaddition. They proposed a new electron transfer pathway in which the electron from the excited state of the radical anion 4DPAPN* •− solvated in acetonitrile. This article replies to their Correspondence, including: the experimental and theoretical analysis on the driving force of electron transfer and a series of new experiments conducted with purer reagents under more stringent conditions, which suggest that the process of proton-coupled electron transfer (PCET) followed by ConPET cannot be excluded, as proposed in our previous publication. Yet, Ceroni et al.’s efforts to study organic photochemical reactions using time-resolved spectroscopy remain worthwhile, and their proposed mechanism also led us to consider other possible pathways for the reaction. This article concludes with a series of constructive suggestions for further studying the ConPET mechanism using time-resolved absorption spectroscopy and other techniques.}, archive = {J_ANGEW}, author = {Yan Zhang and Zhenbo Guo and Ronghui Qiu and Zhenxian Ren and Jingjing Huo and Yin Yang and Baokun Qiao and Zhiyong Jiang and Tianfei Liu}, doi = {10.1002/anie.202514007}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202514007}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The ConPET mechanism remains veiled: Reply to “Unlocking the ConPeT mechanism”}, volume = {64}, year = {2025}, }
• (2025). Correction to “Development of an automated workflow for screening the assembly and Host–Guest behavior of metal-organic cages towards accelerated discovery”. ANGEW, 64(36), e202513796. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202513796}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202513796}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Development of an automated workflow for screening the assembly and Host–Guest behavior of metal-organic cages towards accelerated discovery”}, volume = {64}, year = {2025}, }
• (2025). A homobimetallic frustrated lewis pair cobalt catalyst for the methanolysis of hydrosilanes. ANGEW, 64(36), e202513522. (www)

  @article{ , abstract = {The bimetallic Co(I)/Co(–I) complex [Co(CO) 2 (κ 3 - P , N , P -PN H P)][Co(CO) 4 ] ( 1 ) has shown excellent activities in the methanolysis of hydrosilanes, surpassing the related bimetallic Co(I)/Co(–I) complex [Co(CO)(PMe 2 Ph)(κ 3 - P , N , P -PN H P)][Co(CO) 4 ] ( 2 ), the Co(II) complex [Co(Cl) 2 (κ 3 - P , N , P -PN H P)] ( 3 ), and the Co(I) complex [Co(CO) 2 (κ 3 - P , N , P -PN H P)]Cl ( 4 ). A comprehensive DFT study of the plausible reaction mechanisms indicates that the enhanced activity of 1 can be attributed to the presence of the [Co(CO) 4 ] – anion, which enables a frustrated Lewis pair (FLP) mechanism that provides a low energy pathway for the heterolytic splitting of the Si─H bond. The reaction mechanism entails the coordination of the hydrosilane to the Co(I) center upon decoordination of the amine functionality of the PN H P ligand, followed by heterolytic splitting of the Si─H bond with the participation of the Co(I) and Co(–I) centers. Then, the PhSiH 2 group at the Co(–I) center is transferred to the oxygen atom of a methanol molecule, which affords the [H 2 SiPh(HOMe)] + cation, regenerating the [Co(CO) 4 ] – species. [H 2 SiPh(HOMe)] + protonates the hydride at the Co(I) center, leading to the formation of H 2 and the corresponding silyl ether. Alternative reaction pathways, including alternative ionic mechanisms or NH-assisted bifunctional mechanisms, result in higher activation energies.}, archive = {J_ANGEW}, author = {Ana Luque-Gómez and Daniel Barrena-Espés and Pilar García-Orduña and Andrea Pérez-García and Miguel A. Casado and Julen Munarriz and Manuel Iglesias}, doi = {10.1002/anie.202513522}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202513522}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A homobimetallic frustrated lewis pair cobalt catalyst for the methanolysis of hydrosilanes}, volume = {64}, year = {2025}, }
• (2025). Dual-sided multidentate coordination strategy enables record birefringence in UV-transparent antimony-based hybrid crystals. ANGEW, 64(36), e202513511. (www)

  @article{ , abstract = {Achieving ultrahigh birefringence in UV-transparent materials remains fundamentally constrained by the trade-off between strong optical anisotropy and wide bandgap transparency. Herein, we report a dual-sided multidentate coordination (DMC) strategy to construct two butterfly-shaped UV organic–inorganic hybrid crystals—(C 6 H 4 NO 2 ) 2 SbF (PCSF) and (C 10 H 6 NO 2 ) 2 SbF (QCSF)—in which planar π-conjugated bidentate ligands symmetrically chelate stereochemically active lone pair (SCALP) Sb 3+ centers. This coordination architecture enforces coplanar alignment of optical functional units and promotes dense π–π stacking, thereby significantly enhancing macroscopic birefringence. Notably, QCSF achieves a record-high birefringence of Δ n = 0.87 at 546 nm, surpassing all previously reported lone-pair-containing halide crystals with UV transparency. The exceptional optical performance is attributed to the unique [SbN 2 O 2 F] coordination geometry, near-planar molecular configuration, and extended π-electron delocalization. First-principles calculations reveal that the observed anisotropy stems from synergistic orbital coupling between the Sb centers and the π-conjugated organic ligands. This work introduces a broadly applicable molecular design paradigm for next-generation birefringent crystals that simultaneously offer high optical anisotropy and UV transparency.}, archive = {J_ANGEW}, author = {Pu Zhang and Xuehua Dong and Ling Huang and Zhien Lin and Yuqiao Zhou and Guohong Zou}, doi = {10.1002/anie.202513511}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202513511}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-sided multidentate coordination strategy enables record birefringence in UV-transparent antimony-based hybrid crystals}, volume = {64}, year = {2025}, }
• (2025). Sub-Ångstrom pore engineering in carbon molecular sieves realizes diffusion-gated kinetic sieving of alkenes from alkanes. ANGEW, 64(36), e202513448. (www)

  @article{ , abstract = {Sub-Ångstrom pore engineering offers a new paradigm for molecular separations. Here, we report sucrose-derived carbon molecular sieves (CMSs) with precisely tailored sub-Ångstrom slit pores that enable diffusion-gated kinetic sieving for the challenging separation of alkenes from alkanes. The optimized materials, C-Suc-650 and C-Suc-750, set new industry-leading standards for the kinetic separation of C 3 H 6 /C 3 H 8 and C 2 H 4 /C 2 H 6 , respectively. Through a combination of breakthrough experiments, pressure swing adsorption (PSA) simulations, and molecular dynamics (MD) modeling, we demonstrate that these sieves consistently achieve >99.9% alkene purity, with outstanding selectivity, rapid uptake kinetics, and remarkably low energy consumption. Mechanistic studies reveal that slit pore architecture uniquely enhances alkene diffusion while hindering alkane movement, establishing a clear design principle for next-generation, energy-efficient gas separations. These results provide a blueprint for exploiting diffusion-gated kinetic sieving at the sub-Ångstrom scale to address longstanding challenges in industrial gas purification.}, archive = {J_ANGEW}, author = {Fuqiang Chen and Hua Shang and Guangtong Hai and Xinlei Huang and Zhe Chu and Haoran Sun and Liu Yang and Qiwei Yang and Zhiguo Zhang and Qilong Ren and Zongbi Bao}, doi = {10.1002/anie.202513448}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202513448}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sub-Ångstrom pore engineering in carbon molecular sieves realizes diffusion-gated kinetic sieving of alkenes from alkanes}, volume = {64}, year = {2025}, }
• (2025). Privileged chiral photocatalysts. ANGEW, 64(36), e202513320. (www)

  @article{ , abstract = {Privileged chiral catalysts have transformed asymmetric synthesis, conferring generality to processes that are routinely leveraged in the construction of societally important functional small molecules. Operating in the ground state, these catalysts are conspicuous in their ability to simultaneously regulate reactivity and translate chiral information, often with broad substrate tolerance: this technology continues to expedite chemical space exploration. In stark contrast to the specificity of many enzymatic transformations, this promiscuity affords remarkable latitude for creative endeavour in synthesis. Given the transformative impact that stereoselective photocatalysis has had over the last decade, identifying privileged chiral catalysts that permit reactivity and enantioselectivity to be regulated in excited-state scenarios has emerged as an attractive but challenging frontier. Providing solutions to address this paradox will require the reactivity/selectivity divide to be reconciled through the validation of chiral scaffolds that effectively operate in non-ground state environments. Inspired by the venerable treatment by Yoon and Jacobsen entitled “ Privileged chiral catalysts ” ( Science 2003 , 299 , 1691–1693), this mini-review is intended to survey the conception and evolution of privileged chiral photocatalyst scaffolds, and offer a perspective on emerging contenders.}, archive = {J_ANGEW}, author = {Emanuel Studer and Smita Mandal and Timo Stünkel and Ryan Gilmour}, doi = {10.1002/anie.202513320}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202513320}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Privileged chiral photocatalysts}, volume = {64}, year = {2025}, }
• (2025). Donor engineering for high performance n-type OECT materials with exceptional operational stability. ANGEW, 64(36), e202513182. (www)

  @article{ , abstract = {Donor–acceptor (D–A) conjugated polymeric mixed ionic–electronic conductors (PMIECs) have been widely used in organic electrochemical transistors (OECTs) due to their structural diversity and the tunability of their frontier molecular orbital (FMO) energy levels. However, the slower development of n-type materials compared to p-type ones limits their potential in advanced technological applications. In this study, we design and synthesize a novel thiophene-based donor building block, 2,3-di(thiophen-2-yl)fumaronitrile ( DTFMCN ), for D–A conjugated n-type PMIECs through donor engineering strategies. DTFMCN can be easily synthesized from commercially available starting materials via a simple one-step process. The DTFMCN-based D–A conjugated polymers, S-DTFMCN and B-DTFMCN , exhibit extremely low-lying lowest unoccupied molecular orbital (LUMO) energy levels and show typical n-type characteristics. OECT devices based on these polymers demonstrate ultra-low threshold voltages (6 and 40 mV) and high µ C* values of 13.49 and 13.57 F cm −1 V −1 s −1 , respectively. More importantly, these devices exhibit exceptionally high operational stability; the current retention rate after 168 minutes of operation is 96%, making them one of the most stable n-type OECT devices reported to date. This study highlights the effectiveness of DTFMCN in improving the operational stability of n-type OECT devices, offering promising potential for applications in bioelectronics.}, archive = {J_ANGEW}, author = {Riqing Ding and Xiage Zhang and Yidan Luan and Meishan Peng and Wantao Chen and Sijing Wang and Shengyao Su and Shunyang Lu and Sang Young Jeong and Han Young Woo and Xugang Guo and Kui Feng and Zi-Hao Guo}, doi = {10.1002/anie.202513182}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202513182}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Donor engineering for high performance n-type OECT materials with exceptional operational stability}, volume = {64}, year = {2025}, }
• (2025). Design of tough 3D printable elastomers with human-in-the-loop reinforcement learning. ANGEW, 64(36), e202513147. (www)

  @article{ , abstract = {The development of high-performance elastomers for additive manufacturing requires overcoming complex property trade-offs that challenge conventional material discovery pipelines. Here, a human-in-the-loop reinforcement learning (RL) approach is used to discover polyurethane elastomers that overcome pervasive stress–strain property tradeoffs. Starting with a diverse training set of 92 formulations, a coupled multi-component reward system was identified that guides RL agents toward materials with both high strength and extensibility. Through three rounds of iterative optimization combining RL predictions with human chemical intuition, we identified elastomers with more than double the average toughness compared to the initial training set. The final exploitation round, aided by solubility prescreening, predicted twelve materials exhibiting both high strength (>10 MPa) and high strain at break (>200%). Analysis of the high-performing materials revealed structure-property insights, including the benefits of high molar mass urethane oligomers, a high density of urethane functional groups, and incorporation of rigid low molecular weight diols and unsymmetric diisocyanates. These findings demonstrate that machine-guided, human-augmented design is a powerful strategy for accelerating polymer discovery in applications where data is scarce and expensive to acquire, with broad applicability to multi-objective materials optimization.}, archive = {J_ANGEW}, author = {Johann L. Rapp and Dylan M. Anstine and Filipp Gusev and Filipp Nikitin and Kelly H. Yun and Meredith A. Borden and Vittal Bhat and Olexandr Isayev and Frank A. Leibfarth}, doi = {10.1002/anie.202513147}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202513147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of tough 3D printable elastomers with human-in-the-loop reinforcement learning}, volume = {64}, year = {2025}, }
• (2025). C(sp2)─H bond activation with a heterometallic Nickel–Aluminium complex. ANGEW, 64(36), e202512684. (www)

  @article{ , abstract = {Herein we present a ligand-catalyzed bond-breaking and making process that occurs with a Ni–Al heterometallic complex. While combinations of Ni pre-catalysts and Al additives are known for site-selective C─H functionalization, detailed studies of such systems are rare. Combining [Ni(COD) 2 ] and [(BDI)AlH 2 ] ( 1 ; BDI = 2,6-diisopropylphenyl-β-methyldiketiminate) results in facile formation of a Ni–Al heterometallic complex [( η 4 -COD)Ni{( μ -H) 2 Al(BDI)}] ( 2 ; COD = 1,5-cyclooctadiene). Once generated, this species can effect the C(sp 2 )─H activation of 4-dimethylaminopyridine (DMAP) or pyridine with concomitant H 2 evolution, a process that is accelerated through addition of PCy 3 . The mechanism was studied through kinetics, kinetic isotope effects (KIEs), isotope labeling studies, and modeling. The reaction is 1 st order in PCy 3 and proceeds with a KIE of 0.9–1.1. Support is provided for a pathway involving the synergistic action of both metals, promoted by reversible coordination of the phosphine. The data suggest that both C─H oxidative addition and H 2 reductive elimination steps in this system are readily accessible and are not rate limiting. This finding has implications for future catalyst design using combinations of Ni and Al metals and suggests that control of ligand exchange steps may be the most important consideration in determining the rate of reaction.}, archive = {J_ANGEW}, author = {Joseph A. Zurakowski and Benedek Stadler and Marcus W. Drover and Mark R. Crimmin}, doi = {10.1002/anie.202512684}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C(sp2)─H bond activation with a heterometallic Nickel–Aluminium complex}, volume = {64}, year = {2025}, }
• (2025). Exceptional second harmonic generation in ultraviolet nonlinear optical oxyfluoroniobate crystals via structural fingerprint optimization of polar chains. ANGEW, 64(36), e202512618. (www)

  @article{ , abstract = {Partial fluorination of oxides has positioned oxyfluorides as a promising class of nonlinear optical (NLO) materials owing to their balanced optical properties. However, effectively arranging optical chromophores to achieve strong optical nonlinearity remains challenging. In this study, we explore the structural chemistry of 1 [NbOF 4 ] ∞ chain-based oxyfluoroniobates and establish a molecular geometric framework to quantify key structural fingerprint factors , namely, the ∠(O─Nb─O′) bond angle, χ [F,Nb,Nb′,F′] torsion angle, chain alignment, and distortion of [NbO 2 F 4 ] nodes. Theoretical calculations confirm that these factors critically influence second harmonic generation (SHG) activity. By integrating π-conjugated biuret (C 2 H 5 N 3 O 2 ) molecules with optimally aligned 1 [NbOF 4 ] ∞ chains, we synthesized (H 3 O)(Biu) 2 (NbOF 4 ) (Biu = biuret), a crystal exhibiting a record-breaking SHG response, reaching 10.8 times that of KH 2 PO 4 , among transition metal (TM) oxyfluorides. Its moderate birefringence (Δ n = 0.062 @1064 nm) and wide band gap ( E g = 4.50 eV) further support its potential as a high-performance ultraviolet (UV) NLO material. These results highlight the power of structural fingerprint optimization in fully activating polar chains and offer a new strategy for designing next-generation UV NLO crystals with enhanced SHG performance.}, archive = {J_ANGEW}, author = {Congcong Jin and Yang Li and Jin Seong Kim and Jong-Hoon Lim and Hongbo Huang and Chong-An Chen and Jihyun Lee and Yejin Heo and Bingbing Zhang and Joon Ik Jang and Kang Min Ok}, doi = {10.1002/anie.202512618}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exceptional second harmonic generation in ultraviolet nonlinear optical oxyfluoroniobate crystals via structural fingerprint optimization of polar chains}, volume = {64}, year = {2025}, }
• (2025). Access to chiral cyclic β-enaminones via enantioselective imine condensation. ANGEW, 64(36), e202512405. (www)

  @article{ , abstract = {We report herein an unprecedented catalytic enantioselective synthesis of cyclic β-enaminones from simple meso-1,3-diketones via chiral phosphoric acid-catalyzed desymmetrization through imine condensation. This transformation provides efficient access to a broad array of cyclic β-enaminones and acridinones bearing a remote β-stereogenic center, delivering products in excellent yields and enantioselectivities under mild conditions with a straightforward protocol. Furthermore, the resulting β-enaminones can undergo one-step derivatizations to furnish diverse enantioenriched carbo- and heterocycles, highlighting their high potential for applications in medicinal chemistry.}, archive = {J_ANGEW}, author = {Yaru Gao and Zhi-Keng Lin and Mingjin Liu and Jiameng Deng and Tao Zhang and Bin-Miao Yang and Yu Zhao}, doi = {10.1002/anie.202512405}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512405}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Access to chiral cyclic β-enaminones via enantioselective imine condensation}, volume = {64}, year = {2025}, }
• (2025). Iron-catalyzed carbonylation reactions with carbon monoxide. ANGEW, 64(36), e202512346. (www)

  @article{ , abstract = {The utilization of carbon monoxide (CO) as an inexpensive and indispensable C 1 feedstock for the efficient construction of diverse carbonylated compounds has been a subject of numerous studies for decades. Nowadays, transition metal-catalyzed carbonylation represents a pivotal synthetic approach for the generation of carbonyl-containing molecules. Among the known catalysts for these transformations, non -noble metal-based systems have garnered increasing interest in recent years due to their substantial advantages, including wide availability, low cost, and low toxicity. In this review, we have summarized and discussed original and recent developments in iron-catalyzed carbonylative transformations, wherein CO is utilized as the C 1 feedstock.}, archive = {J_ANGEW}, author = {Kangkang Sun and Guo-Ping Lu and Wei Han and Matthias Beller}, doi = {10.1002/anie.202512346}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512346}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron-catalyzed carbonylation reactions with carbon monoxide}, volume = {64}, year = {2025}, }
• (2025). Chiral co-assembled liquid crystal polymer network enabled by in-situ photopolymerization for high-performance CP-OLEDs. ANGEW, 64(36), e202512257. (www)

  @article{ , abstract = {Circularly polarized organic light-emitting diodes (CP-OLEDs) show great promise for next-generation display technologies. However, achieving high dissymmetry factors (| g EL |) in circularly polarized electroluminescence (CP-EL) remains a significant challenge. In this study, we construct a novel chiral co-assembled cholesteric liquid crystal polymer network ( ChLC-PN ) as an emitting layer (EML) to enhance CP-EL via a facile in situ photopolymerization strategy. The ChLC-PN was fabricated by UV-induced polymerization (365 nm, 200 mW cm − 2 , 2 min, N₂ atmosphere) of a chiral co-assembly system comprising liquid crystal monomer ( LCM ) and chiral inducers ( R / S -Cz ). Notably, the resulting ( R / S -Cz) 0.01 -(LCP) 0.99 based devices demonstrate sky-blue CP-EL with a maximum | g EL | value of 0.012. This work presents the first report of high-performance CP-OLEDs utilizing a chiral co-assembled cholesteric liquid crystal rigid polymer network, offering a promising platform for simple, stable, and scalable fabrication of future CP-OLED devices.}, archive = {J_ANGEW}, author = {Chunya Fu and Dong Li and Chao Liu and Yu Zhang and Junsheng Zhang and Yixiang Cheng}, doi = {10.1002/anie.202512257}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512257}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral co-assembled liquid crystal polymer network enabled by in-situ photopolymerization for high-performance CP-OLEDs}, volume = {64}, year = {2025}, }
• (2025). Macromolecule-driven supramolecular polymerization induced by crowding effects. ANGEW, 64(36), e202512216. (www)

  @article{ , abstract = {Macromolecular crowding plays a crucial role in biological systems by regulating dynamic processes, yet its effects in fully synthetic environments remain largely unexplored. Here, we systematically investigate how excluded volume effects influence supramolecular polymerizations in organic media. We employ various discotic supramolecular monomers that assemble sequentially into polymers and kinetically-controlled higher-order aggregates (HOAs) only in the presence of macromolecular crowders. The phase diagram of the supramolecular assemblies reveals a strong dependence on the macromolecule concentration, size, and polarity, which can be tuned to control polymerization. Remarkably, at high crowder concentrations, large condensed and aligned assemblies were observed in dried samples, suggesting a transition to phase-separated states. By testing different monomers, macromolecules, and solvents, we establish the general applicability and versatility of macromolecular crowding in guiding supramolecular polymerization. This work provides fundamental insights into assembly processes in crowded environments and opens new avenues for applying macromolecular crowding beyond aqueous systems.}, archive = {J_ANGEW}, author = {Joost J. B. v. d. Tol and Magda M. J. Dekker and Ádám Müller and Puck Springintveld and E. W. Meijer and Ghislaine Vantomme}, doi = {10.1002/anie.202512216}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512216}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Macromolecule-driven supramolecular polymerization induced by crowding effects}, volume = {64}, year = {2025}, }
• (2025). Deuterated multi-resonance thermally activated delayed fluorescence emitters for pure-green organic light-emitting diodes with CIE coordinates of (0.16, 0.75) and long lifetimes. ANGEW, 64(36), e202512162. (www)

  @article{ , abstract = {Multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters, especially high-order B/N MR-TADF emitters, offer new opportunities in obtaining wide-color-gamut, high color purity, and highly efficient organic light-emitting diodes (OLEDs). Extending the device durability is still very challengeable for these emitters. Deuteration of emitters to slow down their degradation and lengthen device lifespan is a promising strategy. However, how to access deuterated high-order MR-TADF emitters remains to be explored. Herein, a synthetic protocol of high-order B/N products is proposed using deuterated starting materials and sequential borylation. Combining with fine-tuning electronic effect through adjusting position of tert -butyl ( t Bu) substituents, we successfully obtained deuterated triboron MR-TADF material ω’-DABNA-D that delivers precisely tuned pure-green emission with close-to-unity quantum yield and rapid reverse intersystem crossing (RISC). The resulting binary OLED approaches the BT.2020 standard with CIE coordinates of (0.16, 0.75) and demonstrates impressive external quantum efficiency (EQE) of 34.6% at maximum and 30.7% at 1000 cd m −2 . Additionally, an Ir(ppy) 3 -sensitized device shows excellent operational stability, with an extrapolated lifetime (LT 80 ) of 6078 h at an initial luminance of 1000 cd m −2 . This study hence offers a promising methodology toward high-performance OLED with long device lifetime.}, archive = {J_ANGEW}, author = {Mao Quan and Ze-Lin Zhu and Guohao Chen and Jingsheng Miao and Chuluo Yang}, doi = {10.1002/anie.202512162}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deuterated multi-resonance thermally activated delayed fluorescence emitters for pure-green organic light-emitting diodes with CIE coordinates of (0.16, 0.75) and long lifetimes}, volume = {64}, year = {2025}, }
• (2025). Cooperative activation of CO and pyridine by an Aluminum(I) complex ligated with a Silylene–Borane ligand. ANGEW, 64(36), e202512084. (www)

  @article{ , abstract = {Cooperative main-group systems based on alumylenes are highly attractive due to their potential for activating and transforming inert chemical bonds and small molecules. However, their development has been hindered by the scarcity of suitable supporting ligands. Herein, we report the synthesis of an amphiphilic carboranyl silylene–borane ligand ( 1 ) and demonstrate its effectiveness in stabilizing an aluminum(I) complex 2 . Complex 2 has been unambiguously characterized by spectroscopic analysis, X-ray diffraction analysis, and DFT calculations, which reveals a unique structure featuring both silicon(II)→aluminum(I) and aluminum(I)→boron(III) donor–acceptor bonds. The synergistic interplay between the silylene–borane ligand and the aluminum(I) center in 2 drives its unusual reactivity toward CO and pyridine activation, facilitating cleavage of the C≡O bond and dearomatization of pyridine.}, archive = {J_ANGEW}, author = {Jinghuang Lv and Xiao Fang and Fanshu Cao and Zhenbo Mo}, doi = {10.1002/anie.202512084}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202512084}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative activation of CO and pyridine by an Aluminum(I) complex ligated with a Silylene–Borane ligand}, volume = {64}, year = {2025}, }
• (2025). Dual-function tetrabenzylphosphonium groups as mitochondria-targeting artificial anion channels. ANGEW, 64(36), e202511936. (www)

  @article{ , abstract = {Artificial ion channels with specific organelle-targeting capabilities have been scarcely investigated. Here, we report the first-in-class mitochondria-targeting anion channels derived from a structurally simple tetrabenzylphosphonium framework, in stark contrast to its phenyl-based counterpart, which lacks anion transport activity. Structural and computational analyses underscore the critical role of the methylene (CH 2 ) linkers in the benzyl groups. These CH 2 units reduce positive charge delocalization to enhance σ-hole–anion interactions, while also enabling H-atoms from both the CH 2 linkers and aromatic rings to cooperatively form multiple C─H⋯anion H─bonds. In further conjunction with the rigid benzene rings, they help create sufficient spatial voids to accommodate anion translocation, collectively facilitating and energizing the anion transport process. Among the series studied, those bearing methyl and tert -butyl substituents exhibit the highest transport activity via a channel mechanism, with a conductance value as high as 26.5 ± 0.8 pS. Furthermore, leveraging the cationic nature of the quaternary phosphonium center, this family of anion channels readily achieves targeted mitochondrial localization, demonstrating potent anticancer activity, with IC 50 values ranging from 1.42 to 3.04 µM across three cancer cell lines.}, archive = {J_ANGEW}, author = {Fei Gou and Xinlei Huangfu and Qiuting Wang and Zihong Yang and Xiyu Yuan and Wenju Chang and Jie Shen and Wen-Xiong Zhang and Huaqiang Zeng}, doi = {10.1002/anie.202511936}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511936}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-function tetrabenzylphosphonium groups as mitochondria-targeting artificial anion channels}, volume = {64}, year = {2025}, }
• (2025). Surface protected organozirconium catalyzes C─H alumination of saturated hydrocarbons. ANGEW, 64(36), e202511893. (www)

  @article{ , abstract = {Surface grafted organozirconium catalyzes C─H/Et─Al exchange reactions, involving saturated hydrocarbons and AlEt 3 , to afford organoaluminum compounds and ethane. The Zr(O t Bu) 3 @SiO 2 -Al 2 O 3–700 ( 1 ) catalyst contains monopodal ≡SiO─Zr(O t Bu) 3 and only a few residual silanols (<5%). Nonetheless, these silanols are the Achille's heel of 1 , providing a pathway for surface and catalyst degradation during catalysis, limiting the alkylaluminum yield and catalyst turnover. Support degradation, involving the cleavage of Si─O bonds by activated surface organometallics, is inhibited by capping silanols with ─SiMe 3 . Residual silanols in 1 react with allyltrimethylsilane, as determined by solid-state 13 C and 29 Si nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy, and reaction stoichiometry, to form Zr(O t Bu) 3 /SiMe 3 @SiO 2 -Al 2 O 3–700 ( 2 ), which is resistant to degradation by AlEt 3 . C─H alumination of dodecane catalyzed by 2 produces higher yields of the 1-dodecylaluminum product in comparison to 1 , and in >95% selectivity. Additionally, methane undergoes 2 -catalyzed C─H alumination, providing a route to AlMe 3 .}, archive = {J_ANGEW}, author = {Sayak Banerjee and Jessica Rodriguez and Marco Mais and Frédéric A. Perras and Aaron D. Sadow}, doi = {10.1002/anie.202511893}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface protected organozirconium catalyzes C─H alumination of saturated hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). Isotope engineering of tetraphenylethylene: Aggregate-dependent enhancement of luminescence efficiency. ANGEW, 64(36), e202511678. (www)

  @article{ , abstract = {Aggregation-induced emission (AIE) luminogens, exemplified by tetraphenylethylene (TPE), exhibit enhanced fluorescence in aggregated states and have promising applications in display, photodetectors, fluorescent probes, bioimaging, and biomedicine. This study investigates the influence of varying degrees of deuteration on the photophysical properties of TPE across different aggregation states. Through the synthesis of partially and fully deuterated TPE derivatives (TPE-5d, TPE-10d, and TPE-20d), combined with steady-state fluorescence spectroscopy, time-resolved fluorescence measurements, transient absorption spectroscopy, and density functional theory (DFT) calculations, we elucidate the dual role of deuteration in modulating nonradiative decay pathways. In loosely packed nanoaggregates, increased deuteration enhances photoluminescence quantum yields (PLQY) and extends fluorescence lifetimes by reducing internal conversion rates. Conversely, in tightly packed crystalline states, deuteration leads to decreased PLQY and shortened lifetimes, attributable to the Duschinsky rotation effect (DRE), which enhances inter-mode coupling and internal conversion. Additionally, deuteration significantly prolongs the operational lifetime of blue organic light-emitting diode (OLED) devices, doubling the device lifespan in TPE-20d compared to TPE. This work underscores the necessity of evaluating structure–property relationships at the aggregate level, rather than solely at the molecular level, to fully comprehend and optimize AIE phenomena. These findings highlight the potential of isotope engineering in designing durable and efficient AIE luminogens for applications in optoelectronics and bioimaging.}, archive = {J_ANGEW}, author = {Siwei Zhang and Fulong Ma and Jinhui Jiang and Bo Wu and Junyi Gong and Guang Xu and Chao Li and Tengteng Chen and Ryan T. K. Kwok and Jacky W. Y. Lam and Zheng Zhao and Ben Zhong Tang}, doi = {10.1002/anie.202511678}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511678}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isotope engineering of tetraphenylethylene: Aggregate-dependent enhancement of luminescence efficiency}, volume = {64}, year = {2025}, }
• (2025). Spontaneous nano-ZrO2 exsolution from ni-zr-O mixed oxides enables facile fabrication of ZrO2/Ni inverse catalysts for efficient COx methanation. ANGEW, 64(36), e202511453. (www)

  @article{ , abstract = {Ni-based inverse catalysts with nano-oxide dispersed on metallic substrates have emerged as promising candidates for low-temperature CO 2 methanation, but it remains challenging in facile synthesis of well-dispersed oxide-metal interactions. Herein, a spontaneous oxide exsolution strategy for the fabrication of Ni-based inverse catalyst via monodispersed Zr species of Ni-Zr-O mixed oxide is demonstrated, where precisely tailored calcination and reduction of the mixed oxide enable in situ nano-ZrO 2 segregation on the metallic Ni matrix. The formation evolution of inverse configuration is elucidated through comprehensive ex situ/in situ characterizations. X-ray photoelectron spectroscopy reveals the electron transfer between the exsolved ZrO 2 and the Ni matrix, indicating the presence of metal-oxide interactions. The prepared ZrO 2 /Ni inverse catalyst achieves ∼90% CO 2 conversion and >99% CH 4 selectivity at low-temperature of 200 °C, and also demonstrates excellent catalytic performance and dynamic operational stability in complex CO x hydrogenation reactions, validating its industrial applicability under realistic syngas-equivalent feedstock conditions.}, archive = {J_ANGEW}, author = {Xin Tang and Yuanchang Wang and Jinrong Zhang and Cheng Yu and Mengyao Cheng and Shiqing Yang and Xuguang Yang and Liangwei Liu and Lili Han and Yao Xu and Chuqiao Song and Lili Lin}, doi = {10.1002/anie.202511453}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511453}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spontaneous nano-ZrO2 exsolution from ni-zr-O mixed oxides enables facile fabrication of ZrO2/Ni inverse catalysts for efficient COx methanation}, volume = {64}, year = {2025}, }
• (2025). Amplifying circularly polarized luminescence with high dissymmetry factor over 10−2 based on robust point chirality triptycene derivatives. ANGEW, 64(36), e202511414. (www)

  @article{ , abstract = {Chiral organic luminescent materials are promising candidates as direct emitting layers (EMLs) in circularly polarized organic light-emitting diodes (CP-OLEDs). However, most conventional systems suffered poor thermal stability of chiral configurations and low luminescent dissymmetry factors. Herein, we reported a pair of triptycene-bridged enantiomers with a point chirality and a donor–acceptor architecture. Robust point chirality, originating from quaternary bridgehead-carbons, prevented the common racemization during thermal sublimation. Thanks to the reduced electric transition dipole moment (µ e ) in donor–acceptor architecture, tuned parallel alignment between the further reduced µ e and magnetic transition dipole moment (µ m ) in the exciplex emitter, and the utilized chiral exciplex host for energy transfer to phosphor, the corresponding dissymmetry factors of emitters were sequentially amplified from 3.3 × 10 −4 to 4.5 × 10 −3 , and to 8.1 × 10 −3 . Remarkably, the CP-OLED device simultaneously achieved outstanding electroluminescence performance with a high external quantum efficiency of 31.8% and a large dissymmetry factor of 2.2 × 10 −2 . This work provided a viable pathway for developing high-performance CP-OLED materials through synergistic structural, material, and device engineering.}, archive = {J_ANGEW}, author = {Yufeng Xie and Songkun Zeng and Wenbin Huang and Chenlong Wei and Zikai He}, doi = {10.1002/anie.202511414}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511414}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amplifying circularly polarized luminescence with high dissymmetry factor over 10−2 based on robust point chirality triptycene derivatives}, volume = {64}, year = {2025}, }
• (2025). Metalloenzyme-catalyzed asymmetric transfer hydrogenation for the synthesis of chiral amines. ANGEW, 64(36), e202511298. (www)

  @article{ , abstract = {Chiral amines are prevalent in natural products, pharmaceuticals, and organic catalysts. Their increasing demand has driven the advancement of synthetic methods. In this study, we developed a metalloenzyme-catalyzed asymmetric transfer hydrogenation method for the synthesis of chiral amines. Given the challenges of traditional chemical synthesis, which relies on precious metals and complex synthetic ligands, our approach utilizes base metals derived from natural metalloenzymes for transfer hydrogenation and employs protein scaffolds to achieve stereochemical control. Furthermore, in contrast to natural NAD(P)H-dependent C═N bond reductases, this strategy utilizes silanes as reducing agents and is entirely orthogonal to conventional NAD(P)H-dependent cellular functions. This reactivity highlights the potential to develop new-to-nature enzymatic functions capable of addressing challenges in both organic synthesis and biosynthesis.}, archive = {J_ANGEW}, author = {Dong Cui and Xiaochen Cai and Xinyu Duan and Yuchen Chu and Bingyi Li and Zhiguo Wang and Feng Cheng and Jian Xu}, doi = {10.1002/anie.202511298}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511298}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metalloenzyme-catalyzed asymmetric transfer hydrogenation for the synthesis of chiral amines}, volume = {64}, year = {2025}, }
• (2025). Ag⁺-mediated structural reconstruction of a metastable cu35 cluster toward Cu–Ag heterometallic architectures for superior electrocatalytic CO2-to-ethanol conversion. ANGEW, 64(36), e202511232. (www)

  @article{ , abstract = {Controlled structural transformations of metal nanoclusters (NCs) via dynamic bond reorganization provide fundamental insights into cluster reactivity and open avenues for functionality tuning. Here, we report a thiacalix[4]arene-protected Cu(I)-alkynide cluster, {NaCu 35 (TC4A) 4 (Ph-C≡C) 20 } ( Cu 35 ), which exhibits remarkable structural plasticity. This metastable cluster can grow into a Cu 36 species via ion substitution or undergo thermal-induced fragmentation to form a smaller Cu 14 cluster. Under thermal etching by Ag + ion, structural reconstruction is triggered, leading to the formation of the bimetallic Cu 14 Ag 6 and Cu 40 Ag 16 clusters. The structural reorganization significantly alters the catalytic outcomes in electrocatalytic CO 2 reduction. Although the monometallic Cu 35 and Cu 14 favor gaseous CH 4 /C 2 H 4 production, the bimetallic Cu 14 Ag 6 demonstrates remarkable selectivity for ethanol synthesis. Notably, Cu 14 Ag 6 achieves an impressive Faradaic efficiency (FE) of 49.27% for ethanol production, alongside a high partial current density of −67.94 mA cm −2 . This marks the highest ethanol selectivity reported to date for atomically precise cluster catalysts. Mechanistic investigations reveal that, compared to homometallic Cu⋯Cu dual sites (which typically favor C 2 H 4 ), the unique Ag⋯Cu⋯Cu trimetallic microstructure in Cu 14 Ag 6 is more thermodynamically favorable for asymmetric C─C coupling between *CHO and *OCH 2 , facilitating the formation of the key *CHO−*OCH 2 intermediate, which drives the ethanol-selective pathway.}, archive = {J_ANGEW}, author = {Xin-Yu Chen and Lan-Yan Li and Lan-Cheng Zhao and Qing-Yi Liu and Dang-Dang Ding and Li-Li Zhang and Xiao-Yan Sun and Li-Kai Wang and Hong-Bing Mo and Jun Yan and Chao Liu}, doi = {10.1002/anie.202511232}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511232}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ag⁺-mediated structural reconstruction of a metastable cu35 cluster toward Cu–Ag heterometallic architectures for superior electrocatalytic CO2-to-ethanol conversion}, volume = {64}, year = {2025}, }
• (2025). High-efficiency hydrogen oxidation for hydroxide exchange membrane fuel cells catalyzed by fivefold-twinned nickel nanoparticles. ANGEW, 64(36), e202511219. (www)

  @article{ , abstract = {The independent regulation of multiple intermediates is critically important for optimizing the electronic structure of nickel (Ni), thereby improving its catalytic performance in the hydrogen oxidation reaction (HOR). However, conventional regulation strategies based on the Hammer–Nørskov d-band model often change the hydrogen binding energy (HBE) and hydroxyl binding energy (OHBE) in a synchronized manner. Herein, we find that a catalyst consisting of fivefold-twinned ultrasmall Ni nanoparticles could tune HBE and OHBE individually via the strain effect. Experimental and theoretical calculations suggest that tensile strain in proximity to the twin boundary (TB) significantly enhances OHBE, allows for adjustable HBE due to unique geometric effects, and greatly reduces HBE at specific sites, enabling an unprecedented HOR activity. The catalyst has a high j k,m value of 106.6 mA mg Ni −1 , which is 24.2 times greater than that of Ni/C. The hydroxide exchange membrane fuel cell (HEMFC) with fivefold-twinned Ni nanoparticles anode delivers a peak power density (PPD) of 805 mW cm −2 with H 2 /O 2 gas feed, which is the highest among Ni-based electrocatalysts reported thus far. Furthermore, the catalyst also exhibits excellent long-term cycling performance, taking a giant step forward toward the commercialization of platinum group metal (PGM)-free HEMFCs.}, archive = {J_ANGEW}, author = {Pin Meng and Yang Yang and Jiahe Yang and Peichen Wang and Chenyang Bi and Hongda Shi and Yunlong Zhang and Xingyan Chen and Dingge Fan and Siyan Chen and Xi Lin and Dongdong Wang and Qianwang Chen}, doi = {10.1002/anie.202511219}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511219}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-efficiency hydrogen oxidation for hydroxide exchange membrane fuel cells catalyzed by fivefold-twinned nickel nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Molecular engineering of plant polyphenols into amorphous room-temperature phosphorescent materials. ANGEW, 64(36), e202511218. (www)

  @article{ , abstract = {Room-temperature phosphorescent (RTP) materials have potential applications in optoelectronics and bioimaging but encounter significant challenges. Traditional heavy-metal-based and crystalline systems are often toxic and environmentally sensitive, while strategies involving host–guest doping and encapsulation frequently suffer from phase separation and limited controllability—ultimately resulting in poor repeatability and restricted applications. Here, we developed a novel polyphenol-mediated molecular splicing and ring-locking strategy to incorporate benzo[c][1,2,5]thiadiazole (BZT) into polyphenol molecules, yielding a range of eco-friendly and processable amorphous single-component systems with a lifetime of up to 124 ms. Experimental and calculational analyses confirm that phosphorescence arises from synergistic interactions between polyphenol and BZT. Furthermore, phosphorescent nanoparticles (NPs) were synthesized via nanoprecipitation in tetrahydrofuran with 30% water content. These well-dispersed, metal-free NPs demonstrate excellent biocompatibility and low cytotoxicity, facilitating time-resolved luminescence imaging with minimal background fluorescence interference both in vitro and in vivo. This research establishes a versatile and sustainable design strategy for developing high-performance amorphous RTP materials using plant polyphenols, offering promising prospects for advanced biomedical applications.}, archive = {J_ANGEW}, author = {Guobin Yang and Yajing Zhang and Chuang Lei and Yunxiang He and Yizhen Wang and Huijing Li and Yanchao Wu and Junling Guo}, doi = {10.1002/anie.202511218}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511218}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular engineering of plant polyphenols into amorphous room-temperature phosphorescent materials}, volume = {64}, year = {2025}, }
• (2025). Conditional stabilization of the hypoxia-inducible factor HIF1α— photoswitchable stapled peptides prevent elongin BC–Mediated degradation. ANGEW, 64(36), e202511183. (www)

  @article{ , abstract = {Oxygen levels and its distribution are tightly regulated due to their critical impact on health. Hypoxia-inducible factors (HIFs) are traditionally recognized as key regulators of the transcriptional response to low oxygen (hypoxia). Recent research expanded their functions, highlighting their potential as therapeutic targets. Despite these advances, there is still a need for chemical biology tools that offer precise spatiotemporal control within the HIF network and output. Here, we introduce an optochemical approach that enables significant differences in expression of HIF1α-target genes depending on the photostationary state (PSS). Our photoswitchable stapled peptide PS B -BCB-04 stabilized HIF1α under normoxic conditions by targeting EloBC ( k i =  7.9 ± 1.3 nM) and preventing VHL-mediated degradation. Visible light allowed reversible regulation of peptide conformation, which entailed a sevenfold difference in its EloBC-binding capacity. In a proof-of-concept study, we demonstrated that inhibition of HIF1α degradation enabled isomer-specific expression of the vascular endothelial growth factor (VEGFA) in prostate cancer cells. Our results validated the potential of photopharmacological stabilization of HIF1α and provided a new toolbox for on-demand photocontrol over the HIF-signaling pathway as well as VHL-mediated degradation.}, archive = {J_ANGEW}, author = {Van Tuan Trinh and Sabrina Fischer and Lei Zhang and Heiko Geisler and Belen Pardo and Robert Liefke and Frank Abendroth and Olalla Vázquez}, doi = {10.1002/anie.202511183}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conditional stabilization of the hypoxia-inducible factor HIF1α— photoswitchable stapled peptides prevent elongin BC–Mediated degradation}, volume = {64}, year = {2025}, }
• (2025). Low-coordination indium single-atom sites anchored on a metal-organic framework single-layer boosts electroreduction of CO2 into formic acid. ANGEW, 64(36), e202511132. (www)

  @article{ , abstract = {The electroreduction of CO 2 under acidic conditions presents both scientific significance and technical challenges. Herein, we developed a post-synthetic modification strategy to anchor unexpected tetrahedral In(III) ions onto Zr-oxo clusters of a single-layer zirconium metal-organic framework (denoted as Zr-MOF-In ). Operating under harsh acidic conditions (pH = 1.67) at −1.8 V versus RHE, the Zr-MOF-In catalyst demonstrates exceptional performance with 95.7% Faradaic efficiency for formic acid production and a current density of 213.3 mA cm −2 . The system maintains operational stability over 20 h without notable activity decay. Remarkably, when integrated into a membrane electrode assembly electrolyzer with solid-state electrolyte at 4 V full-cell voltage, Zr-MOF-In continuously generates pure formic acid solution (505.5 mmol L −1 , 100% purity) free of electrolyte contamination, achieving a concentration 1.5-fold higher than the current state-of-the-art. Mechanistic investigations identify dual enhancement mechanisms: i) the low-coordinated In(III) single-atom sites facilitate dual *HCOO intermediate binding, enhancing reaction kinetics beyond conventional single-intermediate adsorption on high-coordination metal centers; and ii) the single-layer MOF configuration optimizes active site exposure, synergistically maximizing catalytic efficiency.}, archive = {J_ANGEW}, author = {Jun-Yi Li and Jia-Run Huang and Zhen-Hua Zhao and Hao-Lin Zhu and Pei-Qin Liao and Xiao-Ming Chen}, doi = {10.1002/anie.202511132}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511132}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-coordination indium single-atom sites anchored on a metal-organic framework single-layer boosts electroreduction of CO2 into formic acid}, volume = {64}, year = {2025}, }
• (2025). Spinel-layered heterostructure enables reversible oxygen redox in lithium manganese oxide. ANGEW, 64(36), e202511054. (www)

  @article{ , abstract = {Lithium-rich manganese-based layered oxides (LRMOs) have emerged as promising cathode materials for next-generation lithium-ion batteries (LIBs), primarily due to their exceptional capacity originating from oxygen redox chemistry. Although Li 2 MnO 3 (LMO) has been conventionally identified as the oxygen redox-active component in LRMOs, this layered material shows neither bulk redox activity nor reversible anion redox behavior in the absence of other transition metals (e.g., Ni and Co). Herein, we report a structural-engineered lithium manganese oxide with spinel-layered heterostructures (designated as LMO-SH), which exhibits reversible oxygen redox activities between lattice oxygen (O 2− ) and molecular oxygen (O 2 ) – the first documented instance of such redox behavior in a manganese-based material. Through combining experimental characterization and theoretical modeling, we establish that the interfacial architecture between the spinel and layered phases facilitates the Li + diffusion kinetics while simultaneously activating bulk oxygen redox processes. This mechanistic understanding not only advances fundamental knowledge of redox chemistry in LMO-based materials but also establishes new design principles for developing high-capacity cathodes through strategic phase engineering.}, archive = {J_ANGEW}, author = {Yanfang Wang and Cheng Li and Yulin Cao and Juping Xu and Dominic Gardner and Wilgner Lima da Silva and Yongcong Huang and Fangchang Zhang and Mingzhou Li and Yingzhi Li and Wen Yin and Kaili Zhang and Phoebe K. Allan and Zhouguang Lu}, doi = {10.1002/anie.202511054}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202511054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spinel-layered heterostructure enables reversible oxygen redox in lithium manganese oxide}, volume = {64}, year = {2025}, }
• (2025). Progressive learning-guided discovery of single-atom metal oxide catalysts for acidic oxygen evolution reaction. ANGEW, 64(36), e202510965. (www)

  @article{ , abstract = {The oxygen evolution reaction (OER) is a key bottleneck in clean energy conversion due to sluggish kinetics and high overpotentials. Transition metal single-atom catalysts offer great promise for OER optimization thanks to their high atomic efficiency and tunable electronic structures. However, intrinsic scaling relationships between adsorbed intermediates limit catalytic performance and complicate discovery through conventional machine learning (ML). To overcome this, we combined density functional theory (DFT) with a progressive learning strategy within an active learning framework. By first predicting adsorption energies as auxiliary features, our ML model achieved improved sensitivity to rare, high-activity candidates. High-throughput screening of 261 transition metal single-atom-doped metal oxides (M SA -MO x ) identified nine top-performing catalysts (theoretical overpotential < 0.5 V), including Mn SA -RuO 2 and Fe SA -TiO 2 (theoretical overpotential < 0.3 V). Data mining revealed key theoretical descriptors governing OER activity, while electronic structure analysis pinpointed intermediate binding strength as the key performance driver. Further constant-potential DFT calculations and experimental evaluation of Mn SA -RuO 2 confirmed its low overpotential and excellent durability under acidic conditions. This integrated framework, which connects theoretical modeling, ML prediction, and experimental validation, accelerates the discovery of efficient OER catalysts and provides mechanistic insights for the rational design of materials in sustainable energy technologies.}, archive = {J_ANGEW}, author = {Liangliang Xu and Linguo Lu and Ning Xu and Jinpei Huang and Guorui Li and Jiaqian Wang and Xiaojuan Hu and Alvaro Guerrero and Juan Carlos Vélez Reyes and Xiujuan Xu and Zhong-Kang Han and Zhongfang Chen}, doi = {10.1002/anie.202510965}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510965}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Progressive learning-guided discovery of single-atom metal oxide catalysts for acidic oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). A guest cation screening principle for enabling customized Cathode/Electrolyte interface chemistry and self-enhanced aqueous zinc-ion batteries. ANGEW, 64(36), e202510893. (www)

  @article{ , abstract = {Intrinsic structural instability and sluggish reaction kinetics at the electrode/electrolyte interface are two critical concerns that block the application of MnO 2 cathode in high-performance aqueous zinc-ion batteries. This work proposes a theoretical screening principle to select the compatible guest cation for MnO 2 host, not only to strengthen the structure but also customize high-efficiency cathode/electrolyte interphase (CEI). As identified, Sr 2+ is selected as the suitable intercalation ion that enable in situ forming the SrSO 4 CEI after partial release upon charge process. Moreover, density functional theory calculation and multiple characterization research indicate that such SrSO 4 interphase shows an electronic insulation to stabilize the interfacial pH, inhibit the Mn dissolution, and promote the efficient de-solvation of hydrated zinc ions. Benefited from the self-optimizing cathode/electrolyte interface chemistry, the 2.5% Sr-MnO 2 one exhibits higher specific capacity (304.1 mAh g −1 at 0.5 A g −1 ), better rate capability (115 mAh g −1 at 10 A g −1 ), as well as higher capacity retention of 87.9% after 1000 cycles at 2 A g −1 , when compared with pure δ-MnO 2 electrode. This study provides a new insight on understanding the functions of ion intercalation engineering to design robust layered cathode for high-performance aqueous zinc-ion batteries and beyond.}, archive = {J_ANGEW}, author = {Meiqi Yang and Jianhui Zhu and Jing Lin and Longjun He and Minfeng Chen and Yanyi Wang and Jizhang Chen and Shengkui Zhong and Hongwei Mi and Chuanxin He and Dingtao Ma and Peixin Zhang}, doi = {10.1002/anie.202510893}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A guest cation screening principle for enabling customized Cathode/Electrolyte interface chemistry and self-enhanced aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Is a malleable active site loop the key to high substrate promiscuity? hybrid, biocatalytic route to structurally diverse taxoid side chains with remarkable dual stereocontrol. ANGEW, 64(36), e202510889. (www)

  @article{ , abstract = {These studies reveal the first structure of Clostridium acetobutylicum alcohol dehydrogenase (CaADH), a protein exhibiting remarkable substrate promiscuity and stereochemical fidelity. The CaADH enzyme is utilized here for synthesizing 20 potential aryl isoserine side chains for the Taxotere family of tubulin-binding chemotherapeutics. The approach involves dynamic reductive kinetic resolution (DYRKR) upon the corresponding α-chloro-β-keto esters, showing high D- syn stereoselectivity, including those leading to the clinically relevant milataxel (Ar = 2-furyl) and simotaxel (Ar = 2-thienyl) side chains. Furthermore, various cross-coupling chemistries performed on the p -bromophenyl isoserine side chain significantly enhance the structural diversity of the taxoid side chain library obtained (16 additional taxoid side chains). The CaADH structure is notable: (i) the nicotinamide cofactor is bound in an anti- conformation, with the amide carbonyl occupying the ketone binding pocket, and (ii) a flexible loop near the active site likely contributes to the remarkable substrate promiscuity observed in CaADH. We present our perspective on the dynamic nature of the CaADH active site through molecular dynamics simulation, proposing a halogen bonding model as a potential mechanism for the remarkable selectivity for an ( S )-configured C─Cl bond, in addition to the D-facial selectivity, demonstrated across 20 diverse substrates by this remarkable short-chain dehydrogenase enzyme.}, archive = {J_ANGEW}, author = {Gaurav P. Kudalkar and Florian Leidner and Nivesh Kumar and Jared L. Hass and Peter Madzelan and Douglas R. Powell and Victor W. Day and Pierre Le Magueres and Joseph D. Ferrara and Lee M. Daniels and Akihito Yamano and Sho Ito and Wei Niu and Helmut Grubmüller and Mark A. Wilson and David B. Berkowitz}, doi = {10.1002/anie.202510889}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510889}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Is a malleable active site loop the key to high substrate promiscuity? hybrid, biocatalytic route to structurally diverse taxoid side chains with remarkable dual stereocontrol}, volume = {64}, year = {2025}, }
• (2025). Assessing fluorosulfonyl pentafluorooxosulfate (FSO2–OSF5) reservoir capacity: Selective SOF4, SO2F2, and [OSF5]– anion release. ANGEW, 64(36), e202510796. (www)

  @article{ , abstract = {Herein, the investigation of inorganic reagents containing the pentafluorooxosulfate (OSF 5 ) moiety is presented. First, the gram-scale preparation of the reactive yet stable pentafluorosulfur hypofluorite (FOSF 5 ) as well as its spectroscopic data are reported. Then, the preparation and full characterization of the corresponding fluorosulfonyl pentafluorooxosulfate (FSO 3 SF 5 , FSPO ) by the fluoro-pentafluorooxosulfanylation of SO 2 are highlighted. This liquid reagent (b.p. 39.6 °C) was later successfully used for modulable release of [cat][OSF 5 ] ion-pair. The selective, in-solution release of SOF 4 and SOF 4 /SO 2 F 2 species was also demonstrated. Finally, the SuFEx reactivity was investigated and showed interesting reservoir ability. Indeed, we report the one-pot synthesis of sulfonyl fluoride (-SO 2 F) and sulfurimidoyl fluoride (─N═S(O)F 2 ) species.}, archive = {J_ANGEW}, author = {Alexandre Millanvois and Carlota Bahri and Thomas Drews and Simon Steinhauer and Sebastian Riedel}, doi = {10.1002/anie.202510796}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510796}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Assessing fluorosulfonyl pentafluorooxosulfate (FSO2–OSF5) reservoir capacity: Selective SOF4, SO2F2, and [OSF5]– anion release}, volume = {64}, year = {2025}, }
• (2025). A robust nickel-interlocked π-conjugated covalent organic framework catalyst for photocatalytic aromatic finkelstein and retro-finkelstein reactions. ANGEW, 64(36), e202510788. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) are emerging as a versatile class of hosts for heterogeneous photocatalysis. Herein, we present a nickel-decorated pyrene- and bipyridine-based olefin-linked COF ( Ni@COF1 ) as a robust and recyclable catalyst for visible-light-driven aromatic Finkelstein and retro-Finkelstein reactions. The extended π-conjugation within the COF framework enhances light absorption, promotes charge transport, and facilitates in situ Ni(0) generation from the pre-installed Ni(II) centers. Compared to its reduced counterpart ( Ni@COF1R ), Ni@COF1 exhibits remarkable catalytic performance. The methodology enables selective halide exchange, broad functional group compatibility, and late-stage diversification of eight bioactive molecules and nine pharmaceutical motifs. Furthermore, a gram-scale reaction with batch and continuous flow conditions underscores its scalability and synthetic utility. The catalyst is robust and recycled five times without any loss of catalytic activity, reaching a total turnover number >850. These results highlight the significance of olefin-linked COFs in advancing sustainable photocatalysis and expanding their role in fine chemical synthesis.}, archive = {J_ANGEW}, author = {Ayan Jati and Suranjana Dam and Tuhin Suvra Khan and Biplab Maji}, doi = {10.1002/anie.202510788}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510788}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A robust nickel-interlocked π-conjugated covalent organic framework catalyst for photocatalytic aromatic finkelstein and retro-finkelstein reactions}, volume = {64}, year = {2025}, }
• (2025). A highly crystalline 2D conjugated Metal–Organic framework for superior sodium storage. ANGEW, 64(36), e202510698. (www)

  @article{ , abstract = {Two-dimensional conjugated metal–organic frameworks (2D c -MOFs) have emerged as promising electrode materials for sodium-ion batteries (SIBs). However, developing 2D c -MOFs with multiple redox-active sites and well-defined structures to enhance the performance of SIBs and elucidate the structure–property relationship remains challenging. Herein, a 2D c- MOF single crystal (Cu-TBP) with dual active centers was synthesized using an octahydroxyl tetrabenzophenazine (8OH-TBP) ligand. Three-dimensional electron diffraction (3D ED) analysis reveals the atomic-level crystal structure of Cu-TBP, characterized by a planar 2D rhombus network and a unique slipped AA layer-stacking. Cu-TBP exhibits typical semiconducting behavior with a high electrical conductivity (7.69 × 10 −3 S m −1 at 298 K) and a low thermal activation energy. Owing to its abundant redox-active sites and superb electrical conductivity, Cu-TBP shows remarkable electrochemical performance as a SIB anode, achieving a high reversible capacity of 369.7 mAh g −1 at 0.25 A g −1 , exceptional rate capability, and extraordinary cyclability (82.6% capacity retention after 800 cycles at 0.25 A g −1 ). Experimental studies combined with theoretical calculations further elucidate the Na + storage mechanism.}, archive = {J_ANGEW}, author = {Jia-Cheng Yin and Xin Lian and Jinli Zhang and Zhi-Gang Li and Ming Liu and Jiandong Pang and Wei Li and Yunhua Xu and Na Li and Xian-He Bu}, doi = {10.1002/anie.202510698}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly crystalline 2D conjugated Metal–Organic framework for superior sodium storage}, volume = {64}, year = {2025}, }
• (2025). Realizing unconventional tandem nitrate reduction for efficient ammonia electrosynthesis enabled by co, fe dual-site conjugated metal organic frameworks. ANGEW, 64(36), e202510665. (www)

  @article{ , abstract = {The electrochemical nitrate-to-ammonia reduction reaction (NO 3 RR) offers a sustainable route for carbon-neutral chemical synthesis, while the intricate multi-electron/proton transfer processes and unstable intermediates pose significant challenges in attaining high selectivity and efficiency. This study demonstrates a Co, Fe bimetallic conjugated metal organic frameworks (CoFe-cMOFs) that enable efficient NO 3 RR via an unconventional [6 + 2] electron-transfer tandem pathway. Unlike the traditional [2 + 6] tandem pathway, the Fe sites predominantly reduce NO 3− to *NH 2 OH intermediate, which subsequently spills over onto the Co sites for further protonation. This unconventional tandem pathway effectively avoids the release of NO 2− and guarantees selective NH 3 production. The CoFe-cMOFs achieve 94.3% NH 3 -producing Faradaic efficiency with a yield rate of 14.1 mg h −1 cm −2 in neutral electrolyte. The Zn-NO 3 − battery prototype incorporating CoFe-cMOFs exhibits 3.6 mW cm −2 peak power density with stable NH 3 production. This work proposes a mechanistic breakthrough in tandem pathway regulation for selective electrochemical ammonia synthesis.}, archive = {J_ANGEW}, author = {Shengji Tian and Runjie Wu and Hengjie Liu and Chunshuang Yan and Zeming Qi and Pin Song and Wen-Jie Chen and Li Song and Zheng Wang and Chade Lv}, doi = {10.1002/anie.202510665}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510665}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Realizing unconventional tandem nitrate reduction for efficient ammonia electrosynthesis enabled by co, fe dual-site conjugated metal organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Robust imidazole-linked 2D covalent organic frameworks for efficient electrochemical sodium-ion storage. ANGEW, 64(36), e202510604. (www)

  @article{ , abstract = {Exploring stable and functional linkages through facile one-pot cyclocondensation reactions represents one of the frontiers in the development of covalent organic frameworks (COFs), which can enhance structural robustness and diversity while broadening their application potential. In this study, we report a facile synthetic strategy using p -toluenesulfonic acid (PTSA) as a proton mediator to construct two imidazole-linked COFs (TABQ-COF and TAPT-COF) via one-pot cyclocondensation of aromatic aldehydes with ortho -diamines. These two COFs not only possess good crystallinity but also exhibit excellent physicochemical stability and contain abundant redox-active sites, which endows them with charming advantages for electrochemical energy storage. Remarkably, when employed as an anode material for sodium-ion batteries (SIBs), TAPT-COF delivered a reversible capacity of 517 mAh g −1 at 0.05 A g −1 while maintaining outstanding cycling stability with minimal capacity degradation (<0.035% per cycle) over 1000 cycles at 1.0 A g −1 . This superior performance stems from synergistic contributions of abundant redox-active centers (C═O and C═N groups), which enable efficient Na + storage through multielectron redox mechanisms. This study highlights the strategic advantage of structurally stable COFs with precisely engineered redox-active motifs via facile synthesis for advancing high-performance electrochemical energy storage.}, archive = {J_ANGEW}, author = {Yuzhao Guo and Linqi Cheng and Xupeng Zhang and Meiling Qi and Yabo Wei and Sheng Han and Xi Su and Heng-Guo Wang and Long Chen}, doi = {10.1002/anie.202510604}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510604}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust imidazole-linked 2D covalent organic frameworks for efficient electrochemical sodium-ion storage}, volume = {64}, year = {2025}, }
• (2025). Molecular rotors as reactivity probes: Predicting electrophilicity from the speed of rotation. ANGEW, 64(36), e202510556. (www)

  @article{ , abstract = {A new empirical electrophilicity reactivity parameter, E RB , was developed based on the rotational barriers of a series of N -phenylimide molecular rotors containing various electrophilic groups. In the bond rotation transition state, these electrophilic groups form close contact with an electronegative C═O oxygen. Thus, strong electrophilic groups significantly lowered the rotational barrier. As a result, the rotational barriers were inversely correlated with the strengths of the electrophiles. The rotational barriers were measured by dynamic NMR (EXSY), enabling the quantification across a wide range of types of electrophiles. Computational analysis confirmed that the observed variations arose from intramolecular interactions in the transition state, where the C═O oxygen served as a probe of both the electrophilic group's electrostatic potential and steric accessibility. By simultaneously capturing attractive and repulsive transition state interactions, E RB provides an effective means of predicting electrophilicity and reactivity trends across a broad range of electrophiles and reaction types. The utility of E RB was initially validated using a series of rotors containing Michael addition electrophiles, followed by broader application to a diverse array of reactions involving sp 3 and sp 2 electrophiles, including S N 2, S N Ar, Pd-oxidative addition, and Sonogashira reactions.}, archive = {J_ANGEW}, author = {Hao Liu and Xiaolong Huang and Binzhou Lin and Harrison M. Scott and Ishwor Karki and Erik C. Vik and Perry J. Pellechia and Ken D. Shimizu}, doi = {10.1002/anie.202510556}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510556}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular rotors as reactivity probes: Predicting electrophilicity from the speed of rotation}, volume = {64}, year = {2025}, }
• (2025). Advancing solid-state calcium batteries: Achieving fast ionic conductivity at near ambient conditions in calcium hydridoborates. ANGEW, 64(36), e202510493. (www)

  @article{ , abstract = {All-solid-state batteries based on abundant elements, such as calcium, offer a promising route to safer, cheaper, and more sustainable energy storage. Here, we report a series of fast Ca 2+ -conducting compounds of methylamine calcium tetrahydridoborates, Ca(BH 4 ) 2 · x CH 3 NH 2 (0 < x < 4.9) and related nanocomposites stabilized by inert MgO nanoparticles. Three new crystal structures are identified: a three-dimensional network of octahedrally coordinated Ca 2+ complexes for x = 1, a molecular structure of neutral complexes for x = 4, and a structure of cationic complexes for x = 6. The thermal stability generally decreases with increasing CH 3 NH 2 content, and samples with x > 2 slowly release CH 3 NH 2 in “open” atmosphere at room temperature, but are stabilized in “closed” environments, e.g. capillaries. The ionic conductivity increases with CH 3 NH 2 content and correlates with increased void space and structural flexibility, reaching σ (Ca 2+ ) = 5.0·10 −5 S cm −1 at 60 °C for x = 4. Moreover, the effect of nanocomposite formation provides mechanical stability and a doubling of the ionic conductivity for Ca(BH 4 ) 2 ·4CH 3 NH 2 − MgO (50 wt%), reaching σ (Ca 2+ ) = 1.3·10 −4 S cm −1 at 60 °C. These findings demonstrate how local structure and nanoscale interfacial effects govern calcium transport, offering new design principles for functional calcium solid electrolytes.}, archive = {J_ANGEW}, author = {Jakob B. Grinderslev and Lasse N. Skov and Lasse R. Kristensen and Torben R. Jensen}, doi = {10.1002/anie.202510493}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Advancing solid-state calcium batteries: Achieving fast ionic conductivity at near ambient conditions in calcium hydridoborates}, volume = {64}, year = {2025}, }
• (2025). Light-induced fe-LMCT catalysis for redox-coupled conversion of NOx and SO2 mixture. ANGEW, 64(36), e202510456. (www)

  @article{ , abstract = {The coexistent nitrogen oxides (NO x ) and sulfur dioxide (SO 2 ) in flue gas pose inherent challenges for simultaneous removal due to their disparate reactivities. Conventional sequential treatments for their simultaneous removal face major issues of catalyst deactivation and byproduct generation. Here, we develop a subtle strategy using light-induced ligand-to-metal charge transfer (LMCT) catalysis with Fe(II) ethylenediaminetetraacetic acid (EDTA-Feᴵᴵ) to achieve redox-coupled conversion of NO and SO 2 mixtures. LMCT excitation in EDTA-Fe II induces directional charge separation under irradiation, routing photogenerated electrons (e⁻) to Feᴵᴵ for driving selective NO-to-N 2 conversion (selectivity: 99.89%), while photogenerated holes (h + ) oxidize SO 2 to SO 4 2 ⁻ (selectivity: 96.34%). This spatial segregation of redox pathways suppresses N 2 O generation, enabling continuous operation with 90.3% NO and nearly 100% SO 2 removal efficiency. Mechanism studies reveal the LMCT-enhanced charge transfer from carboxyl/amino groups to Fe centers, while in situ EPR confirms the •SO 3 2 ⁻ radical-mediated h + scavenging that accelerates charge separation and utilization. This work establishes Fe-LMCT catalysis as a sustainable platform for gas-phase pollutants remediation, achieving unprecedented selectivity through precise redox pathway control.}, archive = {J_ANGEW}, author = {Ruimin Chen and Jielin Wang and Taobo Huang and Chunling Zhang and Xiuping Zhu and Jieyuan Li and Fan Dong}, doi = {10.1002/anie.202510456}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-induced fe-LMCT catalysis for redox-coupled conversion of NOx and SO2 mixture}, volume = {64}, year = {2025}, }
• (2025). Designing new natural-mimetic phosphatidic acid: A versatile and innovative synthetic strategy for glycerophospholipid research. ANGEW, 64(36), e202510412. (www)

  @article{ , abstract = {Glycerophospholipids (GPLs) play important roles in cellular compartmentalization and signaling. Among them, phosphatidic acids (PA) exist as many distinct species depending on acyl chain composition, each one potentially displaying unique signaling function. Although the signaling functions of PA have already been demonstrated in multiple cellular processes, the specific roles of individual PA species remain obscure due to a lack of appropriate tools. Indeed, current synthetic PA analogues fail to preserve all the functions of natural PA. To circumvent these limitations, we developed a novel synthetic approach to produce PA analogues without compromising structural integrity of acyl chains. Moreover, addition of a clickable moiety allowed flexible grafting of different molecules to PA analogues for various biological applications. Hence, this innovation also provides powerful tools to investigate specific biological activities of individual PA species, with potential applications in unraveling complex GPL-mediated signaling pathways.}, archive = {J_ANGEW}, author = {Antoine Schlichter and Alexander Wolf and Thomas Ferrand and Aurelien Cocq and Lina Riachy and Steven Vertueux and Brice Beauvais and Marine Courvalet and Paul-Joël Henry and Emeline Tanguy and Louis Gonzales and Rémy Ferlet and Fanny Laguerre and Charles Decraene and Alexia Pellissier and Muriel Sebban and Cyrille Sabot and Lydie Jeandel and Sarah Cianférani and Jean-Marc Strub and Magalie Bénard and Victor Flon and Valérie Peulon-Agasse and Pascal Cardinael and Stéphane Ory and Stéphane Gasman and Pierre-Yves Renard and Maïté Montero-Hadjadje and Nicolas Vitale and Sébastien Balieu}, doi = {10.1002/anie.202510412}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510412}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Designing new natural-mimetic phosphatidic acid: A versatile and innovative synthetic strategy for glycerophospholipid research}, volume = {64}, year = {2025}, }
• (2025). Catalytic polymerization of n-doped poly(benzodifurandione) (n-PBDF) using parts per million (ppm) levels of molybdenum trioxide. ANGEW, 64(36), e202510411. (www)

  @article{ , abstract = {The recent discovery of highly conductive, solution-processable, n-doped poly(benzodifurandione) (n-PBDF) has significantly pushed the boundaries of organic electronics. However, to maximize its practical impact, an efficient, scalable and cost-effective synthetic method is essential. Initially, n-PBDF was synthesized via duroquinone-mediated or copper-catalyzed polymerizations, but these methods required prolonged dialysis, limiting their scalability. Our recent SeO 2 -catalyzed polymerization improved efficiency but still necessitated centrifugation and filtration to remove solid selenium byproducts. In this work, we introduce a highly efficient molybdenum trioxide (MoO 3 )-catalyzed polymerization of n-PBDF. Remarkably, MoO 3 at parts-per-million (ppm) concentrations achieves near-quantitative monomer conversion (>99% by NMR), eliminating the need for purification. Kinetic studies demonstrate that this polymerization follows a chain-growth mechanism, enabling the synthesis of high-quality n-PBDF polymers with controlled particle sizes and block copolymers. Mechanistic investigations reveal that MoO 3 mediates an oxidative pathway involving dimethyl sulfoxide (DMSO), with dimethyl sulfide (DMS) identified as the reduction product. This innovation not only provides a scalable, low-cost route to high-quality n-PBDF but also unlocks new synthetic opportunities, significantly expanding the synthetic toolbox for functional polymers.}, archive = {J_ANGEW}, author = {Guangchao Liu and Uttam Pal and Sanket Samal and Michael F. Espenship and Yuanhe Li and Won-June Lee and Lawal Adewale Ogunfowora and Liyan You and Julia Laskin and Jianguo Mei}, doi = {10.1002/anie.202510411}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510411}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic polymerization of n-doped poly(benzodifurandione) (n-PBDF) using parts per million (ppm) levels of molybdenum trioxide}, volume = {64}, year = {2025}, }
• (2025). Polymorphic α-glucans as structural scaffolds in cryptococcus cell walls for chitin, capsule, and melanin: Insights from 13C and 1H solid-state NMR. ANGEW, 64(36), e202510409. (www)

  @article{ , abstract = {Cryptococcus species are major fungal pathogens responsible for life-threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi are distinguished by a distinctive cell wall architecture further reinforced by two virulence-associated layers, melanin and capsule, rendering them insensitive to antifungal agents targeting the cell wall, such as echinocandins. The molecular interplay between these three biomolecular layers remains poorly understood. Here, we employ solid-state NMR spectroscopy to examine intact cells of both wild-type and capsule-deficient strains of C. neoformans , along with melanized cells. High-resolution 13 C and 1 H data revealed five distinct structural forms of α-1,3-glucans that play versatile roles in forming the rigid cell wall scaffold by interacting with chitin microfibrils and chitosan, and in stabilizing the mobile matrix by associating with β-1,6-glucan and a small fraction of β-1,3-glucan. Two primary forms of α-1,3-glucans were distributed throughout the wall, capable of hosting melanin deposition in the inner domain and capsule attachment on the cell surface. These findings offer a paradigm shift in understanding the cryptococcal cell wall and its interaction with two key virulence factors on opposite sides, raising critical biochemical questions that could inform the development of more effective antifungal treatments for cryptococcosis.}, archive = {J_ANGEW}, author = {Ankur Ankur and Jayasubba Reddy Yarava and Isha Gautam and Faith J. Scott and Frederic Mentink-Vigier and Christine Chrissian and Li Xie and Dibakar Roy and Ruth E. Stark and Tamara L. Doering and Ping Wang and Tuo Wang}, doi = {10.1002/anie.202510409}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510409}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polymorphic α-glucans as structural scaffolds in cryptococcus cell walls for chitin, capsule, and melanin: Insights from 13C and 1H solid-state NMR}, volume = {64}, year = {2025}, }
• (2025). Stretch-induced structural ordering and orientation for tensile yield behavior and anisotropic optical property of molecular granular materials. ANGEW, 64(36), e202510392. (www)

  @article{ , abstract = {The densely packed sub-nm particles, molecular granular materials (MGMs), represent a new class of functional materials that deliver distinct mechanical properties from polymers and conventional granular materials. However, their costly synthesis and the vague understanding of their mechanical property hinder extensive progress. Herein, the supramolecular complexation approach is developed for the feasible construction of MGMs with hierarchical structures, while in situ small angle X-ray scattering (SAXS) is applied to monitor the mechanical deformation of MGMs for microscopic understanding. Amphiphilic oligomers are assembled from the ionic attraction of 1 nm molecular clusters and further pack into ordered hexagonal phases (HEX1) driven by hydrophobic interaction. Interestingly, stretching can induce structural orientation, and thus triggering the transformation of HEX1 to another hexagonal phase (HEX2) with denser packing, accounting for the tensile yield behavior of the MGMs. The supramolecular structure endows hierarchical structure relaxation dynamics, enabling their unique viscoelasticity with a resilient rubbery plateau even at high temperatures. Their flexibility renders the capability to facilely process the MGMs into highly oriented films and coatings with anisotropic properties for potential applications in optical device fabrications.}, archive = {J_ANGEW}, author = {Wei Liu-Fu and Shengqiu Liu and Jiadong Chen and Jia-Fu Yin and Panchao Yin}, doi = {10.1002/anie.202510392}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510392}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stretch-induced structural ordering and orientation for tensile yield behavior and anisotropic optical property of molecular granular materials}, volume = {64}, year = {2025}, }
• (2025). Amorphous nitride-chloride solid-state electrolytes for high performance all-solid-state lithium batteries. ANGEW, 64(36), e202510359. (www)

  @article{ , abstract = {High-performance solid-state electrolytes (SSEs) are crucial for advancing all-solid-state batteries (ASSBs). Amorphous SSEs, in particular, offer promising advantages due to their grain-boundary-free nature, which facilitates intimate solid-to-solid contact and uniform lithium-ion flux, thereby improving composite electrode performance. Here, we report a class of SSEs based on a nitrogen–chlorine dual-anion framework, formulated as Li 3 x +0.1 ZrN x Cl 4.1 , for high-voltage ASSBs. Unlike widely studied crystalline Li 2 ZrCl 6 with a triclinic structure, increased N 3− substitution drives a structural transition to an amorphous phase (Li 1.3 ZrN 0.4 Cl 4.1 ), which achieves a significant enhancement in Li + conductivity from 0.46 to 3.01 mS cm −1 , alongside improved oxidative stability up to 4.8 V. This dual-anion SSEs exhibits excellent compatibility with high-energy LiNi 0.83 Co 0.06 Mn 0.11 O 2 (NCM83) cathodes. The corresponding full cells deliver a high reversible capacity of 200.1 mAh g −1 at 4.5 V with outstanding capacity retention of 95.1% after 150 cycles at 0.2 C, along with remarkable long-term cycling stability exceeding 3000 cycles at 3 C. Furthermore, the electrochemical stability of Li 1.3 ZrN 0.4 Cl 4.1 in conjunction with NCM83 is still preserved under elevated temperatures (50  °C) and higher cut-off voltages (up to 4.8 V). These results highlight the promise of dual-anion amorphous electrolytes, paving the way for the design of next-generation SSEs beyond traditional single-anion systems.}, archive = {J_ANGEW}, author = {Ting-Ting Wu and Si-Jie Guo and Hong-Shen Zhang and Yue Jiang and Jun Wang and Jiacheng Zhu and Xusheng Zhang and Pengfei Wei and Ziyang Hu and Rongzhi Gao and GuanHua Chen and Rui Wen and Xuefeng Wang and An-Min Cao}, doi = {10.1002/anie.202510359}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510359}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amorphous nitride-chloride solid-state electrolytes for high performance all-solid-state lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Conduction band convergence and modular nanostructures: Driving high thermoelectric performance in n-type PbSe. ANGEW, 64(36), e202510305. (www)

  @article{ , abstract = {n -type lead chalcogenides showing high thermoelectric performance are rare due to the larger energy offset between the two lowest energy conduction bands minima, leaving ample opportunity to modulate electronic structure for improving their thermoelectric performance. Here, we present a remarkable thermoelectric figure of merit (zT) of ∼1.8 at 873 K in n -type PbSe doped with MoCl 5 by modulation of the conduction bands, while simultaneously suppressing the phonon transport. Doping MoCl 5 in PbSe induces notable convergence of conduction bands and an increased density of states near the Fermi level, mainly due to the contribution of Mo 4 d orbital hybridized with the Se 4 p -Pb 6 p . This results in an improved Seebeck coefficient, despite maintaining a high n -type charge carrier concentration resulting in an excellent power factor (σS 2 ) of ∼21 µW cm −1 K −2 at 873 K for PbSe + 1 mol% MoCl 5 . When the solid solution limit of the doping exceeds, it forms unique modular nano-heterostructures (5-30 nm) of PbSe-MoSe 2 misfit layered compounds embedded in PbSe matrix. These nano-heterostructures significantly intensify phonon scattering, leading to an ultralow lattice thermal conductivity (κ lat ) of 0.20 W m −1 K −1 at ∼725 K in PbSe + 1 mol% MoCl 5 sample.}, archive = {J_ANGEW}, author = {Indrajit Haldar and Vaishali Taneja and Naveen Goyal and Mohammad Ubaid and Debattam Sarkar and Dinesh Kumar Kedia and Kumar Saurabh and Surjeet Singh and Koushik Pal and N. Ravishankar and Kanishka Biswas}, doi = {10.1002/anie.202510305}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510305}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conduction band convergence and modular nanostructures: Driving high thermoelectric performance in n-type PbSe}, volume = {64}, year = {2025}, }
• (2025). Biocatalytic alkylation of ambident nucleophiles enables selective N-functionalization of heterocycles and late-stage modifications. ANGEW, 64(36), e202510300. (www)

  @article{ , abstract = {The alkylation with electrophilic haloalkanes is a key methodology in chemical synthesis to build desired molecules. Although alkylation of compounds bearing a single nucleophilic site is routine, the selective alkylation of polyfunctional molecules with multiple competing nucleophilic positions of comparable reactivity is often very challenging. In this work, we report a generalizable solution for selective alkylation chemistry that combines the selectivity of enzyme catalysis with the reactivity of off-the-shelf alkylation reagents. We employ engineered transferases in a modular cyclic cascade and use functionalized N -heteroarenes as challenging proof-of-concept substrates. This catalytic alkylation approach is mild, highly chemo- and regioselective, proceeds on gram-scale, provides rapid access to important N -alkylated heterocyclic building blocks and enables challenging late-stage alkylations. This study demonstrates a generalizable strategy to streamline synthetic routes to many pharmaceutically important compounds by selective biocatalytic alkylation of polyfunctional molecules and ambident nucleophiles.}, archive = {J_ANGEW}, author = {Felipe Ospina and Kai H. Schülke and Marius Schnutenhaus and Alina Klein and Om Desai and Shubhanshu Jain and Christine Krofta and Lukas Stratmann and Jianing Yang and Harald Gröger and Stephan C. Hammer}, doi = {10.1002/anie.202510300}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510300}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biocatalytic alkylation of ambident nucleophiles enables selective N-functionalization of heterocycles and late-stage modifications}, volume = {64}, year = {2025}, }
• (2025). Simultaneous manipulation of electric double layer and zn (100) deposition enabled by anions for highly stable zn anodes. ANGEW, 64(36), e202510252. (www)

  @article{ , abstract = {Controlling the growth orientation of zinc (Zn) is an effective method of stabilizing Zn anodes. Although Zn (100) exhibits faster Zn electroplating/stripping kinetics than Zn (002), its high chemical reactivity results in susceptibility to water-induced side reactions. Herein, a two-pronged electrolyte engineering strategy is proposed to enhance the reversibility of Zn anodes, that is, modulating vertically oriented Zn (100) plating while simultaneously constructing a water-poor electrical double layer (EDL). Mechanistic studies revealed that the difluoro(oxalato)borate (DFOB − ) anions of sodium-difluoro(oxalato)borate (NaDFOB) function as a Zn 2+ trapping agent at the inner Helmholtz layer, displacing active water molecules and inducing the preferential deposition of Zn on the Zn (100) crystal facets, thus effectively inhibiting both side reactions and dendrite growth. Consequently, a symmetrical cell with the ZnSO 4 /NaDFOB electrolyte exhibited a long lifetime of over 950 h under severe conditions of 10 mA cm −2 and 5 mAh cm −2 . Furthermore, a practical Zn||NH 4 V 4 O 10 pouch cell could achieves a high capacity of 156 mAh at industrial-level mass loading of 16.6 mg cm −2 . This work provides insights for achieving stable Zn anodes via electrolyte engineering-triggered crystallographic orientation and EDL regulation.}, archive = {J_ANGEW}, author = {Si Tang and Qingyi Wei and Baoquan Liu and Jinlin Yang and Haizhen Jiang and Yanzeng Ge and Daoxiong Wu and Jing Li and Tianyu Qiu and Hui Zhang and Xinlong Tian}, doi = {10.1002/anie.202510252}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous manipulation of electric double layer and zn (100) deposition enabled by anions for highly stable zn anodes}, volume = {64}, year = {2025}, }
• (2025). Nitrogen adsorption sites with low polarizability for benchmark N2/CH4 separation. ANGEW, 64(36), e202510242. (www)

  @article{ , abstract = {Selective adsorption of N 2 from CH 4 is an industrially promising but challenging process given their similar sizes and physicochemical properties. Herein, we report a robust metal-organic framework (Cu-MFU-4l) featuring open Cu(I) sites of low polarizability for benchmark N 2 /CH 4 separation. The presence of open Cu(I) sites in the framework was confirmed by X-ray absorption spectroscopy (XAS), in situ CO-adsorbed infrared spectroscopy, and X-ray photoelectron spectroscopy (XPS). Gas sorption isotherms revealed that Cu-MFU-4l exhibited a significant difference between N 2 and CH 4 uptakes, resulting in a high N 2 /CH 4 uptake ratio (1.94) and kinetic selectivity (2.20), of which the N 2 /CH 4 uptake ratio was the highest among all MOFs reported to date. Breakthrough experiments confirmed Cu-MFU-4l as the best porous adsorbent hitherto reported for binary N 2 /CH 4 separation, based on the record-high breakthrough selectivity (2.43) and CH 4 productivity (0.47 mmol g −1 ). High-purity CH 4 (99.99%) could also be obtained from ternary and even six-component CH 4 mixtures by a one-step separation process. In situ infrared spectroscopy and computational modeling studies revealed that the open Cu(I) sites could better distinguish N 2 and CH 4 .}, archive = {J_ANGEW}, author = {Feifei Zhang and Zhiwei Zhao and Yating Wang and Xiaomin Li and Xiaowei Bai and Mengyue Lu and Yanjie Wang and Xiaoqing Wang and Libo Li and Jinping Li and Jiangfeng Yang}, doi = {10.1002/anie.202510242}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510242}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitrogen adsorption sites with low polarizability for benchmark N2/CH4 separation}, volume = {64}, year = {2025}, }
• (2025). Selective sieving effect of multi-atomic bismuth interfaces for efficient formate electrosynthesis and evolution at industrial current density. ANGEW, 64(36), e202510206. (www)

  @article{ , abstract = {Constructing multi-atomic interfaces architectures is promising for electrocatalytic CO 2 conversion, yet their synthesis and stability under industrial current densities remain challenging. Herein, multi-atomic Bi interfaces (Bi 0 /Bi δ+ −O moiety) were precisely engineered by embedding atomically dispersed Bi centers, encompassing Bi single atoms and Bi atomic clusters into the substrate of porous Bi 2 O 3-x nanosheets. The composite showcases outstanding CO 2 conversion performance across a wide pH range, attaining remarkable Faradaic efficiency for formate (FE formate ) of 96.48% (at ultralow potential of −0.5 V versus RHE) and 92.26% in alkaline and neutral electrolytes, along with exceptional long-term stability over 150 h. Depending on the designed CH 3 OH electrooxidation catalyst (CuO x /ZnCo(OH) x ) at the anode to couple with CO 2 conversion, symmetrical/asymmetrical electrolyzers were developed. The approach could obtain high-added value products with FE formate >90% at both electrodes, achieving a production rate of 4980 µmol h −1 cm −2 under industrial current density. Combined in situ characterizations and theoretical calculations unravel that multiple atomic interfaces featuring interfacial atomic sieving effects effectively enhance preferential binding of *H and *CO 2 to form *OCHO, while simultaneously suppressing the undesired recombination of hydrogen species into H 2 , rationalizing the high selectivity. Further intermediacy of concentrated formate precursors for subsequent C–N coupling toward urea synthesis, establishing a pathway for sustainable evolution.}, archive = {J_ANGEW}, author = {Mengyang Zhang and Wei Zhu and Zhengyang Liu and Shirui Chen and Dingyang Zhou and Xueqin Mu and Zechao Zhuang and Shengchen Wang and Jiarui Yang and Yapeng Du and Xiang Luo and Qinghua Zhang and Suli Liu and Dingsheng Wang and Zhihui Dai}, doi = {10.1002/anie.202510206}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510206}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective sieving effect of multi-atomic bismuth interfaces for efficient formate electrosynthesis and evolution at industrial current density}, volume = {64}, year = {2025}, }
• (2025). Synergistic covalently and mechanically interlocked polymer. ANGEW, 64(36), e202510140. (www)

  @article{ , abstract = {Integrating different polymer types into a unified system in a thoughtful manner leverages their complementary advantages, providing a promising strategy for developing high-performance materials. Mechanically interlocked polymers (MIPs), characterized by their unique spatial entanglement, exhibit distinctive performance advantages, yet their potential to expand material properties through rational integration with other polymer architectures presents substantial opportunities for continued investigation. Herein, we report a coherent integration of covalent polymers (CPs) and mechanically interlocked polymers through sequential orthogonal polymerizations, developing a novel synergistic covalently and mechanically interlocked polymer (CMIP) featuring both structural stability and force-induced dynamics. Compared to its structurally similar but noninterlocked control sample, CMIP demonstrates markedly enhanced thermomechanical stability and performance recovery, achieving a 93.4% recovery efficiency at 100% strain after just 5 min of rest, in contrast to 59.7% for the control. This remarkable stability and recovery result from the synergistic interplay between the covalent polymer framework and the interlocked structure, which work in tandem to preserve network integrity and enable rapid host−guest reformation. Notably, despite this significant improvement, CMIP retains a comparable damping capacity (91% versus 87%) and material toughness (14.8 versus 15.1 MJ m −3 ), owing to the efficient energy dissipation mechanisms enabled by host−guest dissociation and subsequent sliding motion. This strategy imparts CMIP with unique characteristics, offering a prospective pathway for the development of a diverse array of advanced synergistic materials with enhanced, multifaceted properties.}, archive = {J_ANGEW}, author = {Yi Ding and Yuanhao Wang and Changyao Liu and Jingxi Deng and Shaolei Qu and Yongming Wang and Ruixue Bai and Yuhang Liu and Guoquan Liu and Chuan Yue and Wei Yu and Zhaoming Zhang and Xuzhou Yan}, doi = {10.1002/anie.202510140}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510140}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic covalently and mechanically interlocked polymer}, volume = {64}, year = {2025}, }
• (2025). Versatile halide-pair-driven multicomponent polymerization for library synthesis of sequence-controlled semiconducting dendronized polymers. ANGEW, 64(36), e202510068. (www)

  @article{ , abstract = {Sequence-controlled semiconducting polymers represent a new frontier in organic electronics, where precise molecular sequence directly dictates device performance. However, achieving both high sequence fidelity and structural diversity remains a significant challenge using conventional synthetic protocols. To address this issue, we introduce a versatile halide-pair-driven multicomponent polymerization (MCP) strategy that enables the library synthesis of sequence-controlled semiconducting poly(triarylamine)s (PTAAs). By optimizing halide pairing in conjunction with a rationally designed Buchwald ligand–Pd system featuring catalyst-transfer capability, we achieved efficient sequential cascade aminations, thereby enabling the MCP. The versatility of this strategy was demonstrated through the synthesis of a library of sequence-controlled PTAAs, including dendronized variants, underscoring its potential as a general platform for functional semiconducting material discovery.}, archive = {J_ANGEW}, author = {Hae-Nam Choi and Su-Min Ko and Semin Son and Ji-Su Woo and Hyunwoo Park and Dong Joon Lee and Tae-Lim Choi and Won-Jin Kwak and Hwan Myung Kim and In-Hwan Lee}, doi = {10.1002/anie.202510068}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510068}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Versatile halide-pair-driven multicomponent polymerization for library synthesis of sequence-controlled semiconducting dendronized polymers}, volume = {64}, year = {2025}, }
• (2025). The overlooked dual phosphorescence of lappert's diamino stannylene Sn[N(SiMe3)2]2. ANGEW, 64(36), e202510044. (www)

  @article{ , abstract = {The first stable heavy carbene homologues, the heavy tetrylenes, were reported in 1973 by Lappert and coworkers. These tetrylenes were extensively investigated with respect to ground state reactivity, such as small molecule activation, insertion into σ-bonds, coordination chemistry, materials chemistry, or catalysis. Their photophysical properties remained essentially unexplored. We report that the bright yellow-colored diamino stannylene Sn[N(SiMe 3 ) 2 ] 2 shows thermally activated dual orange/green phosphorescence with microsecond lifetime in fluid solution at room temperature, which has been overlooked for more than 50 years. These unique electronic and photophysical properties are studied in detail by temperature-dependent time-resolved emission and absorption spectroscopy and are corroborated by (time-dependent) density functional theory (DFT) calculations. The mechanism of photochemical radical formation has been disclosed, involving unprecedented stannylene excimers with second-order Jahn–Teller distorted structures. The present study provides new insights toward a rational design of tetrel(II) complexes with long-lived emissive excited states, with Sn[N(SiMe 3 ) 2 ] 2 being the prototype.}, archive = {J_ANGEW}, author = {Philipp Sikora and Robert Naumann and Lukas Sorge and Christoph Förster and Katja Heinze}, doi = {10.1002/anie.202510044}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202510044}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The overlooked dual phosphorescence of lappert's diamino stannylene Sn[N(SiMe3)2]2}, volume = {64}, year = {2025}, }
• (2025). Chiral tin-oxo cluster matrices with fluorophore embedment for multichromatic circularly polarized luminescence. ANGEW, 64(36), e202509996. (www)

  @article{ , abstract = {Tin-oxo clusters, characterized by their well-defined chemical compositions and architectures, are multi-metal aggregates composed of Sn-oxide cores and surface ligands. Chirality, a fundamental characteristic governing biological recognition and signal transduction, remains underexplored in stannate clusters compared to extensively studied precious metal clusters. Herein, three enantiomeric pairs of chiral tin-oxo clusters were constructed using axially chiral 1,1′-bi-2-naphthol (BINOL) ligands. Structural analyses revealed supramolecular helical assemblies mediated by directional C─H···π interactions, while circular dichroism (CD) spectroscopy confirmed their intrinsic chirality. Through in situ doping engineering, non-chiral fluorophores with distinct emission profiles were incorporated during chiral cluster crystallization, yielding composite materials exhibiting circularly polarized luminescence (CPL). The optimized system achieved a maximum dissymmetry factor ( g lum ) of 1.5 × 10 −2 . Mechanistic studies established that the spiral packing of the tin-oxo clusters facilitates stereochemical information transfer to the dyes via the spatial confinement effect. This supramolecular chirality induction paradigm offers new insights into the rational design of multifunctional optical materials.}, archive = {J_ANGEW}, author = {Gui-Xin Yan and Er-Xia Chen and Jin-Xia Yang and Jian Zhang and Qipu Lin}, doi = {10.1002/anie.202509996}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509996}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral tin-oxo cluster matrices with fluorophore embedment for multichromatic circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Highly structure-selective on-surface synthesis of isokekulene versus kekulene. ANGEW, 64(36), e202509932. (www)

  @article{ , abstract = {The role of different facets of metal nanoparticles in steering reaction pathways is crucial for the design of heterogeneous catalysts with superior selectivity. As a prominent class of reactions, transition-metal-catalyzed carbon-hydrogen (C─H) bond activation is widely used for the synthesis of base chemicals, modern organic materials, and pharmaceuticals. Here, we report orthogonal selectivity in intramolecular cyclodehydrogenation of a nonplanar cyclic precursor steered by different facets of a copper single crystal. On the Cu(110) surface, the previously unknown cycloarene isokekulene forms with a high selectivity of 92%, whereas reaction on the Cu(111) surface exclusively yields kekulene (>99%). Combining scanning tunneling microscopy with CO-functionalized tips and density functional theory, we identify two adsorption geometries of the precursor, which react to the respective products. Isokekulene adopts two nonplanar adsorption configurations and exhibits strong molecule-substrate interactions, explaining its preferential formation on Cu(110). This combined in-solution and on-surface synthesis approach represents an alternative route for the highly selective synthesis of molecules that are challenging to synthesize and process via conventional methods.}, archive = {J_ANGEW}, author = {Zilin Ruan and Qitang Fan and Alexander Reichmann and Faming Kang and Tim Naumann and Simon Werner and Olaf Kleykamp and Jose Martinez-Castro and Felix Lüpke and Anja Haags and François C. Bocquet and Christian Kumpf and Serguei Soubatch and Jörg Sundermeyer and Peter Puschnig and F. Stefan Tautz and J. Michael Gottfried and Sabine Wenzel}, doi = {10.1002/anie.202509932}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly structure-selective on-surface synthesis of isokekulene versus kekulene}, volume = {64}, year = {2025}, }
• (2025). Reversible structural oscillation mediates stable oxygen evolution reaction. ANGEW, 64(36), e202509915. (www)

  @article{ , abstract = {The dynamic dissolution of active species of electrocatalysts suffers severe durability issues, thus limiting practical sustainable electrochemical application despite the enormous strides in the activity. An atomistic understanding of the dynamic pattern is a fundamental prerequisite for realizing prolonged stability. Herein, modeling on NiFe LDHs, multiple operando spectroscopies revealed the structural oscillation of the local [Ni–O 2 –Fe] unit identified a strong dependence on the alternant Fe dissolution and redeposition during the oxygen evolution reaction (OER) process, thus mediating the dynamic stability. At this point, a proof-of-concept strategy with S, Co co-doping was demonstrated to tune structural oscillations. In situ S leaching that alleviates the lattice mismatch suppresses Fe dissolution, while the electron-withdrawing Co as a deposition site promotes Fe redeposition, thus achieving the reversible oscillation of local [Ni/Co–O 2 –Fe] units and dynamic stability. The implementation of the modified NiFe LDH in industrial water electrolysis equipment operated steadily over 800 h (5000-h lifetime obtained by epitaxial method with 10% attenuation) with an energy consumption of 4.05 kWh Nm −3 H 2 @ 4000 A m −2 . The levelized cost of hydrogen of US$ 2.315 per kg H2 overmatches the European Commission's target for the coming decade (<US$ 2.5 per kg H2 ).}, archive = {J_ANGEW}, author = {Qunlei Wen and Tianyang Liu and Danji Huang and Yu Lin and Zhenhong Yang and Ruoou Yang and Youwen Liu and Xiaomeng Ai and Jiakun Fang and Yafei Li and Bao Yu Xia and Shijie Cheng and Tianyou Zhai}, doi = {10.1002/anie.202509915}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509915}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversible structural oscillation mediates stable oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). A multistate adaptive system of topologically distinct chiral assemblies. ANGEW, 64(36), e202509903. (www)

  @article{ , abstract = {Biological systems exemplify the extraordinary adaptability of living organisms to their surroundings, demonstrating the capacity to reconfigure their structure, properties, and function in response to specific environmental signals. In this context, the exploration of multistate chemical systems designed to mimic natural counterparts, with the capacity to precisely tailor the structural outcome of an assembly and perform a specific function in response to external triggers, remains largely unexplored. Herein, we present a multistate adaptive system of topologically distinct chiral assemblies obtained from a single amino acid-derived naphthalene diimide component and demonstrate its trigger-responsive properties. Our system yields five distinct supramolecular assemblies across both solution and solid states, achieved by modulation of external factors such as temperature, solvent, concentration, and guest molecules. The work demonstrates the remarkable adaptability of the non-covalent assemblies, revealing their profound sensitivity to external triggers, emphasizing the role of enthalpy and entropy in navigating across complex assembly pathways to and between individual outcomes.}, archive = {J_ANGEW}, author = {Wiktoria Adamska and Grzegorz Markiewicz and Anna Walczak and Gokay Avci and Kim E. Jelfs and Jeremy K. M. Sanders and Artur R. Stefankiewicz}, doi = {10.1002/anie.202509903}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509903}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A multistate adaptive system of topologically distinct chiral assemblies}, volume = {64}, year = {2025}, }
• (2025). Establishing 3d–4d orbital hybridization for efficient photothermal catalytic CO2 hydrogenation. ANGEW, 64(36), e202509855. (www)

  @article{ , abstract = {Photothermal catalytic CO 2 conversion offers a promising way to address the energy and environmental issues; however, the development of self-supporting catalysts with high activity and selectivity remains a great challenge. Here, we report the decoration of PdCo alloy on self-supporting carbon cloth with N-doped carbon arrays (PdCo-NC/CC) for efficient photothermal catalytic methanation. In situ spectra and density function theoretical (DFT) calculations demonstrate that the 3 d -4 d hybridization between Co and Pd enables an increase in the energy level of the dz 2 -5 σ and dyz -2 π* states in the CO/PdCo alloy, thus enhancing the binding strength of the *CO intermediate and accelerating the CO hydrogenation. Specifically, the self-supporting substrate provides highly dispersed metal sites for CO 2 methanation while serving as a photo-to-heat converter to improve the temperature of the reaction system. As a result, PdCo-NC/CC exhibits unprecedented photothermal performance toward CO 2 methanation, delivering a CH 4 generation rate as high as 15.23 mol g metal −1 h −1 and a selectivity of 100% in batch reaction under the irradiation of Xenon lamp without any external thermal source. Moreover, the continuous flow photothermal reaction can be smoothly proceeded over 100 h, demonstrating the high stability of PdCo-NC/CC in CO 2 hydrogenation.}, archive = {J_ANGEW}, author = {Yisi Yang and Fengliang Wang and Wenyuan Lyu and Dawang Tang and Datong Chen and Xin Zhao and Ruiqi Fang and Yingwei Li}, doi = {10.1002/anie.202509855}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509855}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Establishing 3d–4d orbital hybridization for efficient photothermal catalytic CO2 hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Atomic-scale Mott–Schottky analogy in SnCu nanoalloy promote high-efficiency urea electrosynthesis at ultralow potential. ANGEW, 64(36), e202509834. (www)

  @article{ , abstract = {Electrocatalytic urea synthesis from CO 2 and NO 3 − offers a sustainable strategy to address environmental challenges and growing urea demand. However, current systems suffer inefficient C-N coupling due to poor selectivity toward critical C/N-intermediates. Herein, we engineered atomic-scale Mott–Schottky analogy in SnCu nanoalloy to create electron-enriched Cu sites, enabling remarkable urea production through quadruple synergy. Sn 2 Cu delivered exceptional urea yield (28.9 mmol h −1 g cat. −1 ) with 46.7% Faradaic efficiency (FE) in H-cell, while demonstrating practical potential with superior catalytic performance (yield: 72.6 mmol h −1 g cat. −1 , FE: 41.3%, stability: 60 h) at −0.52 V in flow cell. In-situ synchrotron radiation-Fourier transform infrared spectroscopy and theoretical calculations revealed electron-enriched Cu active sites enhanced CO 2 /NO 3 − co-adsorption and *CO coverage, while steering reaction pathway toward *CO-*NHO coupling and suppressing hydrogen evolution, thereby reducing rate-determining step energy barrier and prioritizing C-N coupling. This work develops a structure–adsorption-reactivity framework, providing fundamental guidance for advanced urea electrocatalyst design.}, archive = {J_ANGEW}, author = {Pingyi Feng and Buqi Ke and Shao Wang and Yanxu Chen and Mingyu Cheng and Zechuan Dai and Bocheng Zhang and Yifan Li and Genqiang Zhang}, doi = {10.1002/anie.202509834}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509834}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic-scale Mott–Schottky analogy in SnCu nanoalloy promote high-efficiency urea electrosynthesis at ultralow potential}, volume = {64}, year = {2025}, }
• (2025). Dual-mode strain relief via zinc acetate enables high-efficiency InP quantum dot light-emitting diodes. ANGEW, 64(36), e202509765. (www)

  @article{ , abstract = {Heteroepitaxial shell growth on quantum dots (QDs) is essential for tailoring carrier dynamics but is often hampered by core–shell interface strain, which becomes more prominent in environmentally friendly InP QDs due to their significant size effect. Although post-treatment of InP cores with zinc compounds is a common approach to alleviate interface strain, conventional synthesis methods often fail to achieve effective doping, typically leaving zinc on the core surface rather than within the lattice. Herein, we present a dual-mode strain relief strategy using the small-molecule precursor Zn(Ac) 2 . Its ionic bonding character and low steric hindrance enable efficient Zn doping into the InP core and promote uniform epitaxial shell growth, leading to a 50% reduction in interfacial strain and a near-unity photoluminescence quantum yield in InP QDs. This approach simultaneously addresses two major sources of strain: lattice mismatch between the core and shell and steric hindrance from bulky surface ligands. The fabricated green InP-based QLED achieved a high external quantum efficiency of 26.3% and a current efficiency of 108.3 cd A −1 . We believe this strategy provides a general and scalable strain engineering platform for QDs, with broad applicability across various material systems.}, archive = {J_ANGEW}, author = {Changwei Yuan and Qun Wan and Xinrong Liao and Mengda He and Canan Li and Zhemin Shen and Baoquan Sun and Zan Qu and Long Kong and Liang Li}, doi = {10.1002/anie.202509765}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509765}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-mode strain relief via zinc acetate enables high-efficiency InP quantum dot light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). High h2 recovery properties of carbon molecular sieve membranes with sub-nanometer precision derived from dual cross-linked polyimide precursor. ANGEW, 64(36), e202509756. (www)

  @article{ , abstract = {Energy-efficient purification technologies are essential for advancing a sustainable hydrogen economy. Carbon molecular sieve membranes (CMSMs) have emerged as promising candidates; however, achieving precise sub-Angstrom micropore control and ensuring structural stability remain significant challenges. Here, we introduce a dual cross-linked strategy to engineer microporosity of the resulting CMSMs by utilizing a decarbonylated 3,5-diaminobenzoic acid (DABA)-induced rigid network ( Type A ) in conjunction with a sulfur bond-induced flexible network ( Type B ). The 6F-D-S-CMS membrane exhibits a record-high H 2 permeability of 3464 Barrer with H 2 /CH 4 selectivity of 3807, surpassing the Robeson upper bound. Upon pyrolysis at 850 °C, the 6F-D-S-CMS-850 membrane achieves exceptional selectivity values: H 2 /CH 4 at 6538, H 2 /N 2 at 1634, and H 2 /CO 2 at 149—outperforming most reported CMS membranes. Molecular dynamics simulations revealed that the Type B network suppressed CH 4 adsorption (3.6 cm 3 g −1 versus 6.2 cm 3 g −1 ) and significantly enhanced the small pore volume ratio ( V H2 / V CH4 : 10.3 versus 2.1) during carbonization, thereby eliminating non-selective pathways and reducing inter-skeletal spacing (4.09 Å versus 3.78 Å), which enables precise molecular sieving. This rigid-flexible cross-linked strategy for CMSMs establishes a scalable blueprint for next-generation hydrogen production.}, archive = {J_ANGEW}, author = {Mingwei Cai and Huahui Liang and Fuhui Liang and Meiling Tao and Luxin Sun and Xiaohua Ma and Shiyang Zhang and Yonggang Min}, doi = {10.1002/anie.202509756}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509756}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High h2 recovery properties of carbon molecular sieve membranes with sub-nanometer precision derived from dual cross-linked polyimide precursor}, volume = {64}, year = {2025}, }
• (2025). Radical reactivity of thioimidates for diversified polymeric amidines with tunable properties. ANGEW, 64(36), e202509727. (www)

  @article{ , abstract = {The first reactions of thioimidates under radical-mediated conditions are described along with the delineation of structural factors that impact radical reactivity and possible side reactions. Thioimidate-containing copolymers with methylmethacrylate (MMA) are synthesized through radical-mediated, chain-growth polymerization. These materials serve as a synthetic branch point for facile conversion into amidines by treatment with a weak acid and an external amine. Our approach allows for more diverse amidine structures than have been previously reported in polymers. This chemistry also enables crosslinking to form novel hydrogels with finely tuned acid–base behavior. Subsequent examination of the acid–base properties revealed that these features are preserved across linear, soluble amidine polymers to cross-linked amidine gel polymer architectures.}, archive = {J_ANGEW}, author = {Selin Kinali-Demirci and Serkan Demirci and Jacob Byerly-Duke and Brett VanVeller}, doi = {10.1002/anie.202509727}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509727}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radical reactivity of thioimidates for diversified polymeric amidines with tunable properties}, volume = {64}, year = {2025}, }
• (2025). Fe─N4-anchored carbon layer patched TiO2 cavities to construct an “In-lattice heterojunction” for enhanced photocatalytic nitrogen reduction reactions. ANGEW, 64(36), e202509705. (www)

  @article{ , abstract = {Efficient charge separation and carrier transfer are critical determinants of the performance of photocatalysts for nitrogen reduction reactions (NRR) which are critical for agricultural and chemical industries. In this study, a novel type of heterostructure, termed an “In-Lattice heterojunction”, has been constructed by introducing a Fe─N 4 -anchored carbon layer (Fe─N─C) onto the surface of defective TiO 2 (D-TiO 2 ), as well as implanting it into the cavities of D-TiO 2 . The in-lattice heterojunction, defined as FNCTO, achieves efficient radial carrier transfer along the Ti─C─N─Fe in-lattice atomic channel and greatly promoted N 2 adsorption benefiting photocatalytic NRR. Thus, FNCTO exhibits an excellent photocatalytic N 2 reduct`ion into NH 3 activity (88 µmol g −1 h −1 ), obviously higher than that of Fe─N─C sites on noncavity P25, illustrating the crucial role of cavity patch induced in-lattice heterojunction. This study paves a way for the development of high-performance Fe─N─C atomic photocatalysts based on noncarbon materials.}, archive = {J_ANGEW}, author = {Tian-You Chen and Yi-Ran Ying and Jing Wu and Xuan-He Liu and Hongwei Huang}, doi = {10.1002/anie.202509705}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509705}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fe─N4-anchored carbon layer patched TiO2 cavities to construct an “In-lattice heterojunction” for enhanced photocatalytic nitrogen reduction reactions}, volume = {64}, year = {2025}, }
• (2025). A C-to-B atom swap on coumarins and dibenzolactones. ANGEW, 64(36), e202509674. (www)

  @article{ , abstract = {We report a carbon-to-boron “C-to-B” atom swap reaction to transform readily available coumarins into their isosteric benzoxaborins via a net replacement of the C═O group with a B─OH moiety. These conditions were applied to coumarin natural products and other 6–7-membered lactones (25 examples, 29%–93%). We leverage this methodology to transform a flat polyaromatic hydrocarbon into three-dimensional tribenzo[b.d.f]oxepines through a series of atom-swapping reactions followed by ring expansion via the oxaborin intermediate.}, archive = {J_ANGEW}, author = {Tian You and Quang H. Luu and Junqi Li}, doi = {10.1002/anie.202509674}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509674}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A C-to-B atom swap on coumarins and dibenzolactones}, volume = {64}, year = {2025}, }
• (2025). When bigger is better: Lanthanum complexes of bis(phenoxy-amidine) FAlen ligands as unique catalysts for the isoselective ring-opening polymerization of racemic β-lactones. ANGEW, 64(36), e202509587. (www)

  @article{ , abstract = {Discrete yttrium and lanthanum complexes supported by new bis(phenoxy-amidine) ligands have been prepared in high yields. Some of these so-called FAlen ligands, when coordinated onto the large La 3+ in contrast to the small Y 3+ , can adopt an η 3 coordination mode of both amidine moieties. These La-FAlen complexes, either previously isolated or conveniently prepared in situ, act as highly efficient ROP catalysts of simple and functional β-propiolactones rac -BL R (R = Me, CH 2 O i Pr, CH 2 OSi t BuMe 2 ) under mild conditions, returning the corresponding linear polymers PBL R with high control over the molecular weights and narrow dispersities. More uniquely, when substituents with appropriate bulkiness are installed on the phenoxy and amidine moieties, the polymers all feature high isotacticity ( P m up to 0.93). High activity and isoselectivity are maintained, no matter the nature and polarity of the solvent used.}, archive = {J_ANGEW}, author = {Thanh-Tu Bui and Jérôme Bayardon and Cédric Balan and Thierry Roisnel and Raluca Malacea-Kabbara and Pierre Le Gendre and Evgueni Kirillov and Jean-François Carpentier}, doi = {10.1002/anie.202509587}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509587}, shortjournal = {Angew. Chem. Int. Edit.}, title = {When bigger is better: Lanthanum complexes of bis(phenoxy-amidine) FAlen ligands as unique catalysts for the isoselective ring-opening polymerization of racemic β-lactones}, volume = {64}, year = {2025}, }
• (2025). Dinuclear au(0) complex supported by tridentate P–Mg–P ligands. ANGEW, 64(36), e202509553. (www)

  @article{ , abstract = {Despite significant advances in gold chemistry, the synthesis and stabilization of gold centers in a low oxidation state, particularly dinuclear Au(0) species, remain a considerable challenge. In this work, we report the successful isolation of a novel dinuclear Au(0) complex stabilized by tridentate P–Mg–P ligands. Computational studies demonstrate that the Au(0)–Au(0) σ-bond acts as a two-electron donor to the Mg centers. Reactivity studies further revealed the complex's unprecedented ability to perform two-electron reductions on a range of substrates, akin to the behavior of well-established Mg(I) and Zn(I) dimers.}, archive = {J_ANGEW}, author = {Yafei Li and Tianze Xu and Xinggao Ji and Jie Zeng and Jin Xie and Jing Ma and Congqing Zhu and Qin Zhu}, doi = {10.1002/anie.202509553}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509553}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dinuclear au(0) complex supported by tridentate P–Mg–P ligands}, volume = {64}, year = {2025}, }
• (2025). Tertiary phosphine diversification via photochemical P─C chemoselective cleavage of phosphonium salts. ANGEW, 64(36), e202509549. (www)

  @article{ , abstract = {Differentially substituted phosphines are indispensable in medicines, materials, and catalysis, yet their customizable synthesis, traditionally depending on unstable P─H/halogen reagents, remains formidably challenging. Here, we report a photoredox strategy enabling controllable aryl substitution through chemoselective P─C cleavage. By engineering electron donor-acceptor complexes between phosphonium salts and tertiary amines, this metal-free protocol realizes three consecutive hydrocarbyl exchanges for delivering tri-diverse-aryl phosphines with transition metal contamination elimination and broad functional group tolerance including unprotected amines and hydroxyls, facilitating late-stage modification of drugs/commercial ligands and construction of P,O,S-tridentate architectures and chiral P-stereogenic centers. Mechanistic studies reveal the dynamic pentacoordinated-phosphorane-complex formation nature and the radical-intermediate pathway, while the chemoselectivity originates from different P─C bond strengths. This work establishes a modular and sustainable platform for programming-level precision phosphine engineering.}, archive = {J_ANGEW}, author = {Ziyu Gan and Jiajin Chen and Hailong He and Yun-Yi Zhao and Zhiyan Xue and Ziyang Chen and Lifang Wang and Shuyang Liu and Hao Wang and Hua Fu and Yunhe Jin}, doi = {10.1002/anie.202509549}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509549}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tertiary phosphine diversification via photochemical P─C chemoselective cleavage of phosphonium salts}, volume = {64}, year = {2025}, }
• (2025). Prolonging exciton diffusion length via modulating aggregation structures for binary organic photovoltaics approaching 20% certified efficiency. ANGEW, 64(36), e202509516. (www)

  @article{ , abstract = {The performance of flexible all-polymer organic photovoltaics (OPVs) constrained by low short-circuit current density ( J SC ) and fill factor (FF), resulting in diminished power conversion efficiency (PCE) and compromised mechanical stability. Enhancing the exciton diffusion length ( L D ) is pivotal for improving device parameters, including PCE. However, the underlying mechanisms governing exciton diffusion dynamics, influenced by the aggregation structure of conjugated polymers, remain insufficiently understood. This study employs molecular dynamics simulations to calculate the interchain free energy distribution [Δ G (r)] and strategically modulates the aggregation behavior of the polymer donor PM6 by controlling its molecular weight (MW). Medium-MW PM6 demonstrates optimized aggregation behavior, leading to extended L D and precisely tuned fluid mechanics, which facilitate the formation of a pseudo-planar heterojunction (PPHJ) active layer. These advancements enable PPHJ-based all-polymer flexible devices to achieve a PCE of 18.01%, with notable improvements in J SC and FF, and retain 90.4% of their initial efficiency after 2000 bending cycles. Encouraged by these advantages, a record-breaking efficiency of 20.0% (certified 19.68%) was achieved for eco-friendly, printed OPVs (PM6//L8-BO) with small-area devices (0.0621 cm 2 ), whereas large-area modules (23.60 cm 2 ) reached an efficiency of 15.60%.}, archive = {J_ANGEW}, author = {Jiayou Zhang and Fang Fang and Bending Zhang and Lifu Zhang and Houdong Mao and Lin Wen and Dou Luo and Chongbin Yu and Zhen Yang and Yiwang Chen}, doi = {10.1002/anie.202509516}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Prolonging exciton diffusion length via modulating aggregation structures for binary organic photovoltaics approaching 20% certified efficiency}, volume = {64}, year = {2025}, }
• (2025). Hybrid active sites in coordination polymers enable ampere-level acetylene semihydrogenation in membrane electrode assembly systems. ANGEW, 64(36), e202509501. (www)

  @article{ , abstract = {Electrocatalytic acetylene semihydrogenation in membrane electrode assembly systems promises a sustainable pathway for ethylene production, yet faces challenges in catalyst performance and durability. Herein, we developed a Cu coordination polymer with hybrid sites that synergistically integrate open Cu sites and N-heterocyclic carbenes. These hybrid sites bestow the coordination polymer with acetylene gasophilicity, hydrophobicity toward water, and readily accessible active Cu sites, which energetically facilitate acetylene absorption and vinyl intermediate formation, thereby enabling efficient ethylene production at ampere-level current densities. In a membrane electrode assembly electrolyzer with pure acetylene, this polymeric catalyst achieved high ethylene Faradaic efficiency of 93.1% at −0.5 A cm −2 and 83.3% at −1.0 A cm −2 , with stable operation for 100 h at −0.5 A cm −2 . Notably, even with a 15% coal-derived acetylene at a flow rate of 60 standard cubic centimeters per minute, this catalyst system demonstrated 64.4% ethylene energy efficiency and durable performance over 200 h at −0.5 A. This work advances the design of highly stable and active polymeric catalysts for electrocatalytic acetylene semihydrogenation.}, archive = {J_ANGEW}, author = {Kun Ni and Pengfei Gao and Lei Zhang and Lingfeng Tang and Ran Du and Qian Ren and Qikui Fan and Chunlin Chen and Kun Ma and Sifei Zhuo and Baoliang Zhang}, doi = {10.1002/anie.202509501}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509501}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hybrid active sites in coordination polymers enable ampere-level acetylene semihydrogenation in membrane electrode assembly systems}, volume = {64}, year = {2025}, }
• (2025). Revealing parallel inter- and intra-ligand charge transfer dynamics in [Ru(L)2(dppz)]2+ molecular lightswitch with n K-edge X-ray absorption spectroscopy. ANGEW, 64(36), e202509496. (www)

  @article{ , abstract = {In photoactive metal complexes the localization of photoexcited charges dictates the site of chemical reactivity, but few studies measure the charge redistribution in these systems with spatial precision. Herein, we track the inter- and intra-ligand charge transfer processes that underpin light-driven charge separation in the well-studied “molecular lightswitch” [Ru(bpy) 2 dppz] 2+ (aqueous [Ruthenium II (2,2′-bipyridine)2(dipyrido[3,2-a:2′,3′-c]phenazine)] 2+ [Cl − ] 2 ) by probing the electronic structure of ligand nitrogen atoms in real-time using ultrafast X-ray absorption spectroscopy and first principles calculations. We confirm the localization of excited electron density on the phenazine N atoms of dppz and we newly identify two parallel electron transfer pathways to populate this state. Sub-70 fs electron transfer to the phenazine portion of dppz is observed and attributed to intra-ligand electron transfer following Ru-to-dppz metal-to-ligand charge transfer (MLCT) excitation. This fast charge transfer was not reported in prior ultrafast studies. The slower (ca. 2 ps) charge transfer reported extensively in time-resolved optical absorption and emission studies is reassigned here to inter-ligand electron “hopping” between nearly isoenergetic ligand moieties following Ru-to-bpy MLCT excitation. The results demonstrate much faster charge separation than previously identified in this well-studied system, highlighting how extended azaacene ligand motifs promote the competitive charge transfer processes needed to drive light-driven electron transfer chemistry.}, archive = {J_ANGEW}, author = {Elizabeth S. Ryland and Xinzheng Yang and Douglas Garratt and Wade C. Henke and Abdullah Kahraman and Maxwell Taub and Michael Sachs and Elisa Biasin and Christina Y. Hampton and David J. Hoffman and Giacomo Coslovich and Kristjan Kunnus and Georgi L. Dakovski and Michael W. Mara and Lin X. Chen and Karen L. Mulfort and Xiaosong Li and Amy A. Cordones}, doi = {10.1002/anie.202509496}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing parallel inter- and intra-ligand charge transfer dynamics in [Ru(L)2(dppz)]2+ molecular lightswitch with n K-edge X-ray absorption spectroscopy}, volume = {64}, year = {2025}, }
• (2025). The Diels–Alder reaction as a mechanistic probe for vibrational strong coupling. ANGEW, 64(36), e202509391. (www)

  @article{ , abstract = {Vibrational Strong Coupling (VSC) has recently been reported to alter reaction kinetics. Hypotheses on how it does this have been proposed, but open questions remain regarding the importance of the polarity of the reaction mechanism and of intramolecular vibrational redistribution (IVR), among other factors. We propose the Diels–Alder (DA) reaction as a probe to study chemistry under VSC, owing to the high diversity of its reaction partners. Herein, fixed-width cavities and UV–vis spectroscopy were used to determine the rate constants for the reactions of the diene 1,3-diphenylisobenzofuran (DPIBF) with various dienophiles under different coupling conditions. We investigated the effect of coupling six different solvents and of cooperative coupling of the dienophile through the solvent. Secondly, as the DA reaction can be catalyzed by hydrogen bonding, we investigated how the reaction was influenced by coupling alcohol solvents. Finally, we explored the direct coupling of vibrational modes of the dienophiles, including the stretching mode of the reactive C═C bond. In all cases, no substantial changes to the reaction rate constants were observed among the diverse coupling scenarios explored. This work initiates the use of the DA reaction as a mechanistic platform to understand how VSC changes chemistry and invites further experimental and theoretical studies.}, archive = {J_ANGEW}, author = {Cyprien Muller and Maciej Piejko and Sinan Bascil and Joseph Moran}, doi = {10.1002/anie.202509391}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The Diels–Alder reaction as a mechanistic probe for vibrational strong coupling}, volume = {64}, year = {2025}, }
• (2025). Precision screening and surgical resection of pan-cancer using a tandem-locked NIR-II fluorescent probe with optimized activation efficiency. ANGEW, 64(36), e202509372. (www)

  @article{ , abstract = {The development of fluorescent probes for cancer detection and imaging that balance high sensitivity, precision, and broad applicability remains a significant challenge. Although “dual-locked” probes have been devised to enhance diagnostic accuracy via two biomarkers, most fall short in sensitivity, response time, and generalizability for pan-cancer use. We address these gaps with ACy-H-NTR , a cascaded-activation, doubly quenched NIR-II probe. Engineered to respond to hypoxia and acidity—universal tumor hallmarks—it offers fast response, high sensitivity, and specificity for pan-cancer screening and imaging. In contrast to existing probes, its tandem-locked design ensures robust activation exclusively within pan-tumor microenvironments, effectively reducing false positives and delineating precise diagnostic boundaries. Its NIR-II emission and “activation–retention” mechanism enhance tumor imaging efficacy and effectively tackle issues of rapid clearance and background noise, achieving 4.9-fold higher tumor-to-normal (T/N) ratio than ICG and retaining tumor specificity for over 2 days. In pan-cancer models, it enabled high-contrast imaging (T/N ∼7.8) and precise resection with sub-2 mm margins. Crucially, it differentiates human carcinoma from adjacent tissues with sharp boundaries, confirming clinical potential. By integrating a tandem-locked and doubly quenched design that simultaneously optimizes activation efficiency, NIR-II imaging capabilities, and activation-retention mechanisms, this probe overcomes current limitations to enable precise pan-cancer identification and surgical navigation.}, archive = {J_ANGEW}, author = {Lei Zhou and Cong Hu and Huiling Huang and Haifeng Ge and Zhipengjun Zhang and Wei Cheng and Hongwen Liu and Ronghua Yang}, doi = {10.1002/anie.202509372}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509372}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precision screening and surgical resection of pan-cancer using a tandem-locked NIR-II fluorescent probe with optimized activation efficiency}, volume = {64}, year = {2025}, }
• (2025). Atomic-level design of Acid–Base pairs in oxides for selective catalytic reduction of nitrogen oxides with ammonia. ANGEW, 64(36), e202509362. (www)

  @article{ , abstract = {Selective catalytic reduction of nitrogen oxides (NO x ) with NH 3 (NH 3 -SCR) poses considerable potential in the abatement of NO x emissions. However, the efficient adsorption and speedy reaction of reactants following the specific mechanism in a favorable way is still a challenge for enhancing catalysis. Herein, we propose the strategy aimed at adjusting electronic properties of Ce-O v -W acid–base pairs through constructing oxygen vacancies on Ce/WO x , thereby fostering SCR activity. Experimental and theoretical results reveal that Ce-O v -W acid–base pairs not only provide more Ce 3+ sites for promoting the reactivity of adsorbed NO, but also accelerate the reaction between NH 3 and gaseous NO owing to the generation of W 5+ species with superior surface acidity, which enhance Langmuir–Hinshelwood and Eley–Rideal mechanisms, respectively. Consequently, the designed catalysts achieve over 90% NO x conversion above 250 °C and exhibit higher activity than normal Ce/WO 3 and V/W-TiO 2 commercial catalysts, with anti-poisoning of SO 2 and H 2 O under harsh working conditions, expecting to provide the guidance for promoting de-NO x industrial application.}, archive = {J_ANGEW}, author = {Guoquan Liu and He Zhang and Pengfei Wang and Chao Gao and Zechao Zhuang and Dingsheng Wang and Sihui Zhan}, doi = {10.1002/anie.202509362}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509362}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic-level design of Acid–Base pairs in oxides for selective catalytic reduction of nitrogen oxides with ammonia}, volume = {64}, year = {2025}, }
• (2025). Universal chemical presodiation under air condition for highly stable na-deficient oxide cathodes. ANGEW, 64(36), e202509342. (www)

  @article{ , abstract = {Layered transition-metal oxides have attracted growing attention for sodium-ion batteries (SIBs); however, their application is hindered by low initial coulombic efficiency (ICE) due to Na-deficiency and solid-electrolyte interphase formation. Herein, a universal chemical presodiation pathway is reported with Na-bipyridine dissolved in diethyl ether (Na-Bpy/DEE) for stable Na-deficient P2-Na 2/3 Ni 1/3 Mn 2/3 O 2 (NNMO) electrode under air condition. The strongly electron-withdrawing N-functional groups of Bpy •− radicals endow its air insensitivity, and it reduces the NNMO cathode for compensation of Na + from the weakly solvating DEE. This results in a uniform and robust NaF-rich interface to prevent surface lattice disorder of NNMO, which is caused by local stress, and preserve structure integrity. The presodiated NNMO electrode shows high ICE of 100% and reversible capacity of 158.3 mAh g −1 , and its pouch cell coupled with hard carbon presents high-capacity retention of 95.9% after 200 cycles. This work proposes an industrially feasible presodiation strategy to highly efficient SIBs.}, archive = {J_ANGEW}, author = {Fei Li and Yaohui Huang and Tong Zhang and Zihao Song and Xiangshuai Wei and Fujun Li}, doi = {10.1002/anie.202509342}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509342}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Universal chemical presodiation under air condition for highly stable na-deficient oxide cathodes}, volume = {64}, year = {2025}, }
• (2025). Enhanced nonlinear optical response and self-powered CPL detection in unique Triangular–Tetrahedral chiral Copper(I) halides. ANGEW, 64(36), e202509283. (www)

  @article{ , abstract = {The low-coordination polyhedral architecture of Cu(I)-based chiral metal halides induces significant structural distortions, endowing these materials with remarkable circularly polarized light (CPL) activity and exceptional nonlinear optical (NLO) performance. However, achieving highly selective CPL detection with large dissymmetry factors ( g lum ) in Cu(I)-based chiral metal halides remains a significant challenge. Herein, we prepared 1D chiral ( R / S )-MPZCu 2 Cl 4 (where MPZ is 2-methylpiperazine) halides with the unique triangular–tetrahedral configuration in the noncentrosymmetric cubic P 1 2 11 space group, resulting in substantial structural distortions, which significantly impact nonlinear susceptibility. Consequently, ( R )-MPZCu 2 Cl 4 halide exhibits efficient second harmonic generation (SHG), which is 7.29 times as high as that of KH 2 PO 4 . Additionally, ( R )-MPZCu 2 Cl 4 halide also exhibits remarkable third harmonic generation (THG) response, and g THG-CD is as high as +0.309, which is the first demonstration of THG-based CPL detection in Cu(I)-based metal halides. The self-powered CPL photodetectors based on ( R / S )-MPZCu 2 Cl 4 show high CPL distinguishability at 0 V and further achieve self-powered X-ray detection with excellent low-dose detection and radiation resistance. Our study provides valuable insights into the structure–performance relationship in chiral organic–inorganic hybrid Cu(I) halides, paving the way for next-generation multifunctional optoelectronic devices.}, archive = {J_ANGEW}, author = {Yunlong Bai and Zhi Yang and Qihang Deng and Hongzhao Zan and Sheng Cao and Xinxin Han and Mingjian Yuan and Tong Chang and Ruosheng Zeng}, doi = {10.1002/anie.202509283}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509283}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced nonlinear optical response and self-powered CPL detection in unique Triangular–Tetrahedral chiral Copper(I) halides}, volume = {64}, year = {2025}, }
• (2025). Anionic coordination-regulated metal-organic cages for efficient CO2 photoreduction. ANGEW, 64(36), e202509280. (www)

  @article{ , abstract = {Photocatalytic reduction of carbon dioxide (CO 2 ) provides a promising strategy for producing high-value chemicals and fuels. However, developing high-performance photocatalysts for CO 2 reduction remains a great challenge due to the poor stability of reaction intermediates. Herein, we present an anionic coordination strategy to facilitate the stabilization of intermediates by constructing halogen-coordinated metal-organic cages (MOCs) (Ni 8 L 12 X 4 , X = Cl, Br, I). Theoretical calculations show that the formation of *COOH intermediate is the rate-limiting step and halogen coordination effectively regulates the energy barrier for this reaction. Notably, iodide anions significantly reduce the energy gap between the Ni d and iodide p orbitals, enhancing electron transfer from the Ni center to adsorbed CO 2 and promoting the production of *COOH. As a result, Ni 8 L 12 I 4 demonstrates superior performance with a CO production rate of 2680.23 µ mol g −1 h −1 and 95% selectivity, outperforming Cl- and Br-coordinated Ni MOC by 200- and 5-fold, respectively. This work opens a new coordination engineering strategy for fabricating efficient photocatalysts for CO 2 reduction.}, archive = {J_ANGEW}, author = {Linjing Huang and Liyang Qin and Sijie Wan and Yayu Yan and Shaowen Cao and Jian Zhang and Tianhua Zhou}, doi = {10.1002/anie.202509280}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509280}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anionic coordination-regulated metal-organic cages for efficient CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Synergistic modulation of intermediate adsorption and active hydrogen supply enable pulsed nitrate-to-hydroxylamine electroreduction with nearly 100% faradaic efficiency. ANGEW, 64(36), e202509213. (www)

  @article{ , abstract = {Electrochemical hydroxylamine (NH 2 OH) synthesis from NO x under ambient conditions presents a sustainable alternative to energy-intensive industrial methods, but its selectivity remains limited by unbalanced active hydrogen (H*) supply and intermediate adsorption. Herein, we develop boron-doped amorphous Bi metallene arrays for efficient nitrate-to-NH 2 OH electroreduction. In situ spectroscopy and theoretical calculations reveal that the amorphous structure and B-induced p-sp orbital hybridization modulate the electronic structure, optimizing intermediate adsorption while enhancing H* generation. These synergistic effects collectively reduce the energy barrier of the potential-determining step, significantly improving catalytic activity and selectivity. The catalyst achieves an NH₂OH Faradaic efficiency (FE) of 85.3% at −0.4 V versus reversible hydrogen electrode (RHE). By employing a pulsed potential strategy, the FE further increases to nearly 100%, surpassing most reported counterparts. This work not only proposes a novel catalyst design leveraging amorphous engineering and orbital hybridization but also demonstrates the efficacy of pulsed electrolysis in steering reaction pathways for electrosynthesis.}, archive = {J_ANGEW}, author = {Youwei Sheng and Hao Chen and Jiabing Geng and Hongjie Yu and Kai Deng and Ziqiang Wang and Hongjing Wang and Liang Wang and You Xu}, doi = {10.1002/anie.202509213}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509213}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic modulation of intermediate adsorption and active hydrogen supply enable pulsed nitrate-to-hydroxylamine electroreduction with nearly 100% faradaic efficiency}, volume = {64}, year = {2025}, }
• (2025). Chiral self-sorting of flexible covalent organic pillars for adaptive molecular recognition. ANGEW, 64(36), e202509177. (www)

  @article{ , abstract = {Flexible covalent organic pillars ( flex -COP- n ) are introduced as a family of dual-open-ended nanotubular hosts constructed via dynamic imine condensation between pillararene-derived macrocyclic building blocks and conformationally mobile ─(CH 2 ) n ─ aliphatic linkers. These discrete molecular containers feature well-defined tubular channels capable of adaptive host–guest interactions. The self-assembly process exhibits a pronounced odd–even effect, yielding either enantiomeric or meso duplexes through distinct chiral self-sorting pathways. Host–guest interactions between flex -COP-4 and a series of α,ω-dibromoalkanes were systematically investigated using NMR spectroscopy and single-crystal X-ray crystallography. The resulting inclusion complexes span a continuum of binding modes—from relaxed encapsulation to strained, overpacked assemblies—governed by geometric complementarity and mutual host–guest deformation. These findings highlight the role of conformational flexibility in modulating molecular recognition under nanoscale confinement and establish flex -COP- n as a dynamic platform for mimicking adaptive features of biological receptors.}, archive = {J_ANGEW}, author = {Shengnan Gao and Min Zhang and Yimin Zhang and Congsen Wang and Andrew C.-H. Sue}, doi = {10.1002/anie.202509177}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509177}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral self-sorting of flexible covalent organic pillars for adaptive molecular recognition}, volume = {64}, year = {2025}, }
• (2025). Tailoring tubular supramolecular polymers with polar lumens to host hydrophilic dye molecules. ANGEW, 64(36), e202509156. (www)

  @article{ , abstract = {Supramolecular polymers are living an intense research period in which new synthetic strategies, unusual morphologies, and diverse promising applications are being explored. We contribute here to this field with the development of a unique class of supramolecular polymers that are able to selectively encapsulate guest molecules within their lumen. This is achieved through a rational design of the monomer units, which self-assemble in amphiphilic cyclic entities that then stack into lipophilic tubular architectures that contain a polar pore. These tailored assemblies are able to host hydrophilic dye molecules that are complementary in size and chemical affinity for the pore coating. Dye extraction is characterized by: (1) the emergence of the dye absorption and emission features in solution, (2) a red shift of the absorption and emission maxima, caused by a confined environment of high viscosity, and (3) an energy transfer process from the monomer at the tube's walls to the included dye guest, which was characterized by photoluminescence (PL), excitation, and transient absorption measurements. When different dyes are co-encapsulated, the tubular supramolecular polymer provides a unidimensional confined chiral environment to promote sequential energy transfer processes between them.}, archive = {J_ANGEW}, author = {Irene Sancho-Casado and Fátima Aparicio and Marina González-Sánchez and Raquel Chamorro and Víctor Vega-Mayoral and Juan Cabanillas-González and David González-Rodríguez}, doi = {10.1002/anie.202509156}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509156}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring tubular supramolecular polymers with polar lumens to host hydrophilic dye molecules}, volume = {64}, year = {2025}, }
• (2025). Alkali metal cations impact the selectivity of radical-mediated electrochemical C─H chlorination. ANGEW, 64(36), e202509115. (www)

  @article{ , abstract = {Electrochemistry offers a promising route toward facilitating organic transformation reactions in a sustainable manner. However, there are often a multitude of factors at play; hence, it can be unclear how operating conditions can be rationally tuned to optimize selectivity. Here, we demonstrate how the identity of alkali metal cations in the electrolyte can control the selectivity of electrochemical C─H chlorination. Specifically, we obtained a 90.3% Faradaic efficiency with KCl as compared to 78.4% with LiCl for the conversion of cyclohexane to chlorocyclohexane at 1000 mA using an IrO x electrode. Electron paramagnetic resonance spectroscopy experiments indicate a greater propensity for Cl − oxidation to generate Cl radicals in the order: K + > Na + > Li + . This leads to an increase in the selectivity toward the chlorination of cyclohexane and a concomitant decrease in competitive Cl 2 formation. Density functional theory calculations and in situ Raman spectroscopy experiments indicate that this is likely due to a decrease in *Cl binding energy on IrO x in the presence of K + . These findings highlight the important role of alkali metal cations, which can be a key consideration for designing electrochemical organic synthesis systems.}, archive = {J_ANGEW}, author = {Bo Wu and Ruihu Lu and Tenghui Yuan and Beijing Cai and Bingqing Wang and Bote Zhao and Shibo Xi and Ziyun Wang and Yanwei Lum}, doi = {10.1002/anie.202509115}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509115}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alkali metal cations impact the selectivity of radical-mediated electrochemical C─H chlorination}, volume = {64}, year = {2025}, }
• (2025). A genetically encoded homocysteine precursor to probe protein active sites and to addict escherichia coli to a noncanonical amino acid directly involved in catalysis. ANGEW, 64(36), e202509112. (www)

  @article{ , abstract = {Noncanonical amino acids (ncAAs) incorporated into proteins by stop codon suppression are powerful tools to probe and expand protein structure and function. Although homocysteine (Hcy) is a ubiquitous, naturally occurring amino acid, it was excluded from the universal genetic code. Hcy is very interesting, yet mostly unexplored, for probing protein active sites because of its subtle structural and electronic differences from cysteine and serine, which are widespread catalytic residues in enzymes. We report the genetic encoding of a new protected Hcy precursor, HcyX, that can be conveniently deprotected by chemical reductants or bioorthogonal reagents. We find varying and sometimes remarkable levels of activity for different purified enzymes with Hcy at catalytic positions. By exploiting partial intracellular deprotection to Hcy, we show that two proteins rendered Hcy-dependent, an intein and thymidylate synthase, can rescue growth of Escherichia coli by catalyzing a reaction essential for cell survival. To the best of our knowledge, these are the first examples in which cell growth is linked to a genetically incorporated ncAA directly involved in catalysis. We further demonstrate that Hcy-based disulfide bonds are chemically more stable than cysteine disulfides. Together, these findings open new paths for the experimental evolution of the genetic code.}, archive = {J_ANGEW}, author = {Clara Dunker and Henning D. Mootz}, doi = {10.1002/anie.202509112}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A genetically encoded homocysteine precursor to probe protein active sites and to addict escherichia coli to a noncanonical amino acid directly involved in catalysis}, volume = {64}, year = {2025}, }
• (2025). Enzyme-assisted confined synthesis of metal nanoparticles in covalent organic frameworks for efficient enzyme-metal cascade catalysis. ANGEW, 64(36), e202509105. (www)

  @article{ , abstract = {The integration of enzymatic and metal catalysis in cascade reactions offers a highly efficient approach for producing high-value chemicals, such as chiral pharmaceuticals. However, overcoming the inherent incompatibility between metal and enzyme catalysts and optimizing their stability and activity to achieve effective synergy, remains a significant challenge. Here, we present an enzyme-assisted, confined synthesis of metal nanoparticles (MNPs) within the nanochannels of covalent organic frameworks (COFs), to construct efficient enzyme-metal hybrid catalysts for cascade reactions. The COF nanochannels stabilize the enzyme during MNP formation and the catalytic process, and synergize with the enzyme to regulate the size, dispersion, and electronic state of the MNPs through surface amino acid residues, realizing the co-encapsulation and dual-optimization of both components. Using Candida antarctica lipase B (CALB) and Pd nanoparticles as a model system, Pd/CALB@COF exhibits an 8.2-fold higher yield in the kinetic resolution (KR) of racemic 1-phenylethylamine (1-PEA), and a 2.7-fold enhancement in racemization conversion, compared to counterparts without COF. Their synergy in dynamic kinetic resolution (DKR) delivers 91% yield, >98% enantiomeric excess (e.e.) value, and recyclability, with applicability to various chiral amines. This strategy has been validated across different metal-enzyme systems, establishing a versatile platform for designing efficient enzyme-metal cascade systems.}, archive = {J_ANGEW}, author = {Qin Wang and Chunyan Xing and Mengchu Feng and Yuying Yang and Dianshen Pang and Xiao Feng and Yuanyuan Zhang and Bo Wang}, doi = {10.1002/anie.202509105}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509105}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzyme-assisted confined synthesis of metal nanoparticles in covalent organic frameworks for efficient enzyme-metal cascade catalysis}, volume = {64}, year = {2025}, }
• (2025). Synergy of oxygen vacancies and ni single atoms toward efficient urea photosynthesis from CO2 and n2. ANGEW, 64(36), e202509048. (www)

  @article{ , abstract = {The direct photochemical synthesis of urea under mild conditions presents considerable promise. Nevertheless, the photocatalytic urea synthesis is severely restricted by the co-adsorption and activation of inert CO 2 and N 2 molecules. Herein, an ingenious design of a high-performance Ni 1 /TiO 2- X catalyst by strategically coupling Ni single atoms (Ni SAs) and oxygen vacancies (Ov) onto urchin-like TiO 2 architecture. By virtue of the unique synergistic catalysis between atomically dispersed Ni species and precisely engineered Ov sites, the Ni 1 /TiO 2- X catalyst achieves a remarkable urea production rate of 15.73 µmol g cat. −1 h −1 . Further mechanistic studies reveal that the atomically dispersed Ni sites facilitate N 2 adsorption and activation, generating *N 2 species, while the adjacent Ov sites activate CO 2 to form *CO intermediates. More intriguingly, the *CO species can migrate from the Ov site to the nearby Ni active centers, where they spontaneously undergo thermodynamic coupling with *N 2 to form a “tower-like” urea precursor (*NCON* intermediate), subsequently converting to urea. The present work establishes a dual-active-site mechanism, comprising isolated Ni centers and adjacent Ov sites, which synergistically lowers the activation barrier for urea photosynthesis and accelerates reaction kinetics, and pioneers a transition strategy for the environmentally friendly and efficient synthesis of high-value products.}, archive = {J_ANGEW}, author = {Bo Ding and Tianren Liu and Wensheng Zhang and Zhishan Liang and Youlin Huang and Dongdong Qin and Yingying Fan and Dongxue Han}, doi = {10.1002/anie.202509048}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202509048}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergy of oxygen vacancies and ni single atoms toward efficient urea photosynthesis from CO2 and n2}, volume = {64}, year = {2025}, }
• (2025). Transfer learning-assisted SERS: Predicting molecular identity and concentration in mixtures using pure compound spectra. ANGEW, 64(36), e202508717. (www)

  @article{ , abstract = {Identifying and quantifying compounds in unknown mixtures represents the ultimate goal of surface-enhanced Raman scattering (SERS) spectroscopy but remains a significant challenge in real-world applications. Existing machine learning-driven SERS methods are limited by their reliance on prior knowledge of mixture composition, while time-consuming experimental testing of all possibilities is not feasible. We integrate the molecular specificity of SERS with an adaptive transfer learning (TL) strategy to sequentially identify and quantify carnitine components in 11 unknown binary, ternary, and quaternary multicarnitine mixtures, achieving 100% identification accuracy and a mean quantitation error of only 3%. All models are trained solely on pure compound spectral data, enabling scalable, qualitative, and quantitative analysis of complex, unseen multiplex spectra—without requiring costly and time-consuming training data collection for every possible mixture. This predictive transfer learning-driven approach marks a transformative leap for practical SERS applications, allowing accurate analysis of complex mixtures without prior knowledge of components or ratios.}, archive = {J_ANGEW}, author = {Emily Xi Tan and Jaslyn Ru Ting Chen and Desmond Wei Cheng Pang and Nguan Soon Tan and In Yee Phang and Xing Yi Ling}, doi = {10.1002/anie.202508717}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202508717}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transfer learning-assisted SERS: Predicting molecular identity and concentration in mixtures using pure compound spectra}, volume = {64}, year = {2025}, }
• (2025). Sub-1 nm CuO-phosphomolybdic acid nanosheets for ultrasound-controlled pyroptosis activation and tumor immunotherapy. ANGEW, 64(36), e202508544. (www)

  @article{ , abstract = {Inducing pyroptosis effectively transforms immunosuppressive “cold tumors” into immunogenic “hot tumors” to enhance tumor immunotherapy. However, uncontrolled pyroptosis activation risks systemic inflammation and tumor metastasis. In this study, we used a solvothermal method to synthesize a sub-1 nm copper oxide-phosphomolybdic acid nanosheet (CuO-PMA) for ultrasound (US)-controlled reactive oxygen species (ROS) generation to induce pyroptosis. Owing to the narrow bandgap of CuO-PMA, the electron holes are rapidly separated under US irradiation, then quickly migrate through the sub-nanosheet structure to the surface to catalyze the formation of singlet oxygen (¹O₂) and superoxide anions (•O₂⁻), while simultaneously consuming glutathione (GSH). Furthermore, leveraging electron delocalization properties, US triggered the directional migration of electrons in CuO-PMA, facilitating the Cu(II)-to-Cu(I) transition to enhance hydroxyl radical (•OH) production. The ROS burst together with ions and h + -mediated GSH exhaustion synergistically provokes mitochondrial oxidative stress, activating the caspase-1/GSDMD axis to induce pyroptosis. In vivo experiments demonstrated that CuO-PMA significantly inhibited tumor growth and showed excellent antitumor immunotherapeutic effects. This sub-nanosheet amplifies ROS generation in response to the electronic delocalization characteristics of the US, which provides a new strategy for the ultrasound-controlled pyroptosis activation (sonopyroptosis) and tumor immunotherapy.}, archive = {J_ANGEW}, author = {Junhao Shao and Binbin Ding and Hao Chen and Zhendong Liu and Sainan Liu and Xinyu Ma and Jiwei Wang and Zhanfeng Wang and Jiashi Zhang and Kuo He and Yarui Hu and Ping'an Ma and Jun Lin}, doi = {10.1002/anie.202508544}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202508544}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sub-1 nm CuO-phosphomolybdic acid nanosheets for ultrasound-controlled pyroptosis activation and tumor immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Chemical proteomics identifies RBBP7 as a new e3 ligase supporting targeted protein degradation. ANGEW, 64(36), e202508538. (www)

  @article{ , abstract = {Targeted protein degradation (TPD) has been recognized as a powerful therapeutic strategy for the treatment of a wide range of diseases. However, the application of existing degraders is constrained by their dependence on a limited number of E3 ubiquitin ligases, such as CRBN and VHL. To address this limitation, we developed a suite of novel small-molecule degraders by integrating an ynamide electrophile into protein-targeting ligands. These compounds demonstrated remarkable target degradation capability. Subsequent proteome profiling and functional validation revealed that Cys97 residue of retinoblastoma binding protein 7 (RBBP7) E3 ligase was covalently engaged and responsible for the degradation mechanism. Furthermore, the ynamide motif has proved to be a versatile and transplantable chemical handle, facilitating the development of degraders targeting a wide range of proteins, including CDK4, PDE5, PI3K, AKT, BCR-ABL, BRD4, EGFR L858R , and EGFR L858R/T790M/C797S . Notably, incorporation of ynamide into the “pan-kinase” inhibitor XO44 yielded degraders capable of simultaneously degrading various kinases, such as PI3K, Syk, AKT, and GSK-3β, further highlighting the general feasibility of this approach. Importantly, the ynamide-containing degraders demonstrated significantly enhanced anticancer potency compared to their parent inhibitors.}, archive = {J_ANGEW}, author = {Yue Liu and Tao Yang and Lei Huang and Shengrong Li and Tongzheng Liu and Yi Tan and Zhengqiu Li}, doi = {10.1002/anie.202508538}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202508538}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical proteomics identifies RBBP7 as a new e3 ligase supporting targeted protein degradation}, volume = {64}, year = {2025}, }
• (2025). Engineering the microporous environment of flexible Metal–Organic frameworks with bifunctionality for promoting the separation of ethylene from a ternary mixture. ANGEW, 64(36), e202508419. (www)

  @article{ , abstract = {The separation of ethylene (C 2 H 4 ) from mixtures with carbon dioxide (CO 2 ) and acetylene (C 2 H 2 ) is of great industrial importance but remains a critical challenge. Here, we report that a rationally designed flexible metal–organic framework (FMOF), featuring a specifically engineered microporous environment with bifunctionality, can promote the efficient one-step separation of C 2 H 4 from a ternary mixture. Adsorption isotherms and dynamic breakthrough tests provide experimental evidence confirming the selective adsorption of CO 2 and C 2 H 2 over C 2 H 4 on such a FMOF, as well as its ability to separate C 2 H 4 from a CO 2 /C 2 H 2 /C 2 H 4 ternary mixture. Theoretical calculations and simulations provide critical insights into the flexible adsorption process and the separation mechanism of the FMOF. The bifunctionality incorporated in FMOF provides exceptionally strong binding of CO 2 and C 2 H 2 but inhibition of C 2 H 4 , which, in turn, enables high adsorption selectivity for CO 2 /C 2 H 4 and C 2 H 2 /C 2 H 4 . This FMOF has high potential for industrial applications in the separation of C 2 H 4 from gas mixtures.}, archive = {J_ANGEW}, author = {Kang Wang and Yao Jiang and Hui Zhang and Shaojun Jia and Qi Wang and Peng Cui and Thamraa AlShahrani and Shengqian Ma}, doi = {10.1002/anie.202508419}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202508419}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering the microporous environment of flexible Metal–Organic frameworks with bifunctionality for promoting the separation of ethylene from a ternary mixture}, volume = {64}, year = {2025}, }
• (2025). Synthesis and reactivity of a mono-coordinated triplet bismuthinidene. ANGEW, 64(36), e202508250. (www)

  @article{ , abstract = {The triplet bismuthinidene Ar*Bi ( 4 ) stabilized by a very bulky septiphenyl ligand (Ar* = 3,5- i -Pr 2 -2,6-(2,6-Me 2 -3,5-(2,6- i -Pr 2 C 6 H 3 ) 2 –C 6 H)–C 6 H) was synthesized by dehydrogenation of in situ formed bismuth dihydride Ar*BiH 2 ( 3 ). Oxidative addition reactions of 4 with alkyl halides (MeI, EtBr, i -PrBr) yielded bismuthanes Ar*Bi(Me)I ( 5 ), Ar*Bi(Et)Br ( 6 ), and Ar*Bi( i -Pr)Br ( 7 ), which reacted with LiAlH 4 and LiAlD 4 to the thermally robust bismuth monohydrides Ar*Bi(R)H (R = Me 8 , Et 10 , i -Pr 12 ) and monodeuterides Ar*Bi(R)D (R = Me 9 , Et 11 , i -Pr 13 ). Ar*Bi(NMe 2 ) 2 1 and Ar*BiH 2 3 were characterized in situ by 1 H NMR spectroscopy and sc-XRD ( 1 ), whereas the other compounds were characterized by heteronuclear NMR ( 1 H/ 2 H (D), 13 C) and IR spectroscopy, elemental analysis ( Ar*-2 , Ar*-3 , Ar*-5 , Ar*-7 , Ar*I , Ar*H , 2 , 4 − 7 ), as well as by UV–vis ( 4 ) and sc-XRD ( Ar*-7 , Ar*I , Ar*Li·Li t -Bu , Ar*H , 1 , 2 , 4 , 12 ). Quantum chemical calculations revealed the triplet character of the bismuthinidine 4 .}, archive = {J_ANGEW}, author = {Yannick Schulte and Timo Freese and Christoph Wölper and Jan Schulte and Gebhard Haberhauer and Stephan Schulz}, doi = {10.1002/anie.202508250}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202508250}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and reactivity of a mono-coordinated triplet bismuthinidene}, volume = {64}, year = {2025}, }
• (2025). On-demand photodegradable and thermo-reversible, soft, transparent dithioacetal hydrogels. ANGEW, 64(36), e202508160. (www)

  @article{ , abstract = {Stimuli–reversible, chemically cross-linked polymers capable of altering their physicochemical and mechanical properties on demand, upon application of external stimuli (e.g., light, temperature), are highly desirable for the development of multifunctional materials. Herein, we report a facile chemical platform for the synthesis of photodegradable and thermo-reversible, model hydrogels consisting of poly(ethylene glycol) (PEG) as the elastic strands and dithioacetal moieties at the cross-link points. The gels were synthesized via an acid-catalyzed step-growth reaction of a difunctional PEG-thiol macromer with a wisely selected aromatic dialdehyde cross-linker. The formation of the photosensitive dithioacetal bonds at the cross−links rendered the hydrogels photodegradable, whereas the production of the initial comonomers as the main photoproducts after irradiation endowed the material with thermoreversible properties. The linear viscoelastic behavior of water-swollen gels, their photodegradation under UV ( λ = 254 nm) irradiation at very low intensity (0.063 mW cm −1 ), and the reversible reformation of the hydrogel upon heating were investigated by dynamic shear rheology. Mechanistic insights for the photodegradation mechanism of the system were gained by 1 H NMR spectroscopy and kinetic studies on a model dithioacetal compound.}, archive = {J_ANGEW}, author = {Maria Psarrou and Ioanna Chatzaki and Antonis Mavromanolakis and Theodore Manouras and Dimitris Vlassopoulos and Maria Vamvakaki}, doi = {10.1002/anie.202508160}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202508160}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-demand photodegradable and thermo-reversible, soft, transparent dithioacetal hydrogels}, volume = {64}, year = {2025}, }
• (2025). Doping bulky fluorinated organic anion to construct highly efficient anion-π+ type photosensitizers for cancer phototheranostics. ANGEW, 64(36), e202507949. (www)

  @article{ , abstract = {Anion-π + type photosensitizers with aggregation-induced emission (AIE) feature have demonstrated promising potential in photodynamic therapy (PDT) against cancer. However, previous reports mainly focused on modifying the π + core but often overlooked the crucial role of anions. Herein, we present a facile strategy to modulate the fluorescence intensity and cellular uptake of anion-π + type AIE photosensitizers by doping bulky fluorinated organic anions into nanoparticles (NPs). Anion-π + type AIE photosensitizer DPBCF-Br with different ratios of bulky anions (TB or FTB) were encapsulated into DSPE-PEG 2000 to obtain NPs (named DF-TB X or DF-FTB X , X denotes the molar ratios of TB or FTB to DPBCF-Br). Expectedly, as the doping molar ratios increased, a progressive enhancement in fluorescence intensity of the obtained NPs was observed. This can be ascribed to the steric effect of bulky organic anions and the formation of a hydrophobic environment within the NPs. Interestingly, the optimal cellular uptake was achieved at X = 8 in DF-TB 8 and DF-FTB 8 , resulting from the balance between lipophilicity and electronegativity. Ultimately, DF-FTB 8 demonstrated outstanding cellular imaging capabilities and high intracellular reactive oxygen species generation, achieving efficient cancer phototheranostics. This facile bulky anion doping strategy will pave a new way for the construction of robust anion-π + type photosensitizers.}, archive = {J_ANGEW}, author = {Lingxiu Liu and Jianye Gong and Xue Wang and Guoyu Jiang and Ben Zhong Tang and Jianguo Wang}, doi = {10.1002/anie.202507949}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Doping bulky fluorinated organic anion to construct highly efficient anion-π+ type photosensitizers for cancer phototheranostics}, volume = {64}, year = {2025}, }
• (2025). Near-infrared emissive molecular carbons based on quadruple [n]Helicenes. ANGEW, 64(36), e202507891. (www)

  @article{ , abstract = {We present a molecular design strategy that combines structural multiplicity and π-extension on a quaterrylene diimide scaffold to construct efficient near-infrared (NIR) circularly polarized luminescence (CPL) emitters. Through a carefully controlled synthesis involving sequential regioselective Suzuki coupling followed by Sholl-type oxidative cyclization, we successfully obtained two novel quadruple [n]helicenes ( QnH ). Comprehensive experimental characterization and theoretical calculations demonstrated their distinct configurational preferences: Q5H exclusively adopted the meso ( P , P , M , M ) configuration, while Q6H produced only the ( P , P , P , P )/( M , M , M , M ) enantiomeric pair. Single-crystal X-ray diffraction unambiguously confirmed the unique “four-bladed propeller” structure of ( P , P , M , M )- Q5H . Both compounds demonstrated intense NIR fluorescence emission with photoluminescence quantum yields ( Φ PL ) of 47% for Q5H and 37% for Q6H . The chiral ( P , P , P , P )/( M , M , M , M )- Q6H enantiomers showed exceptional chiroptical properties, including intense Cotton effects reached 719 M −1 cm −1 at 410 nm, a high absorption dissymmetry factor | g abs | of 0.035, and prominent CPL activity across 600–800 nm with a CPL brightness ( B CPL ) of 93 M −1 cm −1 .}, archive = {J_ANGEW}, author = {Yilun Zhao and Zixin Liu and Xu Wen and Kai Chen and Guogang Liu and Zhaohui Wang and Wei Jiang}, doi = {10.1002/anie.202507891}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507891}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared emissive molecular carbons based on quadruple [n]Helicenes}, volume = {64}, year = {2025}, }
• (2025). Mathematical double-matrix switchable homochiral ferroelectric. ANGEW, 64(36), e202507554. (www)

  @article{ , abstract = {Homochiral ferroelectrics have attracted increasing attention in recent years because of their distinctive chiroptical effects in contrast to ordinary ferroelectrics. Moreover, they provide a great opportunity to show mathematically switchable matrix elements between nonzero and zero values in both second-order nonlinear optical susceptibility χ (2) and piezoelectric d matrices to realize the dual on/off switching of second-harmonic generation circular dichroism (SHG-CD) and piezoelectric responses, which, however, has never been reported. Herein, for the first time, we reported homochiral metal halide ferroelectrics ( R -/ S -BTA) 2 CdBr 4 (BTA = 3-bromo-2-hydroxypropyltrimethylammonium), which exhibits a 432 F 2 ferroelectric phase transition at 362 K, accompanied by the switchable matrix elements between nonzero (for point group 2) and zero (for point group 432) values in both χ (2) and d matrices. They show strong SHG-CD effects with an anisotropy factor up to 1.28, far exceeding that of other chiral ferroelectrics. Notably, the 432 F 2 phase transition enables ( R -/ S -BTA) 2 CdBr 4 to show the unprecedented dual on/off switching of SHG-CD and piezoelectric response between the SHG-CD/piezoelectric active state in the ferroelectric phase and SHG-CD/piezoelectric inactive state in the paraelectric phase. Our findings shed light on the exploration of mathematical double-matrix switchable chiral ferroelectrics with SHG-CD and piezoelectric response switching.}, archive = {J_ANGEW}, author = {Xian-Jiang Song and Yan Qin and Yong Ai and Xiao-Gang Chen and Yan-Ran Weng and Hang Peng and Hui-Peng Lv and Ren-Gen Xiong and Wei-Qiang Liao}, doi = {10.1002/anie.202507554}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507554}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mathematical double-matrix switchable homochiral ferroelectric}, volume = {64}, year = {2025}, }
• (2025). Selective chemo-divergent hydrogenation of ethylene carbonate enabled by multi-functional Poly(Ionic liquids)-stabilized ru nanoparticles. ANGEW, 64(36), e202507548. (www)

  @article{ , abstract = {Cyclic carbonates, in particular ethylene carbonate (EC), are pivotal compounds across chemical sciences because of their unique properties. Although, their transformation into valuable products has attracted great attention, efficient and selective transformations remain challenging. In this work, we report a catalytic system composed of Ru nanoparticles (RuNPs) stabilized by poly(ionic liquids) (Ru@PIL), that enables the selective chemo-divergent hydrogenation of EC into either EtOH and CO 2 or EG and CH 4 , under solvent-free conditions. Those transformations relied on the multi-task ability of poly(ionic liquids) (PILs), which provides efficient electro-steric protection of the NPs, good solubility in neat carbonates, and organocatalytic activity depending on the nature of the PIL counter-anions. Hence, PIL incorporating nucleophilic anions, such as I − , triggers the cascade transformation of EC into EtOH via a sequential decarboxylation-hydrogenation process. Conversely, in the presence of non-nucleophilic anions, the PIL is catalytically a spectator, yielding to the “direct hydrogenation” of EC by the RuNPs.}, archive = {J_ANGEW}, author = {Wenjuan Wang and Thierry Tassaing and Joan Vignolle}, doi = {10.1002/anie.202507548}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507548}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective chemo-divergent hydrogenation of ethylene carbonate enabled by multi-functional Poly(Ionic liquids)-stabilized ru nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Bottom-up regulation of perovskite growth and energetics via oligoether functionalized self-assembling molecules for high-performance solar cells. ANGEW, 64(36), e202507513. (www)

  @article{ , abstract = {Self-assembling molecules (SAMs) are widely used as interfacial layers to optimize the surface properties of nickel oxides (NiO x ) in inverted perovskite solar cells (PSCs). However, less attention is paid to the effect of SAMs on the regulation of perovskite growth and energetics. Here, based on the donor-acceptor molecular backbone, an oligoether chain is introduced with different chain lengths to endow two novel SAMs, namely, EPA and MEPA, with good capability of bottom-up regulation of perovskite formation and energetics. Compared to the model SAM MPA, EPA and MEPA can render NiO x with better coverage and conductivity. Moreover, the oligoether chain-containing SAMs are able to assist the formation of perovskite film with ordered growth, high crystallization, and importantly well-matched energy level alignment at the top surface, especially for MEPA. Consequently, a remarkably high efficiency of 25.50% is realized for NiO x /MEPA-based PSCs along with good device stability, which can maintain 90% of the initial efficiency under ISOS-L-1 conditions over 1260 h.}, archive = {J_ANGEW}, author = {Xiaozhen Huang and Taiyu Wang and Wenjie Chen and Zhengye Wang and Zhiye Lin and Di Wang and Xiaofeng Li and Diwei Zhang and Shidong Cai and Xiafeng He and Jie Gao and Dong Wei and Hongfang Du and Youchao Wei and Yue Wang and Mingwei An and Yang Wang}, doi = {10.1002/anie.202507513}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507513}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bottom-up regulation of perovskite growth and energetics via oligoether functionalized self-assembling molecules for high-performance solar cells}, volume = {64}, year = {2025}, }
• (2025). Plasmon-ferroelectric induced multifield coupling effect accelerates charge spatial separation for boosting tandem photoredox catalysis. ANGEW, 64(36), e202507396. (www)

  @article{ , abstract = {Integrating solar-driven CO 2 reduction with organic oxidation is regarded as an ideal strategy for achieving carbon neutrality. However, further enhancement of photocatalytic efficiency is persistently blocked by low photogenerated carrier yields and unavoidable fast bulk electron/hole recombination. Herein, we propose to design a plasmonic-ferroelectric heterojunction (WO 3-x /K 4 Nb 6 O 17 ), which enhances localized electromagnetic field and ferroelectric polarization field simultaneously through the cooperative coupling of localized surface plasmon resonance (LSPR) effect in WO 3-x and ferroelectric polarization in K 4 Nb 6 O 17 , thereby not only promoting energetic hot-carriers generation, but also accelerating bulk charge separation. Ultimately, hot-electrons and photoelectrons are directionally transferred and extracted to K 4 Nb 6 O 17 surface for CO 2 reduction, whereas massive holes are accumulated in WO 3-x for benzylicalcohol activation. Under mild conditions, WO 3-x /K 4 Nb 6 O 17 exhibits superior CO yield (294.76 µmol g −1 h −1 ), which is 9.87 and 6.27-folds higher than that of K 4 Nb 6 O 17 and WO 3-x , respectively. Meanwhile, compared to the simple dehydrogenation of benzylicalcohol to benzaldehyde in K 4 Nb 6 O 17 and WO 3-x , WO 3-x /K 4 Nb 6 O 17 prefers to trigger benzylicalcohol C─C coupling for directed production of more value-added hydrobenzoin (313.15 µmol g −1 h −1 ). This work would open a conceptual vista for designing multifield coupling structures to facilitate charge spatial separation and directional transfer, which would inspire further establishment of efficient novel photocatalysts and solar-to-fuel conversion systems to meet the green and sustainable development goals.}, archive = {J_ANGEW}, author = {Jingjing Yang and Ziang Chen and Zongying Wang and Qizhu Qian and Bicai Pan and Qun Zhang and Chong Xiao and Yi Xie}, doi = {10.1002/anie.202507396}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507396}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plasmon-ferroelectric induced multifield coupling effect accelerates charge spatial separation for boosting tandem photoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Janus-type photophysics of rotational isomers in a diphenylanthracene dimer. ANGEW, 64(36), e202507385. (www)

  @article{ , abstract = {Organic molecular dimers serve as valuable model systems for manipulating and exploring interchromophore interactions. However, the structural flexibility introduced by linker or chromophore rotation gives rise to conformational isomers with distinct atomic arrangements, complicating the interpretation of photophysical processes. In this study, we investigate 9,9′,10,10′-tetraphenyl-2,2′-bianthracene ( TPBA ) to elucidate the distinct electronic characteristics of its two primary rotational isomers: syn - and anti -TPBA . To address the “Janus-type” photophysical behavior of these isomers, we employed a comprehensive suite of static and time-resolved spectroscopic techniques, including excitation-wavelength-dependent time-resolved photoluminescence, transient absorption, and time-resolved electron paramagnetic resonance, complemented by theoretical calculations. syn - and anti -TPBA exhibit markedly different emissive properties and charge-transfer characteristics, reflecting their unique exciton coupling behaviors. Additionally, they showcase distinct triplet formation rates and exhibit environment-dependent triplet formation mechanisms. This in-depth study of the Janus-like electronic properties of TPBA underscores the critical role of conformational isomerism in organic molecular dimers. Neglecting these structural variations can obscure the true photophysical landscape and lead to misinterpretations of mechanistic processes, highlighting the necessity of considering conformational heterogeneity in molecular design and photophysical studies.}, archive = {J_ANGEW}, author = {Byeongjoo Kang and Daniel Yim and Jaewook Kim and Hyeonwoo Choi and Kyeong Mo Lim and Juwon Oh and Naitik A. Panjwani and Hyungjun Kim and Woojae Kim}, doi = {10.1002/anie.202507385}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507385}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Janus-type photophysics of rotational isomers in a diphenylanthracene dimer}, volume = {64}, year = {2025}, }
• (2025). Photoresponsive slide-ring gels enable modulation of sliding dynamics. ANGEW, 64(36), e202507073. (www)

  @article{ , abstract = {Cyclodextrin-based slide-ring gels (SRGs) have emerged as a promising class of materials owing to their unique topology. Upon mechanical loading, the slidable cross-links of the polymer network freely translocate along the polymer backbone enabling pronounced energy dissipation in the material, which is associated with exceptional ductility and toughness. Despite the critical role of sliding dynamics in defining SRG mechanical properties, attempts to control them have primarily been limited to tuning the overall loading of macrocycles. Further, SRGs that can be triggered via an external stimulus have yet to be reported. In this work, we present light-responsive SRGs based on azobenzene-containing polymers. Reversible photoswitching of the azobenzenes modulates the sliding dynamics of the threaded α-cyclodextrin (α-CD) macrocycles. By using UV–Vis and circular dichroism spectroscopy, we show that α-CDs readily bind to the azobenzenes along the polymer backbone in the E configuration. Upon light irradiation, and thus isomerization to the Z isomer, the macrocycles no longer interact with the azobenzenes, allowing them to freely translocate along the polymer backbone. As a result of this E to Z isomerization and difference in sliding dynamics, the mechanical properties of the SRGs reversibly alternate between a stiff and a soft state.}, archive = {J_ANGEW}, author = {Dalila Cafagno and Serena Silvi and Mark W. Tibbitt and Stefan Mommer}, doi = {10.1002/anie.202507073}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoresponsive slide-ring gels enable modulation of sliding dynamics}, volume = {64}, year = {2025}, }
• (2025). Expanding the inositol pyrophosphate toolbox: Stereoselective synthesis and application of PP-InsP4 isomers in plant signaling. ANGEW, 64(36), e202507058. (www)

  @article{ , abstract = {Inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despite extensive research on well-characterized exhaustively phosphorylated PP-InsPs, such as 5-PP-InsP 5 (5-InsP 7 ) and 1,5-(PP) 2 -InsP 4 (1,5-InsP 8 ), the functional relevance of less abundant not fully phosphorylated isomers, remains largely unknown. In this study, we synthesized all unsymmetric 5-PP-InsP 4 isomers in enantiopure form and assigned their structures using 31 P-NMR analysis in combination with a chiral solvating agent. Additionally, we developed 18 O-labeled PP-InsP 4 standards for mass spectrometry in combination with capillary electrophoresis (CE-MS), enabling the assignment of PP-InsP 4 in Arabidopsis thaliana under phosphate starvation. Our findings show that the previously detected, phosphate starvation-induced root-specific PP-InsP 4 isomer does not match any 5-PP-InsP 4 isomer, contrary to previous suggestions, thus indicating an alternative phosphorylation pattern. Enzyme assays further demonstrate that Arabidopsis ITPK1 selectively phosphorylates [6-OH]-InsP 5 and [3-OH]-InsP 5 at the 5-position, while other InsP 5 isomers remain unchanged. This suggests that an unidentified enzymatic activity is involved in the formation of the elusive root PP-InsP 4 species. Our study provides a comprehensive framework for the synthesis, analysis, and functional investigation of PP-InsP 4 , providing an entry point for future studies on their biochemical activity and their physiological roles.}, archive = {J_ANGEW}, author = {Kevin Ritter and Anne-Sophie C. Braun and Guizhen Liu and Mengsi Lu and Verena Gaugler and Gabriel Schaaf and Henning Jacob Jessen}, doi = {10.1002/anie.202507058}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202507058}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expanding the inositol pyrophosphate toolbox: Stereoselective synthesis and application of PP-InsP4 isomers in plant signaling}, volume = {64}, year = {2025}, }
• (2025). Engineered nanofluidics for molecular recognition and physical perception. ANGEW, 64(36), e202506689. (www)

  @article{ , abstract = {Nanofluidics has garnered significant attention as the ultra-sensitive method for molecular recognition and physical perception that are not easily accessible through the traditional methods. The development of nanofluidic devices necessitates the integrated solid-state nanochannels/nanopores with versatile surface modification strategies using precise nanofabrication techniques. This review systematically summarizes the development of the solid-state nanochannels and nanopores, nanofabrication methods, sensing principles, transport characteristics, and the strategies employed to perceive molecules and physical stimuli. The discussion also emphasizes promising research directions and explores how the interaction between interface chemistry influenced by molecular recognition and physical stimuli, in conjunction with the exceptional ion transport properties of nanofluidic devices, significantly impacts the sensing performance of the nanofluidics. Lastly, we present the vision for the future prospects of biomimetic nanofluidic devices in ionic sensing applications.}, archive = {J_ANGEW}, author = {Congcong Zhu and Yuge Wu and Xin Li and Xiuling Li and Xinmiao Liang and Lei Jiang and Liping Wen}, doi = {10.1002/anie.202506689}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202506689}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered nanofluidics for molecular recognition and physical perception}, volume = {64}, year = {2025}, }
• (2025). Structural basis for a scaffolding role of the COM domain in nonribosomal peptide synthetases. ANGEW, 64(36), e202506621. (www)

  @article{ , abstract = {Nonribosomal peptide synthetases (NRPSs) are multi-domain enzymes that catalyze the biosynthesis of therapeutically relevant natural products. Efficient peptide synthesis relies on intricate domain interactions, whose underlying principles remain poorly understood. The communication-mediating (COM) domains facilitate interactions between separate NRPS subunits. For unknown reasons, COM domains co-occur with epimerization (E) domains, are partially embedded within the adjacent condensation (C) domains and can also be found as internal cis -COM domains. These features set COM domains apart from other docking domains. We present the first crystal structure of a cis -COM domain within an E-COM-C domain arrangement from modules 4 and 5 of bacitracin synthetase 3 (BacC). The structure reveals a compactly folded COM domain sandwiched between E and C domains, suggesting a role of the COM domain in orienting these domains for efficient peptidyl carrier protein (PCP) shuttling. Through mutational analyses, dipeptide formation assays, and proximity-dependent photo-crosslinking experiments, we investigated both cis - and trans -COM domains and provide evidence supporting a principal role of COM domains as scaffolds of NRPS architecture. Their function as docking domains may be a secondary consequence of their division into separate donor and acceptor parts.}, archive = {J_ANGEW}, author = {Julia Diecker and Benedikt Hermanns and Jennifer Rüschenbaum and René Rasche and Wolfgang Dörner and Alexander Schröder and Daniel Kümmel and Henning D. Mootz}, doi = {10.1002/anie.202506621}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202506621}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural basis for a scaffolding role of the COM domain in nonribosomal peptide synthetases}, volume = {64}, year = {2025}, }
• (2025). Calix[8]Arene-tethered dendritic octamer acceptor with ultrahigh molecular weight enables 20.7% efficiency organic solar cells with exceptional stability. ANGEW, 64(36), e202506445. (www)

  @article{ , abstract = {Increasing the molecular weight of the acceptor is an effective strategy to suppress excessive crystallization and molecular diffusion, thereby addressing morphological challenges in organic solar cells (OSCs). Therefore, designing high-molecular-weight acceptors with well-defined structures is crucial for achieving efficient and stable OSCs towards commercialization. Herein, we report a calix[8]arene-tethered dendritic octameric acceptor with a molecular weight of 14243 g mol −1 and a well-defined structure. Owing to its dendritic structure, which facilitates both multidimensional charge transport and molecular interactions, C8-IC can operate efficiently, achieving a high-power conversion efficiency (PCE) of 18.7%, despite its lower crystallinity. Moreover, it effectively acts as a crystallization manipulator, regulating the interaction and crystallization within the D18:L8-BO system. This optimizes charge management in the ternary system, achieving a state-of-the-art efficiency of 20.7%. To our knowledge, this is among the highest efficiency values reported for OSCs based on dendritic acceptors. Moreover, the ultrahigh molecular weight of the dendritic acceptor effectively increases the glass transition temperature ( T g ), inhibits molecular diffusion, and stabilizes the morphology, leading to significantly improved device stability. This work presents high-performance OSCs based on a dendritic acceptor with ultrahigh molecular weight and provides valuable insights into the design of acceptor materials for highly stable OSCs.}, archive = {J_ANGEW}, author = {Lunbi Wu and Tianchen Pan and Xinkang Wang and Yulong Hai and Sha Liu and Ruijie Ma and Junyu Lu and Liangbin Xiong and Yi Chan and Junyin Dong and Yao Li and Yongmin Luo and Lei Zhu and Biao Xiao and Jie Zhang and Junwu Chen and Tianyi Zhang and Jiaying Wu and Shengjian Liu and Tao Jia and Fei Huang}, doi = {10.1002/anie.202506445}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202506445}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Calix[8]Arene-tethered dendritic octamer acceptor with ultrahigh molecular weight enables 20.7% efficiency organic solar cells with exceptional stability}, volume = {64}, year = {2025}, }
• (2025). Antisolvent-bathing strategy with ultra-wide processing window for making high-efficiency perovskite solar cells in ambient air. ANGEW, 64(36), e202506418. (www)

  @article{ , abstract = {Most record-efficiency perovskite solar cells rely on spin-coating with antisolvent dripping, which is fundamentally incompatible with roll-to-roll (R2R) manufacturing. The crystallization kinetics of dynamic wet film during spin coating differs widely from the static wet film during R2R fabrication, which makes the existing crystallization control strategies become inapplicable while upscaling. The crystallization regulation of static wet film remains a critical challenge, particularly under ambient conditions. In this study, we employed the antisolvent-bathing method that can efficiently regulate the crystallization process of static wet films made by drop coating. Through systematic investigation of solvent-antisolvent interdiffusion kinetics and in-situ crystallization monitoring via time-resolved UV–Vis spectroscopy, we identify alkyl chlorides (particularly chloroform) as optimal bathing agents. The champion device made by CF bathing achieved an efficiency of 24.49% under ambient conditions (RH 30%–50%), representing the highest efficiency for perovskite solar cells made by the antisolvent bathing method. The device showed negligible decay after 2256 h storage in N 2 atmosphere. The method demonstrates exceptional environmental resilience to humidity and solvent accumulation, accompanied by an ultra-wide processing window (10 s–10 min bathing duration, >2 min post-bathing delay tolerance).}, archive = {J_ANGEW}, author = {Lixiu Zhang and Chuantian Zuo and Mei Zhang and Ruihao Chen and Xiangyu Chen and Ke Jin and Feng Hao and Keyou Yan and Zuo Xiao and Congcong Wu and Jingjing Chang and Yong Ding and Liming Ding}, doi = {10.1002/anie.202506418}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202506418}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antisolvent-bathing strategy with ultra-wide processing window for making high-efficiency perovskite solar cells in ambient air}, volume = {64}, year = {2025}, }
• (2025). Balancing tetrahedral and cation entropies for long-lifespan low-temperature zn-ion batteries. ANGEW, 64(36), e202506010. (www)

  @article{ , abstract = {Aqueous Zn-ion batteries (AZIBs) are promising candidates for next-generation energy storage. However, their application is hindered by Zn anode instability and reduced ionic conductivity at low temperatures. Here, we identified two decisive factors for low-temperature performance and anode stability of batteries: tetrahedral entropy and cation entropy. The former is closely related to antifreezing ability of electrolyte, while the latter is associated with the desolvation kinetics of Zn 2+ . We propose an effective strategy to balance the above two thermodynamic quantities by precisely tuning the molar fraction of the 1,3-butanediol (BDO) cosolvent with notable glass-forming ability. BDO enhances the tetrahedral entropy due to the disruption of the hydrogen-bond networks among water molecules, decreasing the solid–liquid transition temperature from −16.4 to −101 °C. Additionally, BDO modifies the solvated structure of Zn 2 ⁺ to limit the active water content, thus suppressing by-reactions at the electrode/electrolyte interface. The optimized electrolyte enables long-term cycling of Zn||Zn symmetric cells for over 4000 h at −40 °C under 0.1 mA cm −2 /0.1 mAh cm −2 , and renders PANI||Zn full cells capable of working across a broad temperature range (−40 °C to 60 °C). This work offers a guideline to design stable and low-temperature AZIBs, expanding the application scope for aqueous electrolytes.}, archive = {J_ANGEW}, author = {Yongtao Liu and Meijia Qiu and Yuxuan Liang and Jiahui Zhang and Jinguo Chen and Peng Sun and Wenjie Mai}, doi = {10.1002/anie.202506010}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202506010}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Balancing tetrahedral and cation entropies for long-lifespan low-temperature zn-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Regioselective hydration of terpenes with cofactor-independent carotenoid 1,2-hydratase. ANGEW, 64(36), e202505942. (www)

  @article{ , abstract = {Terminally hydrated terpenes are highly sought-after compounds in the flavor and fragrance industries. However, their selective synthesis remains a considerable challenge in catalysis. Regioselective hydration of non-activated C─C double bonds is typically hindered by poor selectivity and low atom efficiency in conventional methods. In this study, we harness the underexplored potential of the acyclic carotenoid 1,2-hydratase from Rubrivivax gelatinosus IL144, employing it as a whole-cell biocatalyst for cofactor-independent terminal hydration of a diverse range of terpenes. This enzyme demonstrates exceptional activity across more than 20 C 12 ─C 20 terpenes and shows notable tolerance to various functional groups, establishing it as a valuable tool for sustainable organic synthesis. We emphasize the critical influence of expression system choice in maximizing enzymatic performance, enabling high-yield transformations on the gram scale. Through a combination of homology modeling, consensus analysis, and targeted mutagenesis, essential residues involved in catalytic activity were identified. Notably, enhanced catalytic efficiency was only achievable through the epistatic effect of three specific mutations. These findings highlight the biocatalytic potential of acyclic carotenoid hydratase, offering a green and efficient route to the production of valuable tertiary alcohols.}, archive = {J_ANGEW}, author = {Philip Horz and Natalie Härterich and Andreas Schneider and Nicolas D. Travnicek and Bettina M. Nestl and Ursula Kahler and Bernhard Hauer}, doi = {10.1002/anie.202505942}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202505942}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioselective hydration of terpenes with cofactor-independent carotenoid 1,2-hydratase}, volume = {64}, year = {2025}, }
• (2025). Engineering PdAu/CeO2 Alloy/Oxide interfaces for selective methane-to-methanol conversion with water. ANGEW, 64(36), e202505716. (www)

  @article{ , abstract = {The direct conversion of methane-to-methanol remains a critical challenge in methane valorization. In this study, we unveil the crucial role of PdAu/CeO 2 catalysts in enabling selective methane transformation under mild conditions, using only water as the sole oxidant. Through a combination of experimental techniques, including XPS and catalytic testing, alongside density functional theory (DFT) calculations, we demonstrate that a Pd 0.3 Au 0.7 /CeO 2 catalyst, which predominantly exposes isolated Pd atoms, achieves remarkable methanol selectivity (∼80%) at 500 K with a 1:1 methane-to-water ratio. While Pd/CeO 2 efficiently activates methane, its tendency for overreaction leads to complete methanol decomposition, thereby limiting selectivity. Alloying Pd with Au on ceria mitigates this over-reactivity, preventing methanol degradation while maintaining sufficient catalytic activity. The PdAu/CeO 2 composite exhibits a synergistic effect: Pd in contact with the ceria support facilitates methane activation and water dissociation, while Au fine-tunes reactivity to promote methanol formation. DFT calculations confirm that isolated Pd sites at the PdAu/CeO 2 interface play a key role in balancing activity and selectivity. This work underscores the importance of alloy/oxide interfaces in controlling selective methane conversion with water and offers valuable insights for designing highly efficient catalysts for methanol synthesis.}, archive = {J_ANGEW}, author = {Estefanía Fernández-Villanueva and Pedro J. Ramírez and Pablo G. Lustemberg and Rubén Pérez and M. Verónica Ganduglia-Pirovano and José A. Rodriguez}, doi = {10.1002/anie.202505716}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202505716}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering PdAu/CeO2 Alloy/Oxide interfaces for selective methane-to-methanol conversion with water}, volume = {64}, year = {2025}, }
• (2025). Imaging-based high-content screening with clickable probes identifies XPB inhibitors. ANGEW, 64(36), e202505585. (www)

  @article{ , abstract = {High-content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS's ability to directly assess drug-protein interactions at endogenous levels, particularly in subcellular contexts. Here, we report an approach to address these limitations by combining confocal imaging-based HCS and bio-orthogonal labeling with clickable probes. As a proof-of-concept, we synthesized a probe Triptolide-alkyne (TL-alk) that rapidly and specifically labels xeroderma pigmentosum type B (XPB), a critical protein in nucleotide excision repair (NER). Probe-labeled XPB was conjugated to TAMRA to visualize the occupation of active sites, and EGFP and DAPI signals indicated XPB expression in the nucleus. Such a colorimetric HCS assay enabled the direct and precise measurement of drug occupancy rates in nuclear XPB of live cells. With this platform, pelitinib was identified as a novel ligand to bind XPB out of 1874 compounds containing. Food and Drug Administration (FDA)-approved drugs. Pelitinib formed a covalent bond with cysteine residue 342 of XPB, suppressed XPB's ATPase activity, impaired NER, and synergistically enhanced chemotherapy. This study not only overcomes limitations of HCS, but also demonstrates the transformative potential of bio-orthogonal labeling, such as in integration with HCS technologies, offering a novel framework for drug discovery targeting challenging protein systems.}, archive = {J_ANGEW}, author = {Shuqi Li and Hong-Rui Zhang and Yang Yang and Ben Chi-Bun Ko and Jin Shang and Haijun Guo and Dan Yang and Mankin Wong and Ricky Wing-Cheung Chan and Karen Ka-Yan Kung and Qian Zhao}, doi = {10.1002/anie.202505585}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202505585}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imaging-based high-content screening with clickable probes identifies XPB inhibitors}, volume = {64}, year = {2025}, }
• (2025). Integrating hydrophobic and hydrophilic building blocks for high-performance organic electrochemical transistors and biosensing. ANGEW, 64(36), e202505141. (www)

  @article{ , abstract = {Organic electrochemical transistors (OECTs) with mixed ionic‒electronic transport features have demonstrated significant potential in biosensing applications. Semiconductor polymers grafted with hydrophilic side chains have notably enhanced performance and applications. However, water-induced overswelling and doping in biocompatible aqueous environments hinder high-sensitivity detection. In this study, we introduce two block copolymers, DPP -b- Pg2T-T and NDI -b- Pg2T-T, which integrate both hydrophobic and hydrophilic segments to achieve balanced ionic–electronic conductivities and the sensing performance. These materials effectively suppress swelling and water doping, resulting in low noise signals in aqueous electrolytes. Consequently, devices based on two polymer materials exhibit superior ion concentration variation performance and enhanced sensing capabilities, with an improved sensitivity to dopamine (DA) of up to 266 mV dec −1 .}, archive = {J_ANGEW}, author = {Xingyu Jiang and Bin Li and Chuan Xiang and Cheng Shi and Mingzhou Yang and Dianjue Liu and Xinyu Dong and Jianhua Chen and Zi Wang and Jianyu Yuan and Lifeng Chi and Lizhen Huang}, doi = {10.1002/anie.202505141}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202505141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating hydrophobic and hydrophilic building blocks for high-performance organic electrochemical transistors and biosensing}, volume = {64}, year = {2025}, }
• (2025). Photocontrolled release of urea enables the detection of Urea–Urease intermediates by cryo-FTIR. ANGEW, 64(36), e202504332. (www)

  @article{ , abstract = {Caged compounds are a valuable tool to photocontrol the release of enzymatic substrates in a reaction. For example, caged urea molecules were proposed to control urea delivery to urease reactions and aid the determination of the catalytic mechanism of this enzyme. Owing to the success of several caged compounds based on ruthenium complexes, we synthesized a new inorganic caged urea (RuBpy-urea) and monitored the release of free urea by infrared spectroscopy upon irradiation. Transient infrared absorption (TRIR) indicates diffusion-controlled release of urea, and kinetics studies after photolysis demonstrate the functionality of the new caged molecule for photocontrolled delivery of urea to urease. Coupling photocontrolled delivery of urea to cryo-FTIR (fourier transform infrared spectroscopy) revealed that inhibition of urease results in different FTIR spectrum than the one observed for the noninhibited urease.}, archive = {J_ANGEW}, author = {Caterina G.C. Marques Netto and Sarah Bell and Caio B. Castro and Pedro Henrique Machado and Vatsal Purohit and Katherine M. Davis and Ana Paula L. Batista and R. Brian Dyer}, doi = {10.1002/anie.202504332}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202504332}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocontrolled release of urea enables the detection of Urea–Urease intermediates by cryo-FTIR}, volume = {64}, year = {2025}, }
• (2025). Synergistic self-assembled monolayers reinforce buried interface anchoring for high-efficiency tandem perovskite solar cells. ANGEW, 64(36), e202504237. (www)

  @article{ , abstract = {Carbazole-based self-assembled monolayers (SAMs) have been commonly used as a single-component hole transport layer (HTL) in inverted perovskite solar cells (PSCs), but suffer from facile π-π stacking and self-aggregations in solution and consequently poor anchoring ability with the atop perovskite layer. Herein, we developed a synergistic SAM (syn-SAM) strategy through blending a non-planar molecule 3,3-(4-amino-4H-1,2,4-triazole-3,5-diyl)-dibenzo acid (ABT) bearing multiple anchoring sites with the commonly used Me-4PACz SAM. The coexistence of these two components leverages π-π interactions and hydrogen bonding to mitigate aggregation effects, affording dense and uniform SAM, thereby enhancing anchoring at the perovskite buried interface and alleviating interfacial charge recombination. ABT incorporation further helps to mitigating tensile strain in perovskite film. Additionally, this strategy offers advantages of multi-device compatibility. The single-junction champion inverted PSC devices based on syn-SAM deliver power conversion efficiencies (PCEs) of 25.75% (certified 25.45%) and 22.76% (area: 0.105 cm 2 ) for 1.56  and 1.68 eV bandgap perovskites, respectively. Moreover, this approach is beneficial for the monolithic perovskite/silicon tandem solar cells based on fully textured surfaces of heterojunction (HJT) silicon bottom cells, affording PCEs of 31.56% (area: 1.07 cm 2 ) and 26.57% (area: 20.06 cm 2 ). All devices exhibit excellent long-term storage and thermal stability even under non-encapsulated conditions.}, archive = {J_ANGEW}, author = {Huiyao Zhao and Xiwen Zhang and Kai Zhang and Wenfeng Zhang and Rui Zhou and Yanbei Wei and Jun Qu and Yangdi Chen and Hongyu Li and Xueping Zong and Shantao Zhang and Mao Liang and Yuelong Huang and Haijin Li and Yingguo Yang and Wei Long and Yang Wang and Shangfeng Yang}, doi = {10.1002/anie.202504237}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202504237}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic self-assembled monolayers reinforce buried interface anchoring for high-efficiency tandem perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Mitochondria-targeting abasic site-reactive probe (mTAP) enables the manipulation of mitochondrial DNA levels. ANGEW, 64(36), e202502470. (www)

  @article{ , abstract = {Mitochondrial DNA (mtDNA) encodes essential genes for mitochondrial and cellular functions and acts as a cell signaling molecule in innate immune and inflammatory responses. Defects in mtDNA are implicated in a range of mitochondrial disorders and human diseases. Currently, no chemical strategy exists to prevent mtDNA loss under genotoxic stress. To address this, we developed a mitochondria-targeting probe (mTAP) that selectively reacts with key mtDNA repair intermediates–abasic (AP) sites. We confirmed that mTAP forms oxime conjugates exclusively with mitochondrial AP sites without conjugation with nuclear AP sites. Upon mTAP conjugation, DNA substrates containing AP sites were resistant to cleavage by AP endonuclease (APE1) and mitochondrial extracts. This conjugation significantly reduced the DNA-binding affinity of APE1 without affecting the DNA-binding activity of a mtDNA-packaging factor, mitochondrial transcription factor A (TFAM). Importantly, cellular experiments demonstrated that mTAP treatment alleviated the decrease in mtDNA and transcription product levels induced by mitochondrial AP site damage. Functional assays also demonstrated that mTAP treatment did not compromise mtDNA replication activity or increase the overall mtDNA damage level. These findings highlight the potential of mTAP as a valuable chemical tool to modulate mtDNA levels under genotoxic stress.}, archive = {J_ANGEW}, author = {Anal Jana and Yu-Hsuan Chen and Linlin Zhao}, doi = {10.1002/anie.202502470}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202502470}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mitochondria-targeting abasic site-reactive probe (mTAP) enables the manipulation of mitochondrial DNA levels}, volume = {64}, year = {2025}, }
• (2025). Ultra-fast self-powered heterojunction blue-light photodetector based on boronate-ester-linked COF-5. ANGEW, 64(36), e202502364. (www)

  @article{ , abstract = {Covalent organic framework materials have recently garnered significant interest from the scientific community due to their fascinating properties that include highly ordered porosity, structural versatility, high chemical and thermal stabilities, and facile surface modification. Herein, for the first time, we present the design and fabrication of a self-powered blue-light photodetector based on boronate-ester-linked 2D covalent organic framework (COF-5) film, synthesized using hexahydroxytriphenylene and 1,4-phenylenediboronic acid organic linkers. Specifically, we have developed a COF-5/n-Si photodetector that exhibits an ultra-short rise response time of 41 µs and a decay response time of 222 µs under 0 V bias. Our work integrated rapid response times and the distinctive benefit of self-powering, setting it apart from existing COF-based photodetectors.}, archive = {J_ANGEW}, author = {Shuangyin Gao and Rujun Tang and Ping Duan and Jin Tan and Shuoguo Yuan and Zhigao Dai and Jianmei Xu and Zhihong Yang and Wei Zhou and Auttaphon Chachvalvutikul and Kieran Aggett and Anatoly Zayats and Ouardia Akdim and Jian Sun and Graham Hutchings}, doi = {10.1002/anie.202502364}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202502364}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-fast self-powered heterojunction blue-light photodetector based on boronate-ester-linked COF-5}, volume = {64}, year = {2025}, }
• (2025). Polycation engineering in polymeric metal halides enables tunable and multicolor emission from single transition-metals. ANGEW, 64(36), e202502210. (www)

  @article{ , abstract = {Zero-dimensional metal halides have emerged as a versatile platform for the development of light-emitting materials, but achieving tunable or even multicolor emission from a material containing a single type of metal has proven highly challenging. Here, we leverage the “structural tolerance” of recently-developed polymeric metal halides to integrate two distinct coordination units of a single metal into a material, thereby achieving highly tunable optical properties in single-phase metal halides. By manipulating the steric hindrance of polycations, facilely adjustable green, red or bicolor emission can be realized in manganese bromides, which originates from controllable transformation from manganese-bromine tetrahedra into octahedra. This design principle is further extended to polymeric copper halides, wherein broad self-trapped exciton emissions derived from distinct copper-iodine polyhedrons allow the emission colors to be linearly tunable from blue to yellow, encompassing pure white light, by tailoring the composition, excitation wavelength, or temperature. This study opens avenues for facile and precise modulation of the optical properties of metal halides by exploiting the intrinsic coordinative diversity of metal elements.}, archive = {J_ANGEW}, author = {Shun-Shun Li and Pengfei Cheng and Huaxin Liu and Juntao Li and Jianyong Liu and Junsheng Chen and Kaifeng Wu}, doi = {10.1002/anie.202502210}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202502210}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polycation engineering in polymeric metal halides enables tunable and multicolor emission from single transition-metals}, volume = {64}, year = {2025}, }
• (2025). Metal-responsive up-regulation of bifunctional disulfides for suppressing protein misfolding and promoting oxidative folding. ANGEW, 64(36), e202502187. (www)

  @article{ , abstract = {The stress-responsive up-regulation process is a sophisticated biological response to maintain cellular homeostasis. In intracellular anti-oxidant systems, the expression level of oxidoreductases is up-regulated under oxidative stress, mitigating oxidative damage on biomolecules and enhancing protein folding capacity. Herein, inspired by the biological system, we developed a synthetic folding promotor whose reactivity is up-regulated under stress conditions. We conjugated two metal-binding 1,4,7,11-tetraazacyclotetradecane (cyclam) ligands and a redox-active disulfide to obtain cyclam-SS, whose reactivity can be enhanced under metal-induced stress. Metal coordination increased the redox potential of cyclam-SS, activating it as an oxidant. While Cu II ions severely hampered the oxidative folding of substrate polypeptides, cyclam-SS exhibited bifunctional folding-promoting properties, i) suppressing Cu II -mediated misfolding and aggregation, and ii) harnessing Cu II to enhance oxidative folding. Cyclam-SS was also useful for disulfide-bond formation to promote oxidative folding of pharmaceutical and pathological proteins, as demonstrated with proinsulin and superoxide dismutase 1 (SOD1). Furthermore, cyclam-SS protected cultured cells from copper-induced stress. Thus, we demonstrated the induction of the stress-responsive up-regulation process by a bifunctional folding promotor controlling the folding status of biologically important proteins under metal-induced stress. The strategy of “stress-responsive up-regulation” could aid the development of novel synthetic materials for treating intracellular stress and related disorders.}, archive = {J_ANGEW}, author = {Keita Mori and Tsubura Kuramochi and Motonori Matsusaki and Yuki Hashiguchi and Masaki Okumura and Tomohide Saio and Yoshiaki Furukawa and Kenta Arai and Takahiro Muraoka}, doi = {10.1002/anie.202502187}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202502187}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-responsive up-regulation of bifunctional disulfides for suppressing protein misfolding and promoting oxidative folding}, volume = {64}, year = {2025}, }
• (2025). Digital-twin-assisted insights into irreversible capacity and activation strategy power high-loading solid-state batteries. ANGEW, 64(36), e202502169. (www)

  @article{ , abstract = {In solid-state lithium-ion batteries, the fraction of active materials involved in electrode electrochemistry reduces with the increase of electrode thickness. Conventional wisdom suggests that the degree of reaction linearly decreases toward the current collector as in lithium-ion batteries, which is, however, limited by the high difficulty of experimental capture of operando charge and mass transport. Electrode dynamics simulations can provide space visualization but are usually based on simplified models. Herein, we build digital-twin electrodes with digital-space voxel microstructure based on synchrotron tomography, which transforms the electrode architecture from real space to digital space for the construction of precision models. From the digital model-driven simulation, we find an “lithium trapping” effect, stemming from susceptible lithium stuck in the solid electrolyte, triggers an inadequate reaction of the intermediate region of electrodes. Then, we construct locally accelerated ion paths activating the lithium trapping, indicating that this strategy can significantly guide the sustainable battery design for next-generation energy storage.}, archive = {J_ANGEW}, author = {Yecai Sun and Yanbin Ning and Zhuomin Qiang and Lizhi Xiang and Qingsong Liu and Chaoqun Zhang and Guoce Quan and Yan Zhang and Biao Deng and Geping Yin and Tiefeng Liu and Jiajun Wang and Shuaifeng Lou}, doi = {10.1002/anie.202502169}, journal = {Angewandte Chemie International Edition}, month = {9}, number = {36}, pages = {e202502169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Digital-twin-assisted insights into irreversible capacity and activation strategy power high-loading solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Reduction of CO2 accompanying ATP synthesis in polydopamine microreactors covered by lipid bilayers with ATPase. ANGEW, 64(35), e202583502. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583502}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202583502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Reduction of CO2 accompanying ATP synthesis in polydopamine microreactors covered by lipid bilayers with ATPase}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Merging photocatalysis with chiral lewis acid catalysis for enantioselective Hydrosilylation/Hydrogermylation of electron-deficient alkenes. ANGEW, 64(35), e202583501. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583501}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202583501}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Merging photocatalysis with chiral lewis acid catalysis for enantioselective Hydrosilylation/Hydrogermylation of electron-deficient alkenes}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Light-driven ratchet mechanism accelerates regioselective metal-cation exchange in a heterobimetallic helicate (Angew. chem. int. ed. 35/2025). ANGEW, 64(35), e202517049. (www)

  @article{ , archive = {J_ANGEW}, author = {Maximilian J. Notheis and Gregor Schnakenburg and Larissa K. S. von Krbek}, doi = {10.1002/anie.202517049}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202517049}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Light-driven ratchet mechanism accelerates regioselective metal-cation exchange in a heterobimetallic helicate (Angew. chem. int. ed. 35/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Thermodynamics of water displacement from binding sites and its contributions to supramolecular and biomolecular affinity (Angew. chem. int. ed. 35/2025). ANGEW, 64(35), e202516888. (www)

  @article{ , archive = {J_ANGEW}, author = {Jeffry Setiadi and Frank Biedermann and Werner M. Nau and Michael K. Gilson}, doi = {10.1002/anie.202516888}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202516888}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Thermodynamics of water displacement from binding sites and its contributions to supramolecular and biomolecular affinity (Angew. chem. int. ed. 35/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Unlocking dual recycling in photo-curable polycyanurate thermosets derived from bio-resources (Angew. chem. int. ed. 35/2025). ANGEW, 64(35), e202516887. (www)

  @article{ , archive = {J_ANGEW}, author = {Özgün Dağlar and Yi-Ru Chen and Željko Tomović}, doi = {10.1002/anie.202516887}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202516887}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Unlocking dual recycling in photo-curable polycyanurate thermosets derived from bio-resources (Angew. chem. int. ed. 35/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Precisely tuning photothermal and photodynamic effects of polymeric nanoparticles by controlled copolymerization”. ANGEW, 64(35), e202516366. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202516366}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202516366}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Precisely tuning photothermal and photodynamic effects of polymeric nanoparticles by controlled copolymerization”}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Confining asymmetrically coordinated cobalt single-Atoms/Clusters on holey MXene for ultrafast fenton-like catalysis (Angew. chem. int. ed. 35/2025). ANGEW, 64(35), e202516104. (www)

  @article{ , archive = {J_ANGEW}, author = {Xin Guo and Hao Zhang and Yunlong Wang and Yiyuan Yao and Chengming Xiao and Kechen Gu and Junwen Qi and Yujun Zhou and Yue Yang and Zhigao Zhu and Jiansheng Li}, doi = {10.1002/anie.202516104}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202516104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Confining asymmetrically coordinated cobalt single-Atoms/Clusters on holey MXene for ultrafast fenton-like catalysis (Angew. chem. int. ed. 35/2025)}, volume = {64}, year = {2025}, }
• (2025). Oriol planas. ANGEW, 64(35), e202514625. (www)

  @article{ , archive = {J_ANGEW}, author = {Oriol Planas}, doi = {10.1002/anie.202514625}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202514625}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oriol planas}, volume = {64}, year = {2025}, }
• (2025). Larissa k. s. von krbek. ANGEW, 64(35), e202514533. (www)

  @article{ , archive = {J_ANGEW}, author = {Larissa K. S. von Krbek}, doi = {10.1002/anie.202514533}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202514533}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Larissa k. s. von krbek}, volume = {64}, year = {2025}, }
• (2025). Concentration-adaptive electrocatalytic urea synthesis from CO2 and nitrate via porphyrin and metalloporphyrin MOFs. ANGEW, 64(35), e202513441. (www)

  @article{ , abstract = {Traditional urea synthesis via the Bosch–Meiser process suffers from high energy consumption and greenhouse gas emissions. Electrocatalytic urea production from carbon dioxide (CO 2 ) and nitrate (NO 3 − ) under ambient conditions offers a sustainable alternative, yet challenges persist due to variable NO 3 − concentrations and competing side reactions. Herein, we propose porphyrin metal-organic framework (PMOF) and Cu-porphyrin MOF (Cu-PMOF) catalysts for NO 3 − concentration-adaptive urea synthesis. Density functional theory (DFT) calculations reveal that PMOF weakly adsorbs *NO 2 via hydrogen bonding, favoring its coupling with *CO 2 , while Cu-PMOF strongly binds *NO 2 at Cu sites, facilitating spontaneous *NO/*CO coupling to form *OCNO intermediates under dilute NO 3 − conditions. Experimentally, PMOF achieves a urea yield of 28.6 µmol h −1 mg cat −1 and a Faradaic efficiency (FE) of 23.1% in 0.1 M NO 3 − , whereas Cu-PMOF outperforms in 0.05 M NO 3 − with a yield of 25.5 µmol h −1 mg cat −1 and FE of 52.7%. In situ spectroscopy and mechanistic study confirm distinct pathways: PMOF relies on stepwise coupling of *HNO 2 with *CO 2 , while Cu-PMOF enables consecutive *NO-*CO coupling. This work highlights adaptive electrocatalyst design for efficient C-N coupling, advancing sustainable urea synthesis.}, archive = {J_ANGEW}, author = {Yi Tan and Xiaokang Chen and Jian Yuan and Guan Sheng and Wei-Qiao Deng and Hao Wu}, doi = {10.1002/anie.202513441}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202513441}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concentration-adaptive electrocatalytic urea synthesis from CO2 and nitrate via porphyrin and metalloporphyrin MOFs}, volume = {64}, year = {2025}, }
• (2025). Metal-covalent organic frameworks: Design strategy, structure feature, and applications in energy storage. ANGEW, 64(35), e202513165. (www)

  @article{ , abstract = {Metal-covalent organic frameworks (MCOFs), which can integrate the properties of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), exhibit high stability, adjustable pore structures, and catalytic activity of metal sites owing to the synergistic interaction between metal sites and covalent backbones. In this regard, MCOFs have gained significant attention as promising electrode materials, where metal ions (M n+ ) function as molecular structure switches, providing MCOFs with diverse active sites and modifying their charge density by incorporating different M n+ , thereby imparting unique energy-storage properties to MCOFs. Furthermore, by optimizing the synthesis strategies of MCOFs, their topological and dimensional structures can be regulated to ensure the stability of the MCOFs. In the challenging landscape of energy storage, MCOFs have surpassed the performance limitations of traditional COFs. Through precise atomic-level control of metal sites and innovative design of dynamic covalent chemistry, they can significantly enhance the performance of batteries, achieving remarkable performance in lithium-ion batteries (LIBs), lithium–sulfur batteries, and other applications. This review systematically summarizes the research advancements of MCOFs in high-performance energy storage devices, including lithium-ion, Li–CO 2 , and Zn-ion batteries. In addition, it examines the synthesis strategies, structural regulation, and structural characteristics of MCOFs to address the challenges encountered in various energy storage devices.}, archive = {J_ANGEW}, author = {Lianchao Wang and Ruiying Fu and Chao Li and Xutian Yang and Cheng Zhang and Mingjun Ouyang and Kuaibing Wang and Qichun Zhang}, doi = {10.1002/anie.202513165}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202513165}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-covalent organic frameworks: Design strategy, structure feature, and applications in energy storage}, volume = {64}, year = {2025}, }
• (2025). Engineering neural stem cells with micropatches for improved therapy of traumatic brain injury. ANGEW, 64(35), e202512804. (www)

  @article{ , abstract = {Transplantation of neural stem cells (NSCs) holds promise for repairing traumatic brain injury (TBI) but their therapeutic performance is hindered due to the low efficient differentiation into neurons. Direct injection of differentiation modulators to the lesion site has limited improvement to neuronal differentiation as they tend to diffuse or be degraded. In the present study, we report a simple and versatile strategy to engineer the NSCs with a micropatch to improve their therapeutic performance in TBI treatment. The micropatches are fabricated through microcontact printing technique and can adhere to the membrane with negligible detachment or internalization within 14 days after surface modification. The micropatches on the cell membrane can move together with stem cells and sustainedly release retinoic acid, a neuronal differentiation modulator, to regulate the surrounding microenvironment of NSCs, improving their neuronal differentiation rate from 28.0% to 54.2%. The micropatch-engineered NSCs can be implanted into the injured brain tissue through a minimally invasive microinjection approach and show outperformance in repairing damaged neural tissue of TBI mice compared to normal stem cells. Overall, this work highlights a new pathway to engineer stem cells and holds great potential in nerve regeneration and neurodegenerative disease treatment.}, archive = {J_ANGEW}, author = {He Xia and Wenjuan Zhou and Dezheng Li and Fan Peng and Chao Wang and Liyang Yu and Jingyi Du and Yang Zheng and Yuanhua Sang and Yu Zhang and Lin Han and Hong Liu and Aijun Hao and Jichuan Qiu}, doi = {10.1002/anie.202512804}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202512804}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering neural stem cells with micropatches for improved therapy of traumatic brain injury}, volume = {64}, year = {2025}, }
• (2025). Is the smallest molecular trefoil knot actually the tightest one?. ANGEW, 64(35), e202512327. (www)

  @article{ , abstract = {Tightness engineering has evolved as an efficient strategy for the design of knotted, woven, and entangled molecules and materials with desired properties and functions since tightness is a primary parameter that determines the property of a knotted strand. However, as an attractive topic that inspires mathematicians, physicists, chemists, and biologists, whether the smallest knot is exactly the tightest one remains unaddressed experimentally. To tackle this challenge, a series of organic trefoil knots with the backbone-atom as short as 70 have been successfully synthesized by developing a new modular self-assembly approach in this study. To our great surprise, with the help of gradient tandem mass spectrometry, the quantitative tightness evaluation suggested that the molecular trefoil knot with a backbone crossing ratio (BCR) of 24.0 is even tighter than the one with a BCR of 23.3 (i.e., the smallest organic trefoil knot with the shortest ropelength synthesized so far), thus demonstrating an unexpected yet interesting odd-even effect to enhance the understanding of the tightness regulation of molecular knots.}, archive = {J_ANGEW}, author = {Wei-Tao Xu and Chenxing Guo and Yefei Jiang and Wei-Jian Li and Xiao-Qin Xu and Xue Li and Siqi Luo and Lianrui Hu and Xiujun Yu and Xiaopeng Li and Hai-Bo Yang and Wei Wang}, doi = {10.1002/anie.202512327}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202512327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Is the smallest molecular trefoil knot actually the tightest one?}, volume = {64}, year = {2025}, }
• (2025). Intermolecular Sp3C─H metalation of non-nucleophilic brønsted bases using simple lewis acids. ANGEW, 64(35), e202512254. (www)

  @article{ , abstract = {2,6-Di- tert -butyl substituted pyridines ( t Bu 2 -py) are widely used non-nucleophilic Brønsted bases. Their ubiquity is due to their highly hindered basic site and chemically robust nature. Herein we report that simple M 2 X 6 Lewis acids (M═Al or Ga, X═Cl, Br or I) effect intermolecular sp 3 C─H metalation of t Bu 2 -py bases under mild conditions. The sp 3 C─H metalated products can be converted in situ into ─BPin, ─iodo, ─bromo and ─hydroxy derivatives for further elaboration. Mechanistic investigations indicate that: i) a frustrated Lewis pair effects sp 3 C─H heterolysis to form the C─M bond and a protonated pyridine; ii) C─H metalation requires singly halide-bridged super-electrophilic M 2 X 6 dimers for sufficiently low barriers. Finally, sp 3 C─H metalation using M 2 X 6 is not limited to t Bu 2 -py bases. Thus, it is important to be aware of this facile sp 3 C─H functionalisation when using a range of non-nucleophilic Brønsted bases.}, archive = {J_ANGEW}, author = {Anna V. Schellbach and Dominic R. Willcox and Miriana Guarnaccia and Gary S. Nichol and Valerio Fasano and Michael J. Ingleson}, doi = {10.1002/anie.202512254}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202512254}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intermolecular Sp3C─H metalation of non-nucleophilic brønsted bases using simple lewis acids}, volume = {64}, year = {2025}, }
• (2025). Site-blocking strategy boosts H2S tolerance in platinum-based hydrogen oxidation catalysts. ANGEW, 64(35), e202512225. (www)

  @article{ , abstract = {Proton exchange membrane fuel cells (PEMFCs) show great potential for energy conversion, but their platinum-based hydrogen oxidation reaction (HOR) catalysts are easily and irreversibly poisoned by trace impurities like H 2 S, causing performance degradation with unclear mechanisms. Here, combining in situ Raman spectroscopy with theoretical calculations, we found that on pure Pt surfaces, H 2 S dissociates into S* and HS* intermediates that occupy active sites of continuous Pt atoms in an acidic solution under 50 ppm H 2 S/H 2 atmosphere. However, on PtRu alloy surfaces, while *OH species were observed on Ru sites, no sulfur-containing species were detected on Pt sites. Comparative experiments revealed that the sulfur-related Raman peaks of PtRu exhibited a redshift compared to Pt, indicating that Ru alloying weakens the *S adsorption on Pt sites through electronic effects. These results demonstrate that Ru not only creates discontinuous Pt sites to block sulfur adsorption but also significantly weakens sulfur binding through electronic modulation. Based on these insights, small-sized site-blocking PtRu/C catalysts were developed, exhibiting only 9.2% activity decay after 700s in 50 ppm H 2 S/H 2 atmosphere, a 4.3-fold improvement over commercial Pt/C catalysts (39.3% decay). This work provides fundamental understanding of H 2 S poisoning mechanisms and practical guidelines for designing robust, poison-resistant catalysts.}, archive = {J_ANGEW}, author = {Wei Kang and Tao Shen and Ying Wang and Jilong Xu and Chuansheng Ma and Yue Wang and Yue-Jiao Zhang and Jia-Bo Le and Yifan Ye and Jian-Feng Li and Jin-Chao Dong}, doi = {10.1002/anie.202512225}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202512225}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-blocking strategy boosts H2S tolerance in platinum-based hydrogen oxidation catalysts}, volume = {64}, year = {2025}, }
• (2025). Tuning Eley–Rideal mechanism in electrochemical acetylene semi-hydrogenation. ANGEW, 64(35), e202512218. (www)

  @article{ , abstract = {The Eley–Rideal (ER) mechanism is pivotal in heterogeneous catalysis processes such as fuel cells and electrolyzers, which rely heavily on the interaction between solution-phase and surface-phase species. In this study, we examine the semi-hydrogenation of acetylene to ethylene to explore the factors influencing the ER mechanism. We employed the density functional theory (DFT) to calculate the hydrogenation of acetylene on face-centered cubic metals and copper-based alloys. Microkinetic modeling identifies changes in the rate-determining steps of different alloys as electronegativity decreases. We then constructed the volcano plot for the adsorption energy toward C 2 H 2 and the reaction rate, which predicted that Cu 3 Au is the best candidate alloy for the C 2 H 2 semi-hydrogenation. Both extensive prior research and our experimental findings validated our volcano plot. Notably, our work points out the two key determinants of the ER mechanism: atomic activation and steric hindrance. For metals with weaker adsorption, steric hindrance primarily obstructs the ER mechanism, while for metals with stronger adsorption, the ER mechanism is hindered due to the challenge of atomic activation. Therefore, introducing weak adsorption sites into moderately adsorptive metals can improve the overall efficiency of the ER reaction by balancing these two factors.}, archive = {J_ANGEW}, author = {Chengyi Zhang and Jiguang Zhang and Zihao Jiao and Yanwei Lum and Ziyun Wang}, doi = {10.1002/anie.202512218}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202512218}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning Eley–Rideal mechanism in electrochemical acetylene semi-hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Orthogonal multiple hydrogen bonds of nucleobases enable precise tunability of DNA-polymer nanostructures. ANGEW, 64(35), e202512106. (www)

  @article{ , abstract = {DNA-polymer nanostructures manifest enhanced stability and chemical diversity for various applications such as sensing, imaging, and immune modulation. However, the functionality of the hydrophobic polymer in the core is often disregarded, leading to limited property tunability of DNA-polymer nanostructures. Herein, we have successfully fabricated tunable DNA-polymer nanostructures by harnessing orthogonal multiple hydrogen bonds (MHBs) within both the core and shell domains. Distinct DNA-polymer nanostructures, consisting of hydrophobic nucleobase-containing polymers and hydrophilic DNAs, have been rationally designed and successfully constructed. The DNA-polymer nanostructures undergo the controlled morphological transformation triggered by hydrophobic nucleobase-containing polymers and surface functionalization by hydrophilic DNA chains. Owing to the heterogeneous backbone structures, distinct repeat unit spacing, and different hydrophilicity, the robust MHB interactions for complementary DNAs and nucleobase-containing polymers are highly selective and orthogonal. Most significantly, the reported core-driven morphological transformation and surface functionalization of the shell layer are general to expand the structural and properties tunability of DNA nanostructures with different DNA sequences. This work provides an efficient and novel route to precisely modulating DNA-polymer core-shell nanostructures by exploiting the underexplored hydrophobic core through orthogonal MHBs.}, archive = {J_ANGEW}, author = {Yuan Xue and Huijuan Chen and Nan Yao and Siyu Guo and Ziyi Gui and Zan Hua}, doi = {10.1002/anie.202512106}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202512106}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orthogonal multiple hydrogen bonds of nucleobases enable precise tunability of DNA-polymer nanostructures}, volume = {64}, year = {2025}, }
• (2025). Probing multilevel chiroptical activity in organic supramolecular microcrystals for high-performance circularly polarized lasing. ANGEW, 64(35), e202512072. (www)

  @article{ , abstract = {Chiral organic materials are rapidly emerging as a promising platform for circularly polarized lasing. However, the lag in mechanistic research has severely hindered the development of organic circularly polarized lasers. Here, we attempt to probe multilevel chiroptical activity in organic supramolecular microcrystals for exploring high-performance circularly polarized lasing. The evolution of chiroptical activity is tracked spanning from chiral molecular monomers to dimers to supramolecular helices. The crucial roles of excimers and supramolecular helices in achieving high optical gain and large chiroptical activity are revealed. Accordingly, circularly polarized lasing with low thresholds and large dissymmetry factors is realized in the organic supramolecular microcrystals. Our work marks the beginning of mechanistic research on chirality induced circularly polarized lasing, which will initiate the rational design of chiral organic materials for circularly polarized lasing.}, archive = {J_ANGEW}, author = {Shizhe Ren and Zheng-Fei Liu and Penghao Li and Kang Wang and Jiannian Yao and Qing-Zheng Yang and Yong Sheng Zhao and Haiyun Dong}, doi = {10.1002/anie.202512072}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202512072}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing multilevel chiroptical activity in organic supramolecular microcrystals for high-performance circularly polarized lasing}, volume = {64}, year = {2025}, }
• (2025). A bioinspired diazafluorenone catalytic system for aerobic oxidative deamination of primary amines. ANGEW, 64(35), e202511937. (www)

  @article{ , abstract = {Copper amine oxidases (CAOs) catalyze aerobic oxidation of primary amines into carbonyl compounds, which is an important biological process as well as a useful transformation for organic synthesis. A new bioinspired organocatalyst, 1,8-diazafluoren-9-one (DFO), has been discovered, which exhibits impressive characteristics, including simple structure, high robustness, and strong electrophilicity, enabling it to effectively mimic the function of copper amine oxidases. Oxidative deamination of α-amino amides presents an attractive approach to access α-keto amides; however, it is difficult to achieve due to their electron-withdrawing nature and steric effect. The diazafluorenone displays high catalytic activity in this transformation, producing various biologically significant α-keto amides in moderate to excellent yields. Furthermore, the diazafluorenone catalyst is able to promote direct oxidation of benzylamines into aromatic aldehydes, instead of the generally formed product-reactant imines, which leads to no greater than 50% yields of the desired aldehydes. The current aerobic oxidative deamination proceeds via a pathway similar to the biological process, involving transamination, hydrolysis/aminolysis, and aerobic oxidation.}, archive = {J_ANGEW}, author = {Sheng Gong and Wenhu Zhang and Yongchang Song and Jianfeng Chen and Baoguo Zhao}, doi = {10.1002/anie.202511937}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511937}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bioinspired diazafluorenone catalytic system for aerobic oxidative deamination of primary amines}, volume = {64}, year = {2025}, }
• (2025). Reductive n2 cleavage and nitride insertion reactivity at molybdenum complexes supported by a rigid PNP pincer. ANGEW, 64(35), e202511887. (www)

  @article{ , abstract = {Metal-nitride species represent key reactive intermediates in reductive N 2 cleavage and functionalization. Toward a better understanding of nitride transfer reactivity, we present a series of Mo-nitride complexes supported by a rigid diphosphino-acridane pincer ligand. Notably, the stepwise reduction of a Mo IV Cl 3 complex under N 2 allows the isolation of a bridging diazenido intermediate as well as a dinuclear Mo-nitride species ( 4 ) accommodating a bridging N 2 moiety. This is the first example of a Mo(IV) nitride-N 2 species, and extensive 15 N-labeling studies were performed to characterize the bridging dinitrogen, diazenido, and nitride moieties. The structure of 4 adopts two orthogonal π-backbonding interactions between N 2 and two structurally rigidified Mo IV (N) fragments featuring a filled d π orbital. Effective π-backbonding from such a Mo IV (N) fragment leads to the isolation of PMe 3 , CO, and CN t Bu substituted analogues. Further, reactivity of the Mo-nitride species with π-acidic CO and isocyanide leads to the formation of Mo II -isocyanate and -carbodiimide species, respectively. Computational studies suggest that nitride carbonylation proceeds via an associative nitride insertion pathway, encouraging further studies in direct N 2 fixation to value-added products via nitride functionalization.}, archive = {J_ANGEW}, author = {Minjun Kim and Jeewhan Oh and Sanha Park and Hankyul Lee and Zee Hwan Kim and Jin Kim and Heui Beom Lee and Jonghoon Choi and Yunho Lee}, doi = {10.1002/anie.202511887}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511887}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reductive n2 cleavage and nitride insertion reactivity at molybdenum complexes supported by a rigid PNP pincer}, volume = {64}, year = {2025}, }
• (2025). Nylon-6 precursor electrosynthesis from low-concentration NO via carbon-enhanced NO adsorption and improved mass transfer. ANGEW, 64(35), e202511865. (www)

  @article{ , abstract = {Cyclohexanone oxime electrosynthesis from low-concentration NO is important but suffers from low Faraday efficiency and current density because of severe competitive hydrogen and ammonia evolution reactions. Here, porous carbon-supported ultrasmall Ag nanoparticles are designed to achieve 85.5% FE at a partial current density of 100 mA cm −2 for cyclohexanone oxime with a 3% NO concentration, outperforming pure Ag nanoparticles. Mechanistic studies reveal that porous carbon can optimize the NO transport path and H 2 O molecule distribution on the catalyst surface, accelerating the reaction dynamics for cyclohexanone oxime electrosynthesis and suppressing ammonia and hydrogen formation. This work paves the way for accessing low-concentration gaseous reactants for various catalytic reactions.}, archive = {J_ANGEW}, author = {Xinyu Liu and Chuanqi Cheng and Jinghui Zhao and Bin Zhang and Yongmeng Wu}, doi = {10.1002/anie.202511865}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511865}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nylon-6 precursor electrosynthesis from low-concentration NO via carbon-enhanced NO adsorption and improved mass transfer}, volume = {64}, year = {2025}, }
• (2025). A 3.8 v quaternary ammonium-based dual-ion battery enabled by a conjugated ladder polymer. ANGEW, 64(35), e202511864. (www)

  @article{ , abstract = {Rechargeable batteries based on nonmetal charge carriers like NH 4 + recently have attracted intensive attention due to high safety, environmental friendliness, low cost, and fast kinetics. However, NH 4 + electrolytes suffer from a narrow electrochemical potential window, making it challenging to construct high-voltage and energy-dense devices. Here we report a quaternary ammonium (NR 4 + )-based dual-ion battery (DIB) working at a high voltage of 3.8 V, which was enabled by a conjugated ladder polymer poly(benzobisimidazobenzophenanthroline) (BBL) anode for NR 4 + storage and a graphite cathode for anion uptake. The BBL functions as an efficient NR 4 + host by carbonyl/enol transformation, delivering a high capacity of 120 mAh g −1 , low average potential, high stability, and excellent rate performance. In the redox process, the electronic and ionic conductivities of BBL change periodically, accompanied by the formation of radical anion ( ●− ) and diradical dianion ( 2●− ). In combination with an anion-intercalation graphite cathode, the assembled graphite//BBL DIB exhibits a maximum energy/power density up to 232 Wh kg −1 and 6865 W kg −1 based on mass of graphite, superior rate performance, and high cycling stability without capacity attenuation. Our work demonstrates the feasibility of NR 4 + as cation carrier and its efficient host, which will inspire novel designs for high-performance nonmetallic energy storage devices.}, archive = {J_ANGEW}, author = {Jian Zhang and Qing Lang and Evgenia Dmitrieva and Fang Chen and Jiayuan Yu and Yixiao Yang and Liang Chen and Gang Wang}, doi = {10.1002/anie.202511864}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A 3.8 v quaternary ammonium-based dual-ion battery enabled by a conjugated ladder polymer}, volume = {64}, year = {2025}, }
• (2025). Suppressing halide segregation of wide bandgap perovskite by interface molecular coordination for high-performance all-perovskite tandem solar cells. ANGEW, 64(35), e202511743. (www)

  @article{ , abstract = {Hole transporting layers made by self-assembled molecules (SAMs) are emerging as promising hole transporting materials (HTMs) for perovskite-based tandem solar cells, owing to their reduced parasitic absorption and effective carrier extraction. However, perovskite films grown on HTM substrates typically exhibit a high defect density, which adversely affects device performance. In this study, we investigated the film growth kinetics of wide-bandgap perovskite on monolayer material substrates and uncovered a halide phase segregation in the initial nucleation stage during crystal growth kinetics at the interface, which brings small grain sizes and significant lattice strain within the perovskite film. To address this issue, we introduced a biphosphate-substituted molecule on the HTM surface to coordinate with PbBr 2 that suppresses halide phase segregation, leading to improved crystallographic orientation and a reduction in defect density. As a result, the wide-bandgap (1.77 eV) perovskite solar cells (PSCs) achieved a power conversion efficiency (PCE) of 19.5% with an open-circuit voltage of 1.35 V, while tandem devices reached an impressive efficiency of 28.65%.}, archive = {J_ANGEW}, author = {Wenzhuo Li and Gaoqi Liu and Xin Wen and Xianyuan Jiang and Haobo Wu and Mingyu Ma and Wei Zhou and Hao Liang and Qilin Zhou and Yunlong Liu and Ruiqi Xu and Wenjing Wang and Zhenhuang Su and Wenjia Zhou and Xingyu Gao and Zhijun Ning}, doi = {10.1002/anie.202511743}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511743}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Suppressing halide segregation of wide bandgap perovskite by interface molecular coordination for high-performance all-perovskite tandem solar cells}, volume = {64}, year = {2025}, }
• (2025). Acetone derivatives for nickel-catalyzed methylation, trideuteromethylation, and 13C-methylation of (Hetero)Aryl chlorides. ANGEW, 64(35), e202511648. (www)

  @article{ , abstract = {The development of low-cost, readily available, and broadly applicable reagents for the methylation, trideuteromethylation, and 13 C-methylation of aryl chlorides is crucial. Using acetone and its isotopic derivatives as feedstocks, we have prepared the methylating, trideuteromethylating, and 13 C-methylating agents TDTP (2-(1,5,5-trimethyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridine), TDTP-CD 3 , and TDTP-¹ 3 CH 3 . Under nickel catalysis and without any additional redox reagent, these reagents efficiently methylate a wide range of (hetero)aryl chlorides, chlorine-containing complex molecules and phenolic derivatives, showing efficient functional-group tolerance and scalability; they, therefore, hold great promise for drug discovery and complex molecule synthesis. Mechanistic studies indicate that the reaction begins with nickel-catalyzed generation of a methyl radical, followed by radical cross-coupling.}, archive = {J_ANGEW}, author = {Jingsheng Li and Yi Xiao and Zhenyu Li and Yonggang Yan and Geyang Song and Gang Li and Jianyang Dong and Chao Wang and Tengfei Kang and Dong Xue}, doi = {10.1002/anie.202511648}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511648}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Acetone derivatives for nickel-catalyzed methylation, trideuteromethylation, and 13C-methylation of (Hetero)Aryl chlorides}, volume = {64}, year = {2025}, }
• (2025). An atomically precise copper cluster nanoreactor for efficient catalysis in chemical fixation of low-concentration CO2. ANGEW, 64(35), e202511580. (www)

  @article{ , abstract = {Chemical fixation of CO 2 with propargylic amines/alcohols into high value-added fine chemicals represents promising and practical routes for CO 2 resource utilization, but it remains a great challenge to achieve low-concentration CO 2 conversion in both reactions through one single catalytic system. Herein, a robust copper cluster [(C 6 H 15 NH)(Cu 8 L 8 I)] ( I@Cu 8 ) with nanosized cavities has been constructed. Importantly, the I@Cu 8 cluster as a nanoreactor can efficiently catalyze the chemical conversion of both propargylic amines and propargylic alcohols with CO 2 at simulated flue gas concentrations, due to the unique substrate enrichment effect of its well-defined nanocavities. Catalytic mechanism investigation and DFT calculations illustrate that the excellent catalytic performance originates from the simultaneous activation of alkynyl (─C≡CH) bonds and amino/hydroxyl (─NHR/─OH) groups in the I@Cu 8 catalytic system, in which the I@Cu 8 -substrate intermediates have been confirmed through ESI-MS analysis. Impressively, this is the first example of a cluster-based nanoreactor catalyst for low-concentration CO 2 cyclization reactions with both propargylic amines and propargylic alcohols. This work provides a foundation for the construction of metal cluster-based catalysts for CO 2 conversion into valuable chemicals.}, archive = {J_ANGEW}, author = {Wan-Zhen Qiao and Bing-Jie Xue and Rui Wang and Yuan Yang and Shuang-Quan Zang}, doi = {10.1002/anie.202511580}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511580}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An atomically precise copper cluster nanoreactor for efficient catalysis in chemical fixation of low-concentration CO2}, volume = {64}, year = {2025}, }
• (2025). Stepwise post-modification of pyridine-imine COFs for enhanced hydrolytic stability and proton conductivity. ANGEW, 64(35), e202511559. (www)

  @article{ , abstract = {Emerging as a type of promising material for proton conduction, covalent organic frameworks (COFs) assembled from dynamic imine bonds face a challenge of surmounting hydrolytic instability to achieve long-term performance in humid environments. In this work, we report a post-synthetic strategy to simultaneously enhance the hydrolytic stability and hydrophilicity of a pyridine-imine-based COF, COF-LIFM7, without compromising its crystallinity and porosity. A bifunctional monomer containing amino and acetal groups was employed to construct the primary framework, which was subsequently modified via amide formation and pyridine N-oxidation to yield COF-LIFM7-Amide and COF-LIFM7-Amide-N + O − . These stepwise modifications increased the polarity and hydrogen-binding sites within COF pores to improve water affinity, leading to a three-order-of-magnitude enhancement in the proton conductivity for COF-LIFM7-Amide-N + O − , reaching 1.9 × 10 −3 S cm −1 at 95% relative humidity and 70 °C. This study highlights a generalizable post-synthetic approach for tuning the pore chemistry of COFs to achieve high performance in proton-conducting applications under humid conditions.}, archive = {J_ANGEW}, author = {Hongfei Wang and Wen-Na Jiao and Wei-De Zhu and Si Huang and Xiao-Chun Lin and Ting Chen and Yanan Fan and Fangzheng Chen and Hai-Sen Xu and Mei Pan and Cheng-Yong Su}, doi = {10.1002/anie.202511559}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511559}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stepwise post-modification of pyridine-imine COFs for enhanced hydrolytic stability and proton conductivity}, volume = {64}, year = {2025}, }
• (2025). Asymmetric, corner-sharing CuO5 and CuO6 motifs in cu-based metallic perovskite oxides boosting asymmetric C─C coupling for CO2 electroreduction to c2+. ANGEW, 64(35), e202511546. (www)

  @article{ , abstract = {Cu-based perovskite oxides feature significant potential for CO 2 electroreduction (CO 2 RR) but encounter insufficient C 2+ selectivity primarily due to the inherent symmetric charge distribution at Cu sites hindering asymmetric C─C coupling. Here we report a unique type of Cu-based metallic perovskite oxides with asymmetric, corner-sharing CuO 5 and CuO 6 motifs to boost asymmetric C─C coupling for efficient CO 2 -to-C 2+ conversion. For the proof-of-concept catalyst of La 0.8 Ba 0.2 CuO 3-δ , their ordered, corner-sharing CuO 5 pyramids and CuO 6 octahedra feature localized charge density redistribution, creating abundant asymmetric Cu─Cu dual sites with distinct electronic structures and also strengthening Cu─O covalency. In CO 2 RR (in both alkaline and acidic media), La 0.8 Ba 0.2 CuO 3-δ greatly promotes C 2+ formation while producing negligible CH 4 , showing a Faradaic efficiency ratio (C 2+ to CH 4 ) of up to 180. Moreover, La 0.8 Ba 0.2 CuO 3-δ , achieving a remarkable C 2+ Faradaic efficiency of 85.0% at 400 mA cm −2 , together with well-boosted stability, outperforms previously reported Cu-based-perovskite catalysts. Our experiments and theoretical calculations attribute the superb performance mainly to the following factors: the asymmetric CuO 5 ─CuO 6 sites promoting differentiated *CO adsorption/hydrogenation to favor asymmetric *CO─*CHO coupling; the strengthened Cu─O covalency stabilizing the Cu sites. Extending this strategy to two additional pairs of Cu-based perovskite oxides generates similarly successful results.}, archive = {J_ANGEW}, author = {Yu Zhang and Hongyan Zhao and Junjie Zhu and Zitao Chen and Xiangjian Liu and Zhenbao Zhang and Lei Shi and Xuezeng Tian and Heqing Jiang and Yongfa Zhu and Jiawei Zhu}, doi = {10.1002/anie.202511546}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511546}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric, corner-sharing CuO5 and CuO6 motifs in cu-based metallic perovskite oxides boosting asymmetric C─C coupling for CO2 electroreduction to c2+}, volume = {64}, year = {2025}, }
• (2025). Sulfur mediated interfacial proton-directed transfer boosts electrocatalytic nitric oxide reduction to ammonia over dual-site catalysts. ANGEW, 64(35), e202511398. (www)

  @article{ , abstract = {Electrocatalytic nitric oxide reduction reaction (NORR) for ammonia (NH 3 ) synthesis represents a sustainable strategy that simultaneously realizes the nitrogen cycle and resource integration. The key issue hindering the NORR efficiency is accelerating proton (*H) transfer to facilitate NO hydrogenation while inhibiting the hydrogen evolution reaction (HER). Herein, we demonstrate an interface-engineered sulfur-mediated Cu@Co electrocatalyst (S-Cu@Co/C) that boosts NORR performance through dual modulation of electronic structure and proton transfer on active sites. A comprehensive program of experimental and theoretical calculations was employed to discover that sulfur incorporation induces electron redistribution in the Cu–Co interface, creating electron-rich sulfur and electron-deficient metals. This electronic configuration synergistically enhances NO adsorption on Cu sites and promotes water dissociation on Co sites. More critically, sulfur could direct the rapid transfer of *H from Co to Cu sites, thereby accelerating the NO hydrogenation and suppressing HER. Consequently, S-Cu@Co/C achieves an NH 3 yield rate of 655.3 µmol h −1 cm −2 in a flow cell and a Faradaic efficiency of 92.4% in an H-cell. Remarkably, the catalyst could maintain continuous electrolysis tests and steady NH 3 yield up to 100 h. This work provides innovative insights into the fabrication of efficient electrocatalysts via heteroatom-mediated interfacial engineering strategies.}, archive = {J_ANGEW}, author = {Zhenlin Wang and Haiyan Duan and Wenqiang Qu and Donglin Han and Xingchi Li and Li Zhu and Xuan Jiang and Danhong Cheng and Yongjie Shen and Ming Xie and Emiliano Cortes and Dengsong Zhang}, doi = {10.1002/anie.202511398}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511398}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sulfur mediated interfacial proton-directed transfer boosts electrocatalytic nitric oxide reduction to ammonia over dual-site catalysts}, volume = {64}, year = {2025}, }
• (2025). Remote and spatiotemporal modulation of supramolecular self-assembly of croconaine dyes via NIR laser irradiation. ANGEW, 64(35), e202511365. (www)

  @article{ , abstract = {Supramolecular polymerization holds great promise for the fabrication of well-defined nanostructures. However, achieving precise spatiotemporal control over the dynamic assembly of supramolecular polymers using external stimuli remains a significant challenge. Here, we present a near-infrared (NIR) laser irradiation strategy that exploits the intrinsic photothermal properties of croconaine-based molecular building blocks to modulate the aggregation–dissociation equilibrium of seeds, thereby enabling the formation of supramolecular polymers and copolymers. Light irradiation provides enhanced tunability through adjustments in laser power, irradiation time, and wavelength. Notably, the spatial precision afforded by laser irradiation allows for localized seed dissociation, offering a new approach for spatially controlled supramolecular polymerization. This method also enables efficient light-mediated gel formation, spatially selective sol–gel transitions, and healing in supramolecular organogels. These findings demonstrate a light-responsive strategy for regulating supramolecular polymerization and open new avenues for constructing nanomaterials with programmable structures and functions.}, archive = {J_ANGEW}, author = {Yangge Ren and Juanjuan Gao and Tiantian Cai and Linyuan Liu and Hao Huang and Yujia Guo and Xinyu Hou and Yue Lu and Lin Jia}, doi = {10.1002/anie.202511365}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511365}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote and spatiotemporal modulation of supramolecular self-assembly of croconaine dyes via NIR laser irradiation}, volume = {64}, year = {2025}, }
• (2025). Cobalt-catalyzed stereodivergent semihydrogenation of alkynes: Synthesis of E- and Z-alkenes. ANGEW, 64(35), e202511269. (www)

  @article{ , abstract = {Transition metal-catalyzed semihydrogenation of alkynes is one of the most efficient, sustainable, and environmental-friendly strategies for accessing stereoisomerically pure olefins. Herein, we report a tridentate nitrogen-containing ligand (8-OIQ) promoted cobalt-catalyzed stereodivergent semihydrogenation of internal alkynes; a series of Z - and E -alkenes could be synthesized with high stereoselectivity. Besides, this protocol exhibits excellent functional group tolerance and operates under mild reaction conditions (1 bar H 2 , room temperature). A preliminary mechanistic study revealed that acetonitrile plays an important role in suppressing over-reduction and controlling the stereoselectivity in this transformation.}, archive = {J_ANGEW}, author = {Xiang Ren and Peng Lu and Chenggong Zheng and Yong Wang and Zhan Lu}, doi = {10.1002/anie.202511269}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-catalyzed stereodivergent semihydrogenation of alkynes: Synthesis of E- and Z-alkenes}, volume = {64}, year = {2025}, }
• (2025). Confining asymmetrically coordinated cobalt single-Atoms/Clusters on holey MXene for ultrafast fenton-like catalysis. ANGEW, 64(35), e202511266. (www)

  @article{ , abstract = {Developing single-atom catalysts (SACs) with asymmetric coordination configurations is essential for enhancing peroxymonosulfate (PMS) activation in Fenton-like reactions. However, precisely regulating the electronic structure and coordination environment of metal centers to further improve activation kinetics remains a key challenge. Herein, we designed asymmetric CoN 1 O 2 single atoms (SAs) sites and Co nanoclusters (NCs) that were spatially confined in highly graphitized carbon layers and supported on holey MXene nanosheet (Co SA-NC /H 20 MX) via a dual-coordination microenvironment strategy. The Co SA-NC /H 20 MX catalyst demonstrated exceptional performance on bisphenol A (BPA) removal, achieving a corrected rate constant ( k value ) of 2750 min −1 M −1 and a total organic carbon removal efficiency of 78.2%. Mechanistic studies revealed that BPA removal was dominated by a nonradical electron transfer process (ETP, ∼100%), which facilitated rapid polymerization of BPA. Density functional theory calculations demonstrated that Co NCs synergistically enhanced the ability of asymmetric CoN 1 O 2 SAs sites to adsorb and activate PMS, significantly accelerating interfacial charge transfer. Furthermore, a catalytic membrane fabricated by crosslinking of Co SA-NC /H 20 MX and graphene achieved 100% BPA removal in single-pass mode with a hydraulic retention time of just 40 ms over 24 h of continuous operation. This work provides new insights into designing high-performance catalysts for pollutant removal via ETP-driven polymerization pathways.}, archive = {J_ANGEW}, author = {Xin Guo and Hao Zhang and Yunlong Wang and Yiyuan Yao and Chengming Xiao and Kechen Gu and Junwen Qi and Yujun Zhou and Yue Yang and Zhigao Zhu and Jiansheng Li}, doi = {10.1002/anie.202511266}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511266}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Confining asymmetrically coordinated cobalt single-Atoms/Clusters on holey MXene for ultrafast fenton-like catalysis}, volume = {64}, year = {2025}, }
• (2025). Fused-heterocycle-linked covalent organic frameworks with enhanced chemical and photochemical stability for photocatalysis. ANGEW, 64(35), e202511245. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have attracted significant interest for their potential in photocatalytic solar fuel generation. However, their intrinsic stability—particularly the photochemical stability, which influences the durability of their photocatalytic performance—remains a critical challenge. Here, we present the construction of four robust fused-heterocycle thiazole-linked COFs (TZ-COFs 14–17) through a facile one-pot three-component reaction using chrysene-6,12-diamine, aldehydes, and sulfur monomers. The incorporation of thiazole linkages within the fused-ring building blocks imparts exceptional chemical and photochemical stability to these COFs. They demonstrate high stability in strong acid (12 M HCl), strong base (12 M KOH and 1 M MeONa), reducing (1 M NaBH 4 ), and oxidizing (1 M H 2 O 2 ) agents, along with superior photostability under light degradation tests. Significantly, the in situ formed thiazoles introduce new, robust protonation sites compared to commonly used imine linkages, which improve the hydrophilicity, expand the range of light absorption, and lower the exciton binding energy of the framework. TZ-COF-17 achieves an impressive hydrogen evolution rate of up to 33.27 mmol g −1 h −1 , surpassing many previously reported COF photocatalysts.}, archive = {J_ANGEW}, author = {Zhifang Jia and Na Ji and Jing Qi and Tingxia Wang and Yu Che and Zhixiang Zhao and Jincheng Zhao and Ziyang Jiao and Kewei Wang and Weiwei Zhang and Wei-Hong Zhu}, doi = {10.1002/anie.202511245}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511245}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fused-heterocycle-linked covalent organic frameworks with enhanced chemical and photochemical stability for photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Stable acrylamide-linked covalent organic frameworks via mannich polymerization for efficient gold recovery from complex E-waste leachates. ANGEW, 64(35), e202511163. (www)

  @article{ , abstract = {Achieving both high stability and selectivity remains a critical challenge in covalent organic frameworks (COFs) for efficient gold recovery. Herein, we present a one-step Mannich-type three-component polymerization involving 1,3,5-triformylbenzene, Meldrum's acid, and aromatic diamines to construct a series of acrylamide-linked COFs (TFB-PD-M, TFB-ND-M, and TFB-AD-M). The incorporation of acrylamide linkages enhances π-conjugation and backbone rigidity, thereby yielding COFs with high crystallinity, permanent porosity, and exceptional chemical and thermal stability under extreme conditions. Importantly, the dual coordination sites (C═O and N─H) within the acrylamide units enable robust and selective Au 3+ binding through synergistic hydrogen bonding and chelation. Notably, TFB-AD-M achieves 98.5% selective Au 3+ recovery from complex electronic waste leachates, even in the presence of competing metal ions. This work introduces a robust linkage strategy that not only improves COF stability but also facilitates selective metal capture for resource recovery.}, archive = {J_ANGEW}, author = {Rui Zhang and Cheng-Peng Niu and Nai-Huai Dong and Ru-Ping Liang and Li-Ling Chen and Yun-Peng Wu and Ying-Ying Xiao and Ying-Ao Wang and Xiao-Xing Wang and Zhi-Hai Peng and Jian-Ding Qiu}, doi = {10.1002/anie.202511163}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511163}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable acrylamide-linked covalent organic frameworks via mannich polymerization for efficient gold recovery from complex E-waste leachates}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic reduction of CO2 to CO in 100%: The synergistic effect of nickel and europium in heterometallic clusters. ANGEW, 64(35), e202511126. (www)

  @article{ , abstract = {Heterometallic transition-rare earth metal (3d-4f) clusters with synergistic catalytic activity are rarely identified. Herein, two families of closely related 3d-Eu clusters were designed to analyze the role of Eu(III) ions during the photocatalytic reduction of CO 2 into CO. The [M 24 Eu 8 ] family, where M = Co or Ni, shows much lower activity (CO production < 2078 µ mol g −1 h −1 ) compared to the [M 24 Eu 10 ] family (CO production > 5838 µ mol g −1 h −1 ). This is due to the two additional Eu(III) ions in the apical position of the latter which are very active for converting CO 2 into CO. Moreover, we found the nickel analogues are better than the cobalt ones, especially for [Ni 24 Eu 10 ] which exhibits 100% CO selectivity and very high efficacy of 6545.3 µ mol g −1 h −1 , while the [Co 24 Eu 10 ] only shows 55% CO selectivity. Therefore, the coexistence of both apical Eu(III) and Ni(II) ions has been experimentally revealed to be critical for this exceptional catalytic performance of the [Ni 24 Eu 10 ] cluster. As such, this work unambiguously reveals a synergistic effect of bimetallic catalysts and may open a new avenue for more sophisticated reaction design by using the heterometallic coordination clusters.}, archive = {J_ANGEW}, author = {Kai-Peng Bai and Wei-Peng Chen and Meng-Di Cui and Yan-Zhen Zheng}, doi = {10.1002/anie.202511126}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202511126}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic reduction of CO2 to CO in 100%: The synergistic effect of nickel and europium in heterometallic clusters}, volume = {64}, year = {2025}, }
• (2025). Deciphering tryptophan oxygenation: Key modulators of 2-oxindole formation in MarE. ANGEW, 64(35), e202510848. (www)

  @article{ , abstract = {MarE, a heme-dependent aromatic oxygenase with a histidyl axial ligation, catalyzes the monooxygenation of β-methyl- l -tryptophan to form a 2-oxindole scaffold central to maremycin biosynthesis. Although structurally similar to tryptophan 2,3-dioxygenase (TDO), which initiates l -tryptophan catabolism via dioxygenation, MarE exhibits distinct reactivity modulated by ascorbate. While ascorbate has no effect on TDO, it promotes selective monooxygenation by MarE. In its absence, MarE favors dioxygenation and formation of pyrroloindoline products, revealing latent catalytic versatility. Active-site loop sequences differ between the two enzymes, SLGGR in MarE versus GTGGS in TDO, prompting loop-swapping experiments to probe structure-function relationships. Substituting GTGGS in TDO to MarE-like sequences (GTGGA or SLGGS) shifted reactivity toward monooxygenation and formation of C3-hydroxylated, non-oxindole products that underwent further cyclization into tricyclic structures. Conversely, replacing SLGGR in MarE with GTGGS resulted in enhanced C2,C3-dioxygenation nearly 4-fold. These results underscore the active-site loop as a key determinant of oxidation outcome, alongside the modulatory role of ascorbate. By revealing the true catalytic identity of MarE and delineating the roles of small-molecule effectors and loop architecture, this study advances mechanistic understanding and predictive capabilities within the oxygenase superfamily.}, archive = {J_ANGEW}, author = {Romie C. Nguyen and Inchul Shin and Aimin Liu}, doi = {10.1002/anie.202510848}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510848}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering tryptophan oxygenation: Key modulators of 2-oxindole formation in MarE}, volume = {64}, year = {2025}, }
• (2025). Self-adapting lattice respiration enabled by crystal design and d-p orbital hybridization toward highly stable rechargeable aluminum batteries. ANGEW, 64(35), e202510773. (www)

  @article{ , abstract = {Rechargeable aluminum batteries (RABs) are promising for large-scale energy storage due to the appealing three-electron transfer feature, low cost, and high safety. However, the strong electrostatic interaction between Al 3+ and host lattice induces severe lattice distortion and structural collapse, leading to poor cycle stability in RABs. Herein, we develop a new-type FeWO 4 cathode with a comprehensive consideration of the crystal structure and electronic structure. The 3D open framework and strong W─O covalent network of the FeWO 4 greatly improve the storage of high charge density Al 3+ . Moreover, the d - p orbital hybridization between the transition metal and oxygen facilitates electron delocalization, which effectively weakens the interaction with the trivalent cation (Al 3+ ). Importantly, combining in situ characterizations and theoretical calculations, it is demonstrated that as-prepared cathode exhibits a “self-adapting lattice respiration” (SALR) effect. Specifically, the reversible W–O bond elongation/compression (Δ d ≈ 0.05 Å) during cycling reduces lattice strain and confines volume expansion to less than 3%. As results, the FeWO 4 cathode delivers a high capacity of 192 mAh g −1 at 500 mA g −1 and long cycle life of over 2300 cycles with quiet low capacity decay of 0.01% per cycle in RABs.}, archive = {J_ANGEW}, author = {Huaizhi Wang and Yu Li and Bo Long and Shuqiang Li and Xueying Lu and Shijie Zhou and Feng Wu and Ying Bai and Chuan Wu}, doi = {10.1002/anie.202510773}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510773}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-adapting lattice respiration enabled by crystal design and d-p orbital hybridization toward highly stable rechargeable aluminum batteries}, volume = {64}, year = {2025}, }
• (2025). S-doped Ag–Sn alloy hollow microbox for high-performance CO2 electroreduction to formate. ANGEW, 64(35), e202510743. (www)

  @article{ , abstract = {The dynamic catalyst's restructuring creates a new catalytic surface that is essential for boosting the efficiency of electrochemical carbon dioxide reduction reaction (CO 2 RR). In this work, we synthesize Ag-decorated SnS 2 hollow microboxes using a coprecipitation method followed by a hydrothermal treatment. Based on a collection of in-situ/ex-situ characterizations including in-situ Raman spectroscopy, rapid freeze-quench (RFQ) 119 Sn Mössbauer spectroscopy, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS), we discover that the Ag-decorated SnS 2 (Ag@SnS 2 ) hollow microboxes undergo dynamic reduction and reconstruction during the electrochemical CO 2 RR, leading to the in-situ formation of S-doped Ag–Sn alloy (S-Ag 3 Sn/Sn) hollow microboxes. This transformation results in a remarkable formate selectivity of 92.4% with a formate partial current density of 97.3 mA·cm −2 at −0.8 V versus RHE in an H-cell. In-situ attenuated total reflection surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) measurements and density functional theory (DFT) calculations indicate that both S-doping and Ag–Sn alloying enhance the CO 2 adsorption and improve the stability of *OCHO intermediate. This work offers a facile strategy for designing highly active and selective electrocatalyst for CO 2 RR.}, archive = {J_ANGEW}, author = {Wenwen Zhang and Qing Mao and Jie Ding and Qi Liu and Shifu Wang and Jiuyi Wang and Xuning Li and Hongbin Yang and Bin Liu}, doi = {10.1002/anie.202510743}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510743}, shortjournal = {Angew. Chem. Int. Edit.}, title = {S-doped Ag–Sn alloy hollow microbox for high-performance CO2 electroreduction to formate}, volume = {64}, year = {2025}, }
• (2025). Local electric field microenvironment-induced dynamic spatial confinement to stabilize i+ toward high-mass-loading and stable Zinc–Iodine batteries. ANGEW, 64(35), e202510737. (www)

  @article{ , abstract = {Four-electron iodine conversion chemistry (I −/ I 2 /I + ) endows zinc–iodine batteries with competitive energy density. The stability of I + conversion relies on its interaction with sufficient nucleophilic species (e.g., Cl − , Br − ). However, under high iodine loading, nucleophilic species fail to afford sufficient coordination strength and number within thick iodine cathode to stabilize I + , thus compromising the high-voltage plateau and capacity. Here, we effectively spatially confine nucleophilic species (Cl − ) on the cathode by ─C─N + -induced localized electric field (LEF) microenvironment in polyquaternary ammonium iodide (PDDA-I). Spatial confinement maximizes Cl − concentration on the cathode ensuring highly reversible I 0 /I + conversion, even in the low-concentrated ZnCl 2 addition and high iodine loading. Importantly, the dynamically regulated Cl − maintains a balance with iodine species at the ─C─N + sites during cycling, effectively limiting the shuttling effect of polyiodides. Consequently, even adopting a high iodine loading of 16.03 mg cm −2 , the PDDA-I still maintains a distinct four-electron-conversion dual voltage plateau with a remarkable capacity of 4.97 mAh cm −2 . An impressive lifespan of 10 000 cycles is achieved at 12.6 mg cm −2 with a capacity decay of 0.0012% per cycle, exceeding conventional iodine cathodes by 20-fold. This work provides an important reference for high-performance four-electron conversion zinc–iodine batteries at high iodine loading.}, archive = {J_ANGEW}, author = {Liting Chen and Song Huang and Zhenfeng Feng and Zhenxin Lin and Haolong Huang and Minghui Ye and Yufei Zhang and Zhipeng Wen and Yongchao Tang and Xiaoqing Liu and Cheng Chao Li}, doi = {10.1002/anie.202510737}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510737}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Local electric field microenvironment-induced dynamic spatial confinement to stabilize i+ toward high-mass-loading and stable Zinc–Iodine batteries}, volume = {64}, year = {2025}, }
• (2025). Vacancy-defect single-atom catalysts for tandem CO2 electroreduction and carbonylation reactions from flue gas. ANGEW, 64(35), e202510693. (www)

  @article{ , abstract = {Tandem CO 2 reduction with carbonylation reactions represents a promising approach to convert greenhouse gases into valuable chemicals. Herein, we propose a universal “N/O mixed pre-coordination pyrolysis” strategy to construct vacancy-defect single atom catalysts (Ni 1 -, Mn 1 -, Fe 1 -, Co 1 -, and Cu 1 -NC) with M-N 3 coordination microenvironment. This vacancy-defect endows Ni 1 -NC with excellent performance for CO 2 electroreduction, achieving a CO faradaic efficiency exceeding 90% across a wide range of current densities up to 300 mA cm −2 . The generated CO was directly fed to carbonylation reactions, producing organic chemicals with yields of up to 91.7% and leading to produce 1.13 g of benzophenone in a single run. For the first time, the membrane separation CO 2 system was integrated with tandem catalytic system, enabling direct utilization of flue gas for benzophenone synthesis with a 76.6% yield. This work offers a sustainable, eco-friendly method for CO 2 separation and utilization by feeding industrial waste gas to carbonylation reactions.}, archive = {J_ANGEW}, author = {Qiu-Ping Zhao and Wen-Xiong Shi and Bo Wang and Zuo-Shu Sun and Shuang Yao and Tong-Bu Lu and Zhi-Ming Zhang}, doi = {10.1002/anie.202510693}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510693}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vacancy-defect single-atom catalysts for tandem CO2 electroreduction and carbonylation reactions from flue gas}, volume = {64}, year = {2025}, }
• (2025). Catalyst-engineered proton transfer pathways for selective hydrogen peroxide electrosynthesis in solid-state electrolytes. ANGEW, 64(35), e202510645. (www)

  @article{ , abstract = {Polymer-based solid electrolyte (SE) cells promise electrochemical synthesis of pure hydrogen peroxide (H 2 O 2 ), yet the protonation mechanisms governing the two-electron oxygen reduction reaction (2e − -ORR) remain unclear when using pure water as the proton source. Both Langmuir–Hinshelwood (LH, surface *H-mediated) and Eley–Rideal (ER, water-derived proton-coupled) pathways are theoretically plausible, but their practical dominance under SE conditions lacks experimental validation. Herein, we designed a hierarchical Ni─N 2 ─C─O single-atom/NiO nanocluster co-decorated porous carbon nanosheet catalyst (NiSA-NiO/pCNs) that achieved a Faradaic efficiency of 97% and a H 2 O 2 partial current density of 356 mA cm⁻ 2 (equivalent to 6.6 mmol cm −2 h −1 production rate) in a porous SE cell. Analysis of reaction intermediates and the local pH using in situ Raman spectroscopy, kinetic isotope effect, and density functional theory simulations showed the critical role of NiO nanoclusters in tuning the protonation pathway: NiO activates the ER mechanism via fast proton transfer from water dissociation, whereas NiSA/pCNs without NiO preferentially follow the LH mechanism through surface-adsorbed *H intermediates from interfacial transferred proton. These findings establish a catalyst design principle for proton transfer control in solid-state H 2 O 2 electrosynthesis.}, archive = {J_ANGEW}, author = {Jun Wang and Junheng Huang and Chunguang Jia and Wenxing Chen and Junxiang Chen and Shengjian Lin and Yangjie Liu and Kai Chen and Yiqi Liang and Suqin Ci and Zhenhai Wen}, doi = {10.1002/anie.202510645}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalyst-engineered proton transfer pathways for selective hydrogen peroxide electrosynthesis in solid-state electrolytes}, volume = {64}, year = {2025}, }
• (2025). Tandem-activatable PROTAC prodrug for tumor biomarker-driven near-infrared opto-proteolysis. ANGEW, 64(35), e202510641. (www)

  @article{ , abstract = {Tumor-specific protein degradation is crucial for successful cancer treatment by proteolysis-targeting chimera (PROTAC), which however still remains challenging. Here, we report a tandem-activatable PROTAC prodrug (TAP) strategy for precise on-tumor proteolysis in vivo. TAP is constructed by caging PROTAC with a tumor-homing cyclopeptide through a tandem-locking linker, which comprises a singlet-oxygen ( 1 O 2 ) cleavable moiety, a near-infrared (NIR) photosensitizer (PS) and a Cathepsin B (CatB)-cleavable dipeptide substrate. The proteolytic activity of TAP is initially turned off but can be sequentially switched on by tumor biomarker enzyme CatB and NIR light. Such a tandem-lock design ensures that PROTAC exclusively degrade oncoprotein target in tumor. The results revealed that TAP carried out a tumor-selective degradation of bromodomain-containing protein 4 (BRD4) under the cooperative action by CatB and NIR light, which further synergized with photodynamic therapy (PDT) by the PS to suppress tumor growth. This work thus presents the first tandem-activatable approach for spatiotemporally controlled proteolysis to minimize the off-tumor toxicity of PROTAC.}, archive = {J_ANGEW}, author = {Xiaoyan Lu and Xiaoning Wang and Hanwen Liao and Baitong Sha and Yan Zhang and Jinbo Li}, doi = {10.1002/anie.202510641}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem-activatable PROTAC prodrug for tumor biomarker-driven near-infrared opto-proteolysis}, volume = {64}, year = {2025}, }
• (2025). Twelvefold dearomative esterification of (6,6)Carbon nanobelt. ANGEW, 64(35), e202510544. (www)

  @article{ , abstract = {Carbon nanobelts (CNBs), cyclic aromatic hydrocarbons with belt-shaped topologies, have growing interest as structurally unique and optoelectronically promising nanocarbons. Yet, strategies for their direct and site-selective functionalization remain scarce. Here, we report a magnesium-mediated, multifold dearomative esterification of (6,6)CNB, enabling the installation of twelve ester groups in a single transformation. Single-crystal X-ray structural analysis revealed regioselective dearomatization patterns, whereas mechanistic studies uncovered a radical-driven pathway involving oxyiminium intermediate generated in situ from alkyl chloroformates and amide solvents. Computational analysis further indicated that strain release in the CNB framework drives the high degree of functionalization. This methodology not only expands the synthetic toolbox for aromatic nanobelts but also allows tunable modulation of their host–guest properties via enhanced conformational flexibility.}, archive = {J_ANGEW}, author = {Tsubasa Okumura and Daiki Imoto and Yuri Arachi and Akiko Yagi and Takehisa Maekawa and Kenichiro Itami}, doi = {10.1002/anie.202510544}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510544}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Twelvefold dearomative esterification of (6,6)Carbon nanobelt}, volume = {64}, year = {2025}, }
• (2025). A macrocycle-based supramolecular strategy for interchangeable screwdriver-like on-demand post-functionalization of covalent organic framework. ANGEW, 64(35), e202510534. (www)

  @article{ , abstract = {Constructing functionalized covalent organic frameworks (COFs) through post-functionalization constitutes one of the most important approaches to applications, but is frequently plagued by limited reaction types, tedious synthesis of different precursors, and time-consuming screening of synthetic parameters for COFs. Moreover, their functions are difficult to change once the functionalities are covalently attached to COF skeletons. Herein, we report a macrocycle-based supramolecular strategy for variable noncovalent post-functionalization on the same COF platform like an interchangeable screwdriver. As a proof of concept, pillar[5]arene (P5A) with electron-rich cavity is incorporated into COF as macrocycle host to anchor different electron-deficient guests of various functions. Such a design allows tunable post-functionalization of COF through host–guest interactions for customized utilities, which has been demonstrated by using a series of guests including organic salts for iodine capture and cyano-based ligands for metal ion separation. Removing the guests enables recycling of COF, consecutive reinstallation of different guests, and continuous use for implementing expected tasks. This work establishes a general noncovalent approach to on-demand interchangeable post-functionalization of COFs.}, archive = {J_ANGEW}, author = {Liancheng Hu and Yimin Cai and Xuwen Guo and Li Wang and Yongjie Jiang and Xiaowei Li and Ning Liu and Wen Feng and Lihua Yuan}, doi = {10.1002/anie.202510534}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510534}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A macrocycle-based supramolecular strategy for interchangeable screwdriver-like on-demand post-functionalization of covalent organic framework}, volume = {64}, year = {2025}, }
• (2025). Ultrathin PtSe2 nanowires in single-walled carbon nanotubes for hydrogen evolution reaction. ANGEW, 64(35), e202510463. (www)

  @article{ , abstract = {Platinum selenide (PtSe 2 ) has shown great potential for application in electrocatalysis. One-dimensional (1D) nanostructures are particularly advantageous for enhancing catalytic performance, as they expose abundant active sites at the edges and enable rapid charge transport. However, the synthesis of 1D PtSe 2 nanostructures for efficient electrocatalysis remains a challenge. Here, we report the controllable synthesis of ultrathin (0.4–2.0 nm) PtSe 2 nanowires (NWs) using single-walled carbon nanotubes (SWCNTs) as a confined template via direct selenization by chemical vapor deposition (CVD). The atom-resolved electron microscope combined with spectroscopy and theoretical calculations revealed that PtSe 2 NWs grow anisotropically along the <110> direction inside the SWCNTs, possessing zigzag edges and higher thermodynamical stability. Owing to the rich-edges with abundant unsaturated Pt atoms, the as-prepared PtSe 2 NWs exhibit excellent hydrogen evolution reaction (HER) activity at an extremely low Pt loading of 4.684 wt%, with an overpotential of 47 mV@10 mA cm −2 and a Tafel slope of 41.7 mV dec −1 . This work provides a novel strategy for synthesizing 1D ultrathin NWs and offers the potential to achieve low-cost and efficient Pt-based catalysts in the future.}, archive = {J_ANGEW}, author = {Nan Si and Rui Wang and Xianyu Hu and Yide Chang and Qingyuan He and Yang Wang and Yakui Mu and Yanming Wang and Siyu Liu and Qinglin Yuan}, doi = {10.1002/anie.202510463}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510463}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrathin PtSe2 nanowires in single-walled carbon nanotubes for hydrogen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). A multivalent targeting strategy for developing reactive oxygen species-activated tumor-seeking probe to guide precise surgical resection. ANGEW, 64(35), e202510441. (www)

  @article{ , abstract = {Optical molecular imaging with near-infrared (NIR) dyes provides a promising strategy for the visual detection of tumor tissues. However, conventional molecular probes often suffer from poor targeting specificity and low signal contrast during tumor detection. In this work, we developed a reactive oxygen species (ROS)-activated tumor-seeking probe (termed MB-PEG-Bio2 ) based on a multivalent biotin-targeting strategy. A bivalent biotin-targeting ligand was bonded to an ROS-responsive molecular scaffold to maximize receptor–ligand interactions, resulting in significantly stronger tumor affinity and selectivity of the probe. The optical signal of the proposed probe was initially masked and could be selectively activated by overexpressed ROS levels in the tumor microenvironment. This activation led to the specific release of the clinical dye methylene blue (MB), offering high-contrast NIR fluorescence and photoacoustic imaging signals for precise tumor visualization. MB-PEG-Bio2 demonstrated strong tumor selectivity, enabling the detection of tumors in different mice models, including accurate identification of small tumors (∼3 mm). Consequently, the probe could delineate tumor boundaries during fluorescence-guided surgery, significantly reducing postoperative tumor recurrence.}, archive = {J_ANGEW}, author = {Feiyang Liu and Lingyan Liu and Mengfan Zhang and Jinzi Li and Mingxin Li and Peng Wei and Tao Yi}, doi = {10.1002/anie.202510441}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510441}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A multivalent targeting strategy for developing reactive oxygen species-activated tumor-seeking probe to guide precise surgical resection}, volume = {64}, year = {2025}, }
• (2025). Enhanced active hydrogen absorption and stabilized Cu(I) species over cu-O-ce bridges boosting electrocatalytic CO2 reduction to ethylene. ANGEW, 64(35), e202510383. (www)

  @article{ , abstract = {Rational design of water activation center to promote active hydrogen (*H) generation and stabilize Cu(I) species are significant for the formation of multicarbon (C 2+ ) products over Cu-based catalysts in electrocatalytic CO 2 reduction reaction (CO 2 RR). Herein, CeO 2 nanograins and CuO nanothorns were selectively deposited on the edges of Cu 2 O cubes through the seed-mediated growth method. The as-synthesized Cu x O–CeO 2 composites exhibit enhanced Faradaic efficiency and partial current density of C 2 H 4 compared with Cu 2 O cubes. In situ spectroscopies and theoretical calculations confirm that the Cu–O–Ce bridges in Cu x O–CeO 2 composite can effectively enhance *H absorption and stabilize Cu(I) species, facilitating subsequent C–C coupling and further protonation into the key *COCHO intermediate of C 2 H 4 . This work provides new insights into modulating *H absorption and stabilizing Cu(I) species for boosting CO 2 to C 2+ products.}, archive = {J_ANGEW}, author = {Zhenwei Zhao and Yu Zhang and Junjun Li and Bingqing Yao and Hui Zhang and Zhicheng Zhang}, doi = {10.1002/anie.202510383}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced active hydrogen absorption and stabilized Cu(I) species over cu-O-ce bridges boosting electrocatalytic CO2 reduction to ethylene}, volume = {64}, year = {2025}, }
• (2025). Chiral cryptographic key-based fluorescence encryption enabled by stimuli-responsive Metal–Organic frameworks. ANGEW, 64(35), e202510219. (www)

  @article{ , abstract = {Increasing threats of data forgery breaches necessitate the development of advanced encryption strategies beyond traditional cryptographic methods. Fluorescence encryption has emerged as a promising alternative, yet current systems suffer from low security due to simple, reversible stimuli responses. Here, we introduce a novel lock-and-key encryption system using a chiral cyclodextrin metal–organic framework (CDMOF), termed Zole@CDMOF (Zole = acetylated benzoimidazole), for enantioselective discrimination of phenylethylamine (PEA) enantiomers.Confined Zole serves as the lock, while PEA enantiomers act as the key, selectively triggering fluorescence turn-on via acetyl─O bond cleavage and restoring excited-state intramolecular proton transfer (ESIPT) of deacetylated Zole. Mechanistic studies reveal that enantioselectivity arises from thermodynamic differences and distinct hydrogen-bonding interactions between PEA enantiomers. To enhance practical application, Zole@CDMOF is fabricated into a flexible sensor via scotch tape strategy, enabling visual indexing of enantiomeric excess. Additionally, we propose a barcode chiral encryption model, establishing a quadruply encrypted system with ultra-high security—allowing only one out of approximately two million keys to decrypt. This study pioneers the first chiral cryptographic key in fluorescence encryption, paving the way for ultra-secure encryption, advanced chiral sensing, and stimuli-responsive materials.}, archive = {J_ANGEW}, author = {Han Xie and Wei-Qi Wang and Yan Liu and Hao Han and Rong Shao and Zhao-Jin Wang and Xiu-Li Yang and Ming-Hua Xie and Yong Cui}, doi = {10.1002/anie.202510219}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510219}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral cryptographic key-based fluorescence encryption enabled by stimuli-responsive Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Dynamically dual-center coupled synergistic catalysis for highly efficient oxygen reduction. ANGEW, 64(35), e202510188. (www)

  @article{ , abstract = {The oxygen reduction reaction (ORR) suffers from inherent kinetic limitations arising from the competitive adsorption behavior of *OOH intermediates and their divergent conversion pathways toward either the 4e⁻-dominant route or the 2e⁻-peroxide byproduct. Conventional single-component catalysts fundamentally lack temporal-spatial control to simultaneously accelerate O─O bond cleavage while suppressing *H 2 O 2 desorption. To overcome this kinetic dilemma, herein, we propose a dynamically dual-center coupled synergistic (DCCS) catalytic mechanism enabled by precisely engineered PdRh─Pt nanosheet binary-component interfaces. Multidimensional in situ synchrotron radiation spectroscopy and theoretical studies reveal that the activated 4e⁻ pathway primarily occurs at PdRh sites. Additionally, Pt centers selectively reduce *OOH to *O and *H 2 O 2 , whereas neighboring PdRh sites facilitate ultrafast *H 2 O 2 migration and dissociation, effectively complementing the 4e⁻-dominant pathway. Hence, the DCCS catalysis redirects traditionally divergent product pathways toward a singular target product. This interfacial kinetic synergy achieves ultrahigh 4e⁻ kinetics, demonstrated by a six-fold increase of turnover frequency compared to that of commercial Pt/C. Moreover, the derived rechargeable Zn‒air batteries demonstrate exceptional stability over 200 h, establishing a new design principle for breaking kinetics trade-offs in heterogeneous catalysis through molecularly scheduling reaction pathways.}, archive = {J_ANGEW}, author = {Jingjing Jiang and Jiulong Wu and Chenyu Yang and Shuowen Bo and Jing Zhang and Baojie Li and Yuhao Zhang and Qizheng An and Xin Chen and Qinghua Liu and Wanlin Zhou}, doi = {10.1002/anie.202510188}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamically dual-center coupled synergistic catalysis for highly efficient oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). Strain-release driven arsenium ion bond insertion. ANGEW, 64(35), e202510186. (www)

  @article{ , abstract = {Although it marks a cornerstone of pnictogenium ion [R 2 Pn] + reactivity, the insertion of arsenium ions [R 2 As] + into non-polar bonds remains highly challenging. Herein, a synthetic approach is developed, which circumvents the limitations of insertion reactivity of [R 2 As] + (e.g., formal redox state of +V at As) via alleviation of ring strain in the substrate. Thus, unlocking arsenium ion bond insertion delivers the ring-expanded complexes [{L n M}(η 3 -Pn 3 AsCy 2 ][TEF] ({L n M} = Cp ‴ Ni, Pn = P ( 1 ); {L n M} = {CpMo(CO) 2 }, Pn = P ( 2 ), As ( 5 ); Cp ‴ = 1,2,4- t Bu 3 C 5 H 2 , [TEF] − = [Al{OC(CF 3 ) 3 } 4 ] − ). Computational analysis of the reaction mechanism and quantum crystallographic investigation of 1 highlight the release of ring strain as the crucial driving force for this reactivity. This rational is corroborated by the isolation of the arsenium ion coordinated [{CpMo(CO) 2 } 2 (μ,η 2:2 -P 2 AsCy 2 )][TEF] ( 3 ) as well as the phosphenium ion inserted [{CpMo(CO) 2 }(η 3 -As 3 PPh 2 )][TEF] ( 4 ).}, archive = {J_ANGEW}, author = {Christoph Riesinger and Florian Meurer and Lisa Zimmermann and Luis Dütsch and Manfred Scheer}, doi = {10.1002/anie.202510186}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202510186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strain-release driven arsenium ion bond insertion}, volume = {64}, year = {2025}, }
• (2025). Selective electrochemical production of ethylene from bicarbonate solution. ANGEW, 64(35), e202509975. (www)

  @article{ , abstract = {Carbon dioxide (CO 2 ) electroreduction directly from a reactive carbon solution (e.g., (bi)carbonate) provides a promising approach for integrating CO 2 capture and conversion. Compared to CO 2 conversion in gas-fed systems, this system typically suffers from low Faradaic efficiency (FE), especially for multicarbon (C 2+ ) products. Here, we report an engineered material structuring to selectively produce C 2+ products directly from a N 2 -saturated bicarbonate solution. Multiphysics modeling studies reveal the critical role of local current density distribution and the spatio-selective evolution of C 2+ products, which is favored in thinner catalysts (240 µm thickness). By jointly tailoring catalyst configuration and mass transport in bicarbonate electroreduction, adjusting the thickness, porosity, and surface oxidation of copper (Cu) mesh catalysts, as well as catholyte composition, we achieved a maximum C 2 H 4 FE of 39% and total C 2+ FE over 55% at 150 mA cm −2 with a 240 µm thick Cu mesh. The system is also stable for over 160 h at 100 mA cm −2 with maintained C 2 H 4 FE over 20%. Our electrolysis system converts bicarbonate to C 2+ with over 90% CO 2 utilization efficiency, reducing regeneration and separation costs. Optimizing catalyst pore structure, and copper surface oxide is a key to maximizing C 2 H 4 production from bicarbonate solutions.}, archive = {J_ANGEW}, author = {Behnam Nourmohammadi Khiarak and Gelson T. S. T. da Silva and Jackson Crane and Colin P. O'Brien and Michael R. Pepe and Christine M. Gabardo and Viktoria Golovanova and F. Pelayo García de Arquer and Cao-Thang Dinh}, doi = {10.1002/anie.202509975}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509975}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective electrochemical production of ethylene from bicarbonate solution}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed sila-cycloaddition of dichlorodisilanes: Selective Si─Cl activation for cyclic disilanes and enantioenriched synthesis. ANGEW, 64(35), e202509961. (www)

  @article{ , abstract = {Disilanyl architectures holds significant value across diverse fields, particularly in the development of advanced materials. However, their limited accessibility has hindered broader exploration. Herein, we report a catalytic strategy for the synthesis of structurally diverse cyclic disilanes through a [4 + 2] sila-cycloaddition between readily available dichlorodisilanes and 1,3-dienes. This transformation proceeds under mild, reductive nickel catalysis via an unusual Si─Cl bond activation pathway and accommodates a broad range of dienes, including bulk feedstocks, cyclic, multi-substituted, aliphatic, aromatic dienes, and trienes. An asymmetric variant further enables the efficient construction of chiral disilane frameworks with high enantioselectivity. The resulting disilacarbocycle adopts boat-like conformations, as revealed by X-ray analysis, due to the elongated Si─Si and Si─C bonds. Mechanistic studies suggest that a triplet Ni 0 species engages in an S N 2-type oxidative addition to the Si─Cl bond, favoring this pathway over a concerted Si─Si activation. The resulting Si─Ni(I) intermediates are energetically preferred over Si─Ni(II) analogs in the subsequent diene insertion step.}, archive = {J_ANGEW}, author = {Liangliang Qi and Shaojie Xu and Xiaobo Pang and Yu-Ke Wu and Xiaotai Wang and Xing-Zhong Shu}, doi = {10.1002/anie.202509961}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509961}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed sila-cycloaddition of dichlorodisilanes: Selective Si─Cl activation for cyclic disilanes and enantioenriched synthesis}, volume = {64}, year = {2025}, }
• (2025). Entire near-infrared-I electrochemiluminescence enhancement of gold nanoclusters. ANGEW, 64(35), e202509884. (www)

  @article{ , abstract = {Herein, entire near-infrared-I (NIR-I) electrochemiluminescence (ECL) enhancement of gold nanoclusters (Au NCs) is achieved by continuously regulating the plasmon resonance absorption wavelength of gold nanorods (Au NRs) to precisely match ECL emission wavelength of Au NCs (abbreviated as Au NCs/Au NRs), which challenges the drawbacks of traditional single wavelength ECL enhancement strategy. Interestingly, within the range of 670–820 nm, the ECL intensity of Au NCs/Au NRs is 3–4 times higher than that of individual Au NCs due to the acceleration of electron-hole recombination and radiation transition rate through high energy electromagnetic field. As a proof of concept, the Au NCs/Au NRs with the ECL emission of 670 nm is employed as high-efficiency ECL emitter to achieve high-resolution ECL image and construct biosensor for realizing ultrasensitive detection of matrix metalloproteinase-2 (MMP-2) related to liver failure. Significantly, the proposed ECL enhancement strategy effectively enhances the ECL emission of metal nanoclusters (M NCs) over a wide wavelength range and advances a new path for other tunable nanomaterials to enhance the ECL emission of M NCs, which is expected to be applied to in the field of multispectral ECL imaging, multimodal optoelectronic devices, and spectrum-resolved multiplexed biosensing systems.}, archive = {J_ANGEW}, author = {Zhao-Chen Shen and Yi-Fei Chen and Ya-Qin Chai and Jia-Li Liu and Ruo Yuan}, doi = {10.1002/anie.202509884}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509884}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Entire near-infrared-I electrochemiluminescence enhancement of gold nanoclusters}, volume = {64}, year = {2025}, }
• (2025). Reduction of CO2 accompanying ATP synthesis in polydopamine microreactors covered by lipid bilayers with ATPase. ANGEW, 64(35), e202509835. (www)

  @article{ , abstract = {Global energy and environmental crises have stimulated increased efforts toward converting CO 2 into valuable chemicals or energy substance. Inspired by natural chloroplasts and mitochondria, we build an innovative polydopamine-armored multiple enzyme microreactor for co-immobilizing glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 3-phosphoglyceric phosphokinase (PGK), formate dehydrogenase (FDH), and ATPase-incorporating proteoliposome, providing spatially confined microenvironments akin to natural systems. Within this microreactor, GAPDH and PGK catalyze the conversion of glyceraldehyde 3-phosphate to 3-phosphoglyceric acid, reducing β-nicotinamide adenine dinucleotide (NAD + ) to NADH and generating a proton influx that drives ATP synthesis. The microreactor possesses strong affinity for CO 2 , combined with FDH, facilitates the reduction of CO 2 to formic acid, oxidizing NADH back to NAD + and enabling the recycling of the NAD + /NADH redox couple. This process further boosts ATP production by contributing additional protons. Such microreactor adeptly orchestrates the chloroplast's enzymes to fix CO 2 and the mitochondrion's enzymes to synthesize ATP into a unified artificial biomimetic system, effectively replicating the glycolysis process to simultaneously achieve CO 2 fixation, NADH regeneration, and ATP synthesis. This strategy not only holds great potential to inspire significant design innovations for more efficient ATP synthesis from low-value substances but also greatly expands the application scenarios for biomolecular motors.}, archive = {J_ANGEW}, author = {Yang Xu and Fanchen Yu and Yi Jia and Xuanze Meng and Rong Shu and Hong Li and Zibo Li and Junbai Li}, doi = {10.1002/anie.202509835}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509835}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reduction of CO2 accompanying ATP synthesis in polydopamine microreactors covered by lipid bilayers with ATPase}, volume = {64}, year = {2025}, }
• (2025). Selection of ribofuranose-isomer among pentoses by phosphorylation with diamidophosphate. ANGEW, 64(35), e202509810. (www)

  @article{ , abstract = {The unique structure–function relationship of the ribofuranose ring in RNA has inspired various chemical pathways to select for the ribofuranose form (over the ribopyranose form), especially in a prebiotic context. Herein we show that the reaction of diamidophosphate (DAP) with the four pentoses—ribose, arabinose, xylose, and lyxose—naturally selects the ribofuranose form more efficiently when compared to the other three pentoses. All four pentoses form the initial diamidophosphate-adduct; however, ribose undergoes rapid conversion to ribofuranose-1,2- and 2,3-cyclicphosphate products, while the other three pentoses show significant accumulation of the initially formed DAP-adducts and slow conversion to the cyclicphosphate products. Arabinose and xylose show a distribution between furanose- and pyranose-1,2-cyclicphosphate products, while lyxose forms the furanose-1,2- and pyranose-2,3-cyclicphosphate products. This trend is also manifested when starting from a mixture of pentoses where ribofuranose 1,2-amidocyclicphosphate dominates the product distribution. Such selection for ribofuranose among pentoses by phosphorylation i) provides another venue of how a ribofuranose structure can selectively emerge through abiotic chemical reaction suitable for elaboration toward RNA and ii) adds to the body of experimental work addressing the chemical origin of RNA.}, archive = {J_ANGEW}, author = {Harold A. Cruz and Ramanarayanan Krishnamurthy}, doi = {10.1002/anie.202509810}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509810}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selection of ribofuranose-isomer among pentoses by phosphorylation with diamidophosphate}, volume = {64}, year = {2025}, }
• (2025). A bifunctional organic photocatalyst for efficient single-electron and energy transfer activation. ANGEW, 64(35), e202509770. (www)

  @article{ , abstract = {Bifunctional photocatalysts capable of mediating both single-electron transfer (SET) and energy transfer (EnT) processes are rare and typically metal based. Here, we present 3-thioaryl-4-hydroxycoumarins, a new family of cost-effective organic photocatalysts that leverage a stabilized charge-transfer (CT) excited state to achieve both strong reducing power and efficient energy transfer. The spatial separation of the HOMO and LUMO stabilizes the CT state, enhancing SET reactivity ( E * red = −3.08 V vs. SCE) while maintaining a sufficiently high triplet energy ( E T = 67 kcal mol −1 ) for EnT-driven transformations. This dual reactivity enables the activation of redox-inert substrates ( E red < −2.8 V vs. SCE) via SET reduction, generating radicals suitable for diverse C─S, C-─P, C─B, and C─C bond-forming transformations, alongside EnT-based processes such as E / Z olefin isomerization and [2 + 2] photocycloadditions. Mechanistic studies, supported by photophysical and theoretical analyses, confirmed the catalyst's bifunctionality.}, archive = {J_ANGEW}, author = {Sumitava Mallik and Hailong Wang and Nunzio Matera and Bi-Xiao Li and Stefano Stagni and Paolo Melchiorre}, doi = {10.1002/anie.202509770}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509770}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bifunctional organic photocatalyst for efficient single-electron and energy transfer activation}, volume = {64}, year = {2025}, }
• (2025). Porous organic cages as building blocks for framework materials. ANGEW, 64(35), e202509618. (www)

  @article{ , abstract = {Confined nanospaces play a fundamental role in nature, inspiring synthetic analogues that emulate biological precision and efficiency. Among these, porous crystalline materials such as covalent organic frameworks (COFs), metal-organic frameworks (MOFs), and molecular cage compounds have emerged as powerful platforms for catalysis, separation, and energy storage. Recent developments highlight the potential of porous organic cages (POCs) as modular building blocks for the construction of advanced materials. In this Minireview, their integration into extended frameworks, such as Cage-COFs and Cage-MOFs, is described, as they allow precise control over porosity and enhance chemical robustness. These hybrids merge the structural regularity of COFs with the discrete functionality of cages, enabling the design of lightweight, hierarchically organised materials. In addition, cage-containing polymers and supramolecular frameworks are discussed. Collectively, these developments position POCs as versatile synthons for next-generation porous materials, unlocking pathways toward functional, adaptive, and recyclable architectures.}, archive = {J_ANGEW}, author = {Marcos Martínez-Fernández and Yannic Hartmann and Bernd M. Schmidt}, doi = {10.1002/anie.202509618}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porous organic cages as building blocks for framework materials}, volume = {64}, year = {2025}, }
• (2025). Solution-processed amorphous zero-dimensional organic metal halide hybrid films for direct X-ray detectors. ANGEW, 64(35), e202509589. (www)

  @article{ , abstract = {Zero-dimensional (0D) organic metal halide hybrids (OMHHs) are emerging materials with significant potential for optoelectronic applications, including direct X-ray detectors. While 0D OMHH single crystals exhibit excellent X-ray detection properties, their scalability remains a significant challenge due to the time-intensive growth process and difficulty in producing large single crystals exceeding a few centimeters. This limitation hinders their practicality for large-area detector applications. Here, we report for the first time the development of amorphous 0D OMHH films via solution processing for efficient direct X-ray detection. By reacting a non-crystalline organic halide, triphenyl(9-phenyl-9H-carbazol-3-yl)phosphonium bromide (TPPCarzBr), with zinc bromide (ZnBr 2 ), we have successfully produced amorphous 0D (TPPCarz) 2 ZnBr 4 films with controlled thickness via facile solution processing. The organic cations (TPPCarz⁺) feature a lower bandgap than the ZnBr 4 2− anions, enabling efficient molecular sensitization, where ZnBr 4 2− anions serve as X-ray absorbers and TPPCarz⁺ cations as charge transporters. Direct X-ray detectors based on 0D (TPPCarz) 2 ZnBr 4 films demonstrate outstanding performance, achieving a stable X-ray detection sensitivity of 2,165 µC Gy air ⁻ 1 cm⁻ 2 at 20 V mm⁻¹ and a detection limit of 6.01 nGy air s⁻¹. The amorphous nature of these films enhances their processability, allowing for fabrication in various sizes and shapes, and making them highly adaptable for scalable detector applications.}, archive = {J_ANGEW}, author = {Oluwadara J Olasupo and Abiodun M. Adewolu and Mohammad Khizr and Tarannuma F. Manny and He Liu and Tunde B. Shonde and Md S. Islam and Sahel Moslemi and Ethan Kim and J.S. Raaj V Winfred and Thilina N.D.D. Gamaralalage and Yan-Yan Hu and Ranjan Das and Biwu Ma}, doi = {10.1002/anie.202509589}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solution-processed amorphous zero-dimensional organic metal halide hybrid films for direct X-ray detectors}, volume = {64}, year = {2025}, }
• (2025). Long-range electronically polarized fe-n5 catalysts redirect polymerization-driven phenolic pollutant removal toward sustainable carbon sequestration. ANGEW, 64(35), e202509493. (www)

  @article{ , abstract = {A sustainable strategy for simultaneous pollutant removal and carbon sequestration is offered by the peroxymonosulfate (PMS)-mediated electron transfer mechanism. However, it remains challenging to achieve catalysts with durable and high activity. A novel catalyst design strategy leveraging boron doping that induces long-range electronic polarization to precisely modulate PMS complexation dynamics on single-atom catalysts (SACs) is proposed in this study. It is demonstrated that B-doping induces asymmetric Fe-N 5 coordination at the atomic iron centers (Fe SA -BNC) while creating electron-enriched carbon auxiliary sites. The electron distribution is synergistically optimized by this dual-site configuration through lowering the d-band center and establishing a polarized charge transfer pathway. Complexes with enhanced oxidation potential are generated by the engineered Fe SA -BNC/PMS, redirecting bisphenol A degradation from conventional radical-mediated mineralization to an interfacial polymerization pathway via outer-sphere electron transfer. Remarkably, >3 times higher total organic carbon (TOC) removal activity compared to state-of-the-art catalysts and 4 orders of magnitude higher reactivity than conventional carbon nitride (CN) catalyst are exhibited by the optimized catalyst. Excellent operational stability (>1700 h continuous operation) with >120 L actual wastewater treatment capacity is demonstrated by practical implementation in a continuous-flow microreactor. This work advances electronic modulation strategies for sustainable water purification technologies.}, archive = {J_ANGEW}, author = {Yanchun Deng and Yingtang Zhou and Zilong Song and Xin Yang}, doi = {10.1002/anie.202509493}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Long-range electronically polarized fe-n5 catalysts redirect polymerization-driven phenolic pollutant removal toward sustainable carbon sequestration}, volume = {64}, year = {2025}, }
• (2025). Structural differentiation of homologous anisodimensional frameworks driven by site-selective polymerization. ANGEW, 64(35), e202509415. (www)

  @article{ , abstract = {Theoretically, distinguished from the dimensional isomers in reticular chemistry, structures with different dimensions can also be formed by site-selective polymerization using identical building blocks bearing a high density of reactive sites. Unfortunately, the spatial confinement imposes significant challenges for molecular building blocks to achieve dimensional differentiation via their intrinsic site-selective reactivity. In this work, we first report the dimensional differentiation of covalent organic frameworks (COFs) driven by site-selective polymerization of identical molecular building blocks with a high density of reactive sites. This unique phenomenon was demonstrated for the first time to originate from the role of aniline in enhancing the reversibility of the reaction system and modulating the conformational flexibility of the monomers. We systematically elucidated the mechanism underlying this dimensional differentiation and successfully demonstrated the generality of the synthetic strategy. Moreover, the residual benzaldehyde in the frameworks generated via the site-selective polymerization of the building blocks can serve as exciton acceptors, significantly enhancing the photocatalytic performance. This work not only offers a novel strategy for regulating the dimensionality of COFs but also provides a valuable reference for precisely controlling the conformational flexibility of building blocks to enable topological transformations.}, archive = {J_ANGEW}, author = {Pan He and Dongyu Li and Pengyu Yan and Jinchun Zhou and Kaifu Yu and Kecheng Cao and Yang Li and Lijian Ma}, doi = {10.1002/anie.202509415}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509415}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural differentiation of homologous anisodimensional frameworks driven by site-selective polymerization}, volume = {64}, year = {2025}, }
• (2025). Optimizing bromine complexation and kinetics: A bisimidazole strategy for high-performance zn-br static batteries. ANGEW, 64(35), e202509293. (www)

  @article{ , abstract = {Zinc–bromine (Zn–Br) static batteries are promising for large-scale energy storage, yet the practical application is hindered by the long-standing trade-off about bromine complexing agents (BCAs) between bromine complexation strength and redox kinetics. Herein, we report a rationally designed bisimidazolium salt, 1,4-bis(3-methylimidazolium-1-yl) butane dibromide ([bMImB]Br₂), which features a symmetric molecular structure that reconciles this contradiction. [bMImB]Br₂ demonstrates strong bromine affinity, stemming from its high atomic charge of N + and low solubility—properties comparable to those of tetraalkyl-quaternary ammonium salts. Simultaneously, it retains low steric hindrance typical of monoimidazole compounds, thereby enabling fast electrode kinetics. As a result, Zn–Br batteries incorporating [bMImB]Br₂ deliver a high specific energy of 116 Wh·kg⁻¹, alongside an average coulombic efficiency (CE) of 99.22% and energy efficiency (EE) of 89.35% at 10 mAh·cm⁻ 2 (0.5 C) for over 150 cycles. Furthermore, the flexible pouch cell maintains a discharge capacity of 110 mAh and 99.7% CE over 100 cycles, even under mechanical deformation. This work offers a generalizable molecular design strategy for developing next-generation BCAs in halogen-based energy storage systems.}, archive = {J_ANGEW}, author = {Yunting Wu and Chen Xu and Chengjun Lei and Wenjiao Ma and Wei Zhang and Xin He and Xiao Liang}, doi = {10.1002/anie.202509293}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509293}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimizing bromine complexation and kinetics: A bisimidazole strategy for high-performance zn-br static batteries}, volume = {64}, year = {2025}, }
• (2025). Unlocking the power of lewis basicity in oxide lattice oxygens: A regulating force for enhanced oxygen evolution kinetics in li-o2 batteries. ANGEW, 64(35), e202509132. (www)

  @article{ , abstract = {Lithium-oxygen batteries (LOBs) require fast oxygen conversion kinetics to achieve good cycling performance and high energy efficiency. In the text of catalysts for LOBs, the Lewis basicity of lattice oxygens (O L ) in common transition metal oxides is often underestimated due to the weak electron donor characteristic of O L . In this work, a new spinel-type high entropy oxide with Lewis basicity (LB-HEO) was synthesized through a Joule-heating method. O L was activated by regulating the tetrahedral site-O L -octahedral site (M Td -O L -M Oh ) units in the spinel-type HEO, enhancing the LB. Used as a cathode catalyst for LOBs, LB-HEO could attract Li + and increase the disorder in discharge product, lithium peroxide (Li 2 O 2 ), promoting the delithiation process and the interfacial charge transfer at the LB-HEO|Li 2 O 2 interface. The activation energy of interfacial charge transfer was significantly reduced from 63.5 to 22.4 kJ mol −1 . As a result, a low charging overpotential of 0.97 V and a long cycling lifespan of 135 cycles at 100 mA g −1 were achieved with a capacity limitation of 1000 mAh g −1 . The strategy based on the regulation of Li + behavior through its interaction with Lewis bases provides a promising prospect for the design of non-noble metal catalysts for high-performance LOBs.}, archive = {J_ANGEW}, author = {Hao-Min Guan and Zhi-Peng Cai and Xue-Yan Wu and Kai-Xue Wang and Jie-Sheng Chen}, doi = {10.1002/anie.202509132}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509132}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking the power of lewis basicity in oxide lattice oxygens: A regulating force for enhanced oxygen evolution kinetics in li-o2 batteries}, volume = {64}, year = {2025}, }
• (2025). Solid-state NMR reveals reorganization of the aspergillus fumigatus cell wall due to a host-defence peptide. ANGEW, 64(35), e202509012. (www)

  @article{ , abstract = {The limited availability of antifungal drug treatments and the rising issue of drug resistance highlight the urgent need for new antifungal drugs to combat drug-resistant Aspergillus fumigatus . The host-defence peptide cathelicidin-2 has demonstrated a significant inhibitory effect on azole-resistant Aspergillus fumigatus but its mechanism of action remains elusive. We applied a tailored set 1 H and 13 C detected solid state nuclear magnetic resonance experiments to elucidate the cell wall composition of Aspergillus fumigatus and to shed light on the mechanism of action of the peptide within the cell wall. Our results revealed that presence of the peptide affects galactosaminogalactan, an important component involved in the pathogenesis of invasive aspergillosis, as well as other specific polysaccharides and amino acids within the mobile cell wall domain. At longer exposure times, the peptide also influences the rigid cell wall domains by enhancing water penetration into the hydrophobic rigid cell wall domain. The findings reveal how the peptide can reach the plasma membrane and may aid the design of novel antifungal drugs with enhanced efficacy.}, archive = {J_ANGEW}, author = {Ajit Kumar Bishoyi and Jacq van Neer and Salima Bahri and Sophie Lorenz and Hans de Cock and Marc Baldus}, doi = {10.1002/anie.202509012}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202509012}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solid-state NMR reveals reorganization of the aspergillus fumigatus cell wall due to a host-defence peptide}, volume = {64}, year = {2025}, }
• (2025). Light-driven ratchet mechanism accelerates regioselective metal-cation exchange in a heterobimetallic helicate. ANGEW, 64(35), e202508952. (www)

  @article{ , abstract = {Molecular machines rely on their capacity to exploit non-equilibrium processes to perform work. However, the development of these non-equilibrium processes, such as molecular ratchets, is still in its early stages. Here, we report a diazocine-containing ligand ( L ) harbouring two distinct chelating coordination sites that can self-sort into dinuclear homo- and heterobimetallic helicates ([Fe II 2 L ](OTf) 4 , [Co II 2 L ](OTf) 4 , [Zn II 2 L ](OTf) 4 , [Zn II Fe II L ](OTf) 4 , [Zn II Co II L ](OTf) 4 ) with precisely controlled metal cation distribution. The photoisomerisation of the helicates operates via a molecular ratchet mechanism, resulting in metastable diastereomers that shift the system from thermodynamic equilibrium. Continuous white-light irradiation autonomously drives this ratchet process, selectively enriching an out-of-equilibrium pseudo-mesocate structure. Crucially, the ratchet mechanism can significantly accelerate metal-cation exchange from the [Zn II 2 L ](OTf) 4 helicate to the [Zn II Fe II L ](OTf) 4 helicate. Thus, the system operates in a manner reminiscent of a “claw machine”, selectively seizing Fe II ions when subjected to a precisely controllable external stimulus. These findings lay the foundation for creating adaptive and reconfigurable supramolecular structures that use non-equilibrium phenomena on a molecular level.}, archive = {J_ANGEW}, author = {Maximilian J. Notheis and Gregor Schnakenburg and Larissa K. S. von Krbek}, doi = {10.1002/anie.202508952}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508952}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-driven ratchet mechanism accelerates regioselective metal-cation exchange in a heterobimetallic helicate}, volume = {64}, year = {2025}, }
• (2025). Near-infrared light catalysis of carbon dioxide reduction by conjugated porous aromatic frameworks. ANGEW, 64(35), e202508924. (www)

  @article{ , abstract = {Current CO 2 photocatalytic systems mainly work in ultraviolet (UV) and visible (Vis) light regions, and the inability to utilize the abundant near-infrared (NIR) radiation or the low utilization rate is still a bottleneck for practical applications. We address this challenge through the strategic synthesis of metal-free conjugated porous aromatic frameworks (PAFs), PAF-332-DCM, to enhance the NIR absorption capabilities, achieving a CO production rate of ~74.7 µmol g −1 h −1 in gas-solid phase CO 2 reduction, surpassing typical NIR-responsive catalysts. Meanwhile, PAF-332-DCM can obtain a CO production rate of 344.1 µmol g −1 h −1 in full-spectrum irradiated CO 2 reduction. Infrared thermography reveals that the non-radiative attenuation of PAF-332-DCM leads to high photothermal temperature under NIR irradiation, which accounts for its reduction performance. Mechanistic studies combining fs-TA spectroscopy and in situ infrared characterization elucidate the photocatalytic pathway and intermediate formation. This result indicates that PAF-332-DCM can be a promising metal-free catalyst for practical solar-driven CO 2 conversion.}, archive = {J_ANGEW}, author = {Zihao Wang and Chi Cao and Li Jiang and Zihao Xing and Jiangtao Jia and Guangshan Zhu}, doi = {10.1002/anie.202508924}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared light catalysis of carbon dioxide reduction by conjugated porous aromatic frameworks}, volume = {64}, year = {2025}, }
• (2025). Tuning encodable tetrazine chemistry for site-specific protein bioorthogonal ligations. ANGEW, 64(35), e202508922. (www)

  @article{ , abstract = {Using genetic code expansion (GCE) to encode bioorthogonal chemistry has emerged as a promising method for protein labeling, both in vitro and within cells. Here, we demonstrate that tetrazine (Tet) amino acids incorporated into proteins are highly tunable and have extraordinary potential for fast and quantitative bioorthogonal ligations. We describe the synthesis and characterization of reaction rates for 29 Tet amino acids (20 of which are new) and compare their encoding ability into proteins using evolved tRNA/RS pairs. For these systems, we characterized on-protein Tet stability, reaction rates, and ligation extents as the utility of a bioorthogonal labeling group depends on its stability and reactivity when encoded into proteins. By integrating data on encoding efficiency, selectivity, on-protein stability, and in-cell labeling for Tet tRNA/RS pairs, we developed the smallest, fastest, and most stable Tet to date. This was achieved by introducing fluorine substituents to Tet4, resulting in reaction rates at the 10⁶ M⁻¹s⁻¹ level while minimizing degradation. This study expands the toolbox of bioorthogonal reagents for Tet-sTCO-based, site-specific protein labeling and demonstrates that the Tet is a uniquely tunable, highly reactive, and encodable bioorthogonal functional group. These findings provide a foundation to further explore Tet encoding and reactivity.}, archive = {J_ANGEW}, author = {Subhashis Jana and Alex J. Eddins and Yogesh M. Gangarde and P. Andrew Karplus and Ryan A. Mehl}, doi = {10.1002/anie.202508922}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508922}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning encodable tetrazine chemistry for site-specific protein bioorthogonal ligations}, volume = {64}, year = {2025}, }
• (2025). Bicyclic selenenyl sulfides with tuned bioreductive step rates reveal constraints for probes targeting thioredoxin reductase. ANGEW, 64(35), e202508911. (www)

  @article{ , abstract = {The reductive activation of dichalcogenide probes by thiol-type oxidoreductases proceeds through a cascade of consecutive, partly reversible steps. Stereocontrol elements can modulate the reaction rates of these steps to reach substrate-controlled kinetic selectivity for reductase chemotypes in live cells. We now deploy regio-, diastereo-, template-, and pH-control elements to shape the reactivity of unprecedented bicyclic selenenyl sulfides ( SeSP ), arriving at probes that selectively target the mammalian selenoenzyme thioredoxin reductase TrxR1. We accessed these densely functionalised cis - or trans -fused 1,2-thiaselenanes on gram scale over 5 steps by using a regioselective key step that elaborates an unusual, differentially protected 2,2′-bis-aziridine intermediate through sequential one-pot chalcogen introduction and selenenyl sulfide formation. By profiling a set of regio- and diastereoisomeric bicycles for their partly or fully reversible reactivity during reductive activation, we show how effects that slow their reduction steps (addition then resolution) can compensate by vastly accelerating subsequent activation (cyclisation) speeds, such that cellular processing is effective and TrxR-selective. More broadly, this study shows how multistep cascade probes can leverage conformational effects and internal noncovalent interactions to differentiate step kinetics along their on-target versus off-target reaction pathways, thus achieving reaction-based target selectivity in complex biological settings.}, archive = {J_ANGEW}, author = {Lukas Zeisel and Lucas Dessen Weissenhorn and Karoline C. Scholzen and Andrea Madabeni and Laura Orian and Elias S. J. Arnér and Oliver Thorn-Seshold}, doi = {10.1002/anie.202508911}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508911}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bicyclic selenenyl sulfides with tuned bioreductive step rates reveal constraints for probes targeting thioredoxin reductase}, volume = {64}, year = {2025}, }
• (2025). NonCovalent aggregation-driven D-band engineering in nickel cocatalysts for efficient CO2 photoreduction. ANGEW, 64(35), e202508683. (www)

  @article{ , abstract = {Efficient CO 2 activation remains a pivotal challenge in photocatalytic CO 2 reduction, necessitating precise electronic modulation of catalytic centers to overcome kinetic limitations. In this work, we engineer Ni(bpy) 3 Br 2 cocatalyst aggregates via noncovalent self-assembly and systematically unravel the role of aggregation in governing photocatalytic performance. A synergistic combination of experimental and theoretical analyses demonstrates that symmetry disruption within the aggregates induces localized charge redistribution. Such a charge redistribution triggers a 0.6 eV upshift in the Ni d-band center, which delivers lower Gibbs free energies for the formation of *CO 2 and *COOH. The optimized aggregates achieve a record-high quantum yield of 26.84% at 450 nm with 99.3% CO selectivity, representing the highest performance reported to date for visible-light-driven CO 2 -to-CO conversion systems. Importantly, the d-band center of the Ni sites can be precisely modulated by varying the aggregation degree of Ni(bpy) 3 Br 2 . This work not only advances a novel d-band center modulation strategy for electronic configuration engineering but also provides in-depth atomic-level insights into the aggregation-induced symmetry-regulated d-band center.}, archive = {J_ANGEW}, author = {Chun Hao and Jie Wang and Hu Shi and Hongxia Zhang and Jianghong Zhao and Baoyue Cao and Pengju Yang}, doi = {10.1002/anie.202508683}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508683}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NonCovalent aggregation-driven D-band engineering in nickel cocatalysts for efficient CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Synthesis of a library of N-monofluoromethyl compounds from N-monofluoromethyl Carbamoyl/Thiocarbamoyl fluorides. ANGEW, 64(35), e202508594. (www)

  @article{ , abstract = {The distinctive chemical properties of fluorine atoms have enabled fluorine-containing compounds to make significant strides in the pharmaceutical and materials fields. However, due to the very limited synthetic methods, the enormous potential of N -monofluoromethyl compounds has not yet been unlocked. In this study, we present an operationally simple and practical protocol for various largely underexplored N -monofluoromethyl compounds, utilizing two powerful and isolable building blocks: N -CH 2 F thio carbamoyl fluorides and N -CH 2 F carbamoyl fluorides. Additionally, the reactivity of fluorine atoms located at different positions of the two building blocks toward nucleophilic substitution was investigated both experimentally and theoretically.}, archive = {J_ANGEW}, author = {Liye Ma and Lvqi Jiang and Guangsheng Tian and Zijian Lin and Zhongquan Lin and Yu Xu and Zihao Guo and Leibing Wang and Jie Liu and Wenbin Yi}, doi = {10.1002/anie.202508594}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508594}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of a library of N-monofluoromethyl compounds from N-monofluoromethyl Carbamoyl/Thiocarbamoyl fluorides}, volume = {64}, year = {2025}, }
• (2025). Boosting performance of quasi-solid-state zinc ion batteries via zincophilic solubilization. ANGEW, 64(35), e202508556. (www)

  @article{ , abstract = {Hydrogel electrolytes hold great promise in tackling severe issues facing aqueous zinc-ion batteries (AZIBs). However, to satisfy the quest of flexible and eco-friendly batteries, developing low-cost and high mechanical durability hydrogel electrolyte remains a challenge. Here, employing the zincophilic solubilizer urea, we break the classical concentration limits of the low-cost Zn(Ac) 2 salt and introduce it into the hydrogel skeleton. The “salting out” effect give the polymer chain sediments a tighter bundle and twist effect. The as-formed hydrogel electrolyte can endure 557% high elongation and 3.7 MPa compressive strength to resist repeated zinc plating/striping process and external physical stimuli. The in situ polyurea solid electrolyte interphase (SEI) layer leads to thermodynamically stable anode/electrolyte interface. Utilizing the hydrogel electrolyte, the zinc anode shows high reversibility, leading to an average Coulombic efficiency (CE) of 99.93% for 150 cycles on the Zn//Cu battery. When assembled with NH 4 V 4 O 10 cathode (NVO), the full battery delivers a high capacity of 253.8 mAh g −1 beyond 1000 cycles longevity at 1 A g −1 . The pouch battery also shows a high capacity of 280.7 mAh g −1 at 500 mA g −1 and operate steadily for 90.13% retention after 200 cycles, and maintained a stable voltage even experienced bending and folding.}, archive = {J_ANGEW}, author = {Yifan Wang and Weilin Yan and Xuejun Zhu and Jinghao Li and Zhaoqian Li and Hong Zhang and Yingke Ren and Lie Mo and Yang Huang and Lei Zhang and Linhua Hu}, doi = {10.1002/anie.202508556}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508556}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting performance of quasi-solid-state zinc ion batteries via zincophilic solubilization}, volume = {64}, year = {2025}, }
• (2025). Nuclear quantum confinement enables robust deuterium bonds for highly reversible aluminum anodes. ANGEW, 64(35), e202508422. (www)

  @article{ , abstract = {The hydrogen evolution reaction (HER) fundamentally limits aluminum electroreduction in aqueous electrolytes by dominating interfacial charge transfer. Here, we suppress HER by engineering deuterium bonds (D-bonds) through nuclear quantum effects, confining D between D₂O and DMF molecules. This quantum confinement weakens hydrogen delocalization and restructures the Al 3+ solvation sheath, reducing water activity kinetically and thermodynamically. The regulated electrolyte enables uniform aluminum nucleation and dense plating layers, achieving 569 h (0.05 mA cm −2 ) and 379 h (0.1 mA cm −2 ) cycling stability in the 2D 2 O/1DMF electrolyte, which outperforms traditional sulfate electrolytes by 3.6 and 6.1 times, respectively. Our work uniquely leverages nuclear quantum confinement to engineer robust D-bonds, simultaneously suppressing HER and enabling atomic-level control over aluminum ion solvation structures for unprecedented Al redox reversibility in sulfate electrolytes. This exemplification pushes the electrolyte engineering from extensive component adjustment to quantum precision engineering, which provides an innovative solution for the high-activity water-based battery system}, archive = {J_ANGEW}, author = {Hao Cheng and Yao Lu and Zheng Li and Zibo Chen and Chao Chen and Xinyi Li and Hailin Yu and Adham Hashibon and Zhongliang Tian and Guanjie He}, doi = {10.1002/anie.202508422}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508422}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nuclear quantum confinement enables robust deuterium bonds for highly reversible aluminum anodes}, volume = {64}, year = {2025}, }
• (2025). Lignin-derived polyanionic crosslinked gel interfacial layer with ion-sieving and ion-regulating capabilities for dendrite-free zinc anodes. ANGEW, 64(35), e202508359. (www)

  @article{ , abstract = {The severe side reactions and rampant dendrite growth on the zinc (Zn) electrode significantly hinder the practical applications of aqueous zinc-ion batteries (AZIBs). Herein, we fabricate a multifunctional interfacial layer composed of polyvinylidene difluoride (PVDF) and polyanionic gel featuring ion-sieving and ion-regulating capabilities that effectively protects the Zn anode. The abundant ─SO 3 − groups in the polyanionic gel optimize the Zn 2+ solvent sheath structure while simultaneously providing ion-sieving function, which significantly facilitates Zn 2+ migration. The lignin derivatives are pre-adsorbed onto the Zn anode surface, directing nucleation along the Zn (002) plane and offering electrostatic shielding effects to facilitate uniform Zn 2+ deposition. Additionally, the polyanionic gel inhibits water activity by forming strong hydrogen bonds with water, while the PVDF layer adjacent to Zn electrode significantly reduces water-induced side reactions. Consequently, the Zn electrodes incorporating this protective layer demonstrated stable and efficient deposition/stripping behaviors across a wide range of current densities. The Zn||NaV 3 O 8 ·1.5H 2 O full cells demonstrate remarkable cycling stability, maintaining the capacity of 176.1 mAh g −1 after 1000 cycles at 5 A g −1 and 101.2 mAh g −1 after 2500 cycles at 10 A g −1 . This innovative strategy presents a promising approach to the development of high-performance AZIBs.}, archive = {J_ANGEW}, author = {Wanting Zhou and Zetao Chen and Shunshun Zhao and Mengyu Liu and Shimou Chen}, doi = {10.1002/anie.202508359}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508359}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lignin-derived polyanionic crosslinked gel interfacial layer with ion-sieving and ion-regulating capabilities for dendrite-free zinc anodes}, volume = {64}, year = {2025}, }
• (2025). Single-molecule electrochemiluminescence imaging of plasmonic hot spot reactivity. ANGEW, 64(35), e202508266. (www)

  @article{ , abstract = {Localized surface plasmon resonance (LSPR), an important optical property of noble metal nanomaterials, is extensively applied in electrochemistry. However, the specific LSPR effects on metallic nanoparticles are difficult to unravel and evaluate, owing to simultaneous factors like intrinsic electroactivity and surface interactions. Herein, we designed a series of shell-isolated nanostructures, with mesoporous silica shells and plasmonic Au Nanorod cores (AuNR@mSiO 2 ), for precisely investigating both LSPR and nanoconfinement effects. Single-molecule electrochemiluminescence (ECL) imaging was employed to monitor the in situ turnover frequency (TOF) of photon emissions on individual plasmonic nanoamplifiers to determine the dominant factors influencing LSPR and nanoconfinement effects. TOF heatmaps and super-resolution ECL images unveiled distinct hot spot distributions along the plasmonic nanostructures. Our approach provides insight into and in-depth understanding of plasmonic effects during electrochemical reactions, thereby facilitating precise electrocatalyst design based on the physiochemical properties of LSPR.}, archive = {J_ANGEW}, author = {Xuedong Huang and Qian Shi and Yanwei Lu and Binxiao Li and Yujun Ning and Langxia Feng and Neso Sojic and Dechen Jiang and Baohong Liu}, doi = {10.1002/anie.202508266}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508266}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-molecule electrochemiluminescence imaging of plasmonic hot spot reactivity}, volume = {64}, year = {2025}, }
• (2025). Heterointerfacial charge modulation of p-type covalent organic frameworks on graphene achieving high-performance cl− ion storage with ultralong cycling life. ANGEW, 64(35), e202508092. (www)

  @article{ , abstract = {The charge and ion transport dynamics, storage capacity, and cycling performance of Faradaic Cl − ion storage electrodes have recently constrained advancements in supercapacitor (SC) and capacitive deionization (CDI). Herein, a high-performance p-type COF (TAPA-COF)-based Cl − ion storage material (TAPArGO) with exceptional cycling stability was synthesized via an in situ condensation reaction utilizing graphene as a conductive substrate. The interfacial coupling involving graphene and TAPA-COF increases the interfacial electron density, boosting local charge accumulation and Cl − ion storage capacity. Additionally, the dual conductive strategy of incorporating graphene and extended π-electron delocalization of TAPA-COF enhances the redox kinetics, while the triphenylamine N redox centers and flexible graphene network improve cycling stability. Consequently, the Cl − ion asymmetric SC employing the TAPArGO-75 positive electrode achieves a specific energy output of 52.4 Wh kg −1 at 950 W kg −1 , with exciting cycling durability retaining 96.8% of the initial capacity after 100 000 cycles. Furthermore, the hybrid CDI system based on the TAPArGO-75 positive electrode demonstrates a specific adsorption capacity of 55.0 mg g −1 , along with remarkable cycling desalination/regeneration ability (99.8% after 200 desalination/regeneration cycles). This study expands the application potential of COF-based materials for high-performance Cl − ion storage.}, archive = {J_ANGEW}, author = {Liming Xu and Jiaxuan Wang and Yuquan Li and Yong Liu and Xingtao Xu and Zeqiu Chen and Xinjuan Liu and Likun Pan}, doi = {10.1002/anie.202508092}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterointerfacial charge modulation of p-type covalent organic frameworks on graphene achieving high-performance cl− ion storage with ultralong cycling life}, volume = {64}, year = {2025}, }
• (2025). Design strategy for small-molecule organic cathodes: Regulated active groups enable high capacity and voltage in aqueous and seawater aluminum ion batteries. ANGEW, 64(35), e202508057. (www)

  @article{ , abstract = {Organic materials demonstrate significant potential as electrodes for aqueous batteries, owing to their high theoretical capacity, structurally tunable frameworks, and sustainable material accessibility. Small-molecule organic electrode materials enable better active-site accessibility but remain challenged by the dissolution in aqueous electrolytes, which deteriorates cycling stability, and poor conductivity due to limited conjugation. Here, we designed an organic small-molecule cathode material (DPPZ-CN) featuring functional pyridine, pyrazine, and cyano groups. Its highly conjugated fused N-heteroaromatic structure provides strong intermolecular interactions and high reactivity, resulting in improved stability, capacity, and conductivity. The electron-withdrawing cyano group further modulates electron delocalization and molecular orbitals, enhancing electronic conductivity and operating voltage. Through combined theoretical and experimental studies, including operando synchrotron FT-IR, in situ Raman, ex situ XPS, and 1 H NMR, we demonstrate that DPPZ-CN facilitates efficient dual-cation storage (Al 3+ /H + ), thereby reducing Al 3+ cation repulsion and induced structural distortion. As a result, the Al//DPPZ-CN battery exhibits outstanding capacity, a well-defined voltage plateau, and an extended lifespan in organic aluminum batteries with aqueous and seawater electrolytes, highlighting its potential for operation in challenging environments.}, archive = {J_ANGEW}, author = {Hongbao Li and Mengge Cao and Rui Wang and Peng Xiong and Yangyang Liu and Lin Zhang and Leiting Zhang and Longhai Zhang and Dongliang Chao and Chaofeng Zhang}, doi = {10.1002/anie.202508057}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508057}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design strategy for small-molecule organic cathodes: Regulated active groups enable high capacity and voltage in aqueous and seawater aluminum ion batteries}, volume = {64}, year = {2025}, }
• (2025). Dual cofactor co-decorated covalent organic framework as an electron transfer regulator for biomimetic dioxygen activation. ANGEW, 64(35), e202508030. (www)

  @article{ , abstract = {Mimicking the synergy of multiple active sites of oxygenase to achieve selective O 2 activation for various oxidations is a very challenging but meaningful task. By introducing the reduced nicotinamide adenine dinucleotide (NADH) active site dihydropyridine amido (DHPA) moiety and heme, a dual cofactor co-decorated covalent organic framework (COF) was obtained to duplicate the synergistically catalytic function of the cytochrome P450 for biomimetic O 2 activation. Covalent co-decoration of dual cofactors in COFs ensures the rapid photogenerated electron transfer from DHPA to heme Fe III to generate Fe II , selectively activating O 2 to form Fe III −O 2 •− resembling the cytochrome P450 for improving the performance of alcohol oxidation, avoiding conventionally complex multistep cofactor shuttling and regeneration. Control experiments of a COF analogue containing heme but not DHPA suggested that this dual cofactor construction strategy renders COFs excellent activity and selectivity for O 2 activation. As far as we know, this represents the first case of introducing dual cofactor into COFs to echo the cytochrome P450. The well-defined structural characters and the finely modified bioactive properties open a new avenue to develop novel COFs, which not only augment the diversity of the COF family but also broaden the application of COFs in the field of biomimetic catalysis.}, archive = {J_ANGEW}, author = {Qiang Song and Yu Zhang and Liang Zhao and Zeming Wang and Cheng He and Pengyu Feng and Chunying Duan}, doi = {10.1002/anie.202508030}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202508030}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual cofactor co-decorated covalent organic framework as an electron transfer regulator for biomimetic dioxygen activation}, volume = {64}, year = {2025}, }
• (2025). Low molecular weight multistate photoswitches based on simple norbornadiene-triazine scaffolds. ANGEW, 64(35), e202507999. (www)

  @article{ , abstract = {We have synthesized and characterized a series of simple norbornadiene(NBD)-triazine architectures, including multistate photoswitches with unprecedentedly high information storage densities. The simple mono-NBDs served as suitable model systems to investigate the underlying absorption and switching characteristics. To increase the complexity stepwise, a bis -NBD derivative with a symmetric substitution pattern was investigated next. By combining different NBD substituents with varying electron demands, two asymmetric compounds, one bis -NBD and one tris -NBD, were prepared and investigated. In the case of the tris -NBD, the selective switching of the individual NBD chromophores is hampered by the too closely related optical properties of all three NBD units. On the other hand, the asymmetric photoswitch system containing two NBD-substituents fulfilled the requirements of a selectively addressable multistate system with an extremely high information storage density. Nearly all possible NBD/quadricyclane (QC) combinations could be realized here, including their reversible interconversion and the respective protonated forms. Quantum chemical calculations corroborated our experimental findings.}, archive = {J_ANGEW}, author = {Daniel Krappmann and Adrian J. Müller and Erik J. Schulze and Harald Maid and Andreas Dreuw and Andreas Hirsch}, doi = {10.1002/anie.202507999}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507999}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low molecular weight multistate photoswitches based on simple norbornadiene-triazine scaffolds}, volume = {64}, year = {2025}, }
• (2025). A single-molecule junction based on a covalent organic cage. ANGEW, 64(35), e202507894. (www)

  @article{ , abstract = {As the applications of molecular cages hinge on their properties, understanding the true nature of the cage structures is imperative. Single-molecule conductance technique offered a unique opportunity to explore the property of an individual cage structure, yet the undefined cage-electrode connection remains challenging. Herein, we designed a new single-molecule junction based on covalent organic cages with sulfur atoms on the edges as defined anchor groups. Using scanning tunneling microscopy break junction method, the single-molecule conductance was found at 10 −3.5 G ₀, indicating the formation of a stable junction by the cage. The investigation, combining control structures and theoretical studies, confirmed that the conductance signal originates from the connection between gold electrodes and sulfur atoms in adjacent benzothiadiazole groups. This well-defined connection allowed us to analyze electron transport within the cage structure, providing new insights into the property investigation of functional cages.}, archive = {J_ANGEW}, author = {Miao Yang and Sai-Sai Yan and Baogui Huang and Dong Xiang and Zhong-Ning Chen and Li-Chuan Chen and Kongzhao Su and Qian-Chong Zhang and Daqiang Yuan}, doi = {10.1002/anie.202507894}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507894}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A single-molecule junction based on a covalent organic cage}, volume = {64}, year = {2025}, }
• (2025). From corrosion to creation: Interfacial de-electronation drives hydrogenation-energy symbiosis. ANGEW, 64(35), e202507722. (www)

  @article{ , abstract = {Metal corrosion, conventionally perceived as a destructive phenomenon driven by de-electronation, imposes significant economic burdens and safety hazards. To repurpose corrosion into a valuable resource, we demonstrate a macroscopic corrosion battery concept that harnesses galvanic corrosion to drive the synthesis of metal–organic frameworks (MOFs), high-value chemicals, and energy generation, challenging conventional corrosion mitigation paradigms. By spatially segregating the corrosion process, the system couples anodic metal de-electronation with MOF deposition while integrating diverse cathodic reactions, including the hydrogen evolution reaction, oxygen reduction, electrocatalytic hydrogenation, and hydrogen peroxide reduction with remarkable accelerated kinetics, thereby achieving universal MOFs and chemical synthesis with high electron and atom utilization efficiencies. The prototype system demonstrates concurrent production of p -aminophenol (14.3 mg cm −2 h −1 ) and zinc oxalate (86.9 mg cm −2 h −1 ) while generating 34.2 mW cm −2 of electrical power. Techno-economic analysis establishes the inaugural empirical validation of economic feasibility for corrosion-driven energy-matter symbiosis, highlighting its high gross profit. Transcending conventional corrosion engineering boundaries for inorganic synthesis, this methodology mechanistically deciphers MOF growth kinetics and advanced system design. By broadening the scope of corrosion utilization, this work enables a paradigm shift from damage mitigation to value creation, providing a blueprint for sustainable chemical-energy ecosystems.}, archive = {J_ANGEW}, author = {Yueqing Wang and Xueying Cao and Chengdong Yang and Wenwen Cai and Xinxin Shu and Yuhan Li and Jing Zhu and Jizhen Ma and Jintao Zhang}, doi = {10.1002/anie.202507722}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507722}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From corrosion to creation: Interfacial de-electronation drives hydrogenation-energy symbiosis}, volume = {64}, year = {2025}, }
• (2025). Accelerating responsive RNA release through structural optimization of disulfide-containing acyl groups. ANGEW, 64(35), e202507581. (www)

  @article{ , abstract = {Chemical methods for modifying and manipulating RNA are crucial for advancing its biological studies and applications. While postsynthetic 2′-OH acylation has enabled on-demand RNA activation, its application to larger, biologically relevant RNAs remains challenging. Herein, we present a redox-responsive RNA modification via postsynthetic acylation to functionalize RNAs. Three strategies were developed to introduce multiple disulfide-containing acyl adducts at 2′-OH positions, temporarily blocking RNA function. Exposure to glutathione (GSH) can trigger the traceless release of RNA and restore its biological function. We demonstrate the versatility of this redox-responsive strategy with RNA constructs of varying lengths, including short synthetic RNA, single guide RNA (sgRNA) as well as longer messenger RNA (mRNA). Furthermore, these disulfide-containing acyl adducts respond to endogenous GSH, restoring mRNA translation without the need for cytotoxic exogenous stimuli. Taken together, these results offer a simple and generalizable method for modifying and modulating RNAs regardless of length or origin through structural optimization of acyl groups for facilitating RNA release, setting the stage for broad applicability.}, archive = {J_ANGEW}, author = {Junsong Guo and Senfeng Zhang and Tuan-Khoa Kha and Chunyi Hu and Ru-Yi Zhu}, doi = {10.1002/anie.202507581}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507581}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerating responsive RNA release through structural optimization of disulfide-containing acyl groups}, volume = {64}, year = {2025}, }
• (2025). Unlocking dual recycling in photo-curable polycyanurate thermosets derived from bio-resources. ANGEW, 64(35), e202507567. (www)

  @article{ , abstract = {Polycyanurate thermosets are extensively utilized in high-performance applications due to their exceptional thermal and mechanical properties. However, their inherently crosslinked nature has traditionally rendered them nonrecyclable, limiting their sustainability. Recent studies have demonstrated that these networks can undergo dynamic rearrangement under specific conditions, enabling reversibility. In this study, a bio-derived cyanurate monomer from eugenol was synthesized and polymerized via thiol-ene photopolymerization, yielding recyclable polycyanurate thermosets with robust material properties. The dynamic character of these networks was leveraged through nucleophilic aromatic substitution (S N Ar) chemistry, unlocking two distinct recycling pathways: i) selective monomer recovery and ii) closed-loop polymer regeneration. Depolymerization in the presence of eugenol enabled the selective recovery of well-defined monomeric components, while phenol-mediated cleavage facilitated polymer breakdown into chemically recyclable intermediates, which were directly reassembled into reformed thermosets. Both recycling pathways resulted in regenerated polymers that retained their original thermal, mechanical, and thermomechanical properties, demonstrating the efficiency and robustness of this approach. By establishing a controlled depolymerization and reassembly framework, this study introduces a sustainable design strategy for achieving closed-loop recycling in high-performance thermosets, providing a scalable pathway toward circular polymer materials.}, archive = {J_ANGEW}, author = {Özgün Dağlar and Yi-Ru Chen and Željko Tomović}, doi = {10.1002/anie.202507567}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507567}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking dual recycling in photo-curable polycyanurate thermosets derived from bio-resources}, volume = {64}, year = {2025}, }
• (2025). Deconstructive Radical–Radical coupling for programmable remote acylation. ANGEW, 64(35), e202507542. (www)

  @article{ , abstract = {Dicarbonyl compounds are structural motifs that have been extensively utilized in synthetic chemistry, and their downstream transformations have proven valuable in synthesizing numerous heterocycles. Conventional methods for accessing such compounds include the Stetter reaction, the Michael reaction, and Friedel–Crafts acylation. However, a flexible and enabling platform for obtaining all types of 1,n-dicarbonyls remains undeveloped. Reported herein is a unified approach to access a variety of 1,n-dicarbonyls through a radical-promoted deconstructive process utilizing dual photocatalysis/carbene catalysis. The utility of this strategy is demonstrated with a broad scope with robust functional group tolerance along with application in the preparation of γ-amino esters, three-component manifolds, and the first enantioselective deconstructive synthesis of 1,5-dicarbonyls using a chiral NHC catalyst.}, archive = {J_ANGEW}, author = {Jing Cao and Cullen R. Schull and Karl A. Scheidt}, doi = {10.1002/anie.202507542}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507542}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deconstructive Radical–Radical coupling for programmable remote acylation}, volume = {64}, year = {2025}, }
• (2025). Vacancy-induced atomic diffusion in a molecular metal cluster complex. ANGEW, 64(35), e202507444. (www)

  @article{ , abstract = {The presence of atomic vacancies in a close-packed material is believed to allow the migration of atoms adjacent to the vacancies, which induces dynamics of atoms. However, it is not known whether atoms in discrete molecules can undergo vacancy-induced dynamics. We describe herein the generation of a close-packed Pd 12 cluster complex [Pd 12 (C 7 H 7 ) 6 ][B(Ar F ) 4 ] n ( n = 2, 3) with a Pd-atom vacancy, and the observation of the diffusion of Pd atoms. Variable-temperature NMR analysis, X-ray structure analysis, and theoretical calculations indicate that an atomic vacancy is located at the surface sites of the Pd 12 core, and that it migrates rapidly on the NMR timescale. This means that all 11 palladium atoms at the surface undergo self-diffusion with a low energy barrier. These results demonstrate, for the first time, that atomic diffusion occurs within a molecule through the vacancy mechanism.}, archive = {J_ANGEW}, author = {Kosuke Iwata and Koshi Miyazawa and Kenta Kurashima and Hiroshige Yamaura and Bo Zhu and Yu Tian and Yuta Takahira and Koji Yamamoto and Tsubasa Omoda and Daisuke Hashizume and Shigeyoshi Sakaki and Tetsuro Murahashi}, doi = {10.1002/anie.202507444}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vacancy-induced atomic diffusion in a molecular metal cluster complex}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bonding-assisted assembly of stable high-nuclearity Copper(I)-alkyne nanoclusters for X-ray scintillation. ANGEW, 64(35), e202507412. (www)

  @article{ , abstract = {The construction of high-nuclearity, atomically precise copper(I)-alkyne nanoclusters remains a formidable challenge due to their high reactivity and strong aggregation tendency. Here, we report a hydrogen-bonding-assisted assembly strategy that enables the ambient-condition synthesis of two robust copper(I)-alkyne nanoclusters. Single-crystal X-ray diffraction reveals the different core structures including [(C 2 ) 8 @Cu 50 ] ( Cu50 ) and [(C 2 ) 10 @Cu 56 ] ( Cu56 ). Both clusters feature distinctive metal shells stabilized by synergistic Cu─C/O coordination interactions and an extensive outer-layer hydrogen-bonding network between the hydroxyl groups of 2-methyl-3-butyn-2-ol  and CF 3 COO − ligands, enhancing molecular rigidity and inoxidizability. Notably, Cu50 displays strong yellow phosphorescence and prominent X-ray-excited luminescence (XEL). More significantly, it represents the first high-nuclearity copper nanocluster to be processed into a scintillator film, which exhibits promising X-ray imaging performance. The present work not only establishes a generalizable hydrogen-bond-assisted assembly strategy for constructing stable, high-nuclearity copper(I)-alkyne nanoclusters, but also demonstrates their practical applicability in X-ray scintillation, providing new insights into the synthetic design and functional diversification of nanocluster-based materials.}, archive = {J_ANGEW}, author = {Bao-Liang Han and Fahri Alkan and Zhi-Rui Yuan and Paritosh Mahato and Zhi Wang and Chen-Ho Tung and Di Sun}, doi = {10.1002/anie.202507412}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507412}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bonding-assisted assembly of stable high-nuclearity Copper(I)-alkyne nanoclusters for X-ray scintillation}, volume = {64}, year = {2025}, }
• (2025). Side-on coordination in molecular alkaline earth metal hypofluorites FM(η2-OF) (M = mg, ca, sr, and ba). ANGEW, 64(35), e202507151. (www)

  @article{ , abstract = {Side-on coordinated molecular hypofluorites FM(η 2 -OF) (M = Mg, Ca, Sr, and Ba) were prepared by co-deposition of laser-ablated alkaline earth metal atoms with diluted OF 2 in cryogenic matrices. The structures parallel the non-VESPR structures of alkaline earth metal difluorides and dihydrides, such that FMg(η 2 -OF) is planar, FCa(η 2 -OF) is planar but with a shallow bending-potential curve, while FSr(η 2 -OF) and FBa(η 2 -OF) are non-planar. Bonding analyses show that the interactions between the metal center M 2+ and the negatively charged ligands F − and OF − are mainly electrostatic. Moreover, for FMg(η 2 -OF), donation of electron density from OF − to empty s and p orbitals of magnesium is involved. However, for the heavier alkaline earth metal compounds, the donation to empty d orbitals of the metal center becomes dominant in orbital interactions, which contributes to their non-planar structures.}, archive = {J_ANGEW}, author = {Xiya Xia and Robert Medel and Sebastian Riedel}, doi = {10.1002/anie.202507151}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Side-on coordination in molecular alkaline earth metal hypofluorites FM(η2-OF) (M = mg, ca, sr, and ba)}, volume = {64}, year = {2025}, }
• (2025). Orbital coupling-engineered coordination-unsaturated CuAg nanochains drives spontaneous electrocatalytic acetylene semihydrogenation and zn-C2H2 batteries. ANGEW, 64(35), e202507004. (www)

  @article{ , abstract = {Electrocatalytic semihydrogenation of acetylene (C 2 H 2 ) offers a mild and sustainable pathway for ethylene production, yet it faces critical challenges including competitive C─C coupling for 1,3-butadiene due to insufficient proton supply and hydrogen evolution under high current densities. To address these limitations, we design a coordination-unsaturated CuAg bimetallic catalyst with cross-linked nanochains (Cu 0.5 Ag CNCs), which synergistically regulates proton dynamics, maintaining high activity from 0.1 to 0.6 A cm −2 and achieving an ethylene Faradaic efficiency of 95.1% at 0.5 A cm −2 . Mechanistic studies reveal that the introduction of Cu makes the d-band center in Cu 0.5 Ag CNCs upshift toward the Fermi level, strengthening orbital coupling with C 2 H 2 and creating a high *H demand surface. In situ spectroscopic and density functional theory analyses demonstrate that coordination-unsaturated Cu-Ag interfacial sites promote spontaneous C 2 H 2 hydrogenation, especially bypassing formation barriers of *C 2 H 2 and *C 2 H 3 . This thermodynamic superiority originates from sufficient proton supply and exothermic *H consumption for C 2 H 2 hydrogenation. Furthermore, the catalyst enables a Zn-C 2 H 2 battery with a power density of 2.12 mW cm −2 , showcasing dual functionality in electrosynthesis and energy storage. Our work establishes a paradigm for coordination unsaturated bimetallic catalyst design through orbital coupling engineering, providing atomic-level insights into proton-mediated reaction control for sustainable chemical manufacturing.}, archive = {J_ANGEW}, author = {Xing Gao and Rui Bai and Shuyue Wang and Chen Sun and Yiyuan Lu and Ziyu Song and Chengtao Wang and Siyu Yao and Shaodong Zhou and Zhongjian Li and Yang Hou and Lecheng Lei and Jian Zhang and Bin Yang}, doi = {10.1002/anie.202507004}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202507004}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orbital coupling-engineered coordination-unsaturated CuAg nanochains drives spontaneous electrocatalytic acetylene semihydrogenation and zn-C2H2 batteries}, volume = {64}, year = {2025}, }
• (2025). Selective and energy efficient electrocatalytic CO2-to-ethanol conversion through anion modulation. ANGEW, 64(35), e202506867. (www)

  @article{ , abstract = {Ethanol, with its high market value and stable global demand, stands out as an attractive product of electrocatalytic CO 2 reduction. However, achieving high ethanol selectivity and energy efficiency at industrial current densities remains challenging. In this study, we employed a blended anion modulation strategy to enhance the selectivity and energy efficiency of CO 2 -to-ethanol conversion. The Cu 2 (OH) 3 F pre-catalyst achieved Faradaic efficiencies of 50% and 93% for ethanol and C 2+ , respectively, at 700 mA cm −2 in a blended electrolyte consisting of 2 M KOH and 1 M KCl. Comprehensive electrochemical tests, combined with in situ characterizations and theoretical analysis, revealed that chloride and hydroxide increased *CO coverage for efficient C─C coupling. Moreover, hydroxide stabilizes the *CHCOH intermediate through hydrogen bonding with the adsorbed hydroxide on the catalyst surface, while Cl synergistically enhances its reactivity by promoting water dissociation toward the ethanol pathway.}, archive = {J_ANGEW}, author = {Yumin Da and Jie Chen and Lei Fan and Rui Jiang and Yukun Xiao and Meng Wang and Ganwen Chen and Zhangliu Tian and Hanqian Zhang and Hongqiang Jin and Xiang Chen and Chenrui Ji and Shibo Xi and Yanwei Lum and Lei Wang and Tong Zhu and Jia Zhang and Wei Chen}, doi = {10.1002/anie.202506867}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506867}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective and energy efficient electrocatalytic CO2-to-ethanol conversion through anion modulation}, volume = {64}, year = {2025}, }
• (2025). Developing HaloTag and SNAP-tag chemical inducers of dimerization to probe receptor oligomerization and downstream signaling. ANGEW, 64(35), e202506830. (www)

  @article{ , abstract = {Controlling protein–protein interactions is critical for dissecting signaling pathways, especially those initiated by ligand-receptor interactions, which alter receptor oligomerization and drive downstream signaling cascades. Traditional methods for driving protein–protein complexes use antibodies that face limitations in terms of stoichiometry, geometric rigidity, and antibody specificity. Chemical inducers of dimerization (CIDs) for fusion proteins such as HaloTag (Halo) and SNAP-Tags (SNAP) offer precise and covalent control of protein proximities, overcoming limitations of antibody-dependent methods. In this study, we expand the toolkit of Halo and SNAP CIDs with (1) benzylguanine (BG) and HaloTag ligand (HTL) crosslinkers featuring varying polyethylene glycol linker lengths and update this kit with (2) a FRET-based dimerizing sensor to induce and verify protein proximity. Here we establish our CIDs on extracellularly Halo- and SNAP-tagged TGFβ, BMP, neurotrophic factor, and metabotropic glutamate receptors, thereby elucidating the signaling potential of ligand-independent dimerization in a heteromeric fashion.}, archive = {J_ANGEW}, author = {Michael Trumpp and Blaise Gatin-Fraudet and Kjell Bruckmann and Wiktor Burdzinski and Kilian Roßmann and Joshua Levitz and Petra Knaus and Jerome Jatzlau and Johannes Broichhagen}, doi = {10.1002/anie.202506830}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Developing HaloTag and SNAP-tag chemical inducers of dimerization to probe receptor oligomerization and downstream signaling}, volume = {64}, year = {2025}, }
• (2025). Design of fluorine-free weakly coordinating electrolyte solvents with enhanced oxidative stability. ANGEW, 64(35), e202506826. (www)

  @article{ , abstract = {High concentrations of conducting salt in electrolyte formulations enhance the agglomeration of ionic species, which has been demonstrated to yield anion-derived electrode–electrolyte interphases and improved reversibility in several battery configurations. However, industrial application of these electrolytes may be limited due to high costs of electrolyte conducting salts. Here, weakly solvating electrolyte solvents with tailored coordination strength have been established as an approach to achieve ionic agglomeration at moderate conducting salt concentrations and without per-fluorinated diluents. However, the inevitable presence of uncoordinated solvent molecules in this electrolyte concept renders them susceptible to oxidative decomposition. Although previous efforts demonstrated fluorination as an effective design strategy to tailor the oxidative stability of weakly solvating electrolytes, the per-fluorinated solvents are toxic and harmful to the environment. Herein, the incorporation of silicon is evaluated as an eco-friendly approach to dispel electron density of the oxygen lone pair. Though steric demand of substituents is already sufficient to tailor the coordination strength, negative hyperconjugation effectively expands the oxidative stability limit of weakly solvating electrolytes. Combining ion agglomeration and intrinsic oxidative stability, the herein introduced weakly solvating electrolyte enables a notable improvement of reversibility under eco-friendly conditions, presenting a valid alternative to fluorinated electrolyte solvents.}, archive = {J_ANGEW}, author = {Lennart Wichmann and Adil Aboobacker and Steffen Heuvel and Felix Pfeiffer and Robert-Tobias Hinz and Frank Glorius and Isidora Cekic-Laskovic and Diddo Diddens and Martin Winter and Gunther Brunklaus}, doi = {10.1002/anie.202506826}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506826}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of fluorine-free weakly coordinating electrolyte solvents with enhanced oxidative stability}, volume = {64}, year = {2025}, }
• (2025). A “Cocktail” fluorescent probe for multi-ROS imaging unveils ferroptosis-driven liver fibrosis development. ANGEW, 64(35), e202506728. (www)

  @article{ , abstract = {Liver fibrosis is a pathological repair response to chronic liver injury and may progress to cirrhosis, liver failure, or hepatocellular carcinoma if untreated. Currently, no approved therapies specifically target advanced liver fibrosis, thus exploring the molecular mechanisms underlying liver fibrosis has become crucial. Previous studies have highlighted significant controversy regarding the role of ferroptosis in liver fibrosis. Given that reactive oxygen species (ROS) serve as key mediators to both processes, ROS may serve as a molecular nexus connecting ferroptosis and liver fibrosis. To comprehensively elucidate the molecular network involving ROS and ferroptosis in liver fibrosis, we designed and synthesized the first multi-functional “cocktail” fluorescence probe, FP-ROS, enabling highly sensitive and selective simultaneous imaging of O 2 •− , H 2 O 2 , and ONOO − . FP-ROS was successfully employed to assess ferroptosis levels in the livers of fibrosis mice following drug intervention. Combining transcriptomic and proteomic analyses, we elucidated the signaling pathway NOX→ONOO − →GCLM(C46)→GSH→ferroptosis→hepatic stellate cells (HSCs) activation. This study demonstrates that ferroptosis plays a critical role in HSCs activation and further elucidates the molecular interplay between ROS and ferroptosis in fibrosis progression. These findings provide novel insights into the diagnosis and therapeutic strategies for liver fibrosis.}, archive = {J_ANGEW}, author = {Hui Wang and Hongtong Wang and Tiancong Xiu and Xiaoting Zhang and Yue Tang and Wei Zhang and Wen Zhang and Ping Li and Bo Tang}, doi = {10.1002/anie.202506728}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506728}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A “Cocktail” fluorescent probe for multi-ROS imaging unveils ferroptosis-driven liver fibrosis development}, volume = {64}, year = {2025}, }
• (2025). Framework nucleic acid-mediated DNAzyme chaperoning for sensitive trace metal ion mapping on live neuronal cell membranes. ANGEW, 64(35), e202506640. (www)

  @article{ , abstract = {The transient release of metal ions at neuronal cell membranes holds significant implications in neurophysiology and pathology. Consequently, there is a pressing need for sensitive methodologies capable of quantitatively mapping local metal ion concentrations in live cells, aiming to unravel potential mechanisms underlying neurological disorders. DNAzymes have emerged as versatile tools for metal ion detection in live cells, owing to their specificity and other inherent advantages. Efforts to broaden their utility have focused on enhancing the stability and sensitivity of DNAzymes. Inspired by the beneficial effects of molecular chaperones on the stability and functionality of proteins, we present in this study the development of tetrahedral DNA frameworks (TDF) as chaperones for DNAzymes, aiming at enhancing the stability and activity of DNAzymes. Integration of TDF with DNAzymes is shown to significantly enhance metal ion detection performance, resulting in elevated stability and a two-fold increase in sensitivity, attributed to alterations in the local net charge induced by TDF. In vitro investigations demonstrate that the nanodevice developed here faithfully maps Cu 2+ concentrations within a range of 0–10 µM on the membrane of neuronal cells, meeting the requirements for Cu 2+ sensing under both physiological and pathological conditions. This work presents an easily adaptable approach to enhance the performance of DNAzymes and lays the foundations for the development of other DNAzyme-based sensitive detection nanodevices.}, archive = {J_ANGEW}, author = {Tianqi Xu and Fan Li and Yichao Jin and Feng Jia and Yu Wang and Tao Lv and Yueyue Zhang and Min Li and Chunhai Fan and Mingqiang Li and Xiaohua Zhang and Shaopeng Wang and Xiaolei Zuo}, doi = {10.1002/anie.202506640}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Framework nucleic acid-mediated DNAzyme chaperoning for sensitive trace metal ion mapping on live neuronal cell membranes}, volume = {64}, year = {2025}, }
• (2025). Revealing the correlation of loading-to-performance of single atom catalysts. ANGEW, 64(35), e202506563. (www)

  @article{ , abstract = {The correlation between metal loading and overall catalytic performance remains elusive for single-atom electrocatalysts (SACs), which hinders the oriented optimization of active site densities and scalable synthesis of them. To effectively address this issue, Ru single atoms with different loading are anchored on the graphene-like framework and tungsten carbide substrate (WC 1-x ) to investigate the synergistic effect among different local configurations. X-ray absorption spectroscopy demonstrated that the loading of Ru atoms critically governs the interatomic distance between adjacent metal active sites at second shell coordination. In situ Raman spectroscopy shows that WC 1-x nanoparticles can break the hydrogen bond network by reorienting H 2 O molecule adsorption and promoting the availability of active H 2 O among electrode-electrolyte interface. Density functional theory (DFT) calculations demonstrated that the moderate distance between active sites could further lower the reaction barrier and enhance the catalytic activity. Consequently, the optimal sample Ru-WC 1-x with 0.76 wt% Ru loading exhibits a low overpotential of 7 mV at 10 mA⋅cm −2 and the anion exchange membrane electrolyzer to stably operate for 100 h at 1 A⋅cm −2 . Such correlation of spatial effects between different active sites were universally demonstrated in similar systems anchored with either Pt, Ir, or Co elements.}, archive = {J_ANGEW}, author = {Hui Zhang and Jie Wang and Jixin Yao and Qun Yang and Xueqin Zuo and Huaibao Tang and Wen Wang and Li Yang and Guang Li}, doi = {10.1002/anie.202506563}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506563}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing the correlation of loading-to-performance of single atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Symmetry breaking enabled stable oxygen redox in li-rich cathodes via π-type interaction. ANGEW, 64(35), e202506507. (www)

  @article{ , abstract = {Effectively stabilizing oxygen redox is the most challenging task for the practical applications of high-energy-density Li-rich cathode materials. However, how to accurately tune the oxygen energy level to achieve reversible redox remains puzzling so far. In this work, we achieve stable oxygen redox in layered Li-rich materials over the whole voltage range without irreversible O 2 release by adjusting the interlayer metal cation environment adjacent to the ligand. Combining synchrotron X-ray absorption spectroscopy and theoretical analysis of metal-ligand orbital combinations, we confirm the obvious charge transfer from O to Ni due to the π-type interaction between Ni 3 d spin-down t 2g orbitals and O 2 p orbitals. Furthermore, Ab initio molecular dynamics simulations reveal the spontaneous symmetry breaking of the Ni coordination environment after Li extraction under the π-type interaction, which enhances the intrinsic competition between anion and cation oxidation, keeping π* state (from O 2 p splitting) below the metal band to avoid over-oxidation. As a result, the modified material shows improved electrochemical performance and stable structural/interface evolution. This work provides new insights into the relationship between the adjacent metal environment and the ligand O redox reactions.}, archive = {J_ANGEW}, author = {Fu-Da Yu and Zhe-Jian Yi and Hai-Nan Wang and Jia-Zhen Zhao and Yang-Qian Zhang and Yang Ren and Ji-Gang Zhou and Ji-Huai Wu and Zhang Lan and Yi-Ming Xie and Lan-Fang Que and Yun-Shan Jiang and Zhen-Bo Wang}, doi = {10.1002/anie.202506507}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506507}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Symmetry breaking enabled stable oxygen redox in li-rich cathodes via π-type interaction}, volume = {64}, year = {2025}, }
• (2025). High-pressure synthesis of crystalline double-layer carbon nitride networks stabilized in Bi7C10N18(N3(1-x)O3x). ANGEW, 64(35), e202506406. (www)

  @article{ , abstract = {Application of high-pressure conditions in chemical synthesis has proven to access a wide range of novel nitrogen-rich compounds and to overcome the stability of the dinitrogen molecule. In the present work, we report the high-pressure high-temperature (HPHT) synthesis of Bi 7 C 10 N 18 (N 3(1- x ) O 3 x ), which features double-layers of poly- N -(1,3,5-triazin-2- yl )-guanidine [C 4 N 6 x - ] n and non-polymerized guanidinate anions CN 3 5- . The structure model was determined by means of synchrotron single-crystal X-ray diffraction and is fully corroborated by theoretical calculations. The poly- N -(1,3,5-triazin-2- yl )-guanidine illustrates an example of a 2D polymerized anionic C─N network and represents the first intermediate between highly charged CN 3 5− anions and fully condensed graphitic carbon nitride networks achieved by HPHT conditions. This opens a pathway to a widely varied family of hydrogen-free nitridocarbonates, which has the potential to develop into an alternative synthesis route to classical polycondensation reactions.}, archive = {J_ANGEW}, author = {Lukas Brüning and Nityasagar Jena and Pascal L. Jurzick and Elena Bykova and Nico Giordano and Mohamed Mezouar and Igor A. Abrikosov and Maxim Bykov}, doi = {10.1002/anie.202506406}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506406}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-pressure synthesis of crystalline double-layer carbon nitride networks stabilized in Bi7C10N18(N3(1-x)O3x)}, volume = {64}, year = {2025}, }
• (2025). Regulate the Singlet–Triplet energy gap by spatially separating HOMO and LUMO for high performance organic photovoltaic acceptors. ANGEW, 64(35), e202506357. (www)

  @article{ , abstract = {Reducing the single-triplet energy gap (∆ E ST ) for organic photovoltaic (OPV) molecules has been proposed to be able to reduce the nonradiative recombination by tuning the low-lying triplet state (T 1 ) and/or the excited state (S 1 ), thus reducing the energy loss ( E loss ) and increasing the open-circuit voltage in their devices. However, how to design the non-fullerene acceptor (NFA) with small ∆ E ST and high performance is challenging. Aiming to address this issue, YDF , YTF , and YTF-H were synthesized. Among them, a device based on YDF with partially spatially separated highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) exhibits a much higher power conversion efficiency (PCE) of 20.04%, which is one of the most efficient efficiencies for binary systems. For YTF and YTF-H , their completely spatially separated HOMO and LUMO indeed lead to a much reduced ∆ E ST caused by the low-lying S 1 state, together with excellent charge mobility and light absorption, required for higher performance OPV. But their low S 1 state causes several non-radiative recombinations due to strong S 1 -S 0 coupling (PCE < 1.5%). These results indicate that future designs to have high performance molecules with small ∆ E ST should avoid the sharp decrease in S 1 , and the ideal scenario would be to elevate the T 1 state, thereby mitigating the energy gap law.}, archive = {J_ANGEW}, author = {Guangkun Song and Tengfei He and Ruohan Wang and Yanni Ouyang and Nakul Jain and Saisai Liu and Bin Kan and Yujie Shang and Jiaqi Li and Xingkai Wang and Zhaoyang Yao and Xiangjian Wan and Chenxi Li and Wei Ma and Yan Zhao and Guankui Long and Chunfeng Zhang and Feng Gao and Yongsheng Chen}, doi = {10.1002/anie.202506357}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulate the Singlet–Triplet energy gap by spatially separating HOMO and LUMO for high performance organic photovoltaic acceptors}, volume = {64}, year = {2025}, }
• (2025). Total synthesis and structural revision of (−)-sodagnitin e. ANGEW, 64(35), e202506247. (www)

  @article{ , abstract = {We report the total synthesis of malabaricane triterpene sodagnitin E, marking the first synthesis of any malabaricane natural product to date. The enantioselective synthesis of two key fragments, followed by their coupling via a Mukaiyama aldol reaction delivered the triterpene framework in a convergent synthesis. A thorough analysis of the synthetic material led to the elucidation of a previously unassigned stereocenter (C17) as well as the reassignment of the configuration at C27. This enabled the structural revision of the relative configuration at the central lactol moiety.}, archive = {J_ANGEW}, author = {Philipp Schoch and Tanja Gaich}, doi = {10.1002/anie.202506247}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506247}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis and structural revision of (−)-sodagnitin e}, volume = {64}, year = {2025}, }
• (2025). Gram-scale access to (3,11)-Cyclotaxanes—Synthesis of 1-hydroxytaxuspine c. ANGEW, 64(35), e202506245. (www)

  @article{ , abstract = {Herein, we present the semisynthesis of complex taxane diterpenoid 1-hydroxytaxuspine C. Starting from cheap and abundant 10-deacetylbaccatin III, a scalable and robust route was developed, enabling an unprecedented gram-scale access to the intricate (3,11)-cyclotaxane scaffold. In addition, this represents the first synthetic access to C1-hydroxylated cyclotaxanes. The natural product is synthesized in 17 steps, with the reactions being performed on decagram-scale up to an advanced intermediate, establishing the scalability of this approach.}, archive = {J_ANGEW}, author = {Philipp Schoch and Yulia Krivolapova and Fabian Schneider and Lu Pan and Tanja Gaich}, doi = {10.1002/anie.202506245}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506245}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gram-scale access to (3,11)-Cyclotaxanes—Synthesis of 1-hydroxytaxuspine c}, volume = {64}, year = {2025}, }
• (2025). Regio-, diastereo-, and enantioselective hydrosilylation of alkyl gem-difluoroalkenes to construct carbon and silicon stereogenic centers. ANGEW, 64(35), e202506157. (www)

  @article{ , abstract = {The asymmetric hydrofunctionalization of aliphatic alkenes without auxiliary or stabilizing groups presents a significant challenge in modern organic synthesis. We report herein the nickel-catalyzed enantioselective hydrosilylation of alkyl-substituted gem -difluoroalkenes, which enables the generation of chiral α-difluoromethylsilanes with excellent regio- and enantioselectivity. Moreover, the simultaneous construction of carbon- and silicon-stereogenic centers was achieved with excellent diastereo- and enantioselectivity using prochiral silanes. This method provides an efficient approach to access sp 3 -enriched C-stereogenic centers equipped with high-value difluoromethyl groups. The resulting enantioenriched silanes could undergo a range of stereospecific transformations. Density functional theory (DFT) calculations were performed to elucidate the detailed mechanism.}, archive = {J_ANGEW}, author = {Huanhuan Li and Yan Qiao and Ming Li and Fen Wu and Hao Wu and Junbiao Chang and Dachang Bai}, doi = {10.1002/anie.202506157}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506157}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regio-, diastereo-, and enantioselective hydrosilylation of alkyl gem-difluoroalkenes to construct carbon and silicon stereogenic centers}, volume = {64}, year = {2025}, }
• (2025). EDTA-mg nano-chelators amplify ferroptosis by artificially simulating the epithelial-mesenchymal transition process and endogenous iron deprivation. ANGEW, 64(35), e202506126. (www)

  @article{ , abstract = {Epithelial-mesenchymal transition (EMT) is a key step in initiating tumor metastasis. Commonly, researchers focus on inhibiting EMT to prevent tumor metastasis. However, they ignore that tumor cells undergoing EMT are more vulnerable to disturbance from the external environment. Tumor cells in this period are a potential therapeutic target, yet precisely regulating the EMT of tumor cells remains a challenging problem to be solved. Here, based on metal chelation therapy, we propose a strategy of artificially mimicking EMT, integrating ferroptosis and immunotherapy to inhibit tumor growth and metastasis. The prepared ethylene diamine tetraacetic acid-magnesium (EDTA-Mg), on the one hand, chelates Ca 2+ on the surface of tumor cells to form EDTA-Ca, causing the dissociation of tumor cells. Meanwhile, E-cadherin is downregulated, while Vimentin and matrix metalloproteinase 2 (MMP-2) are upregulated, indicating the occurrence of EMT. On the other hand, after EDTA-Ca is endocytosed by tumor cells, it deprives Fe in the lysosomes to form EDTA-Fe, which induces ferroptosis through a Fenton reaction. Ferroptosis, combined with the initially released Mg 2+ , synergistically amplifies the immune response, thereby inhibiting tumor metastasis. To the best of our knowledge, such a strategy of artificially simulating EMT for tumor treatment has hitherto not been reported.}, archive = {J_ANGEW}, author = {Yulin Xie and Tengfei Jiang and Junrong Wang and Yanrong Qian and Wencheng Xu and Guanghui Zhao and Haidong Gao and Chunxia Li}, doi = {10.1002/anie.202506126}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506126}, shortjournal = {Angew. Chem. Int. Edit.}, title = {EDTA-mg nano-chelators amplify ferroptosis by artificially simulating the epithelial-mesenchymal transition process and endogenous iron deprivation}, volume = {64}, year = {2025}, }
• (2025). Homologous ladder cyclohexasilanes. ANGEW, 64(35), e202506054. (www)

  @article{ , abstract = {We report the synthesis of five new examples of ladder cyclohexasilanes, possessing up to three consecutive fused rings and differing in relative ring fusion configuration and side chain structure. By coupling a 1,4-dipotassiooligosilyl dianion to a cyclohexasilane, we obtained bi- and tricyclic ladder cyclohexasilanes. Combined experimental and theoretical studies suggested that annulation could favor the cis configuration under kinetic control, while the trans configuration predominates under thermodynamic control. Computational studies show that with each additional ring in the trans -diastereomeric series, the predicted onset of light absorption shifts to longer wavelengths.}, archive = {J_ANGEW}, author = {Fan Fang and Andrew Molino and Kelsie E. Wentz and Carlton P. Folster and Jessica L. Williams and Maxime A. Siegler and Rebekka S. Klausen}, doi = {10.1002/anie.202506054}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202506054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Homologous ladder cyclohexasilanes}, volume = {64}, year = {2025}, }
• (2025). In situ electrochemical reconstruction of cation-vacancy-enriched Ni@Ni2P particles in hollow N-doped carbon nanofibers for efficient nitrate reduction. ANGEW, 64(35), e202505948. (www)

  @article{ , abstract = {Electrochemical nitrate (NO 3 − ) reduction to ammonia (NH 3 ) under ambient conditions is promising to promote the artificial nitrogen cycling. Despite the development of transition metal-based catalysts, their incident in situ electrochemical reconstruction always leads to the ambiguity of veritable active sites and reaction mechanisms. In this work, we report an approach to encapsulate Ni@Ni 2 P particles with cationic Ni vacancies in hollow N-doped carbon nanofibers (designated Ni@Ni 2- x P@N-CNFs) for electrocatalytic NO 3 − reduction to NH 3 and have investigated their surface reconstruction and reaction mechanisms using various in situ electrochemical characterizations and theoretical calculations. Specially, the regulation of cationic Ni vacancy concentration in the three defective Ni@Ni 2- x P@N-CNFs catalysts leads to the 3.92-fold NH 3 yield rate difference at −0.2 V versus RHE. During the electrocatalytic reaction process, new amorphous Ni(OH) 2 and NiOOH species form on the surface of Ni@Ni 2- x P@N-CNFs and the stable amorphous Ni(OH) 2 species benefits the generation of more active hydrogen (*H) for hydrogenation with NO 3 − . This is further verified by the different reaction rate-determining steps on the pristine and reconstructed defective catalysts. Integration of the optimized defective catalyst as cathode into a stable aqueous Zn–NO 3 –battery provides high power density and Faraday efficiency for NH 3 .}, archive = {J_ANGEW}, author = {Rong Gao and Jiangwei Zhang and Guilan Fan and Xiaosong Wang and Fengyu Ding and Yan Guo and Chenhui Han and Yuliang Gao and Ao Shen and Junfang Ding and Limin Wu and Xiaojun Gu}, doi = {10.1002/anie.202505948}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505948}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ electrochemical reconstruction of cation-vacancy-enriched Ni@Ni2P particles in hollow N-doped carbon nanofibers for efficient nitrate reduction}, volume = {64}, year = {2025}, }
• (2025). Breaking the activity-selectivity trade-off in direct levulinate hydrodeoxygenation to pentanoic biofuels over la-modulated ru-zeolite catalysts. ANGEW, 64(35), e202505871. (www)

  @article{ , abstract = {Disentangling the activity-selectivity trade-off in hydrodeoxygenation (HDO) of biomass-derived oxygenates has been a great challenge in biomass valorization and related tandem catalysis, by virtue of involving a series of reactions in parallel and in cascade. Herein, we demonstrate the importance of La modulation for Ru-zeolite combinations in the case of direct HDO of neat ethyl levulinate (EL) into ethyl pentanoate (EP). An unprecedented EP yield of 80% and an EP turnover rate (TOR) of 224 mol EP ·mol Ru −1 ·h −1 , together with excellent stability, were obtained for the optimal Ru/2.8La-Y catalyst for the first time, compared to the current reported “performance ceiling” of EP yields of <40% and EP TORs of <120 mol EP ·mol metal −1 ·h −1 under similar conditions. Optimal La modulation could maximize the density of the active Brønsted acid sites and efficiently attenuate the acid strength, thus enhancing both activity and selectivity in the direct HDO of EL into EP while suppressing the further hydrolysis reactions that consume EP. This study provides an effective approach to regulate the acid properties of metal-zeolite bifunctional catalysts, in particular in mediation of compromise in acid density and acid strength factors, for breaking the activity-selectivity trade-off in biomass valorization and beyond.}, archive = {J_ANGEW}, author = {Lu Lin and Jiang He and Xiaodan Yan and Haifeng Qi and Tiehong Chen and Jinlu He and Yuanshuai Liu and Zhijie Wu and Jian Liu and Wenhao Luo}, doi = {10.1002/anie.202505871}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505871}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking the activity-selectivity trade-off in direct levulinate hydrodeoxygenation to pentanoic biofuels over la-modulated ru-zeolite catalysts}, volume = {64}, year = {2025}, }
• (2025). Magneto-luminescence thermometry with magnetic circularly polarized luminescence. ANGEW, 64(35), e202505806. (www)

  @article{ , abstract = {Lanthanide(III) materials display remarkable optical properties, making them valuable for advancing remote luminescent sensors. The narrow emission bands and energy-transfer processes can be tailored to respond to external stimuli, such as temperature changes and magnetic fields. The application of magnetic fields lifts the Zeeman degeneracy, creating electronic spin polarization, and giving rise to magneto-optical phenomena. Magnetic circularly polarized luminescence (MCPL) is a magneto-optical technique in which the differential emission of left and right circularly polarized light is induced by a magnetic field oriented parallel or antiparallel to the light propagation axis. In the context of lanthanide(III) materials, this technique has only been explored in a few studies as a characterization tool. In this study, we present MCPL for a Dy(III) complex for the first time, highlighting its significant potential for magneto-luminescence thermometry. By studying the [Dy(acac) 3 (phen)] complex (phen: 1,10-Phenanthroline; acac: acetylacetonate) as an example, a maximum relative sensitivity of 19.7% K −1 was observed at 293 K, highlighting the tremendous potential that MCPL emitters hold in the field of luminescent thermometers.}, archive = {J_ANGEW}, author = {Diogo Alves Gálico and Muralee Murugesu}, doi = {10.1002/anie.202505806}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505806}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Magneto-luminescence thermometry with magnetic circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Multipoint coordinative capture of olefinic substrates utilizing metal-carbon bonds by macrocyclic complex. ANGEW, 64(35), e202505734. (www)

  @article{ , abstract = {Terpenoids and unsaturated fatty acids containing C═C double bonds are biologically and synthetically important compounds. The transformation of these substrates catalyzed by proteins relies on precise molecular capture. However, achieving precise molecular recognition of C═C double bonds using synthetically designed hosts remains a significant challenge. We now report a macrocyclic palladium tetranuclear complex that functions as a synthetic receptor featuring coordination sites within its inner cavity. This receptor selectively binds specific double bonds of unsaturated hydrocarbon substrates. Squalene (C 30 H 50 ), a linear triterpene with chemically similar six isoprenoid units, was captured by the macrocyclic complex through the coordination of four out of the six C═C double bonds, leading to a unique host-guest complex with a folded-squalene structure. Furthermore, the macrocyclic complex exhibited stronger binding affinity for methyl linolenate compared to methyl oleate or methyl linoleate through multipoint coordinative capture. This unprecedented approach to multipoint coordination of specific unsaturated bonds contrasts sharply with biological and traditional artificial receptors, which typically rely on intermolecular interactions such as hydrogen bonding or hydrophobic effects. By achieving precise capture and folding of flexible olefinic substrates, this study establishes a new paradigm for the design of artificial host molecules and a novel platform for enzyme-like reaction vessels.}, archive = {J_ANGEW}, author = {Kohtaro Sugawara and Kenichiro Omoto and Takashi Nakamura}, doi = {10.1002/anie.202505734}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505734}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multipoint coordinative capture of olefinic substrates utilizing metal-carbon bonds by macrocyclic complex}, volume = {64}, year = {2025}, }
• (2025). Thermodynamics of water displacement from binding sites and its contributions to supramolecular and biomolecular affinity. ANGEW, 64(35), e202505713. (www)

  @article{ , abstract = {The role of water displacement in noncovalent binding has been debated in the fields of supramolecular chemistry and drug design. We use molecular dynamics simulations of idealized host-guest systems to address the long-standing controversy of whether water is merely a bystander or an actual driver of noncovalent binding in aqueous solution. To isolate hydration effects, we consider a pseudo-hard-sphere guest binding to a series of cucurbit[8]uril-based macrocyclic host models whose energetic interactions with water vary widely. The computed free energy cost of displacing water from binding sites ranges from 0 to +37 kcal mol −1 , strongly influencing binding affinities. However, neither water density nor excess chemical potential reliably indicates the thermodynamic favorability of cavity water. These results support the concept that “unfavorable” binding site water contributes to high-affinity binding and resolve the paradox of stable but thermodynamically unfavorable cavity water. This work provides insights into the nature of the hydrophobic effect in molecular recognition and offers a framework for understanding the role of water in binding across various host-guest and protein-ligand systems.}, archive = {J_ANGEW}, author = {Jeffry Setiadi and Frank Biedermann and Werner M. Nau and Michael K. Gilson}, doi = {10.1002/anie.202505713}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505713}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermodynamics of water displacement from binding sites and its contributions to supramolecular and biomolecular affinity}, volume = {64}, year = {2025}, }
• (2025). PyBOX-integrated chiral covalent organic frameworks. ANGEW, 64(35), e202505329. (www)

  @article{ , abstract = {Heterogeneous catalysts based on chiral covalent organic frameworks (CCOFs) are the new sensation in asymmetric catalysis. The pyridine-bis(oxazoline) (PyBOX), on the other hand, is a well-known class of privileged chiral ligands that can be incorporated with various metal ions for diversified homogeneous asymmetric organic transformations. The integration of the PyBOX into the COF platform will undoubtedly lead to a new breed of heterogeneous asymmetric catalysts. Herein, we report the first example of PyBOX-based CCOF via chiral pool synthesis for scale-up catalytic asymmetric acetalization and A 3 -coupling reaction. This research provides a novel type of sustainable COF-based heterogeneous catalyst with gratifying functionalities.}, archive = {J_ANGEW}, author = {Fei Li and Yun-Long Zhang and Han-Hui Wang and Jing-Lan Kan and Bing-Jian Yao and Yu-Bin Dong}, doi = {10.1002/anie.202505329}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505329}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PyBOX-integrated chiral covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Selective nanopore detection of monoamine oxidase a and b in a single sample. ANGEW, 64(35), e202505138. (www)

  @article{ , abstract = {Monoamine oxidases A and B (MAO-A and MAO-B) are key enzymes involved in neurotransmitter metabolism and are critical biomarkers for neurodegenerative and psychiatric disorders. Here, we present a highly sensitive nanopore-based method for the selective detection and quantification of MAO-A and MAO-B using specifically designed peptide probes. These probes undergo enzyme-specific oxidation, generating distinct nanopore translocation signatures that enable precise identification. Our method achieves picomolar-level detection, outperforming conventional assays such as ELISA. Importantly, we demonstrate its applicability in complex biological samples, including cell lysates (SH-SY5Y and HepG2) and mouse brain and liver tissues, with results strongly correlating with ELISA. The ability to selectively detect both enzymes within a single sample highlights its advantage in studying enzyme interplay in biological systems. This label-free, real-time approach offers a powerful tool for biomedical research, disease diagnostics, and drug screening, with potential for expanding to other clinically relevant enzymes.}, archive = {J_ANGEW}, author = {Xueshuang Wu and Wenying Hao and Shuaihu Yan and Ke Zhou and Lei Liu and Hai-Chen Wu}, doi = {10.1002/anie.202505138}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505138}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective nanopore detection of monoamine oxidase a and b in a single sample}, volume = {64}, year = {2025}, }
• (2025). Glycosylation-dependent stability of human pentraxin-2 revealed by surface-induced dissociation and ion mobility mass spectrometry. ANGEW, 64(35), e202505077. (www)

  @article{ , abstract = {Pentraxin-2 (PTX-2), also known as Serum Amyloid P component, functions as an immunoregulatory glycoprotein and plays a crucial role in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). Desialylation of PTX-2 has recently been associated with reduced bioactivity and diminished inhibition of fibrocyte differentiation in IPF patients. Each monomer in the naturally assembled pentameric complex is N-glycosylated, predominantly featuring terminal sialic acids on biantennary glycans. However, the influence of these glycoforms on PTX-2′s mechanism of action (MoA) and conformational properties has not been comprehensively investigated. In this study, we demonstrate the combined application of surface-induced dissociation (SID) and ion-mobility mass spectrometry (IM-MS) to assess the impact of specific glyco-engineered PTX-2 variants on the stability of its pentameric and decameric complexes. We further explore the effect of individual monomer glycosylation on complex stability. Our results reveal that high levels of terminal sialylation significantly enhance complex stability, whereas desialylation and mannosylation reduce the stability of both pentameric and decameric PTX-2 forms. Regarding the stability of single PTX-2 monomers ejected from the pentamer, in contrast, we found that desialylated and highly mannosylated glycans contribute to the individual monomer stability.}, archive = {J_ANGEW}, author = {Philipp Bittner and Felix Kuhne and Adam Pruška and Julian A. Harrison and Natalie Preiss and Markus Haberger and Dietmar Reusch and Renato Zenobi}, doi = {10.1002/anie.202505077}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202505077}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Glycosylation-dependent stability of human pentraxin-2 revealed by surface-induced dissociation and ion mobility mass spectrometry}, volume = {64}, year = {2025}, }
• (2025). Merging photocatalysis with chiral lewis acid catalysis for enantioselective Hydrosilylation/Hydrogermylation of electron-deficient alkenes. ANGEW, 64(35), e202504676. (www)

  @article{ , abstract = {Organosilicon compounds demonstrate widespread applications in many fields. Transition-metal-catalyzed asymmetric hydrosilylation represents one of the most common and effective methods to synthesize chiral organosilicon compounds, but it largely relies on electron-rich alkenes and structurally specific hydrosilanes. Visible light photocatalysis has emerged as a promising new platform for hydrosilylation. However, the enantiocontrol of photoinduced asymmetric hydrosilylation concerning highly reactive radical species is a great challenge. Herein, we report a synergistic catalytic strategy for enantioselective hydrosilylation of electron-deficient alkenes by merging anthraquinone as a dual-tasked photocatalyst with a chiral Lewis acid catalyst. This protocol shows broad hydrosilane scope with efficient chemo-, regio- and enantioselectivities, delivering diverse enantioenriched organosilicon compounds, which could be readily converted into a series of medicine molecules. Mechanistic studies reveal that the π–π interaction between the photocatalyst and the alkene is crucial for enantiocontrol. Additionally, enantioselective radical hydrogermylation was also achieved under the visible light photoinduced synergistic catalysis.}, archive = {J_ANGEW}, author = {Xiaofan Chen and Yuqiao Zhou and Ming Yang and Yuntian Yang and Xiaoming Feng and Weidi Cao}, doi = {10.1002/anie.202504676}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202504676}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Merging photocatalysis with chiral lewis acid catalysis for enantioselective Hydrosilylation/Hydrogermylation of electron-deficient alkenes}, volume = {64}, year = {2025}, }
• (2025). Unveiling the power of dark state photocages: An efficient pathway to triplet state under near-infrared light irradiation. ANGEW, 64(35), e202504670. (www)

  @article{ , abstract = {The photocage platform provides a synergistic approach to photodynamic therapy (PDT) and chemotherapy. Before light activation, both pro-photosensitizers and pro-drugs remain inert, ensuring safety. Upon near-infrared (NIR) light irradiation, they undergo photoactivation and controlled release in deep tissues. However, the low photolysis efficiency of conventional singlet-state photocages limits their in vivo applications, necessitating an exploration of how excited-state dynamics influence photolysis. In this study, we introduce the concept of a “dark state photocage” and establish a photocage platform responsive to NIR light by incorporating phenoxazine or phenothiazine groups. Mechanistic investigations reveal that the dark state enhances triplet-state formation and facilitates intersystem crossing, thereby promoting photolysis. These photocages achieve functional molecule release under low-power NIR light (15 mW cm⁻ 2 ), with an efficiency of up to 90%. This advancement enables a sharp transition from an “OFF” to an “ON” tumor imaging signal and significantly enhances the therapeutic efficacy against triple-negative breast cancer under NIR light irradiation, effectively integrating PDT and chemotherapy.}, archive = {J_ANGEW}, author = {Qiao Hu and Jianjun Du and Syed Ali Abbas Abedi and Xiaogang Liu and Saran Long and Wen Sun and Jiangli Fan and Xiaojun Peng}, doi = {10.1002/anie.202504670}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202504670}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the power of dark state photocages: An efficient pathway to triplet state under near-infrared light irradiation}, volume = {64}, year = {2025}, }
• (2025). Ru single atoms anchored in metal borides enable hydrogen spillover for superior electrochemical ammonia production. ANGEW, 64(35), e202504568. (www)

  @article{ , abstract = {The electrochemical reduction of nitrate represents a promising and sustainable route for valuable ammonia generation. However, a vital challenge in the nitrate reduction reaction is an insufficient supply of active hydrogen ( * H) and slow kinetics at a low working potential, which result in low production efficiency and high energy consumption. Here, we report the single-atom Ru-decorated nanoporous metal borides as a high-performance electrochemical nitrate reduction electrocatalyst utilizing an atomic-scale hydrogen spillover effect. Notably, the Ru SA /np-Ni 3 B exhibits a high NH 3 Faradaic efficiency of 96.2%, an NH 3 yield of 30.4 mg h −1 mg −1 , and an energy efficiency of 39.1% at −0.1 V versus RHE. In situ electrochemical characterizations and theoretical calculations reveal that single-atom Ru anchored in nanoporous Ni 3 B not only can efficiently dissociate water into * H and simultaneously promote the * H spillover for increasing * H coverage on the surface but also can optimize surface states of Ni 3 B active centers, which synergistically reduces the hydrogenation energy barrier for converting nitrate into valuable ammonia products. A two-electrode electrolyzer integrating nitrate reduction reaction with furfuryl alcohol oxidation reaction achieves current density of 1 A cm −2 at −1.72 V with 100 h stability, improving the energy efficiency and economy of the system.}, archive = {J_ANGEW}, author = {Yuanguo Chen and Haoyun Bai and Jiao Lan and Cheng-Wei Kao and Feng Xie and Linghu Meng and Jilong Li and Ying-Rui Lu and Ming Peng and Hui Pan and Yongwen Tan}, doi = {10.1002/anie.202504568}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202504568}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ru single atoms anchored in metal borides enable hydrogen spillover for superior electrochemical ammonia production}, volume = {64}, year = {2025}, }
• (2025). A phenomenological symmetry rule for chemical reactivity under vibrational strong coupling. ANGEW, 64(35), e202503915. (www)

  @article{ , abstract = {Symmetry is known to strongly influence the course of a chemical reaction. It has also been found to play a key role in vibrational strong coupling (VSC), where it can influence the outcome of chemical reactions or alter chemical equilibria. However, the precise nature of this effect and its extent remains elusive. To further explore the role of vibrational symmetry, we have investigated the equilibrium constants of different charge transfer complexes, in particular of isomers of trimethyl benzene belonging to different point groups from which a general symmetry rule emerges. We describe the strongly coupled system by a direct product of irreducible representations associated with the complexes and the cavity. As a consequence, the coupled vibration is associated with a new irreducible representation that projects differently on the reaction coordinate of the charge transfer complexation, reflecting the changes in the equilibrium constants. This phenomenological symmetry rule points to a general underlying framework for predicting the outcome of chemical reactivity under VSC.}, archive = {J_ANGEW}, author = {A. Jayachandran and B. Patrahau and J. G. Ricca and M. K. Mahato and Y. Pang and K. Nagarajan and A. Thomas and C. Genet and T. W. Ebbesen}, doi = {10.1002/anie.202503915}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202503915}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A phenomenological symmetry rule for chemical reactivity under vibrational strong coupling}, volume = {64}, year = {2025}, }
• (2025). NiH-catalyzed enantio- and regioselective hydroarylation of unactivated alkenes enabled by outer-sphere electron transfer with diaryliodonium salts. ANGEW, 64(35), e202503908. (www)

  @article{ , abstract = {Asymmetric hydroarylation of unactivated alkenes provides a direct route to enantiomerically enriched C─C bonds in aryl-containing compounds, a key transformation in pharmaceutical and natural product synthesis. While recent advances have achieved high regio- and enantioselectivity with terminal alkenes, controlled hydroarylation of unactivated internal alkenes remains challenging. Here, we report a nickel-hydride-catalyzed protocol that overcomes this limitation through a mechanistic paradigm shift. By employing diaryliodonium salts as dual-function reagents, our method achieves high enantio- and regioselectivity in the hydroarylation of both internal and terminal unactivated alkenes. These salts enable a transition from concerted to stepwise oxidative addition via dissociative single-electron transfer (DSET), generating a cationic alkyl-nickel intermediate prone to fragmentation and aryl radical addition. Mechanistic studies, including a key experiment in 1,4-dioxane yielding an enantiomerically pure solvent-functionalized product, establish migratory insertion as the enantio- and regio-determining step. This approach not only expands the scope of asymmetric hydroarylation but also provides a new mechanistic framework for selective hydrofunctionalization reactions.}, archive = {J_ANGEW}, author = {Hyung-Joon Kang and Leejae Kim and Juyeon Lee and Sungwoo Hong}, doi = {10.1002/anie.202503908}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202503908}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NiH-catalyzed enantio- and regioselective hydroarylation of unactivated alkenes enabled by outer-sphere electron transfer with diaryliodonium salts}, volume = {64}, year = {2025}, }
• (2025). Topochemical polymerization of retro-isomeric peptides for tuning the polymer structure and properties. ANGEW, 64(35), e202503624. (www)

  @article{ , abstract = {Peptidomimetic polymers containing hydrophobic amino acids and nonpeptidic linkages are interesting for various applications, particularly hydrophobic coatings. We synthesized two retro-isomeric peptide monomers decorated with azide and alkyne, viz . N 3 -L-Phe-L-Val-NHCH 2 CCH ( M1 ) and its retro-isomer N 3 -L-Val-L-Phe-NHCH 2 CCH ( M2 ), for topochemical azide–alkyne cycloaddition (TAAC) polymerization. On heating the crystals at 100 °C, both monomers underwent TAAC polymerization, yielding isomeric “difficult peptide” polymer mimics. The monomers showed stark differences in reactivity and regiochemistry of the product formed. Monomer M1 yielded polymer P1 having a 1:1 ratio of 1,4- and 1,5-triazolyl-linkages, and monomer M2 reacted regiospecifically, giving 1,4-triazolyl-linked polymer P2 . We investigated the hydrophobicity of these isomeric polymers by measuring water contact angles (WCA) of surfaces coated with these polymers; P1 and P2 showed WCA of 120° and 132°, respectively. Our study demonstrates that sequence reversal is a novel approach for accessing structurally and functionally different polymers via topochemical polymerization.}, archive = {J_ANGEW}, author = {Anu Lal and Rishika Rai and Mithun C. Madhusudhanan and Kana M. Sureshan}, doi = {10.1002/anie.202503624}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202503624}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topochemical polymerization of retro-isomeric peptides for tuning the polymer structure and properties}, volume = {64}, year = {2025}, }
• (2025). Photosensitizer repositioning affords an enantiocomplementary enzyme for [2 + 2]-cycloadditions. ANGEW, 64(35), e202503576. (www)

  @article{ , abstract = {The combination of genetic code expansion and directed evolution has recently given rise to enantioselective photoenzymes for [2 + 2]-cycloadditions of quinolone and indole derivatives. However, the enzymes reported to date only allow access to one enantiomeric series of the strained cyclobutane products. Here, guided by a crystal structure of our previously engineered enzyme EnT1.3, we show how judicious repositioning of the genetically programmed benzophenone photosensitizer affords an enantiocomplementary [2 + 2]-cyclase, CEnT1.0. Following directed evolution, a proficient and oxygen-tolerant photoenzyme (CEnT1.4) emerged that promotes [2 + 2]-cycloadditions of a quinolone derivative with exquisite enantiocontrol (99% e.e .) and substantially enhanced regioselectivity compared with EnT1.3 (r.r. 62:1 vs. 9:1). Structural analysis of CEnT1.4, coupled with molecular dynamic simulations, reveals a well-sculpted active site pocket that pre-organises the substrate for regio- and enantioselective catalysis. This study highlights the versatility offered by genetically programmed (photo)catalytic elements when developing enzymes for altered stereochemical outcomes.}, archive = {J_ANGEW}, author = {Chuanjie Sun and Anna R. Kohn and Ross Smithson and Florence J. Hardy and Jonathan S. Trimble and Yuanxin Cao and Linus O. Johannissen and Sam Hay and Rebecca Crawshaw and Anthony P. Green}, doi = {10.1002/anie.202503576}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202503576}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photosensitizer repositioning affords an enantiocomplementary enzyme for [2 + 2]-cycloadditions}, volume = {64}, year = {2025}, }
• (2025). Efficient red Light–Driven singlet oxygen photocatalysis with an osmium-based coulombic dyad. ANGEW, 64(35), e202502840. (www)

  @article{ , abstract = {Photoactive osmium complexes are widely used sensitizers for the generation of singlet oxygen because they can be excited directly into their triplet states with low-energy red light. However, their short-lived excited states reduce quenching efficiencies and reaction quantum yields significantly. To elongate the excited state lifetime, osmium complexes have been linked to organic chromophores to form molecular dyads. This approach, although effective, is time- and resource-consuming, hampering larger-scale applications. Here, we demonstrate a straightforward approach by directly mixing a readily available cationic osmium complex and an anionic perylene derivative in solution. Strong Coulombic interactions facilitate rapid energy transfer (∼100 ps) from the excited osmium complex to the perylene derivative, mimicking a dyad-like system. Detailed spectroscopic investigations revealed an increased singlet oxygen formation rate by over one order of magnitude at sub-millimolar perylene concentrations, attributed to i) the three orders of magnitude longer lifetime of the perylene triplet state produced via intra-ion-pair energy transfer and ii) an inherently high singlet oxygen quantum yield of that key species. The novel catalyst system enables highly productive photooxygenations in water and in a MeOH/H 2 O 10:1 mixture, highlighting the broad applicability and versatility of the Coulombic dyad approach for photocatalytic synthesis and wastewater treatment.}, archive = {J_ANGEW}, author = {Matthias Schmitz and Robert Naumann and Katja Heinze and Christoph Kerzig}, doi = {10.1002/anie.202502840}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202502840}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient red Light–Driven singlet oxygen photocatalysis with an osmium-based coulombic dyad}, volume = {64}, year = {2025}, }
• (2025). Precision photochemistry: Every photon counts. ANGEW, 64(35), e202502651. (www)

  @article{ , abstract = {Photochemistry is undergoing a precision transformation. Through technological advancements, such as the advent of light emitting diodes and monochromatic lasers, chemists are now able to use photons not only as an energy source but also as a tool for directing photochemical processes with both wavelength and spatiotemporal precision. Enabled by these technologies, the discovery that photochemical action often does not align with molar extinction has catalysed the growth of the research field that we coin Precision Photochemistry . We explain how precision photochemistry stands on four fundamental pillars: molar extinction, wavelength-dependent quantum yield, concentration of the chromophores, and the length of the irradiation. Each of these four pillars are intrinsically linked and dictate the experimental conditions that should be used (e.g., wavelength, light intensity, and solvent system), as we demonstrate through simulations of a photochemical uncaging system. Building on these pillars, we propose a concrete definition for Precision Photochemistry and highlight important fields within chemistry that will benefit from careful consideration of them. Finally, we address key experimental considerations that must be taken into account when conducting precision photochemistry including the light source, the reaction setup, and the method for determining (wavelength-dependent) quantum yields. These factors are critical in furthering the development of the field of Precision Photochemistry .}, archive = {J_ANGEW}, author = {Fred Pashley-Johnson and Xingyu Wu and Joshua A. Carroll and Sarah L. Walden and Hendrik Frisch and Andreas-Neil Unterreiner and Filip E. Du Prez and Hans-Achim Wagenknecht and Javier Read de Alaniz and Ben L. Feringa and Alexander Heckel and Christopher Barner-Kowollik}, doi = {10.1002/anie.202502651}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202502651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precision photochemistry: Every photon counts}, volume = {64}, year = {2025}, }
• (2025). The chemistry and biology of the tetrodotoxin natural product family. ANGEW, 64(35), e202502404. (www)

  @article{ , abstract = {Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity. This review highlights the diversity of the tetrodotoxin natural product family and discusses the origins of derivatives, biosynthetic hypotheses, and biological activities. Furthermore, potential therapeutic applications and structure–activity relationship studies are covered, along with the total syntheses of the natural product and selected derivatives that were published to date.}, archive = {J_ANGEW}, author = {Benedikt Nißl and Marcel Mülbaier and Francesca Grisoni and Dirk Trauner and Marcel Bermúdez and Clemens Dialer and David B. Konrad}, doi = {10.1002/anie.202502404}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202502404}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The chemistry and biology of the tetrodotoxin natural product family}, volume = {64}, year = {2025}, }
• (2025). Microscale tattooing of hydrogels and cells: Benzoxaborole-driven microcontact printing (µCP) on glycosylated surfaces. ANGEW, 64(35), e202501759. (www)

  @article{ , abstract = {Microcontact printing (µCP) is a widely used technique for microscale surface patterning. In this study, we present a polymer-supported µCP method for the patterning of (bioactive) glycosylated surfaces under hydrated conditions. Patterning is achieved by direct contact with a grooved polydimethylsiloxane (PDMS) stamp, whose surface was grafted with a dopamine-containing polymer. The polymer brushes offer an anchor for the boronic acid derivative 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol (ABOB), used as an ink for surface functionalization, to introduce patterns to three different surfaces as substrates: (1) monosaccharide-modified hydrogel surfaces possessing aldose (glucose, fucose, galactose) or ketose (fructose, sorbose) functions; (2) glycosylated surfaces of polymeric microspheres; and (3) the membranes of mammalian cells, such as human primary gastric cells and others. During µCP, ABOB patterns transferred to the target surface through the formation of carbohydrate-ABOB complexes at fully hydrated, neutral pH conditions. Fluorescence microscopy confirmed the successful transfer of ABOB patterns to glycosylated surfaces, with clear “tattoo-like” signatures observed on hydrogels, glycosylated particle surfaces and cellular interfaces.}, archive = {J_ANGEW}, author = {Nazim Pallab and Eric Sperlich and Matthias Schenderlein and Anne Krüger-Genge and Jinyuan Li and Lukas Zeininger and Zdeněk Tošner and Mariusz Uchman and Martin Reifarth}, doi = {10.1002/anie.202501759}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202501759}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Microscale tattooing of hydrogels and cells: Benzoxaborole-driven microcontact printing (µCP) on glycosylated surfaces}, volume = {64}, year = {2025}, }
• (2025). Scalable hyperpolarized MRI enabled by ace-SABRE of [1-13C]Pyruvate. ANGEW, 64(35), e202501231. (www)

  @article{ , abstract = {Hyperpolarized (HP) MRI using [1– 13 C]pyruvate is emerging as a promising molecular imaging approach. Among hyperpolarization methods, Signal Amplification By Reversible Exchange (SABRE) is attractive because SABRE polarizes the substrates directly in room-temperature solutions avoiding complex hardware. Most SABRE experiments have historically been performed in methanol, a relatively toxic and difficult-to-remove solvent. Here we demonstrate the use of a 80/20 acetone/water (A/W) solvent system (Ace-SABRE) to provide hyperpolarized [1– 13 C]pyruvate with up to 17% polarization, then implement a solvent processing protocol to achieve injectable solutions retaining 74% of the initial polarization, and lastly we demonstrate HP in vivo spectroscopy and imaging using the Ace-SABRE platform to showcase metabolic tracking in a hepatocellular carcinoma (HCC) tumor as well as HP-MRI, both in direct comparison to dissolution dynamic nuclear polarization (d-DNP) experiments. The Ace-SABRE technique promises faster adoption of SABRE hyperpolarization in biological experiments, overall lowering the barriers to entry for HP-NMR and HP-MRI.}, archive = {J_ANGEW}, author = {Stephen J. McBride and Megan Pike and Erica Curran and Alexander Zavriyev and Bukola Adebesin and Luke Tucker and Jared M. Harzan and Ishani M. Senanayake and Mustapha Abdulmojeed and Franziska Theiss and Sheng Shen and Thomas Boele and Simon B. Duckett and Boyd M. Goodson and Matthew S. Rosen and Eduard Y. Chekmenev and Hong Yuan and Carlos Dedesma and Terence Gade and Stephen Kadlecek and Thomas Theis and Patrick TomHon}, doi = {10.1002/anie.202501231}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202501231}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable hyperpolarized MRI enabled by ace-SABRE of [1-13C]Pyruvate}, volume = {64}, year = {2025}, }
• (2025). Bulk- and surface-engineered carbon nitride with promoted electron transfer for NADH regeneration and artificial photosynthesis. ANGEW, 64(35), e202424995. (www)

  @article{ , abstract = {Carbon nitride (CN), a well-known photocatalyst, has been extensively utilized in light-driven redox reactions, including NADH regeneration. However, its catalytic efficiency is hindered by rapid charge recombination due to obstructed electron transfer. Herein, we developed a highly porous CN coated with a thin layer of rhodium complex (Rh*-PCN) through a combination of bulk and surface engineering for enhanced NADH regeneration. The bulk-engineered porous network of PCN facilitates oriented electron transfer in Rh*-PCN, while the surface-engineered Rh layer minimizes the electron transfer distance between PCN and the rhodium complex. Rh*-PCN achieves an initial NADH regeneration rate of 16.80 mmol g⁻¹ h⁻¹. Moreover, Rh*-PCN suppresses enzyme deactivation by compartmentalizing the enzyme from the photogenerated holes on PCN and the rhodium complex. When integrated with glutamate dehydrogenase, the Rh*-PCN/enzyme coupled system produces L-glutamic acid.}, archive = {J_ANGEW}, author = {Chen Tao and Zhuo Wang and Yexin Dai and Shaohua Zhang and Jing Li and Yu Chen and Xinyu Mao and Jiafu Shi and Zhongyi Jiang}, doi = {10.1002/anie.202424995}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202424995}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bulk- and surface-engineered carbon nitride with promoted electron transfer for NADH regeneration and artificial photosynthesis}, volume = {64}, year = {2025}, }
• (2025). Exploring excited state proton transfer in thin films under vibrational strong coupling. ANGEW, 64(35), e202424247. (www)

  @article{ , abstract = {Molecular structure, solvent/matrix, the surrounding environment, and molecular vibrations can influence the excited-state proton transfer (ESPT) process. Theoretical studies predict that light-matter strong coupling can modify the energy barrier for proton transfer reactions. Here, we experimentally explore the role of vibrational strong coupling (VSC) on the ESPT using the weak photoacid, 7-hydroxy-1-naphthalenesulfonate (N8S) as the probe. The ESPT in N8S can occur through a solvent/matrix bridge connecting the proton-donating and accepting units. To check the role of VSC, we embedded N8S in a poly(vinyl alcohol) (PVA) matrix and strongly coupled the ─OH stretching vibrational modes of PVA. The steady-state and time-resolved emission analysis reveal that the quantum yield of RO − emission and the ESPT rate constant enhance by a factor of two under VSC, compared to the noncavity, half-cavity, and off-resonance films. Our findings indicate that VSC can be a tool to control the proton transfer processes, opening avenues for developing physically tunable photoacid-based sensors.}, archive = {J_ANGEW}, author = {Malay Krishna Mahato and Kavya S. Mony and Harsh Baliyan and Subha Biswas and Anoop Thomas}, doi = {10.1002/anie.202424247}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202424247}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploring excited state proton transfer in thin films under vibrational strong coupling}, volume = {64}, year = {2025}, }
• (2025). Unveiling the influence of cyanogen vacancies in prussian blue for sodium-ion batteries. ANGEW, 64(35), e202421916. (www)

  @article{ , abstract = {Prussian blue (PB), recognized as a promising cathode material, has gained significant attention for sodium-ion batteries due to its high theoretical energy density, low cost, and ease of synthesis. However, the influence of anion vacancies on the stability of the PB framework remains controversial, impeding a comprehensive grasp of their precise role in electrochemical performance and the controlled synthesis of PB with smaller anionic vacancies remains challenging due to the limitations inherent in current synthesis strategies. Herein, we present an anion complexation method to synthesize PB materials with tunable cyanide vacancy concentrations. Furthermore, we propose a vacancy-driven mechanism that promotes spin transitions coupled with lattice bending, which are more reversible at low-spin Fe sites, leading to excellent low-spin stability and the design of materials with outstanding electrochemical performance. This anion complexation method not only provides a novel synthetic pathway for PB materials but also advances the understanding of the composition-structure-property relationships between cyanide vacancy configurations and spin transition mechanism, highlighting its potential for future energy storage applications.}, archive = {J_ANGEW}, author = {Xiang Gao and Longlong Guo and Shangjun Zhang and Haoquan Li and Nuo Chen and Yuehang Han and Bohui He and Peiying Ma and Wensheng Gao and Yongxiao Bai}, doi = {10.1002/anie.202421916}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202421916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the influence of cyanogen vacancies in prussian blue for sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Superprotonic conduction over wide humidity range driven by enhanced proton dissociation. ANGEW, 64(35), e202421444. (www)

  @article{ , abstract = {Proton-conducting materials play a key role in various fields, and their proton conduction is profoundly restricted by the proton dissociation process. This process has two components: dissociation from acidic groups (e.g., −SO 3 H) and dissociation from intermediate species (e.g., H 3 O + , C─F···H + ). Extensive research has concentrated on the former, utilizing acidic groups with minimal proton dissociation energy or low pKa values, while the latter's substantial effects have been largely overlooked. In reality, proton-accepting atoms within intermediates, such as oxygen and nitrogen, typically produce a higher electron cloud density compared to those in acidic groups. This results in a pronounced electrostatic binding effect on mobile protons, as well as high dissociation energies. Thus, diminishing the dissociation energy associated with intermediates is paramount in the development of high-performance proton conductors. Herein, we construct one covalent organic framework-based proton conductor, achieving superprotonic conduction over a wide humidity range by decreasing the dissociation energy of protons from intermediates. The success of this approach can be attributed to two key factors: the crowded guest molecules within the framework that mitigate proton hydration, and the concurrent establishment of C─H···H + interactions. These combined effects significantly reduce the electrostatic attraction exerted on mobile protons, thereby enhancing proton conduction.}, archive = {J_ANGEW}, author = {Kun Zhang and Lei Wu and Ke Gong and Shuyang Bian and Yanting Zhang and Huayu Gu and Dongshuang Wu and Linfeng Hu and Huiyuan Liu and Yusong Wang}, doi = {10.1002/anie.202421444}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {35}, pages = {e202421444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Superprotonic conduction over wide humidity range driven by enhanced proton dissociation}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Regiodivergent photocatalytic annulation for the synthesis of gem-difluorinated cyclic hydrocarbons. ANGEW, 64(34), e202583401. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583401}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202583401}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Regiodivergent photocatalytic annulation for the synthesis of gem-difluorinated cyclic hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: AM-DMF-ddRPA: An all-in-one digital microfluidic platform for rapid and automatic digital nucleic acid analysis (Angew. chem. int. ed. 34/2025). ANGEW, 64(34), e202516112. (www)

  @article{ , archive = {J_ANGEW}, author = {Jiajian Ji and Xinpei Pang and Chunyu Chang and Dongping Wang and Siyi Hu and Zhixin Fang and Chao Yu and Qian Mei and Hanbin Ma}, doi = {10.1002/anie.202516112}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202516112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: AM-DMF-ddRPA: An all-in-one digital microfluidic platform for rapid and automatic digital nucleic acid analysis (Angew. chem. int. ed. 34/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Intracellular delivery of native proteins by BioReversible arginine modification (BioRAM) on amino groups (Angew. chem. int. ed. 34/2025). ANGEW, 64(34), e202515542. (www)

  @article{ , archive = {J_ANGEW}, author = {Jonathan Franke and Jan Vincent V. Arafiles and Christian Leis and Christian P. R. Hackenberger}, doi = {10.1002/anie.202515542}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202515542}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Intracellular delivery of native proteins by BioReversible arginine modification (BioRAM) on amino groups (Angew. chem. int. ed. 34/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Exploring mesoionic imine-carbodiimide (MII-CDI) adducts: 1,3 H-shift, N(I) compounds and guanidinate-type ligands (Angew. chem. int. ed. 34/2025). ANGEW, 64(34), e202515318. (www)

  @article{ , archive = {J_ANGEW}, author = {Alok Mahata and Richard Rudolf and Robert R. M. Walter and Nicolás. I. Neuman and Biprajit Sarkar}, doi = {10.1002/anie.202515318}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202515318}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Exploring mesoionic imine-carbodiimide (MII-CDI) adducts: 1,3 H-shift, N(I) compounds and guanidinate-type ligands (Angew. chem. int. ed. 34/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: A butterfly-like fluorescent tracker for dynamic polymers (Angew. chem. int. ed. 34/2025). ANGEW, 64(34), e202515308. (www)

  @article{ , archive = {J_ANGEW}, author = {Shudong Zheng and Minyi Ma and Da-Hui Qu and He Tian and Qi Zhang}, doi = {10.1002/anie.202515308}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202515308}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: A butterfly-like fluorescent tracker for dynamic polymers (Angew. chem. int. ed. 34/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Cell-active, arginine-targeting irreversible covalent inhibitors for nonkinases and kinases”. ANGEW, 64(34), e202515279. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202515279}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202515279}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Cell-active, arginine-targeting irreversible covalent inhibitors for nonkinases and kinases”}, volume = {64}, year = {2025}, }
• (2025). Frank tambornino. ANGEW, 64(34), e202514406. (www)

  @article{ , archive = {J_ANGEW}, author = {Frank Tambornino}, doi = {10.1002/anie.202514406}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202514406}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frank tambornino}, volume = {64}, year = {2025}, }
• (2025). Tynchtyk amatov. ANGEW, 64(34), e202514106. (www)

  @article{ , archive = {J_ANGEW}, author = {Tynchtyk Amatov}, doi = {10.1002/anie.202514106}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202514106}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tynchtyk amatov}, volume = {64}, year = {2025}, }
• (2025). Synthesis of a linear tetraboron cation via deprotonation of a nonsupported dimeric hydroborylborenium ion. ANGEW, 64(34), e202512223. (www)

  @article{ , abstract = {The nonsupported B–H–B moiety of a dimeric hydroborylborenium ion can be readily deprotonated by 4-(dimethylamino)pyridine, affording a H-bridged linear tetraboron cation. The resulting tetraboron cation shows diverse reactivity with small molecules. Treatment of this tetraboron cation with H 2 leads to the first example of complete hydrogenolysis of main-group homocatenated chains. On the other hand, in the presence of t BuNC, only the internal B–B bond of the tetraboron cation is cleaved, resulting in the formation of an azadiborabutadiene cation. Additionally, during the preparation of the hydroborylborenium, an unprecedented formal boryl cage-walking was observed. Experimental and theoretical studies suggest this process involves consecutive activation of carboranyl B(9)–H bonds.}, archive = {J_ANGEW}, author = {Yizhao Huang and Zhen Hua Li and Huadong Wang}, doi = {10.1002/anie.202512223}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202512223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of a linear tetraboron cation via deprotonation of a nonsupported dimeric hydroborylborenium ion}, volume = {64}, year = {2025}, }
• (2025). Embracing complexity: Peptides as tunable scaffolds in the construction of discrete supramolecular systems. ANGEW, 64(34), e202512014. (www)

  @article{ , abstract = {Supramolecular chemistry has advanced rapidly, with scientists using fundamental understanding to generate function from simple building blocks. However, synthetic systems are still in their infancy when compared to biology. The increasing use of peptides in supramolecular structures provides a clear roadmap to more complex function, introducing chiral, information-rich building blocks from a readily available pool. Peptides have historically been incorporated as modular additions to discrete supramolecular architectures to interface with biological systems. More recently, supramolecular chemists have embraced the complexity of secondary and tertiary structures and peptides’ intrinsic propensity for folding to enable the formation of supramolecular architectures built from peptides, leveraging their innate properties. We explore the urgent need to embrace complex, chiral, folded building blocks in discrete supramolecular architectures and illustrate how this will provide opportunities for novel functions and applications.}, archive = {J_ANGEW}, author = {Ben E. Barber and Ellen M. G. Jamieson and Leah E. M. White and Charlie T. McTernan}, doi = {10.1002/anie.202512014}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202512014}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Embracing complexity: Peptides as tunable scaffolds in the construction of discrete supramolecular systems}, volume = {64}, year = {2025}, }
• (2025). Rational design strategies in DNA-encoded libraries for drug discovery. ANGEW, 64(34), e202511839. (www)

  @article{ , abstract = {DNA-encoded libraries (DELs) have emerged as a powerful and cost-effective platform for high-throughput screening, enabling the rapid identification of small-molecule ligands against a wide range of biological targets. However, traditional DEL approaches often rely on empirical and broad-based library construction, which can lead to low hit rates, off-target interactions, and limited chemical diversity around pharmaceutically relevant motifs. Recent technological advances have sought to address these limitations, shifting DELs from a largely blind screening tool to a more rational and precision-oriented strategy. In this review, we systematically examine the evolution of DEL methodologies, with a particular focus on innovations in library design that enhance hit quality and screening efficiency. Specifically, we highlight the emergence of fragment-based DEL strategies for exploring chemical space with minimal structures, the incorporation of covalent warheads to enable irreversible binding to specific residues, and the development of focused DELs tailored to particular protein families or binding motifs. Together, these advances mark a shift from blind, empirical screening toward a more strategic and hypothesis-driven application of DEL technology.}, archive = {J_ANGEW}, author = {Xudong Wang and Linjie Li and Xuanjing Shen and Xiaojie Lu}, doi = {10.1002/anie.202511839}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511839}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design strategies in DNA-encoded libraries for drug discovery}, volume = {64}, year = {2025}, }
• (2025). Chalcogen bonding boosts the uptake of small molecules in mammalian cells. ANGEW, 64(34), e202511786. (www)

  @article{ , abstract = {Chalcogen bonding, a noncovalent interaction between the chalcogen atom (S, Se, and Te) and Lewis base, plays crucial roles in catalysis, anion recognition, protein confirmation, enzyme activity, and drug design. Herein, we show that chalcogen bonding can be used as a driving force to enhance the uptake of small molecules in mammalian cells. A systematic investigation using several chalcogen-containing fluorescent molecules reveal that the cellular uptake strongly depends on the nature of chalcogen atom and the compounds with heavier chalcogen atoms (Se and Te), which can form stronger chalcogen bonds, are preferentially taken up by the cells. This study suggests that the biological activities of chalcogen-based compounds may depend not only on their chemical reactivity but also on their chalcogen bond forming ability with the cell membrane.}, archive = {J_ANGEW}, author = {Ekta Chauhan and Debasish Giri and Vijayakumar Govindaraj and Govindasamy Mugesh}, doi = {10.1002/anie.202511786}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chalcogen bonding boosts the uptake of small molecules in mammalian cells}, volume = {64}, year = {2025}, }
• (2025). Efficient separation of methanol-to-olefins products using a robust polycatenated hydrogen-bonded organic framework. ANGEW, 64(34), e202511773. (www)

  @article{ , abstract = {The methanol-to-olefins process produces mixtures of ethylene and propylene, driving demand for high-performance separation materials. We present HOF-ZJNU-3, a hydrogen-bonded organic framework built from an expanded BTB (4,4′,4″-benzene-1,3,5-triyl-tribenzoate) linker, featuring the highest catenation degree observed in BTB-based HOFs. This unique architecture confers good stability under solvent, pH, and thermal conditions. With optimally sized pores and aromatic-rich surfaces, HOF-ZJNU-3 demonstrates excellent propylene/ethylene separation potential, outperforming its parent frameworks (HOF-BTB and HOF-BTB-NH 2 ) under ambient conditions. Notably, the material accomplishes single-cycle purification of high-purity ethylene (99.95%) and propylene (99.5%) from equimolar binary mixtures, achieving a record ethylene productivity of 3.22 mol kg −1 among HOF adsorbents. This study not only establishes HOF-ZJNU-3 as a benchmark HOF material for MTO product separation but also advances the structural design of HOFs for industrial olefin purification.}, archive = {J_ANGEW}, author = {Shengjie Lin and Peiren Ke and Limin Wang and Ye Liang and Jianbo Hu and Lin Zhang and Zhenyi Zhang and Yabing He and Banglin Chen}, doi = {10.1002/anie.202511773}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511773}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient separation of methanol-to-olefins products using a robust polycatenated hydrogen-bonded organic framework}, volume = {64}, year = {2025}, }
• (2025). Anisotropy of single-crystal semiconductors in Photo(electro)Catalysis. ANGEW, 64(34), e202511706. (www)

  @article{ , abstract = {Anisotropy in single-crystal semiconductors has emerged as a key design principle for understanding and advancing photo(electro)catalytic systems. The exposure of well-defined facets in single-crystal semiconductors introduces anisotropic variations in atomic coordination, electronic structure, and surface energetics, giving rise to directional charge transport and facet-specific reactivity. Such intrinsic differences coordinate the entire photocatalytic process, from charge excitation and separation to interfacial reaction kinetics. In this regard, effective utilization of anisotropy requires clarifying its impact on electronic structure, charge transport, and interfacial reactivity, along with its sensitivity to microenvironmental changes under realistic operando conditions. In this review article, we systematically examine the role of crystallographic anisotropy in light harvesting, charge carrier dynamics, and surface reactivity. We summarize recent advances in anisotropic material design, trace the evolution of the concept, and provide mechanistic insights based on experimental studies, theoretical models, and advanced characterization techniques. We further discuss current challenges and propose strategies to guide the rational application of anisotropy in catalyst design, aiming to expand its scope across a broader range of photo(electro)catalytic systems.}, archive = {J_ANGEW}, author = {Peng Cheng Ding and Yang Zhang and Wen Jing Li and Zheng Ming Li and Xue Lu Wang and Peng Fei Liu and Hua Gui Yang}, doi = {10.1002/anie.202511706}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511706}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anisotropy of single-crystal semiconductors in Photo(electro)Catalysis}, volume = {64}, year = {2025}, }
• (2025). The Iron–Sulfur cluster of bacterioferritin-associated ferredoxin (Bfd): A “Biological fuse” that prevents oxidative damage to cells?. ANGEW, 64(34), e202511340. (www)

  @article{ , abstract = {Iron is in an essential micronutrient in living systems. However, it is also potentially toxic and so the concentration of chelatable iron within cells is tightly regulated to prevent catalytic formation of harmful reactive oxygen species (ROS). Ferritins play a key role in iron homeostasis by storing excess iron as an insoluble ferric mineral within the protein. When bacterial cells become iron deficient, this store may be accessed by reduction/solubilisation of the iron. Bacterioferritins utilise heme, bound at an inter-subunit site, to support electron transfer to the stored mineral. Electrons for heme reduction are shuttled from NADPH via Bfd, a [2Fe–2S] cluster-containing ferredoxin. This raises the paradox that the synthesis of an iron-dependent protein co-factor is required under conditions of iron-deficiency so that stored iron can be utilised. Here, we show that exposure of Bfd to ROS suppresses the capacity of the protein to stimulate iron release from bacterioferritin. We propose that reliance of iron release on Bfd evolved to ensure that chelatable iron levels do not increase under oxidative stress conditions. Thus, the Bfd iron–sulfur cluster functions as a “biological fuse” in providing a fail-safe that immediately halts iron release once ROS accumulate to damaging concentrations.}, archive = {J_ANGEW}, author = {Justin M. Bradley and Aiden M. Carter and Zinnia Bugg and Simon C. Andrews and Nick E. Le Brun}, doi = {10.1002/anie.202511340}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511340}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The Iron–Sulfur cluster of bacterioferritin-associated ferredoxin (Bfd): A “Biological fuse” that prevents oxidative damage to cells?}, volume = {64}, year = {2025}, }
• (2025). “Outside-in” design of single-atom catalysts: Linking specific peripheral geometry to defined CO2 reduction performance. ANGEW, 64(34), e202511184. (www)

  @article{ , abstract = {The regulation of single-atom catalyst (SAC) through microenvironment engineering, particularly via peripheral species, has recently garnered significant attention in the fields of materials science and heterogeneous catalysis. Nevertheless, establishing unambiguous structure-property relationships for SAC, especially concerning peripheral effects, remains a significant challenge. Herein, we propose a strategy for the design of N-doped carbon-supported Fe SACs for CO 2 reduction reaction (CO 2 RR). Density functional theory(DFT) calculations reveal that installing five- or six-membered ring in the outer shell modulates the electronic properties of the inner-shell coordination N species, altering their electron transfer capabilities while fine-tuning the d - p coupling between the Fe center and adjacent N atoms. Notably, five-membered rings induce stronger d - p coupling compared to their six-membered counterparts, leading to a higher Fe valence state. This electronic modulation optimizes the adsorption strength of key CO 2 RR intermediates (COOH* and CO*), enhancing catalytic performance for CO production. Extensive experimental studies corroborate these theoretical findings. The proposed “outside-in” design strategy can be extended to Ni SACs, offering new insights into the exploration of highly efficient single-atom centers through peripheral geometric effects.}, archive = {J_ANGEW}, author = {Jia Zhao and Yang Chen and Di Liu and Weng Fai Ip and Jian Lin and Xiaodong Wang and Sen Lin and Xianzhi Fu and Tao Zhang}, doi = {10.1002/anie.202511184}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511184}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Outside-in” design of single-atom catalysts: Linking specific peripheral geometry to defined CO2 reduction performance}, volume = {64}, year = {2025}, }
• (2025). Merging one- and multi-photon processes in hydrogen-bonded organic frameworks for enhanced NIR light-driven photothermal and photochemical conversions. ANGEW, 64(34), e202511088. (www)

  @article{ , abstract = {Direct application of near-infrared (NIR) light for solar-thermal and solar-chemical conversions is of emergent interest to improving efficiency in solar-energy utilization. Herein, we report a synthetic approach to NIR-responsive materials by self-assembly of hydrogen-bonded organic frameworks ( HOF-1/2/3 ) from multifunctionalized Ru-components incorporating chiral, photoactive, H-bonding, π-stacking, and protonation/deprotonation subunits. Significantly, protonation of the imidazole-subunits in HOF-3 promotes densified packing to extend NIR absorption tail up to 1100 nm with a narrowed bandgap of 1.41 eV, meanwhile leads to spontaneous resolution of enantiomeric Δ-/Λ-HOF-3 . Consequently, remarkably enhanced photothermal effect and photocatalytic performance, including chiroptical activity induced by circularly polarized NIR light, are achieved through synergy of direct one- and multi-photon NIR absorption, underscoring effectiveness to bring multifunctionalities into ordered HOFs for generation of robust and effective materials with multimode NIR responsiveness.}, archive = {J_ANGEW}, author = {Chen-Hui Liu and Zhong-Hao Wang and Yin-Hui Huang and Yu-Lin Lu and Shao-Ping Zheng and Xiao-Dong Zhang and Kai Wu and Cheng-Xia Chen and Hai-Sen Xu and Mei Pan and Cheng-Yong Su}, doi = {10.1002/anie.202511088}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511088}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Merging one- and multi-photon processes in hydrogen-bonded organic frameworks for enhanced NIR light-driven photothermal and photochemical conversions}, volume = {64}, year = {2025}, }
• (2025). Improving mass transport and charge transfer in COF-based photocatalysts with three-dimensional ordered macropores for benzylamine oxidation and hydrogen evolution. ANGEW, 64(34), e202511080. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have shown promise as photocatalysts for chemical transformations. However, their dense micropores and poor pore connectivity hinder mass transport and charge separation/transfer, limiting their efficiency. Herein, we develop a one-step self-sacrificing template strategy to synthesize three-dimensional ordered macroporous COFs (3DOM-COFs). This approach uniquely integrates in situ Tp–Tta COF crystallization with synchronized degradation of polystyrene templates under solvothermal conditions. This method introduces unreported kinetic match between template decomposition and framework growth. Such a confined growth mechanism leads to structurally robust and highly ordered macroporosity without post-processing. 3DOM architecture enables uniform dispersion of fine ZnCdS nanoparticles for the generation a 3DOM-COF based S-scheme heterojunction, which exhibits remarkable performance in the oxidation of benzylamine (BA) for simultaneous N-benzylbenzaldimine production with 99% selectivity at a rate of 15.1 mmol g −1 h −1 and H 2 generation with a rate of 17.8 mmol g −1 h −1 . The 3DOM architecture confers 50-fold faster mass transport than bulk COFs, while the heterojunction facilitates directional charge separation and interface charge transfer. Density functional theory calculations confirm that the heterojunction optimizes reaction thermodynamics by lowering the potential energy barriers of BA activation. The work pioneers a template-concurrent synthesis paradigm, resolving COFs' critical pore engineering challenges.}, archive = {J_ANGEW}, author = {Lijuan Sun and Weicheng Yan and Weikang Wang and LeLe Wang and Silvio Osella and Guijie Liang and William A. Goddard and Radek Zbořil and Yazhou Zhou and Juan Yang and Qinqin Liu}, doi = {10.1002/anie.202511080}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202511080}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving mass transport and charge transfer in COF-based photocatalysts with three-dimensional ordered macropores for benzylamine oxidation and hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). A polyaromatic metallotube with a dual multi-functionalization ability. ANGEW, 64(34), e202510929. (www)

  @article{ , abstract = {Post-functionalization is an advanced, key synthetic method in supramolecular systems, whereas the previous method relies heavily on the substitution on the organic frameworks. Here we report a polyaromatic metallotube capable of dually multi-functionalizing the metal sites in an efficient post-assembly fashion. The Pt(II)-linked tube with tetrachloro groups is prepared from two PtCl 2 hinges and two bent bispyridine ligands in high yield. The new metallotube efficiently converts to tetra-substituted tubes by the first multiple functionalization, through the replacement of the chloro groups with various alkynyl groups. The tubular structures before/after the functionalization are unequivocally confirmed by X-ray crystallographic analysis. A resultant tetraammonium-attached Pt(II)-tube exhibits high water solubility and uptake abilities toward spherical and rod-like compounds. The metallotube strongly binds one molecule of fullerene C 60 in the polyaromatic cavity yet releases it through the second multi-functionalization by tetrabromination of the metal hinges in a quantitative and reversible manner. Even after Bingel reaction within the tube, sterically demanding bis-substituted fullerenes (>∼80% selectivity) are readily released by the second functionalization. The present method, i.e., the use of simple PtCl 2 hinges, will be applicable to wide-ranging metallo-supramolecules to enhance their structural and functional versatilities via post-multi-functionalizations.}, archive = {J_ANGEW}, author = {Koki Tagai and Yuya Tanaka and Michio Yamada and Michito Yoshizawa}, doi = {10.1002/anie.202510929}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510929}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A polyaromatic metallotube with a dual multi-functionalization ability}, volume = {64}, year = {2025}, }
• (2025). Coherently coupled frustrated lewis pairs in In2O3−x nanoclusters for selective CO2 photoreduction to CH4. ANGEW, 64(34), e202510799. (www)

  @article{ , abstract = {Co-catalysts integration presents unique opportunities to enhance photoactivity, yet selectivity control and mechanistic understanding within multistep reactions remain fundamental challenges hitherto. In this study, a reshaped kinetic landscape is demonstrated over coherently coupled surface frustrated Lewis pairs (FLPs) on carbon nitride matrix, which mediates directed CO 2 -to-CH 4 conversion with a selectivity of 65.3% (electron basis). The hydrogen-bonded interface fosters intimate electronic coupling, generating built-in electric fields that facilitate cascade charge transfer processes. Particularly, exceptionally robust FLPs sites were identified within the sub-nanosized In 2 O 3− x nanoclusters, in contrast to easily deactivated counterparts in oversized crystalline structures. These enduring FLPs sites confer privileged adaptive binding with CO 2 and mutative C1 intermediates. Correlated in situ infrared and mass spectroscopic analyses track the formation of FLPs-CO 2 adducts and highlight the predominance of formate (HCOO − ) pathway, surpassing competitive CO evolution. This work opens inspiring prospects for exploring multielectron photochemistry and achievable metrics through distinctive FLPs topologies on sub-nanostructures.}, archive = {J_ANGEW}, author = {Wenzhe Shang and Yuehui Li and Wei Che and Tianna Liu and Wentao Peng and Jingya Guo and Wenjun Fan and Jong-Beom Baek and Jungang Hou and Wei Liu and Yantao Shi}, doi = {10.1002/anie.202510799}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510799}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coherently coupled frustrated lewis pairs in In2O3−x nanoclusters for selective CO2 photoreduction to CH4}, volume = {64}, year = {2025}, }
• (2025). Transforming single-atom site to dual-atom site in Fe–N–C catalysts: A universal strategy for enhancing durability in proton-exchange membrane fuel cells. ANGEW, 64(34), e202510671. (www)

  @article{ , abstract = {Fe–N–C catalyst is the most promising non-noble metal oxygen reduction catalyst for proton-exchange membrane fuel cells (PEMFCs); however, their practical applications are still limited by unsatisfactory long-term stability. This is because the N atoms of the active FeN 4 moiety are easy to protonate, leading to the leaching of Fe atoms, and the H 2 O 2 generated during oxygen reduction reaction (ORR) process triggers the Fenton reaction, further accelerating the dissolution of Fe. To address these critical stability challenge, we developed a general strategy to transform FeN 4 single-atom sites to Fe 2 N 6 dual-atom sites in Fe–N–C catalysts with various carbon substrates. This is achieved by treating the presynthesized Fe–N–C catalysts in a H 2 /Ar atmosphere to break the C─N bonds near the FeN 4 sites while introducing Fe and N precursors to form the Fe 2 N 6 sites. Our theoretical calculations and experimental results demonstrate that the newly formed Fe 2 N 6 sites are structurally more stable in acidic ORR and produce negligible H 2 O 2 (<1%). Therefore, the transformed Fe–N–C catalyst exhibits an extremely low Fe demetalation ratio (0.61 at%) in 0.1 M HClO 4 after 80k cycling. More surprisingly, the transformed Fe–N–C catalyst can effectively decompose H 2 O 2 with a high decomposition rate of 15.7 mmol min −1 , approaching that of the state-of-the art Pt/C catalyst (17 mmol min −1 ). As a result, the transformed Fe–N–C catalyst assembled PEMFC operates stably for 300 h with only 7% current density attenuation, whereas that of the pristine Fe–N–C catalyst-based device declines by 84% within 100 h.}, archive = {J_ANGEW}, author = {Ruguang Wang and Jiaxin Guo and Jisi Li and Quanlu Wang and Zheng Lv and Cairong Gong and Caofeng Pan and Tao Ling}, doi = {10.1002/anie.202510671}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510671}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transforming single-atom site to dual-atom site in Fe–N–C catalysts: A universal strategy for enhancing durability in proton-exchange membrane fuel cells}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed radical enantioconvergent C─O bond formation for asymmetric cross-coupling of allylamines and CO2. ANGEW, 64(34), e202510560. (www)

  @article{ , abstract = {Upgrading abundant carbon dioxide (CO 2 ) into high-value organic molecules has garnered broad research interest for decades. Within this domain, catalytic asymmetric synthesis employing CO 2 holds great synthetic importance. Although remarkable advances have been made in asymmetric C─C bond formation using CO 2 as a C1 synthon in recent years, the development of incorporation of CO 2 as an oxygen source for asymmetric C─O bond construction remains elusive, presumably due to the formidable challenge of simultaneously addressing enantioselectivity control and reaction efficiency. Here, we demonstrate the first copper-catalyzed asymmetric C─O bond cross-coupling of allylamines and CO 2 in a radical strategy. The key innovation resides in the rational and strategic conversion of C 2 -symmetric oxazoline ligands to their C 1 -symmetric counterparts, which induces additional C─N axial chirality after coordination with copper. The resultant enantioenriched fluoroalkylated 2-oxazolidones can be further transformed into diverse functional compounds, including novel chiral amino alcohols for oxazoline ligand design and a potent bioactive insecticide analogue. Detailed mechanistic investigations elucidate a radical-mediated pathway and establish the critical role of C 1 -symmetric ligands in achieving efficient stereochemical control.}, archive = {J_ANGEW}, author = {Xiaoyan Li and Hongli Xue and Shuyu Yang and Yufei Li and Chenghan Dai and Jiaqian Mai and Jialin Li and Yajun Li and Hongli Bao}, doi = {10.1002/anie.202510560}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510560}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed radical enantioconvergent C─O bond formation for asymmetric cross-coupling of allylamines and CO2}, volume = {64}, year = {2025}, }
• (2025). Ligand-mediated activity of cu4 clusters boosts electrocatalytic nitrate reduction. ANGEW, 64(34), e202510429. (www)

  @article{ , abstract = {Surface ligands play a crucial role in modifying catalytic environments and enhancing performance through various mechanisms. However, the multivariate synergistic mechanisms, dynamic evolution patterns, and universal design principles of ligand effects remain to be thoroughly investigated. Metal clusters, with their atomically precise structures, serve as ideal models for studying ligand regulation mechanisms. Herein, we synthesized two copper clusters of N,S-bidentate ligand-protected Cu 4 (PTI) 4 and Cu 4 (BTT) 4 featuring identical metallic core structures but distinct ligand architectures and evaluated their catalytic performance for the nitrate reduction reaction (NO 3 RR). Notably, the Cu 4 (PTI) 4 cluster with stronger electron-withdrawing ligands achieved near-100% Faradaic efficiency at optimal potentials, significantly surpassing the Cu 4 (BTT) 4 . Through in situ characterization and theoretical calculations, we unveiled that enhancing the electron-withdrawing capability of ligands induces alterations in the local microenvironment and electronic structure of metal active sites, thereby exerting positive impacts on electrocatalytic NO 3 RR performance.}, archive = {J_ANGEW}, author = {Hong Chen and Kong-Sheng Qi and Xiao-Yu Dong and Ya-Ning Pei and Yu-Jie Jin and Han Zhang and Si Li and Jie Wu and Jinmeng Cai and Shuang-Quan Zang}, doi = {10.1002/anie.202510429}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510429}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-mediated activity of cu4 clusters boosts electrocatalytic nitrate reduction}, volume = {64}, year = {2025}, }
• (2025). Enantioselective nickel-catalyzed hydrogenation of α-alkylidene succinimides enabled by weak noncovalent interactions. ANGEW, 64(34), e202510401. (www)

  @article{ , abstract = {The development of asymmetric hydrogenation catalysts based on Earth-abundant metals presents a sustainable alternative to efficient but resource-limited rare-metal systems. However, these catalysts often suffer from low catalytic activity. In this study, through a combination of density functional theory (DFT) calculations and kinetic experiments, we uncovered a positive correlation between catalyst-substrate weak noncovalent interactions and catalytic efficiency in the enantioselective nickel-catalyzed hydrogenation of α-alkylidene succinimides with different N -protecting groups. The tert -butyl ( t Bu) substituent emerged as the optimal choice, significantly enhancing reactivity. This approach enabled the hydrogenation of a wide range of substrates with excellent yields (up to 99%) and enantioselectivities (up to 99% ee), achieving a substrate/catalyst (S/C) ratio of 4000—twice the efficiency of rare-metal catalysts (S/C ≤ 2000) for similar transformations. Energy decomposition analysis (EDA) of the enantiomers revealed that the high stereoselectivity is promoted by stabilizing weak noncovalent interactions in the R -configured transition state.}, archive = {J_ANGEW}, author = {Xinhong Cai and Yicong Luo and Jianzhong Chen and Wanbin Zhang}, doi = {10.1002/anie.202510401}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510401}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective nickel-catalyzed hydrogenation of α-alkylidene succinimides enabled by weak noncovalent interactions}, volume = {64}, year = {2025}, }
• (2025). Gold and bismuth trimetallic synergistic redox catalysis for non-directed C─H arylation with aryl bismuth. ANGEW, 64(34), e202510357. (www)

  @article{ , abstract = {The influence of substituent effects plays an important role on the efficiency and regioselectivity toward C─H activation of non-directed arenes. Here, an unprecedented trimetallic synergistic redox catalysis system has been developed to achieve a highly efficient and orthogonal C─H arylation of non-directed arenes with aryl bismuth. Both electron-rich and -deficient aryl bismuth can proceed C─H arylation readily, thus affording an elegant strategy for the synthesis of challenging electron-rich and sterically hindered biaryls by means of gold catalysis. Mechanistic studies reveal that Bi(V) species generated in-situ from Ar─Bi(III) and NFSI is not only an arylation reagent but also an oxidant to form a critical Au(II)─Au(II)─Bi intermediate (detected by HRMS). Interestingly, the binding Bi-moiety can modulate the electronic and steric environment of gold center through cooperative interactions, thus promoting the intramolecular transmetallation and reductive elimination. In addition, the synthetic robustness of this protocol has been demonstrated by gram-scale experiments and late-stage functionalization of complex molecules.}, archive = {J_ANGEW}, author = {Duan-Yang Liu and Sitian Zhou and Linhan Tian and Honglei Zhang and Wei He and Kai Guo and Congqing Zhu and Chengjian Zhu and Sergey N. Konchenko and Weipeng Li and Jin Xie}, doi = {10.1002/anie.202510357}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gold and bismuth trimetallic synergistic redox catalysis for non-directed C─H arylation with aryl bismuth}, volume = {64}, year = {2025}, }
• (2025). Anion-dominated calendar aging in aqueous zinc metal batteries. ANGEW, 64(34), e202510354. (www)

  @article{ , abstract = {Zinc metal batteries (ZMBs) are promising candidates for large-scale energy storage. While the majority of current research focuses on cyclic aging, the impact of calendar aging on zinc anodes has received far less attention. Here, we reveal that zinc deposition morphology, governed by anion chemistry, plays a decisive role in calendar degradation by amplifying interfacial corrosion and accelerating “dead” zinc accumulation. Notably, intrinsic corrosion rates alone do not predict degradation severity; for instance, triflate anion shows low corrosion but induces highly porous deposits and rapid aging. To address this, we propose a comprehensive electrochemical descriptor to quantify deposition morphology beyond traditional morphological characterization. Moreover, we introduce an acetatization strategy that tailors Zn 2+ solvation and promotes dense plating, effectively suppressing side reactions and “dead” zinc formation. This approach effectively curbs calendar degradation, yielding nearly a 49-fold improvement in capacity retention. Under demanding conditions (6 h aging intervals per cycle), practical anode-free Cu||ZnI 2 cells (ca. 3 mAh cm −2 ) exhibit high cycling stability, maintaining 96.2% of their initial capacity over 1000 h. These findings provide a comprehensive understanding of zinc anode degradation and offer a viable route to address calendar aging in ZMBs.}, archive = {J_ANGEW}, author = {Jiaqi Wang and Bao Zhang and Sha Luo and Xiao Huang and An Duan and Haotian Chen and Wei Sun}, doi = {10.1002/anie.202510354}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510354}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion-dominated calendar aging in aqueous zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Switching photocatalytic methane oxidation toward ethanol by tuning spin states. ANGEW, 64(34), e202510241. (www)

  @article{ , abstract = {The selective oxidation of methane (CH 4 ) has attractive potentials for mitigating global warming and producing value-added chemicals, whereas the efficient generation of multicarbon products such as ethanol remains challenging, due to the short lifetimes and high unpaired concentrations of reactive intermediates (like •OH, •CH 3 , •OCH 3 , and •CH 2 OH). Herein, we developed a medium-spin Zn–O–Fe(MS) catalyst with tunable Fe(III) spin states, which can efficiently photo-oxidize CH 4 to ethanol at ambient conditions. The unpaired electrons in d orbitals of Fe sites allow for efficient adsorption of •OH, and the e g orbital occupancy enables stabilizing different key carbon-containing intermediates (•OCH 3 versus •CH 2 OH). By balancing those two descriptors, the medium-spin Zn–O–Fe(MS) catalyst allows to achieve selective generation of •CH 2 OH intermediates with a moderate *OH coverage and subsequent coupling of •CH 3 and •CH 2 OH to ethanol. With a light intensity of 100 mW·cm −2 and water as a weak oxidant, the Zn–O–Fe(MS) catalyst exhibited a peak photocatalytic CH 4 -to-ethanol yield of 372 µmol·g −1 ·h −1 without the use of photosensitizers or sacrificial reagents, which is ∼3 times higher than the previously best reported photocatalytic CH 4 oxidation to ethanol under similar conditions. Our study suggests an attractive potential of converting CH 4 to multicarbon products by modulating spin states of the catalytic sites.}, archive = {J_ANGEW}, author = {Shuya Hao and Maoyin Wang and Leshen Zhang and Ximeng Lv and Chen Peng and Yuhang Huang and Pei Yuan and Qing Han and Gengfeng Zheng}, doi = {10.1002/anie.202510241}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510241}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switching photocatalytic methane oxidation toward ethanol by tuning spin states}, volume = {64}, year = {2025}, }
• (2025). Highly efficient circularly polarized phosphorescence from isolated molecules through intermolecular interactions. ANGEW, 64(34), e202510153. (www)

  @article{ , abstract = {Organic room-temperature phosphorescence with circularly polarization feature attracts considerable attentions owing to its unique exciton and photon properties. However, achieving high-efficiency circularly polarized phosphorescence (CPP) under ambient conditions remains a major challenge. Herein, we report a series of CPP films by doping heterocyclic molecules with a chiral propionic acid group into polyvinyl alcohol (PVA) matrix, achieving a maximum phosphorescence efficiency of 68.4% under ambient conditions. The intermolecular interactions between the chiral isolated molecules and PVA simultaneously induce circularly polarized luminescence and enhance phosphorescence efficiency, thereby improving CPP performance. Moreover, the CPP lifetimes of the films can be rationally tuned from 1 to 944 ms by subtle modification of heteroatoms on the heterocyclic chromophores. This study provides a promising approach to developing efficient CPP materials for potential applications in optoelectronics and bioelectronics.}, archive = {J_ANGEW}, author = {Xiaokang Yao and Zhenyi Lin and Xiaobing Liu and Huili Ma and Xiao Wang and Wei Huang and Zhongfu An}, doi = {10.1002/anie.202510153}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510153}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient circularly polarized phosphorescence from isolated molecules through intermolecular interactions}, volume = {64}, year = {2025}, }
• (2025). Transition metal Atom–Cluster synergistic modification with tuned d-band center imparts longevous potassium metal anodes. ANGEW, 64(34), e202510150. (www)

  @article{ , abstract = {The tailored nucleation and growth of potassium metal over a current collector is essential to realize longevous potassium metal anodes. The commercial current collector lacks sufficient nucleation sites and fails to guide uniform deposition, underscoring the request for interfacial modulation maneuvers. Herein, we develop transition metal atom–cluster moiety decorated N-doped hollow carbon nanosphere to modify the Al current collector. In a Fe model system, the Fe single atoms provide high surface energy and fast charge transfer, while Fe clusters serve as local electron reservoirs. This cooperative architecture manages to tune the d-band center, accordingly promoting the potassium capture and minimizing the nucleation overpotential to merely 4 mV. Theoretical simulations and in situ microscopic/spectroscopic characterizations evidence that the synergistic modification markedly accelerates potassium plating/stripping kinetics, enabling prolonged symmetric-cell cycling (approaching 3000 h) and stabilized full-cell performance (0.022% decay rate per cycle over 2000 cycles). This strategy could be extended to other transition metals (e.g., Co, Ni, or Cu), offering a paradigm for atomic-level interfacial engineering toward reversible alkali metal batteries.}, archive = {J_ANGEW}, author = {Qian Liu and Yongbiao Mu and Tao Ye and Xueyu Lian and Yiwen Su and Xiaopeng Chen and Zixiong Shi and Zixiang Meng and Lin Zeng and Zhongti Sun and Jingyu Sun}, doi = {10.1002/anie.202510150}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510150}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transition metal Atom–Cluster synergistic modification with tuned d-band center imparts longevous potassium metal anodes}, volume = {64}, year = {2025}, }
• (2025). Photoswitchable catalytic divergent synthesis by a viologen-functionalized lanthanide-organic tetrahedral cage. ANGEW, 64(34), e202510095. (www)

  @article{ , abstract = {Photoswitchable catalysis presents a significant challenge, particularly in the modulation of reaction pathways. In this study, we describe a redox-active lanthanide-organic tetrahedral cage 1 , self-assembled from a viologen-functionalised ditopic tridentate ligand and Eu(III) ions. Complexation-induced charge redistribution and spatial rearrangement of ligands in the assembly endow 1 with distinct photochromic properties and redox activities compared to free ligand L . 1 can serve as a photoswitchable catalyst for divergent chemical transformations of various tetraarylborates, giving biaryls and phenols via photo-oxidative coupling reaction under 365 nm light irradiation, or producing mono-arene products through catalytic de-composition process in the absence of light. This work represents the first example of photoswitchable divergent synthesis by a single self-assembled coordination cage, paving the way for the design and construction of novel supramolecular edifices with switchable functions.}, archive = {J_ANGEW}, author = {Ke-Han Tang and Yu-Xi Tian and Fan Yin and Wei-Hui Zhuang and Shao-Jun Hu and Li-Peng Zhou and Jian Yang and Qing-Fu Sun}, doi = {10.1002/anie.202510095}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoswitchable catalytic divergent synthesis by a viologen-functionalized lanthanide-organic tetrahedral cage}, volume = {64}, year = {2025}, }
• (2025). Self-healable poly(ionic liquid) copolymers driven by polar and dipolar forces. ANGEW, 64(34), e202510066. (www)

  @article{ , abstract = {Commodity aliphatic and aromatic acrylic-based copolymers self-heal due to ubiquitous key-and-lock , ring-and-lock , and fluorophilic-σ-lock van der Waals (vdW) interactions. However, the role of these interactions in the presence of covalently copolymerized ionic liquid (IL) is not known. This study is driven by the hypothesis that covalently incorporated cation–anion pairs to form poly(ionic liquid) copolymers (PILCs) can perturb inter- or intra-chain vdW interactions reflected in mechanical and electrical responses. To test this hypothesis, we synthesized a series of PILCs comprising of pentafluorostyrene (PFS) and imidazolium-based IL monomers with variable-length aliphatic tails (methyl and butyl). Using a combination of 2D 1 H- 1 H and 19 F - 19 F NOESY NMR and FTIR measurements supplemented by molecular dynamic (MD) simulations, these studies demonstrate that preferentially alternating/random PILCs topologies facilitate self-healing. The introduction of cation–anion moieties modifies the fluorophilic-σ-lock interactions and, along with longer aliphatic tails ─(CH 2 ) 3 CH 3 covalently attached to the imidazolium cation, enhances cation-anion mobility, thus faster recovery from mechanical damage occurs. These findings underline how precise control over dipolar and ionic interactions through copolymer composition enables self-healing in PILCs. These insights may open pathways for designing sustainable, mechanically resilient materials for applications in energy storage and energy harvesting.}, archive = {J_ANGEW}, author = {Samruddhi Gaikwad and Jiahui Liu and Nyx Mashkow and Marek W. Urban}, doi = {10.1002/anie.202510066}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510066}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-healable poly(ionic liquid) copolymers driven by polar and dipolar forces}, volume = {64}, year = {2025}, }
• (2025). Communicative nanomotors reprogram cancer cell death via pyroptosis. ANGEW, 64(34), e202510014. (www)

  @article{ , abstract = {Nanomotors offer significant advantages over passive nanoparticles in biomedical applications. However, their potential has been largely restricted to cargo transport, with limited capacity for interaction with biological systems. Here, we present next-generation self-assembled nanomotors that not only exhibit chemotactic motility but also actively communicate with cells, reprogramming cell fate by inducing pyroptosis. These nanomotors are designed to respond to elevated reactive oxygen species (ROS) in the tumor microenvironment, triggering nitric oxide (NO)-driven propulsion and selective mitochondria targeting via triphenylphosphine (TPP) surface engineering. This interaction induces mitochondrial damage, cytochrome c release, and activation of gasdermin E (GSDME)-mediated pyroptosis. Furthermore, their chemotactic motility facilitates deeper tumor tissue penetration in 3D spheroids, demonstrating their ability to navigate physiological barriers. By shifting the paradigm from motility-driven to interactive nanomedicine, this study establishes a transformative platform for targeted cancer therapy.}, archive = {J_ANGEW}, author = {Mingchen Sun and Luc van Oss and Chenxuan Wan and Daniela A. Wilson}, doi = {10.1002/anie.202510014}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202510014}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Communicative nanomotors reprogram cancer cell death via pyroptosis}, volume = {64}, year = {2025}, }
• (2025). Blood retention and kidney clearance of renal-clearable gold nanoparticles strongly correlate with renal injury biomarkers. ANGEW, 64(34), e202509978. (www)

  @article{ , abstract = {Renal-clearable engineered nanoparticles are typically filtered through the glomeruli and transported along the renal tubules before entering the bladder. However, the effects of glomerular leakage and tubular injury, two common features of kidney diseases, on nanoparticle transport remain poorly understood. Herein, we investigated the blood retention, kidney accumulation, and renal clearance of Au₂₅(SG)₁₈ in a doxorubicin-induced acute kidney injury (AKI) mouse model. By correlating its transport with proteinuria and urinary kidney injury molecule-1 (KIM-1), endogenous biomarkers of glomerular leakage and proximal tubular injury, respectively, we found that glomerular leakage, as indicated by a >50-fold increase in proteinuria, did not enhance its blood clearance. Instead, tubular injury significantly reduced glomerular filtration, resulting in elevated blood retention, increased kidney accumulation, and reduced renal clearance of Au₂₅(SG)₁₈. Moreover, Au₂₅(SG)₁₈ blood retention exhibited a very strong positive correlation with urinary KIM-1 (Pearson's coefficient r = 0.90), much stronger than KIM-1 correlations with conventional glomerular filtration blood markers such as serum creatinine. This suggests that Au₂₅(SG)₁₈ could serve as a sensitive exogenous blood marker of tubular injury, expanding the diagnostic potential of renal-clearable nanoparticles in kidney diseases.}, archive = {J_ANGEW}, author = {Samira Ahrari and Yi Luo and Xuhui Ning and Qi Cai and Nilum Rajora and Ramesh Saxena and Mengxiao Yu and Jie Zheng}, doi = {10.1002/anie.202509978}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Blood retention and kidney clearance of renal-clearable gold nanoparticles strongly correlate with renal injury biomarkers}, volume = {64}, year = {2025}, }
• (2025). Spatiotemporal regulation in porous organic cage Salt–Metal cluster hybrids for efficient orthogonal tandem catalysis. ANGEW, 64(34), e202509941. (www)

  @article{ , abstract = {Developing artificial biomimetic catalysts with precise spatiotemporal control remains challenging. Here, we present a pH-responsive organic cage salt containing quaternary ammonium moieties ([QA-Cage]-12X, X═Cl or Br counteranions) as a platform for constructing such catalysts. Thermally induced electron transfer from counteranions to ammonium moieties generates radicals throughout cage skeletons ([QA-Cage] • -12X), which, combined with nanocavity confinement, facilitates metal precursor reduction and Pd cluster encapsulation, yielding the hybrid catalyst, Pd@[QA-Cage] • -12X. The pH-responsive cages enable switching between two catalytic states: Pd@[QA-Cage] • -12X, where radicals serve as active sites while Pd accessibility is hindered by numerous counteranions, and Pd@A-Cage, where neutralization of ammonium cages to non-radical amine cages (A-Cage) restores Pd accessibility by removing counteranions and modulating Pd surface charge. This dynamic switching allows real-time modulation of site-specific activity in single-step reactions. Sequential activation of dual active sites by acid-base stimuli enables tandem catalysis. Moreover, fine-tuning the protonation degrees of quaternary ammonium groups with base stimuli unveils an optimized catalyst, Pd@[PQA-Cage] • -6X (where PQA-Cage refers to partially quaternized ammonium cages). Such a spatiotemporal control maximizes cooperative performance by balancing spatially isolated radicals and Pd sites for efficient orthogonal tandem catalysis of incompatible oxidation and reduction reactions in one pot.}, archive = {J_ANGEW}, author = {Jun-Yu Li and Jia-Chen Wang and Jun-Hao Zhou and Ke Zhao and Si-Hua Liu and Xue-Jing Zhao and Shi-Long Han and Liao-Yuan Yao and Jian-Ke Sun}, doi = {10.1002/anie.202509941}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509941}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatiotemporal regulation in porous organic cage Salt–Metal cluster hybrids for efficient orthogonal tandem catalysis}, volume = {64}, year = {2025}, }
• (2025). Dual chemical scissors strategy enables 1D antimony selenates with ultraviolet nonlinear optical properties. ANGEW, 64(34), e202509917. (www)

  @article{ , abstract = {The rational, function-driven design of advanced inorganic functional materials remains a significant challenge, primarily attributed to their inherently complex and highly connected 3D frameworks of most oxide-based systems. Herein, we report a “dual chemical scissors” strategy that synergistically combines the effects of fluoride ions and stereochemically active lone pairs to precisely modulate local coordination environments and enable controlled dimensional reduction. Using this approach, we successfully synthesized the first series of non-centrosymmetric 1D antimony selenates—RbSbF 2 SeO 4 (I), Rb 2 Sb 2 F 6 SeO 4 (II), and Rb 2 Sb 3 F 9 SeO 4 (III). These compounds feature well-defined helical chain structures constructed from SbO x F y polyhedra and SeO 4 tetrahedra, resulting in pronounced optical anisotropy and robust nonlinear optical (NLO) properties. Among the series, RbSbF 2 SeO 4 (I) stands out with an exceptional combination of a broad optical transparency window (0.26–10 µm), a strong second-harmonic generation response (5.4 × KDP), and moderate birefringence (0.12 at 546 nm), positioning it as a highly promising candidate for ultraviolet NLO applications. This work establishes a powerful and generalizable structural design paradigm for constructing polar low-dimensional architectures and underscores the effectiveness of targeted coordination modulation in advancing high-performance optical materials.}, archive = {J_ANGEW}, author = {Xuehua Dong and Ling Huang and Hongmei Zeng and Zhien Lin and Kang Min Ok and Guohong Zou}, doi = {10.1002/anie.202509917}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509917}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual chemical scissors strategy enables 1D antimony selenates with ultraviolet nonlinear optical properties}, volume = {64}, year = {2025}, }
• (2025). Electrocatalytic C─S cross-coupling via engineered frustrated lewis acid-base pairs for high-efficiency methanesulfonate synthesis. ANGEW, 64(34), e202509851. (www)

  @article{ , abstract = {The electrochemical synthesis of sulfonyl compounds under mild conditions remains a significant challenge due to the reliance on harsh reagents, high energy consumption, and low selectivity in conventional methods. Herein, we report a novel strategy for efficient C─S bond formation through in situ modulation of frustrated Lewis acid-base pairs within a copper-based metal-organic framework (CuBDC-XN). By precisely engineering electron-deficient Cu Lewis acid sites and electron-rich XN-functionalized Lewis base sites, this bifunctional catalyst enables the synergistic co-reduction of SO 3 2− and CO 2 into methanesulfonate (MS) at ambient conditions with a Faradaic efficiency of 13.77% (−0.78 V versus RHE). Mechanistic studies reveal that the frustrated Lewis pairs selectively stabilize key intermediates (*CHO and SO 3 2− ) via electrostatic interactions, facilitating nucleophilic attack and C─S coupling with a reduced energy barrier (0.48 eV). In situ spectroscopic analyses and DFT calculations further elucidate the dynamic adsorption-configuration regulation and intermediate evolution pathway. This work not only establishes a molecular-level understanding of cooperative Lewis acid-base catalysis but also provides a universal design principle for the sustainable electrosynthesis of value-added organosulfur compounds.}, archive = {J_ANGEW}, author = {Yuhang Gao and Menglong Sun and Yuan Jing and Kaiheng Zhao and Lili Chen and Yangyang Guo and Zhiqin Liang and Yijun Yang and Fangli Yuan and Tingyu Zhu and Xi Wang and Jiannian Yao}, doi = {10.1002/anie.202509851}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509851}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrocatalytic C─S cross-coupling via engineered frustrated lewis acid-base pairs for high-efficiency methanesulfonate synthesis}, volume = {64}, year = {2025}, }
• (2025). Modular access to P(V)-stereogenic compounds via cu-catalyzed desymmetrization of (Thio)Phosphonic dichlorides. ANGEW, 64(34), e202509807. (www)

  @article{ , abstract = {Chiral phosphorus(V) centers—particularly those bearing fully heteroatom-substituted frameworks—are key stereochemical motifs in pharmaceuticals, nucleic acid therapeutics, and functional materials. However, their stereoselective construction remains a long-standing challenge in synthetic chemistry. Here, we report a copper-catalyzed desymmetrization strategy enabled by rationally engineered PIM ligands that affords broad and modular access to structurally diverse P(V)-stereogenic compounds. By harnessing the tunable Lewis acidity and well-defined chiral environment of the catalyst—together with the distinct mechanistic features of chiral Lewis acid catalysis—this strategy overcomes the substrate scope limitations that have constrained traditional approaches. The method demonstrates broad functional group tolerance and delivers high levels of stereocontrol across seven distinct substitution patterns, including the efficient construction of chiral P═S motifs previously considered synthetically challenging. Importantly, the approach enables efficient late-stage derivatization of nucleosides and their analogs, thereby providing a general entry point to stereodefined P(V)-containing bioactive molecules. This work not only expands the utility of transition-metal Lewis acid catalysis in phosphorus chemistry, but also establishes a versatile framework for applications in drug discovery and nucleic acid-based therapeutics where precise stereochemical control is essential.}, archive = {J_ANGEW}, author = {Hong-Qing Yao and Yue-Ming Cai and Tian Xie and Ji-Yuan Lv and Shuai-Shuai Fang and Ming-Hong Li and Ming Shang}, doi = {10.1002/anie.202509807}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509807}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular access to P(V)-stereogenic compounds via cu-catalyzed desymmetrization of (Thio)Phosphonic dichlorides}, volume = {64}, year = {2025}, }
• (2025). Si/Carbon-dots with surface N-C sites promoting proton and electron transfers in oxygen reduction reaction. ANGEW, 64(34), e202509790. (www)

  @article{ , abstract = {The oxygen reduction reaction (ORR) can proceed through either a two- or four-electron pathway, both of which are important for a wide range of applications. The intermediate conversion of *O 2 ⁻ + H⁺ → *OOH recognized as the rate-determining step in ORR, with its efficiency strongly dependent on the nature of active sites at the surface of a catalyst. Herein, Si-supported carbon dots (Si-CDs) are introduced as cocatalysts in a photocatalytic system, where their nitrogen–carbon sites play a pivotal role in lowering the energy barrier for *OOH formation by promoting proton and electron transfers, thus enhancing the H 2 O 2 production rate in ORR. This strategy is broadly applicable across a wide range of photocatalysts, both with and without use of sacrificial agents. The H 2 O 2 production rate for Zn 0.5 Cd 0.5 S (30 mg) increased from 13.0 to 40.9 µmol h −1 when 0.6 mg of Si-CDs were added. In-situ characterizations and theoretical simulations are conducted to reveal the reaction pathway and the reduced energy requirements for the *O 2 ⁻ + H⁺ → *OOH conversion. This study provides a unique example of overcoming a key barrier in ORR using a metal-free catalyst and promotes potential applications in various fields.}, archive = {J_ANGEW}, author = {Yankun Wang and Mingxian Zhang and Haihua Wu and Meirong Huang and Yuanxing Fang and Masakazu Anpo and Xinchen Wang}, doi = {10.1002/anie.202509790}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Si/Carbon-dots with surface N-C sites promoting proton and electron transfers in oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Wide-temperature, high-voltage, flame-retardant electrolyte for 4.8 v Li||NCM94 batteries. ANGEW, 64(34), e202509744. (www)

  @article{ , abstract = {All-climate lithium metal batteries attract great interest, but their poor safety and cycling performance hinder their applications, especially with high cut-off voltage nickel-rich layered oxide cathode. Herein, we develop a high-voltage, wide-temperature, and flame-retardant electrolyte for Li|| LiNi 0.94 Co 0.05 Mn 0.01 O 2 (NCM94) batteries with excellent cycling performance through constructing highly Li + -conductive, lithophilic gradient cathode electrolyte interphase (CEI). Such CEI exhibits a gradual decrease in C─F and a gradient increase in LiF and LiB x O y from the outside to the inside, which effectively inhibits structural degradation of the NCM94 cathode. With an excellent CEI, Li|| NCM94 batteries show outstanding cycling stability and wide temperature applicability (−40∼60 °C). The battery could exhibit a capacity retention of 87% after 200 cycles at 4.8 V, and deliver 112% (or 56%) of their room-temperature capacity at 60 °C and −40 °C, respectively. Furthermore, as-constructed 7.6 Ah pouch cell could run 145 cycles with an energy density of 541 Wh kg −1 . This work provides the guidance on designing electrode–electrolyte interfaces for wide-temperature, high-voltage lithium metal batteries.}, archive = {J_ANGEW}, author = {Chao Li and Yong Li and Tao Su and Lei Liu and Zhimeng Hao and Gaojing Yang and Jianmin Ma}, doi = {10.1002/anie.202509744}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Wide-temperature, high-voltage, flame-retardant electrolyte for 4.8 v Li||NCM94 batteries}, volume = {64}, year = {2025}, }
• (2025). Regioreversed carbosulfenylation of fluoroalkenes via nickel-mediated radical sorting. ANGEW, 64(34), e202509664. (www)

  @article{ , abstract = {Carbosulfenylation of olefins represents an important class of reactions for the synthesis of structurally diverse organosulfur compounds. Previous studies typically yield 1,2-regioselectivity. In the context of diversity-oriented synthesis, accessing the regioreversed products is desirable, significantly broadening the scope of these reactions. In this study, we report a nickel-catalyzed 2,1-carbosulfenylation of trifluoromethyl- and gem -difluoroalkenes, using free thiols and benzyl bromides as sulfur and carbon sources, respectively. The unusual regioselectivity observed is enabled by a “radical sorting” mechanism. The Ni catalyst activates benzyl bromide to generate a benzylic radical that undergoes hydrogen atom transfer (HAT) with the thiol to form a sulfur-centered radical. The sulfur radical subsequently adds to the fluoroalkenes, resulting in an α-fluoroalkyl C-radical. This radical undergoes S H 2 with a Ni–CH 2 Ar to form a C(sp 3 )─C(sp 3 ) bond and quaternary center, ultimately producing valuable fluoroalkyl thioethers. Isotopic labeling experiments corroborate a hydrogen atom transfer (HAT) event within the working mechanism.}, archive = {J_ANGEW}, author = {Chuan Zhu and Qian Liu and Nannan Wang and Rui Ma and Kai Chen and Patrick J. Walsh and Kai Guo and Chao Feng}, doi = {10.1002/anie.202509664}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioreversed carbosulfenylation of fluoroalkenes via nickel-mediated radical sorting}, volume = {64}, year = {2025}, }
• (2025). Stepwise acetylene insertion and ammonia activation at a digallene and diindene. ANGEW, 64(34), e202509661. (www)

  @article{ , abstract = {Sequential [2 + 2] cycloaddition reactions between acetylene and the digallene and diindene compounds (ETer) 2 (E = Ga, In; Ter = 2,6-Dipp 2 -C 6 H 3 ; Dipp = 2,6-diisopropylphenyl) are described. Careful control of the reaction conditions leads to selective formation of four- and six-membered rings with 2π E 2 C 2 and 4π E 2 C 4 cores, respectively. A structural analysis of the heterocycles by single crystal X-ray diffraction suggests limited electronic delocalization within the rings, which is borne out in their reactivity. For example, the six-membered cyclohexadiene analogues exhibit Lewis-acidic behavior and can form stable, isolable adducts with ammonia. Upon heating, these adducts transform into the corresponding bimetallic triel amides with concomitant generation of ethene.}, archive = {J_ANGEW}, author = {Álvaro García-Romero and Israel Fernández and Jose M. Goicoechea}, doi = {10.1002/anie.202509661}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stepwise acetylene insertion and ammonia activation at a digallene and diindene}, volume = {64}, year = {2025}, }
• (2025). A recyclable cooperative approach for selective lithium recovery from industrial-grade spent lithium-ion battery black mass via oxidative delithiation and complexation mechanism. ANGEW, 64(34), e202509571. (www)

  @article{ , abstract = {Extracting lithium selectively from an industrial-grade lithium-ion battery (LIB) black mass having multiple metal ions is challenging but crucial from an industrial standpoint. However, most of the methods involve harsh conditions and sacrificial reagents, are energy-intensive and time-consuming, and generate secondary pollution. This study presents a lithium selective, ligand-assisted cooperative approach for the selective leaching of lithium under mild conditions. It is revealed that the synergistic actions of anthraquinone salt (Na 2 AQAc) and H 2 O 2 generate highly reactive oxygen species (ROS) such as • OH, • O 2 − , and 1 O 2 that facilitate oxidative delithiation supported by spin trapping EPR and quenching experiments. As a result, a phase transition of cathode material and concurrent lithium abstraction by the ligand, forming an octanuclear lithium complex ([Li 8 (AQAc 2− ) 2 (μ-OH 2 ) 2 (H 2 O) 12 ] 4+ ) in the leachate was observed. Consequently, a leaching efficiency of 97% with over 99% selectivity was achieved under the optimized conditions of 3.5% H 2 O 2 (v/v), 30 °C, 72 mM Na 2 AQAc, 40 g L −1 pulp density, and a reaction time of 1 h. A recycling strategy was demonstrated to recover anthraquinone acid, and lithium was separated as high-purity Li₂CO₃. This method offers the advantages of room-temperature operation, neutral pH conditions, shorter time duration, minimal reagent usage, and the ability to recycle the reagents.}, archive = {J_ANGEW}, author = {Nishu Choudhary and Sanjay Yadav and Hardipsinh Gohil and Srinu Tothadi and Alok Ranjan Paital}, doi = {10.1002/anie.202509571}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A recyclable cooperative approach for selective lithium recovery from industrial-grade spent lithium-ion battery black mass via oxidative delithiation and complexation mechanism}, volume = {64}, year = {2025}, }
• (2025). Efficient electro-oxidation of ethylene to 2-chloroethanol on SnO2 through dual-adsorbate pathway. ANGEW, 64(34), e202509534. (www)

  @article{ , abstract = {Electrified 2-chloroethanol synthesis serves as a promising alternative to conventional ethylene oxidation with corrosive hypochlorous acid (HClO) and offers the opportunity for sustainable pharmaceutical production. However, the instability of locally generated HClO and the competing water oxidation largely limit the efficiency of this electrochemical process. Here we report a new reaction pathway involved in the ethylene oxidation toward 2-chloroethanol, featuring co-adsorbed chloride (*Cl) and hydroxide (*OH) species on a tin dioxide (SnO 2 ) anode. This dual-adsorbate pathway favors the efficient ethylene oxidation, giving rise to a large current density of 100 mA cm −2 for at least 50 h and a high Faradaic efficiency (FE) of up to 82% for the 2-chloroethanol product. This work opens an avenue for electrifying the synthesis of important organic molecules via simultaneously modulating the adsorption of multiple active intermediates.}, archive = {J_ANGEW}, author = {Xinwei Li and Xiaoshuang Yin and Chang Long and Caoyu Yang and Xiaoyu Fan and Xiaoyu You and Xuewei Huang and Zhiyong Tang}, doi = {10.1002/anie.202509534}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509534}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient electro-oxidation of ethylene to 2-chloroethanol on SnO2 through dual-adsorbate pathway}, volume = {64}, year = {2025}, }
• (2025). Active edge sites engineering on amorphous Co–Mn spinel-based oxides for efficient peroxymonosulfate activation. ANGEW, 64(34), e202509527. (www)

  @article{ , abstract = {Rational modulation of edge active sites in the Fenton-like reaction, utilizing defect engineering to form efficient catalytic activity centers, is a hot topic in the heterogeneous catalysis field, yet the applicability of large-scale manufacturing remains a severe challenge. Herein, a general wet-chemical approach is reported to large-scale prepare porous CoMn 2 O 4 with abundant active edge sites for enhanced peroxymonosulfate (PMS)-based Fenton-like activation without using a template or heat treatment. The obtained Turing-type structure not only can be assembled into spatially restricted domain CoMn 2 O 4 nanoreactors but also greatly facilitates the exposure of active edge sites with oxygen-rich vacancies in promoting PMS adsorption and interfacial charge transfer. The unique CoMn 2 O 4 /PMS system exhibited efficient and stable removal of organic pollutants with dominant nonradical ( 1 O 2 ) pathways and maintained a degradation rate of 99.8% within 5 min after seven-cycle runs. Moreover, the application prospect of the PMS-based Fenton-like process for large-scale wastewater treatment, including sulfadiazine (SD) antibiotics in real river water and real pharmaceutical wastewater, was demonstrated by the fixed-bed tower reactor and the in-situ floating water treatment device. This work will provide guidance for the development of low-cost and efficient heterogeneous PMS-activation catalysts through rational defect engineering.}, archive = {J_ANGEW}, author = {Huajie Xu and Mengyu Zhang and Qian Zhang and Junrong Wu and Xiaofeng Zhou and Jiaojiao Zhang and Fuying Hao and Zhaodi Liu and Liangquan Sheng and Yu Tang}, doi = {10.1002/anie.202509527}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509527}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Active edge sites engineering on amorphous Co–Mn spinel-based oxides for efficient peroxymonosulfate activation}, volume = {64}, year = {2025}, }
• (2025). Dynamic regulation of radical photochromism and photoluminescence via polymer polarity. ANGEW, 64(34), e202509506. (www)

  @article{ , abstract = {While polymer matrices are widely used to protect excited-state phosphors from oxygen and moisture quenching by providing a network that enables long-lived room-temperature phosphorescence (RTP), the influence of polymer polarity on phosphors for stable free radicals with radical luminescence (RL) has not been well studied. In this work, naphthalene diimide (NDI) derivatives, denoted as NDI-XC-OH (X = 2–6), featuring different alkyl alcohol chains, exhibit multi-responsive and tunable RTP and RL properties through polymer matrix polarity regulation. Experimental results reveal that NDI-XC-OH •− anion radicals are generated via not only photoinduction in the excited state but also intermolecular interactions of polar matrix in the ground state. Theoretical simulations demonstrate that polar polymers rich in hydrogen-bonding donors (e.g., ─NH 2 , ─NH─, and ─OH), where electrostatic interactions dominate over dispersion (E/D > 1), more readily induce anion radicals compared to polar polymers rich in acceptors (e.g., ─CN and ─CO─), where dispersion interactions outweigh electrostatic effects (E/D < 1). These derivatives exhibit potential applications in information encryption and volatile amine detection due to their chromic and luminescent properties. These findings offer perspectives on the role of polymer matrix polarity in modulating anion radical behavior, and mechanistic insights into the balance between RTP and RL properties.}, archive = {J_ANGEW}, author = {Quanchi Tian and Qiuyue Ding and Chao Xu and Lunjun Qu and Kaiti Wang and Chaolong Yang and Yanli Zhao}, doi = {10.1002/anie.202509506}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509506}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic regulation of radical photochromism and photoluminescence via polymer polarity}, volume = {64}, year = {2025}, }
• (2025). Engineering Crystalline/Amorphous interfaces for enhanced CO2 electroreduction. ANGEW, 64(34), e202509502. (www)

  @article{ , abstract = {In the request for carbon neutrality, CO 2 electroreduction to high-value fuels and chemicals, particularly formic acid, has become as a promising approach. However, implementing it on an industrial scale is hindered by the catalyst instability under high current densities and the excessive energy consumption of conventional electrolysis systems. To tackle these challenges, we propose an amorphization strategy to regulate catalyst reconstruction under operational conditions. In particular, an amorphous In-based catalyst, InO x (OH) 3−2x , was designed and achieved high Faradaic efficiencies of 98% at −800 to −1000 mA cm −2 for CO 2 electroreduction to formate, while maintaining stability for 100 h. Mechanistic studies show that InO x (OH) 3−2x undergoes partial reduction to stable crystalline/amorphous In/In─OH interfaces instead of fully reducing to metallic In, enhancing the adsorption of CO 2 and *OCHO intermediate. To improve the economic viability of electrolysis system, a CO 2 electroreduction coupled with waste plastics electrooxidation system for formate production was constructed. Compared to conventional electrolysis system, the coupled system reduced energy consumption by 34.7% and increased formate production by 49.7%, offering a more energy-efficient and cost-effective approach to CO 2 electroreduction.}, archive = {J_ANGEW}, author = {Bingkun Li and Ziyi Zhong and Hao Li and Mingzhu Yue and Qingman Niu and Lu Liu and Wenfu Xie and Min Li and Mingfei Shao and Qiang Wang}, doi = {10.1002/anie.202509502}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering Crystalline/Amorphous interfaces for enhanced CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Chemically recyclable alternating poly(thioether-alt-ester)s with tunable properties enabled by substitution effects and stereochemistry. ANGEW, 64(34), e202509468. (www)

  @article{ , abstract = {The development of innovative poly(ether-ester)s with perfectly alternating ether and ester functionalities to overcome the trade-offs between the polymer's depolymerizability and performance properties is in high demand for advanced material applications and sustainable development. Herein, we prepared a series of enantiopure cyclic thioether-ester monomers bearing various pendant substituents by a facile “polycondensation-depolymerization” strategy. The controlled ring-opening polymerizations of these enantiopure monomers will afford stereoregular poly(thioether- alt -ester)s with structural diversity. The varieties of substituent size, position and stereo-configuration provide the opportunity to systematically investigate polymerization kinetics and thermodynamics as well as structure-properties relationship for the resulting poly(thioether -alt -ester)s. The strategic positioning of α-, γ-, and δ-substituents coupled with stereoregular chain architectures and stereocomplex formation enables wide-range modulation of the polymer's thermal and mechanical properties. A(hard)-B(soft)-A(hard) triblock thermoplastic elastomers with good mechanical performance and elastic recovery were also created by sequential polymerization. Of note, these polymers can be chemically recycled by either ring-closing depolymerization or alcoholysis, with high monomer regeneration efficiency. The systematic investigation of substitution effects and structure-property relationships in this work provides a molecular blueprint for designing novel chemically recyclable polymers with high performance.}, archive = {J_ANGEW}, author = {Mingqian Wang and Zhiqiang Ding and Jingying Xiao and Yilong Liao and Zhe Ma and Yuesheng Li and Bin Wang}, doi = {10.1002/anie.202509468}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509468}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemically recyclable alternating poly(thioether-alt-ester)s with tunable properties enabled by substitution effects and stereochemistry}, volume = {64}, year = {2025}, }
• (2025). Synthesis of chirally chimeric protein nanoparticle vaccines via mirror-image spy chemistry. ANGEW, 64(34), e202509419. (www)

  @article{ , abstract = {Mirror-image proteins and nucleic acids exhibit remarkable biostability and bioorthogonality, offering a promising strategy to enhance the longevity of biological therapeutics. Here, we present a modular approach for constructing complex protein architectures that integrate both natural-chirality ( L -) and mirror-image ( D -) motifs. Key to this strategy is the development of D -SpyStapler—a chemically synthesized, chirally inverted ligase that enables the efficient conjugation of D -SpyTag and D -BDTag. By exploiting the achirality of glycine (Gly), we used L -sortase to covalently link D -peptides (e.g., SpyTag or BDTag, bearing an N-terminal poly-Gly motif) to L -proteins (e.g., GFP, VLP-forming Mi3, or antigens) containing a C-terminal LPXTG sorting signal. The resulting D -SpyTagged and D -BDTagged proteins were further assembled via D -SpyStapler. This method enabled the construction of chirally chimeric VLP vaccines displaying antigens derived from malaria parasites and coronaviruses in various forms—recombinant proteins or synthetic peptides—providing significant flexibility and modularity for vaccine design. The resulting chirally hybrid vaccines exhibited enhanced proteolytic resistance in vitro and elicited potent immune responses in vivo. This study provides a versatile platform for developing long-acting therapeutics and vaccines.}, archive = {J_ANGEW}, author = {Songzi Kou and Chenbo Sun and Weitao Chen and Hanyu Gao and Fei Sun}, doi = {10.1002/anie.202509419}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509419}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of chirally chimeric protein nanoparticle vaccines via mirror-image spy chemistry}, volume = {64}, year = {2025}, }
• (2025). Engineering unspecific peroxygenases for enantioselective α-hydroxylation of β-ketoesters. ANGEW, 64(34), e202509359. (www)

  @article{ , abstract = {Unspecific peroxygenases (UPOs) are promising biocatalysts for selective oxyfunctionalization. Compared to cytochrome P450 enzymes (P450s), the catalytic potential of UPOs has been less investigated, largely due to their limited natural diversity and the challenges associated with their optimization through enzyme engineering. In this study, we engineered an UPO from Aspergillus niger ( Ani UPO) to catalyze the enantioselective α-hydroxylation of β-ketoesters, a valuable transformation yet to be realized in biocatalysis. Through enzyme engineering, two Ani UPO variants, Ani UPO-M3 and Ani UPO-M6, were developed to produce a wide range of enantioenriched α-hydroxy-β-ketoesters, achieving up to 97% yield, 4140 total turnover number (TTN), and >99:1 enantiomeric ratio (er). The biocatalytic process operates under mild conditions and is scalable for preparative applications. This study broadens the catalytic repertoire of UPOs and enhances their potential for industrial applications.}, archive = {J_ANGEW}, author = {Zhen-Yu Wang and Xin-Yuan Ma and Ying Wu and Yang Liu and Guang-Xin Lin and Xiao-Qi Liu and Chun Zhang and Peng Chen and Yongxiang Zheng and Zhi-Jun Jia}, doi = {10.1002/anie.202509359}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509359}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering unspecific peroxygenases for enantioselective α-hydroxylation of β-ketoesters}, volume = {64}, year = {2025}, }
• (2025). Tunable thermally activated delayed fluorescence from supramolecular polymers toward application in aqueous media. ANGEW, 64(34), e202509241. (www)

  @article{ , abstract = {Thermally activated delayed fluorescence (TADF) offers great potential for application in light emitting devices and bioimaging. Supramolecular polymers can offer intriguing properties for the same applications, such as stimuli responsiveness and self-healing owing to their dynamic intermolecular interactions. However, merging the two has remained a formidable challenge, due to the nonplanar geometry of common TADF chromophores. Herein, we overcome this challenge by utilizing a less distorted multiple resonance TADF (MR-TADF) chromophore connected to a polymerization inducing building block. The obtained supramolecular synthon is capable of assembling in aliphatic solvents due to combined interchromophore interactions and hydrogen bonding. Within the supramolecular ensemble the long-lived photoluminescence properties of the chromophore are maintained. Further modification of the photoluminescence properties could be achieved by using different supramolecular modulators in a social self-sorting approach, allowing fine-tuning of the photoluminescence lifetime and bandwidth. Notably, the extent of intermolecular interactions can switch these assemblies from kinetically to thermodynamically controlled regimes. Finally, we employ this co-assembly strategy to move from organic to aqueous media highlighting the potential toward biological applications.}, archive = {J_ANGEW}, author = {Nils Bäumer and Peiqi Hu and Miku Naruse and Soichiro Ogi and Zachary M. Hudson and Shigehiro Yamaguchi}, doi = {10.1002/anie.202509241}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509241}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tunable thermally activated delayed fluorescence from supramolecular polymers toward application in aqueous media}, volume = {64}, year = {2025}, }
• (2025). Azine-pyridine frame generated covalent organic frameworks and self-polymerized films. ANGEW, 64(34), e202509221. (www)

  @article{ , abstract = {Engineering covalent organic frameworks (COFs) into industrializable films with inherent functionalities has remained a major challenge in synthetic chemistry. Here, through developing skeletal azine-pyridine conformation, we present an effectual synthetic frame to convert a family of powdery COFs into self-polymerized COFs films under green and ambient conditions. The active proton tautomerism in our azine-pyridine frame offers a thermochromism, facilitating self-polymerization of large-area COFs films from ca. 10 nm to >30 µm thickness with outstanding chemical stability, industrializable processability, and mechanical strength. More remarkably, our azine-pyridine-based COFs first display various fresh properties, i.e., up to 1913 and 624 mg g −1 reducing capacities on ions of Au 3+ → Au 0 and Cr 6+ → Cr 3+ , 99.9% UV-blue light shielding and 97.2% transmissivity of visible lights and 10-fold increase in Zn battery lifetime. We expect that the azine-pyridine synthetic frame will serve as a generalizable route to boost the development of reticular chemistry, environmental science, and nano-electronics.}, archive = {J_ANGEW}, author = {Jingkun Li and Yuqi Wan and Zhixuan Luo and Chunming Yang and Yukihiro Ozaki and Xiuping Yan and Jian-Gan Wang and Fuwei Pi}, doi = {10.1002/anie.202509221}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Azine-pyridine frame generated covalent organic frameworks and self-polymerized films}, volume = {64}, year = {2025}, }
• (2025). N─B─N isomer induced room temperature phosphorescence: Expression, mechanistic insights, and multi-level anti-counterfeiting applications. ANGEW, 64(34), e202509104. (www)

  @article{ , abstract = {Achieving pure organic room temperature phosphorescence (RTP) materials is of great interest due to their applications in optoelectronics. However, improving RTP in pure organic materials by controlling triplet excitons is challenging due to their complex relaxation processes. Therefore, exploring effective strategies to modulate triplet excitons is crucial. Herein, we propose a N─B─N isomerization strategy to enhance RTP performance. Two isomers containing HN─B─NH units (B 2 {1,2-(NH) 2 C 6 H 4 } 2 ), namely 1,1-DB and 1,2-DB, were synthesized to explore their RTP properties. Intriguingly, 1,1-DB exhibited excellent RTP, whereas 1,2-DB displayed negligible phosphorescence. The N─B─N unit in 1,1-DB optimizes molecular configuration and interactions, enhancing electron delocalization and stabilizing triplet excitons, which improves intersystem crossing (ISC) and spin-orbit coupling (SOC) while reducing nonradiative decay, thus enabling RTP. Additionally, based on phosphorescence resonance energy transfer, multicolor afterglows were achieved by doping fluorescein into 1,1-DB. This work not only provides a new class of RTP materials but also offers valuable insights for the discovery and optimization of rational designs in RTP materials, potentially triggering the exploration of new functions and properties within boron-nitrogen molecular systems.}, archive = {J_ANGEW}, author = {Jianhua Liu and Junxiong Yao and Ruping Mu and Xinyi Mao and Haihua Li and Jianqi Sun and Jifeng Huang and Qiang Feng and Xiaohua Cao and Jianguo Wang and Huanan Huang}, doi = {10.1002/anie.202509104}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {N─B─N isomer induced room temperature phosphorescence: Expression, mechanistic insights, and multi-level anti-counterfeiting applications}, volume = {64}, year = {2025}, }
• (2025). Upconversion lanthanide-based 2D metal-organic frameworks for multimode information encryption. ANGEW, 64(34), e202509093. (www)

  @article{ , abstract = {Luminescent 2D metal-organic frameworks (MOFs) are a class of metal-organic framework materials expanded in a 2D plane, which have a wide range of applications in fields of optoelectronic devices, sensors, and information storage due to their unique layered structure and excellent optical properties. Currently, research on luminescent 2D MOFs mainly focuses on down-shifting luminescence, while the exploration of upconversion luminescence remains in its early stages. Herein, a novel 2D Yb-PMA MOFs were synthesized, and red upconversion luminescence at 660 nm under 980 nm excitation was successfully achieved by introducing Ho 3+ as the luminescence center and using Yb 3+ as the sensitizer. In addition, multimode emitting MOFs with both upconversion and down-shifting luminescence were further constructed by codoping Tb 3+ or Eu 3+ . Inspired by the layered structure of 2D materials, multilayer stacked 2D MOFs composites were prepared by ultrasonic exfoliation method and upconversion luminescence was realized for the first time by interfacial energy transfer between different components. This strategy not only expands the optical modulation of luminescent 2D MOFs, but also provides new ideas for the construction of multifunctional luminescent materials. The upconversion/down-shifting luminescent lanthanide-based 2D MOFs designed in this work show good potential for application in the field of information encryption.}, archive = {J_ANGEW}, author = {Jiabo Chen and Yao Xie and Wanjun Yang and Renrui Sun and Feifei Xing and Gabrielle A. Mandl and John A. Capobianco and Lining Sun}, doi = {10.1002/anie.202509093}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509093}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Upconversion lanthanide-based 2D metal-organic frameworks for multimode information encryption}, volume = {64}, year = {2025}, }
• (2025). A dual-atom la2 catalyst for the oxygen reduction reaction. ANGEW, 64(34), e202509063. (www)

  @article{ , abstract = {Rare earth lanthanum element has a large atomic radius, multi-shell orbital electrons, and Fenton-like reaction inertia, on which a localized high-coordination structure can be easily formed for the favorable adsorption of reaction intermediates. However, for single-atom lanthanum sites, due to the loss of all the outmost s and d electrons, the practically vacuous outmost orbitals are stable but sleepy for the oxygen reduction reaction (ORR). Here, we synthesize a novel dual-atom La catalyst onto N-doped graphene (La 2 -NG) by a Joule ultrafast heating method, which shows a half-wave potential of 0.893 V for the ORR. The La 2 -NG-assembled zinc–air battery demonstrates a great open circuit voltage of 1.52 V and a maximal power density of 192 mW cm −2 . Operando X-ray absorption spectra reveal the change of valence states of La and the dynamic structural evolution of the La 2 -N 6 moiety embedded onto the graphene during the ORR, through which the adsorption/desorption of oxygen reduction intermediates can be reasonably regulated. Theoretical calculations further demonstrate that the La 2 -N 6 structure can decrease the reaction energy barrier and promote charge transfer.}, archive = {J_ANGEW}, author = {Jingru Sun and Tianmi Tang and Siying Zhang and Siyu Chen and Yingying Duan and Xue Bai and Xiaoqin Xu and Xiaodi Niu and Zhenlu Wang and Jingqi Guan}, doi = {10.1002/anie.202509063}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509063}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A dual-atom la2 catalyst for the oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Reversing blocking order of trithiocarbonate-mediated RAFT polymerizations using photocatalysis. ANGEW, 64(34), e202509029. (www)

  @article{ , abstract = {Many acrylic–methacrylic block copolymer sequences remain inaccessible due to synthetic limitations. Herein, photoinduced electron/energy transfer (PET) catalysis is leveraged to reverse blocking order limitations in trithiocarbonate (TTC)-mediated reversible addition–fragmentation chain transfer (RAFT) polymerization. We synthesized poly(methyl acrylate- b -methyl methacrylate) by PET-RAFT using fac -Ir(ppy) 3 , achieving predictable, linear increases in molecular weight with conversion. Kinetics studies showed that adding a tertiary amine (triethanolamine) introduced a reversible redox reaction to stabilize the TTC radical during chain extensions, leading to more uniform block copolymers ( Ð < 1.47) compared to block copolymers synthesized without amine ( Ð < 1.56). To highlight the utility of this method, triblock copolymers of poly(methyl acrylate) and poly(methyl methacrylate) blocks were investigated. The order of acrylic and methacrylic blocks impacted the physical properties of compositionally similar polymeric materials. For example, a high molecular weight triblock copolymer (P(MMA- b -MA- b -MMA), M n = 564 kg mol −1 ) thermoplastic elastomer showed exceptional strain (>1600%). Overall, we report (i) a new methodology to unlock synthetic access to acrylic–methacrylic block copolymers using TTCs and photocatalysis, (ii) insight into photocatalyst-mediated radical polymerization, and (iii) synthesis of new high-performance materials.}, archive = {J_ANGEW}, author = {Jared G. Baker and Stephen J. Koehler and Katherine J. Wood and Diego Troya and Joey Gloriod and Ian C. Anderson and Darwin C. Gomez and C. Adrian Figg}, doi = {10.1002/anie.202509029}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202509029}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversing blocking order of trithiocarbonate-mediated RAFT polymerizations using photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Operando XAFS deciphering dynamic evolution of heteronuclear Cu–Ni from atomic sites to atomic clusters for enhanced CO2 electroreduction. ANGEW, 64(34), e202508932. (www)

  @article{ , abstract = {Revealing the dynamic evolution of atomic-level active sites during catalytic reactions is critical for identifying true catalytic centers and optimizing the adsorption of reaction intermediates. However, elucidating the dynamic atomic/electronic transformation mechanisms of metal sites in multimetallic systems and achieving atomic-level control remains challenging. Here, we report a potential-dependent in-plane atomic reconstruction intrinsic to Cu–Ni heteronuclear atomic sites during the electrocatalytic CO 2 reduction reaction (eCO 2 RR). Operando X-ray spectroscopy and microscopy unveil the transformation of asymmetric Cu–Ni dimers into fully exposed Cu x –Ni atomic clusters (Cu x –Ni ACs, x = 3–7) at potentials from −0.7 to −1.2 V versus RHE, anchored on porous carbon through N/S coordination. The Cu-rich evolution reshapes geometric structures of active sites, inducing gradual electron localization, thereby optimizing the adsorption energy of CO 2 intermediates as evidenced by operando measurements and theoretical analysis. Specifically, the tailored Cu 5 –Ni ACs formed at −0.9 V reduce the antibonding orbital occupancy between Cu 3 d and C 2 p states, facilitating CO 2 protonation and enhancing eCO 2 RR kinetics. These findings demonstrate high CO selectivity and catalytic stability, providing fundamental insights into the dynamic reconstruction and catalytic mechanism of atomic-scale active sites.}, archive = {J_ANGEW}, author = {Kehao Cheng and Di Shen and Yongpeng Xia and Kai Dai and Chunfeng Shao and Yong Jiang and Yong Chen}, doi = {10.1002/anie.202508932}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Operando XAFS deciphering dynamic evolution of heteronuclear Cu–Ni from atomic sites to atomic clusters for enhanced CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Reactivity of a methylene-bridged 1,3-bis(germylene) in dynamic equilibrium with its dimer. ANGEW, 64(34), e202508927. (www)

  @article{ , abstract = {We report the properties and reactivity of an unprecedented methylene-bridged 1,3-bis(germylene) derivative. In the solid state, it undergoes dimerization to afford a 1,2,4,5-tetragermacyclohexa-1,4-diene derivative (Ge 4 CHD). Moreover, theoretical calculations on Ge 4 CHD reveal σ*–π interactions between the two π orbitals (Ge═Ge) and the CH σ* orbital. This interaction is confirmed by a significant red shift in the solid-state UV–vis spectrum. In contrast to the behavior in the solid state, the Ge 4 CHD derivative dissociates in solution into a methylene-bridged 1,3-bis(germylene) derivative. The resultant 1,3-bis(germylene) derivative reacted with S 8 to form a novel cage compound containing three S and two Ge atoms. On the other hand, in the reaction with triphenylphosphine sulfide, the in situ generated 2-thia-1,3-digermabicyclo[1.1.0]butane derivative activated the benzene solvent, leading to the formation of a [2 + 2] cycloaddition product. Additionally, the 1,3-bis(germylene) derivative reacted with 4-dimethylaminopyridine (DMAP) to form a three-membered ring. Its structural parameters and the results of theoretical calculations indicated the zwitterionic character.}, archive = {J_ANGEW}, author = {Daichi Uchida and Mariko Yukimoto and Norihiro Tokitoh and Mitsuaki Yamauchi and Hiroko Yamada and Yoshiyuki Mizuhata}, doi = {10.1002/anie.202508927}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508927}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reactivity of a methylene-bridged 1,3-bis(germylene) in dynamic equilibrium with its dimer}, volume = {64}, year = {2025}, }
• (2025). Three-dimensional porphyrin and phthalocyanine-based covalent organic frameworks for boosting urea oxidation. ANGEW, 64(34), e202508783. (www)

  @article{ , abstract = {Porphyrin and phthalocyanine-based covalent organic frameworks (COFs) have emerged as versatile scaffolds for developing high-performance photo- and electrocatalysts. By enabling precise anchoring of metal species onto their cores, these COFs allow for meticulous tuning of chemical and electronic properties, facilitating single-atom distribution and achieving outstanding catalytic performance. However, the majority of these COFs are restricted to two-dimensional (2D) architectures, where the catalytic activity of the metal centers is often compromised due to eclipsed stacking layers, limiting their optimization potential. To address this challenge, we report the synthesis of three-dimensional (3D) porphyrin and phthalocyanine-based COFs with a cyt topology. This innovative structural arrangement facilitates the atomic-level distribution of distinct metal species across steric exposed networks, and the synergistic effect of bimetallic sites leads to exceptional electrocatalytic activity in urea oxidation reactions with a current density of 10 mA cm −2 at just 1.37 V RHE . This study not only broadens the topological diversity of 3D COFs but also establishes a platform for achieving uniform and accessible multimetal distributions, paving the way for synergistic electrocatalytic materials.}, archive = {J_ANGEW}, author = {Guanyu Qiao and Bolun Wang and Ziyi Zhao and Hongde Yu and Jingyang Lin and Yunyu Guo and Jiahuan Wang and Lin Li and Thomas Heine and Donghai Mei and Enquan Jin}, doi = {10.1002/anie.202508783}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508783}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three-dimensional porphyrin and phthalocyanine-based covalent organic frameworks for boosting urea oxidation}, volume = {64}, year = {2025}, }
• (2025). Self-assembled π-conjugated hole-selective molecules for UV-resistant high-efficiency perovskite solar cells. ANGEW, 64(34), e202508782. (www)

  @article{ , abstract = {Ultraviolet (UV) light-induced degradation, particularly occurring at the buried interface, has emerged as a significant stability challenge, severely limiting the widespread applications of perovskite solar cells (PSCs). Here, we rationally design and synthesize novel thiophene-modified self-assembled π-conjugated hole-selective molecules, namely (4-(3,6- bis (5-methylthiophen-2-yl)-9H-carbazol-9-yl)phenyl)phosphonic acid (Me-TPCP), affording UV-stable high-efficiency PSCs. Simultaneously incorporating phenyl and thiophene groups enhances molecular conjugation, effectively protecting the fragile bonds between the carbazole core and the phosphonic acid group. This modification results in enhanced intrinsic UV stability and improved hole transport ability of the molecule. Furthermore, thiophene grafted on the carbazole coordinates with the Pb 2+ ions in perovskite, enhancing the binding of perovskite to hole-selective molecules. Consequently, the crystallinity of the perovskite film is significantly improved, along with decreased defect density, thereby inhibiting its degradation under UV light illumination. By introducing methyl groups, the molecular stability is further enhanced, and the energy level of Me-TPCP is finely tuned, resulting in a lower interfacial energy barrier that facilitates more efficient hole extraction. With these advantages, inverted PSC devices based on Me-TPCP achieve a significantly higher efficiency of 25.62% than the control devices (23.85%). Meanwhile, these devices demonstrate a remarkable enhancement in UV stability, as well as improved operational and thermal stability.}, archive = {J_ANGEW}, author = {Shantao Zhang and Xue Wang and Yu Wu and Xinyu Li and TianAo Hou and Dehan Li and Wenjing Chen and Jianyu Li and Rongyao Lv and Yue Zhang and Zhengguo Xiao and Tao Chen and Shuang Chen and Zhimin Fang and Shengzhong (Frank) Liu and Shangfeng Yang}, doi = {10.1002/anie.202508782}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508782}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled π-conjugated hole-selective molecules for UV-resistant high-efficiency perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Spring-like behavior in [8]Helicene diimides: How helical pitch governs optical anisotropy and electronic conjugation. ANGEW, 64(34), e202508779. (www)

  @article{ , abstract = {Helicenes, with their corkscrew-shaped geometry, have emerged as prototypical molecular springs for engineering chiral functional materials through precise structural modulation. Here we introduce the design and synthesis of [8]helicene diimides ([8]HDIs) and demonstrate that the helical pitch of their backbone can be precisely tuned by bridging the imide nitrogen atoms with alkyl chains of varying lengths (C 3 –C 6 ). This approach constrains the molecular geometry to systematically control optical anisotropy, chiroptical response, and electronic communication. Remarkably, modulation of the helical pitch leads to high optical dissymmetry factors (up to 6.0 × 10 −2 ) and enhanced through-space conjugation. Furthermore, we investigate how variations in the helical pitch affect crystal packing in both enantiopure and racemic samples. Complementary quantum chemical calculations provide insights into the origins of these properties, highlighting the potential of this strategy for designing advanced chiral materials.}, archive = {J_ANGEW}, author = {Fridolin Saal and Vincenzo Brancaccio and Krzysztof Radacki and Holger Braunschweig and Prince Ravat}, doi = {10.1002/anie.202508779}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508779}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spring-like behavior in [8]Helicene diimides: How helical pitch governs optical anisotropy and electronic conjugation}, volume = {64}, year = {2025}, }
• (2025). Photoelectric/Photothermal synergy activation in floating aerogel cathode breaks neutral triphase reaction barriers for high-efficiency full-spectrum-responsive seawater batteries. ANGEW, 64(34), e202508644. (www)

  @article{ , abstract = {Harnessing natural resources (solar, seawater) to explore next-generation sustainable energy storage is an intriguing yet challenging task. Here, we establish a unique floating photoelectric/photothermal dual-activated catalytic platform based on engineered Janus aerogel that overcomes inherent mass transport/kinetics constraints in neutral triphase oxygen reaction systems to enable a full-spectrum-responsive seawater battery with ultrahigh energy efficiency. Our approach employs in situ region-selective assembly of the rationally designed fluorinated donor–acceptor polymers on carbon-nanotube aerogel (FMTAPPC), creating a new floatable FMTAPPC photoelectrode with asymmetric wettability, superior photoelectric/photothermal dual-response, and bifunctional oxygen evolution/reduction (OER/ORR) catalysis. This all-in-one integration enables floating FMTAPPC to maximize sunlight utilization for interface micro-environment regulation and adsorbate binding optimization via photoelectric/photothermal dual-activation while satisfying paradoxical wetting requirements of OER/ORR, which tunes reaction kinetics and intermediate energetics to remarkably promote both OER/ORR in neutral media. Under sunlight, floating FMTAPPC delivers large current densities for both OER/ORR–3–4 fold-enhancement over dark conditions. This enables the seawater-based Zn–air battery to simultaneously improve charge/discharge performance at high rates and deliver ultrahigh round-trip efficiency of 128.2%—surpassing most photo-assisted batteries. Mechanistic studies unveil that photoelectric/photothermal effects synergistically boost OER/ORR kinetics, while the photoelectric effect dominates intermediate energetics optimization, substantially lowering reaction energy barriers.}, archive = {J_ANGEW}, author = {Yi Lin and Fan Yang and Linfeng Zhong and Dingshan Yu}, doi = {10.1002/anie.202508644}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoelectric/Photothermal synergy activation in floating aerogel cathode breaks neutral triphase reaction barriers for high-efficiency full-spectrum-responsive seawater batteries}, volume = {64}, year = {2025}, }
• (2025). Copper-tailored Molybdenum–Nickel catalyst boosts hydrogen oxidation and suppresses parasitic oxygen reduction for durable fuel cells. ANGEW, 64(34), e202508535. (www)

  @article{ , abstract = {Numerous existing strategies struggle to mitigate reverse-current decay (RCD) during startup and shutdown in polymer electrolyte fuel cells to avoid cathode corrosion, but the added system complexity and cost are drawbacks. Here, we report that modification of a molybdenum–nickel alloy through the doping of copper enables a non-noble electrocatalyst (MoNi 3.6 Cu 0.4 ) that efficiently catalyzes hydrogen oxidation reaction (HOR) while catalytically inactive toward oxygen reduction reaction (ORR) in alkaline media, making it ideal for fuel-cell anode because the instantaneous interfacial potential jump originated from the parasitic ORR during device startup/shutdown can be surmounted. The catalyst, when assembled in the anode of an anion exchange membrane fuel cell, manifests substantially improved corrosion-resistant ability compared with that of state-of-the-art carbon-supported platinum (Pt/C) catalyst. The basis for the achieved performances reveals to be the copper dopants that increase the hydrogen bonding of interfacial water for enhanced HOR, yet weaken molecular oxygen adsorption while stabilizing hydroxyl adsorption for ORR suppression.}, archive = {J_ANGEW}, author = {Lei Zhu and Xiao-Long Zhang and Yu Yang and Ye-Cheng Li and Ye-Hua Wang and Hui-Kun Yan and Fei-Yue Gao and Yu-Cai Zhang and Zhi-Zheng Wu and Shu-Ping Sun and Pu-Gan Lu and Wanjie Song and Xiaolin Ge and Tongwen Xu and Kai-Bin Tang and Min-Rui Gao}, doi = {10.1002/anie.202508535}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508535}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-tailored Molybdenum–Nickel catalyst boosts hydrogen oxidation and suppresses parasitic oxygen reduction for durable fuel cells}, volume = {64}, year = {2025}, }
• (2025). Chirality unbound in graphene nanoribbons. ANGEW, 64(34), e202508426. (www)

  @article{ , abstract = {In this manuscript, we report the first demonstration of controlled helicity in extended graphene nanoribbons (GNRs). We present a wealth of new graphene nanoribbons that are a direct consequence of the high-yielding and robust synthetic method revealed in this study. We created a series of defect-free, ultralong, chiral cove-edged graphene nanoribbons where helical twisting of the graphene nanoribbon backbone is tuned through functionalization with chiral side chains. S -configured point chiral centers in the side chains transfer their chiral information to induce a helically chiral, right-handed twist in the graphene nanoribbon. As the backbone is extended, these helically twisted graphene nanoribbons exhibit a substantial increase in their circular dichroic response. The longest variant synthesized consists of an average of 268 linearly fused rings, reaching 65 nm in average length with nearly 10 full end-to-end helical rotations. The structure exhibits an extraordinary |Δ ε | value of 6780 M −1 cm −1 at 550 nm—the highest recorded for an organic molecule in the visible wavelength range. This new chiroptic material acts as room-temperature spin filters in thin films due to its chirality-induced spin selectivity.}, archive = {J_ANGEW}, author = {Si Tong Bao and Yongseok Hong and Haoyu Jiang and Luke T. Lackovic and Shayan Louie and Ding Xu and Fay Ng and Nicholas Olsen and Xiaoyang Zhu and Michael L. Steigerwald and Milan Delor and Colin Nuckolls and Qifeng Jiang}, doi = {10.1002/anie.202508426}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chirality unbound in graphene nanoribbons}, volume = {64}, year = {2025}, }
• (2025). Overcoming challenges in small-ring transfer: Direct decarboxylative hydroalkylation of alkenes via iron-thiol catalysis. ANGEW, 64(34), e202508377. (www)

  @article{ , abstract = {Cyclopropanes, especially those substituted with trifluoromethyl (CF 3 ) groups, are valuable scaffolds in medicinal chemistry. Their enhanced bioavailability contributes to the widespread presence of this motif in a variety of bioactive compounds. Despite the development of multiple synthetic strategies, a direct method for transferring CF 3 -containing small rings from their most abundant carboxylic acid surrogates remains a significant challenge. In this work, we overcome the challenging decarboxylation of CF 3 -cyclopropyl and CF 3 -cyclobutyl carboxylic acids while leveraging the ligand-to-metal charge transfer (LMCT) excited state of photochemically activated iron complexes. The resulting radicals were then engaged in radical addition to alkenes, followed by a timely hydrogen atom transfer (HAT) process mediated by a thiol donor. This efficient iron-thiol cooperative catalysis enables, for the first time, facile hydroalkylation of alkenes with highly reactive CF 3 -containing cyclopropyl and cyclobutyl radicals. Synergistic experimental, spectroscopic, and density functional theory (DFT) studies support the proposed reaction mechanism. Additionally, we employed the radical stabilization energy (RSE) scale, developed using isodesmic equations computed at the DFT level, aiming to provide a better understanding of the reluctant radical decarboxylation of small-strained cycloalkanes.}, archive = {J_ANGEW}, author = {Rahul Giri and Po-Kai Peng and Anthony J. Fernandes and Shijin Yu and Julian G. West and Dmitry Katayev}, doi = {10.1002/anie.202508377}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508377}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Overcoming challenges in small-ring transfer: Direct decarboxylative hydroalkylation of alkenes via iron-thiol catalysis}, volume = {64}, year = {2025}, }
• (2025). Length ratio-driven configurational modulation of heteroleptic Pd6L6L’6 cages. ANGEW, 64(34), e202508367. (www)

  @article{ , abstract = {Biomolecular configurational modulation is essential for maintaining the stability and functionality of biological systems. Drawing inspiration from this natural phenomenon, we present a strategy to modulate the configurations of heteroleptic Pd 6 L 6 L' 6 cages by systematically varying the ligand length ratio ( r ). Although theoretical analysis suggests that these Pd 6 L 6 L' 6 assemblies could adopt up to 48 possible configurational isomers, we successfully modulated the thermodynamic preference between two dominant configurations (Type-A and Type-B) by implementing energetic differentiation through careful optimization of r . Specifically, the system exclusively forms Type-A cages at r = 1.0, whereas Type-B becomes the predominant configuration when r ≥ 1.4. Control experiments demonstrate that the introduction of bulky steric groups does not induce configuration changes. This research offers valuable insights and serves as a useful reference for the design and configurational modulation of heteroleptic cages.}, archive = {J_ANGEW}, author = {Ziteng Guo and Hao Yu and Ningxu Han and Xinrui Zhang and Junjuan Shi and Ming Wang}, doi = {10.1002/anie.202508367}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508367}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Length ratio-driven configurational modulation of heteroleptic Pd6L6L’6 cages}, volume = {64}, year = {2025}, }
• (2025). Surface engineering of hollow microreactors with catalytic nanobrushes for orthogonal tandem catalysis. ANGEW, 64(34), e202508249. (www)

  @article{ , abstract = {Micro/nanoreactors with hollow structures have traditionally focused on the design of the internal catalytic microenvironment, while precise engineering of their external surfaces at a nanoscale level is particularly rare. Here, we develop a unique approach to elaborately engineer the surface of zeolitic imidazolate frameworks (ZIF-8)-based hollow microreactor with fluff-like nanostructures that serve as an external catalytic platform. This involves the anchoring of high-density micellar brushes onto the epidermis of ZIF-8 via surface-initiated living crystallization-driven self-assembly, followed by the rapid capture of multiple species to fabricate the catalytic nanobrushes. Such a nanoscale fluff-like surface in combination with an internal cavity that encapsulates other functional components enables specific spatial isolation of various catalysts. The resultant microreactor with external PW 12 nanobrushes for esterification and internal Pt─Ni alloys for hydrogenation reveals prominent activity toward a tandem conversion of p -nitrobenzoic acid into benzocaine with a high selectivity of 95.4%. Remarkably, the microreactor decorated with PW 12 nanobrushes can greatly prompt the catalytic efficiency of esterification with the inhibited competition from the hydrogenation reaction. Overall, this work provides an innovative guidance for the rational creation of multifunctional microreactors with fine surface nanostructures.}, archive = {J_ANGEW}, author = {Shuang Wang and Yujie Wang and Bin Fang and Shunan Zhang and Haozhi Zhou and Yao Lu and Chengshuo Shen and Huibin Qiu}, doi = {10.1002/anie.202508249}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508249}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface engineering of hollow microreactors with catalytic nanobrushes for orthogonal tandem catalysis}, volume = {64}, year = {2025}, }
• (2025). Titanium–Polyoxometalate crosslinked Metallo–Supramolecular polymer as artificial interfacial layer for highly persistent and Low–Temperature tolerant lithium metal batteries. ANGEW, 64(34), e202508224. (www)

  @article{ , abstract = {The uncontrolled lithium (Li) dendrite growth and fragile native solid electrolyte interphase formation have severely hindered the practical development of Li metal batteries. Herein, a coordinatively cross-linked metallo-supramolecular polymer as anodic interfacial protective layer (MSP-IPL) is developed by utilizing titanium(IV)–polyoxometalates (Ti-POMs) as hexatopic linkers to bridge organic and inorganic moieties. The constructed MSP-IPL possesses high electrochemical stability, superior ion-transfer ability, and good air stability. Due to its high film formation uniformity and mechanical tenacity, the MSP-IPL can effectively avoid nonuniform Li deposition caused by the tip effect, thus inhibiting Li dendrite proliferation. The uniformly distributed Ti-POMs in polymer skeleton can efficiently bind with PF 6 − anions, thus increasing Li + transference number and promoting homogeneous Li + distribution. The reprocessability and self-healing ability endowed by dynamic coordination bonds enable the MSP-IPL to accommodate electrode volume changes and maintain good interface contact. Consequently, high-loading Li||LiFePO 4 and Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 batteries based on MSP-IPL-coated Li anodes demonstrate impressive cyclability and extraordinary rate capability. Even at a low temperature of −20 °C, the MSP-IPL-coated Li||NCM811 batteries can still cycle stably for over 500 cycles (equivalent to 138 days) with a considerable capacity retention of 86.8%. This work presents a promising solution for developing practical low-temperature Li metal batteries.}, archive = {J_ANGEW}, author = {Yaoda Wang and Pei-Chen Zhao and Jingjie Sun and Junchuan Liang and Tianyu Shen and Cheng-Hui Li and Zhong Jin}, doi = {10.1002/anie.202508224}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508224}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Titanium–Polyoxometalate crosslinked Metallo–Supramolecular polymer as artificial interfacial layer for highly persistent and Low–Temperature tolerant lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Tunable oxygen vacancy clusters enhanced catalytic activity of CeO2 nanorods on CO2 cycloaddition. ANGEW, 64(34), e202508217. (www)

  @article{ , abstract = {Constructing heterogeneous halogen-free catalysts featuring efficiently activated CO 2 and epoxides for the synthesis of cyclic carbonates via an atom-economical route is significant but remains a big challenge. In this work, we develop an atmosphere-assisted strategy for preparing mesoporous CeO 2 nanorods with tunable oxygen vacancy cluster concentrations, which boosts the performance of CO 2 cycloaddition. Pair distribution function (PDF) analysis elucidates that oxygen vacancy clusters regulate the dynamic equilibrium of the multiscale structure of CeO 2 via a synergistic “compression-expansion” mechanism. Furthermore, the high concentrations of oxygen vacancy clusters form abundant frustrated Lewis pairs (FLP) sites, which remarkably promote the adsorption and activation of CO 2 with epoxides. Thus, the performance of CO 2 cycloaddition was substantially intensified. A 95% yield of cyclic carbonate was obtained when the reaction was conducted with RNR-CeO 2 -H 2 at 110 °C. Moreover, the kinetic properties and the catalytic mechanism of CO 2 cycloaddition on FLP sites in RNR-CeO 2 -H 2 were investigated based on the in situ DRIFTS and DFT calculations. Thus, this work provides new insights into the design of high-performance catalysts with tunable FLP sites for the efficient activation and conversion of CO 2 into value-added chemicals by modulating oxygen vacancy cluster concentrations.}, archive = {J_ANGEW}, author = {Guangcai Long and Andi Wang and Xian Liu and Xuehui Li and Meixuan Liu and Yong Liu and Jinxing Long}, doi = {10.1002/anie.202508217}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508217}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tunable oxygen vacancy clusters enhanced catalytic activity of CeO2 nanorods on CO2 cycloaddition}, volume = {64}, year = {2025}, }
• (2025). Divergent upcycling of polystyrene into phenol and hydroquinone derivatives by photocatalysis and electrocatalysis. ANGEW, 64(34), e202508166. (www)

  @article{ , abstract = {The selective upcycling of polystyrene (PS) waste into value-added aromatics has emerged as a compelling strategy toward sustainable plastic valorization, drawing significant scientific and industrial interest. While most existing methods involved oxidative C─C bond cleavage predominantly yield benzoic acid, the direct conversion of waste PS into phenolic compounds remains largely unexplored. Herein, we report the first example of photocatalytic upcycling of PS into phenol derivatives with high chemoselectivity. This economical method proceeds under ambient conditions (1 atm air and room temperature) using an inexpensive organic photocatalyst via photooxidation-induced Hock rearrangement in a single step. The use of strong acid effectively suppresses the formation of benzoic acid, playing a critical role in high selectivity. Experimental and density functional theory (DFT) calculations revealed that the cis configuration of neighboring phenyl rings in PS raises the barrier for hydrogen atom transfer (HAT) from the benzylic C─H bond, thereby contributing to the low polymer conversion. Furthermore, the novel divergent upcycling of PS to hydroquinone derivatives was achieved by a photo-electro tandem strategy. The practicality of this strategy is demonstrated by depolymerization of real-life PS using a sunlight-driven photocatalytic and electrocatalytic degradation platform, underscoring its promising potential for sustainable and scalable upcycling of PS waste.}, archive = {J_ANGEW}, author = {Shu-Fan He and Tianyi Xu and Qinhui Wan and Kai Tang and Xiangyang Chen and Daixi Li and Yong Jiang and Cai Zhai and Chen Zhu and Tao Shen}, doi = {10.1002/anie.202508166}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508166}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent upcycling of polystyrene into phenol and hydroquinone derivatives by photocatalysis and electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Origin of anion-rich solvation structures in siloxane electrolytes. ANGEW, 64(34), e202508152. (www)

  @article{ , abstract = {High-voltage lithium (Li) metal batteries (LMBs) are promising next-generation high-energy-density rechargeable batteries. Siloxane electrolytes exhibit excellent performance in high-voltage LMBs. Herein, the mechanisms responsible for the Li metal compatibility and high-voltage resistance of siloxane electrolytes were probed by classical molecular dynamics (MD) simulations, first-principles calculations, and experimental characterizations. Siloxane electrolytes have been demonstrated to deliver anion-rich solvation structures, which are induced by weak Li ion (Li + )–solvent interactions and strong Li + –anion interactions. The silicon (Si)─oxygen (O) bond energy of siloxane is larger than that of carbon (C)─O of C-siloxane (replacing Si atoms in siloxane with C atoms) because the atomic radius of Si is larger than that of C, and the Pauli exclusion of Si is smaller than that of C. Additionally, ab initio molecular dynamics (AIMD) simulations revealed that the decomposition of siloxane produces substances containing Si─O fragments on Li metal surfaces, which is beneficial for interfacial stability. This work reveals the mechanism of interfacial stability and intrinsic stability of siloxane electrolytes, providing a theoretical basis for the practical application of siloxane electrolytes in high-voltage LMBs.}, archive = {J_ANGEW}, author = {Yao-Peng Chen and Yi-Lin Niu and Zhao Zheng and Xiang Chen and Yu-Chen Gao and Nan Yao and Rui Zhang and Qiang Zhang}, doi = {10.1002/anie.202508152}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508152}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Origin of anion-rich solvation structures in siloxane electrolytes}, volume = {64}, year = {2025}, }
• (2025). Decoupling activity-selectivity trade-off in photothermal catalytic CO2 hydrogenation: A hydrogen spillover-assisted dual-site synergy mechanism. ANGEW, 64(34), e202508090. (www)

  @article{ , abstract = {The persistent trade-off between catalytic activity and selectivity remains a critical barrier to efficient CO 2 valorization. Herein, we propose a concept of decoupling the activity-selectivity trade-off in the photothermal catalytic reverse water-gas shift (RWGS) reaction by hydrogen spillover-assisted dual-site synergy. This concept is demonstrated through a hybrid catalyst constructed by immobilizing abundant Ru single sites and trace Ru clusters onto high-efficiency photothermal support of N-doped hierarchical carbon nanocages (hNCNC). Theoretical calculations reveal that the Ru─N 4 sites are highly active and selective for the RWGS reaction, contingent on the efficient migration of dissociated *H species to adjacent C atoms of Ru. Importantly, we experimentally confirm that Ru single sites dominate CO 2 hydrogenation to CO, whereas Ru clusters facilitate H₂ activation and supply hydrogen species to adjacent single sites via spillover over hNCNC. Leveraging this synergistic interaction, the hybrid catalyst achieves an exceptional CO production rate of 3.1 mol·g Ru −1 ·h −1 and selectivity over 98%. This mechanism shows universal applicability as demonstrated by the effective promotion of CO 2 hydrogenation of Ru single sites by other typical hydrogen-spillover-active metal clusters, e.g., Pt and Pd clusters. This design concept liberates the potential to overcome the longstanding activity-selectivity trade-off in hydrogenation reactions.}, archive = {J_ANGEW}, author = {Zi-Xuan Sun and Changkai Zhou and Zhijie Chen and Yu Zeng and Tao Sun and Xudong Dong and Lijun Yang and Xizhang Wang and Qiang Wu and Hongwen Huang and Le He and Zheng Hu}, doi = {10.1002/anie.202508090}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508090}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoupling activity-selectivity trade-off in photothermal catalytic CO2 hydrogenation: A hydrogen spillover-assisted dual-site synergy mechanism}, volume = {64}, year = {2025}, }
• (2025). Tunable Endo/Exo selectivity in direct catalytic asymmetric 1,3-dipolar cycloadditions with polyfunctional lewis acid / Azolium–Aryloxide catalysts. ANGEW, 64(34), e202508024. (www)

  @article{ , abstract = {Catalytic asymmetric 1,3-dipolar cycloadditions (1,3-DCA) using iminoesters as ylide precursors offer a powerful approach to accessing stereochemically complex, biologically relevant pyrrolidines. Although previous studies have already achieved impressive stereoselectivities, catalytic productivity remains a challenge, with turnover numbers (TON) typically below 20. In this article, we introduce a novel concept for catalytic 1,3-DCA that enables remarkable productivity for both endo (TON up to 4000) and the more challenging exo products (TON up to 1500). This approach, making use of modular polyfunctional Lewis acid/azolium-aryloxide catalysts, allows for precise control over endo - and exo -diastereoselectivity. The switch from endo - to exo -selectivity is accomplished by modifying the metal center, the azolium moiety, and steric factors. As detailed DFT studies reveal, both the endo - and exo -selective catalyst systems exhibit an almost perfect spatial alignment of their key functional sites, allowing for a unique interplay of Brønsted acids and bases, Lewis acids, and hydrogen bonding. The computational studies further demonstrate that these polyfunctional catalysts dramatically lower the energetic barriers of the concerted or stepwise cycloaddition key steps. However, they also precisely orchestrate and accelerate all accompanying transformations—reminiscent of enzymatic machineries.}, archive = {J_ANGEW}, author = {Adrian Bürstner and Patrick M. Becker and Alexander Allgaier and Lucca Pfitzer and Daniel M. Wanner and Johanna Dollinger and Felix Willig and Justin Herrmann and Vukoslava Miskov-Pajic and Andreas C. Hans and Wolfgang Frey and Joris van Slageren and Johannes Kästner and René Peters}, doi = {10.1002/anie.202508024}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202508024}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tunable Endo/Exo selectivity in direct catalytic asymmetric 1,3-dipolar cycloadditions with polyfunctional lewis acid / Azolium–Aryloxide catalysts}, volume = {64}, year = {2025}, }
• (2025). Divergent asymmetric synthesis of bonnadiene and ent-polytrichastrene b. ANGEW, 64(34), e202507961. (www)

  @article{ , abstract = {We report herein the first asymmetric total synthesis of bonnadiene and ent -polytrichastrene B, two diterpenoids that share a common spirotricyclic skeleton. Notably, ent -polytrichastrene B also features a highly strained, sterically congested tetrasubstituted cyclopropane moiety, presenting significant synthetic challenges in both its construction and stereochemical control. The synthesis features: (1) palladium-catalyzed enantioselective redox-relay Heck alkenylation between electron-withdrawing alkenyl triflate and primary alkenol to form the stereocenter at C7; (2) diastereoselective intramolecular [5+2] cycloaddition to rapidly assemble the unique [6,7,5] spirotricyclic skeleton; (3) sequential installation of the requisite alkyl groups and alkenes present in the targeted molecule by leveraging the functionalities positioned on the tricycle; (4) Fe-catalyzed hydrogen atom transfer (HAT)-initiated hydrogenation to stereospecifically reduce the tetrasubstituted Δ 10,11 olefin and install the contiguous stereocenters; (5) Fe-mediated HAT-initiated 3- exo - trig radical cyclization to rapidly forge the tetrasubstituted cyclopropane ring with excellent stereoselectivity.}, archive = {J_ANGEW}, author = {Hui Wang and Lihua Wei and Jiayu Huang and Linsheng Wang and Haobo Peng and Huanfeng Jiang and Jian Wu and Zhiqiang Ma}, doi = {10.1002/anie.202507961}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507961}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent asymmetric synthesis of bonnadiene and ent-polytrichastrene b}, volume = {64}, year = {2025}, }
• (2025). Resiquimod-induced nanovaccine (RINV) for personalized cancer immunotherapy. ANGEW, 64(34), e202507902. (www)

  @article{ , abstract = {Cancer nanovaccines have emerged as a promising modality for cancer immunotherapy due to their capability of eliciting robust tumor-specific immune responses. However, structural complexity and insufficient spatiotemporal coordination of immune activation pose substantial challenges for optimizing the therapeutic potential of nanovaccines. Herein, a resiquimod-induced nanovaccine (RINV) is devised for personalized cancer immunotherapy. Toll-like receptor (TLR) 7/8 agonist resiquimod (R848) was covalently conjugated to fifth-generation polyamidoamine (G5-PAMAM) dendrimer through a disulfide linker to obtain the vaccine carrier G5-R848. In this design, R848 not only fulfills its biological role as a vaccine adjuvant but facilitates uniform nanovaccine formation with the model protein antigen ovalbumin (OVA) due to its distinctive chemical structure. Redox-triggered intracellular R848 release further promotes cytosolic delivery of antigen and subsequent antigen cross-presentation. In vivo studies demonstrated that the nanovaccine induces remarkable prophylactic and therapeutic effects in the B16F10-OVA melanoma model. Moreover, G5-R848 forms personalized nanovaccines by complexing with cell lysates from resected B16F10 and 4T1 tumor tissues, effectively inhibiting postoperative tumor recurrence and metastasis.}, archive = {J_ANGEW}, author = {Wei Xu and Jia-Qi Luo and Shi-Yu Wang and Zhen-Lin Gao and Feng-Qin Luo and Xin Zhang and Kai-Shuo Wang and Juan Du and Zhi-Liang Ji and Jin-Zhi Du and Jun Wang}, doi = {10.1002/anie.202507902}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507902}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Resiquimod-induced nanovaccine (RINV) for personalized cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Controlling assembly of hybrid DNA nanostructures into higher-order structures via hydrophobicity. ANGEW, 64(34), e202507844. (www)

  @article{ , abstract = {Hydrophobic interactions are one of the fundamental driving forces of self-assembly in living systems. It remains challenging to harness hydrophobicity to have a controllable and programmable assembly of DNA nanostructures. On the other hand, there is also a need to explore orthogonal hierarchical assembly strategies to be used as an additional toolset along with the traditional Watson–Crick base pairing to achieve complex superstructures. In this work, we rationally design and synthesize a series of low molecular weight hydrophobic molecules that are conjugated to single-stranded DNA strands. By incorporating these modified DNA strands into the precisely defined locations of DNA tiles and origami nanostructures, we achieve controlled hierarchical assembly driven by hydrophobic interaction. We demonstrate a versatile hydrophobicity-guided higher-order assembly strategy by employing strategically engineered DNA nanostructures of increasing complexity, ranging from simple DNA tiles to complex origami structures, functionalized with these small hydrophobic molecules as programmable building blocks.}, archive = {J_ANGEW}, author = {Minu Saji and Devanathan Perumal and Qi Yang and Frieder Jaekle and Fei Zhang}, doi = {10.1002/anie.202507844}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507844}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlling assembly of hybrid DNA nanostructures into higher-order structures via hydrophobicity}, volume = {64}, year = {2025}, }
• (2025). A butterfly-like fluorescent tracker for dynamic polymers. ANGEW, 64(34), e202507770. (www)

  @article{ , abstract = {Optically tracking constitutional dynamics provides a time-resolved, non-invasive, and visually interpretable approach to unraveling microscopic complexity in system chemistry. Here we report a butterfly-like fluorescent tracker, featuring excited-state conformational adaptivity, capable of sensing the subtle microscopic dynamics of polymers as a ratiometric fluorescent probe. The key design is coupling the fluorophore's conformational relaxation dynamics to microenvironmental constraints imposed by polymer structural features—such as chain length, conformation, and inter-/intramolecular interactions. By employing the fluorophore as a bifunctional initiator, we grafted two dynamic polymer chains onto its phenyl “wings”, creating a single-fluorophore tracker that dynamically interacts with its environment. This system functions as a highly sensitive ratiometric probe, optically reporting microscopic polymer dynamics in real time, including polymerization kinetics, chain folding/unfolding transitions, and depolymerization processes. Systematic studies demonstrate the broad applicability of this concept across diverse polymeric systems, with distinct emission signatures enabling differentiation between systems. The probe's ability to correlate fluorescence output with microenvironmental changes reveals its utility in both fundamental and applied contexts. We anticipate this conformationally adaptive fluorescent platform will advance research in dynamic chemistry, particularly for real-time monitoring of polymeric systems and the development of responsive materials.}, archive = {J_ANGEW}, author = {Shudong Zheng and Minyi Ma and Da-Hui Qu and He Tian and Qi Zhang}, doi = {10.1002/anie.202507770}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507770}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A butterfly-like fluorescent tracker for dynamic polymers}, volume = {64}, year = {2025}, }
• (2025). Biosynthesis of the red algal diterpene peyssonnosol in bacteria. ANGEW, 64(34), e202507752. (www)

  @article{ , abstract = {Two diterpene synthases (DTSs) for peyssonnosol and peyssonnosol B were discovered in bacteria. Their enzyme mechanisms were investigated through isotopic labelling experiments, density functional theory (DFT) calculations and site-directed mutagenesis, yielding biosynthetically related molecules that gave important insights into the terpene cyclisation cascade. In the present case, several mechanisms in line with the isotopic labelling experiments could be formulated. Only an extended experimental approach in combination with computational chemistry ultimately resulted in a refined mechanistic model.}, archive = {J_ANGEW}, author = {Zhiyong Yin and Zhehui Hu and Kexin Yang and Guihu Lu and Georges B. Tabekoueng and Pingping Wu and Qi Luo and Juan Xu and Bernd Goldfuss and Jeroen S. Dickschat and Guangkai Bian}, doi = {10.1002/anie.202507752}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507752}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biosynthesis of the red algal diterpene peyssonnosol in bacteria}, volume = {64}, year = {2025}, }
• (2025). Donor–Acceptor porous aromatic framework cathode with fast redox kinetics for ultralow-temperature (−70 °C) potassium-organic batteries. ANGEW, 64(34), e202507570. (www)

  @article{ , abstract = {Low-temperature rechargeable batteries are essential for cryogenic energy storage. However, lowering the working temperature will exacerbate the disadvantages of slowed reaction kinetics and mechanical instability of inorganic electrode materials, thus causing severe capacity degradation. In this work, for the first time, we demonstrated that constructing a donor–acceptor (D–A) porous aromatic framework (PAF-310) using p-type phenazine (PZ) and n-type hexaazatrinaphthylene (HATN) as storage blocks can accelerate charge transport and thus facilitate the reaction kinetics even at low-temperature conditions. When employed as the cathode of potassium ion batteries (PIBs), PAF-310 possesses higher electrochemical performance than its counterparts, including impressive discharge specific capacity (215.6 mAh g −1 at 0.2 A g −1 ) and outstanding rate performance (77.8 mAh g −1 at 50 A g −1 ) at 25 °C. Furthermore, PAF-310 also delivers impressive specific capacities in low-temperature conditions (168.2 mAh g −1 at −20 °C and 130.1 mAh g −1 at −40 °C at 0.2 A g −1 ). Even at −70 °C, PAF-310 still exhibits good specific capacity (102.2 mAh g −1 at 50 mA g −1 ). Moreover, various in/ex-situ spectral characterizations and theoretical calculations were employed to elucidate the continuous co-storage mechanism of K + and PF 6 − in PAF-310. This contribution sheds a feasible molecular design strategy towards low-temperature stabilized PIBs.}, archive = {J_ANGEW}, author = {Jie Yu and Xupeng Zhang and Yuying Liu and Linqi Cheng and Heng-Guo Wang and Fengchao Cui and Guangshan Zhu}, doi = {10.1002/anie.202507570}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507570}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Donor–Acceptor porous aromatic framework cathode with fast redox kinetics for ultralow-temperature (−70 °C) potassium-organic batteries}, volume = {64}, year = {2025}, }
• (2025). Ligand-controlled chemoselectivity in the rhodium-catalyzed synthesis of pentafulvenes via (2 + 2 + 1) alkyne cyclotrimerization. ANGEW, 64(34), e202507424. (www)

  @article{ , abstract = {The synthesis of pentafulvenes with varied substituents has been efficiently achieved using novel rhodium-based catalysts via (2 + 2 + 1) alkyne cyclotrimerization. A rational design of the catalyst structure, including pyridonato, NHC, and CO ligands, ensures the alkyne chemoselectivity and prevents the formation of robust rhodium-fulvene species. Furthermore, the judicious choice of acidity and steric properties of different alkynes enables the preparation of cross-coupled fulvene derivatives. Stoichiometric and deuteration experiments, as well as DFT calculations, shed light on the reaction mechanism, showing that it includes an initial alkyne deprotonation, two successive alkyne insertions, cyclization, and protonolysis, the first insertion being the rate-determining step.}, archive = {J_ANGEW}, author = {Belinda Español-Sánchez and Jesús Moradell and María Galiana-Cameo and Eduardo Barrenas and Jesús J. Pérez-Torrente and Vincenzo Passarelli and Ricardo Castarlenas}, doi = {10.1002/anie.202507424}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-controlled chemoselectivity in the rhodium-catalyzed synthesis of pentafulvenes via (2 + 2 + 1) alkyne cyclotrimerization}, volume = {64}, year = {2025}, }
• (2025). Engineered C–N lyases for stereoselective synthesis of tertiary amines. ANGEW, 64(34), e202507311. (www)

  @article{ , abstract = {Optically pure N -functionalized α-amino acids are valuable chiral building blocks for pharmaceuticals, nutraceuticals, and agrochemicals. Ethylenediamine- N,N -disuccinic acid lyase from Chelativorans sp. BNC1 catalyzes the addition of a wide range of aliphatic and aromatic primary amines to fumarate, producing the corresponding enantioenriched N -substituted L- aspartic acids. In this work, the enzyme was subjected to iterative cycles of site-saturation mutagenesis and screened for increased activity for the addition of 2-((methylamino)methyl)aniline to fumarate. The final variant displayed an activity of three orders of magnitude higher compared to the wild-type enzyme. Unexpectedly, the enzyme catalyzed the hydroamination of fumarate with the aliphatic secondary amine of the starting substrate, rather than with the aromatic primary amine, leading to the formation of a tertiary amine. Exploring the substrate scope showed that the enzyme accepts various substituted N -methyl-1-phenylmethanamines for the hydroamination of fumarate, yielding N,N -disubstituted L -aspartic acids in high optical purity (up to >99% ee). Furthermore, we showed that the enzyme accepts several ortho -substituted anilines that were previously not accepted by the wild-type enzyme, yielding the corresponding N -arylated L -aspartic acids in high enantiomeric excess (>99% ee). This serendipitous finding enables a new strategy for the biocatalytic synthesis of tertiary amines, unlocked within the C-N lyase toolbox.}, archive = {J_ANGEW}, author = {Laura Bothof and Xiaofang Gong and Marrit E. Onclin and Peter Fodran and Gerrit J. Poelarends}, doi = {10.1002/anie.202507311}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507311}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered C–N lyases for stereoselective synthesis of tertiary amines}, volume = {64}, year = {2025}, }
• (2025). Hybrid cathode interlayer engineering enables over 20% efficiency of organic solar cells. ANGEW, 64(34), e202507294. (www)

  @article{ , abstract = {The capability of cathode interlayer (CIL) in regulating the conductivity, interfacial dipole, and work function of the electrode plays a critical role in determining the photovoltaic performance of organic solar cells (OSCs). The widely used perylene-diimide-based CILs suffered from the inbuilt limitation of finite conductivity and poor thickness tolerance. To address this issue, we develop a universal strategy to finely optimize the functionality of perylene-diimide-type CIL (PDINN) by incorporating polyfluorine-substituted copper phthalocyanine (CuPc) derivative to form a hybrid CIL. It is found that the hydrogen bonding and π–π interaction between PDINN and CuPc can address the solvent processability issue of CuPc used as CIL. The incorporation of CuPc in the PDINN layer leads to better film morphology, increased conductivity, and reduced cathode work function, enabling greater CIL thickness tolerance and significantly improved photovoltaic performance of OSCs. Notably, the PM6:D18:L8-BO-based device using PDINN:F16CuPc as hybrid CIL yields a remarkable power conversion efficiency (PCE) of 20.17%, which is a significant improvement with regard to the PCE of 19.29% for the control device based on PDINN CIL. Particularly, this strategy demonstrates a universality in multiple photoactive layers and various perylene-diimide-based CILs, offering an effective approach to developing highly efficient OSCs.}, archive = {J_ANGEW}, author = {Hang Yang and Wenjing Zhang and Xiaoxiao Li and Ya Yuan and Yue Wu and Xiaoying Xiong and Chaohua Cui and Yongfang Li}, doi = {10.1002/anie.202507294}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507294}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hybrid cathode interlayer engineering enables over 20% efficiency of organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Polyolefin-based multiblock copolymers from cascade ROMP-RAFT polymerization. ANGEW, 64(34), e202507257. (www)

  @article{ , abstract = {Plastic disposal has become a serious environmental and social problem. Mechanical recycling of waste plastics is the most widely adopted strategy to address this issue, but if used to recycle mixed plastics, it usually requires the addition of amphiphilic block copolymers. Polyolefins account for almost half of all synthetic plastics, making them ubiquitous in the plastic waste stream. Within this perspective, polyolefin-based multiblock copolymers are highly desirable, but they are difficult to access using traditional strategies. In this contribution, a cascade ring-opening metathesis polymerization (ROMP) and reversible addition-fragmentation chain transfer (RAFT) polymerization strategy was developed to prepare various polyolefin-based multiblock copolymers with tunable polar segments and microstructures. Using this strategy, tunable amounts of the trithiocarbonate RAFT agents were installed in the polyolefin main chain via ROMP. Subsequent chain extension of various polar vinyl monomers via controlled RAFT polymerization formed various polyolefin-based multiblock copolymers with high molecular weight and good physical properties. These multiblock copolymers were used to compatibilize and upcycle mixtures of high-density polyethylene/polymethyl methacrylate (HDPE/PMMA) and high-density polyethylene/polyethylene terephthalate (HDPE/PET).}, archive = {J_ANGEW}, author = {Min Chen and Guifu Si and Wen-Jian Zhang and Changle Chen}, doi = {10.1002/anie.202507257}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507257}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyolefin-based multiblock copolymers from cascade ROMP-RAFT polymerization}, volume = {64}, year = {2025}, }
• (2025). Redox- and NIR-active Iron(III) triradicals as catalysts for radical polymerization of acrylamides and methacrylates. ANGEW, 64(34), e202507231. (www)

  @article{ , abstract = {Two unprecedented redox-active, low-spin Fe(III)-triradical complexes, [Fe(III)(SS-NHC═S •− ) 3 ]·NHC═S ( 1 ·NHC═S; E═S) and [Fe(III)(SS-NHC═Se •− ) 3 ] ( 2 ; E═Se) have been synthesized and structurally characterized by SCXRD. They were further characterized spectroscopically using IR, Raman, EPR, and UV–vis-NIR spectroscopy. The low-spin electronic configuration of the central Fe(III) ion ( 1 ) and the nature of the magnetic interaction between the Fe(III) center and the three unpaired electrons in 1 have been investigated by magnetic measurements. In addition, the bonding stability and electron density distribution in 1 were studied by quantum chemical calculations and correlated with experimental results. Finally, a series of well-defined functional homopolymers were synthesized via catalytic polymerization reactions using [Fe(III)(SS-NHC═S •− ) 3 ] ( 1 ) as a catalyst at ambient temperature. These reactions yielded poly( N , N -dimethylacrylamide) (PDMA), poly( N -isopropyl acrylamide) (PNIPAM), poly(dimethyl amino ethyl methacrylate) (PDMAEMA), and poly(benzyl methacrylate) (PBzMA) with low dispersities ranging from 1.2 to 1.22. The successful synthesis of various diblock copolymers confirmed excellent chain-end fidelity of the synthesized homopolymers. These homopolymers and diblock copolymers highlight the versatile catalytic polymerization reactions of these Fe-radical complexes. Herein, we present a report on the polymerization of various acrylamides and methacrylates using a redox-active Fe-dithiolene complex for the first time.}, archive = {J_ANGEW}, author = {Sujit Das and Amul Jain and Subuhan Ahamed and Bhanendra Sahu and Sonam Suthar and Björn Schwarz and Christel Livia Mascarenhas and Sangita Mondal and Saroj Kumar Kushvaha and Sanjib Banerjee and Herbert W. Roesky and Kartik Chandra Mondal}, doi = {10.1002/anie.202507231}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202507231}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox- and NIR-active Iron(III) triradicals as catalysts for radical polymerization of acrylamides and methacrylates}, volume = {64}, year = {2025}, }
• (2025). MXene-supported Ru–Ni: A common active site for hydrolysis, hydrogen oxidation, and hydrogenation. ANGEW, 64(34), e202506869. (www)

  @article{ , abstract = {Insights into the activation and conversion of hydrogen using a single-mode catalyst are crucial for advancing fuels and fine chemical production. In this paper, the activation and conversion of H 2 molecules in hydrogen production and application were investigated on RuM (M = Ni, Co, Cu, Fe)-MXene catalysts. RuM (M = Ni, Co, Cu, Fe) bimetallic nanoclusters were uniformly distributed on Ti 3 C 2 MXene. The optimal Ru 2.5 Ni 2.5 -Ti 3 C 2 exhibits the highest turnover frequency (TOF) value of 1833 min −1 toward ammonia borane (AB, NH 3 BH 3 ) hydrolysis. Meanwhile, the catalysts also showed good catalytic activity in hydrogen oxidation reaction (HOR) and phenylacetylene hydrogenation. The high activity originates from the acceleration of the catalytic process by RuNi clusters-Ti 3 C 2 and the promotion of H 2 molecular transport by the special interface of RuNi cluster-MXene. The RuNi clusters—Ti 3 C 2 with multisites provide a dependable platform for the regulated activation and conversion of H 2 molecules and various reaction intermediates. The competitiveness of nanocluster-MXene catalytic material is showcased for activation and conversion of hydrogen. This research of reaction-inducing adaptation uncovered the pathway to explore multifunctional catalysts in energy, chemistry, and materials applications.}, archive = {J_ANGEW}, author = {Shuyan Guan and Yanyan Liu and Shuling Liu and Zechao Zhuang and Ruofan Shen and Huanhuan Zhang and Erjun Liang and Yanping Fan and Jianchun Jiang and Baozhong Liu and Yongfeng Wang and Dingsheng Wang and Baojun Li}, doi = {10.1002/anie.202506869}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {MXene-supported Ru–Ni: A common active site for hydrolysis, hydrogen oxidation, and hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Sequential reconstruction of calicheamicin γ1I iodo-thiobenzoate by selective carrier protein trapping reveals a flavin-dependent iodinase. ANGEW, 64(34), e202506825. (www)

  @article{ , abstract = {Flavin-dependent halogenases (FDHs) play important roles in natural product biosynthesis, particularly chlorinases and brominases. Apart from ubiquitous mammalian iodination in thyroxine biosynthesis, iodinated natural products are extremely rare, and enzymes responsible for iodination are even less well described. A notable exception is calicheamicin γ 1 I , a potent antitumor compound containing an aromatic iodide, for which a halogenase has been proposed to mediate iodine incorporation. Despite predictions regarding the enzymes involved in iodinated aryl ring biosynthesis, experimental evidence remains limited due to challenges in substrate identification and reaction monitoring. In this study, we successfully reconstituted the enzymatic activities required for iodination and all embellishments of the highly substituted benzene ring in calicheamicin γ 1 I . Using intact-protein mass spectrometry combined with protease cleavage, we demonstrated formation of the orsellinate thioester followed by sequential C-2 O -methylation, C-5 iodination, C-3 oxidation, and C-3 O -methylation. This research characterizes the first flavin-dependent iodinase that acts on a carrier protein-dependent substrate, identifies the natural substrates of a cytochrome P450 oxygenase and two O -methyltransferases, and provides valuable insights for biocatalysis. Additionally, these findings could facilitate the engineering of other polyketide biosynthetic pathways and contribute to optimizing fermentation conditions to generate new calicheamicin derivatives.}, archive = {J_ANGEW}, author = {Fang Pang and Craig A. Townsend}, doi = {10.1002/anie.202506825}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506825}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sequential reconstruction of calicheamicin γ1I iodo-thiobenzoate by selective carrier protein trapping reveals a flavin-dependent iodinase}, volume = {64}, year = {2025}, }
• (2025). Intracellular delivery of native proteins by BioReversible arginine modification (BioRAM) on amino groups. ANGEW, 64(34), e202506802. (www)

  @article{ , abstract = {Protein-based tools are emerging as innovative solutions to interfere with biological pathways in molecular biology and medicine. They offer advantages over traditional small molecules due to their adaptable structural diversity and their ability to engage previously inaccessible cellular targets. However, most proteins do not penetrate the lipid bilayer of mammalian cells and are therefore restricted to extracellular targets. Despite recent advances, a general method for the delivery of functional proteins into human cells remains a significant challenge. In this study, we present a bioreversible protein modification strategy of amines using short arginine-containing peptides (termed BioRAM) that enables cytosolic delivery starting from genetically non-engineered proteins. We optimized the bioconjugation strategy to achieve fast intracellular cleavage and complete recovery of the native protein. In combination with our previously established cell-penetrating peptide (CPP)-additive protocol, we show superior delivery of fluorescent protein and functional RNase A into the cytosol, achieving physiological response. Moreover, we are able to demonstrate the excellent performance of BioRAM in the presence of serum, thereby broadening the scope for intracellular applications of functional proteins.}, archive = {J_ANGEW}, author = {Jonathan Franke and Jan Vincent V. Arafiles and Christian Leis and Christian P. R. Hackenberger}, doi = {10.1002/anie.202506802}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506802}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intracellular delivery of native proteins by BioReversible arginine modification (BioRAM) on amino groups}, volume = {64}, year = {2025}, }
• (2025). Highly oxygen-tolerant and self-adaptive surface-initiated bimetal-mediated controlled radical polymerization. ANGEW, 64(34), e202506761. (www)

  @article{ , abstract = {We report herein a self-adaptive surface-initiated bimetal-mediated controlled radical polymerization (SI-BMCRP) for fabricating various polymer brushes using microliter volumes under ambient conditions. The introduction of bimetal CuZn alloy can self-adaptively control the dissociation of copper species while still realizing the controllability of polymer brush growth with high oxygen tolerance at a wide range of distances between the bimetal alloy and the initiator-modified substrate. The successful fabrication of multiscale and multifunctional polymer brushes with high-end group fidelity and patterned architectures further demonstrates the robust nature of SI-BMCRP. The resultant polymer brushes show great potential for new applications in moisture-enabled electricity generation, breath monitoring, and speech recognition.}, archive = {J_ANGEW}, author = {Menglu Chen and Wei Li and Shuai You and Wenbo Sheng and Feng Zhou}, doi = {10.1002/anie.202506761}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506761}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly oxygen-tolerant and self-adaptive surface-initiated bimetal-mediated controlled radical polymerization}, volume = {64}, year = {2025}, }
• (2025). Counterintuitive photochemistry of an isolated acridinyl radical: ConPET via preassembly, solvated electrons or a long-lived excited state?. ANGEW, 64(34), e202506701. (www)

  @article{ , abstract = {Photoredox chemistry has seen a dramatic rise in popularity in recent years, but mechanistic understanding has persistently lagged behind reaction development itself. This is particularly true for the emerging area of consecutive photoinduced electron transfer (conPET), which has attracted both great interest due to its ability to activate inert substrates selectively and under mild conditions and continuing controversy over its mechanistic feasibility. We describe herein the isolation of the key radical intermediate state of an acridinium-based conPET catalyst and detailed investigations of its photochemistry by a suite of (photo)reactivity, photoluminescence and transient absorption techniques, supported by computational studies. We observe strong wavelength and solvent dependencies in the reactivity profile, which correlate well with observations of a long-lived, fluorescent excited state that would be compatible with diffusion-limited reactivity. However, photoluminescence and transient absorption spectroscopies suggest that, counter-intuitively, this state does not actually participate in reactivity. Instead, changes occur far faster than the diffusion limit, which provides strong, direct evidence for preassembly of the photocatalyst and substrate prior to photoexcitation. Further inspection also indicates parallel formation of solvated electrons, likely providing the major pathway under previously reported synthetic conditions, suggesting that otherwise competing rationales for conPET can in fact operate simultaneously.}, archive = {J_ANGEW}, author = {Samuel J. Horsewill and Katherine M. M. Sharrock and Péter P. Fehér and Jack M. Woolley and Imre Pápai and Daniel J. Scott}, doi = {10.1002/anie.202506701}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Counterintuitive photochemistry of an isolated acridinyl radical: ConPET via preassembly, solvated electrons or a long-lived excited state?}, volume = {64}, year = {2025}, }
• (2025). Decoy DNA protects molecular tension probes from DNase degradation. ANGEW, 64(34), e202506590. (www)

  @article{ , abstract = {DNA-based molecular probes are essential tools for visualizing and quantifying mechanotransduction at the single-molecule level. However, their application in live-cell environments is severely limited by DNase-mediated degradation, which shortens probe lifespan and introduces false-positive signals. Here, we present a decoy DNA strategy where an excess of unmodified double-stranded DNA competitively binds DNases, effectively preserving functional DNA probes. This approach extends probe stability from 1–2 h to beyond 24 h, substantially improving signal integrity in live-cell tension imaging. In contrast to structurally modified nucleic acids, decoy DNA can be readily applied to existing DNA probe systems, enabling seamless integration without the need for additional validation or calibration. This cost-effective and scalable strategy provides a generalizable framework for stabilizing DNA-based molecular tools in DNase-rich environments, enabling high-precision mechanobiology studies across diverse cell types and extended experiment durations.}, archive = {J_ANGEW}, author = {Hongyuan Zhang and Seong Ho Kim and Isaac T. S. Li}, doi = {10.1002/anie.202506590}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506590}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoy DNA protects molecular tension probes from DNase degradation}, volume = {64}, year = {2025}, }
• (2025). Bone-inspired sustainable hydrogel electrolytes for zn metal batteries. ANGEW, 64(34), e202506449. (www)

  @article{ , abstract = {Hydrogels are promising electrolytes for use in aqueous Zn metal batteries (AZMBs). However, the problems associated with the Zn anodes cannot be eliminated using current hydrogel electrolytes, and their poor sustainability has also been neglected. We have developed a bone-inspired hydrogel electrolyte (Zn-HA-Gel) composed of Zn-doped hydroxyapatite (Zn-HA) nanofibers and a gelatin matrix derived from animal bones. The bone-like structure and strong molecular interactions in the biodegradable, recyclable, and biocompatible components endow Zn-HA-Gel with excellent sustainability, water retention, and mechanical properties, which solves the problems currently associated with Zn anodes. Moreover, the Zn-HA superionic conductor exhibits an ultrahigh intrinsic ionic conductivity and accelerated Zn 2+ desolvation process. The dual-channels for Zn 2+ transport in Zn-HA-Gel result in high ionic conductivity (32.5 mS cm −1 ) and transference number (0.80), facilitating uniform Zn plating/stripping and durable working stability. As a result, Zn-HA-Gel ensures ultrastable cycling performance with a cumulative capacity of 5 Ah cm −2 at 5 mA cm −2 /5 mAh cm −2 for Zn/Zn cells and a superior cycling performance with a capacity retention of 82.4% after 2000 cycles for full cells, surpassing the capabilities of current hydrogel electrolytes, and has potential applications in sustainable and functional energy-storage devices.}, archive = {J_ANGEW}, author = {Jiaying Peng and Weihao Song and Wei Zhang and Xinyu Li and Qing Ma and Bing Wu and Masatsugu Fujishige and Kenji Takeuchi and Morinobu Endo and Chendong Ji and Yilin Sun and Jin Niu and Feng Wang}, doi = {10.1002/anie.202506449}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506449}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bone-inspired sustainable hydrogel electrolytes for zn metal batteries}, volume = {64}, year = {2025}, }
• (2025). Direct asymmetric α-C addition of glycinate to nitroalkenes by Pyridoxal/Nd dual catalysis. ANGEW, 64(34), e202506342. (www)

  @article{ , abstract = {Direct enantioselective α-C Michael addition of NH 2 -unprotected glycinate to nitroalkenes is a significant organic transformation, which may provide a highly efficient strategy to make bioactive chiral γ-nitro-α-amino acid esters. However, it is extremely challenging to achieve this reaction due to the interference of the reactive NH 2 group, potential [3 + 2] cycloaddition side reaction and complicated stereoselective control. Carbonyl catalysis is an effective strategy to activate glycinate by forming an imine to facilitate the conjugate addition. With a pyridoxal/Nd dual catalytic system, direct asymmetric α-C conjugate addition of glycinate to nitroalkenes has been successfully developed for the first time, producing a broad range of chiral γ-nitro-α-amino acid esters in high yields with excellent stereoselectivities (up to 98% yield, >20:1 dr, 98% ee). The products can be easily converted into various biologically significant chiral molecules maintaining the same enantiopurity.}, archive = {J_ANGEW}, author = {Shibo Si and Qingfang Wang and Yiming Lv and Huifang Liao and Wen-Wen Chen and Siqi Liu and Baoguo Zhao}, doi = {10.1002/anie.202506342}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506342}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct asymmetric α-C addition of glycinate to nitroalkenes by Pyridoxal/Nd dual catalysis}, volume = {64}, year = {2025}, }
• (2025). Integrated chemoenzymatic synthesis of the mRNA vaccine building block n1-methylpseudouridine triphosphate. ANGEW, 64(34), e202506330. (www)

  @article{ , abstract = {Pseudouridine-5′-triphosphate (ΨTP) and its N 1 -methylated derivative (m 1 ΨTP) are critical monomer building blocks of mRNA therapeutics, yet efficient, scalable methods of their synthesis from readily accessible substrates remain underdeveloped. m 1 ΨTP is a major cost factor of production of the current COVID-19 vaccines. We herein report a notably atom-economic and high-yielding biocatalytic route toward ΨTP and present two chemoenzymatic routes for producing m 1 ΨTP at ∼200 mg scale of isolated compound. Biocatalytic cascade rearrangement of uridine delivered ΨMP or Ψ in high yields. Acetonide-protected ΨMP was selectively N 1 -methylated using dimethyl sulfate and subsequently converted to the triphosphate through efficient kinase cascade reaction. Saccharomyces cerevisiae uridine 5′-monophosphate kinase was shown for ATP-dependent phosphorylation of m 1 ΨMP to m 1 ΨDP and m 1 ΨTP synthesis was catalyzed by Escherichia coli acetate kinase which also served to regenerate ATP by acetyl phosphate. Benchmarked against chemical route converting the enzymatically produced Ψ into m 1 ΨTP, the novel chemoenzymatic route from ΨMP offered improved metrics of reaction efficiency and sustainability. The synthetic ΨTP and m 1 ΨTP replaced UTP for mRNA synthesis by in vitro transcription. Overall, this study shows the productive integration of chemical methylation with enzymatic cascade reactions for C─C coupling and phosphorylation toward an efficient preparation of m 1 ΨTP.}, archive = {J_ANGEW}, author = {Martin Pfeiffer and Leo Krammer and Johannes Zöhrer and Rolf Breinbauer and Bernd Nidetzky}, doi = {10.1002/anie.202506330}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506330}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated chemoenzymatic synthesis of the mRNA vaccine building block n1-methylpseudouridine triphosphate}, volume = {64}, year = {2025}, }
• (2025). Cyclo-octasulfur crystals as light-controlled molecular muscles. ANGEW, 64(34), e202506269. (www)

  @article{ , abstract = {Here, we describe the synthesis and photo-responsive properties of 2D cyclo-octasulfur microcrystals (α- S8 MCs), produced using a quick, simple, cost-effective, and environmentally friendly hydrothermal method. Controlled 385-nm irradiation of these crystals induces an immediate, reversible, and sustained bending effect. The time required for the crystals to return to their initial shape is significantly reduced when exposed to 475-nm light, completing the entire excitation-relaxation cycle in less than 2 s. Moreover, this process can be repeated up to 50 times as long as the crystals remain in water. The dependence of recovery time on light wavelength is rationalized qualitatively via highly correlated quantum-chemical calculations of the absorption spectra of S8 chains. The underlying mechanism involves a combination of ring-to-chain and chain-to-ring transformations: the breaking of α- S8 rings by 385-nm radiation induces bending in the α- S8 MCs, while the excitation of the chains with 475-nm light facilitates an accelerated recovery process, allowing the S8 molecules to swiftly regain their ring shape. Thus, our study demonstrates that α- S8 MCs represent intelligent actuators as light-controlled molecular muscles with the simplest inorganic composition reported to date.}, archive = {J_ANGEW}, author = {Enrique Solano-Rodríguez and Qi Sun and Jean-Luc Brédas and Veaceslav Coropceanu and Beatriz Jurado-Sánchez and Alberto Escarpa}, doi = {10.1002/anie.202506269}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyclo-octasulfur crystals as light-controlled molecular muscles}, volume = {64}, year = {2025}, }
• (2025). Introducing steric bulk into silylboranes: Enhanced bench stability and novel chemical reactivity. ANGEW, 64(34), e202506194. (www)

  @article{ , abstract = {Silylboranes are versatile intermediates in organic synthesis, and a wide range of structural variants of silylboranes have already been synthesized. However, the stability of silylboranes varies significantly, and their decomposition mechanism remains to be fully understood. Moreover, some silylborane motifs have not yet been applied as synthetic reagents due to their instability. To address this issue, we first investigated the decomposition mechanism of silylboranes in air and moisture using experimental and theoretical methods. We discovered that oxygenation by atmospheric oxygen is the major decomposition pathway, resulting in the formation of a borylsilylether, and that the introduction of a bulky silyl group suppresses this decomposition. Based on these results, we synthesized triisopropylsilyldimesitylborane ( i- Pr 3 Si–BMes 2 ), which exhibits high bench stability. Moreover, i- Pr 3 Si–BMes 2 reacts with carbon monoxide (CO), which is the first example of a reaction between a silylborane and CO. Further computational studies revealed that electronic effects, including hyperconjugation between the Si─B σ-bond and C─O π*-bond, are crucial for CO activation. Furthermore, we prepared a bench-stable bissilylaminoborane by introducing triisopropylsilyl groups, providing a bissilylchloroborane upon hydrogen chloride treatment. These findings provide valuable insights into how steric and electronic effects can be used to optimize the balance between stability and reactivity in silylboranes.}, archive = {J_ANGEW}, author = {Rikuro Takahashi and Julong Jiang and Satoshi Maeda and Hajime Ito}, doi = {10.1002/anie.202506194}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506194}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Introducing steric bulk into silylboranes: Enhanced bench stability and novel chemical reactivity}, volume = {64}, year = {2025}, }
• (2025). Angularly resolved tip-enhanced raman spectroscopy. ANGEW, 64(34), e202506152. (www)

  @article{ , abstract = {Despite intensive research in tip-enhanced Raman spectroscopy (TERS), the angular distribution of Raman scattering in the TERS gap remains experimentally unreported leaving its relevance to the TERS signal formation to be seldomly discussed. Here, we investigate the angular distribution of the tip-enhanced Raman signal in the Fourier plane using a model system composed of flat-lying cobalt (II) hexadecafluoro-phthalocyanine (CoPcF 16 ) molecules physically adsorbed on a smooth gold surface. Both in-plane and out-of-plane vibrational modes are observed, where the out-of-plane Raman modes at about 678 and 740 cm −1 have different angular intensity distributions than those of in-plane Raman modes at 1309 and 1373 cm −1 . We interpret the angular spectrum of the TERS signal considering the molecular vibrational modes computed with density functional theory (DFT) for the free and gold-deposited molecule, and the directed Raman scattering by the gap-mode predicted by finite-difference time-domain (FDTD) simulations. We contend that the TERS gap directs the Raman vibrational modes differently, leading to distinct angularly distributed Raman scattering intensities. These findings emphasize the nonnegligible role of the TERS detection scheme in understanding spectral features, such as the relative peak intensity ratio variations for studying molecular orientations, or for monitoring chemical reactions.}, archive = {J_ANGEW}, author = {Felix Schneider and Tim Parker and Liangxuan Wang and Michel Rebmann and Yang Zhao and Eric Juriatti and Heiko Peisert and Alfred J. Meixner and Johannes Gierschner and Lingyan Meng and Dai Zhang}, doi = {10.1002/anie.202506152}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506152}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Angularly resolved tip-enhanced raman spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Visible-light-mediated intramolecular dearomatization of naphthalene and anthracene with bicyclo[1.1.0]butanes through energy transfer catalysis. ANGEW, 64(34), e202506073. (www)

  @article{ , abstract = {Cyclization of bicyclo[1.1.0]butanes (BCBs) is an effective way to construct saturated polycyclic 3D structures. Herein we report a visible-light-induced intramolecular dearomative reaction to forge bicyclo[4.1.1] frameworks through (1,3)-cyclization of BCBs. Moreover, the unprecedented (1,2,3)-cyclization of BCBs through 1,4-hydrogen atom transfer (HAT) process was also realized along with the further transformations. The mechanistic studies revealed that the reaction was initially carried out by an energy transfer (EnT) process and the key open-shell singlet biradical intermediate may undergo [4π + 2σ] cycloaddition or 1,4-HAT process leading to the formation of two products and we found that the selectivity of product is related to the substituents at the BCBs bridgehead position. Our findings are supported by control experiments, deuterium labeling and kinetic studies, cyclic voltammetry, Stern–Volmer experiments, as well as density functional theory (DFT) calculations.}, archive = {J_ANGEW}, author = {Zi-Yu Xu and Xin-Tao Gu and Yin Wei and Min Shi}, doi = {10.1002/anie.202506073}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-light-mediated intramolecular dearomatization of naphthalene and anthracene with bicyclo[1.1.0]butanes through energy transfer catalysis}, volume = {64}, year = {2025}, }
• (2025). High turnover frequency in the electrocatalytic reduction of nitrous oxide to dinitrogen at a binuclear copper complex of 3,5-diamino-1,2,4-triazole. ANGEW, 64(34), e202506067. (www)

  @article{ , abstract = {Nitrous oxide (N 2 O) is a potent greenhouse gas and an ozone-depleting substance. Electrocatalytic N 2 O reduction (e-N 2 ORR) is a promising approach to remove N 2 O from the air under ambient conditions. However, developing noble-metal-free e-N 2 ORR electrocatalysts with high Faradaic efficiency (FE) and turnover frequency (TOF) remains a challenge because of the weak binding of N 2 O and the high kinetic barrier for deoxygenation reaction. In this work, inspired by the multinuclear copper active site of nitrous oxide reductases, a binuclear copper complex of 3,5-diamino-1,2,4-triazole supported on carbon black of Ketjenblack (CuHdatrz/KB) was utilized for the e-N 2 ORR at pH 13 and 298 K. CuHdatrz/KB achieves a high FE of ≈ 100% at −0.3 V versus reversible hydrogen electrode for the e-N 2 ORR to N 2 and TOF up to ≈ 700 h −1 , which is one–two orders of magnitude higher than those of the previously reported molecular-based catalysts. In situ X-ray absorption spectroscopy confirmed that Cu(II) ions of CuHdatrz/KB are reduced to Cu(I) keeping the binuclear core, suggesting that the multinuclear copper active site is crucial to efficiently catalyze the e-N 2 ORR like the nitrous oxide reductase.}, archive = {J_ANGEW}, author = {Zhengwei Ma and Masaru Kato and Jenny Pirillo and Yuh Hijikata and Takeshi Watanabe and Yohei Uemura and Bang Lu and Satoru Takakusagi and Ken'ichi Kimijima and Hideo Notsu and Ichizo Yagi}, doi = {10.1002/anie.202506067}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202506067}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High turnover frequency in the electrocatalytic reduction of nitrous oxide to dinitrogen at a binuclear copper complex of 3,5-diamino-1,2,4-triazole}, volume = {64}, year = {2025}, }
• (2025). Dynamic active site evolution in lanthanum-based catalysts dictates ethane chlorination pathways. ANGEW, 64(34), e202505846. (www)

  @article{ , abstract = {Radical-mediated chlorination of ethane presents a low-carbon alternative for polyvinyl chloride (PVC) synthesis, yet selectivity toward 1,2-dichloroethane remains challenged by uncontrolled over-chlorination. Lanthanum oxychloride (LaOCl) has emerged as a promising catalyst, but its structural dynamics under Cl 2 -rich conditions and the origin of selectivity loss remain elusive. Here, we integrate advanced spectroscopic techniques with theoretical calculations to address this knowledge gap. Our findings unveil a sequential LaOCl → LaCl 3 transformation that dictates product distribution shifting from 1,2-dichloroethane to trichloroethane. Mechanistic insights reveal that surface hydroxyl groups, generated during catalyst chlorination, promote bidentate adsorption of 1,2-dichloroethane via hydrogen-bond networks, thereby activating C─Cl over-chlorination. Additionally, by employing Al 2 O 3 -supported LaCl 3 model catalysts, the size-dependent chlorophilicity of the LaCl 3 species is demonstrated. The bonding of interfacial oxygen with monolayer-dispersed LaCl 3 species generates empty 4f-states above the Fermi level, creating strong Lewis acid sites that stabilize Cl radicals and selectively convert chloroethane to 1,2-dichloroethane. In contrast, aggregated nanoparticles are inactive due to their inability to stabilize chlorine radical. Our findings establish important structure sensitivity in lanthanum-catalyzed chlorination and provide guiding principles for catalyst design, highlighting the importance of stabilizing metastable LaOCl x species and modulating surface hydroxyl chemistry to overcome selectivity limitations.}, archive = {J_ANGEW}, author = {Yuting Li and Haifeng Qi and Zihan Zhu and Xia Wu and Nicholas F. Dummer and Stuart H. Taylor and Lei Ma and Xiaofeng Yang and Qinggang Liu and Graham J. Hutchings and Yanqiang Huang}, doi = {10.1002/anie.202505846}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505846}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic active site evolution in lanthanum-based catalysts dictates ethane chlorination pathways}, volume = {64}, year = {2025}, }
• (2025). Highly crystalline and oriented thin films of fully conjugated 3D-covalent organic frameworks. ANGEW, 64(34), e202505799. (www)

  @article{ , abstract = {Fully conjugated 3D covalent organic frameworks (COFs) are a newly emerged class of materials that expands reticular chemistry to extended electron delocalization for optoelectronic applications. To overcome the limitations of sp 3 -connected 3D frameworks, the pseudo-tetrahedral motif cyclooctatetrathiophene (COTh) has gained attention for forming fully conjugated 3D COFs. We report on a novel COTh building block, featuring functional formyl groups directly attached to the core's conjugated thiophenes. The modulation synthesis approach with mono-functionalized inhibitors enables the formation of COTh-1P COF, which exhibited remarkable crystallinity and permanent porosity. By following this approach and by optimizing the synthesis conditions for the solvothermal growth of thin films, we fabricated the first preferentially oriented conjugated 3D COF films on various substrates without pre-functionalization. With these thin films, optical pump terahertz probe studies allowed us, for the first time with 3D-fully conjugated COFs, to provide insights into the excited state and charge-carrier dynamics of these unique organic frameworks. Low effective masses are discovered for valence and conduction bands by density functional theory simulations. The ability to create crystalline and oriented films of fully π-conjugated 3D COTh-based COFs on non-modified substrates is expected to open the way for integration of such frameworks into diverse optoelectronic applications.}, archive = {J_ANGEW}, author = {Ignacio Munoz-Alonso and Derya Bessinger and Stephan Reuter and Marcello Righetto and Laura Fuchs and Markus Döblinger and Dana D. Medina and Frank Ortmann and Laura M. Herz and Thomas Bein}, doi = {10.1002/anie.202505799}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505799}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly crystalline and oriented thin films of fully conjugated 3D-covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Visible light-driven deracemization of cyclic sulfonamides by quinuclidine and chiral arylthiol catalysis. ANGEW, 64(34), e202505719. (www)

  @article{ , abstract = {A photocatalytic system comprising an achiral tertiary amine and a chiral C 2 -symmetric arylthiol was developed for the deracemization of various cyclic sulfonamides. This protocol exhibited high yields, good to excellent enantioselectivity, and broad substrate scope. The resulting products can be readily transformed into diverse diarylmethylamines, presenting a viable alternative to metal-catalyzed asymmetric methods. The reaction pathway involving a relay of non-enantioselective hydrogen-atom abstraction (HAA) and enantioselective hydrogen-atom delivery (HAD).}, archive = {J_ANGEW}, author = {Lei Dai and Chaoren Shen and Jing Wang and Yanzhong Li and Kaiwu Dong}, doi = {10.1002/anie.202505719}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505719}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible light-driven deracemization of cyclic sulfonamides by quinuclidine and chiral arylthiol catalysis}, volume = {64}, year = {2025}, }
• (2025). Zwitterionic heavier pnictinidenes in redox catalysis. ANGEW, 64(34), e202505697. (www)

  @article{ , abstract = {Herein, we describe a new class of zwitterionic heavier pnictogen species with bis ( N -heterocyclic carbene)borate as ligands, enabling the isolation of stable Sb and Bi species in multiple oxidation states. Computational analysis of zwitterionic pnictinidenes revealed their cationic character at the metal centre while holding unique electronic properties that contribute to their nucleophilicity and stability. These systems participate in oxidative addition and reductive elimination processes, and display redox catalytic activity in hydrodefluorination reactions, marking a unique example of cationic pnictinidene catalysing a redox transformation and providing reactivity beyond the constraints of pincer ligands. Additionally, we report on a novel dehydrogenative thiolation of silanes. This work expands the scope of low-valent pnictogen chemistry, providing a novel platform for main group redox catalysis.}, archive = {J_ANGEW}, author = {Selwin Fernando and Yi Chen Chan and Sergio Fernandez and Enric Sabater and Graham Tizzard and Simon J. Coles and Diego M. Andrada and Oriol Planas}, doi = {10.1002/anie.202505697}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505697}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zwitterionic heavier pnictinidenes in redox catalysis}, volume = {64}, year = {2025}, }
• (2025). Branched-selective functionalization of 2-alkyl aziridines through ni-catalyzed dynamic kinetic activation. ANGEW, 64(34), e202505625. (www)

  @article{ , abstract = {Overriding the inherent substrate-controlled regioselectivity in aziridine activation holds significant potential. It could enable previously inaccessible disconnections from these readily available, strained heterocycles, facilitating the diverse synthesis of nitrogen-containing products. In this study, we present a Ni-catalyzed dynamic kinetic activation of 2-alkyl (and 2,2-dialkyl) aziridines, leading to unconventional branched-selective alkyl Heck-type coupling with styrenes and reductive defluorinative coupling with trifluoromethyl alkenes. In addition to enabling the functionalization of the N-adjacent sites of aziridines, this catalyst-controlled activation strategy triggers an unprecedented reaction framework for aziridines, namely, the remote desaturation via ring-opening. Notably, detailed mechanistic studies demonstrate the operation of a rare “self-terminated” chain-walking process, offering a flexible method for remote desaturation that generates alkenyl amines with varying chain lengths. Overall, this study provides a modular approach to access a wide range of alkenyl amine derivatives.}, archive = {J_ANGEW}, author = {Xin Chen and Chen Yang and Yun-Fei Bai and Lei Wang and Zhi-Qiao Li and Xianglu Peng and Gang-Wei Wang}, doi = {10.1002/anie.202505625}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505625}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Branched-selective functionalization of 2-alkyl aziridines through ni-catalyzed dynamic kinetic activation}, volume = {64}, year = {2025}, }
• (2025). Orchestrating penta-element interplay in gradient-porous carbons for advanced sodium-ion hybrid capacitors. ANGEW, 64(34), e202505469. (www)

  @article{ , abstract = {Sodium-ion hybrid capacitors (SIHCs) offer a cutting-edge synergy between battery-level energy density and supercapacitor-like power density, yet face critical challenges in balancing the kinetic and capacity mismatch between Faradaic anodes and capacitive cathodes. Herein, we present a penta-element doped gradient-porous carbon (PE-GPC) with a nanosphere architecture, engineered with high-entropy principles and a gradual pore density variation to enhance mass transport and charge storage. Operando spectroscopy and machine learning potentials unveil a concerted penta-element interplay: thiophene-like S configurations mediate dynamic redox processes, enabling pseudocapacitive Na⁺ and anion storage, while fluorine functionalities foster a self-rejuvenating NaF-rich solid electrolyte interphase (SEI), stabilizing long-term cycling. Meanwhile, the synergistic N/B/P triad engineers a hierarchical defect network that enhances electronic conductivity and fine-tunes ion adsorption energetics. This orchestrated interplay empowers the SIHC full cell with a high energy density of 196 Wh kg −1 , a formidable power density (10.4 kW kg −1 ), and an impressive 88.2% capacity retention after 9000 cycles. By establishing a high-entropy stabilization paradigm, this work paves the way for multi-ion storage architectures, offering a universal strategy to bridge the charge-transfer imbalance in advanced energy devices.}, archive = {J_ANGEW}, author = {Yangjie Liu and Yao Guo and Yu Zhang and Lihong Xu and Junxiang Chen and Xiang Hu and Zhenhai Wen}, doi = {10.1002/anie.202505469}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505469}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orchestrating penta-element interplay in gradient-porous carbons for advanced sodium-ion hybrid capacitors}, volume = {64}, year = {2025}, }
• (2025). Counterion-mediated luminophore dimerization. ANGEW, 64(34), e202505433. (www)

  @article{ , abstract = {Emissive organic salts have long been integral to the discovery of fluorescence phenomena and functional luminescent dyes. Typically, one component of the salt acts as the photoactive unit (luminophore) and its nonemissive counterion is selected to independently tune bulk physical properties, such as solubility. However, the impact of counterion choice on the aggregation and resulting emissive state of organic salts in solution has not been widely investigated. Here, we report that a single cationic luminophore gives rise to either monomer, dimer, excimer, or multichromatic emission under otherwise identical conditions by varying only its counterion. We employ N -methyl quininium ( MeQn + ) as a permanently charged cationic luminophore, which we pair with a series of monovalent anions. At low solution-state concentrations, all the salts give identical absorption and emission spectra that correlate with the MeQn + monomer. However, at higher concentrations, the emission, excitation, and absorption data differ, revealing the presence of monomer, dimer, excimer, or all three, depending on the structure of the anion. Understanding and modulating the formation of dimeric or other well-defined aggregated species by specific ion effects could be exploited in the design of molecular probes for biological systems or emissive thin-film dispersions for optoelectronic devices.}, archive = {J_ANGEW}, author = {Ash G. Carter and Promeet K. Saha and Antara Sikder and Juan A. Aguilar and Andrew P. Monkman and Alyssa-Jennifer Avestro and Marc K. Etherington and Paul R. McGonigal}, doi = {10.1002/anie.202505433}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505433}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Counterion-mediated luminophore dimerization}, volume = {64}, year = {2025}, }
• (2025). Controlled electrocatalytic glycerol upgrading to glyceraldehyde in near neutral media by cobalt oxide lattice activation. ANGEW, 64(34), e202505059. (www)

  @article{ , abstract = {Electrocatalytic upgrading of biomass-derived glycerol driven by renewable electricity offers a greatly attractive green way to produce value-added chemicals at much reduced global carbon footprint. However, achieving both the enhanced activity and selectivity for the most-valuable C3 product-glyceraldehyde (GAD) of glycerol oxidation reaction (GOR) in neutral media, though of great importance, is extremely challenging. In this work, we propose a Co 3 O 4 lattice activation mechanism by introducing single atom Ru (0.36 wt%) into the tetrahedral sites (Co Td ) of Co 3 O 4 lattice to significantly elevate the GOR activity and the GAD selectivity. The as-constructed Ru-Co 3 O 4 /NF only needs 1.16 V to achieve the current density of 10 mA cm −2 during GOR and maintains ∼60% GAD selectivity (∼90% for C3 products) over a broad potential window, which are the highest reported in near neutral media. This excellent performance has been demonstrated to originate from the introduction of Ru atoms, which activates the lattice active sites of Co 3 O 4 by promoting the rapid reconstruction of the catalyst to generate sufficient Co 3+ -(OH) ads electrophilic oxygen species, resulting in not only the accelerated GOR kinetics, also largely enhanced selectivity of GAD by the adsorption configuration regulation of glycerol primary alcohols (C α -OH) favoring the primary alcohol oxidation pathway.}, archive = {J_ANGEW}, author = {Wenshu Luo and Han Tian and Qin Li and Junqing Ma and Wen Sun and Libo Zhu and Han Wu and Fantao Kong and Xiaodong Zhuang and Xiangzhi Cui and Jianlin Shi}, doi = {10.1002/anie.202505059}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505059}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled electrocatalytic glycerol upgrading to glyceraldehyde in near neutral media by cobalt oxide lattice activation}, volume = {64}, year = {2025}, }
• (2025). Articular cartilage inspired ultra-strong and tough bio-based polyurethane nanofiber membranes. ANGEW, 64(34), e202505034. (www)

  @article{ , abstract = {Bio-based polyurethanes are promising sustainable elastomers whose polymeric network structure has a decisive impact on their properties. However, existing bio-based polyurethanes face challenges in simultaneously enhancing mechanical strength and toughness. Inspired by the multilevel heterogeneous structure of articular cartilage, we propose a bionic design strategy of rigid-flexible coupled supramolecular cross-linking networks to prepare bio-based polyurethane elastomers with enhanced strength and toughness. By incorporating the asymmetric coupling of rigid furan rings and flexible aliphatic side chains into the molecular chains, a dynamic hydrogen bond network with a gradient distribution of bond energy was constructed, achieving uniform microphase separation between the soft phase (amorphous) and the hard phase (crystalline). Nanofiber membranes were fabricated by rigid-flexible coupled polyurethane electrospinning, where the microphase-separated structure is further transformed into dynamic crystalline domains. Under external force, multilevel energy dissipation is achieved through the breaking and controllable recombination of hydrogen bonds within the crystalline domain. resulting in polyurethane nanofiber membranes with significantly enhanced mechanical strength and toughness (fracture strength: 31.37 MPa, fracture strain: 731.04%, toughness: 102.13 MJ m −3 ). This network design strategy expands the potential of bio-based elastomers in smart wearable textiles, flexible electronic devices, and biomedical applications, thereby advancing the development of sustainable high-performance polymers.}, archive = {J_ANGEW}, author = {Xueqin Li and Ningbo Cheng and Yanyan Lin and Bin Zhang and Yinzhi Yang and Chengran Qu and Xianfeng Wang and Jianyong Yu and Bin Ding}, doi = {10.1002/anie.202505034}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202505034}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Articular cartilage inspired ultra-strong and tough bio-based polyurethane nanofiber membranes}, volume = {64}, year = {2025}, }
• (2025). Sustainable closed-loop recycling of polyester waste using reconstructed defective-Metal–Organic frameworks. ANGEW, 64(34), e202504743. (www)

  @article{ , abstract = {Chemical recycling of polyester waste presents a promising strategy for achieving a sustainable circular economy. However, the development of efficient, low-cost recycling methods that minimize energy consumption and carbon emissions remains challenging. Here, we report an approach for depolymerization polyester waste to bis (hydroxyethyl)terephthalate (BHET) using a reconstructed metal–organic framework ( r -Zn–MOF74–NT) catalyst under mild conditions. The r -Zn–MOF74–NT exhibited a space-time yield of 1035.8 g BHET g cat −1 h −1 at 190 °C. Importantly, this is an order of magnitude higher than that reported for similar MOF-based catalysts. In situ spectroscopy combined with theoretical calculations revealed that the depolymerization pathway involves the activation of oxygen and ethylene glycol adsorbed on r -Zn–MOF74–NT, forming nucleophilic intermediates. These intermediates then facilitate the cleavage of the polyester C─O bond through nucleophilic attack, thereby gradually generating the BHET product. Sustainability evaluation results validated the circular economy feasibility of the recycling approach, with a minimum sales price (MSP) of 498 $/ton, much lower than the MSP of the traditional petroleum-based production route (1000 $/ton). The approach also achieved a 61% reduction in energy use and a 52% decrease in greenhouse gas emissions. This work provides a sustainable solution for managing polyester waste accumulation.}, archive = {J_ANGEW}, author = {Jingjing Cao and Wei Chen and Wei Jiang and Xiaodong Li and Ping Sun and Shaohai Fu and Quanxing Zhang}, doi = {10.1002/anie.202504743}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202504743}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sustainable closed-loop recycling of polyester waste using reconstructed defective-Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Electron-delocalized cu2+ activates spin channels in spinel oxides to selectively produce 1O2 for wastewater treatment. ANGEW, 64(34), e202504426. (www)

  @article{ , abstract = {Blocked electron transfer in the catalyst during advanced oxidation processes causes sluggish singlet oxygen ( 1 O 2 ) generation efficiency and sacrifices catalyst stability. In this work, we propose an electron-delocalization strategy that unlocks A Td 2+ ─O─B Oh 3+ electron-transfer pathways within spinel oxide (Cu 0.8 Fe 2.2 O 4 ), inducing the intermolecular electron transfer of peroxymonosulfate (PMS) for selective 1 O 2 generation. In situ characterizations and theoretical calculations confirm that the electron-delocalized Cu 2+ triggers a high spin-state of O in Fe Td 2+ ─O─Fe Oh 3+ , thus creating a spin channel for the spontaneous intermolecular electron transfer of PMS from the Fe Oh 3+ adsorption site to the Fe Td 2+ adsorption site through Fe Td 2+ ─O─Fe Oh 3+ . This process allows for the simultaneous oxidation and reduction of PMS, thereby reducing the energy barriers for the formation of SO 4 •− and SO 5 •− radicals. Subsequently, the interfacial SO 4 •− rapidly oxidizes SO 5 •− into 1 O 2 , enhancing 1 O 2 generation efficiency without sacrificing catalyst stability. The selectivity of 1 O 2 in the Cu 0.8 Fe 2.2 O 4 /PMS system reaches 98.4%. Multiple pollutants are removed in the Cu 0.8 Fe 2.2 O 4 /PMS system without interference from coexisting substances. The scale-up experiment realizes 100% contaminant removal during the continuous operation process (48 h). This work exhibits a novel strategy for selective 1 O 2 generation to achieve the goal of practical applications.}, archive = {J_ANGEW}, author = {Le-Yang Hao and Zi-Jun Tang and Chu-Yi Cai and Yu-Chen Zhao and Lei Tian and Nan Li and Zhao-Qing Liu}, doi = {10.1002/anie.202504426}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202504426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron-delocalized cu2+ activates spin channels in spinel oxides to selectively produce 1O2 for wastewater treatment}, volume = {64}, year = {2025}, }
• (2025). Regioselective C─H functionalization by the combination of enzymatic and chemocatalytic reactions in water. ANGEW, 64(34), e202504378. (www)

  @article{ , abstract = {The combination of bio- and chemo-catalytic processes has tremendous potential for the sustainable production of important synthetic building blocks. Such approaches capitalize on the often-high selectivity of enzymes and the broad arsenal of synthetic transformations to access highly functionalized molecules from simple precursors. However, the strict requirement of enzymes for an aqueous reaction environment, often combined with their lack of stability under harsh reaction conditions, makes the development of efficient chemo-enzymatic cascade reactions challenging. Within this work, we developed a chemo-enzymatic platform that combines regioselective enzymatic H alogenation, chemo-catalytic H eck coupling, and an enzyme-catalyzed H ydrolysis reaction (H 3 Catalytic Platform = H 3 CP) in a single reaction vessel. H 3 CP uses water as a reaction solvent to facilitate the enzymatic transformations, with the cross-coupling reaction taking place in dynamic and protective super-molecular reaction vessels composed of the commercially available TPGS-705-M. Our work utilizes various halogenating enzymes (FDHs and VHPOs), selectively functionalizing diverse substrates, thus enabling subsequent metal-catalyzed cross-coupling followed by enzymatic hydrolysis. H 3 CP gives access to a broad range of valuable acrylic acid building blocks with diverse functionalization at the aromatic portion.}, archive = {J_ANGEW}, author = {Ran Zhu and Xuhua Mo and Tanja Gulder and Tobias A. M. Gulder}, doi = {10.1002/anie.202504378}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202504378}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioselective C─H functionalization by the combination of enzymatic and chemocatalytic reactions in water}, volume = {64}, year = {2025}, }
• (2025). Precise molecular engineering of heptamethine cyanine-based near-infrared type-I photosensitizers for pro-death autophagy and hypoxia-tolerant antitumor treatment. ANGEW, 64(34), e202504227. (www)

  @article{ , abstract = {Heptamethine cyanine ( Cy7 ) dyes have excellent near-infrared (NIR) fluorescence imaging capability but competitively inhibit the photodynamic therapy (PDT) effect, especially in hypoxic solid tumors. In this study, a series of aryl-ketone-modified Cy7 derivatives ( ACy ) were constructed to transform Cy7 into a type-I photosensitizer capable of both hydrogen (H)-abstraction and electron transfer for the first time. The introduction of an aryl-ketone group at the C3 position of Cy7 imparted it with H-abstraction capability and enhanced its intersystem crossing efficiency. Moreover, an increase in the steric hindrance of the aryl-ketone group promoted the efficiency of the H-abstraction reaction and electron transfer process. Optimized molecules, 3ACy-3ipr , not only exhibited bright fluorescence but also generated hydroxyl and alkyl radicals upon NIR light irradiation. These radicals induced mitochondrial autophagy in hypoxic tumor cells, eventually leading to necrosis and ferroptosis. Tumor targeting peptide modified liposomes were used to construct nanocarriers to improve the biocompatibility and tumor retention of 3ACy-3ipr , which fluoresces at the tumor site and significantly inhibited the growth of solid tumors via PDT. This study provides an excellent platform for the precise development and clinical utilization of NIR theranostic agents.}, archive = {J_ANGEW}, author = {Fuping Han and Mengya Guo and Xiao Zhou and Zhenyu Zhang and Hongyi Zhang and Lihan Cai and Xin Li and Tiancong Shi and Saran Long and Wen Sun and Jianjun Du and Jiangli Fan and Xiaojun Peng}, doi = {10.1002/anie.202504227}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202504227}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise molecular engineering of heptamethine cyanine-based near-infrared type-I photosensitizers for pro-death autophagy and hypoxia-tolerant antitumor treatment}, volume = {64}, year = {2025}, }
• (2025). Building a bridge between ambient MS and LC-MS by non-exhaustive microdesorption. ANGEW, 64(34), e202504080. (www)

  @article{ , abstract = {Ambient mass spectrometry (AMS) offers rapid screening but faces challenges in analyzing complex samples due to high matrix effects. The absence of a separation step can also lead to false positives due to the isomers or isobars. In this study, a sequential analysis strategy which combines ambient MS and LC-MS based on the non-exhaustive microdesorption in solid-phase microextraction (SPME) was developed for the first time. By combining coated blade spray (CBS)-MS with LC-MS, in the first step, a few microliters of solvent were used for non-exhaustive desorption with high enrichment factor for rapid screening by CBS-MS. For the suspicious samples, the remaining analytes on the SPME coating undergo exhaustive desorption, then followed by LC-MS confirmation. The matrix-compatible coating used in the SPME device significantly reduces matrix effects while enhancing sensitivity through analyte enrichment. This method is environmentally friendly, utilizing only a few microliters of organic solvents for screening. The approach was rigorously validated, both theoretically and experimentally, and successfully applied to anti-doping testing, enabling detection of 53 prohibited substances in urine samples by integrating CBS-MS with LC-MS.}, archive = {J_ANGEW}, author = {Wei Zhou and Janusz Pawliszyn}, doi = {10.1002/anie.202504080}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202504080}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Building a bridge between ambient MS and LC-MS by non-exhaustive microdesorption}, volume = {64}, year = {2025}, }
• (2025). High-capacity and long-life cathode constructed solely by carbon dots for aqueous zinc-ion batteries. ANGEW, 64(34), e202503655. (www)

  @article{ , abstract = {Carbon dots (CDs) have been explored widely in the electrochemistry field, owing to their unique structures and rich properties. However, in the reported devices, such as batteries and supercapacitors, CDs are always used as additives to modify the electrodes or regulate the electrolytes because they have been regarded as inert and low-capacity materials all along. Here, for the first time, o -phenylenediamine derived CDs are selected as the only protagonist to construct cathode materials for aqueous zinc-ion batteries (ZIBs). Such CDs (p-CDs) have a special π-conjugated phenazine-based structure, with carbon cores for electrical conductivity and active sites for embedding Zn 2+ and H + . The p-CDs solely constructed cathode material delivers a superior capacity of 290 mAh g −1 at 0.1 A g −1 and a decent capacity of 103 mAh g −1 at an ultra-high current density of 10 A g −1 , as well as an ultrahigh ion diffusion coefficient of 10 −8 ∼ 10 −7 cm 2 s −1 . The p-CDs assembled ZIBs exhibit a stable long-term cycling, retaining 87.4% of the original capacity after 10 000 cycles. Various characterizations and theoretical calculations prove that the electron-deficient N as the active sites on p-CDs can embed/release Zn 2+ and H + reversibly.}, archive = {J_ANGEW}, author = {Tian-Bing Song and Qian-Li Ma and Bao-Juan Wang and Xi-Rong Zhang and Yong-Gang Wang and Huan-Ming Xiong}, doi = {10.1002/anie.202503655}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202503655}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-capacity and long-life cathode constructed solely by carbon dots for aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Selective phosphorylation of phenols and benzenediols by the kinase PsiK and variants thereof. ANGEW, 64(34), e202503538. (www)

  @article{ , abstract = {Phosphorylation plays important roles in biology by modulating the structure, reactivity, and biological function of a broad range of molecules. Biocatalytic phosphorylation has attracted attention from synthetic chemists due to its selectivity and mild reaction conditions using ATP as a phosphate donor. Given the potential synthetic utility of kinases with activity on small molecule substrates, we explored the activity of PsiK, the enzyme responsible for selective 4- O -phosphorylation of 4-hydroxytryptamine or psilocin in psylocybin biosynthesis by Psilocybe cubensis . We find that PsiK has good activity on a range of substituted phenols and benzenediols beyond its native substrate, enabling preparative phosphorylation of different substrates, and substantially expands the substrate scope of biocatalytic phosphorylation. We also show that active site mutations can further expand substrate scope and improve site-selectivity. This engineering effort was greatly expedited using DESI-MS screening, which enabled analysis of 2688 reactions in only 40 min. Finally, gram-scale phosphorylation of a representative substrate was achieved with a turnover number over 10 000. Together, these results highlight the biocatalytic utility of PsiK and derivatives thereof for selective phosphorylation of phenols and benzenediols under mild conditions.}, archive = {J_ANGEW}, author = {Ahram Kim and Nicolás M. Morato and Prabir Saha and Pascal N. Eyimegwu and Aqeel A. Niyaz and Rui Huang and R. Graham Cooks and Ryan M. Phelan and Jared C. Lewis}, doi = {10.1002/anie.202503538}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202503538}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective phosphorylation of phenols and benzenediols by the kinase PsiK and variants thereof}, volume = {64}, year = {2025}, }
• (2025). Amide chemistry enables redox locking of cyclic disulfides for polypeptide assembly. ANGEW, 64(34), e202502880. (www)

  @article{ , abstract = {A practical strategy in synthetic organic chemistry for shutting down temporarily the nucleophilicity of thiols is to exploit their redox properties by converting them into disulfides. The stability of such a thiol protection in reductive medium can be sensitive to microenvironmental changes, including chemical modifications occurring nearby. Although difficult to achieve, large shifts in disulfide stability might provide a practical mean for bringing selectivity in a reacting system comprising multiple thiol functionalities. Here we report that the stability of a cyclic disulfide increases dramatically upon acylation of an amino group placed in the vicinity of the S─S bond. The gain in stability is so pronounced that the amide bond formation acts as a redox lock. We describe the application of such a redox switch to the chemoselective assembly of polypeptides by thiol-based peptide ligation chemistries.}, archive = {J_ANGEW}, author = {Vincent Diemer and Eliott Roy and Benoît Snella and Frédéric Capet and Oleg Melnyk}, doi = {10.1002/anie.202502880}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202502880}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amide chemistry enables redox locking of cyclic disulfides for polypeptide assembly}, volume = {64}, year = {2025}, }
• (2025). Quantitative tracking of apoptotic caspase-3 in vivo for early evaluation of radiation therapy efficacy. ANGEW, 64(34), e202502811. (www)

  @article{ , abstract = {Traditional responsive fluorescent probes are predominantly restricted to qualitative biomarker detection, incapable of delivering real-time quantitative analysis or spatial mapping of protease activity in vivo, which is essential for elucidating disease progression. To overcome this, a ratiometric second near-infrared region (NIR-II) fluorescent (FL) probe (DCNP@IR-806) was developed by conjugating caspase-3-specific peptide substrates and sensitizer molecules (IR-806) to lanthanide-doped down-conversion nanoparticles (DCNP). DCNP@IR-806 achieves single-channel emission at 1550 nm under dual excitation, facilitating self-calibrated quantification and real-time monitoring of activated caspase-3 in vivo. Radiotherapy induces tumor cell apoptosis, thereby activating caspase-3, which subsequently triggers a ratiometric NIR-II FL signal change of DCNP@IR-806. The ratiometric signal demonstrates a linear correlation with caspase-3 concentration, achieving a detection limit of 9.96 U mL −1 . Then, an early efficacy assessment system capable of predicting radiotherapy outcomes within 12 h post-treatment was constructed, markedly expediting evaluation compared to traditional methods that require weeks. This rapid, precise, and user-friendly assessment facilitates timely optimization of therapeutic regimens to enhance efficacy while minimizing side effects. This platform represents a significant advancement in precision oncology by transitioning from qualitative imaging to in situ quantitative biomarker tracking.}, archive = {J_ANGEW}, author = {Ying Wu and Qian Wang and Kang Zhu and Liting Zheng and Qingqing Li and Wei Huang and Yang Du and Lanlan Chen and Jibin Song and Huanghao Yang}, doi = {10.1002/anie.202502811}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202502811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantitative tracking of apoptotic caspase-3 in vivo for early evaluation of radiation therapy efficacy}, volume = {64}, year = {2025}, }
• (2025). Linking metallacycle transfer with ring-opening metathesis to generate polyacetylenes of unprecedented structure. ANGEW, 64(34), e202502801. (www)

  @article{ , abstract = {A hafnium-based bicyclic precursor ( COT-2B-Hf ) has been prepared that enables tandem Hf/E metallacycle transfer (E = main group element) and the ring-opening metathesis polymerization (ROMP) of cyclooctatetraene (COT) units to generate a new family of structurally unique polyacetylenes. Highlights from this work include a tellurophene-grafted polyacetylene, poly-COT-2B-Te , and a polyacetylene with unsaturated vinyl side chains, poly-COT-2B-vinyl . The resulting polymers can be processed into films that yield optical band gaps as low as 1.6 eV, representing promising new architectures for the optoelectronics community.}, archive = {J_ANGEW}, author = {Abhishek V. Muralidharan and Michael J. Ferguson and Eric Rivard}, doi = {10.1002/anie.202502801}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202502801}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Linking metallacycle transfer with ring-opening metathesis to generate polyacetylenes of unprecedented structure}, volume = {64}, year = {2025}, }
• (2025). Regiodivergent photocatalytic annulation for the synthesis of gem-difluorinated cyclic hydrocarbons. ANGEW, 64(34), e202502450. (www)

  @article{ , abstract = {Regiodivergent synthesis is a powerful strategy for expanding chemical space. Given the significance of fluorine-containing molecules in pharmaceutical sciences, a regiodivergent [3+2] cycloaddition of gem -difluorocyclopropyl urea to olefins and [1.1.0]-bicyclobutanes was developed by employing cationic iridium complexes as photocatalysts under visible-light irradiation. By properly selecting a counteranion of the photocatalyst and tuning the reaction conditions, each regioisomeric cyclic hydrocarbon with a defined gem -difluoromethylene disposition was directly assembled with high selectivity. Mechanistic elucidation revealed the critical relevance of the basicity of the photocatalyst counteranion to the regiochemical outcome. The reaction diverges depending on the intervention of deprotonation of the initially generated urea radical cation by the pairing anion to form the corresponding neutral radical; this not only governs the regioselective ring opening of the cyclopropane moiety but also modulates the relative reactivity of the two resulting terminal carbon radicals, thereby dictating the dominant pathway.}, archive = {J_ANGEW}, author = {Tobias E. Schirmer and Julian C. G. Kürschner and Yuki Uchida and Yuya Taura and Pablo Gabriel and Line Næsborg and Daisuke Yokogawa and Yoshitaka Aramaki and Takashi Ooi}, doi = {10.1002/anie.202502450}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202502450}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regiodivergent photocatalytic annulation for the synthesis of gem-difluorinated cyclic hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). Plasmonic nanoparticle monolayer-decorated nanopipette enabling in situ monitoring of single-cell redox metabolism. ANGEW, 64(34), e202502129. (www)

  @article{ , abstract = {The in-depth study of how single cells respond to redox perturbations is pivotal for predicting cell fate decisions. Surface-enhanced Raman spectroscopy (SERS)-active nanopipettes hold promise for single-cell analysis, yet challenges remain in achieving both signal sensitivity and reproducibility. Here, a plasmonic nanoparticle monolayer-decorated nanopipette has been developed, which serves as a biomimetic endoscope to monitor single-cell redox metabolism. This is accomplished by the conformal transferring of gold nanoparticle monolayer onto the nanopipette followed by the functionalization of redox-responsive probes. The strong near-field coupling within monolayer forms uniform hotspots, enabling highly sensitive and reproducible tracking of SERS signals changes triggered by redox species. Modulated by the nanopipette technology, the endoscope allows for in situ monitoring of global redox states with low invasiveness and high spatial resolution. Further, study of ferroptosis events via simultaneous optical and electrical recording elucidates the correlation between redox imbalance and membrane damage during various ferroptosis-inducers stimulation, which has not been observed at the single-cell level. This work provides profound insights into the cellular redox dynamics, contributing to a deeper understanding of related physiopathological pathways.}, archive = {J_ANGEW}, author = {Lei Jiang and Mengqi Zhao and Hanbin Xu and Xin Ding and Qiaoyi Lu and Jiwei Liu and Liping Song and Lijuan Gong and Dawei Li and Youju Huang}, doi = {10.1002/anie.202502129}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202502129}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plasmonic nanoparticle monolayer-decorated nanopipette enabling in situ monitoring of single-cell redox metabolism}, volume = {64}, year = {2025}, }
• (2025). Exploring mesoionic imine-carbodiimide (MII-CDI) adducts: 1,3 H-shift, N(I) compounds and guanidinate-type ligands. ANGEW, 64(34), e202502097. (www)

  @article{ , abstract = {In this study, we report our recent findings on the synthesis and reactivity of a novel 1,2,3-triazolin-5-imine-type mesoionic imine-carbodiimide ( MII-CDI ) adduct. Unlike reported NHC-CDI adducts, formed by the reactions of N -heterocyclic carbene ( NHC ) with CDI , these zwitterionic compounds undergo a spontaneous 1,3-hydrogen shift (1,3-H shift), resulting in guanidine-type compounds. The mechanism of this 1,3-H shift has been investigated through quantum chemical calculations. The MII-CDI adduct serves as a valuable synthon for the synthesis of mesoionic carbene-acyclic diamino carbene (MIC-ADC)-based nitreone ( N(I) ) compounds. We have conducted a detailed investigation into the electronic properties, chemical reactivity, and electrochemical behavior of these nitreone ( N(I) ) compounds. Additionally, the potential of these MII-CDI adducts as guanidinate ligands is explored. Our investigations here display the distinct reactivities of MII in contrast to their N -heterocyclic imine ( NHI ) congeners.}, archive = {J_ANGEW}, author = {Alok Mahata and Richard Rudolf and Robert R. M. Walter and Nicolás. I. Neuman and Biprajit Sarkar}, doi = {10.1002/anie.202502097}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202502097}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploring mesoionic imine-carbodiimide (MII-CDI) adducts: 1,3 H-shift, N(I) compounds and guanidinate-type ligands}, volume = {64}, year = {2025}, }
• (2025). First chiral catalan solid based on molybdenum halide with efficient circularly polarized luminescence in the deep-red region. ANGEW, 64(34), e202502029. (www)

  @article{ , abstract = {The design of novel chiral metal halides with exceptional chiroptical properties has attracted significant research attention due to their potential applications in chiral optoelectronics and spintronics. However, developing the deep-red circularly polarized luminescence (CPL) emitters is still challenging. In this work, we presented the first chiral molybdenum halide clusters by incorporating chiral methylbenzylammonium ( R / S -MBA) for the design of ( R -MBA) 2 Mo 6 Cl 14 and ( S -MBA) 2 Mo 6 Cl 14 tetrakis hexahedra, which adopt the unique Catalan solid structure. These chiral tetrakis hexahedra exhibit 24 unique 3 c -2 e Mo─Mo─Cl bonds, which are scarcely reported. Notably, these ( R -MBA) 2 Mo 6 Cl 14 and ( S -MBA) 2 Mo 6 Cl 14 tetrakis hexahedra demonstrated pronounced circularly polarized luminescence in the deep-red region, accompanied by an extended emission lifetime of 114.14 µs at room temperature. Additionally, these chiral molybdenum halide tetrakis hexahedra are optically stable for 3 months. The four-state spin sublevel model was employed to investigate the emission mechanism and found that the temperature-dependent exciton dynamics lead to the dual-band emission of the designed chiral tetrakis hexahedra. Our study expands the family of lead-free chiral metal halides and develops a novel strategy to design a high-performance deep-red CPL emitter.}, archive = {J_ANGEW}, author = {Sehrish Gull and Wenkai Zhao and Zhaoyu Wang and Yunxin Zhang and Haolin Lu and Xinyi Niu and Tianjiao Qiao and Hebin Wang and Tianyin Shao and Wenting Liu and Bing Sun and Hao-Li Zhang and Yongsheng Chen and Guankui Long}, doi = {10.1002/anie.202502029}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202502029}, shortjournal = {Angew. Chem. Int. Edit.}, title = {First chiral catalan solid based on molybdenum halide with efficient circularly polarized luminescence in the deep-red region}, volume = {64}, year = {2025}, }
• (2025). Multiactivity of nanozyme liposome regulates the homeostasis of biochemical microenvironment. ANGEW, 64(34), e202501918. (www)

  @article{ , abstract = {In living systems, cascade reactions involving multiple enzymes, critical for regulating the biochemical microenvironment's homeostasis, are essential to transplantation remodeling. However, for ready-to-use purposes, designing and constructing therapeutic liposomes that replicate natural cell functions during the initial transplantation phase remains a significant challenge in synthetic biology for tissue engineering. Herein, we developed a biomimetic liposome with multienzymatic nanozyme activity to regulate proinflammatory factors induced by exogenous implants. The liposomes were fabricated through the self-assembly of artificial membranes on CeO 2 nanoparticles (NPs). These membranes, featuring a negatively charged surface analogous to endothelial cell (EC) membranes, effectively attenuate blood component adhesion and aggregation. The CeO 2 nanozyme not only hydrolyzes adenosine triphosphate/adenosine diphosphate (ATP/ADP) to adenosine monophosphate (AMP), reducing subsequent platelet aggregation, but also regulates biochemical microenvironment homeostasis, thereby promoting tissue regeneration. This work advances the development of cell-like entities capable of modulating signaling communication between living and abiotic interfaces.}, archive = {J_ANGEW}, author = {Yuanhong Min and Yinhua Qin and Haiyan Yin and Ting Gao and Xiaowen Guan and Xiaohang Qu and Yong Liu and Ju Tan and Jianhua Xu and Yonghong Fan and Chuhong Zhu and Youqian Xu}, doi = {10.1002/anie.202501918}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202501918}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiactivity of nanozyme liposome regulates the homeostasis of biochemical microenvironment}, volume = {64}, year = {2025}, }
• (2025). AM-DMF-ddRPA: An all-in-one digital microfluidic platform for rapid and automatic digital nucleic acid analysis. ANGEW, 64(34), e202501913. (www)

  @article{ , abstract = {Accurate nucleic acid quantification analysis (NQA) is crucial for disease treatment and prevention. However, existing digital NQA methods often lack sufficient automation and speed. In this study, we introduce a novel rapid and automated active-matrix digital microfluidics-based droplet digital recombinase polymerase amplification method (AM-DMF-ddRPA). This method can quantify influenza A and B viruses (IAV and IBV) within a mere 60 min, covering the entire workflow from nucleic acid extraction to digital amplification, fluorescence detection, and statistical analysis. We fabricated an AM-DMF chip equipped with high-throughput electrodes and optimized its control logic. Leveraging an artificial intelligence droplet navigation algorithm, we successfully achieved motion and mixing operations of high-throughput droplets (4608 droplets, each with a volume of 0.9 nL). A dual-target RPA system was designed to detect IAV and IBV, and its detection performance was fine-tuned. Experiments conducted with clinical samples revealed that this method exhibits ultra-high sensitivity for single-molecule detection, with a detection limit of 1.69 copies per reaction, and it achieved 100% concordance with qPCR results. This groundbreaking quantification technology holds tremendous promise for advancing disease diagnosis, treatment, and fundamental research.}, archive = {J_ANGEW}, author = {Jiajian Ji and Xinpei Pang and Chunyu Chang and Dongping Wang and Siyi Hu and Zhixin Fang and Chao Yu and Qian Mei and Hanbin Ma}, doi = {10.1002/anie.202501913}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202501913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {AM-DMF-ddRPA: An all-in-one digital microfluidic platform for rapid and automatic digital nucleic acid analysis}, volume = {64}, year = {2025}, }
• (2025). Encapsulating ionophores in zeolite imidazolate framework-8 for long-term monitoring of ion fluctuations in living rat brain. ANGEW, 64(34), e202501901. (www)

  @article{ , abstract = {Various ions in the brain (e.g., H + , K + , and Ca 2+ ) play essential roles in neural information transmission and physiopathological processes. Real-time monitoring of these ions will provide critical information for understanding neural functions and diagnosing diseases. However, long-term monitoring the dynamics of ions with microelectrodes remains a challenge due to the limited availability of sensing strategies capable of in vivo measurements with high stability in the mechanically soft and chemically complex brain of freely moving rats. Here, we develop a flexible and stable ion-selective microsensor for long-term monitoring of ions in rat brain, in which zeolite imidazolate framework-8 (ZIF-8) nanoparticles incorporated with ionophores are used for selective ion recognition and flexible polyvinyl alcohol (PVA) fibers sputtered with gold nanoparticles (AuNP) is used as the soft electrode substrate. The flexible microsensors allow long-term in vivo ion sensing with good stability in the brain of behaving rat, avoiding progressively deteriorating response of traditional polymer-based rigid ion selective microsensor caused by its instability interface and mechanical mismatch to soft brain tissue.}, archive = {J_ANGEW}, author = {Rantong Liu and Shuai Zhang and Guoyuan Ren and Peng Jin and Hui Zeng and Yongyue Yin and Tianyuan Wang and Meining Zhang and Lanqun Mao}, doi = {10.1002/anie.202501901}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202501901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Encapsulating ionophores in zeolite imidazolate framework-8 for long-term monitoring of ion fluctuations in living rat brain}, volume = {64}, year = {2025}, }
• (2025). Engineering graphene nanoribbons via periodically embedding oxygen atoms. ANGEW, 64(34), e202500490. (www)

  @article{ , abstract = {Heteroatom doping is an important method for engineering graphene nanoribbons (GNRs) because of its ability to modify electronic properties by introducing extra electrons or vacancies. However, precisely integrating oxygen atoms into the lattice of GNRs is unexplored, and the resulting electronic properties remain elusive. Here, we achieve the precise embedding of oxygen atoms into the lattice of GNRs via in situ formation of pyrans, synthesizing two types of oxygen-doped GNRs (O-doped chevron-GNR and O-doped chiral (2,1)-GNR). Using scanning tunneling microscopy, noncontact atomic force microscopy, and density functional theory calculations, the atomic structures and electronic properties of O-doped GNRs are determined, demonstrating that both GNRs are direct bandgap semiconductors with different sensitivities to oxygen dopants. Oxygen dopants have a minor impact on the bandgap of chevron-GNR but a significant effect on the bandgap of chiral (2,1)-GNR, which is attributed to the difference in density of states near the Fermi level between substituted intrinsic carbon atoms and their pristine counterparts. Compared with the pristine chiral (2,1)-GNR, the band structure of O-doped chiral (2,1)-GNR exhibits unexpected band edges transition, which is ascribed to sp 2 -hybridized oxygen atoms which introduces additional electrons to the conduction band of chiral (2,1)-GNR, leading to the upward shift of Fermi surface.}, archive = {J_ANGEW}, author = {Yan Zhao and Li-Xia Kang and Yi-Jun Wang and Yi Wu and Guang-Yan Xing and Shi-Wen Li and Jinliang Pan and Nie-Wei Wang and Yin-Ti Ren and Ying Wang and Ya-Cheng Zhu and Xing-Qiang Shi and Mengxi Liu and Xiaohui Qiu and Pei-Nian Liu and Deng-Yuan Li}, doi = {10.1002/anie.202500490}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {34}, pages = {e202500490}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering graphene nanoribbons via periodically embedding oxygen atoms}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Mechanoactivated celite as a catalyst for C‒H bond perfluoroalkylation and other radical reactions. ANGEW, 64(33), e202583302. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583302}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202583302}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Mechanoactivated celite as a catalyst for C‒H bond perfluoroalkylation and other radical reactions}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Deciphering and predicting thermal and pH stabilities of triplex DNA under multifactorial conditions. ANGEW, 64(33), e202583301. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583301}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202583301}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Deciphering and predicting thermal and pH stabilities of triplex DNA under multifactorial conditions}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Step test for rapid screening of material and process parameters for resin development in DLP 3D printing. ANGEW, 64(33), e202515321. (www)

  @article{ , archive = {J_ANGEW}, author = {Michelle Vigogne and Cosima Aeschbach and Ricardo Bernhardt and Anika Kaufmann and Julian Thiele}, doi = {10.1002/anie.202515321}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202515321}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Step test for rapid screening of material and process parameters for resin development in DLP 3D printing}, volume = {64}, year = {2025}, }
• (2025). An immobilized rh-based solid molecular catalyst for the reductive hydroformylation of 1-octene. ANGEW, 64(33), e202514871. (www)

  @article{ , archive = {J_ANGEW}, author = {Keanu V. A. Birkelbach and Jeroen T. Vossen and Thorsten Rösler and Isabella Kappel and Ansgar Meise and Marc Heggen and Andreas J. Vorholt and Regina Palkovits}, doi = {10.1002/anie.202514871}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202514871}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An immobilized rh-based solid molecular catalyst for the reductive hydroformylation of 1-octene}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: A bidirectional ion kinetic regulator suppressing lithium dendrites in advanced lithium-sulfur batteries. ANGEW, 64(33), e202514571. (www)

  @article{ , archive = {J_ANGEW}, author = {Jun Jiang and Yanwen Ding and Shujun Liu and Zhijie Qi and Tong Guo and Zhihua Wang and Jingwen Sun and He Zhu and Xiaoping Ouyang and Xin Wang and Junwu Zhu and Yongsheng Fu}, doi = {10.1002/anie.202514571}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202514571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: A bidirectional ion kinetic regulator suppressing lithium dendrites in advanced lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Correction to “Dynamic phosphorescence behavior of carbene-metal-amide complexes from the perspective of excited state modulation”. ANGEW, 64(33), e202514329. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202514329}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202514329}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Dynamic phosphorescence behavior of carbene-metal-amide complexes from the perspective of excited state modulation”}, volume = {64}, year = {2025}, }
• (2025). Fredrik schaufelberger. ANGEW, 64(33), e202514011. (www)

  @article{ , archive = {J_ANGEW}, author = {Fredrik Schaufelberger}, doi = {10.1002/anie.202514011}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202514011}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fredrik schaufelberger}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Fortification of FeS clusters reshapes anaerobic CO dehydrogenase into an air-viable enzyme through multilayered sealing of o2 tunnels. ANGEW, 64(33), e202513513. (www)

  @article{ , archive = {J_ANGEW}, author = {Suk Min Kim and So Yeon Kong and Jingu Kang and Jeong Seok Ji and Sung Heuck Kang and Hye-Jin Yoon and Hyunwoo Kim and Jungki Ryu and Hyung Ho Lee and Yong Hwan Kim}, doi = {10.1002/anie.202513513}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202513513}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Fortification of FeS clusters reshapes anaerobic CO dehydrogenase into an air-viable enzyme through multilayered sealing of o2 tunnels}, volume = {64}, year = {2025}, }
• (2025). Transform the world through chemistry. ANGEW, 64(33), e202512699. (www)

  @article{ , archive = {J_ANGEW}, author = {Paul T. Anastas and Walter Leitner}, doi = {10.1002/anie.202512699}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202512699}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transform the world through chemistry}, volume = {64}, year = {2025}, }
• (2025). Tae su choi. ANGEW, 64(33), e202511901. (www)

  @article{ , archive = {J_ANGEW}, author = {Tae Su Choi}, doi = {10.1002/anie.202511901}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202511901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tae su choi}, volume = {64}, year = {2025}, }
• (2025). Unlocking the potential of mn-based catalyst for durable two-electron oxygen reduction in acid at high current densities. ANGEW, 64(33), e202511844. (www)

  @article{ , abstract = {Electrochemical synthesis of H 2 O 2 by two-electron oxygen reduction (2e − ORR) often shows limited stability at high current densities in acidic media. Mn-based catalysts have been demonstrated highly stable for four-electron ORR thanks to their intrinsically low rate constant for Fenton-like reactions. However, their activity toward acidic 2e − ORR remains low because of too strong adsorption to *OOH. Here, we report a diatomic Mn catalyst with high-spin Mn II centers to enable high onset potential (0.69 V), high selectivity (>90%), and outstanding stability (240 h under 300 mA cm −2 ) toward H 2 O 2 electrosynthesis in acid. Theoretical calculations and in situ spectroscopies reveal that the diatomic Mn sites have downshifted d -band center and thus weakened adsorption strength for *OOH. Moreover, the inertia of the Mn II sites toward the troublesome Fenton-like reactions leads to the long-term stability at high current densities. We further demonstrate the functionalization of waste polyethylene (PE) using the high-concentration H 2 O 2 as produced, which provides a sustainable route toward on-site upcycling of plastic waste.}, archive = {J_ANGEW}, author = {Helai Huang and Mingze Sun and Kai Chen and Yizhen Che and Xin Tang and Zhengwen Li and Kaiqi Nie and Shuairen Qian and Jinjie Fang and Haiyong Wang and Yanfen Wu and Qikun Hu and Yuqi Wang and Xiaohang Sun and Junliang He and Yu-Xiao Zhang and Zhongbin Zhuang and Liang Zhang and Zhiqiang Niu}, doi = {10.1002/anie.202511844}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202511844}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking the potential of mn-based catalyst for durable two-electron oxygen reduction in acid at high current densities}, volume = {64}, year = {2025}, }
• (2025). Collision-induced fragmentation of oligosaccharides: Mechanistic insights for mass spectrometry-based glycomics. ANGEW, 64(33), e202511591. (www)

  @article{ , abstract = {Structural alterations in oligosaccharides are often associated with disease, positioning clinical glycomics as an emerging tool for diagnostics. This is most commonly achieved using a controlled collision-induced dissociation (CID) of larger oligosaccharides into fragments and measuring their mass in a mass spectrometer. Due to the complexity of oligosaccharides, and particularly their unusual fragmentation mechanisms, the underlying processes are poorly understood. Deciphering glycan fragmentation and making it understandable is highly desirable and would transform the field of glycomics from an expert technique into a widely applicable tool available to non-specialists. Here, we review the current knowledge of glycan fragmentation mechanisms in CID, with particular emphasis on hexose migrations and the anomeric memory. We discuss challenges and perspectives for future investigations, opening the window to widespread use of glycomics in clinical applications based on a fundamental understanding of glycan fragmentation.}, archive = {J_ANGEW}, author = {Niklas Geue and Marc Safferthal and Kevin Pagel}, doi = {10.1002/anie.202511591}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202511591}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Collision-induced fragmentation of oligosaccharides: Mechanistic insights for mass spectrometry-based glycomics}, volume = {64}, year = {2025}, }
• (2025). Nitrogen-centered organic persistent radicals catalyze redox-neutral C─C bond forming reactions. ANGEW, 64(33), e202511233. (www)

  @article{ , abstract = {We report that nitrogen-centered persistent radicals, Kuhn verdazyls, are effective, tunable ground-state redox organocatalysts for single electron transfer (SET)-initiated radical transformations. Verdazyls uniquely emulate catalytic single-electron shuttling, a hallmark of redox catalysis, without light or external stimuli. They enable redox-neutral C─C bond-forming reactions, such as C─H arylation and C─H trifluoromethylation, typically driven by transition metals, photoredox catalysts, or mechanoredox mediators, while avoiding the self-inhibition that limits organic super electron donors and nitroxides in such applications.}, archive = {J_ANGEW}, author = {Shrouq Mujahed and Jaysan Janabel and Kundan Shaw and Roberta Cagliani and Tynchtyk Amatov}, doi = {10.1002/anie.202511233}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202511233}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitrogen-centered organic persistent radicals catalyze redox-neutral C─C bond forming reactions}, volume = {64}, year = {2025}, }
• (2025). SPLICEIT fluorescent sensor for integrating dopamine release with cellular resolution. ANGEW, 64(33), e202511186. (www)

  @article{ , abstract = {Dopamine is a neurotransmitter essential for motor control, reward processing, and motivation through G-protein coupled receptor (GPCR) signaling. Recent GPCR-based real-time sensors allow for optical monitoring of dopamine release in behaving animals. However, there is still a need for high resolution mapping of dopamine release across large mouse brain volume for systemic studies. To fill this need, we have developed a new chimeric GPCR-based sensor to detect dopamine with a permanent green fluorescent mark through a combination of computational modeling and rational design. This new sensor, named “Single-chain Protein-based Ligand Indication through a Chimerically-Engineered Integrator Tool” (SPLICEIT), detects dopamine at cellular-resolution with high specificity and a fourfold signal-to-background ratio. We also developed a version of SPLICEIT whose signal can be normalized for varying sensor expression in cell culture and in vivo. This paves the way for further studies into dopamine release across the brain and enables the possibility of whole-brain dopamine mapping.}, archive = {J_ANGEW}, author = {Steven M. Havens and Brian Georgis and Jian Weng and Jessi Rodriguez and Hannah Rivett and Shadan Alrawi and Peng Li and Wenjing Wang}, doi = {10.1002/anie.202511186}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202511186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {SPLICEIT fluorescent sensor for integrating dopamine release with cellular resolution}, volume = {64}, year = {2025}, }
• (2025). Electronic structure modulation of Nb2O5 by ru single atoms enabling efficient hydrogen storage of magnesium hydrides. ANGEW, 64(33), e202511139. (www)

  @article{ , abstract = {Magnesium hydride (MgH 2 ) is a promising solid-state hydrogen storage material due to its high capacity and low cost, but its high dehydrogenation temperature and poor kinetic limit its applications. Although catalytic modification of MgH 2 has been extensively studied, existing efforts focus on optimizing hydrogen transfer, with limited exploration of electron transfer and transport. This study investigated the enhancement of electron transfer and transport rates during MgH 2 de/hydrogenation by introducing a single-atom catalyst composed of Ru single atoms on a Nb 2 O 5 substrate. The Ru 0.028 @Nb 2 O 5 single-atom catalyst reduced the peak dehydrogenation temperature of MgH 2 from 429°C to 214 °C, and the activation energies for de/hydrogenation were reduced by 53.7% and 83.9%, respectively. Furthermore, the 15 wt.%-Ru 0.028 @Nb 2 O 5 -MgH 2 composite maintained 97.4% capacity after 100 cycles. Based on excellent performance and theoretical calculations, it was demonstrated that the electronic structure modulation of Nb 2 O 5 by Ru single atoms enhanced the electron transfer and transport capacities, and the synergistic effects of single-atom Ru (dominant role), multivalent Nb, and oxygen vacancies resulted in remarkable catalytic activity. This study offers a new strategy for improving electron transfer and transport by modulating the electronic structure of catalysts, thereby increasing catalytic activity during the solid-state pyrolysis reaction of hydrogen storage materials.}, archive = {J_ANGEW}, author = {Bohua Jia and Jingjing Zhang and Xiaowei Chen and Jiyue Zhang and Baoxin Han and Wentao Wang and Xiaojun Yan and Jianglan Shui and Jianmei Huang}, doi = {10.1002/anie.202511139}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202511139}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic structure modulation of Nb2O5 by ru single atoms enabling efficient hydrogen storage of magnesium hydrides}, volume = {64}, year = {2025}, }
• (2025). Chlorine radical-mediated photocatalytic C─C coupling of methanol to ethylene glycol with near-unity selectivity. ANGEW, 64(33), e202510993. (www)

  @article{ , abstract = {The selective activation of inert C─H bonds in methanol under mild conditions to synthesize high-value C 2 products remains a formidable challenge, primarily due to the competing high reactivity of O─H bonds. Herein, we pioneer a chlorine radical-mediated strategy to redirect the photocatalytic reaction pathway for methanol conversion toward ethylene glycol (EG). Efficient C─H bond activation is achieved by constructing a Z-scheme heterojunction photocatalyst (ZnIn 2 S 4 /TiO 2 -Cl) composed of chlorinated TiO 2 (TiO 2 -Cl) and ZnIn 2 S 4 with efficient charge separation. Photogenerated holes in this system preferentially oxidize surface-adsorbed Cl − to chlorine radicals (Cl•). These radicals drive a thermodynamically favorable hydrogen atom transfer via hydrogen abstraction, cleaving the C─H bond of methanol to form hydroxymethyl radicals (•CH 2 OH). Subsequent C─C coupling of •CH 2 OH intermediates, synergistically combined with a self-sustaining Cl − /Cl• cycle, produces EG with exceptional selectivity (96.7%) and yield (21.6 mmol g −1 ) while suppressing overoxidation. In contrast, nonchlorinated catalysts predominantly utilize photogenerated holes for O─H bond cleavage under identical conditions, yielding only C 1 products (HCHO, HCOOH). This work not only establishes a solar-driven approach for methanol valorization but also advances mechanistic insights into radical-mediated pathway control in heterogeneous photocatalysis.}, archive = {J_ANGEW}, author = {Guang-Xing Dong and Meng-Ran Zhang and Su-Xian Yuan and Min Zhang and Tong-Bu Lu}, doi = {10.1002/anie.202510993}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510993}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chlorine radical-mediated photocatalytic C─C coupling of methanol to ethylene glycol with near-unity selectivity}, volume = {64}, year = {2025}, }
• (2025). Desolvation-induced network reformation and cracking in the single crystals of hydrogen-bonded frameworks composed of tetraazaanthraquinone and anthraquinone derivatives. ANGEW, 64(33), e202510977. (www)

  @article{ , abstract = {A molecular-level understanding of how structural transformations induce morphological changes in organic crystals is essential for developing flexible crystalline materials. Herein, we report that two solvated hydrogen-bonded organic frameworks (HOFs) undergo structural transformations, giving rise to crystal crack propagation in the directions corresponding to their molecular displacements. The HOFs are composed of the tetracarboxylic acids, 4,4′,4″,4′″-(5,10-dioxo-5,10-dihydropyrazino[2,3-g]quinoxaline-2,3,7,8-tetrayl)tetrabenzoic acid ( TAAQ ) and 4,4′,4″,4′″-(9,10-dioxo-9,10-dihydroanthracene-2,3,6,7-tetrayl)tetrabenzoic acid ( AQ ), incorporating tetraazaanthraquinone and anthraquinone cores, respectively. Although TAAQ and AQ have closely similar molecular geometries, their HOFs have entirely different hydrogen-bonded networks. In both HOFs, we found that specific directional hydrogen bonds cleaved, and new hydrogen bonds re-formed, resulting in quasi single-crystal-to-single-crystal transformations. The direction of molecular displacement and crystal cell shrinkage were aligned parallel to the crack propagation. These results contribute to a deeper understanding of the underlying micro–macro property correlations induced by hydrogen-bond cleavage and re-formation.}, archive = {J_ANGEW}, author = {Haruka Kubo and Ryusei Oketani and Ichiro Hisaki}, doi = {10.1002/anie.202510977}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510977}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Desolvation-induced network reformation and cracking in the single crystals of hydrogen-bonded frameworks composed of tetraazaanthraquinone and anthraquinone derivatives}, volume = {64}, year = {2025}, }
• (2025). π-electron donation at the sulfoximidoyl nitrogen atom. ANGEW, 64(33), e202510744. (www)

  @article{ , abstract = {Knowledge of the physicochemical properties and the reactivity of functional groups is invaluable in organic chemistry. Although substantial understanding of properties/reactivities exists for standard functional groups, moieties which have entered the chemist's toolbox more recently are often not as well characterized. Sulfoximines constitute such a class of recently strongly promoted compounds, which nowadays have emerged as relevant molecules in an industrial context and in academic research. However, theoretical studies on the properties of the sulfoximidoyl group remain sparse. The aim of the present work was to investigate the interactions of the sulfoximidoyl nitrogen lone pairs with adjacent π-acceptor orbitals. Density functional theory-based (DFT-based) methods were employed throughout the investigation to quantify the strength of these interactions and to characterize their influence on the properties/reactivities of N -functionalized sulfoximines. Although sulfoximines are commonly characterized as electron-withdrawing, our analysis suggests a strong positive mesomeric effect of the sulfoximidoyl group at nitrogen. This effect increases the basicity and nucleophilicity of conjugated substituents at the sulfoximidoyl nitrogen atom.}, archive = {J_ANGEW}, author = {Benjamin J. Statham and Florian F. Mulks and Carsten Bolm}, doi = {10.1002/anie.202510744}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π-electron donation at the sulfoximidoyl nitrogen atom}, volume = {64}, year = {2025}, }
• (2025). Substrate-adapted active site self-evolving reconfiguration boosting catalytic effect on acetylene semihydrogenation. ANGEW, 64(33), e202510635. (www)

  @article{ , abstract = {The facile synthesis of highly substrate-adapted catalysts with dynamic active site adaptability remains a persistent challenge in heterogeneous catalysis. Herein, breaking through conventional catalyst preparation route of design–synthesis–evaluation iteration, we demonstrate an active site self-evolving reconfiguration strategy for spontaneous construction of an adaptive multimolecular activation catalyst, such as for acetylene semihydrogenation. Specifically, a metastable Cu single atom (Cu 1 ) precursor as structural seed reconstructs to an exceptional acetylene semihydrogenation catalyst under moderate operational conditions, which undergoes a copper active site reconfiguration employing reactants themselves as inducing medium. This self-evolving reconfiguration creates cooperative Cu 1 and Cu nanocluster (Cu n ) ensemble sites with a dynamic active configuration, which is unavailable by conventional thermal reduction methodology, for adaptive multisubstrate H 2 and acetylene activation. Hence, the resulting catalyst achieves full acetylene conversion with 96% ethylene selectivity and robust durability (>30 h) at a record-low temperature of 120 °C, superior to reported copper-based analogues. Such spontaneous active site self-evolving reconfiguration offers a new possibility for intelligent catalyst engineering.}, archive = {J_ANGEW}, author = {Zhong Zhang and Xujiao Ma and Die Zhao and Nana Ma and Jiahui Peng and Songzhu Xing and Shujun Li and Yadong Li and Yiwei Liu}, doi = {10.1002/anie.202510635}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510635}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Substrate-adapted active site self-evolving reconfiguration boosting catalytic effect on acetylene semihydrogenation}, volume = {64}, year = {2025}, }
• (2025). Trigonal planar Bis(carbene)Cu(I) complexes enable divergent h2 activation with H2O for accelerated olefin hydrogenation. ANGEW, 64(33), e202510627. (www)

  @article{ , abstract = {CuH-catalyzed olefin hydrogenation is rare compared to those of carbonyl-derived substrates. Olefin insertion into Cu–H to form Cu-alkyl is ubiquitous; however, subsequent H 2 activation remains unknown to our knowledge. Herein, we investigated the transformations of β-H elimination, H 2 cleavage, and catalytic olefin hydrogenation in a series of linear and trigonal planar Cu(I)-alkyl complexes supported by monodentate N -heterocyclic carbene and bidentate naphthyridine- bis (carbene) ligands, respectively. Contrary to unreactive linear species, trigonal planar variants promote β-H elimination, hydrogenolysis, and catalytic hydrogenation of unactivated alkenes at mild temperatures and H 2 pressure. The rare isolation of a naphthyridine- bis (carbene)CuH monomer further affirms two predominant competing pathways for H 2 cleavage of metal–ligand cooperativity at Cu(I)-alkyl or internal electrophilic substitution at Cu(I)-OH. Employing either isolated or in situ generated Cu(I)-OH complex, via protonolysis of alkyl precatalyst by adventitious water, significantly accelerated catalysis compared to that operating primarily by the metal–ligand cooperativity pathway. DFT calculations and energy decomposition analysis on the disparate β-H elimination reactivity between linear and trigonal planar tert-butyl complexes and the mechanism of H 2 activation at a hydroxide complex, indicate that coordination geometry at Cu(I) and properties of the naphthyridine- bis (carbene) ligand are integral to the transformations reported here.}, archive = {J_ANGEW}, author = {Evan A. Patrick and Shaama Mallikarjun Sharada and Anya Zoraster and Jeremy D. Erickson and David E. Ryan and R. Morris Bullock and Ba L. Tran}, doi = {10.1002/anie.202510627}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Trigonal planar Bis(carbene)Cu(I) complexes enable divergent h2 activation with H2O for accelerated olefin hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Carbocation-based multiresonance thermally activated delayed fluorescent emitters with efficient narrowband electroluminescence. ANGEW, 64(33), e202510511. (www)

  @article{ , abstract = {Multiresonance thermally activated delayed fluorescent (MR-TADF) emitters hold great promise for ultrahigh-definition displays, but are fundamentally restricted to wide-energy-gap heteropolycyclic systems typically with blue-to-green emissions, while their yellow-to-red emissions remain a major challenge. Here we propose a strategy for developing MR-TADF emitters with narrow energy gaps (less than 2.20 eV) by doping positively-charged carbenium ion (C + ) into polycyclic skeletons to create strong short-range charge transfer with electron-rich nitrogen atoms, achieving a significant 160 nm emission redshift compared to the benchmark neutral boron-based counterpart. Furthermore, steric isopropyl groups and bulky tetrakis(pentafluorophenyl)borate counter ions are synergistically integrated to suppress intermolecular aggregation, yielding high solid-state photoluminescence quantum efficiencies up to 90%. Solution-processed organic light-emitting diodes based on the emitters exhibit promising external quantum efficiency of 29.4% with narrow full-width at half-maximum of 0.17 eV, opening the way for development of ion-based MR-TADF emitters toward efficient long-wavelength narrowband electroluminescence.}, archive = {J_ANGEW}, author = {Tao Li and Guimin Zhao and Yuanyuan Li and Kun Lyu and Wenchao Xie and Zhenni Bai and Xinliang Ding and Ronghao Yang and Zhicai Chen and Zhihua Ma and Xin Ai and Wei Jiang and Yanpei Wang and Fangfang Huang and Shiyang Shao}, doi = {10.1002/anie.202510511}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510511}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbocation-based multiresonance thermally activated delayed fluorescent emitters with efficient narrowband electroluminescence}, volume = {64}, year = {2025}, }
• (2025). Controlling the helicity and handedness of polyaromatics with isobenzofuranophane. ANGEW, 64(33), e202510423. (www)

  @article{ , abstract = {The extent of helicity in nonplanar polyaromatic materials affects their electronic, optical and chiroptical properties. However, controlling helicity in different systems typically requires different multistep synthetic approaches for each target compound, often with significant complexity, thereby limiting its applicability. Here, we introduce a helical synthon, isobenzofuranophane, with either a short or long tether, which enables late-stage helicity induction and control in aromatic frameworks. We demonstrate the applicability of this synthon by reacting it with a [5]helicene aryne precursor, where both the handedness and helicene pitch are remotely-controlled by the tether length, directly affecting the (chiro)optical properties of the helicene. The X-ray structures support these findings with up to 35° torsion for a single benzene ring, demonstrating the potential of isobenzofuranophane to induce significant curvature to polyaromatic molecules.}, archive = {J_ANGEW}, author = {Abhijeet R. Agrawal and Israa Shioukhi and Yinon Deree and Benny Bogoslavsky and Ori Shalev and Roy Hoffman and Ori Gidron}, doi = {10.1002/anie.202510423}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510423}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlling the helicity and handedness of polyaromatics with isobenzofuranophane}, volume = {64}, year = {2025}, }
• (2025). Development of a vinylated cyclic allene: A fleeting strained diene for the Diels–Alder reaction. ANGEW, 64(33), e202510319. (www)

  @article{ , abstract = {Fleeting molecules possessing strained multiple bonds are important components in organic synthesis due to their ability to undergo various chemical reactions driven by the release of strain energy. Although the use of strained π-bonds as 2π components, represented by dienophiles in Diels–Alder reactions, has been well studied, “the strained diene (4π component) approach” for molecular construction remains underexplored. Herein, we report the design of a vinyl cyclic allene (1-vinyl-1,2-cyclohexadiene) as a highly reactive strained diene and the development of its Diels–Alder reactions. Experimental and computational studies of vinyl cyclic allenes revealed that this diene system undergoes cycloaddition with dienophiles regio- and stereoselectively under mild reaction conditions. These studies also provide insight into the reactivity and selectivity of the system. The strained diene approach enables the convergent construction of polycyclic molecules through bond disconnections distinct from conventional retrosynthetic analysis, thus offering an efficient strategy for the assembly of functional molecules.}, archive = {J_ANGEW}, author = {Haruki Mizoguchi and Takumi Obata and Taiki Hirai and Manaka Komatsu and Akira Sakakura}, doi = {10.1002/anie.202510319}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510319}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development of a vinylated cyclic allene: A fleeting strained diene for the Diels–Alder reaction}, volume = {64}, year = {2025}, }
• (2025). Rationally designed asymmetric Pt─O─Cu ligand to stabilize active sites towards superior industrial-standard alkaline hydrogen evolution. ANGEW, 64(33), e202510259. (www)

  @article{ , abstract = {Developing efficient and durable Pt-based catalysts via interface engineering remains a critical yet challenging task for water electrolysis under high-pH conditions. Herein, we design a unique asymmetric Pt─O─Cu ligand at the PtCu 2 (111)/CuO(002) heterojunction interface to promote alkaline HER kinetics. This ligand balances the adsorption and desorption of H* on the Pt site by accelerating electron transfer at the interface while enhancing the adsorption of H 2 O on the Cu site. Moreover, the strong d-d/sp hybridization and more delocalized d-DOS located at the Pt─O─Cu ligand enhance the interatomic interactions, which helps alleviate the dissolution and agglomeration of Pt and Cu atoms. As anticipated, the PtCu 2 /CuO requires ultra-low overpotentials of 10, 14 and 47 mV in, respectively, alkaline, acidic and neutral electrolytes to achieve a current density of 10 mA cm −2 . Even more surprising is that the PtCu 2 /CuO||RuO 2 dual-electrode hydrolysis cell can stably operate at a high current density of 1 A cm −2 for more than 500 h in a simulated industrial environment, demonstrating significant potential for industrial applications. This work provides a new paradigm for the design of industrially relevant high-performance Pt-based alkaline hydrogen evolution catalytic materials.}, archive = {J_ANGEW}, author = {Minming Jiang and Jiang Xu and Qi Zhou and Yujie Chen and Paul Munroe and Linlin Li and Zong-Han Xie and Yuping Wu and Shengjie Peng}, doi = {10.1002/anie.202510259}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rationally designed asymmetric Pt─O─Cu ligand to stabilize active sites towards superior industrial-standard alkaline hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Reduction-induced C─C cleavage and site-specific hydrogenation of a highly strained bilayer spironanographene. ANGEW, 64(33), e202510209. (www)

  @article{ , abstract = {The chemical reduction of a bilayer spironanographene, spiro-NG (C 137 H 120 ), with Na and K metals in the presence of [2.2.2]cryptand to yield [Na + (2.2.2-cryptand)](C 137 H 121 − ) ( 1 ) and [K + (2.2.2-cryptand)](C 137 H 121 − ) ( 2 ), respectively, is reported. X-ray crystallography reveals the formation of a new “naked” anion ( spiro-NG H − ), in which spirocyclic ring cleavage and subsequent hydrogenation have occurred. Density Functional Theory (DFT) calculations suggest that the generation of the radical anion of the parent nanographene ( spiro-NG • − ), upon electron acceptance from Na and K metals, induces the cleavage of the strained spirobifluorene core. The resulting spin density localizes on a particular carbon atom, previously attached to the spiranic sp 3 carbon atom, facilitating a site-specific hydrogenation to afford ( spiro-NG H − ). The electrostatic potential map of this anion reveals electron density concentrated at the five-membered ring of the readily formed indenyl fragment, thus enhancing the aromaticity of the system. Furthermore, nuclear magnetic resonance (NMR) and UV–vis absorption spectroscopy experiments allowed to follow the in situ reduction and hydrogenation processes in detail.}, archive = {J_ANGEW}, author = {Juan Lión-Villar and Herdya S. Torchon and Yikun Zhu and Zheng Wei and Jesús M. Fernández-García and Israel Fernández and Marina A. Petrukhina and Nazario Martín}, doi = {10.1002/anie.202510209}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510209}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reduction-induced C─C cleavage and site-specific hydrogenation of a highly strained bilayer spironanographene}, volume = {64}, year = {2025}, }
• (2025). Gram-scale ammonia synthesis via electrochemical nitrate reduction using enzyme-inspired dual-atomic cu catalyst. ANGEW, 64(33), e202510139. (www)

  @article{ , abstract = {The potential application prospects of green electricity-driven electrocatalytic nitrate reduction (NO₃RR) technology for the production of valuable ammonia have garnered widespread attention. However, designing electrocatalysts with remarkable activity and stability for the NO₃RR to realize gram-level ammonia production remains a significant hurdle in terms of practical application. In nature, the synergistic effect of the dual-site copper of nitrite reductase promotes the substrate adsorption and protonation, achieving efficient conversion of nitrite. Herein, enzyme-inspired Cu dual-atomic sites are constructed on polymeric carbon nitride (PCN-Cu-DAC). Systematic investigations indicate the dual-atomic Cu sites in the catalyst exhibit stronger proton transfer and synergistic nitrate adsorption interaction, thereby reducing the energy barrier for *NO protonation. Studies have shown that the PCN-Cu-DAC catalyst presents a remarkable ammonia (NH₃) yield (467 mg h −1 mg −1 cat. and 102 mg h −1 cm −2 ) and achieves 11 g d −1 NH₃ yield at 6 A of current for 360 h. This work demonstrates the concept of mimicking natural nitrite reductase toward the continuous reduction of nitrate wastewater and promotes the production of NH 3 .}, archive = {J_ANGEW}, author = {Qingshuo Li and Yahui Li and Bincheng Xu and Jianping Yang and Ying Wang}, doi = {10.1002/anie.202510139}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510139}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gram-scale ammonia synthesis via electrochemical nitrate reduction using enzyme-inspired dual-atomic cu catalyst}, volume = {64}, year = {2025}, }
• (2025). Dictating zn2+ transport kinetics via versatile ionic covalent organic framework for robust zn metal anodes. ANGEW, 64(33), e202510080. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) offer a promising platform in regulating ion transport and stabilizing electrode–electrolyte interfaces owing to their tailorable porosity and versatile moiety. Compared to widely employed neutral COFs, ionic COFs (iCOFs) harness strong electrostatic interactions to selectively interact with target ions, thereby helping accelerate ion-pair dissociation. Furthermore, the charged backbones of iCOFs induce interlayer electrostatic repulsion, driving spontaneous exfoliation and hence promoting ion transport kinetics. Capitalizing upon these advantages, we in situ engineer a low-crystallinity iCOF interfacial membrane over Zn anode. The guanidinium moieties within the framework immobilize water molecules through H-bond interactions, effectively suppressing parasitic side reactions. Concurrently, coulombic interactions between the positively charged backbone and SO 4 2− facilitate Zn 2+ dissociation, enabling stable ion transport and uniform Zn deposition. Benefiting from the improved electrochemical stability of modified Zn anode, the as-assembled Zn metal pouch cell delivers a reversible capacity of ∼0.35 Ah g −1 with a 98.72% capacity retention over prolonged cycling. This work establishes a paradigm for leveraging iCOFs to regulate Zn 2+ transport kinetics toward next-generation energy storage systems.}, archive = {J_ANGEW}, author = {Yuhan Zou and Yongbiao Mu and Tian Wang and Ziang Chen and Zixiong Shi and Wenyi Guo and Tong Shen and Zixiang Meng and Jiyun Hu and Lin Zeng and Tao Liu and Jingyu Sun}, doi = {10.1002/anie.202510080}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510080}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dictating zn2+ transport kinetics via versatile ionic covalent organic framework for robust zn metal anodes}, volume = {64}, year = {2025}, }
• (2025). Electrochemical enantioselective oxidation of indoles via chiral phosphoric acid catalysis in cooperation with H3PO4 in aqueous media. ANGEW, 64(33), e202510078. (www)

  @article{ , abstract = {Disclosed here is the first catalytic enantioselective electrochemical oxidative rearrangement of indoles for the efficient synthesis of highly enantioenriched spirooxindoles. The in-situ generated HBr from substrate oxidation, known to be detrimental to the reaction itself, was perfectly consumed by cathode reduction. Challenges of this process include the difficulty in maintaining the synergy between substrate oxidation and cathode reduction as well as the general incompatibility of a hydrogen bonding catalytic system with the aqueous acidic media. A monophasic system was initially developed, but with little substrate generality. Further analysis of the mechanism and careful optimization allowed the development of a much more general and robust biphasic system that exhibited multiple advantages over chemical oxidation, including broader scope, less waste, milder conditions, and better enantioselectivity. It is also the first demonstration of chiral phosphoric acid catalysis in cooperation with H 3 PO 4 in acidic aqueous media.}, archive = {J_ANGEW}, author = {Xuefeng Tan and Zhijie Zhou and Minhua Shao and Jianwei Sun}, doi = {10.1002/anie.202510078}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510078}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical enantioselective oxidation of indoles via chiral phosphoric acid catalysis in cooperation with H3PO4 in aqueous media}, volume = {64}, year = {2025}, }
• (2025). Absolute asymmetric synthesis of a homochiral polymer from an achiral monomer. ANGEW, 64(33), e202510058. (www)

  @article{ , abstract = {A compelling hypothesis for the origin of homochirality that led to the origin of life is that a chiral informational polymer, formed somehow from achiral monomers, biased the early chemical events, leading to the exclusive synthesis of chiral building blocks of life. However, the formation of a chiral polymer from achiral monomers continues to be a mystery. We exploited the ability of achiral molecules to rarely crystallize in chiral space groups to design achiral monomers for topochemical polymerization to obtain chiral polymers. One such achiral monomer synthesized, viz. a tripeptide monomer containing alkene and azide at its termini, crystallized in a chiral space group, forming a conglomerate as revealed by single-crystal X-ray diffraction. Upon heating at a temperature above 70 °C, each enantiomorphic crystal underwent a regiospecific and stereospecific topochemical ene-azide cycloaddition reaction in a single-crystal-to-single-crystal fashion to give a triazoline-linked homochiral helical polymer. We characterized several homochiral polymer crystals at atomic resolution either by SCXRD or by 3D electron diffraction.}, archive = {J_ANGEW}, author = {Divina Xavier and Sourav Pathak and Christian R. Göb and Kana M. Sureshan}, doi = {10.1002/anie.202510058}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202510058}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Absolute asymmetric synthesis of a homochiral polymer from an achiral monomer}, volume = {64}, year = {2025}, }
• (2025). Automated iterative N─C and C─C bond formation. ANGEW, 64(33), e202509974. (www)

  @article{ , abstract = {Small molecule solutions to many contemporary societal challenges await discovery, but the artisanal and manual process via which this class of chemical matter is typically accessed limits the discovery of new functions. Automated assembly of (N-methyl iminodiacetic acid) MIDA or (tetramethyl N-methyl iminodiacetic acid) TIDA boronate building blocks via iterative C─C bond formation, an approach we call “block chemistry”, alternatively enables generalized and automated preparation of many different types of small molecules in a modular fashion. But in its current form, this engine cannot also leverage nitrogen atoms as iteration handles. Here, we disclose a new iteration-enabling group, CbzT ( p- TIDA boronate-substituted carboxybenzyl), that reversibly attenuates the reactivity of nitrogen atoms and enables generalized catch-and-release purification. CbzT is leveraged to achieve the automated modular synthesis of Imatinib (Gleevec), an archetypical clinically approved kinase inhibitor, in which building blocks are iteratively linked by both N─C and C─C bonds. This work substantially expands the types of small molecules that can be iteratively assembled in an automated modular fashion. It also advances the concept of intentionally developing chemistry that machines can do.}, archive = {J_ANGEW}, author = {Theodore Tyrikos-Ergas and Sevasti Agiakloglou and Antonio J. LaPorte and Wesley Wang and Chieh-Kai Chan and Clare E. Wells and Christopher K. Rakowski and Rachel I. Hammond and Jia Qiu and Jonathan D. Raymond and Tiago Vieira and John Limanto and Marc N. Feiglin and Daniel J. Blair and Martin D. Burke}, doi = {10.1002/anie.202509974}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509974}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Automated iterative N─C and C─C bond formation}, volume = {64}, year = {2025}, }
• (2025). Internally BN-doped coronene. ANGEW, 64(33), e202509971. (www)

  @article{ , abstract = {We present the first synthesis of internally BN-doped coronenes ( B2N2-C , H-B2N2-C , and 2H-B2N2-C ) with two covalent B─N units embedded on the central axis of coronene. The B─N doping leads to unique electronic structures with distinct charge distribution, conjugation, aromaticity, and photophysical properties. The structures were successfully identified by the single-crystal X-ray scattering. B2N2-C without sidechains retains the structure of coronene but exhibits stronger π–π stacking, higher electronic coupling, and a narrowed solid-state bandgap. Driven by the B─N dipole–dipole interaction, all B2N2-coronene derivatives exhibit more ordered assembly with excimer emission in solution, which is absent in coronene. Notably, two stable polymorphs emerge in single crystals of 2H-B2N2-C with two hexyl chains: a kinetically stable rod phase and a thermodynamically stable plate phase, where variations in processing conditions direct the formation of different phases.}, archive = {J_ANGEW}, author = {Jing-Cai Zeng and Xuan-Yu Song and Ze-Fan Yao and Yong-Shi Chen and Yu-Chun Xu and Kexiang Zhao and Yi Liu and Jie-Yu Wang and Jian Pei}, doi = {10.1002/anie.202509971}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509971}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Internally BN-doped coronene}, volume = {64}, year = {2025}, }
• (2025). Backbone protecting groups for enhanced peptide and protein synthesis. ANGEW, 64(33), e202509939. (www)

  @article{ , abstract = {Solid-phase peptide synthesis has become an indispensable technique for the routine preparation of linear peptides of up to approximately 40 amino acids in length. However, the solid-phase approach is still hampered by chain insolubility and aggregation, which reduces synthetic yields. Moreover, many of the deletion impurities that can form are often chromatographically inseparable from the target sequence, which diminishes final product purity. The use of backbone N -protecting groups can ameliorate this synthetic inefficiency by increasing peptide chain solubility and suppressing aggregation. Backbone protection is also useful for promoting peptide macrocyclization, suppressing common side reactions in peptide chemistry, and improving solution-phase handling. Commercially available precursors containing benzyl-based groups and pseudoprolines have found widespread use, in academic laboratories and industry. A range of other strategies have also been investigated in a bid to increase the utility of backbone protecting groups and to develop more efficient methods for their introduction and removal. This review provides a comprehensive account of the state of the art, and includes detailed synthetic methods relating to the use of backbone protection, and its application to “difficult” peptides and proteins of biological significance. The strengths and weaknesses of each approach are analyzed, and a commentary on future directions is provided.}, archive = {J_ANGEW}, author = {Samuel J. Paravizzini and Linda M. Haugaard-Kedström and Craig A. Hutton and John A. Karas}, doi = {10.1002/anie.202509939}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509939}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Backbone protecting groups for enhanced peptide and protein synthesis}, volume = {64}, year = {2025}, }
• (2025). Nanoconfined polymerization facilitates efficient li+ transportation in quasi-solid electrolytes. ANGEW, 64(33), e202509921. (www)

  @article{ , abstract = {Conventional gel polymer electrolytes (GPEs) struggle with lithium dendrite growth and long-term cycling stability due to low ionic conductivity. A nanoconfined polymerization (NCP) strategy was employed to develop a composite GPE (PDA@CityU-43) comprising porous COF and linear polymers. The crosslinked polymer chains are confined within the nanopores of CityU-43 along c -direction, improving polymer distribution and filler-polymer compatibility. The PDA@CityU-43 achieves a high ionic conductivity (6.02 × 10 −3 S cm −1 at 25 °C) and a high Li + transference number (0.82), which is favorable to enhance Li + transport dynamics and induce uniform Li + deposition. Thus, the Li||Li cell can stably operate over 6000 h at 0.1 mA cm −2 and 0.1 mAh cm −2 . The Li||PDA@CityU-43||LFP demonstrates significantly improved cycling stability at 5C, a reversible capacity of 108 mAh/g after 300 cycles. The Li||PDA@CityU-43||NCM 811 cells with high mass loading (∼5.8 mg cm −2 ) exhibits 72.5% capacity retention after 100 cycles. This NCP strategy offers a new approach to designing advanced GPEs for Li metal batteries.}, archive = {J_ANGEW}, author = {Tuoya Naren and Qianfeng Gu and Ruheng Jiang and Yanwei Zhao and Lei Zhang and Antai Zhu and Xiang Wang and Jinghang Wu and Zongmin Zheng and Chun-Sing Lee and Gui-Chao Kuang and Libao Chen and Fu-Rong Chen and Qichun Zhang}, doi = {10.1002/anie.202509921}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509921}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanoconfined polymerization facilitates efficient li+ transportation in quasi-solid electrolytes}, volume = {64}, year = {2025}, }
• (2025). Synthesis and physical properties of [n]Cycloparaphenylene ketone (n = 6, 7, 8, and 10). ANGEW, 64(33), e202509754. (www)

  @article{ , abstract = {[ n ]Cycloparaphenylene ketone 4 , [ n ]CPP-CO, in which a carbonyl group is inserted into [ n ]CPP framework, with n = 6, 7, 8, and 10, was synthesized by a coupling reaction between a CPP precursor and a ketone unit, followed by reductive aromatization. Single crystal X-ray diffraction analysis and density functional theory (DFT) calculations confirmed their Möbius topology and significant molecular strain as characterized by the deviations in bond angles at the carbonyl carbon. The strain was also evidenced by size-dependent 20–50 cm −1 shifts in the carbonyl IR stretching bands. The CPP units in 4 significantly alter the electronic properties, particularly the relative orbital energies. Due to the elevation of the energy level of the occupied π-orbitals by CPP units, the highest occupied molecular orbital (HOMO) in 4 is the conjugated π-system, in contrast to benzophenone, where the HOMO is the non-bonding n-orbital. Consequently, the lowest excited state of 4 is the singlet state (S 1 ) with π–π* character rather than the conventional n–π* triplet (T 1 ) state. Furthermore, intersystem crossing from the S 1 state to the T 1 state, which is a characteristic process for typical aromatic ketones, does not occur efficiently. As a result, 4 exhibits unique photophysical properties opposite to those of typical aromatic ketones, such as fluorescing but not phosphorescing. Furthermore, the S 1 state of 4 was quenched by molecular oxygen, most likely by the energy exchange mechanism. Optical and electrochemical properties showed a clear dependence on ring size, with smaller rings exhibiting greater strain, lower oxidation potentials, and red-shifted absorption and emission. These findings highlight the unique interplay between molecular topology, strain, and photophysics in CPP-based ketones and provide a foundation for designing novel π-conjugated materials with tailored excited-state properties.}, archive = {J_ANGEW}, author = {Eiichi Kayahara and Ryota Okahara and Amiri Shibata and Manabu Abe and Shigeru Yamago}, doi = {10.1002/anie.202509754}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509754}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and physical properties of [n]Cycloparaphenylene ketone (n = 6, 7, 8, and 10)}, volume = {64}, year = {2025}, }
• (2025). Identifying the role of pt active species in CO-sensitive photocatalytic h2 evolution. ANGEW, 64(33), e202509693. (www)

  @article{ , abstract = {Platinum (Pt) has been widely employed in photocatalytic H 2 production. However, the influence of CO on proton reduction to H 2 over Pt active species remains unknown. Herein, using Pt/Nb 2 O 5 as a model catalyst, the role of Pt active species in CO-sensitive photocatalytic H 2 evolution is evaluated. Our results reveal that Pt 4+ species exhibits superior activity in H 2 production when the CO-to-Pt molar ratio is low ( n CO / n Pt ≤ 1.3), but their photocatalytic performance is suppressed at a high n CO / n Pt ratio (>1000). By contrast, increasing the loading amount of Pt suppresses Pt 4+ species formation and the low valence state Pt species show inferior activity for H 2 production, which is almost unaffected by the n CO / n Pt ratio. The CO-TPD results, in situ FTIR spectra, and DFT calculations indicate that the role of adsorbed CO molecules is to impede the interaction between H 2 O and Pt 4+ species and prevent the generation of *H species for H 2 production. Significantly improving the H 2 production rate by purging with argon suggests the importance of inhibiting the adsorption of CO on Pt 4+ species. This study sheds light on the generation and transformation of active H species in CO-participated photocatalytic systems, which is missing in previous works, and is more significant for rationally designing Pt-based photocatalysts in large-scale H 2 production.}, archive = {J_ANGEW}, author = {Kaiyi Su and Tengshijie Gao and Haixia Liu and Shuai Zhou and Chen Zhang and Ke Zhang and Can Li and Jintao Ru and Wangsheng Chu and Chen-Ho Tung and Li-Zhu Wu}, doi = {10.1002/anie.202509693}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509693}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identifying the role of pt active species in CO-sensitive photocatalytic h2 evolution}, volume = {64}, year = {2025}, }
• (2025). Highly efficient Suzuki–Miyaura polymerization enabled by direct transmetalation with boronic esters. ANGEW, 64(33), e202509672. (www)

  @article{ , abstract = {The Suzuki–Miyaura cross-coupling reaction plays a pivotal role in the construction of carbon–carbon bonds, utilizing low-toxicity and readily available organoboron substrates. However, competitive protodeboronation of arylboronic acids has significantly limited its synthetic applications, particularly in the synthesis of optoelectronic polymer materials. Herein, a novel sulfonium salt-mediated Suzuki–Miyaura cross-coupling protocol is developed to synthesize high-quality π-conjugated polymers (CPs). The universality of this method was exemplified by successfully synthesizing twelve CPs with various electrophiles and nucleophiles. Impressively, the synthesized CPs exhibited enhanced optoelectronic properties, e.g., charge carrier mobilities, compared to those synthesized by traditional methods. Experimental and theoretical investigations revealed that direct transmetalation of boronic esters without prior conversion to more reactive intermediates play a critical role in this protocol, thus avoiding the problematic deboronation associated with unstable boronic acids. This method provides an environmentally benign approach to synthesize device-quality CPs.}, archive = {J_ANGEW}, author = {Haigen Xiong and Yu Lu and Qijie Lin and Yuke Xie and Fujun Guo and Meng Zhang and Xin Zhang and Qinqin Shi and Hui Huang}, doi = {10.1002/anie.202509672}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509672}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient Suzuki–Miyaura polymerization enabled by direct transmetalation with boronic esters}, volume = {64}, year = {2025}, }
• (2025). A combined aptamer pulldown-DNAzyme cleavage assay for intact methicillin resistant staphylococcus aureus cells. ANGEW, 64(33), e202509598. (www)

  @article{ , abstract = {Accurate and convenient detection of methicillin resistant Staphylococcus aureus (MRSA) plays a vital role in determining appropriate antibiotic interventions. Herein, we report the first example combining a DNA aptamer and an RNA-cleaving DNAzyme (RCD) that bind different protein markers for selective preconcentration and detection of MRSA. An aptamer for the penicillin binding protein 2a (PBP2a) was generated by in vitro selection and was coupled to agarose beads to allow rapid pull down of intact MRSA cells from complex samples. A previously reported RCD for Staphylococcus aureus (SA) was then used to detect a second proteinaceous marker within the lysed cells based on a protein-activated cleavage reaction that was linked to both fluorescence and lateral flow assays, allowing for selective detection of MRSA over methicillin sensitive SA. An optimized LFD assay could detect ∼10 3 cfu mL −1 of MRSA in either nasal mucus or serum with a total assay time of 1 h using minimal sample processing.}, archive = {J_ANGEW}, author = {Monsur Ali and Abigail F. Almeida and Dawn White and Alfredo Capretta and John D. Brennan}, doi = {10.1002/anie.202509598}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509598}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A combined aptamer pulldown-DNAzyme cleavage assay for intact methicillin resistant staphylococcus aureus cells}, volume = {64}, year = {2025}, }
• (2025). Modular assembly of B(III)-coordinated fluorophores with quantitatively predictable photoinduced electron transfer for chemosensing and bioimaging. ANGEW, 64(33), e202509567. (www)

  @article{ , abstract = {Photoinduced electron transfer (PeT), a foundational mechanism for constructing stimuli-responsive fluorescent probes, faces persistent challenges, including the lack of generalizable quantitative models, limited systematic case studies, signal interference, and synthetic complexity. Herein, we propose a boron-centric PeT molecular engineering strategy that harnesses the unique tetrahedral coordination geometry of B(III) centers. This approach leverages the programmable nature of boron coordination chemistry to precisely tailor dye electronic energy levels and photophysical properties. Using dipyrromethane as a core scaffold and modulating boronic acid coordination with diverse nucleophiles (such as alcohols, phenols, and carboxylic acids), we developed a modular, multicomponent one-pot synthesis platform for efficient assembly of B-PeT dyes. Extending this strategy to pyrrolyldipyrrin and dipyrrolyldipyrrin scaffolds achieved the synthesis of near-infrared (NIR) B-PeT dyes. A library of 75 B(III)-derivatives was synthesized and characterized to enable systematic elucidation and predictive modeling of structure-PeT activity relationships, providing mechanistic insights to guide mitigation of PeT signal interference. The engineered B-PeT probes exhibit superior performance in photoactivated imaging and lysosomal pH sensing, highlighting their translational potential. Our work establishes boron coordination chemistry as a modular toolkit for rational PeT probe design, offering scalable molecular platforms for next-generation sensors with enhanced functionality and synthetic efficiency.}, archive = {J_ANGEW}, author = {Heng Li and Luying Guo and Wei Miao and Zhaoyun Wang and Zhengxin Kang and Shaozhen Wang and Xing Guo and ChangJiang Yu and Lijuan Jiao and Erhong Hao}, doi = {10.1002/anie.202509567}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509567}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular assembly of B(III)-coordinated fluorophores with quantitatively predictable photoinduced electron transfer for chemosensing and bioimaging}, volume = {64}, year = {2025}, }
• (2025). Advancing sulfinyl radical chemistry: An asymmetric smiles rearrangement with chiral sulfoxides. ANGEW, 64(33), e202509470. (www)

  @article{ , abstract = {Chiral N-sulfinyl amides have recently emerged as powerful reagents for asymmetric, radical-mediated Smiles rearrangements, imparting excellent levels of relative and absolute stereocontrol in the intra- and intermolecular translocation of aryl groups. Here, we capitalize on the much more readily available and abundant chiral sulfoxides, which, in combination with radical precursors and alkylating reagents, afford enantioenriched sulfur-containing molecules via a photocatalytic multicomponent asymmetric sulfinyl-Smiles rearrangement with retention of “SO”. This cascade process involves radical addition, a stereocontrolled 1,5-aryl migration, and subsequent C─S bond formation, forging two new C─C bonds and a C─S bond in a single step under mild conditions. The resulting enantioenriched sulfur-containing scaffolds are not only common in pharmaceuticals and bioactive compounds but also serve as versatile synthetic intermediates, as demonstrated by their efficient derivatization into diverse motifs.}, archive = {J_ANGEW}, author = {Yawen Hu and Till Schreyer and Cristina Nevado}, doi = {10.1002/anie.202509470}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509470}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Advancing sulfinyl radical chemistry: An asymmetric smiles rearrangement with chiral sulfoxides}, volume = {64}, year = {2025}, }
• (2025). A universal metal ion-targeting coordination strategy for precise synthesis of heteronuclear dual-atom electrocatalysts for oxygen reduction. ANGEW, 64(33), e202509360. (www)

  @article{ , abstract = {Heteronuclear dual-atoms catalysts (DACs) represent an emerging frontier in heterogeneous catalysis due to maximum atom utilization and synergistic catalysis, yet their precise synthesis remains challenging. Herein, we propose a universal “metal ion targeting coordination” (MITC) strategy to construct a series of heteronuclear DACs. This approach utilizes the bipyridyl (bpy) ligands to coordinate a primary metal (M 1 ), forming an artificial monooxygenase (bpy)M 1 ( μ 2 -OH) structure, where electron-enriched oxygen atoms serve as anchoring sites for a secondary metal (M 2 ). The oxygen bridged M 1 -O-M 2 configurations in the resulting (bpy)M 1 ( μ 2 -OH)M 2 precursors enable precise synthesis of heteronuclear DACs during the subsequent pyrolysis. Benefiting from geometric and electronic structure merits, heteronuclear DACs can efficiently catalyze oxygen reduction reaction (ORR) through a more desirable dissociative mechanism, thus circumventing the inherent OH*-OOH* linear scaling relations. Notably, the FeCo DAC exhibits exceptional ORR performance, with an onset and half-wave potential of 1.03  and 0.93 V, respectively. The excellent ORR activity of FeCo DAC is further validated in anion-exchange membrane fuel cells (AEMFCs), delivering a peak power density over 1.3 W cm −2 and a current density of 79.2 mA cm −2 at 0.9 V iR-free under H 2 -O 2 conditions.}, archive = {J_ANGEW}, author = {Xue Wang and Youze Zeng and Pengbo Wang and Xukai Wang and Kai Li and Lanlu Lu and Jianbing Zhu and Changpeng Liu and Meiling Xiao and Wei Xing}, doi = {10.1002/anie.202509360}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509360}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A universal metal ion-targeting coordination strategy for precise synthesis of heteronuclear dual-atom electrocatalysts for oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). Direct activation of sulfides by C–H oxidation with photoexcited nitroarenes: Formal manipulations of the C─S bond. ANGEW, 64(33), e202509244. (www)

  @article{ , abstract = {The sulfide motif is distributed widely across chemical and biological space. In synthesis, its installation often marks the end point of a sequence, due to its relative inertness; sulfides typically require direct oxidation of sulfur before they are receptive toward transformation. Unfortunately, selective S-oxidation is not always straightforward, with the need for oxidants lacking chemoselectivity in the presence of functionality and delivering mixtures of oxidation products. This multistep manipulation of the sulfide motif, initiated by direct S-oxidation, limits the use of sulfides as synthetic handles for downstream manipulation. Herein, we describe a direct activation of sulfides by C–H oxidation alpha to sulfur—rather than traditional oxidation at sulfur—that facilitates efficient formal C─S bond manipulation. The mild nature of the photo-induced anaerobic oxidation protocol enables its merger with high-value transformations in telescoped or one-pot protocols that deliver branched amines, secondary alcohols, and alkenes from aldehyde and ketone intermediates. The method expands the chemistry of sulfides by diverting reactivity away from sulfur (oxidation, alkylation) and instead targeting directly the alpha position, resulting in formal manipulation of the C─S bond, and redefining sulfides as latent synthetic handles to be “switched on” at will.}, archive = {J_ANGEW}, author = {Valentina D. Cuomo and Ciro Romano and David J. Procter}, doi = {10.1002/anie.202509244}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509244}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct activation of sulfides by C–H oxidation with photoexcited nitroarenes: Formal manipulations of the C─S bond}, volume = {64}, year = {2025}, }
• (2025). Correspondence on “Suppressing energy migration via antiparallel spin alignment in one-dimensional mn2+ halide magnets with high luminescence efficiency”. ANGEW, 64(33), e202509184. (www)

  @article{ , abstract = {The photoluminescence quantum yield (PLQY) of tetramethyl ammonium manganese(II) chloride, (CH 3 ) 4 NMnCl 3 (TMMC), doped with Cd 2+ /Cu 2+ is analyzed through photoluminescence measurements, X-ray diffraction, optical absorption, and time-resolved excitation and emission under hydrostatic pressure. Contrary to recent studies reporting a PLQY increase up to x = Cd x /Mn 1-x = 0.08 followed by a decline (from 95% to 77% at x = 0.22), 1 we demonstrate that the PLQY remains consistently high (≥95%) across the concentration range x = 0–0.22.}, archive = {J_ANGEW}, author = {Fernando Rodríguez}, doi = {10.1002/anie.202509184}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509184}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correspondence on “Suppressing energy migration via antiparallel spin alignment in one-dimensional mn2+ halide magnets with high luminescence efficiency”}, volume = {64}, year = {2025}, }
• (2025). Controlling asymmetry amplification through supramolecular polymorphism. ANGEW, 64(33), e202509031. (www)

  @article{ , abstract = {Supramolecular polymorphism has recently emerged as a powerful concept, enabling a single chemical entity to form distinct, stable assemblies in solution with diverse morphological, photophysical, and electronic properties. Despite this progress, the interplay between supramolecular polymorphism and chirality remains unexplored. Herein, we harness supramolecular polymorphism to control the amplification of asymmetry in supramolecular polymerization (SP). For this purpose, we designed two Pt(II) complexes bearing π -extended ligands and S - or R -chiral side chains (compounds ( S )-1 and ( R )-1 ) that self-assemble into two distinct supramolecular polymorphs in methylcyclohexane: nonemissive short fibers with parallel molecular packing ( AggI ) and thermodynamically more stable helical fibers with a rotationally offset stacking, closer Pt⋯Pt contacts, and weak 3 MMLCT luminescence ( AggII ). These polymorphs exhibit markedly different amplification of asymmetry in majority rules ( MR ) and sergeants-and-soldiers ( SaS ) studies, with the thermodynamic polymorph displaying superior performance. Ultimately, coassembly studies between the achiral model compound 2 —which exhibits strong 3 MMLCT emission in the assembled state—and the chiral but weakly emissive AggII reveal a synergistic communication between chirality and luminescence, culminating in the emergence of circularly polarized luminescence (CPL). This study broadens the scope of supramolecular polymorphism and expands the design toolbox for adaptive supramolecular materials with emergent and synergistic functionalities.}, archive = {J_ANGEW}, author = {Camila Montañez-Moyano and Yuncong Xue and María Victoria Cappellari and Alejandro Martínez-Manjarrés and Lorenz Borsdorf and Cristian A. Strassert and Gustavo Fernández}, doi = {10.1002/anie.202509031}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202509031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlling asymmetry amplification through supramolecular polymorphism}, volume = {64}, year = {2025}, }
• (2025). HCl intake via nanobubbles induces redox radicals for aqueous cl2 and h2 production without catalyst and bias applied. ANGEW, 64(33), e202508947. (www)

  @article{ , abstract = {Bubbling is a widely used method to enhance gas hydration and dissolution in aqueous solutions. Understanding the bubble-induced interface-rich aqueous system is crucial for elucidating gas-involved solution chemical reactions, yet this area remains underexplored. Here we report the formation of aqueous Cl 2 and H 2 driven by nanobubbles, achieved by introducing redox-active HCl gas through a gas diffusion electrode without applying bias or loading catalysts. Electron paramagnetic resonance (EPR) revealed that increasing HCl intake elevates the concentration of hydroxyl radical (·OH) and hydrated electrons (e − aq ), more than an order of magnitude higher than that of feeding Ar alone. High-resolution mass spectrometry identified spin-trapping agent stabilized radical intermediates, including ·Cl, ClO·, and ·H. Iodometric titration estimated the equivalent Cl 2 content at approximately 18 mmol L −1 , while gas chromatography verified H 2 formation. This study demonstrates that bubbling redox-active gases through aqueous solution can activate water reactivity, leading to the conversion of the gases themselves.}, archive = {J_ANGEW}, author = {Ruijuan Zhao and Lei Li and Di Wu and Wei Luo and Chaowei Peng and Mengjun Xiao and Chunhua Cui}, doi = {10.1002/anie.202508947}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508947}, shortjournal = {Angew. Chem. Int. Edit.}, title = {HCl intake via nanobubbles induces redox radicals for aqueous cl2 and h2 production without catalyst and bias applied}, volume = {64}, year = {2025}, }
• (2025). Supramolecular assembly-driven multilevel fluorescent encryption. ANGEW, 64(33), e202508935. (www)

  @article{ , abstract = {The growing demand for information security in the digital era has accelerated the development of novel encryption materials, among which optically responsive systems have emerged as particularly promising candidates due to their exceptional tunability and noninvasive characteristics. However, current optical encryption materials remain largely confined to static or binary states, presenting a fundamental challenge in achieving precisely controlled hierarchically responses for developing high-capacity, multilevel encrypted materials. Herein, we successfully construct a novel class of dynamically multilevel responsive luminescent materials driven by supramolecular self-assembly and apply them to a multilevel information encryption system. The highly efficient host–guest complexation between 4-phenylpyridine-functionalized isoquinoline derivatives (IQP) and macrocyclic molecule CB[8] enables the construction of linear supramolecular polymers (IQP⊂CB[8]). Affected by the dynamic protonation of isoquinoline and the host–guest interaction, the monomer and polymer exhibit the characteristics of multicolor luminescence. Furthermore, IQP can undergo a reversible [2+2] photocycloaddition reaction in the confined space of CB[8], it can reversibly transform from a conjugated supramolecular polymer to a nonconjugated polyrotaxane and shows pronounced optical response on the time gradient. Consequently, this light, heat, acid/base-sensitive supramolecular system exhibits reversible responsiveness and time-dependent characteristics, thereby establishing a multichannel fluorescent cascade encryption platform capable of multilevel information encryption.}, archive = {J_ANGEW}, author = {Ming Liu and Honggang Mei and Yanfang Wang and Mengbin Wang and Zhenxing Cui and Guangfeng Li}, doi = {10.1002/anie.202508935}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508935}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular assembly-driven multilevel fluorescent encryption}, volume = {64}, year = {2025}, }
• (2025). Regulating structures and properties of overcrowded-ethylene decorated (Diaza)Phosphinines via tunable main-group element hyperconjugation. ANGEW, 64(33), e202508880. (www)

  @article{ , abstract = {Creating more sophisticated molecular systems that are responsive, dynamic, and controllable through a combination of chemical structure modification and external stimuli represents a pivotal challenge in the development of functional molecular machines. Herein, we report a new series of overcrowded-ethylene (OCE) decorated (diaza)phosphinines. Combining with the main-group element and nonplanar OCE structures, new P-molecules showed the tunable folded(F)/twisted(T)-conformations and physical properties via the distinct P-hyperconjugation of the P─C and P─N bonds. Such hyperconjugation-induced tunability is different from the classical OCEs where p-π/π-π conjugation effects are the dominating factors controlling the structures and properties. Furthermore, bromination of NP-oxide derivative induced an unexpected chemochromic T→F isomerization, highlighting the dynamic conformation character. Leveraging on the different structures, CP and NP derivatives further enabled the formations of radical cations and anions having different spin characters on the P-centers. As the new example of P-Thiele's hydrocarbon family, combining the NP structure with the overcrowded anthraquinodimethane structure yielded a light-responsive open-shell NP-anthraquinodimethane diradicaloid with a triplet ground state, which was influenced by the PN hyperconjugation effect in F-conformation and the aromaticity gain in T-conformation. Overall, our new strategy, namely the hyperconjugation-regulated tunability, paves the way toward complex organic materials with tunable the structures and physical properties.}, archive = {J_ANGEW}, author = {Zhaoxin Liu and Zi Yang and Chao Li and Huanchao Gu and Xinyu Li and Yi Ren}, doi = {10.1002/anie.202508880}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508880}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating structures and properties of overcrowded-ethylene decorated (Diaza)Phosphinines via tunable main-group element hyperconjugation}, volume = {64}, year = {2025}, }
• (2025). Enantioselective de novo construction of pyran-2-one-fused helicenoids via NHC organocatalysis. ANGEW, 64(33), e202508789. (www)

  @article{ , abstract = {Helicenoids have attracted considerable interest in diverse research areas owing to their unique structural and electronic characteristics. However, catalytic asymmetric synthesis of helically chiral molecules has remained a formidable challenge. In particular, the organocatalytic enantioselective construction of heterohelicenoids has witnessed fairly limited progress, presumably due to the lack of rational design of competent substrates, the right choice of suitable reactions, and highly effective catalytic systems. In this study, we report the helicoselective and divergent synthesis of a new class of pyran-2-one-fused [5]helicenoids and [4]helicenoids through an NHC organocatalytic step-economical (3+3) annulation reaction. The protocol features broad substrate scope, ease of late-stage functionalization, and excellent stereo-control with enantioselectivities up to >99%. Moreover, the optical properties of the synthesized oxohelicenoids and their derivatives were characterized to explore their potential applications in material sciences.}, archive = {J_ANGEW}, author = {Chenxing Li and Jianquan Feng and Zuquan Liu and Menghan Xu and Jie Feng and Ding Du}, doi = {10.1002/anie.202508789}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508789}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective de novo construction of pyran-2-one-fused helicenoids via NHC organocatalysis}, volume = {64}, year = {2025}, }
• (2025). Recyclable quasi-homogeneous carbon nitride colloidal catalyst for sustainable photocatalytic H2O2 generation. ANGEW, 64(33), e202508718. (www)

  @article{ , abstract = {Graphitic carbon nitride (g-C 3 N 4 ) photocatalysts have attracted growing interest for the eco-friendly, solar-driven synthesis of hydrogen peroxide (H 2 O 2 ). However, the catalytic efficiency remains limited by poor accessibility of reactive sites due to the hydrophobic nature and aggregation tendency of conventional g-C 3 N 4 . Here, we report a hydrophilic g-C 3 N 4 colloidal photocatalyst, synthesized via potassium ion (K⁺) incorporation and surface grafting with sulfonylcyanide groups, which enables quasi-homogeneous photocatalytic H 2 O 2 production (7,886 µmol g⁻¹ h⁻¹), surpassing most reported g-C 3 N 4 -based heterogeneous systems. The sulfonylcyanide groups facilitate O 2 adsorption and reduction, while synergistically promoting charge separation in conjunction with K⁺ ions. This work demonstrates the potential of hydrophilic g-C 3 N 4 colloids in quasi-homogeneous catalysis and presents a versatile strategy for designing advanced g-C 3 N 4 -based photocatalysts for sustainable chemical synthesis.}, archive = {J_ANGEW}, author = {Lian-Lian Liu and Chao Cui and Fei Chen and Jie-Jie Chen and Han-Qing Yu and Yujie Xiong}, doi = {10.1002/anie.202508718}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508718}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Recyclable quasi-homogeneous carbon nitride colloidal catalyst for sustainable photocatalytic H2O2 generation}, volume = {64}, year = {2025}, }
• (2025). Rapid methylation of aryl bromides using air-stable DABCO-Bis(Trimethylaluminum) via nickel metallaphotoredox catalysis. ANGEW, 64(33), e202508710. (www)

  @article{ , abstract = {We report a metallaphotocatalytic strategy for the selective methylation of (hetero)aryl bromides via nickel-catalyzed cross-coupling with bis(trimethylaluminum)-1,4-diazabicyclo[2.2.2]octane (DABAl-Me₃), as a commercially available, air-stable, and non-pyrophoric aluminum-based reagent. The method enables a fast, robust, and scalable methylation protocol that broadly accommodates various functional groups while preventing protodehalogenation. Mechanistic studies confirm the unprecedented generation of methyl radicals from an organo-aluminum precursor under photoredox conditions, bypassing the limitations of conventional two-electron pathways. This work expands the toolbox of practical radical precursors and provides a streamlined approach for selective C(sp 2 )─CH 3 bond formation.}, archive = {J_ANGEW}, author = {Jonas Djossou and Andrea Aloia and Luca Capaldo and Demi D. Snabilié and Morgan Regnier and Jasper H.A. Schuurmans and Antonio Monopoli and Bas de Bruin and Timothy Noël}, doi = {10.1002/anie.202508710}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508710}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid methylation of aryl bromides using air-stable DABCO-Bis(Trimethylaluminum) via nickel metallaphotoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Chelation-driven electrolyte design for enhanced interface and electrochemical window in aqueous aluminum batteries. ANGEW, 64(33), e202508641. (www)

  @article{ , abstract = {Aqueous aluminum-ion batteries have garnered significant attention owing to the abundance of aluminum resources, high theoretical specific capacity, and excellent safety. However, challenges such as electrolyte-induced water decomposition, aluminum anode corrosion, and electrode material compatibility continue to constrain their performance. In this study, we restructured the solvation environment using the chelating reagent Bis(2-methoxyethyl)amine (BMEA), achieving an expanded electrochemical window of 2.2 V and mitigating hydrogen evolution side reactions. Advanced atom probe tomography analysis confirmed that BMEA actively participates in the formation of the solid-electrolyte interphase (SEI), effectively preventing aluminum surface corrosion and extending the cycle life of the aluminum anode. Employed as a BMEA-containing electrolyte in aluminum–organic batteries, the resulting Al||Tetrachloro-1,4-benzoquinone (TCB) battery delivered a high capacity of 218.0 mAh g −1 and demonstrated stable cycling over 300 cycles. This study highlights the potential of chelating agents as additives in advancing high-performance aluminum batteries.}, archive = {J_ANGEW}, author = {Dan-Yang Wang and Erhai Hu and Gang Wu and Honghan Choo and Carlo Franke and Bei-Er Jia and Jinxuan Song and Afriyanti Sumboja and Ivandini T. Anggraningrum and Anne Zulfia Syahrial and Qiang Zhu and Man-Fai Ng and Tong Li and Qingyu Yan}, doi = {10.1002/anie.202508641}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chelation-driven electrolyte design for enhanced interface and electrochemical window in aqueous aluminum batteries}, volume = {64}, year = {2025}, }
• (2025). Laser-induced nanoscale engineering of iridium-based nanoparticles for high-performance oxygen evolution. ANGEW, 64(33), e202508589. (www)

  @article{ , abstract = {While ruthenium oxide exhibits higher activity, it suffers from significantly lower stability in the acidic oxygen evolution reaction (OER). In contrast, crystalline iridium oxide is among the few materials that remain stable under such harsh conditions. However, its low activity and iridium scarcity require strategies to enhance atomic utilization. Conventional high-temperature post-synthetic processing increases the share of rutile-phase iridium oxide while promoting particle growth, reducing catalytic activity due to a diminished surface area. Here, we present a laser-induced nano-oven method using a silicon dioxide matrix as a nanoscale reaction chamber, enabling solid-state nanoparticle synthesis under ambient conditions while preventing agglomeration and allowing precise size control. The synthesized ultra-small crystalline rutile iridium oxide of ∼2 nm achieves a high mass activity of 350 ± 15 A g Ir −1 at 300 mV overpotential, exceeding that of crystalline RuO₂ and reaching the activity benchmark of RuO 2 -based catalysts. Analysis using a channel flow cell with on-line inductively coupled plasma mass spectrometry (ICP-MS) confirms that laser-engineered iridium oxide exhibits superior stability to commercial iridium oxide. Operando electron impact MS provided the synthesis mechanistic insights, demonstrating the potential of this strategy for synthesizing ultra-small crystalline metals and metal oxides for various applications.}, archive = {J_ANGEW}, author = {Huize Wang and Philipp Pfeifer and Wenwei Lai and Andreas Göpfert and Sumin Lim and Wei Zhao and A. Lucía Morales and Mattis Goßler and Marko Malinovic and Pallabi Bhuyan and Walter A. Parada and Pavlo Nikolaienko and Karl J. J. Mayrhofer and Guilherme V. Fortunato and Andreas Hutzler and Marc Ledendecker}, doi = {10.1002/anie.202508589}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Laser-induced nanoscale engineering of iridium-based nanoparticles for high-performance oxygen evolution}, volume = {64}, year = {2025}, }
• (2025). Fortification of FeS clusters reshapes anaerobic CO dehydrogenase into an air-viable enzyme through multilayered sealing of o2 tunnels. ANGEW, 64(33), e202508565. (www)

  @article{ , abstract = {The inherent O 2 sensitivity of Ni─Fe carbon monoxide dehydrogenases (CODHs), crucial for rapid CO to CO 2 interconversion, presents substantial challenges for industrial application. Transforming CO/CO 2 , a prevalent anthropogenic air pollutant, into valuable carbon chemicals either directly or through intermediate steps via biocatalytic methods offers a promising pathway to achieve net-zero emissions across industries and the environment. However, completely eliminating oxygen from industrial biotransformations, especially under ambient conditions, is exceedingly onerous. Here, we engineered variants of the CODH2 from Carboxydothermus hydrogenoformans ( Ch CODH2) with dual blocking at both the O 2 entrance and near the active site, effectively sealing the tunnel against atmospheric O 2 levels (20%). The O 2 -tunnel engineered A559W/V610H variant demonstrated a marked improvement in air stability, with a half-life of 24.6 h compared to the wild type's 2.4 h. Crystallographic snapshots of this air-viable variant after 24 h of exposure revealed the robust integrity of the fortified FeS and NiFeS clusters. Additionally, electro-enzymatic reactions corroborated its CO/CO 2 conversion capability even in ubiquitous air. These findings, which address the O 2 sensitivity of anaerobic enzymes caused by O 2 -induced metal cluster collapse, enhance their potential for biological CO/CO 2 transformations in O 2 -rich environments, thereby broadening their industrial viability and applicability.}, archive = {J_ANGEW}, author = {Suk Min Kim and So Yeon Kong and Jingu Kang and Jeong Seok Ji and Sung Heuck Kang and Hye-Jin Yoon and Hyunwoo Kim and Jungki Ryu and Hyung Ho Lee and Yong Hwan Kim}, doi = {10.1002/anie.202508565}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508565}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fortification of FeS clusters reshapes anaerobic CO dehydrogenase into an air-viable enzyme through multilayered sealing of o2 tunnels}, volume = {64}, year = {2025}, }
• (2025). [TeSeS2]2−: The first heterotriple-chalcogenide motifs decode giant mid-far infrared birefringence. ANGEW, 64(33), e202508555. (www)

  @article{ , abstract = {Optical anisotropy, a cornerstone of polarization control, presents fundamental challenge in functional optical material design due to the intricate interplay between its regulation mechanisms and performance optimization. The development of mid-far infrared (MFIR) birefringent crystals has long been shackled by the incompatibility between giant optical anisotropy and ultrabroad transparency in conventional chalcogenides. Here, we break this shackle via heterotriple-chalcogenide engineering in the first thiotellurite birefringent family, BaTeQ 3 (Q = S, Se), featuring isolated [TeQ 3 ] 2 ⁻ motifs. BaTeS 3 achieves a large experimental birefringence (Δ n = 0.193@550 nm, 15× commercial MgF 2 ). More strikingly, the assembly of three distinct Group VIA chalcogens (S, Se, Te) creates the first heterotriple-chalcogenide motif—[TeSeS 2 ] 2 ⁻ in BaTeSeS 2 , delivering giant Δ n = 0.55@550 nm—a 284% increase from BaTeS 3 and surpassing all commercial benchmarks. BaTeSeS 2 concurrently exhibit ultrabroad transparency (0.5–25 µm), overcoming the classical trade-off between anisotropy and transparency. First-principles calculations reveal that their extraordinary optical anisotropy stems from synergistic stereochemically active lone pair (SCALP)-driven electron localization in [TeQ 3 ] 2− units (electron localization function > 0.8) and Se-induced pyramidal distortion. The pioneering [TeSeS₂] 2 ⁻ heterotriple-chalcogenide motif establishes a transformative design paradigm, which not only redefines the materials motifs for giant MFIR birefringence but also unlocks unprecedented opportunities in next-generation infrared lasers, polarizers, and quantum communication devices.}, archive = {J_ANGEW}, author = {Bo Zhang and Wei-Qi Huang and Jia-Xiang Zhang and Xin-Tao Wu and Hua Lin and Qi-Long Zhu}, doi = {10.1002/anie.202508555}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508555}, shortjournal = {Angew. Chem. Int. Edit.}, title = {[TeSeS2]2−: The first heterotriple-chalcogenide motifs decode giant mid-far infrared birefringence}, volume = {64}, year = {2025}, }
• (2025). An atomically dispersed photocatalyst for undirected para-selective C─H bond functionalizations. ANGEW, 64(33), e202508512. (www)

  @article{ , abstract = {Regioselective C─H bond functionalization is pivotal in modern scientific exploration, offering solutions for achieving novel synthetic methodologies and pharmaceutical development. In this aspect, achieving exceptional regioselective functionalization, like para -selective products in electron-poor aromatics, diverges from traditional methods. Leveraging the advantages of atomically dispersed photocatalysts, we designed a robust photocatalyst for an unconventional regioselective aromatic C─H bond functionalization. This innovation enabled para -selective trifluoromethylations of electron-deficient metadirecting aromatics (─NO 2 , ─CF 3 , ─CN, etc.), which is entirely orthogonal to the traditional approaches. Mechanistic experiments and DFT analysis confirmed the interaction between Cu-atom and the aromatic substrate, alongside the photocatalyst's molecular arrangement, driving selective exposure of the para -selective functionalization. This strategic approach elucidated pathways for precise molecular transformations, advancing the frontier of regioselective C─H bond functionalization by using atomically dispersed photocatalysts in organic synthesis.}, archive = {J_ANGEW}, author = {Suman Pradhan and Jun Hu and Peng Ren and Yuman Qin and Noopur Jain and Susanna Monti and Giovanni Barcaro and Aleksander Jaworski and Xingchao Dai and Jabor Rabeah and Joaquin Silvestre-Albero and Veronica Celorrio and Anna Rokicińska and Piotr Kuśtrowski and Sandra Van Aert and Sara Bals and Shoubhik Das}, doi = {10.1002/anie.202508512}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508512}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An atomically dispersed photocatalyst for undirected para-selective C─H bond functionalizations}, volume = {64}, year = {2025}, }
• (2025). Conformational engineering of solvent molecules for high-voltage and fast-charging lithium metal batteries. ANGEW, 64(33), e202508486. (www)

  @article{ , abstract = {High-voltage and fast-charging lithium metal batteries (LMBs) are crucial for overcoming electric vehicle range and charging limitations. However, conventional carbonate electrolytes face intrinsic limitations in simultaneously achieving compatibility with high-voltage cathodes and lithium metal anodes. These limitations arise from sluggish Li + transport kinetics and parasitic side reactions, both largely driven by excessive Li + solvation energy inherent to carbonates. To address these challenges, we propose a conformational engineering strategy of fluorinated solvent molecules by developing a 2,2,3,3,4,4-hexafluoropentanedioic·anhydride (HFPA)-derived electrolyte (HFPE). The chair conformation of HFPA synergizes with its high F/C ratio to establish a low-polarity solvation environment, effectively reducing desolvation energy barriers. In addition, the HFPA-induced ligand preference for anion aggregation contributes to the formation of anion-rich dissolved sheaths while stabilizing the electrode–electrolyte interphases. The engineered HFPE demonstrates accelerated interfacial ion transport kinetics with an enhanced Li + transference number of 0.64. When paired with LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathodes under stringent operating conditions (4.5 V cut-off voltage, 10 C-rate), HFPE-enabled cells exhibit exceptional cycling stability. Notably, industrial-scale 5.6 Ah lithium metal pouch cells employing HFPE maintain stable operation at 4.5 V, underscoring the practical viability of this conformation modulation approach. This work establishes a paradigm-shifting strategy for next-generation electrolyte design in practical high-energy-density LMBs.}, archive = {J_ANGEW}, author = {Borui Yang and Yuankun Wang and Ruixin Zheng and Wei Yang and Yuanjian Li and Ting Li and Kun Li and Anjun Hu and Jianping Long and Shujiang Ding}, doi = {10.1002/anie.202508486}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508486}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformational engineering of solvent molecules for high-voltage and fast-charging lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Solvent-mediated charge transfer regulation of inner core clusters in hybrid Copper(I)-based halides for high-efficiency X-ray scintillation. ANGEW, 64(33), e202508444. (www)

  @article{ , abstract = {Cu(I)-based metal halides have gained significant interest as scintillators. However, their X-ray luminescence efficiency is mainly determined by the competition between radiative organic ligands and nonradiative metal cluster-centered charge transfer. How to regulate their charge transfer to enhance radiative emission is an intractable challenge. Here, guided by coordination dynamics, we present a solvent mediation strategy to modulate coordination environments and intramolecular charge transfer of organic cuprous halides to achieve vibrant emissions. Mechanistic studies reveal that the coordinated clusters can efficiently absorb radiation ionization to generate electron-hole pairs and transfer them to ligands for enhanced luminescence. Conversely, ligand-free structures exhibit an absence of organic-ligand-related excited states upon excitation, leading to luminescence quenching. Due to optimized metal-to-ligand charge transfer (MLCT) dynamics, a five times enhancement of emission efficiency was achieved with a peak photoluminescence quantum yield (PLQY) of 82.14%. Correspondingly, radioluminescence (RL) was significantly improved to 2.22 and 10 times greater than that of (Lu,Y) 2 SiO 5 :Ce (LYSO) and C 6 H 18 N 2 Cu 2 Br 4 with a high light yield of 73881 photons/MeV (C 12 H 28 N 4 Cu 2 I 2 ) and excellent photochemical stability. A high X-ray imaging resolution of 9.7 lp mm −1 was also demonstrated by the soft C 12 H 28 N 4 Cu 2 I 2 screen even with the thickness of 30 µm. Our study provides a solvent-mediated ligand engineering of copper halide cluster scintillators.}, archive = {J_ANGEW}, author = {Wupei Dong and Fan Yang and Siyuan Zhang and Xizheng Wang and Ming Zhou and Huifang Li and Dianxing Ju}, doi = {10.1002/anie.202508444}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-mediated charge transfer regulation of inner core clusters in hybrid Copper(I)-based halides for high-efficiency X-ray scintillation}, volume = {64}, year = {2025}, }
• (2025). High-rate CO2-to-CH4 photoreduction by dual-proton hydrogenation pathway over pd-anchored oxygen-deficient ZnO nanosheets. ANGEW, 64(33), e202508259. (www)

  @article{ , abstract = {Photoreduction of CO 2 into CH 4 usually comprises upto eight proton-coupled electron transfer steps, greatly reducing the conversion performance. Here, we report a new dual-proton hydrogenation pathway for CO 2 -to-CH 4 conversion, which can condense every two proton-coupled electron transfer steps into one single step. Also, we pioneer the use of in situ synchrotron-radiation vacuum ultraviolet photoionization mass spectrometry to distinguish the crucial HCOOH from COOH intermediates, overcoming the limitation of in situ Fourier-transform infrared spectroscopy. Taking the synthetic Pd/ZnO- V O nanosheets as an example, synchrotron-radiation X-ray absorption fine structure spectroscopy discloses the Pd nanoclusters are anchored on the ZnO- V O nanosheets via building Pd─O bonds, while theoretical calculation demonstrates charge accumulation on the interfacial Pd sites. In situ spectroscopic characterizations, labelling experiments, and adsorption energy calculations collectively establish CO 2 undergoes stepwise dual-proton hydrogenation routes, gradually transforming into *HCOOH, *HCHO, *CH 3 OH, and CH 4 , different from the traditional CO 2 -COOH-CH 4 processes. Thus, the Pd/ZnO- V O nanosheets exhibit superior CH 4 evolution rate of 257.6 µmol g −1 h −1 , outperforming all previously reported photocatalysts. This work unlocks an efficient CO 2 -to-CH 4 pathway, largely reducing the number of reaction steps.}, archive = {J_ANGEW}, author = {Kai Zheng and Siying Liu and Juncheng Zhu and Zhongqin Dai and Chengyuan Liu and Bangwang Li and Youbin Zheng and Xinying Chen and Li Zhai and Yang Wu and Wenxiu Liu and Minghui Fan and Jun Hu and Yang Pan and Junfa Zhu and Fanfei Sun and Yongfu Sun and Yi Xie}, doi = {10.1002/anie.202508259}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-rate CO2-to-CH4 photoreduction by dual-proton hydrogenation pathway over pd-anchored oxygen-deficient ZnO nanosheets}, volume = {64}, year = {2025}, }
• (2025). Strategic secondary coordination implantation towards efficient and stable Fe─N─C electrocatalysts for the oxygen reduction reaction in PEMFCs. ANGEW, 64(33), e202508141. (www)

  @article{ , abstract = {While state-of-the-art Fe─N─C catalysts demonstrate platinum-comparable initial activity for the oxygen reduction reaction (ORR), their operational durability in proton exchange membrane fuel cells (PEMFCs) remains fundamentally limited by progressive destabilization of Fe─N bond under electrochemical cycling, resulting in irreversible metal leaching, catastrophic catalyst degradation and the so-called activity-stability trade-off. Herein, guided by first-principles screening, we demonstrate that the strategic implantation of transition metal ions with d -orbital characteristics analogous to the active site into the secondary coordination sphere, functioning as non-catalytic stabilizers, enables dynamic neutralization of reaction intermediates-induced electronic polarization, thereby achieving stabilization of metal─nitrogen bonds during the ORR cycle. As a proof-of-concept, the integration of isovalent Ru ions as electron-buffing site in the designed FeRu dual-atom catalyst not only achieves a high peak power density of 1.73 W cm −2 with a current density of 58 mA cm −2 at 0.9 V, but also exhibits exceptional durability, with a current decay rate of just 0.2 mA cm −2 h −1 and over 97% Fe retention after prolonged stability tests. This stands in stark contrast to Fe─N─C counterparts, which retain less than 11% of Fe sites under identical conditions.}, archive = {J_ANGEW}, author = {Haifeng Yu and CongCong Li and Yiyang Lei and Zhonghua Xiang}, doi = {10.1002/anie.202508141}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strategic secondary coordination implantation towards efficient and stable Fe─N─C electrocatalysts for the oxygen reduction reaction in PEMFCs}, volume = {64}, year = {2025}, }
• (2025). Overcoming photochemical limitations in covalent organic frameworks: Low-energy light driven selective 1O2 generation achieved by Donor–Acceptor strategy. ANGEW, 64(33), e202508078. (www)

  @article{ , abstract = {Singlet oxygen ( 1 O 2 ) plays a crucial role in various photocatalytic oxidation reactions; however, achieving high-efficiency and selective 1 O 2 production under low-energy light remains a challenge. Herein, we present a novel donor–acceptor (D–A) strategy in covalent organic frameworks (COFs) to regulate the localized electronic state structures for efficient and selective 1 O 2 generation under low-energy light. Notably, the rationally incorporation of the negatively charged carbonyl groups into the basal plane of the COF strengthens the D–A interaction, improves light harvesting in the lower-energy region, and facilitates highly selective 1 O 2 generation through a coupled charge-transfer mechanism. As a result, the engineered COF demonstrates exceptional photocatalytic performance in 1 O 2 driven advanced oxidation, enabling gram-scale production under red light, even when operating through translucent barriers. A mechanistic study revealed that the distinct 1 O 2 production under low-energy light is attributed to the spatially locked structure and charge localization around active centers. These features enhance strong π–π stacking interaction, promote effective charge separation and transport properties, and ultimately facilitate the activation of O 2 to 1 O 2 . This study paves the way for the development of high-performance COF photocatalysts for low-energy light-driven reactive oxygen species generation in advanced oxidation processes.}, archive = {J_ANGEW}, author = {Jikuan Qiu and Hanping Zhai and Yuling Zhao and Yucheng Jin and Zhiyong Li and Huiyong Wang and Zhongping Li and Jianji Wang and Jong-Beom Baek}, doi = {10.1002/anie.202508078}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508078}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Overcoming photochemical limitations in covalent organic frameworks: Low-energy light driven selective 1O2 generation achieved by Donor–Acceptor strategy}, volume = {64}, year = {2025}, }
• (2025). Si─O molecular engineering enhances cathode-anode interface stability for high-loading and high-voltage layered cathode-lithium metal batteries. ANGEW, 64(33), e202508008. (www)

  @article{ , abstract = {Nickel-rich layered cathodes and lithium metal anode are promising for the next generation high-energy-density batteries. However, the unstable electrode-electrolyte interface induces structural degradation and battery failure under high-voltage and high-loading conditions. Herein, we report a fluorosilane-coupled electrolyte stabilizer with 1H, 1H, 2H, 2H-perfluorooctyltrimethoxysilane (PFOTMS), which presents higher adsorption energy with LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode than solvents through the conjugation of Si─O bonds and therefore is oxidized on its surface to derive an interfacial layer rich in F and Si─O species. This architecture effectively stabilizes the cathode structure, suppresses transition metal migration, and promotes Li + conduction and uniform deposition, which also suppresses the side reactions of electrolyte with both cathode and anode. This unique interfacial stabilization mechanism enables the Li||NCM811 battery to achieve a capacity retention rate of 80.8% after 600 cycles at 4.7 V. The Li||LiCoO 2 cell with a high mass loading of 20 mg cm −2 achieves a remarkably high-capacity retention of 92.79% after 500 cycles at 4.4 V. This work proposes an interfacial stabilization that overcomes high-voltage limitations in practical nickel-rich cathode/lithium metal batteries.}, archive = {J_ANGEW}, author = {Shangjuan Yang and Zhoujie Lao and Zhuo Han and Hai Su and Guanyou Xiao and Guangmin Zhou and Danfeng Zhang and Yan-Bing He}, doi = {10.1002/anie.202508008}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202508008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Si─O molecular engineering enhances cathode-anode interface stability for high-loading and high-voltage layered cathode-lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Twisting chiral aggregation-induced emission macrocycles into a microhelix with boosted circularly polarized luminescence. ANGEW, 64(33), e202507992. (www)

  @article{ , abstract = {The design and assembly of chiral macrocycles remain an underexplored frontier in supramolecular science. In this study, we synthesized a pair of enantiomeric macrocyclic molecules (CP1) through the condensation of chiral cyclohexanediamine with tetraphenylethylene (TPE) dialdehyde. These molecules exhibited remarkable circular dichroism (CD) and circularly polarized luminescence (CPL) properties at the supramolecular level. Through supramolecular assembly in mixed solvent systems, we achieved a rare micron-scale helical structure, exhibiting a high luminescence dissymmetry factor ( g lum ) of 0.32—one of the highest values reported to date for macrocyclic self-assemblies. Furthermore, by designing a chiral macrocycle with phenyl spacers (CP2), we revealed that the confinement of macrocycles and restricted internal molecular rotation are critical for achieving high g lum values and helical structure formation. This work not only advances the design of chiral macrocycles but also provides new insights into the relationship between molecular structure and supramolecular assembly, paving the way for the development of advanced chiral materials with potential applications in optics, sensing, and nanotechnology.}, archive = {J_ANGEW}, author = {Sipeng Wang and Shengfu Wu and Runjia Wang and Jie Lu and Minghua Liu}, doi = {10.1002/anie.202507992}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507992}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Twisting chiral aggregation-induced emission macrocycles into a microhelix with boosted circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Enhancing clinical detection accuracy of large structured viral RNA via DNAzyme cleavage and antisense-assisted rolling circle amplification. ANGEW, 64(33), e202507973. (www)

  @article{ , abstract = {Sensitive detection of viral RNA is critical for accurate diagnostic testing, particularly during outbreaks of emerging infectious diseases. Rolling circle amplification (RCA) is a powerful isothermal amplification strategy that can be directly primed by RNA, eliminating the need for reverse transcription. Previous approaches have used 10–23 DNAzymes to cleave viral RNA, generating 3′-ends for hybridization to circular DNA templates (CDTs). However, the resulting RNA fragments often retained secondary or tertiary structures that hindered CDT binding and limited RCA efficiency. To address this challenge, we developed antisense oligonucleotide-assisted RCA (ASO-RCA), a general strategy that uses short upstream antisense oligonucleotides (ASOs) to remodel RNA structure and expose the CDT-binding site. Using five DNAzyme-CDT systems targeting distinct regions of the SARS-CoV-2 genome, we show that ASO inclusion improves CDT hybridization and enhances RCA output—by up to 70-fold. This enhancement was observed using both linear and quasi-exponential RCA formats and remained effective in 50% pooled saliva. When applied to clinical saliva samples, ASO-assisted RCA markedly improved diagnostic performance, achieving 100% sensitivity and up to 97.5%–100% accuracy across multiple systems. These findings establish ASO-DNAzyme-RCA as a simple, robust, and clinically relevant platform for improving nucleic acid detection in structured RNA targets.}, archive = {J_ANGEW}, author = {Amal Mathai and Jimmy Gu and Connor Nurmi and John D. Brennan and Yingfu Li}, doi = {10.1002/anie.202507973}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing clinical detection accuracy of large structured viral RNA via DNAzyme cleavage and antisense-assisted rolling circle amplification}, volume = {64}, year = {2025}, }
• (2025). Buried interface modification strategy for efficient tin-based perovskite light-emitting diodes. ANGEW, 64(33), e202507914. (www)

  @article{ , abstract = {Tin (Sn)-based perovskites show great potential for environmentally friendly and high-performance light-emitting diodes (LEDs). However, the development of Sn-based perovskite LEDs (PeLEDs) lags significantly behind that of lead-based perovskites. This is mainly due to the faster crystallization rate of Sn-based perovskites that leads to a higher defect density in Sn-based perovskite films, thereby serious nonradiative recombination. Here, we demonstrated a buried interface modification (BIM) strategy to regulate the crystallization kinetics of Sn-based perovskite films by using carboxylate as multifunctional surface modifiers. We reveal that the buried interface is critical to improve the nucleation and crystallization of Sn-based perovskite films. As a result, efficient near-infrared Sn-based PeLEDs were achieved with an external quantum efficiency (EQE) of 11.9%. This work suggests an efficient and elegant route to obtain high-performance Sn-based perovskite films and devices.}, archive = {J_ANGEW}, author = {Zheng Jiang and Jie Yang and Wenbin Wang and Yangyu Liu and Yuhan Zhou and Jing Xu and Wang Wang and Hongyao Ding and Ya Zhong and Haifeng Zhao and Sai Bai and Weidong Xu and Wing Chung Tsoi and Tao Yu and Chunxiong Bao and Xiaodong Shen and Pengpeng Teng}, doi = {10.1002/anie.202507914}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507914}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Buried interface modification strategy for efficient tin-based perovskite light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Unraveling the impact of organic cation dipole moment on rashba spin-splitting in 2D hybrid Organic–Inorganic perovskites. ANGEW, 64(33), e202507829. (www)

  @article{ , abstract = {Rashba spin-splitting in hybrid organic–inorganic perovskites (HOIPs) holds great potential for spintronic applications. However, strategies for controlling Rashba spin-splitting in these materials remain underexplored. Here, we find organic cation dipole moments play a pivotal role in modulating Rashba effects. By comparing p -FPEA 2 PbI 4 and PEA 2 PbI 4 , we demonstrate that larger dipole moments amplify lattice distortion and local symmetry breaking, as confirmed by second-harmonic generation (SHG). This structural asymmetry doubles the Rashba spin-splitting energy, quantified through the circular photogalvanic effect (CPGE) and circularly polarized light excited photoluminescence (CPLEPL). Circular dichroism (CD) and magnetic circular dichroism (MCD) reveal a Rashba-induced effective magnetic field, while spin pumping shows a ∼50% higher Rashba coefficient in p -FPEA 2 PbI 4 . These results establish a direct correlation between dipole moment and spin splitting in 2D HOIPs, a trend that extends to quasi-2D and 3D HOIPs. Our work shows dipole engineering as a general design rule for tailoring Rashba effects in HOIPs, paving the way toward high-efficiency spin-based optoelectronics and quantum devices.}, archive = {J_ANGEW}, author = {Lvpeng Yang and Yerun Gao and Yufei Zhai and Ming Shao}, doi = {10.1002/anie.202507829}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507829}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the impact of organic cation dipole moment on rashba spin-splitting in 2D hybrid Organic–Inorganic perovskites}, volume = {64}, year = {2025}, }
• (2025). Two-step crystal dissolution: A molecular mechanism to rationalize empiric models of drug release from API formulations for oral administration. ANGEW, 64(33), e202507827. (www)

  @article{ , abstract = {The kinetics of drug release from molecular crystals is commonly described by the Nernst-Brunner model created in 1904 – and since then, numerous empirical evidence supporting its suitability as a mathematical approximation has been collected. However, providing mechanistic rationales turned out to be much more complicated. Elaborating on the molecular mechanisms of acid-induced carbamazepine (CBZ) dissolution, we suggest a molecular simulation case study of “Nernst-Brunner type” drug release to an aqueous solution featuring an interfacial “diffusion” layer. Mimicking pH = 2, we find drastic protonation of the drug crystallite model, followed by the dissolution of both single CBZH + solutes and fragments of the crystal edges. The latter lead to the release of [CBZH n ] n+ aggregates (with n = 2–8) into the solution, thus fueling a dynamic interplay of different solute species. In some analogy to so-called two-step crystal nucleation, we therefore suggest a two-step crystal dissolution mechanism encompassing solute aggregates within a “dense-solutes domain”. Within an interfacial region between the crystal and the bulk solvent, such aggregates are suggested as “puffer species” that account for a constant concentration of the fully solvated solute species.}, archive = {J_ANGEW}, author = {Moritz Macht and Dirk Zahn}, doi = {10.1002/anie.202507827}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507827}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-step crystal dissolution: A molecular mechanism to rationalize empiric models of drug release from API formulations for oral administration}, volume = {64}, year = {2025}, }
• (2025). Constructing supported metallic pt single atoms in molten NaAlCl4. ANGEW, 64(33), e202507803. (www)

  @article{ , abstract = {Supported platinum-group-metal single-atom catalysts (SACs) have garnered widespread attention in heterogeneous catalysis due to their theoretical 100% atomic utilization efficiency. Isolated metal atoms usually exhibit high oxidation states rather than metallic states owing to the coordination with nonmetal atoms in the supports. Despite recent advances in modulating the coordination environments of SACs, achieving metallic state-dominated SACs remains a formidable challenge. Herein, a new configuration of metallic Pt single atoms (Pt 0 ) anchored on the CeO 2 support is constructed by introducing a localized Pt–Ce metal–metal coordination at the interface in a molten NaAlCl 4 environment. The extensive Pt─Ce bonding and electron transfer from the support to the Pt atoms ensure the metallic nature of isolated Pt atoms. This work opens up a new avenue for constructing metallic single atoms and enriches the SACs chemistry.}, archive = {J_ANGEW}, author = {Wei Guo and Han Su and Qingyu Wang and Mingxia Gao and Xusheng Zheng and Hongge Pan and Wenping Sun}, doi = {10.1002/anie.202507803}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507803}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing supported metallic pt single atoms in molten NaAlCl4}, volume = {64}, year = {2025}, }
• (2025). Nature of anti-dissipative high-energy excited states in quaterpyridine-bridged ruthenium complexes. ANGEW, 64(33), e202507738. (www)

  @article{ , abstract = {High-energy excited states with slow rates for internal conversion to the lowest-energy excited state are prone to be intercepted before they dissipate energy to the medium. In a previous report, oligomeric Ru(II) photosensitizers bearing a bridging 2,2′:5′,3″:6″,2 ‴ –quaterpyridine scaffold showed promising anti-dissipative behavior in photoinduced electron transfer reactivity. In here, a range of electron accepting and electron donating substituents were incorporated on the ancillary 2,2′-bipyridine ligands to modulate the excited-state dynamics. This allowed to unambiguously identify the nature of high-energy excited states and derive design guidelines for the achievement of anti-dissipative behavior in oligomeric Ru(II) polypyridines relevant for solar fuels production and photoredox catalysis.}, archive = {J_ANGEW}, author = {Noémie Chantry and Agustina Cotic and Simon De Kreijger and Riccardo Di Forti and Benjamin Elias and Ludovic Troian-Gautier and Alejandro Cadranel}, doi = {10.1002/anie.202507738}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507738}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nature of anti-dissipative high-energy excited states in quaterpyridine-bridged ruthenium complexes}, volume = {64}, year = {2025}, }
• (2025). Effect of ambient organic acids on the water structure at TiO2 interfaces. ANGEW, 64(33), e202507721. (www)

  @article{ , abstract = {A molecular-level understanding of the effects of ambient organic compounds on the wettability of titanium dioxide ( ) surfaces is relevant to many of its energy-related and environmental applications. Herein, we focus on two common atmospheric carboxylic acids, formic and acetic acid, and characterize their adsorption/ desorption at the aqueous interfaces of anatase and rutile using molecular dynamics with an ab initio deep neural network potential. Our simulations show that these acids prefer to be localized in the interfacial water layers close to the surface where they are stabilized by the interaction/exchange of their acid proton with a surface oxygen, rather than chemisorb at the surface Ti sites by displacing the adsorbed water. Notably, these acids make the surface of anatase hydrophobic, whereas the larger fraction of adsorbed water dissociation can offset their effect on rutile. These results provide a picture where carboxylic acids control the wettability of largely through acid-base chemistry at the interface rather than chemisorption on the oxide surface, a finding that can help improve the design of self-cleaning surfaces and photocatalytic devices.}, archive = {J_ANGEW}, author = {Abhinav S. Raman and Annabella Selloni}, doi = {10.1002/anie.202507721}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507721}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Effect of ambient organic acids on the water structure at TiO2 interfaces}, volume = {64}, year = {2025}, }
• (2025). Visible-light-driven selective mineralization of organohalides on spatially close au single-atom and nanocluster neighbors over Poly(Heptazine imides). ANGEW, 64(33), e202507654. (www)

  @article{ , abstract = {Organohalides are commonly found pollutants with long-term persistence in industrial wastewater and drinkable water. Although these pollutants only constitute a small portion of the total organic carbon (TOC), they contribute major toxicity, posing a threat to ecosystem, biodiversity, and public health. Selective removal of organohalides from wastewater/drinkable water is costly due to the orders of magnitude lower concentration of organohalides as compared to interferences. Herein, spatially close Au single atoms and nanoclusters composing of approximately 3–10 Au atoms were grown on highly crystalline potassium-incorporated poly(heptazine imides). Microscopy and spectroscopy characterizations together with theoretical calculations revealed that under visible-light illumination, the highly localized photogenerated holes could enable simultaneous generation of •OH on Au single atoms and selective adsorption of organohalides on Au nanoclusters, which greatly promoted the targeted removal of trace organohalides in water containing high concentrations of interferences. The fixed-bed photoreactor built using the spatially close Au single atoms and nanoclusters on poly(heptazine imides) achieved quick degradation of refractory organohalide pollutants in tap water and ground water (2 L h −1 ), exhibiting an over 3-fold log efficiency enhancement compared to traditional advanced oxidation processes.}, archive = {J_ANGEW}, author = {Zhenyuan Teng and Ying Tu and Nan Jian and Qitao Zhang and Ying-Rui Lu and Laiquan Li and Zhijun Cao and Yanhui Ao and Mingkai Liu and Yan Yan and Jing Wang and Huan Wu and Teruhsia Ohno and Jianmei Lu and Chenliang Su and Bin Liu}, doi = {10.1002/anie.202507654}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-light-driven selective mineralization of organohalides on spatially close au single-atom and nanocluster neighbors over Poly(Heptazine imides)}, volume = {64}, year = {2025}, }
• (2025). Interplay between stereochemically active lone pair repulsions, sigma hole interactions, and delocalized redox processes in topochemical fluoride-ion insertion. ANGEW, 64(33), e202507650. (www)

  @article{ , abstract = {Topochemical insertion/extraction of cations has emerged as a generalizable strategy for modulating the crystal and electronic structure of periodic solids. In contrast, strategies for topochemical anion insertion are poorly explored and fundamental principles for designing insertion hosts to accommodate anions remain scarce. Here, we observe reversible room-temperature fluoride-ion insertion within tunnels of Sn 2 TiO 4 defined by the stereochemical expression of Sn 5 s 2 lone pairs. X-ray scattering studies of fluoride-ion-insertion-induced crystal structure modulation and X-ray absorption/emission spectroscopy probes of electronic structure along with magnetic susceptibility measurements and first-principles calculations are used to decipher design principles underpinning reversible fluoride-ion insertion and bulk diffusion. Fluoride-ion insertion is enabled by a combination of a large, polarizable tunnel, delocalized redox at Ti─O─Sn centers, inherent repulsion between the fluoride-ion and Sn 5 s 2 electron lone pairs, and the formation of dative interactions between Sn-centered σ-holes and fluoride-ions, yielding a reversible capacity of 0.5 fluoride-ions per Sn 2 TiO 4 formula unit. Our results demonstrate that the complex interplay between dative interactions and stereochemically active lone pair repulsions is critical to defining the thermodynamics and kinetics controlling fluoride-ion insertion and diffusion. As such, the design of fluoride-ion insertion hosts for anion batteries requires site-selective modification to modulate lattice—ion interactions.}, archive = {J_ANGEW}, author = {Anindya Pakhira and Shruti Hariyani and George Agbeworvi and Jaime R. Ayala and Conan Weiland and Cherno Jaye and Daniel A. Fischer and Lu Ma and Sarbajit Banerjee}, doi = {10.1002/anie.202507650}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507650}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interplay between stereochemically active lone pair repulsions, sigma hole interactions, and delocalized redox processes in topochemical fluoride-ion insertion}, volume = {64}, year = {2025}, }
• (2025). Catalytic activation of Acceptor–Acceptor bicyclobutanes enabled by lewis base catalysis. ANGEW, 64(33), e202507590. (www)

  @article{ , abstract = {Owing to the advent of various state-of-the-art strategies, the utilization of donor-acceptor bicyclo[1.1.0]butanes (BCBs) as a three-atom component in (3 + X) cycloaddition reactions has emerged as a highly efficient platform for constructing saturated bicyclic scaffolds that can serve as arene bioisosteres. However, the application of Lewis base catalysis in such reactions remains underexplored, and the strategy for the cycloaddition of acceptor–acceptor BCBs remains unknown. Herein, we report the first formal (4 + 2) cycloaddition of acceptor–acceptor BCBs, which serve as a four-atom component, for the selective synthesis of pharmaceutically valuable oxa-bicyclo[3.1.1]heptanes (oxa-BCHeps) enabled by N -heterocyclic carbene (NHC) catalysis. BCBs and carbonyl compounds, such as aldehydes and ketones, with various functional groups, are well-tolerated under mild conditions, yielding oxa-BCHeps with up to 87% yield, competing with at least five side reactions. The versatility of this synthetic method is further demonstrated through derivatization of the (4 + 2) cycloadducts and late-stage functionalization of pharmaceuticals. The reaction mechanism and the origins of the chemoselectivity were investigated by means of density functional theory calculations.}, archive = {J_ANGEW}, author = {Jin-Lan Zhou and Xuan Zhan and Heng-Xian He and Youzhi Xu and Quanxin Peng and Genping Huang and Jian-Jun Feng}, doi = {10.1002/anie.202507590}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507590}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic activation of Acceptor–Acceptor bicyclobutanes enabled by lewis base catalysis}, volume = {64}, year = {2025}, }
• (2025). Stimuli-responsive catenane-branched dendrimers with tunable dimension for reversible guest binding. ANGEW, 64(33), e202507576. (www)

  @article{ , abstract = {To tackle the challenge of the precise construction of catenane-based mechanically interlocked macromolecules with well-defined topological arrangements, starting from a novel [2]catenane building block with dendrimer growth sites, catenane-branched dendrimers have been precisely constructed via an efficient and controllable divergent approach. Notably, to the best of our knowledge, the third-generation dendrimer which consists of twenty-one [2]catenane branches is the most complicated discrete [2]catenane oligomer synthesized to date. Interestingly, the switchable coconformation transformations of [2]catenane branches triggered by sodium ions and cryptands lead to an integrated and amplified expansion–contraction motion of the resultant dendrimers, achieving reversible size regulation at the nanoscale. The unique recognition sites of the resultant catenane-branched dendrimers also facilitate the reversible binding of drug and dye guests. This work not only addresses the synthetic challenge of highly branched catenane dendrimers but also provides a new platform for dynamic supramolecular functional materials.}, archive = {J_ANGEW}, author = {Yu Wang and Zhiwen Gao and Xue Li and Pei-Pei Jia and Xiao-Qin Xu and Yefei Jiang and Xu-Qing Wang and Wei Wang and Hai-Bo Yang}, doi = {10.1002/anie.202507576}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507576}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stimuli-responsive catenane-branched dendrimers with tunable dimension for reversible guest binding}, volume = {64}, year = {2025}, }
• (2025). Non-amphiphilic antimicrobial polymers. ANGEW, 64(33), e202507564. (www)

  @article{ , abstract = {Antimicrobial resistance (AMR) is a severe threat to modern healthcare and must be addressed to prevent millions of deaths in the coming decades. Antimicrobial polymers (APs) do not provoke resistance and are promising alternatives to conventional antibiotics. Classic APs possess an amphiphilic structure (cationic and hydrophobic). Herein, we question the necessity of amphiphilicity in APs and find that hydrophobicity is not an essential quality in these polymers. Combining cationic monomers with hydrophilic subunits containing hydrogen bond donors results in excellent antibacterial activity and concurrently low unspecific toxicity. Non-amphiphilic APs have the unique ability to cluster in isolated membrane regions, creating a supramolecular multivalence that enhances their membrane activity and aggregates bacterial cells. This effect, which only unfolds in the absence of hydrophobicity, opens new possibilities in the design of antimicrobial materials.}, archive = {J_ANGEW}, author = {Alain M. Bapolisi and Anne-Catherine Lehnen and Martin Wolff and Jana Kramer and Sergio Kogikoski and René Steinbrecher and Nicole Michler and Andreas Kiesow and Ilko Bald and Martina Obry and Sebastian Kersting and Till Stensitzki and Henrike M. Müller-Werkmeister and Meike N. Leiske and Salvatore Chiantia and Matthias Hartlieb}, doi = {10.1002/anie.202507564}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507564}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-amphiphilic antimicrobial polymers}, volume = {64}, year = {2025}, }
• (2025). Multipath ROS storm and immune activation via sulfur vacancy-optimized ZnIn2S4 nanosheets for piezocatalytic tumor therapy. ANGEW, 64(33), e202507502. (www)

  @article{ , abstract = {Piezocatalytic therapy is a novel therapeutic strategy that uses mechanical energy to drive catalytic reactions to generate cytotoxic reactive oxygen species (ROS). However, existing materials are limited by low intrinsic catalytic efficiency and a single route to ROS production. This makes it difficult to break through the antioxidant barrier of the tumor microenvironment, which severely limits the antitumor efficacy. Herein, we synthesized sulfur vacancy (S v )-engineered ZnIn 2 S 4 nanosheets (ZIS-2/4/8) by adjusting the concentrations of sulfur source thioacetamide (TAA). The increase in S v concentration simultaneously achieved the optimization of the energy band structure and the enhancement of the piezoelectric performance ( d 33 from 21.6 to 46.7 mV V −1 ). Under US irradiation, S v -ZnIn 2 S 4 can efficiently generate ROS storms via multiple pathways, including •O 2 − , 1 O 2 , •OH, and H 2 O 2 , which overcome the limitations of the tumor microenvironment and achieved effective tumor cell killing. In addition, the ROS storm induced by the ultrasound (US) can also initiate immunogenic cell death (ICD), promoting dendritic cells (DCs) maturation and CD8⁺ T cells infiltration. This multi-pathway ROS burst strategy not only breaks through tumor antioxidant defenses but also induces ICD to form a cascade of immune responses. This demonstrates the advantages of combining piezocatalytic and immunotherapy.}, archive = {J_ANGEW}, author = {Mingkai Yang and Binbin Ding and Xinyu Ma and Jing Li and Di Han and Sainan Liu and Zhendong Liu and Jia Tan and Hao Chen and Pan Zheng and Ping'an Ma and Jun Lin}, doi = {10.1002/anie.202507502}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multipath ROS storm and immune activation via sulfur vacancy-optimized ZnIn2S4 nanosheets for piezocatalytic tumor therapy}, volume = {64}, year = {2025}, }
• (2025). Confinement of polyiodides by dual-functional tetrazine cathodes in Zn–I2 batteries. ANGEW, 64(33), e202507497. (www)

  @article{ , abstract = {Zinc–iodine batteries offer great potential for energy storage due to their long-term cycle stability, flat voltage plateau, inherent safety, and cost-effectiveness. However, their performance is limited by capacity fading and low Coulombic efficiency (CE) caused by the I 3 − shuttle effect. In this work, we propose a molecularly engineered tetrazine derivative, 3,6-bis(2-morpholinoethyl)-1,2,4,5-tetrazine (BMT) as a multifunctional cathode to address these challenges. BMT exhibits a reversible two-electron redox process, boosting charge storage capacity, and forms stable precipitation with I 3 − ions at a 1:2 stoichiometric ratio, effectively inhibiting the shuttle of polyiodide by covalent-electrostatic synergistic confinement. As expected, the BMT-based cathode exhibits a CE of 99.6% at 2 A g −1 , a high specific discharge capacity of 207 mAh g −1 at 0.5 A g −1 as well as ∼100% capacity retention over 33 000 cycles at 2 A g −1 , achieving a record iodine anchoring efficiency. Furthermore, the Zn–I 2 pouch cell with high iodine mass loading (15.5 mg cm −2 ) delivers a practical cathode energy density of 145.2 Wh kg −1 and maintains 76.2% of its capacity after 800 cycles at 2 A g −1 . This work presents a mechanism-driven cathode design strategy that integrates redox activity and polyiodide confinement, providing a blueprint for the development of stable iodine-based batteries.}, archive = {J_ANGEW}, author = {Bei Qi and Yongping Chai and Yajie Hu and Zhengyao Liu and Yan Wang and Kang Chen and Chaoran Tan and Xinyu Bai and Kefeng Xie and Huhu Cheng and Xiaodong Chi and Liang Huang and Liangti Qu}, doi = {10.1002/anie.202507497}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507497}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Confinement of polyiodides by dual-functional tetrazine cathodes in Zn–I2 batteries}, volume = {64}, year = {2025}, }
• (2025). Enhancing acidic oxygen evolution activity by controlling oxidation state of iridium. ANGEW, 64(33), e202507468. (www)

  @article{ , abstract = {Iridium oxides with high oxidation states have been reported to be effective in enhancing the acidic oxygen evolution reaction (OER) performance. Herein, we develop ultrasmall IrO x nanoparticles (NPs) over titanium nitride (TiN), which undergoes surface oxidation under oxidative conditions to form oxygen-modified TiN (oxi-TiN), enabling the formation of highly oxidized Ir δ+ (δ > 4). This IrO x /oxi-TiN catalyst delivers higher Ir mass activity than commercial IrO 2 , while comparable stability is maintained. The superior OER activity of IrO x /oxi-TiN is further demonstrated in a proton exchange membrane water electrolyzer (PEMWE), requiring only 1.88 V to reach 3 A cm −2 , achieving the U.S. Department of Energy 2025 target (1.90 V at 3 A cm −2 ). In situ X-ray absorption spectroscopy (XAS) confirms that the superior OER activity of IrO x /oxi-TiN originates from highly oxidized Ir δ+ under OER conditions. Density functional theory (DFT) calculations reveal a general correlation between the oxidation state of Ir and OER overpotential. Specifically, the introduction of interfacial oxygen at the Ir/TiN interface increases the oxidation state of deposited Ir δ+ from δ < 4 to δ > 4, decreasing the OER overpotential. This study highlights the critical role of high oxidation states of Ir δ+ in enhancing OER activity, providing guidance for the development of advanced acidic OER catalysts.}, archive = {J_ANGEW}, author = {Xue Han and Tianyou Mou and Sinwoo Kang and Arephin Islam and Xueru Zhao and Kotaro Sasaki and José A. Rodriguez and Qiaowan Chang and Ping Liu and Jingguang G. Chen}, doi = {10.1002/anie.202507468}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507468}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing acidic oxygen evolution activity by controlling oxidation state of iridium}, volume = {64}, year = {2025}, }
• (2025). Photothermal CuS as a hole transfer layer on BiVO4 photoanode for efficient solar water oxidation. ANGEW, 64(33), e202507259. (www)

  @article{ , abstract = {Sluggish hole transport kinetics are one of the key limitations of bismuth vanadate (BiVO 4 ) photoanodes in photoelectrochemical (PEC) water splitting, severely impeding the attainment of high solar-to-hydrogen (STH) conversion efficiency. Herein, a copper sulfide (CuS) hole transfer layer (HTL) with photothermal effect is reported to markedly enhance the PEC water splitting via the synergistic action of photothermal effect and hole transfer. This is demonstrated in the BiVO 4 /CuS/NiFeCoO x photoanode, where the CuS layer establishes a transport channel for photogenerated holes, effectively inhibiting charge recombination and trapping. Additionally, the thermal effect induced by localized surface plasmon resonance (LSPR) enhances the water oxidation activity of the surface NiFeCoO x cocatalyst and boosts the charge mobility. The optimized BiVO 4 /CuS/NiFeCoO x photoanode exhibits exceptional performance, achieving a water oxidation photocurrent density of 6.56 mA cm −2 at 1.23 V versus reversible hydrogen electrode (V RHE ) and a STH conversion efficiency of 7.17% when connected in series with Si solar cells. Experimental analyzes and density functional theory (DFT) calculations collectively reveal the pivotal role of CuS HTL in facilitating carrier separation and transport. This work highlights the potential of interfacial engineering to facilitate charge separation and transfer, providing a new strategy for the construction of photoanodes to achieve efficient water splitting.}, archive = {J_ANGEW}, author = {Jingkun Wang and Naik Muhammad and Zijing Chuai and Wenping Xu and Xiujie Tan and Qiqiao Zhou and Yuan Yu and Junjie Guo and Tianbao Li and Bingshe Xu}, doi = {10.1002/anie.202507259}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photothermal CuS as a hole transfer layer on BiVO4 photoanode for efficient solar water oxidation}, volume = {64}, year = {2025}, }
• (2025). Deciphering and predicting thermal and pH stabilities of triplex DNA under multifactorial conditions. ANGEW, 64(33), e202507190. (www)

  @article{ , abstract = {Triplex DNA, a critical noncanonical nucleic acid structure, plays essential roles in gene regulation, disease pathogenesis, and therapeutic targeting. To unravel how environmental and sequence factors modulate triplex stability, we developed a high-throughput 5D fluorescence resonance energy transfer melting annealing (5DFRETMA) method. No less than 414 sets of buffer conditions were tested. Monotonically negative correlations were observed between thermal stability and pH, as well as between pH stability and temperature. These relationships are sequence dependent: triplexes with higher G•C + Hoogsteen base pair content display a higher sensitivity to pH and temperature variations. Ionic strength exerts dual effects: stabilizing the Hoogsteen hydrogen bonds in A•T base pairs while destabilizing them in G•C + base pairs, resulting in a complex ionic strength dependent stability diagram. Critically, as the G•C + content increases, the relationship between triplex stability and ionic strength shifts progressively from a monotonically positive to negative dependence. We developed predictive models that not only predict thermal stability but also pioneer the prediction of pH stability under variable temperatures and ionic environments. This work advances the mechanistic understanding of triplex DNA behavior in biologically complex settings, offering tools for the rational design of gene targeted therapeutics and synthetic biology applications.}, archive = {J_ANGEW}, author = {Shilong Zhang and Jiqing Shen and Ziyue Guan and Tengshuo Luo and Chengjie Chu and Haoyu Zhu and Jean-Louis Mergny and Mingpan Cheng}, doi = {10.1002/anie.202507190}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering and predicting thermal and pH stabilities of triplex DNA under multifactorial conditions}, volume = {64}, year = {2025}, }
• (2025). Strain-induced benzannulation of oxaquadricyclanes promoted by a polyoxometalate photocatalyst. ANGEW, 64(33), e202507189. (www)

  @article{ , abstract = {Given the significance of strain-release reactions, various spring-loaded molecules have emerged as important building blocks in diverse fields of chemical science. Despite progress in this area, oxaquadricyclanes remain an understudied class of molecules. In the present report, the strain energy of in situ generated oxaquadricyclane was utilized for benzannulation reaction, which was photocatalyzed by a polyoxometalate (POM)-based photocatalyst ({Mo₇O 24 @γ-FeO(OH)}), in which the Anderson-type polyoxomolybdate [Mo₇O₂₄]⁶⁻ anions enhance the stability of photoactive γ-FeO(OH) nanocore. The band alignment of this POM-based complete inorganic semiconductor enables the harvesting of photons from visible light and provides superior thermal and oxidative stability while addressing the cost and performance limitations of conventional organo-photocatalysts. Using this novel photocatalyst, we successfully synthesized benzindene and dihydrophenanthrene scaffolds from dienyl sulfoxonium ylides and electron-deficient alkynes through unusual photochemical rearrangements. These benzannulated compounds are notable for their structural similarity to bioactive aromatic steroids and demonstrate their potential as lead candidates for therapeutic development. Through systematic optimization and mechanistic studies, we highlight the critical role of the POM catalyst, the challenges of controlling strain energy-driven reactivity, and the selective rearrangement of oxaquadricyclane scaffolds.}, archive = {J_ANGEW}, author = {Daksh S. Davas and Laxmikanta Mallick and Dinesh K. Gopalakrishnan and Biswarup Chakraborty and Janakiram Vaitla}, doi = {10.1002/anie.202507189}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507189}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strain-induced benzannulation of oxaquadricyclanes promoted by a polyoxometalate photocatalyst}, volume = {64}, year = {2025}, }
• (2025). Selective functionalization of benzene ring via carbene-initiated [4,5]-rearrangement. ANGEW, 64(33), e202507149. (www)

  @article{ , abstract = {The extreme similarity in electronic and steric reactivity among the C─H bonds present on alkyl-substituted aromatic rings presents a formidable challenge when it comes to achieving high selectivity during the para -selective functionalization of these bonds. This article presents a unique study that delves into the para -selective functionalization or dearomatization functionalization of benzene rings, achieved through the reaction of carbenes with allyl sulfoxides. Mechanistic investigations suggest that the transformation likely proceeds via an uncommon carbene-mediated [4,5]-rearrangement process.}, archive = {J_ANGEW}, author = {Xuerong Wang and Chuang Mei and Yulu Song and Fengyi Liu and Hongyan Yang and Yao Lei and Jiarong Shi}, doi = {10.1002/anie.202507149}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507149}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective functionalization of benzene ring via carbene-initiated [4,5]-rearrangement}, volume = {64}, year = {2025}, }
• (2025). ATP-inducible receptor oligomerization enables fine-tuning of t cell immunity. ANGEW, 64(33), e202507125. (www)

  @article{ , abstract = {Receptor oligomerization plays a pivotal role in the regulation of cellular behaviors and functionalities. Stimuli-responsive artificial circuits are often programmed to rewire cell signaling by fine-tuning receptor interactions through targeted stimulation. Notably, the integration of tumor microenvironment (TME)-responsive systems capable of locally altering cancer cell phenotypes or transforming anti-tumor responses of immune cells offers a novel and promising strategy for enhancing the therapeutic effectiveness and safety of cancer treatments. In this paper, we introduce an adenosine triphosphate (ATP)-inducible receptor oligomerization (ATIRO) approach to facilitate the clustering of CD3 and CD8 of T cells and the engagement of CD3 and tumor markers of T cells and targeted cancer cells to prompt anti-tumor immunity. ATIRO enables the specific in situ activation of T cells by the high-level ATP presented in TME, thereby effectively suppressing tumor growth in vivo. ATIRO presents a versatile and readily adaptable strategy for the in-situ reconfiguration of T cell immunity, holding significant potential for advancing cancer therapeutic interventions.}, archive = {J_ANGEW}, author = {Haoxiang Li and Fuling Liang and Xin Yu and Shasha Sun and Hui Li and Mingyan Jiang and Jian-Hui Jiang and Jianjun He}, doi = {10.1002/anie.202507125}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507125}, shortjournal = {Angew. Chem. Int. Edit.}, title = {ATP-inducible receptor oligomerization enables fine-tuning of t cell immunity}, volume = {64}, year = {2025}, }
• (2025). Deciphering the role of lattice selenium in electrocatalytic self-reconstruction for boosting alkaline hydrogen evolution. ANGEW, 64(33), e202507040. (www)

  @article{ , abstract = {Cathode reconstruction is equally crucial for water electrolysis, yet it has received less attention than anode. Lattice selenium (Se) doping is an effective strategy to improve hydrogen evolution reaction (HER) of metal-based electrocatalysts in cathodes, but many fundamental questions concerning the actual role of Se on the active species as well as catalytic kinetics remain to be clarified, especially in those electrocatalytic self-reconstruction systems. Here, we showcase the accelerated two-stage structural evolution of Se-doped cobalt phosphide (Se-CoP) during alkaline HER by operando X-ray absorption spectroscopy and powder X-ray diffraction, combined with high-resolution transmission electron microscopy (HRTEM) analysis. Further density functional theory (DFT) calculations suggest that the in situ formed dual-component heterostructure of highly crystalline Co(OH) 2 and robust Co nanoclusters, which are decorated with residual Se, is responsible for the high HER performance. The reconstructed Se-CoP on carbon cloth delivers a low overpotential of 79 ± 2 mV at 100 mA · cm −2 and achieves an impressive charge transfer amount of 6.3 × 10 5 C cm −2 operating at 500 mA cm −2 , surpassing the reported electrocatalysts constructed by non-noble metal phosphides. This work provides brand-new perspectives on the self-reconstruction perturbed by heteroatoms for well-designed composite electrocatalysts.}, archive = {J_ANGEW}, author = {Xiao-Han Zhang and Meng-Tian Zhang and Hong-Gang Du and Hai-Hua Huang and Xue-Feng Zhang and Xia Wen and Li-Dong Wang and Wei-Zhen Deng and Yu-Mei He and Jie Bai and Li-Wen Ding and Chun-Ting He}, doi = {10.1002/anie.202507040}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202507040}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering the role of lattice selenium in electrocatalytic self-reconstruction for boosting alkaline hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Chiral selenium-integrated multi-resonant thermally activated delayed fluorescent emitters showing improved reverse intersystem crossing rate. ANGEW, 64(33), e202506999. (www)

  @article{ , abstract = {Nitrogen/carbonyl (N/C═O) based multi-resonant thermally activated delayed fluorescence (MR-TADF) emitters are attractive due to their bright, narrowband emission and the ease with which they can be synthesized. However, their photophysics typically suffer from slow reverse intersystem crossing (RISC) because of their relatively large singlet-triplet energy gap (Δ E ST ). Thus, the organic light-emitting diodes (OLEDs) with these emitters typically show severe efficiency roll-off. Here, two MR-TADF emitters DiKTaSe and tBuCz-DiKTaSe have been designed and synthesized. The introduction of selenium in the form of an annelated benzoselenophene enhances spin-orbit coupling and increases the RISC rate. The twisted ortho -substituted tert -butylcarbazole moiety in tBuCz-DiKTaSe helps to suppress aggregation-caused quenching of the emission in films. In addition, the large size of the selenium atom and long C─Se bonds induce helical chirality in both DiKTaSe and tBuCz-DiKTaSe . Finally, the OLEDs with DiKTaSe showed maximum external quantum efficiency (EQE max ) of 22.7% while OLEDs with tBuCz-DiKTaSe showed a higher EQE max of 27.8% and less-pronounced efficiency roll-off, with EQE at 100 cd m −2 (EQE 100 )/ EQE at 1000 cd m −2 (EQE 1000 ) of 23.5/12.5%. These efficiency values are amongst the highest of devices employing DiKTa-based emitters. Our work provides key insight into how to judiciously employ heavy atoms to increase the performance of the emitter and the device.}, archive = {J_ANGEW}, author = {Jingxiang Wang and Hassan Hafeez and Dongyang Chen and Jhon Sebastian Oviedo Ortiz and Yan Xu and Aidan P. McKay and David B. Cordes and Jeanne Crassous and Ifor D. W. Samuel and Eli Zysman-Colman}, doi = {10.1002/anie.202506999}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506999}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral selenium-integrated multi-resonant thermally activated delayed fluorescent emitters showing improved reverse intersystem crossing rate}, volume = {64}, year = {2025}, }
• (2025). A nitrogen-containing graphenic buckybowl for photocatalysis and assembly with fullerenes. ANGEW, 64(33), e202506862. (www)

  @article{ , abstract = {A nitrogen-containing graphenic buckybowl (3N-HBC) has been synthesized through pentagonal cyclization at the bay positions of hexa- peri -hexabenzocoronene ( p -HBC) using a Pd-catalyzed dehydrogenative cycloamination as a key step. The incorporation of three pyrrole rings to the periphery of the bowl endows it with strong electron-rich character, showing three reversible oxidations in cyclic voltammetry (CV), and thus could be progressively oxidized into cationic radical and high-charged species upon gradual addition of the oxidant. Interestingly, the cationic radical was also generated by acids, which could be significantly accelerated by light, whether under an air or inert atmosphere. 3N-HBC exhibits interesting properties that arise from its electron-rich character and the unique curved geometry. 3N-HBC proved to be a superior organic photocatalyst for the conversion of 2-isocyanobiphenyl to phenanthridine derivatives at 1.0 mol% catalytic loading under blue LEDs irradiation. Furthermore, the electron-donating nature and curved π-surface of 3N-HBC enable its association with fullerenes (C 60 and C 70 ) in solution and solid states. This work also demonstrates that nanographene sheets can be bent to π-bowls through the introduction of a few pentagons containing small-sized heteroatoms to their bay regions.}, archive = {J_ANGEW}, author = {Huiling Liu and Jimin Guo and Tiantian Che and Changhua Ding and Bin Xu and Qitao Tan}, doi = {10.1002/anie.202506862}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506862}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A nitrogen-containing graphenic buckybowl for photocatalysis and assembly with fullerenes}, volume = {64}, year = {2025}, }
• (2025). An integrated tandem-structured separator enables dual-enhanced stable interfaces for long-cycle-life and high-areal-capacity aqueous Zinc–Iodine batteries. ANGEW, 64(33), e202506849. (www)

  @article{ , abstract = {Aqueous zinc–iodine batteries (AZIBs) hold great promise for next-generation energy storage technologies due to their inherent safety, cost-effectiveness, and environmental friendliness. However, unstable interfacial chemistry manifested as polyiodide formation and accumulation at the cathode, alongside dendrite growth and hydrogen evolution reaction (HER) at the anode results in capacity loss. Moreover, polyiodide migration toward the anode further triggers severe Zn corrosion, exacerbating interfacial instability. Herein, we design an integrated tandem-structured separator comprising an In 2 O 3 -SiO 2 (ISO) layer with a buffer-release-repair mechanism and a polyiodide adsorption–catalysis layer featuring Co nanoparticles-encapsulated carbon nanofiber (Co@CNF) to achieve dual-enhanced stable interfaces. Specifically, amphoteric In 2 O 3 within the ISO layer effectively neutralizes OH⁻ generated by localized HER, concurrently releasing soluble indium species. These indium species subsequently electrodeposit to form zincophilic and HER-inhibiting sites on the affected regions, restoring interfacial environment and mitigating Zn anode degradation. Meanwhile, the Co@CNF layer anchors polyiodides and significantly catalyzes conversion kinetics, suppressing the shuttle effect and preventing polyiodide-induced anode corrosion. Benefiting from the synergistic stabilization of both electrode interfaces, the as-fabricated Zn||ISO + Co@CNF||I 2 full cells achieve a high areal capacity of 2.97 mAh cm −2 and remarkable cycling stability over 20 000 cycles. This work provides valuable insights into designing functional separators for practical AZIBs.}, archive = {J_ANGEW}, author = {Siyang Li and Chenxi Sun and Minghao Zhang and Rong Tang and Minghui Chen and Weiwei Meng and Jin Yang and Yuanhong Kang and Zeheng Lv and Jinbao Zhao and Yang Yang}, doi = {10.1002/anie.202506849}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506849}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An integrated tandem-structured separator enables dual-enhanced stable interfaces for long-cycle-life and high-areal-capacity aqueous Zinc–Iodine batteries}, volume = {64}, year = {2025}, }
• (2025). Modulating spin state of ni single atomic center for high-performance electrocatalytic carbon dioxide reduction. ANGEW, 64(33), e202506845. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) have been widely investigated and regarded as promising electrocatalysts for carbon dioxide reduction. However, studies on the impact of coordinated-nitrogen species in the active center on the spin state and catalytic activity remain scarce. Herein, two single Ni atom electrocatalysts with distinct pyridinic-N and pyrrolic-N coordination through a rapid Joule-heating method that preserves precursor nitrogen configurations. Magnetic susceptibility measurements reveal that pyridinic-N induces a high-spin state in Ni centers, while pyrrolic-N stabilizes a low-spin configuration. The high-spin Ni–N pyridinic –C demonstrates an exceptional performance in electrocatalytic CO 2 reduction, achieving 98.8% CO Faradaic efficiency in H-cells and maintaining >99% Faradaic efficiency at industrial current densities (≥250 mA cm −2 ) across alkaline, neutral, and acidic electrolytes in a gas-diffusion flow cell. A maximum power density of 1.89 mW cm −2 and excellent charge–discharge cyclability also achieve in zinc–CO 2 battery, further demonstrating the applicability of Ni–N pyridinic –C. Theoretical calculations demonstrate that the high-spin state enhances d-orbital dispersion, strengthening hybridization with π* orbital of CO 2 and stabilizing *COOH intermediates, thereby accelerating CO 2 activation. This study not only establishes a novel strategy for spin-state engineering through coordination control but also advances scalable electrocatalyst design for efficient carbon cycling.}, archive = {J_ANGEW}, author = {Zhen Chen and Jiankang Liu and Jianpeng Li and Yueteng Zhang and Jia Yang and Jun Li and Zhiyuan Wang and Zhongyi Liu and Shuang-Quan Zang}, doi = {10.1002/anie.202506845}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506845}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating spin state of ni single atomic center for high-performance electrocatalytic carbon dioxide reduction}, volume = {64}, year = {2025}, }
• (2025). A structure-preserving, dimensionality-increasing strategy for the stepwise synthesis of microporous α-MoO3 with a broad (100) surface. ANGEW, 64(33), e202506758. (www)

  @article{ , abstract = {Metal oxides with diverse structures and dimensionalities are typically synthesized via solid-state or hydrothermal reactions. However, it is quite difficult to retain the structures of the starting materials when 0D metal salts or molecular clusters are used as precursors because higher-dimensional structures form by structural reorganization through isomerization and decomposition/condensation reactions. In this study, we demonstrated a structure-preserving, dimensionality-increasing strategy for the synthesis of 2D α-MoO 3 from 0D [Mo 2 O 5 (H 2 O) 6 ] 2+ species via a 1D [Mo 2 O 6 {(CH 3 ) 2 NCHO}] n intermediate while maintaining the structures of the precursors. By simple temperature-controlled calcination, metastable crystals of α-MoO 3 in which the (100) plane was the broad face were successfully synthesized, differing from conventional α-MoO 3 in which the (010) plane is the broad face. In addition, the prepared metastable crystals possessed large surface areas, unusual micropores, and surface-exposed coordinatively unsaturated Mo sites, allowing them to serve as high-performance acid catalysts. This synthesis strategy is expected to facilitate the synthesis of metastable structures and the design of defects and surface structures at the atomic level.}, archive = {J_ANGEW}, author = {Takuo Minato and Misato Miyamoto and Satoshi Ishikawa and Norihito Hiyoshi and Makoto Maeda and Kenji Komaguchi and Masahiro Sadakane}, doi = {10.1002/anie.202506758}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506758}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A structure-preserving, dimensionality-increasing strategy for the stepwise synthesis of microporous α-MoO3 with a broad (100) surface}, volume = {64}, year = {2025}, }
• (2025). Strain-enabled radical-polar crossover annulation to access spiro-, fused-, and enantioenriched-Aza/Oxa-Bicyclo[3.1.1]Heptanes. ANGEW, 64(33), e202506747. (www)

  @article{ , abstract = {Conformationally rigid bridged bicyclic scaffolds have emerged as bioisosteric replacements for planar aromatic rings. However, bioisosteric mimetics of heteroaromatic rings have been investigated less due to the challenges of incorporating heteroatoms into bicycloalkanes. Herein, we report a unified strategy to access both aza- and oxa-bicyclo[3.1.1]heptanes in a single experimental protocol from a readily accessible amino/hydroxy acid derivative under photoredox catalysis. The reaction exhibits a broad scope across a range of redox-active esters and bicyclo[1.1.0]butanes (BCBs) and successfully provides previously inaccessible spiro- and fused-hetero-bicyclo[3.1.1]heptanes. Noteworthy, chiral amino/hydroxy acid derived redox-active esters could be used to access enantioenriched hetero-bicyclo[3.1.1]heptanes. Furthermore, the strategy has been extended to access aza-bicyclo[2.1.1]hexanes, another important motif in medicinal chemistry. The functional groups introduced during the reaction serve as a synthetic handle for downstream manipulations, thus offering opportunities to build up molecular complexity rapidly. Density functional theory calculations and experimental studies support an oxidative radical-polar crossover (RPC) mechanism and rationalize the observed regioselectivity.}, archive = {J_ANGEW}, author = {Bhismalochan Ghorai and Buddhadeb Sahana and Durga Prasad Hari}, doi = {10.1002/anie.202506747}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506747}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strain-enabled radical-polar crossover annulation to access spiro-, fused-, and enantioenriched-Aza/Oxa-Bicyclo[3.1.1]Heptanes}, volume = {64}, year = {2025}, }
• (2025). Supramolecular Host–Guest assemblies for tunable and modular lysosome-targeting protein degradation. ANGEW, 64(33), e202506618. (www)

  @article{ , abstract = {Heterobifunctional drugs have revolutionized chemical biology and therapeutic innovation, yet their fixed covalent linkages constrain dynamic adaptability. Here, we introduce host–guest bridged lysosome-targeting chimeras (HGTACs), a supramolecular bifunctional platform that utilizes β-cyclodextrin-adamantane host–guest interactions to achieve tunable and modular assembly. HGTACs effectively facilitated lysosomal degradation of both extracellular and transmembrane proteins, including NS-650, epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2. By deconstructing lysosome-targeting chimeras into host and guest components, HGTACs enable spatiotemporal control over protein degradation through noncovalent bridging. This strategy allows for the fine-tuning of degradation efficiency by adjusting stoichiometric ratios and introducing competitive ligands. Notably, the recyclable nature of the asialoglycoprotein receptor-binding host module conferred sustained degradation activity. In vivo, EGFR-targeting HGTACs significantly reduced EGFR protein levels and suppressed tumor growth in xenograft models. This supramolecular control system reshapes lysosome-targeting chimeras, providing a flexible and efficient strategy for advancing chemically induced proximity-based modalities.}, archive = {J_ANGEW}, author = {Xuetao Chen and Tingting Wu and Yali Chen and Huidan Wu and Wenjing Kang and Nan Wang and Qidong You and Xiaoke Guo and Zhengyu Jiang}, doi = {10.1002/anie.202506618}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular Host–Guest assemblies for tunable and modular lysosome-targeting protein degradation}, volume = {64}, year = {2025}, }
• (2025). Embedded-type cu nanoparticle with largely enhanced catalytic activity and stability toward methanol steam reforming. ANGEW, 64(33), e202506458. (www)

  @article{ , abstract = {Hydrogen production through low-temperature methanol steam reforming (MSR) reaction plays a critical role in the development of new energy but remains a great challenge. Herein, we report a Cu/Zn(Ga)O x catalyst, which is prepared via an interface reconstruction strategy. Interestingly, this catalyst is featured with a unique mortise-and-tenon structure: Cu nanoparticles are embedded into the Zn(Ga)O x substrate, which ensures a stable Zn–O–Cu + –O v –Ga δ + interface structure. The resulting Cu/Zn(Ga)O x catalyst exhibits 99.3% CH 3 OH conversion with an H 2 production rate of 124.6 µmol g cat −1 s −1 at 225 °C, which is preponderant to the state-of-the-art catalysts. Furthermore, an ultra-high catalytic stability was demonstrated through a 400 h stream-on-line test without obvious decline. Kinetic isotope analysis, in situ spectroscopy characterizations, and theoretical calculations reveal that the MSR reaction over Cu/Zn(Ga)O x catalyst follows the formaldehyde oxidation route. The CH 3 O* and H 2 O molecule adsorb at the adjacent Cu + −O v interface (intrinsic active site) with an oxygen-terminal adsorption configuration, which promotes electron transfer from the d -band center of Cu to the O ( s , p )-band of the substrate molecule. This significantly reduces the energy barrier of C─H bond cleavage in CH 3 O* dehydrogenation (the rate-determining step) and H 2 O dissociation, accounting for the extraordinarily enhanced H 2 production.}, archive = {J_ANGEW}, author = {Hao Meng and Tianyao Shen and Zhiming Yin and Yusen Yang and Jian Zhang and Kai Feng and Shaoteng Yuan and Lei Wang and Enze Xu and Lirong Zheng and Song Hong and Feng-Shou Xiao and Min Wei}, doi = {10.1002/anie.202506458}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506458}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Embedded-type cu nanoparticle with largely enhanced catalytic activity and stability toward methanol steam reforming}, volume = {64}, year = {2025}, }
• (2025). Insight into the carbon monoxide reduction reaction on cu(111) from operando electrochemical X-ray photoelectron spectroscopy. ANGEW, 64(33), e202506402. (www)

  @article{ , abstract = {In this work, we introduce a modified dip-and-pull electrochemical X-ray photoelectron spectroscopy (ECXPS) approach that offers new mechanistic insight into the alkaline carbon monoxide reduction reaction (CORR) over a Cu(111) single crystal surface. We tackle two major unresolved questions in the CORR mechanism that persist in the literature. Firstly, we address the mechanism for methane formation on Cu(111) and show that the mechanism likely proceeds via atomic carbon, which subsequently couples, leading to the accumulation of amorphous carbon on the surface. Secondly, we provide insight into whether the mechanism for acetate formation occurs entirely on the surface or partially within the solution phase, showing that acetate is present on the surface, indicating a surface-based reaction. These insights into surface-based mechanisms provide a handle for designing future catalysts that can efficiently target the binding of specific intermediates. Furthermore, we expect that our modified approach to dip-and-pull ECXPS – in which we have changed the electrode geometry, the method of introducing the reactant gas and used hard x-rays – will significantly expand the technique's applicability, enabling studies of the CO (2) RR and beyond.}, archive = {J_ANGEW}, author = {Bernadette Davies and Fernando Garcia-Martinez and Christopher M. Goodwin and David Degerman and Markus Soldemo and Patrick Lömker and Vladimir Grigorev and Sara Boscolo Bibi and Harri Ali-Löytty and Robin Y. Engel and Joakim Halldin Stenlid and Gabriel L. S. Rodrigues and Tony Hansson and Christoph Schlueter and Xiaodong Zou and Anders Nilsson and Sergey Koroidov}, doi = {10.1002/anie.202506402}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insight into the carbon monoxide reduction reaction on cu(111) from operando electrochemical X-ray photoelectron spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Phosphorylation regulation promotes bidirectional dynamic adaptive interface for achieving stable Zn–I2 batteries. ANGEW, 64(33), e202506380. (www)

  @article{ , abstract = {Unstable electrode–electrolyte interfaces resulting from severe cathodic polyiodide shuttling, anodic parasitic corrosion reactions, and dendrite growth significantly impede the performance of zinc–iodine (Zn–I 2 ) batteries. Here, phosphorylation regulation is proposed to create dynamically adaptive water-lean interfaces for long-term Zn–I 2 batteries. Phosphorylation reinforces the adaptive interface construction through the increased adsorption capability on the Zn anode and introduces a dynamic pH-balancing capability while simultaneously offering extra sites for the real-time capture of polyiodide intermediates at the cathode. Consequently, extended durability (4400 h at 5 mA cm −2 and 1 mAh cm −2 ), boosted coulombic efficiency (99.8% for 7500 cycles), and ultralong cycling for 8000 cycles at a high loading of 10 mg cm −2 were maintained. These findings provide crucial insights into the optimization of adaptive interfaces through phosphorylation regulation for high-performance Zn–I 2 batteries.}, archive = {J_ANGEW}, author = {Zhenxin Lin and Hanlin Ding and Xiaoting Lin and Minghui Ye and Zhipeng Wen and Yongchao Tang and Xiaoqing Liu and Yufei Zhang and Cheng Chao Li}, doi = {10.1002/anie.202506380}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506380}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phosphorylation regulation promotes bidirectional dynamic adaptive interface for achieving stable Zn–I2 batteries}, volume = {64}, year = {2025}, }
• (2025). Chiral supramolecular clamps for the passive cell diffusion of DNA and siRNA. ANGEW, 64(33), e202506136. (www)

  @article{ , abstract = {The safe and effective delivery of DNA and RNA therapeutics continues to be a major hurdle toward personalized medicine, mainly due to the digestion of this genetic material during endosomal uptake. Herein, we designed a hydrophobic nonionic urea-linked molecular clamp (mol-clamp) based on guanine and phenylalanine (GFUFG) that can readily complex nucleic acids and transport them into cells through passive diffusion. The optimal chiral self-assembled state was achieved by controlling the dimethyl sulfoxide to water ratio in the solvent mixture. Dictated by the presence of hydrophobic moieties in the mol-clamp, a secondary structure was formed through intermolecular hydrogen bonding. The negatively charged complex of mol-clamped nucleic acids was delivered in high efficiency as indicated by the signal of fluorescently labeled ssDNA to both the cytoplasm and the nucleus. The actual efficacy of GFUFG was further evaluated by delivering functional single-stranded DNA (DNAzyme) and siRNA (si-BCL-2), which downregulated EGR-1 and BCL-2 by 44% and 53%, respectively. We envisage that designing mol-clamps that can effectively complex genetic materials and promote passive diffusion rather than endocytosis can improve the field of biologics delivery for individualized therapy and cellular engineering.}, archive = {J_ANGEW}, author = {Batoul Maatouk and Bappa Maiti and Aliyah Fakim and Vivekanand Sharma and Niveen M. Khashab}, doi = {10.1002/anie.202506136}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506136}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral supramolecular clamps for the passive cell diffusion of DNA and siRNA}, volume = {64}, year = {2025}, }
• (2025). Aluminum distribution in ferrierite zeolites influences the performance of methane oxidation. ANGEW, 64(33), e202506023. (www)

  @article{ , abstract = {Transition-metal-free aluminosilicate FER-type zeolite has been demonstrated to effectively catalyze methane to methanol using N 2 O as the oxidant with distorted tetra-coordinated aluminum (Al IV-2 ) and penta-coordinated aluminum (Al V ) as potential active sites. However, the specific effects of Al distribution on the active Al species have not been thoroughly investigated. Herein, aluminosilicate FER-type zeolites with controllable Al distribution were developed. Al distribution, including the arrangement and location of Al atoms, was characterized using 27 Al MQMAS/MAS and 29 Si MAS NMR spectra. The arrangement of aluminum, particularly the isolated Al and paired Al in as-synthesized samples, influenced the proximity between oxidative and acidic sites in H-type samples. Al locations involved the specific positioning of bifunctional sites and affected the final product. The increased CH 4 conversion at 250–275 °C of FER zeolite with Al preferential population at T4 sites confirmed the higher activity of Al species from T4 sites. Additionally, a higher proportion of Al atoms in 10-ring channels facilitated the tandem conversion of methane to methanol on oxidative sites, followed by methanol to hydrocarbons on acidic sites at 300–375 °C. This study corroborated and expanded upon our recent research and highlighted the significant impact of Al distribution in FER zeolite on methane oxidation.}, archive = {J_ANGEW}, author = {Peipei Xiao and Xiaomin Tang and Hiroto Toyoda and Yilin Wang and Anmin Zheng and Lizhuo Wang and Jun Huang and Masato Sawada and Kengo Nakamura and Yong Wang and Hermann Gies and Toshiyuki Yokoi}, doi = {10.1002/anie.202506023}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202506023}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aluminum distribution in ferrierite zeolites influences the performance of methane oxidation}, volume = {64}, year = {2025}, }
• (2025). Axial-N induced square-pyramidal crystal filed of atomically iron sites for enhancing acidic oxygen reduction. ANGEW, 64(33), e202505937. (www)

  @article{ , abstract = {Atomically dispersed Fe-based catalyst represents a promising alternative to platinum for the oxygen reduction reaction (ORR). However, the prevalent FeN 4 configuration exhibits limited intrinsic activity in acidic media owing to its inherent instability, thereby restricting its application in proton exchange membrane fuel cell (PEMFC). Herein, we introduce axial-N coordination to enhance the activity and stability of atomically dispersed Fe sites for acidic ORR by establishing a barrier to prevent Fe dissolution. Compared to the FeN 4 configuration, the axial-N ligand in the FeN 5 , FeN 5 -Fe 3, and FeN 2 C 3 configurations induces a square-pyramidal crystal field, which diminishes the spin polarization in the d z 2 , d xz , and d yz orbitals, and alters the electronic delocalization of Fe atom. In a 0.10 M HClO 4 electrolyte, the ORR activity increases with enhanced electronic delocalization, following the trend: FeN 5 >FeN 5 +Fe 3 >FeN 2 C 3 >FeN 4 . Operando technique further reveals that the dissociation of Fe─N bond in the FeN 5 configuration occurs alongside the insertion of oxygen, leading to the formation of FeN 3 O 2 and FeN 4 O 1 structures that could accelerate the ORR kinetics. Consequently, the FeN 5 configuration shows a positive shift of 30 mV in half-wave potential compared to Pt/C and achieves a peak power of 1.2 W cm −2 at 3.2 A cm −2 in PEMFC.}, archive = {J_ANGEW}, author = {Di Shen and Fanfei Sun and Zhijian Liang and Honggang Fu and Lei Wang}, doi = {10.1002/anie.202505937}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505937}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Axial-N induced square-pyramidal crystal filed of atomically iron sites for enhancing acidic oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). Zwitterion-modified NiFe OER catalyst achieving ultrastable anion exchange membrane water electrolysis via dynamic alkaline microenvironment engineering. ANGEW, 64(33), e202505924. (www)

  @article{ , abstract = {The development of efficient nonprecious metal electrocatalysts for industrial anion exchange membrane water electrolysis (AEM-WE) remains challenging, primarily due to sluggish OH − transfer from the anion exchange membrane (AEM) to catalytic sites, causing H + accumulation and performance degradation. Herein, we developed a zwitterion-modified NiFe catalyst (z-NiFe) through gradient soaking, facilitates rapid OH − transfer across the AEM-electrocatalyst interface, effectively neutralizing the generated H + and enhancing catalytic performance. In-situ Raman spectroscopy and OH − conductivity measurements reveal an alkaline-enriched surface environment, which inhibits H + accumulation-induced chemical corrosion and enhances water oxidation performances. Density functional theory (DFT) analysis demonstrates that zwitterions stabilize adsorbed oxygen during catalysis, and reduce the overpotential of oxygen evolution reaction (OER). The z-NiFe shows an ultralow Tafel slope (28.5 mV dec −1 ) and high activity (190 mV overpotential at 1000 mA cm −2 ) in 1 M KOH. When integrated into an AEM-WE system, the z-NiFe-catalyzed AEM-WE device exhibits a low cell voltage of 1.76 V at 1000 mA cm −2 and record-breaking durability over 14000 h, with a voltage degradation rate of 12.3 µV h −1 , representing a significant advancement in AEM-WE technology.}, archive = {J_ANGEW}, author = {Wenlong Li and Yunxuan Ding and Yilong Zhao and Zhiheng Li and Gaoxin Lin and Linqin Wang and Licheng Sun}, doi = {10.1002/anie.202505924}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zwitterion-modified NiFe OER catalyst achieving ultrastable anion exchange membrane water electrolysis via dynamic alkaline microenvironment engineering}, volume = {64}, year = {2025}, }
• (2025). Mediating solid electrolyte interphase formation kinetics on SiOx anodes using proton acceptors. ANGEW, 64(33), e202505832. (www)

  @article{ , abstract = {Silicon (Si)-based anodes offer high energy density but suffer from significant volume variations, leading to an unstable solid electrolyte interphase (SEI). To enhance SEI stability, numerous electrolyte additives have been designed to decompose on the anode and form desirable SEI components (e.g., LiF). However, their electrochemical reduction kinetics on the anode surface competes with other electrolyte components, leading to suboptimal interfacial decomposition efficiency and a less stable SEI structure. Here, inspired by bioremediation strategies in petroleum pollution treatment, we introduce a proton acceptor that reacts with fluoroethylene carbonate (FEC), a commercially established additive, to generate an intermediate. Such an intermediate lowers the reduction kinetic barrier, accelerating the formation of LiF and enriching it in the inner layer of the SEI. Compared to the randomly distributed LiF structure, the resulting SEI exhibits better mechanical stability and lithium-ion conduction, effectively accommodating volume changes and mitigating stress concentration caused by local overlithiation. As a result, the electrochemical performance surpasses that of previously reported works. This intermediate-based strategy significantly improves the utilization efficiency of commercial additives, offering a practical direction for future electrolyte design.}, archive = {J_ANGEW}, author = {Haoliang Wang and Hao Zhang and Lu Wang and Zhibo Song and Wenguang Zhao and Zhaohuang Zhan and Jianjun Fang and Yuxiang Huang and Zu-Wei Yin and Feng Pan and Luyi Yang}, doi = {10.1002/anie.202505832}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505832}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mediating solid electrolyte interphase formation kinetics on SiOx anodes using proton acceptors}, volume = {64}, year = {2025}, }
• (2025). Ultrafast (600 ps) vacuum-UV reflective scintillation enabled by surface exciton recombination in layered perovskite PEA2PbBr4. ANGEW, 64(33), e202505665. (www)

  @article{ , abstract = {Vacuum ultraviolet (VUV) photodetection is pivotal for space exploration and radiation monitoring, yet its dynamic imaging capability is significantly hindered by the slow response of conventional scintillators. However, existing scintillators exhibit microsecond-to-nanosecond decay time, failing to meet sub-nanosecond ultrafast imaging demands. Here, we uncovered a surface exciton recombination mechanism in layered perovskite PEA 2 PbBr 4 , where lattice contraction induced exciton localization, achieving ultrafast decay time of 600 ps—over 100-fold faster than commercial scintillation. A reflective optical configuration was designed to suppress self-absorption, improving the light utilization efficiency. This work established a material paradigm for ultrafast dynamic imaging and opens avenues for advancing space science and high-energy physics detection.}, archive = {J_ANGEW}, author = {Danwen Zhang and Lu Cheng and Xiaoyu Song and Xin Zhang and Lixin Zhang and Siqi Zhu and Mingxi Hu and Yang Liu and Xiaoping Ouyang and Wei Zheng}, doi = {10.1002/anie.202505665}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505665}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrafast (600 ps) vacuum-UV reflective scintillation enabled by surface exciton recombination in layered perovskite PEA2PbBr4}, volume = {64}, year = {2025}, }
• (2025). Mixed-metal ce-zr-mn clusters as photo-catalysts for decarboxylative functionalization of carboxylic acids. ANGEW, 64(33), e202505639. (www)

  @article{ , abstract = {Decarboxylative hydrazination of carboxylic acids was achieved using a 1:5:2 ratio of three metal salts, Ce(O t Bu) 4 , Zr(O t Bu) 4 , and Mn(OAc) 3 , as a catalyst under visible light irradiation. The catalytic activity, compared with our previously developed Ce 6 cluster photo-catalysts, was enhanced by the formation of single cerium-incorporated hexanuclear mixed-metal clusters containing a [CeZr 5 O 4 (OH) 4 ] 12+ core. The manganese salts further accelerated the overall reaction rate (10 times faster reaction rate with the manganese salt than that of the manganese-free conditions). Using the isolated cluster, CeZr 5 O 4 (OH) 4 (OCOCH 2 t Bu) 12 (HOCOCH 2 t Bu) 4 ( 4a ), with Mn(OAc) 3 , phenol and thiophenol-containing carboxylic acids were transformed to their decarboxylative hydrazinated products in moderate to high yields, while a mixture of Ce 6 O 4 (OH) 4 (OCOCH 2 t Bu) 12 (HOCOCH 2 t Bu) 4 ( 4c ) and Mn(OAc) 3 or Ce(O t Bu) 4 , Zr(O t Bu) 4 , and Mn(OAc) 3 yielded lower amounts of the products. These findings highlight the importance of incorporating cerium(IV) into the zirconium-based core to tolerate these easily oxidizable functional groups. Upon exposure of 4a to blue LED light under an argon atmosphere, the CeZr 5 cluster produced 2,2,5,5-tetramethylhexane, a radical coupling product derived from the carboxylate ligand on 4a , in half an equivalent per cluster, consistent with the photo-reduction of cerium(IV) and inertness of the oxo- and hydroxo-bridged Zr 5 motif as a metallo-ligand around the cerium(IV) site. Moreover, decarboxylative oxygenation of carboxylic acids under air followed by treatment with NaBH 4 resulted in the production of one-carbon shortened alcohols in excellent yields when using Ce(O t Bu) 4 and Zr(O t Bu) 4 or Hf(O t Bu) 4 in a 1:5 ratio: the reaction rates were 8–10 times higher than that of the previously developed cerium-catalyzed reaction under identical conditions.}, archive = {J_ANGEW}, author = {Sota Tamaki and Riina Kuwata and Shuto Wakita and Yasuko Osakada and Mamoru Fujitsuka and Tetsuro Kusamoto and Kazushi Mashima and Hayato Tsurugi}, doi = {10.1002/anie.202505639}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505639}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mixed-metal ce-zr-mn clusters as photo-catalysts for decarboxylative functionalization of carboxylic acids}, volume = {64}, year = {2025}, }
• (2025). A strong and tough thermosetting epoxy resin for recyclable high-performance composites. ANGEW, 64(33), e202505526. (www)

  @article{ , abstract = {Epoxy-based carbon fiber-reinforced composites (EP-CFRCs) are appealing for engineering applications due to their exceptional specific strength and modulus. Nevertheless, the intrinsic brittleness and limited recyclability of highly cross-linked epoxy matrices pose significant challenges to their sustainable development. Herein, we present an approach combining dynamic ester bonds with semi-interpenetrating polymer networks (SIPNs) to overcome these challenges. This strategy leverages the crosslinked epoxy network to resist deformation, while hydrogen bonds and entangled SIPNs to facilitate energy dissipation, enhancing both strength and toughness. The resultant epoxy matrix exhibits superior tensile strength of 123 MPa and record-breaking impact strength of 52.3 kJ m −2 , effectively overcoming the long-standing trade-off between strength and toughness in thermosets. This balanced performance renders it a promising matrix for high-performance EP-CFRCs, which display a tensile strength of 718 MPa and a bending deflection of 0.59 mm. Moreover, the embedded tertiary amines accelerate transesterification reactions, enabling closed-loop recycling of EP-CFRCs in water. The recycled carbon fibers and the degraded matrix can be reused in new composites and adhesives. This work presents a simple yet effective strategy for designing epoxy resin-based composites that overcome the limitations of traditional matrices and support the development of recyclable advanced materials for diverse industrial applications.}, archive = {J_ANGEW}, author = {Dongxu Pei and Peisen Wang and Jie Hao and Yucheng Zi and Ousheng Zhang and Jigang Yang and Jianhua Tang and Jun Hu}, doi = {10.1002/anie.202505526}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505526}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A strong and tough thermosetting epoxy resin for recyclable high-performance composites}, volume = {64}, year = {2025}, }
• (2025). A cobotic, digitally controlled schlenk-line unlocks access to elusive lewis-base stabilised copper Bis(Disilylamides). ANGEW, 64(33), e202505408. (www)

  @article{ , abstract = {Silylamides are important ligands in coordination chemistry for their ability to stabilise low coordination numbers and provide soluble, and even volatile, metal complexes. Such compounds provide valuable insights into the fundamental bonding and reactivity of their respective metals. Despite the wealth of homo- and heteroleptic hexamethyldisilazide complexes of divalent 3 d ions (Sc-Ni, Zn), attempts to access the corresponding divalent copper complexes have yielded only Cu(I) species. Herein, we demonstrate the stabilisation and isolation of a formally Cu(II) bis-hexamethyldisilazide which was achieved by implementing novel digital chemistry tools. In order to successfully isolate (DMAP)Cu II (N{SiMe 3 } 2 ) 2 (DMAP = N,N-dimethylaminopyridine), we investigated the roles of the co-ligand and silylamide transfer reagent in the kinetics of its formation. Crucial to these studies was our newly developed “cobotic” Schlenk line which provides digital control of the atmosphere under which we conduct our highly reactive syntheses. In digitising Schlenk-line handling, we have improved synthetic productivity by creating protocols for automated inertisation, solvent evaporation, liquid handling and crystallisation all while capturing reaction log data. Importantly, our Cu silylamide synthesis provides a case study showing that our cobotics approach allows for the discovery and isolation of unstable species which may remain elusive by traditional manual or fully autonomous methodologies.}, archive = {J_ANGEW}, author = {Nicola L. Bell and Marina Gladkikh and Cameron Fraser and Mostafa Elsayed and Emma Richards and Richard Drummond Turnbull}, doi = {10.1002/anie.202505408}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505408}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A cobotic, digitally controlled schlenk-line unlocks access to elusive lewis-base stabilised copper Bis(Disilylamides)}, volume = {64}, year = {2025}, }
• (2025). Multifunctional and radii-matched high-entropy engineering toward locally-regulable metal oxide layers in sodium-layered oxide cathode. ANGEW, 64(33), e202505367. (www)

  @article{ , abstract = {Layered oxides, one of the most fascinating cathodes for sodium-ion batteries (SIBs), have appropriate voltage window and feasible preparation process, however, cycling stability is the biggest challenge. Element doping is the most rational strategy to address this problem, but six-coordinated octahedral radii and different radii in different valence states of these doping elements and the functions of these elements need to be taken into account. Hence, an example of P2/O3-type Na 0.7 Mn 0.53 Ni 0.26 Fe 0.15 Mg 0.01 V 0.01 Co 0.01 Cu 0.01 Zn 0.01 Sn 0.01 O 2 (high-entropy-doped layered oxides, HEO) has been designed in consideration of moderate six-coordinated octahedral radii and stabling the metal–oxygen bond. A reversible capacity of 126.9 mAh g −1 can be achieved. Even tested at 1000 mA g −1 , an improved rate performance of 72.9 mAh g −1 can be observed with a capacity retention rate of 66.5% after 1000 cycles. Potential-based in situ electrochemical impedance spectroscopy measurements and corresponding distribution of relaxation time profiles prove the effect of multiple elemental combination. Concomitantly, in situ XRD results reveal the P2/O3 biphasic clamping reaction mechanism of HEO. Density functional theory results reveal that the multielement doping can modify the localization of electrons and enhance the structural stability. This work provides an idea of designing HEO cathode for SIBs by crystal structure modulation.}, archive = {J_ANGEW}, author = {Zhi-Xiong Huang and Tian-Qi Yang and Jun-Ming Cao and Kai-Yang Zhang and Yan Liu and Ben-Jian Xin and Kang Xu and Yue Liu and Xin-Yang Zhou and Jin-Zhi Guo and Ting Wang and Hongbo Geng and Xing-Long Wu}, doi = {10.1002/anie.202505367}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505367}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multifunctional and radii-matched high-entropy engineering toward locally-regulable metal oxide layers in sodium-layered oxide cathode}, volume = {64}, year = {2025}, }
• (2025). Efficient harvesting of triplet excitons via a t1-blocked TADF mechanism in series MOFs for optimal X-ray detection and imaging. ANGEW, 64(33), e202505256. (www)

  @article{ , abstract = {Scintillators play vital roles in fields such as medical imaging, high-energy physics, astronomy, and radiation monitoring. Their operational principle, rooted in the excitation of high-energy radiation, underscores that luminescence efficiency in scintillators is fundamentally limited by their capacity to harness triplet excitons. In this context, thermally activated delayed fluorescence (TADF) molecules present a promising avenue, enabling the efficient utilization of triplet excitons through thermally activated up-conversion, thereby advancing the development of superior scintillators. Our investigation reveals a T 1 -blocked TADF mechanism in H 4 TCPE, where efficient singlet-triplet exciton transfer arises from the minimized S 1 -T 2 energy gap (0.18 eV). Unlike conventional TADF molecules, H 4 TCPE features carboxylic acid groups that enable heavy metal coordination to enhance X-ray attenuation. Using tetravalent metals (Zr, Hf, and Th) as nodes and H 4 TCPE as linkers, we fabricated metal-organic frameworks (MOFs) that synergize H 4 TCPE's TADF properties with metal-enhanced radiation absorption. The resulting MOFs show X-ray detection and imaging performances superior to pure H 4 TCPE (20.0 lp mm −1 and 1.15 µGy s −1 for Th-TCPE vs. <14.3 lp mm −1 and 5.01 µGy s −1 for H 4 TCPE), with efficacy correlating to metal atomic number. This work not only broadens TADF molecular diversity through a new energy transfer mechanism and pioneers TADF-MOF integration for advanced radiation detection.}, archive = {J_ANGEW}, author = {Xia Wang and Zhe Zhang and Hui-Li Ma and Zu-Ju Ma and Meng-Jia Yuan and Hai-Jiang Bian and Yi-Cen Liu and Xing-Yun Luo and Fu-Yin Ma and Yan-Long Wang and Yi-Hui Yuan and Ning Wang and Shu-Ao Wang and Wei Liu}, doi = {10.1002/anie.202505256}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505256}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient harvesting of triplet excitons via a t1-blocked TADF mechanism in series MOFs for optimal X-ray detection and imaging}, volume = {64}, year = {2025}, }
• (2025). Chemical coordination induced fullerene dimers on hot pt(111). ANGEW, 64(33), e202505101. (www)

  @article{ , abstract = {The fullerene family is known for its unique properties, facilitating the formation of large, lubricated nano-onions and the fragmentation into small carbon clusters through various processes. In this study, we explore the thermal evolution of islands on Pt(111), focusing on the segregation of islands, the formation of fullerene dimers, and the subsequent development of large graphene sheets. Using noncontact atomic force microscopy and scanning tunneling microscopy, we observed that after annealing at , the islands showed minimal change compared to their deposition at room temperature. However, at , pairs of separated dimers appeared, which, due to their low mobility, have the potential to transform into graphene quantum dots (GQDs). Further annealing at controlled and refined the quality and dimensions of the graphene patches. This process not only provides an effective method for producing high-quality graphene but also permits to preserve isolated dimers on the Pt(111) surface, offering valuable insights for advanced synthesis and lubrication applications.}, archive = {J_ANGEW}, author = {Zhao Liu and Antoine Hinaut and Thilo Glatzel and Ulrich Aschauer and Ernst Meyer}, doi = {10.1002/anie.202505101}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505101}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical coordination induced fullerene dimers on hot pt(111)}, volume = {64}, year = {2025}, }
• (2025). A multifunctional polyester nanoplatform for the synergistic anticancer: Enhanced photodynamic therapy and targeted gene silencing. ANGEW, 64(33), e202505041. (www)

  @article{ , abstract = {Gene therapy (GT) and photodynamic therapy (PDT) present promising approaches for cancer treatment. However, GT is frequently impeded by the lysosomal capture of nucleic acids, while PDT is constrained by low oxygen levels in tumors. Herein, we reported the design of a versatile block polyester vector, BFN 2 , which comprises of a photosensitizer BODIPY ( B ), an oxygen carrying perfluorinated carbon chain ( F ) as well as a GSH-responsive, and RNA-condensing [12]aneN 3 ( N ) moiety. In the presence of DOPE ( D ) and DSPE-PEG-iRGD ( R ), BFN 2 is able to carry oxygen and condense HIF-1α siRNA efficiently and afford hybrid nanoparticles BFN 2 DR/HIF-1α siRNA@O₂ . These combined functionalities work together to reverse tumor hypoxia, remodel the tumor microenvironment, and allow for the efficient lysosomal escape of nucleic acids, thereby significantly boosting the efficacy of PDT and GT in solid tumors. In vitro and in vivo studies demonstrated that the BFN 2 -DR/HIF-1α siRNA@O₂ nanoplatform significantly exhibited substantial inhibitory effects in 4T1 tumors with TGI up to 87%. This research marks the first-in-class integration of such multimodality therapeutic strategies within a single block polymeric vector, thus offering a novel perspective for developing effective oncological treatment paradigms.}, archive = {J_ANGEW}, author = {Xi Zhang and De-Zhong Xu and Wen-Jing Zhao and Xin-Yue Han and Zhong-Lin Lu and Rui Liu}, doi = {10.1002/anie.202505041}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202505041}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A multifunctional polyester nanoplatform for the synergistic anticancer: Enhanced photodynamic therapy and targeted gene silencing}, volume = {64}, year = {2025}, }
• (2025). Synthesis of porous carbon-based network containing ultranarrow nonplanar nanopores on surfaces. ANGEW, 64(33), e202504734. (www)

  @article{ , abstract = {Introduction of twisted structures into low-dimensional graphene-based nanostructures has important ramifications on their inherent physical behavior. The fabrication of graphene derivatives with nonplanar characteristics remains challenging, especially for extended two-dimensional (2D) structures. Herein, we report the synthesis of a novel nonplanar [32]annulene porous carbon-based network that contains the narrowest periodic nanopores and exhibits the highest negative curvature among 2D nonplanar carbon-based nanostructures synthesized up to date. The success is driven by the dissymmetrical debromination and regioselective coupling reactions of precursor molecules on Au(111) surface, as corroborated by scanning tunneling microscopy (STM) and synchrotron radiation photoemission spectroscopy (SRPES). We characterize electronic properties of the [32]annulene porous carbon-based network with the aid of scanning tunneling spectroscopy (STS) and demonstrate a significant hole doping induced by interfacial charge transfer between the nonplanar nanoarchitecture and the Au(111) substrate.}, archive = {J_ANGEW}, author = {Tianchen Qin and Fei Gao and Yulun Wu and Baiyao Liang and Lei Hu and Weishan Yang and Honghe Ding and Jun Hu and Qian Xu and Aran Garcia-Lekue and Dezhou Guo and Tao Wang and Junfa Zhu}, doi = {10.1002/anie.202504734}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202504734}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of porous carbon-based network containing ultranarrow nonplanar nanopores on surfaces}, volume = {64}, year = {2025}, }
• (2025). On-surface synthesis and characterization of tetraazanonacene. ANGEW, 64(33), e202504707. (www)

  @article{ , abstract = {Isosteric replacement of CH units of acenes by nitrogen induces significant changes in their electronic, redox, and spectroscopic properties. Here, we describe the on-surface synthesis of a nonacene analogue substituted with four nitrogen atoms on a Au(111) surface by a two-step atom manipulation, employing a bis vinylene-bridged precursor synthesized in solution. The generated tetraazanonacene has been investigated by scanning tunnelling microscopy/spectroscopy (STM/STS) and noncontact atomic force microscopy (nc-AFM), combined with first-principles calculations. We found that, compared to the pristine nonacene, the electronegative nitrogen atoms lower the frontier orbitals, resulting in an increased STS transport gap of 1.49 eV. Furthermore, the formation of four pyridine-like rings induces a stronger modulation of the aromaticity in tetraazanonacene compared to substitution patterns where nitrogen atoms form pyrazine-like rings. This observation is different from the nucleus independent chemical shift investigation of previous reported tetraazaundecacene, for which a stronger open-shell character is expected. Our work provides access to the synthesis of extended azaacenes and to an understanding of their properties.}, archive = {J_ANGEW}, author = {Zilin Ruan and Liping Ye and Yogendra Singh and Tim Naumann and Faming Kang and Ye Liu and Michael Mastalerz and J. Michael Gottfried}, doi = {10.1002/anie.202504707}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202504707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-surface synthesis and characterization of tetraazanonacene}, volume = {64}, year = {2025}, }
• (2025). Scalable and practical electrooxidation of electron-deficient methylarenes to access aromatic aldehydes. ANGEW, 64(33), e202504612. (www)

  @article{ , abstract = {Aromatic aldehydes are pivotal synthetic intermediates with applications in fine chemicals, pharmaceuticals, agrochemicals, and advanced materials. Although the oxidation of methylarenes represents an ideal route to aromatic aldehydes due to the availability of starting materials, existing methods face significant challenges, including reliance on hazardous oxidants, costly catalysts, poor scalability, and limited compatibility with electron-deficient substrates. To address these limitations, we report a practical and scalable electrochemical method for the oxidation of electron-deficient methylarenes to access aromatic aldehydes, eliminating the need for chemical oxidants or homogeneous transition-metal catalysts. This approach operates under industrially viable conditions—high current densities (75 mA cm⁻ 2 ), minimal electrolyte loading (0.05 equiv), and operation in an undivided cell without additives—to produce aromatic acetals, which are readily hydrolyzed to the corresponding aldehydes. The use of minimal electrolyte not only reduces costs and simplifies product isolation but also significantly enhances anodic oxidation selectivity, ensuring high efficiency and practicality. This protocol exhibits a broad substrate scope, compatibility with both batch and continuous flow systems, and exceptional scalability, as demonstrated by successful kilogram-scale synthesis.}, archive = {J_ANGEW}, author = {Chong Huang and Hai-Chao Xu}, doi = {10.1002/anie.202504612}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202504612}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable and practical electrooxidation of electron-deficient methylarenes to access aromatic aldehydes}, volume = {64}, year = {2025}, }
• (2025). A bidirectional ion kinetic regulator suppressing lithium dendrites in advanced lithium-sulfur batteries. ANGEW, 64(33), e202504398. (www)

  @article{ , abstract = {Liquid organic electrolytes (LOEs) are of crucial significance in secondary battery deposition processes. Based on Sand's time formula, this study proposes a novel bidirectional ion kinetic regulator concept. Verified in lithium-sulfur batteries (LSBs), it is demonstrated that regulating the migration of anions and cations simultaneously can effectively promote the realization of dendrite-free batteries. This bidirectional ion kinetic regulator forms octahedral complexes with TFSI − , decreasing TFSI − migration, enhancing Li + desolvation and diffusion, and thus extending the dendrite formation time by over 25 times. Moreover, the attraction of the regulator towards solvent molecules and its improvement on the sulfur reduction kinetics effectively suppress the shuttle effect. Subsequently, the assembled Li||Li (1 mA cm −2 for 2000 h), Li-Cu (99.4% of CE), and Li-S (1000 cycles at 4 C) cells deliver extremely excellent cycling stability. An Ah-level Li-S pouch cell also exhibits negligible capacity decay (50 cycles without capacity decay). This confirms the importance of regulating both anions and cations for high-safety LSBs.}, archive = {J_ANGEW}, author = {Jun Jiang and Yanwen Ding and Shujun Liu and Zhijie Qi and Tong Guo and Zhihua Wang and Jingwen Sun and He Zhu and Xiaoping Ouyang and Xin Wang and Junwu Zhu and Yongsheng Fu}, doi = {10.1002/anie.202504398}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202504398}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bidirectional ion kinetic regulator suppressing lithium dendrites in advanced lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Step test for rapid screening of material and process parameters for resin development in DLP 3D printing. ANGEW, 64(33), e202504154. (www)

  @article{ , abstract = {The success of 3D printing based on vat polymerization by spatially controlled UV light exposure strongly depends on appropriate resins. However, in search of new resins, optimizing a resin's composition as well as its printing parameters can be time-consuming and labor-intensive. To address these challenges, we present a rapid parameter screening that enables efficient evaluation of 24 printing parameter settings within one print focusing on exposure energy, exposure time, and layer thickness as the most crucial process parameters in 3D printing based on digital light processing (DLP). Our step test minimizes the required number of experimental iterations and 3D prints by relying on optical characterization without the need for special analytical devices, making it rapid and accessible for a broad range of users across different disciplines. For a proof of concept, the step test is applied to define optimal printing parameters of three commercial resins and evaluate the polymerization efficiency of two predominantly biobased, noncommercial resins containing either phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide or curcumin as photoinitiators. With that, we introduce a straightforward test that is easy to implement and adaptable to other UV polymerization-based printing methods, speeding up the time from resin screening to optimal printing parameters and products.}, archive = {J_ANGEW}, author = {Michelle Vigogne and Cosima Aeschbach and Ricardo Bernhardt and Anika Kaufmann and Julian Thiele}, doi = {10.1002/anie.202504154}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202504154}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Step test for rapid screening of material and process parameters for resin development in DLP 3D printing}, volume = {64}, year = {2025}, }
• (2025). Mechanoactivated celite as a catalyst for C‒H bond perfluoroalkylation and other radical reactions. ANGEW, 64(33), e202504137. (www)

  @article{ , abstract = {Herein, we report that Celite (diatomaceous earth) commonly viewed as an innocent filter aid or support material, or Earth-abundant, non-toxic metal oxides are efficient mechanoactivated catalysts for arene and heteroarene C─H bond radical trifluoromethylation and pentafluoroethylation, with the activity comparable with previously reported mechanochemical methods utilizing piezoelectric materials. Celite was also applied for mechanochemical dibromination of a double bond with N-bromosuccinimide, eliminating the need to use of lithium titanate as a piezoelectric mechanoredox catalyst. Mechanoactivation via ball milling in the presence of minimal amount of solvent was crucial to observe the reactivity, while sonication or using a pre-ground suspension in a bulk solvent were not efficient. The EDX studies and comparison with individual metal oxides suggest a possible role of trace metal oxides in mechanoinduced reactivity. Celite could be recycled and reused several times without significant loss of activity. This approach offers environmentally benign, biocompatible and inexpensive nature-inspired materials as efficient mechanocatalyts and conceptually broadens the scope of mechanoactivated solids to the materials previously deemed inert.}, archive = {J_ANGEW}, author = {Thomas J. Hasiweder and Hoan M. Dinh and Dilip K. Pandey and Aleksandr Sorvanov and Julia R. Khusnutdinova}, doi = {10.1002/anie.202504137}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202504137}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanoactivated celite as a catalyst for C‒H bond perfluoroalkylation and other radical reactions}, volume = {64}, year = {2025}, }
• (2025). Electrolytes with tailored Solvent–Solvent interactions for flame-retardant stable sodium-metal batteries.. ANGEW, 64(33), e202503864. (www)

  @article{ , abstract = {Sodium metal batteries (SMBs), which possess abundant sodium resources and high energy density, have attracted widespread attention. However, the continuous reaction between the electrolyte and the sodium metal anode, along with the formation of an unstable solid electrolyte interphase (SEI), leads to rapid capacity decay and the safety hazard of potential ignition. In this work, designing a low-cost and flame-retardant electrolyte with solvent–solvent interactions is achieved by introducing sodium-difluoro(oxalato)borate (NaDFOB) as a single salt into the ester-based electrolyte on the basis of trimethyl phosphate. Theoretical research combined with experimental study disclose through the solvent–solvent interactions, an ion-aggregate-rich solvation structure is formed at low concentrations, leading to the formation of a gradient SEI enriched with inorganic compounds such as B and F on the anode. This effectively suppresses interfacial reactions and sodium dendrite growth, significantly improving the cycling stability along with the optimizing the safety of SMBs. The Na||Na 3 V 2 (PO 4 ) 3 battery using this electrolyte maintains a high-capacity retention of 93% after 5000 cycles (320 days) at 1C. This approach provides a reliable solution for the application of flame-retardant electrolytes in SMBs, which also sheds light on the designing principle of advanced battery systems.}, archive = {J_ANGEW}, author = {Zhangbin Cheng and Zehui Zhang and Mingtian Wu and Min Jia and Xinyi Du and Zheng Gao and Shuai Tong and Tao Wang and Xiaohong Yan and Xiaoyu Zhang and Haoshen Zhou}, doi = {10.1002/anie.202503864}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202503864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolytes with tailored Solvent–Solvent interactions for flame-retardant stable sodium-metal batteries.}, volume = {64}, year = {2025}, }
• (2025). Self-driven seeding, acid stalling, and solidifying: Time-resolved mapping of nonclassical pathways in Metal–Organic gel assembly. ANGEW, 64(33), e202503855. (www)

  @article{ , abstract = {Metal-organic gels (MOGs), an innovative subset of metal-organic frameworks (MOFs), feature hierarchically porous architecture and self-shaping monolithic morphologies, demonstrating them significantly potential for advanced applications in catalysis, gas storage, and energy conversion. Despite their functional versatility, the synthesis of MOGs remains empirical, as the actual formation mechanisms are largely unexplored. Here, a multiscale characterization strategy integrating time-resolved in-situ small-angle X-ray scattering (SAXS), Zr K-edge X-ray absorption fine structure (XAFS), and attenuated total reflectance Fourier-transform infrared (ATR-FTIR) analyses are systematically employed to elucidate the formation mechanism of UiO-66(Zr) gel. The synthetic techniques provide a multidimensional perspective: (1) At the mesoscale, self-induced heterogeneous nucleation triggers a rapid evolution from linear prenucleation clusters to a 3D fractal network governed by autocatalytic hydrolysis of Zr precursors. (2) At the atomic level, the reorganization of Zr–oxo clusters and the substitution of coordinating H 2 O molecules and chloride ions with terephthalate ligands over prolonged timescales are uncovered. Crucially, in-situ generated acid-mediated coordination suppression emerges as a pivotal factor preventing the conversion of MOGs into their crystalline MOF counterparts. These findings highlight a nonclassical evolution pathways distinct from classical MOF crystallization, thereby providing a mechanistic foundation for tailoring MOGs with programmable morphological and structural attributes.}, archive = {J_ANGEW}, author = {Ziqi Wang and Kun Qian and Lina He and Hailong Huang and Yifan Gu and Fengting Li and Jianrong Zeng and Yi-nan Wu}, doi = {10.1002/anie.202503855}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202503855}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-driven seeding, acid stalling, and solidifying: Time-resolved mapping of nonclassical pathways in Metal–Organic gel assembly}, volume = {64}, year = {2025}, }
• (2025). Intriguing reactivity of a 1,2-dihydrodialumane towards organic azides – From a terminal Diazido–Dialumane to pendulum-clock-like azide bridging. ANGEW, 64(33), e202503638. (www)

  @article{ , abstract = {The reactivity of dihydro-dialane with organic azides is described. Treatment of the hybrid ligand-based dialane [(DNI{H}Al) 2 ] ( I ) (DNI = [3,3-dimethyl-2-2-methyl-2-(2,6-diisopropylaniline)ethenyl]-3H-indolenine) with TMSN 3 (TMS = trimethylsilyl) at room temperature gives the first diazido-dialane [(DNI{N 3 }Al) 2 ] ( 1 ). The transformation from here to a more stable aluminium-tetrazole [DNIAl(NTMS) 2 N 2 ] ( 2 ) is established. The reaction of other RN 3 gives [(DNI{H}Al) 2 (κ 2 -N 3 R)] (R = Benzyl in 3 and 1-Adamantyl in 4 ) with the azide in a μ-bridging position between two aluminium atoms. Using 1 H NOESY/EXSY NMR spectroscopy, a positional exchange of the two TMS groups ( 2 ) via rotation of the tetrazole unit is observed. In contrast, compound 3 exhibits a pendulum-clock-like dynamic, with N α oscillating between the two aluminium atoms in solution. The reaction of dialane I with DippN 3 (Dipp = 2,6- i Pr 2 -C 6 H 3 ) gives the dialuminium amine [{DNI(H)Al} 2 (μ-NDipp)] ( 5 ).}, archive = {J_ANGEW}, author = {Xiaobai Wang and Franziska Traeger and Raphael F. Ligorio and Nico Graw and Regine Herbst-Irmer and Anna Krawczuk and Malte Fischer and Dietmar Stalke}, doi = {10.1002/anie.202503638}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202503638}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intriguing reactivity of a 1,2-dihydrodialumane towards organic azides – From a terminal Diazido–Dialumane to pendulum-clock-like azide bridging}, volume = {64}, year = {2025}, }
• (2025). Near-infrared biosensing of drug-induced cell-heterogeneous injuries with an ultrahigh turn-on ratio. ANGEW, 64(33), e202503579. (www)

  @article{ , abstract = {Fluorescence probes of reactive oxygen species in the near-infrared (NIR) spectral region, i.e., 800 nm and beyond, are desired for in vivo biosensing, diagnosis, and pharmacology. However, the NIR dyes are typically prone to oxidative destruction, and the probes based on these dyes exhibit a poor fluorescence turn-on ratio and a low detection sensitivity. EC5 is a bright and stable NIR fluorochromic scaffold and yet has not been exploited for probe design. Despite the structural analogy of EC5 to xanthene dyes, the classic spiro-cyclization at the central methine carbon was surprisingly not applicable to EC5 . Here, we report the rational development of a novel probe design strategy for EC5 dye, i.e., asymmetric conjugative addition at the quinone-methide carbon. EC5 - H3 via this approach is a robust probe for highly oxidative species. Its merits include an ultrahigh turn-on ratio of ca. 200-fold and high resistance of the detection product toward ONOO − -mediated destruction. The feasibility of EC5 - H3 for practical applications was showcased by in vivo biosensing of drug-induced oxidative injuries to the liver. The high turn-on ratio and high brightness of the probe allow tissue injuries to be imaged with confocal microscopy to reveal the heterogeneity in oxidative injuries to different liver cells.}, archive = {J_ANGEW}, author = {Xinru Hu and Cheng Yao and Baosheng Wang and Yuyang Zhang and Jinwen Yang and Yan Dong and Yi Li and Danyang Wang and Xiaohua Chen and Yanyan Deng and Guangbo Ge and Ben Zhou and Xiao Luo and Xuhong Qian and Youjun Yang}, doi = {10.1002/anie.202503579}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202503579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared biosensing of drug-induced cell-heterogeneous injuries with an ultrahigh turn-on ratio}, volume = {64}, year = {2025}, }
• (2025). Modular synchronous synthesis of amides and α-ketoamides realized by matching electrolysis-paired tandems. ANGEW, 64(33), e202503440. (www)

  @article{ , abstract = {Feasible electrolysis-paired tandem synthesis represents an elaborately organized and high-efficiency strategy balancing energy consumption and value-added synthesis. Herein, we developed an exotic electrolysis-paired tandem synthesis system driven by a metalloenzyme-like bifunctional single-molecular heterostructure catalyst (MimNiPc/CNT), which enables the modular synchronous synthesis of amides and α-ketoamides through cathodic CO-relayed aminocarbonylation and anodic iodine (I 2 )-mediated keto-amidation tandem reactions, respectively. Notably, the established MimNiPc/CNT is not only effective for parallel electrolysis-paired tandem reactions with various substrates but also adaptable for both divergent and sequential electrolysis-paired tandem reactions, producing value-added amide and α-ketoamide compounds with isolated yields up to ∼90%. Detailed isotope labeling and mass spectrometry tracking experiments meticulously unveiled the reaction mechanisms, the processes at both electrodes can be refined into sequential electrocatalysis and chemocatalysis steps. Our work also demonstrates the flexibility and scalability of this “two birds with one stone” synthetic protocol, providing an experimental reference for precise synthesis.}, archive = {J_ANGEW}, author = {Qing Li and Dong-Dong Ma and Jianqiang Zhao and Wenbo Wei and Shu-Guo Han and Xin-Tao Wu and Ruqiang Zou and Qiang Xu and Qi-Long Zhu}, doi = {10.1002/anie.202503440}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202503440}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular synchronous synthesis of amides and α-ketoamides realized by matching electrolysis-paired tandems}, volume = {64}, year = {2025}, }
• (2025). Corrosion of calcium metal in Ca(TFSI)2/DMAc electrolyte and its solution via alloy interface and competitive solvation. ANGEW, 64(33), e202502729. (www)

  @article{ , abstract = {Calcium metal batteries (CMBs) are promising for large-scale energy storage due to calcium‘s abundance and high theoretical capacity, but hindered by poor compatibility between electrolyte and calcium metal. Here, we unveil two corrosion types of calcium in calcium bis(trifluoromethanesulfonimide)/dimethylacetamide [Ca(TFSI) 2 /DMAc] electrolytes: native passivation from solvent reduction during aging and electrochemical corrosion from anion decomposition. The native passivation layer aggravates the electrochemical corrosion by the decomposition of TFSI − to the large grain Ca 2+ -insulator CaF 2 , leading to the calcium metal failure. We introduce a bifunctional SnI 2 electrolyte additive to simultaneously mitigate both corrosions. Sn 2+ facilitate the spontaneous galvanic replacement reaction to form the Ca-Sn alloy, inhibiting native passivation, while I − replace TFSI − to participate in the Ca 2+ primary solvation shell and prevent the electrochemical TFSI − decomposition. By taking advantage of those features above, over 500 h of stable cycling with a reduced overpotential of 0.33 V at 0.1 mA cm −2 and 0.1 mAh cm −2 was achieved, outperforming state-of-the-art Ca(TFSI) 2 -based electrolytes. Our work provides a fundamental understanding of corrosion at calcium metal surface and will guide suitable electrolyte design for anti-corrosion in metal batteries.}, archive = {J_ANGEW}, author = {Jiang Liang and Min Wang and Shaohua Zhu and Dongyao Zhu and Rui Wang and Jiajing Wang and Lianmeng Cui and Meng Huang and Wenwei Zhang and Qinyou An and Lei Zhang and Kangning Zhao}, doi = {10.1002/anie.202502729}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202502729}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Corrosion of calcium metal in Ca(TFSI)2/DMAc electrolyte and its solution via alloy interface and competitive solvation}, volume = {64}, year = {2025}, }
• (2025). Coordinative ring-opening polymerization of limonene carbamate toward phosgene- and isocyanate-free polyurethane. ANGEW, 64(33), e202502727. (www)

  @article{ , abstract = {This study presents a phosgene- and isocyanate-free route for the synthesis of polyurethanes using ( R )-limonene as a bio-based starting material. The synthesis of the cyclic limonene-based carbamate monomer LU is achieved in high yields using dimethyl carbonate as a sustainable, less hazardous phosgene surrogate and is verified by NMR, SC-XRD, ESI-MS, GC-MS, and elemental analysis. Polymerizations were carried out by coordinative ring-opening polymerization. Sn(Oct) 2 showed the best catalytic performance, achieving up to 93% conversion with molecular weights up to 16.0 kg mol −1 at a polydispersity of 1.5. Detailed mechanistic insights were obtained by kinetic studies, end group determination via ESI-MS and stoichiometric ninhydrin experiments, N – H methylation of LU , kinetic isotope experiments, and 119 Sn NMR measurements. The resulting semi-crystalline polyurethane exhibits promising thermal properties, including a decomposition temperature of 252 °C and a glass transition temperature above 150 °C. Depolymerization in solution was achieved in high yield using the same catalyst. This work describes a coordinative ring-opening polymerization approach using a terpene-based carbamate as monomer, an important step toward bio-based polyurethanes.}, archive = {J_ANGEW}, author = {Jonas Futter and Leon F. Richter and Stefanie Hörl and Moritz Kränzlein and Bernhard Rieger}, doi = {10.1002/anie.202502727}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202502727}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coordinative ring-opening polymerization of limonene carbamate toward phosgene- and isocyanate-free polyurethane}, volume = {64}, year = {2025}, }
• (2025). Redox-driven in situ formation of bimetallic catalysts via Sn2+/Sn4+ interconversion. ANGEW, 64(33), e202502118. (www)

  @article{ , abstract = {Bimetallic catalysts have garnered substantial interest across diverse fields due to their distinctive geometric and electronic structures. Nevertheless, achieving uniformly distributed bimetallic catalysts remains challenging due to the solubility or charge properties of ions in specific bimetallic systems. Herein, we present an innovative in situ redox-driven synthesis strategy utilizing Sn 2+ /Sn 4+ interconversion to address these challenges. By immobilizing Sn 2+ ions on Al-deficient alumina and capturing secondary metal ions through redox reactions, we successfully synthesized eight distinct Sn–M bimetallic catalysts. The representative Sn–Pt catalysts derived from [PtCl 4 ] 2− or [Pt(NH 3 ) 4 ] 2+ ions, lead to the reduction of Pt 2+ to Pt 0 with analogous local structures, resulting in comparable catalytic performance in carbon monoxide oxidation and propane dehydrogenation. This redox-driven synthesis strategy can be extended to other bimetallic systems, with promising preliminary results observed in Cr–M systems. This innovative strategy effectively mitigates the hydrolysis of tin ions, neutralizes the influence of ion charges, and addresses the solubility challenges of secondary metal ions, providing a robust solution for the design of bimetallic catalysts.}, archive = {J_ANGEW}, author = {Panpan Li and Yongbin Yao and Wenhui Zhong and Wangliang Li and Qing Zhu and Xi Wang and Jun Jiang}, doi = {10.1002/anie.202502118}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202502118}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-driven in situ formation of bimetallic catalysts via Sn2+/Sn4+ interconversion}, volume = {64}, year = {2025}, }
• (2025). Complex donuts: Small variations in DNA sequence dictate pathway complexity in DNA nanotoroids. ANGEW, 64(33), e202501441. (www)

  @article{ , abstract = {The formation of higher-order structures in natural biopolymers, such as polypeptides and nucleic acids, is governed by sequence specificity and monomer chemistry. Although nucleic acids can assemble into programmable nanostructures through base-pairing interactions, their chemical diversity is limited to four nucleobases. DNA amphiphiles overcome this limitation by introducing orthogonal interactions through non-nucleosidic modifications. These amphiphiles self-assemble into diverse morphologies, such as spheres, fibers, or sheets, with closely packed, parallel DNA strands on their exterior. This unusual arrangement can give rise to emergent properties absent in simple DNA strands. Here, we show that the precise sequence of single-stranded DNA, independent of double helix base-pairing, can be used to program the self-assembled morphology of DNA amphiphiles. Remarkably, small sequence variations can drive the formation of nonequilibrium DNA nanotoroids, rather than conventional morphologies. The DNA nanotoroids were formed as on-pathway structures via a competitive mechanism, only when a toroid-selective DNA sequence was used. They could be stabilized noncovalently by a small molecule cross-linker or coassembly with a secondary DNA amphiphile. Molecular dynamics simulations demonstrated the dependence of toroid formation on the structure of the end π-stacking unit. This work introduces a new class of DNA-based nanotoroid materials with assembly properties controlled by unique sequences, akin to proteins, for applications in cell delivery, nanofiltration, nanoreactors, and materials templation.}, archive = {J_ANGEW}, author = {Muhammad Ghufran Rafique and Yihao Wu and Yutong Shi and Quentin Laurent and Abdelrahman Elmanzalawy and Christopher Saab and Yu Shi and Dmytro F. Perepichka and Jianing Li and Hanadi F. Sleiman}, doi = {10.1002/anie.202501441}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202501441}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Complex donuts: Small variations in DNA sequence dictate pathway complexity in DNA nanotoroids}, volume = {64}, year = {2025}, }
• (2025). Regioselective hydrocyanation of internal alkynes enabled by a transition-metal-free dual-catalytic system. ANGEW, 64(33), e202500940. (www)

  @article{ , abstract = {Since its discovery in 1954, the hydrocyanation of multiple carbon-carbon bonds has emerged as a powerful strategy for the synthesis of nitriles. However, the elusive control of selectivity and typical reliance on expensive and toxic transition metal (TM) based catalysts significantly hinder the utility of this process. Here, we report an exclusively regioselective hydrocyanation of unbiased alkynes, driven by base-catalyzed reversible alkyne-allene isomerization and phosphine-catalyzed HCN transfer to the allene. This TM-free, dual-catalytic approach introduces a novel mode of selectivity control via regioselective hydrocyanation of the allene intermediate. The methodology secures a cost-effective access to a broad range of vinyl nitriles (40 examples) with yields up to 97% and Z/E stereoselectivity up to 20:1, including complex natural product derivatives. A comparison with TM-based systems highlighted a 2500-fold cost reduction, as well as the elimination of the troublesome separation of the regioisomers. Mechanistic studies elucidated the reaction pathway, shedding light on the achieved regioselectivity. By altering one catalyst in a dual-catalytic system, we demonstrated the regioselectivity switch, thereby facilitating regiodivergent hydrocyanation (eight examples). In a broader context, this approach offers a foundation for developing the next generation of TM-free strategies for the regioselective hydrofunctionalizations of unbiased alkynes.}, archive = {J_ANGEW}, author = {Aleksandra Zasada and Dawid Lichosyt}, doi = {10.1002/anie.202500940}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202500940}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioselective hydrocyanation of internal alkynes enabled by a transition-metal-free dual-catalytic system}, volume = {64}, year = {2025}, }
• (2025). Realizing persistent lithium protection and revival with dissolution-equilibrium-driven sustainable additives reservoir. ANGEW, 64(33), e202500135. (www)

  @article{ , abstract = {Additive chemistry plays a pivotal role in enhancing the cycling stability of lithium metal batteries. Conventional additives with high solubility facilitate the formation of a stable interface in the early stages of cycling, yet typically act as “sacrificial agents”, failing to maintain a durable interface over long time. Herein, we demonstrate a sustainable lithium protection and retrieval strategy based on additive reservoirs driven by chemical dissolution equilibrium. A sparingly soluble AgI coating on the separator provides a continuous supply of constant concentration of Ag + and I − , where Ag + contributes to the formation of a Li–Ag alloy interphase, promoting uniform Li deposition, while I − assisting in the recovery of inactive Li. With this strategy, symmetric Li||Li batteries deliver an extended cycle life over of 1000 h at 5 mA cm −2 with a capacity of 5 mAh cm −2 . Additionally, practical pouch cells demonstrate a prolonged cycle life of over 200 cycles with 82% capacity retention. This work offers new insights into additive chemistry and paves the way for the development of durable lithium metal batteries.}, archive = {J_ANGEW}, author = {Xiao-Xi Luo and Shuang-Jie Tan and Juan Zhang and Jun-Chen Guo and Chao-Hui Zhang and Yu-Hao Wang and Wan-Li Wang and Jian-Song Wu and Xing-Long Wu and Yu-Guo Guo}, doi = {10.1002/anie.202500135}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202500135}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Realizing persistent lithium protection and revival with dissolution-equilibrium-driven sustainable additives reservoir}, volume = {64}, year = {2025}, }
• (2025). An immobilized rh-based solid molecular catalyst for the reductive hydroformylation of 1-octene. ANGEW, 64(33), e202424144. (www)

  @article{ , abstract = {The reductive hydroformylation of olefins is an important process in the chemical industry to produce alcohols directly without isolating the aldehydes as intermediates. As the hydroformylation is a homogeneously catalyzed reaction, the catalyst recycling and down-stream processing is often complex and energy intensive. A heterogeneous reductive hydroformylation catalyst was developed in this work by immobilizing Rh on polymeric amine macroligands to form solid molecular catalysts (SMCs). An iterative macroligand improvement was carried out by increasing the basicity and number of amine groups at the immobilization sites. With the best performing SMC, olefins were fully converted to >99% alcohols without a hydrogenation of the substrate in a solvent free environment, thus requiring only a separation of the heterogeneous catalyst to yield the pure product. The catalyst was successfully recycled over 12 runs with a perpetual Rh leaching as low as 1.2%, and the metal to macroligand ratio was identified as most important parameter in reducing metal loss.}, archive = {J_ANGEW}, author = {Keanu V. A. Birkelbach and Jeroen T. Vossen and Thorsten Rösler and Isabella Kappel and Ansgar Meise and Marc Heggen and Andreas J. Vorholt and Regina Palkovits}, doi = {10.1002/anie.202424144}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202424144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An immobilized rh-based solid molecular catalyst for the reductive hydroformylation of 1-octene}, volume = {64}, year = {2025}, }
• (2025). Boosting CO2 fixation into dimethyl carbonate via multiple active sites constituted by VO-ce-O vacancy clusters on single-unit-cell CeO2 nano-sheets. ANGEW, 64(33), e202423958. (www)

  @article{ , abstract = {The thermodynamic stability and intrinsic kinetic inertia of CO 2 present a critical challenge for its effective activation in the synthesis of high-value dimethyl carbonate (DMC). In this work, we report the fabrication of novel O-Ce-O vacancy clusters (V O-Ce-O ) incorporated into CeO 2 nano-sheets with a near single-unit-cell thickness to construct atomically adjacent multiple active sites on their surfaces. These active sites significantly enhance the activation of both CO 2 and CH 3 OH. Impressively, the as-prepared CeO 2 with V O-Ce-O catalyst exhibits an excellent DMC yield of 31.2 mmol g −1 , surpassing previously reported Ce-based catalysts under equivalent reaction conditions. Experimental results and theoretical calculations reveal that oxygen vacancy increases the reducibility of lattice oxygen, facilitating CO 2 activation, while cerium vacancies weaken the *CH 3 O adsorption, promoting the coupling reaction between *CH 3 O and *CO 2 to form the intermediate (*CH 3 OC(O) 2 ). Notably, the formation of vacancy clusters reduces the energy barrier for the rate-controlled step (*CH 3 OC(O) 2 dissociation to *CH 3 OCO), thereby boosting the DMC yield. Our new findings provide valuable insights into surface engineering and active site modulation of cerium-based catalysts, offering a viable pathway for green resource utilization of CO 2 .}, archive = {J_ANGEW}, author = {Xiushuai Guan and Xiaokun Wang and Xiaochao Zhang and Changming Zhang and Steven S. C. Chuang and Zhong Li}, doi = {10.1002/anie.202423958}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {33}, pages = {e202423958}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting CO2 fixation into dimethyl carbonate via multiple active sites constituted by VO-ce-O vacancy clusters on single-unit-cell CeO2 nano-sheets}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Molecular design and synthesis of narrowband near-ultraviolet and pure deep-blue thermally activated delayed fluorescence materials by an ether group strategy. ANGEW, 64(32), e202583202. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583202}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202583202}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Molecular design and synthesis of narrowband near-ultraviolet and pure deep-blue thermally activated delayed fluorescence materials by an ether group strategy}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Mechanism of first proton-coupled electron transfer of water oxidation at the BiVO4–Water interface. ANGEW, 64(32), e202583201. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583201}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202583201}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Mechanism of first proton-coupled electron transfer of water oxidation at the BiVO4–Water interface}, volume = {64}, year = {2025}, }
• (2025). Anion vacancies triggered spin polarization enables efficient piezocatalysis for water cleanup (Angew. chem. int. ed. 32/2025). ANGEW, 64(32), e202514872. (www)

  @article{ , archive = {J_ANGEW}, author = {Qiang Zhong and Yue Sun and Shao-Gui Yang and Chen-Min Xu and Zhao-Qing Liu and Kan Zhang and Shi-Cheng Yan and Huan He}, doi = {10.1002/anie.202514872}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202514872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion vacancies triggered spin polarization enables efficient piezocatalysis for water cleanup (Angew. chem. int. ed. 32/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Elucidating the correlation between the redox potential, spin state and crystal structure in a series of ferrous complexes with redox-active ligands (Angew. chem. int. ed. 32/2025). ANGEW, 64(32), e202514870. (www)

  @article{ , archive = {J_ANGEW}, author = {Saioa Cobo and Livia Getzner and Yasmine Remili and Zakaria Ziani and Laure Vendier and William Nicolazzi and Aurelian Rotaru and Haizhu Yu and Gabor Molnar and Azzedine Bousseksou}, doi = {10.1002/anie.202514870}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202514870}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Elucidating the correlation between the redox potential, spin state and crystal structure in a series of ferrous complexes with redox-active ligands (Angew. chem. int. ed. 32/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Origin of room temperature methanol synthesis over hcp-PdMo (Angew. chem. int. ed. 32/2025). ANGEW, 64(32), e202514568. (www)

  @article{ , archive = {J_ANGEW}, author = {Feilong Xing and Ruopeng Wang and Shiyao Wang and Hironobu Sugiyama and Chenyang Zhu and Masayoshi Miyazaki and Hideo Hosono and Masaaki Kitano}, doi = {10.1002/anie.202514568}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202514568}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Origin of room temperature methanol synthesis over hcp-PdMo (Angew. chem. int. ed. 32/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Engineering a meltable MOF to tune liquid transition and promote coenzyme regeneration (Angew. chem. int. ed. 32/2025). ANGEW, 64(32), e202514524. (www)

  @article{ , archive = {J_ANGEW}, author = {Wengang Huang and Wen-Long Xue and Peng Chen and Zhiliang Wang and Rijia Lin and Shuke Zhao and Shuwen Yu and Yuelei Chen and Xiangyi Zha and Dominique Appadoo and Tian Tian and Vicki Chen and Sebastian Henke and Anthony K. Cheetham and Lianzhou Wang and Jingwei Hou}, doi = {10.1002/anie.202514524}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202514524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Engineering a meltable MOF to tune liquid transition and promote coenzyme regeneration (Angew. chem. int. ed. 32/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Fragment discovery by X-ray crystallographic screening targeting the CTP binding site of pseudomonas aeruginosa IspD”. ANGEW, 64(32), e202514238. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202514238}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202514238}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Fragment discovery by X-ray crystallographic screening targeting the CTP binding site of pseudomonas aeruginosa IspD”}, volume = {64}, year = {2025}, }
• (2025). Twist-promoted photoredox catalysis in metal-organic framework for defluorination reactions. ANGEW, 64(32), e202511396. (www)

  @article{ , abstract = {The relatively short excited-state lifetime is one main drawback of organic photosensitizers, resulting in their restricted catalytic capability and high catalyst loadings. We herein report the design of a twisted ligand N 9 ,N 9 ,N 10 ,N 10 -tetrakis[(1,1′-biphenyl)-4-carboxylic acid]-9,10-anthracene diamine (H 4 TCPDA). Its twisted geometry significantly elongates the lifetime of charge-transfer state as substantiated by detailed ultrafast transient absorption (TA) spectroscopic and electrochemical studies. Moreover, its rigid structure benefits the formation of highly crystalline Y-TCPDA metal-organic frameworks (MOFs) with excellent stability toward F − solutions. Therefore, Y-TCPDA competently catalyzes chemoselective defluorinative modifications, a challenge remained in MOF catalysis, and olefin reductive cross-coupling with high turnover numbers of up to 9000. Control experiments underscore the protection of organic photocatalytic centers by the MOF platform, while similar organic catalysts are found to be decomposed in a homogeneous catalytic system.}, archive = {J_ANGEW}, author = {Zhiyi Yang and Chao Li and Peiqi Zhang and Jiaxin Lin and Jiayue Tang and Cheng-Yong Su and Teng-Teng Chen and Yangjian Quan}, doi = {10.1002/anie.202511396}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202511396}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Twist-promoted photoredox catalysis in metal-organic framework for defluorination reactions}, volume = {64}, year = {2025}, }
• (2025). Unlocking ultrafast-kinetics asymmetric heterojunction with multi-anionic redox chemistry enables high Energy/Power density and low-temperature zinc-ion batteries. ANGEW, 64(32), e202510907. (www)

  @article{ , abstract = {The development of high-performance Zn-ion batteries is hindered by sluggish reaction kinetics and inadequate redox activity in conventional vanadium-based cathodes. Herein, a thermal oxidation phase-engineering strategy is proposed to construct a comprising VSSe core and oxygen-enriched VO 2 and V 2 O 5 interfaces triple-phase heterojunction cathode. This unique architecture leverages a significantly increased specific surface area, which facilitates rapid electrode–electrolyte interactions and boosts pseudocapacitive contributions. This integrated structure, featuring optimized coordination environments and interfaces, promotes synergistic multi-anionic (S/Se/O) and cationic (V) redox activity and facilitates efficient charge transfer across the interfaces, overcoming intrinsic limitations of capacity and structural instability often observed in single-phase materials, especially during prolonged cycling. This optimized cathode achieves a record-high reversible capacity of 432 mAh g −1 at 1 A g −1 , surpassing mild-oxidized and over-oxidized VSSe counterparts. Remarkably, it retains 80% capacity after 14 000 cycles at 30 A g −1 under cryogenic conditions of −10 °C, demonstrating unprecedented low-temperature durability. The structure–function relationship of heterojunction is driven by enhanced p–d orbital hybridization and spin polarization effects at the heterointerfaces, contributing to the improved redox activity and kinetics. This work establishes a design paradigm for engineering multi-phase heterojunction electrodes with tailored surface area and interfacial properties for next-generation energy storage systems.}, archive = {J_ANGEW}, author = {Ming Yang and Yuru Lin and Peiwei Chen and Mengnan Lai and Jianhui Zhu and Guomin Li and Minfeng Chen and Yanyi Wang and Mingyan Chuai and Jizhang Chen and Guoliang Chai and Hongwei Mi and Lingna Sun and Chuanxin He and Dingtao Ma and Peixin Zhang}, doi = {10.1002/anie.202510907}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510907}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking ultrafast-kinetics asymmetric heterojunction with multi-anionic redox chemistry enables high Energy/Power density and low-temperature zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Molecular design and synthesis of narrowband near-ultraviolet and pure deep-blue thermally activated delayed fluorescence materials by an ether group strategy. ANGEW, 64(32), e202510891. (www)

  @article{ , abstract = {Boron-containing polycyclic aromatic hydrocarbons are promising materials for the development of displays due to their multiple-resonance thermally activated delayed fluorescence (MR-TADF) with narrowband emission. However, except for electrophilic aromatic borylation reactions, synthetic strategies for the generation of boron-containing MR-TADF molecules remain virtually unexplored. In particular, the synthesis of MR-TADF emitters that exhibit narrow near-ultraviolet and pure deep-blue emission constitutes a challenging task. Here, we present a directed tri- ortho -lithiation–borylation approach that provides a new family of N , N -bridge-type triphenylboranes that bear phenylimino groups instead of the methylene groups at the 8- and 14-positions and ether groups instead of the hydrogen atoms at the 3- and 19-positions of 1-borapentacyclohenicosanonaene. The effects of the electron-donating resonance of the oxygen atoms of the ether groups and the incorporation of oxygen atoms in the six-membered cycle allow the precise tuning of the HOMO–LUMO energy gaps, resulting in narrowband near-ultraviolet and pure deep-blue TADF with Commission-International-de-l’Éclairage coordinates (CIE x , y ) of (0.142–0.160, 0.029–0.063) for the photoluminescence (PL) and (0.146–0.160, 0.026–0.053) for the electroluminescence (EL). The CIE x , y for the EL meet the BT.2020 requirement for the blue primary of ultrahigh-definition displays.}, archive = {J_ANGEW}, author = {Yuichi Kitamoto and Atsuya Ogawa and Masaya Inakawa and Yutaka Fujimoto and Masanori Koshimizu and Kazuma Oda and Hideo Taka and Hiroshi Kita and Tetsutaro Hattori}, doi = {10.1002/anie.202510891}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510891}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular design and synthesis of narrowband near-ultraviolet and pure deep-blue thermally activated delayed fluorescence materials by an ether group strategy}, volume = {64}, year = {2025}, }
• (2025). All-N-heterocyclic-carbene protected superatomic ag8 cluster. ANGEW, 64(32), e202510845. (www)

  @article{ , abstract = {Atomically precise monolayer-protected coinage metal nanoclusters (CMNCs) have drawn increasing attention for their diverse structures and intriguing properties. Nevertheless, not all- N -heterocyclic-carbene (NHC)-protected atomically precise silver nanoclusters have been synthesized yet. Herein, we report the synthesis and crystal structure of the first all-NHC-protected superatomic silver cluster. This NHC-ligand-stabilized Ag 8 cluster, characterized as Ag 8 K 2 L 4 (CO 3 ) 2 (PF 6 ) 6 , was prepared by reacting Ag 2 O with bisimidazolium salt H 2 - L (PF 6 ) 2 under alkaline conditions in dimethylformamide via a one-pot reaction. The results of single-crystal X-ray diffraction analysis, multinuclear nuclear magnetic resonance (NMR) spectroscopy, and high-resolution electrospray-ionization (HR-ESI) mass spectrometry revealed a cluster centered with a stable Ag 8 ring. Energy decomposition analysis combined with the natural orbital for chemical valence method (EDA-NOCV) was employed to analyze the nature of the Ag–ligand bonding, and the results suggested that the stabilization energy originated from the strong electrostatic attraction of the Ag 8 ring to the NHC ligand. This work is expected to enable new applications of various NHC ligands in the formation of NHC-protected metal clusters with attractive properties.}, archive = {J_ANGEW}, author = {Li-Ying Sun and Fang Wang and Yuan Shui and Tao Yang and Ying-Feng Han}, doi = {10.1002/anie.202510845}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510845}, shortjournal = {Angew. Chem. Int. Edit.}, title = {All-N-heterocyclic-carbene protected superatomic ag8 cluster}, volume = {64}, year = {2025}, }
• (2025). Multi-ion coordinated water network in dilute acid electrolytes for ultralow-temperature (≤−80 °C) proton energy storage. ANGEW, 64(32), e202510830. (www)

  @article{ , abstract = {Proton batteries/capacitors, known for fast ion diffusion kinetics, are a promising alternative for low-temperature energy storage. However, ultralow-temperature (≤−60 °C) proton energy storage devices have been impeded by the strong corrosion of high-concentration acids and the high freezing point of low-concentration acids. Here, a strong-super-cooling electrolyte with a multi-ion coordinated water network (hybrid electrolyte of dilute acid and chaotropic zinc salt) is designed for fast proton transport at low temperatures. The chaotropic zinc salt not only reduces the number of free water but also minimizes the number of strong hydrogen bonds in the electrolyte, thus inhibiting the transition of the water molecules to an ordered arrangement at low temperatures. More importantly, the formation of stable Zn 2+ −H 2 O−ClO 4 − water molecule network, driven by strong interactions between ions, can effectively improve the proton transport to achieve the excellent rate performance of electrodes. This electrolyte also enables a long cycle life of the assembled CuHCF//α-MoO 3 for over 15 000 cycles below −60 °C, expediting the development of proton energy storage devices at ultralow temperatures.}, archive = {J_ANGEW}, author = {Tiezhu Xu and Zhaodi Cui and Tengyu Yao and Yuxuan Zhao and Laifa Shen}, doi = {10.1002/anie.202510830}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-ion coordinated water network in dilute acid electrolytes for ultralow-temperature (≤−80 °C) proton energy storage}, volume = {64}, year = {2025}, }
• (2025). Highly active pt-fe catalysts towards CO preferential oxidation with an ultra-wide temperature window. ANGEW, 64(32), e202510593. (www)

  @article{ , abstract = {Preferential oxidation of CO in H 2 (CO-PROX) is a promising solution to remove the residual CO in the feed stream to avoid Pt poisoning in proton-exchange-membrane fuel cells (PEMFCs), in which the development of high-efficiency catalysts with a wide temperature window remains a great challenge. Herein, we report a Fe(OH) x modified Pt clusters (∼1.6 nm) catalyst supported on MgAlO x (denoted as MA) derived from PtFeMgAl-layered double hydroxides (PtFeMgAl-LDHs) precursor, which is featured with abundant Pt δ + –(OH) x –Fe 3+ interfacial sites. Impressively, the optimal catalyst Pt-Fe(OH) x /MA exhibits exceptional catalytic performance towards CO-PROX, which can completely remove CO in a H 2 -rich stream with an ultra-wide full CO conversion window (25°C−225 °C) at a rather high space velocity (130 000 mL g cat −1 h −1 ). The mass-specific activity reaches to 9.09 mol CO g Pt −1 h −1 at 25 °C, which is preponderant to the state-of-the-art catalysts. In addition, a 240 h stream-on-line test over Pt-Fe(OH) x /MA shows a satisfactory stability. A comprehensive investigation based on in situ experimental studies and theoretical calculations reveals that the –OH group at the Pt δ + –(OH) x –Fe 3+ interfacial site is easily bound to the linearly-adsorbed CO at the adjacent Pt δ + site to form carboxylate intermediate, followed by its decomposition to CO 2 . Meanwhile, the generated coordination unsaturated Fe 2+ site facilitates the activation cracking of O 2 molecule without energy barrier. A structure design strategy of interfacial synergistic catalysis towards CO-PROX is proposed in this work, which shows fundamental significance and application prospects in hydrogen purification.}, archive = {J_ANGEW}, author = {Jun Yu and Boyu Song and Yusen Yang and Tianyong Liu and Zhe Li and Yang Han and Xusheng Liu and Hao Meng and Lei Wang and Lirong Zheng and Xin Zhang and Weili Dai and Min Wei}, doi = {10.1002/anie.202510593}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly active pt-fe catalysts towards CO preferential oxidation with an ultra-wide temperature window}, volume = {64}, year = {2025}, }
• (2025). Simultaneous boosting of second harmonic generation and circularly polarized luminescence in chiral hybrid metal halides through enhanced octahedral distortion. ANGEW, 64(32), e202510579. (www)

  @article{ , abstract = {Chiral hybrid metal halides (HMHs), characterized by their non-centrosymmetric crystal structures and exceptional photophysical properties, are promising for second-order nonlinear and linear optics, including second-harmonic generation (SHG) and circularly polarized luminescence (CPL). However, chiral HMHs with simultaneously strong SHG response and efficient CPL still present a challenge, due to the distinct structural and electronic requirements of these properties. Here, we report a halogen substitution strategy within inorganic octahedra to modulate the crystal structure and simultaneously enhance both SHG and CPL properties. Three pairs of chiral Sb-based HMHs are synthesized: ( R / S -MBA) 2 IASbBr 6 (MBA = α-methylbenzylammonium, IA = imidazole, abbreviated as R / S -SbBr 6 ), ( R / S -MBA) 2 IASbBr 2.8 Cl 3.2 ( R / S -SbBr 2.8 Cl 3.2 ), and ( R / S -MBA) 2 IASbCl 6 ( R / S -SbCl 6 ). The gradual halogen substitution from R / S -SbBr 6 to R / S -SbCl 6 significantly enhances the structural chirality of inorganic octahedra, resulting in a strong SHG response intensity of 1.4 × KDP and a high luminescence dissymmetry factor of 3.82 × 10 −2 . The combination of SHG and CPL performance outperforms that of previous chiral HMHs. Experimental results and theoretical calculations indicate that these enhancements originate from gradually increased octahedral distortions induced by halogen substitution. This work establishes a structural optimization strategy for advancing high-performance SHG and CPL in chiral HMHs, paving the way for their broader photonic applications.}, archive = {J_ANGEW}, author = {Yulian Liu and Xi Zhang and Xiaofan Xu and Junfeng Dai and Zewei Quan}, doi = {10.1002/anie.202510579}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous boosting of second harmonic generation and circularly polarized luminescence in chiral hybrid metal halides through enhanced octahedral distortion}, volume = {64}, year = {2025}, }
• (2025). Circumventing scaling relations via gradient orbital coupling promotes ammonia electrosynthesis on cobalt catalyst. ANGEW, 64(32), e202510478. (www)

  @article{ , abstract = {Highly efficient electrocatalytic nitrate reduction to ammonia (NH 3 ) relies on the balanced activation of various substrates including nitrate and water, but is currently hindered by the inherent scaling relations governing the adsorption of key reaction intermediates, such as *NO and *H. Herein, we develop a strategy to circumvent these limitations by introducing f–d–p gradient orbital coupling in cobalt oxide (Co 3 O 4 ) through Ce doping. Density functional theory calculations indicate that the lattice strain triggered by the dopant redistributes electron density at the Co and O sites, thereby modulating the adsorption strengths of *NO and *H, which favors the production of NH 3 while suppressing hydrogen evolution reaction. It exhibits a faradaic efficiency of 97.8% and a high yield rate of 3423.0 µg h −1 cm −2 under alkaline conditions. Furthermore, Ce/Co 3 O 4 catalyst shows robust performance over a wide range of nitrate concentrations (from 5 to 200 mM) and excellent cycling stability. Our findings also suggest that the gradient orbital coupling approach can be extended to other lanthanide dopants (e.g., Pr and Nd), offering a broadly applicable platform to break scaling relations and improve NO 3 − -to-NH 3 activity on cobalt catalysts.}, archive = {J_ANGEW}, author = {Hanle Liu and Shunhan Jia and Limin Wu and Ruhan Wang and Libing Zhang and Xinning Song and Xingxing Tan and Xiaodong Ma and Xiangyuan Jin and Hang Guo and Xiqing Sui and Qian Li and Rongjuan Feng and Lihong Jing and Qingli Qian and Jianling Zhang and Lei He and Xiaofu Sun and Buxing Han}, doi = {10.1002/anie.202510478}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510478}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Circumventing scaling relations via gradient orbital coupling promotes ammonia electrosynthesis on cobalt catalyst}, volume = {64}, year = {2025}, }
• (2025). The crucial role of oxygen evolution reaction in electrocatalytic oxidative C─C bond cleavage in lignin biomass valorization. ANGEW, 64(32), e202510437. (www)

  @article{ , abstract = {The electrocatalytic oxidative cleavage of the C─C bond is highly effective for converting lignin biomass into high-value-added aromatic chemicals. However, the oxygen evolution reaction (OER) at applied oxidative potential usually competes in the aqueous environment. In this study, we found that OER does not entirely hinder the cleavage process but rather acts as a synergistic catalytic step. By using defect-rich carbon nanotubes as the electrocatalyst and combining experimental and theoretical analysis, we found that the reactive oxygen species (O 2 − ) formed before *O 2 desorption serve as the key oxygen source. These species could interact with the enolate intermediate of lignin, which facilitates the in situ production of aromatic compounds. Under the optimal potential of 0.5 V versus Ag/AgCl, 98.8% of 2-phenoxyacetophenone is converted into phenol and benzoic acid via C α ─C β bond cleavage, with yields of 62.31% and 43.42%, respectively. Additionally, the depolymerization of quasi-natural poplar lignin achieves a total monomer yield of up to 12.41 wt%. This study provides new mechanistic insights into C α ─C β bond cleavage during electrocatalytic lignin depolymerization under alkaline conditions, contributing to efficient biomass valorization.}, archive = {J_ANGEW}, author = {Jingxuan Zhang and Wenjing Bai and Jianing Xu and Ao Zhou and Jialin Fan and Junlu Bi and Qingguo Zhou and Liyuan Gong and Yongzhuang Liu and Shuo Dou and Haipeng Yu and Shuangyin Wang}, doi = {10.1002/anie.202510437}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510437}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The crucial role of oxygen evolution reaction in electrocatalytic oxidative C─C bond cleavage in lignin biomass valorization}, volume = {64}, year = {2025}, }
• (2025). Inwardly directed linker propagation: Constructing 3D covalent organic frameworks for efficient H2O2 photosynthesis. ANGEW, 64(32), e202510293. (www)

  @article{ , abstract = {The limited design strategy of three-dimensional covalent organic frameworks (3D COFs) greatly restricts their structural diversification and potential applications. Herein, we propose an inwardly directed linker propagation strategy for the targeted assembly of 3D COFs (COF-IN-1 and COF-IN-2) and compare them with outwardly directed expanded COFs (COF-OUT-1 and COF-OUT-2). COF-OUTs exhibit planar heteroporous 2D frameworks with cpt topology, while COF-INs engineer controlled triple entanglements into networks, forming 3D frameworks with acs topology. Moreover, the COFs assembled via inwardly directed linker propagation effectively enhanced the production of H 2 O 2 photosynthesis. To demonstrate the application potential, a biphasic fluid system was constructed for continuous H 2 O 2 photosynthesis and extraction. This work not only expands the design strategy for achieving 3D COFs but also demonstrates that the dimensional regulation of frameworks and tuning of applications can arise from different expanding directions of the linkers.}, archive = {J_ANGEW}, author = {Ruo-Meng Zhu and Yong Liu and Wang-Kang Han and Jing-Dong Feng and Yu-Ou He and Huan Pang and Jiangwei Zhang and Zhi-Guo Gu}, doi = {10.1002/anie.202510293}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510293}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inwardly directed linker propagation: Constructing 3D covalent organic frameworks for efficient H2O2 photosynthesis}, volume = {64}, year = {2025}, }
• (2025). Thio-tetracosulene: A highly twisted molecular plectoneme. ANGEW, 64(32), e202510210. (www)

  @article{ , abstract = {We report the synthesis and characterization of thio-tetracosulene 3 , a highly twisted chiral macrocycle constructed via sulfur fluorine annulative substitution from a cyclometaphenylene derivative. It is the first macrocyclic aromatic compound with a plectonemic configuration, and the structure is unambiguously confirmed by single crystal X-ray diffraction study. The two enantiomers of 3 can be resolved to investigate their chiroptical properties. In contrast to the known topological knot-, or Möbius-type macrocycles which induce chirality by specific connection patterns, the asymmetric structure of 3 is formed and maintained by the tendency of a ring in distress to reduce unfavorable strains.}, archive = {J_ANGEW}, author = {Yiqiang Ou and Chaoqun Zhao and Long Jiang and Yanpeng Zhu and Kelong Zhu and Jiaobing Wang}, doi = {10.1002/anie.202510210}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202510210}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thio-tetracosulene: A highly twisted molecular plectoneme}, volume = {64}, year = {2025}, }
• (2025). Markus d. kärkäs. ANGEW, 64(32), e202509977. (www)

  @article{ , archive = {J_ANGEW}, author = {Markus D. Kärkäs}, doi = {10.1002/anie.202509977}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509977}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Markus d. kärkäs}, volume = {64}, year = {2025}, }
• (2025). Zhishuai geng. ANGEW, 64(32), e202509857. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhishuai Geng}, doi = {10.1002/anie.202509857}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509857}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zhishuai geng}, volume = {64}, year = {2025}, }
• (2025). Fast removing ligands from platinum-based nanocatalysts by a square-wave potential strategy. ANGEW, 64(32), e202509746. (www)

  @article{ , abstract = {Developing effective methods to remove ligands from the surface of nanoparticles (NPs) is crucial for obtaining surface-cleaned nanocatalysts. In this manuscript, we develop a square-wave potential (SWP) strategy that efficiently removes ligands from the surface of platinum (Pt)-based nanocatalysts within 1 min (40 s), achieving a removal efficiency 30 times higher than that of traditional cyclic voltammetry cycling. Comprehensive analyses of physical characterization and catalytic performance confirm the effectiveness of the SWP strategy. In situ electrochemical infrared and Raman spectroscopy show that the oxidation potential (1.24 V) can replace the Pt-N coordination bond with a Pt─O covalent bond to form the intermediate state of Pt-O-NH 2 R during ligand removal, while the reduction potential (0.20 V) can detach the ligand from the surface of Pt. Moreover, the SWP strategy is versatile, extending the efficient removal of various ligands from the surface of Pt and the oleylamine ligand from Pt-based alloy nanocatalysts. The efficient removal of ligands from nanocatalysts is critical for ensuring the reproducibility of electrocatalytic results and for obtaining clean catalysts to reveal intrinsic effects in nanocatalysis.}, archive = {J_ANGEW}, author = {Rui Xu and Lingshan Liao and Wenya Liang and Huaiyi Wang and Qiusheng Zhou and Wenke Liu and Mengting Chen and Baizeng Fang and Di Wu and Haiyan Jin and Yunxia Li and Shihui Zou and Linfang Lu}, doi = {10.1002/anie.202509746}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fast removing ligands from platinum-based nanocatalysts by a square-wave potential strategy}, volume = {64}, year = {2025}, }
• (2025). Modulating diffusion kinetics and interfacial stability via in-situ constructed self-healing interfaces for highly reversible zinc metal anodes. ANGEW, 64(32), e202509622. (www)

  @article{ , abstract = {Commercial Zn anodes contain inherent manufacturing defects, such as scratches, rough surfaces, fold lines, and microcracks. These surface defects damage the uniformity of the interfacial electric field, exacerbate hydrogen evolution problem and dendrite growth. Herein, a self-healing polymer interface is constructed by unsaturated N -(hydroxymethyl)acrylamide molecules (NHMA) self-polymerization. The layer effectively suppresses the detrimental tip effect and enhances the interface stability. Meanwhile, it synergistically facilitates the diffusion kinetics of Zn ions and regulates orientated deposition, thereby enabling an efficient repair of scratches on the Zn surface. Furthermore, the NHMA with acylamino and hydroxyl groups is capable of modulating the hydrogen bond network and solvation structure of the electrolyte, further improving the stability of the electrode–electrolyte interface. Benefiting from the enhanced diffusion kinetics and stable NHMA-derived interfaces, the fabricated symmetrical battery demonstrates a 50-fold improvement in cycle life under various testing conditions. Moreover, the full battery can maintain a capacity of 101.8 mAh g −1 after 3000 cycles at 5 A g −1 (1.5 times higher than bare Zn//NH 4 V 4 O 10 ). This work establishes a novel framework for rational electrolyte engineering and interfacial modulation in aqueous Zn metal batteries, offering fresh perspectives for future research toward practical energy storage applications.}, archive = {J_ANGEW}, author = {Han Tang and Hongyu Luo and Gongtao Yu and Jiale Wan and Lu Wu and Feiyang Chao and Wenwei Zhang and Lianmeng Cui and Yu Liu and Ping Luo and Qinyou An}, doi = {10.1002/anie.202509622}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509622}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating diffusion kinetics and interfacial stability via in-situ constructed self-healing interfaces for highly reversible zinc metal anodes}, volume = {64}, year = {2025}, }
• (2025). NPA6: A molecule for non-covalently linked radical-enhanced ISC and high-performance photopolymerization with afterglow. ANGEW, 64(32), e202509520. (www)

  @article{ , abstract = {To harness electron spin exchange for radical-enhanced intersystem crossing (ISC), a typical strategy involves covalently attaching stable radicals to chromophores. Here, we introduce NPA6, synthesized by attaching heptanamide to N , N -diphenylnaphthalen-1-amine (NPA). NPA6 maintains the phosphorescent properties of NPA and exhibits unique photo-generated radical behavior that is absent in NPA. These radicals can further adsorb neutral molecules to form supramolecular assemblies. Compared to pristine NPA6, these assemblies exhibit nearly complete NMR proton signal suppression in the aromatic region, enhanced absorption near 400 nm, and reduced fluorescence intensity. Phosphorescence measurements at 77 K reveal stronger phosphorescence in the assemblies, with delayed excitation spectra confirming phosphorescence originating exclusively from neutral molecules, indicating successful noncovalent radical-enhanced ISC. As a photosensitizer in N , N -dimethylacrylamide polymerization, NPA6 achieves nearly 100% conversion at 100 ppm under 410 nm light and ambient conditions, exhibiting superior polymerization performance. Additionally, its afterglow makes it suitable as an in situ quality indicator for transparent coatings, suggesting its potential applications in photolithography.}, archive = {J_ANGEW}, author = {Kexin Wang and Chuanhao Liu and Yuling He and Guiyin Luo and Tao Zhang and Jiaqi Su and Binghao Li and Wenxiao Deng and Yanju Luo and Zhiyun Lu and Yan Huang}, doi = {10.1002/anie.202509520}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509520}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NPA6: A molecule for non-covalently linked radical-enhanced ISC and high-performance photopolymerization with afterglow}, volume = {64}, year = {2025}, }
• (2025). Janus superiority of membranes in chemical engineering and beyond. ANGEW, 64(32), e202509503. (www)

  @article{ , abstract = {Janus configurations, characterized by their inherent asymmetry, enable directional mass transfer in membrane materials that drive novel and energy-efficient chemical processes. This Janus superiority spans applications from nanoscale molecular and ionic transport to macro-scale separation systems with asymmetric spatial architectures. This review provides an analysis of the material foundations including design principles, structure regulation, and scalability challenges underlying Janus membranes. We explore the physics that governs their unique behavior and examine their diverse applications across chemical engineering, including phase transfer, and molecular or ionic transport. Through a multiscale perspective, we provide a comprehensive understanding of the impact of Janus superiority in advancing chemical engineering technologies. Finally, we discuss the hurdles in translating theoretical advances into practical applications and propose promising avenues for future research to harness the full potential of Janus membranes and systems in addressing global challenges related to energy, sustainability, and beyond.}, archive = {J_ANGEW}, author = {Hao-Cheng Yang and Yi-Zhou Chen and Kai Li and Xin-Yu Guo and Qi-Rui Jiang and Seth B. Darling and Zhi-Kang Xu}, doi = {10.1002/anie.202509503}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509503}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Janus superiority of membranes in chemical engineering and beyond}, volume = {64}, year = {2025}, }
• (2025). Molecule-cooperative strategy for dopant-free hole transporting layer toward fully printed high-performance perovskite solar cell modules. ANGEW, 64(32), e202509459. (www)

  @article{ , abstract = {Enabling large-area deposition of dopant-free organic hole transport layers (HTLs) with high reproducibility and uniformity is crucial for fully printed n-i-p perovskite solar cell (pero-SC) modules. However, typical polymer hole transport materials (HTMs), with non-Newtonian fluid characteristics, show shear rate-dependent viscosity during the printing process, whereas blade-coated small-molecule HTLs often exhibit unfavorable assembly behavior and solute random distribution caused by molecular aggregation and low viscosity; these factors impose challenges on blade-coating of high-quality large-area HTL films. Here, we designed a dopant-free small molecule BDT-MB with high mobility and further proposed a molecular cooperative (MC) strategy by combining with polymer D18. The mechanism was clearly clarified that the pre-aggregated polymer D18 acted as a “seed crystal” to induce preferential face-on orientation of small molecule BDT-MB through intermolecular C─H···π interaction. This strategy not only suppresses the unfavorable assembly behavior of small molecular HTMs but also overcomes the solute random distribution by tuning the solution with high and constant viscosity. It facilitates printing large-area dopant-free HTLs with high uniformity and ordered fiber-like morphology. The resultant small-area pero-SCs (0.062 cm 2 ) and large-area fully printed modules (15.64 cm 2 ) both achieved record power conversion efficiencies (PCEs) of 24.46% (certified at 24.30%) and 21.04%.}, archive = {J_ANGEW}, author = {Qinrong Cheng and Hongxiang Li and Weijie Chen and Yixin Cao and Junyuan Ding and Yue Yin and Jiacheng Xu and Haiyang Chen and Jianlei Cao and Yaowen Li}, doi = {10.1002/anie.202509459}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecule-cooperative strategy for dopant-free hole transporting layer toward fully printed high-performance perovskite solar cell modules}, volume = {64}, year = {2025}, }
• (2025). AIE-driven chiral covalent organic frameworks for solid-state circularly polarized luminescence, hydrochromism, and water-induced chiroptical enhancement. ANGEW, 64(32), e202509454. (www)

  @article{ , abstract = {Chiral covalent organic frameworks (CCOFs) are promising candidates for chiral optoelectronics and sensing, but their weak solid-state fluorescence and chiroptical responses often limit practical utility. Here, we introduce a novel CCOF synthesized from achiral monomers, 2-hydroxy-1,3,5-benzenetricarbaldehyde and hydrazine, via imine condensation with a chiral induction strategy, yielding salicylaldehyde azine units with aggregation-induced emission. Optimized catalyst and chiral inducer stoichiometry endow the framework with exceptional chiroptical properties (|g abs | = 2.2 × 10 −2 , ellipticity ≈ 1000 mdeg). In the solid state, the CCOF exhibits intense red fluorescence (λ em ≈ 645 nm) with a large stoke shift and favorable circularly polarized luminescence (CPL, |g lum | = 5.2 × 10 −2 ), marking the first CCOF derived solely from achiral building blocks with robust solid-state CPL. When integrated into polydimethylsiloxane, it forms flexible and semitransparent composite films suitable for CPL-based applications. The CCOF also functions as a highly enantioselective fluorescent sensor for chiral analytes, including 2-aminocyclohenanol and dimethyl-1,2-cyclohexanediamine. Furthermore, it demonstrates reversible hydrochromism, transitioning from yellow to orange (ΔE ≈ 42.7), and water-induced chiroptical enhancement (ellipticity up to 2100 medg, |g abs | = 5.5 × 10 −2 ), achieving the highest ground-state chirality reported for CCOFs through enol-to-keto tautomerism upon water adsorption. This stimuli-responsive CCOF overcomes persistent limitations in solid-state CPL and paves the way for chiral sensing, optical displays, and responsive materials.}, archive = {J_ANGEW}, author = {Mengjuan Zuo and Xinlin Zha and Zhenzhen Jiang and Mengying Luo and Zhong Yan and Haining You and Xing Qing and Yi Xiong and Ying Liu and Liu Liu and Yingying Li and Wen Wang and Mufang Li and Dong Wang}, doi = {10.1002/anie.202509454}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509454}, shortjournal = {Angew. Chem. Int. Edit.}, title = {AIE-driven chiral covalent organic frameworks for solid-state circularly polarized luminescence, hydrochromism, and water-induced chiroptical enhancement}, volume = {64}, year = {2025}, }
• (2025). Operando spectroscopic insights into CO2 reduction at Electrode/Polyelectrolyte interfaces. ANGEW, 64(32), e202509423. (www)

  @article{ , abstract = {The electrode/polyelectrolyte interface is a notable feature in modern electrochemical technologies that utilize membrane electrode assembly (MEA) configurations. However, its interfacial structure and catalytic behavior remain poorly understood. Here, we developed an integrated operando Raman spectroscopy and mass spectrometry (MS) method, to directly investigate the CO 2 reduction mechanism at the electrode/polyelectrolyte interface within a practical MEA electrolyzer operating at high current densities. Combined with isotope labeling experiments and ab initio molecular dynamics (AIMD) simulations, we provide, for the first time, the direct spectroscopic evidence of *CCO, a crucial intermediate for C 2 product formation, which has been frequently hypothesized but rarely detected in previous studies. By contrast, the linearly adsorbed *CO L intermediate, typically observed in conventional liquid electrolytes, was absent. These distinct behaviors arise from the unique structure of the electrode/polyelectrolyte interface, which shifts the rate-determining step from the usual C–C coupling to the *CCO hydrogenation in the conversion of CO 2 to C 2 products. This study not only deepens our understanding of electrode/polyelectrolyte interfacial characteristics but also offers valuable insights for advancing the performance of CO 2 MEA electrolyzers.}, archive = {J_ANGEW}, author = {Jieyu Wang and Bing Huang and Li Xiao and Gongwei Wang and Lin Zhuang}, doi = {10.1002/anie.202509423}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509423}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Operando spectroscopic insights into CO2 reduction at Electrode/Polyelectrolyte interfaces}, volume = {64}, year = {2025}, }
• (2025). Tailoring coordination microenvironment of nickel molecular complexes for electrooxidation of organic nucleophiles. ANGEW, 64(32), e202509377. (www)

  @article{ , abstract = {Electrochemical oxidation of organic nucleophiles to value-added chemicals using nickel-based catalysts is promising yet hindered by the dynamic evolution of nickel coordination structures during catalysis. Herein, we engineered atomically exposed nickel molecular catalysts anchored on functional carbon black through tailored aromatic ligands coordination. This unique spatial coordination structure efficiently promotes the reconstruction of high-valence Ni III -OOH sites, which boost electrooxidation of 18 organic substrates with peak current density exceeding 800 mA cm −2 . Especially, the optimal electrocatalyst achieves record mass activities of 4.38 and 4.26 A mg Ni −1 for methanol and ethylene glycol oxidation, respectively. In situ characterization and theoretical analyses elucidate that the atomically exposed Ni III -OOH centers would directly adsorb organic substrates, thereby enhancing C─C/C─H bonds cleavage efficiency. Meanwhile, the proton abstraction from C─H bond would enable reversible redox cycling between Ni II -OH and Ni III -OOH, sustaining catalytic activity. This study advances the understanding of organic oxidation mechanisms and showcases the great potential of molecular complexes in electrocatalysis.}, archive = {J_ANGEW}, author = {Chengdong Yang and Yun Gao and Yueqing Wang and Wenwen Cai and Jizhen Ma and Jintao Zhang}, doi = {10.1002/anie.202509377}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509377}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring coordination microenvironment of nickel molecular complexes for electrooxidation of organic nucleophiles}, volume = {64}, year = {2025}, }
• (2025). Achieving highly efficient luminescence and multiphoton absorption character in thermally activated delayed fluorescence emitters based on a Tetrabenzo[a,c]Phenazine core. ANGEW, 64(32), e202509348. (www)

  @article{ , abstract = {The integration of multiphoton absorption phenomenon (MPA) with thermally activated delayed fluorescence (TADF) materials opens new avenues for bio-optoelectronic applications. However, the development of TADF emitters that simultaneously exhibit triplet harvesting and MPA is hindered by the challenge of balancing molecular planarity, reduced orbital overlap, and large oscillator strength. In this study, we demonstrate a quadrupolar molecular design based on the tetrabenzo[ a , c ]phenazine (TBPZ) to accomplish efficient MPA and TADF performance. Two new TADF emitters, TBPZ2TPA and TBPZ2NP , were synthesized, featuring an electron-accepting TBPZ core and electron-donating triarylamine (TAA) units to achieve an optimal balance between TADF and MPA characteristics. Particularly, TBPZ2TPA blended film exhibits orange-red emission with a maximum at 589 nm, a high photoluminescence quantum yield ( Ф PL ) of 71%, a sufficiently small singlet-triplet energy gap (Δ E ST ) of 0.16 eV and reversed intersystem crossing rate ( k RISC ) of 1.3 × 10 4 s −1 . Furthermore, it demonstrated a remarkable two-photon absorption (2PA) cross-section ( σ 2 ) of 892 GM at 780 nm and an excellent 2PA brightness of 785 GM, along with evident three-photon absorption (3PA) at 1200 nm. These results provide a compelling strategy for developing high-performance TADF emitters with exceptional MPA properties, enabling dual functionality for both OLEDs and high-resolution bioimaging.}, archive = {J_ANGEW}, author = {Gomathi Vinayakam Mageswari and Youhei Chitose and Yu-Ming Li and Zhe-Wei Fan and Yun-Yi Kao and Umamahesh Balijapalli and Ja-Hon Lin and Tzu-Chau Lin and Chihaya Adachi}, doi = {10.1002/anie.202509348}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving highly efficient luminescence and multiphoton absorption character in thermally activated delayed fluorescence emitters based on a Tetrabenzo[a,c]Phenazine core}, volume = {64}, year = {2025}, }
• (2025). Continuous intermediates spillover boosts electrochemical nitrate conversion to ammonia over dual single-atom alloy. ANGEW, 64(32), e202509303. (www)

  @article{ , abstract = {Electrochemical nitrate conversion to ammonia driven by sustainable green electricity is regarded as a promising supplement to the traditional Haber–Bosch process. However, it is still restricted by the low NH 3 yield rate and Faradaic efficiency. Here, we propose a continuous intermediates spillover strategy by constructing dual single-atom alloy to boost ammonia yield rate and Faradaic efficiency. The intermediates continuously spill over back and forth on the atomically dispersed Mo and Fe sites in Pd lattice, which adaptively experiences low energy barrier for each elementary step in nitrate conversion. As a result, the synthesized dual single-atom alloy metallene delivered an NH 3 yield rate of 13.4 mol g cat. −1 h −1 , and Faradaic efficiency of 94.6%, as well as remarkable cycling stability of 300 h. Furthermore, the dual single-atom alloy metallene was assembled into a zinc-nitrate battery as the cathode, which delivered an output voltage of 1.477 V, and the maximum output power density of 13.4 mW cm −2 .}, archive = {J_ANGEW}, author = {Wei Ye and Yuanhui Yao and Xiaofei Wei and Mengqiu Xu and Shuang Zhao and Wei Wang and Gan Jia and Fangna Dai and Peng Gao and Xiaoqing Lu and Xiaogang Li and Baojuan Xi and Nana Wang and Shenglin Xiong}, doi = {10.1002/anie.202509303}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509303}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Continuous intermediates spillover boosts electrochemical nitrate conversion to ammonia over dual single-atom alloy}, volume = {64}, year = {2025}, }
• (2025). NbGa2S4(S2): A rare linear [S2]2− coordination to niobium resulting in simultaneously large SHG effect and giant birefringence. ANGEW, 64(32), e202509238. (www)

  @article{ , abstract = {We report a novel niobium thiogallate, NbGa 2 S 4 (S 2 ), featuring a rare linear [S 2 ] 2− coordination to niobium, which simultaneously exhibits a strong second harmonic generation effect [1.5 × benchmark AgGaS 2 (AGS)], a high laser-induced damage threshold (5.7 × AGS), and a giant birefringence (0.29 at 2 µm, the largest among all reported 3D chalcogenides). Theoretical studies reveal that the polarizability anisotropy and hyperpolarizability are significantly enhanced due to the unique alignment of [S 2 ] 2− dimer within the crystal lattice. Additionally, the compound demonstrates exceptional chemical bond flexibility, which leads to significantly reduced thermal anisotropic expansion, one order of magnitude smaller than that of the benchmark AGS. These findings provide valuable insights for the design of next-generation functional materials with tailored optical and thermal characteristics.}, archive = {J_ANGEW}, author = {Wen-Li Zhao and Rui-Xi Wang and Shuang Zhao and Li-Ming Wu and Ling Chen}, doi = {10.1002/anie.202509238}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509238}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NbGa2S4(S2): A rare linear [S2]2− coordination to niobium resulting in simultaneously large SHG effect and giant birefringence}, volume = {64}, year = {2025}, }
• (2025). Single-specie selectivity via subnanometer hierarchical porous channel metal-organic gels toward ultra-stable anodes for zn metal batteries. ANGEW, 64(32), e202509236. (www)

  @article{ , abstract = {Gel polymer electrolytes demonstrate substantial potential for aqueous zinc-ion batteries, yet obtaining exquisite balance between molecular/ion sieving precision enhancement and ion conduction pathway optimization remains a persistent scientific challenge. Here, to assure long-term stabilized zinc electrodeposition, a polyacrylonitrile (PAN)-Zn(ClO 4 ) 2 -DMF metal-organic gel (MOG) embedded with hierarchical sub-nanochannels was strategically designed to facilitate single-specie selectivity toward Zn 2+ . In accordance with the ion-sieving transition state theory, the MOG accomplished directional discrimination of DMF solvent and ClO 4 − species via synergistic size exclusion effect and interaction force (dipole–dipole interaction, electrostatic interaction and vdW force), which specifically reduces the sieving activation energy of Zn 2+ . Furthermore, ClO 4 − anions with optimized microstructural dimensions and strong coordination ability have stronger interactions with PAN chain segments and promote the dissociation of Zn 2+ from PAN chain segments, which facilitates a smooth Zn 2+ flux through distinctive ion transport pathways. Besides, the PAN@ClO 4 − complex demonstrates sustainable epitaxial stacking characteristics of crystallographically oriented Zn (002) planes, which promote flat and compact Zn deposition. Consequently, the zinc symmetric battery demonstrates an exceptional cycle life exceeding 7000 h at 0.2 mA cm −2 , with extremely lower overpotential (20 mV). Furthermore, the Zn||I 2 cell maintains a capacity retention rate of 81.7% after 10 000 cycles at 0.5 A g −1 .}, archive = {J_ANGEW}, author = {Xiaolong Jiang and Haoxin Liu and Zixin Han and Zuyang Hu and Kai Bai and Yufei Zhang and Wencheng Du and Minghui Ye and Yongchao Tang and Xiaoqing Liu and Zhipeng Wen and Cheng Chao Li}, doi = {10.1002/anie.202509236}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509236}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-specie selectivity via subnanometer hierarchical porous channel metal-organic gels toward ultra-stable anodes for zn metal batteries}, volume = {64}, year = {2025}, }
• (2025). Light-driven ligand exchange for palladium-catalyzed regiodivergent transfer hydrothiocarbonylation. ANGEW, 64(32), e202509228. (www)

  @article{ , abstract = {Transfer hydrocarbonylation of alkenes could streamline the synthesis of value-added carbonylated molecules by avoiding the use of pressurized toxic CO. Existing methods, however, are limited to the use of alcohol-derived formates or anhydrides as CO and nucleophile-surrogates, because the parallel mechanism does not work for other transfer carbonylation reagents comprising nucleophilic fragments with higher coordination affinities to transition metals. Herein, we present a novel visible-light-driven strategy to address this challenge by promoting the ligand exchange via facilitating the dissociation of CO instead of nucleophiles, upon which was also an efficient transfer hydrothiocarbonylation of olefins with thioformates successfully established. The protocol features mild reaction conditions, excellent regioselectivities, broad functional group compatibilities, and vital synthetic efficacy. The kinetic analysis unveiled a striking linear correlation between the product concentration and the time-squared. Furthermore, the kinetic behaviors observed for the substrates were all consistent with the rate law derived from the proposed mechanism. These results demonstrated the pivotal importance of rapid CO dissociation via light excitation to suppress the side reaction of premature reductive elimination.}, archive = {J_ANGEW}, author = {Bao Gao and Ruiting Yang and Zeyu Zhao and Tianze Zhang and Hongchi Liu and Hanmin Huang}, doi = {10.1002/anie.202509228}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509228}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-driven ligand exchange for palladium-catalyzed regiodivergent transfer hydrothiocarbonylation}, volume = {64}, year = {2025}, }
• (2025). Solvent-induced chirality inversion in propeller-shaped PDI oligomers with bright circularly polarized luminescence. ANGEW, 64(32), e202509190. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) has the potential for next-generation optoelectronic applications. One of the major challenges in this field is the development of CPL emitters, whose emission properties can be modulated by external stimuli, such as solvents. However, CPL-active materials are often synthetically demanding and typically require chiral separation. To address these limitations, we have synthesized a propeller-shaped molecule, ( R / S )-Bz-6PDI 1 , via a one-pot nucleophilic aromatic substitution reaction, using a chiral pyrrole-fused perylene diimide (PDI) 4 as the blade. The introduction of a chiral auxiliary into the blade enabled the induction of propeller chirality without the need for chiral chromatographic separation. ( R )-Bz-6PDI 1 exhibited high CPL brightness in solution ( B CPL = 103–369 M −1 cm −1 ). Furthermore, the propeller chirality proved highly sensitive to the solvent environment, leading to significant modulation of both the sign and intensity of the CD and CPL signals, including complete signal inversion in CH 2 Cl 2 and CHCl 3 . CD spectral analysis combined with DFT calculations revealed that the propeller chirality is governed by the orientation of the hydrogen atom in the chiral auxiliary.}, archive = {J_ANGEW}, author = {Yuma Tanioka and Masayoshi Takase and Mashiro Hamasu and Shogo Hata and Kohei Hashimoto and Shigeki Mori and Yukihide Ishibashi and Yuki Nukumi and Masahiro Higashi and Hirofumi Sato and Tetsuo Okujima and Hidemitsu Uno}, doi = {10.1002/anie.202509190}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-induced chirality inversion in propeller-shaped PDI oligomers with bright circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Quaternized-PAF architecture mediated proton channels to enhance ultra-robust operation for 200 °C proton exchange membrane fuel cells. ANGEW, 64(32), e202509085. (www)

  @article{ , abstract = {In optimizing the trade-off between power density and phosphoric acid (PA) retention in PA-doped polybenzimidazole (PA-PBI) membrane for improving performance of high-temperature proton exchange membrane fuel cells (HT-PEMFCs), the self-reinforcing network of interfacial interactions of the HT-PEMs has to be deeply investigated. In this paper, a breakthrough strategy employing a quaternary ammonium (QA)-functionalized porous aromatic framework (QPAF-225) to synergistically integrate with sulfonated poly[2,2′-(p-oxydiphenylene)-5,5′-bibenzimidazole] (SOPBI) to form the robust HT-PEM is successfully developed. The ionic interactions between the cationic QA moieties and anionic sulfonic acid groups can establish a self-reinforcing proton-conductive network, while the high-density basic sites in QPAF-225 act as the PA reservoirs and can mitigate the leakage. When benchmarked against QA-deficient PAF-225–10 (10% PAF-225 in composite membrane) composite HT-PEMs and pristine SOPBI, the QPAF-225–10 composite delivers a high proton conductivity of 174 mS cm −1 at 200 °C and extremely high peak power density of 847 mW cm −2 of the HT-PEMFC under ultralow Pt/C loading (0.3 mg cm −2 ) at 200 °C operation, which surpasses most of PA-PBI systems reported in literatures. Critically, such a membrane exhibits ultralow voltage decay rate (0.04 mV h −1 over 904 h at 200 °C) and high PA retention ability, coupled with mechanical robustness exceeding industrial durability thresholds. This work transcends conventional additives by exploiting porous aromatic framework-mediated proton channels and PA-philic motifs, establishing a material paradigm for next-generation HT-PEMs that reconciles high-power operation with long-term stability in harsh electrochemical environments.}, archive = {J_ANGEW}, author = {Xinyi Zong and Haina Mi and Fei Chen and Xianfeng Guan and Yuhan Liu and Wei Hu and Nanwen Li and Chunzhu Jiang and Yunfeng Lu and Guangshan Zhu and Wei Yan and Jiujun Zhang}, doi = {10.1002/anie.202509085}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quaternized-PAF architecture mediated proton channels to enhance ultra-robust operation for 200 °C proton exchange membrane fuel cells}, volume = {64}, year = {2025}, }
• (2025). Scalable H2O2 production via o2 reduction using immobilized vanadyl phthalocyanine. ANGEW, 64(32), e202509079. (www)

  @article{ , abstract = {The production of hydrogen peroxide (H 2 O 2 ) via the two-electron oxygen reduction reaction (ORR) has emerged as a promising alternative to the conventional anthraquinone process. However, achieving selective H 2 O 2 production at practically relevant current densities (i.e., ampere-level) remains challenging due to significant selectivity deterioration at high rates. In this study, we develop a composite catalyst by immobilizing vanadyl phthalocyanine (VOPc) on carbon nanotube (CNT) substrates and evaluate its performance under conditions relevant to practical ORR electrolysis. Encouragingly, the VOPc/CNT catalyst composite achieves a high ORR current density of up to 3.5 A cm −2 with over 90% selectivity toward H 2 O 2 in acidic media. Through various in situ characterizations and theoretical calculations, we reveal that the structural integrity of the vanadium catalytic center in VOPc plays a pivotal role in stabilizing *OOH adsorption and impeding O─O cleavage under high cathodic potentials, which is critical for achieving high H₂O₂ selectivity at elevated current densities.}, archive = {J_ANGEW}, author = {Haozhou Yang and Na Guo and Shibo Xi and Jiaxi Yin and Tao Song and Yukun Xiao and Lele Duan and Chun Zhang and Lei Wang}, doi = {10.1002/anie.202509079}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509079}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable H2O2 production via o2 reduction using immobilized vanadyl phthalocyanine}, volume = {64}, year = {2025}, }
• (2025). Self-assembly of a customizable library of nickel trifluoromethylation catalysts via selective C─F and C─O bond cleavage. ANGEW, 64(32), e202509042. (www)

  @article{ , abstract = {Using a combination of metal-promoted reactivity, in situ covalent bond modification, and hydrogen bonding-promoted fluorine labilization, a unified approach was developed to self-assemble a library of customizable ligand architectures directly at the nickel center via selective cleavage of C─F or C─O bonds and the formation of C─C or C─N bonds. As a result, a structurally diverse set of nickelacarbatrane and pincer complexes was obtained, including unsymmetrical and mixed-heterocyclic atranes and trifluoromethylated pincers that cannot be accessed by conventional organic synthetic methods or require multiple steps and a tedious and low-yielding separation. This suggests a possibility of a spontaneous generation of high-complexity structures from a commonly used metal precursor and simple N-heterocycle building blocks, despite commonly believed innocence of the C─F bonds, which may also generate catalytically active species.}, archive = {J_ANGEW}, author = {Aleksandr Sorvanov and Shubham Deolka and Eugene Khaskin and Robert R. Fayzullin and Serhii Vasylevskyi and Julia R. Khusnutdinova}, doi = {10.1002/anie.202509042}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202509042}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembly of a customizable library of nickel trifluoromethylation catalysts via selective C─F and C─O bond cleavage}, volume = {64}, year = {2025}, }
• (2025). Giant birefringence and solar-blind ultraviolet transmission by coordination-induced assembly of π-conjugated Pyridine–Carboxylate. ANGEW, 64(32), e202508997. (www)

  @article{ , abstract = {Giant birefringent crystal with large bandgap is of paramount importance for modern optical devices but simultaneous achievement of giant birefringence and large bandgap is a great challenge stemming from their inherent contradictory relationship according to Kramers‒Kronig equation. Herein, an organic–inorganic hybrid uniformly-stacked 2D crystal [Be 2 (μ-OH) 2 (C 7 H 3 NO 4 )(H 2 O)]·H 2 O ( I ) was successfully synthesized by a molecular crystal engineering involving hydrogen bond synthons. Layered I features new [Be 2 O 2 N(μ-OH) 2 (H 2 O)] ∞ helical chain composed of Be II tetrahedral coordination, and the strong covalent Be II cations coordinate with the O and N atoms on birefringence-active π-conjugated (C 7 H 3 NO 4 ) 2− organic groups with optimal spatial arrangement. As a result, I demonstrates the largest birefringence of 0.6 in the solar-blind UV spectral region, with large bandgap of 4.75 eV and short UV absorption edge of 261 nm. First-principles calculations and structural analyses uncover that the superior optical properties mainly originate from collective effects of highly-active (C 7 H 3 NO 4 ) 2− groups, distorted Be-tetrahedral units, and their uniform stacking. This work not only provides a potential solar-blind UV birefringent crystal for rapidly increasing number of optical applications but also a new chance for the rational design of wide UV giant birefringent crystals.}, archive = {J_ANGEW}, author = {Peng-Hui Guo and Xia Zhang and Yao Guo and Nan Zhang and Yi-Gang Chen and Xingxing Jiang and Zheshuai Lin and Xian-Ming Zhang}, doi = {10.1002/anie.202508997}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508997}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Giant birefringence and solar-blind ultraviolet transmission by coordination-induced assembly of π-conjugated Pyridine–Carboxylate}, volume = {64}, year = {2025}, }
• (2025). Solution-mediated photoreversible switch between 2D and 3D hydrogen-bonded organic frameworks. ANGEW, 64(32), e202508976. (www)

  @article{ , abstract = {In photoresponsive crystalline porous materials, the light-driven reversible topological transformation is of particular interest, as it can cause an overall change in structure and lead to more drastic switch in material properties, but remains a formidable challenge. Herein, we report a three-dimensional (3D) hydrogen-bonded organic framework ( HOF-OF ) self-assembled by photochromic diarylethene (DAE) and tetrakis(4-amidiniumphenyl)methane (TAM) via charge-assisted hydrogen bonds. Light irradiation drives isomerization of DAE, and the internal strain generated during photoisomerization is released through dissolution and recrystallization, which are accompanied by the breaking and reestablishment of hydrogen bonds. Benefit from the weak and reversible nature of hydrogen bonds as well as the good solution processability of HOFs, solution-mediated reversible switch between 3D and two-dimensional (2D) HOF is achieved by ring-open/ring-close photoisomerization of the DAE moiety controlled by remotely alternating UV and visible light irradiation. Loading lanthanide complex into HOF enables DAE photoisomerization-controlled photochromic fluorescence resonance energy transfer process between the lanthanide and DAE moiety, resulting in reversible luminescence on/off switch in the host-guest, capable of intelligent anti-counterfeiting in a noninvasive manner.}, archive = {J_ANGEW}, author = {Xiao Liu and Yingxiang Ye and Xu He and Qingyu Niu and Zhiqiang Li}, doi = {10.1002/anie.202508976}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508976}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solution-mediated photoreversible switch between 2D and 3D hydrogen-bonded organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Electrophotochemical radical relay for remote alkenylation of unactivated C(sp3)–H sites in alcohols. ANGEW, 64(32), e202508960. (www)

  @article{ , abstract = {The Mizoroki–Heck reaction is a powerful method for alkene formation from various molecules; however, its application has traditionally been limited to halogenated compounds. Accessing organic molecules with halogen atoms at specific positions in aliphatic systems is highly restricted, and their synthesis is extremely difficult. Therefore, achieving site-selective alkenylation of alkyl compounds at specific positions remains challenging. This paper presents a versatile redox-neutral method for the alkenylation of long-chain alkyl alcohols at unactivated δ-C(sp 3 )-H sites, enabling the construction of alkenols through electrophotochemical (EPC) cerium (Ce) catalysis with free alcohols. The method demonstrates excellent substrate compatibility, facilitating the use of both primary and secondary alcohols and enabling the successful synthesis of quaternary carbon alkenols. Mechanistically, cyclic voltammetry experiments reveal that the oxidative reaction is driven by electrochemical oxidation at the anode under applied potential. Additionally, styrene boronic acid remains unoxidized during the reaction, confirming a radical addition mechanism rather than a radical–radical coupling process. UV–vis experiments further demonstrate that the ligand not only activates the alkene boronic acid but also functions as a base to promote the ligand exchange between alcohol and Ce(IV)−Cl species.}, archive = {J_ANGEW}, author = {Zhaoliang Yang and Shuo Xu and Haiyan Du and Jiajun Li and Tianjiao Peng and Chunlei Liu}, doi = {10.1002/anie.202508960}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508960}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrophotochemical radical relay for remote alkenylation of unactivated C(sp3)–H sites in alcohols}, volume = {64}, year = {2025}, }
• (2025). Small molecule-induced alterations of protein polyubiquitination revealed by mass-spectrometric ubiquitome analysis. ANGEW, 64(32), e202508916. (www)

  @article{ , abstract = {Small molecules that alter protein ubiquitination are emerging as therapeutics due to their ability to modulate targets previously deemed undruggable. These compounds comprise PROTACs, molecular glue degraders, and DUB inhibitors, among others. However, methods for the proteome-wide monitoring of compound-induced changes in protein polyubiquitination, which may also detect non-degradative modifications, are lacking. Here, we report the utilization of polyubiquitin enrichment coupled to mass spectrometry to monitor small molecule-induced changes in cellular protein ubiquitination. We established enrichment through tandem ubiquitin binding entities (TUBEs) following semi-denaturing cell lysis and devised an elution protocol compatible with downstream LC-MS/MS analysis. We demonstrate the broad applicability of the workflow by assessing ubiquitination changes induced by a PROTAC, a p97 inhibitor, and deubiquitinase inhibitors. Application of the assay to compounds inhibiting the deubiquitinase USP7 revealed the induction of non-degradative ubiquitination on the E3 ligase UBE3A. Collectively, we established a versatile proteomics method to facilitate the direct investigation of cellular polyubiquitination, with high relevance for the identification and characterization of protein degraders, stabilizers, and other molecules with ubiquitin-mediated bioactivity.}, archive = {J_ANGEW}, author = {Siska Führer and Kai Gallant and Farnusch Kaschani and Markus Kaiser and Petra Janning and Herbert Waldmann and Malte Gersch}, doi = {10.1002/anie.202508916}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Small molecule-induced alterations of protein polyubiquitination revealed by mass-spectrometric ubiquitome analysis}, volume = {64}, year = {2025}, }
• (2025). “Gene-editing” design upgrades eutectic-polymer electrolytes with ultra-high li+ conductivity. ANGEW, 64(32), e202508857. (www)

  @article{ , abstract = {Deep eutectic polymer electrolytes (DEPEs) have emerged as highly promising next-generation electrolytes, offering unparalleled electrochemical performance and safety. Their excellence stems from a synergistic blend of the robust mechanical stability of solid polymer electrolytes and the exceptional interfacial wettability and superior thermal resilience of deep eutectic electrolytes. However, conventional DEPEs frequently exhibit suboptimal Li + conductivity due to strong coordination between Li + and oxygen-containing polymer moieties. Inspired by the concept of ‘gene-editing’ in biology, we propose a novel deep eutectic polymer electrolyte (GEPE) with precisely tailored molecular architectures This approach exploits the steric hindrance and electron-withdrawing inductive effects from isophorone diisocyanate-derived segments to reduce Li + -polymer interactions, thereby enabling an extraordinary ionic conductivity of 3.00 mS cm⁻¹ at 25 °C and a Li + transference number of 0.61. Remarkably, GEPE exhibits extraordinary cycling stability in Li||Li symmetric cells for over 3000 h, demonstrating dendrite-free Li metal deposition during prolonged cycling. Moreover, the assembled lithium metal batteries demonstrate exceptional electrochemical performance when incorporating diverse cathodes, including LiNi 0.5 Co 0.2 Mn 0.3 O 2 , LiNi 0.8 Co 0.1 Mn 0.1 O 2 , and LiFePO 4 . Notably, the Li|GEPE|LiFePO 4 cells achieve an impressive nearly 100% Coulombic efficiency and remarkable long-term stability over 10 000 cycles at 5C.}, archive = {J_ANGEW}, author = {Zhenghao Li and Hongyao Wang and Yun Zheng and Yanfei Zhu and Bingsen Qin and Zongtao Lu and Wei Yan and Jiujun Zhang}, doi = {10.1002/anie.202508857}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508857}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Gene-editing” design upgrades eutectic-polymer electrolytes with ultra-high li+ conductivity}, volume = {64}, year = {2025}, }
• (2025). Chemical bond covalency in superionic halide solid-state electrolytes. ANGEW, 64(32), e202508835. (www)

  @article{ , abstract = {Halide solid-state electrolytes (SSEs) are promising superionic conductors with high oxidative stability and ionic conductivity, making them attractive for all-solid-state lithium-ion batteries. However, most studies have focused on ion-stacking structures, overlooking the role of bond characteristics in ionic transport. Here, we investigate bond dynamics and the superionic transition (SIT) in bromide electrolyte, Li 3 InBr 6 , using synchrotron X-ray techniques and ab initio molecular dynamics (AIMD) simulations. We demonstrate that the SIT in halide SSEs is driven by a thermally induced transition in bonding character (ionic to covalent) rather than a change in crystal phase. AIMD simulations further reveal enhanced Li⁺ diffusion and collective anion motion at elevated temperatures. Expanding our study to Li 3 LnBr 6 (Ln = Gd, Tb, Ho, Tm, and Lu), we confirm the widespread occurrence of SIT in this material class, with Li 3 GdBr 6 exhibiting the highest ionic conductivity (5.2 mS cm −1 at 298 K). More importantly, the ionic-covalent transition is highly tunable through electrolyte modifications, such as cation/anion substitution and synthesis methods. Our findings provide a new perspective on ionic transport, highlighting the critical role of chemical bond characteristics in halide SSEs.}, archive = {J_ANGEW}, author = {Jiamin Fu and Han Su and Jing Luo and Xiaona Li and Jianwen Liang and Changhong Wang and Jung Tae Kim and Yang Hu and Feipeng Zhao and Shumin Zhang and Hui Duan and Xiaoge Hao and Weihan Li and Jian Peng and Jue Liu and Shuo Wang and Tsun-Kong Sham and Xueliang Sun}, doi = {10.1002/anie.202508835}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508835}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical bond covalency in superionic halide solid-state electrolytes}, volume = {64}, year = {2025}, }
• (2025). Radical-assisted nonradiative processes to couple photothermy and photosensitization for solar-driven water evaporation. ANGEW, 64(32), e202508821. (www)

  @article{ , abstract = {Nonradiative (NR) processes are pivotal in engineering materials with tailored properties for energy utilization. However, their intrinsic rapidity and competitiveness pose huge challenges in on-demand manipulation. Herein, radical-assisted multiple NR processes were achieved to couple photothermy and photosensitization based on a unique near-infrared-absorbing diradical-featured croconium (CR) dendrimer, CR-(DPA) 2 -OMe. This dendrimer is well-designed by the direct covalent linkage between the flexible dendritic diphenylamine (DPA) and rigid diradical-featured CR units. The intrinsic diradical characteristics promote internal conversions in company with intramolecular donor–acceptor interactions, and the hyperfine coupling effect between the dimeric radical-ion pair excitons and adjacent magnetic nuclei assists intersystem crossing. Besides, the abundant intramolecular motions from the twisted and flexible dendritic diphenylamine groups facilitate vibrational relaxation and electron transfer. These processes endow CR-(DPA) 2 -OMe with a photothermal conversion efficiency of 85.05% and superoxide anion generation capability under 808 nm laser irradiation. Thus, a water evaporation efficiency of 92.6% and antibacterial efficacy under one sunlight are obtained, comprehensively superior to previously reported organic small-molecule photothermal materials for solar-driven water evaporation. These findings highlight the importance of radicals in NR process manipulation, significantly boosting the development of organic functional materials with on-demand excited-state energy conversions.}, archive = {J_ANGEW}, author = {Liming Yang and Guan Wang and Yizhu Zhang and Ji Zhou and Ruonan Wu and Chaochao Qin and Qingda Chang and Chuang Zhang and Shun Duan and Xinggui Gu}, doi = {10.1002/anie.202508821}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508821}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radical-assisted nonradiative processes to couple photothermy and photosensitization for solar-driven water evaporation}, volume = {64}, year = {2025}, }
• (2025). In Situ/Operando probing of dynamic phase structures of alumina-supported ultrasmall copper-gold alloy nanoparticles under reaction conditions. ANGEW, 64(32), e202508735. (www)

  @article{ , abstract = {The ability to control phase structures and surface sites of ultrasmall alloy nanoparticles under reaction conditions is essential for preparing catalysts by design. This is, however, challenging due to limited understanding of the atomic-scale phases and their correlation with the ensemble-averaged structures and activities of catalysts during catalytic reactions. We reveal here a dynamic structural stability of alumina-supported ultrasmall and equiatomic copper-gold alloy nanoparticles under reaction conditions as a model system in the in situ/operando study. In situ atomic-scale morphological tracking under oxygen reveals temperature-dependent dynamic crystalline-amorphous dual-phase structures, showing dynamic stability over an elevated temperature range. This atomic-scale dynamic phase stability coincides with a “conversion plateau” observed for carbon monoxide oxidation on the catalyst. It is substantiated by the stable lattice ordering/disordering structures and surface sites with oscillatory characteristics shown by operando ensemble-average structural tracking of the catalyst during the oxidation reaction. The understanding of the atomic-scale dynamic phase structures in correlation with the ensemble-average dynamic ordering/disordering phase structures and surface sites provides fresh insights into the unique synergy of the supported alloy nanoparticles. This understanding has implications for the design and structural tuning of active and stable ultrasmall alloy catalysts under elevated temperatures.}, archive = {J_ANGEW}, author = {Han-Wen Cheng and Jing Li and Shiyao Shan and Xiaowei Lv and Guanyu Chen and Merry Madiou and Dong Dinh and Seyed Danial Mousavi and Zhi-Peng Wu and Shan Wang and Yazan Maswadeh and Valeri Petkov and Susan Lu and Ke Pei and Wenbin You and Renchao Che and Chuan-Jian Zhong}, doi = {10.1002/anie.202508735}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508735}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In Situ/Operando probing of dynamic phase structures of alumina-supported ultrasmall copper-gold alloy nanoparticles under reaction conditions}, volume = {64}, year = {2025}, }
• (2025). Accelerated exciton dissociation and charge transfer via third-motif engineered conjugated polymers for photocatalytic circulation-flow synthesis of H2O2. ANGEW, 64(32), e202508690. (www)

  @article{ , abstract = {Achieving effective exciton dissociation and charge transport in linear polymer photocatalysts for H 2 O 2 photosynthesis remains a formidable challenge. Herein, we fabricated three-motif cross-linked polymers by rationally introducing a third functional component into a two-motif linear polymer, which were employed for circulation-flow photocatalytic H 2 O 2 production. By strategically modulating the third component, we precisely tuned the electronic structure, significantly lowering exciton binding energy and enlarging the molecular dipole moment. Compared to the original linear configuration, the resulting cross-linked structure creates multidirectional electron transport channels. Combined experimental and calculation investigations demonstrate that these synergistic effects collectively promote exciton dissociation and intramolecular electron transfer. PAQ-TABPB photocatalyst with optimized third-motif accelerates oxygen-to-superoxide radical transformation by lowering the *OOH binding energy, thereby facilitating the two-step single-electron oxygen reduction pathway, attaining an exceptional H 2 O 2 production rate of 3351 µmol g −1 h −1 . Notably, we constructed a circulation-flow reactor for the photocatalytic synthesis of H 2 O 2 . Benefiting from improved gas-liquid mass transfer and efficient light irradiation, this high-speed flow system achieved a 5.2-fold increase in H 2 O 2 production compared to a conventional batch reactor under the light intensity of 27 mW cm −2 , reaching an accumulated yield of 3125 µmol g −1 with stable recyclability. This work highlights the potential of multi-component polymeric photocatalysts and circulation-flow reactors for H 2 O 2 photosynthesis.}, archive = {J_ANGEW}, author = {Wenwen Chi and Jiale Wu and Yuming Dong and Jie Wu and Yongfa Zhu}, doi = {10.1002/anie.202508690}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508690}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerated exciton dissociation and charge transfer via third-motif engineered conjugated polymers for photocatalytic circulation-flow synthesis of H2O2}, volume = {64}, year = {2025}, }
• (2025). Thermally activated sensitized fluorescence enables efficient carbon quantum dot-based electroluminescent LEDs with current efficiency of 31 cd a−1. ANGEW, 64(32), e202508650. (www)

  @article{ , abstract = {Carbon quantum dots (CQDs) are gaining increasing attention as eco-friendly alternatives to conventional heavy-metal-based QDs for full-color displays and solid-state lighting. However, the performance of CQD-based light-emitting diodes (CQD-LEDs) remains significantly lower than their heavy-metal counterparts, primarily due to the substantial energy loss from triplet excitons during electrical excitation and the reduced quantum yield (QY) in solid films. Here, we present the demonstration of bright and efficient electroluminescent LEDs based on a thermally activated sensitized fluorescence (TSF) mechanism, employing a new class of solid-state emissive (SSE) CQDs that exhibit efficient orange emission in the solid state and bright green emission when doped into host materials, with a QY exceeding 80%. By employing thermally activated delayed fluorescence (TADF) materials as both hosts and sensitizers, along with highly efficient CQDs as dopants, we significantly enhance exciton utilization through effective Förster energy transfer from sensitizers to CQDs. This strategy results in bright, efficient green CQD-LEDs, achieving a maximum luminance of approximately 16,000 cd m −2 and a record-high current efficiency of 31 cd A −1 . This work provides a straightforward and universal strategy for creating efficient SSE CQD-LEDs using the TSF strategy.}, archive = {J_ANGEW}, author = {Qian Teng and Qinghua Tan and Mengyue Hou and Fanglong Yuan}, doi = {10.1002/anie.202508650}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508650}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermally activated sensitized fluorescence enables efficient carbon quantum dot-based electroluminescent LEDs with current efficiency of 31 cd a−1}, volume = {64}, year = {2025}, }
• (2025). Enantioconvergent cobalt-catalyzed hydroalkylation for the construction of fluoro, chloro, and trifluoromethyl stereogenic centers. ANGEW, 64(32), e202508637. (www)

  @article{ , abstract = {Organic compounds containing a chiral, halogenated aliphatic carbon center are useful in medicinal chemistry, but their enantioselective synthesis remains difficult. Here, we develop a general approach to access these compounds through cobalt-catalyzed hydroalkylation of allenes and alkenes with dihaloamides. The reactions of allenes and terminal alkenes lead to alkylation only at the terminal position. In contrast, the reactions of internal alkenes occur via chain-walking and alkylation at the terminal position. These reactions operate by enantioconvergent transformation of racemic secondary alkyl halides to give enantio-enriched products. The method exhibits broad scope and high chemo, regio, and enantioselectivity. The synthetic utility of the method is demonstrated by further transformations of the products as well as the application in late-stage functionalization of complex substrates.}, archive = {J_ANGEW}, author = {Uttam Dhawa and Xile Hu}, doi = {10.1002/anie.202508637}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioconvergent cobalt-catalyzed hydroalkylation for the construction of fluoro, chloro, and trifluoromethyl stereogenic centers}, volume = {64}, year = {2025}, }
• (2025). Atomically engineered acridine derivatives serve as metal-free and self-sensitized catalysts for solar-driven CO2 to formic acid with high-efficiency and near-perfect selectivity. ANGEW, 64(32), e202508620. (www)

  @article{ , abstract = {Achieving efficient and selective light-driven CO 2 conversion to formic acid is a significant scientific challenge, particularly when utilizing purely organic, metal-free, and earth-abundant element-based molecule photocatalysts. Herein, we first reported the discovery of acridine derivatives (DADN , PXZN , and PTZN ) as new-type, metal-free, self-sensitized molecule catalysts that enabled exceptional performance in solar-driven CO 2 reduction to formic acid. Notably, the atomically engineered sulfur-containing heterocycle PTZN demonstrated unprecedented formate yield rate of 47.8 mmol g −1 h −1 and >99% selectivity in a photocatalytic system using 1,3-dimethyl-1 H -benzo[ d ]imidazol-3-ium (BI + ) as proton and electron relay. The superior activity of PTZN was revealed to arise from its synergistic combination of strong CO 2 -binding affinity (−0.195 eV), prolonged charge-separated states (11 ns), and robust CO 2 electronic coupling (2.51 eV). Comprehensive studies including in situ electron spin resonance, in situ infrared, and transient absorption spectroscopy unambiguously unveiled a direct single electron transfer process from the excited singlet-state acridine derivatives to CO 2 , generating CO 2 ·− . Moreover, a hydrogen atom transfer process utilizing in situ generated BIH as a hydrogen atom carrier enabled the conversion of CO 2 ·− to formic acid. This work establishes the first demonstration of a sequential proton–electron transfer mechanism in acridine-based photocatalysis, resolving long-standing challenges in proton and electron delivery during CO 2 activation.}, archive = {J_ANGEW}, author = {Xianjun Yin and Kefan Zhang and Cui Xu and Qiang Gao and Mengyang Zhang and Xu-Bing Li and Hui-Qing Peng and Chen-Ho Tung and Li-Zhu Wu and Bin Liu}, doi = {10.1002/anie.202508620}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508620}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomically engineered acridine derivatives serve as metal-free and self-sensitized catalysts for solar-driven CO2 to formic acid with high-efficiency and near-perfect selectivity}, volume = {64}, year = {2025}, }
• (2025). The doping effects on the NIR emission enhancement of gold nanoclusters and the application in efficient NIR-OLED. ANGEW, 64(32), e202508578. (www)

  @article{ , abstract = {Metal nanoclusters (NCs) have emerged as promising near-infrared (NIR) emissive materials. A series of highly red/NIR luminescent Au–Cu nanoclusters have been synthesized, Au 22- x Cu x ( t BuC 6 H 4 C≡C) 18 ( x = 0–6) ( Au 22- x Cu x ). Compared with the parental cluster Au 22 ( t BuC 6 H 4 C≡C) 18 ( Au 22 ), doping effects have been clearly established: the more the amount of doping Cu, the higher photoluminescence quantum yield (PLQY). Remarkable solutions for NIR emission under ambient conditions are found with Au 19 Cu 3 and Au 17.1 Cu 4.9 , and the PLQYs at ∼710 nm are ∼55% and ∼72%, respectively. The study on excited state dynamics of these clusters reveals that the more copper atoms doped, the slower nonradiative decay and the faster intersystem crossing rate, the higher PLQY. Surprisingly, an external quantum efficiency (EQE) of ∼15.43% is achieved from a NIR-OLED with Au 16 Cu 6 as the emitting layer, showing the prospect of metal NCs in potential applications for NIR-OLED.}, archive = {J_ANGEW}, author = {Wen-Wen Jia and Yu Dai and Lin-Lin Zeng and Zhen-Chao Long and Wan-Qi Shi and Meng Zhou and Juan Qiao and Quan-Ming Wang}, doi = {10.1002/anie.202508578}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The doping effects on the NIR emission enhancement of gold nanoclusters and the application in efficient NIR-OLED}, volume = {64}, year = {2025}, }
• (2025). Highly efficient singlet oxygen production in a cascade photoelectrocatalytic system for water decontamination. ANGEW, 64(32), e202508548. (www)

  @article{ , abstract = {Singlet oxygen (¹O₂) demonstrates great potential for selective wastewater detoxification, which raises the appeal to achieve a controllable, mild, and efficient generation of this reactive species for water decontamination. Herein, we present a novel cascade photoelectrocatalytic (PEC) system operated via the interaction between the photoanodic and cathodic reactions without the addition of chemical precursors, realizing highly efficient ¹O₂ production (79.7 µmol L −1 min −1 ) and low energy consumption (0.052 kWh m −3 -log) for antibiotic degradation. The enhanced 1 O 2 production is proven to benefit from the synergistic effect of multiple activation pathways under PEC excitation. With the combined action of both the built-in electric field and external electric field, the holes in the Z-scheme heterojunction photoanode are maximally retained, and electrons are transferred to cathode to undergo the oxygen reduction reaction (ORR), leading to the production of the crucial reactive oxygen species as intermediates. The occurrence of a cascade reaction is initiated by electrocatalytic 2e − ORR on the cathode and terminated by superoxide species oxidation by holes on the photoanode. The hole-involved 1 O 2 generation pathway circumvents the thermodynamically unfavorable process of traditional 1 O 2 generation. This work highlights a new PEC route for highly efficient 1 O 2 generation, making it a potential application in more effective environmental remediation.}, archive = {J_ANGEW}, author = {Ruiheng Liang and Shuaishuai Li and Xiuwu Zhang and Zhongzheng Hu and Huizhong Wu and Jiangli Sun and Ge Song and Jingyang Liu and Yandong Chai and Ignasi Sirés and Minghua Zhou}, doi = {10.1002/anie.202508548}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508548}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient singlet oxygen production in a cascade photoelectrocatalytic system for water decontamination}, volume = {64}, year = {2025}, }
• (2025). Multivariate MOF hollow fiber membranes with precision-tuned subnanometer channels toward aromatic hydrocarbon separation. ANGEW, 64(32), e202508510. (www)

  @article{ , abstract = {Metal-organic framework (MOF) membranes exhibit great potential for molecular separations, but it remains a considerable challenge to achieve precise pore aperture regulation, typically requiring the synthesis of distinct MOF structures for each targeted separation. Herein, the first multivariate MOF (MTV-MOF) hollow fiber membranes with precision-tuned subnanometer channels have been fabricated by leveraging the heterogeneous spatial distribution of ligands, where reduced coordination energy barriers drive the formation of alternating narrow (local-path limited) and wide channels, simultaneously addressing the critical permeability-selectivity trade-off in membrane separations. The alternating narrow-wide channel architecture has been systematically investigated through combined density functional theory calculation, molecular dynamics simulation and mathematical modeling, with direct experimental validation provided by low-dose high-resolution scanning transmission electron microscopy and quantitative adsorption analysis. These MTV-MOF membranes demonstrated the ability to selectively separate aromatic hydrocarbons achieving highly selective separation while reduce the molecular transport barriers, offering significant potential for industrial separation processes.}, archive = {J_ANGEW}, author = {Zhen Chen and Bin Li and Ying Liu and Zi-Meng Xu and Xiao-Feng Zhong and Pan-Pan Zhang and Ling-Mei Liu and Yi Li and Ming Xue and Xiao-Ming Chen}, doi = {10.1002/anie.202508510}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508510}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multivariate MOF hollow fiber membranes with precision-tuned subnanometer channels toward aromatic hydrocarbon separation}, volume = {64}, year = {2025}, }
• (2025). Intramolecular dual donor-acceptor featured covalent organic frameworks enabled by gating effects for ultra-stable na-metal batteries. ANGEW, 64(32), e202508503. (www)

  @article{ , abstract = {Sodium metal batteries (SMBs) face severe challenges of uncontrolled sodium dendrite growth and interfacial instability. Herein, guided by theoretical predictions, a distinct locally polarized covalent organic framework (TB-Br-COF) was synthesized and employed as a Na⁺ transport accelerator to promote uniform Na deposition. TB-Br-COF excited the gating effect (a high gating ratio of 23.1) through electronic response to accomplish the separation of Na + from the electrolyte solvent via the sodiophilic sites (-O-C═C units, C═N linkages, C─Br bonds, and aromatic rings). Simultaneously, it synergistically induced two electron migration routes based on the dual donor-acceptor (linkages and linkers) structures, thereby enhancing both electron separation efficiency and Na + cations’ transport. Benefiting from that, the TB-Br-COF-based symmetric battery achieved an ultra-stable operating time of 1000 h at 1 mA cm −2 with 1 mAh cm −2 . Moreover, the full battery based on the modified Na@TB-Br-COF electrode and the carbon-coated Na 3 V 2 (PO 4 ) 3 /C (NVP/C) demonstrated high compatibility and good cycling stability. Theoretical calculation and in situ spectra measurements have jointly proved the molecular stability and mechanical robustness. Therefore, this investigation unveils an unconventional method for creating COF-based protective layers for the practical SMBs.}, archive = {J_ANGEW}, author = {Haichao Wang and Xiao-Meng Lu and Yiwen Sun and Yi Xu and Weiwei Sun and Liping Lv and Shuangqiang Chen and Yong Wang}, doi = {10.1002/anie.202508503}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508503}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intramolecular dual donor-acceptor featured covalent organic frameworks enabled by gating effects for ultra-stable na-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Mn/TiO2 catalysts for the high-yield partial oxidation of methane with molecular oxygen to a methyl ester. ANGEW, 64(32), e202508465. (www)

  @article{ , abstract = {We synthesize and evaluate a diverse range of Mn/TiO 2 catalysts with varying physical and redox properties for the methane-to-methyl-ester reaction using molecular oxygen in a diluted acid medium (10 wt% trifluoroacetic acid). Despite initial differences in manganese distributions, nearly all catalysts are active under the reaction conditions, and the degree of activity is partially correlated to catalyst reducibility in hydrogen temperature programmed reduction and manganese K-edge X-ray absorption spectroscopy. Under methane-limited conditions, exceptionally high product yields of up to ca. 30% are obtained. Catalysts synthesized with a co-precipitation method demonstrate the highest productivity (up to 1440 µmol g cat −1 h −1 ) in methane-excess conditions, and their full activity can be restored in a subsequent reaction cycle upon a mild thermal treatment. Under high conversion conditions, the co-precipitated catalyst can achieve methane-based product yields of ca. 15%. The performance of Mn/TiO 2 catalysts using molecular oxygen under less corrosive conditions surpasses that of other heterogeneous catalysts.}, archive = {J_ANGEW}, author = {Andrea N. Blankenship and Alexandru-Tudor Toderașc and Vladimir Paunović and Jeroen A. van Bokhoven}, doi = {10.1002/anie.202508465}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508465}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mn/TiO2 catalysts for the high-yield partial oxidation of methane with molecular oxygen to a methyl ester}, volume = {64}, year = {2025}, }
• (2025). Visible light-driven benzaldoxime synthesis by glutathione-modified CdS quantum dots. ANGEW, 64(32), e202508442. (www)

  @article{ , abstract = {Inspired by the secondary coordination sphere of nitrite reductase, we report herein the first photocatalytic benzaldoxime synthesis from NO x − ( x = 2, 3) and benzyl alcohol. Different from introducing co-catalysts, the integration of glutathione (GSH) relay with CdS quantum dots (QDs) can effectively mediate hole transfer and facilitate selective benzyl alcohol oxidation to benzaldehyde. At the same time, GSH assists continuous proton transfer to promote selective NO x − reduction and form NH 2 OH in situ. As a result, the synergic C–N coupling delivers a series of benzyl oximes from NO x − and benzyl alcohols with excellent yield and selectivity. Benzaldoxime synthesis proceeds at a rate of 18.7 mmol g cat −1 h −1 and TON of 52,875, accomplishing 90.6% benzyl alcohol conversion and 72.3% benzaldoxime yield, which is comparable to the best records for electrocatalytic benzaldoxime synthesis. The excellent long-term recyclability and scaled reaction to produce 0.58 g benzaldoxime with a yield of 41% demonstrate efficient, atom-economic, and step-economic photocatalytic oxime synthesis via selective C–N coupling from abundant resources.}, archive = {J_ANGEW}, author = {Jia-Hao Li and Shu-Lin Meng and Xin-Ling Zhang and Yu-Lin Yin and Chen-Ho Tung and Li-Zhu Wu}, doi = {10.1002/anie.202508442}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508442}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible light-driven benzaldoxime synthesis by glutathione-modified CdS quantum dots}, volume = {64}, year = {2025}, }
• (2025). Synthesis of Bicyclo[1.1.1]Pentane Z-substituted enamides, enol ethers, and vinyl sulfides using iodine (III) reagents. ANGEW, 64(32), e202508404. (www)

  @article{ , abstract = {Bicyclo[1.1.1]pentanes (BCPs) are well-studied bioisosteres for para -substituted benzene rings, and numerous methods for synthesizing 1,3-difunctionalized BCPs have been developed. However, synthetic approaches to access vinyl BCP motifs remain limited, with only few reports on the synthesis of BCP-olefins bearing heteroatom substituents. Herein, we present the synthesis of BCP-substituted enamides, enol ethers, and vinyl sulfides through the sequential functionalization of ethynylbenziodoxolone (EBX) reagents containing a BCP scaffold. Stereoselective addition of a nucleophile generates heteroatomic Z-vinylbenziodoxolone (VBX) reagents. The hypervalent iodine substituent of the VBX reagents serves then as a versatile platform for further arylation, vinylation, and trifluoromethylation. This method provides a modular synthesis of previously inaccessible heteroatom-substituted vinyl BCPs.}, archive = {J_ANGEW}, author = {Najung Lee and Jonas Dechent and Elija Grinhagena and Jerome Waser}, doi = {10.1002/anie.202508404}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508404}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of Bicyclo[1.1.1]Pentane Z-substituted enamides, enol ethers, and vinyl sulfides using iodine (III) reagents}, volume = {64}, year = {2025}, }
• (2025). Electrochemical allene C─H functionalization via carbanion sampling. ANGEW, 64(32), e202508369. (www)

  @article{ , abstract = {Functionalization of C─H bonds represents a direct and practical avenue to upgrade simple organic molecules to value-added products, whereas the reaction selectivity is largely governed by the acidity and bond dissociation energy (BDE) of C─H bonds. Developing a novel strategy to break these constraints is highly desirable, as it would open a new horizon for conventionally challenging molecules. Herein, we disclosed a carbanion sampling strategy that enables unconventional selectivity in the allene C(sp 2 )─H functionalization harnessing chromium-catalyzed hydrogen evolution. The electrochemical protocol provides in situ access to diverse allene carbanions and facilitates a dynamic carbanion sampling process to give thermodynamically unfavored products. 1,3-Disubstituted allenes were precisely functionalized at the less acidic and stronger C(sp 2 )─H site to yield abnormal site-selective allene products, while the 1,1-substituted allenes proceeded isomerization to deliver functionalized alkynes. All of the products presented in this work are unprecedented and exhibit remarkable versatility in late-stage derivatization. The superiority of the carbanion sampling strategy was demonstrated in the convergent synthesis of functionalized allenes from alkyne or mixed substrates. More importantly, we conducted a series of density functional theory (DFT) calculations and control experiments to rationalize the unconventional selectivity.}, archive = {J_ANGEW}, author = {Jiayi Feng and Yuhang Xia and Mingyu Shen and Junwei Wang and Weigang Fan and Sheng Zhang and Man-Bo Li}, doi = {10.1002/anie.202508369}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508369}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical allene C─H functionalization via carbanion sampling}, volume = {64}, year = {2025}, }
• (2025). Photo-tuned solid-liquid transition of azo-grafted poly(thioctic acid) with ultrahigh photothermal conversion efficiency. ANGEW, 64(32), e202508314. (www)

  @article{ , abstract = {Functional materials with photo-regulated solid-liquid transition have garnered significant attention and found extensive applications across cutting-edge domains. However, previous photo-liquefiable behaviors of azopolymers are usually induced through UV light, which may damage the performances of the materials and is also harmful to human health. Here, a novel azopolymer (Azo-PTA) was fabricated via the ring-opening copolymerization of thioctic acid (TA) and azobenzene-modified thioctic acid (Azo-TA). Interestingly, Azo-PTA could undergo a reversible solid-liquid transition under green light irradiation. The phase transition process of Azo-PTA was investigated systematically through various experimental and measurement methods. The results demonstrated that the solid-liquid transition of Azo-PTA was ascribed to the photothermal effect rather than the photochemical process. The light-to-heat conversion efficiency of Azo-PTA was as high as 84.9%, and the temperature could increase to above 90 °C within 30 s of green light irradiation. Consequently, azopolymers with green light-regulated solid-liquid transition behaviors were successfully achieved. Moreover, several cutting-edge applications of Azo-PTA were explored, including photo-switchable adhesion, self-healing coating, and smart window. Our finding thus opens up a new platform for the fabrication of azopolymers with visible light-regulated solid-liquid transition.}, archive = {J_ANGEW}, author = {Jian Zhou and Ning Zhou and Wen Xu and Zhehao Qian and Zhifeng Dai and Jianquan Xu and Jian Chen and Yubing Xiong}, doi = {10.1002/anie.202508314}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-tuned solid-liquid transition of azo-grafted poly(thioctic acid) with ultrahigh photothermal conversion efficiency}, volume = {64}, year = {2025}, }
• (2025). An atomically precise alkynyl-functionalized Silver–Polyoxotungstate nanocluster with sandwiched three-layer {Ag13}13+ cluster architecture and enhanced antitumor activity. ANGEW, 64(32), e202508288. (www)

  @article{ , abstract = {The synthesis of atomically precise, structurally well-defined polyoxometalate (POM)-stabilized silver clusters with accessible silver surfaces remains a significant challenge. Here, we report an alkynyl-functionalized silver–POM hybrid nanocluster, [( n -Bu) 4 N] 7 [(C 6 H 9 ) 6 (PW 11 O 39 ) 2 Ag 13 ] ( (PW 11 ) 2 -Ag 13 ), which comprises of a distinctive homovalent three-layer {Ag 13 } 13+ cluster. This architecture yields a lower HOMO − LUMO energy gap of 1.93 eV, compared to the precursor [PW 11 O 39 ] 7− (2.74 eV). Structural characterization and theoretical calculations confirm that the lacunary [PW 11 O 39 ] 7− and alkynyl units direct the formation of the atomically precise {Ag 13 } 13+ cluster, preventing undesirable silver aggregation while maintaining exposed silver surfaces that are crucial for catalytic activity. The synergistic redox capabilities of the POM and silver components enhance the redox reactivity of (PW 11 ) 2 -Ag 13 , promoting efficient reactive oxygen species (ROS) generation via a Fenton-like mechanism. Additionally, biological evaluations further reveal that (PW 11 ) 2 -Ag 13 exhibits significantly superior antitumor activity than [PW 11 O 39 ] 7− , primarily through ROS-induced apoptosis facilitated by the active silver cluster sites. These findings highlight the potential of silver cluster-POM hybrids as promising candidates for anticancer therapeutic applications.}, archive = {J_ANGEW}, author = {Teng Zhang and Ying Feng and Cong-Qiao Xu and Shina Quek and Junqiao Wang and Jun Li and Ying Tan and Lixin Wu and Cheuk-Wai So}, doi = {10.1002/anie.202508288}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508288}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An atomically precise alkynyl-functionalized Silver–Polyoxotungstate nanocluster with sandwiched three-layer {Ag13}13+ cluster architecture and enhanced antitumor activity}, volume = {64}, year = {2025}, }
• (2025). Cobalt-oxygen coordination steering *NO hydrogenation in nitrate electroreduction. ANGEW, 64(32), e202508227. (www)

  @article{ , abstract = {Understanding the hydrogenation behavior of *NO during electrochemical nitrate reduction reaction (NO 3 RR) is essential for designing catalysts with high selectivity toward ammonia (NH 3 ) and valuable intermediates like hydroxylamine. Spinel cobalt oxides (Co 3 O 4 ) are promising NO 3 RR electrocatalysts, yet the exact *NO hydrogenation mechanism remains unclear. Here, we integrate theoretical calculations and systematic experiments to reveal that the hydrogenation pathway is dictated by the coordination environment, which can be tuned via crystal facet engineering. Co 3 O 4 nanoparticles enriched with (111) facets (o-Co 3 O 4 ) and (100) facets (c-Co 3 O 4 ) were synthesized to expose 4- and 6-coordinated Co sites, respectively. Theoretical results show that o-Co 3 O 4 favors nitrogen-site hydrogenation ( ), while c-Co 3 O 4 promotes oxygen-site hydrogenation ( ), leading to distinct rate-determining steps. This selectivity is experimentally supported by in situ spectroscopy, which detects the *NH 2 OH intermediate exclusively on o-Co 3 O 4 . Consequently, o-Co 3 O 4 achieves superior NO 3 RR performance, with a Faradaic efficiency of 99.4% and an NH 3 yield rate of 12.8 mg h −1 cm −2 at −0.4 V. This work uncovers the coordination-governed mechanism of *NO hydrogenation and establishes facet engineering as an effective strategy for directing reaction pathways in NO 3 RR.}, archive = {J_ANGEW}, author = {Shuai Niu and Yanqiu Wu and Jiawei Wang and Jinxin Gu and Xiao-Zhi Liu and Juan Zhang and Liang Chen and Jefferson Zhe Liu and Wen-Jie Jiang and Jin-Song Hu and Xu Wu}, doi = {10.1002/anie.202508227}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508227}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-oxygen coordination steering *NO hydrogenation in nitrate electroreduction}, volume = {64}, year = {2025}, }
• (2025). 3D-printed COF/Zeolite composites for augmented photocatalytic hydrogen peroxide production. ANGEW, 64(32), e202508226. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs), characterized by high porosity and fine-tuned structures, are promising photocatalysts for hydrogen peroxide (H 2 O 2 ) production. However, their hydrophobic nature restricts the mass transfer in water, presenting challenges in achieving high performance. Coupling COFs with hydrophilic zeolites can potentially advance H 2 O 2 production, yet integrating these two distinct types of porous materials is challenging. Herein, we first applied 3D printing technology to fabricate COF/zeolite composite catalysts, which enabled superior photosynthesis of H 2 O 2 . By precisely optimizing binders and prepolymerization conditions, homogeneous inks composed of zeolite nanocrystals and initial polymeric precursors were prepared with appropriate rheology for 3D printing. The resultant monolith with honeycomb-like open-channels was favorable for the in-situ growth and crystallization of COF by facilitating the efficient molecular transfer of condensing agents and large covalent segments during solvothermal post-treatment. Mechanistic studies indicated that introducing zeolites enhanced the hydrophilicity and O 2 affinity within the composite, favoring the oxygen reduction reaction pathway. Consequently, the photosynthesis of H 2 O 2 by the COF/zeolite composite was markedly improved by 52% compared to the bare COFs. This work provides a facile way to integrate COFs and zeolites by 3D printing, which may open diverse applications of such composites by taking advantage of both merits.}, archive = {J_ANGEW}, author = {Jingyi Feng and Yingzhen Wei and Xiao Li and Qifei Wang and Bolun Wang and Yunyu Guo and Binyao Feng and Enquan Jin and Jihong Yu}, doi = {10.1002/anie.202508226}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508226}, shortjournal = {Angew. Chem. Int. Edit.}, title = {3D-printed COF/Zeolite composites for augmented photocatalytic hydrogen peroxide production}, volume = {64}, year = {2025}, }
• (2025). Interfacial-confined oxygen vacancy clusters in ZrO2-supported In2O3-x catalysts boost methanol production from CO2. ANGEW, 64(32), e202508091. (www)

  @article{ , abstract = {Oxygen vacancies (V O ) play a vital role in catalytic reactions. Tuning the V O structures beyond its density is of great significance for optimizing catalytic performance, but remains challenging due to uncontrolled reduction and its poor stability under reaction conditions. Here, we report that the integration of quantum size effect for enhanced In 2 O 3 reducibility with strong In–O–Zr interfacial confinement for high stability enables the creation of stable large-size V O clusters (e.g., trimers, tetramers, and larger) on ZrO 2 -supported monolayer In 2 O 3- x nano-islands with high density without overreduction to metallic indium. In the CO 2 hydrogenation reaction, the ZrO 2 -supported monolayer In 2 O 3- x catalyst with V O clusters exhibits a considerably higher intrinsic activity for methanol production than that of bulk In 2 O 3 with single V O sites. Further addition of Pd onto these monolayer In 2 O 3- x with enriched V O clusters allows achieving an unprecedentedly high methanol space-time yield of 46.6 mmol MeOH ·g cat −1 h −1 at 270 °C along with long-term stability for at least 200 h, surpassing all In 2 O 3 -based catalysts reported to date.}, archive = {J_ANGEW}, author = {Lulu Xu and Qi Wang and Qingqing Gu and Shang Li and Yuxing Xu and Hao Chen and Hongjun Zhang and Bangjiao Ye and Jiafu Chen and Hanbao Chong and Jing Zhou and Xinyu Liu and Zhihu Sun and Shiqiang Wei and Bing Yang and Xiang-Kui Gu and Hengwei Wang and Junling Lu}, doi = {10.1002/anie.202508091}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508091}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial-confined oxygen vacancy clusters in ZrO2-supported In2O3-x catalysts boost methanol production from CO2}, volume = {64}, year = {2025}, }
• (2025). Intracellular CO2 capture triggered outperforming biocatalytic production of selective acetic acid and biohydrogen housing in porous-organic-nanofiber. ANGEW, 64(32), e202508070. (www)

  @article{ , abstract = {The increasing concentration of atmospheric carbon dioxide (CO₂) necessitates innovative biocatalytic strategies for its utilization in sustainable chemical production. This study introduces a novel electrofermentation (EF) platform integrating polycarbazole-based porous organic polymer ( VJ-POP )-coated electrodes to enhance selective acetic acid (AA) biosynthesis by Bacillus subtilis . Impressive high surface area and tailored porosity facilitate efficient CO₂ capture, modulate intracellular metabolic fluxes, and improve electron transfer, thereby driving product specificity. In the bioreactor equipped with VJ-POP , AA production reached 2.11 g L −1 with a yield of 0.48 g g −1 , achieving 71% of the theoretical maximum without genetic modifications. The process also resulted in enriched biohydrogen content (52%) in the biogas (H 2 + CO 2 ) composition, highlighting the synergistic effect of VJ-POP on CO₂ sequestration and microbial metabolism. Gene expression analysis revealed significant upregulation of ackA (acetate kinase) and pdhA (pyruvate dehydrogenase), while buk (butyrate kinase) was downregulated, ensuring metabolic selectivity toward AA. Cyclic voltammetry and impedance analysis unambiguously confirmed an interesting phenomenon of enhanced electron transfer and reduced charge-transfer resistance in VJ-POP- assisted systems. Computational analysis using density functional theory (DFT) revealed stronger binding energy for CO 2 (−17.4 kJ mol −1 ) compared to H 2 (−2.5 kJ mol −1 ), driven by a mix of van der Waals and weak electrostatic interactions for CO 2 versus solely weak van der Waals-based physisorption for H 2 . This pioneering approach with unique investigation results presents a scalable and sustainable biocatalytic framework for CO₂ valorization, bridging material science and microbial electrochemical systems for selective AA and enhanced biohydrogen production.}, archive = {J_ANGEW}, author = {Nitumani Das and Triya Mukherjee and Chitra Sarkar and Ratul Paul and Duy Quang Dao and S. Venkata Mohan and John Mondal}, doi = {10.1002/anie.202508070}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intracellular CO2 capture triggered outperforming biocatalytic production of selective acetic acid and biohydrogen housing in porous-organic-nanofiber}, volume = {64}, year = {2025}, }
• (2025). Mechanochemistry-driven borrowing hydrogen processes for ru-catalyzed N-alkylation: A pathway to enhanced sustainability and efficiency. ANGEW, 64(32), e202508050. (www)

  @article{ , abstract = {This study presents the first mechanochemical borrowing hydrogenation (BH) strategy, offering a direct and efficient route to N -alkylated amines and heterocycles. This solvent-free approach overcomes many challenges associated with conventional solution-based syntheses, such as toxic reagents, inert atmospheres, high temperatures, lengthy reaction times, excessive catalyst loadings, and the use of solvents. By applying this method under mechanochemical conditions and employing a readily available ruthenium-based catalyst, we achieved high conversions of a diverse set of primary amines and alcohols into N -alkylated amines. Furthermore, kinetic isotope effect ( KIE ) studies and Hammett analyses provided key insights into the underlying reaction mechanism. Ultimately, this protocol expands synthetic possibilities by facilitating the preparation of heterocycles.}, archive = {J_ANGEW}, author = {Sourav Behera and Dipak J. Fartade and Rita Mocci and Michela Matta and Lidia De Luca and Andrea Porcheddu}, doi = {10.1002/anie.202508050}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202508050}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanochemistry-driven borrowing hydrogen processes for ru-catalyzed N-alkylation: A pathway to enhanced sustainability and efficiency}, volume = {64}, year = {2025}, }
• (2025). Bypassing in situ CO poisoning in furfural conversion: Electron-deficient pd single-atom alloys enable one-step selective synthesis of tetrahydrofuran. ANGEW, 64(32), e202507984. (www)

  @article{ , abstract = {The one-step conversion of biomass-derived furfural (FUR) to tetrahydrofuran (THF) via combining decarbonylation and hydrogenation offers a sustainable alternative to the industrial Reppe process, while the selectivity control remains a significant challenge. Herein, we identify carbon monoxide (CO), in situ generated during FUR decarbonylation, as a major hindrance, significantly inhibiting subsequent furan hydrogenation. To overcome this limitation, a zeolite-encapsulated Pt 1 Pd single-atom alloy (SAA) catalyst, namely Pt 10 Pd 90 @S-1, is designed, which effectively mitigates CO poisoning and enables efficient FUR conversion to THF, achieving 100% FUR conversion and >93% THF selectivity with good long-term stability (∼100 h)—among the highest values reported to date. Mechanistic studies reveal that electron-deficient Pd species adjacent to single Pt atoms in Pt 10 Pd 90 @S-1 significantly enhance H 2 activation and furan adsorption, enabling efficient hydrogenation at both the C α and C β positions of furan despite CO poisoning. Furthermore, the one-step process is economically viable with a minimum selling price (MSP) of USD 1701 per tonne of THF, and a life cycle assessment shows a CO 2 equivalent emission of 1.29 tonnes per tonne of THF—less than 25% of that of the traditional Reppe process. This work represents a transformative advancement in sustainable THF production, with the potential to revolutionize industrial THF production.}, archive = {J_ANGEW}, author = {Wuyu Zhao and Song Song and Maofeng Ding and Wei Luo and Landong Li and Xingang Li}, doi = {10.1002/anie.202507984}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507984}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bypassing in situ CO poisoning in furfural conversion: Electron-deficient pd single-atom alloys enable one-step selective synthesis of tetrahydrofuran}, volume = {64}, year = {2025}, }
• (2025). Cascade electrocatalytic reduction of nitrate to ammonia using bimetallic covalent organic frameworks with tandem active sites. ANGEW, 64(32), e202507956. (www)

  @article{ , abstract = {Electrochemical nitrate reduction reaction (NO 3 RR) is a promising approach to simultaneously realize pollutant removal and ammonia generation. However, this process involves the transfer of eight electrons and nine protons along with multiple by-products, resulting in a significant challenge for achieving high ammonia yield and selectivity. Herein, we introduced bimetallic covalent organic frameworks catalysts with Cu and Co active sites to achieve a two-step tandem reaction, avoiding excessive nitrite accumulation and enabling efficient NO 3 RR. For the initial two-electron process, the Cu sites in the bimetallic catalyst exhibit a strong binding affinity with nitrate, promoting their conversion to nitrite. The Co sites enhance the supply and adsorption of active hydrogen and stabilize the subsequent six-electron process, thereby improving the overall catalytic efficiency. Compared to monometallic Cu and Co catalysts, the CuCo bimetallic catalyst demonstrates superior ammonia yield and Faradaic efficiency (NH 3 yield rate = 20.8 mg·h −1 ·cm −2 , FE = 92.16% in 0.3 M nitrate). Such coordinated two-step process advances the efficiency and applicability of NO 3 RR through optimizing a cascade catalytic reaction, thereby establishing an innovative path for the engineering of NO 3 RR electrocatalysts.}, archive = {J_ANGEW}, author = {Jian Zhong and Haiyan Duan and Mingquan Cai and Ying Zhu and Zhenlin Wang and Xingchi Li and Zhengliang Zhang and Wenqiang Qu and Kai Zhang and Donglin Han and Danhong Cheng and Yongjie Shen and Ming Xie and Emiliano Cortes and Dengsong Zhang}, doi = {10.1002/anie.202507956}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507956}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cascade electrocatalytic reduction of nitrate to ammonia using bimetallic covalent organic frameworks with tandem active sites}, volume = {64}, year = {2025}, }
• (2025). Direct integration of functionalized bridges by one-step superacid-catalyzed reaction to fabricate porous polymers for CO2 capture and separation. ANGEW, 64(32), e202507863. (www)

  @article{ , abstract = {A novel class of ultra-microporous functionalized porous organic polymers (POPs) was developed starting from glyoxylic acid as a cross-linker and triflic acid as a catalyst on polyaromatic monomers, generating in situ methine bridges with carboxylic acids. This one-pot synthetic method generated functionalized POPs with high connectivity per each aromatic group and a high density of aliphatic carboxylic acids decorating the pore walls. Remarkably, the functional groups were transformed into esters, Na- and Li-carboxylates by post-synthetic modification with high yields, generating polyionic porous polymers. These porous polymers displayed excellent CO 2 adsorption at 298 K and isosteric heat of adsorption with values as high as 50 kJ mol −1 for the Na-containing POP endowed with numerous ionic charges, as estimated by direct measurements with microcalorimetry coupled to CO 2 adsorption isotherms. Dynamic breakthrough experiments on self-supporting monolithic composites demonstrated high selectivity for CO 2 adsorption over N 2 up to 500 for diluted streams and 340 under relevant conditions for carbon capture from flue gases (0.15 CO 2 partial pressure).}, archive = {J_ANGEW}, author = {Jacopo Perego and Sergio Piva and Charl Xavier Bezuidenhout and Angiolina Comotti and Piero Sozzani and Silvia Bracco}, doi = {10.1002/anie.202507863}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507863}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct integration of functionalized bridges by one-step superacid-catalyzed reaction to fabricate porous polymers for CO2 capture and separation}, volume = {64}, year = {2025}, }
• (2025). Unveiling roles of nonradical electron-donation pathway in peroxymonosulfate activation for boosted interfacial radical generation. ANGEW, 64(32), e202507772. (www)

  @article{ , abstract = {In conventional studies, radicals and nonradicals were often considered independent mechanisms for organic pollutant oxidation, with their potential interaction between radicals and nonradicals largely overlooked in Fenton-like reactions. Herein, Cu-Co 3 O 4 catalysts ( x wt% Cu-Co 3 O 4 /OVs) featuring bifunctional bonding centers were fabricated, which enabled simultaneous co-capture of electron-rich contaminants and peroxymonosulfate (PMS) at their interfaces. The optimized 0.75 wt% Cu-Co 3 O 4 /OVs demonstrated exceptional efficiencies in degrading diverse micropollutants through synergistic oxidation pathways involving radicals and nonradical electron transfer process (ETP). Significantly, we found the unique dual electron migration pathways for PMS activation during synergistic oxidation process: besides the electron donation from Co centers, electron could be migrated via ETP from micropollutants to Co sites via heteroatomic Cu, serving as additional electron source for assisting PMS activation. In addition, synergistic oxidation pathways not only enhanced the generation of reactive species but also improved their utilization efficiency by shortening the migration distance of radicals. Such system exhibited remarkable long-term stability (up to 16 h) in wastewater treatment, with its environmental applicability further validated through life cycle assessment and bio-experiments. This work uncovered a previously unrecognized synergistic interaction between radical and nonradical pathways, offering new insights into the interfacial radical-mediated oxidation behavior for advanced wastewater remediation.}, archive = {J_ANGEW}, author = {Yu-Hang Li and Cai-Yi Chen and Shuai Gao and Chong-Chen Wang and Yin Li and Mingyi Liu and Hongyu Chu and Zhile Pan and Sihui Zhan and Haodong Ji}, doi = {10.1002/anie.202507772}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling roles of nonradical electron-donation pathway in peroxymonosulfate activation for boosted interfacial radical generation}, volume = {64}, year = {2025}, }
• (2025). Acidic nitrate electroreduction with ultrahigh energy efficiency. ANGEW, 64(32), e202507724. (www)

  @article{ , abstract = {Ammonia (NH 3 ) is an important feedstock for industry, an ideal energy carrier, and a perspective storage media for hydrogen. Recently, electrochemical nitrate (NO 3 −) reduction under acidic conditions has received considerable attention but it suffers from limited efficiency especially under low NO 3 − concentration. Here, we report an in situ formed positively charged polyethyleneimine-modified Cu under acidic conditions as a catalyst-electrolyte interface (CEI) for electrochemical NO 3 − reduction to NH 3 . Such CEI can effectively accumulate NO 3 − anions via static interactions and accelerate *NO hydrogenation to *NOH by weakening *NO intermediate adsorption on Cu site, thereby facilitating NO3−-to-NH 3 conversion. Such CEI delivers an increased NH 3 Faradaic efficiency (FE) of 83.5% and an impressive half-cell energy efficiency (EE) of 37.1% in 10 mM NO 3 − solution (pH = 1). The NH 3 FE and EE can further increase to 90.2% and 44.1% in 0.5 M NO 3 −, respectively. The high EE of CEI surpasses previously reported catalyst performances for NO 3 − reduction. Finally, we demonstrate the feasibility of a novel NO 3 −-furfural battery, showcasing a self-power electrocatalytic system capable of simultaneously treating NO 3 − pollutants, generating value-added NH 3 and upgrading biomass. This work offers valuable insights into the construction of a CEI to enhance the efficiency of NH 3 synthesis.}, archive = {J_ANGEW}, author = {Rong Zhang and Xintao Ma and Shaoce Zhang and Huilin Cui and Chuan Li and Yanbo Wang and Qing Li and Chao Peng and Ying Guo and Chunyi Zhi}, doi = {10.1002/anie.202507724}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507724}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Acidic nitrate electroreduction with ultrahigh energy efficiency}, volume = {64}, year = {2025}, }
• (2025). SH2 decarboxylative monofluoromethylation of aliphatic carboxylic acids enabled by Nickel/Photoredox dual catalysis. ANGEW, 64(32), e202507632. (www)

  @article{ , abstract = {Catalytic construction of alkyl fluorides through C─C bond-forming transformations represents a formidable challenge in modern organofluorine chemistry. In this work, we present a decarboxylative monofluoromethylation protocol enabled by synergistic nickel/photoredox dual catalysis for aliphatic carboxylic acid derivatives. A structurally diverse array of tertiary, secondary, and primary N -hydroxyphthalimide (NHP) esters underwent efficient conversion to their corresponding fluoromethylated products with excellent functional group tolerance (68 examples, up to 91% yield). The methodology's versatility was highlighted through late-stage monofluoromethylation of pharmaceutically relevant molecules. Mechanistic investigations reveal the involvement of a radical rebound pathway mediated by nickel (III) intermediate, with the homolytic substitution (S H 2) process at sterically congested center representing a critical mechanistic distinction from conventional cross-coupling paradigms.}, archive = {J_ANGEW}, author = {Ting-Yu Fang and Meng-Ye Jiang and Meng-Meng Zheng and Jun-An Ma and Fa-Guang Zhang}, doi = {10.1002/anie.202507632}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507632}, shortjournal = {Angew. Chem. Int. Edit.}, title = {SH2 decarboxylative monofluoromethylation of aliphatic carboxylic acids enabled by Nickel/Photoredox dual catalysis}, volume = {64}, year = {2025}, }
• (2025). Reticular synthesis of 3D metal cluster-based COFs with record high-connectivity for efficient photocatalytic H2O2 synthesis. ANGEW, 64(32), e202507624. (www)

  @article{ , abstract = {The assembly of metal clusters with organic building units by covalent bonds to form metal cluster-based covalent-organic frameworks (MCCOFs) material is a novel strategy in reticular synthesis. However, only 2, 3, and 6 connectivity of MCCOFs have been achieved in reported structures. Developing a higher connectivity remains a great challenge in the MCCOFs due to the difficulties in introducing multiple connecting nodes to the metal cluster. In this work, two 3D [8 + 2]-connected MCCOFs were synthesized by condensing an 8-connectivity aluminum cluster-based building block (termed Al 8 -8c) with linear dialdehyde linkers. Furthermore, these AlCCOFs showed efficient photocatalytic O 2 -to-H 2 O 2 conversion due to the suitable energy band structure, efficient photoelectron conversion capability and the AlCCOF-1 showed H 2 O 2 photosynthetic efficiency of 16794.69 µmol g −1 h −1 using water and benzyl alcohol reaction system. The in situ EPR, in situ FTIR, and DFT calculations were then performed to study the structure-function relationships on the two AlCCOFs for H 2 O 2 photosynthesis. This work is the first report of high-connectivity MCCOFs bearing 8-connected cluster units, showing the great potential of using metal clusters to construct complicate reticular frameworks by covalent linkage.}, archive = {J_ANGEW}, author = {Mi Zhang and Pei Huang and Run-Han Li and Ying-Ying Huang and Ming-Hao Qin and Yan-Yu Peng and Si-Miao Wang and Yong Yan and Meng Lu and Ya-Qian Lan}, doi = {10.1002/anie.202507624}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507624}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reticular synthesis of 3D metal cluster-based COFs with record high-connectivity for efficient photocatalytic H2O2 synthesis}, volume = {64}, year = {2025}, }
• (2025). Peptide-carbazolyl cyanobenzene conjugates: Enabling biomolecule functionalization via photoredox and energy transfer catalysis. ANGEW, 64(32), e202507602. (www)

  @article{ , abstract = {Since their discovery in 2012, carbazolyl (iso)phthalonitrile (Cz(I)PN) derivatives have found significant applications as photocatalysts (PCs) in organic chemistry. Herein, we introduce two efficient methods for incorporating carbazolyl cyanobenzenes into various peptide sequences. The first method involves a photomediated decarboxylative functionalization of the C-terminus of peptides, leading to the formation of various carbazolyl benzonitrile (CzBN) derivatives. The second method exploits a cysteine-selective S N Ar reaction on a fluorinated arene precursor, resulting in novel peptide-3CzIPN (triscarbazolyl-isophthalonitrile) conjugates. Both types of conjugates maintain delayed fluorescence properties, exhibit similar or wider redox potential, and possess higher excited state energy when compared to currently used cyanoarenes. We demonstrated the photocatalytic activity of these conjugates first through a photo-mediated peptide C-terminal decarboxylative alkynylation. Then, water-soluble peptide conjugates were used to catalyze a thiol-ene reaction on cysteine in aqueous media. Finally, we achieved protein labeling via aryl azide excitation both in vitro and at the cellular level using peptide-CzIPN conjugates. By incorporating a peptide ligand of the protein integrin α v β 3 , proximity-driven labeling next to this target was realized by aryl azide excitation in living cells, showing an excellent overlap with antibody-based imaging. These findings reveal the potential of cyanoarene-peptide conjugates for proximity-driven photochemistry in a complex biological context.}, archive = {J_ANGEW}, author = {Xing-Yu Liu and Wei Cai and Anne-Sophie Chauvin and Beat Fierz and Jerome Waser}, doi = {10.1002/anie.202507602}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Peptide-carbazolyl cyanobenzene conjugates: Enabling biomolecule functionalization via photoredox and energy transfer catalysis}, volume = {64}, year = {2025}, }
• (2025). Ionic polarization-driven defect engineering in Na4Fe3(PO4)2(P2O7) cathode: Fast charging and ultra-long cycle life of sodium-ion batteries. ANGEW, 64(32), e202507573. (www)

  @article{ , abstract = {The Na 4 Fe 3 (PO 4 ) 2 (P 2 O 7 ) (NFPP) cathode material faces the challenge of coordinating the improvement of high-rate performance and long-cycle stability for sodium-ion batteries (SIBs). This study proposes an ionic polarization-driven defect engineering strategy, which regulates the electronic structure and Na + transmission dynamics of NFPP through Bi 3+ doping. Experimental results and theoretical calculations show that Bi 3+ with (18 + 2) electron configuration significantly enhances the crystal structure stability of NFPP by strengthening the covalency of Bi─O bonds. Meanwhile, the heterovalent Bi 3+ doping optimizes the bandgap of the material (from 3.29 to 0.16 eV) and promotes Na + diffusion, while introducing lattice defects to provide additional sodium storage sites. The optimized 0.02Bi-NFPP cathode exhibits excellent electrochemical performance as the half-cell only takes 31.6 min to charge to 80% at a rate of 1 C, and the capacity decay is only 0.000495 mA h g −1 per cycle (86.9% capacity retention) over 20,000 cycles at 20 C. The full battery based on hard carbon anode maintains 95.5% capacity retention after 200 cycles at 1 C. This study reveals the synergistic mechanism between ion polarization effect and lattice defects, and provides a new strategy for designing SIBs cathode materials with both fast charging/discharging capabilities and ultra-long life.}, archive = {J_ANGEW}, author = {Yu-Jie Wang and Zhen-Yi Gu and Dong-Sheng Bai and Ze-Lin Hao and Han-Wei Huang and Yang Yan and Cheng-Jie Li and An-Min Liu and Xing-Long Wu}, doi = {10.1002/anie.202507573}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507573}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ionic polarization-driven defect engineering in Na4Fe3(PO4)2(P2O7) cathode: Fast charging and ultra-long cycle life of sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Contrasting atomically dispersed metal catalysts supported on CeOx nanoislands with various ligand environments including chloride. ANGEW, 64(32), e202507545. (www)

  @article{ , abstract = {Metals that are dispersed atomically on supports offer new and potentially valuable catalytic properties associated with their high atom efficiencies and opportunities for tuning their electronic properties by choice of the support and other ligands bonded to them. Herein, we report the synthesis of atomically dispersed Pt, Rh, and Ir anchored on CeO x nanoislands on a high-area SiO 2 support. Synthesis from chloride-containing metal salts gave metal complexes chemisorbed on the supported nanoislands, with Pt being prototypical and having a structure approximated as Pt 1 Cl 2 O 4 , as shown by X-ray absorption spectroscopy and calculations at the level of density functional theory (DFT). Calcination converted the adsorbed species into a structure represented as Pt 1 O 6 , embedded in the CeO x lattice. The Pt 1 Cl 2 O 4 was observed to have a higher catalytic activity for CO oxidation than the chloride-free, embedded Pt 1 O 6 species, and DFT results indicate the role of chloride in enhancing the catalytic activity of the isolated Pt, in contrast to its role as an inhibitor when Pt is present as nanoparticles. This work emphasizes the importance of the first coordination shell in controlling the catalytic properties of atomically dispersed noble metals.}, archive = {J_ANGEW}, author = {Nan Zhang and Yizhen Chen and Xu Li and Chih-Wen Pao and Jiankang Zhao and Bruce C. Gates and Jie Zeng}, doi = {10.1002/anie.202507545}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507545}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Contrasting atomically dispersed metal catalysts supported on CeOx nanoislands with various ligand environments including chloride}, volume = {64}, year = {2025}, }
• (2025). Chain–Chain synergistic hydrogel electrolytes regulate zinc ions desolvation for stabilized anodes and high operating voltage in flexible zinc ions hybrid capacitors. ANGEW, 64(32), e202507403. (www)

  @article{ , abstract = {To maximize the energy density output, the complementary charge storage mechanism of aqueous zinc ion hybrid capacitors (ZIHCs) is superior and advanced, but continuous water-induced side reactions and uncontrolled dendrite growth of zinc anodes remain challenging. Additionally, the optimization of the hydrogel electrolyte/electrode interface is necessary for the stability and kinetic reversibility of the flexible zinc-based energy storage device. Herein, the P(AM-SBMA) (copolymer of acrylamide AM and zwitterionic compound SBMA)/gelatin hydrogel electrolyte (PSG) with a special semi-interpenetrating network is designed based on the chain–chain synergistic regulation mechanism to regulate the desolvation of zinc ions and optimize the operating voltage of flexible ZIHCs and stabilize surface chemistry of zinc anode. The obtained PSG-5 hydrogel electrolyte widens the electrochemical stability windows (ESW) of the flexible ZIHC to 2.45 V and achieves high Zn 2+ transference number of 0.87 and highly reversible plating/stripping of the zinc anode. Furthermore, the corresponding flexible ZIHC exhibits a high operating voltage of 2.2 V and provides a favorable energy density of 117 Wh kg −1 at a power density of 293 W kg −1 . This work provides useful insights for the development of efficient, flexible ZIHCs by preparing hydrogel electrolytes capable of stabilizing zinc anodes and widening ESW.}, archive = {J_ANGEW}, author = {Hang Zhang and Li Wan and Ziran You and Jianrong Liang and Da Lei and Yongyan Cui}, doi = {10.1002/anie.202507403}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507403}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chain–Chain synergistic hydrogel electrolytes regulate zinc ions desolvation for stabilized anodes and high operating voltage in flexible zinc ions hybrid capacitors}, volume = {64}, year = {2025}, }
• (2025). Catalytic α-site-selective hydrogen-deuterium exchange of benzylic alcohols by palladium single-atom catalyst. ANGEW, 64(32), e202507338. (www)

  @article{ , abstract = {Catalytic hydrogen-deuterium exchange (HDE) has emerged as a valuable tool for achieving site-selective deuteration and the precision labeling of bioactive molecules. Incorporation of deuterium at metabolically labile positions, enabled by such methods, can potentially improve drug efficacy through the kinetic isotope effect. However, achieving precise, site-selective incorporation of deuterium at specific molecular positions remains challenging. Herein, we report a highly efficient α-site-selective HDE of benzylic alcohols via a palladium single-atom catalyst (Pd SAC). By using the Pd SAC, exceptional activity and selectivity in HDE reactions were achieved, delivering up to 95% deuterium incorporation (D-inc.) at the α-position while effectively suppressing undesired pathways (e.g., α,β-multisite deuteration). Mechanistic investigations reveal that the Pd SAC promotes site-selective HDE through two distinct surface pathways: (i) a previously unreported direct C─H bond activation and (ii) a modified borrowing hydrogen process in which high-pressure hydrogen inhibits the keto enol tautomerization, thereby largely circumvents α,β-multisite deuteration. The catalyst exhibits robust stability, reusability, and broad substrate compatibility, underscoring its potential for practical applications. This work marks a significant advance in heterogeneous single-atom catalytic methodologies for site-selective deuteration, offering a complementary solution to longstanding challenges in catalytic organic synthesis.}, archive = {J_ANGEW}, author = {Shu-Xian Li and Xiang-Ting Min and Juan Su and Boyu Yu and Wenhao Cui and Jing-Jing Tang and Botao Qiao}, doi = {10.1002/anie.202507338}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507338}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic α-site-selective hydrogen-deuterium exchange of benzylic alcohols by palladium single-atom catalyst}, volume = {64}, year = {2025}, }
• (2025). Anion vacancies triggered spin polarization enables efficient piezocatalysis for water cleanup. ANGEW, 64(32), e202507265. (www)

  @article{ , abstract = {The conversion of aromatic organic pollutants into value-added chemical feedstocks is still suffering from sluggish carbon reduction kinetics with spin-forbidden transitions. Here, we report an anion vacancy-triggered spin polarization strategy to efficiently convert phenol into carbon monoxide (CO) with fast kinetics. The creating Se vacancies (V se ) stimulate the spin polarization of both Fe and Mo in Fe single atom modified MoSe 2 (Fe/MoSe 2 ), in which spin polarization can enhance the quantity of spin electrons and facilitate the transport of electrons that share the same spin direction with greater efficiency in charge separation. Batch experiments and theoretical calculations reveal that the unpaired spin electrons of Fe and Mo atoms not only accelerate the formation and immobilization of key intermediate *COOH, but also provide spin electrons for *COOH further cleavage with a lower reaction energy barrier. Moreover, profiting from the crucial bridging role of peroxydisulfate (PDS), phenol can be first oxidized to carbonate/CO 2 through PDS activation and then provide a sufficient carbon source for CO formation with favorable reaction kinetics. Impressively, the Fe/MoSe 2 piezocatalysis coupled with PDS exhibits 298.28 µmol·g −1 CO production rate for phenol degradation with over 60 h durability.}, archive = {J_ANGEW}, author = {Qiang Zhong and Yue Sun and Shao-Gui Yang and Chen-Min Xu and Zhao-Qing Liu and Kan Zhang and Shi-Cheng Yan and Huan He}, doi = {10.1002/anie.202507265}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507265}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion vacancies triggered spin polarization enables efficient piezocatalysis for water cleanup}, volume = {64}, year = {2025}, }
• (2025). Visible-light-controlled lysine-selective crosslinking decodes protein complexes and dynamic interactomes in live cells. ANGEW, 64(32), e202507254. (www)

  @article{ , abstract = {Crosslinking strategies have emerged as an attractive technology for deciphering protein complexes and protein–protein interactions (PPIs). However, commonly used crosslinking strategies present significant challenges for the precise analysis of protein complexes and dynamic PPIs in native biological environments. Here, we report the development of the first visible-light-inducible lysine-specific homobifunctional photo-crosslinkers and introduce V isible-light-controlled L ysine-selective crosslinking (VL-XL) strategy for in-depth analysis of protein complexes and profiling dynamic interactomes in live cells. By synergistically integrating the advantages of temporal control, high biocompatibility, and lysine selectivity, the VL-XL strategy not only provides an effective solution for protein complexes studies—achieving residue-specific crosslinked peptides, delivering high-confidence data and streamlined mass spectrometry (MS) data analysis—but also reveals dynamic interactomes in various scenarios. The VL-XL strategy successfully profiles the time-resolved, epidermal growth factor (EGF)-stimulated epidermal growth factor receptor (EGFR) interactome, providing valuable insights into regulatory mechanisms of EGFR signaling. More importantly, the VL-XL strategy effectively unveils molecular glue degrader-induced E3 ligase interactome, leading to discovery of neo-substrates such as Sestrin-2 (SESN2) and opening an innovative avenue for identifying novel targets for degradation. Overall, the VL-XL strategy provides a robust chemical tool, inspiring innovative solutions to address unresolved questions in multiple fields.}, archive = {J_ANGEW}, author = {Yali Xu and Hao Hu and Yu Ran and Wensi Zhao and An-Di Guo and Hui-Jun Nie and Linhui Zhai and Guang-Liang Yin and Jintao Cheng and Shengna Tao and Bing Yang and Minjia Tan and Xiao-Hua Chen}, doi = {10.1002/anie.202507254}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507254}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-light-controlled lysine-selective crosslinking decodes protein complexes and dynamic interactomes in live cells}, volume = {64}, year = {2025}, }
• (2025). Synergistic dual-interface engineering in perovskite solar cells via chloramine hydrochloride molecular bridges. ANGEW, 64(32), e202507182. (www)

  @article{ , abstract = {High-performance perovskite solar cells (PSCs) require synergistic passivation strategies to address defects at the electron transport layer (ETL)/perovskite interface, impacting both efficiency and long-term stability. This study introduces chloramine hydrochlorides (CAHs) – 2-Chloroethylamine Hydrochloride (CEA), Bis(2-chloroethyl)amine Hydrochloride (BCEA), and Tris(2-Chloroethyl)Amine Hydrochloride (TCEA) – as bifunctional molecular bridges to simultaneously passivate defects at both ETL (SnO 2 ) and perovskite interfaces while controlling crystallization. Density functional theory calculations showed that TCEA forms strong Sn─Cl bonds, enhancing Sn⁴ + coordination. In situ characterization revealed that TCEA accelerated perovskite formation, suppressed PbI 2 , and promoted larger grains, thus minimizing grain boundary defects. This leads to an improved electron extraction efficiency, prolonged hot-carrier cooling, and a champion power conversion efficiency (PCE) of 25.25% (compared to 23.64% for controls), with negligible hysteresis and 90% PCE retention after 1000 h under ambient conditions. This study establishes a universal molecular design strategy for dual-interface engineering in high-efficiency and stable PSCs.}, archive = {J_ANGEW}, author = {Feiyi Zhou and Xu Zhang and Runze Dai and Qingyue Guo and Yi Dong and Fanxiang Meng and Jun Wan and Zeyu Wang and Huajie Lyu and Chenghang Zheng and Qingquan He and Rui Wang and Peng Liu and Jun Pan and Xiang Gao}, doi = {10.1002/anie.202507182}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507182}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic dual-interface engineering in perovskite solar cells via chloramine hydrochloride molecular bridges}, volume = {64}, year = {2025}, }
• (2025). Mechanism-driven bioactive indazole frameworks: Photoinitiated Demethylation–Aromatization synthesis and biosensing applications. ANGEW, 64(32), e202507163. (www)

  @article{ , abstract = {Indazole frameworks are pivotal in medicinal chemistry and fluorescent conjugate design. Herein, we reported a photochemical strategy enabling efficient N -demethylation and aromatic cyclization of N -methyl amines via UV-induced nitroso intermediates, offering an environmentally benign route to structurally diverse 2 H -indazole scaffolds. Diverging from conventional methods, this protocol demonstrates exceptional substrate compatibility with various alkyl/aryl amines, facilitating streamlined assembly of functionalized 2 H -indazole modules. The methodology has been successfully applied to synthesize modified drugs and tumor-specific fluorescent probes targeting G-quadruplexes. Preliminary evaluations of physiological toxicity and cellular fluorescence imaging highlight their biomedical potential, establishing these strategies as potential tools for pharmacological development and bioimaging research.}, archive = {J_ANGEW}, author = {Yi-Feng Ou and Songhua Chen and Qian Lei and Yang Shen and Niu Tang and Yongbo Zhou and Shuang-Feng Yin and Nobuaki Kambe and Lin Yuan and Renhua Qiu}, doi = {10.1002/anie.202507163}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507163}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanism-driven bioactive indazole frameworks: Photoinitiated Demethylation–Aromatization synthesis and biosensing applications}, volume = {64}, year = {2025}, }
• (2025). Mechanism of first proton-coupled electron transfer of water oxidation at the BiVO4–Water interface. ANGEW, 64(32), e202507071. (www)

  @article{ , abstract = {The oxygen evolution reaction (OER) at the –water interface is considered to be the bottleneck of the overall water splitting at this aqueous interface. To provide insight into the mechanism of this reaction, the focus is set on the first proton-coupled electron transfer (PCET). The free-energy surface of this first step is obtained by combining on-the-fly probability-enhanced sampling and machine learning potentials at the hybrid functional level of accuracy. Our study reveals that proton transfer precedes electron transfer and determines the reaction barrier, consistent with kinetic-isotope-effect experiments. The calculated reaction barrier amounts to eV. The proton moves from the adsorbed water molecule to a surface O atom through a direct transfer mechanism. The hole hopping to the resulting hydroxide occurs via the mediation of a surface Bi atom. The presented framework can be generally applied to other PCET steps and other oxides, thus opening the door to a comprehensive investigation of the OER mechanism at oxide–water interfaces.}, archive = {J_ANGEW}, author = {Yong-Bin Zhuang and Alfredo Pasquarello}, doi = {10.1002/anie.202507071}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507071}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanism of first proton-coupled electron transfer of water oxidation at the BiVO4–Water interface}, volume = {64}, year = {2025}, }
• (2025). Synthesis of versatile DNA-conjugated aldehydes by controlled oxidation of amines. ANGEW, 64(32), e202507064. (www)

  @article{ , abstract = {Aldehyde-functionalized oligonucleotides have found diverse applications in chemical biology and material science. However, due to the electrophilic nature of aldehydes, incorporating aldehyde functionalities directly into DNA is challenging, particularly for highly reactive alkyl aldehydes. Inspired by natural oxidases, we herein developed a controlled oxidation strategy to generate aldehyde-functionalized DNAs from synthetically accessible DNA-conjugated amines in situ. A broad range of DNA-conjugated alkyl and aryl aldehydes were efficiently produced from the corresponding amines using O 2 /laccase/TEMPO, with feasible micromole-scale preparation. Moreover, combining oxidative cleavage of DNA-conjugated secondary and tertiary amines with reductive amination enabled switchable amine–aldehyde transformation and reversible solid-phase bioconjugation of DNA probes. Furthermore, the reactivity “umpolung” from nucleophilic amines to electrophilic aldehydes highlights its potential for synthesizing chemically diverse DNA-encoded libraries (DELs). In summary, the presented controlled oxidation strategy expands the current toolbox to introduce aldehyde functionalities into DNAs within a chemical biological context.}, archive = {J_ANGEW}, author = {Guixian Zhao and Mengping Zhu and Pengyang He and Qigui Nie and Yangfeng Li and Gong Zhang and Yizhou Li}, doi = {10.1002/anie.202507064}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507064}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of versatile DNA-conjugated aldehydes by controlled oxidation of amines}, volume = {64}, year = {2025}, }
• (2025). Cooperative ammonia formation catalyzed by molybdenum and samarium complexes. ANGEW, 64(32), e202507061. (www)

  @article{ , abstract = {A series of novel samarium complexes bearing cyclopentadienyl–amide chelate ligands were synthesized and characterized by X-ray analysis. The complexes function as effective proton-coupled electron transfer (PCET) catalysts, facilitating molybdenum-catalyzed ammonia formation from dinitrogen under ambient conditions. In this reaction system, the Sm complexes could be recycled over 300 times, and they increased the ammonia formation rate by sevenfold compared to that obtained for reactions occurring in the absence of such complexes. Experimental results and density functional theory calculations indicate that the Sm complexes undergo protonation and reduction to form Sm(II) complexes, which then accelerate proton and electron transfer to the Mo complexes via PCET processes from the terminal proton source and reductant. This paper presents the first successful example of Sm complexes that can function as efficient catalysts for 300 cycles, promoting proton and electron transfer in Mo-catalyzed ammonia formation.}, archive = {J_ANGEW}, author = {Taichi Mitsumoto and Taiji Nakamura and Hiromasa Tanaka and Kazunari Yoshizawa and Yoshiaki Nishibayashi}, doi = {10.1002/anie.202507061}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507061}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative ammonia formation catalyzed by molybdenum and samarium complexes}, volume = {64}, year = {2025}, }
• (2025). Non-innocent ligands as mediators for visible-light-initiated Element–Carbon bond homolysis in main group chemistry. ANGEW, 64(32), e202507060. (www)

  @article{ , abstract = {Photoinitiated homolysis of element–carbon bonds is an important method for the generation of carbon-centered radicals in catalysis and organometallic or polymer chemistry. In this respect, the use of earth-abundant main group elements such as aluminum or silicon is attractive. Generally, subvalent species derived from these typically redox-inactive elements are unstable and within their high-valent configuration +III (Al) or +IV (Si) comparatively strong E─C bonds are formed. Therefore, E─C homolysis usually requires shortwave UV irradiation, which hampers their use as radical sources. Some reports in the literature show that visible-light-induced E─C homolysis is possible when a redox non-innocent ligand (NIL) is coordinated to the organometallic fragment. In a simplified view, the NILs provide chromophoric moieties, which can absorb energy in form of light and subsequently convert it to break the element–carbon bonds. The resulting main group element radicals are in turn stabilized by delocalization of the unpaired electron, effectively lowering the dissociation energy of the E─C bond. In this article, the effects of NILs as mediators for visible-light-induced E─C bond homolysis in main group chemistry are discussed on the basis of selected literature reports, and future opportunities and challenges are highlighted.}, archive = {J_ANGEW}, author = {Jonas O. Wenzel and Johannes Werner and Frank Breher}, doi = {10.1002/anie.202507060}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202507060}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-innocent ligands as mediators for visible-light-initiated Element–Carbon bond homolysis in main group chemistry}, volume = {64}, year = {2025}, }
• (2025). Elucidating the correlation between the redox potential, spin state, and crystal structure in a series of ferrous complexes with redox-active ligands. ANGEW, 64(32), e202506965. (www)

  @article{ , abstract = {Accurately predicting the spin crossover (SCO) temperature ( T 1/2 ) in spin crossover compounds remains a significant challenge due to their extreme sensitivity to minor variations in ligand and crystal structure. In this study, we uncover a critical link between the redox potential of ligands and SCO behavior within Hofmann-type clathrates {Fe(R-pbpy⁺)₂[μ₂-M(CN)₄]₂} (R = electron-donating or electron-withdrawing groups, M = Pd or Pt). Through precise tuning of the ligands' electronic properties, we establish a correlation between redox potential, space group, and SCO temperature, explained by an adaptation of Marcus theory of electron transfer. These findings not only provide a deeper understanding of the factors governing SCO behavior but also present a promising strategy for the rational design of SCO materials with tailored properties.}, archive = {J_ANGEW}, author = {Livia Getzner and Yasmine Remili and Zakaria Ziani and Laure Vendier and William Nicolazzi and Aurelian Rotaru and Haizhu Yu and Gábor Molnár and Saioa Cobo and Azzedine Bousseksou}, doi = {10.1002/anie.202506965}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506965}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elucidating the correlation between the redox potential, spin state, and crystal structure in a series of ferrous complexes with redox-active ligands}, volume = {64}, year = {2025}, }
• (2025). Probing the heteroepitaxial seeded growth and self-sorting processes of segmented co-micelles with chemically distinct crystalline cores. ANGEW, 64(32), e202506872. (www)

  @article{ , abstract = {The ability to produce uniform micellar nanoparticles with controlled dimension and spatially controlled functionality is a key challenge in nanoscience. Living crystallization-driven self-assembly (CDSA) of block copolymers (BCP) has emerged as an effective approach to generate uniform size-tunable core-shell micellar nanoparticles; however, most core-shell micelles generated via CDSA consist of a continuous crystalline core from BCPs with the same core-forming block. Herein, we perform insightful studies of heteroepitaxial CDSA process from chemical distinct core-forming poly(ferrocenyldimethylgermane) (PFDMG) and poly(ferrocenyldimethylsilane) (PFDMS) based BCPs to produce segmented block comicelles. The heteroepitaxial growth process produced micelles with kinetically trapped crystalline cores that are thermodynamically less stable than the materials formed via spontaneous nucleation. This was rationalized by determining the previously unknown core lattice of PFDMG micelles, self-assembly experiments, and theoretical lattice energy calculations, providing an insight into the energetic penalty associated with heteroepitaxial growth. These methods for determining the theoretical core lattice energies in these BCP systems could provide a way to screen BCP candidates that can undergo heteroepitaxial growth. Furthermore, by using our newfound understanding of these micelle systems, we achieved the formation of micelles with crystalline cores that undergo self-sorting, driven by self-seeding from fragmented triblock comicellar structures.}, archive = {J_ANGEW}, author = {Samuel Pearce and Harvey K. MacKenzie and Huda Shaikh and Zhonghuan Liu and Robert Harniman and Jean Charles Eloi and Sean Davis and Robert M. Richardson and Etienne A. LaPierre and Ian Manners and Yifan Zhang}, doi = {10.1002/anie.202506872}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing the heteroepitaxial seeded growth and self-sorting processes of segmented co-micelles with chemically distinct crystalline cores}, volume = {64}, year = {2025}, }
• (2025). Identification of isomerically diverse ginsenosides using engineered aerolysin nanopore via non-translocation blockade sensing. ANGEW, 64(32), e202506741. (www)

  @article{ , abstract = {Typical nanopore sensing depends on slowed translocation through the pore to acquire effective blockade signals. However, this paradigm often suffers from low signal precision and poor resolution, making it challenging to resolve pools of analytes with diverse, similar structures. Here, we present a non-translocation blockade sensing based on an engineered aerolysin S278K that enables the identification of isomerically diverse ginsenosides—a class of glycoconjugates whose structural characterization has been a persistent challenge in glycoscience. By introducing the S278K mutation, the aerolysin acquires a highly positively charged interior and generates intense electro-osmotic flow and enhanced steric/enthalpic barriers, effectively trapping ginsenoside molecules in the K278-R220 region and preventing their further translocation. This distinct blockade sensing mode significantly improves the detection capability of aerolysin by prolonging residence time (e.g., 43-fold longer), enabling detailed molecular characterization. As a result, we demonstrate the unambiguous identification of 30 ginsenosides differing in glycosyl composition, isomerism, modification, and aglycone, as well as the quantitative analysis of complex ginsenosides in real samples by integrating deep learning. This work underscores the promise of non-translocation nanopore sensing for deciphering structurally complex and diverse small molecule analytes.}, archive = {J_ANGEW}, author = {Jing Wang and Minmin Li and Chen Zhang and Xinjia Zhao and Yuting Xiong and Yuchen Cao and Dongdong Wang and Xiaonong Li and Xinmiao Liang and Guangyan Qing}, doi = {10.1002/anie.202506741}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506741}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identification of isomerically diverse ginsenosides using engineered aerolysin nanopore via non-translocation blockade sensing}, volume = {64}, year = {2025}, }
• (2025). Synergistic stabilization of pt single atoms by cl and ru for industrial-scale current density hydrogen production. ANGEW, 64(32), e202506619. (www)

  @article{ , abstract = {Pt single-atom (SA) catalysts are considered ideal cathodic materials for PEM water electrolysis (PEMWE) due to their excellent atom utilization and tunable local coordination environment, yet their durability for practical applications remains an unresolved challenge. Herein we report the Pt SAs, synergistically stabilized by Cl-ligand and Ru nanoparticles, exhibit both high activity and durability for hydrogen evolution reaction (HER). A key finding is that the dynamically evolved Pt–Cl–Pt coordination structure protects Pt SAs against aggregation. Theoretical analysis reveals the unique electronic structure of Pt SAs is finely tuned through the synergistic role of Ru and Cl, resulting in a notable stabilization of Pt SAs. PEMWE with such a catalyst at an ultra-low Pt loading delivers a cell voltage of only 1.66 V at a current density of 1.0 A cm −2 , while maintaining the outstanding electrocatalytic and structural stability of the Pt–Cl–Pt coordination over 1000 h, thus providing an application potential of SA catalysts.}, archive = {J_ANGEW}, author = {Qiansen Wang and Wenhui Ling and Yang Lu and Hao Zhao and Qingqing Cheng and Yifan Huang and Lianhai Zu and Bo Yang and Hui Yang}, doi = {10.1002/anie.202506619}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506619}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic stabilization of pt single atoms by cl and ru for industrial-scale current density hydrogen production}, volume = {64}, year = {2025}, }
• (2025). Engineering a meltable MOF to tune liquid transition and promote coenzyme regeneration. ANGEW, 64(32), e202506570. (www)

  @article{ , abstract = {Modulating the liquid phase of metal–organic frameworks (MOFs) presents new opportunities for functionalizing glassy MOFs, expanding the fundamental science and practical application for this emerging family of materials. Herein, we report the fabrication of a bimetallic glassy MOF via a liquid–liquid transition process. This is achieved by introducing a robust Schiff base–cobalt functional group into Zn-ZIF-62, which attracts negatively charged imidazolate ligands, facilitating low-temperature melting. This ultimately leads to the formation of a bimetallic glassy MOF (Co/Zn-a g ZIF-62-ipy) upon melt-quenching. The material features an exceptionally high glass-forming capability, uniformly distributed bimetallic ions, and a markedly enhanced visible light photogeneration efficiency of enzymatically active nicotinamide adenine dinucleotide (NADH) when compared with Co-doped ZIF-62 glass. These findings offer novel insights into modulating the liquid phase of an MOF to develop functional glassy MOF photocatalysts for coenzyme NADH regeneration and other advanced applications.}, archive = {J_ANGEW}, author = {Wengang Huang and Wen-Long Xue and Peng Chen and Zhiliang Wang and Rijia Lin and Shuke Zhao and Shuwen Yu and Yuelei Chen and Xiangyi Zha and Dominique Appadoo and Tian Tian and Vicki Chen and Sebastian Henke and Anthony K. Cheetham and Lianzhou Wang and Jingwei Hou}, doi = {10.1002/anie.202506570}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506570}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering a meltable MOF to tune liquid transition and promote coenzyme regeneration}, volume = {64}, year = {2025}, }
• (2025). Robust ionic gel elastomers derived from molecularly entangled nodes. ANGEW, 64(32), e202506559. (www)

  @article{ , abstract = {In various types of intelligent devices, such as bionic robots, flexible polymeric elastomeric materials are essential for their operation, alongside the rigid skeleton. Conventional polymeric elastomeric materials, however, encounter a compromise between intelligence and mechanical robustness. Here, we construct ionic gel-based elastomers that harmoniously merge high intelligence with superior mechanical attributes by employing molecularly entangled nodes that facilitate polymer chain entanglement. The entangled nodes’ dynamic interplay enables stress-induced dissociation, promoting polymer chain slippage that effectively dissipates energy and disperses stress. Consequently, these ionic gel-based elastomers exhibit a tensile strength of 33.5 ± 0.5 MPa and a strain capacity of 4000 ± 280%, maintaining stable performance over 7000 cycles, while also possessing the ability to detect minor material defects, thereby advancing the versatility and reliability of intelligent devices.}, archive = {J_ANGEW}, author = {Honggang Mei and Chen Liu and Nan Jiang and Jiao Wang and Zejian He and Xue Yang and Yanfang Wang and Dong Zhao and Yuping Wang and Sheng Zhang and Guangfeng Li and Feihe Huang}, doi = {10.1002/anie.202506559}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506559}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust ionic gel elastomers derived from molecularly entangled nodes}, volume = {64}, year = {2025}, }
• (2025). Co-sustained release strategy of nonflammable gel polymer electrolytes enables long-life sodium metal batteries. ANGEW, 64(32), e202506349. (www)

  @article{ , abstract = {Sodium metal batteries (SMBs) with gel polymer electrolytes (GPEs) are considered promising candidates for high energy-density batteries due to their high theoretical capacity and cost effectiveness. However, the intrinsic flammability of GPE poses challenges for their widespread application. Inspired by the concept of the capsules, a triethyl phosphate (TEP)-based GPE with co-sustained release effect has been designed. This structure features an insoluble ethoxylated trimethylopropane triacrylate (ETPTA) polymer matrix combined with carbonate co-solvents, effectively reducing the corrosion of TEP on sodium metal anodes while maintaining a continuous flame-retardant effect. In this distinctive structure, the abundant carbonyl group on ETPTA promotes the uniform migration of sodium ions, whereas the carbonate co-solvent facilitates the formation of a NaF-rich solid electrolyte interphase (SEI) layer, effectively suppressing the growth of sodium dendrite. Low content of TEP guide the preferential orientation of the (100) crystal plane of sodium anode, enhancing the long-term cycling stability. Na/GPE/Na cells can achieve stable cycling for over 1600 h, and the NVP/GPE/Na full cells exhibit 86.6% capacity retention after 4000 cycles. Moreover, the engineered GPE enables the operation of a 4.5 V high-voltage cathode for 500 cycles. This strategy paves a new way for designing high-safety GPE tailored for high-performance SMBs.}, archive = {J_ANGEW}, author = {Huiting Yang and Yanjin Chen and Wenyue Tian and Shaohui Yuan and Pei Liu and Qinglun Wang and Ting Jin and Lifang Jiao}, doi = {10.1002/anie.202506349}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506349}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Co-sustained release strategy of nonflammable gel polymer electrolytes enables long-life sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Harnessing bifunctional N-benzoyloxyamides for photoredox amidative dual functionalizations of alkenes. ANGEW, 64(32), e202506290. (www)

  @article{ , abstract = {Here, we present a photocatalytic strategy for the intermolecular dual functionalizations of alkenes using N─O bifunctional reagents in an atom-economical fashion. By leveraging N -benzoyloxyamides as bifunctional precursors for generating both amidyl radical and internal O-nucleophiles, this approach achieves chemoselective olefin amidation with simultaneous incorporation of additional functional groups. The current method readily accesses a range of doubly functionalized amino products through 1,2-amidooxygenation, amidoazidation, and formal anti -Markovnikov hydroamidation. Mechanistic studies revealed that the selective interplay of radical and ionic pathways is operative to enable a unified platform for this olefin dual functionalization.}, archive = {J_ANGEW}, author = {Harin Ryoo and Hyeyun Keum and Dongwook Kim and Sukbok Chang}, doi = {10.1002/anie.202506290}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506290}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing bifunctional N-benzoyloxyamides for photoredox amidative dual functionalizations of alkenes}, volume = {64}, year = {2025}, }
• (2025). Epitaxial electrodeposition of lithium metal in cubic wulff structures. ANGEW, 64(32), e202506119. (www)

  @article{ , abstract = {Electrodeposition of lithium (Li) metal is crucial for highenergydensity rechargeable Li batteries. The electrodeposition morphology governs the reversibility of the deposition/dissolution reaction, thereby impacting battery performance and safety. Various morphologies, including hemispherical, granular, columnar, and whisker-like structures, have been realized by modulating the deposition thermodynamics and kinetics. However, the intrinsic Li deposition structure matching the body-centered cubic (BCC) structure remains unexplored. Here, we first precisely controlled cubic Li deposits with (100) planes as the primary exposed surfaces via modulating anodic interface and optimizing deposition pressure, while demonstrating kinetically-driven morphology evolution and substrate-engineered epitaxial growth of cubic Li. These findings integrate the thermodynamic theory of crystal growth with interface engineering, completing the missing piece in the cubic Wulff construction of Li metal and providing a new paradigm for controlling the morphology of metal electrodes.}, archive = {J_ANGEW}, author = {Xingwei Sun and Yang Feng and Yong Lu and Zhenhua Yan and Kai Zhang and Jun Chen}, doi = {10.1002/anie.202506119}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506119}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Epitaxial electrodeposition of lithium metal in cubic wulff structures}, volume = {64}, year = {2025}, }
• (2025). Electronic modulation and active site exposure using c60 fullerenolamine enable high-performance alcohol oxidation on pd metallene catalysts. ANGEW, 64(32), e202506044. (www)

  @article{ , abstract = {The availability of active sites and the electronic structure of metal heterogeneous catalysts are crucial to maximize their catalytic performance. In this study, we describe a new and efficient catalyst system, C 60 fullerenolamine (FA)-modified Pd metallene (Pdene), and demonstrate that the FA molecules not only increase the active sites availability but also exert an electronic effect that enhances the catalytic performance of Pdene in alcohol oxidation reactions. Specifically, FA increases the electrochemical active surface area through dispersion, while its electron-withdrawing characteristics induce an electron-deficient surface on Pdene, which facilitates the adsorption of electron-rich intermediates (OH * ) and the desorption of electron-deficient poisonous intermediates (CO * ). The practical significance of this modification is demonstrated by achieving a 54.5% increase in mass activity and 46.3% enhancement in specific activity for ethanol oxidation relative to Pdene. Beyond these improvements, the FA-Pdene catalyst demonstrates exceptional operational stability, superior CO poisoning resistance, and enhanced C1 pathway selectivity. An in-depth analysis utilizing in-situ Fourier transform infrared spectroscopy, coupled with density functional theory calculations, offers valuable insights into how the FA ligand modulates the mechanistic pathways involved in ethanol oxidation processes. This fullerene-mediated catalytic effect could hold the key to unlocking the potential of the metal-based system.}, archive = {J_ANGEW}, author = {Shuqian Xie and Jiashuo Fu and Qi Huang and Wenhao Yang and Ao Yu and Yingying Yan and Zengyuan Li and Ping Peng and Yajun Yin and Haining Wang and Luis Echegoyen and Fang-Fang Li}, doi = {10.1002/anie.202506044}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202506044}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic modulation and active site exposure using c60 fullerenolamine enable high-performance alcohol oxidation on pd metallene catalysts}, volume = {64}, year = {2025}, }
• (2025). Engineering a multifunctional nanozyme platform for synergistic melanoma therapy: Integrating enzyme activity, immune activation, and low-temperature photothermal effects. ANGEW, 64(32), e202505911. (www)

  @article{ , abstract = {Melanoma is characterized by rapid growth and high invasiveness, resulting in an exceptionally high malignancy and a significant propensity for metastasis. Current therapeutic modalities, such as chemotherapy and radiotherapy, exhibit limited efficacy due to severe side effects and immunosuppressive effects. Consequently, the development of precise and effective integrated therapeutic strategies is of paramount importance. Here, we report a multifunctional and multienzyme active nanosystem (FeCP@PDA-GOx) that synergistically integrates starvation therapy, chemodynamic therapy, mild photothermal therapy (mPTT), and immunotherapy to achieve multidimensional therapeutic effects. This nanoplatform harnesses the enzymatic activities of glucose oxidase, peroxidase, oxidase, and catalase to enhance tumor microenvironment modulation and drug delivery efficiency, ultimately inducing ferroptosis in tumor cells. The system also establishes a positive feedback loop to further amplify its catalytic performance. Additionally, it effectively suppresses the expression of heat shock proteins in tumor cells, thereby augmenting the therapeutic efficacy of mPTT. Moreover, the system activates robust immune responses, suppressing lung metastasis and eliciting systemic antitumor effects to inhibit the growth of distal tumors. Experimental results demonstrate that this multifunctional nanoplatform exhibits exceptional therapeutic efficacy and safety in melanoma treatment, laying a solid foundation for the advancement of personalized medicine and intelligent therapeutic strategies.}, archive = {J_ANGEW}, author = {Qihang Ding and Haowei Liu and Lishan Yan and Liang Chen and Yu Chen and Jong Seung Kim and Ling Mei}, doi = {10.1002/anie.202505911}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505911}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering a multifunctional nanozyme platform for synergistic melanoma therapy: Integrating enzyme activity, immune activation, and low-temperature photothermal effects}, volume = {64}, year = {2025}, }
• (2025). Spin-state and clustering effects in fe-complex negolytes for near-neutral aqueous redox flow batteries. ANGEW, 64(32), e202505747. (www)

  @article{ , abstract = {Cost-effective redox-active materials are essential for advancing redox flow batteries (RFBs). Iron, with its abundance and suitability as a redox couple, is a promising candidate; however, achieving stable and fast redox reactions in aqueous RFBs remains a challenge. This study presents an Fe-based negolyte stabilized by a hexadentate ligand, where Fe–ligand bonds are enhanced through intermolecular interactions. The sulfonate-substituted Fe complex exhibits a formal potential of −0.44 V versus Ag/AgCl and an exceptionally high rate constant of 0.69 cm s −1 . Near-neutral RFBs incorporating 0.5 M Fe complex show excellent cycling stability, with no discernible capacity fading over 300 cycles. This performance is attributed to intermolecular hydrogen bonds that reinforce Fe–ligand coordination and promote the formation of stable trimeric clusters. Operando electrochemical Raman spectroscopy and density functional theory reveal that π-backdonation from Fe(II) to the imino-phenolate moiety further stabilizes the complex after reduction. In contrast, the hydroxyl-substituted complex exhibits inferior stability due to weaker hydrogen bonding and less pronounced π-backdonation. These findings underscore the importance of ligand design and intermolecular interactions in developing cost-effective, high-performance redox-active materials for aqueous RFBs.}, archive = {J_ANGEW}, author = {Donghwi Ko and Seongyeon Kwon and Jantakan Nedsaengtip and Yohan Kim and Yunseop Choi and Dongwook Kim and Xingyi Lyu and Ruchi Dixit and Yugang Zhang and Tao Li and Jongcheol Seo and Mu-Hyun Baik and Hye Ryung Byon}, doi = {10.1002/anie.202505747}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505747}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spin-state and clustering effects in fe-complex negolytes for near-neutral aqueous redox flow batteries}, volume = {64}, year = {2025}, }
• (2025). Maximizing accessible Fe–N–C sites on highly curved surfaces via chemical vapor deposition for boosting multienzyme-like activities of single-atom nanozymes. ANGEW, 64(32), e202505742. (www)

  @article{ , abstract = {Single-atom nanozymes (SAzymes) have emerged as a highly promising class of next-generation nanozymes. However, their widespread application remains significantly restricted by low reaction activity, primarily attributed to inefficient site utilization and sluggish reaction kinetics. Herein, we provided a novel approach to maximize accessible Fe–N–C sites on a highly curved surface (hFeSA) through chemical vapor deposition. This innovative catalyst demonstrated superior multienzyme-like activities compared to the conventional single iron atom catalyst (FeSA) with planar Fe–N 4 sites. Specifically, for peroxidase-like activity, the hFeSA exhibited a maximal reaction velocity of 1.91 × 10 −7 M s −1 , a catalytic constant of 5.78 s −1 , and a specific activity of 177.5 U mg −1 , which were 9.67-, 2.56-, and 9.56-fold higher than those of the conventional FeSA, respectively. Similarly, for oxidase-like activity, the hFeSA achieved a maximal reaction velocity of 2.84 × 10 −7 M s −1 , a catalytic constant of 4.3 s −1 , and a specific activity of 76.27 U mg −1 , representing enhancements of 11.73-, 3.11-, and 12.01-fold over FeSA, respectively. These results underscore the significant advantages of hFeSA in dramatically enhancing multienzyme-like activities. Furthermore, theoretical calculations revealed that single iron atoms anchored on curved surfaces can effectively lower the energy barrier, thereby enhancing the intrinsic activity of the Fe–N 4 sites and accelerating reaction kinetics.}, archive = {J_ANGEW}, author = {Yanjun Ji and Ying Wang and Huan Wang and Jinsen Bai and Jinsong Ren and Xiaogang Qu}, doi = {10.1002/anie.202505742}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505742}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Maximizing accessible Fe–N–C sites on highly curved surfaces via chemical vapor deposition for boosting multienzyme-like activities of single-atom nanozymes}, volume = {64}, year = {2025}, }
• (2025). A 19F-labeled probe for the chiral discrimination of thiols and thioethers. ANGEW, 64(32), e202505700. (www)

  @article{ , abstract = {Sulfur-containing compounds are pivotal in cellular processes such as redox balance and signal transduction. Traditionally, these compounds, especially thiols, are detected using fluorescence probes. However, these probes fall short in targeting thioethers due to their lower reactivity. Moreover, the chiral discrimination of thiols and thioethers typically relies on chromatographic methods, where separation-free, in situ strategies are highly desirable. To address this, we have developed a novel 19 F-labeled chiral platinum probe capable of distinguishing both thiols and thioethers. This technique generates distinct 19 F NMR signals that correspond to the stereoconfiguration of the analytes, enabling direct determination of their enantiocomposition. This method holds potential for integration into high-throughput workflows, boosting pharmaceutical and biological research by facilitating rapid, efficient chiral analysis of crucial compounds.}, archive = {J_ANGEW}, author = {Jiajin Weng and Guangxing Gu and Wei Zhang and Qi Jia and Yining Sun and Jian Wu and Yanchuan Zhao}, doi = {10.1002/anie.202505700}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505700}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A 19F-labeled probe for the chiral discrimination of thiols and thioethers}, volume = {64}, year = {2025}, }
• (2025). Modulation of lanthanide luminescence with the mechanical bond: Antenna-emitter confinement in a compact [2]Rotaxane. ANGEW, 64(32), e202505666. (www)

  @article{ , abstract = {Luminescent emitters based on lanthanide ions are of ubiquitous importance in the biological sciences, but typically need sensitization from a covalently attached adjacent chromophore – an “antenna” – to have suitable emission intensities. Here we show that the mechanical bond can be used to connect the antenna to the emitter, providing dynamic features and stimuli-responsiveness to the resulting assemblies. We outline a strategy to synthesize [2]rotaxanes capped with strong chelating groups, and establish that post-functionalization of the interlocked scaffold by lanthanide ion insertion is modular, high-yielding and straightforward. Photophysical studies revealed effective antenna-emitter energy transfer within the [2]rotaxane, and the sensitization mechanism as well as ring-thread dynamics were studied with spectroscopic and computational methods. The rotaxane was shown to have high selectivity toward Cu(II) ions, acting as an efficient turn-off sensor. This study validates the mechanical bond as a conjugation method between antennas and emitters, yielding otherwise hard-to-access and beneficial features to the resulting molecular systems.}, archive = {J_ANGEW}, author = {Anja Ramström and Daisy R. S. Pooler and Huseynagha Abasov and Monika Tomar and Stefano Crespi and Fredrik Schaufelberger}, doi = {10.1002/anie.202505666}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505666}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulation of lanthanide luminescence with the mechanical bond: Antenna-emitter confinement in a compact [2]Rotaxane}, volume = {64}, year = {2025}, }
• (2025). Origin of room temperature methanol synthesis over hcp-PdMo. ANGEW, 64(32), e202505634. (www)

  @article{ , abstract = {The hydrogenation of CO 2 to methanol has garnered significant interest with respect to the reduction of carbon emissions; however, the high temperatures and pressures typically required diminish the benefits of this approach. In this study, we report a hexagonal close-packed (hcp)-PdMo catalyst that exhibits the highest room temperature catalytic activity for CO 2 hydrogenation to methanol among reported catalysts, with 100% methanol selectivity and without any signs of deactivation. Structural analyses, which included various in situ and ex situ X-ray techniques and infrared spectroscopy, have revealed that Mo and Pd serve as the active sites for CO 2 adsorption and H 2 dissociation, respectively. The CO 2 hydrogenation reaction is facilitated at room temperature on the surface of the hcp-PdMo intermetallic catalyst, where the adjacently arranged Pd and Mo sites play important roles in methanol synthesis. Mechanistic studies, combined with density functional theory (DFT) calculations, have demonstrated that the reaction proceeds via a reverse water-gas shift and subsequent CO hydrogenation (R&C) pathway though a Pd-assisted Mo redox mechanism at room temperature. These findings not only reveal the origin of the reaction mechanism for methanol synthesis but also open a new direction for the design of highly efficient catalysts that function under mild conditions.}, archive = {J_ANGEW}, author = {Feilong Xing and Ruopeng Wang and Shiyao Wang and Hironobu Sugiyama and Chenyang Zhu and Masayoshi Miyazaki and Hideo Hosono and Masaaki Kitano}, doi = {10.1002/anie.202505634}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505634}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Origin of room temperature methanol synthesis over hcp-PdMo}, volume = {64}, year = {2025}, }
• (2025). Relay-enhanced electron transfer in triple-layer Ru@Ir@Pt Core–Shell nanoparticles for the ammonia oxidation reaction. ANGEW, 64(32), e202505616. (www)

  @article{ , abstract = {Ammonia oxidation reaction (AOR) is important for enabling the efficient use of NH 3 as a promising carrier for hydrogen storage and transportation. However, the catalytic activity of state-of-the-art Pt-based catalysts decreases significantly due to the strong adsorption of N species. In this study, a triple-layer core–shell structured Ru@Ir@Pt model catalyst was employed to demonstrate that the relay electron transfer strategy can decelerate the adsorption of N species and increase AOR activity, a process facilitated by the built-in electric field (BEF) induced by differing work functions that drive the sequential relay of charge transfer across the interfaces between different metals. In situ Fourier Transform Infrared (FTIR) spectroscopy revealed that AOR proceeds primarily via the N 2 H 4 pathway of the G–M mechanism. Both the experimental and theoretical simulation results confirm that relay electron transfer induced by a built-in electric field enables the outermost Pt electron-rich state to reduce the intensity of N adsorbed species and lower the energy barrier of rate-determining step in the AOR, resulting in excellent activity with a mass activity reaching up to 363.5 A g −1 . This value is 5.24 times higher than that of 20% Pt/C and significantly surpasses most previously reported catalysts. This work presents a novel material design approach for developing high-performance advanced ammonia oxidation electrocatalysts.}, archive = {J_ANGEW}, author = {Chenchen Wang and Jingtao Li and Yuan Yuan and Bo Ouyang and Zengsheng Guo and Cuiping Lin and Xiaodong Yang and Baotao Kang and Cuncheng Li and Yiqiang Sun and Kun Xu}, doi = {10.1002/anie.202505616}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Relay-enhanced electron transfer in triple-layer Ru@Ir@Pt Core–Shell nanoparticles for the ammonia oxidation reaction}, volume = {64}, year = {2025}, }
• (2025). Adjustable upcycling of polyethylene terephthalate to biodegradable polymer monomers by mn-catalyzed solvent switching strategy. ANGEW, 64(32), e202505490. (www)

  @article{ , abstract = {Waste plastics represent a new resource for the chemical industry. In this study, we demonstrate a solvent-switching strategy to upcycle waste polyethylene terephthalate (PET) into monomer terephthalic acid (TPA) and key bulk feedstocks for biodegradable polymers, such as lactic acid (LA) or glycolic acid (GA). PET undergoes rapid and mild depolymerization into its monomers TPA and ethylene glycol (EG) under the catalysis of a manganese complex. When methanol (MeOH) is used as the solvent, it undergoes selective dehydrogenative coupling with in situ generated EG, efficiently yielding TPA and LA with yields exceeding 98%. By replacing MeOH with tert -amyl alcohol ( t -AmOH), PET is quantitatively converted into TPA and GA. The PET conversion mechanism was elucidated through deuterium-labeling experiments and molecular model studies. This work presents a sustainable and innovative approach for upcycling waste PET into high-value products while opening a new route to synthesize biopolymer monomers, which are essential for developing chemically recyclable and biodegradable polymers, thereby advancing the production of sustainable single-use polymer products.}, archive = {J_ANGEW}, author = {Shun Zhang and Wenhao Xu and Xuan Zhao and Yifan Liu and Lei Yan and Xuehui Liu and Shimei Xu and Yu-Zhong Wang}, doi = {10.1002/anie.202505490}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505490}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Adjustable upcycling of polyethylene terephthalate to biodegradable polymer monomers by mn-catalyzed solvent switching strategy}, volume = {64}, year = {2025}, }
• (2025). Molecularly engineered circular additive with multisite desolvation for high-performance zinc ion battery. ANGEW, 64(32), e202505372. (www)

  @article{ , abstract = {Additive engineering can effectively relieve interface issues of aqueous zinc ion batteries (AZIBs), but most additives induce the sluggish interface kinetics and boosted polarization, especially at high current density and low temperature. Herein, the relationship between additive molecular structure and desolvation behavior is built by utilizing a series of circular and linear sugar molecules as prototypes, which systematically reveals molecular size, steric configuration, and electronic structure as design criteria for additives to achieve fast desolvation. As indicated by theoretical simulations and experiments, circular fructose (FRU) molecule with small size, quasi-planar adsorption configuration, and enhanced electron delocalization enables the compact electric double layer (EDL) with shorter Zn 2+ diffusion path and lower activation energy via multisite desolvation, thus obtaining the rapid interface kinetics and facilitating highly reversible zinc anode over a wide temperature range. Zn//Zn cell exhibits long cycle life exceeding 9500 h, and Zn//NVO cell maintains 83.92% high-capacity retention after 2480 cycles under 6.95 µL mg −1 lean electrolyte and 11.94 mg cm −2 high loading.}, archive = {J_ANGEW}, author = {Jinliang Yan and Haozhen Dou and Mengke Su and Mi Xu and Sitong Liu and Siqi Qin and Beinuo Zhang and Kai Zong and Lichao Tan and Xin Wang and Zhongwei Chen}, doi = {10.1002/anie.202505372}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505372}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecularly engineered circular additive with multisite desolvation for high-performance zinc ion battery}, volume = {64}, year = {2025}, }
• (2025). High-specificity spatiotemporal cholesterol detection by quadrature phase-shifted polarization stimulated raman imaging. ANGEW, 64(32), e202505038. (www)

  @article{ , abstract = {Visualizing cholesterol dynamics in living systems in situ remains a fundamental challenge in biomedical imaging. Although fluorescence microscopy requires bulky tags that perturb small molecule behavior, stimulated Raman scattering (SRS) microscopy enables label-free detection of CH-rich molecules. However, conventional SRS probes only polarized Raman components, limiting molecular specificity by seemingly overlapped peaks. Here, we extend SRS microscopy to achieve rapid, comprehensive detection of Raman tensor through quadrature phase-shifted polarization SRS (QP 2 -SRS) microscopy. This technique exploits the underlying molecular signatures by detecting both polarized and depolarized components of third-order nonlinear susceptibility χ (3) that originates from molecular structural features. We adopt a specialized optical delay line that rapidly alternates between parallel- and perpendicular-polarization states. QP 2 -SRS enables unprecedented distinction of similar molecular species in complex mixtures, demonstrating approximately 10× enhancement in chemical specificity and 5× improvement in analytical accuracy. This enhanced sensitivity enables real-time monitoring of lipid dynamics in living C. elegans and reveals component heterogeneity and morphological changes of LD in NAFLD livers. QP 2 -SRS creates new opportunities for investigating cholesterol-dependent biological processes in their native environment, with broad potential for chemical imaging with enhanced molecular specificity.}, archive = {J_ANGEW}, author = {Yongqing Zhang and Xinyu Deng and Siming Wang and Wenyu Zhou and Zhengyan Wu and Xiaobin Tang and Hyeon Jeong Lee and Delong Zhang}, doi = {10.1002/anie.202505038}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202505038}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-specificity spatiotemporal cholesterol detection by quadrature phase-shifted polarization stimulated raman imaging}, volume = {64}, year = {2025}, }
• (2025). Promoting the rate performances of weakly solvating electrolyte-based Lithium‒Sulfur batteries. ANGEW, 64(32), e202504898. (www)

  @article{ , abstract = {Lithium–sulfur (Li–S) batteries are promising next-generation energy storage devices due to their theoretical energy density of 2600 Wh kg −1 . Employing weakly solvating electrolyte (WSE) effectively alleviates the polysulfide shuttle effect and improves the cycling lifespan. However, the sulfur cathode kinetics in WSE is highly sluggish to render degraded rate performances. Herein, the sulfur cathode kinetics of WSE-based Li–S batteries is systematically investigated to help promote the rate performances in practical pouch cells. Concretely, the sluggish cathode kinetics of the previous charging process is identified as the main limitation for specific discharge capacity loss at high rates. Further polarization decoupling manifests activation polarization corresponding to polysulfide oxidation to elemental sulfur constitutes the dominant kinetic challenge. Accordingly, a redox mediation strategy is proposed to accelerate the charge-transfer kinetics of polysulfide oxidation in WSE. 3 Ah-level pouch cells cycle stably under a high rate of 0.2 C, and 5 Ah level pouch cells achieve an actual energy density of 470 Wh kg −1 . This work deepens the comprehension of the sulfur cathode kinetics in WSE and highlights the redox mediation strategy in achieving high-energy-density and high-rate Li–S batteries.}, archive = {J_ANGEW}, author = {Tian Jin and Xi-Yao Li and Meng Zhao and Shuai Feng and Zheng Li and Zi-Xian Chen and Hong-Jie Peng and Bo-Quan Li and Jia-Qi Huang}, doi = {10.1002/anie.202504898}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202504898}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting the rate performances of weakly solvating electrolyte-based Lithium‒Sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Beyond conventional doping: Sulfur-induced electronic and interfacial dynamics for advanced nitrate reduction. ANGEW, 64(32), e202504815. (www)

  @article{ , abstract = {Electrochemical nitrate reduction reaction (NO 3 − RR) to ammonia (NH 3 ) offers a sustainable route for NH₃ synthesis and environmental remediation, yet it is hindered by sluggish kinetics due to inefficient proton-coupled electron transfer (PCET) processes and inadequate electrocatalyst design. Conventional approaches primarily focus on the bulk electronic modulation of the electrocatalyst while neglecting interfacial water dynamics. Here, we propose a dual-functional sulfur-doping strategy in Co 3 O 4 (S-Co 3 O 4 ) to simultaneously enhance bulk conductivity and optimize interfacial proton transfer. Through innovative benzene sulfonyl chloride blocking experiment, in situ spectroscopic analyses, and kinetic isotope effect studies, we reveal that sulfur doping narrows the bandgap of Co 3 O 4 to enhance bulk charge transport while disrupting rigid hydrogen-bond network of water in the electric double layer; the weakly hydrogen-bonded H 2 O reduces the dissociation barrier and facilitates proton supply for nitrate hydrogenation. The proposed “electronic-interfacial synergy” strategy establishes a transformative paradigm for designing electrocatalysts in PCET-driven reactions, advancing sustainable energy conversion and environmental applications.}, archive = {J_ANGEW}, author = {Qinghao Zhang and Weilan Ye and Wenda Chen and Wei Zeng and Yingqi Xu and Bin Liang and Qixin Wang and Shuyuan Wu and Xiao Dong and Yongliang Li and Xiangzhong Ren and Huiqun Cao and Dantong Zhang and Xiaopeng Han and Shenghua Ye and Jianhong Liu and Qianling Zhang}, doi = {10.1002/anie.202504815}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202504815}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Beyond conventional doping: Sulfur-induced electronic and interfacial dynamics for advanced nitrate reduction}, volume = {64}, year = {2025}, }
• (2025). Proteome-wide ligand and target discovery by using β-nitrostyrene electrophiles: Supporting targeted protein degradation. ANGEW, 64(32), e202504813. (www)

  @article{ , abstract = {Bioconjugation chemistry has been a powerful avenue in expanding the repertoire of druggable proteome, as well as in identifying new E3 ligases to support targeted protein degradation (TPD). However, a large fraction of proteome remains inaccessible with existing covalent probes. Herein, we incorporated various electron-withdrawing groups into styrene derivatives and identified β -nitrostyrene as a cysteine-targeting reversible covalent warhead for target discovery. Through phenotypic screening and chemoproteomics platforms, we identified new ligandable sites such as C96 of SND1, C110 of PTGES2, modulating cell proliferation in an acute myeloid leukemia cell line. Moreover, incorporation of this warhead into the BRD4 inhibitor (+)-JQ1 demonstrated that the covalent handle engages the novel E3 ligase tripartite motif-containing 28 (TRIM28) at Cys232 residue, thereby promoting the targeted degradation. Notably, when transplanted into other protein-targeting ligands, the β -nitrostyrene warhead effectively induced protein degradation of EGFR L858R/T790M/C797S , PDE5, BTK, LRRK2, and BCR-ABL/c-ABL without eliciting a hook effect. Importantly, the degraders demonstrate significantly enhanced antcancer effects compared to corresponding inhibitors. To our knowledge, this is the first report of small-molecular degraders engaging TRIM28 to support targeted protein degradation, and provides a rational pathway for design and development of potent monovalent degraders.}, archive = {J_ANGEW}, author = {Xinyao Ouyang and Xiaomeng Chai and Lei Huang and Yubin Chen and Shengrong Li and Weizhen Huang and Yifang Li and Ke Ding and Tongzheng Liu and Yi Tan and Zhengqiu Li}, doi = {10.1002/anie.202504813}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202504813}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proteome-wide ligand and target discovery by using β-nitrostyrene electrophiles: Supporting targeted protein degradation}, volume = {64}, year = {2025}, }
• (2025). Patch-clamp-like micropipette electrode with exterior and interior interfaces for simultaneous monitoring of extracellular and intracellular serotonin across neuron. ANGEW, 64(32), e202504408. (www)

  @article{ , abstract = {Simultaneous monitoring of intracellular and extracellular serotonin (5-HT) across five orders of magnitude is crucial for understanding 5-HT-related diseases. Here, we created a patch-clamp-like micropipette electrode with double sensing interfaces, in which gold nanoparticles were coated onto exterior surface and conductive hydrogel was in situ polymerized by designed monomer to form interior interface. Furthermore, we engineered serotonin binding protein (SerBP) as recognition element to develop open-circuit potentiometric 5-HT sensor and modulated SerBP to enhance dissociation constant toward 5-HT through key residue mutation to broaden the linear ranges by five orders of magnitude for both intracellular and extracellular 5-HT recording. Meanwhile, the designed noninsertion mode together with zero potential detection caused minimal cell damage, thus significantly prolonged the recording duration. Using this powerful tool, we first discovered 5-HT transporter reversed function to release 5-HT before intracellular exocytosis enhanced, and together, through the release–reuptake–metabolism cycle, dynamically regulate the concentration of 5-HT with the development of seizure.}, archive = {J_ANGEW}, author = {Jie Liu and Qin Zhou and Yuandong Liu and Yang Tian}, doi = {10.1002/anie.202504408}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202504408}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Patch-clamp-like micropipette electrode with exterior and interior interfaces for simultaneous monitoring of extracellular and intracellular serotonin across neuron}, volume = {64}, year = {2025}, }
• (2025). Lattice distortion promoting wavelength-tunable emissions in Cu(I)-based halides for thermography and anti-counterfeiting. ANGEW, 64(32), e202504406. (www)

  @article{ , abstract = {Low dimensional hybrid metal halides as a chemically tunable platform achieve multi-functional optical applications with versatile luminescence mechanisms. Herein, we design and prepare Cu(I)-based hybrid halide (DMAP)Cu 3 I 4 (DMAP = 4-Dimethylaminopyridine), with ambient temperature-induced photoluminescence evolution from red to near-infrared emissions. The in situ variable-temperature crystallographic study reveals lattice distortion with more disordered [Cu 3n I 4n ] n− units appear at high temperature, further indicating that the observed wavelength-tunable emission is attributed to transitions from Cu cluster center to halogen-to-metal charge transfer. Thus, (DMAP)Cu 3 I 4 shows a compelling thermometric precision (high sensitivities of 0.0001–0.6 K −1 ) at a wide temperature range of 80–300 K. In particular, the remote thermography is established with a high spatial resolution of −20 lp mm −1 by processable thin films. These findings enhance the potential for molecular-level illumination in Cu(I)-based halides and contribute to the exploration of their optoelectronic properties.}, archive = {J_ANGEW}, author = {Kai Han and Shuai Zhang and Jiance Jin and Yongsheng Sun and Yuzhen Wang and Zhiguo Xia}, doi = {10.1002/anie.202504406}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202504406}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lattice distortion promoting wavelength-tunable emissions in Cu(I)-based halides for thermography and anti-counterfeiting}, volume = {64}, year = {2025}, }
• (2025). Insights into the mechanisms behind structural repair of spent layered cathode materials for lithium-ion batteries. ANGEW, 64(32), e202504382. (www)

  @article{ , abstract = {Structural repair is a vital step in the direct recycling of spent LiNi x Co y Mn z O 2 lithium-ion batteries, yet its underlying mechanisms remain insufficiently clear. Herein, the thermal solid-state structural repair of spent LiNi 0.6 Co 0.2 Mn 0.2 O 2 (NCM622) layered cathode material is systematically investigated. Through multiscale techniques combining XRD, XAS, and 6 Li solid-state NMR, we identify the structural degradation in spent NCM622 and monitor both long- and short-range structural evolution during repair. Our findings reveal that degradation predominantly occurs through Ni migration into Li octahedral sites, while Co and Mn demonstrate relatively lower occupancies in the Li layer. Such occupancies are primarily responsible for structural disorder and cubic-symmetry domain formation within the spent material. The repair process is demonstrated to involve re-lithiation, oxygen capture, increased transition metal (TM) oxidation states, and the migration of TM ions from the Li layer back to the TM layer, followed by cation diffusion. Both temperature and lithium compensation ratio are identified as critical factors promoting these processes. Capacity recovery studies show a strong correlation between reduced TM occupancy in the Li layer and improved electrochemical performances. These insights allow us to move beyond conventional phase-transition perspectives, offering an atomic-level understanding of structural degradation and repair mechanisms in spent layered cathode materials.}, archive = {J_ANGEW}, author = {Shuaiwei Liu and Hao Liu and Arseniy Bokov and Mohammad Jaleh and Hang Li and Sylvio Indris and Oleksandr Dolotko and Aleksandr Kalinko and Edgar Eduardo Villalobos Portillo and Carlo Marini and Thomas Bergfeldt and Michael Knapp and Helmut Ehrenberg}, doi = {10.1002/anie.202504382}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202504382}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insights into the mechanisms behind structural repair of spent layered cathode materials for lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). An engineered multivalent TMV nanodisk platform for modulating integrin clustering and cell signaling. ANGEW, 64(32), e202503793. (www)

  @article{ , abstract = {Clustering of cell-surface receptors is essential for initiating signaling cascades and regulating cellular functions. Multivalent ligands with high receptor affinity offer powerful tools for manipulating these processes and advancing therapeutic strategies. However, designing easily modifiable, stable, and uniformly structured multivalent ligands remains a significant challenge. In this work, we present a novel protein-based platform derived from modified tobacco mosaic virus (TMV) coat protein, which assembles into a stable, discoid scaffold capable of displaying up to 34 ligands with evenly distributed binding sites. By introducing the T103C modification, we achieve exceptional structural stability, allowing the platform to maintain integrity across a broad pH range (5–11) and during long-term storage (up to 6 months). Using the integrin-binding peptide SPPEPS as a model, we generate a multivalent TMV-SPPEPS that exhibits a 453-fold increase in integrin affinity over the monomeric peptide and can simultaneously cluster up to seven integrins. This multivalent platform promotes integrin clustering on cell surfaces, triggering mesenchymal stem cell chondrogenesis and effectively alleviating osteoarthritis in a rat model. These results highlight the potential of the TMV nanodisk as a versatile and stable platform for controlling receptor clustering and modulating intracellular signaling in diverse biomedical applications.}, archive = {J_ANGEW}, author = {Haobo He and Yihao Zhou and Mingming Du and Fanmeng Zeng and Yuheng Cao and Jiang Jiang and Guangcun Chen and Qiangbin Wang}, doi = {10.1002/anie.202503793}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202503793}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An engineered multivalent TMV nanodisk platform for modulating integrin clustering and cell signaling}, volume = {64}, year = {2025}, }
• (2025). Boosting ultra-wide temperature sodium-bromine batteries via chlorine-bromine activation. ANGEW, 64(32), e202503752. (www)

  @article{ , abstract = {The development of high-energy-density batteries operable over a wide temperature range is critical for sustainable energy storage. Sodium-chlorine (Na-Cl 2 ) batteries show promising high theoretical energy densities but face significant safety challenges due to gaseous chlorine, particularly at high temperatures. Replacing Cl 2 with liquid Br 2 to construct a new Na-Br 2 battery mitigates gas risks but introduces issues with sluggish reaction kinetics and high-temperature volatility. To overcome these limitations, we developed a revolutionary Na-Br(+) battery based on the activated Br + by Cl − anions, pioneering a stabilized redox process via Br − /BrCl 2 − conversion. The introduction of Cl − enhances the reversibility kinetics of bromine species and facilitating the activation of Br + through polyanions BrCl 2 − , enabling additional electron transfer pathways. The Na-Br(+) battery achieves impressive low polarization (0.18 V) and exhibits wide-temperature functionality (−60 °C to 60 °C) with a cycle life exceeding 400 cycles. This heterogeneous halogen activation strategy addresses key gas safety limitations and advances the practicality of metal-halogen batteries.}, archive = {J_ANGEW}, author = {Wenting Feng and Jianhang Yang and Xinru Wei and Chenyu Ma and Junwei Han and Guanzhong Ma and Han Wang and Debin Kong and Linjie Zhi}, doi = {10.1002/anie.202503752}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202503752}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting ultra-wide temperature sodium-bromine batteries via chlorine-bromine activation}, volume = {64}, year = {2025}, }
• (2025). Direct synthesis of vinylene-linked conjugated polymers by selective Methyl/Methylene C─H activation on gold surfaces. ANGEW, 64(32), e202503303. (www)

  @article{ , abstract = {Vinylene (C═C) linkage facilitates the distribution of highly conjugated electrons along the polymer chain, thereby playing a crucial role in the development of conductive polymers for promising applications in organic electronics. Directly connecting two methyl groups to construct a vinylene linkage would streamline the synthesis process considerably, reducing the number of reaction steps required. However, reactions through alkyl groups normally form C─C single bonds as linkages. Achieving vinylene bonds via further dehydrogenation remains a significant challenge. Here, we demonstrate the successful synthesis of vinylene linkages by selectively activating methyl/methylene C─H bonds using the predesigned monomers bearing methylthiophenes on Au(111) and Au(110) surfaces. Noncontact atomic force microscopy confirms the formation of vinylene linkage by bond-resolved imaging on both surfaces, achieving a vinylene linkage yield of 97%. Density functional theory calculations and control experiments reveal that the strong adsorption of the thiophene ring on the gold substrate effectively reduces the energy barriers for methyl and methylene C─H dissociation, enabling the two-step dehydrogenation for the formation of vinylene-linked polymers with up to 27 units. Our findings present a novel strategy for polymerization or oligomerization via vinylene linkages on surfaces.}, archive = {J_ANGEW}, author = {Qi Zheng and Li Huang and M. R. Ajayakumar and Wen-Han Dong and Jin-Jiang Zhang and Yan Li and Xiao Chang and Yao Xiao and Xiaoshuai Fu and Yixuan Gao and Zhihai Cheng and Ji Ma and Shixuan Du and Xiao Lin and Xinliang Feng and Hong-Jun Gao}, doi = {10.1002/anie.202503303}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202503303}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct synthesis of vinylene-linked conjugated polymers by selective Methyl/Methylene C─H activation on gold surfaces}, volume = {64}, year = {2025}, }
• (2025). Selective production of acetylene from the C─C coupling reaction of CH4 with CO2 mediated by Ta2O2+ cluster cations. ANGEW, 64(32), e202503132. (www)

  @article{ , abstract = {Coconversion of methane and carbon dioxide to C 2 hydrocarbons via the C CH4 ─C CO2 coupling reaction is of great significance to mitigate greenhouse effect and develop an alternative route for manufacture of important industrial feedstocks (e.g., C 2 H 2 ), however, it has not yet been achieved so far owing to the difficulty in breaking both of the C═O bonds in CO 2 as well as the precise control of sequential elementary reactions targeted for C 2 hydrocarbons. Herein, by using the tantalum oxide Ta 2 O 2 + as an active cluster, an unprecedented C CH4 ─C CO2 coupling reaction of CH 4 with CO 2 to exclusively produce the C 2 hydrocarbon of C 2 H 2 has been successfully realized even at room temperature by the state-of-the-art mass spectrometry. The in situ reconstruction from Ta─O─Ta cluster skeleton to tantalum carbide Ta─C─Ta experienced upon the prereaction with CH 4 is critical to delicately control the sequential elementary reactions targeted for C 2 H 2 generation. This finding not only leads to a breakthrough in the field of gas-phase and condensed-phase chemistry wherein the C 2+ oxygenated compounds were the mainstream products for C CH4 ─C CO2 coupling of CH 4 with CO 2 , but also explores a new active structure and a novel reaction mechanism beneficial for selective production of C 2 hydrocarbons from coconversion of CH 4 and CO 2 .}, archive = {J_ANGEW}, author = {An Zhao and Yan-Xia Zhao and Qian Li and Xi-Guan Zhao and Qing-Yu Liu and Sheng-Gui He}, doi = {10.1002/anie.202503132}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202503132}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective production of acetylene from the C─C coupling reaction of CH4 with CO2 mediated by Ta2O2+ cluster cations}, volume = {64}, year = {2025}, }
• (2025). Breaking bonds at Tin(II): Reductive or oxidative addition?. ANGEW, 64(32), e202503050. (www)

  @article{ , abstract = {Here, the addition of H─H, Be─Be, B─B, and B─H bonds to Sn II is studied by experimental and theoretical means. We report the first examples of B─B and Be─Be bond additions to a main group metal centre, along with the first example of borazine B─H bond addition to any element of the Periodic Table. Quantum chemical calculations suggest that the classification of these reactions as prototypical “oxidative” addition processes may be misleading and that a more nuanced description is warranted.}, archive = {J_ANGEW}, author = {Maximilian Dietz and Josef T. Boronski and Amelia M. Swarbrook and Simon Aldridge}, doi = {10.1002/anie.202503050}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202503050}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking bonds at Tin(II): Reductive or oxidative addition?}, volume = {64}, year = {2025}, }
• (2025). “Rigid exterior, soft interior” design enables high-voltage polyether electrolytes for quasi-solid-state batteries. ANGEW, 64(32), e202502728. (www)

  @article{ , abstract = {Polyether electrolytes with high Li + conductivity and excellent interfacial contact have garnered significant attention. Yet further applications of such electrolytes in high-voltage lithium metal batteries are severely hindered by the instability of the electrolyte and electrolyte/electrodes interphases. Here, we report a novel high-voltage polyether electrolyte with a “rigid exterior, soft interior” design, which involves a 3D F-contained network as a rigid exterior framework, and a unique solvation structure with intensified Li + -anion coordination as a soft interior within the framework. The achieved electrolyte demonstrates an ionic conductivity of 1.13 mS cm −1 at 25 °C, a Li + transference number of 0.85, and an extended electrochemical stability window of over 5 V. Besides, such a designed polyether electrolyte further induces salt-philic, solvent-phobic interfacial films for stabilizing electrolyte/electrode interphases. An exceptional cyclability in a Li||Li cell for over 4000 h, and a preferable capacity and cyclability in even 4.6 V Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811) quasi-solid-state batteries (QSSBs) are demonstrated. Meanwhile, the resulting 4.3 V Li||LiNi 0.5 Co 0.2 Mn 0.3 O 2 QSSB shows a Coulombic efficiency of ∼100% and an extremely high capacity retention of 95.4% after 600 cycles at 3C. A capacity retention of over 96.3% after 400 cycles at 1C are further realized in 4.5 V Li||NCM811 QSSB.}, archive = {J_ANGEW}, author = {Song Duan and Lifen Zhang and Yun Zheng and Zhenghao Li and Zewen Liu and Can Liao and Hongyao Wang and Wei Yan and Jiujun Zhang}, doi = {10.1002/anie.202502728}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202502728}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Rigid exterior, soft interior” design enables high-voltage polyether electrolytes for quasi-solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). Ionic liquid accelerates electrochemically driven single-molecule oxidative coupling. ANGEW, 64(32), e202502724. (www)

  @article{ , abstract = {Molecular adsorption covers a broad spectrum of chemical processes and device fabrications at solid/liquid interfaces. The unraveling of the underlying mechanisms relies on regulating molecular adsorption. However, achieving such regulation at the single-molecule level remains a challenge. Herein, we utilized a combined ionic liquid and scanning tunneling microscope break junction methods to tune single 4-(pyridin-4-yl)aniline molecules gradually from the flat configuration to the upright one and found that only the upright configuration can trigger the oxidative coupling. Experimental and theoretical findings demonstrated that the ionic liquid reduced the electron density of the Au electrode, giving rise to the evolution of the interaction between molecule and electrode from the Au-π dominated coupling to the Au-σ dominated one. This work will inspire the exploration of strategies that can control the molecular assembly, accelerate the chemical reaction, and promote the fabrication of organic devices.}, archive = {J_ANGEW}, author = {Jiao Xun and Jia-Xin Chen and Tong-Ruo Diao and Lai-Ke Chen and Yu-Ling Zou and Chen-Cong Luo and Jia Shi and De-Yin Wu and Yang Yang}, doi = {10.1002/anie.202502724}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202502724}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ionic liquid accelerates electrochemically driven single-molecule oxidative coupling}, volume = {64}, year = {2025}, }
• (2025). Flexible-linked oligomeric acceptors: Precise synthesis and enhanced Photovoltaic/Mechanical properties for stretchable devices. ANGEW, 64(32), e202502596. (www)

  @article{ , abstract = {Intrinsically stretchable organic solar cells (IS-OSCs) are among the most promising technologies for wearable power applications. However, the development of electron acceptors that simultaneously meet the demands for high performance and mechanical stretchability remains a significant challenge. In this study, we creatively synthesized three oligomeric acceptors with flexible linkers (2YF-Br, 4YF-T, and 6YF-BT) and achieved both high efficiency and mechanical robustness in IS-OSCs. Benefiting from an improved fibrous morphology and excellent charge dynamics, rigid OSCs based on 4YF-T demonstrated a superior power conversion efficiency (PCE) of 18.76%, outperforming devices based on 2YF-Br and 6YF-BT. Additionally, the thermal stability of rigid OSCs progressively improved with increasing molecular weight, from 2YF-Br to 6YF-BT. Furthermore, the enlarged molecular weight of the acceptors significantly enhanced mechanical stretchability, with crack-onset strain (COS) values of 16.11%, 20.62%, and 25.92% for 2YF-Br, 4YF-T, and 6YF-BT, respectively. Importantly, as molecular weight increased, the mechanical robustness of IS-OSCs also improved, with 6YF-BT-based devices achieving remarkable stretchability (strain at PCE 80% = 35%). This study introduces a new class of high-molecular-weight acceptors with well-defined structures, paving the way for the advancement and practical application of IS-OSCs in wearable electronics.}, archive = {J_ANGEW}, author = {Yafei Ding and Waqar Ali Memon and Shilong Xiong and Di Zhang and Zhi Wang and Zhiqiang Wang and Dongsheng Qiu and Zihao Deng and Ming Shao and Feng He}, doi = {10.1002/anie.202502596}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202502596}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flexible-linked oligomeric acceptors: Precise synthesis and enhanced Photovoltaic/Mechanical properties for stretchable devices}, volume = {64}, year = {2025}, }
• (2025). Ternary potassium-bismuth-telluride intermetallic support promotes electrochemical stability in potassium metal anodes. ANGEW, 64(32), e202502213. (www)

  @article{ , abstract = {We employed accumulative roll bonding to fabricate self-standing metallurgical composite of in situ formed alkaline potassium-bismuth-telluride intermetallic K 2 (Bi 2/6 Te 3/6 Vac 1/6 ) embedded in potassium metal. This newly discovered thermodynamically stable potassiophilic crystal, termed “KBT”, is fcc antifluorite with K 2 Te archetype. Symmetric cells achieve 880 h of cycling at 0.5 mA cm −2 and 0.5 mAh cm −2 . Potassium metal battery (KMB) with Prussian blue (PB) cathode in carbonate electrolyte retains 80% capacity after 200 cycles at 1C. In ether-based electrolyte with organic cathode, it achieves 80% retention after 900 cycles at 2C. Combined synchrotron X-ray nano-tomography, cryogenic-focused ion beam microscopy (Cryo-FIB) and sputter-down X-ray photoelectron spectroscopy (XPS) demonstrate uniform electrodeposits, versus baseline of potassium filaments intermixed with pores and coarse SEI. Binary K 3 Bi-K and K 2 Te-K intermetallic supports also provide improved electrochemical performance, albeit to lesser extent. Multiscale simulation provides insight into role of support structure in adatom energetics, film nucleation, early-stage SEI morphology and interfacial stability.}, archive = {J_ANGEW}, author = {Rohit Raj and Yixian Wang and Dean Yen and Aditya Singla and Jiefeng Diao and Hongchang Hao and Varun R. Kankanallu and Bairav S. Vishnugopi and Mingyuan Ge and John Watt and Graeme Henkelman and Yu-chen Karen Chen-Wiegart and Partha P. Mukherjee and David Mitlin}, doi = {10.1002/anie.202502213}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202502213}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ternary potassium-bismuth-telluride intermetallic support promotes electrochemical stability in potassium metal anodes}, volume = {64}, year = {2025}, }
• (2025). Energetics modulation for efficient and stable n–i–p perovskite solar cells. ANGEW, 64(32), e202502117. (www)

  @article{ , abstract = {The operational stability of n–i–p perovskite solar cells (PSCs) under heat, air, and humidity has notably improved over recent years. Yet, performance degradation under light and voltage bias remains a concern for their commercial deployment. One of the main causes of such degradation relates to mobile ions in the perovskite film, which can trigger ion migration and self-accelerating chemical degradation. Here, we propose an energetics modulation strategy by developing the electron-withdrawing pyridinecarboxaldehyde oxime (PO) ligand for FAPbI 3 -based perovskites. The introduction of PO ligands increases the ionization potential of the perovskite, inhibiting the generation of mobile ions during the crystallization process and subsequent device operation. Furthermore, this additive promotes the reaction between PbI 2 and organic salts, which can help to regulate the energy level of perovskite and facilitate charge transport to the contact stacks. As a result, the optimized n–i–p PSCs exhibit a high efficiency of 26.13% and maintain over 88% of their initial efficiency after 1000 h maximum power point (MPP) tracking test under 1 sun illumination. This work underlines the importance of energetics modulation for inhibiting intrinsic perovskite degradation that cannot be achieved by mere device encapsulation.}, archive = {J_ANGEW}, author = {Heng Liu and Qiongqiong Lu and Yihan Zhang and Min Li and Jiantao Wang and Suyang Sun and Yao Zhang and Haoqing Zhang and Jia Liu and Pengfei Yue and Zhiyuan Zhu and Yu Chen and Fangze Liu and Guoshang Zhang and Stefaan De Wolf and Jing Wei}, doi = {10.1002/anie.202502117}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202502117}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Energetics modulation for efficient and stable n–i–p perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). A platform for the development of highly red-shifted azobenzene-based optical tools. ANGEW, 64(32), e202501779. (www)

  @article{ , abstract = {Azobenzenes are versatile photoswitches that can be used to generate elaborate optical tools, including photopharmaceuticals. However, the targeted application-guided design of new photoswitches with specific properties remains challenging. We have developed synthetic protocols for derivatives of the dfdc (di- ortho- fluoro-di- ortho- chloro) azobenzene scaffold with chemical alterations in the para -/ ortho -positions and performed an in-depth study into the effects of their structures on their photophysical properties with an emphasis on the n → π* absorption band using NMR, UV–vis, and X-ray analysis. The data was used to establish and validate a computational approach that allows to compute realistic UV–vis spectra by combining TD-DFT excited-state calculations from 6000 thermally accessible structures generated through MD simulations while considering the high structural flexibility of ortho -substituted azobenzenes. We added 15 new visible light-operated photoswitches to the toolbox for the development of optical devices with relaxation rates across multiple orders of magnitude and identified several examples with stronger bathochromic shifts than the dfdc azobenzene lead structure. Our combined experimental and computational study forms the foundation for the advanced in silico design and synthesis of new highly red-shifted photoswitches. To showcase the potential of dfdc azobenzenes for the development of chemical tools, we synthesized dfdc -OptoBI-1 and demonstrated its biological activity as a red light-operated activator of TRPC6 channels in HEK293 cells.}, archive = {J_ANGEW}, author = {Kyra Lützel and Henryk Laqua and Manjima B. Sathian and Benedikt Nißl and Judit Katalin Szántó and Christina-Anna Senser and Gökcen Savasci and Lars Allmendinger and Bilal Kicin and Vincent Ruf and Dominik Kammerer and Theobald Lohmüller and Konstantin Karaghiosoff and Ahmed M. Ali and Ursula Storch and Michael Mederos y Schnitzler and Christian Ochsenfeld and David B. Konrad}, doi = {10.1002/anie.202501779}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202501779}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A platform for the development of highly red-shifted azobenzene-based optical tools}, volume = {64}, year = {2025}, }
• (2025). Selective electrochemical CO2 reduction to ethylene or ethanol via tuning *OH adsorption. ANGEW, 64(32), e202501773. (www)

  @article{ , abstract = {Selective electrocatalytic reduction of carbon dioxide (CO 2 RR) into ethylene (C 2 H 4 ) or ethanol (C 2 H 5 OH) is a high challenge. In this study, the rational manipulation of Cu defect sites was realized for the selective formation of C 2 H 5 OH and C 2 H 4 . Low-coordination amorphous and medium-coordination grain-boundary Cu defect sites with different *OH affinity were found to play a decisive role in the selective protonation of CH 2 CHO*. In particular, grain-boundary-rich Cu (denoted as Cu-1) that weakly adsorbed *OH and CH 2 CHO* favored the protonation on β-C of CH 2 CHO*, leading to the selective production of C 2 H 5 OH. In contrast, amorphous Cu defect sites (denoted as Cu-3) showed strong *OH adsorption and then strong CH 2 CHO* adsorption, facilitating C−O breaking and C 2 H 4 formation. In the membrane electrode assembly (MEA) configuration, a remarkably high full-cell energy efficiency (EE) of 29.0 % for C 2 H 5 OH on Cu-1 and an impressive high full-cell EE of 25.6 % for C 2 H 4 on Cu-3 were observed. In addition, a C 2 H 4 Faradaic efficiency (FE) of 63.4±1.5 % was achieved on Cu-3 at a notable current of 12.5 A with a 25 cm −2 MEA configuration. These results provided crucial insights into the significance of defect sites in manipulating the adsorption of *OH for the selective production of C 2 H 4 or C 2 H 5 OH.}, archive = {J_ANGEW}, author = {Dazhong Zhong and Qiang Fang and Runxin Du and Yaxin Jin and Chen Peng and Dongfang Cheng and Tan Li and Tao Zhao and Sheng Zhang and Yao Zheng and Qiang Zhao and Yuhan Sun and Jinping Li}, doi = {10.1002/anie.202501773}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202501773}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective electrochemical CO2 reduction to ethylene or ethanol via tuning *OH adsorption}, volume = {64}, year = {2025}, }
• (2025). Library of stereoregular polythioesters for stereocomplex formation enabled by isomerization-driven cationic ring-opening polymerization. ANGEW, 64(32), e202501485. (www)

  @article{ , abstract = {Supramolecular stereocomplexation is an important tool to advance sustainable polymers, and oxygen-containing polymers represent the most widely studied materials for stereocomplexation. However, the sulfur-containing analogues, a newly emerged class of sustainable polymers, remain essentially unexplored because of a significant challenge encountered in the synthesis of stereoregular polymers and relatively low supramolecular interaction. In this contribution, by the utilization of [Et 3 O] + [B(C 6 F 5 ) 4 ] − as a metal-free cationic initiator, controlled isomerization-driven ring-opening polymerizations (IROPs) of nine examples of chiral five-membered thionolactones have been achieved with free or suppressed racemization via unique monomer-stabilized S N 2 propagation mechanism, which allows an unprecedented access to a library of new stereoregular polythioesters with high isotacticities (80.0%–99.5%). The investigations into structure–stereocomplexation relationship led to the disclosure of two new polythioester stereocomplexes with high melting temperatures (117.0–161.0 °C). The fundamental aspects of stereocomplex formation mechanism and critical factors that affect stereocomplexed ability have also been revealed.}, archive = {J_ANGEW}, author = {Pengjun Yuan and Yongliang Xia and Xi Zhang and Yangyang Sun and Yifeng Chen and Miao Hong}, doi = {10.1002/anie.202501485}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202501485}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Library of stereoregular polythioesters for stereocomplex formation enabled by isomerization-driven cationic ring-opening polymerization}, volume = {64}, year = {2025}, }
• (2025). Enhanced cycling performance of li-rich oxide cathode via a vaccine effect. ANGEW, 64(32), e202500183. (www)

  @article{ , abstract = {Multi-component incorporation and its inoculated gradient disorder structure can greatly modify the properties of materials. However, the contribution of the inoculated surface gradient disorder structure on the Li-rich cathodeswith distinctive integrated structure of LiMO 2 (M = Ni, Mn, Co) and Li 2 MnO 3 has been overlooked. Here, we reveal a vaccine effect of surface gradient disorder structure, demonstrating its significant improvement on the cycling performance of inoculated Li 1.2 Mn 0.6 Ni 0.2 O 2 . The inoculated Li 1.2 Mn 0.6 Ni 0.2 O 2 exhibits an initial coulombic efficiency of 85% and maintains ultra-high stability with 100% capacity retention after 500 cycles. Furthermore, it delivers a capacity of 154.5 mAh g −1 with 84.2% retention after 900 cycles at current density of 200 mA g −1 . Through a combination of electrochemical analysis and theoretical simulations via the basic Nernst equations, we demonstrate that the inoculated gradient disorder structure changes the thermodynamic and kinetic parameters governing the lattice oxygen redox process, which follows three sequential steps O 2− →O 2 2− →O 2− →O 2 . This structural modification reconstructs the lattice oxygen redox, specially enhancing the electrode potential of the O 2− →O 2 step and reducing the reaction rate of O 2− →O 2 2− →O 2 − of Li 1.2 Mn 0.6 Ni 0.2 O 2 . These findings bring a novel perspective on the conventional foreign element incorporation strategy, providing valuable insights to support the continued development of Li-ion batteries.}, archive = {J_ANGEW}, author = {Kai Yao and Yaowen Wang and Xiaoyan Xie and Miao Li and Ao Zhang and Xin Zhang and Guangshe Li and Liping Li}, doi = {10.1002/anie.202500183}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202500183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced cycling performance of li-rich oxide cathode via a vaccine effect}, volume = {64}, year = {2025}, }
• (2025). Dynamic photoacoustic imaging of mobile Cu(II) in vivo via catalytic radical cation formation. ANGEW, 64(32), e202500149. (www)

  @article{ , abstract = {Copper dyshomeostasis is associated with various diseases, making in vivo spatiotemporal imaging of mobile Cu(II) dynamics crucial for understanding pathophysiological mechanisms. However, imaging mobile Cu(II) dynamics remains a long-standing challenge due to the limitations of conventional probes in distinguishing between mobile and bound Cu(II). Herein, we developed a design strategy based on catalytic arylamine radical cation formation, enabling the creation of photoacoustic probes with superior sensitivity and micron-resolution imaging capabilities in the short-wave infrared region, specifically in response to mobile Cu(II). In vivo imaging of the brains of Parkinson's disease model mice revealed significant alternations in mobile Cu(II) levels within the cerebral cortex and cerebellar lobules during early disease stages, suggesting that these regions are particularly vulnerable to Cu(II) accumulation in early Parkinson's disease. These findings underscore the significant potential of these probes for investigating mobile Cu(II) dynamics and their role in physiological and pathological processes.}, archive = {J_ANGEW}, author = {Zhiyong Jiang and Qian Sun and Xiaoqing Wang and Yuncong Chen and Fang Liu and Jing Zhao and Zijian Guo and Zhipeng Liu}, doi = {10.1002/anie.202500149}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202500149}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic photoacoustic imaging of mobile Cu(II) in vivo via catalytic radical cation formation}, volume = {64}, year = {2025}, }
• (2025). Quenching-induced three-phase heterostructured catalysts for oxygen electrocatalysis with lattice oxygen participation. ANGEW, 64(32), e202422451. (www)

  @article{ , abstract = {Lattice oxygen-mediated mechanism of oxygen evolution reaction can overcome the scaling relations-induced limitations imposed by conventional adsorption evolution mechanism, but faces challenges in maximizing activation of lattice oxygen species. The flexible structure of three-phase heterostructured catalysts provides the possibility for high-performance electrocatalysis, yet still face the bottleneck of synthesis difficulty and insufficient regulation. Herein, a facile quenching route is proposed for the synthesis of core-shell catalysts, and the influence mechanism of three-phase heterostructure on quenching engineering is elucidated. High-temperature LaNiO 3 nanoparticles are quenched in FeSO 4 solution to construct a LaNiO 3 /Fe(OH) 3 core-shell structure by inducing rapid hydrolysis of Fe 2+ . The differential thermal expansion coefficient between LaNiO 3 and Fe 2 O 3 , as well as the three-phase interfaces composed of core-shell structure and amorphous/crystalline phases in Fe 2 O 3 shell, result in significant surface/interface regulation for LaNiO 3 /Fe 2 O 3 core-shell catalysts during re-quenching in Co(NO 3 ) 2 solution, including richer lattice distortion and defects, and more heteroatom doping. The derived three-phase heterostructured catalysts exhibit significantly improved oxygen electrocatalytic activity with lattice oxygen participation, and the assembled liquid zinc–air batteries show excellent output power density and cycling performance. Our finding provides important insights into the synthesis of three-phase heterostructured catalysts and the regulation of heterogeneous interfaces through quenching engineering.}, archive = {J_ANGEW}, author = {Changchun Ye and Zhipeng Yu and Jin Yang and Junpeng Xie and Yangze Huang and JieChang Gao and Gui Xu and Jiantie Xu and Zhenghui Pan and Yajie Liu and Lifeng Liu and Xin Wang and Zhixin Tai}, doi = {10.1002/anie.202422451}, journal = {Angewandte Chemie International Edition}, month = {8}, number = {32}, pages = {e202422451}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quenching-induced three-phase heterostructured catalysts for oxygen electrocatalysis with lattice oxygen participation}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Ortho-C─H alkylation of aryl chlorides by a catellani strategy. ANGEW, 64(31), e202583102. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583102}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202583102}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Ortho-C─H alkylation of aryl chlorides by a catellani strategy}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Unexpected activities of CYP152 peroxygenases toward non-carboxylic substrates reveal novel substrate recognition mechanism and catalytic versatility. ANGEW, 64(31), e202583101. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583101}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202583101}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Unexpected activities of CYP152 peroxygenases toward non-carboxylic substrates reveal novel substrate recognition mechanism and catalytic versatility}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Late-stage C─N bond cleavage enables diversification of multiple resonance materials (Angew. chem. int. ed. 31/2025). ANGEW, 64(31), e202514525. (www)

  @article{ , archive = {J_ANGEW}, author = {Masashi Mamada and Masaru Horiuchi and Jiping Hao and Nanami Matsuno and Kojiro Tanaka and Kenkera Rayappa Naveen and Masahiro Hayakawa and Junki Ochi and Susumu Oda and Yasuhiro Kondo and Takuji Hatakeyama}, doi = {10.1002/anie.202514525}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202514525}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Late-stage C─N bond cleavage enables diversification of multiple resonance materials (Angew. chem. int. ed. 31/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Splicing them together: Construction of Polyoxovanadate–Organic polyhedra-based pyrgoscages and catenanes (Angew. chem. int. ed. 31/2025). ANGEW, 64(31), e202513800. (www)

  @article{ , archive = {J_ANGEW}, author = {Ke-Wei Tong and Yan-Hu Wang and Jing Du and Chao-Qin Chen and Ya-Qian Lan and Peng Yang}, doi = {10.1002/anie.202513800}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202513800}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Splicing them together: Construction of Polyoxovanadate–Organic polyhedra-based pyrgoscages and catenanes (Angew. chem. int. ed. 31/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Blue-to-green fine-tunable narrowband delayed fluorescence in peripherally dendritic modified bis-indolocarbazoles (Angew. chem. int. ed. 31/2025). ANGEW, 64(31), e202513688. (www)

  @article{ , archive = {J_ANGEW}, author = {Jun Hyeon Lee and Takumi Watanabe and Lars Hartmanna and Takuma Yasuda}, doi = {10.1002/anie.202513688}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202513688}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Blue-to-green fine-tunable narrowband delayed fluorescence in peripherally dendritic modified bis-indolocarbazoles (Angew. chem. int. ed. 31/2025)}, volume = {64}, year = {2025}, }
• (2025). Ming zhao. ANGEW, 64(31), e202513012. (www)

  @article{ , archive = {J_ANGEW}, author = {Ming Zhao}, doi = {10.1002/anie.202513012}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202513012}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ming zhao}, volume = {64}, year = {2025}, }
• (2025). Jing wei. ANGEW, 64(31), e202512750. (www)

  @article{ , archive = {J_ANGEW}, author = {Jing Wei}, doi = {10.1002/anie.202512750}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202512750}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Jing wei}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: High-performance FeP catalyst for electrochemical ammonia production and recovery via joule-stripping (Angew. chem. int. ed. 31/2025). ANGEW, 64(31), e202512275. (www)

  @article{ , archive = {J_ANGEW}, author = {Yuan-Zi Xu and Robin N. Dürr and Florian Häfliger and Daniel F. Abbott and Victor Mougel}, doi = {10.1002/anie.202512275}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202512275}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: High-performance FeP catalyst for electrochemical ammonia production and recovery via joule-stripping (Angew. chem. int. ed. 31/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Photoinduced deoxygenative borylations of aliphatic alcohols”. ANGEW, 64(31), e202510750. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202510750}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202510750}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Photoinduced deoxygenative borylations of aliphatic alcohols”}, volume = {64}, year = {2025}, }
• (2025). Reversible trace-water-buffering frameworks for efficient humid methane purification. ANGEW, 64(31), e202510669. (www)

  @article{ , abstract = {Trace water is usually fatal to gas separation process because the adsorption sites of adsorbents can be readily devitalized under humid conditions. Here, we develop trace-water-buffering porous materials with reversible structural transformation triggered by water adsorption/desorption, achieving exceptional methane purification under humid conditions. Despite the different structures, both the hydrated and dehydrated materials show high adsorption capacities for bulky C 3 H 8 and intermediate-sized C 2 H 6 molecules but low CH 4 uptake. Based on these unique properties, the dehydrated material achieves efficient separation of ternary CH 4 /C 2 H 6 /C 3 H 8 mixtures even under 100% relative humidity, delivering high-purity CH 4 (>99.99%) with a remarkable yield of 7.2 mmol·g −1 . This work sheds light on the designed synthesis of a new generation of microporous materials with reversible water-buffering performance for gas purification under practically humid conditions.}, archive = {J_ANGEW}, author = {Cheng Chen and Ming Li and Shuixiang Zou and Wei Wei and Maochun Hong and Mingyan Wu}, doi = {10.1002/anie.202510669}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202510669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversible trace-water-buffering frameworks for efficient humid methane purification}, volume = {64}, year = {2025}, }
• (2025). Large N-doped zigzag hydrocarbon belts from calixarenes: Synthesis, structure, and properties. ANGEW, 64(31), e202509916. (www)

  @article{ , abstract = {Zigzag hydrocarbon belts and heteroatom-doped analogs have captivated chemists because of their unique structures, tantalizing properties, and potential applications. Despite synthetic breakthroughs, the diversity, especially, the size of belts synthesized by fjord-stitching approach is limited by resorcin[n]arenes ( n = 4, 6). We report herein the synthesis, structure and properties of large belts starting from conventional calix[8]arenes. The synthesis features multiple C─N cross-coupling reactions of per-brominated calix[8]arenes with anilines and ammonia, and selective transformation of 1,4-dihydroquinoline into quinolin-4(1 H )-one segments. The molecules in question adopt a unique zigzag belt structure with nitrogen atoms and functional groups located around both portals, yielding a large octagonal prism cavity. They are able to accommodate fullerene C 60 or C 70 with high affinity driven by lone-pair electron/π interactions and steric complementarity between host and guest.}, archive = {J_ANGEW}, author = {Yi Peng and Mei-Ling Tan and Ke-Xing Ma and Shuo Tong and Mei-Xiang Wang}, doi = {10.1002/anie.202509916}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Large N-doped zigzag hydrocarbon belts from calixarenes: Synthesis, structure, and properties}, volume = {64}, year = {2025}, }
• (2025). Guest polarizability directed molecular “Freezing” within non-metal porous salt frameworks. ANGEW, 64(31), e202509905. (www)

  @article{ , abstract = {Isoreticular non-metal salt frameworks with permanent porosity have emerged recently as a fantastic platform for molecular separation, but the underlying guest-framework interactions within their charge-separated ionic channels remain to be explored. Here, we report the first case of guest polarizability-directed molecular “freezing” of noble gas occurring within a non-metal porous organic ammonium framework, which bears well-organized, high-density chloride anions as nodes. Notably, the framework exhibits a distinctive, thermally-independent commensurate adsorption toward highly polarizable Xe, while traditional thermodynamic adsorption behaviors are observed for Kr with lower polarizability. A remarkable Xe adsorption capacity of 1.47 mmol g −1 and a record-high separation factor of 10.2 are thus achieved in dynamic Xe/Kr separation under ambient conditions. The practical potential for realistic Xe/Kr separation from the off-gas of used nuclear fuel (UNF) reprocessing is demonstrated. Theoretical calculations identify the presence of multiple strong Xe⋯Cl interactions as the driving force within the size-matching ionic channels of the salt framework.}, archive = {J_ANGEW}, author = {Yi Xie and Qiang Gao and Jianchen Wang and Gang Ye and Banglin Chen}, doi = {10.1002/anie.202509905}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509905}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Guest polarizability directed molecular “Freezing” within non-metal porous salt frameworks}, volume = {64}, year = {2025}, }
• (2025). Titanium-catalyzed C─X and C─H borylation of aryl halides for the synthesis of bis(boronate)benzenes. ANGEW, 64(31), e202509778. (www)

  @article{ , abstract = {Despite the intensive studies on the synthesis and application of aryl boronates, most focus on mono-borylated arenes. The multi-borylated arenes, on the other hand, have received much less attention because the preparation of multi-borylated arenes in a straightforward manner is still underdeveloped. Herein, we present our findings on synthesizing bis-borylated arenes from structure-diverse and readily available aryl halides (Ar─X, X = Cl, Br, I). Simultaneous C─X and C─H borylation of aryl halides is achieved using earth-abundant titanium as a catalyst. Not only the 1,2-bis borylation but also the 1,3- and 1,4-bis borylation are achieved. Control experiments and density functional theory (DFT) computations propose a titanium-mediated aryl radical-driven reaction resulting in selective bis-borylation over mono-borylation.}, archive = {J_ANGEW}, author = {Xiaoxian Li and Ximei Tian and Haijun Jiao and Lipeng Wu}, doi = {10.1002/anie.202509778}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509778}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Titanium-catalyzed C─X and C─H borylation of aryl halides for the synthesis of bis(boronate)benzenes}, volume = {64}, year = {2025}, }
• (2025). Interfacial engineering and structural modulation of RuO2-based catalysts for highly active and durable oxygen evolution reaction in acidic environment. ANGEW, 64(31), e202509768. (www)

  @article{ , abstract = {Developing highly active and durable catalysts for the oxygen evolution reaction (OER) under acidic conditions is key to commercializing green hydrogen production via water splitting. Here, we fabricated a cobalt oxide (Co 3 O 4 )-synergized nickel-doped ruthenium oxide (Ni-RuO 2 ) heterojunction on reduced graphene oxide (Co 3 O 4 /Ni-RuO 2 /rGO) as an efficient and durable OER electrocatalyst in acidic electrolytes. The interface of Co 3 O 4 /Ni-RuO 2 heterojunction and doping of Ni into RuO 2 , as well as their effect on electronic structure, were examined by advanced characterizations. With only 1.36 wt% RuO 2 , the Co 3 O 4 /Ni-RuO 2 /rGO heterojunction revealed an ultra-low overpotential of 195 and 305 mV at 10 and 100 mA cm −2 , respectively. Moreover, the catalyst's performance was well maintained after operating for 100 h at 500 mA cm −2 , suggesting great promise for practical applications. Density functional theory calculations and in situ Raman analysis indicate that both the heterojunction structure and Ni doping play crucial roles in enhancing the OER activity and durability. This study provides a promising avenue for developing cost-effective electrocatalysts with superior activity and stability for advanced energy conversion.}, archive = {J_ANGEW}, author = {Weiwei Yang and Zhijun Wang and Jie Zhang and Liangyong Jia and Jiahui Li and Xinyu Chen and Xinyang Liu and Huayang Zhang and Jingkai Lin and Ming Zhao and Qingjun Chen}, doi = {10.1002/anie.202509768}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509768}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial engineering and structural modulation of RuO2-based catalysts for highly active and durable oxygen evolution reaction in acidic environment}, volume = {64}, year = {2025}, }
• (2025). Nucleation and growth mechanisms of Micro/Nano structural manganese-trimesic acid coordinations for aqueous zinc-ion batteries. ANGEW, 64(31), e202509741. (www)

  @article{ , abstract = {Nucleation and growth of metal–organic frameworks (MOFs) are critical for controlling their morphology, size, and performance. Guided by the crystal nucleation and growth theory, this study systematically explored the effects of the sequential addition of ligand trimesic acid (BTC) and manganese ions (Mn 2+ ), ligand-to-metal ion ratio, solvent composition, and surfactants on the nucleation and growth of MnBTC. The regulatory mechanisms of the crystal morphology and internal structure were deeply revealed. Moreover, the established machine learning (ML) model can accurately predict the concentrations of ─COO − and Mn 2+ , providing important guidance for the controlled synthesis of MOFs in the future. In practical, the electrochemical performance of MnBTC with different morphologies and sizes was evaluated for aqueous zinc-ion batteries. The reaction mechanism of MnBTC during the charge–discharge process was investigated through a series of in situ and ex situ characterizations, and MnBTC demonstrated excellent energy-storage performance. This study opens a new window for the precise synthesis of MOFs, which show strongly controlled micro/nano structure and coordination environment based on the crystal nucleation and growth theory with the assistance of ML.}, archive = {J_ANGEW}, author = {Qian Li and Yanfei Zhang and Xiaotian Guo and Zhangbin Yang and Yixuan Wang and Yumeng Chen and Yiwen Liu and Haotian Yue and Shengjie Gao and Huijie Zhou and Jianfei Huang and Mohsen Shakouri and Yonggang Wang and Guoyin Zhu and Zheng Liu and Yizhou Zhang and Huan Pang}, doi = {10.1002/anie.202509741}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509741}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nucleation and growth mechanisms of Micro/Nano structural manganese-trimesic acid coordinations for aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed Suzuki–Miyaura cross-coupling reaction of aliphatic alcohol derivatives. ANGEW, 64(31), e202509657. (www)

  @article{ , abstract = {Reactions leveraging readily available starting materials are valuable for synthetic utility, especially for late-stage functionalization. Herein, we report a nickel-catalyzed Suzuki–Miyaura cross-coupling (XC) reaction of aliphatic sulfonates with aryl boronic acids. This reaction provides straightforward access to an array of arylated products in good yield. We have established a one-pot protocol allowing for the arylation of alcohols in a single reaction vessel. Additionally, an asymmetric reaction was developed to provide enantioenriched α-aryl and heteroaryl glutarimides in good yield and enantioselectivity.}, archive = {J_ANGEW}, author = {Chloe D. Wong and Lauren C. Bradford and Nadia Hirbawi and Elizabeth R. Jarvo}, doi = {10.1002/anie.202509657}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509657}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed Suzuki–Miyaura cross-coupling reaction of aliphatic alcohol derivatives}, volume = {64}, year = {2025}, }
• (2025). Late-stage C─N bond cleavage enables diversification of multiple resonance materials. ANGEW, 64(31), e202509606. (www)

  @article{ , abstract = {Recent advances in materials development for organic light-emitting diodes (OLEDs) have been driven by an emerging design concept known as multiple-resonance (MR), which provides the benefits of high efficiency and color purity required for commercial OLED displays. Borylation reaction constructing MR frameworks is a key step for developing new π-conjugated systems, while this reaction includes the limitation of selectivity, making it challenging to control reactions in elaborate molecular structures. Although a wide variety of MR compounds have been prepared through carefully planned synthetic schemes based on retrosynthetic analysis, these tasks typically require significant effort for each individual target. Herein, we demonstrate a successful late-stage functionalization strategy that enables structural modifications after the borylation reaction, especially in hardly accessible regions in MR structures via carbon–nitrogen bond cleavage. Our new synthetic method also allows access to new products which were never feasible before. The newly developed material, DABNA-dimer , proves the impact of late-stage functionalization on OLED characteristics. The present study serves as a proof-of-concept for a diversity-orientated synthesis in the development of MR materials.}, archive = {J_ANGEW}, author = {Masashi Mamada and Masaru Horiuchi and Jiping Hao and Nanami Matsuno and Kojiro Tanaka and Kenkera Rayappa Naveen and Masahiro Hayakawa and Junki Ochi and Susumu Oda and Yasuhiro Kondo and Takuji Hatakeyama}, doi = {10.1002/anie.202509606}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509606}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Late-stage C─N bond cleavage enables diversification of multiple resonance materials}, volume = {64}, year = {2025}, }
• (2025). Anomalous piezochromic luminescence in covalent triazine frameworks via molecular insertion: Blueshifted and enhanced emission. ANGEW, 64(31), e202509398. (www)

  @article{ , abstract = {Piezochromic materials typically exhibit pressure-induced redshifted and quenched emission due to enhanced intermolecular π–π stacking and molecular planarization. Consequently, achieving blueshifted and enhanced emission in π-conjugated systems remains a significant challenge. Here, we report anomalous piezochromic luminescence in covalent triazine frameworks (CTFs) via molecular insertion. Upon introducing methanol into the nanopores of CTFs, a blueshift in emission from 507.0 to 485.5 nm, accompanied by enhanced intensity, is observed under compression up to 1.22 GPa, distinctly contrasting the redshifted and quenched emission typically observed in compressed pristine CTFs and other crystalline porous materials (CPMs). Combined experimental and theoretical analyses reveal that methanol can weaken the interlayer π–π stacking and intralayer conjugation of CTFs by forming weak interactions with CTFs, such as hydrogen bonding, to realize the interlayer slip and intralayer distortions of CTFs, which results in the blueshifted and enhanced emission. This strategy also proves effective with other molecular insertions, offering a general approach to achieving anomalous piezochromic luminescence in CTFs. Our findings establish molecular insertion as a robust method for engineering pressure-responsive luminescent materials and provide valuable insights for the design of advanced optical sensors and stimuli-responsive systems.}, archive = {J_ANGEW}, author = {Zhenxing Yang and Chunguang Zhai and Lingyan Dang and Zhenfeng Niu and Yuchen Shang and Xinmeng Hu and Yaqi Wang and Tianzi Zhou and Mingguang Yao}, doi = {10.1002/anie.202509398}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509398}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anomalous piezochromic luminescence in covalent triazine frameworks via molecular insertion: Blueshifted and enhanced emission}, volume = {64}, year = {2025}, }
• (2025). Correction to “Vertically expanded covalent organic frameworks for photocatalytic water oxidation into oxygen”. ANGEW, 64(31), e202509350. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202509350}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Vertically expanded covalent organic frameworks for photocatalytic water oxidation into oxygen”}, volume = {64}, year = {2025}, }
• (2025). Deciphering the N─N coupling mechanism over Iron–Copper alloy catalysts during ammonia decomposition. ANGEW, 64(31), e202509322. (www)

  @article{ , abstract = {The production of CO x -free hydrogen via the ammonia decomposition reaction (ADR) using Fe-based non-precious metal catalysts has attracted much attention. N─H bond cleavage and N─N coupling are two key steps in ADR, however, stronger Fe─N binding leads to lower activity of iron catalysts. Herein, we develop FeCu alloy catalysts with optimized metal-nitrogen binding energy by incorporating Cu, a metal with inherently weaker nitrogen affinity, into Fe-based catalysts. The optimized Fe 1 Cu 0.5 /MgO catalyst exhibits remarkable catalytic performance, achieving an impressive H 2 production rate of 139.1 mmol H 2 g cat −1 h −1 at 550 °C under a high gas hourly space velocity (GHSV = 360 000 h −1 ). Mechanistic studies reveal that the modulation of the d -band structure due to the alloying effect optimizes the dissociation of NH 3 and the binding ability of N* intermediates in the ADR process. Notably, in situ X-ray absorption spectroscopy (XAS) combined with theoretical calculations confirm that FeCu alloying effectively reduces the N─N recombination energy barrier from 2.25 eV (Fe cluster) to 1.77 eV (FeCu cluster). These findings provide valuable insights for the rational design of highly active Fe-based catalysts for efficient ammonia decomposition and sustainable hydrogen production.}, archive = {J_ANGEW}, author = {Xun Qi and Yu Zhang and Cai Chen and Jiarui Yang and Jie Wen and Zechao Zhuang and Zhicheng Zhang and Dingsheng Wang and Hui Zhang}, doi = {10.1002/anie.202509322}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509322}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering the N─N coupling mechanism over Iron–Copper alloy catalysts during ammonia decomposition}, volume = {64}, year = {2025}, }
• (2025). Ortho-C─H alkylation of aryl chlorides by a catellani strategy. ANGEW, 64(31), e202509300. (www)

  @article{ , abstract = {Herein we report a general and practical palladium/norbornene catalysis system that effectively promotes difunctionalization of less reactive aryl chlorides. The key to success lies in the use of a particular norbornene (NBE) derivative as a powerful mediator that synergistically cooperates with the palladium catalyst and an electron-rich phosphine ligand. A broad spectrum of electronically diverse aryl chlorides (57 examples) delivered the corresponding ortho -C─H alkylation/ ipso -olefination products in moderate to good yields. Notably, this protocol features excellent functional-group tolerance, high concentration, scalability, and late-stage functionalization of complex aryl chlorides. Furthermore, by integrating this chemistry with its counterparts involving aryl iodides and bromides, an intriguing triple-Catellani reaction sequence was developed, rapidly increasing molecular complexity and diversity. Finally, DFT calculations were performed, revealing that noncovalent C─H⋯O interactions between the XPhos ligand and the NBE mediator promote the pivotal NBE insertion step.}, archive = {J_ANGEW}, author = {Jian-Shu Wang and Zequan Liu and Guangyin Qian and Xiahe Chen and Liming Cao and Tiaozhen Yu and Jinxiang Ye and Yuanyuan Ma and Shuqing Chen and Zuo Yang and Hong-Gang Cheng and Yun-Fang Yang and Qianghui Zhou}, doi = {10.1002/anie.202509300}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509300}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ortho-C─H alkylation of aryl chlorides by a catellani strategy}, volume = {64}, year = {2025}, }
• (2025). Decoupling the SHG-birefringence trade-off in UV NLO materials via triple-control coordination engineering: Achieving synergistic performance optimization. ANGEW, 64(31), e202509290. (www)

  @article{ , abstract = {Decoupling the trade-off between second-harmonic generation (SHG) and birefringence ( Δn ) while maintaining a wide bandgap ( E g ) is a critical challenge in the field of ultraviolet (UV) nonlinear optical (NLO) materials. In this work, we introduce a novel “triple-control coordination engineering” strategy that successfully addresses this challenge. By integrating dihedral angle modulation, coordination mode switching, and polarizability engineering, we have synthesized three zinc halides—[(C 5 H 6 N 2 O 2 )(C 5 H 5 N 2 O 2 )ZnCl ( I ), (C 5 H 6 N 2 O 2 )ZnCl 2 ( II ), and (C 5 H 6 N 2 O 2 )ZnBr 2 ( III )]—that exhibit exceptional UV NLO performance. Through dynamic C─C─N bond rotation, we achieved precise control over the dihedral angle (81°→84°), effectively modulating optical anisotropy (Δn = 0.048–0.071@1064 nm). pH/temperature-driven coordination mode evolution enabled complete alignment of the [ZnO 2 X 2 ] polyhedron, while halogen substitution (Cl → Br) amplified polarizability gradients. These advancements resulted in a stepwise amplified SHG response (0.4→3.5→8.2 × KH 2 PO 4 , abbreviated as KDP), controlled Δn , wide E g (>5.0 eV), and remarkable thermal stability (>250 °C). Notably, (C 5 H 6 N 2 O 2 )ZnBr 2 stands out as the first zinc-based halide to simultaneously achieve large SHG (>8 × KDP), moderate birefringence (0.05< Δn < 0.1), and a wide bandgap ( E g > 5.0 eV). This work not only provides a paradigm-shifting approach to materials design but also paves the way for the development of UV NLO materials with superior comprehensive performance.}, archive = {J_ANGEW}, author = {Yaolong Zhu and Jie Gou and Can Yang and Qingwen Zhu and Yi Xiong and Qi Wu}, doi = {10.1002/anie.202509290}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509290}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoupling the SHG-birefringence trade-off in UV NLO materials via triple-control coordination engineering: Achieving synergistic performance optimization}, volume = {64}, year = {2025}, }
• (2025). Synergistic rigidity-enhancement and electron-rich systems engineering robust carbon dots-based ultra-narrowband NIR emitters for LEDs with superior operational stability. ANGEW, 64(31), e202509276. (www)

  @article{ , abstract = {Herein, we report the controllable synthesis of carbon dots (CDs) with high color purity, narrow full width at half maxima (FWHM) of 29, 32 and 39 nm, and near-infrared emission at wavelengths of 683, 695 and 704 nm. Structural characterization, transient absorption, temperature-dependent dynamics combined with theoretical calculations were investigated to elucidate the narrowband mechanism. Our results demonstrate that the high symmetry and substantial conjugation of the graphitic core enhance material rigidity with minimal exciton-capturing defects. The high pyrrole N content increases conjugated electron delocalization, promoting radiative recombination of confined electrons and holes, thereby reducing FWHM. The large exciton binding energy, weak electron-phonon coupling and simple radiative dynamics of the CDs further contribute to their ultra-narrow emission bandwidths. The CDs exhibit exceptional photo and thermal stabilities in extremely acidic or alkaline conditions and various organic solvents. No quenching or peak broadening is observed at high CD concentrations, rendering these materials suitable for applications in high-performance optoelectronic devices. Excitingly, CD-based light-emitting diodes (LEDs) can operate stably at a maximum current of 2000 mA and retain more than 94% of its performance for 150 h at 300 mA. LEDs utilizing these narrowband CDs provide high-color purity displays and specific steady-state lighting applications.}, archive = {J_ANGEW}, author = {Lin Ai and Jiping Xiao and Jingkun Yu and Kening Liu and Feifei Zhai and Wenjuan Xiang and Siyu Lu}, doi = {10.1002/anie.202509276}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509276}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic rigidity-enhancement and electron-rich systems engineering robust carbon dots-based ultra-narrowband NIR emitters for LEDs with superior operational stability}, volume = {64}, year = {2025}, }
• (2025). Thermally triggered redox flexibility of Pt/CeO2 cluster catalyst against in-situ atomic redispersion. ANGEW, 64(31), e202509239. (www)

  @article{ , abstract = {For supported catalysts, the redispersion of aggregated metal sites into single atoms is dictated by the reactant-induced metal-support interaction, which may also deteriorate the intrinsic activity. Here we discovered the spontaneous redispersion of CeO 2 -supported Pt clusters into Pt single atoms during catalytic CO oxidation, driven by Pt-CeO 2 interaction with surface hydroxyls as the key stabilizer. This structural evolution was accompanied by deactivation, leading to inferior catalytic activity. After achieving the clear distinction of PtO x clusters and Pt single atoms, we propose a thermal aging strategy to preserve the Pt clusters against redispersion. The high-temperature calcination at 800 °C significantly removed the surface hydroxyls of Pt/CeO 2 , thereby eliminating the anchoring sites for Pt redispersion and consequently preserving the Pt clusters. Moreover, the Ce 3+ /Ce 4+ redox cycles were triggered, enabling the interfacial Ce 3+ sites to fulfill O 2 activation. Together with the enhanced CO adsorption on Pt clusters over single atoms, this redox flexibility in valence change delivered superior activity for CO oxidation.}, archive = {J_ANGEW}, author = {Haofan Lei and Ningqiang Zhang and Sunpei Hu and Fenglin Peng and Jiahai Zhou and Jian He and Lijun Zhang and Haiqian Wang and Chao Ma and Han Yan and Ken-ichi Shimizu and Jie Zeng}, doi = {10.1002/anie.202509239}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509239}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermally triggered redox flexibility of Pt/CeO2 cluster catalyst against in-situ atomic redispersion}, volume = {64}, year = {2025}, }
• (2025). Reverse the impact of le chatelier's principle in two-electron air electroreduction. ANGEW, 64(31), e202509147. (www)

  @article{ , abstract = {Using high-purity oxygen (O 2 ) for electrofixation would increase the production cost of hydrogen peroxide (H 2 O 2 ) because of requiring complex pre-treatment procedures. Atmospheric air is an abundant source, but the direct air electrofixation has proved to be very challenging, that in common conception against nitrogen (N 2 ) in the system. According to the Le Chatelier's principle, O 2 concentration is diluted by N 2 (78%) in atmospheric air, which reduces overall reaction rates/equilibrium. Here we report a catalyst system where the presence of N 2 does not impose an adverse effect; rather, it is beneficial for activity. We combine both theoretical and experimental analyses to elucidate the underlying mechanisms, unlocking the critical function of electronic spin, arising from the strong synergy between iron oxide (FeO x ) and nickel-metal organic frameworks (Ni-MOF) that optimizes the activation of O 2 in air. Consequently, the catalyst for direct air electrofixation has demonstrated an exceptional H 2 O 2 yield rate (262.6 mg h −1 cm −2 ) and Faradaic efficiency (95.61%), outperforming its high-purity O 2 counterpart (184.32 mg h −1 cm −2 and 67.06%). We expect the present findings providing an additional dimension to leverage systems beyond the constraint of traditional rules.}, archive = {J_ANGEW}, author = {Lili Jiang and Zhihao Nie and Yuntong Sun and Minmin Yan and Baokai Xia and Jingjing Duan and Bingbao Mei and Sheng Chen}, doi = {10.1002/anie.202509147}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reverse the impact of le chatelier's principle in two-electron air electroreduction}, volume = {64}, year = {2025}, }
• (2025). Fully conjugated sp2 carbon-linked covalent organic frameworks enables accelerated exciton process for superior singlet oxygen photosynthesis for water remediation. ANGEW, 64(31), e202509141. (www)

  @article{ , abstract = {Photocatalytic oxygen (O 2 ) activation via energy transfer offers a sustainable approach for singlet oxygen ( 1 O 2 ) synthesis, while its performance suffers from the ultrafast exciton dissociation and sluggish intersystem crossing (ISC) process. Up to date, exciton regulation is still in its infancy. Here, via linkage engineering of covalent organic frameworks (COFs), we propose a fully conjugated sp 2 carbon-linked COFs (sp 2 c-Py-Bpy COFs) with strong exciton interaction and fast ISC for boosted 1 O 2 photosynthesis. The sp 2 c-Py-Bpy COFs delivers a record-high 1 O 2 yield (624 µM min −1 ) with 100% selectivity, which is ca. eight times that of the traditional imine-bridged COFs (Im-Py-Bpy COFs, ca. 95.8% selectivity), outperforming documented systems. Transient absorption spectroscopy and theoretical investigations demonstrate that the fully conjugated sp 2 carbon linkage of sp 2 c-Py-Bpy COFs can enhance Coulomb interaction, promote ISC and push forward the transfer of triplet exciton to the O 2 adsorption sites throughout the COFs matrix, jointly facilitating the energy transfer process for efficient 1 O 2 photosynthesis and bypassing the traditional electron transfer process. Hence, sp 2 c-Py-Bpy COFs can selectively degrade acetaminophen within minutes under visible light irradiation and enables stable degradation of emerging pollutants in a continuous flow membrane reactor (20 × 30 × 2 cm) utilizing natural sunlight and dissolved O 2 .}, archive = {J_ANGEW}, author = {Siyuan Guo and Kun Zhao and Luwen Liang and Zifan Li and Bin Han and Xinwen Ou and Shan Yao and Zhiqing Lin and Zhimin Dong and Yunhai Liu and Liqun Ye and Bo Weng and Yanpeng Cai and Zhifeng Yang}, doi = {10.1002/anie.202509141}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202509141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fully conjugated sp2 carbon-linked covalent organic frameworks enables accelerated exciton process for superior singlet oxygen photosynthesis for water remediation}, volume = {64}, year = {2025}, }
• (2025). Photoswitchable antimicrobial metallohelices. ANGEW, 64(31), e202508959. (www)

  @article{ , abstract = {Chiral subcomponent self-assembly is used to access optically pure, metallo-helical species based on Zn and Fe(II) and incorporating three transazobenzene units. UV–vis, circular dichroism, and NMR spectroscopies, alongside X-ray crystallographic and DFT computational studies are used to unambiguously characterize a highly reversible stepwise photochemical transformation to an all- cis state in which structural integrity and optical purity have been retained. Although the all- trans state of the water-soluble enantiomers exhibited low or moderate activity against Gram-positive strains, irradiation at 365 nm led to up to eight-fold reduction in MIC. Electron microscopy and a cell permeability assay indicate a membrane disruption mechanism; the higher activity of the photochemically-generated all- cis state is consistent with its more compact supramolecular fold.}, archive = {J_ANGEW}, author = {Changhao Liu and Mi Li and Xinyu Wang and Guoqing Li and Xue Zhao and Xuebin Wang and Siying Qin and Xuejian Zhang and Nicola J. Rogers and Xin Zhang and Qianshuo Dong and Guy J. Clarkson and Yuji Wang and Xinyi Yang and Peter Scott and Rubing Wang and Hualong Song}, doi = {10.1002/anie.202508959}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508959}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoswitchable antimicrobial metallohelices}, volume = {64}, year = {2025}, }
• (2025). Three-motif molecular junction covalent organic frameworks for symmetric all-organic lithium-ion battery. ANGEW, 64(31), e202508937. (www)

  @article{ , abstract = {The symmetric all-organic batteries (SAOBs) based on the same organic electrode materials for both cathode and anode are promising in achieving an efficient battery system with excellent electrode compatibility, compensable volume change, full discharge ability, low preparation cost, and simple operation procedure, etc. Herein, for the first time, we have designed a kind of anhydride-based three-motif molecular junction COFs (i.e., TAT-AZO-COF) through a melt polymerization method that can serve as dual-electrode active materials for SAOBs. The prepared TAT-AZO-COF with three-motif molecular junction units, resulting from the integration of a cathode-active carbonyl group, an anode-active azo group, and a changeably bipolar-active triazin group, could provide a tunable voltage inductive effect to simultaneously meet the requirements of SAOBs. Thus-assembled SAOBs display excellent rate performance, high energy density (125 Wh kg −1 ) at 1 A g −1 and superior long-cycle property (90 mAh g −1 over 10 000 cycles) at 10 A g −1 , which is represented to be the best high-current density performance among all the organic electrode materials in dual-electrode available SAOBs. The Li + storage mechanisms of three-motif molecular junction COFs are thoroughly scrutinized by experimental and theoretical identification, and the feasibility in practical application has been validated by a successfully assembled pouch cell.}, archive = {J_ANGEW}, author = {Wenhai Feng and Zhi Yang and Can Guo and Huifen Zhuang and Rui Xu and Haifu Zhang and Mingjin Shi and Zhengyang Chen and Yifa Chen and Ya-Qian Lan}, doi = {10.1002/anie.202508937}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508937}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three-motif molecular junction covalent organic frameworks for symmetric all-organic lithium-ion battery}, volume = {64}, year = {2025}, }
• (2025). Carboxylate-based electrolyte with bilateral functions enable working sodium-metal batteries at −60°C. ANGEW, 64(31), e202508584. (www)

  @article{ , abstract = {Sluggish interfacial reaction kinetics and unstable electrode/electrolyte interphases seriously hinder the practical applications of sodium-metal batteries (SMBs) with extremely low-temperature performance. Here, we propose an ester-based electrolyte featuring solvent-anion synergistic and self-purification functions that empowers SMBs to operate stably at record-low temperatures down to −60 °C. The weakly solvating fluorinated solvent (ethyl difluoroacetate, [EDFA]) constructs an anion-dominated solvated structure, where the high-donor-number trifluoroacetate anion (TFA − ) synergistically reduces the Na + desolvation energy barrier while triggering the defluorination of EDFA. This dynamic process in situ generates inorganic components (e.g., NaF) in the solid electrolyte interphase (SEI). Further, tris(trimethylsilyl) phosphite (TMSPi) additive effectively scavenges corrosive HF species through a self-purification mechanism, ensuring durable cathode-electrolyte interphase formation. As a result, the ester-based SMBs render a capacity retention of 96% at −40 °C (relative to the room-temperature capacity), exceptional rate capacity (81.64 mAh g −1 at 400 mA g −1 with 70.26% retention at −40 °C, which is the best rate capability at extremely low temperature compared to other ester-based SMBs), and extended cycle ability (>300 cycles at −40 °C and 100 cycles at −60 °C). This work establishes a new paradigm for developing ester-based electrolytes to address the extreme-temperature operation challenges of SMBs.}, archive = {J_ANGEW}, author = {Chao Hu and Ling Dai and Fei Huang and Yi Yang and Shuquan Liang and Guozhao Fang and Qiang Zhang}, doi = {10.1002/anie.202508584}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carboxylate-based electrolyte with bilateral functions enable working sodium-metal batteries at −60°C}, volume = {64}, year = {2025}, }
• (2025). Supramolecular structure enabled photo-responsive charge transport in porphyrin-based junctions. ANGEW, 64(31), e202508443. (www)

  @article{ , abstract = {Supramolecular electronics offers a valuable opportunity to fabricate functional devices with tunable charge transport (CT) behaviors. Their diverse and non-covalent structures allow for precise modulation of CT with external stimuli. Despite their potential, achieving effective CT modulation in supramolecules through external stimuli remains challenging due to a lack of rigid systems with a predictable response to such stimuli. To address this challenge, we explore the use of porphyrin-based supramolecular structures and their CT responses to light illumination. By incorporating rigid ligands to increase the spatial distance between two porphyrin units, we diminish their interactions, fabricating porphyrin-contained cages that exhibit a higher efficiency of electron-hole pair separation compared to the monomer in solid state. Leveraging this advantage, a more effective photo-responsive CT is achieved for cages in solid-state junctions compared to that of monomers. The current through cage junctions reduces upon illumination. Theoretical calculations indicate that the reduction in conductivity arises from an increased energy offset between the molecule and electrode under light irradiation. Moreover, the photo-responsive CT can be finely tuned by adjusting the metal ion coordinated within the porphyrin and the distance between the cage and the electrode. This research paves a new way for developing supramolecular optoelectronic devices.}, archive = {J_ANGEW}, author = {Ziang Zhang and Jie Tang and Yongkang Zhang and Pan Qi and Xinrui Zhang and Haohao Fu and Ming Wang and Cunlan Guo}, doi = {10.1002/anie.202508443}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508443}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular structure enabled photo-responsive charge transport in porphyrin-based junctions}, volume = {64}, year = {2025}, }
• (2025). Evidence for methylaluminoxane (MAO) molecular structure and reactivity from ultrahigh magnetic field 27Al MAS NMR spectroscopy combined with DFT calculations. ANGEW, 64(31), e202508409. (www)

  @article{ , abstract = {The structure and reactivity of methylaluminoxane (MAO), a reagent of major interest for olefin polymerization, both industrially and academically, has been probed using ultrahigh magnetic field solid-state NMR (28.2 T, 1200 MHz for 1 H Larmor frequency). High resolution methods combined with density functional calculations allowed for the identification and quantification of five major aluminum sites, providing precise information on the structure of MAO at the molecular level. Based on reactivity studies with THF and [ZrCp 2 Me 2 ], the main reactive centers are identified as bismethyl aluminum species stabilized via a bridging methyl group from a neighboring Al center, featuring both high chemical shift and quadrupolar coupling constants (162 ppm and 27.4 MHz, respectively). This approach demonstrates the ability to monitor the chemistry of MAO with unprecedented precision, enabling a state-of-the-art understanding of its structure and reactivity.}, archive = {J_ANGEW}, author = {Kai Szeto and Mostafa Taoufik and Franck Fayon and David Gajan and Eva Zurek and Jochen Autschbach and Julien Trébosc and Laurent Delevoye and Régis M. Gauvin}, doi = {10.1002/anie.202508409}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508409}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evidence for methylaluminoxane (MAO) molecular structure and reactivity from ultrahigh magnetic field 27Al MAS NMR spectroscopy combined with DFT calculations}, volume = {64}, year = {2025}, }
• (2025). Iridium-catalyzed enantioselective intramolecular hydroarylation of allenes: Formal synthesis of (+)-rhazinilam. ANGEW, 64(31), e202508252. (www)

  @article{ , abstract = {We report a versatile, highly enantioselective intramolecular hydroarylation of allenyl-tethered pyrroles and indoles. The reaction, promoted by an iridium(I)/bisphosphine chiral catalyst, provides a direct access heteropolycyclic systems bearing either tertiary or quaternary carbon stereocenters and a synthetically appealing alkenyl pendant. The method allows a highly efficient assembly of five-, six- and even seven-membered fused indole and pyrrole products, providing enantiomeric excesses of up to 99%. DFT computational studies align nicely with the experimental results and allow to rationalize the key factors that control both regio- and stereoselectivity of the process. Finally, the synthetic potential of the method was exemplified with a very short, highly enantioselective formal synthesis of (+)-Rhazinilam.}, archive = {J_ANGEW}, author = {Andrés Arribas and Alejandro Rey and Martín Calvelo and José L. Mascareñas and Fernando López}, doi = {10.1002/anie.202508252}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iridium-catalyzed enantioselective intramolecular hydroarylation of allenes: Formal synthesis of (+)-rhazinilam}, volume = {64}, year = {2025}, }
• (2025). Anomalous pH-dependence of ru for hydrogen electrochemistry. ANGEW, 64(31), e202508239. (www)

  @article{ , abstract = {The essence of the classic pH-dependent catalytic behavior of Pt toward hydrogen electrochemistry has been debated for decades. In stark contrast, Ru represents a unique exception by exhibiting intrinsically anomalous pH dependence among Pt-group metals, significantly challenging the universal validity of the existing mechanistic system derived from classic pH effects. To decode the chemical essence beneath the unique anomalous pH dependence, refined multidimensional structural characterizations and electrical transport spectroscopic studies reveal that the electron delocalization on Ru surface enables strong oxophilicity and unique pH-dependent coverage of OH*, essentially different from the H*-dominated Pt surface. The enriched OH* breaks the classic pH-dependent rule by forming hydrogen bond-regulated interfacial water structures, thus creating a unique chemical environment for alkaline hydrogen catalysis. By clearly decoding the anomalous pH-dependent behavior of Ru, our work provides new chances to improve the physicochemical model for re-understanding hydrogen electrochemistry.}, archive = {J_ANGEW}, author = {Yanyan Fang and Cong Wei and Tianshu Liu and Chongyang Tang and Zhaohui Liu and Xuanwei Yin and Bo Liu and Zhangyan Mu and Zenan Bian and Junxin Xiao and Peng Chi and Mengning Ding and Changzheng Wu and Gongming Wang}, doi = {10.1002/anie.202508239}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508239}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anomalous pH-dependence of ru for hydrogen electrochemistry}, volume = {64}, year = {2025}, }
• (2025). Multiply substituted (Hetero)acenes containing phosphonate group at the central unit as high-efficiency light emitters. ANGEW, 64(31), e202508168. (www)

  @article{ , abstract = {A new variant of the Friedel–Crafts–Bradsher (F-C-B) reaction offers access to dialkoxyphosphoryl substituted (hetero)acenes, especially to previously unavailable three- to seven-substituted, tri- and tetracyclic compounds, and features high chemical yields up to 95%, excellent photoluminescence (PL) quantum yields (QYs) up to 87.7%, large Stokes shifts up to 7943 cm −1 , and very mild, room temperature reaction conditions. The (RO) 2 P(O) has a distinct effect on the photophysical properties of acenes, increasing QYs by more than twofold compared to identical acenes not substituted by this group. DFT and TD-DFT calculations, combined with electron-hole analysis, indicated that local excitation (LE) had the dominant contribution to the electron excitation mechanism, and charge transfer (CT) of about 30% provided the highest fluorescence QYs. The multiple substitutions of (hetero)acenes bearing phosphonate moieties and electron-diverse substituents combined with a lower number of fused aromatic rings appear to be ideal for optimal chemical stability and high PL. The new, synthetic tool will accelerate exploitation of bulky (hetero)acene emitters for optoelectronic applications.}, archive = {J_ANGEW}, author = {Marek Koprowski and Łucja Knopik and Ewa Różycka-Sokołowska and Bogdan Dudziński and Vivek Vivek and Krzysztof Owsianik and Piotr Bałczewski}, doi = {10.1002/anie.202508168}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508168}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiply substituted (Hetero)acenes containing phosphonate group at the central unit as high-efficiency light emitters}, volume = {64}, year = {2025}, }
• (2025). Substrate preorganization within photoactive Pt12L24 nanospheres for accelerated decarboxylation catalysis at low concentrations. ANGEW, 64(31), e202508131. (www)

  @article{ , abstract = {Photoredox catalysis with short-excited state lifetimes or in dilute conditions is challenging because the photochemical mechanism relies on collisions within the excited state of the photocatalyst. In this work, we use supramolecular substrate preorganization within Pt 12 L 24 nanospheres as strategy to perform photoredox catalysis at low concentrations. We show that Pt 12 L 24 nanospheres are efficient photocatalysts for the decarboxylative oxygenation reaction. Nanospheres with endo-functionalized guanidinium groups (Pt 12 LGua 24 ) preorganize the substrate, which increases the catalytic turnover frequency by two orders of magnitude. Crucially, this preorganization ensures that Pt 12 LGua 24 retains its photocatalytic activity at extremely low concentrations (2 µM). This strategy thus overcomes the concentration limitations of photoredox catalysis and may be interesting for applications in dilute environments such as water purification and cellular photocatalysis.}, archive = {J_ANGEW}, author = {Rens Ham and Bettina Baumgartner and Joost N. H. Reek}, doi = {10.1002/anie.202508131}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508131}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Substrate preorganization within photoactive Pt12L24 nanospheres for accelerated decarboxylation catalysis at low concentrations}, volume = {64}, year = {2025}, }
• (2025). Uniform half-substituted chiral arylcycloparaphenylene: Synthesis, crystal structure, and chiroptical properties. ANGEW, 64(31), e202508017. (www)

  @article{ , abstract = {The strategic implementation of aryl-functionalization in every phenyl group in organic architectures presents a transformative approach to constructing novel molecular nanocarbon materials. In this present work, we demonstrate the first synthesis of a uniform and chiral half-aryl substituted cycloparaphenylene (CPP), [6]CPP-12 t BuPh . Single-crystal X-ray diffraction analysis unambiguously confirms its hoop-shaped structure and the existence of planar chirality arising from stereochemically distinct substituent orientations. The resolved pS and pR enantiomers display mirror-imaged circular dichroism (CD) signals and a high luminescence dissymmetry factor (| g lum | = 2.6 × 10⁻ 2 ). Photophysical characterization reveals the emergence of aggregation-induced emission (AIE) behavior, with pure [6]CPP-12 t BuPh powder sample exhibiting intense orange fluorescence.}, archive = {J_ANGEW}, author = {Wen Zhang and Jinyi Wang and Xinyu Zhang and Bing Yuan and Pengwei Fang and Nan Yin and Pingwu Du}, doi = {10.1002/anie.202508017}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508017}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Uniform half-substituted chiral arylcycloparaphenylene: Synthesis, crystal structure, and chiroptical properties}, volume = {64}, year = {2025}, }
• (2025). MOF coating enhances the ion tolerance of micromotors. ANGEW, 64(31), e202508001. (www)

  @article{ , abstract = {Electrophoretic-driven micro/nanomotors (EMNMs) offer great potential for biomedical applications due to their design flexibility. However, they face challenges in high-salt environments, where ionic quenching disrupts propulsion by collapsing the electrical double layer. This study introduces a versatile strategy by coating EMNMs with a MOF porous scaffold (ZIF-8), which acts as ion-conductive channels that replace the electrical Debye layers and support propulsion in high-salt solutions. Through a heteroepitaxial growth process, ZIF-8 was precisely coated on silicon micromotors, a typical model for EMNMs, significantly enhancing their ion tolerance. By optimizing both the MOF layer and the geometry factor, the micromotors achieved effective motion in PBS solution, comparable to blood salt levels, with their ion tolerance ( EI 50 ) improving by up to 266 times compared to uncoated micromotors. Additionally, the micromotors maintained stable, controllable motion under 980 nm NIR light, even when passing through an artificial blood vessel covered with biological tissues. In addition, the ZIF-8 coating offers drug-loading capabilities and pH-responsive release, along with biocompatibility, making these micromotors suitable for targeted drug delivery. This MOF coating strategy is versatile and scalable, and can be extended to other types of EMNMs, significantly enhancing their ion tolerance and unlocking new possibilities for biomedical applications.}, archive = {J_ANGEW}, author = {Leyan Ou and Kunfeng Liu and Yifan Zhang and Wanyuan Li and Zixian Liang and Dapeng Lei and Hao Sun and Mojun Chen and Jizhuang Wang and Jinyao Tang and Dan Li}, doi = {10.1002/anie.202508001}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202508001}, shortjournal = {Angew. Chem. Int. Edit.}, title = {MOF coating enhances the ion tolerance of micromotors}, volume = {64}, year = {2025}, }
• (2025). Activatable Fluorescence/Photoacoustic macromolecular probe for imaging of tumor-associated natural killer cells. ANGEW, 64(31), e202507765. (www)

  @article{ , abstract = {Detection of tumor-associated natural killer cells (TANKs) is crucial for evaluating cancer immunotherapy because they are found to be associated with improved overall survival rate. However, existing analytical methods relying on tissue biopsy are invasive and static, restricting their capacity to deliver dynamic information. Herein, we report an activatable near-infrared fluorescence (NIRF)/photoacoustic (PA) macromolecular reporter (BhCyNK) for real-time imaging of TANKs. To optimize the PA performance, the fluorophore scaffold of BhCyNK is screened. Among four hemicyanine derivatives, BhCy S with the longest absorption maximum (∼800 nm) as well as the highest photothermal conversion efficiency (71.13%) and PA brightness is constructed into BhCyNK, which specifically triggers its NIRF signal (by 10-fold increase) and PA signal (by 8.3-fold increase) in the presence of a TANK-overexpressed protease. BhCyNK effectively distinguishes natural killer cells from other immune cells including T cells, neutrophils, and macrophages. The high specificity of BhCyNK enables real-time monitoring of TANKs population in the tumor of living mice amid cancer immunotherapies. The imaging results reveal that the increasing intratumoral signal of BhCyNK after combination immunotherapy correlates well with the increasing population of TANKs. Thus, this study not only reports a molecular strategy to develop efficient PA fluorophores but also provides an ideal tool for noninvasive monitoring of immune cells.}, archive = {J_ANGEW}, author = {Yanbin Feng and Yuxuan Hu and Jing Liu and Xianghan Zhang and Yan Zhang and Zhongliang Wang and Kanyi Pu}, doi = {10.1002/anie.202507765}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507765}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activatable Fluorescence/Photoacoustic macromolecular probe for imaging of tumor-associated natural killer cells}, volume = {64}, year = {2025}, }
• (2025). A diazo linker ligand promotes flexibility and induced fit binding in a microporous copper coordination network. ANGEW, 64(31), e202507757. (www)

  @article{ , abstract = {Flexible organic linkers represent an intuitive and effective strategy to design flexible metal–organic materials. We report herein a systematic study concerning the effect of varying the central bond of mixed pyridyl-benzoate linkers, L, upon the flexibility of three isostructural kdd topology microporous coordination networks (CNs) of formula ML 2 : X-kdd-1-Cu , 1 = L = ( E )-4-(pyridin-4-yldiazenyl)benzoate; X-kdd-2-Cu , 2 = L = ( E )-4-(2-(pyridin-4-yl)vinyl)benzoate; the previously reported X-kdd-3-Cu , 3 = L = 4-(pyridin-4-ylethynyl)benzoate. As revealed by single crystal x-ray diffraction (SCXRD) and gas sorption studies, X-kdd-1-Cu , exhibited gate-opening during CO 2 and hydrocarbon (C2 and C8) sorption experiments whereas the other two CNs did not. Insight into these phase transformations was gained from in situ variable-pressure and variable temperature powder X-ray diffraction (PXRD), SCXRD, and modeling. Rotation of ligand 1 around the diazo bond, torsion angle changes between phenyl and carboxylate moieties, and deformation of the Cu-based rod building blocks enabled activated X-kdd-1-Cu to form new phases with C8 isomers and CH 2 Cl 2 , CH 2 Cl 2 inducing contraction of the activated phase. Computational studies suggest that 1 enables flexibility thanks to its lower barrier of deformation versus 2 or 3 . This study teaches that diazo moieties could offer a general strategy to enhance the flexibility of CNs.}, archive = {J_ANGEW}, author = {Xia Li and Debobroto Sensharma and Wells Graham and Volodymyr Bon and En Lin and Xiang-Jing Kong and Tao He and Andrey A. Bezrukov and Zhenjie Zhang and Stefan Kaskel and Timo Thonhauser and Michael J. Zaworotko}, doi = {10.1002/anie.202507757}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507757}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A diazo linker ligand promotes flexibility and induced fit binding in a microporous copper coordination network}, volume = {64}, year = {2025}, }
• (2025). Hetero-selective cross-linking of primary and secondary alkyl amines with CS2 under ambient aerobic oxidation for bioconjugation. ANGEW, 64(31), e202507734. (www)

  @article{ , abstract = {Umpolung of primary amines via isothiocyanation presents an attractive approach for cross-linking biorelevant molecules through two nucleophilic handles. However, conventional isothiocyanation reactions typically require highly electrophilic reagents or strongly oxidative conditions, rendering them unsuitable for complex molecular systems. Herein, we present a robust and nonchemist-friendly protocol for the isothiocyanation of primary alkyl amines using CS 2 under ambient aerobic oxidation conditions, eliminating the need for additional promoters. These mild conditions not only ensure broad compatibility with endogenous functional groups in biorelevant molecules but also unlock a powerful new capability: selective differentiation between primary and secondary alkyl amines. Notably, the unique suppression of homo-linking for both primary and secondary amines under these conditions enables near-perfect hetero-selectivity in cross-linking two different biorelevant molecules via their abundant amino handles in a one-pot operation, offering a streamlined, thiol-independent, and small-footprint approach to biocompatible conjugation.}, archive = {J_ANGEW}, author = {Shuai Jiang and Xin Chu and Xiangmei Kong and Xintao Miao and Xiaoxi Xu and Weimin Xuan and Chuanzheng Zhou and Gang He and Tianfei Liu and Gong Chen}, doi = {10.1002/anie.202507734}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507734}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hetero-selective cross-linking of primary and secondary alkyl amines with CS2 under ambient aerobic oxidation for bioconjugation}, volume = {64}, year = {2025}, }
• (2025). Unconventional PROTACs for targeted protein degradation in cancer therapy. ANGEW, 64(31), e202507702. (www)

  @article{ , abstract = {Targeted protein degradation, which aims to eliminate dysregulated proteins, has emerged as a promising strategy for conquering challenging therapeutic targets. Proteolysis-targeting chimera (PROTAC) is a heterobifunctional molecule that utilizes the ubiquitin-proteasome system to selectively degrade target proteins. Due to its ability to degrade “undruggable” proteins without causing drug resistance, PROTAC has shown great potential in innovative drug development, especially in cancer therapy. However, conventional PROTACs suffer from several limitations, such as limited solubility, poor permeability, hook effect, and off-target toxicity. Therefore, structural innovation of conventional PROTACs to make them meet the therapeutic demand is essential for unlocking the full potential of PROTACs as a therapeutic tool. Here, we summarize four types of unconventional PROTACs for addressing the above challenges and enhancing cancer therapy efficacy, including PROTACs with unconventional binding ligands, PROTACs with unconventional linkers, pro-PROTACs, and self-assembled PROTACs. These optimized designs contribute to the development of PROTACs-based universal platforms, providing directions for innovative drug developments and expanding the applications of PROTACs in cancer therapy.}, archive = {J_ANGEW}, author = {Xu Zhang and Zhangzhi Song and Xinyu Zhang and Jianhua Zou and Guocan Yu and Xiaoyuan Chen and Sheng Wang}, doi = {10.1002/anie.202507702}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unconventional PROTACs for targeted protein degradation in cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Identification of ti(salen) complexes for efficient catalysis in single-electron steps by cyclic voltammetry. ANGEW, 64(31), e202507673. (www)

  @article{ , abstract = {We describe the identification of an active Ti(salen) catalyst for the radical arylation of epoxides by a cyclic voltammetry study of mechanism-based predictors, such as the redox potentials of the complexes and their E q C r -equilibria, for the success of catalysis. Surprisingly, by far the most active catalyst features an uncommon tetrasubstituted ligand backbone, which renders chloride binding to the active Ti(III) species less favorable, thereby increasing catalyst activity due to improved substrate binding. Catalysis is most efficient in the “green” solvent ethyl acetate and can be initiated using base metals as well as electrochemical methods for the reduction of the Ti(salen)-precatalyst. Compared to the commonly employed titanocene catalysis, the use of the newly developed Ti(salen) catalyst allows for the use of milder and more sustainable reactions conditions, a broader substrate scope, and facile modification of the catalyst's electronic and steric properties.}, archive = {J_ANGEW}, author = {Niklas Schmickler and Sergei Gerber and Lennart Hanz and Stefan Grimme and Zheng-Wang Qu and Inke Siewert and Andreas Gansäuer}, doi = {10.1002/anie.202507673}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507673}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identification of ti(salen) complexes for efficient catalysis in single-electron steps by cyclic voltammetry}, volume = {64}, year = {2025}, }
• (2025). Framework integration for adaptive interfaces in flexible solid-state Lithium–Oxygen batteries. ANGEW, 64(31), e202507660. (www)

  @article{ , abstract = {Lithium–oxygen batteries (LOBs), with their remarkable energy density, represent a pivotal advancement in energy storage technology. However, conventional Li–O 2 batteries face significant obstacles. This study introduces polyacrylonitrile (PAN)-based polymer membranes and self-supporting cathodes fabricated via electrospinning and thermal treatment. By incorporating poly(diallyldimethylammonium chloride) (PDDA)-functionalized cathodes through electrostatic adsorption, a polymeric electrolyte-functional integrated linkage structure was developed. This design facilitates adaptive interface modulation, creating a stable low-impedance interface between the electrolyte and cathode while enabling efficient ion and electron transport. The resulting solid-state LOBs (SSLOBs) demonstrate exceptional performance, achieving a specific capacity of 8600 mAh g −1 and a cycling lifespan of 191 cycles. The adaptive interface provides abundant reaction sites, promoting uniform ring-like discharge product growth and reversible decomposition. Additionally, flexible batteries incorporating this structure exhibit outstanding resilience to bending deformation. These advancements highlight the transformative potential of Li–O 2 batteries, offering promising directions for future energy storage research.}, archive = {J_ANGEW}, author = {Jing Wu and Jiawei Shi and Zhenzhen Li and Minghui Li and Kecheng Pan and Yaying Dou and Yun Tian and Zhang Zhang and Zhen Zhou}, doi = {10.1002/anie.202507660}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507660}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Framework integration for adaptive interfaces in flexible solid-state Lithium–Oxygen batteries}, volume = {64}, year = {2025}, }
• (2025). Deuterating narrow-bandgap organic semiconductors for sensitive short-wave infrared photodetection. ANGEW, 64(31), e202507637. (www)

  @article{ , abstract = {Organic semiconductors exhibit significant potential for next-generation optoelectronic technologies owing to their structural tunability and solution processability; nevertheless, as their bandgap decreases, the nonradiative recombination for either exciton or photogenerated charge-carriers increases, limiting short-wave infrared (SWIR) photoresponse, as governed by energy gap law. Here, a deuteration strategy is employed to universally reduce the nonradiative decay pathways of SWIR organic semiconductors, enhancing photodetector sensitivity. Compared to protonated L4, the rational deuterated molecule (BT-12D) maintains SWIR photoresponse to ∼1.7 µm and exhibits lower stretching vibrational frequency (2350 cm −1 vs. 3063 cm −1 ), resulting in reduced recombination and 40% increase in specific detectivity ( D * ) at 1.3 µm for PDPPDTP: BT-12D-based organic photodetectors (OPDs). Likewise, deuterated L2-eC9-10D-based OPDs blending with PTB7-Th exhibit 14% higher D * (1.24 × 10 12 Jones at 1.2 µm) and faster rise/fall time (1.0/1.2 µs) than protonated devices (1.09 × 10 12 Jones; 1.6/1.7 µs). The optimized D * of deuterated OPDs is comparable to and even better than those of commercial detectors at 0.9–1.2 µm, while the corresponding response time is the fastest value reported for SWIR OPDs. These results highlight the broad applicability of deuteration as an effective strategy to suppress nonradiative decay pathways in SWIR organic semiconductors, unlocking new opportunities for sensitive SWIR optoelectronics.}, archive = {J_ANGEW}, author = {Zhenzhen Zhang and Yujie Yang and Tengfei Li and Huiqing Hou and Yifei Geng and Qianqian Lin and Yuze Lin}, doi = {10.1002/anie.202507637}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deuterating narrow-bandgap organic semiconductors for sensitive short-wave infrared photodetection}, volume = {64}, year = {2025}, }
• (2025). A thorough characterization of the tellurocyanate anion. ANGEW, 64(31), e202507543. (www)

  @article{ , abstract = {Tellurocyanate, [TeCN] − , is the heaviest group 16 congener of the cyanate anion, [OCN] − . Due to the relative instability of the C─Te bond, tellurocyanate chemistry has seen only scarce attention. Here, we present the facile synthesis and thorough characterization of [K@crypt-222][TeCN]. The anion is essentially linear with interatomic distances C─N = 1.150(6)Å and C─Te = 2.051(4)Å, thus approximating a C≡N triple bond and for C─Te a bond order between 1 and 2. Fully 13 C and 15 N labeled [Te 13 C 15 N] − allowed for the extraction of chemical shifts and all possible coupling constants ( 13 C = 77.8 ppm, 15 N = 285.7 ppm, 125 Te = −566 ppm, 1 J 13C-15N = 8 Hz, 1 J 13C-125Te = 748 Hz, 2 J 15N-125Te = 55 Hz), which were also determined independently by quantum chemical calculations. In the series [ Ch CN] − ( Ch = O─Te), [TeCN] − shows the strongest spin-orbit coupling (SOC) induced heavy-atom effect on the light-atom shielding (SO-HALA-effect). In contrast, 15 N shifts are also well described without considering relativistic effects and/or SOC. Negative-ion photoelectron spectroscopy was used to extract the electron affinity (EA = 3.034 eV) and spin-orbit splitting (3807 cm −1 ) of [TeCN] • . These values continue the trends of falling EA and rising SOC in the series [ Ch CN] • .}, archive = {J_ANGEW}, author = {Hennes Günther and Florian Weigend and Xiulan Xie and Wenjin Cao and Xiao-Fei Gao and Xue-Bin Wang and Frank Tambornino}, doi = {10.1002/anie.202507543}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507543}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A thorough characterization of the tellurocyanate anion}, volume = {64}, year = {2025}, }
• (2025). In-situ dynamic compensation strategy enables jahn-teller effect suppression in zn-doped dual-active-site copper hexacyanoferrate cathodes for high-energy and ultra-stable ammonium-ion storage. ANGEW, 64(31), e202507427. (www)

  @article{ , abstract = {Copper hexacyanoferrate (CuHCF) with 3D channels and high discharge plateau is widely recognized as a highly promising cathode material for ammonium-ion (NH 4 + ) storage. However, the practical application of CuHCF has faced challenges due to limited capacity and structural instability, primarily arising from single active site and serious Jahn–Teller distortions. Herein, an innovative in-situ dynamic compensation strategy is reported to prepare Zn-doping dual-active-site CuHCF (ZnCuHCF) as high-energy and ultrastable cathode materials for NH 4 + storage. Zn doping induces fission of Cu e 2g orbitals, causing lattice to aberrate and reach stable state, while during NH 4 + intercalation process, changes mainly in Fe t 2g electronic orbitals help maintain stability of ZnCuHCF structure. Consequently, ZnCuHCF in 23 m NH 4 OTf + 0.5 m Zn(OTf) 2 aqueous electrolyte exhibits high discharge potential of 0.94 V, high capacity of 121.7 mAh g −1 at 1 A g −1 and impressive capacity retention of 92.1% after 10 000 cycles. To highlight, fiber-shaped aqueous Zn/NH 4 hybrid batteries based on ZnCuHCF cathode are successfully constructed, achieving admirable energy density of 85.73 mWh g −1 and remarkable capacity retention of 85.2% after 12 500 cycles. This work paves the way for designing CuHCF with high capacity, high voltage and robust cycling stability in NH 4 + storage for applications in wearable aqueous batteries.}, archive = {J_ANGEW}, author = {Lijie Han and Ying Ling and Wenbin Gong and Dewei Xiao and Jie Luo and Qichong Zhang}, doi = {10.1002/anie.202507427}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507427}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-situ dynamic compensation strategy enables jahn-teller effect suppression in zn-doped dual-active-site copper hexacyanoferrate cathodes for high-energy and ultra-stable ammonium-ion storage}, volume = {64}, year = {2025}, }
• (2025). Sn catalysts with build-in [NCN]2− as proton relay for industrial-grade CO2 reduction at low overpotential. ANGEW, 64(31), e202507422. (www)

  @article{ , abstract = {Electrochemical CO 2 reduction (ECO 2 R) involves multiproton electron transfer, characterized by sluggish reaction kinetics and challenges including high overpotential and subsequently poor stability. Facilitating proton transfer through rational catalyst design to reduce the applied potential enables effective and durable CO 2 reduction. Herein, a proton migration promotion strategy to accelerate the CO 2 protonation and the overall ECO 2 R process was explored by Sn-based cyanamide catalysts. Catalysts with varying [NCN] 2− content, from SnO to Sn 2 ONCN and SnNCN, were investigated to elucidate the proton transfer mechanism of build-in [NCN] 2− . The reversible structural transformation between [N═C═N] 2− and [N≡C─N] 2− from [NCN] 2− group achieves an efficient proton relay effect. More efficient CO 2 conversion to HCOOH is achieved with a higher content of build-in [NCN] 2− groups in structures. Among these catalysts, SnNCN showed a current density of 450 mA cm −2 at a low overpotential of 360 mV, with a maximum Faradaic efficiency (FE) of 97.4% for HCOO − production and a peak cathodic energy conversion efficiency (ECE) of 79.6%. Furthermore, it produced formate (HCOO − ) continuously for over 110 h at 200 mA cm −2 and pure formic acid (HCOOH) solution for 192 h at 135.8 mA cm −2 . This study provides a novel material system and a fresh perspective for the design of efficient ECO 2 R catalysts.}, archive = {J_ANGEW}, author = {Kaili Zhu and Bingquan Jia and Zhe Chen and Zhuang Hu and Licheng Sun and Tao Wang and Biaobiao Zhang}, doi = {10.1002/anie.202507422}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507422}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sn catalysts with build-in [NCN]2− as proton relay for industrial-grade CO2 reduction at low overpotential}, volume = {64}, year = {2025}, }
• (2025). Unveiling nonadiabatic pathways in small molecule activation: Dinuclear uranium-mediated h2 and n2 bond cleavage. ANGEW, 64(31), e202507416. (www)

  @article{ , abstract = {Nonadiabatic effects have been extensively studied in photoexcited processes, but their role in thermal process so far has neither been thoroughly studied nor appreciated, despite their significance. In this work, H 2 and N 2 activation mediated by a diuranium complex was studied from a nonadiabatic perspective using multi–configurational ab initio calculations combined with density functional theory. Stepwise electron transfer during the reaction enhances degeneracy between electronic states, enabling state-to-state transitions, i.e., spin downshift. The dual functionality of transition states acting as thermodynamic gateways and channels for nonadiabatic transitions was disclosed. The π and σ cooperative activation explains the unprecedented reactivity by the diuranium cooperation. Bonding analysis reveals that U 5f/6d orbitals mixing with H 1s /N 2p orbitals afford some degree of covalency to the primarily ionic U─H/N interactions, with the 6d-orbitals contributing more pronounced than the 5f-orbitals in σ interactions, while the U─N π bonding exhibits significant U 5f contributions.}, archive = {J_ANGEW}, author = {Liangliang Wu and Xi-ai Zhang and Xiaoyan Cao and Wei-Hai Fang and Michael Dolg and Xuebo Chen}, doi = {10.1002/anie.202507416}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling nonadiabatic pathways in small molecule activation: Dinuclear uranium-mediated h2 and n2 bond cleavage}, volume = {64}, year = {2025}, }
• (2025). A cu-pb hybrid layer architecture as a new structural prototype for high-efficiency 2D double perovskite broadband emitters. ANGEW, 64(31), e202507375. (www)

  @article{ , abstract = {Two-dimensional (2D) organic lead halide perovskites have emerged as promising next-generation luminescent materials due to their high chemical versatility and excellent broadband light emission properties. However, their practical applications are often limited by low photoluminescence quantum yields (PLQYs) caused by insufficient exciton confinement and extended charge-carrier diffusion lengths within the 2D anionic layers. To overcome these limitations, we developed a novel multicomponent structural engineering strategy that led to the design of [AMP] 2 Cu 2 PbX 8 double perovskites [AMP = 4-(Aminomethyl)piperidinium, X═Br − and I − ]. These materials feature [Cu 2 PbX 8 ] 4− monolayers consisting of alternating corner-sharing [Cu 2 X 6 ] 4− dimers and [PbX 6 ] 4− octahedra. Compared to the negligible luminescence observed in 2D [AMP]PbX 4 analogs, the [AMP] 2 Cu 2 PbX 8 compounds demonstrate strong broadband yellow-orange emission originating from self-trapped excitons (STEs), achieving high PLQYs exceeding 48%. Comprehensive spectroscopic analysis and theoretical studies reveal that the incorporation of [Cu 2 X 6 ] 4− dimers simultaneously enhances exciton binding energy, electron/hole effective mass, exciton confinement efficiency and STE self-trapping depth, which are all critical factors contributing to the improved PLQY. This work successfully demonstrates a new class of 2D double perovskites with exceptional luminescent performance, advancing perovskite chemistry through a dual-engineering strategy that concurrently optimizes both material structure and photophysical properties.}, archive = {J_ANGEW}, author = {Jia-Peng Li and Dong-Yang Li and Yu Cheng and Jiawei Lin and Honghan Fei and Zhongliang Gong and Cheng-Yang Yue and Lingling Mao and Xiao-Wu Lei}, doi = {10.1002/anie.202507375}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507375}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A cu-pb hybrid layer architecture as a new structural prototype for high-efficiency 2D double perovskite broadband emitters}, volume = {64}, year = {2025}, }
• (2025). Photo-controlled dynamics of cholesteric polymer coatings via hydrazone crosslinking. ANGEW, 64(31), e202507358. (www)

  @article{ , abstract = {Developing responsive coatings and materials requires discovering a breadth of mechanisms by which external stimuli can be converted into useful signals. Here, we demonstrate an approach driven by supramolecular mechanochemistry, where mechanical input—molecular shape change—is translated into structural color variation. By embedding bistable, negatively photochromic hydrazone photoswitches into cholesteric polymer networks, we achieve a reversible, stable color shift through molecular-scale pulling and pushing of the photonic scaffold. Unlike azobenzene-based systems, which typically disrupt liquid crystal order, this approach modifies the pitch of a cross-linked cholesteric helix without disrupting the organisation of the material. The long-lived stability of both hydrazone isomers ensures durable optical switching. This effect provides a new strategy for designing mechanoresponsive photonic coatings and tunable optical materials.}, archive = {J_ANGEW}, author = {Alexander Ryabchun and Yunita Florida and Quan Li and Rémi Plamont and Nathalie Katsonis and Ivan Aprahamian}, doi = {10.1002/anie.202507358}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507358}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-controlled dynamics of cholesteric polymer coatings via hydrazone crosslinking}, volume = {64}, year = {2025}, }
• (2025). Protein secondary structure patterns in short-range cross-link atlas. ANGEW, 64(31), e202507348. (www)

  @article{ , abstract = {Cross-linking mass spectrometry (XL-MS) has become a powerful tool in structural biology for investigating protein structure, dynamics, and interactomics. However, short-range cross-links, defined as those connecting residues fewer than 20 positions apart, have traditionally been considered less informative and largely overlooked, leaving significant data unexplored in a systematic manner. Here, we present a system-wide analysis of short-range cross-links, demonstrating their intrinsic correlation with protein secondary structure. We introduce the X-SPAN (Cross-link Structural Pattern Analyzer) software, which integrates publicly available XL-MS datasets from system-wide experiments with AlphaFold-predicted protein structures. Our analysis reveals distinct cross-linking patterns that reflect the spatial constraints imposed by secondary structural elements. Specifically, α-helices exhibit periodic cross-linking patterns consistent with their characteristic helical pitch, whereas coils and β-strands display nearly monotonic distributions. A context-dependent protein grammar reinforces short-range cross-link specificity. Short-range cross-links can enhance the statistical inference of secondary structures within integrative modeling workflows. Additionally, our work establishes a framework for benchmarking AlphaFold's local prediction accuracy and provides novel quality control criteria for XL-MS experiments. We anticipate that X-SPAN and our short-range cross-link database will serve as a valuable resource for exploring local secondary structure rearrangements and their potential roles in protein function and allosteric regulation.}, archive = {J_ANGEW}, author = {Alice Vetrano and Alessio Di Ianni and Nico Di Fonte and Gianluca Dell'Orletta and Samantha Reale and Isabella Daidone and Claudio Iacobucci}, doi = {10.1002/anie.202507348}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Protein secondary structure patterns in short-range cross-link atlas}, volume = {64}, year = {2025}, }
• (2025). Dynamic evolution of structural ordering and aluminum redistribution during ZSM-5 zeolite crystallization. ANGEW, 64(31), e202507223. (www)

  @article{ , abstract = {Improving the comprehension of intricate crystallization processes at the molecular level is crucial for the customized design of efficient zeolite materials. However, the alternating dominance of classical and non-classical crystallization mechanisms, especially in multi-component solutions (monomers, oligomers, and amorphous particles), complicates mechanistic differentiation. Herein, we unveiled the structure and composition changes of ZSM-5 zeolite at various stages via selectively removing soluble species from the synthesis solution. We revealed that highly ordered, aluminum-rich subcrystals serve as essential precursors, triggering rapid non-classical aggregation growth, followed by a ripening phase dominated by single-molecule addition. Notably, aluminum species are excluded from the aggregation growth process and reincorporated via monomer addition, accounting for the compositional heterogeneity and an aluminum-enriched surface of the final product. Remarkably, for the first time, the fact and reason behind the preferential formation of aluminum-rich nuclei, as well as the changes in Al species during the rapid growth and ripening stages have well been thoroughly verified and clarified through syngas to aromatics reaction and theoretical simulations. These findings provide valuable theoretical guidance for the directional synthesis of zeolite and the control of dynamic process variables.}, archive = {J_ANGEW}, author = {Ke Du and Xiao Zhang and Tianyu He and Wei Shen and Hualong Xu and Yi Tang and Xiao-Ming Cao and Zhen Huang and Yahong Zhang}, doi = {10.1002/anie.202507223}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic evolution of structural ordering and aluminum redistribution during ZSM-5 zeolite crystallization}, volume = {64}, year = {2025}, }
• (2025). Topologically entangled network polymer electrolyte with Ionophilic–Protonation dual side chains for high-voltage lithium-metal batteries. ANGEW, 64(31), e202507222. (www)

  @article{ , abstract = {The development of high-voltage solid-state lithium-metal batteries (HVSSLMBs) is severely limited by unstable ion transport, insufficient oxidative stability, and poor electrode–electrolyte interface (EEI) compatibility of conventional solid electrolytes. Herein, we report a topologically entangled polymer electrolyte featuring ionophilic–protonation dual side chains. The ionophilic functional groups on these side chains provide abundant coordination sites, significantly enhancing Li + transport, whereas exposed carboxyl (─COOH) groups induce protonation on the cathode surface, effectively suppressing transition metal (TM) ion migration. The topologically entangled polymer network ensures uniform electric-field distribution, mitigates lattice-oxygen release, and maintains continuous Li + conduction. As a result, this electrolyte achieves a high room-temperature ionic conductivity of 0.81 mS cm −1 and an oxidation stability up to 4.9 V. Moreover, the in situ formed inorganic species (LiF, Li 2 O, and Li 2 CO 3 ) stabilized the EEI, enabling stable cycling of the symmetric cell for 2000 h. Batteries assembled with a high-voltage Li 1.2 Ni 0.13 Mn 0.54 Co 0.13 O 2 (LRMO) cathode retain a specific capacity of 217.37 mAh g −1 after 250 cycles, and Ah-level pouch cell utilizing LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811) cathode exhibits stable cycling performance over 150 cycles. These findings demonstrate the great promise of this strategy for the development of high-energy-density lithium-metal batteries with outstanding cycling performance and long-term stability.}, archive = {J_ANGEW}, author = {Longjie He and Yiting Shao and Shibin Li and Yihang Nie and Ying Chu and Guo Feng and Xuancheng Liu and Qingying Li and Dan Luo and Xin Wang and Zhongwei Chen}, doi = {10.1002/anie.202507222}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507222}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topologically entangled network polymer electrolyte with Ionophilic–Protonation dual side chains for high-voltage lithium-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Isothiourea-catalysed acylative kinetic and dynamic kinetic resolution of planar chiral paracyclophanols. ANGEW, 64(31), e202507126. (www)

  @article{ , abstract = {The development of synthetic methods for the catalytic enantioselective preparation of planar chiral paracyclophane derivatives is of considerable interest to the synthetic community. To date, relatively few successful and effective organocatalytic approaches to this molecular class have been reported. This manuscript describes effective isothiourea catalysed acylative kinetic (KR) and dynamic kinetic resolution (DKR) approaches to the generation of a range of planar chiral paracyclophane macrocycles with excellent levels of enantioselectivity. Effective KR of configurationally stable planar chiral paracyclophanols with 12- and 13-membered ansa -chains is demonstrated (6 examples, s = up to 50) using 5 mol% of the isothiourea ( R )-BTM and isobutyric anhydride. Application to configurationally labile macrocyclic phenols with 14 to 18-membered ansa -chains allows their effective acylative DKR, generating the desired products with excellent enantioselectivity (25 examples, up to 95% yield and 98:2 er).}, archive = {J_ANGEW}, author = {Zhanyu Zhou and Kevin Kasten and Aidan P. McKay and David B. Cordes and Andrew D. Smith}, doi = {10.1002/anie.202507126}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507126}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isothiourea-catalysed acylative kinetic and dynamic kinetic resolution of planar chiral paracyclophanols}, volume = {64}, year = {2025}, }
• (2025). Photoexcited hole-enabled synthesis of surface high-valent cobalt-oxo species with water as the oxygen atom source for water purification. ANGEW, 64(31), e202507085. (www)

  @article{ , abstract = {High-valent cobalt-oxo species (Co IV ═O) are key intermediates in catalytic chemistry but suffer a great challenge in their efficient and mild synthesis due to the strong electronic repulsion between the cobalt center and the oxygen ligand. Herein, we report a new approach to synthesizing surface Co IV ═O on the Co 3 O 4 /BiVO 4 (CoBi) catalyst via a photoexcited hole-induced process using water as the oxygen atom source. The interfacial Co 2+ ─O─Bi 3+ bonds act as the atomic-level channels to directionally transport photoexcited holes driven by the internal electric field effect. It has been found that H 2 O was photolyzed to cobalt-coordinated hydroxyls that were turned to Co IV ═O via a photoexcited hole-induced deprotonation. The isotopic labeling experiments confirmed that the oxygen atom source of Co IV ═O was derived from water rather than chlorite. A synergistic effect was formed between photocatalysis and transition metal-catalyzed chlorite activation, which enhanced the degradation of sulfadiazine (SDZ) and elevated the conversion ratio of chlorite to chlorine dioxide (ClO 2 ) from 40% to 60%. The present work has elucidated the essential role of H 2 O and photoexcited holes in the formation of Co IV ═O and provides a viable strategy to synthesize surface high-valent metal species utilizing ubiquitous water and sunlight for water purification.}, archive = {J_ANGEW}, author = {Ruidian Su and Zhen Liu and Jieshan Qiu and Nan Li and Xing Xu and Baoyu Gao and Qian Li}, doi = {10.1002/anie.202507085}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202507085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoexcited hole-enabled synthesis of surface high-valent cobalt-oxo species with water as the oxygen atom source for water purification}, volume = {64}, year = {2025}, }
• (2025). Engineering robust Hydrophilic–Hydrophobic interface via π-electron delocalization for ultralong-lived Zinc–Ion batteries. ANGEW, 64(31), e202506984. (www)

  @article{ , abstract = {Aqueous zinc ion batteries (AZIBs) are hindered by the severe interfacial issues of Zn anode such as side reactions and dendrite growth. The in-situ construction of robust interface to tackle above issues remains a grand challenge and lacks rational design principles, especially under high current density. Herein, a π-electron delocalization strategy is proposed to in-situ construct the self-assembled hydrophilic–hydrophobic interface layer (HHIL) for ultralong-lived AZIBs, where interface design principles are built based on the electronic structure and spatial configuration of additives. Encouragingly, HHIL derived by π-π interactions and ion–dipole interactions is robust during long-term cycling and facilitates the generation of an inorganic-rich interface chemistry. The flexible HHIL and rigid inorganic-rich interface afford the rapid interface kinetics, and effectively suppresses side reactions and dendrite growth. Notably, Zn//Zn cells deliver the cycling life over 900 h at 20 mA cm −2 and 10 mAh cm −2 , and Zn//NVO full cells stably perform over 25 000 cycles at 10 A g −1 . Furthermore, the practical pouch cell is also demonstrated.}, archive = {J_ANGEW}, author = {Yudong Sang and Jing Wang and Mi Xu and Beinuo Zhang and Qiongying Huang and Dongdong Wang and Chuangwei Liu and Yatao Zhang and Haozhen Dou and Zhongwei Chen}, doi = {10.1002/anie.202506984}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506984}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering robust Hydrophilic–Hydrophobic interface via π-electron delocalization for ultralong-lived Zinc–Ion batteries}, volume = {64}, year = {2025}, }
• (2025). Hydrogen bond-assisted PCET and formation of WIII─OH in Bis(Dithiolene) complex. ANGEW, 64(31), e202506861. (www)

  @article{ , abstract = {The redox non-innocent nature of dithiolene ligands is well known for stabilizing high-valent metal ions and facilitating proton-coupled electron transfer (PCET) processes. Until now, proton reactivity at the dithiolene site has been primarily associated with low-valent metal centers, as high-valent metal-dithiolene complexes were not considered viable for such reactivity. This study introduces high-valent bis(dithiolene) tungsten (W)-oxo complexes featuring hydrogen-bonding interactions, unveiling a novel proton reduction mechanism mediated by the dithiolene moiety. The process begins with a nucleophilic W-oxo, forming a hydrogen bond, followed by a second hydrogen bond at the dithiolene-sulfur (S) site. These hydrogen-bonding interactions significantly modulate the molecular orbital energy levels, enabling the W IV→III reduction at −1.75 V ( E exp ) and allowing, for the first time, the acquisition of an EPR spectrum of a W III ─OH intermediate species. In contrast, direct electron transfer into the W IV ═O state would populate the dithiolene π* orbital, demanding substantially larger energy ( E cal = −3.45 V). For catalytic proton reduction, the proton transfer through the dithiolene-S site was identified as the energetically most favorable pathway for generating the W V ─H catalytic species.}, archive = {J_ANGEW}, author = {Wonjung Lee and Daeyong Um and Yujin Baek and Sugyeong Hong and Youngseob Lee and Jaeheon Lee and Jin Kim and Sun Hee Kim and Kyung-Bin Cho and Junhyeok Seo}, doi = {10.1002/anie.202506861}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506861}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen bond-assisted PCET and formation of WIII─OH in Bis(Dithiolene) complex}, volume = {64}, year = {2025}, }
• (2025). Small fluorinated aromatic molecule-based radiofrequency identification tags enabled by stepwise tuning of nuclear shielding. ANGEW, 64(31), e202506846. (www)

  @article{ , abstract = {In the Internet of Things (IoT) network, radiofrequency identification (RFID) is a key enabler for wireless communication, facilitating real-time monitoring and control. A primary goal of enhancing IoT infrastructure is the development of versatile RFID tags that are of compact size, high capacity, and robust security with seamless read-write operations. Here, we report a fluorine-19 nuclear magnetic resonance ( 19 F NMR)-based molecular encoding strategy using a fluorinated aromatics (FArs) library, termed “FArsEER” (fluorinated aromatics-empowered encoding and reading), to generate small molecule-based ID tags (Farcodes). By leveraging the structure-sensitive nature of 19 F chemical shift, we developed a stepwise tuning strategy to precisely modulate 19 F chemical shift via nuclear shielding. Through a simple one-step synthesis, we constructed a demonstrating platform of 64 FArs with distinct 19 F chemical shifts, enabling the quick generation of binary Farcodes capable of 64-bit encoding and their facile reading and decoding with 19 F NMR. Moreover, by leveraging the solvent-dependent 19 F chemical shifts and hydrolysis-sensitive property, reversible encryption and irreversible erasure were further achieved with Farcodes for information security applications. With further advancements, Farcode may serve as a promising small molecule-based RFID tag for secure information storage and communication in IoT networks.}, archive = {J_ANGEW}, author = {Yuhang Jiang and Limin Chen and Junjie Wang and Hongyu Lin and Jinhao Gao}, doi = {10.1002/anie.202506846}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506846}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Small fluorinated aromatic molecule-based radiofrequency identification tags enabled by stepwise tuning of nuclear shielding}, volume = {64}, year = {2025}, }
• (2025). Redirecting the peptide cleavage causes protease inactivation. ANGEW, 64(31), e202506832. (www)

  @article{ , abstract = {Cysteine and serine proteases cleave peptides through covalent catalysis by generating a transient adduct with the N-terminal part of the substrate after releasing its C-terminal part. We demonstrate the unique redirection of this event leading to strong enzyme inactivation. For targeting human cathepsin B, a cysteine protease of significant therapeutic importance, we designed tailored peptidomimetics with a variety of dipeptide fragments directed toward the occluding loop and equipped with numerous N-terminal carbamate warheads. The carbamate deprotonation catalyzed by the active site thiolate initiates the redirected cleavage. The C-terminal part of the inhibitors remains covalently attached to the protease. Hydrolysis of such carbamoyl-enzyme complexes is catalytically unsupported rendering inhibition irreversible. This novel mechanism of action comprises a significant extension of the covalent drug space.}, archive = {J_ANGEW}, author = {Christian Breuer and Jim Küppers and Anna-Christina Schulz-Fincke and Anna Heilos and Carina Lemke and Petra Spiwoková and Janina Schmitz and Laura Cremer and Marta Frigolé-Vivas and Michael Lülsdorff and Matthias D. Mertens and Filip Wichterle and Miloš Apeltauer and Martin Horn and Erik Gilberg and Norbert Furtmann and Jürgen Bajorath and Ulrike Bartz and Bernd Engels and Michael Mareš and Michael Gütschow}, doi = {10.1002/anie.202506832}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506832}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redirecting the peptide cleavage causes protease inactivation}, volume = {64}, year = {2025}, }
• (2025). “Pseudo-charge-transfer complex” electrolyte enables 490 wh kg−1 lithium metal battery operated from −40 to 80 °C. ANGEW, 64(31), e202506750. (www)

  @article{ , abstract = {Electric vehicles and electric aircraft demand all-climate lithium metal batteries (LMBs) with high energy density. However, the interaction mechanism between charge transfer in the solvation sheath and interfacial evolution is not yet clear. Herein, we proposed a “pseudo-charge-transfer complex” strategy by introducing an amide polymer encapsulation matrix (APEM) to construct local charge-transfer channels to solvents for tuning the negative charge center. Theoretical calculations and synchrotron X-ray tomography reveal that the APEM drags out the polar solvent and promotes cation-anion coordination in the primary solvation sheath, contributing to AGGs-dominated interfacial solvation chemistry. The designed electrolyte improves the cyclability of Li|LiNi 0.9 Co 0.05 Mn 0.05 O 2 up to 300 cycles at 4.6 V and high-temperature capability at 80 °C. Even at −40 °C, it still delivers a high capacity of 87.9 mAh g −1 with negligible capacity decay for 160 cycles. Industrial 3 Ah-level pouch cells over 490 Wh kg −1 exhibit 91.3% capacity retention after 100 cycles, manifesting high potential in extreme applications.}, archive = {J_ANGEW}, author = {Shengwei Dong and Lingfeng Shi and Yan Zhang and Shenglu Geng and Zhuomin Qiang and Biao Deng and Fei Sun and Hua Huo and Geping Yin and Shuaifeng Lou}, doi = {10.1002/anie.202506750}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506750}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Pseudo-charge-transfer complex” electrolyte enables 490 wh kg−1 lithium metal battery operated from −40 to 80 °C}, volume = {64}, year = {2025}, }
• (2025). Chiral diazatriptycene exhibiting acid-induced ternary circularly polarized luminescence switching and crystal morphology changes. ANGEW, 64(31), e202506733. (www)

  @article{ , abstract = {Doubly N -doped triptycene 2,6-diazatriptycene 1 was synthesized as the first example of triptycene-bearing intrinsic chirality in its core. The resolved enantiomers exhibited an acid-induced ternary circularly polarized luminescence (CPL) switching behavior, enabling on/off and +/− control, with a dissymmetry factor ( g lum ) of approximately 10 −3 . Density functional theory calculations indicated that these ternary CPL changes were derived from modulation of through-space conjugation within the triptycene skeleton. In addition, single-crystal X-ray analysis of 1 and the salt 1 •(TfOH) n revealed the presence of herringbone arrangements, trimer clusters, chiral porous tubes, and 2D charge-segregated array structures. These results demonstrate that precise change of the molecular assembly can be achieved using N -doped chiral triptycene facilitated by ionic hydrogen bonding and donor-acceptor π-π stacking.}, archive = {J_ANGEW}, author = {Ryo Inoue and Atsushi Aoki and Tomohiro Agou and Yasuhiro Morisaki}, doi = {10.1002/anie.202506733}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506733}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral diazatriptycene exhibiting acid-induced ternary circularly polarized luminescence switching and crystal morphology changes}, volume = {64}, year = {2025}, }
• (2025). The role of reducibility of PtGaOx-based catalysts for efficient and durable propane dehydrogenation. ANGEW, 64(31), e202506704. (www)

  @article{ , abstract = {Although PtGaO x -containing catalysts are active and selective in the non-oxidative dehydrogenation of propane (PDH) to propylene, they suffer from rapid deactivation and, especially, inability to recover their initial performance in a series of PDH/oxidative regeneration cycles, characteristics that are highly relevant to commercialization. Herein, we identified reducibility of GaO x as the key descriptor affecting the above catalyst features. Oxidized GaO x species are more active than reduced GaO x in the recombination of two H species formed from propane, which is the rate-limiting step in the PDH reaction. This process is further accelerated by Pt. The reduction of GaO x with time on propane stream leads to catalyst deactivation. Easily reducible GaO x also tend to form PtGaO x under PDH conditions, from which Pt atoms present in fresh catalysts cannot be completely recovered during oxidative regeneration, which is detrimental to catalyst durability. Regardless of the reaction atmosphere, Pt single atoms exist on the surface of PtGaO x -containing catalysts with hardly reducible GaO x . Based on the knowledge derived, we developed a catalyst with 500 ppm Pt on the surface of mixed GaAlO x , which outperforms almost all previous PtGaO x -containing catalysts in terms of space-time yield of propylene formation and shows durable operation under industrially relevant conditions.}, archive = {J_ANGEW}, author = {Kai Wu and Vita A. Kondratenko and Mingxia Zhou and Dmitry E. Doronkin and Stephan Bartling and Qiyang Zhang and Shanlei Han and Xin Jia and Qi Liu and Dong Xiong and Chunming Xu and Guiyuan Jiang and Dan Zhao and Uwe Rodemerck and David Linke and Evgenii V. Kondratenko}, doi = {10.1002/anie.202506704}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506704}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The role of reducibility of PtGaOx-based catalysts for efficient and durable propane dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Metal-free electrochemistry-driven decarboxylative primary alkyl-alkoxylation of olefins. ANGEW, 64(31), e202506639. (www)

  @article{ , abstract = {Here, a primary alkylative difunctionalization of olefins based on the decarboxylation of carboxylate ions to obtain alkyl radicals by electrochemical anodic oxidation is reported. The reaction employs quaternary ammonium carboxylates as the source of alkyl radicals and does not require additional oxidizing agents or electrolytes. The reaction exhibits a broad substrate range and functional group compatibility. It gently converts mono- or disubstituted styrene substrates and alkyl carboxylate anions of various carbon chain lengths and substituents to products under the reaction conditions. Furthermore, it is important to note that not only alcohols but carboxylic acids and water can also serve as nucleophilic reagents to participate in the reaction and yield the corresponding products. Preliminary mechanistic studies have demonstrated that the reaction is enabled by the lower oxidation potential of the carboxylate anion compared to that of the olefin. The anodic oxidation of the carboxylate anion occurs prior to the oxidation of the olefin, followed by decarboxylation to obtain alkyl radicals.}, archive = {J_ANGEW}, author = {Meiqun Lu and Kailun Chen and Tao Wu and Hu Cai}, doi = {10.1002/anie.202506639}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506639}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-free electrochemistry-driven decarboxylative primary alkyl-alkoxylation of olefins}, volume = {64}, year = {2025}, }
• (2025). Lattice compression-driven electron localization and ir-O coupling synergistically enable ultralow overpotential li-CO2 batteries. ANGEW, 64(31), e202506635. (www)

  @article{ , abstract = {Developing efficient cathode catalysts plays a crucial role in improving the CO 2 reduction reaction (CO 2 RR) and CO 2 evolution reaction (CO 2 ER) kinetics in Li–CO 2 batteries. However, the chemical stability of the wide-bandgap insulator Li 2 CO 3 severely hinders the CO 2 ER. To address this challenge, this study proposes a lattice compression strategy in which electronic localization accelerates the CO 2 RR, thereby enhancing Ir–O coupling and inducing the formation of low-crystallinity Li 2 CO 3 , ultimately optimizing the CO 2 ER process. This approach enables the Li–CO 2 battery to achieve an ultralow overpotential of 0.33 V and an exceptionally high energy efficiency of ∼88.7%. Moreover, even after over 1100 h of operation, the battery maintains a stable charging potential of 3.3 V, representing the best performance reported to date. Through in situ and ex situ characterizations combined with theoretical calculations, we reveal that lattice compression leads to changes in the coordination environment, thereby enhancing electronic localization effects. This accelerates Li + migration near the catalyst surface, facilitating its rapid participation in CO 2 RR. Subsequently, the strengthened Ir–O coupling modulates the symmetry of Li 2 CO 3 molecules, reduces their crystallinity, and ultimately promotes their efficient decomposition. This study provides new insights into the design of high-performance bidirectional cathode catalysts through crystal facet engineering.}, archive = {J_ANGEW}, author = {Jiyuan Xiao and Limin Liu and Shuyang Ren and Menghang Sun and Bo Wen and Song Xue and Shuai Yang and Xiaofeng Liu and Ning Zhao and Xiaofei Hu and Shujiang Ding and Guorui Yang}, doi = {10.1002/anie.202506635}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506635}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lattice compression-driven electron localization and ir-O coupling synergistically enable ultralow overpotential li-CO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Unexpected activities of CYP152 peroxygenases toward non-carboxylic substrates reveal novel substrate recognition mechanism and catalytic versatility. ANGEW, 64(31), e202506614. (www)

  @article{ , abstract = {Exploring and exploiting the catalytic promiscuity of enzymes is a central topic and captivating challenge in enzymology. CYP152 peroxygenases are attractive biocatalysts for diverse reactions under mild conditions using H 2 O 2 as cofactor. However, their substrate scope is limited by a carboxyl group required for substrate assisted acid-base catalysis, following the well-accepted principle that heme-dependent H 2 O 2 -utilizing enzymes employ a carboxyl group within their active sites to facilitate H 2 O 2 activation. Herein, we reveal for the first time that several CYP152 family members can directly degrade various aromatic pollutants without any carboxyl group, exhibiting novel aromatic hydroxylation and dehalogenation activities. Through crystal structure analysis, isotope tracing experiments, and QM/MM calculations, we elucidate that the phenolic hydroxyl group activated by electron-withdrawing substituent(s) functionally replaces the carboxyl group, forming hydrogen bonds with the conserved arginine leading to Compound I formation. The oxygen atom of the newly formed hydroxyl group originates from water, bypassing the conventional oxygen rebound step. These findings provide first insights into the mechanisms of P450 peroxygenases toward non-carboxylic substrates, expanding our knowledge of biological C─H activation and C-halogen bond cleavage beyond canonical P450 reactions. This discovery holds immense potential for harnessing these enzymes in innovative strategies for industrial biocatalysis and environmental remediation.}, archive = {J_ANGEW}, author = {Yuanyuan Jiang and Piqian Gong and Zijia Li and Zhong Li and Yuxuan Li and Binju Wang and He Huang and Wei Peng and Xiang Gao and Shengying Li}, doi = {10.1002/anie.202506614}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506614}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unexpected activities of CYP152 peroxygenases toward non-carboxylic substrates reveal novel substrate recognition mechanism and catalytic versatility}, volume = {64}, year = {2025}, }
• (2025). Synthesis of chroman derivatives by group transposition and atom swapping in 1-tetralones: Single-atom editing enabled by oxidative ring contraction of benzoxepine silyl ketene acetals. ANGEW, 64(31), e202506564. (www)

  @article{ , abstract = {Single-atom editing of complex molecules is steadily filling the chemical toolbox with site-selective modification reactions. Herein, a stepwise scheme for carbon-to-oxygen swap in tetralins leading to privileged chroman scaffolds is presented. Increasing the oxidation state at each stage, the substrate scope naturally extends: starting from tetralins via 1-tetralones and further via seven-membered lactones, the transformation results in diverse chroman-2-carboxylic acids and chroman-2-ols. The efficiency of this synthetic route is governed by the developed new oxidative ring-contractive transformations of tetrahydrobenzooxepinones, enabled by intermediate silylation into ketene acetals. The described carbon-to-oxygen swap is illustrated by 40+ examples, including skeletal editing of natural products and short formal synthesis of Heliannuol E. Formation of chroman-2-ols tentatively may proceed via original mechanism with extrusion of carbon monoxide.}, archive = {J_ANGEW}, author = {Viktoria A. Ikonnikova and Pavel N. Solyev and Amir M. Al Mufti and Kirill D. Kungurtsev and Alexander A. Korlyukov and Mikhail S. Baranov and Andrey A. Mikhaylov}, doi = {10.1002/anie.202506564}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506564}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of chroman derivatives by group transposition and atom swapping in 1-tetralones: Single-atom editing enabled by oxidative ring contraction of benzoxepine silyl ketene acetals}, volume = {64}, year = {2025}, }
• (2025). Single-crystal-to-single-crystal transformation in a thermally stable all-inorganic polyoxoniobate framework boosts lithium ion battery anode performance. ANGEW, 64(31), e202506533. (www)

  @article{ , abstract = {Niobium oxides are considered as promising anode materials for lithium-ion batteries (LIBs) due to their excellent rate-performance. However, the practical application is hindered by their limited specific capacity. In this work, we report the first example of an all-inorganic two-dimensional (2D) niobate framework as anode material for LIBs. The title compound is based on antimony-linked bivanadyl-capped α -Keggin polyoxoniobates as secondary building units. The compound undergoes a unique single-crystal-to-single-crystal (SCSC) transformation triggered by formic acid which results in the migration of a {VO} unit into the framework interlayer. This results in a 34% increase of the specific capacity, reaching 519 mAh g −1 at 0.1 A g −1 , thereby surpassing most Nb-based LIB anode materials. Experimental and theoretical calculations reveal that the SCSC transformation exposes more Li-binding sites in the framework, and reduces the interlayer Li-ion diffusion barrier, leading to a capacity increase. This work presents the first example of a SCSC transformation leading to enhanced LIB performance and offers atomic-level insights into the design of advanced LIB anode materials.}, archive = {J_ANGEW}, author = {Cai Sun and Jian-Ping Chen and Yan-Lan Wu and Yi-Ying Li and Xin-Xiong Li and Ping-Wei Cai and Carsten Streb and Shou-Tian Zheng}, doi = {10.1002/anie.202506533}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506533}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-crystal-to-single-crystal transformation in a thermally stable all-inorganic polyoxoniobate framework boosts lithium ion battery anode performance}, volume = {64}, year = {2025}, }
• (2025). Microhydration dynamics in molecular photoswitches: Equilibrium state reconfiguration in imine-based architectures. ANGEW, 64(31), e202506531. (www)

  @article{ , abstract = {The functional performance of a molecular photoswitch relies strongly on its ability to undergo structural changes in solution. In this context, microsolvation studies in the gas phase provide access to the conformational panorama of these systems in a size-controlled hydrated environment. Here, we exploit this gas-phase vantage point alongside quantum-chemistry calculations to study the structural properties and microhydration dynamics of camphorquinone imine, a chiral molecule holding the functionality to engage in a motor-like function upon light activation. Using molecular rotational resonance spectroscopy with supersonic jets, we detect and analyze the first- and second-order water complexes of the chiral imine. Our findings reveal that initial hydration steps significantly impact the equilibrium between open (E) and closed (Z) forms, culminating in a reversal of relative stability for the switch states. Despite being captured at rotational temperatures near 1 K, we find that water molecules exhibit notable mobility due to the lack of prominent stabilizing secondary interactions. Additionally, the assignment of a key higher-energy closed (Z) water complex provides insights into the energy required for switching between (E) and (Z) states during collisional cooling. We discuss these effects and rationalize them in terms of molecular forces and internal dynamics governing early solvation.}, archive = {J_ANGEW}, author = {Nuno M. Campos and Rita J. C. Roque and Pablo Pinacho and Corina H. Pollok and Christian Merten and Pedro S. P. Silva and Manuela R. Silva and Melanie Schnell and Sérgio R. Domingos}, doi = {10.1002/anie.202506531}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506531}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Microhydration dynamics in molecular photoswitches: Equilibrium state reconfiguration in imine-based architectures}, volume = {64}, year = {2025}, }
• (2025). Negatively curved diaza-octagon heterocycle fused with polycyclic aromatic hydrocarbons for ultra-narrowband deep-blue emission. ANGEW, 64(31), e202506504. (www)

  @article{ , abstract = {Developing new polycyclic aromatic hydrocarbons (PAHs) skeletons with narrowband emission is crucial for advancing ultra-high-definition displays. Inspired by the aesthetic configuration of negatively curved octagonal rings and the multiple resonance (MR) effect, we designed a novel diaza-octagon heterocycle fused with PAHs, abbreviated as 8NN, and its phenyl-substituted derivative 8NNP. Crystal data and theoretical calculations show that their peripheral PAHs exhibit significant rigidity, while the internal diaza-octagon ring confers skeleton flexibility and flipping properties. Notably, owing to the strategic embedding and unique bonding form of nitrogen atoms, their MR effect is significantly enhanced. Finally, 8NN and 8NNP achieve deep-blue emission peaking at 408 and 411 nm, with remarkably narrow full-width at half-maximum (FWHM) of 19 and 17 nm, respectively, and aggregation-enhanced emission characteristics. Additionally, to further tune emission range of this new skeleton, boron-functionalized 8NNB was synthesized, achieving blue emission peaking at 461 nm in toluene, with a FWHM of 31 nm. Finally, the OLEDs based on 8NNP and 8NNB exhibit maximum external quantum efficiencies of 3.47% and 24.24%, with CIE coordinates of (0.172, 0.043) and (0.132, 0.256), respectively. These results validate the rational design of the novel skeleton and facilitate the development of narrowband emission materials.}, archive = {J_ANGEW}, author = {Baoxi Li and Yadong Qu and Jingli Lou and Lu Liu and Yu Huang and Han Zhang and Ben Zhong Tang and Zhiming Wang}, doi = {10.1002/anie.202506504}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506504}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Negatively curved diaza-octagon heterocycle fused with polycyclic aromatic hydrocarbons for ultra-narrowband deep-blue emission}, volume = {64}, year = {2025}, }
• (2025). Atomic heterointerface engineering and nonequilibrium carrier dynamics for enhanced photocatalysis in halide Perovskite/MoS2 systems. ANGEW, 64(31), e202506436. (www)

  @article{ , abstract = {Halide perovskites hold promise for solar-driven photocatalysis in fuel production owing to their superior light absorption and carrier diffusion. However, precise control and understanding of interfacial charge separation dynamics in their heterostructures remain challenging. Using formamidinium lead bromide/molybdenum disulfide (FAPbBr 3 /MoS 2 ) as a model, we engineered Pb-rich, Pb-neutral, and Pb-deficient surfaces via precursor stoichiometry tuning, modulating interface coupling through Pb─S bonds. High-density atomic bridging in Pb-rich interfaces boosts photogenerated charge separation efficiency from 29% to 63%, yielding a 98-fold hydrogen production increase and record 8.69% solar-to-hydrogen efficiency. Theoretical and experimental results demonstrate that the long carrier diffusion length and high photogenerated charge density of perovskites create a steep charge density gradient at the interface. This gradient directly induces a nonequilibrium internal electric field, which governs the charge transport dynamics. This work demonstrates the feasibility of sophisticated heterointerface tailoring and advances the understanding of the driving forces behind interfacial charge separation for perovskite photocatalysts.}, archive = {J_ANGEW}, author = {Changhai Guo and Jia Guo and Wei Song and Shaomin Peng and Ming Sun and Guichuan Xing and Lin Yu}, doi = {10.1002/anie.202506436}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506436}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic heterointerface engineering and nonequilibrium carrier dynamics for enhanced photocatalysis in halide Perovskite/MoS2 systems}, volume = {64}, year = {2025}, }
• (2025). Regulating solvating sites for stable high-voltage lithium metal batteries. ANGEW, 64(31), e202506395. (www)

  @article{ , abstract = {The long-lasting stability of high-voltage lithium metal batteries (LMBs) critically rely on both the cathodic and anodic stability of electrolytes, which can be enhanced by increasing the salt-to-solvent molar ratio. However, this approach is limited by solubility constraints. In this work, we introduce a dual-anchoring strategy to regulate the solvating sites of glymes via directional atomic interactions. Specifically, F δ− –H δ+ interactions transform the Li + -glyme coordination and induce more anion coordination within Li + primary solvation sheath, whereas H δ+ –O δ− interactions reduce the electron density at free oxygen sites, thus raising the oxidational potential of glyme and enhancing the overall oxidation stability of electrolytes. This strategy results in an electrolyte with exceptional compatibility with both lithium metal anode (LMA) and high-voltage cathode, enabling LMA with an ultrahigh coulombic efficiency (CE) of 99.76%. Furthermore, the assembled LMBs exhibit extended lifespans, retaining 80% of their capacity under aggressive conditions: 834 and 370 cycles at 4.4 and 4.5 V, respectively, for 30-µm-Li||2.0-mAh cm −2 LiNi 0.8 Co 0.1 Mn 0.1 O 2 cells and 100 cycles for anode-free Cu||LiNi 0.5 Co 0.2 Mn 0.3 O 2 pouch cells. This work offers novel insights into the advancement of next-generation LMBs based on ether-based electrolytes.}, archive = {J_ANGEW}, author = {Zeyuan Liu and Shuoqing Zhang and Haikuo Zhang and Baochen Ma and Haotian Zhu and Tao Zhou and Long Li and Xuezhang Xiao and Ruhong Li and Lixin Chen and Tao Deng and Xiulin Fan}, doi = {10.1002/anie.202506395}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506395}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating solvating sites for stable high-voltage lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Reactivity of pnictaalumenes towards 1,3-dipole molecules. ANGEW, 64(31), e202506356. (www)

  @article{ , abstract = {Alkynes undergo 1,3-dipolar cyclization reactions with organic azides giving 1,2,3-triazoles. Pnictaalumenes RPn═AlRˈ are the isoelectronic congeners of alkynes, hence a similar reactivity toward 1,3-dipole molecules is expected. Herein, we report the reactions of Dipp TerPn═AlCp* ( Dipp Ter  =  2,6-(2,6- i Pr 2 C 6 H 3 )-C 6 H 3 , Cp*  =  [Me 5 C 5 ], Pn  =  P, As) toward aryl azides. Instead of the anticipated phosphaaluminatriazole products from a [3+2] cyclization, the formation of four-membered AlN 2 Pn ring systems of the general form Dipp TerPn( μ -NR) 2 AlCp* was observed. Depending on the steric profile of the azide, different outcomes were observed: a) N α insertion into the Pn═Al bond accompanied by twofold N 2 elimination, b) N γ insertion under preservation of the N 3 motif, or c) mixed N a /N γ products. The bonding situation is complex and best described as Al(III) complexes with NPnN-amino-amide-type ligands. A twofold insertion also occurs with the isovalent electronic diazoalkane Me 3 Si(H)C═N 2 , yielding imine-substituted AlN 2 Pn derivatives. In the case of its P-congener, two thermal rearrangements were observed, which first result in a AlN 3 P ring species with a terminal Al─CN unit, followed by a second slower rearrangement to an aluminate cyanido complex with an unusual NNN pincer-type ligand framework. The current study contrasts well-established [3+2] cyclization reactions between alkynes and 1,3-dipoles and provides access to unprecedented ligand motifs.}, archive = {J_ANGEW}, author = {Tim Wellnitz and Edgar Zander and Leonie Wüst and Jakob Boardman and Max Neubauer and Samuel Nees and Holger Braunschweig and Christian Hering-Junghans}, doi = {10.1002/anie.202506356}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506356}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reactivity of pnictaalumenes towards 1,3-dipole molecules}, volume = {64}, year = {2025}, }
• (2025). High-pressure synthesis of nitrogen-rich Y(N5)3·N2 pentazolate with perovskite topology. ANGEW, 64(31), e202506334. (www)

  @article{ , abstract = {The discovery and stabilization of the cyclo-N 5 ⁻ anion have introduced a class of pentazolate compounds with significant potential as high-energy-density materials (HEDMs). This potential could be further enhanced by increasing the pentazolate-to-metal ratio. Here, we report the high-pressure, high-temperature synthesis and characterization of a novel yttrium pentazolate, Y(N 5 ) 3 ·N 2 , which exhibits an exceptionally high nitrogen-to-metal ratio of 17:1. Y(N 5 ) 3 ·N 2 was synthesized from yttrium and nitrogen by laser heating to 3000 K at 125 GPa in a diamond anvil cell. Its crystal structure, a 3D nitrogen-inclusion metal-pentazolate framework, was solved and refined in situ using synchrotron single-crystal X-ray diffraction. This structure demonstrates a perovskite topology, as pentazolate ring centers form octahedra connected via vertices, neutral nitrogen dimers are located at the centers of the octahedra, and yttrium atoms occupy distorted cuboctahedra within the octahedral 3D framework. Density functional theory (DFT) calculations corroborate the experimental findings and provide further insights into the stability and properties of the synthesized compound. Y(N 5 ) 3 ·N 2 is the first example of stabilizing three pentazolate anions per metal cation, surpassing the previously achieved 1:1 ratio. Additionally, we propose a centroid-based structure typification for solvent-free inorganic pentazolates, serving as an important step for further structural classification of pentazolates and other polynitrides.}, archive = {J_ANGEW}, author = {Andrey Aslandukov and Yuqing Yin and Maxim Bykov and Alena Aslandukova and Fariia I. Akbar and Eleanor Lawrence Bright and Igor A. Abrikosov and Natalia Dubrovinskaia and Leonid Dubrovinsky}, doi = {10.1002/anie.202506334}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506334}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-pressure synthesis of nitrogen-rich Y(N5)3·N2 pentazolate with perovskite topology}, volume = {64}, year = {2025}, }
• (2025). Selective aerobic oxidation of toluene to benzaldehyde by parallel photoinduced proton-coupled electron transfer and energy transfer through multiphoton excitation. ANGEW, 64(31), e202506277. (www)

  @article{ , abstract = {Selectively aerobic oxidation of toluene to benzaldehyde is an important but challenging task due to the high proclivity of aldehydes to undergo over-oxidation to acids. Herein, we report a new multiphoton excitation approach for synthesizing benzaldehyde from toluene by integrating oxygen vacancy and proton-coupled electron transfer (PCET) events into one coordination polymer (Zn-AQ) to enhance efficiency and selectivity. Under light irradiation, the ligand facilitates photoinduced PCET and photoinduced energy transfer (EnT), generating radical species from the C(sp 3 )─H bonds and highly active 1 O 2 species. The π-stacking interactions between the ligands enforced the metal centers to form Zn⋅⋅⋅Na⋅⋅⋅Zn⋅⋅⋅Na polyoxometalate chains with oxygen vacancy sites for the selective oxidation of the radical intermediate. Zn-AQ endows the efficient and selective oxidation of aromatic benzyl C(sp 3 )─H bonds into aldehydes, including the conversion of toluene into benzaldehyde with the selectivity up to 94%, by combining the energies of three photons in one catalytic cycle. The first reported multiphoton catalytic strategy combines oxygen vacancy catalysis with PCET C(sp 3 )─H bond activation mode, providing new ideas for the design of aerobic oxidation photocatalysts for target C(sp 3 )─H bonds oxidation in a mild, efficient, and highly selective manner.}, archive = {J_ANGEW}, author = {Qingbo Shen and Jiali Chen and Xu Jing and Chunying Duan}, doi = {10.1002/anie.202506277}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506277}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective aerobic oxidation of toluene to benzaldehyde by parallel photoinduced proton-coupled electron transfer and energy transfer through multiphoton excitation}, volume = {64}, year = {2025}, }
• (2025). Oxidative electrocyclization assembles 2,2-dimethyl-2H-pyran in fungal indole alkaloids. ANGEW, 64(31), e202506276. (www)

  @article{ , abstract = {Pericyclic reactions, such as cycloaddition and electrocyclization, are among the most useful approaches for constructing complex natural products with diverse biological activities. While enzymatic pericyclic reactions have been increasingly reported in recent years, there are only a few examples of enzyme-mediated electrocyclization reactions. The 2,2-dimethyl-2 H -pyran (DMP) ring plays a significant role in constituting many bioactive fungal and plant natural products. In this study, we characterize the vsc biosynthetic gene cluster of the DMP-containing natural product versicamide A ( 1 ) in Aspergillus versicolor DL0022. The biosynthetic route for DMP formation and the biochemical functions of the involved enzymes are fully elucidated. Specifically, we reveal that the berberine bridge-like oxidoreductase VscB mediates a crucial oxidative process, followed by an electrocyclization to form a C─O bridge bond, thereby affording the key DMP ring. Structural simulation, molecular modeling, mutational analysis, and quantum chemical calculations elucidate the oxidative electrocyclization mechanism. The flavin adenine dinucleotide (FAD) cofactor of VscB/NotD' facilitates hydride abstraction at the C25 position of the substrate, while the key amino acid residue E529 acts as a general base to deprotonate the C6 hydroxyl group.}, archive = {J_ANGEW}, author = {Chengjie Zhang and Jingxuan Zhou and Wei Wang and Mingyu Liu and Yuanning Li and Xiang Sheng and Lei Du and Shengying Li}, doi = {10.1002/anie.202506276}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506276}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxidative electrocyclization assembles 2,2-dimethyl-2H-pyran in fungal indole alkaloids}, volume = {64}, year = {2025}, }
• (2025). Enhancing the built-in electric field of thickness-insensitive small molecule cathode interlayers for high-efficiency and stable organic solar cells. ANGEW, 64(31), e202506252. (www)

  @article{ , abstract = {The built-in electric field (BEF) is proposed as a critical design parameter for optimizing small-molecule cathode interlayer materials (SM-CIMs) in organic solar cells (OSCs). By strategically transforming imidazole-functionalized triads from a donor-acceptor-donor (D-A-D) to an A-D-A configuration and replacing the A unit with a more electron-deficient moiety, we developed three triads: (TBT) 2 NDI, (NDI) 2 TBT, and (PDI) 2 TBT, each exhibiting progressively enhanced BEF, along with improved conductivity, work function (WF) adjustability, energy level alignment, and crystallinity. Additionally, the A-D-A triads facilitate superior electronic communication with both non-fullerene acceptors (NFAs) and polymer donors, enhancing photoexcitation utilization and reducing triplet state formation. Consequently, transitioning from (TBT) 2 NDI to (NDI) 2 TBT and then to (PDI) 2 TBT significantly boosts OSC efficiency and operational stability. Notably, devices with (PDI) 2 TBT and (NDI) 2 TBT retain 85.0% and 82.3% of their peak efficiencies, respectively, far exceeding the (TBT) 2 NDI-based device (65.9%) at an interlayer thickness of approximately 105 nm. Furthermore, (PDI) 2 TBT exhibits excellent compatibility with various active layers, and an outstanding performance of 20.10% is recorded in the PM6:L8-BO:BTP-eC9 system. This comprehensive study, encompassing molecular design, theoretical simulation, device fabrication, and fundamental device physics, highlights the importance of strategic donor–acceptor (D-A) electronic framework modifications to enhance BEF, thereby advancing the development of sophisticated SM-CIMs for OSCs.}, archive = {J_ANGEW}, author = {Yuxing Wang and Junjie Wen and Zhe Shang and Yanyi Zhong and Huixiang Zhang and Wenxu Liu and Wentian Han and Huanhuan Yang and Jiming Liu and Jiangbin Zhang and Hui Li and Yao Liu}, doi = {10.1002/anie.202506252}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing the built-in electric field of thickness-insensitive small molecule cathode interlayers for high-efficiency and stable organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Operando magnetic resonance imaging for visualizing electrochemical triple-phase boundary. ANGEW, 64(31), e202506183. (www)

  @article{ , abstract = {The triple-phase boundary (TPB) is a complex interface where gas, liquid, and solid phases converge, crucially regulating the efficiency and performance of many electrochemical devices including fuel cells and batteries. However, conventional characterization techniques struggle to capture the dynamic processes and flooding at TPB. To address this, we develop operando electrochemical magnetic resonance imaging (EC-MRI), an inherently non-invasive technique sensitive to 1 H, which probes both bulk and boundary regions, enabling real-time visualization of TPB evolution and a deeper understanding of its function at the device level under operational conditions. In a study of proton exchange membrane fuel cell (PEMFC), with a focus on the kinetically sluggish O 2 reduction reaction in the cathode, operando EC-MRI quantitatively illustrates the interplay between power output, water content, and TPB evolution. It reveals that the TPB maps undergo significant spatial and dynamic variations, with TPB deterioration, rather than apparent water accumulation, directly triggering flooding, as proved using catalysts with different water generation and adsorption capabilities. Our finding opens new perspectives on water management and TPB design, with potential applications in other critical electrochemical processes such as H 2 oxidation, CO 2 reduction, and N 2 reduction, underscoring the value of operando EC-MRI for real-time diagnostics of electrochemical devices.}, archive = {J_ANGEW}, author = {Wen-Long Jiang and Shuo-Hui Cao and Chun-Yu Qiu and Hui-Jun Sun and Li-Na Wang and Jun-Bo Sheng and Li-Fei Ji and Shuo Liu and Zu-Rong Ni and Shu-Hu Yin and Xiao-Ping Zhang and Yan-Xia Jiang and Yu-Cheng Wang and Zhi-You Zhou and Zhong Chen and Shi-Gang Sun}, doi = {10.1002/anie.202506183}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Operando magnetic resonance imaging for visualizing electrochemical triple-phase boundary}, volume = {64}, year = {2025}, }
• (2025). Dual enzyme-responsive polymer-drug conjugates induce diverse cells mutual transcytosis to achieve deep pancreatic tumor penetration. ANGEW, 64(31), e202506038. (www)

  @article{ , abstract = {Enzyme-responsive active transporting nanomedicines have shown promise in overcoming the tumor-dense extracellular matrix barrier by inducing cancer cells’ intercellular transcytosis to deliver drugs deep into solid tumors. However, nanomedicine only responsive to the cancer cell-related enzyme is not very effective in pancreatic tumors because successive transcytosis cannot be established among the cancer cells, which are scattered in a large number of cancer-associated fibroblasts (CAFs). Here are reported dual-enzyme-responsive 7-ethyl-10-hydroxycamptothecin (SN38)-polymer conjugates capable of inducing transcytosis among cancer cells and CAFs to infiltrate pancreatic tumors efficiently. The conjugates are zwitterionic for long blood circulation. Once in the tumor, the γ-glutamyl transpeptidase (GGT) overexpressed on the tumor endothelial and cancer cells, or the fibroblast-activated protease (FAP) on CAFs, can cleave the γ-glutamylamide or the prolylglycine dipeptide amides, producing primary amines. The cationized conjugate then induces transcytosis among cancer cells and CAFs, establishing successive intercellular transport to infiltrate the tumor. The conjugates' enzyme reactivity and overall hydrophobicity determine their cationization and transcytosis behaviors. The conjugates with high hydrophobicity and fast cationization show potent antitumor activity in pancreatic cancer patient-derived xenograft and orthotopic tumor models. This study provides an active transportation strategy to overcome the delivery barrier of tumors with rich stroma cells.}, archive = {J_ANGEW}, author = {Rui Sun and Yifan Zhang and Ying Piao and Jiajia Xiang and Shiqun Shao and Quan Zhou and Jianbin Tang and Chengyuan Dong and Zhuxian Zhou and Youqing Shen}, doi = {10.1002/anie.202506038}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506038}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual enzyme-responsive polymer-drug conjugates induce diverse cells mutual transcytosis to achieve deep pancreatic tumor penetration}, volume = {64}, year = {2025}, }
• (2025). Covalent organic frameworks coupled with redox center and adsorption site for efficient shuttle-free zn-iodine batteries. ANGEW, 64(31), e202506006. (www)

  @article{ , abstract = {Aqueous zinc-iodine (Zn-I 2 ) batteries exhibit significant potential for next-generation energy storage system, but the polyiodide shuttle effect severely impairs their performance and stability. Herein, a series of woven covalent organic frameworks (COFs), namely COF-RuNCS-X (X = 1–6), with pre-designed ruthenium(II) redox center and sulfur adsorption sites were constructed for shuttle-free cathode material in Zn-I 2 batteries. The porous COF-RuNCS-X with abundant sulfur adsorption sites showed a selective adsorption of I 3 − species for effectively mitigating the shuttle effect. Meanwhile, the incorporation of ruthenium(II) center into the COFs skeleton enhanced the redox kinetics of iodine species. Remarkably, COF-RuNCS-6 featuring the large pore size and high degree of conjugation demonstrated a discharge specific capacity as high as 395.8 mAh g −1 in Zn-I 2 batteries and exhibited cycle stability up to 5000 cycles. This work provides a new understanding of the design of COF-based materials as efficient shuttle-free cathode materials for Zn-I 2 batteries.}, archive = {J_ANGEW}, author = {Jing-Dong Feng and Wang-Kang Han and Jun-Jun He and Yong Liu and Ruo-Meng Zhu and Jinfang Zhang and Huan Pang and Zhi-Guo Gu}, doi = {10.1002/anie.202506006}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202506006}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent organic frameworks coupled with redox center and adsorption site for efficient shuttle-free zn-iodine batteries}, volume = {64}, year = {2025}, }
• (2025). Machine learning-augmented molecular dynamics simulations (MD) reveal insights into the disconnect between affinity and activation of ZTP riboswitch ligands. ANGEW, 64(31), e202505971. (www)

  @article{ , abstract = {The challenge of targeting RNA with small molecules necessitates a better understanding of RNA–ligand interaction mechanisms. However, the dynamic nature of nucleic acids, their ligand-induced stabilization, and how conformational changes influence gene expression pose significant difficulties for experimental investigation. This work employs a combination of computational and experimental methods to address these challenges. By integrating structure-informed design, crystallography, and machine learning-augmented all-atom molecular dynamics simulations (MD), we synthesized, biophysically and biochemically characterized, and studied the dissociation of a library of small molecule activators of the 5-aminoimidazole–4–carboxamide ribonucleotide triphosphate (ZTP) riboswitch, a ligand-binding RNA motif that regulates bacterial gene expression. We uncovered key interaction mechanisms, revealing valuable insights into the role of ligand binding kinetics on riboswitch activation. Further, we established that ligand on-rates determine activation potency as opposed to binding affinity and elucidated RNA structural differences, which provide mechanistic insights into the interplay of RNA structure on riboswitch activation.}, archive = {J_ANGEW}, author = {Christopher R. Fullenkamp and Shams Mehdi and Christopher P. Jones and Logan Tenney and Patricio Pichling and Peri R. Prestwood and Adrian R. Ferré-D'Amaré and Pratyush Tiwary and John S. Schneekloth}, doi = {10.1002/anie.202505971}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505971}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning-augmented molecular dynamics simulations (MD) reveal insights into the disconnect between affinity and activation of ZTP riboswitch ligands}, volume = {64}, year = {2025}, }
• (2025). Systematic evaluation of polarizing agents for dynamic nuclear polarization enhanced NMR. ANGEW, 64(31), e202505944. (www)

  @article{ , abstract = {Dynamic nuclear polarization (DNP) can significantly enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy, via the transfer of polarization from unpaired electrons to nuclei. As a result, there is considerable interest in improving DNP efficiency, particularly through the development of new polarizing agents (PAs). Here, a series of 32 PAs, including 26 dinitroxide and 6 hetero biradicals, of which 11 are introduced for the first time, were evaluated for their performance in DNP NMR experiments at magnetic field strengths of 9.4 T, 14.1 T, and 21.1 T. The PAs that are soluble in aqueous media were compared for different proton concentrations. A detailed comparison of the enhancement factors, polarization build-up times, contribution factors, and the resulting overall sensitivity factors is provided. We find that the class of narrow-line-broad-line biradicals not only yield the best performance at high field (21.1 T and 14.1 T) but remain among the best at intermediate fields (9.4 T). Specifically, SNAPol-1 and HyTEK2 are consistently among the best performing radicals at any field. Among the dinitroxides, notably at 9.4 T, the AsymPol-POK and M-TinyPol families stand out in proton-dense aqueous matrices, and a newly developed dinitroxide, NaphPolCbo, is found to provide the best overall sensitivity factor in organic solvent.}, archive = {J_ANGEW}, author = {Ran Wei and Gilles Casano and Yuxuan Zhang and Ivanska M. Gierbolini-Colón and Yu Rao and Shubha S. Gunaga and Faith J. Scott and Jiaxin Zhou and Satyaki Chatterjee and Sanyog Kumari and Hakim Karoui and Mang Huang and Snorri Th. Sigurdsson and Gaël De Paëpe and Yangping Liu and Frédéric Mentink-Vigier and Amrit Venkatesh and Olivier Ouari and Lyndon Emsley}, doi = {10.1002/anie.202505944}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505944}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Systematic evaluation of polarizing agents for dynamic nuclear polarization enhanced NMR}, volume = {64}, year = {2025}, }
• (2025). Unlocking a ferrocenium superoxidizer with the perfluorinated cp* ligand. ANGEW, 64(31), e202505783. (www)

  @article{ , abstract = {The photolytically induced arene displacement of [Fe(C 5 H 5 )( o DCB)][PF 6 ] (oDCB = ortho -dichlorobenzene) in the presence of [NEt 4 ][C 5 (CF 3 ) 5 ] afforded the highly fluorinated and benchstable ferrocene [Fe(C 5 H 5 )(C 5 (CF 3 ) 5 )]. The perfluorinated Cp* ligand exerts an extreme electron withdrawing effect on the ferrocene with E 1/2 = 1.35 V (versus Fc/Fc + ). This proved to be the highest value obtained for any ferrocene reported so far. The corresponding stable and storable ferrocenium complex [Fe(C 5 H 5 )(C 5 (CF 3 ) 5 )][AsF 6 ] was generated in quantitative yield and represents not only the most oxidizing ferrocenium species, but also the strongest known isolable organometallic oxidizer. Its strength was demonstrated by the twofold oxidation of [Fe(C 5 (CH 3 ) 5 ) 2 ] to its dication and an oxidative C-H activation of ortho -terphenyl. This unprecedented redox chemistry combined with perfluorocarbon solubility allows for selective and quantitative recycling of the highly fluorinated ferrocene. Together with the low basicity and inertness of [Fe(C 5 H 5 )(C 5 (CF 3 ) 5 )], the chemistry of strong oxidizers is herein expanded into organometallics.}, archive = {J_ANGEW}, author = {Robin Sievers and Nico G. Kub and Tim-Niclas Streit and Marc Reimann and Günther Thiele and Martin Kaupp and Moritz Malischewski}, doi = {10.1002/anie.202505783}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505783}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking a ferrocenium superoxidizer with the perfluorinated cp* ligand}, volume = {64}, year = {2025}, }
• (2025). Self-healing indium sulfide catalyst for efficient and robust electrocatalytic CO2 conversion. ANGEW, 64(31), e202505587. (www)

  @article{ , abstract = {The reduction–reconstruction of the catalyst under negative bias has been identified as a significant rationale underlying the performance degradation of the electrocatalytic CO 2 reduction reaction (CO 2 RR). Screening catalysts with stable phases and robust crystal structures appears to be a feasible approach to counteract the reduction corrosion. In this work, with the guidance of computational predictions, a tetragonal phase In 2 S 3 electrocatalyst is designed through a self-healing strategy for the conversion of CO 2 to formate. Remarkably, In 2 S 3 exhibits superior stability for over 200 h at a current density of ∼210 mA cm −2 , with a persistent formate faradaic efficiency of ∼97%. A series of in situ spectroscopic measurements confirm that In 2 S 3 maintains the structural and valence state integrity throughout the reaction. Combined with density functional theory calculations, the performance enhancement mechanism and self-healing principle of In 2 S 3 are clearly elucidated. This work provides a novel perspective for the design of highly efficient and stable CO 2 RR electrocatalysts.}, archive = {J_ANGEW}, author = {Haiyan Wu and Yansong Zhou and Dongyu Han and Zhitong Wang and Shuyu Zhang and Jing Li and Peilin Deng and Daoxiong Wu and Xinlong Tian}, doi = {10.1002/anie.202505587}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505587}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-healing indium sulfide catalyst for efficient and robust electrocatalytic CO2 conversion}, volume = {64}, year = {2025}, }
• (2025). Light-responsive DNA droplets for controlling enzyme cascade pathways by dynamic phase separation. ANGEW, 64(31), e202505316. (www)

  @article{ , abstract = {Precise control of enzymatic cascade pathways is essential for deepening our understanding of metabolic processes and designing synthetic biochemical systems. In this study, we present a novel approach to modulate these cascades using light-responsive DNA droplets. Y-motif sequences with azobenzene-modified sticky ends (SE) were designed to form DNA droplets via liquid–liquid phase separation. These droplets enable selective sequestration of enzymes within compartments, allowing dynamic regulation of enzymatic cascades in response to ultraviolet (UV) and visible (vis) light stimuli. As a model system, we employed an incompatible enzymatic cascade, involving glucose oxidase (GOx), horseradish peroxidase (HRP), and catalase (CAT). Under visible light, the DNA droplets co-localize enzymes within the compartments, effectively regulating metabolic flux without altering the total enzyme concentration. Upon UV exposure, the droplets disassemble, releasing the sequestered enzymes and altering cascade dynamics. The versatility of this approach was further demonstrated using an alternative enzymatic cascade system comprising galactose oxidase (GAO), myeloperoxidase (MPO), and CAT. This system demonstrates that light-responsive DNA droplets are a powerful tool for regulating enzymatic pathways, with potential applications in synthetic biology, microreactor design, and bioengineering.}, archive = {J_ANGEW}, author = {Shaohong Zhou and Xiuqin Ju and Hui Chen and Yanwen Zhang and Jing Zheng and Kemin Wang and Xiaohai Yang and Jianbo Liu}, doi = {10.1002/anie.202505316}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505316}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-responsive DNA droplets for controlling enzyme cascade pathways by dynamic phase separation}, volume = {64}, year = {2025}, }
• (2025). Interfacing B-DNA and DNA mimic foldamers. ANGEW, 64(31), e202505273. (www)

  @article{ , abstract = {A linker unit was designed and synthesized that can serve both as a hairpin turn in a DNA duplex and anchor point for an aromatic helical foldamer mimicking the shape and surface properties of B-DNA. Methods were developed to synthesize natural/non-natural chimeric molecules combining foldamer and DNA segments. The ability of the linker to position the foldamer helix and the duplex DNA so that their rims and grooves are in register, despite their completely different chemical nature, was demonstrated using single crystal X-ray diffraction, circular dichroism and molecular models. Bio-layer interferometry confirmed that artificial hairpin DNA duplexes keep their ability to bind to DNA binding proteins. The chimeric molecules may pave the way to competitive inhibitors of protein-DNA interactions involving sequence-selective DNA-binding proteins.}, archive = {J_ANGEW}, author = {Manuel Loos and Felix Xu and Pradeep K. Mandal and Tulika Chakrabortty and Céline Douat and David B. Konrad and Melis Cabbar and Johannes Singer and Valentina Corvaglia and Thomas Carell and Ivan Huc}, doi = {10.1002/anie.202505273}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505273}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacing B-DNA and DNA mimic foldamers}, volume = {64}, year = {2025}, }
• (2025). Location-differentiated DNA hierarchical cyclic construction demarcating identical biomolecules across cell membrane microenvironments. ANGEW, 64(31), e202505249. (www)

  @article{ , abstract = {Local molecular composition across cell membrane microenvironments exerts profound effects on cellular physiology and pathology. Yet spatial demarcation of identical biomolecules inside and outside lipid raft microdomains has not been determined. Here we report location-differentiated DNA hierarchical cyclic construction for lipid raft-differentiated spatial profiling of identical biomolecules in living cells. It contains two sequential DNA cyclic construction reactions: primary one triggered by total target molecules and secondary one activated by lipid raft's location markers proximal to target molecules. Using this method, we differentially visualize identical biomolecules localized in lipid raft and non-lipid raft microdomains with different signals. We demonstrate the robustness and universality of this method by testing cell surface RNAs and proteins in diverse cell types. We reveal their diverse spatial demarcation with intrinsic heterogeneity. In both lipid raft-disrupting cells and senescent cells, MUC1 protein is dynamically organized between these two microdomains. Our strategy provides a promising avenue to investigate physiological and pathological functions of dynamic molecular compositions across cellular microenvironments.}, archive = {J_ANGEW}, author = {Zhu Li and Xinyin Li and Mengying Ye and Wenjing Shu and Yan He and Haotian Li and Feng Chen and Yongxi Zhao}, doi = {10.1002/anie.202505249}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505249}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Location-differentiated DNA hierarchical cyclic construction demarcating identical biomolecules across cell membrane microenvironments}, volume = {64}, year = {2025}, }
• (2025). Blue-to-green fine-tunable narrowband delayed fluorescence in peripherally dendritic modified bis-indolocarbazoles. ANGEW, 64(31), e202505191. (www)

  @article{ , abstract = {Highly efficient narrowband organic luminophores offer immense potentials for organic light-emitting diodes (OLEDs) with high color purity of electroluminescence (EL). Appropriately controlling their structural relaxation and vibronic couplings between the excited and ground states enables the desired narrowband emissions. Herein, based on a design concept featuring dendritic modifications, we demonstrate the exquisite color tuning of narrowband emissions from deep blue to green in non-boron ubiquitous molecular systems. By attaching two or four arylamine-based dendritic units to the periphery of the indolo[3,2,1- jk ]indolo[1′,2′,3′:1,7]indolo[3,2-b]carbazole ( BICz ) core, BICz-1.5G , BICz-2G , and BICz-2GII were developed as deep-blue, sky-blue, and green narrowband emitters, respectively. Comprehensive photophysical and computational studies revealed that the dendritic modifications do not impair the inherent narrowband emission ability of BICz while enhancing its thermally activated delayed fluorescence properties. OLEDs incorporating BICz-1.5G and BICz-2GII demonstrated high-efficiency, high-color-purity blue and green EL, with maximum external quantum efficiencies as high as 24.0% and 28.5%, respectively, and CIE coordinates of (0.13, 0.10) and (0.21, 0.68). Our findings will contribute to expanding the search space for narrowband organic luminophores.}, archive = {J_ANGEW}, author = {Jun Hyeon Lee and Takumi Watanabe and Lars Hartmann and Takuma Yasuda}, doi = {10.1002/anie.202505191}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Blue-to-green fine-tunable narrowband delayed fluorescence in peripherally dendritic modified bis-indolocarbazoles}, volume = {64}, year = {2025}, }
• (2025). A shelf-stable reagent for photocatalytic radical pentafluorosulfanylation of styrene derivatives. ANGEW, 64(31), e202505146. (www)

  @article{ , abstract = {We have developed the first family of air- and moisture-stable pentafluorosulfanylation (SF₅) reagents. Although the SF₅ group is a bioisostere of the trifluoromethyl group (CF₃)—exhibiting even greater electronegativity and lipophilicity, attributes that have earned it the nickname “super trifluoromethyl group”—the development of shelf-stable, non-toxic, and easy-to-handle SF₅-incorporating reagents had remained elusive for over 70 years since its discovery. Our discovery enables the synthesis of per- and polyfluoroalkyl substances (PFAS)-free fluorinated compounds, offering significant advantages over traditional CF₃ analogs. These new reagents exhibit promising reactivity under photochemical conditions, efficiently facilitating the formation of novel SF₅-containing molecules. Moreover, our approach is compatible with the late-stage functionalization of complex molecules. Mechanistic studies have provided valuable insights into the underlying reaction pathways.}, archive = {J_ANGEW}, author = {Yi Yang and Lulu Han and Alexis Taponard and Lhoussain Khrouz and Christophe Bucher and Cyrille Monnereau and Maurice Médebielle and Anis Tlili}, doi = {10.1002/anie.202505146}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505146}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A shelf-stable reagent for photocatalytic radical pentafluorosulfanylation of styrene derivatives}, volume = {64}, year = {2025}, }
• (2025). Universal metal-exchange strategy for room temperature synthesis of single-atom nanozymes. ANGEW, 64(31), e202505123. (www)

  @article{ , abstract = {The high-temperature limitations of single-atom catalysts (SACs) synthesis, primarily thermal aggregation and low metal loadings, are overcome by a novel room-temperature metal-exchange strategy. We leverage the weak Zn─N coordination in high-loading Zn SACs (12.10 wt%, synthesized via controlled ZIF-8 pyrolysis) as a platform for the facile exchange with a broad range of metals (Mn, Fe, Co, Ni, Cu, Ru, Pt, up to 12.67 wt%) and the creation of multi-metallic species. This ambient-temperature approach significantly reduces aggregation, enhancing the exposure of catalytic active sites and delivering superior multi-enzyme-like activities (catalase, peroxidase, oxidase). Our work not only provides a scalable, low-temperature route to high-performance SACs but also reveals crucial insights into the stability of SACs under metal-ion conditions.}, archive = {J_ANGEW}, author = {Jie Zhang and Zezhong Huang and Bolong Xu and Qingyuan Wu and Zhijun Huang and Huiyu Liu}, doi = {10.1002/anie.202505123}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505123}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Universal metal-exchange strategy for room temperature synthesis of single-atom nanozymes}, volume = {64}, year = {2025}, }
• (2025). Complementary Hydrogen─Bonded functionalized mixed conducting terpolymers for high-performance n-type organic electrochemical transistors and healable inverters. ANGEW, 64(31), e202505011. (www)

  @article{ , abstract = {High-performing n-type organic electrochemical transistors (OECTs), crucial for integrated circuits in wearable bioelectronics, demand organic mixed ion-electron conductors (OMIECs) that exhibit efficient mixed conduction and biological functionality for practical applications. However, the development of self-healing OMIECs has not yet been achieved due to the lack of suitable synthetic strategies. Here, we present a design concept through incorporating dynamic cross-linked hydrogen-bonded in the polymer backbone for the first demonstration of self-healing polymeric mixed conductors, enabling high-performing OECTs and high gain, self-healing inverters. These devices exhibit a mixed conducting figure of merit µ C* of 118 F cm −1 V −1 s −1 , three times higher than the copolymer without hydrogen bond, along with simultaneously improved volumetric capacitance and electron mobility. These improvements are attributed to the unique microstructure created by hydrogen bond, which results in a closer π-π stacking distance within smaller crystalline domain sizes. Additionally, a cost-effective post-processing side chain removal method is proposed, which retains high performance in n-type OECTs. Remarkably, inverters based on the hydrogen-bonded terpolymer demonstrate high gain and self-healing capabilities through solvent vapor exposure and annealing treatment. Insights from these terpolymers emphasize the use of dynamic hydrogen bonds in the conjugated backbone to enhance performance and enable self-healing high-gain inverters, advancing wearable bioelectronics for practical applications.}, archive = {J_ANGEW}, author = {Junxin Chen and Jiayao Duan and Runxia Wang and Juntao Tan and Zhengke Li and Iain McCulloch and Wan Yue}, doi = {10.1002/anie.202505011}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202505011}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Complementary Hydrogen─Bonded functionalized mixed conducting terpolymers for high-performance n-type organic electrochemical transistors and healable inverters}, volume = {64}, year = {2025}, }
• (2025). Impeding thermal atomization enables synthesizing Fe2N cluster liganded single fe-atom catalyst for highly efficient oxygen reduction reaction. ANGEW, 64(31), e202504935. (www)

  @article{ , abstract = {Anchoring a ligand, such as a functional group or a cluster, on the active metal center is an effective strategy for regulating the electronic structure of single-atom catalysts (SACs). Herein, we present a nitridation-induced-clustering strategy to produce not only SAC Fe-N 4 in N-doped carbon nanorods, but also Fe 2 N cluster as a ligand anchored on the active Fe site (Fe 2 N nc /Fe 1 -N-C). Unlike the conventional iron atomization process, the reactive nitridation process can generate thermodynamically stable Fe 2 N intermediates by nitriding the initially formed iron oxide, thereby impeding subsequent thermal atomization to fabricate Fe 2 N nc /Fe 1 -N-C catalysts. Compared to the conventional SAC Fe 1 -N-C with Fe-N 4 active sites, the Fe 2 N nc /Fe 1 -N-C nanorods are more active for oxygen reduction reaction (ORR), yielding a record high half-wave potential of 0.957 V versus RHE in alkaline condition. The Fe 2 N nc /Fe 1 -N-C nanorods can be utilized as air-cathode catalysts for Zn-air batteries with a charge-discharge gap of only ∼0.658 V and outstanding cyclability up to 1000 h. Theoretical calculations show that the Fe 2 N nc ligands indeed modified the electronic structures of Fe-N 4 sites, leading to a lower adsorption energy for the ORR intermediate OH* and facilitating the desorption of OH* and thus higher activity for ORR.}, archive = {J_ANGEW}, author = {Fei-Xiang Ma and Xiongyi Liang and Zi-Hao Liu and Yidi Chen and Zheng-Qi Liu and Wei Zhang and Liang Zhen and Xiao Cheng Zeng and Cheng-Yan Xu}, doi = {10.1002/anie.202504935}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504935}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Impeding thermal atomization enables synthesizing Fe2N cluster liganded single fe-atom catalyst for highly efficient oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Branching-induced intermolecular repulsion effects drive stable and sustainable flow batteries on condensed nitroxyl radicals. ANGEW, 64(31), e202504932. (www)

  @article{ , abstract = {Aqueous organic redox flow batteries (AORFBs) play a critical role in scalable energy storage applications where safety, cost, and lifetime matter most. However, harnessing the organics with redox chemistry is plagued by major molecular engineering principles in reversible processes and transformations. Herein, breaking from the conventional linear substituent structures, we report a chain-branched dual-ammonium nitroxyl radicals derivative as a stable and flowable catholyte for AORFBs. Paired with a viologen anolyte, the AORFBs with condensed electrolytes deliver a high-capacity retention rate of 99.992%/cycle (99.85%/day) and a peak power density of 140.3 mW cm −2 . In situ ultraviolet-visible characterization and theoretical simulation elucidate that the branched dual-ammonium structure accelerates ∼40% of the binding energy barrier, thereby enhancing intermolecular electrostatic repulsion. This effect effectively inhibits side reactions triggered by nucleophilic attacks, particularly in condensed nitroxyl radicals, maintaining the structural stability of both radical and oxoammonium states as well as their reversible transformations. Our redox organic formulation offers a direction towards stable and high-energy density AORFBs that seamlessly integrate eco-friendliness, durability, and sustainability.}, archive = {J_ANGEW}, author = {Hao Fan and Ravivarma Mahalingam and Hongbin Li and Yimin Lv and Jiangxuan Song}, doi = {10.1002/anie.202504932}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Branching-induced intermolecular repulsion effects drive stable and sustainable flow batteries on condensed nitroxyl radicals}, volume = {64}, year = {2025}, }
• (2025). A monolithium monohydrogen porphyrin. ANGEW, 64(31), e202504928. (www)

  @article{ , abstract = {Porphyrins and their metal complexes play essential roles in biological and industrial processes, functioning as key components in catalysis, photodynamic therapy, and organic (opto-)electronic materials. Despite their significance, the intermediate states involved in metal incorporation into porphyrins remain poorly understood and are rarely observed as stable compounds. Here, we report the solvent-free synthesis of the first neutral alkali metal monohydrogen porphyrin, which was selectively obtained by reaction of lithium vapor with thin films of tetraphenylporphyrin (H 2 TPP) under ultrahigh vacuum (UHV) conditions. The resulting monolithium monohydrogen tetraphenylporphyrin (LiHTPP) exhibits remarkable thermal stability and can be sublimated under UHV at 485 K without disproportionation, enabling its isolation. LiHTPP reacts with additional lithium to form dilithium tetraphenylporphyrin (Li 2 TPP), as confirmed through product analysis and reaction monitoring via photoelectron spectroscopy and mass spectrometry. Complementary theoretical simulations provide deeper insight into the chemical structure of this non-planar complex and the energetics of its formation. This study advances the understanding of monohydrogen metalloporphyrins and their role in metalation pathways, introducing a novel synthetic route for stable intermediates. The study also underscores the potential of monohydrogen metalloporphyrins for developing catalysts and electronic materials with tunable properties.}, archive = {J_ANGEW}, author = {Maik Schöniger and Stefan R. Kachel and Jan Herritsch and J. Michael Gottfried}, doi = {10.1002/anie.202504928}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504928}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A monolithium monohydrogen porphyrin}, volume = {64}, year = {2025}, }
• (2025). Ferromagnetic ordering outperforms coordination effects in governing oxygen reduction catalysis on high-index nickel single crystals. ANGEW, 64(31), e202504869. (www)

  @article{ , abstract = {The role of surface spin configuration in spin-dependent catalytic reactions remains contentious, particularly when compared to the established dominance of coordination environments. Here, we resolve this debate by systematically probing oxygen reduction reaction (ORR) mechanisms on high-index Ni single-crystal facets ([210], [310], [520]) through integrated density functional theory (DFT) and experimental studies. Contrary to conventional d-band center predictions, we demonstrate that ferromagnetic ordering fundamentally dictates catalytic activity by stabilizing triplet O 2 adsorption and lowering spin-forbidden transition barriers. The Ni (210) facet exhibits superior ORR performance (half-wave potential: 0.842 V vs. RHE), outperforming Ni (310) and Ni (520) due to its optimized d-band center and enhanced saturation magnetization. External magnetic fields amplify this effect, yielding a 28% current density enhancement for Ni (210)—nearly triple that of Ni (520). Spin-polarized DFT calculations reveal that ferromagnetic ordering reduces the potential-determining step energy barrier for *OH desorption by 7.0%, overriding coordination-number effects. These findings establish ferromagnetic alignment as a critical design criterion for spin-engineered electrocatalysts, offering a paradigm shift from coordination-centric optimization to spin-polarized interface engineering.}, archive = {J_ANGEW}, author = {Menglong Sun and Jiabin Chen and Zhibin Zhang and Yuan Jing and Mengze Zhao and Lili Chen and Kaihui Liu and Chuang Zhang and Xi Wang and Jiannian Yao}, doi = {10.1002/anie.202504869}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ferromagnetic ordering outperforms coordination effects in governing oxygen reduction catalysis on high-index nickel single crystals}, volume = {64}, year = {2025}, }
• (2025). Efficient bicarbonate electrolysis to formate enabled via ionomer surface modification in cation exchange membrane electrolyzers. ANGEW, 64(31), e202504835. (www)

  @article{ , abstract = {Electrochemical CO 2 reduction (CO 2 RR) is a promising method for converting CO 2 into valuable chemicals, with formate being a particularly viable product. However, current gas-fed CO 2 RR systems rely on highly pure CO 2 feed gases and are incompatible with point-source CO 2 emissions without prior capture and concentration. Bicarbonate electrolysis offers a potential solution by bridging the gap between CO 2 emissions and utilization. However, existing electrolyzer configurations, especially those using bipolar membranes (BPM), require high working voltages and suffer from poor energy efficiency. Here, we present a cation exchange membrane (CEM)-based membrane electrode assembly (MEA) incorporating a surface-modified bismuth cathode catalyst. The success of this approach is attributed to two key factors: the use of the positively charged ionomer PiperION for surface modification, which creates a favorable cathode microenvironment; the single CEM that enhances proton flux from the anode to the cathode while reducing ionic impedance. The CEM-based MEA demonstrates a formate faradaic efficiency of up to 80%, with a significant 1.5 V reduction in operating voltage compared to BPM-based MEAs at 300 mA cm −2 . Additionally, the CEM-based MEA exhibits excellent tolerance to O 2 impurities and maintains high performance even with simulated flue gas, making it suitable for direct CO 2 utilization from point sources.}, archive = {J_ANGEW}, author = {Kewen Xing and Mengjing Wang and Binbin Pan and Chenglin Liang and Yanguang Li}, doi = {10.1002/anie.202504835}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504835}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient bicarbonate electrolysis to formate enabled via ionomer surface modification in cation exchange membrane electrolyzers}, volume = {64}, year = {2025}, }
• (2025). Steric-dominated intermediate stabilization by organic cations enables highly selective CO2 electroreduction. ANGEW, 64(31), e202504785. (www)

  @article{ , abstract = {Precisely modulating the binding energies of intermediates through cationic engineering remains a pivotal challenge in controlling reaction pathways and improving selectivity for electrocatalytic CO 2 reduction reaction (CO 2 RR). Although alkali cations are widely recognized as stabilizing intermediates via electrostatic interactions, this study proposes a steric-effect-dominated strategy using organic quaternary ammonium cations (C n TA + ) to flexibly tune the adsorption of intermediates. Through in-situ attenuated total reflectance-surface enhanced infrared absorption spectroscopy (ATR-SEIRAS), we elucidate that C n TA + cations with longer alkyl chains substitute K + more efficiently within the electrical double layer, exhibiting higher affinity for the Cu surface. This steric dominance significantly enhances the adsorption of key intermediates, steering the pathway toward formic acid (HCOOH) production. An improved Faradaic efficiency (FE) up to 90% for HCOOH was achieved using octadecyl trimethyl ammonium (C 18 TA + ) cations. This molecular engineering strategy provides a route to flexibly tune the adsorption of intermediates to improve the performance of CO 2 RR.}, archive = {J_ANGEW}, author = {Zishan Han and Xinyu Wang and Zhiguo Li and Jiachen Gao and Zheng Hu and Yaogang Wang and Siqi Li and Xuejiao Mao and Quan-hong Yang and Zhe Weng}, doi = {10.1002/anie.202504785}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504785}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Steric-dominated intermediate stabilization by organic cations enables highly selective CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Ether-oxygen groups modified carboxylic ester enabling high-voltage lithium metal batteries. ANGEW, 64(31), e202504490. (www)

  @article{ , abstract = {Lithium metal batteries (LMBs) operating at high cut-off voltages can achieve an energy density exceeding 500 Wh kg −1 ; however, they often suffer from severe capacity degradation due to electrolyte decomposition. Herein, propylene glycol monomethyl ether acetate (PMA) is introduced as a novel solvent for LMB electrolytes. The unique ether-oxygen functionality in PMA exhibits high steric hindrance, leading to weak lithium-ion coordination, which promotes the formation of contact ion pairs (CIPs) in the electrolyte solvation structure, especially in the presence of dual salts. A Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811) battery employing the formulated PMA-based electrolyte demonstrates stable cycling at a high cut-off voltage of 4.5 V for over 100 cycles, retaining 90.1% of its initial capacity even at 60 °C. Furthermore, a molecular interfacial model is proposed to elucidate the impact of the designed electrolyte on electrode interfacial behavior and battery performance, providing valuable insights for the development of high-performance LMB electrolytes.}, archive = {J_ANGEW}, author = {Shuang Li and Hongliang Xie and Pushpendra Kumar and Yinghua Chen and Jia Wang and Akang Huang and Wandi Wahyudi and Hui Zhu and Jiao Yin and Qian Li and Zheng Ma and Jun Ming}, doi = {10.1002/anie.202504490}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504490}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ether-oxygen groups modified carboxylic ester enabling high-voltage lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Thiotemplated polyketide chain fusion and reductive cyclization build the reactive butenolide core of malleicyprol. ANGEW, 64(31), e202504485. (www)

  @article{ , abstract = {Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, features a molecular cyclopropanol warhead linked to a reactive butenolide core. Biosynthetic considerations suggested that this heterocycle was formed by the merger of two individual polyketide chains, but the precise mechanism has remained elusive. By combining chemical synthesis, complete in vitro reconstitution of the biotransformation, and mutational analysis, we show that two individually generated polyketide chains are joined by a noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF, which forms an ester bond. By mutagenesis, biochemical assays, and trapping of the aldehyde generated from a substrate surrogate, we found that the terminal reductase domain mediates a reductive chain release with concomitant ring formation. The feasibility of the proposed Knoevenagel-type intramolecular cyclization into the butenolide moiety was confirmed by a biomimetic synthesis of malleicyprol. The elucidation of the unprecedented thiotemplated butenolide biosynthesis by head-to-head fusion of two polyketide chains not only expands the synthetic biology toolbox but may also inspire the development of antivirulence strategies against BP pathogen infections.}, archive = {J_ANGEW}, author = {Jonas Fiedler and Leo Dumjahn and Mie Ishida-Ito and Felix Trottmann and Keishi Ishida and Christian Hertweck}, doi = {10.1002/anie.202504485}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504485}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thiotemplated polyketide chain fusion and reductive cyclization build the reactive butenolide core of malleicyprol}, volume = {64}, year = {2025}, }
• (2025). Splicing them together: Construction of Polyoxovanadate–Organic polyhedra-based pyrgoscages and catenanes. ANGEW, 64(31), e202504424. (www)

  @article{ , abstract = {Following the construction schemes of pyrgoscages and catenanes, attempts to splice polyoxovanadate-based metal–organic polyhedra (POV-MOPs) together have been carried out in this work. To meet the requirements of POV-MOPs with varied sizes, synthetic strategies including reconstruction of original vertex, introduction of exogenous vertex, and initiative of polyhedral interlock have been developed, which successfully integrated a pair of tetrahedral monomers into an hourglass-shaped dimer. On top of this, several structuring principles, such as anisotropic enhancement, electrostatic potential reduction, and sufficient intramolecular support, can be drawn from here and popularized to the related MOP systems. Thanks to the advent of such splicing techniques managed by both covalent and non-covalent interactions, the close communication of POV-MOPs has afforded not only the unprecedented structural archetypes, but the unique behaviors for NH 3 adsorption as well.}, archive = {J_ANGEW}, author = {Ke-Wei Tong and Yan-Hu Wang and Jing Du and Chao-Qin Chen and Ya-Qian Lan and Peng Yang}, doi = {10.1002/anie.202504424}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Splicing them together: Construction of Polyoxovanadate–Organic polyhedra-based pyrgoscages and catenanes}, volume = {64}, year = {2025}, }
• (2025). High-performance FeP catalyst for electrochemical ammonia production and recovery via joule-stripping. ANGEW, 64(31), e202504174. (www)

  @article{ , abstract = {The electrochemical reduction of nitrate (NO₃RR) offers a promising route for decentralized and sustainable ammonia production while addressing environmental challenges associated with nitrate pollution. However, the development of practical implementations has been slowed by the challenge of creating highly stable and selective catalysts for strongly basic environments, along with the difficulty of efficiently recovering ammonia from dilute solutions. Here, we introduce a partially oxidized amorphous iron-phosphide (POA-FeP) electrocatalyst that combines high activity and stability with an innovative Joule-stripping strategy for ammonia recovery. Electrodeposited onto nickel foam (NF), the POA-FeP catalyst achieves benchmark partial current densities of −720 mA cm −2 in neutral media and −932 mA cm −2 in alkaline media, and near quantitative Faradaic efficiencies (FE). The robustness of the POA-FeP/NF catalyst was highlighted by its ability to maintain FE above 90% during continuous operation for over 1000 h at a total current density of −300 mA cm −2 . We demonstrate that the Joule heating resulting from the operation of the electrolyzer at high current density can be exploited to induce the volatilization of ammonia, which can then be recovered as solid ammonium chloride with >95% yield. This integrated Joule-stripping approach simplifies ammonia recovery and opens up new possibilities for scalable and energy-efficient nitrate reduction systems.}, archive = {J_ANGEW}, author = {Yuan-Zi Xu and Robin N. Dürr and Florian Häfliger and Daniel F. Abbott and Victor Mougel}, doi = {10.1002/anie.202504174}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202504174}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance FeP catalyst for electrochemical ammonia production and recovery via joule-stripping}, volume = {64}, year = {2025}, }
• (2025). Harmonizing nanoparticle exsolution from Ce–Sm oxide matrix for stable methane dry reforming. ANGEW, 64(31), e202503997. (www)

  @article{ , abstract = {Catalyst deactivation hinders the application of high-temperature catalysis such as methane dry reforming, where nanoparticle exsolution will likely clear the path. However, the harsh reaction conditions often easily unbalance the exsolution degree, leading to either sintering or insufficient exsolution of metal nanoparticles. Here, we achieve the fabrication of highly dispersed yet exposed Rh nanoparticles exsolved from the Ce–Sm oxide matrix. Starting from examining the metal-support interaction of Rh–CeO 2 and Rh–Sm 2 O 3 , the exsolution dynamics of Rh nanoparticles are studied via multiple in situ techniques. Rapid exsolution from CeO 2 induces Rh sintering and catalytic deactivation, whereas sluggish exsolution from Sm 2 O 3 results in Rh encapsulation with poor activity. The balanced metal-support interaction harmonizes the exsolution of Rh nanoparticles from the Ce–Sm oxide matrix, fabricating an antisintering and coke-resistant catalyst for methane dry reforming. This work provides insights into the development of catalysts with structural robustness, where the essence lies in the engineering of nanoparticle exsolution.}, archive = {J_ANGEW}, author = {Yongjie Ye and Haofan Lei and Yuanbin Qin and Zhen Wang and Sunpei Hu and Tao Zhou and Lijun Zhang and Ruyang Wang and Zizhen Xiao and Xinhua Gao and Qingxiang Ma and Shucheng Shi and Hui Zhang and Han Yan and Shiming Zhou and Chao Ma and Zhi Liu and Jing Tao and Jie Zeng}, doi = {10.1002/anie.202503997}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202503997}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harmonizing nanoparticle exsolution from Ce–Sm oxide matrix for stable methane dry reforming}, volume = {64}, year = {2025}, }
• (2025). Is phenylnitrene a missing link in the formation of polycyclic aromatic nitrogen heterocycles?. ANGEW, 64(31), e202503940. (www)

  @article{ , abstract = {The incorporation of heteroatoms into the framework of polycyclic aromatic hydrocarbons (PAHs), in particular of nitrogen to yield polycyclic aromatic nitrogen heterocycles (PANHs), has been proposed for both astronomical and combustion environments, but no suitable precursors and pathways have been found. Analogous pathways to PAH formation are kinetically or energetically inhibited in the presence of a nitrogen heteroatom. We report on the reaction of phenylnitrene ( 3 PhN, c -C 6 H 5 N) with resonance-stabilized propargyl radicals (C 3 H 3 ) and find that the association reaction bifurcates depending on the orientation of the attacking propargyl radical and yields multiple isomeric products. Among them, we identify the condensed-ring quinoline and conclude that nitrenes are viable candidates to drive the formation of PANHs.}, archive = {J_ANGEW}, author = {Rahel Arns and Rory McClish and Patrick Hemberger and Andras Bodi and Jordy Bouwman and Tina Kasper and Domenik Schleier}, doi = {10.1002/anie.202503940}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202503940}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Is phenylnitrene a missing link in the formation of polycyclic aromatic nitrogen heterocycles?}, volume = {64}, year = {2025}, }
• (2025). Boron-activated single-metal-site catalysts break adsorption-energy scaling relations for robust bifunctional oxygen catalysis. ANGEW, 64(31), e202503936. (www)

  @article{ , abstract = {The electrocatalytic oxygen evolution and reduction reaction (OER/ORR) catalysts are paramount to many renewable energy technologies. Atomically-dispersed transition-metal catalysts are compelling alternatives to current dominant noble-metal catalysts, yet they often show inadequate activity for OER and insufficient durability in practical battery operations. Here, we show a rational methodology that enables single-metal-site catalyst to break universal adsorption-energy scaling limitations for both OER/ORR and push bifunctional catalytic performance of transition-metal-dominated catalysts to unprecedented level. Other than metal–nitrogen coordination, the newly-designed catalyst (namely metal-C-B) stabilizes atomic metals on B-doped carbon via metal–carbon coordination and afford favorable electronic engineering. The optimized Co-C-B catalyst in base exhibits a record-low OER overpotential of 172 mV at 10 mA cm −2 and a superior ORR half-wave potential of 0.87 V with robust stability over 500 h of continuous OER or ORR, which endows a rechargeable Zn–air battery with over 6755 charge/discharge cycles. The delivered mass activities of 33941 A g metal −1 for OER and 15873 A g metal −1 for ORR are respectively ∼112/80-fold higher than those of commercial noble-metal counterparts. Atomically-dispersed CoC 4 Bᵪ moieties were theoretically identified as unique bifunctional active centers, breaking usual scaling relations of intermediates adsorption and boosting inherent OER/ORR activities simultaneously beyond theoretical limitations for single metal site.}, archive = {J_ANGEW}, author = {Zhongke Yuan and Jing Li and Zhengsong Fang and Meijia Yang and Linfeng Zhong and Cong Liu and Jingyuan Ma and Zhiping Zeng and Dingshan Yu and Xudong Chen and Liming Dai}, doi = {10.1002/anie.202503936}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202503936}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boron-activated single-metal-site catalysts break adsorption-energy scaling relations for robust bifunctional oxygen catalysis}, volume = {64}, year = {2025}, }
• (2025). Mechanistic promiscuity in cobalt-mediated CO2 reduction reaction: One- versus two-electron reduction process. ANGEW, 64(31), e202503705. (www)

  @article{ , abstract = {We compare the carbon dioxide reduction (CO 2 RR) activity and selectivity of the complexes [ (Hbbpya)Co II ] 2+ and [ (Mebbpya)Co II ] 2+ , which contain two 2,2′-bipyridine chelating groups linked by -NH or -NCH 3 moieties, respectively. Whereas [ (Hbbpya)Co II ] 2+ forms CO under electrocatalytic conditions in presence of phenol (PhOH) with high selectivity, [ (Mebbpya)Co II ] 2+ shows higher hydrogen evolution reaction activity and low selectivity for CO production. The molecular origin of the difference in product selectivity was analysed based on spectroscopic trapping of reactive intermediates and detailed kinetic and theoretical studies. A difference in mechanism is evident; whereas an efficient proton relay mediated by the -NH group initiates a two-electron reduction of CO 2 in the case of [ (Hbbpya)Co II ] 2+ , one-electron chemistry prevails for [ (Mebbpya)Co II ] 2+ . Under stopped-flow conditions, we trapped the one-electron reduced CO 2 radical anion in [ (Mebbpya)Co I (CO 2 −• ) ], which forms oxalate under aprotic conditions. This study underlines the importance of subtle electronic and protonation changes in controlling the CO 2 RR product selectivity.}, archive = {J_ANGEW}, author = {Ayan Bera and Sarah Bimmermann and Philipp Gerschel and Dibya Jyoti Barman and Leon Gerndt and Thomas Lohmiller and Kaltum Abdiaziz and Alexander Schnegg and Maylis Orio and Dennis G. H. Hetterscheid and Kara L. Bren and Michael Roemelt and Ulf-Peter Apfel and Kallol Ray}, doi = {10.1002/anie.202503705}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202503705}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanistic promiscuity in cobalt-mediated CO2 reduction reaction: One- versus two-electron reduction process}, volume = {64}, year = {2025}, }
• (2025). Incorporation of dye-derived carbon dots into carbon nitride nanosheets for enhanced photoinduced atom transfer radical polymerization. ANGEW, 64(31), e202503391. (www)

  @article{ , abstract = {Carbon dots have made significant advancements in photoinduced atom transfer radical polymerization (photo-ATRP), achieving ultrafast reaction rates and precise control over the resulting polymers. However, their ultrasmall size necessitates time-consuming and resource-intensive purification steps, which can ultimately lead to undesirable product contamination. In this study, we integrated dye-derived carbon dots (NCD) into nitrogen-deficient carbon nitride (CN) nanosheets via a hydrothermal process, forming NCD@CN heterojunctions with an expanded delocalized heterocyclic structure, enhanced specific surface area, and improved light absorption. The chemical linkages between the two components created NCD@CN heterojunctions, which improved interfacial interactions and promoted efficient charge transfer. The NCD@CN heterojunctions demonstrated ultrahigh activity, comparable to the NCD precursors, achieving a turnover number up to 1780 and a turnover frequency up to 59.3 min −1 . This led to the production of polymers with tailor-made structures, predicted molecular weights, and narrow dispersities. Additionally, they enabled complete catalyst recovery across multiple polymerization cycles. The incorporation of NCD into CN nanosheets affords new territory for high-performance photocatalysts at the atomic level and provides alternative pathways for ultrafast photo-ATRP processes.}, archive = {J_ANGEW}, author = {He Yu Peng and Xue Li and Yang Li and Cong Ying Song and Jianfei Chen and Tao Cai}, doi = {10.1002/anie.202503391}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202503391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Incorporation of dye-derived carbon dots into carbon nitride nanosheets for enhanced photoinduced atom transfer radical polymerization}, volume = {64}, year = {2025}, }
• (2025). Methanol-facilitated cascaded polyolefin upcycling enabling the efficient generation of high-value c9+ alkylaromatics. ANGEW, 64(31), e202503355. (www)

  @article{ , abstract = {Existing polyolefin chemical recycling and upcycling strategies predominantly yield fuels, waxes, and olefins, which are characterized by relatively low economic value. Although attempts have been made to synthesize functionalized chemicals, a particularly promising product category—C 9 -C 12 polysubstituted alkylbenzenes with a market price exceeding 1400 USD per ton—remains largely overlooked. Herein, we present a novel methodology that utilizes methanol as a coreactant, with the goal of achieving high-yield synthesis of polysubstituted alkylbenzenes. Under mild reaction conditions (280 °C), the process attains a 97.8% conversion rate of low-density polyethylene (LDPE, M w = 300 kDa) and complete conversion of methanol. Based on the mass of polyethylene, it produces 37 wt% of aromatic products, accompanied by an 87% increase in the mass yield of C 9 –C 12 alkylbenzenes. Isotope-labeling experiments conducted with 13 CH 3 OH and in situ FTIR disclose that methanol acts synergistically to promote carbocation-mediated C─C bond cleavage and self-amplifying Friedel–Crafts alkylation reactions. This mechanism steers the methylative homologation pathway toward the formation of polymethylated aromatics. The versatility of this approach, which is applicable to a wide variety of polyolefins, holds the promise of opening new pathways for a profitable circular economy in the plastics industry.}, archive = {J_ANGEW}, author = {Zhuo Chen and Zetian Qiu and Siyu Lin and Bolin Lin}, doi = {10.1002/anie.202503355}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202503355}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Methanol-facilitated cascaded polyolefin upcycling enabling the efficient generation of high-value c9+ alkylaromatics}, volume = {64}, year = {2025}, }
• (2025). Label-free detection of virus-membrane interactions using surface-enhanced infrared absorption (SEIRA) spectroscopy. ANGEW, 64(31), e202502998. (www)

  @article{ , abstract = {Viral binding and membrane fusion are essential steps in viral infection, mediated by viral proteins that bind to host cell receptors and facilitate the fusion between viral and host membranes. Targeting these steps for the development of new antiviral strategies requires methods that enable investigating virus-membrane interactions under in-situ conditions, while providing mechanistic insights on a molecular level. Here, we demonstrate the use of surface-enhanced infrared absorption (SEIRA) spectroscopy combined with tethered bilayer lipid membranes (tBLMs) for the label-free detection of virus-membrane interactions, using the Influenza A/X-31 virus (IAV) as a model. Exploiting the nanometer-scale surface-sensitivity of SEIRA, we detect the vibrational fingerprint of IAV's hemagglutinin (HA) glycoprotein, as it specifically binds to sialic acid receptors of the ganglioside GD1a in the tBLM, mimicking the host membrane. Triggering viral fusion via a pH change, we identify structural changes of HA engaging with the host membrane model. Moreover, by constructing the tBLM from deuterated lipids, we utilize the vibrational isotope effect and distinguish between viral and model membrane, providing a basis to track lipid mixing. This approach establishes a powerful tool for spectroscopic studies of the function and inhibition of viral proteins, while still embedded in intact virus particles.}, archive = {J_ANGEW}, author = {Amelie Teresa Heinen and Saskia Heermant and Daniel Christian Lauster and Stephan Block and Jacek Kozuch}, doi = {10.1002/anie.202502998}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202502998}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Label-free detection of virus-membrane interactions using surface-enhanced infrared absorption (SEIRA) spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Dissected MACl involved reaction pathway for low temperature fabrication of high-efficiency flexible perovskite solar cells. ANGEW, 64(31), e202502949. (www)

  @article{ , abstract = {FAPbI 3 -based perovskite solar cells (PVSCs) are highly promising due to their excellent power conversion efficiency (PCE). However, the formation of stable α-FAPbI 3 requires annealing at a temperature of at least 150 °C, which can induce significant residual stress and make the process incompatible with plastic substrates, resulting in poor crystal quality and compromised mechanical properties. To address these issues, we present a novel approach using methylammonium chloride (MACl) vapor-assisted lead iodide (PbI 2 ) to form homogeneous intermediate phases (MAPbCl 3 and Pb 3 I 8 ). This method optimizes the reaction pathway; accordingly pure α-phase perovskite can be completely formed at 100 °C, contrasting with conventional MACl component engineering in organic amine salt solution. We have intensively deciphered the reaction pathway leading to intermediate phase formation, as well as the nucleation and phase transition processes into the photoactive perovskite at 100 °C. Additionally, we have conducted a comprehensive study on temperature-dependent residual stress and cation reaction competition, meanwhile extensively dissecting the competitive implication of interface mismatch and lattice defects leading to residual stress and cation component inhomogeneity. Consequently, the modified flexible-PVSCs have achieved a remarkable efficiency of 24.46% (25.50% for rigid PVSCs). The devices also exhibit significantly improved long-term and mechanical stability.}, archive = {J_ANGEW}, author = {Xiao Luo and Yang Zhong and Binlou Gao and Jiacheng He and Xueying Wang and Licheng Tan and Yiwang Chen}, doi = {10.1002/anie.202502949}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202502949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dissected MACl involved reaction pathway for low temperature fabrication of high-efficiency flexible perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). All iron-group and platinum-group elements metal high-entropy alloy nanoparticles. ANGEW, 64(31), e202502552. (www)

  @article{ , abstract = {High-entropy alloys (HEA) are promising catalyst materials for important energy transformations. So far, the focus has been on platinum-group metals, which possess excellent catalytic performance and similar properties, thus being easy to synthesize. However, incorporating more abundant and cheaper elements is preferable for large-scale applications and is fundamentally more interesting, as elements with different properties are expected to greatly affect the structural and electronic characteristics of the resulting alloy. Unfortunately, significant differences in elemental properties greatly complicate the synthesis and require extreme reaction conditions. In this work, we demonstrate the first synthesis of high-entropy alloy nanoparticles containing the nine neighboring elements used most often in heterogeneous catalysis: all the iron-group metals (Fe, Co, and Ni) and all the platinum-group metals (Ru, Rh, Pd, Os, Ir, and Pt) through a simple low-temperature solution process. Remarkably, alloying the iron-group base metals with the platinum-group metals results in 30% increase in the catalytic activity for the hydrogen evolution reaction (HER) under acidic conditions (TOF@25 mV = 1.58 s −1 ) compared to the equivalent alloy containing only platinum-group metals conditions (TOF@25 mV = 1.2 s −1 ). This activity is three times that of a commercial Pt/C catalyst (TOF@25 mV = 0.58 s −1 ), demonstrating simultaneous reduction in precious metal content and performance enhancement of electrocatalysts.}, archive = {J_ANGEW}, author = {Julien Mahin and Kohei Kusada and Megumi Mukoyoshi and Tomokazu Yamamoto and Takaaki Toriyama and Yasukazu Murakami and Osami Sakata and Shogo Kawaguchi and Hirotaka Ashitani and Yoshiki Kubota and Hiroshi Kitagawa}, doi = {10.1002/anie.202502552}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202502552}, shortjournal = {Angew. Chem. Int. Edit.}, title = {All iron-group and platinum-group elements metal high-entropy alloy nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Room-temperature material Recycling/Upcycling of polyamide waste enabled by cosolvent-tunable dissolution kinetics. ANGEW, 64(31), e202502474. (www)

  @article{ , abstract = {Polyamides (PAs, nylons) are a ubiquitous class of high-performance plastics used extensively in a wide range of applications. Their high resistance to many common solvents and tendency to hydrolyze in strong acids or bases creates a major hurdle to low-emissions material recycling (i.e., resource separation and recovery). In the present study, the first detailed investigation into the molecular mechanisms of polyamide dissolution, we show that introducing a weakly hydrogen-bonding cosolvent into formic acid can effectively tune the solvent–solvent and solvent–polymer interactions, drastically accelerates the room-temperature dissolution kinetics of common (short-chain) polyamides such as PA6 and PA66, as well as long-chain and semi-aromatic varieties. The recovered polymers show no change in their chemical structures or properties, and sufficient selectivity allows for fillers such as short and long fibers, inorganic nanoparticles, metals, and other mixed polymer phases to be recovered at high efficiency (>95%) along with recirculation of all solvents (>98%). This cosolvent-enabled approach has the potential to make polyamide recycling more sustainable and economical by reducing the energy input and CO 2 emissions required to separate and recover the various constituent materials from automotive and electrical components, textiles, and beyond.}, archive = {J_ANGEW}, author = {Jonathon Tanks and Kenji Tamura}, doi = {10.1002/anie.202502474}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202502474}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Room-temperature material Recycling/Upcycling of polyamide waste enabled by cosolvent-tunable dissolution kinetics}, volume = {64}, year = {2025}, }
• (2025). Self-promoting targeted delivery of epigenetic immunostimulants to activate breast cancer immunity via HDACs downregulation and PD-l1 upregulation. ANGEW, 64(31), e202502120. (www)

  @article{ , abstract = {The low immunogenicity and immunosuppressive phenotype of breast cancer significantly limit the effectiveness of immunotherapy. This study reveals that histone deacetylases (HDACs) are upregulated in breast cancer, while lower levels of HDACs and higher levels of programmed cell death ligand 1 (PD-L1) are associated with better patient prognosis. Moreover, Trichostatin A (TSA) is confirmed to suppress HDACs and increase PD-L1 expression. Building on these insights, a self-promoting targeted immunostimulant (SPT-IS) is developed to activate breast cancer immunity by epigenetically upregulating PD-L1. SPT-IS can selectively accumulate in PD-L1-overexpressing breast cancer cells for co-delivery of Chlorin e6 (Ce6) and TSA. Notably, SPT-IS-induced epigenetic upregulation of PD-L1 creates a self-promoting tumor-targeting loop that enhances drug delivery efficiency. Besides, SPT-IS generates reactive oxygen species (ROS) to kill tumor cells and release damage-associated molecular patterns, increasing tumor immunogenicity. Additionally, the epigenetic regulation ability of SPT-IS upregulates immunomodulatory cytokines and stimulates T cell cytotoxicity for immune activation. Immunological results confirm robust immunomodulatory effects of SPT-IS, significantly enhancing tumor-infiltrating lymphocytes recruitment and proliferation, leading to notable anti-tumor efficacy. These findings highlight the potential of a self-promoting targeted strategy to enhance drug delivery and provide an epigenetic approach to boost the immune response against breast cancer.}, archive = {J_ANGEW}, author = {Xiayun Chen and Lichong Lu and Ziqi Liang and Baixue Yu and Zhouchuan Shao and Jianqiao Li and Yi Cen and Yibin Liu and Shiying Li and Xiaoyuan Chen}, doi = {10.1002/anie.202502120}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202502120}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-promoting targeted delivery of epigenetic immunostimulants to activate breast cancer immunity via HDACs downregulation and PD-l1 upregulation}, volume = {64}, year = {2025}, }
• (2025). Simple and rapid tumor EV enrichment enabled by long DNA probe-guided entanglement. ANGEW, 64(31), e202501804. (www)

  @article{ , abstract = {Specific subpopulations of extracellular vesicles (EVs) hold significant clinical potential for biomarker discovery, disease diagnosis, and therapeutic agents. However, this field remains underutilized due to the lack of straightforward and versatile techniques for isolating EV subpopulations from biofluids. Here, we present LODGE, a lo ng D NA probe- g uided EV e ntanglement strategy for the simple, rapid, and selective enrichment of tumor-derived EVs (tEVs) from clinical specimens. LODGE uses two long DNA affinity probes to recognize specific subpopulations, causing them to aggregate with the assistance of splint strands, thereby achieving nondestructive, high-yield, and high-purity separation of tEVs within a short period. Proteomic analysis revealed that the isolated tEVs contributed to the identification of tumor-associated biomarkers compared to total EVs. Additionally, by incorporating a split G-quadruplex-containing molecular trap domain, a novel structure that significantly improves the fluorescence emission of thioflavin T (ThT), into DNA affinity probes, we developed an innovative LODGE-ThT sensing strategy for the highly sensitive profiling of multiple tEV subpopulations. Using data from the tEVs alongside clinical indicators processed with machine learning algorithms, we effectively classified five tumor types. Our results show that LODGE is a promising tool for identifying specific EV subpopulations, and fostering their biomedical applications.}, archive = {J_ANGEW}, author = {Yuanjie Liu and Yunpeng Fan and Xiaoqiang Li and Gang Tian and Bo Shen and Menghan Li and Kai Su and Xuhuai Fu and Mengxuan Zhang and Yonghong Wang and Xinyu Li and Xinmin Li and Shijia Ding}, doi = {10.1002/anie.202501804}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202501804}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simple and rapid tumor EV enrichment enabled by long DNA probe-guided entanglement}, volume = {64}, year = {2025}, }
• (2025). Cu2O nano-homojunction for high-efficiency electrocatalytic CO2-to-ethylene conversion. ANGEW, 64(31), e202501554. (www)

  @article{ , abstract = {The efficient electrochemical CO 2 reduction into value-added multi-carbon products is of great importance and remains challenging. Here, we demonstrate the highly selective, active, and long-term durable electrocatalytic production of ethylene from CO 2 by constructing a Cu 2 O nano-homojunction, which is composed of Cu 2 O nanocubes in size of ≈100 nm and the surface-adhered Cu 2 O nanodots in size of ≈12 nm, as electrocatalyst. The maximum Faradaic efficiency of ethylene can reach 73.7% at −1.4 V versus reversible hydrogen electrode in H-type cell, with partial current density to ethylene of 38.2 mA cm −2 . Moreover, it can work stably for more than 200 h at 0.31 A cm −2 in membrane electrode assembly. The mechanism for the high selectivity, activity and stability for CO 2 -to-ethylene conversion was investigated by in situ experiments and theoretical calculations. The results reveal that such a catalyst is efficient in adsorbing CO 2 , stabilizing the key intermediate * CO, and facilitating both the * CO protonation to form * CHO and the subsequent * CO- * CHO coupling for ethylene formation.}, archive = {J_ANGEW}, author = {Renjie Zhang and Jianling Zhang and Yi Song and Yisen Yang and Meiling Li and Yingzhe Zhao and Yunan Teng and Buxing Han and Zhongjun Chen}, doi = {10.1002/anie.202501554}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202501554}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cu2O nano-homojunction for high-efficiency electrocatalytic CO2-to-ethylene conversion}, volume = {64}, year = {2025}, }
• (2025). Conformational change in a four-tetrad DNA G-quadruplex upon intercalation of a small-molecule ligand PyDH2. ANGEW, 64(31), e202501443. (www)

  @article{ , abstract = {G-quadruplexes (G4s) are non-canonical DNA structures implicated in a number of biological processes. Small-molecule ligands can alter stability and folding of G4s, which can potentially be exploited for therapeutic purposes. In this work, we investigate the interaction of telomeric DNA fragment from Tetrahymena thermophila (TET25, 5′-G(TTGGGG) 4- 3′) with a G4 ligand PyDH2 belonging to the bisquinolinium family. When alone, TET25 adopts a mixture of three conformations, with the most abundant being a four-tetrad hybrid G4. In the presence of PyDH2, surprisingly, TET25 folds into an antiparallel chair G4, with PyDH2 intercalated between G-tetrads 2 and 3, according to our crystal structure. The structure represents the second example, and the first crystallographic evidence, of ligand intercalation into a G4. In solution, the interaction of PyDH2 and TET25 leads to a number of complexes differing by G4 topology and binding stoichiometry, strong stabilization of G4 (∆ T m = 12.4 °C in the presence of one equiv. of PyDH2) and large hysteresis of ∼10 °C, suggesting that ligand binding and G4 folding processes are complex.}, archive = {J_ANGEW}, author = {Kailey N. Martin and Gwendolyn Lam and Oksana Reznichenko and Kyle E. Brunner and Michael J. Zdilla and Sawyer E. McCarthy and Anton Granzhan and Liliya A. Yatsunyk}, doi = {10.1002/anie.202501443}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202501443}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformational change in a four-tetrad DNA G-quadruplex upon intercalation of a small-molecule ligand PyDH2}, volume = {64}, year = {2025}, }
• (2025). Surface halide manipulation for stable inorganic perovskite solar cells and modules. ANGEW, 64(31), e202501164. (www)

  @article{ , abstract = {Iodine-rich inorganic perovskites possessing desirable bandgaps as well as high thermal and chemical stability are facing serious issues of low polymorphic stability, whereas chlorine-rich inorganic perovskites hold outstanding thermodynamic stability but suffer from low efficiency. Here, we develop function-gradient inorganic perovskites adopting a surface halide substitution strategy, where a stable chlorine-rich skin protects efficient iodine-rich layers, incorporating high stability of chlorine-rich perovskites with high efficiency of iodine-rich perovskites. This strategy simultaneously passivates surface defects and stabilizes the photoactive polymorphs of perovskite, leading to a power conversion efficiency of 21.2% for unit cells (0.16 cm 2 ) and 19.2% for solar modules (23.9 cm 2 ). Notably, the compositional gradient mitigates light-induced ion migration and enhances resistance to environmental erosion. Thus, our devices exhibit negligible efficiency loss after 1000 h storage in air and 3200 h operation under continuous 1-sun illumination at 40 °C, representing the most stable wide-bandgap perovskite solar cells reported to date.}, archive = {J_ANGEW}, author = {Xiangnan Sun and Peikun Zhang and Tianjun Liu and Bingkun Tian and Peng Xu and Ying Jiang and Jinping Zhang and Yajing Tang and Zhili Hu and Wei Zhang and Zhuhua Zhang and Xiaoming Zhao and Wanlin Guo}, doi = {10.1002/anie.202501164}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202501164}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface halide manipulation for stable inorganic perovskite solar cells and modules}, volume = {64}, year = {2025}, }
• (2025). Rhodium-catalyzed asymmetric access to P-chiral triarylphosphine oxides via insertion of P─H bonds into diazonaphthoquinones. ANGEW, 64(31), e202500436. (www)

  @article{ , abstract = {While significant progress has been made in the enantioselective insertion of carbenes into heteroatom-hydrogen bonds, this chemistry is restricted to the construction of carbon-based chirality. The asymmetric insertion of carbenes into P─H that delivers P-chiral products remains untouched. Rhodium(I)-catalyzed enantioselective synthesis of P-chiral triarylphosphine oxides via asymmetric C─P coupling of a secondary phosphine oxide (SPO) with diazonaphthoquinone is herein reported. Driven by aromatization, this protocol affords a variety of P-chiral triarylphosphine oxides tethered to a 2-naphthol functionality in excellent enantioselectivity by following a kinetic resolution reaction pattern. The diverse synthetic and catalytic applications of the P-chiral products highlight the value of this method, even though the derivatized trivalent chiral phosphine bears a rather low barrier of racemization.}, archive = {J_ANGEW}, author = {Yulong Kang and Yue Shi and Genping Huang and Xingwei Li}, doi = {10.1002/anie.202500436}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202500436}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhodium-catalyzed asymmetric access to P-chiral triarylphosphine oxides via insertion of P─H bonds into diazonaphthoquinones}, volume = {64}, year = {2025}, }
• (2025). HF-free manufacturing of fluorochemicals from fluorspar. ANGEW, 64(31), e202500255. (www)

  @article{ , abstract = {Fluorochemicals are vital in modern chemistry, from batteries to agrochemicals and pharmaceuticals. However, their production still relies on a centuries-old method involving the production of hydrofluoric acid (HF). Recently, Gouverneur and co-workers developed innovative, and more sustainable approaches starting from naturally occurring fluorspar (CaF₂), reducing environmental impact.}, archive = {J_ANGEW}, author = {Ricardo I. Rodríguez and Luca Dell'Amico}, doi = {10.1002/anie.202500255}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202500255}, shortjournal = {Angew. Chem. Int. Edit.}, title = {HF-free manufacturing of fluorochemicals from fluorspar}, volume = {64}, year = {2025}, }
• (2025). Rhodium-catalyzed 1,5-sigma migratory ring expansion of gem-difluorodienyl cyclopropanes and cyclobutanes. ANGEW, 64(31), e202500074. (www)

  @article{ , abstract = {Rhodium-catalyzed 1,5-sigma migratory ring expansion (SMRE) of common dieneylcyclopropanes (DECPs) and dieneylcyclobutanes (DECBs) fails. But replacing the terminal CH 2 group with CF 2 group for both DECPs and DECBs, the resulting substrates of gem -difluorodienyl cyclopropanes (df-DECPs) and gem -difluorodienyl cyclobutanes (df-DECBs) can achieve this reaction, which has broad reaction scope and high efficiency to give seven- and eight-membered carbocycles with a carbonyl group. The keys to the success of this reaction are: oxidative cyclometalation becomes easier with the help of two F atoms; the metallacycle intermediate can detour the sluggish reductive elimination by defluorination to generate Rh carbene intermediate (defluorocarbenation process), which can undergo easier carbene migratory insertion and β-H elimination, giving rise to the final products. Mechanistic studies via experiments and quantum chemical calculations support the proposed mechanism. The gem -difluoro ene in the substrates of df-DECPs and df-DECBs of the present SMRE reaction can be regarded as a ketene surrogate, and this strategy can be exploited in many transition-metal-catalyzed reactions in the future.}, archive = {J_ANGEW}, author = {Zhiqiang Huang and Sixuan Zhao and Zhi-Xiang Yu}, doi = {10.1002/anie.202500074}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202500074}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhodium-catalyzed 1,5-sigma migratory ring expansion of gem-difluorodienyl cyclopropanes and cyclobutanes}, volume = {64}, year = {2025}, }
• (2025). Completing the biosynthesis of the clinically important diterpenoid andrographolide in andrographis paniculata. ANGEW, 64(31), e202425303. (www)

  @article{ , abstract = {Andrographolide is a prominent labdane diterpenoid extracted from Andrographis paniculata with exceptional anti-inflammatory properties. Commercial production of andrographolide relies exclusively on extraction from plant resources. Although the scaffold of andrographolide ent -copalol has previously been biosynthesized, further oxidative modifications remain elusive. In this study, by taking an integrated analysis of transcriptomes and metabolomes, we were able to identify four cytochrome P450 enzymes constituting the minimal set of andrographolide biosynthetic genes. Specifically, ApCYP71D587 catalyzes the conversion of ent -copalol to 19-hydroxy- ent -copalol. Subsequently, ApCYP71BE50 mediates the formation of the lactone ring, ultimately yielding andrograpanin. Then ApCYP706U5 accomplishes the third step by mediating the C-3 hydroxylation reaction, thereby allowing the formation of 14-deoxyandrographolide. Ultimately, ApCYP72F1 completes the biosynthetic generation of andrographolide with C-14 hydroxylation of the lactone and rearrangement of the olefin bond. In addition, co-expression of the minimal gene set in N. benthamiana engineered to produce ent -copalol feasibly produces andrographolide, thus establishing an innovative metabolic engineering strategy to produce this medicine of historical importance, circumventing the need for plant extraction.}, archive = {J_ANGEW}, author = {Sifan Wang and Miaomiao Liang and Weiqiang Chen and Huihua Wan and Xiangxiao Meng and Xuewen Zhu and Yuhong Lu and Qi Shen and Chunhong Jiang and Ning Xie and Shilin Chen and Meirong Jia and Wei Sun}, doi = {10.1002/anie.202425303}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202425303}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Completing the biosynthesis of the clinically important diterpenoid andrographolide in andrographis paniculata}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bond-directed supramolecular organic semiconductor thin films realized via thermal precursor approach. ANGEW, 64(31), e202425188. (www)

  @article{ , abstract = {Flexible organic semiconductors are regarded as an important class of functional materials, enabling their fabrication via a solution-processed method. However, supramolecularly designed organic thin-film transistor (OTFT) devices using hydrogen bonds have not been sufficiently developed. This is because of the reduced solubility caused by introducing hydrogen bond sites and the difficulty in controlling molecular orientations and packing structures. Herein, we report a reasonable strategy for the formation of hydrogen-bonded semiconductor thin films of a tetrabenzoporphyrin derivative with amide groups using the thermal precursor approach. The thin films are successfully fabricated by thermal conversion of the corresponding precursor in the film state. Assembly structure with a hydrogen-bond network is revealed by the combination of X-ray diffraction and infrared p-polarized multiple-angle incidence resolution spectrometry. The OTFT devices exhibit high hole mobility of 0.25 cm 2 V −1 s −1 among hydrogen-bonded OTFTs reported previously. Notably, we unveiled the high thermal stability of semiconductor films without decreasing device performance in air up to 250 °C. This strategy can become a key methodology to form hydrogen-bond-directed organic electronic devices, namely supramolecular devices.}, archive = {J_ANGEW}, author = {So Ueno and Mitsuaki Yamauchi and Nobutaka Shioya and Hiroshi Matsuda and Takeshi Hasegawa and Keitaro Yamamoto and Yoshiyuki Mizuhata and Hiroko Yamada}, doi = {10.1002/anie.202425188}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202425188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bond-directed supramolecular organic semiconductor thin films realized via thermal precursor approach}, volume = {64}, year = {2025}, }
• (2025). Suppressing the interface photodegradation towards efficient and stable all perovskite tandem solar cells. ANGEW, 64(31), e202424825. (www)

  @article{ , abstract = {All perovskite tandem solar cells (PTSCs) were expected to overcome the Shockley-Queisser limit of single-junction perovskite solar cells (PSCs). Nevertheless, wide bandgap (WBG) subcells suffer from large photovoltage loss and device instability due to extensive film defect, interfacial degradation and phase segregation. Herein, a polymeric multi-dentate anchoring (PMDA) strategy by introducing poly(carbazole phosphonic acid) was employed to engineer the bottom interface and suppress phase segregation. The reinforced and homogeneous anchorage by multiple repeat phosphonic acid groups onto NiO x significantly optimised the bottom interface, suppressing unfavourable interfacial reactions and thus alleviating phase segregation of WBG perovskite. As a result, the PMDA-modified WBG PSCs showed higher power conversion efficiency (PCE) than the control device (19.84% vs. 18.18%), along with better device photostability ( T 80 = 1200 vs. 500 h). Coupled with narrow bandgap (NBG) PSCs, the PMDA-modified PTSCs reached a PCE of up to 28.51% with device operation photostability over 700 h ( T 80 ).}, archive = {J_ANGEW}, author = {Zhuojia Lin and Jianwei Chen and Kezhou Fan and Jicheng Yi and Honggang Chen and Shibing Zou and Hongyu Min and Yitong Xu and Man Yu Lam and Sergeev A. Aleksandr and Kam Sing Wong and He Yan and Keyou Yan}, doi = {10.1002/anie.202424825}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202424825}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Suppressing the interface photodegradation towards efficient and stable all perovskite tandem solar cells}, volume = {64}, year = {2025}, }
• (2025). High voltage design for quasi-solid zinc-air batteries. ANGEW, 64(31), e202424318. (www)

  @article{ , abstract = {Alkaline zinc-air batteries (ZABs) are recognized as a promising candidate for next generation of safe battery systems, owing to their inherent advantages. However, the performance of traditional ZABs is constrained by a lower theoretical voltage of 1.65 V, presenting a significant challenge in enhancing their practical application. This paper demonstrates a prototype of acid-alkaline hybrid quasi-solid-state zinc-air battery (HSZAB), featuring a unique design in both a new acidic gel electrolyte and battery structure. Our approach involves regulating the electrolyte pH and ionic conductivity to achieve an enhanced theoretical voltage, resulting in an open circuit voltage of up to 2.0 V. Additionally, the HSZAB demonstrates substantially improved peak power density (417 mW cm −2 , five times higher than the conventional alkaline ZABs) and increased energy efficiency (from 60% to 82%). This finding underscores the promising prospects of high voltage zinc-air batteries, offering a substantial step forward in the field of energy storage systems.}, archive = {J_ANGEW}, author = {Qiang Li and Yan Wang and Zhenhua Song and Xintao Zhu and Xianwen Song and Yang Chen and Yi Zhang}, doi = {10.1002/anie.202424318}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202424318}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High voltage design for quasi-solid zinc-air batteries}, volume = {64}, year = {2025}, }
• (2025). Solid-phase parallel synthesis of photocleavable bifunctional molecules enables efficient phenotypic protein degrader discovery. ANGEW, 64(31), e202424118. (www)

  @article{ , abstract = {Phenotypic screening offers an effective path for discovering protein degraders, particularly targeting proteins that are poorly characterized or lack sufficient ligand-binding information. Nonetheless, phenotypic protein degrader discovery (PPDD) faces practical hurdles, such as synthetic complexity in generating chemically diverse libraries and difficulties in reliably identifying degradation-driven phenotypes in direct-to-biology (D2B) assays. In response to these challenges, we developed an integrated PPDD platform that combines optimized solid-phase parallel synthesis with a robust D2B screening workflow. Leveraging photocleavable linkers and versatile synthetic strategies, this platform facilitates rapid generation of chemically diverse, ready-to-screen bifunctional molecule libraries requiring minimal purification. As a proof of concept, we synthesized and phenotypically screened 130 cereblon-recruiting molecules, leading to several promising protein degradation-dependent hits. Subsequent hit optimization and target identification validated compound 12–60 as a structurally novel GSPT1 degrader with compelling cellular activity. Overall, our integrated platform represents an efficient and practical toolkit for PPDD, establishing a versatile foundation to accelerate future campaigns and expand the degradable proteome.}, archive = {J_ANGEW}, author = {Baoli Ding and Jiawen Hu and Rongtian Zhang and Binyan Shou and Mengdie Chen and Li Jiang and Meng Yuan and Bo Yang and Qiaojun He and Ji Cao and Cheng-Liang Zhu}, doi = {10.1002/anie.202424118}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202424118}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solid-phase parallel synthesis of photocleavable bifunctional molecules enables efficient phenotypic protein degrader discovery}, volume = {64}, year = {2025}, }
• (2025). Phototransposition of indazoles to benzimidazoles: Tautomer-dependent reactivity, wavelength dependence, and continuous flow studies. ANGEW, 64(31), e202423803. (www)

  @article{ , abstract = {Herein, we report a detailed investigation of the photomediated transformation of indazoles to benzimidazoles through a nitrogen–carbon transposition. This phototransposition is known to occur in low yield when 1 H -indazoles are subjected to high-energy UVC irradiation. The 2 H -tautomer of indazole absorbs light more strongly than the 1 H -tautomer at longer wavelengths. We leveraged this improved absorbance profile to develop a general system for the high-yielding conversion of N2-derivatized indazoles (prepared from the corresponding 1 H -indazoles) to the corresponding benzimidazoles under UVB or UVA irradiation in up to 98% yield. Investigation of the substrate scope revealed a strong correlation between reaction yield and electron density at N2 of the indazole substrate, suggesting the importance of the availability of the lone pair at this position for reaction efficiency. In addition, evaluation of wavelength-dependent reactivity through the generation of a photochemical action plot revealed that the highest conversion does not only occur at the substrate's maximum absorbance wavelength but also on its red-side, enabling the use of longer wavelength irradiation to achieve high yields. Building on these insights, a continuous flow protocol was established that enables the phototransposition on preparative scale.}, archive = {J_ANGEW}, author = {G. Logan Bartholomew and Sojung F. Kim and Yusuke Oyamada and Federica Sbordone and Joshua A. Carroll and Justin E. Jurczyk and Charles S. Yeung and Christopher Barner-Kowollik and Richmond Sarpong}, doi = {10.1002/anie.202423803}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202423803}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phototransposition of indazoles to benzimidazoles: Tautomer-dependent reactivity, wavelength dependence, and continuous flow studies}, volume = {64}, year = {2025}, }
• (2025). Surfactants screen slide electrification. ANGEW, 64(31), e202423474. (www)

  @article{ , abstract = {Water drops spontaneously accumulate charges when they move on hydrophobic dielectric surfaces by slide electrification. Slide electrification generates electricity with possible applications on tiny devices. The potential of up to 1 KV generated by slide electrification alters wetting and drop motion. Therefore, it is important to know the factors that affect slide electrification. To find out how surfactants affect slide electrification, we measured drop charges of aqueous drops containing cationic CTAB, anionic SDS, and neutral C 8 E 3 sliding on different hydrophobic surfaces. The result is: addition of surfactant significantly reduces the spontaneous charging of moving water drops. Based on zeta potential measurements, confocal microscopy of deposited surface-active dyes and drop impact studies, we propose that several factors contribute to this suppression of charge separation: (1) Surfactants tend to lower the contact angles, which reduces charge separation. (2) Surfactant adsorption at the solid-liquid interface can reduce the density of primary ions, particularly for anionic surfactants. (3) Anionic and neutral surfactants are mostly transferred to the liquid-air interface at the rear of the sliding drop, retaining primary ions within the drop. (4) Deposited cationic surfactant directly reduces the charge of the drop.}, archive = {J_ANGEW}, author = {Xiaomei Li and Zhongyuan Ni and Xiaoteng Zhou and Lisa S. Bauer and Diego Diaz and Gabriele Schäfer and Hans-Jürgen Butt}, doi = {10.1002/anie.202423474}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202423474}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surfactants screen slide electrification}, volume = {64}, year = {2025}, }
• (2025). A resonance hybrid design for stable aqueous organic redox flow batteries. ANGEW, 64(31), e202423219. (www)

  @article{ , abstract = {Organic molecules are promising candidates for aqueous organic redox flow batteries (AORFBs) due to their structural versatility, tunability, and reliance on earth-abundant elements for sustainable energy storage solutions. However, achieving stability for organic molecules in aqueous batteries remains challenging due to water-induced degradation. The conjugated systems with enhanced rigidity, such as anthraquinone or phenazine derivatives, have shown improved stability, yet often exhibit unwanted restructuring reactions in the reduced state due to overly high electron densities, leading to the loss of redox activity. In the present work, we introduce a resonance hybrid, 2,3-dihydroxyl substituted phenazine dication (HSPC), whose redox center is distributed among different resonance forms between phenazine and quinone to enable efficient reversible electron transfer in aqueous environments. The electrochemical synthesis, resonance structure, and key properties of HSPC were investigated through a framework of combined electrochemical measurements, spectroscopic analysis, and theoretical studies. A 1.4 M electron concentration cell based on HSPC exhibits a low capacity decay rate of 0.0009% per cycle, 0.006% per day. These results indicate the significant potential of the resonance hybrid design to build stable redox materials for AORFBs and other energy storage applications.}, archive = {J_ANGEW}, author = {Lu Li and Enze Yao and Yunlong Ji and Pan Wang}, doi = {10.1002/anie.202423219}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202423219}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A resonance hybrid design for stable aqueous organic redox flow batteries}, volume = {64}, year = {2025}, }
• (2025). ABC-seq expands small RNAs profiling with successive nucleic acid structure-differentiated enzymatic recognition. ANGEW, 64(31), e202423208. (www)

  @article{ , abstract = {Small RNAs (smRNAs) play crucial roles in gene regulation, but current sequencing methods face a set of tangled challenges, including adapter ligation bias, high adapter dimer byproducts, and amplification variability, which limit their capacity to fully capture smRNA diversity. Here, we develop ABC-seq, a general strategy to enhance smRNA recognition through successive structure-differentiated recognition. We designed two randomized adapters, each containing a restriction enzyme recognition motif or a cleavage site. Then, we operate two product structure-differentiated enzymatic reactions to maximally suppress randomized adapter dimer. Furthermore, the randomized sequence in adapters serves as unique molecular identifiers (UMIs) in smRNA-seq data analysis to correct amplification bias and improves quantification accuracy. Using ABC-seq, we identified a wider range of smRNAs, including miRNAs, scRNAs, and snoRNAs, in hypertrophic cardiomyocytes, detecting 9.4% more miRNAs compared to traditional methods. Additionally, ABC-seq revealed smRNAs associated with cancer drug responses and their roles in immune modulation in non-small cell lung cancer. ABC-seq expands the smRNA landscape and offers new insights into complex gene regulatory networks.}, archive = {J_ANGEW}, author = {Huahang Yu and Mengying Ye and Yingying Guo and Yating Sun and Ke Cao and Dexin Zhang and Feng Chen and Yongxi Zhao}, doi = {10.1002/anie.202423208}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202423208}, shortjournal = {Angew. Chem. Int. Edit.}, title = {ABC-seq expands small RNAs profiling with successive nucleic acid structure-differentiated enzymatic recognition}, volume = {64}, year = {2025}, }
• (2025). Access to diverse activatable heptamethine cyanine probes with low intrinsic fluorescence via 5-exo-trig cyclization strategy for high-contrast bioimaging in vivo. ANGEW, 64(31), e202423059. (www)

  @article{ , abstract = {The conversion of conventional “always-on” cyanine dyes into activatable NIR probes with low inherent fluorescence remains challenging, resulting in poor imaging contrast and nonspecific response in vivo. We herein report a 5- exo-trig cyclization strategy to create diverse activatable heptamethine cyanine probes with “zero” intrinsic background fluorescence for high-contrast bioimaging. This intramolecular ring-closure approach imparts a built-in switch to regulate the fluorescence of cyanine dyes, which predominantly exist in the nonfluorescent closed-loop form at pH over 5.0 and are not affected by environmental polarity and protein interaction, thereby reducing false-positive fluorescent signals. Upon reaction with various biomarkers, including methylglyoxal (MGO), hydroxyl radical (·OH), and adenosine triphosphate (ATP), they could rapidly transform into fluorescent open-loop structures, showing significant NIR fluorescence enhancement (up to 184-fold). Furthermore, we extended this strategy to develop a variety of NIR-II ATP-activatable cyanine probes for the first time, as well as a theranostic probe 57 using host–guest chemistry. Probe 57 not only sensitively monitored ATP levels in inflammatory bowel disease (IBD) with a high signal-to-background ratio of 48/1, but it also precisely detected extracellular ATP in stools. This work opens a new avenue to develop stimuli-responsive NIR cyanine probes for improving disease diagnosis.}, archive = {J_ANGEW}, author = {Fapu Wu and Bingbing Zheng and Xinyu Qiu and Tao Hu and Yuexia Yang and Kairong Yang and Bijia Zhou and Qian Ma and Dai-Wen Pang and Hu Xiong}, doi = {10.1002/anie.202423059}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202423059}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Access to diverse activatable heptamethine cyanine probes with low intrinsic fluorescence via 5-exo-trig cyclization strategy for high-contrast bioimaging in vivo}, volume = {64}, year = {2025}, }
• (2025). Technoeconomic perspective on the electroreduction of CO2 to formic acid: Scale-up strategies toward industrial viability. ANGEW, 64(31), e202418114. (www)

  @article{ , abstract = {The conventional industrial synthesis of formic acid is an energy-intensive process that contributes to the CO 2 footprint. As an alternative method, the electrochemical reduction of carbon dioxide (eCO 2 RR) to formic acid has emerged as a viable means to reduce atmospheric CO 2 concentrations and advance the energy transition to a circular, carbon-neutral economy. Despite considerable progress in this field, the scale-up of electrolyzers from laboratory prototypes to commercial-scale production remains an important challenge. Thus, this technoeconomic analysis provides a detailed evaluation of the economic viability of upscaling the electrolyzer size to an industrial level, determining whether the eCO 2 RR process can economically compete with the conventional industrial production of formic acid. The proposed technoeconomic assessment employs a bottom-up approach based on realistic cost models using the three most successful designs: dual flow (DF), direct formic acid production (DFAP), and zero-gap (ZG) electrolyzers. The results from this study underscore the necessity of implementing multiple-cell stacking to economically compete with established industrial processes. Among the three studied designs, DFAP and, to a certain extent, DF are promising. Although the scalability of the DFAP electrolyzer may initially appear inadequate, it holds potential for commercial application, particularly if technical improvements in the center compartment and solid-state electrolyte are materialized.}, archive = {J_ANGEW}, author = {Urbain Nzotcha and Sergio Sanz and Hermann Tempel and Rüdiger-A. Eichel}, doi = {10.1002/anie.202418114}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {31}, pages = {e202418114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Technoeconomic perspective on the electroreduction of CO2 to formic acid: Scale-up strategies toward industrial viability}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Highly enantioselective organocatalysis with bidentate halogen bond donors. ANGEW, 64(30), e202583002. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583002}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202583002}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Highly enantioselective organocatalysis with bidentate halogen bond donors}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Utilizing the Mn(II) dissolution-induced vacancy for optimum mg2+ storage of spinel Mn3O4. ANGEW, 64(30), e202583001. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202583001}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202583001}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Utilizing the Mn(II) dissolution-induced vacancy for optimum mg2+ storage of spinel Mn3O4}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: In-situ observation of post-CO intermediates to decode C─C coupling pathways in CO2 electroreduction (Angew. chem. int. ed. 30/2025). ANGEW, 64(30), e202513961. (www)

  @article{ , archive = {J_ANGEW}, author = {Mingxu Sun and David S. Rivera Rocabado and Jiamin Cheng and Tomohiro G. Noguchi and Masaki Donoshita and Takahiro Matsuu and Manabu Higashi and Tsuyohiko Fujigaya and Takayoshi Ishimoto and Miho Yamauchi}, doi = {10.1002/anie.202513961}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202513961}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: In-situ observation of post-CO intermediates to decode C─C coupling pathways in CO2 electroreduction (Angew. chem. int. ed. 30/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Boosting current density of electrocatalytic CO2 reduction using metal-enzyme hybrid cathodes (Angew. chem. int. ed. 30/2025). ANGEW, 64(30), e202513516. (www)

  @article{ , archive = {J_ANGEW}, author = {Yeomin Kang and Yunjae Kim and Youngjin Doh and Jinwoo Lee and Jungbae Kim and Ki Tae Park}, doi = {10.1002/anie.202513516}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202513516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Boosting current density of electrocatalytic CO2 reduction using metal-enzyme hybrid cathodes (Angew. chem. int. ed. 30/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Dual-responsive ultrathin polymersomes with reversible transitions on acidochromism and fluorochromism performances for multiple information encryption (Angew. chem. int. ed. 30/2025). ANGEW, 64(30), e202513507. (www)

  @article{ , archive = {J_ANGEW}, author = {Zichao Sun and Zejiang Xu and Pengchao Wu and Liquan Wang and Mingyu Ding and Lin Zhao and Yongli Zheng and Yongfeng Zhou and Shaoliang Lin and Haibao Jin}, doi = {10.1002/anie.202513507}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202513507}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Dual-responsive ultrathin polymersomes with reversible transitions on acidochromism and fluorochromism performances for multiple information encryption (Angew. chem. int. ed. 30/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Supramolecularly engineered reporters with superoxide anion triggered chemiluminescence for early diagnosis and efficient amelioration of acute kidney injury”. ANGEW, 64(30), e202513504. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202513504}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202513504}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Supramolecularly engineered reporters with superoxide anion triggered chemiluminescence for early diagnosis and efficient amelioration of acute kidney injury”}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Molecular-level interface engineering and additive-induced crystallinity tuning for high-performance thermally conductive polymer composites (Angew. chem. int. ed. 30/2025). ANGEW, 64(30), e202513328. (www)

  @article{ , archive = {J_ANGEW}, author = {Minwoo Rim and Huan Huu Pham and Hyerim Lee and Jaeseok Hyeong and Youngjae Wi and Jahyeon Koo and Duy Thanh Tran and Seok-In Na and Dong-Gue Kang and Kwang-Un Jeong}, doi = {10.1002/anie.202513328}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202513328}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Molecular-level interface engineering and additive-induced crystallinity tuning for high-performance thermally conductive polymer composites (Angew. chem. int. ed. 30/2025)}, volume = {64}, year = {2025}, }
• (2025). Durga prasad hari. ANGEW, 64(30), e202512389. (www)

  @article{ , archive = {J_ANGEW}, author = {Durga Prasad Hari}, doi = {10.1002/anie.202512389}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202512389}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Durga prasad hari}, volume = {64}, year = {2025}, }
• (2025). Ryo inoue. ANGEW, 64(30), e202512191. (www)

  @article{ , archive = {J_ANGEW}, author = {Ryo Inoue}, doi = {10.1002/anie.202512191}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202512191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ryo inoue}, volume = {64}, year = {2025}, }
• (2025). Hydroxyl-promoted C─C coupling for selective methane conversion into ethane on cerium oxide photocatalyst. ANGEW, 64(30), e202510032. (www)

  @article{ , abstract = {Converting methane into high-value chemicals under mild conditions offers substantial environmental and energy benefits but is challenged by the difficulty of activating C─H bonds and preventing over-oxidation. In this study, the pivotal role of hydroxyl-rich surfaces on noble-metal-free photocatalysts is demonstrated in directing selective C─C coupling of methane. These surface hydroxyls not only enhance methane chemisorption and improve charge separation, but also promote favorable interactions with molecular oxygen, collectively boosting catalytic performance. Furthermore, the hydroxyl groups lower the energy barrier for ethane formation while suppressing its over-oxidation to CO 2 , resulting in significantly improved selectivity. Under ambient conditions in a flow-reactor system, the catalyst achieves a continuous ethane production rate of 187 µmol·g −1 ·h −1 with approximately 97% selectivity over an extended operation period (>200 h), surpassing previous noble-metal-free photocatalytic systems. This work provides critical insights into the role of hydroxyl-modified local environment in methane valorization, paving the way for the development of sustainable and efficient catalytic systems.}, archive = {J_ANGEW}, author = {Lei Luo and Rong Wang and Zongxu Wu and Yejun Xiao and Jiangnan Li and Zhaochi Feng and Fuxiang Zhang}, doi = {10.1002/anie.202510032}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202510032}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydroxyl-promoted C─C coupling for selective methane conversion into ethane on cerium oxide photocatalyst}, volume = {64}, year = {2025}, }
• (2025). Modulating the polarity of imine bonds in Donor–Acceptor covalent organic frameworks for enhanced photocatalytic h2 production. ANGEW, 64(30), e202509444. (www)

  @article{ , abstract = {The development of imine-linked covalent organic frameworks (COFs) has also drawn attention to the influence of the nature of imine binding, including its orientation and possible protonation, on the chemical and physical properties of imine COFs. However, the influence of the polarity of imine bond (C═N) on the photocatalytic performance of COFs has not yet been described. In this work, we synthesized a series of imine COFs with differently polarized C═N bonds by altering the C═N bond orientation and regulating the donor–acceptor (D–A) strength, respectively. The less polarized C═N bond for one of the COFs possesses a faster charge separation with a decrease of exciton binding energy ( E b ). In contrast, the imine COF with more polarized C═N bond exhibits a stronger internal electric field contributing to a more efficient charge transfer. Taking into account this trade-off between binding energy and charge transfer concerning the effect of C═N polarity on the photocatalytic performances, the imine COF with moderately polarized C═N bond shows the highest hydrogen evolution performance of 14.0 mmol h −1 g −1 . This work provides evidence that the polarity of C═N should be taken into account when designing and tuning the properties of imine COFs.}, archive = {J_ANGEW}, author = {Zixuan Li and Bingzi Cai and Qun Li and Di Zhang and Yizhao Liang and Yuanyuan Liu and Yalong Jiao and Arne Thomas and Xiaojia Zhao}, doi = {10.1002/anie.202509444}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202509444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating the polarity of imine bonds in Donor–Acceptor covalent organic frameworks for enhanced photocatalytic h2 production}, volume = {64}, year = {2025}, }
• (2025). Rational design of type-I photodynamic agents. ANGEW, 64(30), e202509416. (www)

  @article{ , abstract = {Type-I photodynamic agents can not only produce cytotoxic reactive oxygen species, but also directly damage biomolecules through electron/hydrogen transfer process, exhibiting reduced dependence on oxygen concentration in photodynamic therapy (PDT). The rational design of Type-I photodynamic agents has attracted increasing attention. This minireview provides a comprehensive overview of Type-I PDT and its advantages in treating hypoxic tumors. It systematically outlines two complementary design strategies: i) thermodynamic modulation through molecular engineering to block the Type-II energy transfer pathway, and ii) kinetic enhancement of electron/hydrogen transfer to favor the Type-I mechanism. Finally, key challenges in Type-I PDT are discussed, and future perspectives are highlighted to facilitate the clinical translation of Type-I photodynamic agents. We hope this review will stimulate further progress in the development of innovative PDT.}, archive = {J_ANGEW}, author = {Kun-Xu Teng and Li-Ya Niu and Jiahui Li and Dongsheng Zhang and Qing-Zheng Yang}, doi = {10.1002/anie.202509416}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202509416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design of type-I photodynamic agents}, volume = {64}, year = {2025}, }
• (2025). Introducing functional groups into B←N organic frameworks with permanent porosity. ANGEW, 64(30), e202509174. (www)

  @article{ , abstract = {Crystalline organic frameworks incorporating dative B←N and reversible B─O bonds (BNOFs) have garnered increasing interest on account of their crystallinity, porosity, and processability. However, strategies for introducing functions into BNOFs remain largely unexplored. In this work, a series of functionalized BNOFs, named BNOF- n ( n = 2–9), have been designed and synthesized using a mixed-monomer assembly strategy. The obtained materials share structural similarities but reveal distinct functional groups, demonstrating excellent chemical stability, high surface areas, and remarkable regenerability. Notably, BNOF-5, functionalized with abundant carboxyl groups, achieves exceptional reversible NH 3 adsorption capacity (up to 10.0 mmol g −1 at 1 bar and 298 K), significantly surpassing that of the nonfunctionalized BNOF-1 (5.6 mmol g −1 ) and the less-functionalized BNOF-7 (7.9 mmol g −1 ), thereby clearly demonstrating the effectiveness of the functionalization strategy. Remarkably, the damaged BNOF-5 can be efficiently repaired through facile regeneration, highlighting its outstanding recyclability. This work demonstrates the first attempt at functionalization methodology in BNOFs, extending their potential toward diverse applications.}, archive = {J_ANGEW}, author = {Huifang Zhou and Tiantian Jiang and Kangjian Fu and Xinyu Guan and Shilin Guan and Bo Liu and Hai-Long Jiang}, doi = {10.1002/anie.202509174}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202509174}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Introducing functional groups into B←N organic frameworks with permanent porosity}, volume = {64}, year = {2025}, }
• (2025). Enantioselective immobilization of nonprecious metal complexes on chiral covalent organic frameworks for improved single-site photocatalytic hydrogen evolution. ANGEW, 64(30), e202509095. (www)

  @article{ , abstract = {The noncovalent assembly of molecular catalysts into photocatalytic systems represents a pivotal strategy for exploring single-site heterogenous catalysts, excluding the need for elaborate functionalization design. However, the reliance on weak noncovalent interactions (e.g., van der Waals forces) often leads to inefficient outer-sphere electron transfer and inferior structural stability. Herein, we report the enantioselective immobilization of cobalt-based molecular catalysts with chiral tetradentate ligands onto the surface of a β -ketoenamine-linked chiral covalent organic framework (COF) synthesized through chirality induction. The enantiomeric assembly enables axial coordination between the molecular catalysts and the chiral COF, accompanied by enamine-to-imine tautomerization. Leveraging efficient inner-sphere electron transfer, the resulting composite exhibits a significantly enhanced H 2 evolution rate (5.70 mmol g −1 h −1 ) and sustained performance without the use of precious metals. The enantiomeric assembly strategy on a COF platform demonstrates a viable approach to improve both the stability and activity of molecular catalysts, thereby expanding the design paradigm of single-site photocatalysts.}, archive = {J_ANGEW}, author = {Xingye Huang and Wanting Xie and Tiantian Xu and Weijun Weng and Ting Zhou and Jia Guo}, doi = {10.1002/anie.202509095}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202509095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective immobilization of nonprecious metal complexes on chiral covalent organic frameworks for improved single-site photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). A neutral single-molecule carrier for delivery of phosphonate drugs. ANGEW, 64(30), e202509002. (www)

  @article{ , abstract = {Phosphate/phosphonate-based drugs (PDs), as multinegative, hydrophilic molecules, face the greatest difficulty in diffusion across biological membranes, leading to poor bioavailability. Conventional drug delivery strategies to overcome this issue, including utilizing small-molecule prodrugs or nanoparticle carriers, often suffer from case-specific modifications or uncertainties in drug loading. Inspired by the anion coordination chemistry of natural phosphate transporters and artificial anion receptors, here, we present the first use of a neutral anion receptor, i.e., bis(tripodal hexaurea) cage 1 , as a “single-molecule carrier” for the delivery of PDs into living cells. Cage 1 features advantages of molecular-level encapsulation, enhanced intracellular accumulation, subcellular targeting, responsive drug release, and broad adaptability. It enhances PD accumulation in tumor cells both in vitro and in vivo, enhancing the cellular uptake of mono-, di-, and tri-phosphate/phosphonate substrates by up to 45-fold via a macropinocytosis-mediated endocytosis pathway. This work demonstrates the potential of neutral anion receptors to serve as single-molecule carriers and offers a promising solution for improving PDs bioavailability, advancing the development of antitumor phosphate/phosphonate-based drugs.}, archive = {J_ANGEW}, author = {Qingling Nie and Juan Tang and Yongsheng Li and Ji Wang and Boyang Li and Hongwei Ma and Xiao-Juan Yang and Wei Zhao and Biao Wu}, doi = {10.1002/anie.202509002}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202509002}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A neutral single-molecule carrier for delivery of phosphonate drugs}, volume = {64}, year = {2025}, }
• (2025). HFIP-promoted E-selective asymmetric crotylboration of quaternary α-silyl crotylboronate with aldehydes. ANGEW, 64(30), e202508944. (www)

  @article{ , abstract = {Polyketide synthesis consistently requires the development of linchpin-type allylboron reagents, such as α-silyl crotylboronates. Traditionally, these reagents feature α-tertiary substitution and are used in aprotic solvents, typically yielding homoallylic alcohols with disubstituted ( Z )-vinylsilanes. Here, we report the asymmetric synthesis of enantioenriched quaternary α-silyl crotylboronates via stereospecific allylic Matteson homologation. We further demonstrate that hexafluoroisopropanol (HFIP)—a polar alcoholic solvent that has been underutilized in allylboration—not only enhances reaction reactivity but also overrides the typical ( Z )-selectivity, enabling access to the otherwise challenging ( E )-selective products. The method enables the rapid construction of ( E )-anti-2,4-dimethylpent-3-en-1-oxy motif, a structural unit frequently found in polyketides, and allows the protecting-group-free synthesis of PM050463. DFT calculations suggest that HFIP's strong hydrogen bonding effect increases the Lewis acidity of the boron center and the steric effect of Bpin, resulting in high yields and ( E )-selectivity.}, archive = {J_ANGEW}, author = {Ruiqi Tong and Yan Zhang and Shiyang Liu and Jiahui Gao and Liying Huang and Yi Li and Li Fu and Wanshu Wang and Lu Gao and Zhishan Su and Zhenlei Song}, doi = {10.1002/anie.202508944}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508944}, shortjournal = {Angew. Chem. Int. Edit.}, title = {HFIP-promoted E-selective asymmetric crotylboration of quaternary α-silyl crotylboronate with aldehydes}, volume = {64}, year = {2025}, }
• (2025). A synergistic Photocatalysis–Electrocatalysis system for efficient hydrogen generation and energy-saving benzylamine oxidative upgrading. ANGEW, 64(30), e202508893. (www)

  @article{ , abstract = {Photocatalytic hydrogen iodide (HI) splitting represents a promising tactic for H 2 generation, but the light-shielding effect induced by the generated I 3 − greatly impedes subsequent reactions. A critical challenge in this field lies in achieving the timely reduction of I 3 − while avoiding the use of additional sacrificial agents, such as H 3 PO 2 . Herein, we develop a synergistic photocatalysis–electrocatalysis system to address this challenge and achieve efficient H 2 generation and benzylamine oxidative upgrading. The photocatalytic component features a Re 0.5 Mo 0.5 S 2 cocatalyst-modified MAPbI 3 with efficient charge separation and ample active sites, achieving a remarkable H 2 generation of 875.4 µmol within 4 h through HI splitting. The subsequent electrocatalytic module can operate at a low potential (only 0.44 V to reach 10 mA cm −2 ) to reduce the generated I 3 − and oxidize benzylamine to value-added chemicals. After the electrolysis, the regenerated HI solution can be recycled for subsequent photocatalytic H 2 generation. The synergistic system establishes a sustainable catalytic cycle mediated by I − /I 3 − redox couples, enabling continuous photocatalytic H 2 generation from HI splitting and energy-saving electrocatalytic benzylamine oxidative upgrading.}, archive = {J_ANGEW}, author = {Shengchang Hong and Qianqian Zhang and Xiaolei Liu and Zeyan Wang and Yuanyuan Liu and Zhaoke Zheng and Hefeng Cheng and Baibiao Huang and Peng Wang}, doi = {10.1002/anie.202508893}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A synergistic Photocatalysis–Electrocatalysis system for efficient hydrogen generation and energy-saving benzylamine oxidative upgrading}, volume = {64}, year = {2025}, }
• (2025). Self-activated heterogeneous fenton process for accelerated degradation of aromatic pollutants over copper oxide catalysts. ANGEW, 64(30), e202508754. (www)

  @article{ , abstract = {Metal-based heterogeneous catalysts have been commonly adopted for Fenton-like oxidation of organic pollutants, but generally suffer from inadequate activity in practical water treatment applications due to surface passivation by accumulated pollutants and sluggish redox cycling of active metal. Here, we observed an unusual phenomenon of pollutant-induced activity enhancement for copper oxide (CuO) in H 2 O 2 activation and phenol degradation, which is in sharp contrast to considerable activity decay of Fe 2 O 3 catalyst. The CuO was found to stabilize and activate phenol via ligand-to-metal charge transfer route, generating surface-bound phenoxyl radicals for further mediating the H 2 O 2 activation and enabling a rapid regeneration of low-valent Cu. Based on this principle, a Fe-Cu bimetal oxides catalyst was elaborated to further augment the catalyst-phenol interaction towards self-activated Fenton oxidation. The optimal catalyst achieved 14-time faster pollutant degradation rate and 2 order-of-magnitude higher H 2 O 2 utilization efficiency than the Fe 2 O 3 control. It also demonstrated good adaptability to degradation of diverse substituted benzenes and maintained stable performance for treatment of real lake water during 100-day continuous operation. Our work implies that the catalyst-pollutant interaction may be rationally leveraged and modulated to create highly efficient and stable heterogeneous catalytic systems, thus further unlocking their potential for sustainable water purification application.}, archive = {J_ANGEW}, author = {Mingjie Huang and Hong-Zhi Liu and Qing-Qing Huang and Tao Zhou and Xiaohui Wu and Wen-Wei Li and Han-Qing Yu}, doi = {10.1002/anie.202508754}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508754}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-activated heterogeneous fenton process for accelerated degradation of aromatic pollutants over copper oxide catalysts}, volume = {64}, year = {2025}, }
• (2025). Harnessing solvation chemistry of pentavalent vanadium for wide-temperature range vanadium flow batteries. ANGEW, 64(30), e202508456. (www)

  @article{ , abstract = {Vanadium flow batteries (VFBs) are safe, cost-effective, and scalable solutions for storing renewable energies. However, the poor thermal stability of pentavalent vanadium [V(V)] electrolyte, manifested as V 2 O 5 precipitation at high temperatures, leads to more critical heat management, low energy density, and even low reliability. The unclear dynamic solvation chemistry of V(V) ions brings difficulties in solving the above issues intrinsically. Herein, we investigated solvation structures and dynamic evolution of V(V) electrolyte using ab initio molecular dynamics (AIMD) and in situ liquid time-of-flight secondary ion mass spectrometry (ToF-SIMS). For the first time, we clarified the transformation from [VO 2 (H 2 O) 3 ] + to VO(OH) 3 , identifying the second deprotonation as the rate-determining step. Based on this, we developed stabilization strategies through anion coordination and proton concentration control. The incorporation of HCl and trifluoromethanesulfonic acid improved the thermal stability of V(V) electrolytes remarkably. The optimized electrolyte showed no precipitation during 30-day static tests at 50 °C, enabling stable cycling performance of 3000 cycles in VFB single cells. Further demonstration in a kW-scale stack achieved over 1000 cycles, validating the scalability and viability. Our work provides insights into the solvation chemistry of V(V) species, paving the way to improve the reliability and energy density of a VFB system.}, archive = {J_ANGEW}, author = {Chenkai Mu and Tianyu Li and Chengbo Zhan and Qiang Fu and Yuxuan Zhang and Linjuan Zhang and Fuyi Wang and Yanyan Zhang and Xianfeng Li}, doi = {10.1002/anie.202508456}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing solvation chemistry of pentavalent vanadium for wide-temperature range vanadium flow batteries}, volume = {64}, year = {2025}, }
• (2025). A visible-light-driven O-glycosylation with selenoglycosides mediated by chalcogen bonding to umemoto's reagent. ANGEW, 64(30), e202508424. (www)

  @article{ , abstract = {The activation of chalcogenoglycosides for O -glycosylation typically involves strong electrophiles requiring low temperature. Herein, we demonstrate that visible-light irradiation of selenoglycosides in the presence of Umemoto's reagent results in often high-yielding O -glycosylation. We provide evidence that this process is mediated by a novel mode of reactivity, specifically photoinduced electron transfer within a chalcogen-bonded complex.}, archive = {J_ANGEW}, author = {Erik Alvarez Valenzuela and Tiffany Duong and Vinayak Pradeep and Xuxian He and Jacob M. Dobson and Semin Lee and Kenneth Lopata and Justin R. Ragains}, doi = {10.1002/anie.202508424}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A visible-light-driven O-glycosylation with selenoglycosides mediated by chalcogen bonding to umemoto's reagent}, volume = {64}, year = {2025}, }
• (2025). Covalent elaboration of confined surfaces steers C─C coupling pathway for selective electrochemical CO2 reduction at ampere-level. ANGEW, 64(30), e202508366. (www)

  @article{ , abstract = {Microenvironmental engineering of electrocatalysts is pivotal for directing reaction pathways and stabilizing key intermediates in CO 2 reduction reaction (CO 2 RR) to multicarbon products, but it has yet to meet the industrial requirement for selectively producing a most desired product, such as ethylene or ethanol, at a steady above-ampere current level. Herein, a topotactic conversion cum covalent functionalization strategy is invoked to craft a catalyst with confined and modulated surfaces that can bias the reaction heavily for ethylene production with a 22-fold boost in the ethylene/ethanol ratio. The well-tuned covalent structural motif of ─Si─O─Cu─ on PDMS-Cu 2 O/C dramatically elevates the C 2 H 4 -forming activity with a faradaic efficiency reaching up to 71% and a high partial current density of 513.6 mA cm −2 . Operando infrared spectroscopy and density functional theory calculations unveil the ultralow coordination number and the upshifted d-band center. Notably, modulating the d-band center with the covalently elaborated surfaces allows control of the adsorption energies of CHO* and other intermediates along the ethylene path, largely lowering energy barriers for the key steps, particularly the formation of CH 2 CHO*. This work sheds light on the microenvironment modulation at the surface bonding to mesoscopic scales to precisely control catalytic processes and steer reaction pathways toward the target product.}, archive = {J_ANGEW}, author = {Simeng Li and Mingzi Sun and Kai Zhang and Xin Cai and Yanpeng Chen and Chao Yang and Zhi Yang and Xing Tang and Bolong Huang and Shihe Yang}, doi = {10.1002/anie.202508366}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508366}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent elaboration of confined surfaces steers C─C coupling pathway for selective electrochemical CO2 reduction at ampere-level}, volume = {64}, year = {2025}, }
• (2025). Unlocking precision in biomass conversion through functional ligand engineering of lewis acidic MOFs. ANGEW, 64(30), e202508256. (www)

  @article{ , abstract = {Glucose isomerization to fructose is a key factor in cellulosic biomass utilization. Thus, achieving highly efficient fructose production and understanding the dominant reaction route remain crucial goals. Hereby, this study refines a precise ligand engineering strategy applied to the typical metal–organic framework, UiO-66, generating a series of Lewis acidic UiO-66-based catalysts with only subtle structural adjustments. Among all, UiO-66- pCl -SBA possessed the strongest Lewis acidity and the best glucose isomerization performance. Further investigation elaborates the crucial contribution of both Lewis acid amount and specific acid nature to enhanced catalytic reactivity, given a high fructose yield of 47% at glucose conversion of 63%, achieved with a UiO-66-STPA(49%). The increased acid density with specific Lewis acid strength is computationally identified to promote glucose polarization, facilitating the isomerization process. Density functional theory calculations reveal that incorporating functionalized ligands and increasing their proportion markedly decrease both the electron density at Zr sites and the material's band gap, which in turn benefits the Lewis acid strength and catalytic activity enhancement. This work highlights the significance of Lewis sites’ nature and its effect on glucose isomerization performance.}, archive = {J_ANGEW}, author = {Qingchong Xu and Xingjie Wang and Yao Liu and Lihong Zhao and Feng Peng and Junli Ren}, doi = {10.1002/anie.202508256}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508256}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking precision in biomass conversion through functional ligand engineering of lewis acidic MOFs}, volume = {64}, year = {2025}, }
• (2025). Employment of l-citrulline as an effective molecular bridge for regulating the buried interface of perovskite solar cells to achieve high efficiency and good stability. ANGEW, 64(30), e202508169. (www)

  @article{ , abstract = {Suppressing the defects from SnO 2 and perovskite interface is essential for the fabrication of large-area n–i–p perovskite solar cells (PSCs) with the needed lifetime and efficiency for commercialization. Here, we report the employment of l -citrulline (CIT), which has amino acid (─COOH, ─NH 2 ) and urea (─NH─CO─NH 2 ) groups, during SnO 2 colloidal dispersion to function as a molecular bridge to modulate the SnO 2 /perovskite buried interface. The amino acid group can effectively coordinate with Sn 4+ to passivate the oxygen vacancy defects of SnO 2 , and the urea group can interact with uncoordinated Pb 2+ and I − . These interactions not only improve the electron mobility of SnO 2 but also facilitate the formation of larger grain-size perovskite film. In addition, they can also inhibit the generation of excess PbI 2 and the nonphotoactive δ phase to result in suppressed trap-assisted nonradiative recombination. Consequently, the incorporation of CIT helps achieve a champion power conversion efficiency (PCE) of 25.95% (0.07065 cm 2 ) in PSC with improved shelf life/light soaking stability. When combined with an antisolvent-free slot-die coating technique in air, the solar modules (23.26 cm 2 ) could achieve a PCE of 22.70%, which is among the highest PCE reported so far.}, archive = {J_ANGEW}, author = {ChaoBo Hao and Ruoyao Xu and Boyang Li and Yi Chen and QingYu Jia and ZhiQiang Wang and JiangXue Pei and BoHua Zhang and Yaqiong Su and Jingrui Li and Hua Dong and ZhaoXin Wu and Alex K.-Y. Jen and DongDong Wang}, doi = {10.1002/anie.202508169}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Employment of l-citrulline as an effective molecular bridge for regulating the buried interface of perovskite solar cells to achieve high efficiency and good stability}, volume = {64}, year = {2025}, }
• (2025). Synergistic effects of nitrogen and oxygen active sites in covalent organic frameworks for highly efficient gold recovery. ANGEW, 64(30), e202508162. (www)

  @article{ , abstract = {Developing efficient adsorbents for precious metals, especially gold recovery, necessitates the integration of multiple critical properties, including high adsorption capacity, rapid adsorption kinetics, and exceptional selectivity, posing significant scientific challenges with substantial economic and environmental implications. Herein, we report a strategy to achieve highly efficient gold adsorption through synergistic effects of nitrogen and oxygen active sites into covalent organic frameworks (COFs). Two β-ketoenamine-linked COFs (NKCOF-77 and -78) with high-density nitrogen/oxygen active sites are rationally designed and synthesized via a Michael addition-elimination reaction approach. Notably, the comprehensive gold recovery performance for NKCOF-77 is among the best in the COF field, with the third highest adsorption capacity (up to 3225 mg g −1 ), ultrafast adsorption kinetics (<5 min), and near-perfect selectivity (>99.9% with 10 competitive cations and anions). Moreover, the COFs show exceptional ability for gold recovery from real e-waste solutions, demonstrating tremendous practical application potential. Various experimental characterization and density functional theory calculations reveal that strategically incorporating high-density nitrogen and oxygen active sites is crucial in significantly enhancing the gold adsorption capacity. This work provides a novel strategy for designing COFs as precious metal adsorbents, highlighting their promising potential for industrial applications.}, archive = {J_ANGEW}, author = {Xueling Qiao and Liqin Hao and Hongxia Ren and En Lin and Jixian Wang and Kaiyuan Wang and Peng Cheng and Yao Chen and Zhenjie Zhang}, doi = {10.1002/anie.202508162}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic effects of nitrogen and oxygen active sites in covalent organic frameworks for highly efficient gold recovery}, volume = {64}, year = {2025}, }
• (2025). Structural origin of spin-orbit splitting of 1P orbitals of icosahedral au13 superatom protected by ligands. ANGEW, 64(30), e202508151. (www)

  @article{ , abstract = {The key structural factors underlying the spin-orbit (SO) splitting of the 1P orbitals in thiolate-protected Au 13 superatoms were investigated using cryogenic anion photoelectron spectroscopy (PES) and two-component density functional theory (2c-DFT) calculations. PES revealed that the 1P orbitals of the Au 13 and Au@Ag 12 superatomic cores undergo splitting, whereas those of the Ag 13 core do not. According to 2c-DFT calculations, the SO splitting of the 1P orbitals of the Au 13 superatom stems from the symmetry-dictated coupling between the 6p orbitals of the central Au atom and the 1P orbitals formed by the surrounding icosahedral Au 12 shell, both of which are split by SO effects.}, archive = {J_ANGEW}, author = {Shun Ito and Kiichirou Koyasu and Tatsuya Tsukuda}, doi = {10.1002/anie.202508151}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural origin of spin-orbit splitting of 1P orbitals of icosahedral au13 superatom protected by ligands}, volume = {64}, year = {2025}, }
• (2025). Al3+-dependent anisotropic facet tailoring on SrTiO3 single crystal for photocatalytic overall water splitting. ANGEW, 64(30), e202508114. (www)

  @article{ , abstract = {Controllable fabrication of single-crystal metal oxide is of paramount importance for advanced photo(electro)catalytic applications, but achieving nonequilibrium crystal shapes with tailored facets through molten salt synthesis still remains a challenge. Herein, we systematically explored the effect of Al 3+ concentration in tailoring crystal facets of SrTiO 3 single crystals and developed a one-step molten salt strategy for engineering anisotropic structures by using miscible AlCl 3 as Al 3+ additive. By progressively increasing Al 3+ concentration, a series of high-quality SrTiO 3 single crystals exposing {100}, {111}, and {110} facets were sequentially synthesized. Theoretical calculations reveal an Al-doping stabilized {111} surface reconstruction and provide further atomistic insights into the surface structural evolution with Wulff constructions as Al 3+ concentration increases. Experimental results demonstrate that the anisotropic facets dominate the efficient charge separation for the enhanced photocatalytic overall water splitting activity. Consequently, SrTiO 3 single crystals enclosed by well-defined {100} and {111} facets exhibit a remarkable hydrogen evolution rate of 2621.85 µmol·h −1 and an apparent quantum yield value of 50.5% at 350 nm for stoichiometric overall water splitting. This work offers a molten-salt synthetic strategy and valuable insight for preparing facet-controlled single-crystal semiconductors.}, archive = {J_ANGEW}, author = {Yang Zhang and Zhi-Hao Wang and Wenbo Li and Peng Cheng Ding and Meng Min Wang and Yu Yang Tang and Hao Yang Lin and Yu Peng and Meng Yi Wang and Zhaoke Zheng and Shuang Yang and Sheng Dai and Xie Zhang and Peng Fei Liu and Hua Gui Yang}, doi = {10.1002/anie.202508114}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Al3+-dependent anisotropic facet tailoring on SrTiO3 single crystal for photocatalytic overall water splitting}, volume = {64}, year = {2025}, }
• (2025). Supramolecular chalcogen-bonded shape memory actuators. ANGEW, 64(30), e202508101. (www)

  @article{ , abstract = {Supramolecular liquid crystal elastomers (LCEs) incorporating chalcogen bonds (ChBs) have been synthesized and investigated for shape memory and actuation properties. LCEs featuring strong Se⋯N ChBs (−40 to −43 kJ mol −1 ) exhibit both shape memory effects (SME) and reversible actuation, while those with weaker S⋯N ChBs (−32 to −34 kJ mol −1 ) do not. The Se⋯N-based LCEs transition from one-way to two-way SME after three days at room temperature, enabling programmable 2D/3D shape transformations and rewritable surface patterns. They also enable the fabrication of light-powered crawling robots as well as temperature-responsive knot-like actuators. These results highlight the critical role of the ChB strength and specificity in designing functional materials. Solid-state NMR, Raman spectroscopy, and density functional theory calculations provide further molecular-level insights into ChB interactions, laying the groundwork for advanced supramolecular actuators and shape-morphing LCEs.}, archive = {J_ANGEW}, author = {Hongshuang Guo and J. Mikko Rautiainen and Hao Zeng and Kari Rissanen and Arri Priimagi and Rakesh Puttreddy}, doi = {10.1002/anie.202508101}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202508101}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular chalcogen-bonded shape memory actuators}, volume = {64}, year = {2025}, }
• (2025). A universal P-type heterointerface for inverted perovskite solar cells. ANGEW, 64(30), e202507950. (www)

  @article{ , abstract = {Inverted perovskite solar cells with self-assembled monolayers (SAMs) have attracted extensive attention due to their high efficiency and long-term operational stability. However, the hole extraction at the SAMs/perovskite interface is generally less efficient with respect to the electron extraction. Here, we report the construction of a universal p-type heterointerface between SAMs and perovskite with heterocyclic dipolar compounds imidazole hydroiodide (ImHI). We found that the strong interaction by hydrogen bonds together with formative dipole layer were observed between ImHI and perovskite. This allows more p-type contacts with relatively small energy barriers at SAMs/perovskite heterointerfaces by downshifting the Fermi level, reducing the energy mismatch and facilitating the hole extraction. The p-type contact enhancement was further confirmed by a series of SAMs at the perovskite buried interface. As a result, a best-performing solar cell with a power conversion efficiency of 26.05% was achieved, with maintaining 96% of the initial efficiency for 2000 h under nitrogen-filled glove box, 94% of the initial efficiency for 800 h at 55 °C/55% RH, and 86% of the initial efficiency for 1000 h under continuous light stress at maximum power point.}, archive = {J_ANGEW}, author = {Biyun Ren and Tengfei Pan and Zihan Gu and Xiaorong Shi and Xueqin Ran and Wan Yang and Meiru Duan and Yuqian Xie and Yue Wang and He Dong and Kui Xu and Zhengyi Sun and Yingdong Xia and Zhongan Li and Xingyu Gao and Lingfeng Chao and Yonghua Chen}, doi = {10.1002/anie.202507950}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507950}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A universal P-type heterointerface for inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Ultraselective permeable polyamide membranes prepared via interfacial polymerization of alkane and deep eutectic solvent. ANGEW, 64(30), e202507932. (www)

  @article{ , abstract = {Conventional alkane/water interfacial polymerization encounters significant challenges in constructing polyamide membranes with precise nanoconfinement. This requires advanced strategies that simultaneously slow the diffusion kinetics and suppress side reactions, facilitating the formation of a well-defined pore architecture. Herein, we introduced an alkane/deep eutectic solvent (DES) interfacial polymerization approach, allowing the preparation of ultraselective permeable polyamide membranes. The DES, acting as an anhydrous solvent, effectively prevents side reactions, while its robust hydrogen bonding network finely regulates the diffusion behavior of amine monomers and induces the assembly of oligomers, affording a polyamide membrane with uniform subnanometer pores. Notably, the strong hydrogen bonding network of DES enhances the solvation of amine monomers, which further promotes the tuning of the membrane structures and functions. The polyamide membrane produced using specific DES (D-PA) revealed an exceptional NaCl/Na 2 SO 4 (165.8) separation selectivity, an order of magnitude larger than that of conventional polyamide membranes, coupled with impressive water permeance of up to 18.4 L m −2 h −1 bar −1 . This strategy offers a paradigm shift in the fabrication of ultraselective permeable polyamide membranes for advanced water purification system.}, archive = {J_ANGEW}, author = {Jiansong Liu and Yang Yang and Shuai Gu and Jianghua Li and Feiping Zhao and Guipeng Yu and Kam C. Tam and Juntao Tang}, doi = {10.1002/anie.202507932}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultraselective permeable polyamide membranes prepared via interfacial polymerization of alkane and deep eutectic solvent}, volume = {64}, year = {2025}, }
• (2025). Dual-responsive ultrathin polymersomes with reversible transitions on acidochromism and fluorochromism performances for multiple information encryption. ANGEW, 64(30), e202507852. (www)

  @article{ , abstract = {Endowing dual-responsive ultrathin polymersomes (UTPSs) with reversible stimuli-chromic and fluorochromic performances offers a prospective yet challenging strategy for achieving high-level information encryption and anticounterfeiting. Herein, starting from rational synthesis of visible light/pH-responsive integrated azobenzene monomer, side-chain-type amphiphilic alternating azocopolymers were elaborately crafted using a moderate epoxy-amino click-polycondensation. Followed by subsequent solution self-assembly, dual-responsive UTPSs with a diameter of ∼253 nm and a vesicular thickness of ∼2.1 nm were subtly produced based on the pendant hydrophobic conjugate stacking mechanism. The photoisomerization of azobenzene units and protonation of tertiary amines within UTPSs were accountable for the visible-light- or pH-triggered reversible shape and physicochemical transitions (i.e., color, size, diameter, vesicular thickness, zeta potential, fluorescent intensity) as well as repeatable acidochromism from yellow to pink and recyclable fluorochromism, respectively. Benefiting from these attractive traits, the proof-of-concept 2D quick response code was meticulously crafted using the stimuli-chromic UTPSs into patterning lithography, showcasing a multilevel decryption, favorable reversibility, and preferable recyclability for advanced information security. Our work provides innovative guidelines for the development of dual-responsive UTPSs with multiple stimuli-chromism merits for the potential of complex information encryption.}, archive = {J_ANGEW}, author = {Zichao Sun and Zejiang Xu and Pengchao Wu and Liquan Wang and Mingyu Ding and Lin Zhao and Yongli Zheng and Yongfeng Zhou and Shaoliang Lin and Haibao Jin}, doi = {10.1002/anie.202507852}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507852}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-responsive ultrathin polymersomes with reversible transitions on acidochromism and fluorochromism performances for multiple information encryption}, volume = {64}, year = {2025}, }
• (2025). H2S donor functionalized molecular machine for combating multidrug-resistant bacteria infected chronic wounds. ANGEW, 64(30), e202507833. (www)

  @article{ , abstract = {Chronic wounds are a worldwide medical challenge due to the complex and multifaceted etiologies, including bacterial infection, persistent inflammation, and impaired angiogenesis. Developing a comprehensive strategy integrating antibiosis and anti-inflammation to promote revascularization and accelerate wound healing is highly desirable. Nevertheless, current therapeutic methods still face two major challenges: 1) how to combat bacterial drug resistance, 2) how to achieve spatiotemporal control over bacterial elimination and inflammation reduction. To address these issues, a novel H 2 S donor functionalized molecular machine (MM), ACR-DM-HS, was developed. It selectively binds to and disturbs the bacterial membrane through a light-active vibronic-driven mechanochemical action (VDA), which synergizes with photodynamic therapy (PDT) to efficiently eradicate multidrug-resistant bacteria and biofilms, and conquers the evolution of bacterial resistance. Furthermore, it releases H 2 S in infected tissues to scavenge excess reactive oxygen species (ROS), inhibit the secretion of inflammatory factors, promote angiogenesis, and accelerate the healing of diabetic wounds in vivo. This work provides an integrated strategy combining antibiotics and anti-inflammation to treat with multidrug resistance bacterial-infected chronic wounds.}, archive = {J_ANGEW}, author = {Yuan Chen and Kun-Mei Liu and Ling-Xiao Zhou and Jin-Yu An and Shun Feng and Ming-Yu Wu and Xiao-Qi Yu}, doi = {10.1002/anie.202507833}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507833}, shortjournal = {Angew. Chem. Int. Edit.}, title = {H2S donor functionalized molecular machine for combating multidrug-resistant bacteria infected chronic wounds}, volume = {64}, year = {2025}, }
• (2025). Organocatalytic asymmetric cycloaddition for the construction of chiral indole-fused medium- and large-sized rings. ANGEW, 64(30), e202507804. (www)

  @article{ , abstract = {Catalytic asymmetric construction of chiral indole-fused medium- and large-sized rings represents an important issue in synthetic chemistry but with significant challenges. To overcome these challenges, herein, we report highly enantioselective synthesis of chiral indole-fused medium- and large-sized rings via organocatalytic asymmetric (4 + 4) and (4 + 4 + m) cycloadditions of 2-indolylacetates with benzofuranyl azadienes, providing an efficient strategy for accessing these enantioenriched frameworks. By designing 2-indolylacetates as a new class of four-carbon platform molecules for higher-order cycloadditions and modulating the nucleophilicity of benzofuranyl azadienes, we achieved the catalytic asymmetric synthesis of chiral indole-fused eight-membered rings and eleven- to fourteen-membered macrocycles in high yields with good enantioselectivity. This work not only demonstrates the first application of 2-indolylacetates as four-carbon platform molecules in cycloaddition reactions, but also represents the first catalytic asymmetric (4 + 4) and (4 + 4 + m) cycloadditions of 2-indolylacetates. Furthermore, biological evaluation revealed that several chiral indole derivatives exhibit some extent of antitumor activity, indicating their potential applications in medicinal chemistry.}, archive = {J_ANGEW}, author = {Bo-Wen Lai and Hao-Hui Zhang and Bo-Xuan Yao and Rui Li and Shao-Fei Ni and Kuiyong Dong and Feng Shi}, doi = {10.1002/anie.202507804}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507804}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organocatalytic asymmetric cycloaddition for the construction of chiral indole-fused medium- and large-sized rings}, volume = {64}, year = {2025}, }
• (2025). Rapid access to an enantioenriched spiro bisindole directly from indole and acetone. ANGEW, 64(30), e202507798. (www)

  @article{ , abstract = {Disclosed here is a “one-pot self-assembly” strategy for the enantioselective synthesis of a spiro bisindole molecule directly from indole and acetone. This convenient synthesis contrasts drastically to the typical long sequence required for other privileged C 2 -symmetric spirocycles. The use of an alcohol additive in cooperation with chiral phosphoric acid (CPA) catalysis proved crucial to the good efficiency and enantioselectivity. The favorable interaction between the additive and CPA was confirmed by nuclear magnetic resonance (NMR) and density functional theory (DFT) studies. The obtained enantiopure C 2 -symmetric bisindole was demonstrated as a useful backbone of chiral catalysts/ligands.}, archive = {J_ANGEW}, author = {Jing-Yi Wang and Jie Lin and Chaoshen Zhang and Jianwei Sun}, doi = {10.1002/anie.202507798}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507798}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid access to an enantioenriched spiro bisindole directly from indole and acetone}, volume = {64}, year = {2025}, }
• (2025). Enantioconvergent synthesis of α-fluoroalkyl alcohols enabled by photocatalytic radical brook rearrangement. ANGEW, 64(30), e202507789. (www)

  @article{ , abstract = {While radical Brook rearrangement has emerged as a powerful strategy in modern organic synthesis, enantioselective cross coupling involving radical Brook rearrangement remains unexplored. Herein, we report a photocatalytic radical Brook rearrangement followed by cross-coupling with aryl/heteroaryl bromides, enabling the enantioconvergent construction of chiral α-fluoroalkyl alcohols. Key to this transformation is a radical relay process involving sequential generation of aryl cation radicals, alkoxy radicals, and carbon-centered radicals through Brook rearrangement. The reaction exhibits exceptional scope (>40 examples), outstanding enantiocontrol (up to 99% ee), and broad functional group tolerance. The synthetic utility is demonstrated through formal syntheses of bioactive Odanacatib and LX-1031, along with diverse downstream derivatizations.}, archive = {J_ANGEW}, author = {Yunhong Niu and Chenyu Jin and Xiaoqian He and Shenna Deng and Gang Zhou and Shanshan Liu and Xiao Shen}, doi = {10.1002/anie.202507789}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507789}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioconvergent synthesis of α-fluoroalkyl alcohols enabled by photocatalytic radical brook rearrangement}, volume = {64}, year = {2025}, }
• (2025). Intermediate layer-engineered lanthanide nanoparticles enable deep bioorthogonal liver tumor and vascular imaging via switchable NIR-II emissions. ANGEW, 64(30), e202507787. (www)

  @article{ , abstract = {The second near-infrared window (NIR-II) has become an attractive optical region for fluorescence imaging. However, due to the complexity in vivo, NIR-II light with various wavelengths for different imaging scenes has not been investigated. Here, we found that 1525 nm light is suitable for high-resolution fluorescence imaging due to low background interference, while its attenuation in vivo makes it unsuitable for deep imaging. The 1064 nm light is suitable for deep imaging. The impact of Yb 3+ ions and the proportion of the intermediate layer in lanthanide nanoparticles on the modulation of emissions were investigated. The intense 1064 nm emission is achievable when the Yb 3+ content is 80% and the intermediate layer proportion is 0.1. The bioorthogonal orthotopic liver tumor imaging could be achieved by modifying the lanthanide nanoparticles with DBCO-PEG 2000 -DSPE and establishing artificial receptors by N-azidoacetylmannosamine-tetraacylated (Ac 4 ManNAz). Lanthanide nanoparticles with the intermediate layer proportion of 0.66 and 80% Yb 3+ facilitate intense 1525 nm emission, enabling the vascular imaging. Based on the imaging characteristics of NIR-II emissions with different wavelengths in vivo, this work achieves high-resolution imaging and deep imaging through intermediate layer regulation of lanthanide nanoparticles, providing an opportunity to explore a new generation of high-performance fluorescent probes.}, archive = {J_ANGEW}, author = {Kehong Lv and Hongxia Yue and Chunyan Li and Shengzhe Chen and Hongli Wang and Ruohao Zhang and Jing Feng and Hongjie Zhang}, doi = {10.1002/anie.202507787}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507787}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intermediate layer-engineered lanthanide nanoparticles enable deep bioorthogonal liver tumor and vascular imaging via switchable NIR-II emissions}, volume = {64}, year = {2025}, }
• (2025). Shaping of a reactive manganese catalyst enables access to polyfunctionalized cyclohexanes via enantioselective C(sp3)─H bond oxidation of 1,3-meso diethers. ANGEW, 64(30), e202507755. (www)

  @article{ , abstract = {Chiral polyoxygenated cyclohexanes are valuable constituents of biologically relevant products. Herein, we report a protocol for the direct access to these scaffolds via site- and enantioselective non-directed oxidation of cyclohexyl-3,5- meso diethers using aqueous H₂O₂. Structural shaping of a highly reactive chiral Mn-oxo species, achieved through the combination of a sterically encumbered ligand and a bulky carboxylic acid, promotes a precise fit of the substrate within the catalyst pocket, which translates into exceptional enantioselectivity (up to >99% ee). Computational studies reveal that C─H oxidation proceeds via an initial hydrogen atom transfer, followed by electron transfer, leading to the formation of a chiral cationic intermediate. The resulting desymmetrized 3-methoxycyclohexanone products serve as valuable intermediates for the synthesis of bioactive cores, as they can undergo orthogonal chemical modifications to enable further structural diversification.}, archive = {J_ANGEW}, author = {Andrea Palone and Arnau Call and Aleria Garcia-Roca and Josep M. Luis and Matthew S. Sigman and Massimo Bietti and Cristina Nevado and Miquel Costas}, doi = {10.1002/anie.202507755}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507755}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Shaping of a reactive manganese catalyst enables access to polyfunctionalized cyclohexanes via enantioselective C(sp3)─H bond oxidation of 1,3-meso diethers}, volume = {64}, year = {2025}, }
• (2025). In situ solid conversion into mechanically adaptive LiF-rich solid electrolyte interphase via MgF2 precursor on si surface in lithium-ion batteries. ANGEW, 64(30), e202507688. (www)

  @article{ , abstract = {Silicon (Si) anodes hold exceptional promise for high-energy-density lithium-ion batteries (LIBs) due to their ultrahigh theoretical capacity (∼4200 mAh g⁻¹). However, their commercialization is severely hindered by the significant volume expansion (∼300%) and unstable solid electrolyte interphase (SEI). Conventional SEI, predominantly composed of organic species, suffers from low ionic conductivity, low electronic insulation, and poor mechanical robustness, leading to rapid capacity decay. Herein, we propose an interface engineering strategy by decorating Si nanoparticles with an in situ conversed MgF 2 layer (with coating integrity of 94.2%). During initial lithiation, the applied MgF 2 layer is in situ conversed into SEI film with high ionic conductivity, electronic insulation, and better mechanical adaptability. The prepared Si@MgF 2 -1 anode achieves a high initial coulombic efficiency (91.7%), superior rate capability (2000 mAh g⁻¹ at 10 C), and remarkable cycling stability (1794.9 mAh g −1 after 500 cycles). Full-cell based on the Si@MgF 2 -1 anode and NCM811 cathode further validate the practicality of this approach. The robust conversion strategy for the construction of a mechanically adaptive LiF-rich SEI layer holds significant promise for the advancement of durable silicon-based LIBs.}, archive = {J_ANGEW}, author = {Jiayang Sun and Linze Lv and Yuchen Li and Yan Wang and Longfei Wang and Weixing Xiong and Lei Huang and Qunting Qu and Honghe Zheng}, doi = {10.1002/anie.202507688}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507688}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ solid conversion into mechanically adaptive LiF-rich solid electrolyte interphase via MgF2 precursor on si surface in lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Blocky selective postpolymerization C–H functionalization of polyolefins. ANGEW, 64(30), e202507687. (www)

  @article{ , abstract = {C–H functionalization of commodity polyolefins affords functional materials derived from a high-volume, low-cost resource. However, current postpolymerization modification strategies result in randomly distributed functionalization along the length of the polymer backbone, which has a negative impact on the crystallinity of the resultant polymers, and thus the thermomechanical properties. Here, we demonstrate an amidyl radical mediated C–H functionalization of polyolefins to access blocky microstructures, which exhibit a higher crystalline fraction, larger crystallite size, and improved mechanical properties compared to their randomly functionalized analogues. Taking inspiration from the site-selective C–H functionalization of small molecules, we leverage the steric protection provided by crystallites and target polymer functionalization to amorphous domains in a semicrystalline polyolefin gel. The beneficial outcomes of blocky functionalization are independent of the identity of the pendant functional group that is installed through functionalization. The decoupling of functional group incorporation and crystallinity highlights the promise in accessing nonrandom microstructures through selective functionalization to circumvent traditional tradeoffs in postpolymerization modification, with potential impact in advanced materials and upcycling plastic waste.}, archive = {J_ANGEW}, author = {Eliza K. Neidhart and Michelle E. Pomatto and Chris Vasallo and Erin R. Crater and Jill W. Alty and Polyxeni P. Angelopoulou and Erik J. Alexanian and Logan T. Kearney and Robert B. Moore and Frank A. Leibfarth}, doi = {10.1002/anie.202507687}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507687}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Blocky selective postpolymerization C–H functionalization of polyolefins}, volume = {64}, year = {2025}, }
• (2025). Enantioselective divergent total syntheses of cycloaurenones and dysiherbols. ANGEW, 64(30), e202507638. (www)

  @article{ , abstract = {Cycloaurenones and dysiherbols are naturally occurring sesquiterpene quinones/quinols that share a 6/6/5/6 tetracyclic carbon skeleton with either a cis - or trans -decalin system containing four contiguous stereocenters, including three contiguous all-carbon quaternary stereocenters. Total syntheses of cycloaurenones have not been reported. Herein, we present the first enantiodivergent syntheses of cycloaurenones and dysiherbols based on manipulation of a common cyclohexadienone intermediate: namely, a local desymmetric Giese–Baran-type cyclization for cycloaurenones and a copper-catalyzed enantioselective conjugate addition for dysiherbols. Moreover, the key cyclohexadienone intermediate was readily accessible by a bidirectional approach from a chiral bis-Weinreb amide. The 1,4-nonadjacent stereocenters were installed by an unprecedented enantioselective hydrogenation of the corresponding bis-α,β-unsaturated Weinreb amide (>99:1 chiral/ meso ratio, >99% enantiomeric excess).}, archive = {J_ANGEW}, author = {Yu-Hao Huang and Qing-Xiu Gu and Qing-Cen Chao and Han-Zhi Xiao and Hai-Hua Lu}, doi = {10.1002/anie.202507638}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507638}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective divergent total syntheses of cycloaurenones and dysiherbols}, volume = {64}, year = {2025}, }
• (2025). Supramolecularly confined catalysis in polyphthalocyanine-crown-ether frameworks boosts sulfur redox kinetics. ANGEW, 64(30), e202507612. (www)

  @article{ , abstract = {Metal phthalocyanines are considered as potent catalysts in lithium–sulfur (Li–S) chemistry. However, their adsorption capability is deficient to inhibit polysulfides from shuttling, which in turn retards the S-redox reaction in the cathode. Here we report flexible, two-dimensional (2D) polyphthalocyanine-crown-ether (PPc-CE) frameworks that provide a supramolecularly confined space created with the single-atom catalytic nickel phthalocyanine nodes and crown-ether linkers as Li host. Electrochemical and theoretical analyses reveal that a cooperative redox catalysis with the enhanced lithiophilicity of PPc-CE-coated carbon nanotubes (PPc-CE/CNTs) boosts Li–S redox kinetics and, meanwhile, suppresses the growth of Li dendrites for the long term. A Li||S cell employing PPc-CE/CNT catalysts delivers a high discharge capacity of 1,363 mAh g −1 at 0.1C and still retains a specific capacity of ∼700 mAh g −1 over 500 cycles at 1C. Our work provides insights into the molecular design of redox catalysts for Li–S batteries based on 2D polymers.}, archive = {J_ANGEW}, author = {Xinming Zhang and Qing-Xuan Chen and Wentao Zhang and Hongyin Hu and Huimin Wu and Zhaotian Xie and Xin He and Yilin Niu and Xianming Deng and Li Liu and Zhenghua Zhang and Lele Peng and Zhen Chen}, doi = {10.1002/anie.202507612}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507612}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecularly confined catalysis in polyphthalocyanine-crown-ether frameworks boosts sulfur redox kinetics}, volume = {64}, year = {2025}, }
• (2025). Deciphering coulombic efficiency of lithium metal anodes by screening electrolyte properties. ANGEW, 64(30), e202507387. (www)

  @article{ , abstract = {Coulombic efficiency (CE) is a quantifiable indicator for the reversibility of lithium metal anodes in high-energy-density batteries. However, the quantitative relationship between CE and electrolyte properties has yet to be established, impeding rational electrolyte design. Herein, an interpretable model for estimating CE based on data-driven insights of electrolyte properties is proposed. Hydrogen-bond acceptor basicity ( β ) and the energy level gap between the lowest unoccupied and the highest occupied molecular orbital (HOMO-LUMO gap) of solvents are identified as the top two parameters impacting CE by machine learning. β and HOMO-LUMO gap of solvents govern anode interphase chemistry. A regression model is further proposed to estimate the CE based on β and HOMO-LUMO gap. Using the new solvent screened by above regression model, the lithium metal anode in the pouch cell with an energy density of 418 Wh kg −1 achieves the highest CE of 99.2%, which is much larger than previous CE ranging from 70%–98.5%. This work provides a reliable interpretable quantitative model for rational electrolyte design.}, archive = {J_ANGEW}, author = {Zhao Zheng and Xinyan Liu and Xue-Qiang Zhang and Shu-Yu Sun and Jia-Lin Li and Ya-Nan Wang and Nan Yao and Dong-Hao Zhan and Wen-Jun Feng and Hong-Jie Peng and Jiang-Kui Hu and Jia-Qi Huang and Qiang Zhang}, doi = {10.1002/anie.202507387}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507387}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering coulombic efficiency of lithium metal anodes by screening electrolyte properties}, volume = {64}, year = {2025}, }
• (2025). Switchable regiodivergent reductive Alkyl–Alkyl coupling by nickel catalysis: Sorting different Alkyl–Nickel intermediates. ANGEW, 64(30), e202507313. (www)

  @article{ , abstract = {Site-selective and divergent functionalizations on saturated alkyl chain at specific unfunctionalized positions is a key challenge in organic chemistry and other related areas and offers unprecedented synthetic opportunities. Herein, a ligand-controlled Ni-catalyzed site-selective and divergent alkyl–alkyl reductive coupling between two different alkyl halides has been developed. Notably, the reaction finely tunes and recognizes thermodynamic favored α-aminoalkyl radicals over β-aminoalkyl radicals, and distal ipso -alkyl radicals to deliver chemo- and position-selective alkylation of unactivated α-H and β-H of amines under reductive conditions. Moreover, the reaction selectively functionalizes one alkyl chain over two migratable alkyl chains. By just switching the catalytic parameters, α- and β-alkylation of saturated C─H bonds, and ipso -alkyl-alkyl coupling allow for rapid access to three types of branched aliphatic amine architectures from identical starting materials.}, archive = {J_ANGEW}, author = {Quan-Xing Zi and Lin Min and Hai-Wu Du and Qiong Yu and Yu-Long Li and Wei Shu}, doi = {10.1002/anie.202507313}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507313}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switchable regiodivergent reductive Alkyl–Alkyl coupling by nickel catalysis: Sorting different Alkyl–Nickel intermediates}, volume = {64}, year = {2025}, }
• (2025). Atomic Cu–O–Zr sites for highly selective production of p-xylene from tandem upcycling of PET and CO2. ANGEW, 64(30), e202507309. (www)

  @article{ , abstract = {Exploring an efficient catalytic system for tandem upcycling of CO 2 and polyethylene terephthalate (PET) is highly desirable for achieving efficient resource utilization of wastes. However, the high activation energy for C═O bonds (in both PET and CO 2 ) and the difficulty in regulating the reaction pathways restricted PET recovery efficiency. Here, we demonstrated the rational design of a single-atom Cu catalyst for precisely catalyzing the hydrogenation of CO 2 to methanol and tandem PET upcycling to ethylene glycol (EG) and p -xylene (PX). In the Cu/UiO-66-NH 2 -A catalyst, Cu atoms are selectively anchored to the Zr-oxo nodes of UiO-66-NH 2 to form Cu–O–Zr sites. The Cu–O–Zr sites can effectively activate both CO 2 and H 2 by reducing the activation energy and accelerate the transformation of PET to dimethyl terephthalate (DMT), which is further hydro-deoxygenated to yield PX. As a result, 20.4% CO 2 conversion was obtained within 36 h, with 89.5% and 92.1% yields of PX and EG, respectively. Rapid and precise hydrogen spillover from Cu atoms to adsorbed reactants/intermediates at the Cu–O–Zr sites also drives the reaction process.}, archive = {J_ANGEW}, author = {Qizhuang Zou and Tairen Long and Ruiqi Fang and Xin Zhao and Fengliang Wang and Yingwei Li}, doi = {10.1002/anie.202507309}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507309}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic Cu–O–Zr sites for highly selective production of p-xylene from tandem upcycling of PET and CO2}, volume = {64}, year = {2025}, }
• (2025). Leveraging sortase a electrostatics for powerful transpeptidation reactions. ANGEW, 64(30), e202507236. (www)

  @article{ , abstract = {Sortase-mediated transpeptidation is a powerful biochemical reaction to perform protein engineering. In this work, we leverage the unique electrostatic profile of sortase A pentamutant (SrtA-5M) to improve SrtA-5M-mediated transpeptidations by incorporating short, charged peptidic modules into the substrates. Importantly, the reaction proceeds with a minimal excess of nucleophile and is fast and highly efficient in the low micromolar substrate concentration range. Electrostatic assistance eliminates the need for additives or complex substrate engineering strategies, thereby giving it a broad scope. Our findings also provide fundamental insights into the influence of substrate charge on SrtA-5M activity, paving the way for further optimization of sortase A-catalyzed transpeptidation reactions.}, archive = {J_ANGEW}, author = {Chen Wang and Rémi Desmet and Benoît Snella and Jérôme Vicogne and Oleg Melnyk and Vangelis Agouridas}, doi = {10.1002/anie.202507236}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507236}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging sortase a electrostatics for powerful transpeptidation reactions}, volume = {64}, year = {2025}, }
• (2025). Type I-B main-chain polyrotaxane network. ANGEW, 64(30), e202507192. (www)

  @article{ , abstract = {Polyrotaxanes (PRs) are recognized for their outstanding conformational flexibility, making them ideal candidates for the design of high-performance mechanically interlocked materials. However, Type I-B main-chain PRs, featuring multiple wheels and stoppers along the polymer backbone, remain underexplored due to the challenges in their design and synthesis. Herein, we introduce a facile “host−guest recognition followed by click polymerization” strategy for the synthesis of Type I-B main-chain PR, which is subsequently employed to prepare the first-ever Type I-B main-chain PR network (PRN). Compared to the control whose wheels are nonslidable under applied force, the distinctive dynamic behaviors of Type I-B main-chain PR impart extraordinary mechanical enhancements to PRN, with fracture strain, toughness, and puncture resistance all surging by more than 27-fold. Moreover, the combination of the host−guest recognition and multiple stoppers endows the PRN with great self-recovery capability due to the restriction of the motion range of mechanical bonds. This work not only presents a novel strategy for designing and synthesizing Type I-B main-chain PR networks but also highlights the pivotal role of Type I-B main-chain PRs in enhancing material performance, offering valuable insights for advancing the development of dynamic polymer materials.}, archive = {J_ANGEW}, author = {Wenbin Wang and Ruixue Bai and Chunyu Wang and Li Yang and Lin Cheng and Zhaoming Zhang and Wei Yu and Xuzhou Yan}, doi = {10.1002/anie.202507192}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507192}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Type I-B main-chain polyrotaxane network}, volume = {64}, year = {2025}, }
• (2025). Nonconjugated structural distortion promoting the formation of NIR triplet states in phenothiazine dyes for cancer photoimmunotherapy. ANGEW, 64(30), e202507157. (www)

  @article{ , abstract = {Near-infrared (NIR) triplet-state dyes are pivotal for advanced biomedical and material science applications. Although numerous strategies have been proposed to enhance the photosensitization efficiency of dyes, significant challenges remain. Herein, we propose a novel strategy leveraging nonconjugated structural distortion to enhance triplet-state formation. This strategy, achieved by introducing steric groups at the edges of the phenothiazine (PTZ) dye framework, notably enhances intersystem crossing (ISC) and prolongs triplet-state lifetime. Based on this strategy, HNBS and HNBSe are synthesized, which exhibit exceptional triplet-state quantum yields (47.2% for HNBS and 87.7% for HNBSe) and prolonged triplet-excited-state lifetimes (21.1 µs for HNBS and 6.3 µs for HNBSe). These values substantially exceed those of conventional dyes, such as NBS (negligible and NBSe (3.2 µs). Under ultralow-light doses (0.45 J cm − 2 in vitro, and 6 J cm − 2 in vivo), these photosensitizers demonstrate robust tumor cell inhibition, highlighting their exceptional photosensitizing ability. Mechanistically, HNBS possesses lysosomal-targeting ability, and upon light irradiation, it induces lysosomal damage, triggering pyroptosis and immunogenic cell death. These processes promote dendritic cell maturation and T-cell differentiation, augmenting the immune response and enabling effective photoimmunotherapy.}, archive = {J_ANGEW}, author = {Xiang Xia and Ran Wang and Yingqi Hu and Saran Long and Wen Sun and Jiangli Fan and Xiaojun Peng}, doi = {10.1002/anie.202507157}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507157}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nonconjugated structural distortion promoting the formation of NIR triplet states in phenothiazine dyes for cancer photoimmunotherapy}, volume = {64}, year = {2025}, }
• (2025). Design considerations of ionic conductive elastomeric electrolyte for solid-state zinc metal batteries with high safety and long life. ANGEW, 64(30), e202507137. (www)

  @article{ , abstract = {Zn−ion batteries are regarded as one of the most promising candidates for energy storage, but the severe hydrogen evolution reaction (HER) and dendrite growth have impeded their application. In this study, we developed an Zn 2+ -ionic conductive elastomer solid-state electrolyte through the simultaneous hydrogen-bond cross-linking between phytic acid (PA) molecules and polyvinyl alcohol (PVA). The large PA molecules inside the polymer electrolyte are favorable to maintaining stretched conformation of PVA chain and uniform interpenetrating distribution, enhancing the amorphous region of PVA polymer. And the high-density hydrogen bond network constructed from PVA chains and PA molecules builds a novel transport mode to promote the efficient Zn 2+ ion transport, displaying significant ion conductivity of 6.05 mS cm −1 at 30 °C and a higher transference number of 0.68. The special viscoelasticity of the elastomer facilitates close contact with electrodes, ensuring superior interface compatibility. The assembled Zn symmetric battery exhibits a stable cycle life of 2880 h under 0.5 mA cm −2 /0.5 mAh cm −2 , and the assembled Zn//VO 2 full battery still maintains a capacity retention rate of 86.5% at 400 cycles under 1.0 A g −1 . The development of ionic conductive elastomers offers a novel approach to solve the solid-state interface design of solid-state Zn−ion batteries.}, archive = {J_ANGEW}, author = {Yue Wang and Li-Na Song and Shuang Liang and Jia-Yi Wu and Lu Feng and Xiao-Xue Wang and Ji-Jing Xu}, doi = {10.1002/anie.202507137}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507137}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design considerations of ionic conductive elastomeric electrolyte for solid-state zinc metal batteries with high safety and long life}, volume = {64}, year = {2025}, }
• (2025). Correspondence on “Highly selective electrocatalytic 1,4-NADH regeneration based on Host–Guest recognition mediated by cucurbit[8]uril on NiO”. ANGEW, 64(30), e202507113. (www)

  @article{ , abstract = {Recently, Ning et al., have reported a very interesting and promising electrochemical method of 1,4-NADH regeneration. NAD + forms host–guest complex with the cucurbit[8]uril anchored to the NiO surface, and then NAD + approaches the surface-adsorbed hydrogen atoms on NiO, which leads to the effective 1,4-NADH regeneration. It is reasonable to expect that the method will find practical application in the industrial processes in which 1,4-NADH is employed, lowering their costs. The only part of the article by Ning et al., which seems to be disputable, is the reported mass spectrometry data, sometimes a lack of data, as described in detail in this correspondence.}, archive = {J_ANGEW}, author = {Rafał Frański}, doi = {10.1002/anie.202507113}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507113}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correspondence on “Highly selective electrocatalytic 1,4-NADH regeneration based on Host–Guest recognition mediated by cucurbit[8]uril on NiO”}, volume = {64}, year = {2025}, }
• (2025). Giant negative thermal expansion induced by topological phase transition in a potassium zinc phosphate material. ANGEW, 64(30), e202507107. (www)

  @article{ , abstract = {Negative thermal expansion (NTE) materials exhibit the counterintuitive property of volume contraction upon heating, which is critical for precision engineering applications. While significant progress has been made in NTE material discovery and mechanism understanding, developing cost-effective systems with strong NTE effects remains challenging. Here we report that an economical phosphate material, KZn(PO 3 ) 3 , which demonstrates a record-breaking volumetric contraction (Δ V / V = −11.49%) during its low-temperature to high-temperature phase transition. This exceptional NTE behavior originates from an unprecedented topological phase transition involving structural reorganization from infinite (PO 4 ) ∞ -chains ( C ∞ symmetry) to discrete P 3 O 9 -rings ( C 3 symmetry). The variable-cell nudged elastic band, ab initio molecular dynamics, and self-consistent phonon calculations reveal a threefold mechanism: (1) reduced K–K distance minimize electrostatic repulsion, (2) covalent bond rearrangement enables the chain-to-ring transformation, and (3) pronounced vibrational modes of O1 atoms destabilize the anionic chains, promoting their cleavage. Concurrently, these cooperative effects drive the observed giant NTE, while the resulting hexagonal-closed-packed ( hcp ) K + sublattice further enhances structural contraction.}, archive = {J_ANGEW}, author = {Xin Liu and Yi-Chang Yang and Qian-Qian Liu and Shuang Zhao and Tong Yu and Li-Ming Wu and Ling Chen}, doi = {10.1002/anie.202507107}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507107}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Giant negative thermal expansion induced by topological phase transition in a potassium zinc phosphate material}, volume = {64}, year = {2025}, }
• (2025). Reengineering of a proteomimetic pan-ras inhibitor into a ras degrader. ANGEW, 64(30), e202507092. (www)

  @article{ , abstract = {Bifunctional ligands that can coax protein–protein interactions have become attractive therapeutic modalities. Herein, we describe conformationally defined helix dimers as proteomimetic molecular glues . The helix dimers can be rationally designed to engage helical protein interfaces. We previously described a synthetic Sos protein mimic, CHD SOS , as a Ras ligand that inhibits wild-type and oncogenic Ras signaling. This Sos proteomimetic consisted of a crosslinked helix dimer (CHD) that reproduced two helical domains, termed αH and αI, from Sos. The native αH helix of Sos constitutes the primary contact surface for Sos, while αI has minimal engagement. We conjectured that the αI domain of CHD SOS could be reengineered to preserve Ras binding, while engaging another protein to fully leverage the contact residues available in a proteomimetic. Herein, we incorporate a second distinct binding epitope into CHD SOS , thereby generating a bispecific proteomimetic. This secondary epitope was designed based on the p53 activation domain to engage the E3 ligase MDM2 and induce complexation with Ras. The resulting lead proteomimetic, CHD BI4 , associates with both MDM2 and Ras and demonstrates reduction of cellular Ras levels. Overall, the study offers a proof of concept for the development of a bispecific proteomimetic scaffold to target multiple protein interfaces.}, archive = {J_ANGEW}, author = {Joseph F. Ongkingco and Seong Ho Hong and Eugene D. Toth and Thu Nguyen and Paramjit S. Arora}, doi = {10.1002/anie.202507092}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202507092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reengineering of a proteomimetic pan-ras inhibitor into a ras degrader}, volume = {64}, year = {2025}, }
• (2025). Photoacid-induced supramolecular network disassembly: A systems approach to stimuli-responsive polymers. ANGEW, 64(30), e202506981. (www)

  @article{ , abstract = {The introduction of supramolecular (SM) motifs allows the design of stimuli-responsive polymers whose physical properties can be changed by external triggers that affect the SM binding. However, using this approach to create light-responsive materials that can be switched under isothermal conditions proves to be challenging. Here, we report a material systems approach to achieve this. Thus, SM polymer networks, in which optically inert ureidopyrimidinone (UPy) groups assemble into reversible cross-links, are combined with a trigger molecule, the photoacid generator (PAG) 2-(4-methoxy-styryl)-4,6-bis(trichloromethyl)-1,3,5-triazine (MBTT). Model experiments with a fluorescent, self-reporting UPy motif elucidate the sequence of processes that result from optical triggering, namely acid generation, protonation of UPy groups, and ultimately dissociation of the SM cross-links. The optically stimulated transformation of gels and rubbery films into viscous liquids was quantitatively monitored by opto-rheological measurements, showing that the optical stimulation and resultant mechanical responses are intimately coupled. The potential usefulness of this approach to create materials with spatially graded mechanical characteristics and as the basis for debonding-on-demand (DOD) adhesives was explored in proof-of-concept experiments.}, archive = {J_ANGEW}, author = {Marta Oggioni and Luca Bertossi and Derek J. Kiebala and Adelle Kirshner and Andrea Dodero and Georges J. M. Formon and Christoph Weder}, doi = {10.1002/anie.202506981}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506981}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoacid-induced supramolecular network disassembly: A systems approach to stimuli-responsive polymers}, volume = {64}, year = {2025}, }
• (2025). Unlocking durable and sustainable Zinc–Iodine batteries via molecularly engineered polyiodide reservoirs. ANGEW, 64(30), e202506822. (www)

  @article{ , abstract = {Zinc–iodine batteries (ZIBs) are promising candidates for safe and sustainable energy storage but are hindered by polyiodide shuttling, leading to rapid capacity decay and limited cyclability. In this work, we propose a “polyiodide reservoirs” concept, utilizing iodophilic covalent organic cages to confine polyiodide through multiple noncovalent interactions. By precisely engineering the nitrogen-active site densities around 3D cavities, these cages evolve from open to near-enclosed structure, achieving molecular-level polyiodide entrapment. The optimized superphane cage (18 N-active sites) enables a ZIB with 90.1% capacity retention after 4000 cycles at 5 C, even under extreme conditions (58.9 wt% iodine content within the cage and an iodine area loading of 3.7 mg cm −2 in the cathode). Importantly, the cage's solubility-driven regeneration capability retains 85.4% initial capacity over three reuse cycles. This work establishes covalent organic superphanes as a transformative platform for long-life ZIBs, offering a dual solution to shuttle suppression and electrode sustainability through structural confinement and dynamic recyclability.}, archive = {J_ANGEW}, author = {Leiqian Zhang and Ke Luo and Jiaming Gong and Yazhou Zhou and Hele Guo and Yi Yu and Guanjie He and Jean-François Gohy and Ivan P. Parkin and Johan Hofkens and Qing He and Tianxi Liu and Klaus Müllen and Feili Lai}, doi = {10.1002/anie.202506822}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506822}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking durable and sustainable Zinc–Iodine batteries via molecularly engineered polyiodide reservoirs}, volume = {64}, year = {2025}, }
• (2025). Copper-photoredox-catalyzed C(sp3)–C(sp3) reductive cross-coupling of alkyl bromides with BCP-thianthrenium reagents. ANGEW, 64(30), e202506785. (www)

  @article{ , abstract = {Herein, we report a reductive cross-coupling reaction of bicyclo[1.1.1]pentyl (BCP)-thianthrenium reagents and alkyl bromides. The reaction is catalyzed by a copper/photoredox catalyst system. The approach is the first example of a cross-coupling between BCP-based reagents with alkyl electrophiles.}, archive = {J_ANGEW}, author = {Saikat Pandit and Tobias Ritter}, doi = {10.1002/anie.202506785}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506785}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-photoredox-catalyzed C(sp3)–C(sp3) reductive cross-coupling of alkyl bromides with BCP-thianthrenium reagents}, volume = {64}, year = {2025}, }
• (2025). Enantioselective total synthesis of (–)-psiguadial a. ANGEW, 64(30), e202506537. (www)

  @article{ , abstract = {The first enantioselective total synthesis of the antiproliferative natural product (–)-psiguadial A is reported. This approach features the enantioselective synthesis of a complex tricyclic terpenoid precursor, the union of that precursor with a polyketide component by an enolate- ortho -quinone methide coupling reaction to form a highly congested carbon─carbon bond, and an acid-mediated intramolecular hydration ring-closure leveraging a fully substituted alkene to generate the unique oxepane core structure of the natural product.}, archive = {J_ANGEW}, author = {Liam P. O'Grady and Marcel Achtenhagen and Michael F. Wisthoff and Robert S. Lewis and Katarina Pfeifer and Weifeng Zheng and Maxwell I. Martin and Glenn P. A. Yap and William J. Chain}, doi = {10.1002/anie.202506537}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506537}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective total synthesis of (–)-psiguadial a}, volume = {64}, year = {2025}, }
• (2025). Highly enantioselective organocatalysis with bidentate halogen bond donors. ANGEW, 64(30), e202506476. (www)

  @article{ , abstract = {As the employment of “non-classical” non-covalent interactions like halogen bonding (XB) in asymmetric catalysis is still at a very early stage, there are significant challenges to overcome. In some reported cases, the relevance of halogen bonding to the catalytic action is unclear, while in others, catalyst activity is limited. Herein, we present the second generation of a bidentate iodine(I)-based halogen bond donor as a modifiable and highly active chiral halogen bonding catalyst. With these modified derivatives, high stereocontrol of up to 98% ee could be achieved in a model Mukaiyama aldol reaction for a range of different substrates. Importantly, the crucial role of halogen bonding in this catalytic process was demonstrated by the low performance of the non-iodinated variants and by DFT calculations. The latter also indicate that the stereoinduction is based on the imposed orientation of the substrates towards each other.}, archive = {J_ANGEW}, author = {Julian Wolf and Meghana Poliyodath Mohanan and Raphaël Robidas and Revannath L. Sutar and Elric Engelage and Claude Y. Legault and Stefan M. Huber}, doi = {10.1002/anie.202506476}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506476}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly enantioselective organocatalysis with bidentate halogen bond donors}, volume = {64}, year = {2025}, }
• (2025). Plasmonic DNA-barcoded virion nano-oscillators for multiplexed quantification of small-molecule binding kinetics to membrane proteins. ANGEW, 64(30), e202506464. (www)

  @article{ , abstract = {A high-density nano-oscillator platform using self-assembled DNA-barcoded virion sensors is developed to address the critical need for high-throughput label-free measurement of small-molecule binding to membrane proteins. By integrating virion display technology with charge-sensitive plasmonic detection, our platform enables robust, label-free quantification of small-molecule binding kinetics to membrane proteins. Gold nanoparticle-virion conjugates are self-assembled onto a plasmonic sensor chip via a flexible molecular linker to form high-density nano-oscillators. Driven by an alternating electric field, the oscillation amplitudes of the nano-oscillators are precisely measured via widefield plasmonic imaging. This charge-sensitive mechanism can sensitively detect the binding of small-molecule ligands to the membrane proteins displayed on the virions at single-nanosensor resolution, overcoming the sensitivity limit of conventional mass-sensitive techniques. More importantly, the platform employs novel affinity-discriminated DNA barcodes for multistate decoding with exponential multiplexing capacity, enabling high-throughput screening of a library of membrane proteins. For a proof-of-concept demonstration, binding kinetics of five pairs of G-protein-coupled receptors and their corresponding small molecule ligands are measured on a single sensor chip, with all individual nano-oscillators identified by just two affinity-discriminated, quadra-state DNA decoders. This technology advances membrane protein research and drug screening capabilities, offering a practical solution for biomolecular interaction studies and biosensing applications.}, archive = {J_ANGEW}, author = {Shuo-Hui Cao and Zijian Wan and Eric Johansen and Guangzhong Ma and Prashant Desai and Heng Zhu and Shaopeng Wang}, doi = {10.1002/anie.202506464}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506464}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plasmonic DNA-barcoded virion nano-oscillators for multiplexed quantification of small-molecule binding kinetics to membrane proteins}, volume = {64}, year = {2025}, }
• (2025). Phenylene cage synthesized by metal-mediated assembly of phenylene macrocycle and its piezofluorochromic behavior. ANGEW, 64(30), e202506376. (www)

  @article{ , abstract = {A phenylene macrocycle containing two meta-phenylene units positioned opposite each other was used as a building block to construct phenylene cages via platinum-mediated C─C coupling. A phenylene cage (PC[10]3), consisting of three phenylene macrocycle units, was successfully synthesized and thoroughly characterized using nuclear magnetic resonance (NMR) spectroscopy and single-crystal X-ray diffraction. PC[10]3 exhibited significant backbone strain and displayed bright blue emission with a quantum yield of 96%. Additionally, PC[10]3 exhibited a broader and more pronounced piezofluorochromic response compared to its macrocyclic unit, undergoing a distinct photoluminescence shift from blue to yellow–green under pressure. This work opens new avenues for designing and synthesizing hydrocarbon nanocages.}, archive = {J_ANGEW}, author = {Qing-Song Deng and Xuan-Wen Chen and Xi-Han Yu and Jiang-Feng Xing and Bing-Hui Zheng and Guanjun Xiao and Bo Zou and Yuan-Zhi Tan}, doi = {10.1002/anie.202506376}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506376}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phenylene cage synthesized by metal-mediated assembly of phenylene macrocycle and its piezofluorochromic behavior}, volume = {64}, year = {2025}, }
• (2025). Fluorination-assisted interfacial dipole for CsPbI3 perovskite solar cells with over 22% efficiency. ANGEW, 64(30), e202506282. (www)

  @article{ , abstract = {Inorganic CsPbI 3 perovskite attracts widespread attention in photovoltaic applications due to its superior thermal stability and optoelectronic properties. However, CsPbI 3 perovskite solar cells (PSCs) still suffer from severe energy losses due to interface nonradiative recombination and undesirable charge carrier transfer, predominantly limiting their photovoltaic performance. Herein, an interfacial dipole engineering is introduced for CsPbI 3 PSCs, in which azetidinium chloride (Az) and its fluorinated derivative 3,3-difluoroazetidinium chloride (DFAz) are employed to manipulate the interface properties of PSCs and thus diminish energy losses. Systematically theoretical calculations and experimental studies reveal that the fluorination-assisted ammonium molecule could form a stronger interaction with perovskites and thereby arrange the dipole alignment on the superficial layer of perovskites, which could simultaneously ameliorate the passivation effect and energy level alignment of the perovskite and hole transport layers, thereby suppressing interface recombination. Meanwhile, the coordinated bonding between the ammonium and hole transport layer facilitates charge transfer at the heterojunction interface by offering additional carrier transport channels. Consequently, the CsPbI 3 PSCs deliver a high efficiency of up to 22.05%. This work provides important design principles of interface engineering for high-performance solar cells to minimize energy losses.}, archive = {J_ANGEW}, author = {Junming Qiu and Xinyi Mei and Mingxu Zhang and Guoliang Wang and Lixin Pan and Shenwen Zou and Jianmei Huang and Xiaoliang Zhang}, doi = {10.1002/anie.202506282}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506282}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorination-assisted interfacial dipole for CsPbI3 perovskite solar cells with over 22% efficiency}, volume = {64}, year = {2025}, }
• (2025). Dynamic hydrogen bonding tuned enantioselectivity control in cobaloxime-chiral amine cooperative catalysis. ANGEW, 64(30), e202506268. (www)

  @article{ , abstract = {Cobaloxime is a versatile 3 d -metal catalyst for dehydrogenative radical coupling reactions. Prior mechanistic studies of cobaloxime catalysis have revealed that cobaloxime(II)-catalyzed hydrogen atom transfer (HAT) process can control the site-selectivity and chemoselectivity of radical transformation. However, the relevance of HAT to the enantioselectivity is seldom reported. Herein, our density functional theory studies of the cobaloxime-chiral amine co-catalyzed enantioselective coupling of the enamine radical cation with alkene proved that it is the HAT step that determines the enantioselectivity, instead of the previously proposed radical addition. Because the metal–alkene-coupled (MAC) radical addition is a reversible process while the followed by HAT is the rate-determining step. Moreover, computational studies suggest that the dynamically changing hydrogen bonding between the radical cation and cobaloxime plays a significant role in harnessing the reactivity and tuning the enantiocontrol. The intra- and inter-molecular hydrogen bonding between the iminium and the cobaloxime fragments contributes to the lower energy barrier of MAC radical addition. Structural analysis and quantitative steric-electronic effect dissection jointly unveiled that the stronger intermolecular hydrogen bonding between the aminium and the cobaloxime fragments is the dominant factor that stabilizes the ( R )-HAT transition state and guarantees high enantioselectivity.}, archive = {J_ANGEW}, author = {Zhao Liu and Long Zhang and Sanzhong Luo and Xiaotian Qi}, doi = {10.1002/anie.202506268}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202506268}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic hydrogen bonding tuned enantioselectivity control in cobaloxime-chiral amine cooperative catalysis}, volume = {64}, year = {2025}, }
• (2025). Lignin dissolution and direct ultrasmall-lignin-nanoparticle formation in acidic and alkaline deep eutectic solvents: A molecular-level insight. ANGEW, 64(30), e202505975. (www)

  @article{ , abstract = {Although deep eutectic solvents (DESs) have demonstrated significant potential in lignin processing, their influence on molecular stacking and conformational evolution during lignin dissolution and nanoparticle formation remains insufficiently understood. Here, we develop a green, straightforward, and single-step approach to produce self-assembled lignin nanoparticles (LNPs). The LNPs obtained using the acidic DES method exhibited a great size reduction, with an average size approximately one-ninth of that produced by conventional solvent-exchange methods. To gain mechanistic insights into the reconstruction, dissolution, and self-assembly of lignin in DESs, we integrate structural characterization with molecular dynamics simulations. Specifically, we simulate the dynamic behavior and configurational states of high-molar-mass lignin models (4,182 g mol −1 ) in aqueous solvent systems. The results reveal the critical role of molecular structure, intra/intermolecular π–π interactions, stacked conformations, solvent-specific effects in determining the size and compactness of LNPs. Notably, the DES stabilizes lateral-shifted configurations, promoting the formation of small and compact LNPs. In contrast, the tetrahydrofuran/H 2 O solvent system favors offset-stacked configurations and hydrophobic interactions, leading to larger, spherical LNPs. Overall, our findings offer new insights into the underlying mechanisms of LNP formation using DESs, demonstrating the possibility of regulating and controlling lignin assemblies through solvent parameters.}, archive = {J_ANGEW}, author = {Xin Yue and Jinxin Lin and Otto Mankinen and Terhi Suopajärvi and Marja Mikola and Atte Mikkelson and Harri Huttunen and Liheng Chen and Juha Ahola and Ville-Veikko Telkki and Shirong Sun and Henrikki Liimatainen}, doi = {10.1002/anie.202505975}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505975}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lignin dissolution and direct ultrasmall-lignin-nanoparticle formation in acidic and alkaline deep eutectic solvents: A molecular-level insight}, volume = {64}, year = {2025}, }
• (2025). Homogenized self-assembled molecules for inverted perovskite solar cells. ANGEW, 64(30), e202505876. (www)

  @article{ , abstract = {Inverted perovskite solar cells (PSCs) have rapidly improved, driven by advancements in self-assembled molecules (SAMs). However, achieving homogeneous SAM coverage on substrates remains challenging, directly impacting device performance and stability. Here, we present (4-(pyren-1-yl)phenyl)phosphonic acid (PhPAPy), a SAM with a rigid aromatic ring structure. Ab initio molecular dynamics (AIMD) simulations reveal that this rigidity limits rotational freedom, promoting a near-vertical molecular orientation on the substrate. Additionally, π–π interactions between the planar pyrene rings enhance molecular packing, forming a homogeneous and dense SAM layer. As a result, the uniform PhPAPy effectively minimizes perovskite–substrate direct contact, enhances the interfacial properties, reduces buried interface defects, and improves both efficiency and stability. With PhPAPy SAM, the assembled inverted PSCs achieve a certified reverse-scanning power conversion efficiency (PCE) of 26.74% and a certified stabilized power output (SPO) efficiency of 26.12% (from National Institute of Metrology in China). These devices retain 95% of their initial efficiency after 2000 h of maximum power point tracking (MPPT) under continuous AM 1.5G illumination at 65 °C and ambient humidity (ISOS-L-2).}, archive = {J_ANGEW}, author = {Yu Feng and Yu Wang and Hao Yang and Saisai Li and Jiefeng Luo and Xue Han and Thamraa Alshahrani and Bo Mai and Di Wang and Zijin Ding and Wenda Sun and Changjiu Sun and Quanlin Chen and Keyu Wei and Yanxing Feng and Lutong Song and Xiyan Li and Xiao-Ye Wang and Wen-Di Li and Qinyou An and Yuanzhi Jiang and Mingjian Yuan}, doi = {10.1002/anie.202505876}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505876}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Homogenized self-assembled molecules for inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Selective electrocatalytic hydrodimerization of acetylene to 1,3-butadiene over neighboring cu dual sites. ANGEW, 64(30), e202505843. (www)

  @article{ , abstract = {Selective electrocatalytic hydrodimerization of acetylene to 1,3-butadiene is a promising alternative to the energy-intensive naphtha steam cracking route, but remains a grand challenge due to competitive acetylene semihydrogenation and oligomerization. Herein, we profoundly investigate the underpinning structure–performance correlations between diverse nuclear number of Cu sites and acetylene hydrodimerization over benchmark Cu-MOFs electrocatalysts. The operando electrochemical Raman and Fourier transform infrared spectroscopies and theoretical simulations together reveal that single Cu site and double Cu sites are favorable for acetylene semihydrogenation and hydrodimerization, respectively. The as-designed neighboring Cu dual sites in trinuclear Cu 3 -MOF enable the adsorption of acetylene, subsequent C–C coupling of *C 2 H 2 and *C 2 H 3 intermediates into 1,3-butadiene as well as the desorption of 1,3-butadiene. As a result, the trinuclear Cu 3 -MOF affords a 1,3-butadiene selectivity of 91% and a high 1,3-butadiene production rate of 64 mmol g −1 h −1 , which is about 2-fold and 20-fold higher than Cu 2 -MOF and Cu 1 -MOF. This work not only provides profound insights into the electrocatalytic mechanism of acetylene hydrodimerization but also guides the rational design of high-activity electrocatalysts.}, archive = {J_ANGEW}, author = {Jun Bu and Xinyue Niu and Jinjin Li and Rui Bai and Menglei Yuan and Jian Zhang}, doi = {10.1002/anie.202505843}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505843}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective electrocatalytic hydrodimerization of acetylene to 1,3-butadiene over neighboring cu dual sites}, volume = {64}, year = {2025}, }
• (2025). Breaking symmetry of active sites in metal-organic frameworks for efficient photocatalytic valorization of polyester plastics. ANGEW, 64(30), e202505786. (www)

  @article{ , abstract = {Chemical upcycling of waste plastics offers a promising way toward achieving a circular economy and alleviating environmental pollution but remains a huge challenge. Inspired by hydrolase enzymes and aiming to overcome their intrinsic limitations, we put forward a design principle for an innovative nanozyme featuring asymmetric metal sites. This nanozyme functions as photocatalyst, enabling sustainable valorization of polyester plastics. As a proof of concept, an asymmetric ligand substitution strategy is developed to construct metal-organic frameworks (MOFs) that are defective MIL-101(Fe) (D-MIL-101) with asymmetric Fe 3-δ /Fe 3+ (0< δ <1) sites. The differential electronic configurations inherent to adjacent Fe 3-δ /Fe 3+ sites endow a high photocatalytic activity for the valorization of polyester plastic. Accordingly, the ester bonds of polyesters can be preferentially cleaved, contributing to the low energy barrier of upcycling plastics. As a result, the D-MIL-101 achieves a high monomer yield with terephthalic acid (TPA) of ∼93.9% and ethylene glycol (EG) of ∼87.1% for photocatalytic valorization of poly (ethylene terephthalate) (PET), beyond the efficiency of natural enzymes and state-of-the-art photocatalysts. In addition, such a D-MIL-101 is demonstrated to be feasible for the valorization of various real-world polyester plastic wastes in a flow photocatalysis system.}, archive = {J_ANGEW}, author = {Jibo Qin and Jianchi Zhou and Jin Ma and Shuang Li and Awu Zhou and Linhua Xie and Yibo Dou and Yuanjian Zhang}, doi = {10.1002/anie.202505786}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking symmetry of active sites in metal-organic frameworks for efficient photocatalytic valorization of polyester plastics}, volume = {64}, year = {2025}, }
• (2025). PCET photodecarboxylation for SN2’-type alkylation of gem-dichlorocyclobutenones. ANGEW, 64(30), e202505782. (www)

  @article{ , abstract = {Metal-catalyzed nucleophilic S N 2’-type alkylation of gem -dichlorocyclobutenones with organometallic reagents remained unsuccessful. Herein, we report an acridine-catalyzed radical S N 2’ alkylation of both β-alkyl and β-aryl substituted gem -dichlorocyclobutenones with free carboxylic acids. In this process, Csp 3 -enriched 4-alkylated 2-chlorocyclobutenones are obtained with commendable functionality tolerance. A PCET photodecarboxylation enables for the first time S N 2’-type alkylation of gem -dichlorocyclobutenones with β-H-containing carboxylic acids, addressing several challenges. This mild and scalable Csp 3 ─Csp 3 bond-forging alkylation applies to the functionalization of natural product-derived gem -dichlorocyclobutenones with carboxylic acid drugs, fatty acids, and steroids. The α-chlorocyclobutenone product is further exploited in divergent organic synthesis via postsynthetic modification.}, archive = {J_ANGEW}, author = {Pinku Prasad Mondal and Subham Das and Sourav Das and Basudev Sahoo}, doi = {10.1002/anie.202505782}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505782}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PCET photodecarboxylation for SN2’-type alkylation of gem-dichlorocyclobutenones}, volume = {64}, year = {2025}, }
• (2025). Isoreticular synthesis of mesoporous metal-organic polyhedra with permanent porosity to gas and water. ANGEW, 64(30), e202505682. (www)

  @article{ , abstract = {Synthesis of mesoporous metal-organic cages or polyhedra (MOCs or MOPs) that retain their porous functionality in the solid-state remains challenging, given their tendency to collapse upon desolvation. Herein, we report the use of the isoreticular expansion approach to synthesize two permanently porous Rh(II)-based octahedral MOPs within the mesoporous regime. Our mesoporous MOPs, featuring internal cavities of up to 12.5 nm 3 , withstand the activation process, enabling their use as solid-state adsorbents for gases and water. In particular, the largest mesoporous MOP, named BCN-17, captures up to 0.47 g water ·g MOP −1 and exhibits an S-shaped water-sorption isotherm with a hysteresis loop, characteristic of mesoporous materials.}, archive = {J_ANGEW}, author = {Alba Cortés-Martínez and Pilar Fernández-Seriñán and Cornelia von Baeckmann and Caterina Caules and Laura Hernández-López and María Susana Gutiérrez Gómez and Yunhui Yang and Roberto Sánchez-Naya and José A. Suárez del Pino and Judith Juanhuix and Inhar Imaz and Arnau Carné-Sánchez and Daniel Maspoch}, doi = {10.1002/anie.202505682}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505682}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isoreticular synthesis of mesoporous metal-organic polyhedra with permanent porosity to gas and water}, volume = {64}, year = {2025}, }
• (2025). Functional dendrimer nanogels for DNA delivery and gene therapy of tumors. ANGEW, 64(30), e202505669. (www)

  @article{ , abstract = {Solving the dilemma between efficacy and cytotoxicity of cationic colloidal vectors is one of the biggest challenges in gene delivery. Cationic dendrimer assemblies with hierarchical structure, smart and biomimetic behaviors have been developed for drug/gene delivery in vivo. Among different dendrimer assemblies, the dendrimer-based nanogels were not intensively studied due to complicated synthesis and unknown properties. Here, for the first time, low-generation dendrimer nanogels with high yield and purity, tunable size, uniform morphology, and good colloidal stability were synthesized using the emulsion-free method, which cannot be obtained by the miniemulsion method. Importantly, the dendrimer nanogels integrate the advantages of low-generation dendrimer and stimuli-responsive polymer, thus achieving dual-active groups, o -hydroxyl amine units, temperature-responsiveness, polyampholyte property, and self-triggered aminolysis. With these unique properties, dendrimer nanogels can “temporarily” acquire high charge density through the covalent crosslinking of low-generation dendrimer for improved DNA compression, promoted cell internalization and lysosomal escape, and efficient DNA delivery, followed by self-triggered aminolysis into small dendrimers to control DNA release, reduce cytotoxicity, and facilitate metabolism in vivo. Compared to high-generation dendrimers, low-generation dendrimer nanogels display higher gene transfection and therapeutic efficacies, and lower side effects simultaneously. This work provides a facile strategy for the preparation of low-generation dendrimer nanogels that break up the contradiction between efficacy and cytotoxicity of cationic colloidal vectors in gene therapy. This innovative approach to construct low-generation dendrimers into smart dendrimer nanogels will have broad applicability in clinical translation.}, archive = {J_ANGEW}, author = {Xin Li and Zhijun Ouyang and Laura Hetjens and Ming Ni and Kuailu Lin and Yong Hu and Xiangyang Shi and Andrij Pich}, doi = {10.1002/anie.202505669}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functional dendrimer nanogels for DNA delivery and gene therapy of tumors}, volume = {64}, year = {2025}, }
• (2025). Air-level oxygen enables 100% selectivity in urea synthesis via photocatalytic C─N coupling of CO and ammonia. ANGEW, 64(30), e202505630. (www)

  @article{ , abstract = {The clean-energy-driven synthesis of urea from carbon- and nitrogen-containing small molecules has garnered significant interest but remained great challenges to achieve with high selectivity. Herein, we present a photocatalytic pathway for the selective urea synthesis through the oxidative coupling between CO and NH 3 . The key factor in this process is the atmospheric O 2 level, which plays a crucial role in controlling both the urea production rate and its selectivity. Using oxygen-deficient TiO 2 under an air-level (20%) O 2 atmosphere, we achieved a urea generation rate of 54.31 mg g cat −1 h −1 with 100% selectivity. This rate is 38.52 times higher than under oxygen-free conditions, while further increasing the O 2 level significantly reduces selectivity. Mechanistic studies reveal that the process begins with the oxidation of NH 3 to •NH 2 through oxidative radicals generated on TiO 2 , especially the oxygen-derived O 2 •– . This •NH 2 radicals then couple with CO to form urea. The concentration of radicals is controlled by the O 2 level, with the optimal concentration under air-level O 2 enabling efficient NH 3 oxidation to •NH 2 while preventing over-oxidation.}, archive = {J_ANGEW}, author = {Xingmiao Huang and Shijie Xie and Bo Sheng and Bowen Xiao and Chuncheng Chen and Hua Sheng and Jincai Zhao}, doi = {10.1002/anie.202505630}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505630}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Air-level oxygen enables 100% selectivity in urea synthesis via photocatalytic C─N coupling of CO and ammonia}, volume = {64}, year = {2025}, }
• (2025). Kelvin probe force microscopy reveals spatially resolved charge-transfer mechanism in CdS/BiOBr S-scheme heterojunction photocatalyst. ANGEW, 64(30), e202505456. (www)

  @article{ , abstract = {S-scheme heterojunctions hold great promise for photocatalysis, yet a comprehensive understanding of their charge-transfer mechanisms remains limited. While time-resolved techniques have provided valuable insights, the spatial resolution of charge transfer at the material surface remains underexplored. Here, we employ Kelvin probe force microscopy (KPFM) to investigate the charge-transfer dynamics in S-scheme heterojunctions, revealing spatially resolved details. Our findings show that upon illumination, the Fermi level ( E f ) of n-type semiconductors increases, but a built-in electric field (IEF) persists within the heterojunction. Electrons accumulate on the surface of the reduction semiconductor (RS), resulting in a surface photovoltage (SPV) lower than that of the individual semiconductor, while holes accumulate on the oxidation semiconductor (OS) surface, producing an SPV higher than that of the bare material. The S-scheme heterojunction leads to a remarkable increase in charge separation, with 11 additional photogenerated electrons and 3722 additional holes compared to the bare CdS and BiOBr. These results offer critical insights into the spatially resolved charge-transfer mechanisms of S-scheme heterojunctions.}, archive = {J_ANGEW}, author = {Zheng Meng and Jianjun Zhang and Haoyu Long and Hermenegildo García and Liuyang Zhang and Bicheng Zhu and Jiaguo Yu}, doi = {10.1002/anie.202505456}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Kelvin probe force microscopy reveals spatially resolved charge-transfer mechanism in CdS/BiOBr S-scheme heterojunction photocatalyst}, volume = {64}, year = {2025}, }
• (2025). Quaternary phosphonium salts enable palladium-catalyzed annulative C─H activation of aminophosphines with alkynes. ANGEW, 64(30), e202505454. (www)

  @article{ , abstract = {Quaternary phosphonium salts, despite their extensive historical study, have remained unexplored as key additives in transition metal catalysis until our current investigation. Here, we present a groundbreaking palladium-catalyzed system for P(III)-directed C─H activation of aminophosphines, followed by annulation with alkynes. By utilizing P-stereogenic aminophosphines, we have achieved the stereospecific synthesis of chiral phosphacycles. This innovative process, facilitated by deprotonative isomerization, efficiently yields a wide range of P-heterocycles. The pivotal breakthrough of our methodology lies in the identification of phosphonium salts as effective additives, which undertake multiple functions: they not only reduce the energy barrier of pivotal steps but also regenerate the palladium catalyst while safeguarding the P(III) directing group from oxidation. Through systematic experimental investigations, particularly by comparing transition states with and without quaternary phosphonium salts, we have elucidated the unique reaction pathway, thereby explaining the critical role of the salts.}, archive = {J_ANGEW}, author = {Lin Lin and Tianbao Wu and Minyan Wang and Ronghui Huang and Xiuxiu Yang and Yue Zhao and Zhuangzhi Shi}, doi = {10.1002/anie.202505454}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505454}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quaternary phosphonium salts enable palladium-catalyzed annulative C─H activation of aminophosphines with alkynes}, volume = {64}, year = {2025}, }
• (2025). Stabilizing the quinoidal form of polycyclic aromatic hydrocarbons by O─B←N units to give a > 1000 nm redshift in the absorption wavelength. ANGEW, 64(30), e202505353. (www)

  @article{ , abstract = {Polycyclic aromatic hydrocarbons (PAHs) have distinct chemical structures and excellent optoelectronic properties. Although PAHs with ultra-large π-conjugated skeletons have been successfully synthesized, ultrasmall bandgap ( E g < 1.2 eV) or short-wavelength infrared (SWIR) light absorption ( λ > 1000 nm) is seldom reported for PAHs. In this work, we design and synthesize a PAH by incorporating four O─B←N units into naphthalene diimide (NDI) as the core. The incorporation of four O─B←N units changes the NDI core from an aromatic form to a quinoidal form, leading to significantly enhanced π-electron delocalization. As a result, the optical bandgap of the molecule decreases from 3.10 to 0.88 eV, and the onset absorption wavelength is redshifted from 400 to 1410 nm. The resulting molecule exhibits strong light absorption in the infrared region and high transparency in the visible region. It can be used to develop colorless infrared anti-counterfeiting technology. This work provides a novel molecular design strategy to tune optoelectronic properties of PAHs.}, archive = {J_ANGEW}, author = {Canyun Mao and Xingxin Shao and Jun Liu and Lixiang Wang}, doi = {10.1002/anie.202505353}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilizing the quinoidal form of polycyclic aromatic hydrocarbons by O─B←N units to give a > 1000 nm redshift in the absorption wavelength}, volume = {64}, year = {2025}, }
• (2025). Regulating reactive oxygen species via orbital rehybridization between intermediate and active site for selective methane photooxidation to methanol. ANGEW, 64(30), e202505267. (www)

  @article{ , abstract = {Photocatalytic oxidation of methane (POM) to CH 3 OH provides a promising pathway for sustainable chemical industry, while uncontrollable generation of reactive oxygen species (ROS) would proceed at the expense of compromised catalytic activity or selectivity of POM. Herein, we precisely control the type of as-formed ROS by introducing Au single atoms (SAs) on CuO x /ZnO (Au 1 -CuO x /ZnO), to simultaneously achieve high selectivity and productivity of CH 3 OH in POM. In situ characterizations and theoretical calculations revealed that the introduced Au SAs significantly altered the electronic structure of Cu atoms, leading to an energy level rearrangement of Cu 3d orbital and the upshift of d-band center, which increased the energy levels of bonding and antibonding states of Au 1 -CuO x /ZnO-*OOH. Thus, the hybridization between Cu active sites and the key intermediate *OOH was significantly enhanced, especially for the orbital hybridizations of d z 2 -p z and d xz /d yz -p x . This facilitated the dissociation of O─O to form *OH intermediate rather than the direct desorption of *OOH, thereby ultimately determining the ROS type in aerobic POM. Additionally, the asymmetric electronic structure of Au 1 -CuO x /ZnO could also lower the first C–H dissociation energy by structural polarization of CH 4 molecules. As a result, Au 1 -CuO x /ZnO exhibited an excellent CH 3 OH productivity of 16856 µmol·g cat. −1 with 100% selectivity during POM at mild conditions.}, archive = {J_ANGEW}, author = {Fangyuan Si and Junxian Bai and Yan Li and Ruimin Lan and Shijing Cheng and Tingting Hou and Yingwei Li}, doi = {10.1002/anie.202505267}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505267}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating reactive oxygen species via orbital rehybridization between intermediate and active site for selective methane photooxidation to methanol}, volume = {64}, year = {2025}, }
• (2025). Tailoring oxygen vacancies with atomically dispersed cu sites for stable and efficient photothermal CO2 conversion. ANGEW, 64(30), e202505244. (www)

  @article{ , abstract = {Photothermal catalysis under mild conditions represents a promising and sustainable approach for CO 2 conversion into high-value chemicals, thereby enabling efficient carbon recycling. However, precise manipulation of active sites and their coordination environments at the atomic level to enhance catalyst performance still remains a challenge. Here, we present a single-atom doping strategy for oxygen vacancy engineering to facilitate efficient CO 2 conversion. Specifically, an In 2 O 3 -based catalyst with abundant oxygen vacancies induced by homogeneously dispersed Cu single atoms is constructed, exhibiting a competent CO 2 reduction performance in photothermal reverse water-gas shift reaction. The optimal Cu-In 2 O 3 catalyst achieves a CO yield rate of 46.17 mol g Cu −1 h −1 with near-unity selectivity (>99%) and demonstrates stability over 450 h under 3 W cm −2 full-spectrum light illumination. Comprehensive spectroscopic characterization and computational simulations elucidate that the Cu single atoms synergistically interact with oxygen vacancies to promote H 2 dissociation and CO 2 activation under photoexcitation. This work provides insights into the design of photothermal catalysts, emphasizing the transformative potential of atomic-site engineering for efficient CO 2 conversion and sustainable energy technologies.}, archive = {J_ANGEW}, author = {Xueying Wan and Yilin Zhao and Yifan Li and Jun Ma and Yadi Gu and Caiyi Liu and Yan Luo and Guang Yang and Yi Cui and Dong Liu and Yujie Xiong}, doi = {10.1002/anie.202505244}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505244}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring oxygen vacancies with atomically dispersed cu sites for stable and efficient photothermal CO2 conversion}, volume = {64}, year = {2025}, }
• (2025). π-bridge-linked ionic covalent organic framework with fast reaction kinetics for high-rate-capacity lithium-ion batteries. ANGEW, 64(30), e202505207. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have emerged as promising cathode materials for high-performance lithium-ion batteries (LIBs) due to their well-defined topologies and tunable pore architectures. However, their practical application is often limited by intrinsically sluggish charge transfer and inferior reaction kinetics. To address these challenges, we develop an ionic quinoline-linked COF (iQCOF) cathode via a one-pot Povarov reaction with triazole ionic liquid. The iQCOF architecture achieves a synergistic enhancement by integrating π-bridge-induced charge delocalization to facilitate charge transport, the specific adsorption effect to gain fast ionic atmosphere dissociation rate, and polar triazine units to enable uniform ion flux for stable interfaces. As a result, iQCOF delivers a high specific capacity of 407 mAh g −1 with 701 Wh kg −1 , and exceptional rate capability (121 mAh g −1 at 10 A g −1 ) with 0.0027% per cycle over 10 000 cycles, further highlighting its potential as a high-performance organic cathode. This work provides a convenient strategy for advanced COF-based cathodes with fast reaction kinetics to achieve high-rate performance, paving the way for next-generation energy storage technologies.}, archive = {J_ANGEW}, author = {Ju Duan and Feng Chen and Huajie Yu and Shenbo Zhu and Likuan Teng and Kexiang Wang and Tiejun Chen and Wei Lyu and Huawei Hu and Yaozu Liao}, doi = {10.1002/anie.202505207}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505207}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π-bridge-linked ionic covalent organic framework with fast reaction kinetics for high-rate-capacity lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Deconstructive functionalization of cyclic ketones via electrochemical interrupted Dowd–Beckwith reaction. ANGEW, 64(30), e202505155. (www)

  @article{ , abstract = {Deconstructive functionalization of cyclic molecules has recently emerged as a prominent strategy to access unique architectures that are challenging to prepare through traditional methods. While significant progress has been made in the deconstructive functionalization of cyclic alcohols and amines, the strategies for deconstructing cyclic ketones remain largely unexplored. The Dowd–Beckwith reaction, a ring-expansion of cyclic ketones, is a powerful method for synthesizing medium- and large-ring compounds. Herein, we developed the first interrupted Dowd–Beckwith (IDB) reaction for highly regioselective deconstructive functionalization of cyclic ketones using electricity as the sole oxidant. This protocol is widely applicable for the deconstruction of small, medium-sized, and macrocyclic ketones bearing a diverse range of functional groups. Remarkably, various naturally occurring complex cyclic ketones were successfully deconstructed into acyclic molecules, which are difficult to access by known strategies. The method was applied to the asymmetric synthesis of planococcol, citrilol acetate, maconelliol, and its derivatives. Furthermore, the functional groups incorporated during the transformation provided versatile handles for subsequent synthetic modifications. Mechanistic experiments and computational studies support an oxidative radical-polar crossover followed by deconstructive functionalization.}, archive = {J_ANGEW}, author = {Tushar Singha and Jyothirlatha V. N. Kasu and Durga Prasad Hari}, doi = {10.1002/anie.202505155}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505155}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deconstructive functionalization of cyclic ketones via electrochemical interrupted Dowd–Beckwith reaction}, volume = {64}, year = {2025}, }
• (2025). Molecularly woven artificial solid electrolyte interphase. ANGEW, 64(30), e202505056. (www)

  @article{ , abstract = {Lithium-metal batteries (LMBs) are the most promising candidates for next-generation high-energy-density storage systems, but they suffer from destructive dendrite growth. Here, we integrate cutting-edge molecular weaving technology into the fabrication of artificial solid electrolyte interphases (ASEI) to realize dendrite-free and long-lasting LMBs. Specifically, weaving polymer chains into a 2D plane endows polymer network crystals with high strength and elasticity and creates angstrom-level meshes for Li-ion transport and uniform deposition. As a result, related Li plating experiments remained stable at an unprecedentedly high current density of 5 mA cm −2 . Furthermore, full cells with “woven” ASEI exhibited superior long-term cycling performance compared to existing 2D materials, achieving a capacity retention of 98% over 270 cycles under stringent testing conditions.}, archive = {J_ANGEW}, author = {Tianyu Shan and Zhijin Ju and Ding Xiao and Ke Yue and Zhenxing Cui and Yifei Zhang and Xiaodong Chi and Xiulin Fan and Guangfeng Li and Xinyong Tao and Feihe Huang}, doi = {10.1002/anie.202505056}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505056}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecularly woven artificial solid electrolyte interphase}, volume = {64}, year = {2025}, }
• (2025). Delicate control over electron distribution and water dissociation kinetics in strongly coupled Ru@NMoC hybrid catalyst realizes efficient seawater electrolysis. ANGEW, 64(30), e202505031. (www)

  @article{ , abstract = {Delicate control over electron distribution in hybrid catalysts is crucial for improving hydrogen evolution catalysis, which remains an aspirational target in advancing efficient hydrogen production. Herein, we optimize the local electronic structures and balance the reaction steps by incorporating Ru clusters into nitrogen-doped molybdenum carbide (denoted as Ru@NMoC), addressing performance limitations in alkaline seawater. The Ru@NMoC catalyst demonstrates ultralow overpotentials of 8, 17, and 20 mV at 10 mA cm⁻ 2 in 1 M KOH, 1 M KOH + 0.5 M NaCl, and 1 M KOH seawater, respectively, significantly outperforming conventional HER catalysts. Operando spectroscopic techniques reveal strong ability for interface water dissociation and stable local charge structure in Ru@NMoC. Theoretical simulations demonstrate that N-doping of Ru clusters self-optimizes their electronic states and lowering the energy barrier for water dissociation. Self-powered H 2 production system can be achieved using Zn–H₂O batteries to drive anion exchange membrane water electrolysis cell, demonstrating its practicability.}, archive = {J_ANGEW}, author = {Jintao Zhao and Jie Wang and Jixin Yao and Liang Li and Dongmeng Chen and Guang Li and Genqiang Zhang}, doi = {10.1002/anie.202505031}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202505031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Delicate control over electron distribution and water dissociation kinetics in strongly coupled Ru@NMoC hybrid catalyst realizes efficient seawater electrolysis}, volume = {64}, year = {2025}, }
• (2025). Concurrent production of glycolic acid via anode valorization of plastic paired with cathode upcycling of biomass derivative. ANGEW, 64(30), e202504993. (www)

  @article{ , abstract = {Electrochemical upcycling of polyethylene-terephthalate-derived (PET-derived) ethylene glycol (EG) into valuable chemicals, such as glycolic acid (GA), provides a sustainable route for reclaiming the carbon resource in plastic wastes. However, valorization of EG to GA is realized solely via anodic oxidation, which is typically accompanied by the generation of low-value hydrogen at the cathode. Here, we develop a GA production system that combines anodic and cathodic GA production via oxidation of PET-derived EG paired with reduction of biomass-derived oxalic acid, which is made possible by the discovery of a robust PdBi alloy anode and earth-abundant TiO 2 cathode. Building on the theoretical understanding and experimental demonstration of anti-CO poisoning on the PdBi anode and temperature-dependent GA electrosynthesis on the TiO 2 cathode, our integrated electrochemical system achieves a total Faradaic efficiency of 182% for GA production. This proof-of-concept electrochemical coupling strategy paves the way for high-efficiency utilization of surplus plastic-/biomass-derived feedstocks via renewable-electricity-driven electrocatalysis.}, archive = {J_ANGEW}, author = {Sailei Kang and Wenfang Yuan and Xuyun Guo and Yu Zhang and Jian Shang and Peinuo Yang and Yingxin Ma and Valeria Nicolosi and Lejuan Cai and Bocheng Qiu}, doi = {10.1002/anie.202504993}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504993}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concurrent production of glycolic acid via anode valorization of plastic paired with cathode upcycling of biomass derivative}, volume = {64}, year = {2025}, }
• (2025). Enzyme induced solid-like condensates formation of engineered peptide in living cells for prostate cancer inhibition. ANGEW, 64(30), e202504958. (www)

  @article{ , abstract = {This work describes the rational design and synthesis of hepsin-recognized amphiphilic-branched peptides ( DMN-SIPL ) that can form solid condensates through liquid–liquid phase separation (LLPS) upon enzymatic reaction. The peptide forms solid-like condensates both in vitro and in living cells, triggered by type-II membrane-associated serine peptidase, hepsin, whose overexpression determines prostate cancer progression. Specifically, integrating self-assembly, hepsin hydrolysis, and hepsin-binding domain generates a branched substrate that acts as a precursor for enzyme-induced LLPS. Upon binding hepsin on the cell membrane, DMN-SIPL forms condensates initiated by hepsin-induced self-assembly. The prostate cancer cells then uptake these condensates via lipid raft-mediated endocytosis. The entrapped hepsin in the condensates further hydrolyzes the DMN-SIPL to stabilize the intracellular condensates. Structure–activity relationship reveals the importance of enzyme-binding motif, enzyme-recognized motif, and the self-assembly motif. Mechanistic studies indicate that the resulting solid-like condensates modulate cancer cell metabolism by inhibiting hepsin upstream protein activation and downstream signal transduction, ultimately inducing cancer cell growth inhibition selectively. As a first example, this work investigates enzymatic LLPS condensate formation in living cells, paving the way to generate functional synthetic biomolecular condensates through LLPS for biomedical applications.}, archive = {J_ANGEW}, author = {Ying Li and Tengyan Xu and Yaoting Li and Huaimin Wang}, doi = {10.1002/anie.202504958}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504958}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzyme induced solid-like condensates formation of engineered peptide in living cells for prostate cancer inhibition}, volume = {64}, year = {2025}, }
• (2025). Interface engineering of branched PdCoPx nanostructures for high-performance Lithium–Oxygen batteries. ANGEW, 64(30), e202504924. (www)

  @article{ , abstract = {Developing advanced cathode materials plays a positive role in lowering the charge/discharge overpotentials and improving the cycling performance of lithium–oxygen batteries (LOBs). Here we report a direct synthesis strategy to prepare high-dimensional branched PdCoP x series nanostructures, in which the Pd atoms are well dispersed within cobalt phosphide, leading to rich Pd─Co─P interfaces and evoking a prominent ligand effect between the elements. The Pd 1 Co 2 P x exhibits an excellent and stable activity for oxygen reduction reaction (ORR) in alkaline media, with a mass activity of 1.46 A mg Pd −1 , far exceeding that of commercial Pd/C (0.12 A mg Pd −1 ) and Pt/C (0.17 A mg Pt −1 ). Using Pd 1 Co 2 P x as the cathode, the resulting LOB shows an ultralow discharge/charge overpotential of 0.40 V and could run stably for over 240 cycles, which is a significant improvement compared with the counterparts using CoP x and Pd/C cathodes. Experimental and density functional theory (DFT) calculation results indicate that the dispersed Pd atoms could significantly enhance the ORR kinetics, and the Pd─Co─P interfaces could direct the two-dimensional growth of Li 2 O 2 , thereby facilitating the formation of more easily decomposable film-like Li 2 O 2 products. This feature successfully elevates both the charge and discharge performances, as well as the stability of the LOB.}, archive = {J_ANGEW}, author = {Zhiyuan Xu and Yu Zhang and Hong Yu and Zewen Zhuang and Xingdong Wang and Jiaqi Zhang and Xin Tan and Chang Chen and Xin Chen and Qiuhua Yuan and Chen Chen}, doi = {10.1002/anie.202504924}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interface engineering of branched PdCoPx nanostructures for high-performance Lithium–Oxygen batteries}, volume = {64}, year = {2025}, }
• (2025). Molecular-level interface engineering and additive-induced crystallinity tuning for high-performance thermally conductive polymer composites. ANGEW, 64(30), e202504825. (www)

  @article{ , abstract = {To boost up the properties of thermally conductive polymer composites, it is essential to conduct comprehensive research focused on interface engineering between the polymer matrix and fillers. Hexagonal boron nitride (BN) or expanded graphite (EG) are commonly utilized as nanofillers to improve the thermal conductivity of polymer composites. However, the interfacial interactions between the polymer matrix and nanofillers are generally weak, making effective thermal conductivity challenging. To address this issue, we have designed and synthesized an electron-rich and aromatic tetrathiafulvalene-based reactive mesogen (TRM), which not only possesses high thermal conductivity but also exhibits excellent interfacial affinity with BN and EG at the molecular level. Systematic experiments, including photophysical, thermodynamic, structural, and computational analyses, reveal that the thermal conductivity of TRM-based polymer composites is substantially enhanced due to effective interfacial interactions between TRM and fillers. The TRM composites experimentally show excellent thermal conductivity based on enhanced interfacial phonon transfer, and these results are supported by theoretical interpretations. These findings underscore the critical importance of interface engineering between the polymer matrix and fillers at the molecular level in maximizing the material properties of polymer composites.}, archive = {J_ANGEW}, author = {Minwoo Rim and Huan Huu Pham and Hyerim Lee and Jaeseok Hyeong and Youngjae Wi and Jahyeon Koo and Duy Thanh Tran and Seok-In Na and Dong-Gue Kang and Kwang-Un Jeong}, doi = {10.1002/anie.202504825}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504825}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular-level interface engineering and additive-induced crystallinity tuning for high-performance thermally conductive polymer composites}, volume = {64}, year = {2025}, }
• (2025). Liquid coordination polymers with anhydrous proton conductivity. ANGEW, 64(30), e202504618. (www)

  @article{ , abstract = {Liquid states in coordination polymers (CPs) and metal-organic frameworks (MOFs) are typically considered transient intermediates in the crystal-to-glass transformations of organic–inorganic hybrid materials. However, their potential as functional materials has remained largely unexplored. Inspired by the unique properties of ionic liquids, organic liquids, and liquid metals, we explore liquid CPs as a platform for novel functionalities distinct from those of their crystalline and glass counterparts. Here, we present a strategy to achieve functional liquid CPs near ambient conditions by introducing H 3 PO 4 as a network modifier, shifting compositions away from stoichiometric ratios. This process disrupts extended coordination networks during melting, producing a stable liquid state. By tuning the ratio of network modifiers, we achieve control over liquid properties, including anhydrous proton conductivity up to 27 mS cm −1 at 353 K and viscosities ranging from 18.8 to 10 5.9 Pa·s at 303 K. These findings demonstrate the transformative potential of liquid CPs, introducing them as a new platform for designing liquid conductors.}, archive = {J_ANGEW}, author = {Nattapol Ma and Soracha Kosasang and Satoshi Horike and Hiroki Yamada}, doi = {10.1002/anie.202504618}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Liquid coordination polymers with anhydrous proton conductivity}, volume = {64}, year = {2025}, }
• (2025). Host–Guest antimicrobial based on conjugated oligoelectrolyte and cyclodextrin. ANGEW, 64(30), e202504581. (www)

  @article{ , abstract = {The escalating global threat of antimicrobial resistance necessitates the development of new antimicrobial agents. In this study, we prepared a resveratrol-derived antimicrobial conjugated oligoelectrolyte (COE) named DY6 to enhance drug-like properties. While DY6 ’s increased hydrophobicity augmented its antibacterial efficacy, it also induced significant cytotoxicity, highlighting the long-existing dilemma of amphiphilic antimicrobials. To mitigate this issue, we employed a supramolecular strategy by complexing DY6 with sodium sulfobutyl ether β-cyclodextrin ( SβCD ), forming the host–guest inclusion complex DY6@SβCD . This complex elevated the half-maximal inhibitory concentration (IC 50 ) against L929 cells from 9.4 to over 128 µg mL −1 while maintaining a minimum inhibitory concentration (MIC) of 2 µg mL −1 against methicillin-resistant Staphylococcus aureus (MRSA). NMR and UV–vis spectroscopic analyses confirmed that DY6 ’s aromatic backbone is encapsulated within the hydrophobic cavity of SβCD . Isothermal titration calorimetry revealed that size compatibility and electrostatic interactions are essential for stable complex formation and enhanced biocompatibility. Importantly, DY6@SβCD exhibited no resistance development over 14-day serial passages against S. aureus , significantly outperforming norfloxacin. In biofilm-based MRSA-infected wound and corneal models, DY6@SβCD more effectively reduced bacterial load and inflammation compared to the last-resort antibiotic vancomycin. These findings demonstrate the potential utility of supramolecular host–guest approach based on COEs to overcome the drug-resistant challenges.}, archive = {J_ANGEW}, author = {Pengke Liu and Yuhui Chen and Donghao Yao and Jishan Jia and Yingying Meng and Peirong Zhou and Xianan Gao and Yixin Xie and Liang Yao and Shufen Li and Lei Wang and Guillermo C. Bazan and Shaoyong Xu and Cheng Zhou}, doi = {10.1002/anie.202504581}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504581}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Host–Guest antimicrobial based on conjugated oligoelectrolyte and cyclodextrin}, volume = {64}, year = {2025}, }
• (2025). Proton driving mechanism revealed in sulfur-doped single-atom FeN2O2 carbon dots for superior peroxidase activity. ANGEW, 64(30), e202504575. (www)

  @article{ , abstract = {Heteroatom-doped single-atom nanozymes (SAEs) hold great promise as enzyme mimics, yet their catalytic mechanisms remain unclear. This study reveals that the proton driving mechanism induced by sulfur doping in single-atom FeN 2 O 2 carbon dots (S-FeCDs) significantly enhances peroxidase (POD)-like activity. Synthesized via low-temperature carbonization, S-FeCDs exhibit FeN 2 O 2 coordination with sulfur in the second shell, as confirmed by XAFS and AC-STEM. The POD-specific activity of S-FeCDs reached 295 U mg −1 , which is 11.2-fold higher than that of sulfur-free FeCDs, with natural enzyme-like kinetics. In situ experiments, kinetic and mechanistic studies revealed that sulfur doping promotes H 2 O dissociation, enhances H + adsorption, reduces the Δ G for H 2 O 2 -to-·OH conversion. DFT revealed a lowered energy barrier for the rate-determining step (2*OH → *O + *H 2 O) from 2.50 to 1.62 eV. In vivo, S-FeCDs demonstrated broad pH efficacy in MRSA-infected wound models, achieving near-complete healing within 7 days. The proton driving mechanism was further validated through nitro compound reduction, demonstrating accelerated N─H bond activation. This work highlights the critical role of sulfur-induced proton dynamics in enhancing SAEs performance, providing a rational strategy for designing multifunctional nanozymes in biomedical and catalytic applications.}, archive = {J_ANGEW}, author = {Jia Yang and Maolin Wang and Siyu Gao and Meng Zhou and Xiaogang Du and Li Zhang and Ying Wang and Xianxiang Dai and Yuanyuan Jiang and Yunkun Li and Yunsong Zhang and Li Lin}, doi = {10.1002/anie.202504575}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504575}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proton driving mechanism revealed in sulfur-doped single-atom FeN2O2 carbon dots for superior peroxidase activity}, volume = {64}, year = {2025}, }
• (2025). Au6Cu2 clusters with high electron affinity and oxygen-mimetic properties for hypoxic tumor radiosensitization. ANGEW, 64(30), e202504524. (www)

  @article{ , abstract = {Hypoxia-induced radioresistance primarily contributes to the failure of radiotherapy because it hinders the effective fixation of DNA damage. Despite the considerable antitumor activity of chemical molecules such as electron-affinic nitroimidazoles affirmed by clinical studies, their dose-dependent side effects and low radiotherapy efficacy have become major drawbacks. In this study, we synthesized nitrobenzene-functionalized Au 6 Cu 2 (NO 2 -Au 6 Cu 2 ) clusters, integrating metal clusters with chemical radiosensitizers. The ligand 4-nitrophenylacetylene's hypoxia-selective toxicity arises from reductase-mediated radical generation under hypoxia, depleting GSH and compromising radiotherapy ROS clearance. Our findings indicate that the electron affinity of interfacial ligands has a significant effect on the electron affinity and hypoxic cytotoxicity of metal clusters. Experimental results demonstrated that NO 2 -Au 6 Cu 2 clusters exhibit a high sensitization enhancement ratio by leveraging the properties of gold clusters to augment radiotherapy and the oxygen-mimetic property of chemical molecules to impair DNA repair pathways. This research introduces a novel strategy for developing highly efficient metal cluster-based hypoxic radiosensitizers.}, archive = {J_ANGEW}, author = {Xueli Zhao and Jingpeng Han and Junqi Liu and Zhao-Yang Wang and Xiaoyuan Chen and Shuang-Quan Zang}, doi = {10.1002/anie.202504524}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Au6Cu2 clusters with high electron affinity and oxygen-mimetic properties for hypoxic tumor radiosensitization}, volume = {64}, year = {2025}, }
• (2025). Boosting current density of electrocatalytic CO2 reduction using Metal–Enzyme hybrid cathodes. ANGEW, 64(30), e202504380. (www)

  @article{ , abstract = {As a promising solution to global warming, electrocatalytic reduction of carbon dioxide (CO 2 RR) to liquid fuel has attracted great attention. A primary challenge in industrializing CO 2 RR technologies for producing liquid fuel is the mass transfer limitation of CO 2 , which significantly reduces the current density of CO 2 RR. This study proposes a new enzyme-enhanced electrocatalysis platform for boosting CO 2 RR current density. This platform integrates an enzyme of bovine carbonic anhydrase (bCA), stabilized on carbon nanotubes (bCA@CNT), into formate/formic acid selective metal catalysts such as tin (Sn) and bismuth (Bi) to prepare Metal-bCA (M-bCA) hybrid cathodes. The incorporation of bCA enhances both the CO 2 hydration and the reversible dehydration of bicarbonate to CO 2 in the cathode. This dynamic catalysis of bCA facilitates rapid local regeneration of dissolved CO 2 from bicarbonate at the catalyst surface, thereby boosting the current density of CO 2 RR. Consequently, the formate current density of the Sn-bCA cathode was 3.3 times higher than that of the bare Sn cathode in a membrane-electrode assembly (MEA)-type cell. Furthermore, the Bi-bCA cathode achieved an excellent current density of 442 mA cm −2 , 1.5 times higher than the bare Bi cathode, for direct production of highly concentrated (3.4 mol L −1 ) formic acid in a 3-compartment cell.}, archive = {J_ANGEW}, author = {Yeomin Kang and Yunjae Kim and Youngjin Doh and Jinwoo Lee and Jungbae Kim and Ki Tae Park}, doi = {10.1002/anie.202504380}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504380}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting current density of electrocatalytic CO2 reduction using Metal–Enzyme hybrid cathodes}, volume = {64}, year = {2025}, }
• (2025). Organocatalyzed copolymerization of CO, se, and oxetane: O/Se exchange reaction determining chain structure. ANGEW, 64(30), e202504180. (www)

  @article{ , abstract = {The incorporation of selenium (Se) atoms into polymers has garnered significant interest. However, methods to introduce selenium atoms into polymers remain limited, particularly for approaches that directly utilize elemental selenium. This work presents a novel copolymerization of gaseous carbon monoxide (CO), solid Se powder, and liquid oxetane (OX) to synthesize Se-containing polymers with tunable structure, using commercially available alkyl borane and organic bases as the binary metal-free catalyst system. The polymerization process includes two steps: the reduction of CO and Se to form COSe and alternating copolymerization of COSe with OX. The O/Se exchange reaction (O/Se ER) was discovered during the polymerization, which can alter the polymer structure. The O/Se ER could be significantly suppressed by the binary organocatalyst system at 60 °C, affording well-defined poly(selenocarbonate) in a fast and selective manner. The poly(selenocarbonate) is semi-crystalline exhibiting a melting temperature of 116 °C, a number-average molecular weight of 39 kDa, a tensile strength of 5.0 ± 0.4 MPa, and an elongation of 5.5 ± 0.5%. Interestingly, the poly(selenocarbonate) could be completely converted into the poly(selenoether) by utilizing the O/Se ER, i.e., decarboxylation in the presence of organic bases at high temperatures. This work provides an efficient synthetic method for synthesizing Se-containing polymers from readily available monomers.}, archive = {J_ANGEW}, author = {Xinchen Yue and Wenqi Guo and Xiong Liu and Qinglei Yu and Xiaoxian Lu and Chengjian Zhang and Xinghong Zhang}, doi = {10.1002/anie.202504180}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504180}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organocatalyzed copolymerization of CO, se, and oxetane: O/Se exchange reaction determining chain structure}, volume = {64}, year = {2025}, }
• (2025). Emerging porous conductive ion-selective membranes for sustainable energy devices. ANGEW, 64(30), e202504134. (www)

  @article{ , abstract = {Porous conductive ion-selective membranes (PCIMs), as key components of sustainable energy devices, have attracted widespread research interest owing to their unique pore structures and properties for achieving low-resistance high-ion-selectivity transport. However, the fabrication of high-efficiency PCIMs remains challenging, and the intricate relationship between the structural properties of PCIMs and its pivotal influence on the performance of energy devices is not well explored. This review focuses on emerging PCIMs with sub-nano/nanometer pores, particularly their design strategies, and fabrication processes. First, the theorical mechanisms underlying ion transfer in confined pores is comprehensively discussed. Subsequently, the effect of a series of pore characteristics—including size, charge, geometry, orientation, and durability on ion-selective transport and their regulation strategies are discussed and summarized. Then, effective and universally known methods for designing and adjusting PCIMs containing intrinsic pores, induced pores, and composite pores are highlighted. Furthermore, the progresses of PCIM applications in emerging electrochemical energy devices including fuel cells, flow batteries, Li-ion batteries, and concentration batteries are summarized. Overall, this review aims to provide a valuable reference for scholars and researchers dedicated to the study of PCIMs, thereby contributing to the ongoing progress in this field.}, archive = {J_ANGEW}, author = {Liheng Dai and Kang Huang and Fang Xu and Shuhao Lin and Zhi Xu}, doi = {10.1002/anie.202504134}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202504134}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Emerging porous conductive ion-selective membranes for sustainable energy devices}, volume = {64}, year = {2025}, }
• (2025). In situ studies of multi-carrier dynamics in electrochemically-charged colloidal CdSe/CdS Core/Shell quantum dots. ANGEW, 64(30), e202503972. (www)

  @article{ , abstract = {The application of semiconductor nanocrystals (NCs) in optoelectronic devices and photocatalysis inevitably involves them in charged states. The carrier and exciton dynamics of electrochemically charged NCs in solutions have yet to be reported. Herein, the electrochemical charging effects in colloidal CdSe/CdS core/shell quantum dots (QDs) are systematically investigated using static spectroelectrochemistry (SEC) and in situ transient absorption (TA) spectroscopy. Static SEC reveals the presence of in-gap trap states from 0.9 eV below the conduction band (CB) edge. Negligible changes in TA spectra and kinetics were observed from open circuit potential (OCP) to more anodic potentials within the QD band gap. At cathodic potentials, the negatively charged QDs show band edge trion decay with a lifetime of 690 ± 31 ps and slower 1P to 1S electron relaxation with time constants of 12.4 ± 0.8 ps assigned to the spin blockade effect and 316 ± 35 ps assigned to the phonon bottleneck effect. Our study reveals rich effects of charging on QD excited state under nearly native conditions.}, archive = {J_ANGEW}, author = {Sheng He and Nandan Ghorai and Arun Ashokan and Sara T. Gebre and Zhicheng Yang and Tianquan Lian}, doi = {10.1002/anie.202503972}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202503972}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ studies of multi-carrier dynamics in electrochemically-charged colloidal CdSe/CdS Core/Shell quantum dots}, volume = {64}, year = {2025}, }
• (2025). Vibronic trimer design enhancing intramolecular triplet-exciton hopping to accelerate triplet-triplet annihilation for photon upconversion. ANGEW, 64(30), e202503846. (www)

  @article{ , abstract = {Photon upconversion via triplet-triplet annihilation (TTA-UC) is a well-known process that converts low-energy light into higher-energy light. This process has attracted attention for its potential in various fields, including light-emitting devices, power generation and medical applications. It is desirable to develop TTA-UC materials of TTA emitters with large TTA rate constants ( k TTA ). However, molecular design to accelerate the bimolecular rate constant of k TTA has not been considered. We present a strategy to manipulate k TTA by assembling multiple chromophores linked to a boron in a rotationally symmetric manner, causing asymmetric motions by a localized triplet exciton. We have studied tri(9-anthryl)borane, which consists of three anthracenes linked via boron, as a TTA emitter. Time-resolved luminescence measurements confirmed that k TTA is improved compared to the conventional TTA-UC system using DPA, an anthracene-based monomer. Time-resolved electron paramagnetic resonance measurements showed that the improvement in k TTA is due to fast intramolecular triplet exciton hopping coupled with vibrational motions in the trimer molecule, which extends the reactivity at the collision distance between the excitons through the pseudo-rotational motions. This molecular design that enhances TTA reactivity is expected to contribute to the future development of TTA-UC materials for sensing fluid environment.}, archive = {J_ANGEW}, author = {Kousuke Higashi and Tsubasa Okamoto and Nanami Iwaya and Eri Sakuda and Christopher W. M. Kay and Tadaaki Ikoma and Masahiro Higashi and Yasuhiro Kobori}, doi = {10.1002/anie.202503846}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202503846}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vibronic trimer design enhancing intramolecular triplet-exciton hopping to accelerate triplet-triplet annihilation for photon upconversion}, volume = {64}, year = {2025}, }
• (2025). Structural insight into a human h Ferritin@Gold-monocarbene adduct: Aurophilicity revealed in a biological context. ANGEW, 64(30), e202503778. (www)

  @article{ , abstract = {Human H ferritin (HuHf) has excellent potential as a nanocarrier for the selective delivery of anticancer metal-based drugs to tumor cells. Here, we addressed the interaction of the gold monocarbene compound Au(NHC)Cl with HuHf by electrospray ionization-mass spectrometry (ESI-MS) measurements, which provide the metalation state of the protein subunits and demonstrate the involvement of protein cysteines in gold binding. The adduct between Au(NHC)Cl and HuHf was studied by cryo-EM measurements, resulting in a high-resolution 3D density map at 1.51 Å. The cryo-EM structure shows a novel tetranuclear gold(I) cluster, located in a surface pocket of each subunit where it is bound to Cys90 and Cys102. The short inter-metal distances are diagnostic of the occurrence of aurophilic interactions. The present work demonstrates the usefulness of cryo-EM to investigate the interactions between metal-based drugs and their protein targets/carriers, also leveraging the strong signal of transition metal ions.}, archive = {J_ANGEW}, author = {Lucrezia Cosottini and Andrea Giachetti and Annalisa Guerri and Ane Martinez-Castillo and Andrea Geri and Stefano Zineddu and Nicola G. A. Abrescia and Luigi Messori and Paola Turano and Antonio Rosato}, doi = {10.1002/anie.202503778}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202503778}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural insight into a human h Ferritin@Gold-monocarbene adduct: Aurophilicity revealed in a biological context}, volume = {64}, year = {2025}, }
• (2025). Utilizing the Mn(II) dissolution-induced vacancy for optimum mg2+ storage of spinel Mn3O4. ANGEW, 64(30), e202503535. (www)

  @article{ , abstract = {Manganese-based oxide can theoretically exert the multivalent advantages of an aqueous magnesium-ion cathode due to its redox activity and abundant crystal structure. However, sluggish diffusion kinetics of Mg 2+ and Mn dissolution limit the rate performance and structure stability. Herein, we successfully utilize the notorious dissolution of Mn(II) tetrahedral site contributed vacancies for packaging optimum Mg 2+ storage of a popular spinel Mn 3 O 4 electrode. Such mechanism reverses the sluggish diffusion kinetics. Moreover, merited by the common ion effect and drug dissolution, a suitable preaddition of Mn 2+ to electrolyte inhibit Mn(III) dissolution and optimize the integrity of the spinel framework. Impressively, the cathode achieves a reversible capacity of 310 mAh g −1 and a stable cycle performance of 2000 cycles with 94.9% retention. Our research shows that reversible insertion/extraction at vacancies and effective stabilization of spinel framework is a powerful strategy to achieve Mg 2+ ion energy storage system with high rate performance and long lifespan.}, archive = {J_ANGEW}, author = {Zhongyu Pan and Zhou Jiang and Tingting Qin and Dong Wang and Fuxi Liu and He Yang and Qing Liang and Wei Zhang and Weitao Zheng}, doi = {10.1002/anie.202503535}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202503535}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Utilizing the Mn(II) dissolution-induced vacancy for optimum mg2+ storage of spinel Mn3O4}, volume = {64}, year = {2025}, }
• (2025). Palladium-catalyzed alkyl amination of olefins via radical-polar crossover at room temperature. ANGEW, 64(30), e202503446. (www)

  @article{ , abstract = {In contrast to traditional ground-state palladium-catalyzed alkyl Heck reactions, which are thermodynamically unfavorable and endothermic, excited-state palladium catalysis facilitates single-electron mechanisms, with light primarily driving the formation of alkyl radicals from triplet-state Pd(0). Here, we report a novel and mechanistically distinct Pd-catalyzed reaction, where the key hybrid alkyl Pd(I)-radical intermediate is generated by the halogen atom transfer (XAT) from alkyl bromide to the Pd(0) at room temperature, without the need for photoinitiation. This hybrid species engages in the addition to dienes and conjugated enynes, producing a transposed open-shell allyl Pd(I)-radical, which undergoes radical-polar crossover (RPC) to yield the desired products. Density functional theory (DFT) studies offer insights into the reaction mechanism, confirming the involvement of hybrid alkyl/allyl Pd(I) radical species as key intermediates.}, archive = {J_ANGEW}, author = {Anurag Singh and Kuntal Pal and Sayan Dutta and Arnab Dey and Rajesh Kancherla and Bholanath Maity and Luigi Cavallo and Magnus Rueping}, doi = {10.1002/anie.202503446}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202503446}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Palladium-catalyzed alkyl amination of olefins via radical-polar crossover at room temperature}, volume = {64}, year = {2025}, }
• (2025). Uni-electrolyte: An artificial intelligence platform for designing electrolyte molecules for rechargeable batteries. ANGEW, 64(30), e202503105. (www)

  @article{ , abstract = {Electrolytes are an essential part of rechargeable batteries, such as lithium batteries. However, electrolyte innovation is facing grand challenges due to the complicated solution chemistry and infinite molecular space (>10 60 for small molecules). This work reported an artificial intelligence (AI) platform, namely Uni-Electrolyte, for designing advanced electrolyte molecules, which mainly includes three parts, i.e., EMolCurator, EMolForger, and EMolNetKnittor. New molecules can be designed by combining high-throughput screening and generative AI models from more than 100 million alternative molecules in the EMolCurator module. The molecular properties, including frontier molecular orbital information, formation energy, binding energy with a Li ion, viscosity, and dielectric constant, can be adopted as the screening parameters. The EMolForger and EMolNetKnittor modules can predict the retrosynthesis pathway and solid electrolyte interphase (SEI) formation mechanism for a given molecule, respectively. With the assistance of advanced AI methods, the Uni-Electrolyte is strongly supposed to discover new electrolyte molecules and chemical principles, promoting the practical application of next-generation rechargeable batteries.}, archive = {J_ANGEW}, author = {Xiang Chen and Mingkang Liu and Shiqiu Yin and Yu-Chen Gao and Nan Yao and Qiang Zhang}, doi = {10.1002/anie.202503105}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202503105}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Uni-electrolyte: An artificial intelligence platform for designing electrolyte molecules for rechargeable batteries}, volume = {64}, year = {2025}, }
• (2025). Dynamic crystal-structure and active-site of defective ZnAl-catalysts during CO2 photoreduction. ANGEW, 64(30), e202502834. (www)

  @article{ , abstract = {Understanding of surface defects of a catalyst during the reaction process is critical to establish an accurate structure-activity relationship. Herein, combining operando X-ray diffraction/photoelectron spectroscopy with scanning probe microscope, we have first established the correlations between CO 2 photoreduction activities and crystal-structure/active-site of defective ZnAl layered double hydroxides (ZnAl-LDH). Specifically, the introduction of oxygen vacancies in ZnAl-LDH could effectively promote the selective adsorption of both CO 2 and H 2 O molecules on surface Al and Zn active sites, respectively, leading to opposite transition states and the evident shrinking of crystalline structures. Under light irradiation, the adsorbed CO 2 molecules transformed into *COOH intermediate on surface Al active sites, while the H 2 O molecules dissociated into OH group on Zn sites to provide proton, simultaneously leading to the expansion of crystalline structures and increase of layer spacing. Accordingly, these defect-dependent evolutions of surface active sites and crystalline structure contributed to the significant improvement of CO 2 reduction to CO activity (17.2 µmol g −1 h −1 ), much higher than that of pristine ZnAl-LDH (6.3 µmol g −1 h −1 ). This work provides new insights for in-depth understanding of the electronic and crystalline changes of defective photocatalysts during the reaction process.}, archive = {J_ANGEW}, author = {Zhengchao Wang and Rongsheng Cai and Yajun Zhang and Xiaojuan Huang and Yingpu Bi}, doi = {10.1002/anie.202502834}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202502834}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic crystal-structure and active-site of defective ZnAl-catalysts during CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Designing low-cost high-conductivity and nonflammable phosphate electrolytes toward high-energy sodium-ion batteries. ANGEW, 64(30), e202502745. (www)

  @article{ , abstract = {Safety hazard induced by flammable electrolytes are troubling the advancement of practical sodium-ion batteries (SIBs). Non-flammable phosphate electrolytes are competent to address this issue, yet current designs struggle to balance the interfacial chemistry and high ionic conductivity due to the untamed interaction between Na + and anion. Herein, we evaluate the effect of dielectric constant (DC) and binding energy ( E a ) of solvents on this interaction, revealing a systematic approach to achieve desired designs. It is shown that incorporating solvents with high DC and moderate E a forms anion-rich solvation structure for stabilizing the anode interface and achieving necessary salt dissociation for high ionic conductivity. Specifically, propylene carbonate is incorporated as the eligible solvent into triethyl phosphate, affording non-flammable electrolytes with low cost and high ionic conductivity of 6.22 mS cm −1 . Consequently, 1.25 Ah hard carbon (HC)|NaNi 1/3 Fe 1/3 Mn 1/3 O 2 (NFM) pouch cell delivers a high-power discharge of 5C rate and maintains an impressive capacity retention of 87.1% after 700 cycles at 2C rate. Moreover, 6.61 Ah HC|NFM pouch cell with 152.3 Wh kg −1 avoids smoke production and volume expansion during nail penetration. This work discloses an advanced strategy for deigning practical phosphate electrolytes, paving the way for developing high-performance SIBs.}, archive = {J_ANGEW}, author = {Mengchuang Liu and Fenfen Ma and Wei Liu and Ziqi Zeng and Yuanke Wu and Xin Chen and Shijie Cheng and Jia Xie}, doi = {10.1002/anie.202502745}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202502745}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Designing low-cost high-conductivity and nonflammable phosphate electrolytes toward high-energy sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). In situ observation of post-CO intermediates to decode C─C coupling pathways in CO2 electroreduction. ANGEW, 64(30), e202502740. (www)

  @article{ , abstract = {Electrocatalytic carbon dioxide (CO 2 ) reduction reaction (CO 2 RR) has emerged as a promising strategy for sustainable energy conversion and carbon utilization. Despite intensive research efforts, the understanding of intermediates and pathways leading from CO 2 RR to multicarbon (C 2+ ) chemicals remains incomplete. The challenge is to gain insight into the activation of adsorbed CO and the subsequent pathways. Here, we design a specially tailored Cu nanowire array facing a hydrophobic interface as an electrode to highly enhance Raman signals in the in situ environment, allowing sensitive observation of the sequential change of various elusive intermediates during CO 2 RR, such as CO, CH 2 , CO coexisting with CH 2 , CH 2 CO, and CH 3 . Density functional theory calculations reveal that the C─C coupling during CO 2 RR originates from an asymmetric coupling between CH 2 and CO to form CH 2 CO, identified as the rate-determining step in the formation of C 2+ products. These findings deepen the understanding of the C─C coupling processes, which are crucial for advancing catalyst development in electrochemical CO 2 upgrading.}, archive = {J_ANGEW}, author = {Mingxu Sun and David S. Rivera Rocabado and Jiamin Cheng and Tomohiro G. Noguchi and Masaki Donoshita and Takahiro Matsuu and Manabu Higashi and Tsuyohiko Fujigaya and Takayoshi Ishimoto and Miho Yamauchi}, doi = {10.1002/anie.202502740}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202502740}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ observation of post-CO intermediates to decode C─C coupling pathways in CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Mechanically and chemically co-robust ni-rich cathodes with ultrahigh capacity and prolonged cycle life. ANGEW, 64(30), e202502725. (www)

  @article{ , abstract = {Ni-rich layered oxide (NRLO) materials are considered highly promising cathode for lithium-ion batteries. However, their practical application is limited by capacity loss and interface instability caused by chemical and mechanical failure during cycling. Doping has been identified as a direct and effective method to address these challenges. However, mechanistic understanding of doping enhanced electrochemical performance is still unclear. In this study, the introduction of high-valent Nb ions was employed to achieve mechanical–chemical coupling regulation, thereby concurrently improving the capacity and cycle life of NRLO. First, Nb 5+ doping was conducted to refine secondary grains, achieving a “grain refinement” effect similar to that in ceramics and alloys, while further stabilizing the grain boundaries. The intergrain fusion structure of NCM811-0.5Nb effectively dissipates lattice strain under highly delithiated state, suppresses oxygen loss, and prevents cracks that lead to fracture during cycling. Moreover, Nb doping stabilizes the monoclinic phase during phase transitions and promotes the formation of highly stable spinel twin boundaries after cycling. This effectively reduces the Li diffusion barrier, leading to improved reversible specific capacity and rate capability. Lastly, the strong Nb─O bonding restrains oxygen release and transition metal/Li antisite mixing, thus mitigate rock-salt phase formation. This study demonstrates a comprehensive understanding of the concurrent capacity and stability enhancement mechanisms attributed to Nb-doping and highlights the significant potential of the synergistic regulation of mechanical and chemical coupling in improving the capacity and lifespan of NRLOs by Nb-doping.}, archive = {J_ANGEW}, author = {Bo Wang and Kuo Li and Ge Xu and Zihan Zhang and Xinxin Wang and Jun Sun and Yijun Song and Xuedong Zhang and Yali Liang and Dejie Kong and Yuan Qiu and Qipeng Teng and Xin Cui and Jingzhao Chen and Jun Zhao and Jing Wang and Hui Yang and Jianyu Huang and Yongfu Tang}, doi = {10.1002/anie.202502725}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202502725}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanically and chemically co-robust ni-rich cathodes with ultrahigh capacity and prolonged cycle life}, volume = {64}, year = {2025}, }
• (2025). Ultrahigh-voltage lithium metal batteries enabled by single-ion and weakly-solvating nanometric aggregates. ANGEW, 64(30), e202502465. (www)

  @article{ , abstract = {The urgent need for high energy density (> 400 Wh kg −1 ) has driven advancements in lithium metal batteries (LMBs) with high-voltage cathodes. However, degradation of traditional electrolytes restricts high cut-off voltage < 4.4 V, while low lithium transference numbers ( t Li + ) lead to polarization and early charge/discharge termination, which typically necessitate use of multiple solvents or salt-concentrated electrolytes to enable high-voltage chemistry. To address this challenge, we developed a single-solvent, single-salt electrolyte with tris(2,2,2-trifluoroethyl)phosphate (TFEP), achieving a high t Li + of 0.78 and enabling ultra-high-voltage LMB operation up to 5.0 V. Large molecular sterics and electron density delocalization of TFEP enabled dominant presence of local aggregates (AGGs), which further populated to form large and ion-rich weakly-solvating nanometric aggregates ( n -AGGs), changing redox properties and promoting the interfacial stabilities to a greater extent. As a result, we showed suppressed dendrite formation with stable cycling for over 1500 h, and full-cell operations paired with LiNi 0.8 Mn 0.1 Co 0.1 O 2 (NCM811) at 4.7 V and with LiNi 0.5 Mn 1.5 O 4 (LNMO) at 5.0 V. The tuning of bulk electrolyte properties from the scale of microscopic electronic structures to mesoscopic solvation structures has effectively enhanced thermodynamic and kinetic stabilities of the electrolyte, paving the way for LMBs with high-voltage tolerance.}, archive = {J_ANGEW}, author = {Chenxi Xiao and Peng Wen and Feiyu Luo and Dengxiang Yu and Huaijiao Wang and Zhirong Zhou and Weiping Li and Xinxing Zhang and Xinrong Lin}, doi = {10.1002/anie.202502465}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202502465}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrahigh-voltage lithium metal batteries enabled by single-ion and weakly-solvating nanometric aggregates}, volume = {64}, year = {2025}, }
• (2025). Lewis-base electrolyte additive mediates interfacial chemistry for stable lithium metal batteries. ANGEW, 64(30), e202502048. (www)

  @article{ , abstract = {Electrolytes play a crucial role in regulating interfacial chemistry, which is essential for the development of high-energy-density lithium metal batteries. Herein, we present an ether-based electrolyte system incorporating the simplest Grignard reagent, CH 3 MgCl, as an additive. This additive, endowed with Lewis-base characteristics, enhances the stability of the anode-electrolyte interface through bifunctional effects. During Li deposition, CH 3 Mg + preferentially adsorbs onto the electrode surface, attracting more anions into the Helmholtz layer. Concurrently, CH 3 − creates an electron-rich environment, facilitating nucleophilic attacks on anions and promoting its reduction to form an inorganic-rich solid-electrolyte interphase (SEI). Additionally, Mg 2+ undergoes electrodeposition prior to Li + , forming a Li-Mg alloy with subsequently deposited Li. This process lowers the nucleation barrier for Li deposition, resulting in improved deposition uniformity. Accordingly, the designed electrolyte demonstrates excellent cycling stability for Li anodes in both Li||Cu half-cells and full-cells paired with LiFePO 4 cathodes. Notably, Li||LiFePO 4 batteries using a thin-film Li anode pre-deposited on Cu retain ∼92.84% of their initial capacity after 300 cycles with an average Coulombic efficiency of ∼99.74%. These findings highlight the critical role of additives in engineering interfacial chemistry and provide a promising strategy for designing advanced electrolytes to improve the cycling performance of Li metal batteries.}, archive = {J_ANGEW}, author = {Rong Fang and Siyuan Ma and Lian Ding and Yu Gu and Xin Dong and Duan-Hui Si and Jing-Hua Tian and Xiu-Mei Lin and Bing-Wei Mao and Jian-Feng Li}, doi = {10.1002/anie.202502048}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202502048}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lewis-base electrolyte additive mediates interfacial chemistry for stable lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). One-step enrichment and quantitative analysis of in vivo protein complexes via dimethylpiperidine cross-linker DPST. ANGEW, 64(30), e202501845. (www)

  @article{ , abstract = {In vivo cross-linking mass spectrometry (XL-MS) enables the proteome-wide characterization of protein complexes in living cells. However, most XL-MS methods face significant sample loss during enrichment, limiting their applications to limited-quantity samples, and suffer from poor reproducibility (20%–40%), hindering precise quantification. To overcome these challenges, we developed a novel membrane-permeable cross-linker, 2,6-dimethylpiperidine disuccinimidyl tridecanoate (DPST), in which the dimethylpiperidinyl group enables one-step enrichment of cross-linked peptides via tandem mass tags (TMTs) antibody approach, eliminating sample loss from multi-step processes and allowing analysis from as few as 1E4 cells. DPST also allows the light and heavy isotopic labeling of cross-linked samples at the cellular level, which reduces inaccuracies from multi-step preparations. This generates reporter ions for precise MS2 quantification, improving the signal-to-noise ratio without increasing spectral complexity. Using DPST, we analyzed cross-links in primary neurons from single fetal mice and quantified the transient and weak interactions in dynamic liquid–liquid phase separation (LLPS) environments. Additionally, DPST's design supports multiple isotopic labeling configurations (e.g., 6-plex, 10-plex). Therefore, DPST provides a scalable and robust tool for in vivo XL-MS-based qualitative and quantitative analysis of living cells, even with limited sample quantities.}, archive = {J_ANGEW}, author = {Jing Chen and Hang Gao and Bowen Zhong and Zhou Gong and Chao Liu and Ao Zhang and Nan Zhao and Yuwen Chen and Baofeng Zhao and Zhen Liang and Yukui Zhang and Lihua Zhang and Qun Zhao}, doi = {10.1002/anie.202501845}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501845}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-step enrichment and quantitative analysis of in vivo protein complexes via dimethylpiperidine cross-linker DPST}, volume = {64}, year = {2025}, }
• (2025). Proton-conducting, vacancy-rich HxIrOy nanosheets for the fabrication of low-ionomer-dependent anode catalyst layer in PEM water electrolyzer. ANGEW, 64(30), e202501744. (www)

  @article{ , abstract = {The anode catalyst layer is composed of catalytically functional IrO x and protonic conducting ionomer and largely dictates catalytic performance of proton exchange membrane water electrolyzer (PEMWE). Here, we report a new type of anode nanocatalyst that possesses both IrO x ’s catalytic function and high proton conductivity that traditional anode catalysts lack and demonstrate its ability to construct high-performance, low-ionomer-dependent anode catalyst layer, the interior of which—about 85% of total catalyst layer—is free of ionomers. The proton-conducting anode nanocatalyst is prepared via protonation of layered iridate K 0.5 (Na 0.2 Ir 0.8 )O 2 and then exfoliation to produce cation vacancy-rich, 1 nm-thick iridium oxide nanosheets (labeled as □-H x IrO y ). Besides being a proton conductor, the □-H x IrO y is found to have abundant catalytic active sites for the oxygen evolution reaction due to the optimization of both edge and in-plane iridium sites by multiple cation vacancies. The dual functionality of □-H x IrO y allows the fabrication of low-iridium-loading, low-ionomer-dependent anode catalyst layer with enhanced exposure of catalytic sites and reduced electronic contact resistance, in contrast to common fully mixed catalyst/ionomer layers in PEMWE. This work represents an example of realizing the structural innovation in anode catalyst layer through the bifunctionality of anode catalyst.}, archive = {J_ANGEW}, author = {Lina Wang and Ruofei Du and Zicheng Zhao and Muhan Na and Xinyi Li and Xiao Zhao and Xiyang Wang and Yimin A. Wu and Subhajit Jana and Yongcun Zou and Hui Chen and Xiaoxin Zou}, doi = {10.1002/anie.202501744}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proton-conducting, vacancy-rich HxIrOy nanosheets for the fabrication of low-ionomer-dependent anode catalyst layer in PEM water electrolyzer}, volume = {64}, year = {2025}, }
• (2025). Layered-spinel heterogeneous structure and oxygen vacancies enable superior electrochemical performance for li-rich cathodes. ANGEW, 64(30), e202501539. (www)

  @article{ , abstract = {Lithium-rich manganese-based oxides (LRMOs) materials are considered to be the next-generation cathode for high-energy lithium-ion/metal batteries owing to their superior specific capacity, high operation voltage, and low cost. However, the commercial application of LRMOs is constrained by the surface structure degradation and lattice oxygen release, resulting in low initial coulombic efficiency (ICE) and rapid voltage and capacity decay. Herein, we propose a facile sorbic acid-assisted surface treatment strategy to construct homogeneous multifunctional interface layers composed of layered-spinel heterogeneous structure and oxygen vacancies on the surface of LRMOs, which enhance the structure stability and improve the activity and reversibility of the anionic oxygen redox reactions. The multifunctional interfacial layers effectively suppress irreversible oxygen release and alleviate unfavorable layered-spinel phase transformation. As a consequence, the treated LRMOs cathode displays improved ICE of 88.3%, high capacity retention rate (87.9% at 1 C after 150 cycles) and low voltage decay ratio (1.26 mV per cycle). These findings provide a valuable new idea to improve the comprehensive electrochemical performance of LRMOs through multi-strategy synergistic interface engineering techniques.}, archive = {J_ANGEW}, author = {Pengkun Yang and Long Shang and Huimin Wang and Zhenhua Yan and Kai Zhang and Yixin Li and Jun Chen}, doi = {10.1002/anie.202501539}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501539}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Layered-spinel heterogeneous structure and oxygen vacancies enable superior electrochemical performance for li-rich cathodes}, volume = {64}, year = {2025}, }
• (2025). Photoredox catalysts based on N-(Hexyl)benzothioxanthene-3,4-dicarboximide for photopolymerization and 3D printing under visible light. ANGEW, 64(30), e202501442. (www)

  @article{ , abstract = {Photoredox catalytic systems are widely used in free radical polymerization as an important photoinitiating approach. However, many reported photoredox catalytic systems are limited by their low stabilities, high excitation powers, and low initiating efficiencies upon excitation in the visible region. Therefore, it is still a great challenge to develop efficient photoinitiating systems for photopolymerization under visible light. In this work, three new effective photosensitizers from N -(hexyl)benzothioxanthene-3,4-dicarboximide derivatives, namely 2-hexyl-1 H -thioxantheno[2,1,9- def ]isoquinoline-1,3(2 H )-dione (BTXI), 5-bromo-2-hexyl-1 H -thioxantheno[2,1,9- def ]isoquinoline-1,3(2 H )-dione (BTXI-Br) and 2-hexyl-1 H -thioxantheno[2,1,9- def ]isoquinoline-1,3(2 H )-dione 6,6-dioxide (BTXIO), were designed by density functional theory calculation and synthesized as photoredox catalysts for visible light induced photopolymerization. When combined with initiators such as oxidants, that is, bis (4- tert -butylphenyl)iodonium hexafluorophosphate or sulfonium salts (i.e., thianthrenium salts, phenoxathiinium salt, phenothiazinium salt, dibenzothiophenium salt) and the reductant ethyl dimethylaminobenzoate to form three-component initiating systems, they showed good to high performance in visible light photo polymerizations with LED@405 nm and LED@450 nm. In addition, these photoinitiating systems enable the successful digital light processing and direct laser writing of 3D structures with high resolution, demonstrating a promising strategy for 3D printing applications.}, archive = {J_ANGEW}, author = {Bin Song and Yijun Zhang and Zheng Liu and Pierre Boulay and Céline Dietlin and Fabrice Morlet-Savary and Michael Schmitt and Didier Gigmes and Jean-Michel Becht and Frédéric Dumur and Jacques Lalevée}, doi = {10.1002/anie.202501442}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501442}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoredox catalysts based on N-(Hexyl)benzothioxanthene-3,4-dicarboximide for photopolymerization and 3D printing under visible light}, volume = {64}, year = {2025}, }
• (2025). Electronically asynchronous transition state tuned from remote site for oxygen atom transfer by CuII–Nitrite complexes. ANGEW, 64(30), e202501338. (www)

  @article{ , abstract = {Nitrite (NO 2 − ) reduction to nitric oxide (NO) is of paramount interest in biology. In biology, Cu–nitrite reductase reduces NO 2 − to NO, while alternatively NO 2 − can be reduced to NO at copper center via oxygen atom transfer (OAT) to electron-rich substrate like PPh 3 . This work demonstrates systematic tuning of lowest unoccupied molecular orbital (LUMO) energy by remote site modification, which leads to systematic change in electrochemical property and OAT activity of Cu II –NO 2 − involving electronically asynchronous transition state. For this purpose, we report here four Cu II –NO 2 − complexes: [Cu II (L CH2 )(NO 2 )(ClO 4 )] ( 1 ), [Cu II (L O )(NO 2 )(ClO 4 )] ( 2 ), [Cu II (L CH2 Me )(NO 2 )(ClO 4 )] ( 3 ), [Cu II (L O Me )(NO 2 )(ClO 4 )] ( 4 ) with similar primary coordination spheres but different substituents at remote sites. In going from 1 to 4 , by remote site substitution, there is systematic stabilization of LUMO energy, which correlates linearly with the increased OAT to PPh 3 resulting in 130 times reactivity enhancement for 4 compared to 1 . This kind of significant reactivity enhancement by tuning LUMO energy from remote site is very rare. Mechanistic study involving experimental and computational study reveals asynchronous mechanism that was hitherto not reported for any OAT. The observed increase in OAT reactivity from 1 to 4 is attributed to an increase in the extent of asynchronicity in corresponding transition states, which was controlled from remote site modification.}, archive = {J_ANGEW}, author = {Jyoti Devi and Anannya Saha and Suman K. Barman}, doi = {10.1002/anie.202501338}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501338}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronically asynchronous transition state tuned from remote site for oxygen atom transfer by CuII–Nitrite complexes}, volume = {64}, year = {2025}, }
• (2025). Kinetically enhanced access to a dynamic polyester platform via sequence selective terpolymerisation of elemental sulphur. ANGEW, 64(30), e202501337. (www)

  @article{ , abstract = {Elemental sulphur, a waste product of the oil refinement process, contains preformed dynamic sulphur–sulphur bonds promising to impart dynamicity onto polymers obtained from this monomer. Yet robust methodologies to access linear polymers with tuneable properties and functionality are rare. Addressing these problems, we here report a rare sequence selective terpolymerisation of elemental sulphur with aromatic thioanhydrides and epoxides under simple lithium alkoxide catalysis yields semi-aromatic poly(ester-alt-S x ). This enables access to terpolymers from a greatly improved range of epoxide comonomers compared to previous methodologies, including industrially relevant, flexible, rigid, functional and natural product-derived variants, allowing tuning of glass transition temperatures across a T g range of >150 °C. Mechanistic investigations reveal that the insertion of S 8 leads to an unusual rate acceleration via coordinative participation of the polyester links sitting adjacent to the propagating chain end. The thermal stability of the polymers allows for post polymerisation backbone modification via ─S─S─ bond metathesis. After crosslinking, these can be applied as thermally reprocessable and acid degradable adhesives. Our contribution paves the way for the rational buildup of diverse and functional polymer structures from elemental sulphur waste.}, archive = {J_ANGEW}, author = {Cesare Gallizioli and Peter Deglmann and Alex J. Plajer}, doi = {10.1002/anie.202501337}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501337}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Kinetically enhanced access to a dynamic polyester platform via sequence selective terpolymerisation of elemental sulphur}, volume = {64}, year = {2025}, }
• (2025). Selective c2 electroproduction via back bonding in asymmetric copper-copper motifs. ANGEW, 64(30), e202501254. (www)

  @article{ , abstract = {CO 2 reduction reaction (CO 2 RR) is considered a highly attractive approach to reduce carbon emissions and yet encounters challenges in further converting *C 1 intermediates to valuable two-carbon (C 2 ) products. Although copper-based catalysts exhibit satisfactory adsorption energy for *C 1 species, the symmetrical charge distribution at adjacent copper sites leads to a strong repulsive force between adsorbed *C 1 . Herein, asymmetric copper-copper (Cu F -Cu N ) motifs with distinct adsorption behaviors have been constructed on the F-Cu 3 N substrate using the in situ isostructural substitution method. Compared to the high hybridization of Cu N 3d and N 2p orbitals, implanted F not only reduces the hybridization strength but also endows the Cu F with delocalized unpaired electrons. Accordingly, Cu F , beyond forming an isolated 3d z 2 -2p z σ bond between Cu and the key *C 1 intermediate (*CHO), offers additional 3d xz -2p z π back bonding to the *CHO. With dipole interactions in the asymmetric Cu F -Cu N motifs, the electrostatic repulsion between adjacent *CHO is diminished, efficiently promoting the C-C coupling in CO 2 RR. Therefore, the Cu F -Cu N motifs achieve an exceptional C 2 selectivity of 81.5% with a partial current density of −325.9 mA cm −2 and a C 2 /C 1 selectivity ratio of 10.47. This nuanced manipulation of atomic interactions illuminates a path to potentially groundbreaking alterations in material characteristics.}, archive = {J_ANGEW}, author = {Chenchen Fang and Liming Dai and Xiaoyuan Zhang and Zhuolun Li and Yaya Wang and Xuefeng Xu and Shuo San and Kai Liu and Yuchen Fu and Junjie Cui and Jianfei Che and Pan Xiong and Yongsheng Fu and Jingwen Sun and Junwu Zhu}, doi = {10.1002/anie.202501254}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501254}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective c2 electroproduction via back bonding in asymmetric copper-copper motifs}, volume = {64}, year = {2025}, }
• (2025). Red-light-mediated generation of radicals: Applications in organic synthesis, small-molecule activation, polymerization, and bio-related fields. ANGEW, 64(30), e202501194. (www)

  @article{ , abstract = {The field of visible light-mediated photochemistry has experienced significant growth, leading to the development of a wide array of methodologies in synthetic organic chemistry. In particular, photocatalysis by using long-wavelength light such as red and near-infrared (NIR) light has garnered substantial attention. These strategies have inherent benefits of low energy, including minimal health hazards, less side reactions, and increased penetration through diverse reaction media. In this minireview, we present an overview of recent advancements in red- and NIR light-induced photocatalysis for the generation of various radicals and key intermediates in organic synthesis. Additionally, this minireview will recount the application of small-molecule activation, polymer science, and bio-related aspects to offer a comprehensive framework and insight of photochemistry mediated by red and NIR light.}, archive = {J_ANGEW}, author = {Tong Zhang and Suman Pradhan and Shoubhik Das}, doi = {10.1002/anie.202501194}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202501194}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Red-light-mediated generation of radicals: Applications in organic synthesis, small-molecule activation, polymerization, and bio-related fields}, volume = {64}, year = {2025}, }
• (2025). Hopping-type charge transport in controllably p-doped polaronic two-dimensional polymers. ANGEW, 64(30), e202500767. (www)

  @article{ , abstract = {In this work, we find that controllable p -type doping leads to Holstein-type polarons in four electron-rich two-dimensional polymers (2DPs). Substoichometrically injecting holes into these 2DPs leads to small optical bandgaps (<1.0 eV) and electrical conductivities (17 mS m −1 ) significantly higher than their undoped analogs. Fourier-transform infrared spectroscopy and continuous-wave electron paramagnetic resonance spectroscopy both reveal that this arises from the formation of paramagnetic polarons. We achieve maximal conductivities when 2DPs comprised of electron-rich nodes and electron-rich linkers are combined, which is a consequence of more delocalized polarons as unveiled by diffuse-reflectance UV–vis-NIR spectroscopy. Variable-temperature electrical conductivity measurements reveal two distinct Arrhenius regimes in all 2DPs investigated, which we attribute to the different thermally activated processes inherent to in-plane and cross-plane electronic transport in stacked 2DP multilayers. This resulted in a maximum electronic conductivity of 326 mS m −1 at an elevated temperature. Collectively, this report provides fundamental insight into polaron-based charge-transport in p -type 2D organic layers, which we expect will form the foundation for the eventual deployment of these materials in electronic devices.}, archive = {J_ANGEW}, author = {Rupam Roy and A. M. Mahmudul Hasan and Zain Becerra and Kiana A. Treaster and Anamitra Chakraborty and Garrett Baucom and Honggyu Kim and Alexander Angerhofer and Austin M. Evans}, doi = {10.1002/anie.202500767}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202500767}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hopping-type charge transport in controllably p-doped polaronic two-dimensional polymers}, volume = {64}, year = {2025}, }
• (2025). Imine Reductase–Catalyzed remote stereocontrol for enantiodivergent synthesis of cyclohexylidene-based axially chiral amines. ANGEW, 64(30), e202500572. (www)

  @article{ , abstract = {Cyclohexylidene-based amines exhibit unique axial chirality arising from the restricted double bond and have shown great potential in medicinal chemistry. However, their asymmetric synthesis remains challenging due to the long distance between the chirally relevant groups. Herein, we report a highly efficient and asymmetric synthesis of cyclohexylidene-based axially chiral amines from 4-substituted cyclohexanones and primary amines catalyzed by imine reductases (IREDs). Enantiodivergent IREDs were identified to provide convenient access to both enantiomers of chiral products with high yields and enantioselectivity (up to 99% yield, 99:1 or 1:99 enantiomeric ratio). A gram-scale synthesis of cyclohexylidene-based amines was also achieved. Moreover, protein X-ray crystallography and molecular modeling studies were conducted to provide structural insight into the remote stereocontrol of IREDs in generating cyclohexylidene-based axial chirality.}, archive = {J_ANGEW}, author = {Keting Li and Zhen Liu and Bin Wang and Ling Huang and Luyao Yu and Zitian Zhou and Liang Lin and Pengfei Fang and Haigen Fu}, doi = {10.1002/anie.202500572}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202500572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imine Reductase–Catalyzed remote stereocontrol for enantiodivergent synthesis of cyclohexylidene-based axially chiral amines}, volume = {64}, year = {2025}, }
• (2025). Scalable preparation of polyzwitterionic hydrogels based on hydration shielding-accelerated redox self-catalytic polymerization (HS-A-RP). ANGEW, 64(30), e202424129. (www)

  @article{ , abstract = {Traditional synthesis methods for polyzwitterionic hydrogels involve harsh conditions, such as thermal or UV irradiation, prolonged durations, and high monomer concentrations. Herein, we address these challenges at the meantime by proposing a novel chemical method, called hydration-shielding accelerated self-catalytic polymerization (HS-A-RP), facilitating the preparation of polyzwitterionic hydrogels. The discovery is that polyvinyl alcohol (PVA) chains can generate hydration shielding around hydrated zwitterionic monomers, promoting their effective aggregation and rapid crosslinking polymerization under the assistance of silver ions (Ag + )-potassium persulfate (S 2 O 8 2- ) redox catalyst. The HS-A-RP method performs under mild condition (−5 °C to 37 °C) without extra energy, overcomes the critical monomer polymerization concentration limitation (wt%: 0.3%), and completes within an ultrashort polymerization time (<60 s). The prepared polyzwitterionic hydrogels possesses a denser network and superior mechanical properties compared to those prepared by traditional thermal/UV methods, exhibiting good antiswelling behavior, excellent lubrication performance, and significant antibacterial and anti-fouling properties. These significant advances endow HS-A-RP with attractive application potentials in manufacturing functional hydrogel coatings for biomedical device, in situ encapsulation of thermally sensitive materials, and excellent sand fixation abilities. Moreover, HS-A-RP method is suitable for scalable manufacture and decorative coating of polyzwitterionic hydrogels on diverse substrates in extreme environmental conditions.}, archive = {J_ANGEW}, author = {Renjie Li and Lunkun Liu and Yunlei Zhang and Weiyi Zhao and Xiaoduo Zhao and Ying Liu and Bo Yu and Shuanhong Ma and Feng Zhou}, doi = {10.1002/anie.202424129}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202424129}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable preparation of polyzwitterionic hydrogels based on hydration shielding-accelerated redox self-catalytic polymerization (HS-A-RP)}, volume = {64}, year = {2025}, }
• (2025). Highly efficient and selective photocatalytic CO2 reduction to ethanol by cu4 clusters with adjacent cu single atoms anchored on carbon nitride. ANGEW, 64(30), e202423666. (www)

  @article{ , abstract = {An efficient photocatalyst for CO 2 -to-CH 3 CH 2 OH conversion comprising atomically dispersed Cu clusters (Cu 4 ) and single Cu sites coordinated with 2 N and 1 O anchored on two-step calcinated C 3 N 4 (Cu 4 /Cu 1 @CN) is reported. It was found to catalyze the reduction of CO 2 to ethanol with production rate of 154 µmol g −1 h −1 and selectivity of 98%, the yield rate and selectivity exceed most of the reported results for ethanol production. Experimental and theoretical calculations indicate that the high efficiency of this catalyst arises from the strong synergy between Cu 4 clusters and adjacent Cu single atoms, which facilitates OC─CO coupling and promotes ethanol production.}, archive = {J_ANGEW}, author = {Zhenguo Guo and Houjuan Yang and Xi Huang and Yu Ning and Hao Luo and Jianhui Xie and Jianbo He and Yingying Liu and Tai-Chu Lau}, doi = {10.1002/anie.202423666}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202423666}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient and selective photocatalytic CO2 reduction to ethanol by cu4 clusters with adjacent cu single atoms anchored on carbon nitride}, volume = {64}, year = {2025}, }
• (2025). Multivariate distribution structured anisotropic inorganic polymer composite electrolyte for long-cycle and high-energy all-solid-state lithium metal batteries. ANGEW, 64(30), e202423227. (www)

  @article{ , abstract = {Solid polymer electrolytes are promising candidates for solid-state Li metal batteries owing to their favorable rheological properties and interfacial compatibility with cathodes and Li anodes. However, their limited ionic conductivity and low modulus lead to inferior electrochemical performance and dendrite growth. Herein, we developed a composite solid-state electrolyte comprising vermiculite sheets and a poly(vinylidene fluoride) (PVDF) matrix with multivariate distribution and an anisotropic structure. Within this assembly, some vermiculite sheets were suspended in the PVDF matrix to facilitate Li salt dissociation and Li + transport, while others were tiled on the electrolyte surface, generating a dense, high-modulus Li 2 SiO 3 -rich solid electrolyte interphase via in situ electrochemical reduction, which further improved interfacial kinetics and suppressed dendrite growth. As a result, a high conductivity of 1.38 mS cm −1 was achieved at room temperature, and the Li||Li cells displayed robust stability over 3000 h. The LiNi 0.6 Co 0.2 Mn 0.2 O 2 ||Li full cells delivered a specific capacity of 172 mAh g −1 at 0.2 C and 86% capacity retention after 500 cycles at 0.5 C. Additionally, practical cycle performance at a high loading (4.4 mAh cm −2 ) was achieved in pouch cells. Overall, multivariate distribution and anisotropic structuring offers a novel perspective for the preparation of high-performance solid-state electrolytes.}, archive = {J_ANGEW}, author = {Ziqiang Yang and Bin Yang and Sen Wang and Jiasheng Qian and Zhiguo Hou and Xiaona Li}, doi = {10.1002/anie.202423227}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202423227}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multivariate distribution structured anisotropic inorganic polymer composite electrolyte for long-cycle and high-energy all-solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Photogenerated holes induced deep sodium storage of TiO2/CdSe/NFPP cathode for high-efficiency photorechargeable sodium batteries. ANGEW, 64(30), e202422732. (www)

  @article{ , abstract = {Resource-friendly photorechargeable sodium batteries (PRSBs) integrate energy storage devices with solar cells, offering a promising path for sustainable energy. Herein, a novel TiO 2 /CdSe/Na 3 Fe 2 (PO 4 )P 2 O 7 (NFPP) cathode was prepared layer-by-layer utilizing resource-abundant commercialized NFPP and photoactive CdSe. The aligned energy levels with type II band structure ensure effective transfer of photogenerated holes from CdSe (−5.71 eV) to higher valence band of NFPP (−5.10 eV). Experimental results reveal that, during charging, the induced holes in NFPP accelerate the transition of Fe 2+ to Fe 3+ with a change of O–Fe hybrid orbitals. The calculations of bond valence sum and energy distribution reveal that NFPP-holes possesses broad Na + transport path with reduced transport barrier (from 0.512 to 0.428 eV), improving Na + extraction efficiency. Additionally, photogenerated holes could regulate surface charge distribution on NFPP and thus form a film-forming agent fluoroethylene carbonate (FEC)-dominated electric double layer. Finally, it converts to a thinner (9.75 nm illumination) NaF-rich cathode interphase layer, avoiding subsequent excessive electrolyte decomposition. As a result, the NFPP under illumination delivers high capacity of 119.1 mAh g −1 at 1 C, showing 41.11% improvement compared to dark conditions.}, archive = {J_ANGEW}, author = {Mingrui Yang and Denghui Wang and Yunhua Ling and Longfei Wen and Xiaoniu Guo and Jiyu Zhang and Jiacheng Chen and Wenbin Li and Lingfei Zhao and Shunfang Li and Zhiguo Zhang and Weihua Chen}, doi = {10.1002/anie.202422732}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {30}, pages = {e202422732}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photogenerated holes induced deep sodium storage of TiO2/CdSe/NFPP cathode for high-efficiency photorechargeable sodium batteries}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Imidazo[1,5-a]pyridines – A versatile platform for structurally distinct N-heterocyclic olefins and π-extended heterocycles. ANGEW, 64(29), e202582902. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582902}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202582902}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Imidazo[1,5-a]pyridines – A versatile platform for structurally distinct N-heterocyclic olefins and π-extended heterocycles}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Self-optimizing cobalt tungsten oxide electrocatalysts toward enhanced oxygen evolution in alkaline media. ANGEW, 64(29), e202582901. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582901}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202582901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Self-optimizing cobalt tungsten oxide electrocatalysts toward enhanced oxygen evolution in alkaline media}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Staggered ABC-stacking cobalt-triptycene framework for accelerating CO2 photoreduction (Angew. chem. int. ed. 29/2025). ANGEW, 64(29), e202513693. (www)

  @article{ , archive = {J_ANGEW}, author = {Jun-Hao Wu and Xin-Hui Lu and Qian-Qian Yan and Ji-Xia Qiu and Wei Zhou and Yuan-Yuan Zhu and Xiao Wang and Sheng Zhang and Kui Li and Xing Lu}, doi = {10.1002/anie.202513693}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202513693}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Staggered ABC-stacking cobalt-triptycene framework for accelerating CO2 photoreduction (Angew. chem. int. ed. 29/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Synthesis of molecular organo-f-element-polyphosphides with non-classical divalent lanthanide precursors (Angew. chem. int. ed. 29/2025). ANGEW, 64(29), e202513690. (www)

  @article{ , archive = {J_ANGEW}, author = {David Frick and Elena Pross and Ralf Köppe and Peter W. Roesky}, doi = {10.1002/anie.202513690}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202513690}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Synthesis of molecular organo-f-element-polyphosphides with non-classical divalent lanthanide precursors (Angew. chem. int. ed. 29/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Separation of MnWOx and NaWSiOx phases boosts oxidative coupling of methane (Angew. chem. int. ed. 29/2025). ANGEW, 64(29), e202513324. (www)

  @article{ , archive = {J_ANGEW}, author = {Yu Xie and Jiawei Cheng and Wangyang Wang and Yaoyao Han and Qiyuan Fan and Hui Li and Kang Cheng and Qinghong Zhang and Ye Wang}, doi = {10.1002/anie.202513324}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202513324}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Separation of MnWOx and NaWSiOx phases boosts oxidative coupling of methane (Angew. chem. int. ed. 29/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Strongly coupled cobalt diselenide monolayers for selective electrocatalytic oxygen reduction to H2O2 under acidic conditions”. ANGEW, 64(29), e202512608. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202512608}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202512608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Strongly coupled cobalt diselenide monolayers for selective electrocatalytic oxygen reduction to H2O2 under acidic conditions”}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Enhancing cold adaptation of bidomain amylases by high-throughput computational engineering (Angew. chem. int. ed. 29/2025). ANGEW, 64(29), e202512250. (www)

  @article{ , archive = {J_ANGEW}, author = {Ning Ding and Yaoyukun Jiang and Robbie Ge and Qianzhen Shao and Wook Shin and Xinchun Ran and Zhongyue J. Yang}, doi = {10.1002/anie.202512250}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202512250}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Enhancing cold adaptation of bidomain amylases by high-throughput computational engineering (Angew. chem. int. ed. 29/2025)}, volume = {64}, year = {2025}, }
• (2025). Min zhou. ANGEW, 64(29), e202512066. (www)

  @article{ , archive = {J_ANGEW}, author = {Min Zhou}, doi = {10.1002/anie.202512066}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202512066}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Min zhou}, volume = {64}, year = {2025}, }
• (2025). Dawid lichosyt. ANGEW, 64(29), e202510161. (www)

  @article{ , archive = {J_ANGEW}, author = {Dawid Lichosyt}, doi = {10.1002/anie.202510161}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202510161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dawid lichosyt}, volume = {64}, year = {2025}, }
• (2025). Surface work function-induced high-entropy solid electrolyte interphase formation for highly stable potassium metal anodes. ANGEW, 64(29), e202509252. (www)

  @article{ , abstract = {The failure of the solid electrolyte interphase (SEI) layer is a key issue limiting the practical application of potassium metal batteries. Herein, a novel high-entropy SEI layer rich in inorganic components is designed and constructed via in situ electrochemical conversion of the Sn 3 O 4 /Sn 2 S 3 interfacial layer on a porous scaffold. Theoretical studies and experimental techniques reveal that the Sn 3 O 4 /Sn 2 S 3 heterostructure, with its low work function and weak Sn─O/S bond, significantly enhances reactivity with the electrolyte, thereby facilitating the in situ formation of the high-entropy SEI layer. The in situ generated high-entropy SEI exhibits low surface roughness, low surface potential, fast potassium ion transport characteristics, and excellent mechanical properties (Young's modulus of 20.08 GPa). Leveraging these advantageous properties of the high-entropy SEI, the resulting potassium metal anode achieves an excellent rate performance up to 10 mA cm −2 in symmetric cells and demonstrates outstanding cycling stability for 2500 h at 0.5 mA cm −2 . When paired with a perylene-3,4,9,10-tetracarboxylic dianhydride cathode, the potassium metal full battery retains 81.6% of its capacity over 1650 cycles at 10 C. This work underscores a straightforward and effective approach for the establishment of a stable interphase on metallic potassium anodes.}, archive = {J_ANGEW}, author = {Lili Song and Qiaoxi Yang and Yu Yao and Mengran Tan and Renke Li and Jiaying Liao and Xiaosi Zhou and Yan Yu}, doi = {10.1002/anie.202509252}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202509252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface work function-induced high-entropy solid electrolyte interphase formation for highly stable potassium metal anodes}, volume = {64}, year = {2025}, }
• (2025). Heavy-atom-free supramolecular photosensitizers derived from conventional fluorophores. ANGEW, 64(29), e202508968. (www)

  @article{ , abstract = {Heavy-atom-free photosensitizers (PSs) offer advantages such as efficient generation of reactive oxygen species (ROS), low dark cytotoxicity, good photostability, and high biocompatibility. Although the development of new PSs through organic synthesis has been a focus of active research, supramolecular chemistry offers a complementary pathway. This study presents a versatile supramolecular strategy to convert conventional fluorophores into heavy-atom-free PSs using a cyclic peptide-based scaffold that densely assembles fluorophore moieties. Results demonstrate that supramolecular PSs constructed from four synthetic fluorophore types—cyanines, coumarins, rhodamines, and BODIPYs—exhibit a remarkable enhancement in ROS generation efficiency, attributed to the increased intersystem crossing efficiency induced by self-assembly. Moreover, these supramolecular PSs function as visible-light photocatalysts, efficiently regenerating NAD + from NADH. The densely packed polymer shell further shields enzymes from ROS-induced deactivation, thereby facilitating the development of robust photoenzyme catalytic systems. This study not only enriches the design methodology of heavy-atom-free PSs, but also paves the way for eco-friendly photobiocatalytic systems.}, archive = {J_ANGEW}, author = {Lingfeng Fan and Yong Wu and Cong-Qiao Xu and Hanqiu Jiang and Zhenhua Xie and Yubin Ke and Jun Li and Qiao Song}, doi = {10.1002/anie.202508968}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508968}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heavy-atom-free supramolecular photosensitizers derived from conventional fluorophores}, volume = {64}, year = {2025}, }
• (2025). “Electricity”-assisted catalytic solar-to-fuel processes. ANGEW, 64(29), e202508809. (www)

  @article{ , abstract = {Efficient conversion of solar energy into chemical fuels is pivotal for establishing sustainable energy systems, yet persistent challenges in carrier dynamics and reaction selectivity hinder practical implementation. This review systematically examines the emerging paradigm of “electricity” assisted solar-to-fuel catalysis, innovatively proposing a dual-path framework based on distinct electrical intervention mechanisms: Cross-Space Charge Transfer System and Local Electric Field Regulation System, elucidating their unique roles in bridging light absorption and fuel synthesis. In the former, the charge transfer driven by external bias enhances the separation of photogenerated charges in single photoelectrode photoelectrocatalysis (PEC), while the self-powered dual photoelectrodes PEC-PEC, photovoltaic-photoelectrocatalysis (PV-PEC), and photovoltaic-electrocatalysis (PV-EC) systems achieve zero energy conversion from solar energy to fuel through band matching and device integration, utilizing charge transfer driven by photogenerated potential. In the latter, static intrinsic electric field (ferroelectric spontaneous polarization electric field and interface electric field) and dynamic electric field (piezoelectric, pyroelectric, flexoelectric, and triboelectric induced transient electric field) optimize carrier transport dynamics and accelerate reactant adsorption. This article systematically summarizes the promotion of diverse forms of “electricity” on solar-to-fuel catalysis, reveals the energy conversion mechanisms, material design principles, performance bottlenecks, and solutions of different systems, providing insights into the development of this field.}, archive = {J_ANGEW}, author = {Pengwei Jia and Yutang Yu and Tong Chen and Hongwei Huang}, doi = {10.1002/anie.202508809}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508809}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Electricity”-assisted catalytic solar-to-fuel processes}, volume = {64}, year = {2025}, }
• (2025). Intramolecular switching oxygen reduction reaction driven by dual-crystalline bimetallic MOF induces self-potential-resolved electrochemiluminescence biosensor. ANGEW, 64(29), e202508627. (www)

  @article{ , abstract = {Framework materials, particularly metal–organic frameworks (MOFs), have emerged as versatile platforms for multifunctional applications due to their tunable structures and properties. In this study, a series of bimetallic ZnRuMOFs with dual-crystalline phase structure was designed and synthesized. This unique dual-crystalline bimetallic MOF configuration enables intramolecular autocatalysis and selective oxygen reduction reaction (ORR). By utilizing endogenous dissolved O 2 as a green co-reactant, an electrochemiluminescence (ECL)-coupled ORR system with potential-resolving capability was developed. Experimental results, supported by density functional theory (DFT) calculations, elucidated the ability of MOFs with different phase structures to catalyze specific reactive oxygen species (ROS) generation and the mechanism of ECL luminescence mediated by intramolecular autocatalysis using ZnRuMOF as the luminophore. The selectively generated ROS function as intramolecular coreactants, reducing radical transfer losses and significantly enhancing ECL stability. Leveraging these findings, a novel potentiometrically resolved ECL biosensor for the cardiovascular disease biomarker microRNA 24 was constructed. The biosensor integrates ROS-mediated intramolecular modulation with a platinum single-atom catalysts (Pt-N-SAC). This study demonstrates that precise modulation of MOF structures reveals distinct catalytic properties associated with different MOF configurations, offering a new strategy for the development of simple yet efficient monoluminescent ECL systems.}, archive = {J_ANGEW}, author = {Junchuan Qin and Jinyu Zhou and Jiajia Chen and Pengcheng Gu and Yiwu Wang and Zeying Li and Yehanrui Chen and Chenglin Dai and Wenkai Ying and Xin Pu and Guangchao Zang and Shu Zhu}, doi = {10.1002/anie.202508627}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intramolecular switching oxygen reduction reaction driven by dual-crystalline bimetallic MOF induces self-potential-resolved electrochemiluminescence biosensor}, volume = {64}, year = {2025}, }
• (2025). Branched alkyl chains tunable organic-inorganic hybrid manganese halides for anti-counterfeiting, white light-emitting diode and X-ray imaging applications. ANGEW, 64(29), e202508536. (www)

  @article{ , abstract = {Manganese-based organic–inorganic metal halides (Mn-based OIMHs) scintillators have aroused a research upsurge due to their outstanding photoluminescence performance, low toxicity, and tunable structures. Herein, we demonstrate a molecular engineering strategy that synergistically enhances luminescence efficiency and radiation sensitivity by systematic elongation of branched alkyl chains in phosphonium-based cations. The (4-DEATBP)MnBr 4 (4-DEATBP = (4-(diethylamino)butyl)triphenylphosphonium) crystal exhibits remarkable thermochromic luminescence properties and anti-thermal quenching effect, highlighting the application potential in high-temperature anti-counterfeiting and information encryption. Through effective chain elongation, the (4-DBATBP)MnBr 4 (4-DBATBP = (4-(dibutylamino)butyl)triphenylphosphonium) single crystal achieves an impressive photoluminescence quantum yield (PLQY) of 100% and exhibits superior performance under X-ray irradiation, with a high light yield of 67953 photons MeV −1 and a low limit of detection (LOD) of 10.45 nGy s −1 . Additionally, the glassy (4-DBATBP)MnBr 4 demonstrates an impressive spatial resolution of 25 lp mm −1 . (4-DBATBP)MnBr 4 shows great application potential in the fields of white light-emitting diode (WLED) and express security check due to its outstanding luminescence performance. This work not only offers two kinds of new Mn-based OIMH materials but also authenticates the role of extending the branched alkyl chain for improving the photoluminescence performance.}, archive = {J_ANGEW}, author = {Jing-Hua Chen and Jian-Bin Luo and Qing-Peng Peng and Zi-Lin He and Jun-Hua Wei and Dai-Bin Kuang}, doi = {10.1002/anie.202508536}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508536}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Branched alkyl chains tunable organic-inorganic hybrid manganese halides for anti-counterfeiting, white light-emitting diode and X-ray imaging applications}, volume = {64}, year = {2025}, }
• (2025). Engineered spatial confinement of cu single-atoms with diagonal N─Cu─N motifs for high-rate CO2 methanation. ANGEW, 64(29), e202508497. (www)

  @article{ , abstract = {The renewable-electricity-powered carbon dioxide reduction (eCO 2 R) to value-added fuels and feedstocks like methane (CH 4 ) holds the sustainable and economically viable carbon cycle at meaningful scales. However, this kinetically challenging eight-electron multistep deep-reduction encounters insufficient catalyst design principles to steer complex CO 2 reduction pathways. Utilizing atomic copper (Cu) structures with unitary active sites can boost eCO 2 R-to-CH 4 selectivity due to the efficient suppression of unwanted C─C coupling. Herein, we report a sequential ion exchange strategy to fabricate periodic Cu single-atom catalysts within a polymeric carbon nitride (PCN) matrix, where the uniformly dispersed, diagonally coordinated N─Cu─N configuration hosts low-valent Cu δ+ centers. Leveraging the periodic N-anchoring sites with delocalized π-electron conjugation in the PCN matrix, the isolated Cu sites are obtained with an interatomic distance of ∼4.2 Å under high metal-loading conditions. This engineered spatial configuration effectively inhibits C─C coupling to avoid subsequent multicarbon product formation. The optimized Cu 1 /PCN demonstrates exceptional eCO 2 R-to-CH 4 performance, achieving 71.1% CH 4 Faradaic efficiency with a high partial current density of 426.6 mA cm −2 at −1.50 V versus reversible hydrogen electrode, outpacing the state-of-the-art catalysts. This work delves into effective concepts for steering desirable reaction pathways via precisely modulating active site structures at the atomic level to create favorable microenvironments.}, archive = {J_ANGEW}, author = {Guanghui Feng and Dashuai Wang and Libin Zeng and Wanzhen Zheng and Weixiao Lin and Xianyun Peng and Xiahan Sang and Bin Yang and Zhongjian Li and Yuanyuan Li and Lecheng Lei and Yang Hou}, doi = {10.1002/anie.202508497}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508497}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered spatial confinement of cu single-atoms with diagonal N─Cu─N motifs for high-rate CO2 methanation}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic boron insertion into thiaarenes via boryl radicals. ANGEW, 64(29), e202508379. (www)

  @article{ , abstract = {Skeletal editing of aromatic heterocycles represents a straightforward approach to rapidly expand the accessible chemical space. While notable progress has been made on the direct modification of various nitrogen- and oxygen-heterocycles, editing of prevalent sulfur-containing heteroarenes, especially for single-atom insertion, remains exceedingly rare. This disparity is primarily attributed to the sulfur atom's inherent nucleophilicity and high susceptibility to oxidation. Here we present a conceptually distinct photocatalytic strategy that enables the insertion of a boron atom into a diverse range of thiaarenes, furnishing previously inaccessible cyclic thioborane scaffolds and synthetically valuable alkyl boronates in an efficient manner. Furthermore, mechanistic studies have revealed that the boron insertion step proceeds through an unprecedented mechanism.}, archive = {J_ANGEW}, author = {Yubing Pang and Ermeng Wang and Juntao Ye}, doi = {10.1002/anie.202508379}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508379}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic boron insertion into thiaarenes via boryl radicals}, volume = {64}, year = {2025}, }
• (2025). Achieving uniform phase structure for layer-by-layer processed binary organic solar cells with 20.2% efficiency. ANGEW, 64(29), e202508257. (www)

  @article{ , abstract = {Layer-by-layer (LBL) deposition has become a facile and promising method to fabricate highly efficient organic solar cells (OSCs). However, characterization and optimization of 3D morphology remain a grand challenge for LBL-processed active layers, and their correlation with photovoltaic properties of OSC devices is not clear to date. Here, to address this issue, the morphology and its formation mechanisms of LBL-processed active layer based on the classical D18/L8-BO blend were investigated systematically. Intriguingly, a unique 3D nanomorphology is achieved and uncovered within the LBL processed active layer, which highlights a highly uniform and “zigzag”-shaped phase structure formed by the intersection of donor and acceptor aggregates along horizontal direction in the middle-depth layer, rarely found in bulk heterojunction (BHJ) films processed by blend casting. Our results revealed that solid additive DBM with a twisted conformation plays a crucial role in achieving the uniform phase structure of LBL-deposited active layer. Consequently, the characteristic 3D morphology of LBL-processed device significantly improves short-circuit current and fill factor, enabling an impressive PCE of 20.2% in such binary device. Therefore, this work unambiguously demonstrates a unique 3D nanomorphology within LBL active layer, unveils the morphology manipulation mechanism, and their correlation with optoelectronic properties of OSCs.}, archive = {J_ANGEW}, author = {Hao Wang and Busheng Zhang and Liming Wang and Xia Guo and Le Mei and Bo Cheng and Wei Sun and Lixuan Kan and Xinxin Xia and Xiaotao Hao and Thomas Geue and Feng Liu and Maojie Zhang and Xian-Kai Chen}, doi = {10.1002/anie.202508257}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508257}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving uniform phase structure for layer-by-layer processed binary organic solar cells with 20.2% efficiency}, volume = {64}, year = {2025}, }
• (2025). Selenite-directed Organotin–Oxo macrocycles for nanolithography. ANGEW, 64(29), e202508220. (www)

  @article{ , abstract = {The systematic design of organotin–oxo macrocycles with enhanced extreme ultraviolet (EUV) photon-harvesting capability and sub-50 nm lithographic resolution remains a pivotal challenge in advancing nanofabrication technologies. Herein, we present a novel series of polynuclear n butyltin–oxygen macrocycles— Sn 8 , Sn 12 -α , Sn 12 -β , and Sn 12 Fe 18 —constructed through selenite ligand-driven supramolecular assembly. Among these, Sn 12 -α demonstrated exceptional electron beam lithography (EBL) performance, achieving a critical dimension resolution of 50 nm at a low dose of 50 µC·cm −2 , attributed to its elevated Sn/Se content, compact molecular architecture (diameter, 1.5 nm), and excellent film-forming ability (surface roughness, 0.59 nm). By replacing conventional carboxylate ligands with inorganic selenite, this study addresses longstanding limitations in structural versatility and EUV absorption efficiency inherent to traditional organotin–oxo systems. These findings establish a paradigm for engineering metal–oxide photoresists through ligand-driven cluster dimensionality control, offering a scalable pathway to high-sensitivity, high-resolution patterning for next-generation semiconductor manufacturing.}, archive = {J_ANGEW}, author = {Juan Wang and Ming-Bu Luo and Zi-Juan Wei and Er-Xia Chen and Jin-Xia Yang and Jian Zhang and Qipu Lin}, doi = {10.1002/anie.202508220}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508220}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selenite-directed Organotin–Oxo macrocycles for nanolithography}, volume = {64}, year = {2025}, }
• (2025). Modeled single-atomic-site pt catalyst with well-defined coordination structure for hydrosilylation reaction. ANGEW, 64(29), e202508064. (www)

  @article{ , abstract = {Single-atom-site (SAS) catalysts exhibit superior activity in catalytic reactions, and their isolated active sites are anticipated to serve as an ideal platform for mechanistic investigations. However, the coordination environment of SAS catalyst synthesized via pyrolysis is challenging to control, and the active sites are randomly distributed, posing challenges for structure-activity relationship studies. Therefore, the development of model catalysts featuring well-defined coordination structures remains highly desirable but challenging. Herein, a Pt 1 C 48 H 61 P 2 Cl SAS catalyst is synthesized by an in situ reduction-assembly strategy, serving as a modeled Pt-SAS catalyst with a precisely defined coordination structure. The structure is confirmed as Pt-P 2 C 1 Cl 1 by single-crystal X-ray diffraction and X-ray absorption spectroscopy. Under solvent-free conditions, this catalyst achieves 98% conversion and >99% selectivity in anti-Markovnikov alkene hydrosilylation within 1 h and can exhibit good recyclability. Density functional theory (DFT) calculations revealed that the synthesized Pt-SAS catalyst exhibits a significantly reduced free energy barrier for the hydrosilylation reaction compared to the traditional Pt (111) surface, which can be attributed to weaker interactions during the oxidative addition step, enabling easier product desorption.}, archive = {J_ANGEW}, author = {Mengge Lu and Xuxin Kang and Changjin Qian and Kaiyue Wang and Xiaoyang Ren and Ruhao Wang and Kai Sun and Zheng Chen and Xiangmei Duan and Shubo Tian}, doi = {10.1002/anie.202508064}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508064}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modeled single-atomic-site pt catalyst with well-defined coordination structure for hydrosilylation reaction}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of isodaphlongamine h by iridium-catalyzed reductive [3 + 2] cycloaddition of N-hydroxylactam. ANGEW, 64(29), e202508062. (www)

  @article{ , abstract = {The total synthesis of isodaphlongamine H based on a lactam strategy, which enables quick access to complex cyclic amines, is described. The strategy begins with alkylation of a chiral lactam and subsequent N -oxidation via an imino ether to afford the N -hydroxylactam. For the key transformation to functionalize the amide carbonyl, an iridium-catalyzed reductive [3 + 2] cycloaddition of the N -hydroxylactam provides a tricyclic isoxazolidine in a one-pot process. After the coupling reaction with an allylic silane fragment, the total synthesis is accomplished through intramolecular Hosomi–Sakurai allylation to construct a pentacyclic core. The deoxygenated pentacyclic intermediate shows higher cytotoxicity against HeLa and U937 cell lines than isodaphlongamine H, and might become a lead compound for further biological study.}, archive = {J_ANGEW}, author = {Sora Iwamoto and Reki Nakano and Keiji Sasaki and Shoichiro Kobayashi and Yuki Taira and Koya Takei and Reiji Kawakita and Ayako Tokuyama and Haruto Nakamura and Manato Tomoike and Ryota Kawahara and Akari Murase and Siro Simizu and Noritaka Chida and Toshitaka Okamura and Takaaki Sato}, doi = {10.1002/anie.202508062}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202508062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of isodaphlongamine h by iridium-catalyzed reductive [3 + 2] cycloaddition of N-hydroxylactam}, volume = {64}, year = {2025}, }
• (2025). Fluorinated covalent organic framework membranes with robust wetting resistance for durable membrane distillation. ANGEW, 64(29), e202507913. (www)

  @article{ , abstract = {Membrane distillation (MD) is a promising separation technique for producing pure water from brine using low-grade heat. Covalent organic framework (COF) membranes with high porosity and well-ordered pore structure exhibit excellent flux and salt rejection during MD. However, long-term MD operation is often restricted by the inevitable gradual wetting of COF membranes, which causes deterioration of salt rejection, primarily resulting from the lack of intrinsic hydrophobicity. Herein, a fluorinated COF (TGTf) membrane with intrinsic hydrophobicity and excellent anti-wetting property is reported. Under 65 °C and 12 kPa operation pressure, the TGTf membrane maintained a high water flux of 195 L m −2 h −1 and a salt rejection of 99.80% over 168 h of MD operation, which is the longest operation time ever reported for MD using COF membranes. In addition, the TGTf membrane showed unparalleled resistance to scaling and organic fouling, demonstrating great potential for real-world brine treatment. Experimental and simulation studies revealed that incorporation of fluorine atom not only enhanced the hydrophobicity of the COF membrane, but also created electrostatic barriers within the fluorinated nanochannels, efficiently preventing ion penetration. These results underscore the remarkable potential of fluorinated COF membranes in MD, offering a promising solution for sustainable brine desalination.}, archive = {J_ANGEW}, author = {Shuai Wang and Lishuang Gui and Di Qiao and Meiling Tao and Shilin Huang and Xuelin Tian}, doi = {10.1002/anie.202507913}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorinated covalent organic framework membranes with robust wetting resistance for durable membrane distillation}, volume = {64}, year = {2025}, }
• (2025). Promoting the intermediates hydrogenation for urea electrosynthesis over an “Active hydrogen pump” catalyst. ANGEW, 64(29), e202507869. (www)

  @article{ , abstract = {Electrocatalytic coupling of CO 2 and NO 3 − offers a sustainable approach for urea production. However, the limited supply of active hydrogen (*H) hinders the formation of the key carbon- and nitrogen-containing intermediates, thus impeding the selective C─N coupling. Herein, we developed copper molybdate (Cu 3 Mo 2 O 9 ) nanorods, which could serve as “active hydrogen pump” catalysts by regulating the water dissociation and hydrogen adsorption. Such electrocatalyst would guarantee a steady *H supply for intermediates hydrogenation, hence boosting the generation of *CO and *NH 2 intermediates for selective C‒N coupling and urea production. In a CO 2 -saturated 0.1 M KNO 3 solution, Cu 3 Mo 2 O 9 achieved a maximum urea yield rate of 177 mmol h −1 g −1 with a urea-producing FE of 40% in a flow cell configuration, outperforming most reported electrocatalysts. This study underscores the crucial role of *H, which may guide the exploration of advanced catalysts for expediting the sustainable synthesis of indispensable chemicals requiring rapid intermediates hydrogenation.}, archive = {J_ANGEW}, author = {Chu Zhang and Quan Zhou and Zeyu Li and Chunshuang Yan and Hengjie Liu and Daobin Liu and Li Song and Qingyu Yan and Chade Lv}, doi = {10.1002/anie.202507869}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting the intermediates hydrogenation for urea electrosynthesis over an “Active hydrogen pump” catalyst}, volume = {64}, year = {2025}, }
• (2025). Nitramine formation via a cryptic non-ribosomal peptide synthetase-dependent strategy in N-nitroglycine biosynthesis. ANGEW, 64(29), e202507866. (www)

  @article{ , abstract = {N -nitroglycine (NNG), a rare nitramine natural compound, is the only known example produced by streptomyces strains. In this study, we clarified that NNG biosynthesis originates from glycine and l -lysine and elucidated its biosynthetic gene cluster (BGC) nng . This cluster shares high homology with the recently reported BGCs of diazo compound azaserine. In vivo and in vitro results have indicated NNG biosynthetic pathway involves hydrazine and hydrazone generation, with a non-heme diiron N -oxygenase and a cytochrome P450 responsible for forming the nitramine structure. Furthermore, although NNG lacks a serine unit in the structure, its biosynthesis still requires the incorporation of a serine attached to the hydrazone intermediate by non-ribosomal peptide synthetase (NRPS), similar to the azaserine pathway, and two hydrolases are putatively involved in thioester hydrolysis and serine removal, respectively. This study, along with comparisons to azaserine biosynthesis, not only paves the way for the discovery of new nitramine and diazo compounds by genome mining but also highlights the potential for uncovering novel enzymes and chemistry involved in hydrazone oxidation.}, archive = {J_ANGEW}, author = {Yun Wang and Jiangtao Zhang and Ran Shi and Siyuan Zhou and Shigui Chen and Ruofei Li and Wei Huang and Hai-Yan He}, doi = {10.1002/anie.202507866}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507866}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitramine formation via a cryptic non-ribosomal peptide synthetase-dependent strategy in N-nitroglycine biosynthesis}, volume = {64}, year = {2025}, }
• (2025). Green electrosynthesis of hydroxylamines via CuS suppressing N─O bond cleavage. ANGEW, 64(29), e202507853. (www)

  @article{ , abstract = {Organic hydroxylamines, pivotal intermediates in pharmaceutical and polymer chemistry, face persistent challenges in selective synthesis. Its main difficulty lies in the strong repulsion between the lone pair electrons on the N and O atoms, which makes their N─O bond easy to break, leading to a over-reduction to amine compounds. Here, we present a green electrocatalytic strategy for the first time that converts oximes to hydroxylamines over CuS. Specially, N -benzylhydroxylamine was achieved with 95% conversion and 80% selectivity from benzaldoxime at −0.9 V versus reversible hydrogen electrode. Mechanistic investigations reveal that CuS can optimize the adsorption energy of the reaction intermediates, making the N─O bond more difficult to cleave during the electrocatalytic hydrogenation, thus leading to a high selectivity formation of hydroxylamines. This methodology is successfully extended to other hydroxylamines and further enables the unprecedented synthesis of organic hydroxylamines from nitric oxide gas. Our work establishes a sustainable electrosynthetic platform for hydroxylamines synthesis without organic solvents and additional reduction agents, providing new insights for modern green chemical synthesis.}, archive = {J_ANGEW}, author = {Suisheng Li and Peisen Liao and Jiacheng Li and Pingping Jiang and Runan Xiang and Guangqin Li}, doi = {10.1002/anie.202507853}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507853}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Green electrosynthesis of hydroxylamines via CuS suppressing N─O bond cleavage}, volume = {64}, year = {2025}, }
• (2025). Deep supramolecular language processing for co-crystal prediction. ANGEW, 64(29), e202507835. (www)

  @article{ , abstract = {Approximately 40% of marketed drugs exhibit suboptimal pharmacokinetic profiles. Co-crystallization, where pairs of molecules form a multicomponent crystal, constitutes a promising strategy to enhance physicochemical properties without compromising the pharmacological activity. However, finding promising co-crystal pairs is resource-intensive due to the large and diverse range of possible molecular combinations. We present DeepCocrystal, a novel deep learning approach designed to predict co-crystal formation by processing the “chemical language” from a supramolecular vantage point. Rigorous validation of DeepCocrystal showed a balanced accuracy of 78% in realistic scenarios, outperforming existing models. Explainable AI approaches uncovered the decision-making process of DeepCocrystal, showing its capability to learn chemically relevant aspects of the “supramolecular language” that match experimental co-crystallization patterns. By leveraging properties of molecular string representations, DeepCocrystal can also estimate the uncertainty of its predictions. We harnessed this capability in a challenging prospective study and successfully discovered two novel co-crystals of diflunisal, an anti-inflammatory drug. This study underscores the potential of deep learning—and in particular of chemical language processing—to accelerate co-crystallization and ultimately drug development, in both academic and industrial contexts. DeepCocrystal is available as an easy-to-use web application at https://deepcocrystal.streamlit.app/ .}, archive = {J_ANGEW}, author = {Rebecca Birolo and Rıza Özçelik and Andrea Aramini and Roberto Gobetto and Michele R. Chierotti and Francesca Grisoni}, doi = {10.1002/anie.202507835}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507835}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deep supramolecular language processing for co-crystal prediction}, volume = {64}, year = {2025}, }
• (2025). Tuning the crystallization and photothermal aging chemistry of CsPb0.4Sn0.6I3 for inorganic perovskite tandem photovoltaics. ANGEW, 64(29), e202507761. (www)

  @article{ , abstract = {The poor performance of inorganic narrow bandgap perovskite solar cells (PSCs) hinders the development of inorganic perovskite tandem solar cells (IPTSCs). We modulate the crystallization and photothermal aging chemistry for CsPb 0.4 Sn 0.6 I 3 (1.31 eV) with guanidinoacetic acid (GCA) to develop IPTSC. The CsPb 0.4 Sn 0.6 I 3 :GCA PSC reaches an efficiency of 16.93% and maintains an initial efficiency of ∼80% ( T 80 ) for 1300 h under maximum power point tracking (MPPT) at 65 °C. We identify that there are not only ionic migration species (I − , I 3 − ) but also molecular migration species (SnI 4 , I 2 ) for CsPb 0.4 Sn 0.6 I 3 correlated to the photothermal dynamics. For CsPb 0.4 Sn 0.6 I 3 film, the intractable pinholes accelerate the iodine migration to the electrode and photothermal degradation. The photodegradation of PbI 2 produces I 2 and then promotes the Sn 2+ oxidation to Sn 4+ , causing tin migration in the form of SnI 4 to accumulate at the electron transport layer/perovskite interface, and in turn generating more pinholes and Sn-Pb segregation. In CsPb 0.4 Sn 0.6 I 3 :GCA film, due to the coordination bonds with Pb/Sn cations and hydrogen bonds with I − ions, GCA incorporation-induced pinhole-free morphology can significantly suppress ion/molecule migration. Combined with CsPbI 2 Br subcell, two-terminal IPTSC delivers an efficiency of 22.18%, accompanied by T 80 = 850 h under MPPT at 65 °C.}, archive = {J_ANGEW}, author = {Chenghao Duan and Mingyu Hu and Qiliang Zhu and Shiang Li and Ning Liu and Zheng Zhang and Liming Ding and Jianhang Qiu and Lin Guo and Xinhui Lu and Shihe Yang and Keyou Yan}, doi = {10.1002/anie.202507761}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507761}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning the crystallization and photothermal aging chemistry of CsPb0.4Sn0.6I3 for inorganic perovskite tandem photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Asymmetric intramolecular α-arylation of polar amino acids bearing β-leaving groups. ANGEW, 64(29), e202507713. (www)

  @article{ , abstract = {The α-arylation of amino acids may be achieved by intramolecular nucleophilic aromatic substitution (S N Ar) reactions of amino-acid derived enolates, but for amino acids bearing β-leaving groups, such reactions are complicated by competing E1cB elimination of the β-substituent. In this paper we report an approach to the arylation of the polar amino acids serine, cysteine, diaminopropionic acid, and allothreonine by inducing intramolecular S N Ar reactions of heterocycles, which the heteroatom substituent is stereoelectronically protected from elimination by incorporating it into the ring system of N -carbamoyl oxazolidines, thiazolidines, or imidazolidines. The sequence comprises the diastereoselective formation of a heterocyclic urea followed by an intramolecular N-to-C aryl migration, yielding bicyclic hydantoins that can be further hydrolysed to afford quaternary α-aryl amino acids. The method is practical and scalable, avoids the use of transition metals or chiral auxiliaries, and provides the opportunity to access a variety of α-arylated products bearing electronically diverse benzenoid or heterocyclic substituents (35 examples).}, archive = {J_ANGEW}, author = {Ömer Taspinar and Daniel J. Leonard and Nathan Picois and Cornelia Göcke and Matej Žabka and Hazel A. Sparkes and Jonathan Clayden}, doi = {10.1002/anie.202507713}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507713}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric intramolecular α-arylation of polar amino acids bearing β-leaving groups}, volume = {64}, year = {2025}, }
• (2025). Narrow-band dibenzoselenophene-based emitter with rapid triplet conversion for versatile OLED applications with superior roll-off suppression. ANGEW, 64(29), e202507626. (www)

  @article{ , abstract = {Selenium-containing multiple resonance thermally activated delayed fluorescence (MR-TADF) materials with ultra-fast reverse intersystem crossing (RISC) have emerged as a promising solution for mitigating efficiency roll-off in organic light-emitting diodes (OLEDs). In this work, we introduce DBSeBN, the first MR-TADF emitter incorporating a rigid five-membered dibenzoselenophene unit. This design simultaneously achieves a narrow full width at half maximum of 23 nm across a wide range of doping concentrations in films, along with an ultra-fast RISC rate of 1.1 × 10 7 s −1 , which is two orders higher than that of its sulfur-containing counterpart, DBTBN, due to the enhanced spin-orbit coupling via the heavy atom effect of selenium. As an OLED emitter, DBSeBN demonstrates exceptional performance, achieving a maximum external quantum efficiency of 31.6% and retaining 23.3% at 1000 cd m −2 , surpassing DBTBN in suppressing efficiency roll-off. Its remarkably fast RISC and insensitivity to doping concentration enable unprecedented versatility in advanced OLED architectures. As a sensitizer in sensitized green-fluorescent OLEDs, it surpasses Ir-based complex sensitizers in reducing efficiency roll-off. As a blue emitter in bi-color white OLEDs, it effectively harnesses high-energy triplet excitons to minimize efficiency roll-off. DBSeBN thus expands the scope of MR-TADF materials across various kinds of OLED applications while suppressing efficiency roll-off.}, archive = {J_ANGEW}, author = {Zijian Chen and Zhizhi Li and Yingrui Tian and Denghui Liu and Zhihai Yang and Mengke Li and Shi-Jian Su}, doi = {10.1002/anie.202507626}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Narrow-band dibenzoselenophene-based emitter with rapid triplet conversion for versatile OLED applications with superior roll-off suppression}, volume = {64}, year = {2025}, }
• (2025). Stable diradical-derived conjugated radical polymers. ANGEW, 64(29), e202507603. (www)

  @article{ , abstract = {Conjugated radical polymers (RPs) with polyradical structures in an π-conjugated polymeric backbone have the potential to serve as both model molecules for spin-correlated condensed matters and as materials for optoelectronics and spin-based quantum applications. However, preparing RPs of this type with high stability and spin-delocalized nature presents a significant challenge. We report herein two ambient-stable conjugated RPs ( RPH and RPC ), synthetically obtained by an unprecedented straightforward copolymerization of two brominated diradical monomers (diradical characters up to 0.88) with bis-stannylated DPP units. Compared to diradical monomers with a singlet open-shell ground state, the diradical-derived RPs gave rise to favorable spin-delocalization of conjugated polyradicals over macromolecular chain with ground states of S = 1/2, accompanied by featured electronic properties including intense near-infrared absorptions beyond 1000 nm, multi-stage amphoteric redox characteristics, and intriguing π-paramagnetism in solution and solid states. Impressively, thin-film state RPH exhibited superior ambipolar carrier-transporting properties with well-balanced hole/electron mobility of up to 0.41/0.38 cm 2 V −1 s −1 as well as attractive room-temperature quantum coherence times ( T 1 = 1.88 µs, T 2 = 218 ns), reflecting practical significance for quantum information manipulations. This study introduces a facile approach for constructing stable conjugated RPs, along with their integrated electronic and spin properties.}, archive = {J_ANGEW}, author = {Lingli Zhao and Hao Liu and Wenhao Li and Yi Yang and Xujun He and Zihong Zhang and Yan Zhao and Yifan Yao and Lei Sun and Kun Yang and Zebing Zeng}, doi = {10.1002/anie.202507603}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507603}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable diradical-derived conjugated radical polymers}, volume = {64}, year = {2025}, }
• (2025). Organophotoredox-catalyzed postfunctionalization of poly(methacrylate) derivatives via Radical–Polar crossover phosphonylation. ANGEW, 64(29), e202507572. (www)

  @article{ , abstract = {Photoredox-catalyzed postfunctionalization of poly(meth)acrylate-based copolymers bearing phthalimide moieties can produce novel polymer architectures that are inaccessible using polymerization approaches; however, this method is restricted to radical reactions. To expand the scope of reactions applicable to photoredox-catalyzed postfunctionalization, this study focused on the radical–polar crossover (RPC) process, in which a carbocation equivalent is generated to react with nucleophiles. The organophotoredox-catalyzed reaction of a random copolymer of N -(methacryloxy)phthalimide and methyl acrylate using trialkyl phosphite nucleophiles afforded the corresponding phosphonate-containing polymers. Although simultaneous hydrogenation was inevitable, a novel polymer comprising dialkyl isopropenylphosphonate, propylene, and methyl acrylate units was obtained, which is of interest because phosphonate-containing polymers are potentially applicable as thermoresponsive materials, flame-retardant materials, and additives in Li-ion batteries. A series of copolymers with different components were successfully applied to the postfunctionalization method. The organophotoredox catalysis-based postfunctionalization strategy developed in this study provides versatile functional polymers in a simple, green, and sustainable manner.}, archive = {J_ANGEW}, author = {Tomohiro Tamano and Kosuke Sato and Hirohisa Ohmiya and Shinsuke Inagi}, doi = {10.1002/anie.202507572}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organophotoredox-catalyzed postfunctionalization of poly(methacrylate) derivatives via Radical–Polar crossover phosphonylation}, volume = {64}, year = {2025}, }
• (2025). A heterodimeric cluster-based pair catalyst for electrochemical synthesis of cyclohexanone oxime. ANGEW, 64(29), e202507569. (www)

  @article{ , abstract = {Heterogeneous catalysts are complex chemical ecosystems, where various functional units execute their individual responsibilities to together complete a catalysis ensemble. Here, we report a dinuclear catalyst originated from two molecular-purity monomers including an atomically precise Ag 4 Pd 2 (SR) 8 cluster and a polyoxotitanium Ti 4 O 2 (TBC[4]) 2 ( i PrO) 4 cluster that are eventually paired off by the bridging sulfur. The heterodimeric catalyst with a unique interface consisted of the Ti─S─metal (metal = Pd and Ag) motifs exhibits selective recognition for nitrogen sources, thereby achieving high performances for the electrochemical synthesis of cyclohexanone oxime. The nitrate is favorably deoxygenated on the metal sites to generate nitrite, followed by the flipping of nitrite at the Ti─S─metal interface and the stepwise reduction of nitrite on the Ti site to produce hydroxylamine. Sequentially, a spontaneous coupling from hydroxylamine and cyclohexanone proceeds to construct the C═N bond for cyclohexanone oxime. Using this combination of distinct functional modules into one catalyst, we develop a strategy for heterogeneous catalysts being designed to increase the substrate conversion while simultaneously increasing the target product selectivity.}, archive = {J_ANGEW}, author = {Tongxin Song and Chenyang Shen and Yiqi Tian and Qingxi Zhai and Shisi Tang and Yan Zhu}, doi = {10.1002/anie.202507569}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507569}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A heterodimeric cluster-based pair catalyst for electrochemical synthesis of cyclohexanone oxime}, volume = {64}, year = {2025}, }
• (2025). Asymmetric aziridination of allylic carbamates using ion-paired rhodium complexes and extrapolation to C─H amination of phenethyl carbamates. ANGEW, 64(29), e202507532. (www)

  @article{ , abstract = {Aziridination of alkenes is an important route to chiral nitrogen-containing building blocks. Here, we report that carbamate-functionalized allylic alcohols undergo highly enantioselective aziridination using achiral dimeric Rh(II, II) complexes that are ion-paired with cinchona alkaloid-derived chiral cations. The aziridine-containing products are amenable to a variety of further reactions to generate useful groupings of functionality. Furthermore, we show that the carbamate group is effective for directing highly enantioselective benzylic C─H amination when it is appended to phenethyl alcohols. Intermolecular C─H amination of phenethyl alcohol derivatives has proven highly challenging to achieve asymmetrically yet it gives rise to valuable β-amino alcohols. Both processes result in rapid access to versatile, highly enantioenriched small molecule building blocks for synthesis and highlight the effectiveness and generality of this chiral cation-based strategy for asymmetric catalysis. We report studies that probe important structural features of the chiral cation and demonstrate that the ion-paired complexes can be formed from their individual components without a separate isolation step.}, archive = {J_ANGEW}, author = {Arthur R. Lit and Shotaro Takano and Christian Zachau and Ioana Băltărețu and Robert J. Phipps}, doi = {10.1002/anie.202507532}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507532}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric aziridination of allylic carbamates using ion-paired rhodium complexes and extrapolation to C─H amination of phenethyl carbamates}, volume = {64}, year = {2025}, }
• (2025). Asymmetric B←N functionalized benzothiadiazoles for high-performance n-type semiconducting polymers. ANGEW, 64(29), e202507528. (www)

  @article{ , abstract = {B←N containing polymers have emerged in organic electronics due to their fascinating optical and electronic properties. Despite these advantages, the development of B←N-based n-type polymers for high-performance organic transistors remains a significant challenge, primarily due to the scarcity of effective B←N containing acceptor units. In this work, we address this challenge through the rational design and synthesis of two asymmetric half-fused B←N functionalized benzothiadiazole derivatives, BTBN and FBTBN. These compounds leverage the unique electronic properties of the B←N motif, enabling the development of two new n-type polymers, PBTBN and PFBTBN. Notably, the lowest unoccupied molecular orbital (LUMO) levels of PBTBN and PFBTBN are significantly lowered by 0.2–0.3 eV compared to their counterparts without B←N functionalization, with PFBTBN achieving a LUMO of ∼ −4.0 eV. Importantly, PFBTBN exhibits exceptional unipolar n-type transistor performance with a high electron mobility ( µ e ) of 3.85 cm 2 V −1 s −1 . The asymmetric half-fused B←N molecular backbone not only stabilizes the electronic structure but also induces a near-amorphous morphology, thereby enabling PFBTBN-based flexible transistors to retain a high µ e of 3.16 cm 2 V −1 s −1 even after 1000 bending cycles. This work demonstrates the transformative potential of incorporating asymmetric B←N functionalized acceptors for high-performance n-type semiconducting polymers.}, archive = {J_ANGEW}, author = {Kewei Jiao and Wei Song and Di Liu and Zhen Jiang and Dongsheng Yan and Zhiwei Zhao and Ziyi Ge and Yunqi Liu and Yang Wang}, doi = {10.1002/anie.202507528}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507528}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric B←N functionalized benzothiadiazoles for high-performance n-type semiconducting polymers}, volume = {64}, year = {2025}, }
• (2025). Heteroanionic halogenated TiBTx MBene protective layer with dual-functional zincophilic and hydrophobic characteristics for dendrite-free zinc anode. ANGEW, 64(29), e202507504. (www)

  @article{ , abstract = {Two-dimensional (2D) hexagonal transition metal borides ( h -MBenes), emerging members of 2D materials, demonstrate significant potential as protective layers for metal anodes. However, conventional MBenes synthesized by wet etching have massive oxygen-containing terminations imported during the chemical synthesis process, with zincophobic and hydrophilic, resulting in severe dendrite growth kinetics and compromising electrode performance. In this study, we report a novel hetero-halogen TiBT X (T X = Cl and I) h -MBenes through a halogen-radius-isomerization strategy, enabling precise mixed-halogen functionalization to create an ultrahigh zincophilic and hydrophobic microenvironment. Compared to single -I terminations, the mixed-halogen TiBT X exhibits significantly enhanced zincophilicity with ordered Zn 2+ adsorption, attributed to the asymmetry-inductive effect of the larger-radius -I ions. Simultaneously, the -Cl moieties serve as a protective barrier, mitigating water-induced corrosion of the Zn anode in aqueous electrolytes. Notably, the dual-functional TiBT x -31 layer (TiBI 0.32 Cl 0.13 ) demonstrates exceptional electrochemical performance, achieving a prolonged cycling life exceeding 2000 h an impressive average coulombic efficiency of 99.86%. Furthermore, the TiBT x -31@Zn||NVO full pouch cell maintains 95.3% capacity retention over 100 cycles. This work highlights the innovative halogen-radius-isomerization approach for interfacial engineering by tailoring halogen terminations, offering new insights for the development of high-performance h -MBenes-based energy storage devices.}, archive = {J_ANGEW}, author = {Qing Shen and Jinming Wang and Zhouru He and Wangqin Fu and Edison Huixiang Ang and Junjie Wang}, doi = {10.1002/anie.202507504}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507504}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heteroanionic halogenated TiBTx MBene protective layer with dual-functional zincophilic and hydrophobic characteristics for dendrite-free zinc anode}, volume = {64}, year = {2025}, }
• (2025). Asymmetric manganese sites in covalent organic frameworks for efficient nitrate-to-ammonia electrocatalysis. ANGEW, 64(29), e202507479. (www)

  @article{ , abstract = {The electrocatalytic nitrate reduction reaction (NO 3 − RR) holds tremendous potential for remediating NO 3 − pollution while enabling clean ammonia (NH 3 ) production. However, most catalysts achieve high conversion efficiency relying on high NO 3 − concentrations. How to catalyze the NO 3 − RR with a low concentration of NO 3 − is still a challenge due to the competing hydrogen evolution reaction (HER). Herein, we constructed a novel asymmetric isolated Mn atom based on N-coordination covalent organic framework (COF) (ImPy-COF-Mn), for efficient NO 3 − RR at a low NO 3 − concentration of 2 mg mL −1 . This bidentate-coordinated COF featured a robust and chemically stable framework, while the synergistic interaction between asymmetric imine N and pyridine N modified the charge distribution of Mn atoms to optimize catalytic efficiency. ImPy-COF-Mn demonstrated remarkable catalytic performance, with 95.64% NH 3 selectivity and a maximum NH 3 yield rate of 1927 mmol h −1 g cat. −1 , exceeding the corresponding parameters of symmetric Mn sites by factors of 1.27 and 1.41, respectively. In situ ATR-FTIR measurements and theoretical calculations revealed that the asymmetric isolated Mn facilitated a reduction in the energy barrier for *NO-to-*NOH conversion, and thus contributed to higher activity and selectivity.}, archive = {J_ANGEW}, author = {Xuewen Li and Shuai Xia and Shuai Yang and Xiubei Yang and Shuang Zheng and Xiaoyu Xu and Yan Wang and Qing Xu and Zheng Jiang}, doi = {10.1002/anie.202507479}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507479}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric manganese sites in covalent organic frameworks for efficient nitrate-to-ammonia electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Defective poly(heptazine imide) nanosheets for efficient one-step two-electron photocatalytic o2 reduction to medical-like H2O2. ANGEW, 64(29), e202507415. (www)

  @article{ , abstract = {Poly(heptazine imide) (PHI) is a promising photocatalyst for hydrogen peroxide (H 2 O 2 ) production; however, enhancing its specific surface area to expose internal active sites and understanding their roles in key mechanistic steps for the H 2 O 2 synthesis remain challenging. Here, we utilized organic cations to exfoliate bulk PHI and fabricate PHI nanosheets for producing H 2 O 2 at a rate of 27.35 mmol g −1 h −1 under simulated solar light irradiation, outperforming most of the reported carbon nitride-based catalysts. Importantly, after 36 h of cyclic accumulation reactions in a self-created spiral flow reactor, the H 2 O 2 concentration stabilized at 2.7 wt.%, close to medical sterilization levels. In situ spectroscopic characterizations and density functional theory calculations revealed that the exfoliation results in molecular reconfiguration of the PHI basal planes, forming the active sites to promote charge separation and electron localization. This new structure also creates midgap states, enabling direct H 2 O 2 production via a one-step, two-electron pathway, bypassing the superoxide radical pathway. Theoretical calculations suggest that the localized electronic structure created by the active sites favors the protonation of adsorbed O 2 and stabilizes the *OOH species, which converts to H 2 O 2 . This study elucidates and underscores the importance of active-site reconfiguration for efficient photocatalytic oxygen reduction reaction (ORR) pathways.}, archive = {J_ANGEW}, author = {Laiyu Luo and Qinglong Wu and Siyu Wang and Haojie Song and Jiaqi Li and Liping Zhang and Qun Zhang and Yuanxing Fang and Baojiang Jiang and Xinchen Wang}, doi = {10.1002/anie.202507415}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507415}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Defective poly(heptazine imide) nanosheets for efficient one-step two-electron photocatalytic o2 reduction to medical-like H2O2}, volume = {64}, year = {2025}, }
• (2025). Precise construction of asymmetrically coordinated PtCuZn trimetallic atom catalysts for efficient oxygen reduction. ANGEW, 64(29), e202507395. (www)

  @article{ , abstract = {With advancements in the study of catalysts at atomic sites, the unique and predictable characteristics of atomic models have enabled the exploration of catalysts with monoatomic, diatomic, and polymetallic centers. In this study, a platinum-copper-zinc trimetallic catalyst (named PtCuZn/SNC) was synthesized by the spatial confinement method and polymer coating method. This triatomic catalyst facilitates electronic interaction and charge redistribution among the three metal atoms, optimizing the adsorption and desorption of reaction intermediates and thereby exhibiting excellent performance in acidic oxygen reduction reactions. In the oxygen reduction reaction test, a high half-wave potential of 0.859 V and an impressive energy density of 532 mW cm −2 were achieved in fuel cell tests, demonstrating the outstanding catalytic performance of the catalyst. These findings suggest that the design and synthesis of monodisperse triatomic catalysts provide a promising route to improve the efficiency of H 2 /O 2 fuel cells.}, archive = {J_ANGEW}, author = {Yuexin Guo and Zedong Zhang and Dengyu Chen and Xilin Zhang and Xiangqing Wang and Zhiyi Sun and Rui Su and Yuhai Dou and Wenxing Chen and Dingsheng Wang and Yadong Li}, doi = {10.1002/anie.202507395}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507395}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise construction of asymmetrically coordinated PtCuZn trimetallic atom catalysts for efficient oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). Ultrasound-responsive lipid nanosonosensitizers with size reduction and NO release: Synergistic sonodynamic-chemo-immunotherapy for pancreatic tumors. ANGEW, 64(29), e202507388. (www)

  @article{ , abstract = {Pancreatic cancer (PC) remains difficult to treat due to its dense extracellular matrix (ECM), immunosuppressive tumor microenvironment (TME), and deep-seated anatomy. To address these challenges, we developed IR&ZnPc@LNP-NO, an ultrasound (US)-responsive lipid nanosonosensitizer that synergizes sonodynamic therapy (SDT), chemotherapy, and immunotherapy for orthotopic PC. IR&ZnPc@LNP-NO undergoes three key US-activated responses: 1) size reduction, 2) controlled release of irinotecan (IR) and nitric oxide (NO), and 3) generation of reactive oxygen species (ROS). Under low-dose US, IR&ZnPc@LNP-NO reduces in size (from ∼120  to ∼40 nm), enhancing tumor penetration, and releases NO to remodel the TME by normalizing vasculature and degrading ECM. This enhances nanosonosensitizers accumulation and cytotoxic T cells (CTLs) infiltration. High-dose US irradiation triggers the generation of cytotoxic ROS, which, in combination with IR-mediated chemotherapy, induces immunogenic cell death (ICD) and enhances antitumor immunity. Additionally, combining IR&ZnPc@LNP-NO with PD-L1 antibody (αPD-L1) immunotherapy significantly prolongs survival in orthotopic PC models. The cascade strategy—size reduction, TME remodeling, and multimodal therapy—effectively overcomes stromal and immunosuppressive barriers, offering a robust platform for treating deep-seated PC.}, archive = {J_ANGEW}, author = {Leyi Fang and Wenhui Zeng and Yili Liu and Yinxing Miao and Chunmei Lu and Zhonghan Xu and Sensen Zhou and Qi Xue and Yitong Xu and Xiqun Jiang and Jingjuan Xu and Yan Zhang and Deju Ye}, doi = {10.1002/anie.202507388}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507388}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrasound-responsive lipid nanosonosensitizers with size reduction and NO release: Synergistic sonodynamic-chemo-immunotherapy for pancreatic tumors}, volume = {64}, year = {2025}, }
• (2025). Ammonia hydration in a Cu(II)-pyrazolate framework for efficient trace capture. ANGEW, 64(29), e202507356. (www)

  @article{ , abstract = {Ammonia (NH 3 ) emissions from industrial and agricultural activities pose severe environmental and health issues. Trace NH 3 capture typically relies on chemisorption at Lewis acid sites or physisorption on porous adsorbents but usually suffers from irreversible binding, energy-intensive regeneration, and structural degradation. In this work, for the first time, we demonstrate a new hydration pathway as a promising solution. In a Cu(II)-pyrazolate framework, BUT-64(H 2 O), the bridging water molecules between adjacent Cu(II) ions serve as Brønsted acid sites to hydrate ammonia, achieving a remarkable NH 3 packing density of 0.27 g cm −3 at 0.1 kPa and an adsorption capacity of 1.51 mmol g −1 for 1000 ppm NH 3 under 80% relative humidity, among the leading adsorbents. The reversible hydration mechanism combines enhanced NH 3 affinity with facile regeneration and mitigated moisture co-adsorption, overcoming the inherent trade-off. The remarkable alkaline stability of this material also highlights its potential as an energy-efficient sorbent for trace NH 3 capture.}, archive = {J_ANGEW}, author = {Guang-Rui Si and Xiang-Jing Kong and Tao He and Jia-Teng Zhao and Lin-Hua Xie and Jian-Rong Li}, doi = {10.1002/anie.202507356}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507356}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ammonia hydration in a Cu(II)-pyrazolate framework for efficient trace capture}, volume = {64}, year = {2025}, }
• (2025). π–π stacking as electron-transfer channels in hydrogen-bonded organic frameworks for boosting photocatalysis. ANGEW, 64(29), e202507332. (www)

  @article{ , abstract = {Photocatalysis provides a promising approach to produce green energy, by which the intermittent solar energy can be converted into storable chemical energy. It is well-known that the electron-transfer rate has great influence on the photocatalytic efficiency. Revealing the influence of electron-transfer rate on the photocatalytic efficiency from a molecular level is of great significance but a challenge. Herein, we give solid evidence to show that the π–π stacking can serve as an electron-transfer channel to boost photocatalysis. Specifically, two hydrogen-bonded organic frameworks (HOFs) with similar structures but slightly different intermolecular interactions have been weaved. Interestingly, the HOF with π–π stacking interactions shows much higher photocatalytic activity for hydrogen evolution than the one without. Further structural and spectroscopic analyses revealed that the much-enhanced photocatalytic activity of the former can be attributed to the π–π stacking, which can really serve as an electron-transfer channel, thus accelerating the electron transfer and achieving a remarkably enhanced activity in photocatalytic hydrogen evolution. The work, from a molecular level, reveals the role of π–π stacking in photocatalysis and gives new insights into the electron-transfer in photocatalysts.}, archive = {J_ANGEW}, author = {Jian-Hua Mei and Ya-Ru Zeng and Yun-Nan Gong and Wen-Jie Shi and Di-Chang Zhong and Tong-Bu Lu}, doi = {10.1002/anie.202507332}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507332}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π–π stacking as electron-transfer channels in hydrogen-bonded organic frameworks for boosting photocatalysis}, volume = {64}, year = {2025}, }
• (2025). From amino acids to α-keto acids via β-elimination and transamination initiates a pathway to prebiotic reaction networks. ANGEW, 64(29), e202507248. (www)

  @article{ , abstract = {α-Keto acids, such as pyruvate and glyoxylate, may have been critical in generating reaction networks at the origins of life due to their facile carbon–carbon bond formation and their hydrolytic stability. However, demonstrated prebiotic sources of these small α-keto acids have been limited by conditions required for their production, which are not conducive for subsequent incorporation or transition into (proto)metabolic pathways. Here, we demonstrate an abiotic generation of α-keto acids from only two amino acids, starting with the phosphorylation and dehydration of serine (Ser) coupled with a transamination with glycine (Gly), to produce both pyruvate and glyoxylate. This triggers an in situ reaction pathway producing higher-order α-keto acids, including amino acid precursors found in modern biology. These findings may help elucidate how protometabolic chemical networks can emerge on the early Earth under mild aqueous conditions, leading to a coupled amino acid—α-keto acid chemical system capable of supporting a more robust metabolism.}, archive = {J_ANGEW}, author = {Louis M.P. Ter-Ovanessian and Kate L. Ryan and Joshua Shaarda and R. Trent Stubbs and Ramanarayanan Krishnamurthy and Greg Springsteen}, doi = {10.1002/anie.202507248}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507248}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From amino acids to α-keto acids via β-elimination and transamination initiates a pathway to prebiotic reaction networks}, volume = {64}, year = {2025}, }
• (2025). Decavanadate-catalyzed oxidative cross-dehydrogenative coupling: An efficient and sustainable approach toward P(O)─S bond formation. ANGEW, 64(29), e202507245. (www)

  @article{ , abstract = {A convenient green protocol has been developed for the cross-dehydrogenative coupling between thiols and P(O)−H compounds using decavanadate anion as the catalyst at room temperature under open-flask conditions. The reaction proceeds efficiently in water or ethanol without any assistance of heat, light, electricity, or unfriendly additives and tolerates a broad spectrum of functional groups, delivering the desired products in up to 95% yield. Importantly, the decavanadate catalyst can be easily recycled in gram-scale synthesis at least six times without a significant decline in reaction yield. Further, mechanistic investigations evidence the formation of tetravalent vanadium-hydroxo-species in the reaction process and reveal that the P(O)−S dehydrogenative coupling is enabled via a V V to V IV catalytic cycle.}, archive = {J_ANGEW}, author = {Jian Lei and Zhenliang Yu and Shi Ru and Zixiu Wang and Shan Li and Nianhua Luo and Jiuzhong Huang and Xiaopeng Peng and Feng Jiang and Yongge Wei}, doi = {10.1002/anie.202507245}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507245}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decavanadate-catalyzed oxidative cross-dehydrogenative coupling: An efficient and sustainable approach toward P(O)─S bond formation}, volume = {64}, year = {2025}, }
• (2025). Constructing matching interfaces by amorphous engineering for enhanced lithium ion transport in quasi-solid-state Lithium–Iodine batteries. ANGEW, 64(29), e202507184. (www)

  @article{ , abstract = {Quasi-solid-state lithium–iodine (Li–I 2 ) batteries have shown prospects as their high theoretical capacity, high safety, and abundant iodine resources. However, the interface between the crystalline filler and the flexible polymer skeleton of composite solid electrolytes exhibits inadequate bonding, leading to higher interface energy and sluggish migration dynamics of Li + . In this work, a continuous interface solid electrolyte is designed by combining the atomic structure rearrangement of metal-organic framework (MOF) to achieve interface coupling between MOF and aramid fiber. Based on the experimental results and theoretical calculations, the amorphous engineering promotes Li + migration and polyiodide confinement effects for Li–I 2 batteries. The batteries show a high capacity of 170.7 mAh g −1 at 5 C and achieve a capacity retention rate of 97.8% after 450 cycles. More impressively, the batteries achieve a long life of 3000 cycles at the high current density of 20 C with a good capacity retention of 94.1%. This work reveals the mechanism of coupled interface with structure matching in Li + migration and polyiodide integration process, providing guidance for the design of novel composite solid electrolytes to achieve high-performance Li–I 2 batteries.}, archive = {J_ANGEW}, author = {Jiapei Gu and Chenxu Dong and Yuxin Zhu and Haoyun Liu and Juan Ji and Yongkun Yu and Changning Ma and Cheng Zhou and Liqiang Mai and Xu Xu}, doi = {10.1002/anie.202507184}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507184}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing matching interfaces by amorphous engineering for enhanced lithium ion transport in quasi-solid-state Lithium–Iodine batteries}, volume = {64}, year = {2025}, }
• (2025). Harnessing porous coordination cages for sonodynamic therapy: Enhanced efficacy through atomic precision and immune activation. ANGEW, 64(29), e202507180. (www)

  @article{ , abstract = {Sonodynamic therapy (SDT) has emerged as a promising non-invasive approach for immunotherapy. However, its broad applicability is often limited by the inefficiency of sonosensitizers. Here, we introduce a novel series of porous coordination cages (PCCs) specifically engineered to enhance sonodynamic therapeutic performance for the first time. These PCCs incorporate energy harvesting and conversion components, with variations in bandgap, electrical conductivity, and redox activity. Characterized by atomically precise compositions and well-defined structures, the PCCs enable strategic manipulation of functionalized moieties and metal centers, allowing for precise control over their sonodynamic efficiency. Their small particle size enhances penetration through dense tumor extracellular matrices, significantly improving tumor permeability. Upon ultrasound stimulation, the PCCs exhibit robust sonodynamic effects, resulting in increased reactive oxygen species (ROS) levels in tumor cells, which triggers apoptosis and antigens release. Notably, PCC-1 demonstrates metal-mediated catalytic activity, converting endogenous hydrogen peroxide into additional ROS, synergistically enhancing SDT efficacy and activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway in dendritic cells. In tumor model, PCCs effectively inhibited tumor growth and activated immune responses both locally and systemically. Collectively, these findings underscore the exceptional sonodynamic-immunotherapeutic potential of PCCs, paving the way for innovative strategies in tumor treatment.}, archive = {J_ANGEW}, author = {Yong Tan and Huihui He and Baoli Yin and Dingyou Lu and Jinyu Li and Hengxin Shen and Xiao-Bing Zhang and Yu Fang and Guosheng Song}, doi = {10.1002/anie.202507180}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507180}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing porous coordination cages for sonodynamic therapy: Enhanced efficacy through atomic precision and immune activation}, volume = {64}, year = {2025}, }
• (2025). High-entropy modulated high-spin localized cobalt sites enhance catalytic ozonation for efficient odor control. ANGEW, 64(29), e202507109. (www)

  @article{ , abstract = {Catalytic ozonation technology is crucial for environmental remediation due to its exceptional efficiency and capability for complete mineralization of organic pollutants. However, hindered by spin-forbidden transitions, effective catalytic ozonation remains contingent upon the electronic properties and interfacial interactions of the catalyst. Recent studies identify interfacial atomic metal-oxygen species (*O) as a key descriptor in catalytic ozonation, determining the derivation of reactive species and subsEquationuent reactivity. Herein, we modulated the high-spin localized Co active sites in HE-Co 3 O 4 via a high-entropy strategy, which selectively stabilizes *O surface species, thereby enhancing catalytic ozonation efficiency. HE-Co 3 O 4 exhibits a five-fold higher degradation rate than Co 3 O 4 for 50 ppm CH 3 SH elimination (63-fold the mass activity compared to commercial MnO 2 ) while maintaining exceptional stability over 24 h at 298 K. Electron paramagnetic resonance (EPR) and magnetization hysteresis (M-H) measurements confirm the transition of Co 3+ to high-spin states in HE-Co 3 O 4 . Density functional theory (DFT) calculations reveal that unpaired electrons enhance the hybridization of Co 3d with O 2p orbitals, thereby establishing a *O-mediated interfacial pathway. This mechanism is directly observed through in situ Raman spectroscopy. These findings provide insights into the targeted modulation of catalyst electronic structures for ozone-catalyzed environmental remediation.}, archive = {J_ANGEW}, author = {Rumeng Zhang and Hao Zhou and Tao Shao and Qiyu Lian and Mengliang Hu and Ji Mei and Shulin Zuo and Jiahao Huang and Zhuoyun Tang and Dehua Xia}, doi = {10.1002/anie.202507109}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507109}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy modulated high-spin localized cobalt sites enhance catalytic ozonation for efficient odor control}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed cross-electrophile coupling to access polysubstituted cyclobutenes. ANGEW, 64(29), e202507087. (www)

  @article{ , abstract = {The synthesis of cyclobutenes remains inefficient owing to inherent ring strain and poor regioselectivity. We describe herein a nickel-catalyzed cross-electrophile coupling (XEC) between readily accessible homopropargyl halides and commercially available aryl/vinyl electrophiles for direct access to polysubstituted cyclobutenes. This approach provides the first reductive 4 -endo-dig cyclization with high chemo- and regioselectivity, which paves the way for the synthesis of diverse cyclobutene containing compounds (including synthetically challenging macrocycles). The synthesis of an antitumor-active combretastatin A-4 analog has been significantly optimized; the original six-step procedure yielding 14% has been streamlined into a three-step process with a markedly improved yield of 51%. Experimental data and computational studies support a mechanism involving an alkenyl nickel(I) intermediate, which undergoes facile back-side S H 2 attack to produce the strained cyclobutene ring with overall stereoinversion at the homopropargylic position.}, archive = {J_ANGEW}, author = {Zining Liu and Yandong Wang and Jiahui Yu and Huanfeng Jiang and Minyan Wang and Liangbin Huang}, doi = {10.1002/anie.202507087}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507087}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed cross-electrophile coupling to access polysubstituted cyclobutenes}, volume = {64}, year = {2025}, }
• (2025). Transient supramolecular polymers by pH-gated conformational control of a self-assembling cyclodextrin. ANGEW, 64(29), e202507069. (www)

  @article{ , abstract = {Linking a cyclodextrin (CD) host to a hydrophobic guest can result in two distinct conformations: an introverted form ( in ), in which the guest is self-included within the CD cavity, and an extraverted form ( out ), which enables intermolecular interactions and thus the formation of a supramolecular polymer. In this study, we demonstrate that a subtle variation of the linker enables interconversion between these two conformations, the in conformer being thermodynamically the most stable in water. At basic pH (>8) the out conformer is instantly converted into the in . In contrast, at acidic pH (<2), the out monomer can be kinetically trapped and can self-assemble into a supramolecular polymer. DFT calculations reveal that the interconversion mechanism is governed by a key hydrogen bond that locks the conformational states. Furthermore, we show that pH provides fine kinetic control over the interconversion rate and, consequently, the polymerization process. The system can then be reset toward the out conformation by using DMSO. This system stands in contrast to known transient supramolecular polymerization processes, which rely on metastable (non-assembled) monomers. Here, it is the kinetic trapping of the assembling monomer that allows control over the lifetime of the transient supramolecular polymer via a pH-responsive mechanism.}, archive = {J_ANGEW}, author = {Wenting Hu and Valérian Libérioux and Julien Rossignol and Gaëlle Pembouong and Etienne Derat and Mickaël Ménand and Laurent Bouteiller and Matthieu Sollogoub}, doi = {10.1002/anie.202507069}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transient supramolecular polymers by pH-gated conformational control of a self-assembling cyclodextrin}, volume = {64}, year = {2025}, }
• (2025). Molecular engineering of weakly solvating dinitrile electrolytes for long-lasting room-temperature lithium metal batteries. ANGEW, 64(29), e202507051. (www)

  @article{ , abstract = {The development of lithium metal batteries (LMBs) relies on advanced solid-state electrolytes. Solid-state polymer electrolytes (SPEs) offer advantages such as cost-effectiveness, mechanical flexibility, and light weight; however, their practical use is hindered by limited ionic conductivity, narrow electrochemical stability window, and suboptimal cycling performance. Herein, we present a class of weakly-solvating dinitrile-based SPEs (DBSPEs) composed of a poly(2-(2-(2-methoxyethoxy)ethoxy)ethyl acrylate) network coupled with structurally modulated dinitrile solvents. Through rationale molecular engineering, the synergistic combination of short ethylene oxide side chains and weakly coordinating dinitrile solvents enables weak hybrid solvation of lithium ions, thereby facilitating rapid ion migration and uniform lithium deposition. The optimized DBSPE-2 exhibits a high ionic conductivity (∼2.2 × 10 −3 S cm −1 ) and an extremely wide electrochemical window (∼5.7 V). Notably, the Li||DBSPE-2||Li symmetric cell yields stable lithium plating/stripping over 6900 h at 0.1 mA cm⁻ 2 under ambient conditions (26 °C). When paired with LiFePO₄ in a full cell, the LMBs deliver a superior fast-charging capability, realizing 80.78% capacity retention after 1500 cycles at 2.0 C rate. This work provides fundamental insights into the solvation structure and accordingly realizes long-lasting LMBs with weak solvents.}, archive = {J_ANGEW}, author = {Chuan Luo and Chunpeng Ning and Xuehai Huang and Panjing Zhang and Liwei Yang and Sijing Wang and Junchen Wang and Yu Wang and Kai Wan and Zi-Hao Guo and Kan Yue and Zhenxing Liang}, doi = {10.1002/anie.202507051}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507051}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular engineering of weakly solvating dinitrile electrolytes for long-lasting room-temperature lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Electrochemical benzylic C─H sulfation beyond the O-sulfonation limitation. ANGEW, 64(29), e202507048. (www)

  @article{ , abstract = {Direct C─H sulfation represents a valuable transformation for the synthesis of organosulfates. However, it has been challenging to achieve owing to the presence of multiple C─H bonds with comparable strengths and steric environments. Current methods for producing organosulfates primarily rely on O -sulfonation, which limits their applicability to hydroxyl-containing compounds. Herein, we report a practical and cost-efficient method for the electrochemical sulfation of benzylic C─H bonds. This reaction avoids the need for strong oxidants, demonstrating broad substrate scope, excellent chemoselectivity, and site selectivity. The orthogonal reactivity of this protocol is particularly evident in the transformation of alcohol substrates.}, archive = {J_ANGEW}, author = {Wei Sheng and Huanhuan Peng and Ben Gao and Chunlan Song and Jiakun Li}, doi = {10.1002/anie.202507048}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507048}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical benzylic C─H sulfation beyond the O-sulfonation limitation}, volume = {64}, year = {2025}, }
• (2025). One-dimensional covalent organic frameworks: From design, synthesis to applications. ANGEW, 64(29), e202507002. (www)

  @article{ , abstract = {As an important branch of the covalent organic frameworks (COFs) family, one-dimensional COFs (1D COFs), which are formed by the ordered arrangement of confined covalent bonds in one dimension and non-covalent interactions (van der Waals force, π–π interactions, and hydrogen bonds) in the vertical two and three dimensions has aroused much attention. Compared with two-dimensional (2D)/three-dimensional (3D) COFs, 1D COFs behaved more easily dispersing and had more opportunities for active sites exposure due to their weaker interchain/interlayer interaction, modified nonlinear edge, and pore structures. These features make them have great application potential in many fields, including catalysis, energy storage, adsorption, sensing, and others. In this minireview, we highlight the state-of-the-art advances of 1D COFs in the structure design principles of building blocks, synthesis strategies, and their related applications. Furthermore, we present an in-depth outlook on the challenges and opportunities faced by 1D COFs, aiming to offer insights for future studies in this intriguing and significant research field.}, archive = {J_ANGEW}, author = {Pei Huang and Lu-Hua Hou and Ming-Yi Yang and Cheng Xiao and Yan-Li Wu and Si-Jing Cai and Wen-Jie Guo and Mi Zhang and Meng Lu and Ya-Qian Lan}, doi = {10.1002/anie.202507002}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202507002}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-dimensional covalent organic frameworks: From design, synthesis to applications}, volume = {64}, year = {2025}, }
• (2025). Molecular ordering in low-dimensional hybrid perovskites for improved X-ray detection. ANGEW, 64(29), e202506973. (www)

  @article{ , abstract = {Low-dimensional hybrid perovskites are emerging semiconductors with excellent photophysical property, chemical stability, and structural diversity and have shown prominence in the fields of solar cells, light-emitting diodes, and X-ray detectors. To date, the inorganic framework structure in perovskites has been intensively studied, but the molecular arrangement of organic counterparts and its impact on physical properties remains largely unexplored. Herein, we engineer the coordination geometry of inorganic and organic building units to implement molecular ordering and π–π stacking in low-dimensional perovskites. We observe a positive dependence of carrier transport capacity and environmental stability on the molecular regularity in hybrid perovskites. Furthermore, 5-aminoquinoline lead iodide single crystal with the highest regularity exhibit nearly 5-fold increased carrier mobility-lifetime product and 20-fold decreased ionic conductivity along [011] than [100] orientation, enabling a high sensitivity of 8.25 × 10 5 µC Gy air −1 cm −2 under 8 keV X-ray radiation for radiation detection application. This work sheds light on the design and synthesis of next-generation perovskite-based semiconductors with enhanced performance and stability for optoelectronic applications.}, archive = {J_ANGEW}, author = {Sihan Zeng and Xinyuan Sui and Da Liu and Yu Peng and Qing Li and Mengyao Song and Junjie Qian and Haiyang Yuan and Shuang Yang and Hua Gui Yang and Yu Hou}, doi = {10.1002/anie.202506973}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular ordering in low-dimensional hybrid perovskites for improved X-ray detection}, volume = {64}, year = {2025}, }
• (2025). Catalyst-free dynamic covalent Knoevenagel/Hydrazide condensation for polyacylhydrazones and covalent adaptable networks. ANGEW, 64(29), e202506939. (www)

  @article{ , abstract = {The rapid advancement of dynamic covalent chemistry (DCvC) has significantly impacted both chemistry and materials science. There is an increasing need for exploring catalyst-free dynamic covalent reactions with large equilibrium constant ( K eq ) ranges to provide new avenues for the tailored design of dynamic polymers. Here, we report a catalyst-free dynamic covalent condensation reaction between Knoevenagel derivatives (Kn) and hydrazides to generate acylhydrazones. Systematic small-molecule studies validate a significant substituent effect on the Kn reactant, resulting in a wide K eq range covering nearly four orders of magnitude (0.1–719). The high K eq values (>500) achieved in polar aprotic solvents enable the catalyst-free synthesis of high-molar-mass (−180 kDa) polyacylhydrazones. The retention of by-products during polycondensation leads to concentration-dependent topology switching between polymeric and macrocyclic acylhydrazones. By leveraging this reaction, we developed a novel covalent adaptable network (CAN) that exhibits remarkable stress relaxation properties (38 s at 160 °C), facilitating efficient thermal reprocessing while maintaining high mechanical performance. This condensation reaction enriches the dynamic covalent toolbox and offers a versatile approach for the design and fabrication of dynamic polymers with tailored mechanical and dynamic behavior.}, archive = {J_ANGEW}, author = {Pengyun Li and Jingwen Zhang and Zhiqiang Wang and Chong Li and Huiping Wu and Mengying Lei and Ge Yan and He Tian and Ruirui Gu and Da-Hui Qu}, doi = {10.1002/anie.202506939}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506939}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalyst-free dynamic covalent Knoevenagel/Hydrazide condensation for polyacylhydrazones and covalent adaptable networks}, volume = {64}, year = {2025}, }
• (2025). Phase engineering for achieving full-color tunable emission from blue to red and multi-level information security in isomeric hybrid copper halides. ANGEW, 64(29), e202506748. (www)

  @article{ , abstract = {The design and synthesis of novel hybrid metal halides polymorphs with full-color tunable emission are critical for the advancement of solid-state lighting and display technologies. However, it remains challenging and rarely reported. Herein, we successfully synthesized three new zero-dimensional (0D) hybrid isomeric copper (I) halides, namely α-/β-/γ-(BuPh 3 P) 2 Cu 2 I 4 (where BuPh 3 P + = butyltriphenylphosphonium, C 22 H 24 P + ), featuring the same edge-sharing [Cu 2 I 4 ] 2− units. Notably, the monoclinic α-(BuPh 3 P) 2 Cu 2 I 4 and β-(BuPh 3 P) 2 Cu 2 I 4 , both belonging to the P 2 1 / n space group, exhibit bright blue and orange emission, respectively. The orthorhombic-phase γ-(BuPh 3 P) 2 Cu 2 I 4 with space group Pbca and larger lattice volume shows vivid red emission, thus achieving tunable full-color emission wavelength spanning from blue (445 nm) to red (667 nm), representing the first instance of such broad tunability through adjusting the spatial arrangement of the organic and inorganic parts. Interestingly, α-(BuPh 3 P) 2 Cu 2 I 4 undergoes a reversible photo-induced fluorochromism, transitioning from blue to green. Furthermore, a reversible phase transformation between α- and β-(BuPh 3 P) 2 Cu 2 I 4 can be triggered by dichloromethane and ethyl acetate. As such, a photo-responsive switchable system and a multistage information encryption/decryption system are successfully devised through leveraging unique multi-stimuli-responsive properties.}, archive = {J_ANGEW}, author = {Jiajing Wu and Qiao-Feng Huang and Yi-Fan Fu and Jing-Li Qi and Li-Xiang Chen and Shu-Fang Yan and Wenlong Liu and Sheng-Ping Guo}, doi = {10.1002/anie.202506748}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506748}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phase engineering for achieving full-color tunable emission from blue to red and multi-level information security in isomeric hybrid copper halides}, volume = {64}, year = {2025}, }
• (2025). An all-in-one nanohole array for size-exclusive trapping and high-throughput digital counting of single extracellular vesicles for non-invasive cancer screening. ANGEW, 64(29), e202506744. (www)

  @article{ , abstract = {The analysis of single small extracellular vesicles (sEVs) could distinguish the heterogeneity of sEVs thus better extract tumor-related signatures. Current protocols for the analysis of single sEV rely mainly on the advanced techniques and require lengthy isolation procedures, limiting applications in clinical diagnosis. Herein, we developed a one-step procedure for rapid isolation of single sEVs from urine, along with an analytical pipeline for the diagnosis of early bladder cancer (BCa). Single sEVs are isolated by an EV-imprinted gold nanohole (EI-AuNH) array that selectively traps individual sEVs and spatially enhances their Raman spectra. After the invalid spectral data from incomplete or absent sEVs was eliminated using Smart-Filter, a convolutional neural network model identifies the origin of the spectra and generates a digital count matrix for each patient. By integrating the digital count data of both tumor-associated and normal sEVs, our model achieves an accuracy of 97.37% in early diagnosis of BCa. Feature extraction using explainable AI identified nine BCa-related signatures, with noticeable reduction on cholesterol and lipids in BCa-associated sEVs. These signatures could further distinguish BCa from other cancers. Overall, the present non-invasive and highly accurate diagnosis platform may revolutionize clinical disease diagnostics through simplified single sEV isolation and advanced modeling.}, archive = {J_ANGEW}, author = {Lilin Yin and Xianyao Han and Fulin Guo and Yuning Zou and Qingpeng Xie and Jianhua Wang and Chaoyong Yang and Ting Yang}, doi = {10.1002/anie.202506744}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An all-in-one nanohole array for size-exclusive trapping and high-throughput digital counting of single extracellular vesicles for non-invasive cancer screening}, volume = {64}, year = {2025}, }
• (2025). Single-crystal-to-single-crystal synthesis of a rope-ladder polymer. ANGEW, 64(29), e202506699. (www)

  @article{ , abstract = {Here, we report a single-crystal-to-single-crystal (SCSC) synthesis of a fully organic ladder polymer via a topochemical azide-alkyne cycloaddition (TAAC) reaction. A designed monomer featuring a rigid benzene core with flexible peptide-linked azide and alkyne groups crystallized with three conformers in the asymmetric unit, as evidenced by the single-crystal X-ray diffraction (SCXRD) analysis. Hydrogen bonding between the amino acid residues facilitates the organization of the monomer in a reactive geometry with inter-conformer azide-alkyne end-to-end distances within Schmidt's criteria. Upon thermal activation, two of the three monomer-conformers reacted to form a dimer, leading to an intermediate 1:1 cocrystal of monomer and dimer. The intermediate cocrystal reacted further, forming a structurally perfect ladder polymer in an SCSC manner. SCXRD analysis confirmed the regiospecificity of the reaction yielding 1,5-triazolyl linkages in both the intermediate dimer and the polymer. The polymerization process was also studied by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FT-IR). This study demonstrates the scope of topochemical polymerization strategies to synthesize architecturally attractive crystalline polymers that enable precise structural elucidation.}, archive = {J_ANGEW}, author = {Haripriya Balan and Gopika Sadasivan and Elizabeth Paul and Kana M. Sureshan}, doi = {10.1002/anie.202506699}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506699}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-crystal-to-single-crystal synthesis of a rope-ladder polymer}, volume = {64}, year = {2025}, }
• (2025). Thermally gated covalent adaptivity in liquid crystal elastomers for stable actuation. ANGEW, 64(29), e202506571. (www)

  @article{ , abstract = {Liquid crystal elastomers (LCEs), with reversible actuation of large and anisotropic deformation, have surged in smart materials such as soft robotics, sensors and artificial muscles. LCEs incorporating dynamic covalent bonds (DCBs) endowing network with rearranging ability through reversible bond exchange, facilitating the fabrication of soft actuators with tailored actuation modes and reprogrammability. However, unintended activation of DCBs during actuation, particularly under thermal perturbations, remains a critical challenge, as it damages actuation stability which arises catastrophic failure and potential security risks in practical applications. Present strategies in enhancing actuation stability either achieve only transient stability or sacrificed reprogrammability or actuation performance. Here, we propose a strategy incorporating catalyst-free α-AC/A DCB of high temperature active-threshold to fabricate stable exchangeable LCE actuators with thermally gated behavior. This design exhibits a “thermal gate” at 120 °C with inert bond exchange below this threshold, yet rapidly activated at 160 °C. The integrated permanent crosslinks further prevent unintended chain slippage, ensuring topological stability. The resulting exchangeable LCE could be fabricated to actuators efficiently and exhibiting unprecedented durability at 120 °C (sustaining 10 000 actuation cycles). The switch between reprogrammability and actuation stability are long-standing reversible, meeting the demands of long-term service without compromising its reprogrammability.}, archive = {J_ANGEW}, author = {Yixuan Wang and Enjian He and Huan Liang and Yuting Wang and Zhijun Yang and Shuhan Zhang and Yen Wei and Guoli Wang and Chao Gao and Yan Ji}, doi = {10.1002/anie.202506571}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermally gated covalent adaptivity in liquid crystal elastomers for stable actuation}, volume = {64}, year = {2025}, }
• (2025). Integrating urea-based units into porphyrinic covalent organic framework for efficient artemisinin photosynthesis. ANGEW, 64(29), e202506462. (www)

  @article{ , abstract = {Artemisinin and its derivatives are the most efficacious treatment for malaria, and the artificial synthesis of artemisinin supplies a promising method to satisfy market demand. However, conventional artemisinin preparation via homogeneous photo/acid-catalytic reactions usually suffers from the difficulty in recycling the photo/acid-catalysts and treating waste acid. Consequently, it is still highly urgent for developing environment-friendly and effective artificial preparation methods for artemisinin. Herein, a dual-function covalent organic framework (COF), named Urea-COF, has been synthesized from the condensation of meso-tetra(p-formylphenyl)porphyrin with 1,3-bis(4-aminophenyl)urea. UreaCOF exhibits a high surface area of 1732 m 2 g −1 with a large pore size of 3.1 nm, enabling a fast mass transport and high accessibility of urea groups. The urea groups as hydrogen bond donor catalytic sites bind strongly to the carboxylic acid to release H + , thereby increasing the acidity of the carboxylic acid. This, in combination with the exceptional capacity of porphyrin macrocycles to generate singlet oxygen, endows Urea-COF with excellent heterogeneous photocatalytic activity toward tandem semisynthesis of artemisinin from dihydroartemisinic acid in a high conversion rate (99%) and yield (71%) without additional acid, superior to all the thus far reported homogeneous and heterogeneous photocatalytic systems.}, archive = {J_ANGEW}, author = {Wenbo Liu and Zhixin Liu and Lei Gong and Kang Wang and Biao Wu and Jianzhuang Jiang}, doi = {10.1002/anie.202506462}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506462}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating urea-based units into porphyrinic covalent organic framework for efficient artemisinin photosynthesis}, volume = {64}, year = {2025}, }
• (2025). A nonfused ring electron acceptor with aggregation-induced emission assistance achieving over 20% efficiency in organic solar cells. ANGEW, 64(29), e202506415. (www)

  @article{ , abstract = {The development of nonfused ring electron acceptors (NFREAs) with high electroluminescence quantum efficiency (EQE EL ) is essential for advancing the commercialization of organic solar cells (OSCs), due to their low-cost and minimal energy losses ( E loss ). However, designing such NFREAs remains a significant challenge. Herein, we present a medium-bandgap NFREA, TT-TCBr, which exhibits a high EQE EL of 1.0 × 10 −3 and an excellent electron mobility of 1.5 × 10 −4 cm 2 V −1 s −1 . Interestingly, TT-TCBr shows enhanced photoluminescence quantum yield from solution (9.24%) to film (20.7%). In OSCs, the D18:TT-TCBr-based OSC achieves a good power conversion efficiency (PCE) of 13.20% with a high open-circuit voltage of 1.09 V and a low nonradiative energy loss of 0.177 eV. Importantly, TT-TCBr shows good miscibility with L8-BO, leading to an increased exciton diffusion length and EQE EL in the L8-BO: TT-TCBr blend. When TT-TCBr is introduced as a guest molecule into the D18:L8-BO-based OSC, E loss is reduced from 0.543 to 0.530 eV, resulting in a significantly increased PCE from 19.16% to 20.10%, which represents one of the highest PCEs reported for OSCs. This research will significantly contribute to the advancement of high-performance guest materials for the rapid development of single-junction OSCs.}, archive = {J_ANGEW}, author = {Kun Li and Qian Xie and Cunbin An and Jianbin Zhong and Yuan Yao and Chuangcheng Hong and Yu Chen and Hua Geng and Yishi Wu and Wei Zhang and Qing Liao and Hongbing Fu}, doi = {10.1002/anie.202506415}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506415}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A nonfused ring electron acceptor with aggregation-induced emission assistance achieving over 20% efficiency in organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Cooperative photometallobiocatalysis: Nonheme fe enzyme-catalyzed enantioconvergent radical decarboxylative azidation, thiocyanation, and isocyanation of redox-active esters. ANGEW, 64(29), e202506361. (www)

  @article{ , abstract = {Cooperative catalysis with an enzyme and a small-molecule photocatalyst has recently emerged as a potentially general activation mode to advance novel biocatalytic reactions with synthetic utility. Herein, we report cooperative photobiocatalysis involving an engineered nonheme Fe enzyme and a tailored photoredox catalyst to achieve enantioconvergent decarboxylative azidation, thiocyanation, and isocyanation of redox-active esters via a radical mechanism. We repurposed and further evolved metapyrocatechase (MPC), a nonheme Fe extradiol dioxygenase not previously studied in new-to-nature biocatalysis, for the enantioselective C─N 3 , C─SCN, and C─NCO bond formation via an enzymatic Fe─X intermediate (X═N 3 , NCS, and NCO). A range of primary, secondary, and tertiary alkyl radical precursors were effectively converted by our engineered MPC, allowing the syntheses of organic azides, thiocyanates, and isocyanates with good to excellent enantiocontrol. Further derivatization of these products furnished valuable compounds including enantioenriched amines, triazoles, ureas, and SCF 3 -containing products. DFT and MD simulations shed light on the mechanism as well as the binding poses of the alkyl radical intermediate in the enzyme active site and the π-facial selectivity in the enantiodetermining radical rebound. Overall, cooperative photometallobiocatalysis with nonheme Fe enzymes provides a means to develop challenging asymmetric radical transformations eluding small-molecule catalysis.}, archive = {J_ANGEW}, author = {Liu-Peng Zhao and Ken Lin and Pei-Pei Xie and Huichong Liu and Hengye Xiang and Xin Liu and Yunlong Zhao and Peng Liu and Yang Yang}, doi = {10.1002/anie.202506361}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506361}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative photometallobiocatalysis: Nonheme fe enzyme-catalyzed enantioconvergent radical decarboxylative azidation, thiocyanation, and isocyanation of redox-active esters}, volume = {64}, year = {2025}, }
• (2025). Helicenes with four helical turns: Dimerization of [13]Helicenes to [27]Helicenoids. ANGEW, 64(29), e202506328. (www)

  @article{ , abstract = {The promise of enhanced circularly polarized luminescence (CPL) from organic molecules has inspired synthetic efforts to prepare elongated multi-layer helicenes. It has proven particularly challenging to synthesize and isolate enantiomerically pure multi-turn helicenes, and consequently, clear guidelines for the molecular design of helicenes to achieve large CPL output remain elusive. We explore the oxidative dimerization of a 2-naphthol-annulated hetero[13]helicene, and observe the formation of two types of structurally distinct hetero[27]helicenes, both with four helical turns, form. With Cu II Cl(OH)-TMEDA as the oxidant, a symmetric dimer ( bi[13] ) formed, joining two helicenes with the same helicity in their keto tautomeric forms. Using Cu II (OTf)₂ as the oxidant led to an unsymmetrical [27]helicenoid composed by an ( M )- and a ( P )-enantiomer of the [13]helicene through an unusual coupling between the 1- and 3-positions of the 2-naphthol units. Structural characterization was achieved by NMR spectroscopy and single-crystal (X-ray or electron) diffraction analysis. The enantiomers of this [27]helicenoid were analyzed by electronic circular dichroism (ECD) and CPL measurements. The spectroscopic data were corroborated by DFT calculations, and the intense CPL output is preserved despite the presence of an ( M )- and a ( P ) -helicene in the same molecule. These [27]helicenoids are the first isolated structures that feature helical π-systems with four helical turns.}, archive = {J_ANGEW}, author = {Matea Sršen and Stephan K. Pedersen and Tomislav Rožić and Arianna Lanza and Michael Pittelkow}, doi = {10.1002/anie.202506328}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506328}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Helicenes with four helical turns: Dimerization of [13]Helicenes to [27]Helicenoids}, volume = {64}, year = {2025}, }
• (2025). Imidazo[1,5-a]pyridines – A versatile platform for structurally distinct N-heterocyclic olefins and π-extended heterocycles. ANGEW, 64(29), e202506305. (www)

  @article{ , abstract = {The synthesis of polarized N -heterocyclic olefins (NHOs) based on an imidazo[1,5- a ]pyridine scaffold is presented. In contrast to regular NHOs the unique bicyclic heterocyclic core allows the incorporation of various substituents in close proximity to the highly polarized exocyclic C─C bond. The donor properties of the new carbon-based ligand class were quantified and the coordination chemistry explored. Alkenyl or alkynyl groups at the C5-position lead to spontaneous cyclization to yield imidazo[2,1,5- de ]quinolizines. The unique cyclization strategy was compatible with a wide range of substitution patterns and yields highly electron-rich π-delocalized heterocycles. The electronic structure of the novel partially antiaromatic heterocycle was thoroughly investigated. One-electron oxidation occurs at low potentials and lead to a stable monomeric radical-cation confirmed by XRD, which showed solution phase fluorescence expanding into the field of open-shell organic materials.}, archive = {J_ANGEW}, author = {Robin Esken and Patrick W. Antoni and Yannick Lorenz and Chris Burdenski and Jan-Lukas Kirchhoff and Carsten Strohmann and Max M. Hansmann}, doi = {10.1002/anie.202506305}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506305}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imidazo[1,5-a]pyridines – A versatile platform for structurally distinct N-heterocyclic olefins and π-extended heterocycles}, volume = {64}, year = {2025}, }
• (2025). In situ proton-feeding retards the deprotonation for efficient and stable red perovskite light-emitting diodes. ANGEW, 64(29), e202506179. (www)

  @article{ , abstract = {Quasi-two-dimensional (quasi-2D) perovskites have shown great potential in the application of light-emitting diodes (LEDs) due to their large exciton binding energy, tunable bandgaps, and solution processability. However, the heavily used spacer cations will cause serious deprotonation reactions in quasi-2D perovskite films, leading to lattice collapse and abundant defect states, which are notorious for fabricating efficient perovskite LEDs (PeLEDs). Herein, we develop an in situ proton-feeding strategy to restrain the deprotonation process in quasi-2D perovskites by introducing a proton-rich Lewis base, namely trifluoromethyl nicotinic acid (TFNA), into the perovskite precursor solutions. The TFNA molecules can donate protons during the growth of quasi-2D perovskite films to simultaneously compensate the deprotonated spacer cations, passivate the defects states by coordinating with Pb 2+ , and improve structural stability by forming hydrogen bonds with organic spacers. This leads to an enhanced photoluminescence quantum yield of 78.8%. The resulting red-emitting quasi-2D PeLEDs achieved a high external quantum efficiency of 27.5% at 660 nm, accompanied by a 3.5-fold enhancement of the operational lifetime ( T 50 ) compared to that of the reference device based on pristine perovskite. This work deepens the understanding of the crystallization of quasi-2D perovskite films and provides a new avenue to improve the PeLEDs performance.}, archive = {J_ANGEW}, author = {Jie Feng and Sitao Huo and Xudong Jin and Zirui Liu and Nan Liu and Chaohui Liang and Lingmei Kong and Sheng Wang and Lin Wang and Xuyong Yang}, doi = {10.1002/anie.202506179}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ proton-feeding retards the deprotonation for efficient and stable red perovskite light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bonding-driven site-selective activation of α-C(sp3)─H in alcohols: A straightforward dual-catalysis strategy for efficient acceptorless dehydrogenation. ANGEW, 64(29), e202506022. (www)

  @article{ , abstract = {The transformation of alcohols into corresponding carbonyl derivatives is of paramount importance for the construction of complex molecules. Current strategies for catalytic acceptorless dehydrogenation of alcohols were predominantly confined to reactive alcohols, such as benzyl or allyl alcohols, due to the relatively high α-C(sp 3 )─H bond dissociation energy of the conventional unreactive alcohols. Notably, weak bond catalysis, particularly hydrogen bonding, can selectively activate C─H bonds by modulating the distribution of electron density. Herein, we have developed a dual-catalysis platform that enabled highly efficient oxidation of alcohols promoted by a multifunctional catalyst. This strategy achieves selective activation of the hydroxyl α-C(sp 3 )─H bond via hydrogen bonding interactions and polarity matching, which is compatible with both primary and secondary alcohols, demonstrating potential applications in pharmaceutical synthesis. Moreover, DFT studies provide compelling evidence that hydrogen-bond interactions between 3-quinuclidinone and alcohols play a pivotal role in enhancing the catalytic efficiency.}, archive = {J_ANGEW}, author = {Bin Sun and Shuangshuang Zhou and Jiayin Wang and Xuejing Xu and Xiaohui Zhuang and Weike Su and Can Jin}, doi = {10.1002/anie.202506022}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202506022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bonding-driven site-selective activation of α-C(sp3)─H in alcohols: A straightforward dual-catalysis strategy for efficient acceptorless dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Enhancing cold adaptation of bidomain amylases by high-throughput computational engineering. ANGEW, 64(29), e202505991. (www)

  @article{ , abstract = {Cold-adapted bidomain enzymes have the potential to foster industrial sustainability by reducing energy consumption and greenhouse gas emissions. Despite their allure, these benefits are unattainable, as the molecular basis of cold adaptation remains elusive, and there are no strategies to guide the acquisition of this behavior. To uncover principles of cold adaptation, we selected the cold-adapted Saccharophagus degradans amylase (sdA) and mesophilic Pseudomonas saccharophila amylase (psA) as model systems. Through molecular dynamics (MD) simulations and biochemical assays, we found that sdA exhibits significantly greater interdomain separation between its catalytic domain (CD) and carbohydrate-binding module (CBM) at low temperatures. Therefore, we introduce the domain separation index metric to guide the in silico screening of 120 psA variants using high-throughput enzyme modeling. The highest-ranked variant, psA121, shows a 3-fold increase in relative activity over the wild type at 0 °C. MD simulations suggest that psA121 achieves cold adaptation via helical linkers, which induce interdomain separation and enhance flexibility of the active site and binding loops via dynamic allostery, promoting substrate recruitment, binding, and catalysis at lower temperatures. This study highlights how domain separation contributes to cold adaptation in bidomain amylases and offers strategies for introducing such cold adaptation to other systems.}, archive = {J_ANGEW}, author = {Ning Ding and Yaoyukun Jiang and Robbie Ge and Qianzhen Shao and Wook Shin and Xinchun Ran and Zhongyue J. Yang}, doi = {10.1002/anie.202505991}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505991}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing cold adaptation of bidomain amylases by high-throughput computational engineering}, volume = {64}, year = {2025}, }
• (2025). Divergent construction of cyclobutane-fused pentacyclic scaffolds via double dearomative photocycloaddition. ANGEW, 64(29), e202505906. (www)

  @article{ , abstract = {Cyclobutane-fused polycyclic scaffolds are structurally interesting cores in natural product synthesis and drug discovery. The construction of these skeletons often requires elaborate synthetic effort and gives low efficiency. We herein demonstrated the divergent construction of various cyclobutane-fused 2D/3D pentacyclic scaffolds by a photocatalytic intermolecular double dearomative cycloaddition of arenes. These skeletons, typically unattainable under thermal conditions, could be accessed with exclusive diastereoselectivity under mild photochemical conditions. Combined experimental and computational mechanistic studies elucidate that the reaction proceeds through a cascade sequence involving photocatalytic 1,4-hydroalkylation, alkene isomerization, and [2 + 2] cycloaddition via an intertwined single electron transfer (SET)/energy transfer (EnT) nature. This protocol provided a divergent synthetic approach for constructing (pseudo)-dimeric cyclobutane-fused 2D/3D pentacyclic scaffolds. The visible light induced intermolecular double dearomative cycloaddition between naphthalenes and benzothiophenes was also realized, providing indispensable methods for unprecedented structurally diverse polycyclic molecules that were difficult to access by conventional transformations.}, archive = {J_ANGEW}, author = {Ting-Ting Song and Fan Lin and Shan-Tong Xu and Bo-Chao Zhou and Li-Ming Zhang and Shi-Yu Guo and Xinglong Zhang and Qing-An Chen}, doi = {10.1002/anie.202505906}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505906}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent construction of cyclobutane-fused pentacyclic scaffolds via double dearomative photocycloaddition}, volume = {64}, year = {2025}, }
• (2025). Azuperylene: The nonalternant isomer of perylene. ANGEW, 64(29), e202505897. (www)

  @article{ , abstract = {The isoelectronic isomer of perylene, hereafter called as azuperylene, has been prepared. Electronic structure analysis reveals that the new isomer can be described as a union of two antiparallel azulenes in which the azulene-type aromatic character of the starting azulene is partially retained. Four 2,8-dialkoxy (i.e., ethoxy, n -butoxy, n -hexyloxy, and n -octyloxy) functionalized derivatives of the new isomer core have been prepared. The solid-state structures of the new compounds have been resolved showing exceptional herringbone π–π stacking ideal for charge transport. Organic field-effect transistors on sublimated substrates display an excellent hole transport mobility up to 1.03 cm 2 V −1 s −1 that largely surpasses that of perylene and reveals the great potential for charge transport of this new class of nonbenzenoid compounds.}, archive = {J_ANGEW}, author = {Shengpei Liu and Marcos Díaz-Fernández and Menglin Zhang and Fei Huang and Yong Chen and Yudong Yang and José Manuel Marín-Beloqui and Jingbo Lan and Jingsong You and Juan Casado and Cheng Zhang}, doi = {10.1002/anie.202505897}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505897}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Azuperylene: The nonalternant isomer of perylene}, volume = {64}, year = {2025}, }
• (2025). Lewis acidity of the SbCl3/o-chloranil system. ANGEW, 64(29), e202505893. (www)

  @article{ , abstract = {While SbCl 3 is typically inert toward oxidation by ortho -quinones, we use o -chloranil to show that the outcome of such reactions may be altered by the presence of a donor such as triphenylphosphine oxide, which readily traps the SbCl 3 (cat Cl ) synthon (cat Cl = tetrachlorocatecholate) in the form of the corresponding adduct Ph 3 PO→SbCl 3 (cat Cl ). The same reaction in the presence of a chloride salt affords the corresponding antimonate anion [Cl 4 Sb(cat Cl )] − . Computational studies indicate that the putative SbCl 3 (cat Cl ) synthon has a higher chloride ion affinity than SbCl 5 , suggesting significant Lewis acidity. This property is further demonstrated by the use of the SbCl 3 / o -chloranil system for both THF polymerization and a Friedel–Crafts-type alkylation of benzene using 1-fluorooctane. Finally, the reaction of E -stilbene with o -chloranil in the presence of SbCl 3 affords the corresponding benzodioxene, suggesting that SbCl 3 may also operate as a redox-active catalyst.}, archive = {J_ANGEW}, author = {Ferit Şit and Nathanael H. Hunter and Logan T. Maltz and François P. Gabbaï}, doi = {10.1002/anie.202505893}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lewis acidity of the SbCl3/o-chloranil system}, volume = {64}, year = {2025}, }
• (2025). Supramolecular polyanions as effective interphase layers for anode-free lithium metal batteries. ANGEW, 64(29), e202505794. (www)

  @article{ , abstract = {Supramolecular polymers (SPs) driven by host–guest interactions have seen considerable advancements over the past decade, but the guest species involved are predominantly neutral molecules or cations. Strong and dependable macrocycle–anion interactions for supramolecular polymerization are highly sought after, yet the functionalities of this class of SPs featuring negatively charged backbones remain largely unexplored. Here, we report a novel host–guest interaction between one tetraurea macrocycle and two organophosphate anions with high affinity (association constant K a = 1.06 × 10 9 M −2 ). It can serve as noncovalent joints to efficiently link low-molecular-mass polyethylene oxide (PEO) diorganophosphates into long linear SPs. Being used as an interphase layer in anode-free lithium (Li) metal batteries, the polymer material promotes Li + absorption and desolvation through electrostatic attractions and enables fast Li + transport by the alternatingly arranged anionic linkages and PEO units in the polymer main chain. As a result, the SP layer homogenizes Li + flux to achieve uniform Li deposition and significantly improves the electrochemical performance of LiFePO 4 full batteries by a factor of 285% with cycling stability over 200 cycles. These findings pave the way for a new family of anion-based SPs with tunable architectures and compositions and suggest their promising applications in future batteries.}, archive = {J_ANGEW}, author = {Jinghan Li and Yupo Xu and Wei You and Chengkai Hong and Shui Yu and Zhaofeng Ouyang and Zhaoming Zhang and Wei Yu and Hao Sun and Chunyang Yu and Wenfeng Jiang and Yongfeng Zhou}, doi = {10.1002/anie.202505794}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505794}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular polyanions as effective interphase layers for anode-free lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Biomimetic hydrogen-bonded base pairing of nucleoside triphosphates in water by a tetraphenylethene-based octaimidazolium cage. ANGEW, 64(29), e202505732. (www)

  @article{ , abstract = {Studying biomimetic hydrogen-bonded (H-bonded) base pairing of nucleoside triphosphates (NTPs) in aqueous solutions using artificial recognition systems can enhance our understanding of the principles of base pairing in natural systems. Here, we report a water-soluble tetraphenylethene-based octaimidazolium cage ( 1 ) as an artificial host, which promotes the biomimetic H-bonded base pairing of NTPs in water by forming their 1:1:1 hetero-ternary or 1:2 homo-ternary host-guest complexes. Both the matched and mismatched H-bonded base pairs of NTPs are stably captured within the cavity of 1 through the multiple noncovalent interactions of hydrogen bonds, CH⋯π/π⋯π interactions, electrostatic forces, and hydrophobic effect. ITC studies reveal the aqueous biomimetic recognition of 1 for these base pairs is dominantly driven by either classical (entropy-driven, Δ S ≥ 0) or non-classical (enthalpy-driven, Δ H ≪ 0) hydrophobic effects. The X-ray structure of the 1 •GTP 2 complex shows an unprecedented base pair (G:G*) with Watson-Crick H-bonded pattern, resulting from the prototropic tautomerism of normal guanine (G) to tautomeric guanine (G*). Through adaptive host-guest chirality transfer, 1 can also act as a chiroptical sensor, exhibiting differentiated circular dichroism (CD) for these base pairs and enabling dynamic CD inversion to monitor the pH-dependent transformation of GTP base pairs.}, archive = {J_ANGEW}, author = {Yingjie Li and Lin Cheng and Pingxia Wang and Xuhao Kang and Qingfang Li and Liping Cao}, doi = {10.1002/anie.202505732}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505732}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biomimetic hydrogen-bonded base pairing of nucleoside triphosphates in water by a tetraphenylethene-based octaimidazolium cage}, volume = {64}, year = {2025}, }
• (2025). On the role of molecular conformation of the passivating agents for high-performance perovskite solar cells. ANGEW, 64(29), e202505667. (www)

  @article{ , abstract = {Molecular structure engineering of passivating agents has proven to be a pivotal strategy for developing high-performance perovskite solar cells (PSCs). Although previous studies have focused on molecular configuration design, the influence of molecular conformations on device performance remains largely unexplored. Herein, we systematically investigate this critical factor by developing a series of diammonium iodide passivators with tunable conformational rigidity through aryl or alkyl group modifications. Notably, PSC performance exhibits a consistent enhancement with increasing rotational flexibility of the ammonium groups. Detailed carrier dynamics analysis reveals a direct correlation between molecular conformational freedom and defect passivation effectiveness. Theoretical calculations demonstrate that both static geometric matching and dynamic conformation adaptability to perovskite lattice defects govern the passivation quality. The optimized passivator with maximum conformational flexibility enables PSCs to achieve a champion power conversion efficiency of 26.6% (certified stabilized efficiency: 26.4%). This study establishes molecular conformation engineering as a crucial dimension in defect passivation strategies and provides fundamental insights for advancing perovskite photovoltaics.}, archive = {J_ANGEW}, author = {Tie Zhang and Jike Ding and Guofeng You and Jing Liu and Yingwu Tao and Wansheng Zong and Chengjun Fang and Jiajun Wang and Yang Shen and Hongzheng Chen and Cong Chen and Lijian Zuo}, doi = {10.1002/anie.202505667}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On the role of molecular conformation of the passivating agents for high-performance perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Rhodium-catalyzed intermolecular arylative [2 + 2 + 1] Annulation–Oxidation to produce electron-deficient azulene-embedded polycyclic aromatic hydrocarbons. ANGEW, 64(29), e202505622. (www)

  @article{ , abstract = {Azulene derivatives have attracted much attention for their application in organic electronic materials and devices because of their large dipole moment and small HOMO–LUMO energy gap. As these physical properties of azulene depend on its substitution and condensation patterns, developing methods to synthesize functionalized and π-extended azulenes is desirable. However, synthesizing π-extended azulenes requires harsh reaction conditions, making it hard to achieve both functionalization and π-extension. Here, we report the synthesis of electron-deficient azulene-embedded polycyclic aromatic hydrocarbons (PAHs) with two alkoxycarbonyl groups by the rhodium-catalyzed intermolecular arylative [2 + 2 + 1] annulation of teraryl diynes with dialkyl acetylenedicarboxylates followed by oxidation at room temperature. Interestingly, for the electron-rich diyne, prolonged oxidation time after the arylative [2 + 2 + 1] annulation yields a helicene-like bis(azulene-embedded PAH) in good yield. Thus, obtained electron-deficient fused azulenes have small HOMO–LUMO energy gaps (up to E g elec = 1.52 and E g theo = 2.06), resulting in long-wavelength absorption extending into the near-infrared region. Due to bulky electron-withdrawing groups and π-extension, the molecule becomes saddle-shaped and highly polarized, and strong π–π stacking interactions are observed in both the solid and solution states.}, archive = {J_ANGEW}, author = {Yoshinobu Kamiya and Yu Sato and Tomohiro Oriki and Yuko Kishida and Haruki Sugiyama and Waner He and Kexiang Zhao and Tsuyoshi Michinobu and Hidehiro Uekusa and Ken Tanaka}, doi = {10.1002/anie.202505622}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505622}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhodium-catalyzed intermolecular arylative [2 + 2 + 1] Annulation–Oxidation to produce electron-deficient azulene-embedded polycyclic aromatic hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). Electronic state modulation of a single-cu site on a bimetallically doped titanium-oxo cluster to enhance CO2 storage. ANGEW, 64(29), e202505584. (www)

  @article{ , abstract = {While atomically monodisperse nanostructured materials with controllable heterometal dopants are highly desirable to unravel the structure–catalysis relationships, their controlled synthesis and atomic-level structural determination remain significant challenges. Here, we report on nanosized titanium-oxo clusters featuring two heterometallic sites, Ti 10 M 2 O 8 Sal 6 (HSal) 2 (OCH 3 ) 16 (CH 3 OH) 4 (denoted as TiM 2 ; M 2 = MnCu, CaCu, Cu 2 , Mn 2 , Ca 2 ; Sal and HSal represent salicylate and 2-hydroxybenzoate, respectively), which were used for catalyzing and photocatalyzing the CO 2 /epoxide cycloaddition to synthesize cyclic carbonates. Notably, the valence state of Cu is modulated by Mn in the TiMnCu cluster as Cu exists in the δ+ valence (1 < δ < 2), whereas in TiCu 2 and TiCaCu , Cu is + 2 valence. TiMnCu exhibited the highest catalytic activity and selectivity with 1 atm CO 2 , and also effective activity using simulated flue gas. Experiments and density functional theory simulations revealed that CO₂ activation is the rate-determining step, with the reduced valence of Cu promoting CO₂ activation and positioning the adsorbed CO₂ closer to the epoxide, thereby facilitating the cyclization process. Our study underscores that in metal-oxide supports with heterometal centers, the modulation of electronic states by the different heterometals can significantly enhance catalytic performance.}, archive = {J_ANGEW}, author = {Juan Wang and Fangfang Gao and Dexin Wang and Yuting Li and Linping Liu and Guanyun Zhang and Guo Wang and Chen-Ho Tung and Yifeng Wang}, doi = {10.1002/anie.202505584}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic state modulation of a single-cu site on a bimetallically doped titanium-oxo cluster to enhance CO2 storage}, volume = {64}, year = {2025}, }
• (2025). Modulating electric double layers via polymer electric dipole effects to enhance stability in quasi-solid-state sodium metal batteries. ANGEW, 64(29), e202505509. (www)

  @article{ , abstract = {The interfacial instability of Na metal anodes poses a significant barrier to the practical applications of sodium metal batteries. According to electric double layer (EDL) theory, the potential difference in the Helmholtz layer critically affects electrochemical reactions at the electrode/electrolyte interfaces, which governs the solid electrolyte interphase (SEI) composition and the Na deposition process. Herein, we leverage the electric dipole effect of polymers, formed via in situ polymerization of butyl acrylate (BA), which preferentially adsorbs on the Na metal surface, to modulate the conformation of the EDL. Molecular dynamics simulations reveal that poly-BA facilitates the formation of a more compressed diffuse layer and reduces the potential difference in the Helmholtz layer. This compressed EDL with the change of species derives homogeneous SEI, enabling reversible Na plating/stripping. As a result, the poly-BA quasi-solid electrolyte extends the lifespan of the Na||Na cell to 3500 h at 0.1 mA cm⁻ 2 . Quasi-solid-state Na||Na 3 V 2 (PO 4 ) 3 cells maintain stable cycling over 1500 cycles, with a capacity retention of 87.6% at 5 C. Our findings indicate that modulating the EDL structure via the electric dipole effect of polymers enables uniform Na deposition, offering a promising strategy for designing electrolytes for practical quasi-solid-state sodium metal batteries.}, archive = {J_ANGEW}, author = {Zhiyong Li and Jianxiong Chen and Qiu Fang and Jialong Fu and Yi Ren and Xuefeng Wang and Xin Guo}, doi = {10.1002/anie.202505509}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505509}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating electric double layers via polymer electric dipole effects to enhance stability in quasi-solid-state sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). N-insertion of diazonium salts into ketone derivatives. ANGEW, 64(29), e202505341. (www)

  @article{ , abstract = {We report a new oxidative nitrogen insertion into cyclic ketones using readily available diazonium salts. In the case of indanones, the reaction is promoted by auto-catalytically generated Brønsted acid and proceeds via sequential α-diazenylation and ring expansion through an N-iminoaziridinium intermediate. For less α-acidic ketones, a complementary strategy employing silyl enol ethers was developed: catalyzed by HNTf 2 , efficient nitrogen insertion occurred into silyl enol ethers derived from a broad range of four- to seven-membered cyclic ketones. The resulting N-aminoamides exhibit broad synthetic utility in various downstream transformations. Notably, a ring expansion, followed by N─N bond cleavage offers a powerful tool for skeletal editing, converting indanones into isoquinolinones, as demonstrated by the scaffold modification of donepezil.}, archive = {J_ANGEW}, author = {Mohammed Anif Pasha and Jiwon Jang and Youngjin Bae and Seunghoon Shin}, doi = {10.1002/anie.202505341}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505341}, shortjournal = {Angew. Chem. Int. Edit.}, title = {N-insertion of diazonium salts into ketone derivatives}, volume = {64}, year = {2025}, }
• (2025). Crystallization of L-cysteine in heavy water induces intrinsic fluorescence. ANGEW, 64(29), e202505331. (www)

  @article{ , abstract = {Developing noninvasive techniques that can probe how solvents modulate the nucleation pathways of bioorganic molecules in solution remains an active and open area of research. Herein, we investigate the crystallization of the amino acid L-Cysteine and show that both the structure of the crystal and its intrinsic fluorescence can be drastically altered by the solvent. Crystals formed in heavy water exhibit markedly different intermolecular packing as well as strikingly different monomer conformations compared to those in light water. Remarkably, these differences in the supramolecular packing result in significantly elevated intrinsic fluorescence in the crystal that is formed in heavy water. Using a combination of experimental techniques and advanced electronic structure approaches, we elucidate the molecular interactions within the crystals that govern both the electronic origins and the intensity of their emission. These findings demonstrate how tuning the solvent by changing its isotope leads to the emergence of design principles for new intrinsic fluorophores that could serve as novel sensing probes for biomedical applications.}, archive = {J_ANGEW}, author = {Debarshi Banerjee and Sonika Chibh and Om Shanker Tiwari and Gonzalo Díaz Mirón and Marta Monti and Hadar R. Yakir and Shweta Pawar and Dror Fixler and Linda J. W. Shimon and Ehud Gazit and Ali Hassanali}, doi = {10.1002/anie.202505331}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505331}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystallization of L-cysteine in heavy water induces intrinsic fluorescence}, volume = {64}, year = {2025}, }
• (2025). Supramolecular entanglement driven emissive aggregate densification enabling room-temperature phosphorescence hydrogels with ultrastretchability and crack-tolerance. ANGEW, 64(29), e202505192. (www)

  @article{ , abstract = {Polymeric room temperature phosphorescence (RTP) hydrogels are emerging candidates for many advanced photonic applications. Unfortunately, phosphorescence of the introduced RTP chromophores can easily be quenched in water-swollen hydrogel networks, limiting their luminescence performance and application adaptability. Herein, we propose a supramolecular confinement-entanglement synergy strategy to produce ultrastretchable RTP hydrogels by in-situ polymerizing high-concentration 2-(acryloyloxy)ethyl trimethylammonium chloride (AETC) in the presence of preassembled 4-biphenylboronic acid@β-cyclodextrin (4-BB@β-CD) emissive aggregates. The hyper-entangled poly(AETC) (PAETC) chains, formed under water-limiting conditions, synergistically densify the 4-BB@β-CD aggregates through supramolecular confinement, effectively suppressing molecular vibrations and stabilizing triplet states. Impressively, the hydrogels exhibit intense afterglow and ultralong phosphorescence lifetime up to 1.1 s under room conditions. Crucially, the entanglement-dominated physical network free of static chemical crosslinking enables continuing chain disentanglement during stretching for efficient energy dissipation. Segment length between physical entanglement points can thus be significantly enlarged to reduce network fracture and avoid crack propagation, achieving record-breaking uniaxial/biaxial (21 000%/10 000%) stretchability. Even the notched hydrogels are capable of being unprecedentedly stretched to 20 500% and exhibit a fracture energy as high as 157 kJ m⁻ 2 , demonstrating intrinsic crack-tolerance. This study opens new avenues of polymeric RTP hydrogels by bringing superior mechanical performance and should merit their application exploration.}, archive = {J_ANGEW}, author = {Weihao Feng and Fen Li and Zhenyi Jiang and Chaojun Yue and Guangqiang Yin and Ning Zhu and Kai Zhang and Tao Chen and Wei Lu}, doi = {10.1002/anie.202505192}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505192}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular entanglement driven emissive aggregate densification enabling room-temperature phosphorescence hydrogels with ultrastretchability and crack-tolerance}, volume = {64}, year = {2025}, }
• (2025). A solid polymer electrolyte with inorganic-enriched cathode electrolyte interphases enabling 5.1 v solid-state lithium-ion batteries. ANGEW, 64(29), e202505147. (www)

  @article{ , abstract = {Manufacturing solid polymer electrolytes (SPEs) is an effective strategy for pursuing safe, energy-dense solid-state lithium-ion batteries (SSLIBs). However, the challenges lie in obtaining high-voltage SSLIBs due to the lack of an electrochemically stable SPE and the degradation of the high-voltage cathode beyond 5 V. Hence, we employed quantum chemical calculations to screen a poly(vinylidene fluoride-co-trifluoroethylene-co-chlorotrifluoroethylene) (PVDF-TrFE-CFE, designated as PVTF) polymer with strong antioxidant capability to fabricate stable SPEs for high-voltage SSLIBs. Furthermore, a sacrificial additive (lithium difluorophosphate, LiDFP) was introduced in PVTF SPE to build a high-quality cathode electrolyte interphase (CEI) layer to stabilize the LiNi 0.5 Mn 1.5 O 4 (LNMO) cathode, which is denoted as PVTF1.0@LiDFP. The Li|PVTF1.0@LiDFP|LiNi 0.5 Mn 1.5 O 4 (LNMO) cell operating at 5.1 V sustains excellent cycling performance and remarkable rate performance, maintaining a long cycle life of over 200 cycles and achieving a high-rate capability of up to 2 C. Complementary characterization methods were utilized to dynamically observe the cathode structure and interphase evolution, revealing that the high antioxidant stability of the polymeric PVTF framework and the incorporation of LiDFP additive to form a high-quality CEI enriched with inorganic components realize the superior performance of Li|PVTF1.0@LiDFP|LNMO cell. Overall, the insights gained from our study provide a solid foundation for the development of high-voltage SSLIBs.}, archive = {J_ANGEW}, author = {Yue Hou and Yiqiao Wang and Zhiquan Wei and Zhuoxi Wu and Dedi Li and Qing Li and Shimei Li and Ze Chen and Yanbo Wang and Guojin Liang and Ke Wang and Chunyi Zhi}, doi = {10.1002/anie.202505147}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A solid polymer electrolyte with inorganic-enriched cathode electrolyte interphases enabling 5.1 v solid-state lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Fluoride enhances alcohol binding within a trigonal-prismatic metal-organic capsule. ANGEW, 64(29), e202505137. (www)

  @article{ , abstract = {Herein we utilize the binding of fluoride to boron atoms to functionalize the interior of a boron-containing trigonal prismatic capsule that incorporates two triangular and three rectangular ligands, enabling the tuning of its guest binding properties. The methyl groups of the triangular ligands guide the rectangular ligands to adopt a “landscape” orientation to avoid steric hindrance. This small structural change gives rise to an enlarged interior cavity volume for guest encapsulation, as compared with a previously-reported trigonal prismatic capsule, where the same rectangular ligand took a “portrait” orientation with a non-methylated triangular ligand of similar size. The methylated triangular ligand contains a boron core, which can bind fluoride ions that point inward. These bound fluorides serve as hydrogen bond acceptors, which increases the affinity of the capsule for hydrogen-bond-donating alcohols, which are bound in preference to ketones of similar sizes. Moreover, this boron-containing trigonal prism selectively binds perrhenate over perchlorate, while fluoride binding modulates the cavity charge, leading to perrhenate ejection. These and similar endo -functionalized capsules may thus be of use in the fields of molecular recognition and separation.}, archive = {J_ANGEW}, author = {Yuchong Yang and Tanya K. Ronson and Dingyu Hou and Kai H. Luo and Jonathan R. Nitschke}, doi = {10.1002/anie.202505137}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505137}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluoride enhances alcohol binding within a trigonal-prismatic metal-organic capsule}, volume = {64}, year = {2025}, }
• (2025). Crystallization/Precipitation driven nonequilibrium ring-opening polymerization of thiovalerolactone toward closed-loop recyclable polythioester with excellent barrier properties. ANGEW, 64(29), e202505104. (www)

  @article{ , abstract = {The development of closed-loop recyclable polymers with comparable performances with commodity plastics remains as a challenge to establish a circular plastic economy. In this contribution, we propose a precipitation/crystallization driven nonequilibrium ring-opening polymerization of δ-thiovalerolactone (δTVL) to produce high-molecular-weight PTVL in the presence of a strong base/urea binary catalyst. The obtained PTVL exhibits good thermal and mechanical performances as well as superior barrier properties comparable with some commodity plastics. Remarkably, the obtained PTVL can be depolymerized to recover pristine monomer with a high yield and purity by distillation from a commodity plastic waste mixture without tedious separation, highlighting its great potential as a closed-loop recyclable packaging material.}, archive = {J_ANGEW}, author = {Weijie Pei and Yiming Liu and Qin Yan and Kunlun Yuan and Sai Li and Yong Shen and Zhibo Li}, doi = {10.1002/anie.202505104}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystallization/Precipitation driven nonequilibrium ring-opening polymerization of thiovalerolactone toward closed-loop recyclable polythioester with excellent barrier properties}, volume = {64}, year = {2025}, }
• (2025). Dynamic migration-pulling polymer electrolyte design strategy for low-temperature Lithium–Sulfur batteries. ANGEW, 64(29), e202505095. (www)

  @article{ , abstract = {Quasi-solid-state lithium–sulfur batteries exhibit significant promise as safe, high-energy electrochemical storage technology, yet their performance remains constrained by polysulfide accumulation and exacerbated shuttle effects due to sluggish redox kinetics and inefficient charge transport. Here, a dynamic migration-pulling strategy is proposed to accelerate polysulfide redox kinetics by dynamically restructuring the solvated structure of Li + , which is validated on a GPE incorporating boronic ester dynamic covalent bonds and polar side chains (BE-GPE). Theoretical calculations and experiments revealed that the desolvation barrier for Li + is significantly reduced, while the ligand groups were pulled out from the solvated shell assisted by the migration of dynamic covalent bonds. Rapid charge transfer kinetics are attainable via designed electrolyte. Consequently, BE-GPE based lithium–sulfur batteries delivered high reversible capacity of 1446 mAh g −1 at 0.1 C and long-term cycling stability with an average capacity decay of 0.04% during 1000 cycles at 0.5 C. The initial capacity at 0.5 C is up to 920 mAh g −1 and remains stable for 200 cycles at 0 °C. Successfully realized the energy storage of quasi-solid-state Li–S batteries under low-temperature conditions.}, archive = {J_ANGEW}, author = {Wenkai Song and Borui Li and Yunpeng Qu and Wanyuan Jiang and Mengfan Pei and Naiwen Hu and Shuo Zhuo and Chang Su and Xin Jin and Runyue Mao and Dongming Liu and Xigao Jian and Fangyuan Hu}, doi = {10.1002/anie.202505095}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic migration-pulling polymer electrolyte design strategy for low-temperature Lithium–Sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Unlocking lactonase enzymes as biocatalysts for the deracemisation of chiral γ-thiolactones. ANGEW, 64(29), e202505032. (www)

  @article{ , abstract = {Lactonases, a class of metalloenzymes that exhibit catalytic promiscuity, have been extensively studied from a biological perspective, yet their application as biocatalysts remains underexplored. In this study, we disclose the biocatalytic activity of lactonase enzymes in the hydrolysis and deracemisation of chiral C3-substituted-γ-thiolactones and the asymmetric synthesis of γ-thio-α-substituted-carboxylic acids. The thiolactonase activity of lactonases from different protein superfamilies was investigated. The biocatalyst GcL, from the metallo-β-lactamase-like lactonase family, catalysed the enzymatic kinetic resolution (EKR) of homocysteine (Hcy) thiolactones with excellent enantioselectivity ( E -value up to 136), yielding enantioenriched Hcy thiolactones and γ-thio-α-amino-carboxylic acids with high ees. Additionally, the biocatalyst N9 Y71G, a rationally engineered variant of the reconstructed ancestral paraoxonase enzyme N9, catalysed the dynamic kinetic resolution (DKR) of C3-thio-γ-thiolactones, yielding γ-thio-α-thio-carboxylic acids in enantioselective manner with high ees (up to >99%) and yields (up to >99%). Insights on the mechanism and the stereoselectivity of the lactonase biocatalysts were gained through computational and site-directed mutagenesis studies.}, archive = {J_ANGEW}, author = {Jingyue Wu and Michele Crotti and Ivan Bassanini and Mahdi Hassankalhori and Erica Elisa Ferrandi and Ferran Sancho and Daniela Monti and Daniele Castagnolo}, doi = {10.1002/anie.202505032}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202505032}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking lactonase enzymes as biocatalysts for the deracemisation of chiral γ-thiolactones}, volume = {64}, year = {2025}, }
• (2025). Intracellular polymerization induced self-assembly and gold nanocomposite synthesis in living bacteria. ANGEW, 64(29), e202504936. (www)

  @article{ , abstract = {In this paper, we present a novel intracellular strategy for the in situ synthesis of gold-polymer nanocomposites within living bacteria. By transforming Escherichia coli into active nanofactories via intracellular polymerization-induced self-assembly (iPISA), we achieved precise control over composite architecture. Our findings indicate that bacterial cells play an active role in constructing complex nanomaterials, offering new perspectives for the sustainable synthesis of nanocomposites and the integration of biological systems in materials fabrication.}, archive = {J_ANGEW}, author = {Shiling Zhang and Jinying Yang and Jinyan Luo and Jiao Zhang and Mianqi Huang and Kui Tan and Gaojian Chen and Qi Xing and Hang Fai Kwok and Zhuojun Dai and Jin Geng}, doi = {10.1002/anie.202504936}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504936}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intracellular polymerization induced self-assembly and gold nanocomposite synthesis in living bacteria}, volume = {64}, year = {2025}, }
• (2025). Visualization analysis of covalent and noncovalent interactions in real space. ANGEW, 64(29), e202504895. (www)

  @article{ , abstract = {Understanding the types and locations of interactions between atoms or molecules within a chemical system is a fundamental concern in chemistry. In the field of theoretical and computational chemistry, wavefunction analysis offers various methods based on functions defined in 3D real space, enabling the visual representation of both covalent and noncovalent interactions. These methods provide researchers with an intuitive understanding of molecular interactions and are gaining increasing attention. This review systematically introduces various widely adopted and distinctive visualization methods, such as the noncovalent interaction (NCI) method, the independent gradient model based on Hirshfeld partition of molecular density (IGMH), the interaction region indicator (IRI), the electrostatic potential (ESP), the electron localization function (ELF), and deformation density. Additionally, numerous application examples are provided to help readers recognize the significant practical value of these methods. Also the computer program Multiwfn, which effectively implemented all the introduced methods, is briefly mentioned.}, archive = {J_ANGEW}, author = {Tian Lu}, doi = {10.1002/anie.202504895}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504895}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visualization analysis of covalent and noncovalent interactions in real space}, volume = {64}, year = {2025}, }
• (2025). Molecular design of polymeric Metal–Organic nanocapsule networks for solid-state lithium batteries. ANGEW, 64(29), e202504767. (www)

  @article{ , abstract = {Solid-state electrolytes (SSEs) have emerged as high-priority materials for ensuring the safe operation of solid-state lithium (Li) batteries. However, current SSEs still face challenges of balancing stability and ionic conductivity, which limits their practical applications in solid-state Li batteries. Here, we report a general strategy for achieving high-performance SSEs by constructing a Li + -conducted polymeric metal–organic nanocapsule (PolyMONC(Li)) network through molecular design. With the unique cage structure and pore size, metal–organic nanocapsule (MONC) can achieve excellent anion confinement effects. The PolyMONC(Li) network with continuous Li + conduction pathways serves as a solid electrolyte exhibiting a high ionic conductivity (0.18 mS cm −1 at 25 °C) and a high Li + transference number (0.83). Combining the two superiorities of optimal balance between mechanical strength and excellent Li + conductivity, the PolyMONC(Li) can still restrain the dendrite growth and prevent Li symmetric batteries from short-circuiting even over 900 h cycling. The PolyMONC(Li)-based SSEs Li-metal batteries achieved a higher specific capacity than common polymer electrolytes such as polyethylene oxide-based SSE. Additionally, taking advantage of the PolyMONC(Li) electrode binder, the solid-state Li–O 2 battery achieves a stable cycling over 400 cycles. This work provides a comprehensive guideline for developing porous solids from molecule design to practical application.}, archive = {J_ANGEW}, author = {Xin-Yue Ma and Xiao-Xue Wang and De-Hui Guan and Cheng-Lin Miao and Huan-Feng Wang and Qing-Yao Zhu and Ji-Jing Xu}, doi = {10.1002/anie.202504767}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504767}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular design of polymeric Metal–Organic nanocapsule networks for solid-state lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Hydroenergy inspiring large-scale piezoelectric catalysis for seawater hydrogen evolution. ANGEW, 64(29), e202504749. (www)

  @article{ , abstract = {The piezoelectric effect presents a promising avenue for harvesting and utilizing low-grade mechanical energy. However, challenges from lacking matched industrial equipment and maintaining catalytic performance during scaling up impede the engineering of piezo-catalysis. Here, utilizing mechanical energy of water to inspire piezoelectricity, a successful attempt at large-scale piezo-catalysis seawater H 2 evolution was reported for the first time, exhibiting an efficiency of 36.82% for converting mechanical energy to hydrogen energy. A scaling-up test with 20 L of seawater was conducted, yielding an H 2 production rate of 0.73 L h −1 , which just occupied 0.7 m 2 . This performance (1.04 L h −1 m −2 ) exceeds the large-scale photocatalytic pure water H 2 production by panel reactor array (0.18∼0.25 L h −1 m −2 ) reported in 2021. Additionally, the H 2 evolution activity of the 20 L system showed no obvious decline compared with the 50 mL system before scaling-up, owing to the utilization of ternary piezo-catalysts system, which capitalized on the synergistic coupling effect of kinetics and thermodynamics. This attempt provides a prototype for pursuing large-scale piezo-catalysis and practical engineering application.}, archive = {J_ANGEW}, author = {Wenyuan Liu and Shu Zhu and Maoxi Ran and Zhihao Fu and Mengke Zhang and Yayun Zhang and Hualin Wang and Mingyang Xing and Pengbo Fu}, doi = {10.1002/anie.202504749}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydroenergy inspiring large-scale piezoelectric catalysis for seawater hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Bright and fast-response hybrid X-ray scintillators by molecular and dielectric confinement. ANGEW, 64(29), e202504576. (www)

  @article{ , abstract = {Scintillators featuring bright and fast-response properties are essential for high-speed and dynamic X-ray imaging. Nevertheless, simultaneously possessing high light yields and fast-response remains a significant challenge for most scintillators. Herein, we propose a strategy to achieve the bright and fast-response characteristics of scintillators by leveraging the combined effects of dielectric and molecular confinement in organic–inorganic hybrid scintillators (TPA) 2 MnBr 4 . Thereinto, large tetrapropylammonium cations (TPA + ) surround [MnBr 4 ] 2− units, forming a zero-dimensional (0D) molecular confinement structure that promotes electron localization and achieves a notable light yield of 56800 photons MeV −1 . Meanwhile, the low dielectric constant of TPA + can enhance dielectric confinement of [MnBr 4 ] 2− units, mitigating exciton capture by deep defects. These synergistic effects in the scintillators lead to a large exciton binding energy of 1028.8 meV and an ultrafast response time of 500 fs. Notably, under the irradiation of X-rays, (TPA) 2 MnBr 4 exhibits an extremely low detection limit of 18.7 nGy air s −1 and an exceptional spatial resolution of 21.0 lp mm −1 . Given the bright and fast-response features of scintillators, we demonstrate the potential applications in 3D dynamic and real-time X-ray imaging. These findings lay the groundwork for designing high-performance scintillators and open avenues for innovative applications in high-resolution and dynamic imaging.}, archive = {J_ANGEW}, author = {Yitong Jiao and Ruizi Li and Haoyang Wang and Weiguo Zhu and Yuan Gao and Feng Xu and Bo Wu and Xiong Huang and Long Gu and Wei Huang}, doi = {10.1002/anie.202504576}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504576}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bright and fast-response hybrid X-ray scintillators by molecular and dielectric confinement}, volume = {64}, year = {2025}, }
• (2025). Dual-interface nanopipette sensor for electrochemical interferent shielding. ANGEW, 64(29), e202504520. (www)

  @article{ , abstract = {Enzyme-based sensors have been widely utilized for their superior selectivity. However, they cannot distinguish the same kind of redox mediators from different sources. Typically, both the H 2 O 2 produced in glucose (analyte) oxidation by glucose oxidase (GOD) and the endogenous H 2 O 2 (interferent) existing in the detection system can be simultaneously measured, causing inaccurate results in glucose detection. To address this long-standing and inevitable obstacle, we proposed a new sensor design strategy, a dual-interface nanopipette sensor (DINS), to shield against the interferent electrochemically. The DINS comprised an anti-interference interface at the orifice of the nanopipette, and a sensing interface located at the inner wall with a certain distance from the orifice. Anti-interference interface, functioning as an “electrochemical Faraday cage”, electrochemically eliminated the interferents with high efficiency while allowed the target species to pass through and be detected at the sensing interface. With the synergy of these two independent interfaces, the GOD-modified DINS (GOD-DINS) allowed the accurate detection of intracellular glucose with effectively eliminating endogenous H 2 O 2 , facilitating the quantitative study on the glucose metabolism inside single cells. Furthermore, this DINS configuration is expected to accurately quantify more substances, and reveal complex crosstalk interactions between multiple species in the physiological, pathological and pharmacological research.}, archive = {J_ANGEW}, author = {Si-Yu Tian and Rui-Xue Gao and Zi-Qiang Du and Yu-Ting Qi and Ying Chen and Fan Xia and Xin-Wei Zhang and Wei-Hua Huang}, doi = {10.1002/anie.202504520}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504520}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-interface nanopipette sensor for electrochemical interferent shielding}, volume = {64}, year = {2025}, }
• (2025). Native mass spectrometry facilitates hit validation in DNA-encoded library technology. ANGEW, 64(29), e202504470. (www)

  @article{ , abstract = {DNA-encoded Library (DEL) Technology has become a workhorse of drug development, is widely employed in an industrial and academic setting, and an increasing number of drugs developed by DEL technology have entered clinical stage development. While up to billions of compounds can be screened simultaneously in affinity-based selections, the validation and characterization of individual hits discovered from DEL selections is a substantial bottleneck since it can be cumbersome and time-consuming. Here, we describe the use of native mass spectrometry for the speedy hit validation of On-DNA compounds. Through the preservation of noncovalent interactions in the gas phase, complexes of proteins and their respective On-DNA ligands can be analyzed without further need of labeling or immobilization. By utilizing the workflow described in this work, we were able to reliably rank affinities of various purified On-DNA binders or demonstrate binding of On-DNA compounds from unpurified mixtures, mitigating the need for tedious purification steps. Additionally, the methodology described here can offer valuable insight on which moiety of a binding molecule contributes the most to binding, facilitating subsequent medicinal chemistry efforts for lead expansion.}, archive = {J_ANGEW}, author = {Philipp Bittner and Andreas Gloger and Michelle Keller and Sebastian Oehler and Alice Lessing and Qi Zhang and Zhongyao Ma and Wenji Su and Alexander L. Satz and Letian Kuai and Renato Zenobi and Jörg Scheuermann}, doi = {10.1002/anie.202504470}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504470}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Native mass spectrometry facilitates hit validation in DNA-encoded library technology}, volume = {64}, year = {2025}, }
• (2025). Fine-tuned charge density of pt single-atom sites for controllable hydrodeoxygenation of lignin. ANGEW, 64(29), e202504347. (www)

  @article{ , abstract = {Achieving high-selectivity conversion of lignin to value-added chemicals and biofuels remains a desirable but challenging target due to its complex structure with multiple reaction paths. Herein, we designed the robust Pt single-atom sites supported on NiAl layered double hydroxide (Pt 1 /NiAl-LDH) and intermetallic compound (Pt 1 /NiAl-IMC) with distinct local charge density for selectivity-controllable hydrodeoxygenation of lignin. The Pt 1 /NiAl-LDH with electron-deficient Pt sites hydrogenated 4-propylguaiacol into 4-propylcyclohexanol with 100% conversion and over 90% selectivity, while Pt 1 /NiAl-IMC with electron-rich Pt sites favored complete deoxygenation, yielding almost equivalent of propylcyclohexane. Similar results were achieved using lignin samples. Density functional theory calculations revealed that the deoxygenation capacity of Pt 1 /NiAl-IMC stems from the high electronic density of Pt single atoms, which injects electrons into the C─O bond and weakens its bonding energy. This study demonstrates that the catalytic performance of single-atom catalysts in biopolymers hydrodeoxygenation can be optimized toward different products by well-controlled electronic structures.}, archive = {J_ANGEW}, author = {Qiqi Dai and Zechuan Xu and Shibin Wang and Xu Zeng and Fan He and Fengxia Yue and Zedong Zhang and Chenliang Ye and Yu Wang and Chuanfu Liu and Peng Wang and Minjie Hou and Ge Meng and Wu Lan and Dingsheng Wang}, doi = {10.1002/anie.202504347}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504347}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fine-tuned charge density of pt single-atom sites for controllable hydrodeoxygenation of lignin}, volume = {64}, year = {2025}, }
• (2025). Selective hydrogenation of phenols to cyclohexanones over hydrotalcite-supported pd single-atom catalyst. ANGEW, 64(29), e202504260. (www)

  @article{ , abstract = {Cyclohexanones are widely used chemicals and currently produced by the oxidation of the fossil feedstocks. Direct selective hydrogenation of lignin derivatives has great potential for producing these chemicals, but is challenging to obtain high yields. Here, we report that hydrotalcite-supported Pd single-atom (Pd/CHT-800) catalyst enabled the hydrogenation of the benzene ring in the aromatics without the overreaction of carbonyl group, which could afford >99.9% yield of cyclohexanones using water as the reaction medium. The reaction mechanism was systematically studied by the control experiments and detailed in situ characterizations. In the Pd/CHT-800 catalyst, the Pd-O-MgAl sites were formed, and the cooperation of the Pd atoms and calcined CHT material could not only realize the aromatic hydrogenation efficiently, but also inhibit the hydrogenation of the carbonyl group in the reaction effectively. This work provides a novel route for the sustainable production of cyclohexanones.}, archive = {J_ANGEW}, author = {Yani Liu and Qinglei Meng and Kaili Zhang and Wanying Han and Xinrui Zheng and Yaqin Wang and Yibo Han and Jingping Wang and Haihong Wu and Mingyuan He and Buxing Han}, doi = {10.1002/anie.202504260}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504260}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective hydrogenation of phenols to cyclohexanones over hydrotalcite-supported pd single-atom catalyst}, volume = {64}, year = {2025}, }
• (2025). Alleviation of precursor degradation induced by DMF/DMSO mixture for enhanced performance of perovskite solar cells. ANGEW, 64(29), e202504253. (www)

  @article{ , abstract = {The precursor quality critically determines the morphology, grain size, crystallinity, and trap state density of the perovskite films. A long shelf life of the perovskite precursor could greatly benefit the reliable upscaling of perovskite solar cells (PSCs). Herein, we suggest that the most commonly used N, N-Dimethylformamide/Dimethyl sulfoxide (DMF/DMSO) mixed solvent exhibits more severe degradation compared to its corresponding single solvents, due to the complex interplay of reactions, including hydrolysis, oxidation, and deprotonation of precursor species in the solution. 2-thiouracil (Th) was thus introduced into the precursor to inhibit these side reaction chains and effectively alleviate the detrimental degradation of cations and iodide ions (I⁻). The synergistic effects of Th allow it to bind with undercoordinated Pb 2+ , modulating the crystallization process and thereby achieving high-quality films with a low defect density. Consequently, Th-based precursor demonstrates enhanced shelf life, retaining 94.78% of the initial efficiency (25.13%) of the device prepared from fresh solution after 30 days of aging, compared to 64.22% for the control sample. The target device also exhibits remarkable stability, maintaining 87.8% of its initial efficiency after 1000 h of maximum power point tracking.}, archive = {J_ANGEW}, author = {Yue Ma and Haoyu Cai and Yongjun Liu and Biqi He and Hongfei Zhang and Yaqi Cheng and Guodong Liu and Juan Zhao and Yi-Bing Cheng and Jie Zhong}, doi = {10.1002/anie.202504253}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504253}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alleviation of precursor degradation induced by DMF/DMSO mixture for enhanced performance of perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Bypassing the nitrido wall using a redox-active isocyanide: Nucleophilic attack on CO by a rhenium nitride complex. ANGEW, 64(29), e202504245. (www)

  @article{ , abstract = {Reactive rhenium(III) nitride complexes could result from filling Re─N π* orbitals, but such complexes lie beyond the “nitrido wall” and are rare due to their instability. Here, we describe a method for bypassing the nitrido wall by incorporating a redox-active isocyanide supporting ligand, which accommodates two electrons as shown by crystallographic, spectroscopic, and computational studies. These electrons can be returned to the metal during its facile reaction with CO to form a cyanate complex, demonstrating the nucleophilic reactivity of the nitride. Thus, assistance by the isocyanide enables an N 2 -derived rhenium nitride to engage in N─C bond forming reactivity.}, archive = {J_ANGEW}, author = {Alexander S. Hegg and Ryan S. Donnelly and Jeremy E. Weber and Robert H. Crabtree and Brandon Q. Mercado and Patrick L. Holland}, doi = {10.1002/anie.202504245}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504245}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bypassing the nitrido wall using a redox-active isocyanide: Nucleophilic attack on CO by a rhenium nitride complex}, volume = {64}, year = {2025}, }
• (2025). Epitaxially grown lattice-coherent surface enabling superior mechanical integrity for high-voltage LiCoO2 cathode. ANGEW, 64(29), e202504221. (www)

  @article{ , abstract = {The growing demand for high-energy-density cathode is pushing LiCoO 2 towards 4.6 V operation. However, the structural and interfacial instability of high-voltage LiCoO 2 is exacerbated when the charging cut-off voltage exceeds 4.55 V, resulting in severe mechanical failure and subsequent dramatic capacity decay. Herein, through thermally driven element interdiffusion, a highly durable Co-containing Li-rich phase with the lattice coherence has been epitaxially grown along LiCoO 2 surface, which enhances the intrinsic mechanical integrity of high-voltage LiCoO 2 . Through establishing the lattice-coherent Li-rich surface, adverse side reactions, irreversible phase transition and lattice oxygen loss are significantly inhibited in high-voltage LiCoO 2 , thereby alleviating cracks formation and maintaining the structural integrity. The presence of the Li-rich phase endows LiCoO 2 with the additional capacity and the excellent cycling stability at 4.6 V and even at 4.7 V. This work taps into a new avenue of surface engineering on high-voltage LiCoO 2 .}, archive = {J_ANGEW}, author = {Xiang Li and Kexin Wang and Miao Tian and Xu Zhang and Xingyang Wu and Haotian Song and Shuo-Wang Yang and Junwei Zheng and Fanghui Du and Jing Lyu and Zhongkai Hao and Guo Qin Xu}, doi = {10.1002/anie.202504221}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Epitaxially grown lattice-coherent surface enabling superior mechanical integrity for high-voltage LiCoO2 cathode}, volume = {64}, year = {2025}, }
• (2025). Staggered ABC-stacking cobalt-triptycene framework for accelerating CO2 photoreduction. ANGEW, 64(29), e202504155. (www)

  @article{ , abstract = {Metal-organic frameworks (MOFs) are highly efficient photocatalysts due to their highly tunable structures and favorable electronic properties. However, achieving control over framework stacking arrangements, such as the staggered ABC-stacking, presents significant challenges. This difficulty arises from the inherently unfavorable energetics of the ABC arrangement and weaker π–π interactions compared to other stacking modes. Herein, a cobalt-triptycene framework with a staggered ABC-stacking arrangement was successfully synthesized in the aqueous phase, achieving a 90% yield. Experimental evaluations revealed that this framework achieved a CO production rate of 4.43 mmol g −1 h −1 , which is comparable to the most reported MOF-based photocatalysts for CO 2 reduction. Moreover, density functional theory (DFT) calculations and molecular dynamics (MD) simulations indicated that the ABC-stacking cobalt-triptycene framework exhibits lower activation energy (0.079 eV) for water molecules, reduced Gibbs free energies for key intermediates *COOH (0.76 eV) and *H (0.73 eV), and the highest reaction rate increment (7.488 times). Furthermore, principal component analysis (PCA) reveals a strong correlation between the CO production rate and factors such as the Ik value, optical bandgap, and Δ G *H , revising the previous held notion that Δ G *COOH is the primary determinant of catalytic performance. These results offer valuable insights into the design principles of advanced photocatalysts for CO 2 reduction.}, archive = {J_ANGEW}, author = {Jun-Hao Wu and Xin-Hui Lu and Qian-Qian Yan and Ji-Xia Qiu and Wei Zhou and Yuan-Yuan Zhu and Xiao Wang and Sheng Zhang and Kui Li and Xing Lu}, doi = {10.1002/anie.202504155}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504155}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Staggered ABC-stacking cobalt-triptycene framework for accelerating CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Modular access to fluorinated quaternary stereocenters via Palladium/Lewis base synergistic catalysis. ANGEW, 64(29), e202504121. (www)

  @article{ , abstract = {The stereocontrolled construction of fluorinated quaternary stereocenters in acyclic systems remains a significant synthetic challenge. We report a synergistic palladium/Lewis base catalytic platform that directly couples α-fluoro-α-aryl acetates with allenes or 1,3-dienes without directing groups. This strategy overcomes traditional limitations in fluoronucleophile activation and stereochemical control, enabling access to diverse acyclic fluorinated architectures. Key to success is the use of axial-chiral Lewis bases, which work cooperatively with palladium catalysts to govern both enantioselectivity and diastereoselectivity. The method accommodates broad substrate scope, including aromatic, heterocyclic, and aliphatic systems, while demonstrating scalability and synthetic versatility through downstream transformations. This work not only bridges essential voids in fluorinated stereochemical space but also enhances the practical applications of synergistic catalyst systems.}, archive = {J_ANGEW}, author = {Rixin Liu and Qinglong Zhang and Zitong Lin and Thomas N. Snaddon and Weiwei Zi}, doi = {10.1002/anie.202504121}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504121}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular access to fluorinated quaternary stereocenters via Palladium/Lewis base synergistic catalysis}, volume = {64}, year = {2025}, }
• (2025). Highly efficient circularly polarized luminescence based on center-chiral frustrated lewis pairs. ANGEW, 64(29), e202504057. (www)

  @article{ , abstract = {Achieving high-efficiency circularly polarized luminescence (CPL) in organic light-emitting diodes (OLEDs) presents a significant challenge, particularly for center-chiral systems, due to the inherent trade-off between high luminescence efficiency and large luminescence dissymmetry factors. In this work, we introduce a center-chiral frustrated Lewis pair (FLP) design to overcome this limitation. By integrating a stereogenic carbon center into a fluorene scaffold, we create a unique interaction between a boron-based multi-resonance (MR) thermally activated delayed fluorescence (TADF) Lewis acid and an arylamine Lewis base. This sterically hindered design prevents strong charge transfer while optimizing the alignment between electric and magnetic dipole moments for amplified CPL signals. Our OLEDs achieve impressive electroluminescence (EL) dissymmetry factors (| g EL |) of 6.64 × 10 −3 , external quantum efficiencies (EQEs) of up to 30.4%, and sub-30 nm spectral linewidths. These improvements yield a Figure of Merit (FoM = EQE × | g EL |) of 1.91 × 10 −3 , the highest reported for center-chiral CPL devices. These findings demonstrate the effectiveness of the center-chiral FLP design in overcoming the long-standing trade-off between polarization and efficiency in CPL devices.}, archive = {J_ANGEW}, author = {Fan Zheng and Xiao-Long Liu and Longjiang Xing and Jia-Ming Jin and Shaomin Ji and Yanping Huo and Wen-Cheng Chen}, doi = {10.1002/anie.202504057}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202504057}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient circularly polarized luminescence based on center-chiral frustrated lewis pairs}, volume = {64}, year = {2025}, }
• (2025). 2D/2D MOF/MXene schottky junction: Prolonged carrier lifetime and enhanced hydrogen evolution efficiency. ANGEW, 64(29), e202503860. (www)

  @article{ , abstract = {Harnessing sunlight for photocatalytic overall water splitting offers a sustainable approach to renewable hydrogen (H 2 ) production, addressing global energy and environmental challenges. However, the development of efficient and durable photocatalysts remains a significant obstacle. This study introduces the design and performance of a 2D/2D Schottky heterojunction composed of Cu 2 [CuTCPP] MOF of nanometric size and exfoliated Ti 3 C 2 MXene for visible-light-driven overall water splitting. By leveraging the extensive interfacial contact between the two components, an interfacial electric field is generated, promoting efficient charge migration and prolonging carrier lifetimes, as confirmed through systematic density functional theory simulations, in situ irradiation X-ray photoelectron spectroscopy, femtosecond transient absorption spectroscopy, and X-ray absorption spectroscopy. Ti 3 C 2 MXene, acting as a cocatalyst for photohole transport and accumulation, reduces oxidative degradation and slows catalyst deactivation. The synergistically enhanced light absorption properties of the Cu 2 [CuTCPP]/Ti 3 C 2 heterojunction result in an impressive H 2 evolution rate exceeding 5000 µmol g cat ⁻ 1 , underscoring its potential for next-generation photocatalytic systems in renewable energy applications.}, archive = {J_ANGEW}, author = {María Cabrero-Antonino and Andrés Uscategui-Linares and Rubén Ramírez-Grau and Pablo García-Aznar and German Sastre and Jianjun Zhang and Sara Goberna-Ferrón and Josep Albero and Jiaguo Yu and Hermenegildo García and Feiyan Xu and Ana Primo}, doi = {10.1002/anie.202503860}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503860}, shortjournal = {Angew. Chem. Int. Edit.}, title = {2D/2D MOF/MXene schottky junction: Prolonged carrier lifetime and enhanced hydrogen evolution efficiency}, volume = {64}, year = {2025}, }
• (2025). High-performance Al–S batteries by spin polarization modulation via catalytic ni-MoS2 nanosheets. ANGEW, 64(29), e202503835. (www)

  @article{ , abstract = {Aluminum–sulfur (Al–S) batteries catalysts with adsorption and catalytic capabilities can effectively improve the slow redox kinetics, but the current research often ignores the effect of optimizing the electronic structure of the catalyst on improving charge transfer and adsorption. Here, Ni-doped monolayer MoS 2 nanosheets are synthesized and used as a catalytic additive for the sulfur cathode. The addition of Ni promotes spin splitting of 4d orbital of Mo, thereby affecting polarization degree of the basal plane sulfur and making it change from a low spin state to a high spin one. This high spin configuration raises the electron energy level and provides an active electron state to react with aluminum polysulfides (AlPSs), which optimizes the adsorption energy. At the same time, it accelerates electron transfer and lowers the energy barrier for the overall conversion of the polysulfides. Benefiting from these features, Al–S batteries based on rationally designed S@Ni-MoS 2 /C cathodes exhibit a high initial capacity (1603.0 mAh g −1 at 0.5 A g −1 ) and extraordinary cycling stability (0.035% capacity decay rate during 2000 cycles). This study showcases a spin-polarized electronic structure control strategy to enhance catalytic activity, providing a viable approach for developing efficient catalysts for practical Al–S batteries.}, archive = {J_ANGEW}, author = {Xiaoya Liu and Xingjun Liu and Jiqiang Zhan and Wang Yuan and Yue Zhu and Weiyuan Huang and Hongpeng Li and Tongchao Liu and Khalil Amine and Hongsen Li and Guihua Yu}, doi = {10.1002/anie.202503835}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503835}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance Al–S batteries by spin polarization modulation via catalytic ni-MoS2 nanosheets}, volume = {64}, year = {2025}, }
• (2025). Defect-driven stepwise activation of Metal–Organic frameworks toward industrial-level anion exchange membrane water electrolysis. ANGEW, 64(29), e202503787. (www)

  @article{ , abstract = {Metal-organic frameworks (MOFs), featuring well-defined metal active sites and unique coordination environment, have recently emerged as ideal model catalysts for establishing precise structure-activity relationships in oxygen evolution reaction (OER). However, elucidating essential catalytic mechanisms responsible for dynamic reaction conditions remain challenging, primarily due to the complicated adsorption behavior and cross-step transfer of key adsorbates during OER. Herein, we propose a defect-driven stepwise activation strategy to meticulously control the adsorption behavior for defective Co-based MOF (termed D/CoFc-MOF) through tailoring the interplay between local coordination geometry and electronic configuration. Operando characterizations reveal that D/CoFc-MOF undergoes a unique stepwise activation during OER, progressing from pristine MOF state to intermediate α-FeOOH state, and ultimately to active CoFeOOH phase, which markedly differs from conventional single-step surface phase conversion. Theoretical calculations demonstrate that the electronic interaction between the active Co sites and OOH* intermediates of MOF-derived defective CoFeOOH can be effectively strengthened, thereby overcoming the high reaction barrier and enhancing OER activity. The D/CoFc-MOF anode, deployed in anion exchange membrane water electrolysis, achieves industrial-scale current densities of 1 A cm −2 at 1.69 V and operates stably for 300 h. This approach provides a fundamental insight into designing catalysts prone to dynamic phase transitions.}, archive = {J_ANGEW}, author = {Jian Zhou and Shuai Qiu and Xianbiao Hou and Tengjia Ni and Canhui Zhang and Shuixing Dai and Xingkun Wang and Guanghui Wang and Heqing Jiang and Minghua Huang}, doi = {10.1002/anie.202503787}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503787}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Defect-driven stepwise activation of Metal–Organic frameworks toward industrial-level anion exchange membrane water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Separation of MnWOx and NaWSiOx phases boosts oxidative coupling of methane. ANGEW, 64(29), e202503767. (www)

  @article{ , abstract = {The oxidative coupling of methane (OCM) is an attractive approach for methane transformations, but achieving a satisfactory combination of activity and selectivity remains challenging, even with the promising Mn–Na 2 WO 4 /SiO 2 catalyst. Herein, we demonstrate that nanoscale separation of Mn-based and Na 2 WO 4 -based phases results in a highly efficient catalyst, achieving a remarkable 79% selectivity for C 2 –C 3 hydrocarbons at a 32% CH 4 conversion at 775 °C, outperforming most previously reported catalysts. Our studies reveal that MnWO x phases with adjustable surface Mn/W ratios and redox activities are more effective for the selective activation of O 2 , thereby enhancing the OCM of CH 4 . The assembly of MnWO x and Na 2 WO 4 /SiO 2 components in nanoscale proximity significantly promotes the formation of C 2 –C 3 hydrocarbons by suppressing deep oxidation. We propose a bifunctional mechanism involving the transfer of active oxygen species from MnWO x to Na 2 WO 4 /SiO 2 , which induces selective activation and coupling of CH 4 on the Na 2 WO 4 /SiO 2 surface.}, archive = {J_ANGEW}, author = {Yu Xie and Jiawei Cheng and Wangyang Wang and Yaoyao Han and Qiyuan Fan and Hui Li and Kang Cheng and Qinghong Zhang and Ye Wang}, doi = {10.1002/anie.202503767}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503767}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Separation of MnWOx and NaWSiOx phases boosts oxidative coupling of methane}, volume = {64}, year = {2025}, }
• (2025). Charge relocation enables a modular and diastereoselective synthesis of cis-substituted tetrahydrofurans. ANGEW, 64(29), e202503750. (www)

  @article{ , abstract = {Diastereoselective construction of organic scaffolds from simple and commercial materials is a powerful strategy in contemporary organic synthesis. Herein, we report a novel disconnection for the direct preparation of tetrahydrofurans (THFs) and corresponding derivatives from acyl chlorides and alkenes using charge relocation. Newly synthesised Hantzsch ester derivatives, functioning both as hydride sources and selectivity modulators, enabled exceptional diastereoselectivity. The wide range of alkenes tolerated is a highlight of the method, enabling the construction of structurally distinct THF-containing skeletons.}, archive = {J_ANGEW}, author = {Zhi-Jie Niu and Bogdan R. Brutiu and Margaux Riomet and Daniel Kaiser and Nuno Maulide}, doi = {10.1002/anie.202503750}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503750}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Charge relocation enables a modular and diastereoselective synthesis of cis-substituted tetrahydrofurans}, volume = {64}, year = {2025}, }
• (2025). Vanadia nanozymes inhibit platelet aggregation, modulate signaling pathways and prevent pulmonary embolism in mice. ANGEW, 64(29), e202503737. (www)

  @article{ , abstract = {Thrombosis is a pathological condition which represents the formation of clots inside blood vessels, blocking the flow of blood through the circulatory system. A high occurrence of thrombotic events, particularly deep vein thrombosis and pulmonary embolism, has been observed in COVID-19 patients. Platelets (thrombocytes), the small cell fragments in the blood, play crucial roles in vascular haemostasis and thrombosis. The activation and subsequent aggregation of platelets lead to the formation of thrombus, a key process in the development of cardiovascular diseases. Therefore, inhibitors of platelet aggregation are important for the prevention and treatment of many thrombotic disorders. As the selenoenzyme glutathione peroxidase (GPx) is known to prevent platelet-dependent thrombosis, we have studied a series of antioxidant nanozymes for their ability to inhibit platelet activation/aggregation. Herein, we show that V 2 O 5 nanozymes with specific and morphology-dependent GPx activity effectively inhibit the aggregation of human platelets and prevent pulmonary thromboembolism in mice. Crucially, the nanozymes do not lead to the unwanted side effect of bleeding, which is important in the development of more effective and safe antithrombotic agents.}, archive = {J_ANGEW}, author = {G. R. Sherin and Bidare N. SharathBabu and Kurnegala Manikanta and Kesturu S. Girish and Govindasamy Mugesh}, doi = {10.1002/anie.202503737}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503737}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vanadia nanozymes inhibit platelet aggregation, modulate signaling pathways and prevent pulmonary embolism in mice}, volume = {64}, year = {2025}, }
• (2025). Wide temperature 500 wh kg−1 lithium metal pouch cells. ANGEW, 64(29), e202503693. (www)

  @article{ , abstract = {The performance of lithium metal batteries is significantly affected by temperature variations, which makes it challenging for them to operate across a wide temperature range. Herein, a wide temperature adaption electrolyte is proposed, enabling excellent electrochemical performance of lithium metal batteries from −40 °C to 60 °C. Large, 5.8 Ah pouch cells employing such an electrolyte achieve high energy density of 503.3 Wh kg −1 at 25 °C with a lifespan of 260 cycles and outstanding energy density of 339 Wh kg −1 at −40 °C. The critical role of the solid electrolyte interphase (SEI) in determining the temperature-dependent performance of lithium metal batteries is unveiled. It is demonstrated that the LiF-rich, anion-derived SEI facilitates Li + diffusion in SEI. Moreover, accelerated Li + desolvation at SEI is observed. These two aspects promote the kinetics of lithium metal anodes and further inhibit the dendrite growth at low temperatures. This work showcases the importance of understating the chemistry of SEI to enable wide temperature lithium metal batteries.}, archive = {J_ANGEW}, author = {Zichun Xiao and Xu Liu and Feng Hai and Yong Li and Duzhao Han and Xiangwen Gao and Zhenxin Huang and Yu Liu and Zhen Li and Wei Tang and Yuping Wu and Stefano Passerini}, doi = {10.1002/anie.202503693}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503693}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Wide temperature 500 wh kg−1 lithium metal pouch cells}, volume = {64}, year = {2025}, }
• (2025). Bridging nano to micron: Architectural engineering of supramolecular bottlebrushes for extensively tunable structures and photonics. ANGEW, 64(29), e202503633. (www)

  @article{ , abstract = {Supramolecular bottlebrush block copolymers (BBCPs) offer greater architectural adaptability than covalent BBCPs. However, the dynamic nature of non-covalent interactions hinders precise control over their chain architecture, resulting in poorly controlled self-assembly, unpredictable morphologies, and limited utility. Herein, we introduce a novel molecular design for amphiphilic supramolecular BBCPs that overcomes key challenges in the field. The resulting materials exhibit superior thermodynamic stability in weakly polar solvents. This enables the first demonstration of well-controlled self-assembly of supramolecular surfactants within a complex emulsion system, leading to the formation of photonic supraballs with homogenous porous structures. Critically, precise chain architectural engineering enables pore diameter tuning over an unprecedented nanometer-to-micrometer range (67 nm–1.92 µm), significantly surpassing the maximum domain sizes achievable with self-assembled covalent BBCPs. This extends the photonic bandgap into the mid-wave infrared range, paving the way for next-generation materials with potential applications in thermal management.}, archive = {J_ANGEW}, author = {Dezhi Liu and Zhenli Zhang and Yuxia Zhang and Yuesheng Li and Dong-Po Song}, doi = {10.1002/anie.202503633}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503633}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bridging nano to micron: Architectural engineering of supramolecular bottlebrushes for extensively tunable structures and photonics}, volume = {64}, year = {2025}, }
• (2025). Synthesis of molecular organo-f-element-polyphosphides with nonclassical divalent lanthanide precursors. ANGEW, 64(29), e202503403. (www)

  @article{ , abstract = {The coordination and functionalization of white phosphorus (P 4 ) by transition metal and main group element compounds have led to a great variety of polyphosphides. However, larger polyphosphides of the rare-earth elements are elusive. In this study, we report the synthesis and full characterization of the largest polyphosphides of the f-elements, [K(18-crown-6)] 2 [(Cp′′ 2 Ln) 2 ( μ 4 - ƞ 2 : ƞ 2 : ƞ 2 : ƞ 2 P 14 )], which was isolated along with [K(18-crown-6)][(Cp′′ 2 Ln) 2 ( μ - ƞ 3 : ƞ 3 P 3 )] (Ln = La, Ce, Cp′′ = 1,3-bis(trimethylsilyl)cyclopentadienyl). These compounds were obtained by using nonclassical divalent compounds of the early lanthanides for the reduction of white phosphorus.}, archive = {J_ANGEW}, author = {David Frick and Elena Pross and Ralf Köppe and Peter W. Roesky}, doi = {10.1002/anie.202503403}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503403}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of molecular organo-f-element-polyphosphides with nonclassical divalent lanthanide precursors}, volume = {64}, year = {2025}, }
• (2025). Hyperstable, minimal-length, and blunt-ended collagen heterotrimers. ANGEW, 64(29), e202503353. (www)

  @article{ , abstract = {Most natural collagens are heterotrimers—triple helices formed from three non-identical peptide strands. The design of synthetic heterotrimeric collagen is challenging since a mixture of three different peptides can form as many as 27 unique triple helices. Here, we present a general method for the assembly of collagen heterotrimers with a wide range of lengths, thermal stabilities, and strand arrangements driven by complementary interstrand salt bridges between (2 S ,4 S )-4-aminoproline and aspartate residues. We show how kinetic trapping of undesired trimers can be overcome by adjusting the annealing conditions to obtain the target heterotrimeric helix selectively under thermodynamic control. The design rules and annealing methods allowed the creation of the most stable supramolecular heterotrimer (32 residues, T m = 76 °C) and the shortest stable heterotrimer (17 residues, T m = 19 °C) to date. Furthermore, frame-shifting enabled, for the first time, the creation of a collagen triple helix with blunt ends.}, archive = {J_ANGEW}, author = {Tomas Fiala and Philipp Bittner and Rahel Heeb and Valdrin Islami and Carolina Söll and Adam Pruška and Renato Zenobi and Helma Wennemers}, doi = {10.1002/anie.202503353}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hyperstable, minimal-length, and blunt-ended collagen heterotrimers}, volume = {64}, year = {2025}, }
• (2025). A dynamic self-healing protective layer enabling stable zinc ion batteries through strong zn-S affinity and intramolecular hydrogen bonding. ANGEW, 64(29), e202503345. (www)

  @article{ , abstract = {Aqueous Zn-ion batteries (AZIBs) are promising for large-scale energy storage, yet Zn metal anodes face issues like hydrogen evolution, dendrite growth, and corrosion. Herein, we develop a self-healable, adhesive polymer layer for AZIBs by polymerizing thioctic acid (TA) on Zn surfaces. Thanks to the strong and spontaneous affinity between Zn metal surface and S atoms on polymer chains, this protective layer can firmly and dynamically adhere to the Zn surface. Thus, even at a thickness of <1 µm, the protective layer exhibits a strong adhesion force of up to 10.5 N with Zn surface, while the abundant carboxyl groups in the protective layer can form intramolecular hydrogen bonds, endowing its high self-healing property and enhancing its strength (Young's modulus reaches 15.1 GPa). Such a protective layer effectively inhibits the dendrite growth physically and regulates the Zn 2+ migration and deposition behavior chemically. Therefore, the symmetric cells can be cycled for more than 1000 h at the current densities of 1.0 and 5.0 mA cm −2 , respectively. Full cells with NH4V4O10 also run stably for 1000 cycles with a high capacity retention. This work offers a promising strategy for designing multifunctional polymer coating towards high-stability and long-cycling AZIBs.}, archive = {J_ANGEW}, author = {Bao Li and Bo Zhang and Xiang Bai and Jiahui Zhang and Xinyue Chang and Lifeng Hou and Hao Huang and Tiantian Lu and Shi Wang and Zhong Jin and Qian Wang}, doi = {10.1002/anie.202503345}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503345}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A dynamic self-healing protective layer enabling stable zinc ion batteries through strong zn-S affinity and intramolecular hydrogen bonding}, volume = {64}, year = {2025}, }
• (2025). A cerium-naphthazarin catecholate MOF as a heterogeneous photocatalyst for selective functionalization of alkanes. ANGEW, 64(29), e202503328. (www)

  @article{ , abstract = {In this work, we have successfully synthesized a series of novel semiconducting 2D catecholate metal-organic frameworks (MOFs) based on naphthazarin ligands by utilizing unraveled metal-acetyl acetonate linkage chemistry. The synthesized MOFs exhibited excellent light absorption properties and chemical stability across various solvents. Its insoluble and stable framework, combined with an optimal band gap, enabled its use as a photocatalyst for organic transformations. For the first time, Ce-Naph MOF is explored as a heterogeneous catalyst for photocatalytic applications specifically for the selective C–H amination of alkanes, achieving yields of up to 89% under ambient conditions. We propose that the initial metal-to-ligand charge transfer in Ce-Naph MOF, promoted by light, is essential for forming an active alkoxy-Ce(IV)-species. This species subsequently undergoes ligand-to-metal charge transfer to generate the alkoxy radical, which acts as a hydrogen atom transfer reagent to activate alkanes. Furthermore, Ce-Naph MOF demonstrated long-term cyclic stability, maintaining its catalytic activity and structural integrity over five cycles, highlighting its durability as a heterogeneous catalyst. We are confident that this straightforward and practical methodology opens new avenues for industrial applications, significantly advancing the fields of metal catalysis, photocatalysis, and sustainable chemistry.}, archive = {J_ANGEW}, author = {Sharath Kandambeth and Rajesh Kancherla and Kuntal Pal and Taslim Melliti and Mostafa Zeama and Vinayak S. Kale and Issatay Nadinov and Abdulaziz M. Alali and Osama Shekhah and Omar F. Mohammed and Magnus Rueping and Mohamed Eddaoudi}, doi = {10.1002/anie.202503328}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503328}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A cerium-naphthazarin catecholate MOF as a heterogeneous photocatalyst for selective functionalization of alkanes}, volume = {64}, year = {2025}, }
• (2025). Mitigating molecular aggregation in drug discovery with predictive insights from explainable AI. ANGEW, 64(29), e202503259. (www)

  @article{ , abstract = {Herein, we present the application of multi-channel graph attention network (MEGAN), our explainable AI (xAI) model, for the identification of small colloidally aggregating molecules (SCAMs). This work offers solutions to the long-standing problem of false positives caused by SCAMs in high-throughput screening for drug discovery and demonstrates the power of xAI in the classification of molecular properties that are not chemically intuitive based on our current understanding. We leverage xAI insights and molecular counterfactuals to design alternatives to problematic compounds in drug screening libraries. Additionally, we experimentally validate the MEGAN prediction classification for one of the counterfactuals and demonstrate the utility of counterfactuals for altering the aggregation properties of a compound through minor structural modifications. The integration of this method in high-throughput screening approaches will help combat and circumvent false positives, providing better lead molecules more rapidly and thus accelerating drug discovery cycles.}, archive = {J_ANGEW}, author = {Hunter Sturm and Jonas Teufel and Kaitlin A. Isfeld and Pascal Friederich and Rebecca L. Davis}, doi = {10.1002/anie.202503259}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mitigating molecular aggregation in drug discovery with predictive insights from explainable AI}, volume = {64}, year = {2025}, }
• (2025). Probing the nonlinear chiroptical activity of multiturn aromatic helices using linearly polarized light. ANGEW, 64(29), e202503025. (www)

  @article{ , abstract = {Four quinoline-based oligoamide foldamers of varying lengths, from 6 to 28 Å, were synthesized in both of their enantiomeric forms, exhibiting between 1.6 and 6 helical turns. The helically chiral structures were analyzed using hyper-Rayleigh scattering (HRS) in solution to evaluate their chiroptical nonlinear activity in second-harmonic generation, exclusively employing linear polarization of the incident light. To achieve this, we completely overhauled our homemade equipment setup. By applying a nonlinear chiroptical model developed by us, we were able to distinguish between the achiral and chiral contributions to the nonlinear response of the samples. Surprisingly, the effect of helix elongation on the chiral response, as monitored by HRS, exhibited a nonmonotonic trend, which contrasts with the behavior observed with classical linear optical techniques. A detailed investigation revealed that the number of helical turns in the foldamers governs the magnitude of the nonlinear optical (NLO) response, exhibiting a periodic evolution rather than a linear increase with length.}, archive = {J_ANGEW}, author = {Rita Borges-Anastácio and Eric Merlet and Frédéric Adamietz and Brice Kauffmann and Yann Ferrand and Céline Olivier and Vincent Rodriguez}, doi = {10.1002/anie.202503025}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202503025}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing the nonlinear chiroptical activity of multiturn aromatic helices using linearly polarized light}, volume = {64}, year = {2025}, }
• (2025). Insight into lysine selection via controlled degradation of 2,4-diaminobutyric acid and ornithine polypeptides. ANGEW, 64(29), e202502629. (www)

  @article{ , abstract = {The selection of twenty canonical amino acids in protein synthesis is well-established, yet the reasons behind their natural selection remain unclear. Specifically, why structurally similar analogs, such as L -2,4-diaminobutyric acid (Dab) and L -ornithine (Orn), are not chosen over L -lysine (Lys) is unknown. These analogs differ only in alkyl chain length, raising the question of whether such variations influence polypeptide stability and natural selection. To investigate how unnatural amino acids affect the stability of synthesized polypeptides, we present the efficient synthesis of o -nitrobenzyl (NB) carbamate-caged photo-responsive polypeptide amphiphiles based on Dab and Orn via polymerization of N -phenoxycarbonyl-functionalized amino acid precursors. Depending on the self-assembly methods, these poly(ethylene glycol) (PEG)- b -polypeptide hybrid block copolymers formed various nanostructures, including two-dimensional discs and oblate vesicles. Upon photoirradiation, the newly liberated primary amines underwent spontaneous cyclization with backbone amide linkages to generate thermodynamically stable 5- or 6-membered lactams. Such a backbone degradation process eventually led to the disassembly and disintegration of the assemblies. These findings provide new insights into the natural selection of Lys, and open new possibilities for creating functional polypeptide-based materials in drug delivery, tissue engineering, and other biomedical applications.}, archive = {J_ANGEW}, author = {Mingxuan Hou and Wenjin Li and Jie Cen and Wenhao Pan and Zhengyu Deng and Jinming Hu and Shiyong Liu}, doi = {10.1002/anie.202502629}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202502629}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insight into lysine selection via controlled degradation of 2,4-diaminobutyric acid and ornithine polypeptides}, volume = {64}, year = {2025}, }
• (2025). Precise control of active site configurations in high-entropy intermetallic compounds for electrocatalytic nitrate reduction to ammonia. ANGEW, 64(29), e202502333. (www)

  @article{ , abstract = {High-entropy alloys (HEAs), composed of five or more elements in similar proportions, exhibit unique physicochemical properties, but their disordered atomic structures pose challenges in the precise control of active sites. In contrast, high-entropy intermetallic compounds (HEIs), with an ordered atomic arrangement and well-defined atomic positions, provide clear active site configurations, making them particularly advantageous for complex electrocatalytic reactions like the nitrate reduction reaction (NO 3 RR). Herein, we present the FeCoNiGeSb-HEI with precisely controlled elemental distributions, leading to the formation of distinct active sites. The FeCoNiGeSb-HEI catalyst exhibits high activity for NO 3 RR, achieving a high NH 3 yield rate of 7.5 mg h −1 cm −2 at −0.4 V and a faradaic efficiency (FE) of 97.6% at −0.30 V, along with excellent stability. Density functional theory (DFT) calculations and experimental results reveal that Co sites act as key active sites, whereas Fe and Ni atoms contribute a synergistic effect. Additionally, the FeCoNiGeSb-HEI catalyst functions in a bifunctional system coupling NH 3 production with the glycerol oxidation reaction (GOR), achieving an NH 3 yield of 9.8 mg h −1 cm −2 at 1.8 V, maintaining stable performance for 100 h.}, archive = {J_ANGEW}, author = {Xiao Ma and Chaoqun Ma and Yi-Chi Wang and Jing Xia and Sumei Han and Huaifang Zhang and Caihong He and Fukai Feng and Gang Lin and Wenbin Cao and Lin Gu and Xiangmin Meng and Lijie Zhu and An-Liang Wang and Haiqing Yin and Qipeng Lu}, doi = {10.1002/anie.202502333}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202502333}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise control of active site configurations in high-entropy intermetallic compounds for electrocatalytic nitrate reduction to ammonia}, volume = {64}, year = {2025}, }
• (2025). Spatiotemporal super-resolution imaging of lipid metabolism dynamics in Physiological/Pathological conditions. ANGEW, 64(29), e202502159. (www)

  @article{ , abstract = {Dysregulated lipid metabolism plays a critical role in the pathogenesis of numerous diseases. However, due to the lack of effective solutions, the dynamic monitoring and deep understanding of lipid metabolism in those disease progression has remained challenging. Herein, a polarity-sensitive, lipid droplets (LDs)-targeted probe was developed for spatiotemporal super-resolution imaging of lipid metabolism dynamics. Based on the stimulated emission depletion (STED) and fluorescence lifetime imaging microscopy (FLIM) platform, we achieved the super-resolution visualization and dynamic tracking of the nonlinear fusion and expansion mechanisms of LDs in orthotopic pathology models—an unprecedented achievement in the field. We also analyzed lipid distribution in zebrafish models using the STED-FLIM platform to capture lipid metabolism at the organismal level. Crucially, based on the integrated STED-FLIM platform, this probe accurately monitors lipid metabolism in cellular and pathological tissue contexts of atherosclerosis and fatty liver. This breakthrough provides novel insights for diagnosing lipid metabolism-related diseases and advancing therapeutic development.}, archive = {J_ANGEW}, author = {Shixian Cao and Qihang Ding and Caixia Sun and Borbala Codogno and Zhiqiang Liu and Xiaoqiang Yu and Jong Seung Kim and Kang-Nan Wang}, doi = {10.1002/anie.202502159}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202502159}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatiotemporal super-resolution imaging of lipid metabolism dynamics in Physiological/Pathological conditions}, volume = {64}, year = {2025}, }
• (2025). An organic-inorganic-integrated solid electrolyte interphase with high-resilience and anti-corrosion for sustainable zinc metal anode. ANGEW, 64(29), e202501702. (www)

  @article{ , abstract = {Aqueous zinc metal batteries (AZMBs) are highly regarded for their exceptional safety, low cost, environmental compatibility, and potential as a sustainable alternative to lithium-ion batteries. However, Zn dendrite growth and hydrogen evolution on anode side result in limited lifespan and safety issues. Herein, an organic-inorganic-integrated solid electrolyte interphase (SEI) was in situ formed by adding 4-(trifluoromethyl)-1H-imidazole (TFMI) as an electrolyte additive. The artificial SEI merited higher maximum elastic deformation energy due to relatively high resilience and toughness, which can prevent Zn dendrite penetration and anode self-cracking and pulverization. In addition, N-containing heterocycles in SEI act as a H + catcher, thereby inhibiting anode corrosion and hydrogen evolution. As a result, the Zn||Zn symmetric cell has delivered stable cycling performance after 1500 h at 5 mA cm −2 with a terminated capacity of 5 mAh cm −2 . And an outstanding coulombic efficiency of 99.46% at the 2200th cycle was achieved for a Cu||Zn asymmetric cell. Furthermore, a Zn||PANI full battery presented a stable cycling performance with a high-capacity retention of 97.6% after 200 cycles.}, archive = {J_ANGEW}, author = {Maoyu Peng and Zhenjie Liu and Machuan Hou and Ruochen Zhang and Min Cheng and Jiangtao Yu and Yang Feng and Peixin Jiao and Tongrui Zhang and Ziheng Zhang and Xi Chen and Zhe Hu and Kai Zhang}, doi = {10.1002/anie.202501702}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202501702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An organic-inorganic-integrated solid electrolyte interphase with high-resilience and anti-corrosion for sustainable zinc metal anode}, volume = {64}, year = {2025}, }
• (2025). Cl3Al-PH3 is a weak lewis pair allowing the synthesis of sterically highly hindered primary and secondary alkyl phosphanes. ANGEW, 64(29), e202501656. (www)

  @article{ , abstract = {Phosphane (PH 3 ) gas has the highest phosphorus content of all commercial phosphorus compounds, yet its use for valuable chemicals is very limited. Aluminum chloride and phosphane yield quantitatively the adduct Cl 3 Al-PH 3 , which is easy to handle and reacts with a large set of alkyl halides to give phosphonium salts that can be converted to primary phosphanes. This sequence has been generalized to access various secondary and some tertiary phosphanes in excellent yields under mild conditions and short reaction times. With unprecedented ease, these reactions allow, in particular, the preparation of sterically demanding phosphanes, which, as ligands, are key components of highly catalytically competent transition metal complexes.}, archive = {J_ANGEW}, author = {Jan Oswald and Csilla Fekete and Matt Baker and Mark Bispinghoff and Paul G. Pringle and Norbert Weferling and Zoltán Benkő and Hansjörg Grützmacher}, doi = {10.1002/anie.202501656}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202501656}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cl3Al-PH3 is a weak lewis pair allowing the synthesis of sterically highly hindered primary and secondary alkyl phosphanes}, volume = {64}, year = {2025}, }
• (2025). Atomically dispersed fe confined into MnO nanoclusters enhances alkaline oxygen reduction activity and stability. ANGEW, 64(29), e202501531. (www)

  @article{ , abstract = {Transition metal oxide electrocatalysts are promising alternatives to expensive noble metals for the oxygen reduction reaction (ORR). Here, we present a simple metal-atom localization strategy to confine the atomically dispersed Fe into MnO nanoclusters, which are dispersed and immobilized on high-conductivity carbon support (MF/CN). The experimental and theoretical calculation results reveal that the trace Fe(III) ions doped into MnO nanoclusters can induce charge transfer and spin state transition to trigger a butterfly effect, obtaining abundant active Mn(III) with single-electron e g configuration and strengthened built-in electric field (BIEF), which is greatly helpful to balance the adsorption and desorption of ORR O-containing intermediates, facilitate the interfacial electron transfer, and improve the electrical conductivity. As a result, the optimized MF 0.04 /CN exhibits compelling alkaline ORR activity (half-wave potential 0.79 V vs. RHE) and stability (nearly 100% current retention rate for 30 h). Finally, the MF 0.04 /CN realizes a remarkable power density (138 mW cm −2 ) and durability (>666 h at 10 mA cm −2 ) in Zn-air batteries. This finding not only helps to design high-performance metal oxide heterointerfaces by tuning e g orbital occupancy and BIEF strength, but also deepens the understanding of the reaction mechanism.}, archive = {J_ANGEW}, author = {Meng Dan and Xiting Zhang and Congyi Du and Zhen Guo and Jianan Zhang and Zhao-Qing Liu}, doi = {10.1002/anie.202501531}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202501531}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomically dispersed fe confined into MnO nanoclusters enhances alkaline oxygen reduction activity and stability}, volume = {64}, year = {2025}, }
• (2025). Engineering charge polarized au sites for low-temperature acetylene hydrochlorination. ANGEW, 64(29), e202501370. (www)

  @article{ , abstract = {Cationic gold catalyzed acetylene hydrochlorination represents a classical landmark in eliminating global mercury pollution, but their sustainable implementation is hindered by acetylene-dependence design criteria and high operating temperatures. Herein, a platform of carbon-supported single-atoms Au catalysts (Au/BC and Au/NC) with polarized charge characteristics are developed via engineering Au sites with hosted B, N configurations. The negatively charged Au/BC catalyst unlocks the low-temperature inactivity (413–423K) of the Au/NC catalyst while exhibiting superior catalytic performance in the 433–473K operating temperature range. We confirm that the classical scaling relationships on acetylene can be broken by narrowing the adsorption capacity between acetylene and HCl on Au δ⁻ sites via facilitating the back-donation of d electrons into the antibonding orbitals of acetylene. Prolonging the durability of Au catalysts is achieved through preceding an additional robust Au δ⁻ → Au δ⁺ cycle prior to the classic Au δ⁺ → Au 0 route. This work opens a promising avenue for low temperature vinyl chloride production.}, archive = {J_ANGEW}, author = {Chun Li and Ruoting Liu and Zilong Zhang and Fangmin Zuo and Tingting Jiang and Haifeng Zhang and Bolin Wang and Nieves López-Salas}, doi = {10.1002/anie.202501370}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202501370}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering charge polarized au sites for low-temperature acetylene hydrochlorination}, volume = {64}, year = {2025}, }
• (2025). Identifying the role of solvation entropy for the solvation chemistry in nonaqueous electrolytes. ANGEW, 64(29), e202501315. (www)

  @article{ , abstract = {Solvating power, a pivotal determinant of solvation structure, has been extensively studied in past few decades. However, extant descriptors such as donor number and binding energy, predominantly focus on solvation enthalpy, while ignoring crucial solvation entropy, which often leads to contradictory conclusions. Here, we surmount this issue by exploring the relationship between the solvation thermodynamics and solvating power. It is revealed that high solvation entropy of polydentate solvents (DME, DGDME, etc.) endows them with strong solvating power in spite of their low binding energy. Even for monodentate solvents, solvation entropy is also non-negligible. Thus, solvation free energy (Δ G ) is first proposed as a perfect descriptor of solvating power, which includes the effect of solvation entropy. Drawing on profound insights of solvation thermodynamics and solvating power, a database of Δ G Avg and permittivity of common solvents is established to provide pivotal inspirations for the design of solvation structure for next-generation advanced electrolytes.}, archive = {J_ANGEW}, author = {Kean Chen and Hui Chen and Zhenxu Zheng and Yuwen Liu and Yongjin Fang and Zhongxue Chen and Yuliang Cao}, doi = {10.1002/anie.202501315}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202501315}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identifying the role of solvation entropy for the solvation chemistry in nonaqueous electrolytes}, volume = {64}, year = {2025}, }
• (2025). Co-regulation of interface and bulk for enhanced localized high-concentration electrolytes in stable and practical zinc metal batteries. ANGEW, 64(29), e202501183. (www)

  @article{ , abstract = {Rechargeable zinc metal batteries (RZMBs) are promising for energy storage due to their high capacity and cost-effectiveness. However, their commercialization is hindered by challenges including dendrite growth, parasitic reactions, and cathode degradation, particularly under low current densities and negative/positive (N/P) capacity ratios. Localized high-concentration electrolytes offer potential solutions, but their reliance on high salt concentrations to replicate solvation structures of high-concentration electrolytes limits their practicality, due to diluent's inherent inertness that limits its role in interfacial chemistry. Here, we present a co-regulation strategy that integrates bulk and interfacial properties to develop an interfacial-enhanced localized high-concentration electrolyte (ILHCE). By incorporating non-coordinating 1,4-dioxane diluent and 1-ethyl-3-methylimidazolium (emim + ) cations into dilute aqueous electrolytes, dioxane molecules are pulled into electric double layer (EDL) through the interaction between emim + and dioxane, achieving a pronounced dilution effect from bulk electrolyte to the EDL. This generates an anion-rich and water-depleted EDL at both anode and cathode interfaces, enhancing Zn 2+ transport dynamics, ensuring cathode stability and deriving a robust anion-derived solid-electrolyte interphase. Full batteries using Mn 0.5 V 6 O 13 cathodes with a low N/P ratio of 1.77 demonstrate 80% capacity retention over 300 cycles at 0.2 A g −1 , highlighting ILHCE as a transformative electrolyte design toward real-world applications.}, archive = {J_ANGEW}, author = {Tao Li and Hange Yang and Xinji Dong and Hexian Ma and Jinghua Cai and Chenyu Wei and Tao Zhang and Shicong Zhang and Fuqiang Huang and Tianquan Lin}, doi = {10.1002/anie.202501183}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202501183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Co-regulation of interface and bulk for enhanced localized high-concentration electrolytes in stable and practical zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Hyperbranched polymer-based multipath proton transmembrane transport system with redox-switchable characteristics for cancer cell apoptosis. ANGEW, 64(29), e202500986. (www)

  @article{ , abstract = {Natural channel proteins (NCPs) enable efficient and selective transport of specific species across cellular membranes and exhibit stimulus-responsive behaviors; however, replicating these features in their artificial counterparts poses significant challenges. Here, we report a hyperbranched polymer (HBP)-derived biomimetic multipath proton transport system, H3 , by a straightforward “one-pot” cationic polymerization of 3-ethyl-3-(hydroxymethyl)-oxetane. H3 efficiently transports protons while rejecting other ions and water molecules by forming multiple hydrogen bonding chains like natural proton channels. Patch clamp experiments revealed that H3 facilitates rapid proton transport ( γ H+ = 181 ± 4 pS) comparable to that of natural gramicidin A ( γ H+ = 213 ± 4 pS) and demonstrates high H + -selectivity, with P H+ / P K+ , P H+ / P Na+ , and P H+ / P Cl- values reaching 78.4, 233.2, and 167.8, respectively. H3 -induced proton transport causes elevated lysosomal pH and mitochondrial damage, ultimately resulting in severe cancer cell apoptosis (IC 50 : 0.23 µM for U87MG; 1.04 µM for B16F10). Interestingly, selenide moieties-containing H3-Se exhibits an unprecedented in situ redox-switchable “ON–OFF” of proton transport by regulating its hydrophilicity. This work will contribute to a deeper understanding of the intrinsic mechanisms of NCPs and treatments for cancer and other diseases.}, archive = {J_ANGEW}, author = {Cong Li and Yaqi Wu and Sheng Bao and Zhengwei Xu and Jing Yan and Hui Li and Xiaoxuan Yu and Zihui Weng and Jiayun Xu and Tingting Wang and Yongfeng Zhou and Tengfei Yan and Yi Yan and Junqiu Liu}, doi = {10.1002/anie.202500986}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202500986}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hyperbranched polymer-based multipath proton transmembrane transport system with redox-switchable characteristics for cancer cell apoptosis}, volume = {64}, year = {2025}, }
• (2025). Ultrahigh-affinity molecular recognition in water and biomedical applications. ANGEW, 64(29), e202500916. (www)

  @article{ , abstract = {Aqueous-phase molecular recognition pairs with ultrahigh binding affinity hold immense value in biotechnology and chemical applications. However, the rational design of synthetic pairs with such exceptional binding strength has long remained a significant challenge, with notable progress achieved only in recent years. In this minireview, we begin by defining the term “ultrahigh-affinity” through a comprehensive analysis of available data on aqueous-phase molecular recognition by water-soluble macrocyclic hosts. Based on this foundation, we provide a detailed overview of the latest advancements in various classes of ultrahigh-affinity receptors, extracting key design principles that drive their remarkable performance. We further highlight emerging applications of ultrahigh-affinity molecular pairs in biomedical materials, spanning bioorthogonal chemistry, biosensing, bioimaging, drug delivery, and toxin sequestration. These examples underscore the transformative potential of ultrahigh-affinity recognition in addressing real-world biomedical challenges. Finally, we offer a forward-looking perspective on the future of this rapidly evolving field, exploring potential directions for designing more diverse and functional ultrahigh-affinity molecular recognition tools. By bridging the gap between fundamental science and practical applications, this minireview aims to inspire the development of next-generation molecular recognition systems and foster deeper integration between supramolecular chemistry and biomedical materials, paving the way for innovative solutions to pressing biomedical needs.}, archive = {J_ANGEW}, author = {Fang-Yuan Chen and Rong Fu and Zhihao Gong and Chunju Li and Dong-Sheng Guo and Kang Cai}, doi = {10.1002/anie.202500916}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202500916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrahigh-affinity molecular recognition in water and biomedical applications}, volume = {64}, year = {2025}, }
• (2025). A core-shell structured argyrodite-type electrolyte enabling elevated Chemical/Electrochemical stability. ANGEW, 64(29), e202500388. (www)

  @article{ , abstract = {Sulfide solid electrolytes hold great promise in all-solid-state batteries owing to high ionic conductivity and good formability. However, their poor chemical/electrochemical stability imposes limitations on further large-scale application. In this study, a versatile solid electrolyte (SE) is finely crafted with the core of Cl-gradient argyrodite structure and the shell of LiCl layer. Leveraging LiCl shell as a “reservoir”, this argyrodite SE preserves the structure integrity and good Li + conduction upon air exposure, exhibiting remarkable chemical stability. Moreover, Li + transport from argyrodite bulk and grain boundary is synergistically enhanced through the specific surface engineering strategy, resulting in an exceptionally high ionic conductivity of 10.62 mS cm −1 . The LiCl shell, characterized by favorable electron shielding and lithiophobicity, enables the core-shell argyrodite with impressive electrochemical stability over a wide voltage range (0–5 V versus Li/Li + ) and good match for Li metal. As the electrode/electrolyte interface compatibility is optimized by engineering LiCl layer on SE, LiCoO 2 cathode paired with the modified SE retains a remarkable capacity retention of 95.6% over 500 cycles at 1 C.}, archive = {J_ANGEW}, author = {Shijie Lu and Yuxiang Zhang and Haijian Lv and Xinyu Zhang and Tianwen Yang and Zihan Li and Ming Ma and Xinyue Xu and Daobin Mu}, doi = {10.1002/anie.202500388}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202500388}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A core-shell structured argyrodite-type electrolyte enabling elevated Chemical/Electrochemical stability}, volume = {64}, year = {2025}, }
• (2025). Z-selective alkyne semireduction by an organic photoreductant. ANGEW, 64(29), e202425514. (www)

  @article{ , abstract = {The semireduction of alkynes is an indispensable transformation for the synthesis of Z -alkenes. Although extensive studies with mostly transition metal-based catalysts have enabled it to produce a broad scope of alkenes, a SciFinder TM search and a robustness screen of Lindlar's catalyst indicate that highly Lewis-basic nitrogen- and sulfur-containing motifs, which are prevalent in drugs, remain problematic. Herein, we report an alkyne semi-reduction using an organic photoreductant that tolerates all 10 of the most common Lewis-basic motifs in drugs. The reaction reduces terminal alkyl and aryl, dialkyl, alkyl aryl, and diaryl alkynes in high yields and Z- selectivities, while tolerating other reducible motifs like sulfones, nitriles, ketones, and electron-poor arenes. Ultraviolet/visible (UV/Vis) and nuclear magnetic resonance (NMR) titration studies indicate that the reaction occurs by formation of a photoexcitable electron donor-acceptor (EDA) complex. Furthermore, a time study indicated that the reductant enforces a Z -selective reaction, which is unusual for alkyne reductions via electron transfer.}, archive = {J_ANGEW}, author = {Benjamin R. G. Bissinger and Dang H. Vu and Henric F. Janning and Mario P. Wiesenfeldt}, doi = {10.1002/anie.202425514}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202425514}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Z-selective alkyne semireduction by an organic photoreductant}, volume = {64}, year = {2025}, }
• (2025). Self-optimizing cobalt tungsten oxide electrocatalysts toward enhanced oxygen evolution in alkaline media. ANGEW, 64(29), e202424074. (www)

  @article{ , abstract = {Self-optimizing mixed metal oxides represent a novel class of electrocatalysts for the advanced oxygen evolution reaction (OER). Here, we report self-assembled cobalt tungsten oxide nanostructures on a lab-synthesized copper oxide substrate through a single-step deposition approach. The resulting composite exhibits remarkable self-optimization behavior, shown by significantly reduced overpotentials and enhanced current densities, accompanied with substantial increase in OER kinetics, electrocatalytically active surface area, surface wettability, and electrical conductivity. Under operating conditions, interfacial restructuring of the electrocatalyst reveals the in situ formation of oxidized cobalt species as the true active site. Complementary density functional theory (DFT) calculations further demonstrate the formation of *OOH intermediate as the rate-determining step of OER, and highlight the adaptive binding of oxygen intermediates, which transitions from tungsten to cobalt site during OER process. Our study provides a fundamental understanding of the self-optimization mechanism and advances the knowledge-driven design of efficient water-splitting electrocatalysts.}, archive = {J_ANGEW}, author = {Christean Nickel and David Leander Troglauer and Zsolt Dallos and Dhouha Abid and Kevin Sowa and Magdalena Ola Cichocka and Ute Kolb and Boris Mashtakov and Bahareh Feizi Mohazzab and Shikang Han and Leon Prädel and Lijie Ci and Deping Li and Xiaohang Lin and Minghao Hua and Rongji Liu and Dandan Gao}, doi = {10.1002/anie.202424074}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202424074}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-optimizing cobalt tungsten oxide electrocatalysts toward enhanced oxygen evolution in alkaline media}, volume = {64}, year = {2025}, }
• (2025). Photochemical conversion of indazoles into benzimidazoles. ANGEW, 64(29), e202423804. (www)

  @article{ , abstract = {Fragment-based drug discovery relies on preparing diverse libraries of advanced building blocks, often incorporating heteroaromatic motifs. Altering the core of heteroaromatics to maximize library diversity typically requires de novo synthesis of each system. This can be often challenging when specific substitution patterns are needed. Here, we introduce a photochemical strategy for the direct permutation of 1 H - and 2 H -indazoles into benzimidazoles. This transformation exploits the distinct photochemical properties of these heteroaromatics and proceeds under mild conditions. Through systematic experimental and computational studies, we have elucidated a two-step mechanism involving excited-state tautomerization of 1 H -indazoles, followed by photochemical rearrangement of the resulting 2 H -isomers. This approach demonstrates broad substrate scope, high yields, and compatibility with a variety of functional groups. This method can expand the structural diversity of heterocycle-based libraries through the concept of chemical permutation for heteroaromatic interconversion.}, archive = {J_ANGEW}, author = {Thiago dos Santos and Cornelia S. Buettner and Dilara Berna Yildiz and Martina Mamone and Alessandro Ruffoni and Daniele Leonori}, doi = {10.1002/anie.202423804}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202423804}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photochemical conversion of indazoles into benzimidazoles}, volume = {64}, year = {2025}, }
• (2025). Remote control of eukaryotic gene expression by a modular ultrasound-responsive RNA toolkit. ANGEW, 64(29), e202421803. (www)

  @article{ , abstract = {Achieving remote control of biological processes remains a significant challenge in genetics. Although ultrasound has been employed to remotely regulate biological functions by targeting mechanosensitive ion channels, existing systems are constrained by the limited responsiveness of specific channels to specific ultrasound frequencies and their applicability to only a few cell types. Sonogenetics has shown promise for promoter control, thereby regulating gene transcription in eukaryotes. Here, we introduce a new modular toolkit for regulating gene expression using ultrasound-responsive RNA carriers capable of releasing small molecule modulators in response to a broad spectrum of ultrasound frequencies. The cells contain engineered mRNA structures encoding riboswitches or aptazymes, which respond specifically to these small molecule modulators finally controlling downstream protein expression by biocompatible ultrasound. This toolkit is versatile, functioning across various eukaryotic systems—from yeast to mammalian cells—and offers control over gene expression by regulating mRNA translation. We demonstrated that this sonogenetic toolkit robustly modulates gene expression, achieving up to a six-fold downregulation of protein levels in response to ultrasound stimulation. By expanding the application of sonogenetics across eukaryotes, this RNA-based toolkit might provide a promising platform for remotely controlling protein function in specific tissues through on-demand ultrasound activation in the future.}, archive = {J_ANGEW}, author = {Fahimeh Charbgoo and Aman Ishaqat and Junlin Chen and Fabian Wiertz and Adrian Kuzmanović and Matthias Bartneck and Fabian Kiessling and Andreas Herrmann}, doi = {10.1002/anie.202421803}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202421803}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote control of eukaryotic gene expression by a modular ultrasound-responsive RNA toolkit}, volume = {64}, year = {2025}, }
• (2025). An oxidative stress nanoamplifier to enhance the efficacy of cisplatin in head and neck cancer. ANGEW, 64(29), e202421481. (www)

  @article{ , abstract = {Cisplatin (CP) is a first-line platinum-based drug used for the treatment of head and neck cancer. However, tumor cells can diminish the therapeutic effects of CP through the detoxification system mediated by glutathione (GSH) and the nucleotide excision repair (NER) pathway. Herein, we present a light-activable and pH-responsive oxidative stress nanoamplifier (FPLC@IR OSNA), comprising an amphiphilic compound (FPLC) with Fmoc-lysine acting as a connector between a nitroimidazole derivative and a pH-responsive cinnamaldehyde (CA) derivative, loaded with photosensitizer IR780. The acidic microenvironment of the lysosome can trigger the release of CA to produce H 2 O 2 , which breaks down into oxygen, further improving the phototherapy efficacy mediated by IR780 irradiation. The consumption of oxygen during the phototherapy process induces hypoxia, prompting the reduction of nitroimidazole to aminoimidazole and leading to reduced GSH synthesis, enhancing tumor cell death induced by CP. Meanwhile, the accumulation of intracellular reactive oxygen species (ROS) during phototherapy attenuates the nuclear NER pathway, further augmenting the therapy effect of CP. This strategy, by combining FPLC@IR OSNA with laser and CP, significantly promotes the therapeutic effect in vitro and notably inhibits tumor growth in both Cal27 cell line-derived xenograft models and patient-derived xenograft models.}, archive = {J_ANGEW}, author = {Zhenzhen Li and Qiaolin Liu and Guorong Wang and Ru Bai and Shengmin Li and Tao Liu and Qingzhen Wang and Yufeng Peng and Fei Teng and Huige Zhou and Junfang Xian and Chunying Chen}, doi = {10.1002/anie.202421481}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202421481}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An oxidative stress nanoamplifier to enhance the efficacy of cisplatin in head and neck cancer}, volume = {64}, year = {2025}, }
• (2025). Escape from flatland: Stereoselective synthesis of hexa-aryl borazines and their sp2-based 3D architectures. ANGEW, 64(29), e202416700. (www)

  @article{ , abstract = {Borazine and its derivatives can be considered critical doping units for engineering hybrid C(sp 2 )-based molecules with tailored optoelectronic properties. Herein, we report the first synthesis of hexa-arylborazines that, bearing ortho -substituted aryl moieties, extend three-dimensionally. Using a one-pot protocol, we first form an electrophilic chloroborazole and then react it with an aryl lithium (ArLi). By selecting the appropriate ortho -substituent, we can guide the ArLi to add to the BN-core in a specific way, ultimately controlling the stereochemical outcome of the three-substitution reaction. Rationalization of the stereochemical model through computational analysis allowed us to show that when aryl lithium nucleophiles bearing rigid long-range ortho -substituents are used, i.e., stiff substituents. The ortho -substituent shields its side of the electrophilic B 3 N 3 core, biasing the incoming ArLi to add anti at each addition step, forming the final tri-aryl borazine exclusively as cc -isomer. Leveraging this stereoselective approach, prototypical multichromophoric borazine derivatives were prepared, and we showcased how the stereochemical arrangement of these chromophores distinctly influences their redox behavior. This methodology paves the way for previously inaccessible borazines to serve as privileged precursors to transcend the conventional bidimensionality associated with graphenoid systems and pioneer the construction of new forms of three-dimensional C(sp 2 )-based architectures.}, archive = {J_ANGEW}, author = {Vivek Chandrakant Wakchaure and María Mercedes Lorenzo-García and Francesco Fasano and Martina Crosta and Nicolas Biot and Nicola Demitri and Pradip Kumar Mondal and Benjamin D. Ward and Davide Bonifazi}, doi = {10.1002/anie.202416700}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {29}, pages = {e202416700}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Escape from flatland: Stereoselective synthesis of hexa-aryl borazines and their sp2-based 3D architectures}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Cost-effective and low-carbon scalable recycling of waste polyethylene terephthalate through bio-based guaiacol-enhanced methanolysis. ANGEW, 64(28), e202582802. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582802}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202582802}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Cost-effective and low-carbon scalable recycling of waste polyethylene terephthalate through bio-based guaiacol-enhanced methanolysis}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Whole-cell lysosome SMLM imaging as indicators for functional diagnostics with a low-phototoxic spontaneously blinking probe. ANGEW, 64(28), e202582801. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582801}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202582801}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Whole-cell lysosome SMLM imaging as indicators for functional diagnostics with a low-phototoxic spontaneously blinking probe}, volume = {64}, year = {2025}, }
• (2025). Front cover: Development of organoautocatalyzed double s-bond c(sp2)-N transamination metathesis reaction (Angew. chem. int. ed. 28/2025). ANGEW, 64(28), e202512751. (www)

  @article{ , archive = {J_ANGEW}, author = {Volker Klein and Florian Schuster and Jonas Amthor and Harald Maid and Prabhakar Bijalwan and Fahmi Himo and Stefano Santoro and Svetlana B. Tsogoeva}, doi = {10.1002/anie.202512751}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202512751}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Front cover: Development of organoautocatalyzed double s-bond c(sp2)-N transamination metathesis reaction (Angew. chem. int. ed. 28/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Carbodicarbene-stibenium ion-mediated functionalization of C(sp3)−H and C(sp)−H bonds”. ANGEW, 64(28), e202512489. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202512489}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202512489}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Carbodicarbene-stibenium ion-mediated functionalization of C(sp3)−H and C(sp)−H bonds”}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Polyphosphorus ligand complexes of coinage metals for multiple capturing of intact p4 tetrahedra (Angew. chem. int. ed. 28/2025). ANGEW, 64(28), e202511458. (www)

  @article{ , archive = {J_ANGEW}, author = {Claudia Göschl and Eugenia Peresypkina and Barbara Hiltl and Alexander V. Virovets and Gabor Balázs and Manfred Scheer}, doi = {10.1002/anie.202511458}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202511458}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Polyphosphorus ligand complexes of coinage metals for multiple capturing of intact p4 tetrahedra (Angew. chem. int. ed. 28/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: A simple quinoid building block for polymer semiconductors with tunable polarity and high n-type thermoelectric performance (Angew. chem. int. ed. 28/2025). ANGEW, 64(28), e202510928. (www)

  @article{ , archive = {J_ANGEW}, author = {Weipeng Sun and Sergio Gámez-Valenzuela and Xiage Zhang and Jin-Woo Lee and Zhicheng Zhong and Peng Wang and Suxiang Ma and Hanqiang Wang and Bumjoon J. Kim and Xugang Guo}, doi = {10.1002/anie.202510928}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202510928}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: A simple quinoid building block for polymer semiconductors with tunable polarity and high n-type thermoelectric performance (Angew. chem. int. ed. 28/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Hierarchically self-assembled anion-coordination-driven gels for guest segregation and electrical sensing (Angew. chem. int. ed. 28/2025). ANGEW, 64(28), e202510921. (www)

  @article{ , archive = {J_ANGEW}, author = {Jie Zhao and Yidan Li and Huidan Zhang and Ruying Lv and Le Yu and Silvia Marchesan and Dong Yang}, doi = {10.1002/anie.202510921}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202510921}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Hierarchically self-assembled anion-coordination-driven gels for guest segregation and electrical sensing (Angew. chem. int. ed. 28/2025)}, volume = {64}, year = {2025}, }
• (2025). Jas s. ward. ANGEW, 64(28), e202509959. (www)

  @article{ , archive = {J_ANGEW}, author = {Jas S. Ward}, doi = {10.1002/anie.202509959}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202509959}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Jas s. ward}, volume = {64}, year = {2025}, }
• (2025). Peter a. korevaar. ANGEW, 64(28), e202509726. (www)

  @article{ , archive = {J_ANGEW}, author = {Peter A. Korevaar}, doi = {10.1002/anie.202509726}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202509726}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Peter a. korevaar}, volume = {64}, year = {2025}, }
• (2025). Red and near-infrared emissive organic crystals: Molecular design and optoelectronic applications. ANGEW, 64(28), e202509140. (www)

  @article{ , abstract = {Red-emissive organic materials play a pivotal role in optoelectronics, including displays, optical communications, organic lasers, and biomedicine, owing to their high penetration and low scattering properties. However, conventional polymer and thin-film emitters often face efficiency losses at long wavelengths and limited operational stability. Organic molecular crystals have emerged as promising alternatives by offering high purity, low defect density, and unique optical anisotropy. Among them, red-emissive organic molecular crystals (ROMCs) remain relatively underdeveloped compared to their blue and green counterparts. Moreover, the inherent brittleness of most crystals poses significant challenges for their integration into flexible and wearable devices. This review highlights recent advances in the design and development of ROMCs, emphasizing molecular and crystal engineering strategies to overcome photophysical limitations and impart mechanical flexibility. Emerging applications in organic lasers, optical waveguides, and bioimaging are discussed, alongside key challenges and future research directions. By bridging fundamental understanding and practical deployment, this perspective offers a comprehensive roadmap for the rational design of flexible, red-light-emitting crystalline materials for next-generation optoelectronic platforms.}, archive = {J_ANGEW}, author = {Linfeng Lan and Hongyu Zhang}, doi = {10.1002/anie.202509140}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202509140}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Red and near-infrared emissive organic crystals: Molecular design and optoelectronic applications}, volume = {64}, year = {2025}, }
• (2025). Supramolecular TADF materials from Calix[3]Acridan and guest-linked polymers for rapid and visual detection of trace benzene. ANGEW, 64(28), e202508987. (www)

  @article{ , abstract = {In this work, a new strategy for rapid and visual detection of trace benzene vapor was reported by utilizing supramolecular thermally activated delayed fluorescence (STADF) polymeric materials via luminescence change mechanism. Consequently, a new type of multi-color STADF polymeric materials GPs@C[3]A were constructed by host–guest complexation between calix[3]acridan (C[3]A) and different guest-linked polymers (GPs). Interestingly, by adjusting the added molar proportion of C[3]A, multi-color TADF property of GPs@C[3]A could also be easily tuned. Notably, when a 20% molar ratio of C[3]A was added, GP1@C[3]A exhibited white luminescence. Especially, by using the high selectivity of C[3]A toward benzene and its differential binding affinities for acceptor guests versus benzene, rapid detection of trace benzene vapor was achieved in few seconds with the naked eyes. The limit of detection concentrations for benzene reached 3.5 mg L −1 , indicating GPs@C[3]A could be used as an excellent sensor for rapid detection of benzene at trace level. Furthermore, GP1@C[3]A could also be fabricated into a visualized and convenient paper-based sensor strip for detecting benzene in cyclohexane. This work offers an innovative idea for the application of STADF materials in detection, and also addresses the key challenge of simultaneously improving sensitivity, selectivity and visualization in benzene detection.}, archive = {J_ANGEW}, author = {Ying Han and Kui-Zhu Song and Yu-Jie Long and Wei-Chen Guo and Ming-Jun Ji and Xiao-Ni Han and Chuan-Feng Chen}, doi = {10.1002/anie.202508987}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202508987}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular TADF materials from Calix[3]Acridan and guest-linked polymers for rapid and visual detection of trace benzene}, volume = {64}, year = {2025}, }
• (2025). Enantioselective divergent cyclization of amide-type 1,6-enynes enabled by H–[Pd]–CN catalysis. ANGEW, 64(28), e202508702. (www)

  @article{ , abstract = {Enantioselective cyclization of 1,6-enynes has been extensively developed as it offers an effective way to obtain chiral cyclic compounds. Herein, we report a divergent palladium-catalyzed enantioselective cyclization of N -allyl-substituted propiolamides, which allows for the efficient synthesis of chiral γ -lactams bearing a quaternary stereogenic center. Three distinctive cyclization strategies, namely, hydrocyanative cyclization, cyclization/Heck reaction, and cyclization/Heck/hydrocyanation, were successfully developed. The product can be selected by using different initial substrates under the same catalytic conditions or by fine-tuning the reaction conditions for the same initial substrate. This catalytic system boasts broad substrate scope and wide functional-group compatibility, where a diverse range of substituents on the aryl group and amide nitrogen atom were tolerated. The combination of experimental studies and theoretical calculations revealed the fundamental role of the ligand in regioselectivity and the role of H 2 O in the sequential cyclization/Heck/hydrocyanation reactions. H 2 O can lower the energy barrier of the reductive elimination step, thus promoting the reaction toward the target product formation.}, archive = {J_ANGEW}, author = {Jinguo Long and Mingdong Jiao and Ting Wang and Xianjie Fang}, doi = {10.1002/anie.202508702}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202508702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective divergent cyclization of amide-type 1,6-enynes enabled by H–[Pd]–CN catalysis}, volume = {64}, year = {2025}, }
• (2025). Equalized dual emissions from copper complexes via multichannel balanced intersystem crossing: Toward 100% quantum efficiencies. ANGEW, 64(28), e202508667. (www)

  @article{ , abstract = {Luminescent materials have important applications in biology, medicine, catalysis, energy, information technology, and so on. However, to suppress quenching and improve efficiencies, how to balance singlet and triplet radiations for efficient dual emission composed of equalized thermally activated delayed fluorescence (TADF) and phosphorescence remains a formidable challenge. Here, we report that based on a rigid skeleton of triphosphine CuI complex, modification with carbazole donors results in high-lying ligand-centered charge transfer states, which provide additional channels for accurately optimizing the singlet-triplet ratios. We achieve equalized dual emissions containing 53% TADF and 47% phosphorescence, ∼100% photo- and electro-luminescence quantum efficiencies and record-high external quantum efficiencies of ∼30% for pure-yellow organic light-emitting diodes. Photophysical and exciton kinetics analyses indicate the incorporation of high-lying ligand-centered triplet states into dual-emissive electroluminescence is based on energy-level matching with the first triplet states of host matrixes.}, archive = {J_ANGEW}, author = {Jixiu Niu and Feifei Gao and Ye Wang and Wu Lu and Jing Zhang and Jiexu He and Xinjin Lou and Yuanxin Ma and Chunbo Duan and Chunmiao Han and Hui Xu}, doi = {10.1002/anie.202508667}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202508667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Equalized dual emissions from copper complexes via multichannel balanced intersystem crossing: Toward 100% quantum efficiencies}, volume = {64}, year = {2025}, }
• (2025). Interfacial water structure modulation on unconventional phase non-precious metal alloy nanostructures for efficient nitrate electroreduction to ammonia in neutral media. ANGEW, 64(28), e202508617. (www)

  @article{ , abstract = {Electrocatalytic nitrate reduction reaction (NO 3 RR) has been recognized as a sustainable route for nitrate removal and value-added ammonia (NH 3 ) synthesis. Regulating the surface active hydrogen (*H) behavior is crucial but remains a formidable challenge, especially in neutral electrolytes, greatly limiting the highly selective NH 3 formation. Herein, we report the controlled synthesis of heterophase hcp/fcc non-precious CuNi alloy nanostructures for efficient NH 3 electrosynthesis in neutral media. Significantly, hcp/fcc Cu 10 Ni 90 exhibits excellent performance with NH 3 Faradaic efficiency and yield rate of 98.1% and 57.4 mg h −1 mg cat −1 , respectively. In situ studies suggest that the high proportion of interfacial K + ion hydrated water (K + –H 2 O) on hcp/fcc Cu 10 Ni 90 creates high *H coverage via boosting interfacial water dissociation, enabling the rapid hydrogenation kinetics for NH 3 synthesis. Theoretical calculations reveal that the superior NO 3 RR performance of hcp/fcc Cu 10 Ni 90 originates from both the existence of hcp phase to improve the electroactivity and the high Ni content to guarantee an efficient active hydrogen supply. The strong interaction between Ni and Cu also optimizes the electronic structures of Cu sites to realize fast intermediate conversions with low energy barriers. This work provides a novel strategy to optimize surface *H behavior via tuning interfacial water structure by crystal phase control.}, archive = {J_ANGEW}, author = {Yunhao Wang and Fengkun Hao and Hongming Xu and Mingzi Sun and Xixi Wang and Yuecheng Xiong and Jingwen Zhou and Fu Liu and Yubing Hu and Yangbo Ma and Xiang Meng and Liang Guo and Chaohui Wang and Mingzheng Shao and Guozhi Wang and Juan Wang and Pengyi Lu and Jinwen Yin and Jie Wang and Wenxin Niu and Chenliang Ye and Qinghua Zhang and Shibo Xi and Bolong Huang and Minhua Shao and Zhanxi Fan}, doi = {10.1002/anie.202508617}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202508617}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial water structure modulation on unconventional phase non-precious metal alloy nanostructures for efficient nitrate electroreduction to ammonia in neutral media}, volume = {64}, year = {2025}, }
• (2025). Chloromethylation modified pyranonitrile-based conjugated microporous polymers for selective one-step two-electron o2 reduction to H2O2. ANGEW, 64(28), e202508436. (www)

  @article{ , abstract = {Hydrogen peroxide (H 2 O 2 ) production utilizing conjugated microporous polymers (CMPs)-based photocatalysts represents a crucial green technology for achieving solar-to-chemical energy conversion. Proper material design is paramount to improve the dispersity and charge transfer of CMPs for enhanced H 2 O 2 production performance. Herein, a post-modification strategy employing chloromethylation reaction was proposed to enhance H 2 O 2 production. The simple one-step chloromethylation reaction simultaneously achieved two objectives: One is enhanced hydrophilicity through the hydrolysis of cyanogen groups in the pyranonitrile unit to carboxyl groups, the other is the improved O 2 adsorption and charge transfer by incorporating chloromethyl groups. The two objectives synergistically enhanced the H 2 O 2 production rate of the chloromethylated CMP named DCM-TPA-Cl, reaching 5.01 mmol g −1 h −1 in air, 6.7-fold of the unmodified photocatalyst. Moreover, the rate achieved at an O 2 atmosphere increased by only 1.8%, highlighting its superior O 2 utilization efficiency in air. An exceptional 38.02 mmol g −1 h −1 rate was further achieved in water/benzyl alcohol mixtures, exceeding most reported polymer photocatalysts. Experimental and theoretical results corroborated the predominant role of the one-step two-electron O 2 reduction pathway in the H 2 O 2 generation. This work demonstrates the potential of a post-modification method to significantly enhance H 2 O 2 production performance directly from water and air.}, archive = {J_ANGEW}, author = {Shiyuan Zhou and Wenwen Chen and Lixuan Kan and Lei Zhu and Wuzi Zhao and Danfeng Wang and Qianfeng Gu and Guangfeng Liu and Qichun Zhang and Peiyang Gu}, doi = {10.1002/anie.202508436}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202508436}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chloromethylation modified pyranonitrile-based conjugated microporous polymers for selective one-step two-electron o2 reduction to H2O2}, volume = {64}, year = {2025}, }
• (2025). Ternary Aldehyde–Copper–Iridium catalysis enables stereodivergent allylation via α-C-H functionalization of primary amines. ANGEW, 64(28), e202508335. (www)

  @article{ , abstract = {α-Chiral primary amines are recognized as one of the most valuable and versatile synthetic intermediates, widely utilized in the construction of diverse amine-containing natural products, pharmaceuticals, and agrochemicals. The direct asymmetric α-C-H functionalization of unprotected primary amines is the most straightforward method for creating these motifs. However, this transformation remains underdeveloped, particularly in stereodivergent synthesis of primary amines with multiple stereocenters. Herein, we report an aldehyde/copper/iridium ternary catalytic system, which was successfully employed for the direct enantio- and diastereodivergent α-allylation of primary α-amino-chromanone without requiring additional protection or activation of the NH 2 group. A wide range of α-tertiary primary amines bearing vicinal stereocenters were prepared in high yields with excellent enantio- and diastereoselectivities (generally >20:1 dr and >99% ee). Notably, all four stereoisomers of the α-tertiary amines can be readily prepared by simply switching the configuration combinations of the two chiral metal catalysts. Furthermore, the asymmetric induction model for the α-C-H functionalization of primary amines was meticulously elucidated through comprehensive density functional theory (DFT) calculations.}, archive = {J_ANGEW}, author = {Zijiao Liu and Panpan Li and Haoyang Wang and Jiacheng Zhang and Xiaohong Huo and Zhen-Liang Sun and Wanbin Zhang}, doi = {10.1002/anie.202508335}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202508335}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ternary Aldehyde–Copper–Iridium catalysis enables stereodivergent allylation via α-C-H functionalization of primary amines}, volume = {64}, year = {2025}, }
• (2025). Intrinsically luminescent nematic liquid crystals enabling high-brightness full-color and white circularly polarized luminescence via chiral coassembly. ANGEW, 64(28), e202507802. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) materials with simultaneous high dissymmetry factor ( g lum ) and brightness are pivotal for advanced photonic applications but remain challenging due to inherent trade-offs betwwen g lum value and photoluminescenc quantum yield (PLQY). Here, we report a supramolecular engineering strategy to construct intrinsically luminescent chiral nematic liquid crystal (N*-LC) films via coassembly of luminescent liquid crystals (LLCs) and chiral dopant. First, five intrinsic LLCs molecules ( 2PFQ , 2PFBQ , 2PFB , 2PFSe , and 2PFS ) were synthesized by combining the biphenyl framework with dioctyl-functionalized fluorene, achieving exceptional nematic phases and high brightness with PLQY up to 99%. Then, chiral coassembly of the obtained LLCs with chiral dopants ( P / M- THH ) followed by rapid thermal quenching yielded Bragg reflection-free N*-LC films exhibiting high-brightness CPL with recorded g lum values (up to 0.75) and PLQY (up to 71%). Full-color tunability and white CPL (CIE: 0.33, 0.33) were realized through precise compositional control. The simultaneous optimization of g lum and PLQY enables high-brightness CPL with advanced anticounterfeiting capabilities, opening new avenues for developing high-brighness CPL materials for polarized photonic and optoelectronic applications.}, archive = {J_ANGEW}, author = {Zhen-Xing Yu and Xu-Wei Chen and Chuan-Feng Chen and Meng Li}, doi = {10.1002/anie.202507802}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507802}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intrinsically luminescent nematic liquid crystals enabling high-brightness full-color and white circularly polarized luminescence via chiral coassembly}, volume = {64}, year = {2025}, }
• (2025). Construction of shamrock-shaped giant molecule acceptors for efficient organic solar cells. ANGEW, 64(28), e202507616. (www)

  @article{ , abstract = {The discovery of non-fullerene small molecule acceptor materials has breathed new development into organic solar cells (OSCs). However, it has also introduced the issue of insufficient device stability. Enhancing the glass transition temperature ( T g ) of materials by connecting small molecules into giant molecules, thereby improving morphological stability, represents an effective material design strategy to address this issue. In this work, we have synthesized the shamrock-shaped giant molecule materials T-Qx based on high efficiency Qx-series small molecule materials. Through systematically modulating the terminal and the central halogen atoms, precise control of the molecular conformation can be achieved. Notably, the fully chlorine-substituted giant molecule T-Qx-15Cl exhibits the largest torsion angle of approximately 40° and achieves the highest T g (up to 188 °C) among these new materials. Photovoltaic devices based on these giant molecules demonstrate a low non-radiative energy loss of approximately 0.21 eV, which results in a high open-circuit voltage ( V oc ) above 0.93 V. T-Qx-15Cl presents the strongest interaction with the polymer donor PM6, achieving a power conversion efficiency (PCE) of more than 20%. This remarkable performance is attributed to the large twisting angle that effectively prevents the excessive aggregation of large π-conjugated planar molecules.}, archive = {J_ANGEW}, author = {Shengjie Xu and Qixin He and Xiaonan Xue and Jiawei Deng and Fei Han and Fei Xie and Xuechen Jiao and Libo Zhou and Rui Zeng and Zaiyu Wang and Ming Zhang and Lei Zhu and Hao Jing and Yongming Zhang and Feng Liu}, doi = {10.1002/anie.202507616}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of shamrock-shaped giant molecule acceptors for efficient organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Constructing ionic transport network via supramolecular composite binder in cathode for all-solid-state lithium batteries. ANGEW, 64(28), e202507579. (www)

  @article{ , abstract = {Binders play a pivotal role in maintaining the structural integrity and stability of electrodes. However, conventional polyvinylidene fluoride binder with low ionic conductivity could not meet the ionic transport requirements of the cathode in all-solid-state lithium batteries (ASSLBs). Herein, a composite binder (PPCL) derived from the cross-linking of linear molecules and mechanically interlocked molecules with typical supramolecular channel structure is designed. The supramolecular channel structure is afforded through β−cyclodextrin rings crosslinked polyethylene oxide chains by hydrogen bond interaction. Through the coordination of supramolecular with linear polymer, the PPCL binder provides multiple and synergistic Li + transport channels to achieve stable Li + transport inside the cathode. As a result, the obtained PPCL binder not only maintains exceptional adhesive strength which could achieve robust electrode structural stability but also helps to construct multiple and highly efficient Li + transport channels. Therefore, with PPCL binder, the LiFePO 4 -based ASSLBs show an excellent rate capability and long cyclic stability over 1000 cycles at 1 C. Notably, a pouch ASSLB shows excellent cycling stability over 250 cycles at 0.2 C. This work provides guidance on designing high-loading cathodes for advanced ASSLBs.}, archive = {J_ANGEW}, author = {Haixing Liu and Suqing Wang and Wenhan Kong and Yangxi Liu and Haihui Wang}, doi = {10.1002/anie.202507579}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing ionic transport network via supramolecular composite binder in cathode for all-solid-state lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Xanthopinacol boronate: A robust, photochemically assembled and cleavable boronic ester for orthogonal chemistry. ANGEW, 64(28), e202507571. (www)

  @article{ , abstract = {Organoboronic acids impact numerous fields of application from organic synthesis to drug discovery and materials science. However, their highly polar nature makes them challenging to handle, purify, and characterize. Boronic esters help overcome these issues, and pinacol esters (Bpin) have become the dominant boronic acid surrogate in organic synthesis. Despite its popularity, Bpin is not without drawbacks. Its formation from pinacol is intrinsically reversible in the presence of water or alcohols, which may cause premature release leading to losses during reactions and purification. This reversibility complicates the hydrolytic regeneration of free boronic acids, which often requires additional steps to destroy the pinacol by-product. Although other boronyl protecting groups exist, their removal requires harsh pH conditions. To address these issues, we developed xanthopinacol boronates (Bxpin), a robust protecting group for boronic acids with excellent orthogonality in various chemical reactions and mild irreversible removal under catalyzed photoredox conditions. Xpin boronates can be obtained directly by irradiation of a mixture of free boronic acid and xanthone with UV light, causing an in situ dimerization of xanthone to the required xanthopinacol. The unique attributes of xpin boronates were further studied by UV–vis spectrophotometry, X-ray crystallography, cyclic voltammetry, and various stability tests.}, archive = {J_ANGEW}, author = {David M. Heard and Martin C. Lessard and Dennis G. Hall}, doi = {10.1002/anie.202507571}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Xanthopinacol boronate: A robust, photochemically assembled and cleavable boronic ester for orthogonal chemistry}, volume = {64}, year = {2025}, }
• (2025). Preparation of cyclic olefin polymers via group transfer radical cyclopolymerization for high performance in anode-free batteries. ANGEW, 64(28), e202507557. (www)

  @article{ , abstract = {Cyclic olefin polymers (COPs) are of high importance in optical and medical materials. These materials are typically synthesized via ring-opening metathesis polymerization of norbornene derivatives, using metallocene catalysts, followed by high-pressure hydrogenation catalyzed by noble metals. However, the complex synthetic processes, the continuous use of expensive catalysts, and the need to remove metal residues remain substantial barriers in COP production. In contrast, radical cyclopolymerization of dienes, which eliminates the need for metal catalysis and hydrogenation, offers a promising alternative for COP synthesis. Nevertheless, chain transfer reactions hinder the radical polymerization of non-conjugated dienes. To address these challenges, we present a novel strategy, group transfer radical cyclopolymerization (GTRCP), which effectively suppresses chain transfer and enables radical polymerization of dienes to yield COPs. This approach allows for the production of a broad range of sequence-regulated COPs with high molecular weights and low dispersity. Density functional theory calculations support the proposed GTRCP mechanism, highlighting its efficiency and selectivity, driven by substantial thermodynamic forces. The resulting COPs demonstrate great potential as the interphase layer materials in anode-free lithium metal batteries, significantly enhancing the cycling performance towards practical energy storage applications.}, archive = {J_ANGEW}, author = {Yasu Chen and Shuo Wang and Tongkun Wang and Xianjin Wang and Hao Sun and Chen Zhu}, doi = {10.1002/anie.202507557}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507557}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Preparation of cyclic olefin polymers via group transfer radical cyclopolymerization for high performance in anode-free batteries}, volume = {64}, year = {2025}, }
• (2025). Tri-coordinated boron species in confined boron oxide catalysts for enhanced low-temperature oxidative dehydrogenation of propane. ANGEW, 64(28), e202507525. (www)

  @article{ , abstract = {Boron-based catalysts exhibit great potential for oxidative dehydrogenation of propane (ODHP) to produce olefins. The straightforward synthesis of confined boron-based catalysts commonly using H 3 BO 3 is intractable because of its abundant hydroxyl groups easily interacting with the supports in a spatially nonselective manner. Herein, we managed to construct a confined BO x @SiO 2 catalyst showing an impressive low-temperature (400 °C) activity. This catalyst was prepared via the encapsulation of BN nanosheets by SiO 2 shell and subsequent oxidization steps. The in situ generated boron–oxygen species were anchored to silica shells via B─O─Si and hydrogen bonds. BO x @SiO 2 exhibited a unique catalytic behavior of propane conversion uprush, increasing from 5.3% at 410 °C to 28.4% at 424.6 °C for ODHP reaction. That was attributed to the efficient activation of propane triggered by the newly formed tri-coordinated B─OH (B[3] a and B[3] b ) active sites from the dispersion of molten BO x species in confined SiO 2 . Ab initio molecular dynamics (AIMD) simulations revealed that in the confined structure, the bond angles of O─B─O and B─O─B and system disorder of BO x species increased significantly in molten state, favoring the dispersion of BO x species and formation of B─OH groups, which drove the uprush of propane conversion.}, archive = {J_ANGEW}, author = {Yuenan Zheng and Weixi Chen and Zhankai Liu and Wen-Duo Lu and Wen-Cui Li and Dongqi Wang and An-Hui Lu}, doi = {10.1002/anie.202507525}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507525}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tri-coordinated boron species in confined boron oxide catalysts for enhanced low-temperature oxidative dehydrogenation of propane}, volume = {64}, year = {2025}, }
• (2025). Strain energy induced rotary speed acceleration in a light-driven molecular motor. ANGEW, 64(28), e202507487. (www)

  @article{ , abstract = {Light-driven molecular motors based on overcrowded alkenes represent a major type of molecular machines that are able to rotate unidirectionally. The regulation of the rotary speed without altering the core structure of a motor is crucial and remains a major challenge. In the present study, we reported that the rotary speed of molecular motors can be significantly enhanced by harnessing the strain energy of cycloparaphenylene (CPP). A series of molecular motors incorporated in CPP with varying sizes were synthesized, and their photochemical and thermal isomerization behaviors were meticulously examined using UV–vis and 1 H NMR spectroscopy. The remarkable increase of the acceleration effect of the rotary speed with decreasing macrocycle sizes, up to 389-fold, can be attributed to the strain energy induced bending in the stator part, which reduces steric hindrance in the “ fjord region ” of the molecule, supported by a detailed computational study employing density functional theory. This work provides systematic insight into the behavior of molecular motors under strain energy, thereby paving the way for the application of motor-incorporating CPPs as a general strategy to accelerate the rotary speed of molecular motors.}, archive = {J_ANGEW}, author = {Kai Lan and Shilong Zhang and Yi Lu and Peiyuan Yu and Jiawen Chen and Chuyang Cheng}, doi = {10.1002/anie.202507487}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507487}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strain energy induced rotary speed acceleration in a light-driven molecular motor}, volume = {64}, year = {2025}, }
• (2025). Effective hole utilization for atomically dispersed low-coordination molybdenum accelerating photocatalytic C─H activation. ANGEW, 64(28), e202507312. (www)

  @article{ , abstract = {Photocatalytic acceptorless dehydrogenation of alcohols offers a promising strategy to produce the corresponding carbonyl compounds and clean fuel H 2 . However, the sluggish kinetics of the alkoxy C─H bond cleavage attributes to the inefficient utilization of photogenerated holes greatly restricts the photocatalytic activity. Here we develmically dispersed low-coordination Mo on ultrathin ZnIn 2 S 4 nanosheets that can greatly accelerate photocatalytic C─H activation. An internal quantum efficiency of 45.2% at 400 nm together with 99% benzaldehyde (BAD) selectivity is achieved using benzyl alcohol (BA) as a model substrate. Extensive experimental characterizations and theoretical calculations reveal that the low-coordination Mo tunes the local atomic configuration of highest occupied molecular orbital to trap holes produced under photoexcitation within picoseconds. Moreover, the incorporated site-specific Mo greatly improves the lifetime and diffusion length of photogenerated holes and optimizes the driving force of alkoxy C─H activation, which are responsible for the excellent performance. This work marks a significant stride to enhance the utilization efficiency of holes for promoting photocatalytic C─H activation.}, archive = {J_ANGEW}, author = {Wangxi Liu and Jingwen Jiang and Zhonghua Li and Bin Gao and Changhao Liu and Chen Liu and Weichang Hao and Rongli Fan and Jianming Liu and Tao Yu and Zhigang Zou and Zhaosheng Li}, doi = {10.1002/anie.202507312}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Effective hole utilization for atomically dispersed low-coordination molybdenum accelerating photocatalytic C─H activation}, volume = {64}, year = {2025}, }
• (2025). Design of intrinsically stable hole-selective self-assembled monolayers by introducing fused-ring intramolecular Donor–Acceptor interactions. ANGEW, 64(28), e202507273. (www)

  @article{ , abstract = {Hole-selective self-assembled monolayers (SAMs) incorporating electron-donating conjugated units as head groups have witnessed remarkable success in helping achieve high-performance organic solar cells (OSCs). However, these molecules frequently exhibit a shallow lowest unoccupied molecular orbital (LUMO) level, rendering them prone to photodegradation. To tackle this problem, we introduce fused-ring intramolecular donor–acceptor (D–A) interactions into the design of SAM molecules to downshift the LUMO level. The resultant molecule, JJ32, shows both enhanced photostability and intermolecular interactions. Furthermore, the fused-ring intramolecular D–A interactions also help stabilize the radical cation state of JJ32 to result in significantly improved redox stability. This enables them to be included in polyoxometalate (POM)-based composite hole-selective layers (HSLs), resulting in an impressive efficiency of 19.85% alongside significantly enhanced stability in corresponding OSCs. This study not only validates the concept of using fused-ring D–A-structure SAMs to improve the efficiency and stability of OSCs but also elucidates the relationship between SAM structures and POM doping behaviors to provide an effective strategy in designing intrinsically stable SAM molecules for high-performance OSCs.}, archive = {J_ANGEW}, author = {Wenlin Jiang and Baobing Fan and Lingchen Kong and Ze-Fan Yao and Wansong Shang and Chun-To Wong and Francis R. Lin and Alex K.-Y. Jen}, doi = {10.1002/anie.202507273}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507273}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of intrinsically stable hole-selective self-assembled monolayers by introducing fused-ring intramolecular Donor–Acceptor interactions}, volume = {64}, year = {2025}, }
• (2025). Iridium-catalyzed asymmetric β-selective hydroamination of enamides for the synthesis of 1,2-diamines. ANGEW, 64(28), e202507200. (www)

  @article{ , abstract = {An iridium-catalyzed highly enantioselective hydroamination of electron-rich alkenes has been developed. The coordination assistance of the amide group to the metal center effectively overrides the inherent electronic preference of N─H addition to an enamide, delivering unconventional β-selectivity. Phthalimide is utilized as a readily removable amination agent. This methodology enables direct access to enantio-enriched 1,2-diamines from readily available materials with 100% atom economy, exclusive regioselectivity, and excellent enantioselectivity (up to 99% ee).}, archive = {J_ANGEW}, author = {Yu-Wen Sun and Hao-Tian Tan and Sheng-Nan Sun and Bi-Jie Li}, doi = {10.1002/anie.202507200}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507200}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iridium-catalyzed asymmetric β-selective hydroamination of enamides for the synthesis of 1,2-diamines}, volume = {64}, year = {2025}, }
• (2025). Valence tautomerism and alkaline properties of global aromatic imine- and methine-bridged all-benzenoid macrocyclic superpyrazine and supertriazine. ANGEW, 64(28), e202507187. (www)

  @article{ , abstract = {The comprehensive understanding of the ground-state electronic structures of all-benzenoid macrocycles and their charged species, particularly those exhibiting global (anti)aromaticity, remains poorly resolved. Here, we present two imine- and methine-bridged all-benzenoid [6]cyclo- para -phenylenes SPAZ (superpyrazine) and STAZ (supertriazine)-designed as π-extended analogues of 1,4-pyrazine and 1,3,5-triazine, respectively. For the first time, we elucidate their unprecedented valence tautomerism between “super-Kekulé” alternating benzenoid/quinoidal structures and a “super-sextet” transient structure, mediated by a 30π azaannulene conjugated pathway. The aromatic stabilization energy of global aromatic delocalization would partially counterbalance the energy penalty for disrupting three benzenoid sextets. Further protonation studies demonstrate their alkaline characteristics (p K a = 0.97 for SPAZ ; 3.27 for STAZ ), with diprotonated SPAZ-DH and monoprotonated STAZ-MH adopting planarized geometries that amplify global aromaticity through charge-induced structural constraints and enhanced π-electron delocalization. Notably, two-electron reduction generates a dianion SPAZ-DA exhibiting 32π electron global antiaromaticity with amine N atom embedded aza[30]annulene pathway. These findings establish a framework for decoding electronic structure property relationships in all-benzenoid macrocycles, offering insights into aromaticity modulated regulations through tautomerism, protonation, and redox switching.}, archive = {J_ANGEW}, author = {Xinyue Tian and Zekun Tong and Yi Han and Tingxi Yu and Johnathan Joo Cheng Lee and Chunyan Chi and Shaoqiang Dong}, doi = {10.1002/anie.202507187}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507187}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Valence tautomerism and alkaline properties of global aromatic imine- and methine-bridged all-benzenoid macrocyclic superpyrazine and supertriazine}, volume = {64}, year = {2025}, }
• (2025). From binary to higher-order organic cocrystals: Design principles and performance optimization. ANGEW, 64(28), e202507102. (www)

  @article{ , abstract = {Organic cocrystals, particularly the evolution from binary to higher-order structures, have garnered considerable attention due to their tunable intermolecular interactions and unique material properties. Binary cocrystals, formed through π-π stacking, charge transfer, and hydrogen/halogen bonding, allow for precise control over molecular packing and enhanced optoelectronic properties. In contrast, higher-order cocrystals, incorporating three or more components, enable greater complexity and functional diversity. Strategies such as homologation via isostructural substitution, hierarchical intermolecular interactions, and long-range Synthon Aufbau Modules facilitate the synthesis of these advanced materials. The shift toward higher-order cocrystals paves the way for novel applications in fields such as deep learning for cocrystal prediction, drug design, organic solar cells, and NIR-II photothermal conversion. However, challenges related to molecular screening, ratio optimization, scalable synthesis, and long-term stability remain critical hurdles for the broader implementation of these materials in practical applications.}, archive = {J_ANGEW}, author = {Jia-Hao Jiang and Shuai Zhao and Yanqiu Sun and Xue-Dong Wang}, doi = {10.1002/anie.202507102}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507102}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From binary to higher-order organic cocrystals: Design principles and performance optimization}, volume = {64}, year = {2025}, }
• (2025). Selective CO electroreduction to multicarbon oxygenates over atomically dispersed Cu–Ag sites in alkaline membrane electrode assembly electrolyzer. ANGEW, 64(28), e202507062. (www)

  @article{ , abstract = {Electrochemical carbon monoxide reduction reaction (CORR) to produce multicarbon (C 2+ ) oxygenates using renewable electricity is a promising carbon utilization pathway. However, the performance of this process suffers from low C 2+ oxygenates selectivity and insufficient current density. Here, we employed a Cu–Ag bimetallic strategy to enhance the selectivity of C 2+ oxygenates from CORR in alkaline membrane electrode assembly electrolyzer at ampere-level current densities. The Cu–Ag catalysts prepared by magnetron sputtering feature atomically dispersed Cu–Ag sites on the catalyst surface, which are key to promoting the formation of C 2+ oxygenates. Increasing Ag content favors C 2+ oxygenates formation while inhibiting ethylene production. The optimized Cu 2 Ag catalyst achieved Faradaic efficiency of 71.4% for C 2+ oxygenates at 2.5 A cm −2 . In situ spectroscopy and density functional theory calculations revealed that atomically dispersed Cu–Ag sites on the catalyst surface promote the dissociation of *COCOH to *CCO, thus favoring C 2+ oxygenates formation.}, archive = {J_ANGEW}, author = {Xinhui Guo and Tianfu Liu and Yanpeng Song and Rongtan Li and Pengfei Wei and Ziqi Liao and Zichao Wu and Dunfeng Gao and Qiang Fu and Guoxiong Wang and Xinhe Bao}, doi = {10.1002/anie.202507062}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective CO electroreduction to multicarbon oxygenates over atomically dispersed Cu–Ag sites in alkaline membrane electrode assembly electrolyzer}, volume = {64}, year = {2025}, }
• (2025). Asymmetric coordination in cobalt single-atom catalysts enables fast charge dynamics and hierarchical active sites for two-stage kinetics in photodegradation of organic pollutants. ANGEW, 64(28), e202507028. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) have attracted growing interest in solar-driven catalysis, though challenges persist due to symmetrical metal coordination, which results in limited driving force and sluggish charge dynamics. Additionally, uneven energy and mass distribution complicate reaction pathways, ultimately restricting solar energy utilization and catalytic efficiency. Herein, we synthesized cobalt single atoms decorated carbon nitride catalysts featuring a highly asymmetric Co─C 2 N 3 coordination, tailored for photocatalytic organic pollutants removal. Advanced experimental studies and simulation results collectively revealed that the unique microenvironment surrounding Co single atoms improved charge dynamics and created reactive hot spots, facilitating the generation of reactive oxygen species during the photocatalytic degradation of organic pollutants. These enhanced charge dynamics, combined with hierarchical active sites, resulted in two-stage reaction kinetics and excellent stability for the degradation of bisphenol A in wastewater, distinctly outperforming the first-stage kinetics observed for polymeric carbon nitride. This work advances the understanding of structure-performance relationships in SAC-based photocatalytic degradation and offers valuable insights for the design of next-generation SACs in environmental catalysis.}, archive = {J_ANGEW}, author = {Xiaoming Liu and Yang Zhang and Puhua Sun and Fengting He and Yuzhao Wu and Shuaijun Wang and Shaobin Wang and Jinqiang Zhang}, doi = {10.1002/anie.202507028}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202507028}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric coordination in cobalt single-atom catalysts enables fast charge dynamics and hierarchical active sites for two-stage kinetics in photodegradation of organic pollutants}, volume = {64}, year = {2025}, }
• (2025). Dinitrogen activation with low-valent strontium. ANGEW, 64(28), e202506989. (www)

  @article{ , abstract = {DFT calculations on β-diketiminate (BDI) complexes with the full series of alkaline-earth (Ae) metals show that (BDI)AeAe(BDI) complexes of the heavier Ae metals (Ca, Sr, Ba) have long weak Ae─Ae bonds that are prone to homolytic bond cleavage. However, isolation of (BDI)Sr(μ-N 2 )Sr(BDI) with a side-on bridging N 2 2− dianion should thermodynamically be feasible. Attempts to stabilize such a complex with the super bulky BDI* ligand failed (BDI* = HC[(Me)C = N-DIPeP] 2 , DIPeP = 2,6-Et 2 CH-phenyl). First, N 2 fixation with a Sr complex was enabled by a heterobimetallic approach. Reduction of ( DIPeP NN)Sr with potassium gave ( DIPeP NN) 2 Sr 2 K 2 (N 2 ) ( 6 -Sr); DIPeP NN = DIPeP N-Si(Me) 2 CH 2 CH 2 Si(Me) 2 -N DIPeP . A similar Ca product was also isolated ( 6 -Ca). Crystal structures reveal a N 2 2− anion with side-on bonding to Ae 2+ and end-on coordination to K + . DFT calculations and Atoms-In-Molecules analyses show mainly ionic bonding. Both 6 -Ae complexes are synthons for hitherto unknown (BDI*)AeAe(BDI*) (Ae = Ca, Sr) and react by releasing N 2 and two electrons. Although surprisingly stable in benzene, the reduction of I 2 and H 2 is facile. Fast reaction with Teflon led to formation of crystalline [( DIPeP NN)SrKF] 2 ( 7 ), which is labile and decomposed to KF and ( DIPeP NN)Sr. Latter reactivity underscores potential use of 6 -Ae complexes as very strong, hydrocarbon-soluble reducing agents.}, archive = {J_ANGEW}, author = {Michael Morasch and Timothy Vilpas and Neha Patel and Johannes Maurer and Stefan Thum and Marcel A. Schmidt and Jens Langer and Sjoerd Harder}, doi = {10.1002/anie.202506989}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506989}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dinitrogen activation with low-valent strontium}, volume = {64}, year = {2025}, }
• (2025). Metal-free divergent Hydroboration/Multiboration of terminal alkynes via markovnikov pathway. ANGEW, 64(28), e202506968. (www)

  @article{ , abstract = {Hydroboration/multiboration of alkynes has been considered a straightforward route for the construction of high-value alkenylboronates and multiborylalkanes, especially reflected by the productions of β -alkenylboronates and related multiborylalkanes based on the anti -Markovnikov-type transformations of terminal alkyne. However, the syntheses of branched α -alkenylboronates and related multiborylalkanes remain elusive due to the thermodynamically and kinetically unfavorable Markovnikov hydroboration process. Herein, we present a conceptually novel metal-free approach for Markovnikov hydroboration of terminal alkynes to achieve the α -alkenylboronates. Derived from it, we have successfully realized unprecedented tailor-made multiborations (2,2-dihydroboration, 1,2,2-triboration, and 1,2-dihydroboration) of alkynes by simply changing the proton sources and solvents. The broad substrate scope and outstanding chemo- and regioselectivities of the developed approaches unlock opportunities to exploit these formerly unattainable organoboronates, thereby expanding uncharted chemical space. The preliminary mechanistic studies highlight the synergistic roles of amide solvents, suitable proton sources, and B 2 cat 2 in facilitating these tunable transformations.}, archive = {J_ANGEW}, author = {Min-Jie Zhou and Ke Xu and Yanwei Gu and Yinjun Xie}, doi = {10.1002/anie.202506968}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506968}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-free divergent Hydroboration/Multiboration of terminal alkynes via markovnikov pathway}, volume = {64}, year = {2025}, }
• (2025). Unlocking one-step two-electron oxygen reduction via metalloid boron-modified Zn3In2S6 for efficient H2O2 photosynthesis. ANGEW, 64(28), e202506963. (www)

  @article{ , abstract = {The indirect two-step two-electron oxygen reduction reaction (2e − ORR) dominates photocatalytic H 2 O 2 synthesis but suffers from sluggish kinetics, •O 2 − -induced catalyst degradation, and spatiotemporal carrier-intermediate mismatch. Herein, we pioneer a metal-metalloid dual-site strategy to unlock the direct one-step 2e − ORR pathway, demonstrated through boron-engineered Zn 3 In 2 S 6 ( B-ZnInS ) photocatalyst with In-B dual-active sites. The In-B dual-site configuration creates a charge-balanced electron reservoir by charge complementation, which achieves moderate O 2 adsorption via bidentate coordination and dual-channel electron transfer, preventing excessive O─O bond activation. Simultaneously, boron doping induces lattice polarization to establish a built-in electric field, quintupling photogenerated carrier lifetimes versus pristine ZnInS . These synergies redirect the O 2 activation pathway from indirect to direct 2e − ORR process, delivering an exceptional H 2 O 2 production rate of 3121 µmol g −1 h −1 in pure water under simulated AM 1.5G illumination (100 mW cm −2 )—an 11-fold enhancement over ZnInS . The system achieves an unprecedented apparent quantum yield of 49.8% at 365 nm for H 2 O 2 photosynthesis among inorganic semiconducting photocatalysts, and can continuously produce medical-grade H 2 O 2 (3 wt%). This work provides insights for designing efficient H 2 O 2 photocatalysts and beyond.}, archive = {J_ANGEW}, author = {Ji-Li Zhou and Yan-Fei Mu and Meng Qiao and Meng-Ran Zhang and Su-Xian Yuan and Min Zhang and Tong-Bu Lu}, doi = {10.1002/anie.202506963}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506963}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking one-step two-electron oxygen reduction via metalloid boron-modified Zn3In2S6 for efficient H2O2 photosynthesis}, volume = {64}, year = {2025}, }
• (2025). Regulated second-sphere coordination in amorphous metal-organic framework for efficient CO2 fixation. ANGEW, 64(28), e202506960. (www)

  @article{ , abstract = {The endeavor toward photocatalytic CO 2 fixation is largely hampered by the rigid spatial configurations and inadequate orbital overlap between the catalytic site and CO 2 . Herein, we propose a second-sphere coordination regulation strategy by atomically tailoring the metal–metal coordination of the secondary building unit (SBU). Amorphous metal-organic framework (a-MOF) is constructed as proof-of-concept to achieve creative control over the second coordination sphere. Such architecture transforms rigid trinuclear nodes into flexible dinuclear motifs. This shift can open spatial proximity to access the guest molecules and optimize s–π* overlap by enabling orbital reorientation. Both in situ experiments and theoretical calculations verify second-sphere engineering endows the Lewis base sites with high electron donating capacity and promotes the electron injection into the π * anti-bonding orbitals of the CO 2 molecule effectively. Hence, the a-MOF displays approximately double the yield in various photocatalytic CO 2 reactions compared with its crystalline counterpart. Moreover, its photo-assisted Li-CO 2 battery delivers higher discharging voltage and a fourfold increment of discharge capacity at 200 µA cm −2 . The unique ability to tailor the secondary coordination sphere performs attractive merits governing the small molecule binding affinity, aiming to manipulate the local microenvironment of open metal sites for efficient CO 2 fixation.}, archive = {J_ANGEW}, author = {Hang Wang and Yi Liu and Lei Li and Jing Zhang and Mi Luo and Zhixin Sun and Yuxin Xiao and Xingwu Zhai and Liang Wu and Hongjun Zhang and Bangjiao Ye and Cheng Yang and Xiaodong Zhang and Min Zhou}, doi = {10.1002/anie.202506960}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506960}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulated second-sphere coordination in amorphous metal-organic framework for efficient CO2 fixation}, volume = {64}, year = {2025}, }
• (2025). Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo. ANGEW, 64(28), e202506954. (www)

  @article{ , abstract = {Lipid nanoparticles (LNPs) are currently the most clinically advanced mRNA delivery vectors. However, optimizing LNPs for in vivo applications remains largely empirical. The apparent p K a of LNPs is a predictive factor for in vivo performance, with p K a values between 6 and 7 showing the highest efficacy. Despite this critical role of ionizable lipids in LNPs, the relationship between lipid structure and its influence on LNP p K a remains poorly studied. In this study, we report the design and the synthesis of a novel class of ionizable lipids featuring a thioamide moiety, enabling direct comparison between thioamide-containing (SAM) LNPs and amide-containing (OAM) LNPs. We find that substituting oxygen with sulfur in the amide group significantly decreases the apparent p K a of LNPs, increasing the likelihood of identifying lipids in combinatorial libraries that yield LNPs with a p K a in the desired 6–7 range. The reduction in p K a in LNPs containing SAM lipids, compared with OAM lipids, is attributed to the increased hydrophobicity of the thioamide group. Furthermore, by synthesizing multiple libraries of SAM lipids and varying the ionizable head group, alkyl chains, and linker length, we discovered thioamide lipids with distinct tissue tropism, including lipids that mediate splenic targeting by LNPs.}, archive = {J_ANGEW}, author = {Yong Chen and Emily De Lombaerde and Aimée Bugler-Lamb and Zifu Zhong and Martijn J. Schuijs and Claudia M. Brenis Gomez and Jamie De Baere and Mark Gontsarik and Heleen Lauwers and Kim Deswarte and Niek N. Sanders and Bart N. Lambrecht and Martin Guilliams and Bruno G. De Geest}, doi = {10.1002/anie.202506954}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506954}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bonded organic framework with desolventization and lithium-rich sites for high-performance lithium metal anodes. ANGEW, 64(28), e202506892. (www)

  @article{ , abstract = {Effectively managing Li + migration behaviors and addressing the issues of side reactions at the electrolyte–electrode interface is crucial for advancing high-performance lithium metal batteries (LMBs). Herein, this work introduces a two-dimensional hydrogen-bonded organic framework (HOF) enriched with multi-site H-bonding and lithiophilic sites for the first time to tailor the electronic structure and solvation chemistry in lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) based electrolyte and stabilize the lithium metal anodes (LMAs) interface. Initially, the abundant lithiophilic sites (C═O, C═N) in the HOF coordinate with Li + , acting as key electron donors to optimize the electronic structure while also reducing the desolvation energy barrier when Li + dissociates from the solvent sheath. Moreover, the multifunctional hydrogen bonding not only acts as the “appended manipulator” to anchor -NH 2 to LiTFSI and reduces the adverse reactions at the LMAs interface but also mitigates the mechanical stress during lithium deposition. As evidenced by various in / ex situ characterizations, the HOF-modified lithium-metal symmetric batteries exhibit ultra-long cycling performance (11 000 h) and low voltage fluctuations at 3 mA cm −2 . This unique strategy of hydrogen-bonded synergistic lithiophilic sites provides a new perspective on the design of artificial interfacial layers for stabilizing lithium metal batteries.}, archive = {J_ANGEW}, author = {Songling Wu and Xiaomeng Lu and Yiwen Sun and Haichao Wang and Muhammad Ahsan Waseem and Junaid Aslam and Yi Xu and Li-Ping Lv and Yong Wang}, doi = {10.1002/anie.202506892}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506892}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bonded organic framework with desolventization and lithium-rich sites for high-performance lithium metal anodes}, volume = {64}, year = {2025}, }
• (2025). Stereocontrol in conformationally stable C(sp2)─C(sp3) atropisomers. ANGEW, 64(28), e202506810. (www)

  @article{ , abstract = {We report a two-step sequence for the enantioselective construction of a rare family of stable C(sp 2 )─C(sp 3 ) atropisomers featuring two additional stereogenic centers. The process begins with an organocatalyzed dihydrobenzofurannulation that establishes and controls the stereochemistry of two carbon centers, followed by a highly diastereoselective functionalization that significantly enhances the barrier to diastereomerization of the C(sp 2 )─C(sp 3 ) bond, effectively locking and stabilizing its configuration.}, archive = {J_ANGEW}, author = {Antoine Domain and Guishun Bai and Juan-Carlos Castillo and Hassane Moussa Abdraman and Stéphane Humbel and Michel Giorgi and Jean-Valère Naubron and Sara Chentouf and Jean Rodriguez and Xiaoze Bao and Damien Bonne}, doi = {10.1002/anie.202506810}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506810}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereocontrol in conformationally stable C(sp2)─C(sp3) atropisomers}, volume = {64}, year = {2025}, }
• (2025). Multiple-asymmetric molecular engineering enables regioregular selenium-substituted acceptor with high efficiency and ultra-low energy loss in binary organic solar cells. ANGEW, 64(28), e202506795. (www)

  @article{ , abstract = {Asymmetric molecular engineering is utilized for developing efficient small molecular acceptors (SMAs), whereas adopting multiple asymmetric strategies at the terminals, side chains, and cores of efficient SMAs remains a challenge, and effects on reducing energy loss ( E loss ) have been rarely investigation. Herein, four regioregular multiple-asymmetric SMAs ( DASe-4F , DASe-4Cl , TASe-2Cl2F , and TASe-2F2Cl ) are constructed by delicately manipulating the number and position of F and Cl on end groups. Triple-asymmetric TASe-2F2Cl not only exhibits a unique and most compact 3D network crystal stacking structure but also possesses excellent crystallinity and electron mobility in neat film. Surprisingly, the PM1 : TASe-2F2Cl -based binary organic solar cells (OSCs) yield a champion power conversion efficiencies (PCEs) of 19.32%, surpassing the PCE of 18.27%, 17.25%, and 16.30% for DASe-4F , DASe-4Cl , and TASe-2Cl2F -based devices, which attributed to the optimized blend morphology with proper phase separation and more ordered intermolecular stacking and excellent charge transport. Notably, the champion PCE of 19.32% with ultralow nonradiative recombination energy loss (Δ E 3 ) of 0.179 eV marks a record-breaking result for selenium-containing SMAs in binary OSCs. Our innovative multiple-asymmetric molecular engineering of precisely modulating the number and position of fluorinated/chlorinated end groups is an effective strategy for obtaining highly-efficient and minimal Δ E 3 of selenium-substituted SMAs-based binary OSCs simultaneously.}, archive = {J_ANGEW}, author = {Can Yang and Yuan Gao and Heng Zhang and Ze-Fan Yao and Er-Long Li and Hong-Hai Guan and Hong-Fu Zhi and Quan Yuan and Min Hun Jee and Han Young Woo and Jie Min and Jin-Liang Wang}, doi = {10.1002/anie.202506795}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506795}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple-asymmetric molecular engineering enables regioregular selenium-substituted acceptor with high efficiency and ultra-low energy loss in binary organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Beyond second coordination shell: Long-range π-electrons delocalization engineering in single-atom catalysts for CO2 electroreduction. ANGEW, 64(28), e202506663. (www)

  @article{ , abstract = {Although long-range charge delocalization beyond the second coordination shell critically influence the geometric and electronic properties of single-atom active sites, their systematic modulation to enhance multielectron catalytic processes remains largely unexplored. Here, we demonstrate a site-specific strategy to engineer the nickel tetraphenylporphyrin (NiTPP) precursors by selectively cleaving carbon–carbon single bonds at the β-carbon sites. This approach preserves the Ni-centered first and second coordination shells while systematically removing peripheral π-electron delocalization in extended coordination environments. The resultant Ni-N 4 catalyst exhibits a 29-fold enhancement in CO faradaic efficiency at −1.4 V versus RHE compared to original counterparts. Notably, it maintains 98.3% CO selectivity at industrial-grade current densities up to 500 mA cm −2 in flow cell. Combined experimental and theoretical analyses reveal that the electron-enriched Ni sites, arising from precisely regulated charge delocalization in higher coordination shells, facilitate stabilization of the critical *COOH intermediate. Our findings establish a paradigm for advanced catalyst design through deliberate engineering of higher coordination shells.}, archive = {J_ANGEW}, author = {Lingxiao Wang and Shengquan Fu and Ran Shi and Yafei Zhao and Huang Zhou and Hao Huang and Zhen-Qiang Yu and Yuen Wu}, doi = {10.1002/anie.202506663}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506663}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Beyond second coordination shell: Long-range π-electrons delocalization engineering in single-atom catalysts for CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Regulating ion transport through direct coordination in composite gel polymer electrolytes toward high-voltage and high-loading quasi-solid-state lithium metal batteries. ANGEW, 64(28), e202506662. (www)

  @article{ , abstract = {Poly(ethylene oxide)-based composite gel polymer electrolyte is widely used in lithium metal batteries to address dendrite growth and side reactions. However, the low oxidative decomposition potential (<4.0 V) of poly(ethylene oxide) limits the cyclic stability with Ni-rich layered cathodes. What's more, poor interface compatibility between fillers and polymer severely deteriorates lithium-ion pathways, which cannot achieve lithium metal batteries with high-load cathode. Herein, polyether monomers coordinate with aluminum ethoxide nanowires via in situ ultraviolet curing, stabilizing the lone pair electrons of ethereal oxygen atoms and suppressing oxidative degradation. This coordination also forms abundant and tight interfaces as the predominant lithium-ion conduction pathways, contributing to ordered lithium-ion fluxes and dendrite-free deposition on the lithium anode. In addition, a robust solid electrolyte interphase containing aluminum-based species enhances the interfacial stability of lithium anode. Meanwhile, the good compatibility between the electrolyte and the cathode effectively suppresses side reactions and contributes to the structural stabilization of the cycled cathode. The delicate design allows the Li||LiNi 0.6 Co 0.2 Mn 0.2 O 2 cells to present excellent cycling stability from −20 °C to 60 °C. Specially, cells with 8.8 mg cm −2 cathode cycle stably for over 120 cycles. This molecular structure engineering will greatly promote the practical application of solid-state lithium metal batteries.}, archive = {J_ANGEW}, author = {Siyang Ye and Yuji Zhang and Yiheng Huang and Yan Li and Zhaojie Li and Chuan Ou and Minghui Lin and Fei Tian and Danni Lei and Chengxin Wang}, doi = {10.1002/anie.202506662}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506662}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating ion transport through direct coordination in composite gel polymer electrolytes toward high-voltage and high-loading quasi-solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Harnessing negative photochromism in styryl cyanines for light-modulated proton transport. ANGEW, 64(28), e202506532. (www)

  @article{ , abstract = {Efficient photoswitches capable of complete conversion to their metastable isomer are not so common, yet highly desirable for applications in smart materials and devices. Here, we report the photochromic behavior of a series of styryl cyanine photoswitches, all demonstrating high switching efficiency, with some achieving full conversion to the metastable form. Despite structural similarities to spiropyran photoswitches, we demonstrate that the photochemistry of styryl cyanines is fundamentally different. Unlike classical photoswitches that rely on double-bond rotation, these molecules undergo substantial geometric changes via the formation of a spiro carbon. This transformation disrupts conjugation, causing a desirable blue shift in absorbance ideal for creating responsive materials and devices. We further show that the switching kinetics can be finely tuned through electronic effects of various substituents or the choice of surrounding medium. These photoswitches exhibit excellent fatigue resistance and can be easily shifted into the visible region via their acidochromic properties. Taking advantage of their high switching efficiency and affinity for acidic polymers, we finally propose their use as smart dopants to develop light-responsive materials with tunable proton transport properties under visible light irradiation.}, archive = {J_ANGEW}, author = {Gianni Pacella and Maria Nabatova and Yuxuan Zhang and David Picconi and Roza R. Weber and Shirin Faraji and Giuseppe Portale}, doi = {10.1002/anie.202506532}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506532}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing negative photochromism in styryl cyanines for light-modulated proton transport}, volume = {64}, year = {2025}, }
• (2025). Solar-blind UV organic mechanoluminescent materials. ANGEW, 64(28), e202506461. (www)

  @article{ , abstract = {Organic mechanoluminescent (ML) materials have attracted intensive attention for their potential applications in real-time stress sensing and structural damage monitoring. To avoid interference from daylight or artificial lighting sources, the ML-based sensors can be only used in dark-field scenarios, which becomes the most serious limitation for their development. Herein, we proposed a new strategy that adjusts the ML spectra to the solar-blind ultraviolet (UV) region to address this challenge. By strategically breaking the molecular conjugation and adjusting the packing mode, a series of diphenylphosphine oxide derivatives were successfully designed. To our delight, the shortest ML emission, among all reported organic ML materials, with the maxima at ca. 293 nm (in solar-blind UV region) was achieved. Photophysical studies, single crystal analysis, and theoretical calculations were performed to investigate the solar-blind UV ML properties. Furthermore, wide-range color-tunable ML emissions spanning from 293 to 741 nm were achieved. Under various external stimuli such as stretching, folding, and vehicle impact in daylight, obvious ML signals could be directly recorded, and the quantitative relationship between the mechanical stimuli and the ML intensities was also studied. This work suggests a feasible strategy to realize solar-blind UV ML materials and makes bright-field environment ML sensors possible.}, archive = {J_ANGEW}, author = {Hailan Wang and Yuxin Xiao and Shuting Kong and Yuanda Luo and Tao Yu and Wei Huang}, doi = {10.1002/anie.202506461}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solar-blind UV organic mechanoluminescent materials}, volume = {64}, year = {2025}, }
• (2025). Enantioselective decarboxylative acylation of α-hydroxy acids with carboxylic acids via Photoredox/Nickel dual catalysis. ANGEW, 64(28), e202506424. (www)

  @article{ , abstract = {Light-driven decarboxylative cross-coupling has emerged as a pivotal platform for constructing C(sp 3 )–C(sp 2 ) bonds in organic synthesis and medicinal chemistry. However, using two structurally dissimilar carboxylic acids as a feedstock to form chiral α-oxygenated ketones remains a considerable challenge due to side reactions such as decarboxylative reduction and homocoupling. Herein, we report for the first time a photoredox/nickel dual-catalyzed enantioselective decarboxylative acylation of α-hydroxy acid derivatives and aliphatic carboxylic acids, enabling efficient access to enantioenriched α-oxygenated ketones. This method exhibits a broad substrate scope, good functional group tolerance, high chemoselectivity, and excellent enantioselectivity (up to 99% e.e.). The advantage of this reaction is that it eliminates the need for metal reductants and the use of precious metal photocatalysts and utilizes renewable feedstocks. The use of a coiled-tube continuous-flow photoreactor can shorten the illumination time by half and obtain results comparable to those of a batch reaction. Furthermore, preliminary mechanistic experiments support a pathway in which photocatalytic decarboxylation generates α-oxy alkyl radical species, and the Ni(I)–alkyl intermediate activates the in situ–formed mixed anhydride followed by reductive elimination to give the product in enantiomerically pure form.}, archive = {J_ANGEW}, author = {Chen-Qiang Deng and Peng-Pai Liu and Yuantai Xu and Xue-Bin Zhang and Jin Deng and Yao Fu}, doi = {10.1002/anie.202506424}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective decarboxylative acylation of α-hydroxy acids with carboxylic acids via Photoredox/Nickel dual catalysis}, volume = {64}, year = {2025}, }
• (2025). Local atomic off-centering mediated efficient self-trapped excitonic emission in Cs5Cu3Cl6I2 nanoplates. ANGEW, 64(28), e202506404. (www)

  @article{ , abstract = {Cu(I)-based low-dimensional metal halides have received significant recognition attributable to their intriguing optoelectronic properties, which instigate the emergence of self-trapped excitons (STEs) accompanied by intense broadband emissions. However, fundamental crystal structural origin of such STE is still elusive. Herein, we have synthesized Cu(I)-based mixed halide, Cs 5 Cu 3 Cl 6 I 2 nanoplates (NPs) using room temperature ligand-assisted reprecipitation method, which showed an intense blue emission with broad line-width, large Stokes shift, long photoluminescence lifetime, high photoluminescence quantum yield (PLQY) of ∼75%. Temperature-dependent PL intensity and line-width analysis unfolded strong exciton-phonon coupling in NP sample. Synchrotron X-ray pair distribution function analysis determines the local Cu off-centering, which provides the required lattice anharmonicity and softness for intense STE in Cs 5 Cu 3 Cl 6 I 2 NPs. The existence of such soft lattice structure associated with low-energy phonons was verified by sound velocity, Raman spectroscopy and low-temperature heat capacity measurements. The fluorescence microscopy and super-resolution optical imaging were implemented at single-particle level which exhibited minimal temporal PL intermittency with reasonable photostability under high-intensity illumination. Accordingly, we hypothesize that the intense broadband emission of NPs are  accompanied by the local atomic off-centering-driven lattice deformation during photo-excitation process.}, archive = {J_ANGEW}, author = {Anustoop Das and Jayita Pradhan and Simanta Kalita and Kaushik Kundu and Paribesh Acharyya and Sarit S. Agasti and Kanishka Biswas}, doi = {10.1002/anie.202506404}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506404}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Local atomic off-centering mediated efficient self-trapped excitonic emission in Cs5Cu3Cl6I2 nanoplates}, volume = {64}, year = {2025}, }
• (2025). Mechanosensitive conjugated oligoelectrolytes for visualizing temporal changes in live cells. ANGEW, 64(28), e202506396. (www)

  @article{ , abstract = {Membrane-intercalating conjugated oligoelectrolytes (COEs) are lipid-bilayer-spanning molecules that serve as fluorescent dyes for bioimaging. However, COE emission has thus far only been capable of visualizing dye location and their preferential accumulation in different membrane-bound intracellular compartments. Herein, we report the first example of environmentally sensitive COEs for visualizing temporal changes in live cells, providing information on the physical properties of intracellular lipid bilayer membranes. The new COE-BY series is designed around a BODIPY central unit with a membrane-spanning topology and six cationic pendant groups ensuring solubility in aqueous media. These reporters feature high two-photon absorption cross section, NIR-II excitation capabilities under multiphoton excitation, and high dye brightness; all highly desirable photophysical features for bioimaging. The emission lifetime of the probes was sensitive to changes to both the lipid composition of model vesicle systems and membrane tension within cells, induced by either mechanical or osmotic stress. Using two-photon fluorescence lifetime imaging microscopy, it is possible to use the most efficient emitter, namely, COE-BYPhOC4 , to image changes in the mechanical properties of intracellular membranes. We show that these COEs remain stably vesicle-bound within the endolysosomal pathway over extended periods, allowing for long-term monitoring of the associated biophysical changes of these vesicles over time.}, archive = {J_ANGEW}, author = {Ji-Yu Zhu and Samuel J. W. Chan and Hongyue Cui and Alexander A. Mikhalovsky and Fernando L. Garcia and Brandon Yeow Wee Goh and Wilson Wee Mia Soh and Alex S. Moreland and Jakkarin Limwongyut and Sukanya Shyamasundar and Ya Jun Wu and Fengyi Liang and Rong Li and Guillermo C. Bazan}, doi = {10.1002/anie.202506396}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506396}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanosensitive conjugated oligoelectrolytes for visualizing temporal changes in live cells}, volume = {64}, year = {2025}, }
• (2025). P–π conjugation-promoted electrochemiluminescence of halogenated covalent organic framework nanoemitters. ANGEW, 64(28), e202506309. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) are a kind of promising electrochemiluminescence (ECL) crystalline nanoemitters due to their rapid intrareticular charge transfer and predesigned structures. However, the high polarization of heteroatom-containing linkages impedes the charge transfer within reticular structures. In this study, we construct a series of halogenated COFs nanoemitters composed of terephthalaldehyde ortho-substitutions and 1,3,6,8-tetrakis(4-aminophenyl)pyrene ligands via a covalent halogenation predesign strategy. The incorporation of covalently bonded halogen atoms promotes a dense electron population in carbon–carbon antibonding molecular orbitals, thereby facilitating efficient p–π conjugation within the COF structure. Based on the improved intrareticular charge transfer along carbon skeleton, as evidenced by the Hall effect and terahertz spectroscopy, the brominated COF demonstrates a 49-fold enhancement in ECL intensity compared to nonhalogenated COF. Furthermore, the performance of four partially brominated COFs establishes a positive correlation between the degree of Br doping and ECL intensity. Beyond the corresponding model compounds, the conjugated frameworks of COFs significantly amplify the halogenation-induced enhancement effect. This halogenation-promoted p–π conjugation in reticular skeleton provides a universal strategy to sensitize crystalline nanoemitters for decoding ECL enhancement mechanism.}, archive = {J_ANGEW}, author = {Hanlin Hou and Yuting Wu and Jiacheng Wan and Rengan Luo and Lina Wu and Yanli Zhao and Xiaojun Wu and Jianping Lei}, doi = {10.1002/anie.202506309}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506309}, shortjournal = {Angew. Chem. Int. Edit.}, title = {P–π conjugation-promoted electrochemiluminescence of halogenated covalent organic framework nanoemitters}, volume = {64}, year = {2025}, }
• (2025). Visible light excited time-dependent phosphorescence color tuning in carbon dots via charge transfer. ANGEW, 64(28), e202506162. (www)

  @article{ , abstract = {Achieving high-efficiency time-dependent phosphorescence color (TDPC) materials that can be activated under visible light with strong stability remains challenging. In this study, carbon dots (CDs) were confined in the boric acid matrix to activate surface crosslinking emissive clusters and modulate charge transfer (CT) interaction, facilitating green and red dual emissive centers to coexist in composites. The presence of halogen atoms strengthened the interactions between CDs and boric acid. Notably, the CT interaction can offer excitons at low energy levels and allow for a much lower energy requirement for charge separation, making the red emissive center more dominant under visible light excitation. The interplay of dual centers featuring sufficient color differentiation and different decay rates activated characteristic TDPC evolution resulting in dynamic afterglow evolution from red to white under visible light excitation. Moreover, the formation of rigid boric acid crystalloid network resulted in an ultra-strong confinement at high temperature, enabling the composites to emit long persistent afterglow at high temperatures of up to 393 K under visible light excitation. The study provides new light on the design of TDPC materials and represents a significant advancement toward expanding the application in information security.}, archive = {J_ANGEW}, author = {Yingying Bi and Jingkun Yu and Jiping Xiao and Kai Zhu and Boyang Wang and Xiaokai Xu and Siyu Lu}, doi = {10.1002/anie.202506162}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible light excited time-dependent phosphorescence color tuning in carbon dots via charge transfer}, volume = {64}, year = {2025}, }
• (2025). Nucleophilic germylation of stable π bonds via Ge─Ge bond heterolysis. ANGEW, 64(28), e202506106. (www)

  @article{ , abstract = {Organogermanes have recently attracted a great deal of attention as building blocks for the synthesis of bioactive products, drugs, and functional materials. Metallo-germyls were classically synthesized and employed for nucleophilic germylation to form C─Ge bonds. However, their syntheses require highly reactive organometal reagents, and the scope of germylations involving metallo-germyls is limited due to competition with kinetically favored side reactions. Here, we present a regio/stereo-convergent nucleophilic germylation of stable π bonds by germyl anion generated in situ via heterolytic cleavage of the Ge─Ge bond of digermane (Ge─Ge) in the presence of KO t Bu. This methodology affords unprecedented reactivity, enabling multiple germylation of alkynes and internally selective germylation of alkenes. These reactions are operationally simple, have broad functional group tolerance, and afford densely functionalized aliphatic organogermanes, such as 1-alkyl-1-germylalkanes, 1,1-digermylalkanes, and 1,1,1-trigermylalkanes, without any catalyst.}, archive = {J_ANGEW}, author = {Kyoka Sakamoto and Yuki Nagashima and Shinichiro Kamino and Masanobu Uchiyama}, doi = {10.1002/anie.202506106}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506106}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nucleophilic germylation of stable π bonds via Ge─Ge bond heterolysis}, volume = {64}, year = {2025}, }
• (2025). Interweaving covalent organic polymer chains into two-dimensional networks: Synthesis, single crystal structure, and application for stabilizing lithium metal anode. ANGEW, 64(28), e202506036. (www)

  @article{ , abstract = {Macroscopic weaving has been proven to be the most enduring and effective method for manufacturing fabrics to meet the practical needs of humanity for thousands of years. However, the construction of molecular structures with exquisite topologies and specific properties based on molecular weaving is still in its infancy. Herein, we designed and fabricated a two-dimensional (2D) woven covalent organic polymer (COP) network (named as CityU-46 ) driven by the dative N→B bonds between the 1,4-bis(benzodioxa-borole)benzene (BACT) and 2,5-bis(4-pyridyl)-1,3,4-thiadiazole (BPT). The complex woven topology of CityU-46 was determined using a single-crystal X-ray diffraction technique, revealing that it features a well-defined two-over and two-under interweaving pattern at the molecular level. Due to its structural merits, CityU-46 can be used as an artificial organic solid-electrolyte interphase layer on the surface of Li metal anodes, significantly improving the stability and long-term performance of lithium metal cells.}, archive = {J_ANGEW}, author = {Lizhong He and Tuoya Naren and Lei Zhang and Fangyuan Kang and Jinglun Yang and Zihao Chen and Aimin Yu and Dong-Sheng Li and Libao Chen and Qichun Zhang}, doi = {10.1002/anie.202506036}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506036}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interweaving covalent organic polymer chains into two-dimensional networks: Synthesis, single crystal structure, and application for stabilizing lithium metal anode}, volume = {64}, year = {2025}, }
• (2025). Activating surface oxygen in Ce/Mo-doped ni oxyhydroxide for synergistically enhancing furfural oxidation and hydrogen evolution at ampere-level current densities. ANGEW, 64(28), e202506017. (www)

  @article{ , abstract = {The integration of biomass-platform molecule oxidation with water electrolysis is a promising strategy to reduce energy consumption in hydrogen production and obtain high-value chemicals simultaneously, yet the efficiency of organic oxidation requires further improvement. Herein, we developed a highly efficient Ce, Mo co-doped Ni-based (oxy)hydroxide catalyst, where Mo with high spin state promotes the adsorption of furfural (FA), while Ce activates surface lattice oxygen (O L ), lowering the energy barrier for O L ─OH coupling to form OOH, the key intermediate for high current densities. The catalyst achieves an industrial-grade current density of 1000 mA cm − 2 at a remarkably low potential of 1.46 V versus RHE in furfural oxidation, with exceptional selectivity (99.4%) and Faradaic efficiency (97.7%) for furoic acid. When deployed as anode in an anion-exchange membrane reactor, the NiMoCe/NF catalyst sustains a current density of 500 and 1000 mA cm − 2 at a cell voltage of only 1.85 and 2.15 V, respectively, surpassing most reported continuous flow electrolyzers limited to 200 mA cm − 2 . Moreover, the system exhibits outstanding durability after 200 h of continuous operation. This work provides critical insights into the rational design of catalysts for energy-efficient biomass valorization coupled with industrial hydrogen production.}, archive = {J_ANGEW}, author = {Tian Cao and Jia Cheng and Yang Xiang and Linping Hu and Xiaohua Hu and Li Li and Xun Huang and Zidong Wei}, doi = {10.1002/anie.202506017}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202506017}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activating surface oxygen in Ce/Mo-doped ni oxyhydroxide for synergistically enhancing furfural oxidation and hydrogen evolution at ampere-level current densities}, volume = {64}, year = {2025}, }
• (2025). Triple-phase boundaries enable selective urea production from simulated flue gas in a zero-gap electrolyzer. ANGEW, 64(28), e202505987. (www)

  @article{ , abstract = {Renewable energy-powered co-electrolysis of CO 2 and NO 3 − offers a promising pathway toward sustainable urea production. However, achieving high urea selectivity is challenging due to substantial competing side reactions. Here, we show that engendering a high density of CO 2 bubbles on the catalyst surface creates numerous triple-phase boundaries that are key toward enhancing CO 2 versus NO 3 − availability for selective urea production. We implemented this strategy using a bipolar membrane in a zero-gap electrolyzer, which allows for the in situ conversion of (bi)carbonate to CO 2 bubbles at the catalyst/electrolyte interface. Notably, we demonstrate that this electrolyzer system can utilize simulated flue gas (20% CO 2 + 5% O 2 ) for urea production. With a Cu 95 Ru 5 catalyst, we achieve a urea Faradaic efficiency of 58% at 2 V full-cell voltage over an extended 30-h period and a peak production rate of 35.46 mmol h −1 g cat −1 . Under these conditions, the Faradaic efficiency to hydrogen evolution and nitrate reduction are 14.7% and 21.6%, respectively. Strikingly, these results with simulated flue gas are comparable to previously reported systems that employ pure CO 2 . Our results introduce a simple yet effective design approach toward developing efficient electrolyzer systems for urea production.}, archive = {J_ANGEW}, author = {Meng Wang and Chenxi Luo and Ziyu Mi and Yu-Chia Chang and Yu-Ting Chueh and Ping Luo and Mingsheng Zhang and Jiguang Zhang and Ruoou Yang and Qin Yang and Sibo Wang and Shuo Chen and Jinfeng Jia and Wan Ru Leow and Zainul Aabdin and Sung-Fu Hung and Yanwei Lum}, doi = {10.1002/anie.202505987}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505987}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triple-phase boundaries enable selective urea production from simulated flue gas in a zero-gap electrolyzer}, volume = {64}, year = {2025}, }
• (2025). Synthesis and modification of formate zr-MOF (ZrFA) toward scalable and cost-cutting gas separation. ANGEW, 64(28), e202505978. (www)

  @article{ , abstract = {The mass production of metal-organic frameworks (MOFs) with affordable cost is highly demanding yet limited for commercial applications, e.g., purification of polymer-grade ethylene (C 2 H 4 ) via acetylene (C 2 H 2 ) and carbon dioxide (CO 2 ) removal faces the challenge of developing low-cost and large-scale physisorbents with efficiency and recyclability. Herein, we developed a viable synthetic protocol to scale-up a series of ultramicroporous Zr-MOFs (ZrFA/ZrFA-D/ZrFA-D-Cu(I)) with the simplest monocarboxylate, formate (FA), through consecutive production by recycling solvent/modulator. Besides a size-exclusion effect disfavoring C 2 H 4 adsorption, introduction of defective and Cu(I) sites was found to enhance gas affinity and uptake capacity. A comprehensive evaluation of C 2 H 4 separation and economic efficiency has been proposed, suggesting the improvement of C 2 H 2 uptake capacity is effective for the binary C 2 H 2 /C 2 H 4 separation, while the separation process of the ternary C 2 H 2 /CO 2 /C 2 H 4 mixtures depends on subtle tradeoff of complex factors and limited by challenging CO 2 /C 2 H 4 separating. Notably, the large-scale separation has been testified to significantly improve separation efficiency, and the low-cost preparation benefits high economic efficiency. The distinct C 2 H 2 /C 2 H 4 /CO 2 adsorption mechanism in ZrFA/ZrFA-D/ZrFA-D-Cu(I) has been elucidated by the theoretical calculations. This work may shed a light on the future C 2 H 4 purification technology by pushing MOF-syntheses toward low-cost, scale-up, and recyclable production.}, archive = {J_ANGEW}, author = {Xiao-Hong Xiong and Liang Song and Wei Wang and Xiao-Yan Zhu and Liu-Li Meng and Hui-Ting Zheng and Zhang-Wen Wei and Li-Lin Tan and Xiao-Chun Huang and Cheng-Yong Su}, doi = {10.1002/anie.202505978}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and modification of formate zr-MOF (ZrFA) toward scalable and cost-cutting gas separation}, volume = {64}, year = {2025}, }
• (2025). Machine learning reveals in-cavity versus surface activity for selective C─H borylation by metal-organic framework catalysts. ANGEW, 64(28), e202505931. (www)

  @article{ , abstract = {Metal-organic frameworks (MOFs) provide an expansive and tunable platform for heterogeneous catalysis, yet distinguishing between catalytic reactions occurring within their pores and those on their external surfaces remains a challenge. This study employs interpretable machine learning to elucidate structure-activity relationships in MOF-supported nickel (Ni) catalysts for selective sp 3 and sp 2 C─H borylation. By analyzing over 470 000 MOF structures, we developed a set of 45 concise and chemically meaningful descriptors that capture key structural variations across MOFs. These descriptors enabled us to identify the critical factors governing sp 3 versus sp 2 selectivity, revealing distinct activation mechanisms: sp 3 C─H borylation preferentially occurs within MOF cavities via a radical-mediated hydrogen atom transfer (HAT) mechanism, whereas sp 2 C─H borylation is associated with surface or defect sites, favoring a concerted metalation-deprotonation (CMD) pathway. Guided by these insights, we designed Ni catalysts that achieve up to 97.8% sp 3 selectivity and 88.7% sp 2 selectivity. This work provides a systematic framework for rational catalyst design and establishes generalizable principles for controlling activity preference in MOF-supported catalysis.}, archive = {J_ANGEW}, author = {Zhaomin Su and Bingling Dai and Xue Wang and Yibin Jiang and Wenbin Lin and Cheng Wang}, doi = {10.1002/anie.202505931}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505931}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning reveals in-cavity versus surface activity for selective C─H borylation by metal-organic framework catalysts}, volume = {64}, year = {2025}, }
• (2025). Evoking simultaneous ferroptosis and apoptosis by a dual-locked platinum (IV) prodrug for synergistic chemo-immunotherapy. ANGEW, 64(28), e202505930. (www)

  @article{ , abstract = {While platinum-based chemotherapeutics have revolutionized cancer treatment, their clinical potential is limited by off-target toxicity and restricted antitumor mechanisms. Herein, we introduce a dual-locked Pt(IV) prodrug designed for tumor-specific activation, combining platinum-based chemotherapy with TLR7/8-mediated immunotherapy. The prodrug features a γ-glutamyl-caged TLR7/8 agonist as an axial ligand, enabling sequential activation by elevated glutathione (GSH) and γ-glutamyltranspeptidase (GGT) in the tumor microenvironment. Reduction of the Pt(IV) core releases cisplatin and depletes intracellular reductants, amplifying reactive oxygen species to trigger synergistic ferroptosis and apoptosis. Concurrently, GGT-cleaved axial ligand activates tumor-associated macrophages and dendritic cells, repolarizing immunosuppressive M2-like macrophages to pro-inflammatory M1-like phenotypes while recruiting effector and memory T cells. In murine models, the Pt(IV) prodrug demonstrated potent antitumor efficacy by confining immune activation to malignant tissues, eradicating primary tumors, and establishing durable protective immunity against recurrence. This spatiotemporally controlled dual-release strategy minimizes systemic toxicity while synergizing chemotherapy and immunotherapy, offering a transformative approach for targeted cancer therapy.}, archive = {J_ANGEW}, author = {He Meng and Jinhui Wang and Hongyu Wen and Zilong Xu and Liuruiqi Luo and Wenkai Lin and Kai Lu and Yuxiang Lu and Jing Wang and Yufang Xiong and Jianqiao Xu and Zong-Wan Mao and Wei Xia}, doi = {10.1002/anie.202505930}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505930}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evoking simultaneous ferroptosis and apoptosis by a dual-locked platinum (IV) prodrug for synergistic chemo-immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Bromide as noninnocent ligand to iron tames fenton chemistry for chemoselective nondegrading oxidation. ANGEW, 64(28), e202505907. (www)

  @article{ , abstract = {It has long been the chemistry dogma that the nitrogen-based ligand of iron complexes determines the redox reactivity; tetra- and/or pentadentate nitrogen-based ligand ( N -ligand: PDP, porphyrin, N4Py) enables chemo-selective oxidation through high-valent iron species (Fe IV/V ═O), while bi- and/or tridentate N -ligand leads to the generation of highly reactive oxygen species (ROS) (i.e., hydroxyl radical) via a Fenton chemistry pathway. The effect of inorganic anionic ligands (i.e., halides, pseudohalides, triflate, nitrate, sulfate, etc ) of these iron complexes has rarely been examined and overlooked as an “innocent” anion. Herein, we report our discovery that bromide (Br − ) is not an innocent ligand to the iron-BPMA complexes [BMPA: bis(2-pyridylmethyl)amine] but a decisive factor for taming the Fenton chemistry (ROS) into a mild [HOBr] oxidant, which allows for chemo- and regioselective oxidation of furans, indoles, and sulfides without noticeable degradation. In contrast to the conventional Fenton chemistry pathway by many tridentate N -ligand iron complexes, our [Fe(BMPA)Br 3 ] mimics haloperoxidases to generate HOBr by oxidation of bromide ion with hydrogen peroxide. The discovery of the bromide effect on iron complexes bridges the gap between Fenton chemistry and haloperoxidase-catalyzed halogenation and might stimulate interest in reinvestigating the “innocent” ligand of iron complexes for discovery of new reactivity and new applications. Additionally, the new catalytic system represents a mild and green oxidation method that might be useful in academia and industry.}, archive = {J_ANGEW}, author = {Guodong Zhao and Kang Xue and Huiling Dong and Shaoyan Lou and Xiaohui Zhang and Zhuo Cao and Bingqing Yi and Rongbiao Tong}, doi = {10.1002/anie.202505907}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505907}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bromide as noninnocent ligand to iron tames fenton chemistry for chemoselective nondegrading oxidation}, volume = {64}, year = {2025}, }
• (2025). P-type cathode material design guided by material descriptors for high-energy density sodium batteries. ANGEW, 64(28), e202505831. (www)

  @article{ , abstract = {P-type organic electrode materials (OEMs) face considerable challenges in constructing high-energy density sodium metal batteries (SMBs) due to their low capacity. To preserve their voltage advantage, developing effective structural design strategies is essential. However, the lack of material descriptors hampers the efficiency of material design and screening. Herein, two material descriptors: the benzene ring/active nitrogen (R/N) ratio and energy density factor (E f ) are established to guide high-energy density SMB design. As proof of concept, triphenylamine (TPA, 3 R/N ratio and 573.6 E f value) and a porous organic polymer condensation of triiodotriphenylamine and dihydrophenazine named p-PZA POP (1.5 R/N ratio and 907.5 E f value) are chosen. As a result, the p-PZA POP achieves a high energy density of 524.6 Wh kg −1 at 1 A g −1 , nearly double that of TPA (273.3 Wh kg −1 ). Remarkably, p-PZA POP demonstrates excellent wide-temperature electrochemical performance from 50 °C (166.2 mAh g −1 at 1 A g −1 ) to −20 °C (141.6 mAh g −1 at 0.1 A g −1 ). This work establishes a theoretical framework for the rational design and screening of high-performance p-type OEMs through predictive material descriptors.}, archive = {J_ANGEW}, author = {Weijia Zhang and Tianjiang Sun and Weichao Cheng and Mengyao Shi and Min Cheng and Qiong Sun and Jianfei Su and Xiulan Li and Zhanliang Tao}, doi = {10.1002/anie.202505831}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505831}, shortjournal = {Angew. Chem. Int. Edit.}, title = {P-type cathode material design guided by material descriptors for high-energy density sodium batteries}, volume = {64}, year = {2025}, }
• (2025). Covalent organic framework nanosheets for the assembly of efficient membrane bioreactors. ANGEW, 64(28), e202505797. (www)

  @article{ , abstract = {Immobilizing fragile enzymes in porous materials holds significant potential for biocatalysis but encounters challenges such as mismatched enzyme size and pore structure of host materials, along with harsh assembly conditions that can denature enzymes. Herein, we present a versatile strategy for constructing membrane bioreactors through water-mediated, vacuum-assisted layer-by-layer assembly of covalent organic framework (COF) nanosheets with enzymes. This method effectively addresses pore size limitations, preserves enzyme activity, and promotes convective transport of reactants to active sites, while shielding enzymes from harmful by-products through rapid transport in continuous membrane catalysis. The optimized bioreactor achieves a 1018-fold increase in relative activity compared to free enzymes in batch reactions, completing substrate conversion in just 7.95 s, and demonstrating enhanced stability.}, archive = {J_ANGEW}, author = {Jingxu Han and Zhiwei Xing and Qing Guo and Di Wu and Zhuozhi Lai and Xiaoxiao Cheng and Zhifeng Dai and Yubing Xiong and Xiangju Meng and Shengqian Ma and Feng-Shou Xiao and Qi Sun}, doi = {10.1002/anie.202505797}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505797}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent organic framework nanosheets for the assembly of efficient membrane bioreactors}, volume = {64}, year = {2025}, }
• (2025). Modulation of photoluminescence of BODIHY dye using water-soluble coordination cages with different shapes. ANGEW, 64(28), e202505772. (www)

  @article{ , abstract = {The confinement of guest molecules within supramolecular hosts can alter their photophysical properties. However, the shapes of the hosts in regulating the guest's emission remains underexplored. Herein, we investigate how the shape of the host alters the emission behavior of boron difluoride hydrazone (BODIHY) ( G 1 ) dye encapsulated within two iso-stoichiometric water-soluble coordination cages: MC1 (double-square cage) and MC2 (octahedral cage). Encapsulation of G 1 within MC1 results in a highly emissive solution, whereas similar confinement in MC2 leads to a non-emissive host–guest solution. A similar trend was observed with different sets of iso-stoichiometric cages MC3 (double-square cage) and MC4 (octahedral cage). Using a combination of femtosecond transient absorption and time-resolved fluorescence spectroscopy, we observed that the disparity in fluorescence behavior of BODIHY is attributed to charge transfer interactions between the guest and ligand panels of cages. The shape of the coordination cage dictates the preorganization of the guest within the cavity, thereby suppressing or promoting this charge transfer interactions. Moreover, we demonstrate a turn-on emission of BODIHY dye due to its preferential binding to a double-square cage. These findings provide fundamental insights into host-mediated modulation of the guest's photophysics and offer a blueprint for designing supramolecular systems with tunable emissive behavior.}, archive = {J_ANGEW}, author = {Valiyakath Abdul Rinshad and Prajoy Kumar Mitra and Sailendra Pradhan and Yapamanu Adithya Lakshmanna and Partha Sarathi Mukherjee}, doi = {10.1002/anie.202505772}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulation of photoluminescence of BODIHY dye using water-soluble coordination cages with different shapes}, volume = {64}, year = {2025}, }
• (2025). Spatially engineering the internal microstructure of a single crystal via nanoparticle occlusion. ANGEW, 64(28), e202505637. (www)

  @article{ , abstract = {Single crystals are characterized by their continuous, highly ordered atomic lattices. Therefore, introducing impurities or structural defects into their matrices presents a major challenge, particularly in a spatially-controlled manner. Herein, we demonstrate a nanoparticle occlusion approach that enables the microstructure of cuprous oxide (Cu 2 O) single crystals to be engineered in a tunable way. This is achieved by directly incorporating poly(glycerol monomethacrylate) 51 - block -poly(benzyl methacrylate) 100 [G 51 -B 100 ] diblock copolymer nanoparticles into growing Cu 2 O crystals, leading to the formation of G 51 -B 100 @Cu 2 O composite crystals with structural defects localized at the G 51 -B 100 /Cu 2 O interfaces. The spatial distribution of these defects can be systematically engineered, ranging from the surface region to the entire crystal. Remarkably, the G 51 -B 100 occlusion endows the resulting composite crystals with excellent catalytic performance in dye degradation under dark conditions, with activity correlated to the extent of nanoparticle occlusion. This study offers a unique strategy to create interfacial defects in single crystals, imparting emerging functionalities to the resulting composites.}, archive = {J_ANGEW}, author = {Bing Yu and Pei Liu and Jingjing He and Xiaojie Li and Xia Sun and Boxiang Peng and Jiahao Zhang and Yin Ning}, doi = {10.1002/anie.202505637}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatially engineering the internal microstructure of a single crystal via nanoparticle occlusion}, volume = {64}, year = {2025}, }
• (2025). On the mechanism of soft self-assembly from melt: The ubiquitous heat capacity hump and spontaneous melt chirality. ANGEW, 64(28), e202505548. (www)

  @article{ , abstract = {We investigate two unusual phenomena in self-assembly of anisotropic molecules from isotropic (Iso) melt: a heat-capacity ( C p ) maximum and spontaneous formation of the recently discovered chiral liquid (Iso*). Based on experiments on new nonchiral monomers, dimers, and polymers, we construct a statistical theory that shows why many complex meso-structures form in two stages: continuous equilibrium growth of nano-clusters in melt through strong interactions, causing the C p -maximum, followed by establishment of positional long-range order (LRO) through a weak first-order transition. We also show why many achiral compounds additionally form an intermediate chiral Iso* liquid through what we find is a second-order transition. We propose that the first process is equivalent to “supramolecular polymerization” in solutions, where the lack of intercluster interaction rules out LRO. Furthermore, we argue that separation into a broad and a sharp transition is universal in condensed matter where strong interactions by themselves cannot lead to LRO, either because the clusters are 1D or due to strong frustration. Clusters must first grow to critical size when, at T c , the combined weak interactions reach ∼k B T c , prompting LRO formation. A situation similar to that in soft self-assembly is seen in spin ordering in magnetic crystals, but only near 0 K.}, archive = {J_ANGEW}, author = {Yi-nan Xue and Xiang-bing Zeng and Bo-wen Wu and Ya-xin Li and Liliana Cseh and Shu-gui Yang and Jie Liu and Gillian A. Gehring and Feng Liu and Goran Ungar}, doi = {10.1002/anie.202505548}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505548}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On the mechanism of soft self-assembly from melt: The ubiquitous heat capacity hump and spontaneous melt chirality}, volume = {64}, year = {2025}, }
• (2025). Photoelectrocatalytic activation of C─H bond in toluene by titanium dioxide-supported subnanometric PtOx clusters. ANGEW, 64(28), e202505544. (www)

  @article{ , abstract = {Selective oxidation of C(sp 3 )─H bonds via photoelectrocatalytic (PEC) strategy provides a promising approach to synthesize valuable oxygenates, but the efficiency of this process is still unsatisfactory due to the stable nature of hydrocarbon molecules. Herein, we report the PEC oxidation of toluene to benzaldehyde (BA) over a subnanometric PtO x cluster-loaded TiO 2 (PtO x /TiO 2 ) photoanode, achieving BA production rate of 1.75 µmol cm ‒2 h ‒1 with selectivity of 83.5% in aqueous medium, which is 4.4-fold higher than that of pristine TiO 2 . The strategy is also effective for the selective oxidation of toluene derivatives. As a proof-of-concept, we fabricate a self-powered PEC tandem device with S-shaped flow channels for the oxidation of toluene, producing BA with a productivity of ∼170 µmol under light irradiation. Experimental studies combined with density functional theory (DFT) results demonstrate that the toluene oxidation over PtO x /TiO 2 photoanode follow an electrophilic hydroxyl species (OH*)-mediated pathway, which can suppress the over-oxidation of BA. Moreover, we reveal that subnanometric PtO x clusters promote toluene adsorption and OH* species generation, leading to the high efficiency of toluene oxidation. This work is expected to broaden the avenue toward the activation of C(sp 3 )─H bond under mild conditions in aqueous solution via a sustainable way.}, archive = {J_ANGEW}, author = {Lan Luo and Yu-Quan Zhu and Wangsong Chen and Yucong Miao and Shanshan Zhang and Yusen Yang and Zhenhua Li and Mingfei Shao}, doi = {10.1002/anie.202505544}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505544}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoelectrocatalytic activation of C─H bond in toluene by titanium dioxide-supported subnanometric PtOx clusters}, volume = {64}, year = {2025}, }
• (2025). Access to N-monofluoromethylated (Thio)Carbamates, formamides, alkynamides, and related derivatives. ANGEW, 64(28), e202505478. (www)

  @article{ , abstract = {This work presents the first general synthetic access to N -CH₂F and N -CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds. The synthetic approach employs N -CH 2 F and N -CHRF carbamoyl fluorides as versatile strategic building blocks, which can be efficiently synthesized in a single step directly from readily available amines or imines.}, archive = {J_ANGEW}, author = {Filip G. Zivkovic and Fritz Bahns and Che-Ming Hsu and Franziska Schoenebeck}, doi = {10.1002/anie.202505478}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505478}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Access to N-monofluoromethylated (Thio)Carbamates, formamides, alkynamides, and related derivatives}, volume = {64}, year = {2025}, }
• (2025). Enantioselective palladium-catalyzed α-arylation of acyclic esters. ANGEW, 64(28), e202505458. (www)

  @article{ , abstract = {A Pd-catalyzed enantioselective α-arylation of α,α-disubstituted esters with aryl bromides is established for the first time by employing P-chiral monophosphorus ligand 3-Pent-BIDIME as a chiral ligand, leading to a series of enantioenriched α,α-diaryl esters possessing quaternary carbon stereocenters in moderate to good yields and high enantioselectivities. The method features a broad substrate scope, mild conditions, excellent functional group compatibility, and low Pd loadings (as low as 1 mol%). The synthetic power of this protocol is exemplified by the efficient preparation of a chiral α,α-diaryl substituted γ-lactone and asymmetric synthesis of ( R )-amolanone. DFT calculation revealed an NaBr-bridged downstream transmetallation and the importance of noncovalent interaction in controlling the enantioselectivity.}, archive = {J_ANGEW}, author = {Jianxun Huang and Chao Pei and He Yang and Bin Wu and Wenjun Tang}, doi = {10.1002/anie.202505458}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505458}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective palladium-catalyzed α-arylation of acyclic esters}, volume = {64}, year = {2025}, }
• (2025). Development of an organoautocatalyzed double σ-bond c(sp2)-N transamination metathesis reaction. ANGEW, 64(28), e202505275. (www)

  @article{ , abstract = {The transamination reaction, which involves the conversion of one amine to another, traditionally relies on biological enzyme catalysts. Although chemists have recently developed a few transition metal-catalyzed methods, mimicking these enzymes to interconvert amine groups in acyclic substrates via transamination metathesis of a single C(sp 2 )─N bond, transamination of cyclic tertiary amines has remained a challenge in synthetic chemistry. Here, we present the development of organoautocatalyzed transamination metathesis of two C(sp 2 )─N bonds in a cyclic substrate that allows for the challenging transformation to take place with up to 95% yield under exceptionally mild reaction conditions at room temperature without external catalysts and/or additives. The reaction mechanism has been studied in detail through time-resolved 1 H-NMR, 2D NMR, and computational methods. Remarkably, in situ-formed pyrrolidinium salt acts as a hydrogen bond donor (HBD) organoautocatalyst in this multi-step domino process. The new organoautocatalyzed methodology gives environmentally friendly, atom-economical, straightforward, and rapid access to N -substituted 3,5-dinitro-1,4-dihydropyridines (DNDHPs), thus offering facile entry to privileged bioactive compounds.}, archive = {J_ANGEW}, author = {Volker Klein and Florian Schuster and Jonas Amthor and Harald Maid and Prabhakar Bijalwan and Fahmi Himo and Stefano Santoro and Svetlana B. Tsogoeva}, doi = {10.1002/anie.202505275}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505275}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development of an organoautocatalyzed double σ-bond c(sp2)-N transamination metathesis reaction}, volume = {64}, year = {2025}, }
• (2025). Defect-triggered orbital hybridization in FeMn dual-atom catalysts toward sabatier-optimized oxygen reduction. ANGEW, 64(28), e202505268. (www)

  @article{ , abstract = {Dual single-atom catalysts (DSAs), leveraging synergistic dual-site interactions, represent a promising frontier in electrocatalysis. However, the precise synthesis of dual-atom pairs and fine-tuning of their electronic structures remain significant challenges. Herein, we construct a defect-engineered heteronuclear FeMn-DSA anchored on a porous nitrogen-doped carbon matrix (FeMn D SA / d NC) through a customized trinuclear-defect trapping strategy. This defect modulation strategy effectively stabilizes dual atomic pairs while optimizing electronic structures to approach Sabatier's optimality, significantly boosting oxygen reduction reaction (ORR) performance. The FeMn D SA / d NC achieves a high half-wave potential of 0.921 V in alkaline media, with assembled zinc-air batteries demonstrating 291 mW cm −2 peak power density and stable charge/discharge cycling for over 500 h. Theoretical calculations reveal that defect-mediated coordination adjacent to Fe-Mn diatomic centers triggers charge redistribution, suppressing antibonding orbital populations while strengthening Fe 3 d z 2 with O 2p orbital hybridization. This modulation weakens O─O bonding through optimized * OOH adsorption configurations, thereby enhancing ORR kinetics. The present work provides valuable insights into the precise modulation and the underlying mechanisms of DSAs, advancing the design of electrocatalysts for energy storage and conversion applications.}, archive = {J_ANGEW}, author = {Mengxin Liu and Ying Li and Liu Yang and Pengcheng Zhao and Jingshuai Li and Lingtong Tian and Dapeng Cao and Zhongwei Chen}, doi = {10.1002/anie.202505268}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505268}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Defect-triggered orbital hybridization in FeMn dual-atom catalysts toward sabatier-optimized oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). Nucleophilic covalent ligands enable simultaneous surface reconstruction and passivation of colloidal InSb quantum dots for stable short-wave infrared photodetectors. ANGEW, 64(28), e202505179. (www)

  @article{ , abstract = {Indium antimonide (InSb) colloidal quantum dots (CQDs) are promising candidates for short-wave infrared (SWIR) photodetectors due to their large Bohr exciton radius and tunable bandgap in the 0.6–1.3 eV range. However, the formation of metal oxides on InSb surfaces during synthesis impedes charge transport, necessitating CQD resurfacing strategies for integration into photodetectors. Previous reports achieved progress in device efficiency by resurfacing these CQDs with acid-halide sequential treatments, but the device operating stability remains unsatisfactory. Herein, we report a solution-phase strategy for surface reconstruction and passivation of InSb CQDs using sulfur-based nucleophilic covalent ligands. We find that short-chain thiol molecules remove surface metal oxides through nucleophilic attack and enable robust passivation of In and Sb via strong covalent bonds, whereas metal sulfides are less effective at oxide removal and passivation. Consequently, the thiolate-passivated CQDs exhibit a tenfold decrease in trap state density compared to controls and remain structurally and optically stable for 5 months. We demonstrate InSb CQD SWIR photodetectors that realize a high external quantum efficiency (EQE) of 28% at 1450 nm, with the highest operating stability among reported CQD SWIR photodetectors, retaining 95% of performance following 300 h of biased and illuminated operation.}, archive = {J_ANGEW}, author = {Yangning Zhang and Muhammad Imran and Pan Xia and Yiqing Chen and Ahmet Gulsaran and Yanjiang Liu and Ehsan Nikbin and Benjamin Rehl and Lizhou Fan and Filip Dinic and Da Bin Kim and Lewei Zeng and Mustafa Yavuz and Sjoerd Hoogland and Edward H. Sargent}, doi = {10.1002/anie.202505179}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nucleophilic covalent ligands enable simultaneous surface reconstruction and passivation of colloidal InSb quantum dots for stable short-wave infrared photodetectors}, volume = {64}, year = {2025}, }
• (2025). Rhodium/Indium heterobimetallic alloy as an effective catalyst for reductive C(sp3)─O silylation of ethers with chlorosilanes. ANGEW, 64(28), e202505028. (www)

  @article{ , abstract = {C(sp 3 )─O bonds are ubiquitous in natural and synthetic small molecules as well as polymers. The methodology for functionalizing C(sp 3 )─O bonds is of great importance for reforming these molecular structures into high-value-added chemical feedstocks. Here, we describe the reductive C(sp 3 )─O bond silylation of ethers with chlorosilanes and magnesium reductants by cooperative rhodium and indium catalysis. This methodology allows the incorporation of silyl moieties into the C(sp 3 )─O bond of various unactivated cyclic and acyclic alkyl ethers using chlorotriorganosilanes. Not only the mixture of rhodium complex with indium reagent but also rhodium nanoparticles supported on indium oxide showed high catalytic activity, indicating a remarkable cooperative effect by the two metals. Notably, in both cases, the generation of rhodium/indium heterobimetallic alloy nanoparticles was revealed by mechanistic studies including XRD, XAS, and TEM imaging. This research advances the development of heterogeneous nanoparticle catalysts as an option to enable organic transformations that have not yet been achieved using homogeneous catalysts.}, archive = {J_ANGEW}, author = {Rin Seki and Haruka Kido and Kana Ko and Kaoru Imoto and Hiroki Miura and Tetsuya Shishido and Yoshiaki Nakao}, doi = {10.1002/anie.202505028}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505028}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhodium/Indium heterobimetallic alloy as an effective catalyst for reductive C(sp3)─O silylation of ethers with chlorosilanes}, volume = {64}, year = {2025}, }
• (2025). Mechanistic insights into cation effects in electrolytes for electrocatalysis. ANGEW, 64(28), e202505022. (www)

  @article{ , abstract = {Traditional understanding of electrocatalytic reactions has primarily focused on the covalent interactions between adsorbates and catalyst surfaces, often overlooking the significant influence of the electrolyte on the catalytic process. Recently, researchers have highlighted the pivotal role of cations in the electrolyte, demonstrating their capability to modulate the reaction pathways and thus the activity and selectivity. These findings underscore the need for a deeper, atomic-level understanding of the electrode–electrolyte interface. This perspective presents the mechanisms through which cations affect electrocatalysis, with a focus on the hydrogen-bond network, the adsorption behavior of reaction intermediates, the electric field within the electrochemical double layer, and the local electronic properties of catalysts. It provides a summary of the influences of cations on various electrocatalytic reactions, including hydrogen oxidation reaction (HOR), hydrogen evolution reaction (HER), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), nitrogen reduction reaction (NRR), nitrate reduction reaction (NO 3 − RR), and carbon dioxide reduction reaction (CO 2 RR). At the end, future research directions are provided to maximize the potential of leveraging the cation effects in the design of more efficient electrolyte systems.}, archive = {J_ANGEW}, author = {Qian Wu and Zhichuan J. Xu}, doi = {10.1002/anie.202505022}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202505022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanistic insights into cation effects in electrolytes for electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Cytochrome p450 mediated cyclohexane ring formation in forazoline biosynthesis. ANGEW, 64(28), e202504925. (www)

  @article{ , abstract = {Forazoline A, produced by the marine actinomycete Actinomadura sp. WMMB-499, is a unique PK/NRP hybrid macrolactone with promising antifungal in vivo efficacy through a previously unreported mechanism. Although a PKS/NRPS gene cluster was identified as a candidate for forazoline production, the precise biosynthetic pathway and the functions of the tailoring enzymes remain unclear. In this work, the functions of three cytochrome P450 mono-oxygenases (FrazP1P2P3) were characterized. Notably, FrazP2 was found to mediate cyclohexane ring formation from an 1,3,6-triene precursor during forazoline A biosynthesis, as confirmed by genetic and biochemical analysis. To gain structural and mechanistic insight into the activity of FrazP2, the crystal structure of a FrazP2-substrate complex has been solved at 2.3 Å resolution. The molecular dynamics simulations and DFT calculations revealed an unprecedented enzyme-catalyzed oxidative cyclization reaction by FrazP2. These findings expand our understanding of the catalytic diversity of cytochrome P450s, contributing to the diversification of natural products and enabling the creation of unnatural derivatives with increased antifungal potency.}, archive = {J_ANGEW}, author = {Xinru Chen and Yujie Zhang and Shiqi Li and Weiting Liao and Weixin Tao and Zixin Deng and Tim S Bugni and Hao Su and Fan Zhang}, doi = {10.1002/anie.202504925}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504925}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cytochrome p450 mediated cyclohexane ring formation in forazoline biosynthesis}, volume = {64}, year = {2025}, }
• (2025). Revealing the nature of non-covalent interactions in ionic liquids by combined pulse EPR and 19F NMR spectroscopy. ANGEW, 64(28), e202504882. (www)

  @article{ , abstract = {Ionic liquids (ILs) are a unique class of compounds that have attracted interest for numerous and diverse applications, ranging from solvents for sustainable synthesis to sustainable electrolytes. Understanding their nanostructure and solute-solvent interactions is a prerequisite to harnessing the full potential of ILs. It has been proposed that ILs solvate non-polar solutes via their alkyl chains through the formation of nanoscale structures, such as micelles. Here, we determine the non-covalent interactions responsible for such nanostructuring in ILs. We use pulse electron paramagnetic resonance (EPR), paramagnetic relaxation enhancement (PRE) NMR, molecular dynamics (MD), and density functional theory (DFT) calculations in combination with ILs tailored to probe specific interactions through spin and isotopic labelling. Inter- and intramolecular cation–anion interactions are probed by electron-nuclear double resonance (ENDOR) and 19 F PRE experiments and show that nitroxide solutes associate with the polar domains of the imidazolium cation through weak hydrogen bonding with the imidazolium ring protons, as supported by MD simulations. Thus, this study reveals a less structured nanostructure than a micellar picture might suggest, but with clear IL cation-solute interactions. Our methodology to reveal nanostructure not only has implications for ILs but is also applicable to other soft matter systems.}, archive = {J_ANGEW}, author = {Ciarán J. Rogers and Spyridon Koutsoukos and Jana Eisermann and Luke Wylie and Gavin J. Smith and Tom Welton and Maxie M. Roessler}, doi = {10.1002/anie.202504882}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504882}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing the nature of non-covalent interactions in ionic liquids by combined pulse EPR and 19F NMR spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Chiral spirobipyridine synthesis by cobalt-catalyzed enantioselective double [2 + 2 + 2] cycloaddition. ANGEW, 64(28), e202504831. (www)

  @article{ , abstract = {Chiral spirobiindanes are recognized as the privileged structures in the field of asymmetric catalysis. However, the structurally similar chiral spirobipyridines have not yet been explored as chiral ligands or organocatalysts due to the absence of efficient synthetic methods. Herein, we report a cobalt-catalyzed enantioselective synthesis of spirobipyridines via double [2 + 2 + 2] cycloaddition reaction. Spirobipyridines with ortho- or meta-substituents could be obtained with exclusive regioselectivity and up to 99% ee in the presence of cobalt and bisoxazolinephosphine ligands. Spirobipyridines coordinate with transition metals as chiral ligands. Spirobipyridine dioxides can be applied as chiral organocatalysts in the asymmetric allylation of aldehydes.}, archive = {J_ANGEW}, author = {Ke Li and Danyang Zhu and Luyu Cao and Changkun Li}, doi = {10.1002/anie.202504831}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504831}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral spirobipyridine synthesis by cobalt-catalyzed enantioselective double [2 + 2 + 2] cycloaddition}, volume = {64}, year = {2025}, }
• (2025). Antiparallel β-sheet as a key motif of amyloid-β inhibitor designed via topological peptide reprogramming. ANGEW, 64(28), e202504640. (www)

  @article{ , abstract = {Peptide inhibitor design targeting self-assembly of amyloid- β (A β ) represents a promising strategy for suppressing the pathogenic mechanism of Alzheimer's disease (AD). Conventional approaches have primarily mimicked repetitive sequences found in fibrillar structures of A β aggregates. However, since the inherent flexibility of A β structures promotes the structural changes in the early-stage oligomerization, a structural modulation should be considered in the design of peptide inhibitors. Herein, we introduce topological reprogramming of peptides to control the structural transformation in pathogenic A β 1–42 (A β 42). The eleven-residue peptide scaffold P a11 ( 14 HQKLVNFAEDV 24 ) identified through the initial screening was dimerized via a disulfide bond. The dimerization stabilizes A β 42 into higher order structures by promoting antiparallel β -sheet conformations, thereby significantly suppressing A β 42 aggregation. Our approach underscores that modification in peptide connectivity would be a breakthrough for controlling the intrinsic flexibility of A β , surpassing the limitation in conventional, one-dimensional peptide building block.}, archive = {J_ANGEW}, author = {Dongjoon Im and Ye Eun Lee and Gyusub Yoon and William A. Goddard and Tae Su Choi and Hugh I. Kim}, doi = {10.1002/anie.202504640}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antiparallel β-sheet as a key motif of amyloid-β inhibitor designed via topological peptide reprogramming}, volume = {64}, year = {2025}, }
• (2025). Production of H2O2 via energy transfer photocatalysis by coupling with furfuryl alcohol conversion over an amide-functionalized heptazine framework. ANGEW, 64(28), e202504635. (www)

  @article{ , abstract = {Photocatalytic oxygen reduction provides a sustainable approach for hydrogen peroxide (H 2 O 2 ) synthesis, but the charge carrier-based pathway is severely limited by inefficient charge separation and redox decomposition of the produced H 2 O 2 . Energy transfer photocatalysis (EnTP) is an alternative charge-carrier-free route for H 2 O 2 synthesis. Herein, we propose a strategy of killing two birds with one stone to simultaneously realize the synthesis of H 2 O 2 and conversion of a biomass derivative by coupling EnTP with the Achmatowicz reaction. Results show efficient production of H 2 O 2 at a rate of 14.6 mmol g cat −1 h −1 and an apparent quantum yield (AQY) of 44.1% at 420 nm, coupled with the conversion of biomass-derived furfuryl alcohol (FFA) into hydroxy-2H-pyran-3(6H)-one with a high selectivity of 85.9%. Such a performance was attributed to the efficient EnTP over the amide-functionalized heptazine framework photocatalyst for singlet oxygen generation, which induces the FFA conversion and concurrently produces H 2 O 2 . A systematic study of the photoexcitation process of the catalysts reveals that the amide functionalization significantly improves the intersystem crossing (ISC) efficiency, as the structural modification optimizes the electronic structure and thus tunes the composition and distribution of energy bands.}, archive = {J_ANGEW}, author = {Liangpang Xu and Ka Shuen Yeung and Lejing Li and Xixian Nan and Oleksandr Savateev and Zhuofeng Hu and Jimmy C. Yu}, doi = {10.1002/anie.202504635}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504635}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Production of H2O2 via energy transfer photocatalysis by coupling with furfuryl alcohol conversion over an amide-functionalized heptazine framework}, volume = {64}, year = {2025}, }
• (2025). Phosphinoisocyanide/Alkyne cycloaddition: Generation of azaphospholylidene (NPHC) ligands. ANGEW, 64(28), e202504620. (www)

  @article{ , abstract = {Phosphinoisocyanide complexes undergo facile [3 + 2] cycloaddition reactions with activated alkynes to afford the first azaphospholylidene complexes which are rare examples of N,P -heterocyclic carbenes (NPHC). In addition to quantifying the donor/acceptor properties of this new class of carbene, their transmetalation reactions are also described.}, archive = {J_ANGEW}, author = {Ryan M. Kirk and Anthony F. Hill}, doi = {10.1002/anie.202504620}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504620}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phosphinoisocyanide/Alkyne cycloaddition: Generation of azaphospholylidene (NPHC) ligands}, volume = {64}, year = {2025}, }
• (2025). High-security and high-efficiency information Encryption/Decryption based on 2D hybrid Organic–Inorganic perovskites via delicate organic-cation engineering. ANGEW, 64(28), e202504327. (www)

  @article{ , abstract = {Optical encryption based on stimuli-responsive luminescence (SRL) materials has received enormous interest in the field of information security. Metal–halide perovskites, as a newly emerging SRL material, have shown great potential for confidential information encryption/decryption (InfoED) applications. However, it is rather challenging to ensure high security and achieve high readout efficiency in perovskite SRL-based InfoED. Herein, we present a unique InfoED strategy using 2D hybrid organic–inorganic perovskites via delicate organic-cation engineering, benefiting from the high contrast and quick response of their photoluminescence behaviors. Indistinguishably encrypted information can be efficiently decrypted through triple-key implementation (i.e., ultraviolet-light irradiation, temperature control, and narrow-bandpass filtering) that operates in multiple switching modes, enabling us to demonstrate extremely high security by adopting dot-matrix patterning scenarios that are virtually uncrackable. As a proof of principle, a simple 2 × 2 patterning can yield a code dictionary with random variants as high as ∼10 47 , which will take as long as ∼10 22 years to crack using the hitherto fastest supercomputer, El Capitan. Our perovskite SRL-based InfoED strategy provides a promising solution for information security based on optical encryption.}, archive = {J_ANGEW}, author = {Ziang Chen and Zhoushilin Ruan and Shenlong Jiang and Qun Zhang and Yi Luo}, doi = {10.1002/anie.202504327}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-security and high-efficiency information Encryption/Decryption based on 2D hybrid Organic–Inorganic perovskites via delicate organic-cation engineering}, volume = {64}, year = {2025}, }
• (2025). Multiple and alternative sites make tau protein an adaptable sticky surface for the SH3 domain of fyn kinase. ANGEW, 64(28), e202504292. (www)

  @article{ , abstract = {The interaction between the microtubule associated protein Tau and the tyrosine kinase Fyn is believed to play a pivotal role in the early stage of Alzheimer's disease. Previous studies have identified the SRC Homology 3 (SH3) domain of Fyn as the binding receptor of several proline-rich motifs in Tau. However, the role of each proline-rich motif and their interplay in molecular recognition are still unclear. In this work, we investigated the mechanism of Fyn-SH3 recognition by the multiple PxxP sites inserted within the full-length Tau protein by using nuclear magnetic resonance (NMR) spectroscopy combined with computational, calorimetric and in-cell FRET (Förster resonance energy transfer) methods. Both in vitro and in-cell experiments revealed no single binding site strictly necessary for the binding. Instead, Fyn-SH3 contacts full-length Tau on multiple hot spot regions, located over a distance of 85 residues, through global moderate-to-low affinity interactions. Beyond two principal regions containing classical PxxP motifs, we identified a novel non-canonical binding site at the beginning of the microtubule binding domain. Our study indicates that multiple binding sites in Tau are involved in the interaction, making Tau an adaptable recognition surface that can function when single consensus motifs are deleted.}, archive = {J_ANGEW}, author = {Roberto Tira and Giulia Leo and Laura Prandini and Carlo Giorgio Barracchia and Mariapina D'Onofrio and Luca Mollica and Stefano Capaldi and Michael Assfalg and Francesca Munari}, doi = {10.1002/anie.202504292}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504292}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple and alternative sites make tau protein an adaptable sticky surface for the SH3 domain of fyn kinase}, volume = {64}, year = {2025}, }
• (2025). Data-driven review on aerogels and polymeric aerogels. ANGEW, 64(28), e202504250. (www)

  @article{ , abstract = {A thoroughly data-driven review on the chemistry, properties, and applications of aerogels is provided. Aerogel is a category of solid materials having homogeneous, highly porous nanostructures. Unique physicochemical properties of aerogels have attracted much attention in wide fields due to their potentials for energy/environmental issues in the 21st century, while an exponentially increasing number of papers are causing an academic fever and unreliable data issues. Statistical analysis based on an exhaustive literature survey from almost all the papers with “aerogel” in their titles reveals a flood of freeze-dried aerogels mainly consisting of organic polymers and organic–inorganic composites. Process-property data from polymer aerogel papers are analyzed by a machine-learning approach aiming to establish data infrastructure toward future aerogel studies. Data-evidenced critical discussion specifies a tendency in unreliable thermal conductivity data of these papers.}, archive = {J_ANGEW}, author = {Satoru Takeshita and Shinya Mine and Takumi Ono}, doi = {10.1002/anie.202504250}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504250}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Data-driven review on aerogels and polymeric aerogels}, volume = {64}, year = {2025}, }
• (2025). Programming one-dimensional open-channel superlattices with edge-bonding of meta-DNA. ANGEW, 64(28), e202504223. (www)

  @article{ , abstract = {The physicochemical properties of one-dimensional (1D) porous nanomaterials are fundamentally influenced by their channel geometrical and topological characteristics. However, synthesis of geometrically and topologically diversified 1D porous crystals spanning the mesoporous-to-macroporous range remains a significant challenge. Here, we present a universal strategy for constructing 1D open-channel superlattices through edge-to-edge assembly (edge-bonding) of DNA-sparsely modified meta-DNA (M-DNA). By programming the rigidity and length of sparsely distributed DNA bonds on M-DNA surfaces, we achieved long-range ordered assembly of triangular M-DNA 1D single-channel superlattice (3.7 ± 1.2 µm) with a macroporous structure. The generality of this approach was further demonstrated by assembling hexagonal M-DNA into 1D multi-channel superlattice (3.6 ± 1.0 µm) with a mesoporous structure, thereby reducing the pore size from 140 to 29 nm and the porosity from ∼94.2 to ∼87.5%. Furthermore, an ultrathin gold layer grown on the triangular M-DNA superlattice exhibited a ∼3.3-fold enhancement in electrocatalytic activity compared to non-assembled triangular M-DNA, attributed to the increased surface area and narrower bandgap. This work broadens the design framework for porous crystals assembled via DNA nanotechnology and highlights their potential applications in catalysis, energy conversion, and beyond.}, archive = {J_ANGEW}, author = {Qin Xu and Le Li and Xiaoliang Chen and Changmao Huang and Jiangbo Liu and Wenhe Ma and Meiyuan Qi and Xiaolei Zuo and Xiaoguo Liu and Mingqiang Li and Xiangyuan Ouyang and Chunhai Fan and Guangbao Yao}, doi = {10.1002/anie.202504223}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programming one-dimensional open-channel superlattices with edge-bonding of meta-DNA}, volume = {64}, year = {2025}, }
• (2025). Phenacetin[3]Arenes: Mannich-type macrocyclization, unique structure, versatile functionalization, and strong allosteric binding. ANGEW, 64(28), e202504211. (www)

  @article{ , abstract = {This work introduces a novel N Am –CH₂–C Ar macrocyclization pathway, diverging from the conventional C Ar –CH₂–C Ar linkages prevalent in macrocyclic arenes. This approach involves a one-pot condensation of - Phenacetin and its homologs with formaldehyde, yielding phenacetin[3]arenes ( Ph[3] s) in yields up to 25.9%. Ph[3] exhibits an unsymmetrical hourglass-shaped architecture, featuring an upper rim adorned with amide groups and a lower rim comprising an alkoxylbenzene cavity. This unique structure facilitates reversible equilibrium between conformers via benzene ring flipping, which simultaneously reverses the orientation of amide groups, establishing equilibrium between C 3 and F conformers. Increasing concentrations of organic ammonium guests lead to a transition from a predominantly 1:1 to 1:2 host–guest complexation. The estimated binding constants for the 1:1 complexes are in the order of 10 4 –10 5 M −1 , the overall binding constants for the 1:2 complexes are greater than 10 6 M −2 . This stepwise complexation triggers a conformational shift from the C 3 to F conformer, demonstrating intriguing allosteric behavior. Furthermore, interactions with chiral guests selectively influence the equilibrium of planar chiral conformers, generating chiroptical responses suitable for chirality sensing applications. The distinct functional groups on the two rims facilitate diverse chemical modifications, including reduction, deprotection, and condensation, providing synthetic flexibility for post-chemical modifications.}, archive = {J_ANGEW}, author = {Yanling Shen and Xiaotong Liang and Tianning Ma and Dayang Zhou and Wenjia Liu and Jingyu Ma and Wanhua Wu and Zhipeng Yu and Cheng Yang}, doi = {10.1002/anie.202504211}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504211}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phenacetin[3]Arenes: Mannich-type macrocyclization, unique structure, versatile functionalization, and strong allosteric binding}, volume = {64}, year = {2025}, }
• (2025). Hierarchically self-assembled anion-coordination-driven gels for guest segregation and electrical sensing. ANGEW, 64(28), e202504207. (www)

  @article{ , abstract = {The search for macroscopic materials with differentially addressable spaces based on molecular containers has long been driven by their great potential for diverse practical applications pertaining guest selective capture and release. Herein, we report a class of gels ( G 1-NH2 , G 1-UPy , G 2-NH2 , and G 2-UPy ) that are formed through hierarchical self-assembly of anion-coordinated architectures. The well-defined shapes and sizes of the cavities within anion-coordinated architectures endow the gels with different internal phases, which is beneficial to differentiate the release profiles of guest molecules (dimethylethanolamine, choline, and propyl trimethylammonium) depending on their binding affinity. This study also introduces the concept of flowing a solution containing guests through a host-containing gel for effective guest separation. The process of guest binding could be also monitored in real time via electrical characterization. This work may thus provide a useful strategy for selective solid-phase molecular separation.}, archive = {J_ANGEW}, author = {Jie Zhao and Yidan Li and Huidan Zhang and Ruying Lv and Le Yu and Silvia Marchesan and Dong Yang}, doi = {10.1002/anie.202504207}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504207}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hierarchically self-assembled anion-coordination-driven gels for guest segregation and electrical sensing}, volume = {64}, year = {2025}, }
• (2025). Site-specific spin state modulation in spinel oxides for enhanced nonradical oxidation. ANGEW, 64(28), e202504189. (www)

  @article{ , abstract = {Spinel oxides hold tremendous potential for driving advanced oxidation processes, yet the underlying mechanism for maximizing their activity remains unclear. In this study, we leverage tetrahedral and octahedral site interactions in Mn x Co 3-x O 4 to modulate the spin states, specifically spin alignment and spin moment, thereby enhancing periodate (PI) activation and catalytic performance in contaminant degradation. Through combined experimental and density functional theory (DFT) analyses, we elucidate the role of spin alignment at synergetic tetrahedral and octahedral sites in facilitating quantum spin exchange interactions (QSEI) with an efficient electronic spin channel for charge transfer. Meanwhile, the engineered high spin configuration in CoMn 2 O 4 raises the d -band center, favoring stable PI* surface complex formation and accelerating the rate-determining desorption of IO 3 − with a lower-ICOHP value during the catalytic degradation of ciprofloxacin. As a result, the fine-tuned spin state of CoMn 2 O 4 leads to enhanced overall reaction kinetics, with a 2.5-fold increase compared to MnCo 2 O 4 and up to 22-fold increase compared to the octahedrally-active only catalysts. Such a site-specific modulation has been found applicable to other spinel oxides, enlightening fine-tuned electronic structure for maximizing catalytic performance.}, archive = {J_ANGEW}, author = {Jingdan Shi and Yaxin Cheng and Ting Wang and Yanhua Peng and Xinlong Lin and Bing Tang and Mingbao Feng and Zechao Zhuang and Yuanmiao Sun and Xin Yu and Zhichuan J. Xu}, doi = {10.1002/anie.202504189}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202504189}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-specific spin state modulation in spinel oxides for enhanced nonradical oxidation}, volume = {64}, year = {2025}, }
• (2025). Nanoparticle-mediated targeted protein degradation: An emerging therapeutics technology. ANGEW, 64(28), e202503958. (www)

  @article{ , abstract = {Targeted protein degradation (TPD) has emerged as a transformative therapeutic strategy for eliminating disease-associated proteins, with relevance across disorders ranging from cancer to neurodegeneration. Since its inception nearly two decades ago, TPD has attracted strong academic and commercial interest, with multiple candidates advancing into clinical trials. Despite this progress, the field faces persistent challenges, including limited solubility, poor cellular uptake, and unpredictable structure–activity relationship of small-molecule degraders, which complicate rational design. To address these limitations, alternative platforms such as nanoparticle-mediated protein degraders (NanoPDs) have gained attention. First reported 17 years ago, NanoPDs harness a diverse array of materials, degradation mechanisms, and linker chemistries to achieve protein clearance through novel pathways. Although promising, their clinical translation remains constrained by barriers such as lysosomal entrapment, protein corona formation, and biocompatibility concerns. In this review, we present a comprehensive overview of the current landscape of nanoparticle-mediated TPD. We emphasize the design principles underlying nano–bio interfaces and explore the role of proximity-induced biology as a mechanism for orchestrating protein interactions. Finally, we highlight critical challenges and key questions that must be addressed to fully realize the therapeutic potential of NanoPDs.}, archive = {J_ANGEW}, author = {Andrew G. Baker and Adrian Pui Ting Ho and Laura S. Itzhaki and Ljiljana Fruk}, doi = {10.1002/anie.202503958}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503958}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanoparticle-mediated targeted protein degradation: An emerging therapeutics technology}, volume = {64}, year = {2025}, }
• (2025). High-performance Cu6Sn5 alloy electrocatalysts for formaldehyde oxidative dehydrogenation and bipolar hydrogen production. ANGEW, 64(28), e202503828. (www)

  @article{ , abstract = {Aldehyde-assisted water electrolysis offers an attractive pathway for energy-saving bipolar hydrogen production with combined faradaic efficiency (FE) of 200% while converting formaldehyde into value-added formate. Herein we report the design and synthesis of noble metal-free Cu 6 Sn 5 alloy as a highly effective electrocatalyst for formaldehyde electro-oxidative dehydrogenation, demonstrating a geometric current density of 915 ± 46 mA cm −2 at 0.4 V versus reversible hydrogen electrode, outperforming many noble metal electrocatalysts reported previously. The formaldehyde-assisted water electrolyzer delivers 100 mA cm −2 at a low cell voltage of 0.124 V, and a current density of 486 ± 20 mA cm −2 at a cell voltage of 0.6 V without any iR compensation and exhibits nearly 200% faradaic efficiency for bipolar hydrogen production at 100 mA cm −2 in 88 h long-term operation. Density functional theory calculations further confirm the notably lowered barriers for dehydrogenation and Tafel steps on the Cu₆Sn₅ surface compared to Cu, underscoring its potential as a highly active catalyst.}, archive = {J_ANGEW}, author = {Xiaoyang Fu and Dongfang Cheng and Ao Zhang and Jingxuan Zhou and Sibo Wang and Chengzhang Wan and Xun Zhao and Jun Chen and Philippe Sautet and Yu Huang and Xiangfeng Duan}, doi = {10.1002/anie.202503828}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503828}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance Cu6Sn5 alloy electrocatalysts for formaldehyde oxidative dehydrogenation and bipolar hydrogen production}, volume = {64}, year = {2025}, }
• (2025). Tuning local proton concentration and *OOH intermediate generation for efficient acidic H2O2 electrosynthesis at ampere-level current density. ANGEW, 64(28), e202503626. (www)

  @article{ , abstract = {Electrocatalytic oxygen reduction is a sustainable method for on-site H 2 O 2 synthesis. The H 2 O 2 in acidic media has wide downstream applications, but acidic H 2 O 2 electrosynthesis suffers from poor efficiency due to high proton concentration and unfavourable *OOH (key intermediate) generation. Herein, acidic H 2 O 2 electrosynthesis was enhanced by regulating local proton availability and *OOH generation via fluorine-doped on inner and outer walls of carbon nanotubes (F-CNTs). It was efficient and stable for H 2 O 2 electrosynthesis with Faradaic efficiency of 95.6% and H 2 O 2 yield of 606.6 mg cm −2 h −1 at 1.0 A cm −2 and 0.05 M H 2 SO 4 , outperforming the state-of-the-art electrocatalysts. The F-doping regulated the electronic structure of CNTs with elevated p-band center, and F-doping on its inner and outer walls also enhanced nanoconfinement effect and superhydrophobicity, respectively. As a result, a local alkaline microenvironment was created on F-CNTs surface during acidic H 2 O 2 electrosynthesis. The energy barrier for *OOH generation was significantly reduced and oxygen mass transfer was boosted. Their synergistic effects promoted acidic H 2 O 2 electrosynthesis. This work provides new insights into the mechanism for regulating H 2 O 2 electrosynthesis.}, archive = {J_ANGEW}, author = {Genwang Zhu and Shuaijie Zhao and Yueling Yu and Xinfei Fan and Kaiyuan Liu and Xie Quan and Yanming Liu}, doi = {10.1002/anie.202503626}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning local proton concentration and *OOH intermediate generation for efficient acidic H2O2 electrosynthesis at ampere-level current density}, volume = {64}, year = {2025}, }
• (2025). Polyphosphorus ligand complexes of coinage metals for multiple capturing of intact p4 tetrahedra. ANGEW, 64(28), e202503614. (www)

  @article{ , abstract = {Two- and three-component self-assembly reactions of [Cp R Fe(η 5 -P 5 )] (Cp R = C 5 (CH 3 ) 5 (Cp*, 1a ), C 5 (4-EtC 6 H 4 ) 5 ) (Cp PEt , 1b )) with the coinage metal salts [Cu(CH 3 CN) 4 ][SbF 6 ] or AgSbF 6 were investigated to study the prerequisites for the potential coordination of white phosphorus by using a sterically encumbered Cp R ligand and noncoordinating anions. In the self-assembly reactions with white phosphorus, either 0D or 1D coordination complexes are formed, all of which feature coordinated intact P 4 tetrahedra and thus comprise an unprecedented class of mixed polyphosphorus ligand complexes capable of complete release of P 4 in solution confirmed by NMR studies. The bulkiness of the used Cp R ligand and the correctly chosen solvent allowed for obtaining more beneficial structural motifs, the first discrete tetra- and penta-coordinated cyclo -P 5 ligand complexes, that provide the maximal content of coordinated P 4 molecules per species known so far. All products are characterized by single-crystal X-ray diffraction, NMR spectroscopy, and mass spectrometry.}, archive = {J_ANGEW}, author = {Claudia Göschl and Eugenia Peresypkina and Barbara Hiltl and Alexander V. Virovets and Gabor Balázs and Manfred Scheer}, doi = {10.1002/anie.202503614}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503614}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyphosphorus ligand complexes of coinage metals for multiple capturing of intact p4 tetrahedra}, volume = {64}, year = {2025}, }
• (2025). High-entropy sulfides catalyze rate-determining redox in fast-charging aqueous Zinc–Sulfur batteries. ANGEW, 64(28), e202503472. (www)

  @article{ , abstract = {The sluggish kinetics of the solid–solid Zn–S redox process significantly hinders the practical energy density and lifespan of fast-charging aqueous Zn–S batteries (AZSBs). Conventional low-entropy catalysts suffer from poor stability, leading to leaching effects and water splitting during cycling. To overcome these limitations, we present a three-step synthesis of high-entropy sulfide (HES) nanorod catalysts to accelerate the rate-determining step (RDS) in the Zn–S redox process. Operando synchrotron powder diffraction, operando synchrotron infrared reflectance microscopy, and operando Raman spectroscopy characterizations reveal that the HES catalysts improve sulfur utilization by accelerating the RDS conversion of ZnS 2 to wurtzite ZnS. Furthermore, near-edge X-ray absorption fine structure and inductively coupled plasma mass spectrometry analyses demonstrate that the HES catalysts effectively suppress the leaching effect of transition metals and water splitting of the aqueous electrolyte, improving cycling stability. In contrast, utilizing medium- and low-entropy catalysts results in the formation of by-products, including S 5 2− , S 3 2− , and SO 3 2− species. Consequently, the pouch cell with the HES catalysts delivers a high cathode energy density of 313 Wh kg −1 and high cycling stability over 400 cycles at 4 C with 0.06% capacity decay per cycle. This entropy-driven catalytic strategy provides an effective approach for developing stable and fast-charging aqueous metal–sulfur batteries.}, archive = {J_ANGEW}, author = {Jiahao Liu and Han Wu and Chao Ye and Shi-Zhang Qiao}, doi = {10.1002/anie.202503472}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy sulfides catalyze rate-determining redox in fast-charging aqueous Zinc–Sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Cost-effective and low-carbon scalable recycling of waste polyethylene terephthalate through bio-based guaiacol-enhanced methanolysis. ANGEW, 64(28), e202503469. (www)

  @article{ , abstract = {The global plastic waste crisis, particularly from polyethylene terephthalate (PET), demands sustainable recycling solutions. PET methanolysis offers a promising route to recover high-purity dimethyl terephthalate (DMT), but achieving scalable, cost-effective, and environmentally friendly processes under mild conditions remains challenging. This study introduces a bio-based catalytic system using guaiacol and potassium bicarbonate (KHCO 3 ) under mild conditions (120 °C, 0.6 MPa), achieving 94% DMT and 98% ethylene glycol (EG) yields within 2 h. Unlike conventional acid-catalyzed or co-solvent-assisted methanolysis methods, the phenolic hydroxyl group of guaiacol critically stabilizes the tetrahedral intermediate, significantly enhancing catalytic efficiency. The system demonstrates broad versatility across various polyesters and real-world PET waste streams, including mixed textiles and colored plastics, while enabling selective depolymerization. Life cycle assessment (LCA) and techno-economic analysis (TEA) confirm its low carbon footprint, energy efficiency, and industrial viability. This cost-effective and scalable strategy offers a sustainable solution for PET recycling, addressing both environmental and economic challenges while advancing resource circularity in the plastic industry.}, archive = {J_ANGEW}, author = {Yunkai Yu and Yufei Zhang and Siming Zhu and Qingqing Mei}, doi = {10.1002/anie.202503469}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503469}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cost-effective and low-carbon scalable recycling of waste polyethylene terephthalate through bio-based guaiacol-enhanced methanolysis}, volume = {64}, year = {2025}, }
• (2025). Manipulation of hydrogen transfer behaviors by RhCu alloying enables an all-in-one sustainable “Furfural-nitrate” system. ANGEW, 64(28), e202503424. (www)

  @article{ , abstract = {Nitrate and furfural are typical wastes mainly from industrialization and agriculturalization progresses, and their clean conversions are still very challenging for a sustainable future. Nevertheless, scant attention has been devoted to the core issues: the rational integration of two wastes recycling and the targeted manipulation of hydrogen (H*) transfer behaviors to address their sluggish reaction kinetics. Herein, we report an all-in-one electrochemical energy system that is thermodynamically designed by coupling nitrate reduction (NO 3 RR) and furfural oxidation reactions (FORs) together. Particularly, the poor kinetics for both electrode reactions are efficaciously optimized by the bifunctional electrocatalyst of RhCu alloy nanowires on copper foam (RhCu NW/CF) with highly improved dual-directional H*-modulation performances, thus initializing NO 3 RR for NH 3 synthesis at +0.31 V and driving FOR for H 2 harvest at an onset potential lower than 0 V. Eventually, such integrated “Furfural-Nitrate” system can simultaneously effectuate the electricity energy supply (10.76 mW cm −2 ), wastewater purification, cathodic hydrogen storage (NH 3 ), anodic H 2 production, and biomass upgrading. Hence, it provides a promising perspective of “turning waste into treasure” in a rational manner, justifying its all-in-one property in addressing the global challenge of sustainable energy.}, archive = {J_ANGEW}, author = {Xin Long and Bin Zhao and Danni Liu and Guodong Fu and Hang Yang and Renfei Feng and Ning Chen and Hekun Ding and Jiayi Wu and Yuanfeng Liao and Shaoqing Liu and Yu Zhang and Xian-Zhu Fu and Jing-Li Luo}, doi = {10.1002/anie.202503424}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulation of hydrogen transfer behaviors by RhCu alloying enables an all-in-one sustainable “Furfural-nitrate” system}, volume = {64}, year = {2025}, }
• (2025). Whole-cell lysosome SMLM imaging as indicators for functional diagnostics with a low-phototoxic spontaneously blinking probe. ANGEW, 64(28), e202503177. (www)

  @article{ , abstract = {Lysosomal morphology and pH dynamics are key indicators of lysosomal function, making long-term single-molecule localization microscopy (SMLM) imaging a promising tool for functional diagnostics. However, phototoxicity often compromises imaging reliability. Here, we develop Aze-HMSiR , a spontaneously blinking silicon rhodamine probe with near-infrared excitation, enabling low-phototoxicity, long-term (50 min) SMLM imaging of lysosomal morphology and pH dynamics. This probe provides super-resolution insights into lysosomal distribution, size, and lumen pH, essential for understanding their physiological and pathological roles. Using Aze-HMSiR , we investigate lysosomal function under acidosis, starvation, and anticancer drug treatments. Among seven tested drugs, periplocoside significantly reduced lysosomal size, while paclitaxel increased pH and altered lysosomal distribution. These findings highlight Aze-HMSiR as a powerful tool for lysosomal functional diagnostics and drug screening, offering a robust platform for studying lysosomal dynamics in response to physiological and pharmacological perturbations, particularly in cancer therapy.}, archive = {J_ANGEW}, author = {Qinglong Qiao and Aoxuan Song and Guanyu Jiang and Yuxin Zhou and Yiyan Ruan and Wenhao Jia and Xiaogang Liu and Zhaochao Xu}, doi = {10.1002/anie.202503177}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503177}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Whole-cell lysosome SMLM imaging as indicators for functional diagnostics with a low-phototoxic spontaneously blinking probe}, volume = {64}, year = {2025}, }
• (2025). Dihydrophenazine derived Pd6L12 cage: Self-assembly, polyradical cations, and lithium battery cathode application. ANGEW, 64(28), e202503151. (www)

  @article{ , abstract = {In this study, we present the self-assembly of a dihydrophenazine-based Pd 6 L 12 -type coordination cage 1 showing excellent redox activity and demonstrate the use as the cathode for lithium batteries. The structure of cage 1 was confirmed by single-crystal X-ray diffraction analysis. The excellent reversible redox performance of 1 and its electrochromic properties induced by radical species were systematically characterized using in situ UV–vis–NIR and EPR spectroelectrochemistry. Notably, a highly stable radical cationic species 1 12•+ , containing 12 radical cations, was successfully obtained through the chemical oxidation of 1 , and its single-crystal structure was resolved. The excellent redox properties of 1 enable its application as a cathode material for lithium batteries. The 1 |Li cell exhibited good cycling stability, nearly 100% coulombic efficiency, and an initial discharge capacity of 84 mAh g⁻¹ within a voltage range of 2.5–4.0 V. Furthermore, in situ 2D EPR experiments on lithium batteries visually revealed the excellent cycling stability of the 1 -based cathode material and its reversible two-step electron transfer process. This study provides important insights into the design, synthesis, and properties of functionalized redox-active coordination cages, offering a reference for their application in energy storage and functional materials research.}, archive = {J_ANGEW}, author = {Meng-Xiang Wu and Yingli Li and Jiefan Liu and Bin Huang and Qiong-Yan Hong and Wei-Ling Jiang and Yu Zhao and Gaole Dai and Bingwen Hu and Xueliang Shi and Hai-Bo Yang}, doi = {10.1002/anie.202503151}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dihydrophenazine derived Pd6L12 cage: Self-assembly, polyradical cations, and lithium battery cathode application}, volume = {64}, year = {2025}, }
• (2025). Modular access to arylethylamines enabled by ni-catalyzed markovnikov-selective hydroarylation of allylic amines. ANGEW, 64(28), e202503126. (www)

  @article{ , abstract = {Arylethylamines are prevalent structural skeletons in bioactive molecules and have significant interest within the organic chemistry community. We report here a modular and efficient nickel-catalyzed Markovnikov -selective hydroarylation of readily available allylic amines, delivering a wide variety of valuable arylethylamines with complete regiocontrol under mild conditions. Key to the success of this protocol is the employment of bulky N -heterocyclic carbenes (NHCs) as ligands. Furthermore, the use of chiral NHC ligands enables straightforward access to enantioenriched arylethylamines with excellent regio- and enantioselectivities.}, archive = {J_ANGEW}, author = {Hai-Yu Wu and Ming Joo Koh and Zi-Chao Wang and Shi-Liang Shi}, doi = {10.1002/anie.202503126}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503126}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular access to arylethylamines enabled by ni-catalyzed markovnikov-selective hydroarylation of allylic amines}, volume = {64}, year = {2025}, }
• (2025). Turing-structured covalent organic framework membranes for fast and precise peptide separations. ANGEW, 64(28), e202503090. (www)

  @article{ , abstract = {Turing structures have emerged as promising features for separation membranes, enabling significantly enhanced water permeation due to their ultra-permeable internal cavities. So far, Turing structures are constrained by the highly cross-linked and heterogeneous porosities, impeding them from the application of molecular separations requiring loose but regular pore structures. This work reports a covalent organic frameworks (COFs) membrane with nanoscale striped Turing structures for fast and precise molecular separations. Porous and hydrophilic modulation layers based on metal-polyphenol chemistry are constructed on polymeric substrates, which are capable of enhancing the uptake and controlled release of the activator of amines during synthesis. The appropriately reduced diffusion rate triggers the phenomenon of “local activation and lateral inhibition” arising from thermodynamic instability, creating Turing structures with externally striped and internally cavitated architectures. The Turing-type COF membranes exhibit a water permeance of 45.0 L m −2 h −1 bar −1 , which is approximately 13 times greater than the non-Turing membranes, and an ultrahigh selectivity of up to 638 for two model peptides. This work demonstrates the feasibility that Turing structures with ultra-permeable internal cavities can be created in COF membranes and underscores their superiority in molecular separations, including but not limited to high-value pharmaceuticals.}, archive = {J_ANGEW}, author = {Bingjie Gao and Youxin Gong and Zhe Zhang and Qinghua Liu and Congcong Yin and Mingjie Wei and Yong Wang}, doi = {10.1002/anie.202503090}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202503090}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Turing-structured covalent organic framework membranes for fast and precise peptide separations}, volume = {64}, year = {2025}, }
• (2025). Dynamic exchange reactions as self-blowing agents for the production of reprocessable foams. ANGEW, 64(28), e202502970. (www)

  @article{ , abstract = {Thermosetting foams are crucial in the polymer industry due to their unique lightweight and durable properties. Recent developments in sustainable chemistry intend to align foam lifecycles toward circular economy principles and reduce their environmental impact. In this study, this issue is addressed thanks to an innovative and straightforward approach, enabling the manufacture of single-component self-blowing vitrimer foam. The self-blowing mechanism originates from the in situ formation and release of the blowing agent via the polycondensation of an alkylester. This alkylester, composed of a benzoxazine matrix terminated with a β -hydroxylamine, undergoes in a cascade mechanism ring opening polymerization (ROP) and irreversible transesterification exchange, which in turn generates an alcohol gas. The cascade polymerization and alcohol release were optimized and fine-tuned to develop various foams that have an open-cell morphology, volume expansion of 223%–853%, porosity of 67%–86%, and compression modulus in the range of 3–38 MPa. The polymerization process results in a dual crosslinked poly(benzoxazine- co -ester) network composed of β -hydroxylamine moieties, alkyl, and β -aminoester bonds, enabling reversible transesterification dynamic exchanges and mechanical reprocessability, achieving a foam-to-resin reprocessing.}, archive = {J_ANGEW}, author = {Antoine Adjaoud and Anaë Girault-Fodil and Farida Baraka and Vincent Boulic and Benoit Marcolini and Laura Puchot and Pierre Verge}, doi = {10.1002/anie.202502970}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202502970}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic exchange reactions as self-blowing agents for the production of reprocessable foams}, volume = {64}, year = {2025}, }
• (2025). Light-triggered CRISPR/Cas12a for genomic editing and tumor regression. ANGEW, 64(28), e202502892. (www)

  @article{ , abstract = {A photo-triggered CRISPR/Cas12a machinery for in vitro and in vivo gene editing is introduced. The system consists of a caged, inactive ortho -nitrobenzyl phosphate ester photo-responsive crRNA, which, upon light-induced deprotection, yields the active CRISPR/Cas12a gene editing machinery (LAC12aGE). The LAC12aGE system induces specific thymidine-rich (TTTN) protospacer-adjacent motif (PAM)-guided double-stranded breaks in genomic DNA, which upon non-homologous end-joining lead to gene repair. The LAC12aGE machinery is applied for gene editing of an exogenous dual fluorescent reporter gene in living cells, as well as the endogenous gene encoding DNA methyltransferase 1. In addition, the LAC12aGE is applied for in vitro gene editing and disruption of the hepatocyte growth factor ( HGF ) gene in HepG2 cells, where knockout of the HGF gene results in inhibited cell proliferation and migration, as well as enhanced apoptosis. Moreover, the in vivo knockout and disruption of the HGF gene in HepG2 tumors by the LAC12aGE machinery is demonstrated. The cyclic temporal development of the LAC12aGE system in tumors shows effective inhibition of tumor growth and enhanced apoptosis/necrosis of tumor tissues compared to control systems.}, archive = {J_ANGEW}, author = {Hong Liu and Jiantong Dong and Renzhi Wu and Jun Dai and Xiaoding Lou and Fan Xia and Itamar Willner and Fujian Huang}, doi = {10.1002/anie.202502892}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202502892}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-triggered CRISPR/Cas12a for genomic editing and tumor regression}, volume = {64}, year = {2025}, }
• (2025). Induced chirality and vibrational optical activity in an ionic-liquid anion. ANGEW, 64(28), e202502885. (www)

  @article{ , abstract = {Here, we show that the four conformers of the regularly used ionic liquid anion bis(trifluoromethylsulfonyl)imide are true enantiomeric pairs by analyzing their calculated vibrational circular dichroism spectra. The significant modes involve those atoms of the anion that form specific hydrogen bond patterns with the chiral probe molecule propylene oxide. Adding this probe molecule to the ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, the experimental and simulated spectra indicate intermolecular interaction between the chiral molecule and the liquid and thus the induction of chirality in the anion. This emergence of chirality in the ionic liquid takes place via the hydrogen bonding between the anion of the ionic liquid and the solute, which results in a redistribution of the symmetric occurrence of conformers to an asymmetric one. Altogether, this study reveals the mechanism of chiral induction from the propylene oxide molecule to the ionic liquid anion, while pointing out the importance of rational over a random choice of the ionic liquid building units.}, archive = {J_ANGEW}, author = {Tom Frömbgen and Katrin Drysch and Thierry Tassaing and Thierry Buffeteau and Oldamur Hollóczki and Barbara Kirchner}, doi = {10.1002/anie.202502885}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202502885}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Induced chirality and vibrational optical activity in an ionic-liquid anion}, volume = {64}, year = {2025}, }
• (2025). Energy-efficient hydrogen generation via peroxide-mediated electrocatalytic pathways. ANGEW, 64(28), e202502735. (www)

  @article{ , abstract = {Hydrogen (H 2 ) production through water electrolysis is a promising route for sustainable energy storage. However, conventional water electrolysis faces several challenges, such as large thermodynamic potential gaps and sluggish oxygen evolution kinetics, which lead to high electricity consumption and limitations in H 2 storage and transportation. A promising approach to overcoming these hurdles is hybrid water electrolysis, which integrates alternative, thermodynamically favorable reactions at the anode to enhance efficiency. In this study, we explore how peroxide redox electrocatalysis can address critical barriers in sustainable H 2 production, storage, and transport. By leveraging a cost-effective and highly efficient peroxide redox electrocatalyst, we demonstrate various electrolysis configurations that significantly reduce the required cell voltage—from the standard 1.23 V down to −0.06 V, highlighting its potential for scalable and economically viable electrolysis methodologies for H 2 production.}, archive = {J_ANGEW}, author = {Alagar Raja Kottaichamy and Thamaraichelvan Marichelvam and Jonathan Tzadikov and Roni Cohen Vaza and Michael Volokh and Shmuel Barzilai and Menny Shalom}, doi = {10.1002/anie.202502735}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202502735}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Energy-efficient hydrogen generation via peroxide-mediated electrocatalytic pathways}, volume = {64}, year = {2025}, }
• (2025). Comparative study of solvatomorphs of stryker's reagent using MicroED and quantum mechanics. ANGEW, 64(28), e202502524. (www)

  @article{ , abstract = {The atomic position of hydrogen atoms in metal hydrides has been a long-standing structural question in inorganic chemistry given that hydride delivery is integral to diverse chemical reactions. Microcrystal electron diffraction (microED), with it's increased sensitivity toward hydrogen atoms relative to X-ray diffraction, offers a potential path to addressing this challenge. Herein, the first microED study of Stryker's reagent is reported, resulting in the structure of a new benzene solvate. Improved accuracy for hydrogen atom positions was obtained via a quantum crystallography (QCr) approach, Hirshfeld atom refinement (HAR). Structural and topological analysis supports edge bridging hydrides in the microED structure of a THF solvate form, consistent with previous diffraction studies. Interestingly, analysis of a new benzene solvate, discovered in this study, is consistent with mixed edge- and face-bridging hydrides.}, archive = {J_ANGEW}, author = {Kunal K. Jha and Jacob O. Rothbaum and Vignesh C. Bhethanabotla and Charles B. Musgrave and Christopher G. Jones and Sergey I. Morozov and William A. Goddard and Hosea M. Nelson}, doi = {10.1002/anie.202502524}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202502524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Comparative study of solvatomorphs of stryker's reagent using MicroED and quantum mechanics}, volume = {64}, year = {2025}, }
• (2025). Unveiling zinc stripping and molecular engineering for high-performance zinc anode. ANGEW, 64(28), e202501960. (www)

  @article{ , abstract = {The unstable zinc anode is a key challenge limiting the cycle life of rechargeable zinc-ion batteries. The current research primarily focuses on the zinc plating process, with strategies to induce uniform zinc deposition for a stable zinc anode. Here, we demonstrate that the zinc stripping process has a more significant impact on the subsequent zinc deposition, which exacerbates the formation of by-products, dendrites, and “dead zinc.” Therefore, we propose using aspartyl-phenylalanine methyl ester (APM) molecules to regulate the zinc stripping, achieving uniform stripping of the zinc anode by increasing the stripping overpotential across high-energy barriers. Simultaneously, its localized hydrophobic functional groups effectively inhibit the byproducts triggered by solvated water molecules. The experimental results show that the Zn-APM symmetric cell exhibits excellent cycling stability, with stable cycling over 6500 h (>9 months) at 1 mA cm −2 for 1 mAh cm −2 and 700 h at 70% zinc utilization with 10 µm zinc. In addition, the Zn-APM||Zn 0.58 V 2 O 5 ·H 2 O full cell exhibits 80% capacity retention after 500 cycles at a loading of 8.1 mg cm −2 .}, archive = {J_ANGEW}, author = {Zeping Liu and Guangning Xu and Yu Zhang and Meng Li and Haoran Li and Jiachi Zhang and Jie Hu and Tiesong Lin and Naiqing Zhang}, doi = {10.1002/anie.202501960}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202501960}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling zinc stripping and molecular engineering for high-performance zinc anode}, volume = {64}, year = {2025}, }
• (2025). Unexpected redox role of WO3 in V2O5-WO3/TiO2 catalysts for selective reduction of NO by forming V–W dinuclear sites. ANGEW, 64(28), e202501957. (www)

  @article{ , abstract = {Promoters can greatly improve the activity of catalysts; however, the mechanism by which they interact with the primary catalyst to enhance catalytic activity is not always clear. It has been widely demonstrated that WO 3 in V 2 O 5 -WO 3 /TiO 2 catalysts acts as a promoter to enhance the surface acidity and regulate the dispersion of active V 2 O 5 species, while it is believed that the redox process takes place entirely at the V sites in the selective catalytic reduction of NO x with NH 3 (NH 3 -SCR). Here, by combining in situ spectroscopic measurements and density functional theory (DFT) calculations, we validate that the WO 3 directly participates in the oxidative activation of NH 3 , and hence explicitly exerts a redox effect in NH 3 -SCR by forming V–W dinuclear sites with V 2 O 5 . This study sheds new light on a long-standing puzzle regarding the role of WO 3 as a promoter and hence advances the understanding of the working principle of V 2 O 5 -WO 3 /TiO 2 catalysts.}, archive = {J_ANGEW}, author = {Zhuocan Li and Rucheng Duan and Xin Wang and Yu Fu and Meng Gao and Hongwei Li and Guangzhi He and Hong He}, doi = {10.1002/anie.202501957}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202501957}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unexpected redox role of WO3 in V2O5-WO3/TiO2 catalysts for selective reduction of NO by forming V–W dinuclear sites}, volume = {64}, year = {2025}, }
• (2025). Boosting urea electrosynthesis via asymmetric oxygen vacancies in zn-doped Fe2O3 catalysts. ANGEW, 64(28), e202501830. (www)

  @article{ , abstract = {Urea electrosynthesis from CO 2 and nitrate (NO 3 − ) provides an attractive pathway for storing renewable electricity and substituting traditional energy-intensive urea synthesis technology. However, the kinetics mismatching between CO 2 reduction and NO 3 − reduction, as well as the difficulty of C─N coupling, are major challenges in urea electrosynthesis. Herein, we first calculated the free energy of *CO, *OCNO, and *NOH formation over defect-rich Fe 2 O 3 catalysts with different metal dopants, which showed that Zn dopant was a promising candidate. Based on the theoretical study, we developed Zn-doped defect-rich Fe 2 O 3 catalysts (Zn–Fe 2 O 3 /O V ) containing asymmetric Zn–O V –Fe sites. It exhibited an outstanding urea faradaic efficiency of 62.4% and the remarkable recycling stability. The production rate of urea was as high as 7.48 mg h −1 mg cat −1 , which is higher than most of the reported works to date. Detailed control experiments and in situ spectroscopy analyses identified *OCNO as a crucial intermediate for C─N coupling. The Zn–Fe 2 O 3 /O V catalyst with asymmetric Zn–O V –Fe sites showed enhanced *CO coverage and promoted *OCNO formation, leading to high efficiency toward urea production.}, archive = {J_ANGEW}, author = {Xinning Song and Xiangyuan Jin and Tianhui Chen and Shoujie Liu and Xiaodong Ma and Xingxing Tan and Ruhan Wang and Libing Zhang and Xing Tong and Ziwei Zhao and Xinchen Kang and Qinggong Zhu and Qingli Qian and Xiaofu Sun and Buxing Han}, doi = {10.1002/anie.202501830}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202501830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting urea electrosynthesis via asymmetric oxygen vacancies in zn-doped Fe2O3 catalysts}, volume = {64}, year = {2025}, }
• (2025). Boosting initial coulombic efficiency in li-rich mn-based cathodes by tuning orbital hybridization. ANGEW, 64(28), e202501777. (www)

  @article{ , abstract = {Li-rich manganese-based oxides (LRMO) are promising cathode materials for next-generation lithium-ion batteries due to their high-capacity and low-cost merits. However, the low initial coulombic efficiency (ICE) and irreversible oxygen release of LRMO severely hinder their commercialization processes. Here, we employ glyoxal treatment to modulate the hybridization between transition metal (TM) 3 d and oxygen (O) 2 p orbitals in LRMO. This approach is found to reduce the Co/Mn t 2g -O 2 p hybridization in LRMO while simultaneously activating the Co 2+ /Co 3+ redox below the Fermi level. Our findings demonstrate that tuning TM 3 d -O 2 p orbital hybridization can be a viable approach to improve the ICE of LMRO. Specifically, the ICE of LRMO can be elevated from 85.3% to 102.5%, and a high specific capacity of 291.2 mAh g −1 can be achieved at 0.1 C. Moreover, the treated LRMO cathodes exhibit significantly enhanced capacity retention.}, archive = {J_ANGEW}, author = {Tao Zeng and Ziqin Jiao and Xiaoyu Gao and Maolin Yang and Xiaohu Wang and Wenguang Zhao and Wei Tang and Mihai Chu and Ze He and Jinqi Li and Zhongyuan Huang and Guojie Chen and Ziwei Chen and Rui Wang and Liming Wang and Junrong Zhang and Lunhua He and Yuguang Pu and Yinguo Xiao}, doi = {10.1002/anie.202501777}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202501777}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting initial coulombic efficiency in li-rich mn-based cathodes by tuning orbital hybridization}, volume = {64}, year = {2025}, }
• (2025). Supramolecular ion channels to engineer zn2+ ion transport mediated chemical-to-optical signal transduction. ANGEW, 64(28), e202501634. (www)

  @article{ , abstract = {Artificial ion channels have significant potential for various applications, including molecular communication, bio-sensing, and constructing artificial cells. In this report, we demonstrated the development of a molecular communication system that transports ions across the lipid bilayers via the formation of supramolecular ion channels and harnesses chemical reactions to overcome the challenges of executing signal-processing functions at the molecular level. The potent ionophore self-assembles into nanochannels within the lipid bilayers and selectively transports Zn 2+ ions. The movement of Zn 2+ ions through these supramolecular ion channels enables the in situ generation of a water-soluble catalytic system with tyrosine. This catalytic system promotes esterase-like activity, generating fluorescent reporters from non-fluorescent ester-based compounds within the intravesicular environment. Furthermore, this process indicates the formation of a three-input AND logic gate in the fluorescence mode, allowing the monitoring of the chemical-to-optical signal amplification process akin to biological counterparts. Developing these molecular communication systems to replicate the complexity of natural cellular processes opens up exciting opportunities for designing advanced biomimetic tools and exploring the fundamental principles underlying cellular communication.}, archive = {J_ANGEW}, author = {Soumya Srimayee and Biswa Mohan Prusty and Mrinal Kanti Kar and Mathias Winterhalter and Debasis Manna}, doi = {10.1002/anie.202501634}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202501634}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular ion channels to engineer zn2+ ion transport mediated chemical-to-optical signal transduction}, volume = {64}, year = {2025}, }
• (2025). Supramolecular charge-transfer approach for tunable and efficient circularly polarized delayed fluorescence and phosphorescence. ANGEW, 64(28), e202501330. (www)

  @article{ , abstract = {Achieving efficient circularly polarized luminescence (CPL) with a high luminescence dissymmetry factor (|g lum |) in purely organic systems is a vibrant and rapidly evolving field of research. Recently, the growing interest in ambient organic phosphors has offered a promising alternative for achieving CPL with remarkable quantum yields by utilizing triplet states. While supramolecular charge-transfer (CT) interactions are well-established to improve |g lum | by enhancing magnetic transition dipole components, their application to triplet-harvesting organic systems remains unexplored. In this context, our current work introduces a supramolecular strategy to achieve highly efficient and tunable circularly polarized thermally activated delayed fluorescence (TADF) and phosphorescence by the involvement of intermolecular triplet CT states. Through-space intermolecular CT interactions between heavy atom-substituted bis-chromophoric pyromellitic diimides (PmDIs) (acceptors) and achiral phenyl carbazole derivatives (donors) enable one of the most efficient circularly polarized delayed luminescent systems, characterized by a high quantum yield (∼46%) and a significant |g lum | ∼3.6 × 10⁻ 2 . Additionally, the modularity of this non-covalent design allows for the tuning of emission from the orange to deep-red regions by incorporating various donors. The strategy presented here opens new avenues for designing efficient CPL-active organic phosphors.}, archive = {J_ANGEW}, author = {Swadhin Garain and Anju Ajayan Kongasseri and Sopan M. Wagalgave and Rishika Konar and Darshana Deb and K. S. Narayan and Pralok K. Samanta and Subi J. George}, doi = {10.1002/anie.202501330}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202501330}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular charge-transfer approach for tunable and efficient circularly polarized delayed fluorescence and phosphorescence}, volume = {64}, year = {2025}, }
• (2025). A simple quinoid building block for polymer semiconductors with tunable polarity and high n-type thermoelectric performance. ANGEW, 64(28), e202501196. (www)

  @article{ , abstract = {π-Conjugated polymers with deep-positioned lowest unoccupied molecular orbital (LUMO) level and large electron mobility are highly pursued as n-type organic thermoelectric materials. Herein, we synthesized a simple structured electron-deficient quinoid building block, thieno[3,2- b ]thiophene-2,5-dione (TTD), via one step from a low-cost starting material. Based on TTD, polymers PQD and PQTD were successfully developed, featuring remarkably low-lying LUMO levels (−3.91 eV for PQD and −3.73 eV for PQTD), which greatly facilitate n-doping process. Unexpectedly, it was found that charge carrier polarity of PQD and PQTD can be tuned from p-type to ambipolar and finally to n-type in organic field-effect transistors after thermal treatment, an unprecedented phenomenon in polymer semiconductors. Organic thermoelectric devices based on n-doped PQD films showed an excellent electrical conductivity up to 19.1 S cm −1 and a power factor of 36.7 µW m −1 K −2 . To the best of our knowledge, this PF value ranks the highest reported to date for n-doped quinoid-based polymers. This work underscores the great potential of structurally simple and readily accessible electron-deficient quinoid TTD for the development of high-performing n-type polymer semiconductors.}, archive = {J_ANGEW}, author = {Weipeng Sun and Sergio Gámez-Valenzuela and Xiage Zhang and Jin-Woo Lee and Zhicheng Zhong and Peng Wang and Suxiang Ma and Hanqiang Wang and Bumjoon J. Kim and Xugang Guo}, doi = {10.1002/anie.202501196}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202501196}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A simple quinoid building block for polymer semiconductors with tunable polarity and high n-type thermoelectric performance}, volume = {64}, year = {2025}, }
• (2025). Tumor-specific on-site activation of cisplatin via cascade catalytic-redox reactions for highly efficient chemo-immunotherapy. ANGEW, 64(28), e202500996. (www)

  @article{ , abstract = {The therapeutic efficiency of platinum drugs is always limited by low utilization, side effects, and Pt-resistance. Herein, a double-lock protected Pt II nanomedicine named PtNP@Cu has been developed, which performs cascade unlocking of dechlorinated cisplatin ( DP ) via catalytic-redox reactions, thus achieving tumor-specific “on-site” activation of cisplatin ( cDDP ) in the nucleus accompanied with substantial induction of ferroptosis of cancer cells. This design avoids the premature release of active Pt II species in normal cells or in the cytoplasm of cancer cells before reaching nucleus, thereby ensuring maximum amplification of Pt-DNA crosslinking with tumor-specificity. Meanwhile, substantial GSH depletion and ROS production induced by cascade catalytic-redox reactions results in ferroptosis of cancer cells, which further reduces GSH-mediated cDDP detoxification, overcomes Pt-resistance, and enhances immunogenicity, ultimately realizing highly efficient tumor-specific chemotherapy and antitumor immunity in vivo. This work provides a new strategy for effectively and comprehensively addressing the issues of low utilization, side effects, and drug resistance problems of platinum drugs, which is also promising for chemo-immunotherapy.}, archive = {J_ANGEW}, author = {Gang-Gang Yang and Bin Liu and Wei Liu and Lan Zhang and Can Ke and Xinya Han and Qian Cao and Zong-Wan Mao}, doi = {10.1002/anie.202500996}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202500996}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tumor-specific on-site activation of cisplatin via cascade catalytic-redox reactions for highly efficient chemo-immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Iron-catalyzed radical allylic substitution of unprotected allylic alcohols. ANGEW, 64(28), e202500781. (www)

  @article{ , abstract = {Allylic substitution reactions are essential in organic synthesis, enabling the transformation of allylic reagents into diverse alkenes. Traditional methods, which typically operate through ionic pathways, often require substrate preactivation to address high C─O bond dissociation energies, leading to challenges in regioselectivity and limited substrate compatibility. Here, we introduce an iron-catalyzed radical pathway for allylic substitution that directly activates unprotected allylic alcohols, leveraging the redox and oxophilic properties of low-valent iron to promote selective C─O bond cleavage and allylic transposition. This radical approach achieves high regio- and stereoselectivity, providing access to a broad array of di- , tri- , and tetra -substituted alkenes with moderate to excellent yields and exceptional E/Z selectivity. Mechanistic studies confirm that the iron catalyst generates radical intermediates and mediates efficient dehydroxylation, enabling this direct transformation without protective groups or Lewis acid activators. The method's versatility is demonstrated through a broad substrate scope, including complex natural derivatives and functionalized alkyl halides, along with successful gram-scale synthesis and downstream derivatization. This iron-catalyzed radical pathway offers a sustainable and efficient alternative to conventional ionic methods, expanding the scope of allylic substitutions and advancing radical-based methodologies in synthetic chemistry.}, archive = {J_ANGEW}, author = {Gang Liu and Ke Gao and Tianbing Yao and Hui Hu and Zhaobin Wang}, doi = {10.1002/anie.202500781}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202500781}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron-catalyzed radical allylic substitution of unprotected allylic alcohols}, volume = {64}, year = {2025}, }
• (2025). Noncovalent synthesis of topological heterostructures using a site-selective electrostatic co-assembly strategy. ANGEW, 64(28), e202500166. (www)

  @article{ , abstract = {Heterostructured nanomaterials composed of heterogeneous zones with dramatically different chemical and/or physical properties have attracted significant attention. However, achieving controllable synthesis of heterostructures integrated with segments of different stiffness and morphologies has been highly challenging, limiting their applications. Herein, a site-selective electrostatic co-assembly strategy was developed to rationally fabricate topological heterostructures (THSs) containing rigid and flexible segments with different chemical compositions and morphologies. Cationic organometallic complexes have been employed to prepare 1D crystalline supramolecular polymers (SPs), followed by electrostatic co-assembly with oppositely charged block copolymers (BCPs) of poly(ethylene glycol)- block -poly(acrylic acid). It has been found that the BCPs could interact and co-assemble with the complexes in SPs in situ at some specific sites bearing positively charged groups to form nanofiber-like moieties. The co-assembled nanofibers are connected to the intact parts of SPs, resulting in THSs composed of nanofibers and intact parts of SPs. The position of the defect sites on SPs and the dimension of SPs could be finely regulated by performing thermal annealing and/or sonication treatments, further enriching the architectures of the co-assembled THSs. This study unveils new topologies that exhibit enhanced higher-order structural complexity in the realm of supramolecular nanostructures, enabling the exploration of their properties and applications.}, archive = {J_ANGEW}, author = {Zhen Geng and Ki Ip and Priscilla Lok-Yi Chiu and Eric Ka-Ho Wong and Vivian Wing-Wah Yam}, doi = {10.1002/anie.202500166}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202500166}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Noncovalent synthesis of topological heterostructures using a site-selective electrostatic co-assembly strategy}, volume = {64}, year = {2025}, }
• (2025). High-performance perovskite solar cells via 3D covalent organic frameworks: Enhanced efficiency through precision interface engineering. ANGEW, 64(28), e202500163. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs), a class of porous polymers with tunable 2D or 3D structures, have drawn significant attention for their exceptional versatility across various applications. Recently, the integration of COFs into perovskite solar cells (PSCs) has emerged as a promising strategy to address critical challenges, such as instability, interfacial recombination losses, and lead-associated environmental risks. Enhanced charge transport channels, passivation of defects, and customizable molecule architectures are some of the special benefits that COFs offer. In this study, we used Schiff base reactions to create two donor–acceptor (D-A) type COFs with an 8+2 connection motif, which were integrated into PSC self-assembled (SAM) layers. According to characterizations and theoretical calculations, COFs not only effectively optimize the energy level of the ITO/SAM substrate but also passivate perovskite defects and suppress defect-assisted recombination in PSC devices. These modifications significantly enhanced carrier transport and extraction, resulting in an increase in power conversion efficiency (PCE) from 22.57% to 25.20% (DP-BE) and 24.21% (DP-DBE). This work highlights the potential of COFs as multifunctional modifiers for interfacial engineering in PSCs, offering a promising route to improve device performance and stability.}, archive = {J_ANGEW}, author = {Shanyue Wei and Weichun Pan and Jia Liu and Jihuai Wu and Yiming Xie and Xiaowei Wu and Can-Zhong Lu}, doi = {10.1002/anie.202500163}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202500163}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance perovskite solar cells via 3D covalent organic frameworks: Enhanced efficiency through precision interface engineering}, volume = {64}, year = {2025}, }
• (2025). On-demand ligate and release strategy based on photoclick reaction in tandem with pd-mediated deallylation. ANGEW, 64(28), e202425479. (www)

  @article{ , abstract = {The development of chemoselective tools that can conjugate, modify, and decouple chemical groups from biomacromolecules has enabled the study of biological processes at increasing levels of fidelity. Until recently, these tools can either couple chemical entities to biomacromolecules or decouple them, but not both. A method that can perform these functions in distinct steps on demand would be highly useful. To that end, we devised a new-to-nature strategy by bringing together and modifying two biocompatible transformations. In this new strategy, ligation is accomplished via the photoclick reaction between an allenyl motif with 9,10-phenanthrenequinone which installs an allyl group at the site of conjugation. This allyl group can then be selectively utilized as a handle for phenolic release via Pd-mediated deallylation. As a proof of concept, we demonstrated its utility in the selective labeling and delabeling of model protein scaffolds and cellular matrix. This multifunctional method paves the way for a controllable “ligate and release” strategy that enables on-demand visualization of biological entities but with an in built release mechanism to restore their original state.}, archive = {J_ANGEW}, author = {Boon Shing Loh and Hanqing Pang and Soh Wah Yong and Cheng Weng and Wee Han Ang}, doi = {10.1002/anie.202425479}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202425479}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-demand ligate and release strategy based on photoclick reaction in tandem with pd-mediated deallylation}, volume = {64}, year = {2025}, }
• (2025). The ATM kinase inhibitor AZD0156 is a potent inhibitor of plasmodium phosphatidylinositol 4-kinase (PI4Kβ) and is an attractive candidate for medicinal chemistry optimization against malaria. ANGEW, 64(28), e202425206. (www)

  @article{ , abstract = {New compounds targeting human malaria parasites are critical for effective malaria control and elimination. Here, we pursued the imidazoquinolinone AZD0156 (MMV1580483), a human ataxia-telangiectasia mutated (ATM) kinase inhibitor that completed Phase I clinical trials as an anticancer agent. We validated its in vitro activity against the two main forms of the Plasmodium falciparum parasite in the human host, viz. the asexual blood (symptomatic) stage and sexual gametocyte (transmission) stage. Resistance selection, cross-resistance, biochemical, and conditional knockdown studies revealed that AZD0156 inhibits P. falciparum phosphatidylinositol 4-kinase type III beta ( Pf PI4Kβ), a clinically-validated target for the treatment of malaria. Metabolic perturbations, fixed-ratio isobolograms, killing kinetics and morphological evaluation correlated AZD0156 inhibition with other known PI4Kβ inhibitors. The compound showed favorable in vivo pharmacokinetic properties and 81% antimalarial efficacy (4 × 50 mg kg −1 ) in a P. berghei mouse malaria infection model. Importantly, a cleaner biochemical profile was measured against human kinases (MAP4K4, MINK1) implicated in embryofoetal developmental toxicity associated with the Pf PI4Kβ inhibitor MMV390048. This improved kinase selectivity profile and structural differentiation from other PI4Kβ inhibitors, together with its multistage antiplasmodial activity and favorable pharmacokinetic properties, makes AZD0156 an attractive candidate for target-based drug repositioning against malaria via a medicinal chemistry optimization approach.}, archive = {J_ANGEW}, author = {John G. Woodland and Dina Coertzen and Kathryn J. Wicht and Virginia Franco Hidalgo and Charisse Flerida A. Pasaje and Luiz C. Godoy and Tarrick Qahash and Mmakwena M. Mmonwa and Godwin A. Dziwornu and Lynn Wambua and Sarah Harries and Constance M. Korkor and Mathew Njoroge and Liezl Krugmann and Dale Taylor and Meta Leshabane and Henrico Langeveld and Tayla Rabie and Janette Reader and Mariëtte van der Watt and Nelius Venter and Erica Erlank and Ayesha S. Aswat and Lizette L. Koekemoer and Tomas Yeo and Jin H. Jeon and David A. Fidock and Francisco Javier Gamo and Sergio Wittlin and Jacquin C. Niles and Manuel Llinas and Lauren B. Coulson and Lyn-Marié Birkholtz and Kelly Chibale}, doi = {10.1002/anie.202425206}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202425206}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The ATM kinase inhibitor AZD0156 is a potent inhibitor of plasmodium phosphatidylinositol 4-kinase (PI4Kβ) and is an attractive candidate for medicinal chemistry optimization against malaria}, volume = {64}, year = {2025}, }
• (2025). On-surface synthesis of nanographenes through domino cyclization reactions. ANGEW, 64(28), e202425167. (www)

  @article{ , abstract = {On-surface synthesis has emerged as a powerful method to synthesize nanographenes that are difficult to obtain through the solution chemistry, but the number of available reactions is still highly limited. In this study, we demonstrate an unprecedented on-surface domino cyclization of bis{2-(7-formylnaphthalen-2-yl)phenyl}diacetylene, leading to dibenzo[ hi , st ]ovalene and peryleno[2,1,12,11- fghij ]pentaphene through a sequence of 1) cycloisomerization of diaryldiacetylene moieties, 2) oxidative cyclodehydrogenation, and 3) reductive cyclization of formyl groups. The structures of these nanographenes and other cyclized products were unambiguously elucidated by using scanning tunneling microscopy directly on Au(111). Moreover, their electronic properties were investigated by scanning tunneling spectroscopy combined with density functional theory calculations. Our findings offer new insights into the on-surface cyclization reactions, providing an effective strategy for synthesizing a wider variety of carbon nanostructures.}, archive = {J_ANGEW}, author = {Shijie Sun and Qingyan Li and Takatsugu Onishi and Goudappagouda and Hangjing Zhou and Lei Gao and Yoshinori Okada and Jianchen Lu and Akimitsu Narita and Jinming Cai}, doi = {10.1002/anie.202425167}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202425167}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-surface synthesis of nanographenes through domino cyclization reactions}, volume = {64}, year = {2025}, }
• (2025). Aptamer as a molecular tethering agent induces PrPC aggregation and degradation to inhibit melanoma proliferation. ANGEW, 64(28), e202425051. (www)

  @article{ , abstract = {Melanoma, a malignant tumor originating from melanocytes, is the most aggressive and deadly form of skin cancer. Previous studies have revealed that the cellular prion protein (PrP C ) is frequently overexpressed in melanoma, contributing to tumor progression. This study presents the first proof of concept evidence that nucleic acid aptamers can be used to construct a molecular tethering agent that regulates PrP C protein levels by inducing membrane-bound PrP C aggregation for antimelanoma therapy. Using a screening strategy combining cell-SELEX and cell-internalization SELEX, we obtained ssDNA aptamer, TT-1e, specifically binding to melanoma cells and tissues. We identified that the binding site of TT-1e is located at the octapeptide repeat region of glycosylated PrP C . Based on the binding characteristics of TT-1e, we engineered an aptamer-based molecular tethering agent TTe-TTe. We found that TTe-TTe induces aggregation of cell surface PrP C , promoting its internalization and facilitating its lysosomal degradation. This process resulted in the inhibition of AKT pathway activation. Importantly, in vivo studies confirmed the ability of TTe-TTe to target melanoma xenografts and suppress tumor growth through this unique mechanism. Our study presents a promising strategy for targeted melanoma therapy and introduces a paradigm-shifting approach for manipulating protein levels using aptamers as molecular tethering agents.}, archive = {J_ANGEW}, author = {Tiantian Xie and Yibin Zhang and Neng Ling and Yijun Yuan and Weibin Liu and Junxiao Guo and Xianhua Wei and Tianhuan Peng and Zhiyan Wang and Jing Dai and Wenjing Chen and Ming Yan and Xiaoqiu Wu and Wencan Wu and Mao Ye and Weihong Tan}, doi = {10.1002/anie.202425051}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202425051}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aptamer as a molecular tethering agent induces PrPC aggregation and degradation to inhibit melanoma proliferation}, volume = {64}, year = {2025}, }
• (2025). Design strategies based on electronic interactions for effective catalysts in Lithium–Sulfur batteries. ANGEW, 64(28), e202425037. (www)

  @article{ , abstract = {Lithium–sulfur batteries (LSBs) are considered promising next-generation batteries due to their high energy density (>500 W h kg −1 ). However, LSBs exhibit an unsatisfactory energy density (<400 W h kg −1 ) and cycle life (<300 cycles) because of the shuttle effect caused by soluble lithium polysulfide (LiPS) intermediates and the sluggish conversion reaction kinetics caused by insulating sulfur (S 8 ) and lithium sulfide (Li 2 S). Although various types of catalysts, including metal-based compounds to single-atom catalysts, have been reported to address these issues, most catalysts exhibited limited catalytic activity under practical lean electrolyte conditions (<5 µL mg −1 ). A comprehensive understanding of the synthetic strategy and catalytic mechanism of catalysts is essential for their design, but understanding the electronic effects of the catalysts and LiPS is more important. Furthermore, the electronic design of these catalysts is not well understood. In this review, we introduce the catalytic mechanisms in LSBs and discuss catalyst design strategies in terms of electronic effects on the interactions between reactants and catalysts, with a primary focus on heterogeneous catalytic systems. We additionally consider how the electronic property of homogeneous systems, particularly redox mediators, affects catalytic behavior under lean electrolyte conditions and propose future research directions for catalyst development in LSBs.}, archive = {J_ANGEW}, author = {Donghyeok Son and Cheol-Young Park and Jinuk Kim and Won-Gwang Lim and Seoa Kim and Jinwoo Lee}, doi = {10.1002/anie.202425037}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202425037}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design strategies based on electronic interactions for effective catalysts in Lithium–Sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Lysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals. ANGEW, 64(28), e202424832. (www)

  @article{ , abstract = {The bromodomain extra-terminal (BET) family of proteins are valuable therapeutic targets for cancer and other diseases. The adverse events of current pan-BET inhibitors (BETi) make the development of BET BD1- or BD2-selective inhibitors as a fresh avenue to overcome safety challenges. On the basis of various lysine-reactive covalent warheads herein we report a set of activity-based probes (ABPs; P3 – P7 ) capable of global profiling of ligandable lysines within bromodomains (BRDs) in live cells and animals. Chemoproteomic experiments with P7, which utilizes 2-ethynylbenzaldehyde (EBA), identified 16 endogenous BRDs, thus giving a global landscape of ligandable lysines in BRDs. By further introducing EBA and salicylaldehyde into PLX51107 (a noncovalent BETi), we generated lysine-reactive, irreversible ( BDS1 – 4 ) and reversible ( BDS5 – 6 ) BD1 covalent inhibitors. Mass spectrometry and X-ray crystallography confirmed the successful covalent engagement between EBA and K91 near the acetylated lysine (Kac)-binding site of BD1 in BRD4. BDS4 showed 104-fold selectivity for BD1 over BD2 with prolonged anticancer effects. Importantly, BDS4 retained robust activity against fibrosis in cells and animals when compared to RVX-208 (a reported BD2-selective noncovalent inhibitor), which showed only marginal effects. Our work serves as a useful tool to delineate distinct functions of BD1 and BD2 in future studies.}, archive = {J_ANGEW}, author = {Tao Li and Wenjie Zhang and Yiqing Wang and Guangyu Xu and Fengfei Miao and Peng Chen and Guanghui Tang and Xiaotong Ze and Jing Xiang and Jiaqian Yan and Miaomiao Wang and Min Liu and Xiaojie Wang and Wei Tang and Fan Yi and Zhi-Min Zhang and Rui Wang and Shao Q Yao and Yusheng Xie}, doi = {10.1002/anie.202424832}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202424832}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals}, volume = {64}, year = {2025}, }
• (2025). Electronic structure origins of distinct hydrogenation activities observed for linear and bent bimetallic μ-nitrides. ANGEW, 64(28), e202424571. (www)

  @article{ , abstract = {Hydrogenation of metal nitrides is of particular interest due to the direct relevance to Haber–Bosch ammonia synthesis. Notably, for all bi- and multi-nuclear bridging nitrides reported thus far, only those featuring bent M─N─M cores can react with dihydrogen (H 2 ) and related H 2 -derived species, while the vast majority of linear M─N─M congeners cannot. Herein, we present a detailed electronic-structure study of prototypical bimetallic bent μ -nitrides [Cp*Fe IV ( μ -SEt) 2 ( μ -N)Fe IV Cp*][PF 6 ] ( 1 , Cp* = η 5 -C 5 Me 5 ) and [Cp*Co III ( μ -SAd)( μ -N)Co III Cp*] ( 3 , Ad = adamantyl) and linear μ -nitride [(TPP)Fe IV ( μ -N)Fe IV (TPP)][PF 6 ] ( 2 , TPP 2− = 5,10,15,20-tetraphenylporphinato), as well as μ -imide [Cp*Co III ( μ -SAd)( μ -NH)Co III Cp*][BPh 4 ] ( 4 ), using various spectroscopic techniques, in particular, 15 N solid-state nuclear magnetic resonance, coupled with density functional theory calculations. An in-depth analysis of their distinct 15 N shielding tensors revealed that bent μ -nitrides invariably possess a high-lying proton-accepting molecular orbital (MO) and a low-lying electron-accepting MO. These electronic-structure features are key to the bent μ -nitrides affecting hydrogenolysis via either two-electron oxidation of H 2 or H 2 heterolysis. However, because of symmetry, linear μ -nitrides lack potent proton-accepting MOs, which rationalizes their disparate hydrogenation activities.}, archive = {J_ANGEW}, author = {Mengdi Huang and Luyang Sun and Zihe Song and Haowei Chen and Pan Gao and Guangjin Hou and Georgi L. Stoychev and Baomin Wang and Dawei Yang and Jingping Qu and Shengfa Ye}, doi = {10.1002/anie.202424571}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202424571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic structure origins of distinct hydrogenation activities observed for linear and bent bimetallic μ-nitrides}, volume = {64}, year = {2025}, }
• (2025). Silylchromium-catalyzed selective semihydrogenation of undirected allenes by sila-metalation and β-silyl elimination. ANGEW, 64(28), e202424273. (www)

  @article{ , abstract = {The semihydrogenation of simple allenes remains an issue because of the difficulty in controlling of selectivity without coordination assistance from directing groups, wherein over-hydrogenated alkanes and E / Z -mixed stereo- and regio-isomers can be potentially formed. We report here an electron-rich cyclic (alkyl)(amino)carbene (CAAC)-phosphine-ligated chromium(III) complex serving as precatalyst in promoting the selective semihydrogenation of undirected allenes by forming active silylchromium species. The semihydrogenation allows the selective addition of H 2 to the less substituted and electron-rich alkyl-substituted C═C bonds of allenes while enabling the suppression of competitive over-hydrogenation, proving generally to form trisubstituted E -alkenes in high chemo-, regio-, and stereoselectivity. By this CAAC-phosphine-Cr-catalyzed selective semihydrogenation, unsaturated nitro, nitrile, alkenyl, and hydrogenation-sensitive bromide, chloride, and fluoride were compatible with various substitution environments. The in situ forming silylchromium as active catalyst by reaction of low-valent chromium complex with chlorosilane was established by studying the catalytic and stoichiometric reactivity of this species in the semihydrogenation. Deuterium labeling experiments, HRMS, XPS, EPR, and magnetic susceptibility analysis of the related intermediates and theoretical studies support a pathway involving sila-metalation of allene and β-silyl elimination processes with silyl as noninnocent ligand, leading to the E -alkene products.}, archive = {J_ANGEW}, author = {Zheng Luo and Linhong Long and Shuaiyong Zhao and Xiaoyu Zhang and Yong Peng and Meiming Luo and Hui Chen and Xiaoming Zeng}, doi = {10.1002/anie.202424273}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202424273}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Silylchromium-catalyzed selective semihydrogenation of undirected allenes by sila-metalation and β-silyl elimination}, volume = {64}, year = {2025}, }
• (2025). Dopant and exfoliation induced simultaneous modification of charge density and C─C coupling sites for efficient CO2 photoreduction to ethylene. ANGEW, 64(28), e202423471. (www)

  @article{ , abstract = {The photochemical conversion of CO 2 into C2+ products has emerged as an attractive method for synthesizing valuable chemicals and fuels using abundant solar energy. However, the challenge lies in enhancing the efficiency and selectivity of C2+ product formation. In this study, we employed a heteroatom doping strategy to optimize the photocatalytic parameters and achieve excellent efficiency and selectivity in the photocatalytic CO 2 reduction to C2+ product formation. Our experimental analysis revealed that the local electronic structure of the catalyst, modified by In-doping, enables enhanced efficiency. Additionally, the incorporation of Cu facilitates the coupling of C1 intermediates, resulting in excellent selectivity towards C2+ products. The CO 2 reduction performance is further enhanced through exfoliation, which increases the exposure of active sites and extends the charge carrier lifetime by reducing the charge diffusion length. We report that the rate of formation of C 2 H 4 reached 54.3 µmol·h −1 ·g −1 with an outstanding selectivity of 91% over the exfoliated CuIn-doped AgBiP 2 S 6 catalyst. By elucidating the role of heteroatom doping and exfoliation in enhancing both the efficiency and selectivity of C2+ product formation, our study contributes to advancing the development of sustainable and efficient photocatalytic CO 2 conversion technologies.}, archive = {J_ANGEW}, author = {Kousik Das and Subhajit Chakraborty and Siddhi Kediya and Ashutosh Kumar Singh and Risov Das and Soumi Mondal and Mohd Riyaz and Devender Goud and Nilutpal Dutta and Chathakudath P. Vinod and Sebastian C. Peter}, doi = {10.1002/anie.202423471}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202423471}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dopant and exfoliation induced simultaneous modification of charge density and C─C coupling sites for efficient CO2 photoreduction to ethylene}, volume = {64}, year = {2025}, }
• (2025). Theodor förster: Life and FRET from 1933 to 1951. a viewpoint from the archives. ANGEW, 64(28), e202416843. (www)

  @article{ , abstract = {FRET stands for Förster resonance energy transfer. While much is known about resonance energy transfer, much less is known about Förster–apart from the fact that he was the one who translated FRET from a theoretical phenomenon into a broadly usable method for investigating and understanding biomolecular interactions on the nanoscale. Arguably, a major reason for the limited recognition of Theodor Förster is his scientific career during the Nazi time in Germany about which little is documented. By reviewing documents from different archives, this Viewpoint Article –on the occasion of the 50 th anniversary of his death–sheds some light on Förster's life from 1933 to 1951 and describes how a young scientist struggled during dark times in history.}, archive = {J_ANGEW}, author = {Frank Eckart and Hans-Gerd Löhmannsröben and Niko Hildebrandt}, doi = {10.1002/anie.202416843}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {28}, pages = {e202416843}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Theodor förster: Life and FRET from 1933 to 1951. a viewpoint from the archives}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Ultra-stable gold nanoparticles with tunable surface characteristics. ANGEW, 64(27), e202582701. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582701}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202582701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Ultra-stable gold nanoparticles with tunable surface characteristics}, volume = {64}, year = {2025}, }
• (2025). Front cover: AI.zymes – A modular platform for evolutionary enzyme design (Angew. chem. int. ed. 27/2025). ANGEW, 64(27), e202512748. (www)

  @article{ , archive = {J_ANGEW}, author = {Lucas P. Merlicek and Jannik Neumann and Abbie Lear and Vivian Degiorgi and Moor M. de Waal and Tudor-Stefan Cotet and Adrian J. Mulholland and H. Adrian Bunzel}, doi = {10.1002/anie.202512748}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202512748}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Front cover: AI.zymes – A modular platform for evolutionary enzyme design (Angew. chem. int. ed. 27/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Zinc coordination-polymer-mediated self-assembly of nanoparticles into ‘Brick-and-mortar’ membranes for hydrogen separation”. ANGEW, 64(27), e202511147. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202511147}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202511147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Zinc coordination-polymer-mediated self-assembly of nanoparticles into ‘Brick-and-mortar’ membranes for hydrogen separation”}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Benzotrifuran-based covalent organic frameworks for artificial photosynthesis of H2O2 from H2O, o2 and sunlight (Angew. chem. int. ed. 27/2025). ANGEW, 64(27), e202510011. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhenwei Zhang and Yuxin Hou and Shanshan Zhu and Liuliu Yang and Yinghui Wang and Huijuan Yue and Hong Xia and Gang Wu and Shuo-Wang Yang and Xiaoming Liu}, doi = {10.1002/anie.202510011}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202510011}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Benzotrifuran-based covalent organic frameworks for artificial photosynthesis of H2O2 from H2O, o2 and sunlight (Angew. chem. int. ed. 27/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Rare earth single-atomic hybrid glasses for near-infrared II optical waveguides (Angew. chem. int. ed. 27/2025). ANGEW, 64(27), e202510009. (www)

  @article{ , archive = {J_ANGEW}, author = {Meiqi Dai and Bo Zhou and Dongpeng Yan}, doi = {10.1002/anie.202510009}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202510009}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Rare earth single-atomic hybrid glasses for near-infrared II optical waveguides (Angew. chem. int. ed. 27/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Giant birefringence enabled by the highly anisotropic linear IX2- (X=Cl, br) building blocks (Angew. chem. int. ed. 27/2025). ANGEW, 64(27), e202509837. (www)

  @article{ , archive = {J_ANGEW}, author = {Chong-An Chen and Yang Li and Hongbo Huang and Congcong Jin and Bingbing Zhang and Kang Min Ok}, doi = {10.1002/anie.202509837}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202509837}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Giant birefringence enabled by the highly anisotropic linear IX2- (X=Cl, br) building blocks (Angew. chem. int. ed. 27/2025)}, volume = {64}, year = {2025}, }
• (2025). Schirin hanf. ANGEW, 64(27), e202509336. (www)

  @article{ , archive = {J_ANGEW}, author = {Schirin Hanf}, doi = {10.1002/anie.202509336}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202509336}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Schirin hanf}, volume = {64}, year = {2025}, }
• (2025). Masahiko yoshimura. ANGEW, 64(27), e202509139. (www)

  @article{ , archive = {J_ANGEW}, author = {Masahiko Yoshimura}, doi = {10.1002/anie.202509139}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202509139}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Masahiko yoshimura}, volume = {64}, year = {2025}, }
• (2025). Electrochemical synthesis of hydroxylamine. ANGEW, 64(27), e202509053. (www)

  @article{ , abstract = {Hydroxylamine (NH 2 OH) serves as an important industrial feedstock. The conventional production and transportation of NH 2 OH requires harsh conditions. Recently, electrochemical hydrogenation of nitrogen-containing oxidative species, such as nitrate, nitrite, and nitric oxide (NO 3 − /NO 2 − /NO), into NH 2 OH has been developed as a sustainable strategy. However, the over-hydrogenation product of ammonia is preferentially obtained under electroreduction condition. Thus, the rational design of catalysts structure is crucial to selective electrosynthesis of NH 2 OH. In this minireview, we summarize recent advances in electrochemical synthesis of NH 2 OH with emphasis on the design of catalysts structure. Electrochemical synthesis strategy we discussed is categorized by the existence form of product, including indirect electrosynthesis and direct electrosynthesis. Finally, the techno–economic analysis (TEA) of electrochemical NH 2 OH production and outlook of performance improvement strategies are carried out to further guide the optimization of reaction system.}, archive = {J_ANGEW}, author = {Minghao Guo and Yuhan Zhang and Chengying Guo and Yifu Yu}, doi = {10.1002/anie.202509053}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202509053}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical synthesis of hydroxylamine}, volume = {64}, year = {2025}, }
• (2025). Design, synthesis, and application of a family of chiral non-c2-symmetric NHCs with a fused sidechain. ANGEW, 64(27), e202508572. (www)

  @article{ , abstract = {Although a considerable number of chiral nitrogen heterocyclic carbenes (NHCs) have been developed yet it is highly necessary to develop new NHCs bearing multiple sites for facile modifications of both electronic nature and steric hindrance. Herein, we uncover a new family of chiral non-C 2 -Symmetric NHCs with a fused sidechain, whose precursors are synthesized by a simple five-step route. The synthesis includes Pd-catalyzed cross-coupling or nucleophilic addition/oxidation, chiral phosphoric acid-catalyzed asymmetric reduction of 2-aryl-quinolines, bromination at C8, Buchwald–Hartwig amination, and cyclization with methyl orthoformate. Among nine prepared NHCs, YC-NHC8 is the optimal ligand for Cu(I)-catalyzed asymmetric S N 2′ silylation, YC-NHC3 works as the best ligand for Cu(I)-catalyzed enantioselective conjugate silylation of simple α,β-unsaturated amides, and YC-NHC9 serves as the most suitable ligand for copper(I)-catalyzed asymmetric silylation of azadienes. Remarkably, these three reactions are successfully run under a catalyst loading of 0.1 mol%, indicating that YC-NHCs may have the potential to be broadly used in efficient asymmetric transition metal catalysis.}, archive = {J_ANGEW}, author = {Zhen-Xi Cai and Qi Zhang and Tian-Yu Wei and Hu Tian and Jia-Wei Jiang and Zhang-Yi Wei and Liang Yin}, doi = {10.1002/anie.202508572}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202508572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design, synthesis, and application of a family of chiral non-c2-symmetric NHCs with a fused sidechain}, volume = {64}, year = {2025}, }
• (2025). Regulating multifunctional oxygen vacancies for plasma-driven air-to-ammonia conversion. ANGEW, 64(27), e202508240. (www)

  @article{ , abstract = {Current ammonia (NH₃) synthesis is hindered by challenges including N₂ activation, NH₃ separation and process complexity. Here, we report a plasma-electrochemical process for the production of gaseous ammonia from air generated NO x , decoupled from processes employing liquid phase intermediaries such as NO₃⁻ and final product (NH 4 + ). Importantly, this process uses air for scalable ammonia production under ambient conditions and directly produces gaseous NH₃ which facilitates efficient product separation. For NO x reduction to NH₃, we propose a universal strategy combining plasma pretreatment and wet chemical calcination to introduce multifunctional oxygen vacancies. The resulting highly defective Fe₂O₃ nanoparticles on Cu achieves a significant ammonia production rate of 628 nmol·s⁻¹·cm⁻ 2 , along with nearly 100% faradaic efficiency.}, archive = {J_ANGEW}, author = {Wanping Xu and Jiaqian Wang and Tianqi Zhang and Jungmi Hong and Qiang Song and Zhongkang Han and Patrick Cullen}, doi = {10.1002/anie.202508240}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202508240}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating multifunctional oxygen vacancies for plasma-driven air-to-ammonia conversion}, volume = {64}, year = {2025}, }
• (2025). Ultra-stable gold nanoparticles with tunable surface characteristics. ANGEW, 64(27), e202507954. (www)

  @article{ , abstract = {Gold nanoparticles (Au NPs), as a class of functional nanomaterials, have attracted considerable interest for biomedical applications owing to their unique chemical and physical properties. However, colloidal solutions of Au NPs are thermodynamically unstable because of their high surface energy, resulting in poor stability and biocompatibility in physiological environments. Herein, we present a novel strategy for coating Au NPs using in situ polymerization to form a three-dimensional (3D) network polymer shell around each particle. This approach enables the creation of an ultra-stable core-shell structure that effectively improves biocompatibility and stability, even in complex biological environments. The surface characteristics of the polymer shell can also be precisely tailored by carefully selecting the monomers to meet biomedical application requirements. These properties enable prolonged circulation within the bloodstream and enhanced tumor targeting in mice. This strategy offers an ultra-stable, aqueous-based, and biocompatible polymer shell for Au NPs, paving the way for the surface modification of gold nanomaterials in biomedical applications.}, archive = {J_ANGEW}, author = {Jing Wang and Yanbao Xin and Dazhi Chen and Ningning Zhang and Yao Xue and Xinze Liu and Xiang Li and Wenbin Gao and Zheng Hu and Tianmeng Sun and Kun Liu and Wenjing Tian and Bin Xu and Yunfeng Lu}, doi = {10.1002/anie.202507954}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507954}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-stable gold nanoparticles with tunable surface characteristics}, volume = {64}, year = {2025}, }
• (2025). An atmosphere-responsive protective strategy based on deciphering the anode degradation mechanism in Li–CO2 batteries. ANGEW, 64(27), e202507865. (www)

  @article{ , abstract = {Lithium–carbon dioxide (Li–CO 2 ) batteries, with high energy density and CO 2 utilization, are considered a promising candidate for Mars exploration. However, they continue to face challenges such as limited cycle life and significant polarization caused by anode degradation, which is often overlooked and whose underlying mechanism remains unclear. This work revealed the anode failure mechanism, identifying a water-triggered degradation process, which depletes active lithium content, and developed an atmosphere-induced protective strategy. The degradation is triggered by trace water and sustained by the CO 2 component, which results in transforming active lithium into Li 2 CO 3 . Thus, a strategy was provided to respond to the water molecules brought by the semi-hermetic system and high charging voltage. The protective layer was in situ polymerized and can interact with water molecules, leading to further polymerization, thereby inhibiting side reactions, significantly extending the battery's lifespan. The Li–CO 2 batteries can achieve stable cycling exceeding 1000 h, more than twice the time compared to the unprotected case. This study revealed the fundamental mechanism of anode degradation in Li–CO 2 batteries, providing a theoretical basis for the development of subsequent anode protection strategies. Additionally, it offers a viable method for anode protection in Li–CO 2 batteries.}, archive = {J_ANGEW}, author = {Yanze Song and Haotian Qu and Xinru Wu and Yingqi Liu and Bingyi Lu and Yanli Chen and Xin Tao and Guangmin Zhou}, doi = {10.1002/anie.202507865}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507865}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An atmosphere-responsive protective strategy based on deciphering the anode degradation mechanism in Li–CO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Helical columnar liquid crystal exhibiting both polarization retention and ferroelectric switching at room temperature. ANGEW, 64(27), e202507574. (www)

  @article{ , abstract = {Ferroelectric columnar liquid crystals (FCLCs) with switchable bistable axial polarizations are promising candidates for high-density ferroelectric random-access memory (FeRAM). However, FCLCs simultaneously exhibiting uniform polarization arrangement and ferroelectric switching at room temperature (RT) remain elusive. Herein, we report an RT-operable FCLC based on C 3 -symmetric star-shaped mesogen with polar linkers. Two CLCs, 1 and 2 , were synthesized incorporating 1,2,3-triazole and amide linkers, respectively. 1 undergoes a ferroelectric-to-paraelectric transition accompanied by a structural change from helical to a nonhelical columnar phase. Notably, the ferroelectric switching is operable down to RT, with complete retention of its axial macrodipole after removal of the electric field. In contrast, 2 forms only a nonhelical columnar LC phase, displaying paraelectric behavior. The contrasting self-assembly and dielectric properties are attributed to the differences in the polar unit size. This study demonstrates that the mesogen extension with a bulky 1,2,3-triazole linker enables the realization of an FCLC operable at RT, offering significant potential for high-density FeRAM applications.}, archive = {J_ANGEW}, author = {Seongwon Park and Jaeduk Byun and Seong-hun Lee and Tae Joo Shin and Byoung-Ki Cho}, doi = {10.1002/anie.202507574}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507574}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Helical columnar liquid crystal exhibiting both polarization retention and ferroelectric switching at room temperature}, volume = {64}, year = {2025}, }
• (2025). Facile N═N bond cleavage of cis-azobenzene with bis-silylenes. ANGEW, 64(27), e202507560. (www)

  @article{ , abstract = {The very different features of cooperative disilicon(II)-mediated N═N bond activation of trans - vs. cis -azobenzene are reported, employing two bis-silylenes with distinct intramolecular Si···Si distances, PhN(LSi:)₂ 1 (L = PhC( t BuN)₂, Si···Si: 2.9 Å) and XT(LSi:)₂ 2 (XT = 9,9-dimethyl-xanthene-4,5-diyl, Si···Si: 4.3 Å). While trans -azobenzene reacts with both bis-silylenes to form C─H and N═N π bond activation products, the cis -isomer undergoes only N═N bond scission. Thus, the reaction of 1 with cis -azobenzene at room temperature affords the unprecedented N═N bond cleavage product 4 , featuring a bis-silaimine with terminal and bridging Si═N moieties. In contrast, the reaction of 2 with cis -azobenzene at –30 °C in THF allows for the isolation of the [1+2] cycloaddition intermediate 6 , containing a three-membered SiN₂ ring (siladiazirane), which rearranges to the N═N bond cleavage product 8 at room temperature. Compound 6 reacts with one additional equivalent of cis -azobenzene to form bis-silaazirane 7 with two SiN₂ rings. Density functional theory (DFT) calculations support stepwise Si(II)···Si(II) cooperative activation mechanisms and provide insights into the role of bis-silylenes for selective N═N cleavage reactions.}, archive = {J_ANGEW}, author = {Yun Xiong and Shenglai Yao and Matthias Driess}, doi = {10.1002/anie.202507560}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507560}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facile N═N bond cleavage of cis-azobenzene with bis-silylenes}, volume = {64}, year = {2025}, }
• (2025). Promoting alkane binding: Crystallization of a cationic Manganese(I)-pentane σ-complex from solution. ANGEW, 64(27), e202507494. (www)

  @article{ , abstract = {Transition metal–alkane σ -complexes are key intermediates in C–H activation and, until now, analysis of these species has been restricted to either the solution OR the solid state. Here we present a synthetic methodology that converts Mn 2 (CO) 10 in a noncoordinating solvent environment to [Mn(CO) 5 ] + at room temperature, and this species binds n -pentane as the strongest interacting ligand available. Three isomers of the n -pentane σ -complexes were studied in detail by solution NMR-spectroscopy at low temperature. Two isomers of [Mn(CO) 5 ( n -pentane)] + crystallize from solution at room temperature and their structures were determined by single crystal X-ray crystallography. The oxidation of metal complex dimers in solution to generate reactive metal cations, which bind alkanes as the strongest available ligand, is a new and probably general approach to generate metal-alkane σ -complexes.}, archive = {J_ANGEW}, author = {Malte Sellin and James D. Watson and Julia Fischer and Graham E. Ball and Leslie D. Field and Ingo Krossing}, doi = {10.1002/anie.202507494}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507494}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting alkane binding: Crystallization of a cationic Manganese(I)-pentane σ-complex from solution}, volume = {64}, year = {2025}, }
• (2025). Iron-doped cobalt molybdate enhanced electrochemiluminescence imaging for dynamic multilevel information encryption system construction and biomarker sensing analysis. ANGEW, 64(27), e202507426. (www)

  @article{ , abstract = {Integrating electrochemiluminescence (ECL) imaging with a multilevel information encryption strategy overcomes the limitations of conventional encryption methods, which rely solely on abstract electrical signals, by providing intuitive visual outputs. Herein, a dynamic multilevel information encryption system based on ECL imaging was successfully constructed, which realizes robust protection and precisely controlled decryption of information through the multidimensional security mechanism of “biometrics (biospecific recognition of the primary key) – electrochemical activation (precise voltage-triggered activation of the secondary key) – operational sequence dependence (strict matching of the operational timing)–signal gradient (decryptor judgment)”. Specifically, we develop a functional chemical ink comprised of iron-doped cobalt molybdate and biomolecules, which is applied onto nitrocellulose membranes via micro-patterned printing to construct biocompatible, environmentally responsive encryption interfaces. Density-functional theory calculations indicate that iron-doped cobalt molybdate accelerates the conversion of tripropylamine (TPrA) into TPrA radicals, forming a signal gradient with the cobalt molybdate catalytic region and thereby further enhancing the dimensionality of information encryption. Furthermore, a chemical ink-based ECL sensor was developed for ultra-sensitive detection of the cancer biomarker CA15-3, demonstrating the dual potential application in biomedical information security and disease diagnosis.}, archive = {J_ANGEW}, author = {Jingui Chen and Tingting Wu and Yu Du and Huaiqing Zhao and Dan Wu and Hongmin Ma and Zhong Feng Gao and Xiang Ren and Qin Wei}, doi = {10.1002/anie.202507426}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron-doped cobalt molybdate enhanced electrochemiluminescence imaging for dynamic multilevel information encryption system construction and biomarker sensing analysis}, volume = {64}, year = {2025}, }
• (2025). Electrochemically promoted activation of light alkanes at ambient conditions. ANGEW, 64(27), e202507417. (www)

  @article{ , abstract = {The electrochemical activation of light alkanes into value-added products represents a promising pathway for sustainable chemical synthesis and the storage of renewable energy. In this study, we introduce an electrochemically promoted system that employs copper plates as electrode and oxygen as oxidant, capable of converting ethane into ethylene and acetic acid with production rates of 6.9 and 6.2 µmol·cm −2 Cu ·h −1 , respectively, with a combined selectivity exceeding 92%, under ambient conditions. Additionally, this system can convert propane to propylene at a rate of 11.6 µmol·cm −2 Cu ·h −1 , with selectivity reaching up to 86%. A 10 h run with ethane demonstrates consistent production of ethylene and acetic acid, with a sustained selectivity above 96%, and achieves an acetic acid concentration of 19 mM. In situ spectroscopic analysis reveals the active surface and a critical reaction intermediate. Combining with partial pressure dependence study and density functional theory (DFT) calculations, we propose a potential reaction mechanism involving the competitive adsorption of oxygen and alkane producing an alkyl group as a key reaction step in the reaction process.}, archive = {J_ANGEW}, author = {Wenxuan Liu and Hsien-Chin Li and Chunsong Li and Wei-Sen Chen and Haochen Zhang and Bingjun Xu and Mu-Jeng Cheng and Qi Lu}, doi = {10.1002/anie.202507417}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507417}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemically promoted activation of light alkanes at ambient conditions}, volume = {64}, year = {2025}, }
• (2025). Metal-organic frameworks enable spontaneous singlet oxygen generation without light irradiation. ANGEW, 64(27), e202507349. (www)

  @article{ , abstract = {Singlet oxygen ( 1 O 2 ) is a widely used reactive oxygen species (ROS), making the development of new materials capable of efficiently generating it highly important. In this work, we report a series of isostructural metal-organic frameworks (MOFs), named JNU-300 (JNU = Jinan University), can spontaneously generate 1 O 2 by directly activating triplet oxygen ( 3 O 2 ) from the air without the need for additional light irradiation. The highly selective generation of 1 O 2 by JNU-300 is verified by electron paramagnetic resonance (EPR) spectroscopy and probe experiments for 1 O 2 . The generated 1 O 2 can be employed for aerobic oxidation of sulfide and antibacterial application. Mechanism studies revealed that the framework structure, and the adsorption and polarization of O 2 by the coordination units of JNU-300, are crucial for the 1 O 2 generation. To the best of our knowledge, MOFs JNU-300 are the first MOF material capable of producing 1 O 2 by activating 3 O 2 in the absence of light at room temperature. This work provides new insights into the design and construction of functional MOF materials capable of generating 1 O 2 via activating 3 O 2 without light irradiation, opening new possibilities for their application in specialized fields that require 1 O 2 in the dark.}, archive = {J_ANGEW}, author = {Hui-Ping Zhang and Qian Yi and Xin-Yu Guan and Rui-Rong Dai and Jie Pang and Qing Zhong and Shaozao Tan and Dong Luo and Yan Yan Li and Mo Xie and Xiao-Ping Zhou and Dan Li}, doi = {10.1002/anie.202507349}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507349}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-organic frameworks enable spontaneous singlet oxygen generation without light irradiation}, volume = {64}, year = {2025}, }
• (2025). Interfacial atom rearrangement drives potential-adaptive electrocatalytic olefin hydrogenation. ANGEW, 64(27), e202507269. (www)

  @article{ , abstract = {Dynamic rearrangement of metal atoms at heterointerfaces by chemical bond conversion drives high efficiency electrocatalytic processes, which is a new concept in the field of electrocatalysis and a new discovery to directly improve catalytic activity. It is of great significance to explore transformative catalytic systems that directly control the interfacial structure and function of atomic composition. As an emerging 2D carbon allotrope featuring unique sp - sp 2 co-hybridization, graphdiyne (GDY) offers unprecedented advantages for heterointerface engineering. In particular, the uneven surface charge distribution of GDY, high distribution of active sites and customizable electronic structures provide unprecedented opportunities for the development of a new generation of catalytic systems. Here, we report a new idea to directly control the cooperative growth and drive metal atomic rearrangement on the interface of GDY/NiPd/GDY. The results of atomic-resolution electron microscopy characterization revealed two unique interfacial phenomena: i) GDY-induced massive dislocation formation within NiPd nanoalloys and ii) rearrangement of surface metal atoms from (111) to (200) facets. Detailed spectroscopic analysis further demonstrated the composition-dependent evolution of elemental valence states and stoichiometric ratios. This atomic-level restructuring establishes a charge-redistribution network featuring non-integer charge transfer, which improves the overall conductivity and intrinsic activity. What is even more encouraging is that this electrocatalytic olefin hydrogenation is carried out in an aqueous solution. The GDY/NiPd/GDY heterostructure achieves exceptional activity (turnover frequency: 6.8 s −1 ), stability (>5 cycles), and chemo-selectivity (−100%), which is superior to traditional catalysts.}, archive = {J_ANGEW}, author = {Siao Chen and Yurui Xue and Yang Gao and Han Wu and Siyi Chen and Yunhao Zheng and Yuliang Li}, doi = {10.1002/anie.202507269}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial atom rearrangement drives potential-adaptive electrocatalytic olefin hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Metal complexes stimulating immunogenic pyroptosis as burgeoning antitumor strategy. ANGEW, 64(27), e202507186. (www)

  @article{ , abstract = {The exploration of antitumor agents with diverse action mechanisms has become an important focus in both fundamental research and clinical oncology, driven by the need for more effective cancer therapies. Metal complexes, with their versatile chemical, photophysical, and biological properties, represent an ideal class of therapeutic and diagnostic candidates for investigating novel antitumor mechanisms. Recent advances have underscored their unique ability to trigger diverse cell death pathways. Among these, pyroptosis, an inflammatory form of programmed cell death, has garnered substantial attention because of its intrinsic link to antitumor immunity. This minireview focuses on the cutting-edge developments in antitumor metal complexes designed to induce pyroptosis and elucidates their pyroptosis-stimulating mechanisms across chemo-, photo-, sono- and targeted therapeutic modalities. By dissecting the interplay among pyroptosis induction, biological processes, such as inflammasome activation and gasdermin cleavage, and subsequent immune reprogramming, we provide a thorough overview of the action mechanisms of metal complex-based pyroptosis inducers. This understanding has inspired the rational development of novel anticancer metal complexes that can remodel the tumor microenvironment and synergize with immunotherapies.}, archive = {J_ANGEW}, author = {Yue Zheng and Kun Peng and Qian Cao and Zong-Wan Mao}, doi = {10.1002/anie.202507186}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal complexes stimulating immunogenic pyroptosis as burgeoning antitumor strategy}, volume = {64}, year = {2025}, }
• (2025). Bridging the interlayer binding to ordered π-conjugated units for constructing high-performing light polarization crystals. ANGEW, 64(27), e202507171. (www)

  @article{ , abstract = {The light polarization modulation involves the capacity to respond selectively to light-mater interaction and is dependent on the optical anisotropy of crystalline materials. The π-conjugated component is almost typically utilized to produce such materials in the short-wave ultraviolet region; however, the conflicting link between high optical anisotropy and strong layered habit is difficult to reconcile. As a result, many anisotropic crystals are limited to tiny crystals rather than processing optical devices. This study designs crystals with beneficial but easy-to-grow layered structure and strong optical anisotropy by bridging the interlayer binding to ordered π-conjugated units. To this end, two new hybrid crystals Na 2 [C(NH 2 ) 3 ][HCOO] 3 (1Na) and K 2 [C(NH 2 ) 3 ][HCOO] 3 (2K) are reported by combining cationic regulation and π-conjugated units. The strong interlayer interaction and stable crystal structure of 1Na have been found to be caused by the orbital hybridization and Lewis acidity of Na + and [HCOO] groups. This allows for the easy growth of centimeter-large, high optical quality 1Na single crystals, providing crystal assurance for all-around testing for a practical crystal. Using the most accurate minimal deviation angle method, the birefringence is measured to be 0.174–0.258 @253-1013 nm, surpassing all reported crystals with the same components of [HCOO] or [C(NH 2 ) 3 ] in the applied short-wave ultraviolet region as well as the corresponding commercial crystals. More importantly, preliminary Glan–Taylor prism is designed to test its light polarization ability. This work will serve as a guide for future research on innovative short-wave ultraviolet birefringent crystals.}, archive = {J_ANGEW}, author = {Haotian Qiu and Ran An and Chen Cui and Zhi Li and Jinfeng Yang and Xiaochuang Wang and Xueling Hou and Junjie Li and Juanjuan Lu and Jun Sun and Zhihua Yang and Shilie Pan and Miriding Mutailipu}, doi = {10.1002/anie.202507171}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507171}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bridging the interlayer binding to ordered π-conjugated units for constructing high-performing light polarization crystals}, volume = {64}, year = {2025}, }
• (2025). Surface transformation in lanthanum nickelate for enhanced oxygen evolution catalysis. ANGEW, 64(27), e202507144. (www)

  @article{ , abstract = {Nickel-based perovskite oxides are identified as promising candidates for oxygen evolution reaction (OER) catalysts in view of their low cost, highly tunable structure, and potential high activity. However, the performance and catalyst design are hindered by their sluggish surface reconstruction kinetics. We introduce a ferric ion pre-etching strategy to enhance the surface reconstruction of typical LaNiO 3 . The hydrolysis of ferric ions generates hydrated protons that corrode the La-O terminal sites, inducing lattice distortion and lowering the energy barrier for reconstruction. Concurrently, ferric ion substitution for Ni creates crucial active sites after OER reconstruction, and enables the low-activity LaNiO 3 to become highly active and superior to the benchmark RuO 2 and NiFe layered double hydroxides (LDHs). In situ X-ray absorption spectroscopy (XAS) and in situ Raman spectroscopy reveal substantial surface transformation from corner-sharing to edge-sharing NiO 6 at 1.43 V versus reversible hydrogen electrode (RHE) in the surface pre-etched sample (LNFe III - spe ). This reconstruction is initiated by the lattice oxygen mechanism (LOM) and transitions to the adsorbate evolution mechanism (AEM), underscoring the transformation of distinct OER mechanisms.}, archive = {J_ANGEW}, author = {Jia Wei Zhao and Kaihang Yue and Lili Wu and Jiarui Yang and Deyan Luan and Xitian Zhang and Xiong Wen (David) Lou}, doi = {10.1002/anie.202507144}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface transformation in lanthanum nickelate for enhanced oxygen evolution catalysis}, volume = {64}, year = {2025}, }
• (2025). Generation, capture, storage, and release of singlet oxygen from a perylene diimide-based metallacage for oxygen sensing. ANGEW, 64(27), e202507112. (www)

  @article{ , abstract = {The controlled generation and utilization of singlet oxygen ( 1 O 2 ) are crucial for its diverse applications but remain challenging due to its high reactivity and short-lived nature. Here, we report a box-shaped metallacage prepared via multicomponent coordination-driven self-assembly using tetrapyridyl perylene diimide (PDI) and tetracarboxylate anthracene as building blocks. Upon photo-irradiation, the PDI faces act as photosensitizers to generate 1 O 2 , which reacts with the anthracene pillars to form a peroxidized metallacage, where 1 O 2 is captured and stored as anthracene peroxides. Heating releases 1 O 2 quantitatively, restoring the original metallacage structure. Both states are stable at room temperature, as confirmed by X-ray diffraction. Additionally, photoinduced electron transfer (PET) from anthracene pillars to PDI faces quenches the emission of the metallacage, while oxidation of anthracene inhibits PET, yielding bright fluorescence for the peroxidized metallacage. This reversible emission change enables the metallacage to function as a “turn-on” fluorescence sensor for dissolved oxygen, with a detection limit of 1.1 × 10 −3 mg L −1 . This study demonstrates a metallacage that can generate, capture, store, and release 1 O 2 for oxygen sensing, offering insights for designing stimuli-responsive smart materials.}, archive = {J_ANGEW}, author = {Yali Hou and Yingjie Li and Dengke Han and Zeyuan Zhang and Jinping Zhang and Shijin Jian and Zixuan Li and Xianglong Duan and Haonan Peng and Yu Fang and Mingming Zhang}, doi = {10.1002/anie.202507112}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Generation, capture, storage, and release of singlet oxygen from a perylene diimide-based metallacage for oxygen sensing}, volume = {64}, year = {2025}, }
• (2025). AI.zymes: A modular platform for evolutionary enzyme design. ANGEW, 64(27), e202507031. (www)

  @article{ , abstract = {The ability to create new-to-nature enzymes would substantially advance bioengineering, medicine, and the chemical industry. Despite recent breakthroughs in protein design and structure prediction, designing novel biocatalysts remains challenging. Here, we present AI.zymes, a modular platform integrating cutting-edge protein engineering algorithms within an evolutionary framework ( https://github.com/bunzela/AIzymes ). By combining bioengineering tools such as Rosetta, ESMFold, ProteinMPNN, and FieldTools in iterative rounds of design and selection, AI.zymes can optimize a broad range of catalytically relevant properties. In addition to enhancing transition state affinity and protein stability, AI.zymes can also improve properties that are not targeted by the employed design algorithms. For instance, AI.zymes can enhance electrostatic catalysis by iteratively selecting variants with stronger catalytic electric fields. Benchmarking AI.zymes on the promiscuous Kemp eliminase activity of ketosteroid isomerase led to a 7.7-fold activity increase after experimentally testing just 7 variants. Due to its modularity, AI.zymes can readily incorporate emerging design algorithms, paving the way for a unifying framework for enzyme design.}, archive = {J_ANGEW}, author = {Lucas P. Merlicek and Jannik Neumann and Abbie Lear and Vivian Degiorgi and Moor M. de Waal and Tudor-Stefan Cotet and Adrian J. Mulholland and H. Adrian Bunzel}, doi = {10.1002/anie.202507031}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202507031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {AI.zymes: A modular platform for evolutionary enzyme design}, volume = {64}, year = {2025}, }
• (2025). Topological control over porphyrin-based covalent organic frameworks for elucidating electron transfer characteristics. ANGEW, 64(27), e202506977. (www)

  @article{ , abstract = {Two-dimensional covalent organic frameworks (2D COFs) have emerged as promising functional materials due to their programmable architectures and tunable functionalities. Nevertheless, the structural diversity of porphyrin-based 2D COFs remains restricted by the prevalent use of sql topology, hindering comprehensive structure-property exploration. Herein, we systematically designed and synthesized porphyrinic 2D COFs featuring distinct sql and bex topological configurations. Comprehensive structural characterization confirmed precise control over lattice geometries, revealing monoporous structure in sql topology versus biporous architecture in bex topology. Electrochemical investigations uncovered topology-governed electron transport characteristics, with the unique coordination geometry of bex topology exhibiting enhanced electron transfer efficiency. Band structure analysis demonstrated that topological configuration and chemical composition collectively modulate electronic structures. Inspired by these findings, we developed nickel-incorporated bex -COFs for electrocatalytic oxygen evolution. The optimized Ni-BBFPP-TAPP-COF with bex topology demonstrated remarkable catalytic performance, achieving a low overpotential of 342 mV at 10 mA cm −2 , which surpasses most reported porphyrin-based electrocatalysts. This study not only significantly expands the structural repertoire of porphyrinic COFs but also establishes explicit correlations between topological engineering and electrocatalytic performance, providing fundamental design principles for advanced energy conversion materials.}, archive = {J_ANGEW}, author = {Kai Xu and Yaoqian Feng and Fuxiang Wen and Xiaoyi Xu and Hanwen Wang and Qing-Jun Shui and Ning Huang}, doi = {10.1002/anie.202506977}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506977}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topological control over porphyrin-based covalent organic frameworks for elucidating electron transfer characteristics}, volume = {64}, year = {2025}, }
• (2025). Control over S(VI)-stereogenic center: NHC-catalyzed enantioselective synthesis of N-acyl cyclic sulfonimidamides. ANGEW, 64(27), e202506929. (www)

  @article{ , abstract = {The catalytic enantioselective synthesis of aza-sulfur(VI) compounds holds significant potential in pharmaceuticals owing to their broad spectrum of biological properties. Herein, we report the first N-heterocyclic carbene (NHC)-catalyzed enantioselective synthesis of cyclic sulfonimidamides (SIAs). The free N–H containing SIAs often exhibit configurational lability through tautomerization. We investigated this by demonstrating their nonsymmetric nature in both solid state and solution. The in situ generated chiral acylazolium intermediates from easily accessible aldehydes in the presence of NHC and oxidant were trapped with the prochiral cyclic SIA anions, allowing the enantioselective synthesis of configurationally stable N -acyl cyclic SIAs. Mechanistic studies reveal that the present strategy proceeds via the desymmetrization of the prochiral SIA anions. Moreover, the derivatization of the synthesized N -acyl SIAs highlights the practical utility of the present methodology.}, archive = {J_ANGEW}, author = {Soumen Barik and Fathima Dinsha Paravakkal and Priyanshu Gupta and Palash Roy and Akkattu T. Biju}, doi = {10.1002/anie.202506929}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506929}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Control over S(VI)-stereogenic center: NHC-catalyzed enantioselective synthesis of N-acyl cyclic sulfonimidamides}, volume = {64}, year = {2025}, }
• (2025). The design of chemically self-charging aqueous batteries. ANGEW, 64(27), e202506922. (www)

  @article{ , abstract = {The chemically self-charging aqueous batteries are regarded as potential candidates for off-grid energy storage devices due to their environmental independence and simple construction. Although tremendous research efforts have been recently made to design chemically self-charging aqueous batteries, a comprehensive review about them is still absent. This review describes the design principles of chemically self-charging aqueous batteries and their self-charging mechanism. The advances in their cathode materials mainly include transition-metal oxides or sulfides, Prussian blue analogues, and organic compounds. Subsequently, the strategies of enhancing chemically self-charging kinetics are highlighted, including the design of materials, selection of oxidants, and the introduction of catalysts. In addition, various applications of chemically self-charging batteries are also discussed in wearable electronic devices, low temperatures, and all-pH scenarios. In the final section, the challenges and future perspectives are presented for designing high-performance chemically self-charging aqueous batteries. It will shed light on the R&D of chemically self-charging aqueous batteries.}, archive = {J_ANGEW}, author = {Huimin Wang and Buyu Ma and Jinlei Tian and Zhiqiang Niu}, doi = {10.1002/anie.202506922}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506922}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The design of chemically self-charging aqueous batteries}, volume = {64}, year = {2025}, }
• (2025). Development of chiral bisphosphine ligands with a terminal olefin enables asymmetric orthogonal auto-tandem catalysis. ANGEW, 64(27), e202506881. (www)

  @article{ , abstract = {Auto-tandem catalysis (ATC) leverages the multiple roles of the catalyst, facilitating the direct synthesis of complex molecules from simple starting materials in a highly efficient and step-economical manner. However, in conventional ATC, employing a single catalyst imposes significant limitations on the variety of catalyzed reactions. Herein, we present a novel catalysis strategy termed “orthogonal auto-tandem catalysis (OATC)”, which provides the unique opportunity to develop more efficient chemical transformations that cannot be achieved with existing catalytic modes. An unprecedented tandem annulation process involving four different catalytic cycles via asymmetric OATC is demonstrated. The enantio-determining step is a previously unrealized Pd(0)-catalyzed asymmetric allylic lactonization. The key to the whole success lies in the development of a new class of chiral bisphosphine ligands with a terminal olefin (TOPhos) that addressed not only the racemization issue of allylic ester products in classic π-allylmetal chemistry, but also the inherent compatibility challenges in transition-metal/organo dual catalytic system. Density functional theory (DFT) calculations unveil the vital role of the terminal olefin in TOPhos, enabling the differentiation of competitive enantioselective pathways.}, archive = {J_ANGEW}, author = {Dongyuan He and Hui Xu and Penglong Cao and Luqing Li and Youlian Luo and EI EI Mon and Fangzhi Peng and Long Li and Yanfeng Dang and Zhihui Shao}, doi = {10.1002/anie.202506881}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506881}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development of chiral bisphosphine ligands with a terminal olefin enables asymmetric orthogonal auto-tandem catalysis}, volume = {64}, year = {2025}, }
• (2025). Synthesis of nitriles from dinitrogen via N-atom transfer on rhenium nitride complex. ANGEW, 64(27), e202506857. (www)

  @article{ , abstract = {Transition-metal mediated dinitrogen (N 2 ) splitting into terminal nitrido moiety followed by N-atom transfer is an attractive strategy for N 2 fixation beyond ammonia. While the functionalization of N 2 -derived nitride complexes have been widely investigated, their N-atom transfer reactions to provide N-containing organic compounds were rarely reported. Herein, we report the synthesis of a rhenium nitride complex [( acri PNP)Re(N)Cl] ( acri PNP = 4,5-bis(diisopropylphosphino)-2,7,9,9-tetramethyl-9H-acridin-10-ide) via reductive N 2 cleavage from either rhenium trichloride or rhenium oxo dichloride complexes. The rhenium nitride exhibits N-atom transfer reactivity with acyl triflates or chlorides under mild conditions, affording nitriles concomitant with the regeneration of the nitride precursors, rhenium oxo or trichloride complexes, respectively. This overall N-atom transfer from N 2 to acyl electrophiles produced a series of alkyl, aryl, and heterocyclic nitriles, in moderate to good yields, offering a versatile and practical strategy for accessing 15 N-labeled nitriles. This work established a two-step synthetic cycle, offering valuable insights into transformations of N 2 into nitrogenous products.}, archive = {J_ANGEW}, author = {Chunxiao Shan and Yue Wu and Zhu-Bao Yin and Junnian Wei and Zhenfeng Xi}, doi = {10.1002/anie.202506857}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506857}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of nitriles from dinitrogen via N-atom transfer on rhenium nitride complex}, volume = {64}, year = {2025}, }
• (2025). Metal-organic cages assembled from {Ni6} nodes for selective CO2 reduction. ANGEW, 64(27), e202506838. (www)

  @article{ , abstract = {Constructing cluster-based nodes and using them as catalytic sites can bring new structure and function for metal-organic cages (MOCs). However, successful examples are very limited. Herein, we found that a 2-mercapto-5-methyl-1,3,4-thiadiazole (Hmmt) based {Ni 6 } subunit is robust in building such MOCs. The {Ni 6 } node is based on the central Ni 4 cubane and two wing Ni(II) ions with virtually three or four connected features. When various carboxylate ligands are incorporated the triangular prismatic [Ni 18 (Hmmt) 3 (mmt) 12 (BPDC) 6 (CH 3 O) 12 (H 2 O) 6 (DMF) 6 ] ( 4 /MOC-18N, H 2 BPDC = biphenyl-4,4′-dicarboxylic acid), tetrahedral-like [Ni 24 (Hmmt) 4 (mmt) 16 (BTC) 4 (CH 3 O) 16 Cl 4 (H 2 O) 4 (DMF) 5 (CH 3 OH) 3 ] ( 5 /MOC-24N, H 3 BTC = 1,3,5-benzenetricarboxylic acid) and the octahedral [Ni 36 (Hmmt) 6 (mmt) 24 (BTC) 8 (CH 3 O) 24 (H 2 O) 12 (DMF) 12 ] ( 6 /MOC-36N) can be isolated. Interestingly, MOCs 4–6 can uptake CO 2 in solid states. Moreover, they can effectively and selectively convert CO 2 into CO under visible light owing to the active wing Ni(II) ions, which are ancillarily coordinated with solvent molecules. All of them show turnover frequencies larger than 3500 µmol·g −1 ·h −1 and selectivity higher than 90%. This is a much higher performance compared to the usage of cage space for CO 2 reduction in previously reported MOCs and competitive to most Ni(II)-based simple coordination complexes. As such, this work may open a new paradigm for designing node based catalytic function for MOCs.}, archive = {J_ANGEW}, author = {Man-Ting Lv and Meng-Di Cui and Kai-Peng Bai and Yu Jiang and Wei-Peng Chen and Na-Na Sun and Xiang-Quan Hu and Chang Huang and Qing-Yuan Yang and Yan-Zhen Zheng}, doi = {10.1002/anie.202506838}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506838}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-organic cages assembled from {Ni6} nodes for selective CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Restricting two-electron oxygen reduction via secondary coordinated sulfur enabling ultralong-lifespan zn-air batteries. ANGEW, 64(27), e202506762. (www)

  @article{ , abstract = {The direct four-electron oxygen reduction reaction (4e − ORR) critically governs efficiency and lifespan in metal–air batteries and fuel cells, yet selectively suppressing competitive 2e − and stepwise 2e − pathways that generate corrosive hydrogen peroxide remains a major challenge. Herein, we demonstrate the strategic incorporation of secondary coordinated sulfur atoms into transition metal-N-C electrocatalysts to effectively promote direct 4e − ORR and simultaneously suppress undesirable 2e − pathways. Density functional theory (DFT) calculations and operando spectroscopy reveal that enhanced adsorption of key intermediate *OOH facilitates efficient O─O bond cleavage, underpinning altered catalytic selectivity. Importantly, this approach is universally applicable to various carbon-based catalysts, including Co─N@C, Ni─N@C, Mn─N@C, and N@C. Specifically, a sulfur-mediated Co─N/Co@C catalyst, comprising Co─N 4 sites and Co nanoparticles, dramatically lowers the 2e − O 2 -to-H 2 O 2 rate constant to merely 0.05-fold of its original value at 0.78 V. Consequently, Zn-air batteries using Co─N/Co@C-S as cathode exhibits an outstanding peak power density of 220 mW cm −2 , remarkable lifespan over 2500 h, and outstanding rate performance from 5 to 50 mA cm −2 . This work paves a generalizable route for designing highly active and selective electrocatalysts suitable for advanced long-life energy storage devices.}, archive = {J_ANGEW}, author = {Wenxian Liu and Jinxiu Feng and Henan Wang and Pu Wang and Dong Zheng and Wenhui Shi and Fangfang Wu and Tianqi Deng and Xiehong Cao}, doi = {10.1002/anie.202506762}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506762}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Restricting two-electron oxygen reduction via secondary coordinated sulfur enabling ultralong-lifespan zn-air batteries}, volume = {64}, year = {2025}, }
• (2025). Interface engineered electrolyte design strategy for ultralong-cycle solid-state lithium batteries over wide temperature range. ANGEW, 64(27), e202506731. (www)

  @article{ , abstract = {Achieving stable operation under a wide temperature range is the direction of development for the practical application of solid-state lithium batteries. However, the suboptimal ionic conductive properties exhibited by the electrolyte, the uncontrolled growth of lithium dendrites due to the deposition of inhomogeneous Li + and the potential safety hazards caused by unstable interfaces have seriously affected the cycle life of the battery at extreme temperatures. Herein, a fluoropolymer-containing plastic-crystal-based electrolyte (FPCE) has been developed by means of a structural engineering process, with the objective of optimizing the solid electrolyte interface (SEI). The integration of solvent structure simulation and experimental results demonstrates that FPCE regulates Li + transport, promotes the in-situ formation of the LiF-rich inorganic–organic hybrid SEI, and enhances the overall stability of the battery. Consequently, FPCE assists in preserving stable LFP|FPCE|Li cells cycling, with 5000 cycles at a high current density of 10 C and an average capacity decay rate of merely 0.00448% per cycle. Furthermore, the Ah-level pouch cells demonstrate the capacity to operate stably within the temperature range of −10 to 80 °C. This study provides a valuable strategy for the design of wide-temperature solid-state polymer electrolytes.}, archive = {J_ANGEW}, author = {Yunpeng Qu and Chang Su and Lin Wang and Borui Li and Wanyuan Jiang and Runyang Li and Mengfan Pei and Wenkai Song and Shuo Zhuo and Xin Jin and Dongming Liu and Xigao Jian and Fangyuan Hu}, doi = {10.1002/anie.202506731}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506731}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interface engineered electrolyte design strategy for ultralong-cycle solid-state lithium batteries over wide temperature range}, volume = {64}, year = {2025}, }
• (2025). Nonbonding electron inversion-driven structural engineering: Synergistic enhancement of linear and nonlinear optical properties. ANGEW, 64(27), e202506658. (www)

  @article{ , abstract = {The simultaneous optimization of large birefringence (Δn, a linear optical property) and strong second-harmonic generation (SHG, a nonlinear optical (NLO) property) in a single crystal remains a significant challenge due to the inherently distinct structural requirements for these properties. Although nonbonding electrons have been extensively studied in oxides and chalcogenides, research has predominantly focused on their role along polar axes, leaving their influence along axes in tetrahedral stacking largely unexplored. Herein, we propose a nonbonding electron-inversion strategy to overcome phase-matching limitations in defect diamond-like structures. By incorporating T2-[Ga 4 S 10 ] supertetrahedral motifs, we successfully synthesized [Ba 4 Cl 2 ][CdGa 4 S 10 ] (space group: I ), which exhibits a 219% enhancement in Δn compared to the nonphase-matching parent structure Cd 2 GaS 4 . The weakly bound nonbonding electrons, governed by atomic potentials, demonstrate strong SHG responses under optical fields. The compound [Ba 4 Cl 2 ][CdGa 4 S 10 ] not only achieves a broad transmission range (0.28–18.6 µm) and a high laser-induced damage threshold (40.1 × AgGaS 2 ) but also optimally balances a wide bandgap ( E g = 3.58 eV) and a large SHG response (1.4 × AgGaS 2 ), representing one of the best-performing Cd-based materials to date. This work introduces the first phase-matching design strategy based on nonbonding electron-driven structure–property relationships, providing critical insights for the rational design of high-performance NLO materials.}, archive = {J_ANGEW}, author = {Jia-Xiang Zhang and Sheng-Hua Zhou and Xin-Tao Wu and Hua Lin and Qi-Long Zhu}, doi = {10.1002/anie.202506658}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nonbonding electron inversion-driven structural engineering: Synergistic enhancement of linear and nonlinear optical properties}, volume = {64}, year = {2025}, }
• (2025). Understanding the position effects of monoatom doping in silver nanoclusters on oxygen reduction by single entity electrochemistry. ANGEW, 64(27), e202506627. (www)

  @article{ , abstract = {Alloying nanoclusters (NCs) with monoatom doping represents an effective strategy to enhance catalytic performances due to the synergistic interactions between the dopant and host atoms. However, in-depth understanding the position effects of monoatom doping within alloying NCs, particularly at the atomic level, remains elusive. Here, we employed single entity collision electrochemistry method to investigate the electrocatalytic behaviors of individual monoatom-doped bimetallic M 1 Ag 24 (M = Ag, Au, Pt, and Cu) NCs toward oxygen reduction reaction (ORR). By relying on high-resolution and high-throughput electrochemical measurements, we successfully discriminated the effects of monoatom variation in M 1 Ag 24 NCs on ORR activity at the single atom resolution and identified different M 1 Ag 24 NCs across characteristic populations. Our experimental findings and theoretical calculations reveal the electrocatalytic reaction dynamics associated with intracluster migration of Au monoatom during the dynamic alloying process of Au 1 Ag 24 NCs. This work demonstrates a novel approach for in situ identifying the position effects of foreign doping atoms on the electrocatalytic activity of alloy NCs at the single atom level.}, archive = {J_ANGEW}, author = {Zehui Sun and Cheng Chen and Mengdan Wei and Haifeng Wang and Jianfu Chen and Wei Ma}, doi = {10.1002/anie.202506627}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Understanding the position effects of monoatom doping in silver nanoclusters on oxygen reduction by single entity electrochemistry}, volume = {64}, year = {2025}, }
• (2025). Giant birefringence enabled by the highly anisotropic linear IX2− (X = cl, br) building blocks. ANGEW, 64(27), e202506625. (www)

  @article{ , abstract = {Birefringent crystals are essential for polarized optical devices, yet achieving large birefringence through rational design remains challenging. The key lies in constructing birefringence-active groups (BAGs) with giant polarization anisotropy and optimal spatial arrangements. Here, we report the successful construction of linear interhalogen BAGs, IX 2 − (X = Cl, Br), enabling giant polarization anisotropy. This was accomplished by simple halogenation of IO 3 − groups in an aqueous solution. Four novel birefringent crystals were synthesized: [H-4AP][ICl 2 ] ( 1 , 4AP = 4-aminopyridine), [HDMA] 2 [ICl 2 ]·Cl ( 2 , DMA = dimethylamine), [H-4AP][IBr 2 ] ( 3 ), and [HDMA] 2 [IBr 2 ]·Br ( 4 ). In all these compounds, the linear IX 2 − BAG adopts parallel arrangements, effectively maximizing synergistic polarization anisotropy. As a result, compounds 1 – 4 exhibit giant birefringence values in both the visible (0.647, 0.585, 0.836, and 0.782 at 546 nm) and near-infrared (NIR) regions (0.510, 0.356, 0.762, and 0.509 at 1064 nm), surpassing commercial birefringent crystals and many state-of-the-art materials. Furthermore, these compounds achieve an optimal balance between giant birefringence and moderate bandgap among linear BAG-based materials. Detailed theoretical calculations confirm that the IX 2 − BAGs play a dominant role in this exceptional birefringence. This study demonstrates the remarkable potential of linear interhalogen anions for developing high-performance birefringent crystals.}, archive = {J_ANGEW}, author = {Chong-An Chen and Yang Li and Hongbo Huang and Congcong Jin and Bingbing Zhang and Kang Min Ok}, doi = {10.1002/anie.202506625}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506625}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Giant birefringence enabled by the highly anisotropic linear IX2− (X = cl, br) building blocks}, volume = {64}, year = {2025}, }
• (2025). Boosting electronic charge transport in conductive hydrogels via rapid ion-electron transduction. ANGEW, 64(27), e202506560. (www)

  @article{ , abstract = {Traditional design of conductive hydrogels involves embedding conductive components within a hydrated polymeric network to establish interconnected electron pathways. While the hydration shell of the polymeric network is typically considered insulating, we demonstrate that it can enhance electron transport. Using a PEDOT:PSS hydrogel, we propose a hierarchical network with an inhomogeneous topological structure, consisting of entangled PSS chains, dense PSS assemblies, and PEDOT microcrystals. In the hydrated state, the dense PSS assemblies significantly lower the energy barrier for electron hopping between PEDOT microcrystals, thereby promoting electron transport. As a result, the charge transport mechanism in these hydrogels is predominantly electronic rather than ionic, effectively mimicking the behavior of electronic conductors. The charge transport rate reaches up to 2 × 10 6 m s −1 , which is approximately five orders of magnitude higher than that of ion-based processes. This characteristic imparts the hydrogels with kinetically sensitive ion-electron transduction, enabling time-resolved electrochemical analysis of biochemical processes.}, archive = {J_ANGEW}, author = {Zhou Li and Huiru Yun and Yuke Yan and Yang Zhao and Fei Zhao}, doi = {10.1002/anie.202506560}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506560}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting electronic charge transport in conductive hydrogels via rapid ion-electron transduction}, volume = {64}, year = {2025}, }
• (2025). Taxonomy of chemical bondings: Opportunities and challenges. ANGEW, 64(27), e202506525. (www)

  @article{ , abstract = {The concept of the chemical bond is fundamental to chemistry, governing atomic interactions that define all known matter. Despite this central role, the classification and most convenient naming of chemical bonds remain subjects of debate due to the diverse theoretical models and experimental observations. Modelings from quantum mechanical calculations and heuristic principles from experimental observations offer valuable and complementary insights, but sometimes the match and coalescence of these different approaches into a common terminology is not immediate. This paper describes a hierarchical categorization of noncovalent interactions based on the electrophilic atom involved, aligning with IUPAC definitions of hydrogen bonding (HB), halogen bonding (HaB), chalcogen bonding (ChB), and pnictogen bonding (PnB). The resulting taxonomy may avoid some ambiguities that arise from naming interactions based on single chemical/physical features. The proposed categorization that moves from more general and comprehensive terms to more specific and descriptive terms may ensure clarity, comprehensiveness, consistency with periodic trends, and invariancy over evolving understanding of the chemical bonds so that findings can be communicated and stored effectively via both human and machine based protocols.}, archive = {J_ANGEW}, author = {Andrea Pizzi and Giancarlo Terraneo and Cristina Lo Iacono and Roberta Beccaria and Arun Dhaka and Giuseppe Resnati}, doi = {10.1002/anie.202506525}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506525}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Taxonomy of chemical bondings: Opportunities and challenges}, volume = {64}, year = {2025}, }
• (2025). PH-responsive AIE photosensitizers for enhanced antibacterial therapy. ANGEW, 64(27), e202506505. (www)

  @article{ , abstract = {Bacterial infections significantly alter the local microenvironment, with acidic byproducts from bacterial metabolism leading to a pronounced pH reduction. Leveraging this characteristic, we synthesized and identified DHTPA, a near-infrared (NIR) fluorescent and pH-responsive aggregation-induced emission (AIE) photosensitizer, for enhanced photodynamic therapy against bacterial infections. DHTPA aggregates exhibit a 2.1-fold increase in ROS generation under weakly acidic conditions (pH 5.5) compared to neutral conditions (pH 7.4), attributed to its pH-dependent electronic structure modulation. Upon NIR light irradiation, DHTPA aggregates precisely respond to the acidic microenvironment, significantly boosting ROS production for efficient bacterial eradication. In vitro studies demonstrated that DHTPA achieved over 99.9% bactericidal efficiency against both gram-negative and gram-positive bacteria. In a murine infected wound model, DHTPA treatment accelerated wound healing by 2.4 times, markedly reduced bacterial burden, and alleviated inflammatory responses, highlighting its therapeutic potential. By integrating NIR activation, pH responsiveness, and AIE properties, DHTPA presents a precise and efficient antibacterial therapeutic strategy, offering an innovative solution for the clinical management of bacterial infections.}, archive = {J_ANGEW}, author = {Qihang Ding and Lina Ding and Chunbai Xiang and Chunbin Li and Eunji Kim and Changyu Yoon and Haoran Wang and Meijia Gu and Pengfei Zhang and Lin Wang and Ben Zhong Tang and Jong Seung Kim}, doi = {10.1002/anie.202506505}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506505}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PH-responsive AIE photosensitizers for enhanced antibacterial therapy}, volume = {64}, year = {2025}, }
• (2025). Nanoengineering carbon dot-polymer brush interfaces for adaptive optical materials. ANGEW, 64(27), e202506448. (www)

  @article{ , abstract = {We present a versatile platform for fabricating two-photon excitable carbon dot-based nanocomposite thin films by harnessing the structural versatility of polymer brushes in combination with electron-beam lithography (EBL). This approach enables the precise spatial organization of carbon dots (CDs) at the nanoscale, facilitating dynamic modulation of their photoluminescent properties in response to environmental stimuli. Three model systems were examined, incorporating pH- and thermally responsive polymers, functionalized through covalent and dynamic covalent bonding strategies. By leveraging the spatial control afforded by nanostructured polymer brushes, we achieved precise tuning of optical properties while mitigating aggregation-induced quenching, a longstanding challenge in solid-state CD applications. In addition to the advances in controlling optical properties, this work highlights the potential of polymer brush systems to function as optically active, reprogrammable surfaces. The resulting nanoscale-engineered materials exhibit highly responsive, reconfigurable photonic behavior, offering a scalable pathway for integrating advanced optical interfaces into microchip technologies, biosensing platforms, and multiplexed diagnostic systems. The fusion of polymer brushes, carbon dots, and advanced lithographic techniques marks a substantial advancement in the development of functional materials with nanoscale precision and stimuli-responsive properties.}, archive = {J_ANGEW}, author = {Gozde Aktas Eken and Nikolaos Chalmpes and Yuming Huang and Emmanuel P. Giannelis and Christopher Ober}, doi = {10.1002/anie.202506448}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506448}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanoengineering carbon dot-polymer brush interfaces for adaptive optical materials}, volume = {64}, year = {2025}, }
• (2025). Direct synthesis of Poly(adipate)Esters via catalytic isomerizing dual hydroesterificative polymerization of 1,3-butadiene. ANGEW, 64(27), e202506438. (www)

  @article{ , abstract = {Aliphatic polyesters, such as poly(adipate)esters, are attracting substantial attention as sustainable materials due to their degradability, recyclability, and versatility in various applications. However, the conventional production of poly(adipate)esters relies on energy-intensive processes and petroleum-derived adipic acid (AA), whose synthesis poses environmental concerns, including nitrous oxide emissions. Herein, we introduce a novel Pd-catalyzed isomerizing dual hydroesterificative polymerization (IDHP) strategy for direct poly(adipate)ester synthesis from readily available feedstocks of 1,3-butadiene, diols, and carbon monoxide. Key to success lay in the utilization of an electron-rich phosphine ligand with bulky steric hindrance, which efficiently facilitated linear-selective isomerizing hydroesterification. Mechanistic investigations revealed that the isomerizing hydroesterificative polymerization exhibited remarkable efficiency in producing poly(adipate)esters. The resulting poly(adipate)esters possess a similar structure compared to those produced by traditional polycondensation. With abundant feedstocks and atom-economy, this methodology provides a practical and eco-friendly approach to the production of poly(adipate)esters with varied microstructures.}, archive = {J_ANGEW}, author = {Shen Gao and Lei Su and Xuehe Lu and Huiwen Yang and Jiaming Zou and Xi Yang and Shan Tang and Jiawang Liu}, doi = {10.1002/anie.202506438}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506438}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct synthesis of Poly(adipate)Esters via catalytic isomerizing dual hydroesterificative polymerization of 1,3-butadiene}, volume = {64}, year = {2025}, }
• (2025). Lewis acid catalyzed divergent reaction of Bicyclo[1.1.0]Butanes with quinones for the synthesis of diverse polycyclic molecules. ANGEW, 64(27), e202506228. (www)

  @article{ , abstract = {Bicyclo[1.1.0]butanes (BCBs) are highly strained hydrocarbons with unique structural properties and intrinsic reactivity, making them valuable building blocks for constructing complex molecular architectures. Herein, we report the Lewis acid-catalyzed divergent reactions of BCBs with quinones, yielding a diverse array of polycyclic molecules. Using Sc(OTf)₃ as a catalyst, pyrazole-substituted BCBs efficiently undergo formal (3 + 2) cycloaddition reactions with quinones, producing highly substituted bicyclo[2.1.1]hexanes featuring a caged framework. Monosubstituted BCB ketones undergo a sequential cascade involving Alder-ene reaction, 4π electrocyclic ring-opening, and [4 + 2] cycloaddition reaction, yielding fused benzoxepines efficiently. Disubstituted BCB esters, ketones, and amides undergo a tandem isomerization and (3 + 2) cycloaddition process, stereoselectively yielding tetrahydrocyclobuta[b]benzofuran products. Notably, strong Lewis acids such as SnCl₄ and BiBr₃ directly participate in the ring-opening reactions of monosubstituted BCB ketones, generating halogenated cyclobutane derivatives. Additionally, the synthetic potential of these approaches has been further highlighted through scale-up experiments and a range of transformations. This study demonstrates the tunability of reaction pathways based on the diverse substitution patterns of BCBs, providing efficient methods for the synthesis of a range of polycyclic compounds.}, archive = {J_ANGEW}, author = {Qian-Qian Hu and Ze-Xiang Geng and Xue Bai and Jie Chen and Ling Zhou}, doi = {10.1002/anie.202506228}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506228}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lewis acid catalyzed divergent reaction of Bicyclo[1.1.0]Butanes with quinones for the synthesis of diverse polycyclic molecules}, volume = {64}, year = {2025}, }
• (2025). Ultrabright and water-stable Eu(III)-based MOF scintillators sensitized by dual-antenna ligands for real-time and underwater X-ray imaging. ANGEW, 64(27), e202506118. (www)

  @article{ , abstract = {Lanthanide-based metal–organic framework (Ln-MOF) scintillators are promising for X-ray imaging owing to their structural tunability and high X-ray attenuation. However, achieving efficient triplet-sensitized scintillation remains challenging due to the inefficient energy transfer between organic ligand triplets and lanthanide centers, leading to weak radioluminescence and limited imaging resolution. Herein, we propose a dual-antenna ligand strategy by synergizing 4,4′-oxybis (benzoic acid) (Oba) and phenanthroline derivatives (1,10-phenanthroline = Phen; or Bathophenanthroline = Bphen) with Eu 3+ ions, constructing ultrabright Eu-O-Phen and Eu-O-Bphen scintillators. Notably, Eu-O-Bphen demonstrated a record relative light yield of 60331 ±  28 photons MeV −1 , outperforming Eu-O-Phen by 71%. This superior scintillation performance originates from an 86.3 ± 0.19% photoluminescence quantum yield, attributed to enhanced ligand-to-metal energy transfer efficiency and the suppression of π–π stacking among organic chromophore ligands. Besides, the fabrication of flexible Eu-O-Bphen films achieves a spatial resolution of 37.0 lp mm −1 in static imaging and enables real-time dynamic X-ray imaging at 60 fps (2 K). Additionally, it exhibited exceptional water stability, with negligible performance degradation in water for over 100 days, allowing clear underwater visualization of circuit boards under X-ray irradiation. It provides a promising strategy for developing high-performance water-stable scintillators via ligand engineering.}, archive = {J_ANGEW}, author = {Hongming Chen and Xi Yang and Yuanji Ye and HongYang Hong and Qingsong Wei and Yanan Zhu and Mei-Jin Lin}, doi = {10.1002/anie.202506118}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506118}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrabright and water-stable Eu(III)-based MOF scintillators sensitized by dual-antenna ligands for real-time and underwater X-ray imaging}, volume = {64}, year = {2025}, }
• (2025). Tailored polymer-zeolite imidazolate framework membranes for aperture-matched c4 hydrocarbon separation. ANGEW, 64(27), e202506117. (www)

  @article{ , abstract = {The integration of metal-organic frameworks (MOFs) with polymers for efficient C4 hydrocarbon separation membranes remains challenging, primarily due to inherent phase incompatibility. This work presents an in-situ synthesis strategy for polymer-zeolitic-imidazolate frameworks (polyZIF), utilizing polymer-metal-ligand coordination bonds combined with structural directing agents to produce crystalline microporous frameworks. With an accessible BET surface area of 261 m 2 g −1 and a permanent porosity of ca. 4.42 Å, polyZIF membrane demonstrates butadiene permeance (∼332 GPU) and the selectivity over n -butene, n -butane, iso-butene, and iso-butane (17.2, 28.1, 21.5, and 34.8) under mixed gas conditions, respectively. Demonstrating practical scalability, the improved dispersibility and reduced interfacial defects in polyZIF facilitates fabrication of large-area defect-free membranes (up to 80 cm 2 ) while maintaining robust C4 separation performance. This advancement not only establishes a novel preparation for constructing polyZIF membranes with C4 hydrocarbon molecular-sieving capability but also provides critical insights into industrial application of ZIF-based polymer membranes.}, archive = {J_ANGEW}, author = {Ning Li and Chao Ma and Jingli Zhang and Lin Xu and Sa Wang and Ziyue Wang and Si Zhang and Jiandong Pang and Jingwei Hou and Zhihua Qiao and Chongli Zhong}, doi = {10.1002/anie.202506117}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506117}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailored polymer-zeolite imidazolate framework membranes for aperture-matched c4 hydrocarbon separation}, volume = {64}, year = {2025}, }
• (2025). Localized high-concentration electrolytes with semi-solvated hexafluoroisopropyl methyl ether diluent for wide-temperature-range lithium metal batteries. ANGEW, 64(27), e202506083. (www)

  @article{ , abstract = {Conventional electrolytes in lithium metal batteries (LMBs) suffer from irreversible interfacial degradation at elevated temperatures and sluggish Li⁺ desolvation/transport kinetics under cryogenic conditions. Herein, we present an innovative semi-solvated hexafluoroisopropyl methyl ether (HFME) diluent in localized high-concentration electrolytes (LHCEs) that strategically addresses these limitations. Li⁺ hopping networks within the electrolyte can be preserved even at low temperatures due to the coordination of lithiophilic groups in HFME molecules with Li⁺. Simultaneously, lithiophobic group induced spatial confinement effects promote the formation of anion–cation aggregates (AGGs), significantly optimizing Li⁺ desolvation kinetics and boosting the formation of inorganic-dominated solid electrolyte interphase (SEI) with exceptional thermal stability. Li||LiFePO 4 (LFP) cell with the diluent-coordinated LHCEs (DCL) can deliver 125.4 mA h g −1 initial capacity at −20 °C with 92.2% retention after 150 cycles. Under elevated temperatures (65 °C), the DCL-based Li||LFP cell can maintain the capacity retention of 91.3% over 60 cycles. The Li||NCM811 pouch cell (10 cm × 6.5 cm, capacity: 1000 mA h) based on the DCL exhibits outstanding cycling stability, retaining 91.6% of its initial capacity after 75 cycles. This work pioneers a solvent chemistry paradigm through spatially modulated solvation structures, establishing fundamental design principles for electrolyte for wide-temperature-range LMBs.}, archive = {J_ANGEW}, author = {Chuan Wang and Kai Wan and Pengfei Liu and Chenrui Zeng and Shuhan Wang and Yan Huang and Yang Zhang and Haoruo Xiao and Chaozhu Shu and Zhenxing Liang}, doi = {10.1002/anie.202506083}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506083}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Localized high-concentration electrolytes with semi-solvated hexafluoroisopropyl methyl ether diluent for wide-temperature-range lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Restoring Cell–Cell communication to elicit bystander effect using a DNA-based nanocomplex for robust immunotherapy. ANGEW, 64(27), e202506079. (www)

  @article{ , abstract = {The activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has shown promise in enhancing antitumor immunity. However, the pathway involved de novo transcription and translation processes, which delays immune responses. Besides, the rapid clearance of the secondary messenger cyclic GMP-AMP (cGAMP) by extracellular hydrolase limits its availability, attenuating STING signaling and resulting in insufficient therapeutic efficacy. Herein, we constructed a DNA-based nanocomplex, which could restore cell-cell communication to elicit bystander effect for enhancing cGAS-STING responses. By virtue of its capabilities to promote gap junctional intercellular communication for cGAMP transfer and to trigger immunogenic cell death (ICD) of tumor cells through bioorthogonal reaction-catalyzed drug synthesis, the cGAS-STING pathway in tumor cells was activated and amplified in a transcription-independent, horizontal manner. The nanocomplex presented safe and robust antitumor effects against not only primary tumors but also distant and metastatic tumors via abscopal effects. The work highlighted the effects of restoring cell–cell communication on cGAS-STING activation and provided a new perspective for antitumor immunotherapy.}, archive = {J_ANGEW}, author = {Yinuo Shu and Guoshi Xu and Minhao Jiang and Yanjie Zhang and Yinghua Peng and Jiawei Zhu and Weiguang Chen and Fang Pu and Jinsong Ren and Xiaogang Qu}, doi = {10.1002/anie.202506079}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506079}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Restoring Cell–Cell communication to elicit bystander effect using a DNA-based nanocomplex for robust immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Anchoring highly unsaturated Nickel(II) sites into a Metal–Organic framework for simultaneous high C2H2 adsorption and separation. ANGEW, 64(27), e202506055. (www)

  @article{ , abstract = {Separation of acetylene (C 2 H 2 ) from carbon dioxide (CO 2 ) remains a challenge to achieve both high C 2 H 2 uptake and selectivity for a single material. Porous materials with open metal sites (OMSs) have been widely employed to separate various gas mixtures; however, routine OMSs often show the limitation in C 2 H 2 /CO 2 separation due to the comparable binding affinity with the two gases. Herein, we report a new strategy of anchoring highly unsaturated nickel(II) sites into a large-pore MOF (Ni 2+ @NOTT-101-(COOH) 2 ) for simultaneously improving C 2 H 2 adsorption and selectivity. The coordination geometry of the anchored Ni 2+ ion was accurately determined by SCXRD studies, featuring a two-coordination model with highly unsaturated OMSs after the activation. This highly unsaturated Ni 2+ ion can provide additional binding sites to improve C 2 H 2 adsorption and also enable highly selective binding of C 2 H 2 over CO 2 through the specific and strong π- complexation interactions, as revealed by gas-loaded SCXRD studies and theoretical simulations. This metalated MOF thus exhibits both significantly enhanced C 2 H 2 uptake (201.4 cm 3 g −1 ) and C 2 H 2 /CO 2 selectivity (25.7) than the pristine NOTT-101-(COOH) 2 (148.0 cm 3 g −1 and 3.8) at 298 K and 1 bar, making an unprecedented balance between C 2 H 2 adsorption and selectivity to overcome the trade-off challenge. Breakthrough experiments on equimolar C 2 H 2 /CO 2 mixtures afford both the top-tier dynamic selectivity (14.4) and C 2 H 2 productivity of 114.5 L kg −1 (>99.5% purity) at ambient conditions.}, archive = {J_ANGEW}, author = {Yi-Zhan Hao and Hui-Min Wen and Yi-Hong Yu and Xu Zhang and Yuanjing Cui and Banglin Chen and Bin Li and Guodong Qian}, doi = {10.1002/anie.202506055}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506055}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anchoring highly unsaturated Nickel(II) sites into a Metal–Organic framework for simultaneous high C2H2 adsorption and separation}, volume = {64}, year = {2025}, }
• (2025). Enhancing waste plastic hydrogenolysis on Ru/CeO2 through concurrent incorporation of fe single atoms and FeOx nanoclusters. ANGEW, 64(27), e202506035. (www)

  @article{ , abstract = {Ru-based catalysts have exhibited significant promise in converting waste plastics into valuable long-carbon chain products. However, their efficiency is hindered by the uncontrollable cascade hydrogenation, which stems from their exceptional reactivity for C─C cleavage. Herein, we reported a multi-scale regulation strategy by selectively anchoring Fe single atoms (SAs) and FeO x nanoclusters (NCs) by Ru NCs-decorated CeO 2 substrates. This catalyst demonstrates an extraordinary performance, achieving nearly 100% low density polyethylene (LDPE) conversion under the conditions of 250 °C and 2 MPa hydrogen after 1 h, along with remarkably-improved liquid product selectivity of 86.4% compared to that of bare Ru/CeO 2 (59.8%). Through a variety of spectroscopic studies, we revealed the unique interactions between FeO x NCs and Ru NCs, which leads to an increased Ru° content. More significantly, we also confirmed the crucial role of Fe SAs in adsorbing active hydrogen species, thereby increasing the hydrogen coverage. Such precise regulations towards both the intrinsic surface state of Ru and its adjacent chemical environment successfully inhibited the cascade hydrogenation, ultimately resulting in a significant enhancement in the selectivity of liquid products.}, archive = {J_ANGEW}, author = {Xiaomei Wang and Rui Zhang and Xueting Wu and Yuou Li and Zijian Wang and Meng Zhao and Shuyan Song and Hongjie Zhang and Xiao Wang}, doi = {10.1002/anie.202506035}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506035}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing waste plastic hydrogenolysis on Ru/CeO2 through concurrent incorporation of fe single atoms and FeOx nanoclusters}, volume = {64}, year = {2025}, }
• (2025). Enhancing C─C bond cleavage of glycerol electrooxidation through spin-selective electron donation in Pd–PdS2–Cox heterostructural nanosheets. ANGEW, 64(27), e202506032. (www)

  @article{ , abstract = {As a 4 d transition metal, the spin state of Pd is extremely difficult to directly regulate for the optimized d orbital states owing to the strong spin-orbit coupling effect and further extended d orbital. Herein, we devise a “spin-selective electron donation” strategy to tune specific d orbital electrons of Pd inspired by the Dewar−Chatt−Duncanson model theory. Co−S−Pd bridges with different spin-states of Co III have been constructed in a series of Pd–PdS 2 –Co x HNSs with tunable Co content. Experiments and theoretical calculations indicate that low-spin Co III (t 2g 6 e g 0 ) with fully occupied t 2g orbitals and empty orbitals can accurately alter the electron of Pd by σ-donation via the Co−S−Pd bridge. In contrast, the unfilled d xy orbital of high-spin Co III (t 2g 5 e g 1 ) is essential for controlling the d xy electron of Pd via π-donation. Benefiting from state optimization by σ-donation, Pd–PdS 2 –Co 4.0 delivers superior performance toward various bio-alcohols (ethanol, ethylene glycol, and glycerol) with enhanced C─C bond cleavage. Furthermore, coupling the glycerol oxidation reaction with the CO 2 reduction reaction (GOR||CO 2 RR), the electricity consumption of GOR||CO 2 RR drops 46.4% compared to the state-of-art system (OER||CO 2 RR). Moreover, anodic Faraday efficiency (FE) of formic acid can be attainable at more than 90% at low voltage regions.}, archive = {J_ANGEW}, author = {Pei Liu and Hao Ma and Yuchen Qin and Junjun Li and Fengwang Li and Jinyu Ye and Qiudi Guo and Ning Su and Chao Gao and Lixia Xie and Xia Sheng and Shiju Zhao and Guangce Jiang and Yunlai Ren and Yuanmiao Sun and Zhicheng Zhang}, doi = {10.1002/anie.202506032}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202506032}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing C─C bond cleavage of glycerol electrooxidation through spin-selective electron donation in Pd–PdS2–Cox heterostructural nanosheets}, volume = {64}, year = {2025}, }
• (2025). Streamlining SuFEx inhibitor development: A unified approach using photolabile and orthogonal sulfinate protecting groups. ANGEW, 64(27), e202505984. (www)

  @article{ , abstract = {Sulfonyl fluorides (SFs) have gained significant importance due to their classification as a click reaction and therefore have seen increased use in drug discovery and biochemistry. Their use, however, is complicated by the methods by which they are synthesized and their general synthetic instability. This results in SFs being introduced late in a synthetic route with minimal structural diversity. Masking the reactivity of a sulfonyl fluoride by protecting the parent sulfinate is one method to ameliorate these issues. Current sulfinate protecting groups (SPGs), however, possess limited stability. This study outlines the discovery and selection of SPGs based on their overall stability, ease of synthesis, and simple deprotection conditions. This includes the discovery of two novel, photolabile SPGs, para -methoxybenzyl Rongalite and ortho -nitrobenzyl Rongalite that can be directly converted to the sulfonyl fluoride using light and selectfluor. Along with known SPG, 2-trimethylsilylethyl sulfone (SES), all three SPGs were found to possess broad stability when exposed to numerous common synthetic conditions and are easily coupled to aryl halides from their sulfinate salt precursor. Their utility is then demonstrated in the synthesis of SPG containing building blocks that are incorporated into several bioactive small molecules.}, archive = {J_ANGEW}, author = {Twinkle I. Patel and Makayla L. Williams and Yumeng Chi and Ramkrishna Laha and Matthew J. Moschitto}, doi = {10.1002/anie.202505984}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505984}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Streamlining SuFEx inhibitor development: A unified approach using photolabile and orthogonal sulfinate protecting groups}, volume = {64}, year = {2025}, }
• (2025). An update: Enzymatic synthesis for industrial applications. ANGEW, 64(27), e202505976. (www)

  @article{ , abstract = {Supported by rapid technological advancements, biocatalytic applications have matured into sustainable, scalable, and cost-competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme-based solutions for the manufacturing of molecules with extended carbon–carbon frameworks and multiple stereogenic centers at commercial scale, including peptide building blocks, (rare) sugars, synthetic (oligo)nucleotides, and terpenoids, such as (–)-Ambrox ® . Novel enzyme classes are highlighted along with their potential applications—the synthesis of DNA/RNA, the depolymerization of synthetic plastics, or fully enzymatic protection/deprotection schemes—pointing toward the diversification and broader industrial utilization of biocatalysis-based processes.}, archive = {J_ANGEW}, author = {Thomas Bayer and Shuke Wu and Radka Snajdrova and Kai Baldenius and Uwe T. Bornscheuer}, doi = {10.1002/anie.202505976}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505976}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An update: Enzymatic synthesis for industrial applications}, volume = {64}, year = {2025}, }
• (2025). P–p orbital hybridization stabilizing lattice oxygen in two-dimensional amorphous RuOx for efficient acidic oxygen evolution. ANGEW, 64(27), e202505908. (www)

  @article{ , abstract = {Developing efficient Ru-based catalysts is crucial in reducing reliance on costly Ir for the acidic oxygen evolution reaction (OER). However, these Ru-based catalysts face a fundamental stability challenge due to the highly reactive nature of lattice oxygen. In this work, we propose an effective strategy to stabilize lattice oxygen in 2D amorphous RuO x through p–p orbital hybridization by incorporating dopants such as Al, Ga, and In. Notably, Ga doping exhibits remarkable acidic OER performance, leading to a 137 mV reduction in overpotential at 10 mA cm −2 and a 125-fold improvement in stability compared to undoped RuO x . This also surpasses the performances of most reported Ru-based catalysts. In contrast, doping with other elements from the same period, such as Mn, Co, or Cu, shows negligible improvements in catalytic performance. In situ electrochemical spectroscopic analysis, couples with theoretical calculations, reveals that the p–p orbital hybridization in the Ga–O coordination within Ga–RuO x effectively reduces the reactivity of lattice oxygen, suppresses the overoxidation of Ru, and switches the reaction pathway from the lattice oxygen mechanism to the adsorbate evolution mechanism. This novel p–p orbital hybridization strategy holds great potential for the development of efficient and robust electrocatalysts for OER and beyond.}, archive = {J_ANGEW}, author = {Yajing Mu and Dantong Zhang and Tianyi Gao and Lina Wang and Lei Zhang and Xiaoxin Zou and Weitao Zheng and Jinchang Fan and Xiaoqiang Cui}, doi = {10.1002/anie.202505908}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505908}, shortjournal = {Angew. Chem. Int. Edit.}, title = {P–p orbital hybridization stabilizing lattice oxygen in two-dimensional amorphous RuOx for efficient acidic oxygen evolution}, volume = {64}, year = {2025}, }
• (2025). Structural basis for the catalytic mechanism of ATP-dependent diazotase CmaA6. ANGEW, 64(27), e202505851. (www)

  @article{ , abstract = {Although several diazotases have been recently reported, the details of the reaction mechanism are not yet understood. In this study, we investigated the mechanism of CmaA6, an ATP-dependent diazotase, which catalyzes the diazotization of 3-aminocoumaric acid using nitrous acid. X-ray crystallography and cryogenic electron microscopy-single particle analysis revealed CmaA6 structures in the substrate-free and AMP-binding states. Kinetic analysis suggested that CmaA6 catalyzes diazotization via a sequential reaction mechanism in which three substrates (nitrous acid, ATP, and 3-aminocoumaric acid) are simultaneously bound in the reaction pocket. The nitrous acid and 3-aminocoumaric acid binding sites were predicted based on the AMP-binding state and confirmed by site-directed mutagenesis. In addition, computational analysis revealed a tunnel for 3-aminocoumaric acid to enter the reaction pocket, which was advantageous for the sequential reaction mechanism. This study provides important insights into the catalytic mechanism of diazotization in natural product biosynthesis.}, archive = {J_ANGEW}, author = {Seiji Kawai and Masayuki Karasawa and Yoshitaka Moriwaki and Tohru Terada and Yohei Katsuyama and Yasuo Ohnishi}, doi = {10.1002/anie.202505851}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505851}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural basis for the catalytic mechanism of ATP-dependent diazotase CmaA6}, volume = {64}, year = {2025}, }
• (2025). Simultaneous improvement of mechanical strength, toughness, and self-healability of elastomers enabled by F─H-bond-based nanoconfinement. ANGEW, 64(27), e202505848. (www)

  @article{ , abstract = {There are often trade-offs among high mechanical strength, high toughness, and efficient self-healing. Herein, we present a biomimetic strategy utilizing F─H bonds for nanoconfinement to achieve the simultaneous enhancement of these conflicting properties. The mechanical strength, toughness, and self-healing efficiency of a fluorinated crosslinked poly(urethane-urea) (CPUU-FA) elastomer are improved 1.3-, 1.5-, and 1.2-fold, respectively, compared with those of its nonfluorinated counterpart. Notably, the CPUU-FA has the highest recorded puncture energy (887 mJ) among polymeric elastomers and the highest fracture energy (117 kJ m −2 ) among reported thermoset elastomers. Moreover, it exhibits excellent self-healing efficiency (99%), remarkable reprocessability, and a low surface energy (56 MJ m −2 ). The application of self-healing elastomers in the fabrication of soft electronics is further demonstrated. The molecular design strategy is anticipated to inspire new developments in high-performance materials for cutting-edge applications.}, archive = {J_ANGEW}, author = {Yujie Jia and Chengzhen Chu and Zekai Wu and Yufeng Ni and Shichun Cao and Tao Liao and Ce Shi and Yongfeng Men and Junfen Sun and Zhengwei You}, doi = {10.1002/anie.202505848}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505848}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous improvement of mechanical strength, toughness, and self-healability of elastomers enabled by F─H-bond-based nanoconfinement}, volume = {64}, year = {2025}, }
• (2025). Cooperativity of electron transfer coupled spin transitions in a tetranuclear Fe/Co prussian blue analogue revealed by ultrafast spectroscopy. ANGEW, 64(27), e202505813. (www)

  @article{ , abstract = {Cooperative intermolecular interactions, usually observed in solid state, can confer useful properties to stimuli–responsive spin transition materials. Here, we demonstrate for the first time intramolecular cooperativity between the two Fe–Co subunits of a molecular cyanido-bridged square Fe 2 Co 2 Prussian blue analogue (PBA) in solution, which upon single photon excitation sequentially undergo electron transfer coupled spin transition (ETCST) from a diamagnetic low-spin (LS) to a paramagnetic high-spin (HS) state. Ultrafast UV–vis and IR pump-probe spectroscopies show that irradiation into the IVCT band of the LS state induces electron transfer within one Fe–Co subunit followed by fast (360 fs) SCO to an intermediate HS/LS species and a further ETCST event in the other Fe–Co subunit then occurs on a ns timescale. Kinetic analysis reveals that this cooperative switching of the two Fe–Co subunits is caused by two coupled equilibria favouring the second ETCST step, and the free energy landscape for the square Fe 2 Co 2 system is determined experimentally.}, archive = {J_ANGEW}, author = {Jan-Hendrik Borter and Simindokht Gol Kar and Sayan Kangsa Banik and Serhiy Demeshko and Rainer Oswald and Martí Gimferrer and Ricardo A. Mata and Dirk Schwarzer and Franc Meyer}, doi = {10.1002/anie.202505813}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505813}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperativity of electron transfer coupled spin transitions in a tetranuclear Fe/Co prussian blue analogue revealed by ultrafast spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Metal-controlled enantiodivergent tandem rearrangement to synthesize 2H-azirines. ANGEW, 64(27), e202505725. (www)

  @article{ , abstract = {A metal-controlled enantiodivergent rearrangement of α-diazo-β-keto oxime ethers has been developed. Switching the metal catalyst from Co(II) to Fe(II) with an identical ligand completely reverses the asymmetric induction. Both enantiomers of chiral 2 H -azirines and its derivatives are accessible under thermal or photolytic conditions. The cobalt-based reaction is highly efficient even at 0.05 mol% catalyst loading. Mechanistic studies, including kinetic experiments and density functional theory calculations, reveal that distinct electronic properties of cobalt and iron modulate intermediate conformations, thereby altering the enantioselectivity.}, archive = {J_ANGEW}, author = {Zhendong Yang and Maoping Pu and Liangkun Yang and Yuqiao Zhou and Hongda Wu and Bosheng Wang and Xiaoming Feng and Xiaohua Liu}, doi = {10.1002/anie.202505725}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505725}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-controlled enantiodivergent tandem rearrangement to synthesize 2H-azirines}, volume = {64}, year = {2025}, }
• (2025). Hydrogen spillover-induced brønsted acidity enables controllable hydrocracking of polyolefin waste to liquid fuels. ANGEW, 64(27), e202505518. (www)

  @article{ , abstract = {Efficient upcycling of polyolefin waste into liquid fuels remains challenging due to over-cracking and the lack of sufficient acidity in non-zeolitic catalysts. Here, we report a Ni/niobium oxide nanorod (Ni/NbO x ) catalyst that achieves 95% selectivity to C 5–20 ​ alkanes at full polyethylene (PE) conversion under mild conditions (240 °C), with minimal gaseous products (4%). The catalyst reaches a high liquid fuel formation rate of 1274 g liquid ​ g Ni −1 ​ h −1 , rivaling noble metal systems. Its performance is governed by the morphology and crystallinity of NbO x nanorods, which provide sufficient acidity without micropore confinement, mitigating diffusion limitations and over-cracking. Detailed operando infrared spectroscopy and computational studies reveal, for the first time, that Brønsted acid sites, generated in situ via hydrogen spillover on the (110) facet, are the key catalytic sites in niobium oxide-based catalysts. The density of these acid sites exhibits a linear correlation with hydrocracking activity. The catalyst also demonstrates high efficiency across diverse polyolefin feedstocks and excellent reusability, offering a scalable and cost-effective solution for plastic upcycling.}, archive = {J_ANGEW}, author = {Xinlei Han and Yuchen Zhou and Shuangmei Chen and Huanhao Chen and Jiuxuan Zhang and Zhengyan Qu and Feng Zeng and Tuo Ji and Hong Jiang and Wei Cao and Zhenchen Tang and Rizhi Chen}, doi = {10.1002/anie.202505518}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505518}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen spillover-induced brønsted acidity enables controllable hydrocracking of polyolefin waste to liquid fuels}, volume = {64}, year = {2025}, }
• (2025). Synergistic ru species on poly(heptazine imide) enabling efficient photocatalytic CO2 reduction with H2O beyond 800 nm. ANGEW, 64(27), e202505453. (www)

  @article{ , abstract = {Photocatalytic CO 2 conversion with H 2 O to carbonaceous fuels is a desirable strategy for CO 2 management and solar utilization, yet its efficiency remains suboptimal. Herein, efficient and durable CO 2 photoreduction is realized over a Ru NPs /Ru-PHI catalyst assembled by anchoring Ru single atoms (SAs) and nanoparticles (NPs) onto poly(heptazine imide) (PHI) via the in-plane Ru-N 4 coordination and interfacial Ru-N bonds, respectively. This catalyst shows an unsurpassed CO production (32.8 µmol h −1 ), a record-high apparent quantum efficiency (0.26%) beyond 800 nm, and the formation of the valuable H 2 O 2 . Ru SAs tune PHI's electronic structure to promote in-plane charge transfer to Ru NPs, forming a built-in electron field at the interface, which directs electron-hole separation and rushes excited electron movement from Ru-PHI to Ru NPs. Simultaneously, Ru SAs introduce an impurity level in PHI to endow long-wavelength photoabsorption, while Ru NPs strengthen CO 2 adsorption/activation and expedite CO desorption. These effects of Ru species together effectively ensure CO 2 -to-CO conversion. The CO 2 reduction on the catalyst is revealed to follow the pathway CO 2 → *CO 2 → *COOH→ *CO→ CO, based on the intermediates identified by in situ diffuse reflectance infrared Fourier transform spectroscopy and further supported by density functional theory calculations.}, archive = {J_ANGEW}, author = {Bo Su and Sibo Wang and Wandong Xing and Kunlong Liu and Sung-Fu Hung and Xiong Chen and Yuanxing Fang and Guigang Zhang and Huabin Zhang and Xinchen Wang}, doi = {10.1002/anie.202505453}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505453}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic ru species on poly(heptazine imide) enabling efficient photocatalytic CO2 reduction with H2O beyond 800 nm}, volume = {64}, year = {2025}, }
• (2025). Modular access to aliphatic polycarbonates with tunable properties and dual closed-loop recyclability by Polycondensation–Depolymerization–Repolymerization strategy. ANGEW, 64(27), e202505333. (www)

  @article{ , abstract = {Great achievements have been made in CO 2 /epoxide copolymerization and dialkyl carbonate/diol polycondensation; however, efficient preparation of high-molecular-weight (>100 kDa) aliphatic polycarbonates with tunable properties and recyclability under mild conditions still remains as a great challenge. Herein, we presented a “polycondensation–depolymerization–repolymerization” strategy for structurally diverse aliphatic polycarbonates. This involved a step growth polycondensation of dialkyl carbonate and diol to low-molecular-weight (0.5−1.9 kDa) polycarbonates under atmosphere pressure, which are then utilized to produce cyclic carbonate monomers through catalytic depolymerization. The ring-opening polymerization of cyclic carbonate led to high molecular weight (>100 kDa) polymers, which can be converted back to cyclic monomer via ring-closing depolymerization or diol/dialkyl carbonate via alcoholysis, enabling chemical recycling of polycarbonates via dual closed loops. The thermal and mechanical properties of the polycarbonates can be widely adjusted by varying the substituent, and polycarbonate with four-membered spiro-cyclic substituent shows a recorded high melting temperature (217 °C) and mechanical strength within the reported polycarbonate family. A(hard)-B(soft)-A(hard) triblock thermoplastic elastomers with good mechanical performance and elastic recovery were also created by sequential polymerization. The “polycondensation−depolymerization−repolymerization” strategy provided a powerful toolbox for developing high-performance aliphatic polycarbonates.}, archive = {J_ANGEW}, author = {Wei-Ning Liu and Mingqian Wang and Zhiqiang Ding and Yuesheng Li and Bin Wang}, doi = {10.1002/anie.202505333}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505333}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular access to aliphatic polycarbonates with tunable properties and dual closed-loop recyclability by Polycondensation–Depolymerization–Repolymerization strategy}, volume = {64}, year = {2025}, }
• (2025). Rare earth single-atomic hybrid glasses for near-infrared II optical waveguides. ANGEW, 64(27), e202505322. (www)

  @article{ , abstract = {The increasing demands for modern information communication and storage necessitate the development of near-infrared (NIR) active optical waveguides. However, achieving efficient NIR emission with minimal optical loss remains a critical challenge. Herein, we present a new class of rare earth single-atomic hybrid glasses, synthesized via bottom-up self-assembly, as a solution to these limitations. By harnessing the ultralong phosphorescence of Nd 3+ -doped complex glasses, these materials achieve NIR-II emission extending to 1.32 µm with a photoluminescence quantum yield (PLQY) of ∼5.7%, setting a new record among state-of-the-art rare-earth-based complexes in the NIR-II region. This exceptional performance stems from the efficient sensitization of Nd 3+ ions in hybrid glass, with a phosphorescence energy transfer efficiency of 93.55%. Furthermore, these transparent and flexible hybrid glasses trigger optical waveguiding in Eu 3+ - and Nd 3+ -doped microstructures, enabling ultralow-loss coefficients of 0.978 dB mm −1 at 819 nm and 5.1 dB mm −1 at 1048 nm, respectively. Therefore, this work not only demonstrates that metal–organic complex glasses with ultralong phosphorescence can effectively serve as sensitizer matrices for boosting NIR-II emission, but also supports the fabrication of 1D and 2D glassy microstructures with ultralow-loss optical waveguiding for advanced NIR-II photonic applications.}, archive = {J_ANGEW}, author = {Meiqi Dai and Bo Zhou and Dongpeng Yan}, doi = {10.1002/anie.202505322}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505322}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rare earth single-atomic hybrid glasses for near-infrared II optical waveguides}, volume = {64}, year = {2025}, }
• (2025). Photodriven aquatic locomotion in liquid crystalline elastomer composites with tunable wettability. ANGEW, 64(27), e202505300. (www)

  @article{ , abstract = {Photodriven liquid crystalline elastomer (LCE) composites with thiol-functionalized Ti₃C₂T x MXene nanosheets are introduced as a versatile material system for achieving controlled aquatic locomotion. By incorporating superhydrophobic or superhydrophilic coatings, these composites demonstrate distinct modalities at the air–water interface and underwater. The stimuli-responsive behavior of the LCE nanocomposites is enhanced through the homogeneous dispersion of MXene platelets within the LCE matrix, facilitated by thiol-functionalization. Superhydrophobic coatings increase buoyancy and reduce drag, enabling locomotion akin to water striders at the air–water interface. Conversely, superhydrophilic coatings submerse the composites to allow photomechanical actuation to drive underwater locomotion against gravity. By combining tunable wettability with robust photothermal performance, these MXene-LCE composites open new opportunities for designing and integrating stimuli-responsive materials in aquatic actuation systems.}, archive = {J_ANGEW}, author = {Avijit Das and Joselle M. McCracken and Mohsin Hassan Saeed and Dhriti Nepal and Timothy J. White}, doi = {10.1002/anie.202505300}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505300}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photodriven aquatic locomotion in liquid crystalline elastomer composites with tunable wettability}, volume = {64}, year = {2025}, }
• (2025). Benzotrifuran-based covalent organic frameworks for artificial photosynthesis of H2O2 from H2O, o2, and sunlight. ANGEW, 64(27), e202505286. (www)

  @article{ , abstract = {Hydrogen peroxide (H 2 O 2 ) is an important green chemical and a potential energy carrier. Artificial photosynthesis of H 2 O 2 from only H 2 O and O 2 under sunlight is a fascinating and sustainable tactic. However, deficient proton sources come from the kinetically sluggish H 2 O oxidation process (∼s) seriously impede half-reaction of O 2 reduction (µs∼ms), leading to inferior photocatalytic efficiency. Herein, we prepare a benzotrifuran-based covalent organic framework featuring electron donor–acceptor character with hydrazone linkage. Spatially separated donor–acceptor π-stacking columns offer rich O 2 reduction and H 2 O oxidation active sites, also serve as channels for photoinduced charge separation and transport. Importantly, the 1D pore containing abundant heteroatoms facilitates H 2 O delivery to oxidation sites and reduces reaction energy barrier, thus improving the kinetic of H 2 O oxidation. Accordingly, this porous framework achieves efficient H 2 O 2 photocatalysis with an average mass rate of up to 9800 µmol g −1 h −1 from H 2 O and O 2 in the absence of any sacrificial reagent under simulated sunlight by balancing O 2 reduction and H 2 O oxidation reactions.}, archive = {J_ANGEW}, author = {Zhenwei Zhang and Yuxin Hou and Shanshan Zhu and Liuliu Yang and Yinghui Wang and Huijuan Yue and Hong Xia and Gang Wu and Shuo-wang Yang and Xiaoming Liu}, doi = {10.1002/anie.202505286}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505286}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Benzotrifuran-based covalent organic frameworks for artificial photosynthesis of H2O2 from H2O, o2, and sunlight}, volume = {64}, year = {2025}, }
• (2025). Triple synergy engineering via metal-free dual-atom incorporation for self-sustaining acidic ammonia electrosynthesis. ANGEW, 64(27), e202505211. (www)

  @article{ , abstract = {Electrochemical nitrate reduction reaction (NO 3 RR) for ammonia synthesis under acidic conditions offers significant advantages, like direct fertilizer production and prevention of ammonia volatilization. However, three critical challenges persist: instability of metal-based catalysts, competition from the hydrogen evolution reaction (HER), and proton depletion leading to species imbalance. Here, we developed a novel metal-free heteronuclear diatomic-based catalyst that simultaneously addresses these challenges through atomic-level triple synergy engineering. Silicon–iodine dual-atoms are precisely anchored on nickel oxide ultrathin nanosheets supported on carbon cloth (Si/I-NiO@CC) via a gradient-heating co-loading method. Si/I-NiO@CC establishes a self-sustaining catalytic system, achieving a remarkable Faradaic efficiency of 96.8% at −0.3 V versus RHE and record-breaking operational stability of 420 h in acidic electrolyte, surpassing the performance of all reported acid NO 3 RR electrocatalysts to date. Advanced in situ spectroscopic characterization combined with electrochemical evaluation reveals the triple synergy mechanism: electron-deficient Ni δ⁺ and oxygen vacancies generate abundant active sites while mitigating HER competition, iodine-mediated proton reservoirs dynamically regulate H* coverage to maintain species balance, and covalent Si─O─Ni interfacial bonding inhibits metal leaching and stabilizes the catalytic system. This work establishes a constructive guideline for the rational engineering of high-efficiency electrocatalysts for selective acidic NO 3 RR.}, archive = {J_ANGEW}, author = {Chuanzhen Feng and Kaiwen Bo and Jin Wan and Huijuan Zhang and Yu Wang}, doi = {10.1002/anie.202505211}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202505211}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triple synergy engineering via metal-free dual-atom incorporation for self-sustaining acidic ammonia electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Closo-carboranyl analogs of β-arylethylamines: Direct synthesis from alkenes via EnT-catalysis. ANGEW, 64(27), e202504793. (www)

  @article{ , abstract = {closo -Carboranes are icosahedral carbon–boron clusters with unique properties and broad applicability. They particularly stand out in the context of drug development as privileged structural motifs for boron neutron capture therapy (BNCT) and as highly hydrophobic bioisosteres for the rotational volume of phenyl rings. Herein, we unveil the synthesis of N-protected carboranyl analogs of β-arylethylamines—widely found structural motifs in biologically active molecules—via a one-step alkene difunctionalization approach. Key for our success were the enabling mechanistic characteristics of energy transfer catalysis which we have used for the first time to generate closo -carboranyl radicals. Downstream modifications gave a series of analogs of amino acids and known N -methyl- d -aspartate receptor (NMDAR) antagonists.}, archive = {J_ANGEW}, author = {Fritz Paulus and Corinna Heusel and Marc Jaspers and Lilli M. Amrehn and Florian Schreiner and Debanjan Rana and Constantin G. Daniliuc and Michael Ryan Hansen and Frank Glorius}, doi = {10.1002/anie.202504793}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504793}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Closo-carboranyl analogs of β-arylethylamines: Direct synthesis from alkenes via EnT-catalysis}, volume = {64}, year = {2025}, }
• (2025). Oscillatory strong metal-support interaction in Pd/TiO2 under redox conditions. ANGEW, 64(27), e202504686. (www)

  @article{ , abstract = {Strong metal-support interaction (SMSI) plays a crucial role in catalysis, with its encapsulation configuration being highly dependent on the chemical environments. However, the dynamic behavior of SMSI under redox conditions remains insufficiently understood. Here, environmental transmission electron microscopy (ETEM) revealed that SMSI overlayers form stably on the surface of Pd/TiO 2 nanocatalysts under pure O 2 and pure H 2 conditions, and exhibit oscillatory behavior under a redox condition with a 5:1 O 2 /H 2 ratio at 0.05 Pa. Specifically, the outer layer of the SMSI overlayer, characterized primarily by typical oxidative SMSI, undergoes oscillations between formation and retraction near the Pd-TiO 2 interface. The SMSI oscillations locally modify the morphology of the TiO 2 support, with the SMSI overlayer serving as a temporary reservoir for Ti species to drive the tip growth of the support protrusion. Our work expands the understanding of the dynamic behavior of SMSI under reaction conditions and provides new insights into the solid-state growth mechanism.}, archive = {J_ANGEW}, author = {Yuhui Chen and Jinting Hao and Kai Zhang and Songda Li and Zhongkang Han and Wentao Yuan and Ying Jiang and Ze Zhang and Yong Wang}, doi = {10.1002/anie.202504686}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504686}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oscillatory strong metal-support interaction in Pd/TiO2 under redox conditions}, volume = {64}, year = {2025}, }
• (2025). An artificial metal-free peroxidase designed using a ferritin cage for bioinspired catalysis. ANGEW, 64(27), e202504608. (www)

  @article{ , abstract = {Developing artificial enzymes is challenging because it requires precise design of active sites with well-arranged amino acid residues. Histidine-rich oligopeptides have been recently shown to exhibit peroxidase-mimetic activities, but their catalytic function relies on maintaining unique supramolecular structures. This work demonstrates the design of a specific array of histidine residues on the internal surface of the ferritin cage to function as an active center for catalysis. The crystal structures of the ferritin mutants revealed histidine–histidine interactions, forming well-defined histidine clusters (His-clusters). These mutants exhibit peroxidase-mimetic activities by oxidizing 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide. Molecular dynamics simulations further highlight the co-localization of TMB and hydrogen peroxide at the histidine-rich clusters, indicating that the confined environment of the ferritin cage enhances their interactions. This study presents a simple yet effective approach to design metal-free artificial enzymes, paving the way for innovations in bioinspired catalysis.}, archive = {J_ANGEW}, author = {Jiaxin Tian and Basudev Maity and Tadaomi Furuta and Tiezheng Pan and Takafumi Ueno}, doi = {10.1002/anie.202504608}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An artificial metal-free peroxidase designed using a ferritin cage for bioinspired catalysis}, volume = {64}, year = {2025}, }
• (2025). Nanochanneling and local crystallization engineering accelerate multiphase single-atom catalysis for rapid water decontamination. ANGEW, 64(27), e202504571. (www)

  @article{ , abstract = {Precise engineering of single-atom catalysts (SACs) with optimal hierarchical structures and favorable local chemical environments remains a significant challenge to cater for multiphase heterogeneous processes. Here, we develop a universal strategy for synthesizing channel-digging microspherical SACs that markedly enhance gas–liquid–solid mass transfer and fine-tune the thermodynamics of catalytic ozonation. By catalytically graphitizing carbon microspheres and selectively etching amorphous carbon domains via mild combustion, we fabricate cross-linked hierarchical graphitic nanochannels confining transition metal (e.g., Co, Cr, Mn, Fe, Ni) single atoms (TMCSs-Air). This nanoenvironment engineering increases interfacial ozone (O 3 ) mass transfer by 3.2-fold and directs O 3 adsorption from a conventional “end-on” to a bidental “side-on” configuration. The enhanced inter-orbital electronic interactions lower the O 3 activation barrier and form highly oxidizing surface-confined O 3 (*O 3 ). Consequently, the CoCSs-Air catalyst achieves a 3.6-fold higher ozone utilization efficiency and a 4.2-fold greater turnover frequency (TOF = 1580 min −1 ) compared with pristine Co-doped carbon microspheres (CoCSs). Technical and economic evaluations further confirm the feasibility of TMCSs-Air nanoreactors in treating real-world petrochemical wastewater, highlighting its broader potential in overcoming gas diffusion barriers and tuning reaction pathways for multiphase heterogeneous catalysis.}, archive = {J_ANGEW}, author = {Ya Liu and Yuxian Wang and Yunpeng Wang and Jie Miao and Jiajia Yang and Kunsheng Hu and Hongqi Sun and Jiadong Xiao and Chunmao Chen and Xiaoguang Duan and Shaobin Wang}, doi = {10.1002/anie.202504571}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanochanneling and local crystallization engineering accelerate multiphase single-atom catalysis for rapid water decontamination}, volume = {64}, year = {2025}, }
• (2025). Decoupled MOF breathing: Pressure-induced reversal of correlation between orthogonal motions in a diamondoid framework. ANGEW, 64(27), e202504297. (www)

  @article{ , abstract = {Responsive porous materials can outperform more rigid analogues in applications requiring precise triggering of molecular uptake/release, switching or gradual change in properties. We have uncovered an unprecedented dynamic response in the diamondoid MOF SHF-62 , (Me 2 NH 2 )[In(BDC-NHC(O)Me) 2 ] (BDC = 1,4-benzenedicarboxylate), by using pressure as a stimulus. SHF-62 exhibits two distinct framework “breathing” motions involving changes in 1) cross-section and 2) length of its 1D pores. Our study using synchrotron single-crystal X-ray diffraction in sapphire-capillary ( p < 0.15 GPa) and diamond-anvil (0.15 < p < 5 GPa) cells reveals that different pressure regimes trigger positive and negative correlation between these two motions, requiring an unprecedented mechanical decoupling. Specifically, the DMF-solvated framework SHF-62-DMF , in DMF as pressure-transmitting medium, undergoes initial hyperexpansion of pore cross-section ( p ≤ 0.9 GPa), due to DMF ingress, followed by reversal/reduction at p > 0.9 GPa while pore length contracts for all pressure increases, revealing decoupling of the two framework deformations. By contrast, nonpenetrating medium FC-70 imposes correlated compression ( p < 1.4 GPa) of pore cross-section and length, resembling framework activation/desolvation motions but of greater magnitude. Similar behavior occurs for SHF-62-CHCl 3 in CHCl 3 ( p < 0.14 GPa), suggesting minimal ingress of CHCl 3 . These findings change our understanding of MOF dynamic responses and provide a platform for future responsive materials development.}, archive = {J_ANGEW}, author = {David J. Ashworth and Elliot J. Carrington and Thomas M. Roseveare and Charles J. McMonagle and Martin R. Ward and Ashleigh J. Fletcher and Tina Düren and Mark R. Warren and Stephen A. Moggach and Iain D. H. Oswald and Lee Brammer}, doi = {10.1002/anie.202504297}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504297}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoupled MOF breathing: Pressure-induced reversal of correlation between orthogonal motions in a diamondoid framework}, volume = {64}, year = {2025}, }
• (2025). De novo design of structure-tunable multivalent targeting chimeras for tumor-targeted PD-l1 degradation and potentiated cancer immunotherapy. ANGEW, 64(27), e202504233. (www)

  @article{ , abstract = {Targeted protein degradation (TPD) technology holds significant potential for modulating protein homeostasis and treating diseases. However, current methods for degrading membrane proteins highly depend on the lysosome-targeting ligands or membrane receptors. In this study, we present a set of multivalent targeting chimeras (multi-TACs) for tumor-specific degradation of programmed death ligand 1 (PD-L1) on the surface of the tumor cell membrane. The multi-TACs are synthesized by copolymerization of small-molecule PD-L1 inhibitor BMS-1 with acid-responsive monomers. The chemical structures of the multi-TACs are optimized by investigating the correlation between PD-L1 degradation efficacy and the key parameters, including acid-sensitive moieties, BMS-1 valency, and spacer length. Mechanistic study reveals that the multi-TACs highly efficiently degrade PD-L1 on the surface of tumor cells via the adsorption-mediated endocytosis and lysosomal degradation pathways, which differ from the reported strategies for membrane protein degradation. The outperformed multi-TAC GG56 with tumor extracellular acidity and enzyme-sensitivity dramatically reduces PD-L1 levels and suppresses tumor growth in mouse models of B16-F10 melanoma and 4T1 breast tumors. Furthermore, GG56 serves as a versatile nanoplatform for combinatory chemo-immunotherapy and radio-immunotherapy of 4T1 breast tumor by co-delivery of chemotherapeutic and radio-sensitizer, respectively.}, archive = {J_ANGEW}, author = {Huiling Zhou and Bo Hou and Yiming Shan and Lujia Huang and Fangmin Chen and Siyuan Ren and Shunan Zhang and Jiaxing Pan and Yijing Dang and Haijun Yu and Zhiai Xu}, doi = {10.1002/anie.202504233}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504233}, shortjournal = {Angew. Chem. Int. Edit.}, title = {De novo design of structure-tunable multivalent targeting chimeras for tumor-targeted PD-l1 degradation and potentiated cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Phosphorescent Iridium(III) phenanthrolinedione complexes as lifetime-responsive bioorthogonal probes for wash-free time-resolved bioimaging of cellular labeling. ANGEW, 64(27), e202504230. (www)

  @article{ , abstract = {Fluorogenic bioorthogonal probes are crucial tools in biomedical research, which enable non-invasive, wash-free imaging of specific biomolecules in living systems. Lifetime-responsive bioorthogonal probes represent another promising and attractive alternative, offering the potential for real-time, wash-free visualization of bioorthogonal labeling processes via photoluminescence lifetime imaging microscopy (PLIM). However, their widespread application is limited by the lack of suitable lifetime-responsive probes. Herein, a series of phosphorescent iridium(III) phenanthrolinedione complexes were reported. Intriguingly, upon bioorthogonal reaction with an α-angelica lactone derivative, the complexes exhibited remarkable emission responses in three distinct manners, which were found to correlate with the different emissive excited states of the complexes. Crucially, two of the complexes maintained similar emission intensity but exhibited significant emission lifetime elongation during labeling reactions, which facilitated simultaneous and discriminative visualization of the reacted and unreacted probes in cellular imaging without the need for washing steps. One of the complexes was used for organelle targeting and specific protein labeling through bioorthogonal reactions in living cells. The intracellular probe transportation and labeling dynamics were visualized and analyzed using PLIM. This work highlights the unique potential of lifetime-responsive iridium(III) complexes as powerful chemical tools for live-cell imaging and unveiling the spatiotemporal dynamics of biomolecules during bioorthogonal reactions.}, archive = {J_ANGEW}, author = {Peiling Dai and Chenxiao Luo and Zhiqi Xu and Shuaishuai Sun and Yuyang Tian and Kenneth Yin Zhang and Kenneth Kam-Wing Lo and Shujuan Liu and Wei Huang and Huan Wang and Qiang Zhao}, doi = {10.1002/anie.202504230}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504230}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phosphorescent Iridium(III) phenanthrolinedione complexes as lifetime-responsive bioorthogonal probes for wash-free time-resolved bioimaging of cellular labeling}, volume = {64}, year = {2025}, }
• (2025). Cobalt-catalyzed asymmetric hydrogenation of α-hydroxy ketones enabled by a carboxylic acid additive promotion strategy. ANGEW, 64(27), e202504159. (www)

  @article{ , abstract = {Highly enantioselective hydrogenation of α-hydroxy ketones was achieved by applying the catalytic combination of cobalt acetate and chiral Ph-BPE ligand, supplemented by a carboxylic acid additive promotion strategy. The carboxylic acid additive significantly increases both reactivity and enantioselectivity, allowing for the highly efficient generation of chiral 1,2-diols with up to 99% ee. The application utility is proved through derivations and a total synthesis of ( R )-(−)-eliprodil. Mechanistic studies, including control experiments and DFT calculations, support the proposed catalytic mechanism and explain the origin of enantioselectivity.}, archive = {J_ANGEW}, author = {Yuxi Song and Yashi Zou and Tiantian Chen and Zhenfeng Zhang and Wanbin Zhang}, doi = {10.1002/anie.202504159}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504159}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-catalyzed asymmetric hydrogenation of α-hydroxy ketones enabled by a carboxylic acid additive promotion strategy}, volume = {64}, year = {2025}, }
• (2025). Nitrate reduction for deaminative Suzuki–Miyaura coupling of anilines. ANGEW, 64(27), e202504012. (www)

  @article{ , abstract = {We present a deaminative Suzuki–Miyaura-type coupling (SMC) of anilines with nitrate as a diazotization reagent, which integrates transition-metal catalysis with nitrate-based diazonium chemistry for the first time. The synergistic reduction of nitrate by bisulfite and boronic acids allows for both oxidative diazotization with low-valent transition metal redox transformations simultaneously. The reaction utilizes low-hazard, readily available starting materials and reagents. In comparison to previous diazonium-based Suzuki–Miyaura-couplings, the in situ oxidation of anilines by reduction of nitrate allows larger functional group tolerance.}, archive = {J_ANGEW}, author = {Chen-Chen Li and Áron Adorján and Manolis Sofiadis and Tim Schulte and Javier Mateos and Mike Rippegarten and Tobias Ritter}, doi = {10.1002/anie.202504012}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202504012}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitrate reduction for deaminative Suzuki–Miyaura coupling of anilines}, volume = {64}, year = {2025}, }
• (2025). Engineering bipolar covalent organic framework membranes for selective acid extraction. ANGEW, 64(27), e202503945. (www)

  @article{ , abstract = {Nitric acid (HNO 3 ) is a vital industrial chemical, and its recovery from complex waste streams is essential for sustainability and resource optimization. This study demonstrates the effectiveness of bipolar covalent organic framework (COF) membranes with tunable ionic site distributions as a solution for this challenge. The membranes are fabricated by layering anionic COF nanosheets on cationic COF layers, supported by a porous substrate. The resulting membranes exhibit significant rectifying behavior, driven by the asymmetric charge polarity and the intrinsic electric field, which enhances HNO 3 transport. The transmembrane diffusion coefficient of 2.74 × 10 −5 cm 2 s −1 exceeds the self-diffusion rate of NO 3 − , leading to increased HNO 3 flux and selectivity compared to the individual anionic and cationic COF membranes. The optimized bipolar membrane configuration achieves remarkable separation factors, ranging from 22 to 242,000 for HNO₃, in comparison to other solutes such as HCl, H 2 SO 4 , H 3 PO 4 , and various metal salts in an eight-component mixed waste stream. This results in a substantial increase in HNO₃ purity, from 12.5% to 94.1% after a single membrane separation. With the broad range of COF materials and the versatility of the proposed membrane design, this work represents a significant advancement in chemical separation technologies.}, archive = {J_ANGEW}, author = {Di Wu and Zhiwei Xing and Qing Guo and Zhuozhi Lai and Jiaming Yi and Qing-Wei Meng and Sai Wang and Zhifeng Dai and Shengqian Ma and Qi Sun}, doi = {10.1002/anie.202503945}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503945}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering bipolar covalent organic framework membranes for selective acid extraction}, volume = {64}, year = {2025}, }
• (2025). Metathetical exchange, synthesis, and carbon dioxide addition of higher homologues of group 9 metal carbynes. ANGEW, 64(27), e202503930. (www)

  @article{ , abstract = {A one-pot synthesis for previously unknown heavy homologues of Group 9 metal carbynes [(Me 3 P) 3 Co≡GeAr*] ( 1 ), [(Me 3 P) 3 Rh≡GeAr*] ( 2 ), [(Me 3 P) 3 Ir≡GeAr*] ( 3 ), [(Me 3 P) 3 Ir≡SnAr*] ( 5 ), and [(Et 3 P) 3 Ir≡PbAr*] ( 7 ) is presented [Ar* = C 6 H 3 -2,6-(Trip) 2 , Trip = 2,4,6-C 6 H 2 i Pr 3 ]. During these preparations, the tetrylidynes [(Me 3 P) 3 Rh≡SnAr*] ( 4 ), and [(Me 3 P) 3 Rh≡PbAr*] ( 6 ), were also prepared in a one-pot procedure. In a hitherto unknown metathetical exchange reaction, the transition metal plumbylidynes were converted into the respective stannylidynes in reaction with terphenyl stannylene chloride, and the germylidynes were formed from the corresponding stannylidynes in reaction with terphenyl germylene chloride. These metathesis reactions were tracked by 31 P{ 1 H} NMR spectroscopy, which shows complete exchange of the tetrel [EAr]-fragment and the formation of an intermediate in the rhodium plumbylidyne reaction with stannylene chloride (Ar = Ar*, Tbb). Reactions of the tetrylidynes ( 2 – 5 ) with carbon dioxide yield the products of a redox reaction [(Me 3 P) 3 (CO)M-E( η 2 -O 2 CO- κ 2 O )Ar*] [E = Ge, M = Rh ( 11 ); M = Ir ( 12 ); E = Sn, M = Rh ( 14 ), M = Ir ( 16 )] with a carbon monoxide coordinated at the transition metal and a carbonate coordinated at the Group 14 element. For tin the intermediates formed by mono CO 2 addition [(Me 3 P) 3 M( μ , η 2 -CO 2 - κC : κO )SnAr*] [M = Rh ( 13 ), M = Ir ( 15 )] have been isolated.}, archive = {J_ANGEW}, author = {Lennart G. Holzapfel and Johanna Manegold and Stefan F. Clewing and Hartmut Schubert and Klaus Eichele and Lars Wesemann}, doi = {10.1002/anie.202503930}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503930}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metathetical exchange, synthesis, and carbon dioxide addition of higher homologues of group 9 metal carbynes}, volume = {64}, year = {2025}, }
• (2025). Lattice water deprotonation enables potassium-ion chemistries. ANGEW, 64(27), e202503904. (www)

  @article{ , abstract = {Electrochemical water splitting is a key process in clean energy applications and usually occurs on the surface of catalytic materials. Here, we report the anomalous partial water splitting, namely, water deprotonation behavior within the lattice of hydrated materials modeled by Fe 1- x Mg x (C 2 O 4 ) • 2H 2 O ( x ≈ 0.25–0.43), which triggers the otherwise inactive framework into an excellent cathode material for potassium ion storage. Density functional theory suggests that redox-active lattice Fe sites can split crystal water into hydroxyls and hydrogens in the initial charge, rendering thereafter reversible K-ion chemistries, whereas lattice Mg sites are inactive but stabilize the entire framework. Our experiments validated the as-predicted electrochemical behavior, and the isotopic tracing unambiguously confirmed the hydrogen evolution from crystal water. This intriguing “water deprotonation in lattice” phenomenon may open a new path for the design of cathode materials by electrolysis-assisted electrochemistry.}, archive = {J_ANGEW}, author = {Huan Xu and Nanzhong Wu and Bifa Ji and Jinghua Cai and Wenjiao Yao and Zihang Wang and Yatian Zhang and Xinyuan Zhang and Shu Guo and Xiaolong Zhou and Pinit Kidkhunthod and Yongping Zheng and Yongbing Tang}, doi = {10.1002/anie.202503904}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503904}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lattice water deprotonation enables potassium-ion chemistries}, volume = {64}, year = {2025}, }
• (2025). Hyperpolarization modulation of the T-type hCav3.2 channel by human synenkephalin [1–53], a shrew neurotoxin analogue without paralytic effects. ANGEW, 64(27), e202503891. (www)

  @article{ , abstract = {Mammalian secreted venoms mainly consist of peptides and proteases used for defense or predation. Blarina paralytic peptides (BPPs), mealworm-targeting neurotoxins from shrew, are very similar to human synenkephalin. This peptide is released from proenkephalin in the brain along with opioid peptides that mediate analgesic and antidepressant effects, though its physiological function is unclear. Here, we synthesized and characterized human synenkephalin [1–53] (hSYN) and reveal its disulfide bond connectivity. Similar to BPP2, hSYN caused a hyperpolarizing shift in the human T-type voltage-gated calcium channel (hCa v 3.2) at 0.74 µM, but did not paralyze mealworms. Molecular docking and molecular dynamics simulations showed that hSYN and BPP2 interact with hCa v 3.2 channel differently, due to differences in polar residues. Since Ca v 3.2 channel regulates neuronal excitability and is implicated in conditions like autism and epilepsy, our findings on hSYN could provide insight into the channel gating and agonistic mechanisms, along with potential pathways for developing treatments for neurological disorders.}, archive = {J_ANGEW}, author = {Ryo Fukuoka and Yusuke Yano and Nozomi Hara and Chihiro Sadamoto and Andres D. Maturana and Masaki Kita}, doi = {10.1002/anie.202503891}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503891}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hyperpolarization modulation of the T-type hCav3.2 channel by human synenkephalin [1–53], a shrew neurotoxin analogue without paralytic effects}, volume = {64}, year = {2025}, }
• (2025). Synergistic effect of boron and oxygen coordination on ruthenium clusters for industrial water splitting in alkaline medium. ANGEW, 64(27), e202503871. (www)

  @article{ , abstract = {The alteration in the coordination environment of metal atoms can manipulate their electronic structure and regulate the electrocatalytic hydrogen evolution activity. In this work, synchrotron radiation tests prove that the boron (B) and oxygen (O) elements co-coordinate with ruthenium clusters (Ru C ) on the surface of B–O modified reduced graphene oxide. The electrochemical tests demonstrate that this unique structure electrocatalyst presents an overpotential of 12 mV in 1 M KOH condition and for over 120 h at the current of −1 A cm −2 , indicating potential practical applications. The quasi in-situ X-ray photoelectron spectroscopy and in-situ infrared spectroscopy confirmed that the B–O diatomic coordination can modulate the synergy between the substrate and the Ru C catalytic site, enhancing the intrinsic catalytic activity and ion migration efficiency. The first principles calculation further proves that B–O diatomic coordination will reduce the desorption barrier of H* and construct a complete hydrogen migration path. This study discloses the significance of the synergistic effect of two anions to enhance the catalytic activity of the catalyst by altering the coordination environment of ruthenium clusters.}, archive = {J_ANGEW}, author = {Huxu Lei and Weiwei Yang and Shengnan Hu and Luocai Yi and Chuanming Ma and Chengsi Hu and Fangren Qian and Ming Zhao and Lie Liu and Guangzhi Yang and Qingjun Chen}, doi = {10.1002/anie.202503871}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503871}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic effect of boron and oxygen coordination on ruthenium clusters for industrial water splitting in alkaline medium}, volume = {64}, year = {2025}, }
• (2025). Bayesian meta-learning for few-shot reaction outcome prediction of asymmetric hydrogenation of olefins. ANGEW, 64(27), e202503821. (www)

  @article{ , abstract = {Recent years have witnessed the increasing application of machine learning (ML) in chemical reaction development. These ML methods, in general, require huge training set examples. The published literature has large amounts of data, but there are modelling challenges due to the sparse nature of these datasets. Herein, we report a meta-learning workflow that can utilize the literature-mined data and return accurate predictions with limited data. A literature dataset comprising of over 12 000 transition metal catalyzed asymmetric hydrogenation of olefins (AHO) is chosen to demonstrate the utility of our protocol. A meta-model is trained in a binary classification setting to identify highly enantioselective AHO reactions. Two Bayesian meta-learning approaches are considered, namely, deep kernel transfer (DKT) and adaptive deep kernel fitting (ADKF). Both these methods returned better predictions compared to prototypical network, which is another popular meta-learning approach. Single-task methods, such as random forest, graph neural network, and deep kernel learning, performed worse than meta-learning methods even when trained on full training data. Additionally, we propose another meta-learning approach called ADKF-prior that is shown to further improve the performance in low-data settings. The generalizability of our meta-model is also evaluated on substrate- and time-based splits. Our meta-learning workflow can be utilized to build a pretrained meta-model for any reaction of interest, which can then be useful to predict the outcome of new but related reactions in a few-shot manners.}, archive = {J_ANGEW}, author = {Sukriti Singh and José Miguel Hernández-Lobato}, doi = {10.1002/anie.202503821}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503821}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bayesian meta-learning for few-shot reaction outcome prediction of asymmetric hydrogenation of olefins}, volume = {64}, year = {2025}, }
• (2025). A carboxylate-based hydrophilic organic photovoltaic catalyst with a large molecular dipole moment for high-performance photocatalytic hydrogen evolution. ANGEW, 64(27), e202503792. (www)

  @article{ , abstract = {Achieving ultrafast dissociation of photogenerated excitons and efficient charge transport within the photocatalyst is a fundamental issue. Additionally, enhancing the interaction between semiconductors and water is crucial for efficient photocatalytic water splitting. Herein, we synthesized a carboxylate-based hydrophilic polymer, hPTB7-Th. Exposed carboxylates enhance semiconductor-water interfacial compatibility, reducing contact resistance and accelerating charge transfer kinetics. Furthermore, the carboxylate substitution shifts polarity centers, amplifying the molecular dipole moment by 10-fold. This induces a giant built-in electric field, enabling ultrafast electron-transfer process (ca. 0.31 ps) in the hPTB7-Th:PCBM bulk heterojunction. Consequently, the hPTB7-Th:PCBM-based bulk heterojunction nanoparticles exhibit excellent photocatalytic activity, achieving an optimal hydrogen evolution rate of 111.5 mmol g −1 h −1 , four times over the ester-based counterpart (PTB7-Th:PCBM). Moreover, the electrostatic stability imparted by the carboxylates endows hPTB7-Th:PCBM with outstanding operational stability, maintaining 81% of its initial hydrogen evolution rate after 100 h operation. This result places it among the state-of-the-art organic photovoltaic bulk heterojunction photocatalysts in terms of stability. This work establishes a molecular engineering strategy for high-performance bulk heterojunction photocatalysts, emphasizing synergistic optimization of hydrophilicity, dipole engineering, and interfacial dynamics.}, archive = {J_ANGEW}, author = {Hua Sun and Jianan Fan and Rong Fan and Po Sun and Shifan Wang and Danfeng Wang and Peiyang Gu and Wenyi Tan and Yongfa Zhu}, doi = {10.1002/anie.202503792}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503792}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A carboxylate-based hydrophilic organic photovoltaic catalyst with a large molecular dipole moment for high-performance photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). In situ “Confocal” electrochemiluminescence 3D imaging: From cell to tissue section. ANGEW, 64(27), e202503594. (www)

  @article{ , abstract = {Endowing electrochemiluminescence (ECL) imaging technique with three-dimensional (3D) resolution to investigate specimens at varying axial depths poses a challenging yet significant objective. Herein, a “confocal” 3D ECL imaging method was developed using luminol as ECL probe, in which excited luminophore was formed in the vicinity of electrode surface through homogeneous chemical reactions between oppositely diffusing ECL precursors, luminol diazaquinone intermediate (L), and hydrogen peroxide (H 2 O 2 ), confining the ECL emission in a thin plane (ECL focal plane) parallel to electrode surface at their intersection. The regulating ability of electrochemical method on the reaction fluxes of L and H 2 O 2 was validated, regulating the axial location of the ECL focal plane from 0 to 63 µm, which can even extend to 400 µm by using the stable coreactant of ClO − . Leveraging the optical sectioning capability of the ECL focal plane, the “confocal” 3D ECL imaging method was applied to bioimaging, from cells to tissue sections. It revealed cellular morphology changes during cell polarity establishment and the heterogeneous distribution of complex tubule structure in kidney tissue sections. The optical sectioning capability of “confocal” 3D ECL imaging makes it a powerful tool for studying complex biological samples.}, archive = {J_ANGEW}, author = {Hongye Wang and Shiyu Zhang and Shengrui Xia and Juanhua Zhou and Yang Liu}, doi = {10.1002/anie.202503594}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503594}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ “Confocal” electrochemiluminescence 3D imaging: From cell to tissue section}, volume = {64}, year = {2025}, }
• (2025). Harnessing lithium-mediated green ammonia synthesis with water electrolysis boosted by membrane electrolyzer with polyoxometalate proton shuttles. ANGEW, 64(27), e202503465. (www)

  @article{ , abstract = {Integrating water electrolysis (WE) with lithium-mediated nitrogen reduction (Li-NRR) offers a sustainable route for green ammonia production by directly utilizing protons from water oxidation, eliminating reliance on grey or blue hydrogen. Here, polyoxometalates (POMs) function as electron-coupled proton buffers (ECPBs) to seamlessly link WE with Li-NRR in a three-compartment flow reactor comprising an aqueous anode, an organic cathode, and a gas feed chamber. POMs serve as proton shuttles while suppressing the competing hydrogen evolution reaction (HER), facilitating efficient ammonia synthesis. The addition of polymethyl methacrylate (PMMA) enhances catholyte hydrophobicity, mitigating water contamination. By optimizing ECPB concentration, a dynamic balance is achieved between lithium nitride intermediates (LiNxHy) formation and consumption, yielding ammonia at 573.7 ± 5.2 µg h⁻¹ cm⁻ 2 with a Faradaic efficiency of 54.2%. This design advances flow reactor technology by uniquely utilizing water oxidation as a direct proton source, bypassing conventional hydrogen oxidation methods. The use of POMs as proton shuttles establishes a new benchmark for green ammonia production, reinforcing its potential in sustainable chemistry.}, archive = {J_ANGEW}, author = {Jun Miao and Cailing Chen and Li Cao and Reham Al Nuaimi and Zhen Li and Kuo-Wei Huang and Zhiping Lai}, doi = {10.1002/anie.202503465}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503465}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing lithium-mediated green ammonia synthesis with water electrolysis boosted by membrane electrolyzer with polyoxometalate proton shuttles}, volume = {64}, year = {2025}, }
• (2025). Palladium-catalyzed enantioselective arylative dearomatization of naphthols and phenols for constructing quinazoline-containing spirocycles. ANGEW, 64(27), e202503359. (www)

  @article{ , abstract = {We report a palladium-catalyzed enantioselective arylative dearomatization of phenols and naphthols, demonstrating a broad substrate scope and excellent functional group tolerance. This approach enables the efficient construction of a diverse library of quinazoline-containing spirocyclic compounds, featuring enantioenriched, three-dimensional molecular architectures through the strategic integration of quinazolinone and spirocyclic frameworks. The successful transformation of planar aromatic precursors into complex three-dimensional molecular architectures using our developed methodology was further validated by principal moment of inertia (PMI) calculations. Additionally, we systematically evaluated the antiproliferative potential of the synthesized compounds against two representative cancer cell lines: Mino (human mantle cell lymphoma) and MV4-11 (human acute myeloid leukemia), revealing that compound ( S )-4ac, characterized by well-defined stereochemistry and structural novelty, exhibited significantly enhanced antiproliferative efficacy against both cancer cell lines, with IC 50 values 0.9 µM and 0.5 µM, respectively. In addition, flow cytometry quantification and western blot analysis showed that these compounds induced apoptosis through caspase activation and mitochondrial dysfunction. These results demonstrated ( S )-4ac as a highly promising lead compound for further anticancer drug development.}, archive = {J_ANGEW}, author = {Chiyue Zhang and Gaoya Xu and Wenlu Zhao and Xutong Li and Mingyue Zheng and Yubo Zhou and Jia Li and Qi Li}, doi = {10.1002/anie.202503359}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503359}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Palladium-catalyzed enantioselective arylative dearomatization of naphthols and phenols for constructing quinazoline-containing spirocycles}, volume = {64}, year = {2025}, }
• (2025). Chiroptical signal inversion of peptido-coassemblies in confined parallel-laminar microfluidics. ANGEW, 64(27), e202503284. (www)

  @article{ , abstract = {Chirality plays a vital role in material properties, and precise control of chiral signals is key to designing functional materials. Supramolecular self-assembly offers an efficient means to integrate chiral building blocks with chromophores, yet controlling the assembly pathway remains challenging due to the complexity of non-covalent interactions. Here, we introduce a continuous parallel-laminar-assisted self-assembly strategy that exploits solvent ordering and solute diffusion in confined environments to regulate chiral signals in multi-component peptide co-assemblies. Notably, six nonpolar amino acids exhibit significantly enhanced chiroptical responses, as confirmed by circular dichroism (CD) and circularly polarized luminescence (CPL) spectroscopy. Intriguingly, Fmoc-Ala and 1-aminopyrene ( AP ) co-assemblies formed in a microfluidic chip show a reversed chiroptical signal compared to those from batch reactions. Molecular dynamics (MD) simulations and COMSOL modeling suggest that velocity gradients and shear forces in microfluidics induce ordered non-covalent interactions, altering excimer stacking and modulating chiroptical properties. This study presents an effective strategy for controlling chiral optical signals in confined environments, offering an interesting approach for supramolecular chiral transfer and regulation.}, archive = {J_ANGEW}, author = {Jianjian Zhao and Wei-Tao Dou and Wanding Cui and Xueliang Shi and Xiaodong Li and Junfeng Fang and Xuhong Qian and Hai-Bo Yang and Lin Xu}, doi = {10.1002/anie.202503284}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503284}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiroptical signal inversion of peptido-coassemblies in confined parallel-laminar microfluidics}, volume = {64}, year = {2025}, }
• (2025). Thrombus boring microrobot prepared by an integrated phase separation and interfacial self-assembly process toward thrombolysis. ANGEW, 64(27), e202503221. (www)

  @article{ , abstract = {The pathological formation of thrombi is the primary etiological factor of acute cardiovascular and cerebrovascular diseases, accounting for one-quarter of global fatalities. Traditional thrombolytic drugs are constrained by short half-life, low utilization, and severe complications. Inspired by the tunnel boring machine to excavate strata into small rocks, we report urokinase plasminogen activator (uPA)-modified thrombus boring microrobots (uTBMs), prepared by a one-step integrated phase separation and interfacial self-assembly process, for effective thrombolysis. The uTBMs are composed of microspheres capped with dual-layered structures of magnetic nanoparticles (MNPs) and cilia nanostructures. In situ observation reveals the integrated phase separation and interfacial self-assembly process of the uTBM within an emulsion droplet. The capped layer of MNPs allows for controllable motion and rotation behavior under the manipulation of a remote magnetic field. The uPA-modified cilia nanostructures grasp and degrade the fibrin network, synergizing with the uTBMs rotation to mechanically excavate blood cells from thrombus individually, achieving ∼8.5-fold higher thrombolytic efficacy than uPA alone. This research demonstrates the feasibility of controllably fabricating and modifying complex-structured microrobots via the simple process toward potential thrombus therapy.}, archive = {J_ANGEW}, author = {Han Bao and Sen Zhang and Jing Luo and Jingxin Meng and Shutao Wang}, doi = {10.1002/anie.202503221}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thrombus boring microrobot prepared by an integrated phase separation and interfacial self-assembly process toward thrombolysis}, volume = {64}, year = {2025}, }
• (2025). Inverted chiroptical properties of hybrid metal halides through reversible chiral induction driven by external and internal chirality transfer. ANGEW, 64(27), e202503083. (www)

  @article{ , abstract = {Chiral organic-inorganic hybrid metal halides (OIHMHs) are commonly constructed by introducing pairs of enantiomorphic chiral precursors through a single chirality transfer pathway, which may limit the regulation of chiral structural diversity and chiroptoelectronic properties. Herein, we propose a new strategy for achieving reversible chiral induction of OIHMHs with inverted chiroptical properties through external and internal chirality transfer pathways, by utilizing a single chiral reagent R -/ S - α -methylbenzylamine ( R -/ S -MBA). Specifically, R -MBA can externally induce chiral enrichment of M -DMA 4 (Bi 0.486 In 0.511 Sb 0.003 )Cl 7 ( M -DMA 4 (Bi-In-Sb)Cl 7 , DMA = dimethylammonium cation) without integrating into structure. Conversely, R -MBA can insert into structure, internally inducing the formation of DMA( R -MBA) 2 (Bi 0.634 In 0.362 Sb 0.004 )Cl 6 (DMA( R -MBA) 2 (Bi-In-Sb)Cl 6 ), which reverses the structural arrangements and inverts both linear and nonlinear chiroptical properties. Both externally and internally induced chiral OIHMHs exhibit significant chiroptical responses with high photoluminescence quantum yield (PLQY) and second harmonic generation (SHG). Moreover, the externally induced centimeter-sized rhombic single crystal enables morphology- and angle-dependent inverted circularly polarized luminescence with a dissymmetry factor of ∼0.02, through single crystal anisotropy. The internal induction enhances SHG intensity by nine-fold and increases PLQY to 98.9%. This multi-path chirality transfer, based on a single chiral reagent, can significantly broaden the structural scope of functional chiral OIHMH materials and facilitate the regulation of chiroptoelectronic properties.}, archive = {J_ANGEW}, author = {Junjie Guan and Wenqing Han and Youpei Zhang and Jiuzhou Zhao and Shanshan Han and Yue Wang and Bona Fu and Hanwen Kang and Peihan Wang and Puxin Cheng and Yongshen Zheng and Jialiang Xu and Xian-He Bu}, doi = {10.1002/anie.202503083}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503083}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inverted chiroptical properties of hybrid metal halides through reversible chiral induction driven by external and internal chirality transfer}, volume = {64}, year = {2025}, }
• (2025). Biomass-derived functional polyacetals via controlled cascade enyne metathesis polymerization: Tunable degradability, postpolymerization modification, and self-assembly. ANGEW, 64(27), e202503022. (www)

  @article{ , abstract = {We present a versatile platform for the synthesis of functional polyacetals from sugar and furfuryl alcohol derivatives using controlled cascade enyne metathesis polymerization. A range of monomers with defined stereochemistry were explored that featured broad functional group tolerance. The polymerization showed living character and permitted preparation of functionalized polyacetals with targetable molecular weights and more complex architectures. In addition, by harnessing the chiral nature of starting materials, the method granted facile access to chiral polyacetals. Modulation of regiochemical and substituent factors around the acetal motif conferred tunable hydrolysis rate, as well as photodegradability when installed with an ortho -nitrobenzyl group. The polymer structure was further elaborated by postpolymerization modification via leveraging the reactivity of suitable pendent groups and preparation of fully degradable bottlebrush polymers via graft-through polymerization. Further utilities of the method were showcased by the preparation of amphiphilic copolymers with complete degradability that exhibited self-assembly behaviors through copolymerization.}, archive = {J_ANGEW}, author = {Yuan Tao and Bixia Xie and Jingrong Liu and Changquan Lin and Yanli Feng and Jiazhou Jiang and Yuhan Peng and Lijun Liu and Junpeng Zhao and Liangbing Fu}, doi = {10.1002/anie.202503022}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202503022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biomass-derived functional polyacetals via controlled cascade enyne metathesis polymerization: Tunable degradability, postpolymerization modification, and self-assembly}, volume = {64}, year = {2025}, }
• (2025). Pyrazine-embedded 2D conjugated Metal–Organic framework with quasi-honeycomb lattice for high-capacitance lithium-ion storage. ANGEW, 64(27), e202502988. (www)

  @article{ , abstract = {As a unique class of framework electronic materials, 2D conjugated metal–organic frameworks (2D c -MOFs) exhibit intrinsic porosity, superior electrical conductivity, and abundant active sites. These properties endow them with great potential in electrochemical lithium-ion storage. However, the development of 2D c -MOF-based capacitors has encountered a bottleneck in enhancing Li-ion storage capacitance, and the design of high-capacitance MOF electrode materials has remained a challenge. Herein, we synthesize a Cu-OHDDQP (octahydroxy-dibenzo[ a , c ]dibenzo[5,6:7,8]quinoxalino[2,3- i ]phenazine) 2D c -MOF with a quasi-honeycomb lattice by employing a nonplanar D 2 -symmetric conjugated ligand embedding redox-active pyrazine moieties. The quasi-honeycomb lattice features a dual-porous tessellation of C 6 -symmetric and C 3 -symmetric pores. Notably, when utilized as active material for electrochemical lithium storage, Cu-OHDDQP achieves a record-high gravimetric specific capacitance among reported 2D c -MOFs of 452 F g −1 in aqueous lithium electrolyte, along with a decent cycling stability of 90% after 1000 cycles. Such high capacitance is attributed to both the quasi-honeycomb lattice leading to higher surface area and the redox-active pyrazine moieties offering extra lithium-adsorption sites and associated pseudocapacitance. This work demonstrates that rational ligand design enables high-capacitance MOF electrodes materials, highlighting the potential of conductive MOFs for electrochemical energy technologies.}, archive = {J_ANGEW}, author = {Xiangyu Li and Yangyang Feng and Shuai Fu and Tianrui Wu and Peng Liang and Xicheng Ma and Rashid Iqbal and Yuzhen Qian and Yandong Ma and Mischa Bonn and Hua Wang and Hongjie Dai and Jingcheng Hao and Renhao Dong}, doi = {10.1002/anie.202502988}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502988}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pyrazine-embedded 2D conjugated Metal–Organic framework with quasi-honeycomb lattice for high-capacitance lithium-ion storage}, volume = {64}, year = {2025}, }
• (2025). On-membrane supramolecular assemblies serving as bioorthogonal gating for melphalan. ANGEW, 64(27), e202502922. (www)

  @article{ , abstract = {Covalent drugs have experienced a revival in recent decades due to their advantageous pharmacodynamic profiles and targeting of “undruggable” proteins. However, balancing selectivity, reactivity, and potency is essential for safe and effective drugs. Here, we employ a cell-selective bioorthogonal prodrug design to enhance the selectivity for covalent inhibitors without compromising the reactivity and potency. The upregulation of phosphatase and integrin facilitates the formation of enzyme-instructed supramolecular assemblies (EISA) on the cancer cell membrane. These assemblies localize bioorthogonal reaction handles tetrazine (Tz), which liberate Melphalan from its bioorthogonal prodrug TCO-Mel. The TCO modification disrupts the LAT1-mediated transportation, reducing cellular permeability of TCO-Mel and the corresponding cytotoxicity to normal cells. Although the cell-selective on-membrane assemblies directed prodrug activation restores Melphalan influx to inhibit cancer cell growth. This prodrug activation strategy further demonstrates potent tumor suppression with satisfactory biocompatibility in vivo. Overall, we extend the scope of bioorthogonal prodrug design for covalent drugs via regulating cellular influx of active pharmaceutical ingredients (APIs).}, archive = {J_ANGEW}, author = {Hanlin Xu and Qingxin Yao and Xiaoqian Hu and Debin Zheng and Chao Ren and Zhibin Ren and Yuan Gao}, doi = {10.1002/anie.202502922}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502922}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-membrane supramolecular assemblies serving as bioorthogonal gating for melphalan}, volume = {64}, year = {2025}, }
• (2025). Introducing photochemical action plots as a tool for unlocking On–Off switchable behavior in a polymeric eosin y photocatalyst. ANGEW, 64(27), e202502890. (www)

  @article{ , abstract = {Photochemical action plots are a powerful tool for investigating the wavelength-dependent efficiency of photochemical processes. Herein, we apply the photochemical action plot methodology developed by the Barner–Kowollik team to a photocatalytic reaction, resulting in the first examples of photocatalytic action plots, paving the way for future in-depth explorations of the wavelength dependence of similar reactions. Specifically, we investigate the wavelength dependence of the catalytic oxidation capabilities of an Eosin Y functionalized polymer photocatalyst ( P1 ) as well as a small molecule representative of the polymer bound Eosin Y moieties ( EY ) for the oxidation of triphenylphosphine. Introduction of zinc(II) ions into the system proved to drastically influence the optical absorption properties of both catalysts, accompanied by a pronounced influence on their wavelength-dependent reactivity profiles which is not predictable based on the absorption spectra. For P1 , these changes can be reversed by metal-mediated single-chain nanoparticle (SCNP) formation upon base addition, giving access to a stimuli-responsive polymeric photocatalyst. Detailed analysis of the photocatalytic action plots enabled the identification of a suitable wavelength for the realization of an on-off switchable polymeric photocatalytic system.}, archive = {J_ANGEW}, author = {Sebastian Gillhuber and Alicia K. Finch and Joshua O. Holloway and Hendrik Frisch and Florian Weigend and Christopher Barner-Kowollik and Peter W. Roesky}, doi = {10.1002/anie.202502890}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502890}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Introducing photochemical action plots as a tool for unlocking On–Off switchable behavior in a polymeric eosin y photocatalyst}, volume = {64}, year = {2025}, }
• (2025). Integrative lattice and surface engineering of nanoscale fe0 for superior dechlorination of trichloroethene in groundwater: Coordination in reactivity, selectivity, and stability. ANGEW, 64(27), e202502867. (www)

  @article{ , abstract = {Nanoscale zero-valent iron (nFe 0 ) materials hold great promise in environmental remediation, yet achieving high reactivity, selectivity, and stability in reduction remains a long-standing challenge. Here we address this challenge by employing Ni lattice and FeS surface engineering to fabricate novel nFe 0 -based nanomaterials (dubbed as FeNi x @FeS y ), featuring FeNi as the core and FeS as the shell. The FeNi 5 @FeS 10 delivered approximately 242.7- and 81.2-times higher reactivity and selectivity, respectively, over unmodified nFe° for the remediation of trichloroethene (TCE; a notorious environmental pollutant), while maintaining high stability in groundwater remediation. We found that the core composition (i.e., Ni/Fe ratio) of FeNi x @FeS y primarily determined reactivity, governed by a tradeoff between the galvanic effect and lattice strain, while shell properties mainly controlled selectivity, despite some interactions between them. Density functional theory (DFT) calculations revealed that the FeS surface served as a favorable adsorption site for TCE, and the low energy barriers (TS2, 0.19 eV) of FeNi 5 @FeS 10 facilitated the cleavage of the first chlorine from TCE. Moreover, the core-shell structure promoted electron transfer from the core to the shell and TCE. This integrative lattice and surface engineering strategy provides a new avenue for designing advanced functional materials for environmental remediation and beyond.}, archive = {J_ANGEW}, author = {Feilong Gao and Guofang Xu and Mingyi Zhang and Honghong Lyu and Han Wu and Jingchun Tang and Xinhua Xu and Jianzhong He}, doi = {10.1002/anie.202502867}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502867}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrative lattice and surface engineering of nanoscale fe0 for superior dechlorination of trichloroethene in groundwater: Coordination in reactivity, selectivity, and stability}, volume = {64}, year = {2025}, }
• (2025). Cyclic trinuclear units based covalent metal-organic frameworks for gold recovery. ANGEW, 64(27), e202502749. (www)

  @article{ , abstract = {The development of porous solids for gold recovery is highly desired from both an economical and environmental point of view; however, the design of solid adsorbents with high overall performance is still challenging. Herein, we designed three copper(I) cyclic trinuclear units, Cu(I)-CTUs, based covalent metal-organic frameworks (CMOFs) by networking metal clusters with dynamic covalent linkages. These CMOFs deliver a high gold adsorption capacity of 3687 mg g −1 , ultra-fast adsorption kinetics (i.e., removal efficiency > 99% within 20 s), excellent selectivity and reusability. In addition, they can be readily used for gold extraction from e-waste. Owing to the rich redox properties of Cu-CTUs, these CMOFs show three sorption mechanisms including adsorption, chemical reduction and photocatalytic reduction. Interestingly, the gold-loaded CMOFs can be used as catalysts for hydration of alkynes to ketones with high yields (e.g., up to ∼ 95% for 6 examples).}, archive = {J_ANGEW}, author = {Jie Luo and Jia-Tong Lin and Xiao Luo and Na Yin and Mo Xie and Xu Chen and Ying-Qiang Li and Yang-Guang Li and Guo-Hong Ning and Dan Li}, doi = {10.1002/anie.202502749}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyclic trinuclear units based covalent metal-organic frameworks for gold recovery}, volume = {64}, year = {2025}, }
• (2025). Tailoring zn-ion solvation structures for enhanced durability and efficiency in Zinc–Bromine flow batteries. ANGEW, 64(27), e202502739. (www)

  @article{ , abstract = {Aqueous zinc-bromine flow batteries (ZBFBs) are among the most appealing technologies for large-scale stationary energy storage due to their scalability, cost-effectiveness, safety and sustainability. However, their long-term durability is challenged by issues like the hydrogen evolution reaction (HER) and dendritic zinc electroplating. Herein, we address these challenges by reshaping the Zn 2+ ion solvation structures in zinc bromide (ZnBr 2 ) aqueous electrolytes using a robust hydrogen bond acceptor as a cosolvent additive. Our findings highlight the critical role of interactions within the first and second Zn 2+ solvation shells in determining electrochemical performance. By selectively incorporating a low volume percentage of organic additive into the second coordination shell of Zn 2+ , we achieve effective proton capture, electrolyte pH stabilization during the Zn 0 electroplating, and mitigation of ion transport resistance. This approach prevents the formation of a passivation interphase layer on the electrode surface, which typically occurs with higher additive concentrations, leading to increased interphase resistance and cell polarization. This work opens a new avenue in modulating Zn 2+ reactivity and stability through precise solvation structure design, enabling efficient and reversible Zn 0/2+ plating/stripping in aqueous electrolytes with suppressed H 2 evolution. These findings pave the way for the development of commercially viable, high-performance ZBFBs for energy storage applications.}, archive = {J_ANGEW}, author = {Norah S. Alghamdi and Dmitrii Rakov and Xiyue Peng and Jaeho Lee and Yongxin Huang and Xingchen Yang and Shuangbin Zhang and Ian R. Gentle and Lianzhou Wang and Bin Luo}, doi = {10.1002/anie.202502739}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502739}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring zn-ion solvation structures for enhanced durability and efficiency in Zinc–Bromine flow batteries}, volume = {64}, year = {2025}, }
• (2025). Unprecedented tetravalent uranium photocatalysts for efficient C(sp3)─C(sp3) bond cleavage and formation. ANGEW, 64(27), e202502634. (www)

  @article{ , abstract = {Photocatalysis is a pivotal area in synthetic chemistry. Despite extensive application potential in nuclear industry, uranium-based photocatalysts are historically limited to uranyl(VI/V) redox cycle. Here, we report the discovery of the first tetravalent uranium [U(IV)] photocatalyst that enables efficient C(sp 3 )─C(sp 3 ) bond cleavage and formation under ideal visible light . The U(IV) alkoxy species mediates C─C bond cleavage in a wide range of cycloalkanols and promotes their coupling with electron-deficient alkenes, providing access to previously unattainable molecular architectures. These U(IV) alkoxy complexes, fully characterized by X-ray diffraction and magnetic studies, exhibit exceptional photocatalytic efficiency. Quantum chemical studies reveal that the energy barrier for C─C bond cleavage and formation is reduced to below 10 kcal · mol −1 under visible light excitation. This work introduces a new mechanistic paradigm for uranium-based photocatalysis and positions U(IV) alkoxy complexes as a versatile platform for bond activation and functionalization, expanding the potential applications of depleted uranium in synthetic chemistry.}, archive = {J_ANGEW}, author = {Xingxing Gong and Lian-Wei Ye and Zong-Chang Han and Yue Zhao and Jin Xie and Han-Shi Hu and Jun Li and Congqing Zhu}, doi = {10.1002/anie.202502634}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502634}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unprecedented tetravalent uranium photocatalysts for efficient C(sp3)─C(sp3) bond cleavage and formation}, volume = {64}, year = {2025}, }
• (2025). Plasmonic ion diode membrane (PIDM) for enhanced nanofluidic ion transport. ANGEW, 64(27), e202502591. (www)

  @article{ , abstract = {Efficient applications of nanofluidic devices are often limited by the insufficient ion permselectivity and inherent ion concentration polarization (ICP) phenomenon. In this work, a bio-inspired plasmonic ion diode membrane (PIDM) was designed and fabricated for enhanced ion transport and osmotic energy harvesting by integrating covalent organic frameworks (COFs) and three-dimensional Au nanoparticles (3D AuNPs) into anode aluminum oxide (AAO). Under light irradiation, localized surface plasmon resonance (LSPR) excitation of 3D AuNPs can release huge plasmonic heat and produce abundant hot charge carriers (hot electrons and holes) simultaneously. The former heats the solution and generates a thermal gradient for boosting ion flux, while the latter transfers to the COFs layer, increasing charge density for promoting ion permselectivity. Importantly, it has been found that different COFs with varied pore sizes and charges have an obvious influence on energy harvesting efficiency. Under the optimum condition, a high output power density of 65.7 W m −2 in a 500-fold concentration gradient could be achieved. This work provides a practical and efficient way to boost ion transport and enhance osmotic energy conversion by utilizing the synergistic effect of plasmonics and ion diode (ID) property.}, archive = {J_ANGEW}, author = {Jia-Nan Chang and Kun Yang and Li-Na Wang and Jin Wang and Ya-Qian Lan and Chen Wang}, doi = {10.1002/anie.202502591}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502591}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plasmonic ion diode membrane (PIDM) for enhanced nanofluidic ion transport}, volume = {64}, year = {2025}, }
• (2025). Scalable main group mechanocatalytic CO2 valorisation to cyclocarbonate species. ANGEW, 64(27), e202502584. (www)

  @article{ , abstract = {Over the past two decades, main group elements have gained attention as promising substitutes for precious metals in catalytic processes. Additionally, mechanochemistry is emerging as a field with the potential to promote catalytic reactions under mild conditions. Herein, we report a scalable, main-group mechanocatalytic synthesis of cyclic carbonates from both solid and liquid epoxides, using CO₂ as a renewable feedstock under mild conditions with a gallium aminotrisphenolate catalyst. Unlike solution-based methods that generally require high temperatures and/or high CO₂ pressures, this mechanocatalytic process operates at just 1 bar and room temperature. The developed mechanochemical method affords the targeted compounds in high yields while also enabling efficient transformation of multi-terminal epoxides and avoiding the conversion losses typically observed in solution. Furthermore, this scalable method outperforms solution-based approaches across all green metrics, setting a new benchmark for environmentally friendly synthesis.}, archive = {J_ANGEW}, author = {Javier F. Reynes and Lucia Álvarez-Miguel and F. Winkelmann and M. Felderhoff and Marta E. G. Mosquera and Christopher J. Whiteoak and Felipe García}, doi = {10.1002/anie.202502584}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable main group mechanocatalytic CO2 valorisation to cyclocarbonate species}, volume = {64}, year = {2025}, }
• (2025). 2D conjugated Metal–Organic frameworks as electrocatalysts for boosting glycerol upgrading coupled with hydrogen production. ANGEW, 64(27), e202502425. (www)

  @article{ , abstract = {The valorisation of glycerol using renewable electricity is recognised as an effective and attractive approach for producing high-value compounds from biomass byproducts. 2D conjugated metal–organic frameworks (2D c-MOFs) have emerged as promising electrocatalysts due to their tunable structures, high electronic conductivity, and efficient utilisation of well-defined active centres. In this study, we report the first systematic investigation of 2D c-MOFs containing Ni-X 4 (X = O or N) moieties for the glycerol oxidation reaction (GOR), examining key factors influencing both electrocatalytic activity and selectivity. In situ 13 C electrochemical nuclear magnetic resonance and Raman spectroscopies provide insights into the GOR mechanism and confirm that Ni–O 4 sites are the primary active centres. Theoretical calculations further reveal that [Ni 3 (HHTQ) 2 ] n (HHTQ = 2,3,7,8,12,13-hexahydroxytricycloquinazoline) exhibits superior GOR activity due to strong adsorption of reaction intermediates and weak interlayer interactions. This work highlights the potential of 2D c-MOFs as highly efficient GOR catalysts, paving the way for the rational design of advanced electrocatalysts and contributing to the development of sustainable energy conversion and storage technologies.}, archive = {J_ANGEW}, author = {Yutong Luo and Michael Beerbaum and Stefan Röher and Sara Amanzadeh Salout and Volodymyr Bon and Yang Lu and Leonid Shupletsov and Ankita De and Xinliang Feng and Inez M. Weidinger and Thomas D. Kühne and Arafat Hossain Khan and Irena Senkovska and Stefan Kaskel}, doi = {10.1002/anie.202502425}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202502425}, shortjournal = {Angew. Chem. Int. Edit.}, title = {2D conjugated Metal–Organic frameworks as electrocatalysts for boosting glycerol upgrading coupled with hydrogen production}, volume = {64}, year = {2025}, }
• (2025). LC-MS and high-throughput data processing solutions for lipid metabolic tracing using bioorthogonal click chemistry. ANGEW, 64(27), e202501884. (www)

  @article{ , abstract = {Tracing lipid metabolism in mammalian cells presents a significant technological challenge due to the vast structural diversity of lipids involved in multiple metabolic routes. Bioorthogonal approaches based on click chemistry have revolutionized analytical performance in lipid tracing. When adapted for mass spectrometry (MS), they enable highly specific and sensitive analyses of lipid transformations at the lipidome scale. Here, we advance this approach by integrating liquid chromatography (LC) prior to MS detection and developing a software-assisted workflow for high-throughput data processing. LC separation resolved labeled and unmodified lipids, enabling qualitative and quantitative analysis of both lipidome fractions, as well as isomeric lipid species. Using synthetic standards and endogenously produced alkyne lipids, we characterized LC-MS behavior, including preferential adduct formation and the extent of in-source fragmentation. Specific fragmentation rules, derived from tandem MS experiments for 23 lipid subclasses, were implemented in Lipostar2 software for high-throughput annotation and quantification of labeled lipids. Applying this platform, we traced metabolic pathways of palmitic and oleic acid alkynes, revealing distinct lipid incorporation patterns and metabolic bottlenecks. Altogether, here we provide an integrated analytical and bioinformatics platform for high-throughput tracing of lipid metabolism using LC-MS workflow.}, archive = {J_ANGEW}, author = {Palina Nepachalovich and Stefano Bonciarelli and Gabriele Lombardi Bendoula and Jenny Desantis and Michela Eleuteri and Christoph Thiele and Laura Goracci and Maria Fedorova}, doi = {10.1002/anie.202501884}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202501884}, shortjournal = {Angew. Chem. Int. Edit.}, title = {LC-MS and high-throughput data processing solutions for lipid metabolic tracing using bioorthogonal click chemistry}, volume = {64}, year = {2025}, }
• (2025). Metal-organic frameworks at the edge of stability: Mediating node distortion to access metastable nanoparticle polymorphs. ANGEW, 64(27), e202501813. (www)

  @article{ , abstract = {Metal-organic frameworks (MOFs) are emerging as unconventional precursors for nanoparticle synthesis, with potential to leverage their tunable structures and chemistry to achieve nanomaterials with structures and compositions inaccessible via traditional synthetic routes. Here, we use in situ synchrotron X-ray diffraction and pair distribution function (PDF) measurements to investigate how the dynamic structure of MOFs at the edge of stability influences their transformation into different metastable polymorphs. Our study reveals that the local structural features of metal-oxo MOF nodes at elevated temperatures are linked to the resulting nanoparticle structures formed under mild conditions. Focusing on the titanium-based MOF MIL-125, we demonstrate that manipulating the chemical environment to facilitate transformation of the Ti 8 node geometry promotes formation of metastable, nanometer-scale TiO 2 brookite rather than the more common anatase and rutile TiO 2 polymorphs typically produced through MOF pyrolysis at high temperature. These findings highlight the potential to harness the MOF topology and chemical environment to design and control node distortions and enable access to exotic metastable nanoparticle states.}, archive = {J_ANGEW}, author = {Zhihengyu Chen and Simon M. Vornholt and Jacob T. Bryant and Fernando Uribe-Romo and Karena W. Chapman}, doi = {10.1002/anie.202501813}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202501813}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-organic frameworks at the edge of stability: Mediating node distortion to access metastable nanoparticle polymorphs}, volume = {64}, year = {2025}, }
• (2025). Organic cage encapsulated within metal cluster-based open frameworks: A single-crystal host-in-host material with inter-host charge cooperation. ANGEW, 64(27), e202501803. (www)

  @article{ , abstract = {Integrating dissimilar building units of discrete organic cages and inorganic clusters into single-crystal supramolecular frameworks with tailored architectures and synergistic functions presents a significant challenge. Here, we presented our discovery of achieving such hybrids through electrostatically driven self-assembly of cationic ammonium organic cages with anionic lead iodide clusters. Notably, by carefully modulating the size, shape, and composition of cationic organic cages, we have constructed an integrated porous host-in-host architecture. In this system, the internal cationic cage snugly resided, encapsulated within the external network constructed from anionic lead iodide clusters. This unique nested hierarchy showcased enhanced interhost interactions facilitated by electrostatic forces, which intricately tailored the electronic structure of the outer lead iodide moiety. As a result, the hybrid demonstrated distinguished photophysical properties, including efficient oxygen activation and enhanced photothermal conversion capability, as confirmed by comprehensive experimental and theoretical analyses. The critical role of interhost electrostatic interactions was further demonstrated through a systematic comparison with a structurally similar host-in-host architecture comprising lead iodide clusters and neutral amine cages. Furthermore, the integrated and compartmentalized dual-host served as spatially isolated dual active sites for cascade reactions, exhibiting 33–47-folds enhancement in activity compared to structural counterparts lacking charge cooperation.}, archive = {J_ANGEW}, author = {Zhao-Feng Wu and Jing-Wang Cui and Ke Zhao and Bin Tan and Si-Hua Liu and Xiao-Ying Huang and Jian-Ke Sun and Guo-Yu Yang}, doi = {10.1002/anie.202501803}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202501803}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic cage encapsulated within metal cluster-based open frameworks: A single-crystal host-in-host material with inter-host charge cooperation}, volume = {64}, year = {2025}, }
• (2025). Protonated glutamate and aspartate side chains can recognize phosphodiester groups via strong and short hydrogen bonds in biomacromolecular complexes. ANGEW, 64(27), e202501589. (www)

  @article{ , abstract = {Phosphodiester groups occur ubiquitously in nature, e.g. in nucleic acids or in cyclic (di-)nucleotides important for signal transduction. Proteins often use polar or positively charged amino acids to interact with the negatively charged phosphodiester groups via hydrogen bonds and salt bridges. In contrast, the acidic amino acids aspartate and glutamate are generally not considered as important determinants for phosphodiester group recognition. Instead, they are regarded as detrimental to such interactions due to the assumed charge repulsion between their deprotonated, negatively charged side chain carboxylate groups and the phosphodiester. Accordingly, acidic amino acids are often purposefully introduced into proteins to abrogate nucleic acid interactions in functional studies. Here, we show that in appropriate structural contexts, glutamate side chains are readily protonated even at neutral pH and act as hydrogen bond donors to phosphodiester groups using a c-di-GMP binding protein – the GSPII-B domain of PilF from Thermus thermophilus – as an example. Surveying available RNA-protein and DNA-protein complex structures in the PDB, we found that hydrogen bonds between apparently protonated carboxylate groups of glutamate and aspartate and phosphodiester groups occur frequently in many different functional protein classes. Thus, the functional role of acidic amino acids in phosphodiester group recognition needs to be re-evaluated.}, archive = {J_ANGEW}, author = {Konstantin Neißner and Elke Duchardt-Ferner and Christoph Wiedemann and Julian Kraus and Ute A. Hellmich and Jens Wöhnert}, doi = {10.1002/anie.202501589}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202501589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Protonated glutamate and aspartate side chains can recognize phosphodiester groups via strong and short hydrogen bonds in biomacromolecular complexes}, volume = {64}, year = {2025}, }
• (2025). Single-atom fe catalysts with improved metal loading for efficient ammonia synthesis under mild conditions. ANGEW, 64(27), e202501190. (www)

  @article{ , abstract = {Ammonia synthesis is a cornerstone in the chemical industry. Given that the traditional Haber–Bosch (H-B) process requires very high temperature and pressure, it is imperative to develop catalysts capable of facilitating ammonia synthesis under mild conditions. In this work, a post-metal replacement strategy is developed to improve the Fe loading in single-atom Fe-implanted N-doped carbon catalysts. Starting from the Zn–Fe–N–C material with single-atom Zn and Fe sites coexisting in N-doped porous carbon pyrolyzed from porphyrinic metal–organic frameworks (MOFs), the replacement of single-atom Zn with Fe sites is performed, which significantly increases the Fe loading from 1.33 to 2.39 wt%. This effectively suppresses the migration and agglomeration of Fe, yielding Fe–N–C with high metal loading (Fe HL –N–C). Notably, the Fe HL –N–C catalyst exhibits a catalytic rate of 558 µmol·g cat −1 ·h −1 at 300 °C for ammonia synthesis at atmospheric pressure, far surpassing the performance of the traditional dominant fused iron and even Ru-based precious metal catalysts.}, archive = {J_ANGEW}, author = {Yuting Jiang and Ziquan Chen and Tao Peng and Long Jiao and Xiulian Pan and Hai-Long Jiang and Xinhe Bao}, doi = {10.1002/anie.202501190}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202501190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-atom fe catalysts with improved metal loading for efficient ammonia synthesis under mild conditions}, volume = {64}, year = {2025}, }
• (2025). Bulk measurement of membrane permeability for random cyclic peptides in living cells to guide drug development. ANGEW, 64(27), e202500493. (www)

  @article{ , abstract = {Cyclic peptides are attractive for drug discovery due to their excellent binding properties and the potential to cross cell membranes. However, by far, not all cyclic peptides are cell permeable, and measuring or predicting their membrane permeability is not trivial. In this work, we assessed the membrane permeability of thioether-cyclized peptides, a widely used format in drug discovery. We developed a strategy for synthesizing hundreds of cyclic peptides carrying a short chloroalkane tag for the bulk quantification of membrane permeability in live cells using the chloroalkane penetration assay. Permeability data for random cyclic peptides established design rules, indicating the probability of peptides entering cells is strongly increasing if the molecular weight is below 800 Da, the polar surface is smaller than 250 Å 2 , or if there are less than six hydrogen bond donors. From this, machine learning could predict the membrane permeability of random peptides with good confidence, facilitating the future development of membrane-permeable cyclic peptide drugs.}, archive = {J_ANGEW}, author = {Alexander L. Nielsen and Christian R. O. Bartling and Anne Zarda and Nathan De Sadeleer and Rebecca M. Neeser and Phillippe Schwaller and Kristian Strømgaard and Christian Heinis}, doi = {10.1002/anie.202500493}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202500493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bulk measurement of membrane permeability for random cyclic peptides in living cells to guide drug development}, volume = {64}, year = {2025}, }
• (2025). Chemically fueled active transport. ANGEW, 64(27), e202500243. (www)

  @article{ , abstract = {Biology uses chemical potential differences from molecules like ATP to drive membrane pumps, transporting molecules across membranes even against concentration gradients. Here, we report a synthetic system that transports small molecules from an aqueous phase (the sender) to an aqueous receiver across a centimeter-sized immiscible solvent at the expense of chemical energy. Molecules with high chemical potential (fuels) in the sender phase transiently activate the transporter molecules, which enter the immiscible solvent and exit on the receiver phase side, thus allowing transport from sender to receiver against a concentration gradient. Importantly, we show this active transport mechanism transports molecules across a hydrophobic barrier without complex pumping machinery. Using a reaction-diffusion model, we identify the critical parameters that determine the efficiency of active transport. Selective transport enables the sorting of a mixture of different molecules. In future work, we will use these design criteria to actively transport molecules across membranes, e.g., of vesicles, at the expense of chemical fuel, thereby mimicking biological processes and enabling the feeding of synthetic cells.}, archive = {J_ANGEW}, author = {Christine M. E. Kriebisch and Brigitte A. K. Kriebisch and Gregor Häfner and Héctor Soria-Carrera and Yanyan Fei and Marcus Müller and Job Boekhoven}, doi = {10.1002/anie.202500243}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202500243}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemically fueled active transport}, volume = {64}, year = {2025}, }
• (2025). Halogen bonding enable improved performance and stability of Dion–Jacobson perovskite solar cells. ANGEW, 64(27), e202500131. (www)

  @article{ , abstract = {The undesired phase distribution and intrinsic residual lattice strain remain the bottleneck for high-performance and stable 2D or Q-2D perovskite solar cells (PSCs), especially for the Dion–Jacobson (DJ) type Q-2D PSCs. Here, we showcase employing halogen bonds to stabilize the halide anions and fine-tuning the residual lattice strain by introducing perfluorodecyl iodide (PFI). It reduces the density of iodide species defects and releases the residual tensile strain, leading to more homogenous phase distribution, suppressed carrier recombination, promoted charge transport, enhanced efficiency, and stability. Therefore, DJ PSCs maintain over 81% of initial efficiency after thermal-light aging (i.e., under 85 °C and 1 sun illumination) for 952 h, and remain over 91% of initial efficiency after under reverse bias (−2.5 V, under ISOS-V aging tests) for over 21 h, representing one of the most bias-stable Q-2D PSCs reported so far.}, archive = {J_ANGEW}, author = {Nanliu Liu and Qingqing Zou and Ying Li and Guoting Li and Yan Chen and Rongzhou Liang and Sijin Liu and Shiwei Lu and WeiKe Wang and Bing Ji and Lili Ke and Guozheng Nie and Hongpeng Zhou and Biao Liu and Yaxin Zhai and Yuanyuan Guo and Jifei Wang}, doi = {10.1002/anie.202500131}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202500131}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogen bonding enable improved performance and stability of Dion–Jacobson perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Engineering a proximity biosensor via constitutional dynamic chemistry. ANGEW, 64(27), e202425644. (www)

  @article{ , abstract = {Affinity binding-induced DNA assembly is a fundamental principle for designing proximity biosensors for sensitive and wash-free protein detection and imaging. However, current design strategies for these biosensors face an intrinsic trade-off between binding affinity and background signal. Here, we demonstrate that this intrinsic issue can be addressed by using constitutional dynamic chemistry (CDC) as a guiding principle in the rational design of proximity biosensors. As exists in a dynamic equilibrium, the constitutional dynamic network (CDN)-based proximity biosensors can be adjusted to maximize the affinity to the target protein while minimizing non-specific interactions that contribute to background signals. By further detecting the ratio of agonist to antagonist within the CDN, we also significantly improved assay robustness, enabling the sensitive detection of antibodies in complex matrices such as human serum. With the high affinity, low background, and high robustness, we anticipate that our CDN-based design strategy will find wide applications in biosensor development. Our study also opens the possibility to engineer protein-responsive synthetic systems with complex dynamic behaviors and functions.}, archive = {J_ANGEW}, author = {Lu Gao and Ruiqi Zhang and Yanan Tang and Feng Li}, doi = {10.1002/anie.202425644}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202425644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering a proximity biosensor via constitutional dynamic chemistry}, volume = {64}, year = {2025}, }
• (2025). Natural sunlight-driven activation of inert aryl halides using plasmonic Cu@CdS with polysulfide active sites. ANGEW, 64(27), e202425601. (www)

  @article{ , abstract = {Visible light photoredox catalysis has become a rapidly emerging area owing to its potential of using sunlight to tame previously hard-to-harness radicals for organic synthesis. At present, such a blueprint faces a significant challenge, namely how to accomplish thermodynamically demanding reactions with sunlight encompassing a wide range of low-energy photons. Here, we report a new reaction framework to overcome this bottleneck through decoupling the thermodynamic limits of photoreduction from photoexcitation. This is fulfilled based on the construction of a heterogeneous photocatalyst Cu@CdS possessing in situ-formed surficial polysulfide species (including S 3 •− and S 4 2− ), which can efficiently harvest solar energy via plasmonic absorption of Cu while manifest sufficient redox potential for activating inert aryl bromides/chlorides enacted by excited polysulfides. We demonstrate that this designed material composes a potent photoredox catalyst for efficient aryl cross-coupling, borylation, hydrogenation, as well as Birch-type dearomatization reactions, with good recyclability and stability. In particular, when exclusively using natural sunlight as an energy source, the product yield can still reach up to 90%. Our findings introduce a straightforward yet viable way to progress toward the century-long dream of leveraging natural sunlight to produce structurally complex organic molecules, just like plants on Earth.}, archive = {J_ANGEW}, author = {Yuemei Li and Shi-Yu Guo and Hongfei Gu and Bingyu Wang and Peiwu Su and Xiuming Zhang and Haoqing Zhang and Shuping Zhang and Fanzhi Yang and Jia Liu and Qing-An Chen and Jiatao Zhang}, doi = {10.1002/anie.202425601}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202425601}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Natural sunlight-driven activation of inert aryl halides using plasmonic Cu@CdS with polysulfide active sites}, volume = {64}, year = {2025}, }
• (2025). Intrinsically disordered peptide nanofibers from a structured motif within proteins. ANGEW, 64(27), e202425456. (www)

  @article{ , abstract = {Intrinsically disordered regions (IDRs) are ubiquitous in proteins, orchestrating complex cellular signaling through higher-order protein assemblies. However, the properties and functions of intrinsically disordered peptide (IDP) assemblies are largely underexplored. This work unveiled a facile strategy for engineering IDP assemblies. We demonstrate that conjugating a structured motif derived from a protein's phosphorylation site to a self-assembling tripeptide unexpectedly yields self-assembled nanofibers with intrinsic disorder. Specifically, by using a glycine linker to attach a pentapeptide derived from a phosphorylation site within a random coil region of SRC kinase to the C-terminus of a widely used self-assembling enabler, we generated a phosphorylated octapeptide. The octapeptide exhibits cell compatibility and forms a hydrogel upon dephosphorylation of the phosphooctapeptide. Cryo-electron microscopy (cryo-EM) structural analysis of the nanofibers reveals that the peptides adopt two types of helical arrangements but exhibit intrinsic disorder at the periphery of the nanofibers. The hydrogels exhibit decreased protein adsorption with increasing peptide concentration. This study represents the first instance of a structured random coil within a protein transitioning into an intrinsically disordered state within self-assembled peptide nanofibers, expanding the pool of peptide sequences for IDPs and providing valuable insights for the engineering of peptide nanofibers with intrinsic disorder for the development of cell-compatible biomaterials.}, archive = {J_ANGEW}, author = {Yuchen Qiao and Ayisha Zia and Adrianna Shy and Grace Wu and Matthew Chu and Zhiyu Liu and Fengbin Wang and Bing Xu}, doi = {10.1002/anie.202425456}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202425456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intrinsically disordered peptide nanofibers from a structured motif within proteins}, volume = {64}, year = {2025}, }
• (2025). Bimetallic design based on the nucleation rate of prussian blue analogues for enhanced aqueous zinc ion batteries with Glycerol–Water hybrid electrolytes. ANGEW, 64(27), e202425391. (www)

  @article{ , abstract = {A magical heterostructures of M-PBAs (M = Co, Cu, and Zn) encapsulated by V-PBA have been successfully obtained by a facile one-pot coprecipitation method based on the difference in the binding energies of between these metal ions and ligands, and the nucleation rates of different M-PBAs. Hence, due to the multiple redox pairs, open frameworks, ordered channels, and synergistic effect of two components, the obtained VM-PBAs have been tested as cathodes in aqueous zinc-ion batteries (AZIBs). To further inhibiting the hydrolysis of vanadium ions and the collapse of PBAs structures, a series of glycerol–water hybrid electrolyte with different content of glycerol were designed. Benefiting from the multiple hydroxyl groups, appropriate viscosity and accurate proportion of glycerol, the as-assembled AZIBs with VMn-PBAs cathode can exhibit excellent cycling performance (∼73% capacity retain of stable capacity) after 1000 cycles. This work provides a sight of preparation of PBAs nanomaterials and a strategy of improve the cycling stability and rate capacity of PBAs-based cathodes in AZIBs.}, archive = {J_ANGEW}, author = {Biao Yang and Yuxin Shi and Gongjing Song and Chengang Pei and Yan Yan and Zhidong Chen and Huan Pang}, doi = {10.1002/anie.202425391}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202425391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bimetallic design based on the nucleation rate of prussian blue analogues for enhanced aqueous zinc ion batteries with Glycerol–Water hybrid electrolytes}, volume = {64}, year = {2025}, }
• (2025). Donor-π-acceptor photoinitiators for high-efficiency visible LED and sunlight polymerization and high-precision 3D printing. ANGEW, 64(27), e202425198. (www)

  @article{ , abstract = {This study presents the development and evaluation of five dyes with varying conjugated energy levels and donor-π-acceptor (D-π-A) structures as photoinitiators for free radical polymerization. Their photoinitiation efficiencies are systematically assessed under both visible-light LED and sunlight. Notably, the conversions reach up to 81% within just 30 s under sunlight, demonstrating the ultrafast and efficient polymerization capabilities of the dyes. The efficient electron transfer is facilitated by the D-π-A structure, where the conjugation is reduced or interrupted by the high distortion between the electron-withdrawing and the electron-releasing units. This distortion can prevent the overlap of frontier molecular orbitals, decreasing the energy difference between the ground state and the excited state of dyes, thereby enhancing the electron transfer reactivity with additives. Additionally, we propose a chemical mechanism for the electron transfer reaction in the three-component systems. The study also explores the application of naphtho[2,3- d ]thiazole-4,9-dione-based dyes as donors in additive manufacturing demonstrating their effectiveness in three different 3D printing technologies, i.e., direct laser writing (DLW), digital light processing (DLP), and liquid crystal display (LCD). These three-component formulations achieve high-precision 3D printed objects, with detailed characterization and comparison of the resulting structures.}, archive = {J_ANGEW}, author = {Ji Feng and Tong Gao and Fabrice Morlet-Savary and Michael Schmitt and Celine Dietlin and Jing Zhang and Xiaotong Peng and Pu Xiao and Frédéric Dumur and Jacques Lalevée}, doi = {10.1002/anie.202425198}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202425198}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Donor-π-acceptor photoinitiators for high-efficiency visible LED and sunlight polymerization and high-precision 3D printing}, volume = {64}, year = {2025}, }
• (2025). A biodegradable radical polymer enables high-performance, physically transient organic memory. ANGEW, 64(27), e202422826. (www)

  @article{ , abstract = {Electronic devices often demand high reliability and longevity, but they also contribute significantly to electronic waste. Physically transient electronics have thus emerged as a promising alternative in future electronics, particularly in wearable and implantable bioelectronics. In these applications, memristive materials have gained significant attention for their potential to realize neuromorphic systems that offer energy-efficient, hardware-based parallel processing. By integrating memristive capabilities with transient behavior, this study bridges these two cutting-edge fields, creating materials that not only enable advanced computing but also dissociate sustainably. Additionally, we leverage the unique features of soft materials for their tunability, biocompatibility, and cost-effectiveness, which collectively enhance this integration. In this work, we first illustrate molecular engineering strategy on a radical polymer. We then proceed to two-terminal devices therefrom, which exhibit exceptional memory performance of >10 6 on/off ratio, >10 4 s state retention, and stability over 250 DC sweep cycles. A flexible, optically transparent, and physically transient crossbar arrays are also developed, which maintain the performance through >3,000 bending cycles and fully dissociate in water at room temperature. This work represents an advancement toward a biorealistic platform with substantial multifunctionality, making it readily translatable to future wearable and implantable neuromorphic devices.}, archive = {J_ANGEW}, author = {Jaehyoung Ko and Soeun Kim and Daeun Kim and Taeho Lim and Soyeong Jin and Youngdo Jeong and Yongho Joo and Sangho Cho}, doi = {10.1002/anie.202422826}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202422826}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A biodegradable radical polymer enables high-performance, physically transient organic memory}, volume = {64}, year = {2025}, }
• (2025). Macrocyclic peptide probes for immunomodulatory protein CD59: Potent modulators of bacterial toxin activity and antibody-dependent cytotoxicity. ANGEW, 64(27), e202422673. (www)

  @article{ , abstract = {CD59 is an immunomodulatory cell surface receptor associated with human disease. Despite its importance in complement regulation and bacterial pathogenesis, CD59 remains a challenging therapeutic target. Research to date has focused on antibody or protein-based strategies. Here we present a new approach to target CD59 using macrocyclic peptides with low nanomolar affinity for CD59. Through X-ray crystallographic studies and structure-activity relationship (SAR) studies, we identify key interactions that are essential for binding and activity. We find that the macrocyclic peptide CP-06 adopts a beta-hairpin structure and binds CD59 through an intermolecular beta-sheet, mimicking protein–protein interactions of biologically relevant CD59 interaction partners. We create dimeric and lipidated macrocyclic peptide conjugates as enhanced cell-active CD59 inhibitors and show that these probes can be used to modulate both complement-mediated killing of human cells and lytic activity of bacterial virulence factors. Together, our data provide a starting point for future development of macrocyclic peptides to target CD59 activity in diverse cellular contexts.}, archive = {J_ANGEW}, author = {Jasmine K. Bickel and Ammar. I. S. Ahmed and Aidan B. Pidd and Rhodri M. Morgan and Tom E. McAllister and Sam Horrell and Emma C. Couves and Hemavathi Nagaraj and Edward J. Bartlett and Kamel El Omari and Akane Kawamura and Doryen Bubeck and Edward W. Tate}, doi = {10.1002/anie.202422673}, journal = {Angewandte Chemie International Edition}, month = {7}, number = {27}, pages = {e202422673}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Macrocyclic peptide probes for immunomodulatory protein CD59: Potent modulators of bacterial toxin activity and antibody-dependent cytotoxicity}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Surface chemistry of WC powder electrocatalysts probed in situ with NAP-XPS. ANGEW, 64(26), e202582602. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582602}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202582602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Surface chemistry of WC powder electrocatalysts probed in situ with NAP-XPS}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: A sustainable and scalable approach for in situ induction of gradient nucleation sites in biomass-derived interface layers for ultra-stable aqueous zinc metal batteries. ANGEW, 64(26), e202582601. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582601}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202582601}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: A sustainable and scalable approach for in situ induction of gradient nucleation sites in biomass-derived interface layers for ultra-stable aqueous zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: A single-molecule liposome assay for membrane permeabilisation (Angew. chem. int. ed. 26/2025). ANGEW, 64(26), e202512274. (www)

  @article{ , archive = {J_ANGEW}, author = {Krzysztof M. Bąk and Daniel C. Edwards and Dylan George and Bhanu Singh and Ryan Ferguson and Tianxiao Zhao and Kristin Piché and Ariel Louwrier and Scott L. Cockroft and Mathew H. Horrocks}, doi = {10.1002/anie.202512274}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202512274}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: A single-molecule liposome assay for membrane permeabilisation (Angew. chem. int. ed. 26/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Identification of an activity selector for the nitroso-forming activity in bacterial type-III copper enzymes (Angew. chem. int. ed. 26/2025). ANGEW, 64(26), e202512251. (www)

  @article{ , archive = {J_ANGEW}, author = {Hoa Le Xuan and Felix Panis and Annette Rompel}, doi = {10.1002/anie.202512251}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202512251}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Identification of an activity selector for the nitroso-forming activity in bacterial type-III copper enzymes (Angew. chem. int. ed. 26/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Photocatalytic nitrogen reduction for ammonia synthesis accelerated by overcoming photo-dember effect (Angew. chem. int. ed. 26/2025). ANGEW, 64(26), e202509838. (www)

  @article{ , archive = {J_ANGEW}, author = {Peishen Li and Yixuan Gao and Alistair G. L. Borthwick and Panpan Li and Huixuan Zhang and Fangyuan Chen and Long Chen and Fan Li and Wen Liu}, doi = {10.1002/anie.202509838}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202509838}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Photocatalytic nitrogen reduction for ammonia synthesis accelerated by overcoming photo-dember effect (Angew. chem. int. ed. 26/2025)}, volume = {64}, year = {2025}, }
• (2025). Front cover: Decoding double layer dynamics for CO2 electroreduction over cu (Angew. chem. int. ed. 26/2025). ANGEW, 64(26), e202509575. (www)

  @article{ , archive = {J_ANGEW}, author = {Daniel Sinausia and Noam Zisser and Thierry Kilian Slot and David Eisenberg and Florian Meirer and Charlotte Vogt}, doi = {10.1002/anie.202509575}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202509575}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Front cover: Decoding double layer dynamics for CO2 electroreduction over cu (Angew. chem. int. ed. 26/2025)}, volume = {64}, year = {2025}, }
• (2025). Mechanistic insights: Correspondence on “Tuning co-operative energy transfer in Copper(I) complexes using two-photon absorbing diimine-based ligand sensitizers”. ANGEW, 64(26), e202509203. (www)

  @article{ , abstract = {In a recent communication, Collins and coworkers presented a Cu(I) complex with photocatalytic activity under red light LED conditions, mainly for singlet oxygen-driven reactions. Guided by steady-state emission measurements with 800 nm excitation, the authors suggested that the underlying mechanism for the generation of the photoexcited key species is a simultaneous two-photon absorption via a virtual state. However, such a mechanism requires pulsed laser excitation and cannot compete when a conventional one-photon excitation is also feasible with the selected excitation wavelength range. Using several spectroscopic techniques and reactivity assays under different light color and intensity conditions, we unambiguously demonstrate that a conventional one-photon excitation followed by rather inefficient singlet oxygen generation (quantum yield <5%) is responsible for the observed photoreactivity of the Cu(I) complex. In addition, we briefly summarize general mechanistic considerations, estimate typical photon densities required for a variety of two-photon mechanisms, highlight the importance of optical filters and impurities to avoid artifacts in the emission spectra, and present some guidelines for the differentiation between one- and two-photon mechanisms.}, archive = {J_ANGEW}, author = {Julian A. Moghtader and Maria-Sophie Bertrams and Dieter Schollmeyer and Christoph Kerzig}, doi = {10.1002/anie.202509203}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202509203}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanistic insights: Correspondence on “Tuning co-operative energy transfer in Copper(I) complexes using two-photon absorbing diimine-based ligand sensitizers”}, volume = {64}, year = {2025}, }
• (2025). Mark c. lipke. ANGEW, 64(26), e202508938. (www)

  @article{ , archive = {J_ANGEW}, author = {Mark C. Lipke}, doi = {10.1002/anie.202508938}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202508938}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mark c. lipke}, volume = {64}, year = {2025}, }
• (2025). Caterina g. c. marques netto. ANGEW, 64(26), e202508876. (www)

  @article{ , archive = {J_ANGEW}, author = {Caterina G. C. Marques Netto}, doi = {10.1002/anie.202508876}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202508876}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Caterina g. c. marques netto}, volume = {64}, year = {2025}, }
• (2025). Correction to “High-connectivity 3D covalent organic frameworks with pdp net for efficient C2H2/CO2 separation”. ANGEW, 64(26), e202508353. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202508353}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202508353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “High-connectivity 3D covalent organic frameworks with pdp net for efficient C2H2/CO2 separation”}, volume = {64}, year = {2025}, }
• (2025). Correction to “Iridium(III) blue phosphors with heteroleptic carbene cyclometalates: Isomerization, emission tuning, and OLED fabrications”. ANGEW, 64(26), e202508263. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202508263}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202508263}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Iridium(III) blue phosphors with heteroleptic carbene cyclometalates: Isomerization, emission tuning, and OLED fabrications”}, volume = {64}, year = {2025}, }
• (2025). Coronal complexation induces snowman-shaped janus polymersome formation. ANGEW, 64(26), e202507756. (www)

  @article{ , abstract = {Engineering polymersome shape is a keen area of interest because minimal variations in polymersome properties can greatly affect the performance of nanoreactors, drug delivery vehicles, and more. Although methods to transform polymersome shapes have been evolving rapidly, limitations remain in the scope of applicable polymersome compositions and adaptability to engineer a desired shape. In this work, we developed a method utilizing cationic polymer additives and coronal complexation to transform charged spherical polymersomes into asymmetric Janus polymersomes. The resulting morphologies feature a hollow polymersome compartment conjoined to a protruding bleb consisting of the complexed polymer additive, which we propose forms via a dewetting process. This methodology provides enhanced shape control through adjustments in additive composition or plasticizer content, offering additional routes to engineering novel polymersome structures.}, archive = {J_ANGEW}, author = {Rebecca Y. Lai and Chin Ken Wong and Martina H. Stenzel}, doi = {10.1002/anie.202507756}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202507756}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coronal complexation induces snowman-shaped janus polymersome formation}, volume = {64}, year = {2025}, }
• (2025). Covalent adaptable networks mediated by redox-responsive neighboring-group-participating transalkylation. ANGEW, 64(26), e202507680. (www)

  @article{ , abstract = {Covalent adaptable networks (CANs) typically require external catalysts to facilitate efficient crosslinker exchange, which can limit the reprocessability of the network due to leaching and degradation of the catalyst. In this study, the use of catalysts was avoided by employing a bicyclo[3.3.1]nonane (BCN) bis-alkyl halide crosslinker with selenium-based neighboring-group-participation (NGP) to enhance the rate of bond exchange. This thermally mediated C─N alkyl exchange and the associated flow behavior enabled the intrinsically ionic network (which possesses antimicrobial properties) to be both chemically recycled and repaired and reprocessed under mild conditions. Furthermore, the dynamic behavior of the network can be regulated by the reversible redox responsiveness of selenium atoms within the network. This novel type of NGP-based CAN therefore has the potential to enrich designs for catalyst-free dynamic networks with high performance and modulated dynamicity.}, archive = {J_ANGEW}, author = {Wenyu Dong and Yuxin Luo and Junlu Zhang and Wenchao Zhang and Ningning Song and Min Xia and M. G. Finn and Zhishuai Geng}, doi = {10.1002/anie.202507680}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202507680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent adaptable networks mediated by redox-responsive neighboring-group-participating transalkylation}, volume = {64}, year = {2025}, }
• (2025). Exploring the interplay of lattice dynamics and charge transport in organic semiconductors: Progress toward rational phonon engineering. ANGEW, 64(26), e202507566. (www)

  @article{ , abstract = {Organic semiconductors (OSCs) have garnered significant attention due to their potential use in flexible, lightweight, and cost-effective electronic devices. Despite their promise, the assembly of organic molecules into the condensed phase promotes a diverse set of lattice dynamics that introduce a detrimental modulation in the intermolecular electronic structure—termed dynamic disorder—that results in charge carrier mobilities that are orders of magnitude lower than inorganic semiconductors. This dynamic disorder is generally associated with low-frequency phonons, yet whether a small subset of modes or a broad range of phonons  drives dynamic disorder remains contested. Resolving this debate is critical for defining how targeted phonon engineering could practically improve OSC performance. In this review, we explore progress toward uncovering the interplay between lattice dynamics and charge transport in OSCs, focusing on the critical role of thermally activated phonons. We describe the powerful insight that mode-resolved analyses of electron–phonon interactions lends toward the rational design of new materials. We highlight recent efforts to achieve this, showcasing proposed strategies to mitigate dynamic disorder through molecular and crystal design. This work offers an overview of the insight gained toward understanding the fundamental mechanisms governing charge transport in OSCs and outlines pathways for enhancing performance via targeted manipulation of interatomic/intermolecular interactions and resulting phonon modes.}, archive = {J_ANGEW}, author = {Barbara M. T. C. Peluzo and Rahul Meena and Luca Catalano and Guillaume Schweicher and Michael T. Ruggiero}, doi = {10.1002/anie.202507566}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202507566}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploring the interplay of lattice dynamics and charge transport in organic semiconductors: Progress toward rational phonon engineering}, volume = {64}, year = {2025}, }
• (2025). Sequence control in sulphur-containing ring-opening co- and terpolymerisations. ANGEW, 64(26), e202507243. (www)

  @article{ , abstract = {Sulphur-containing polymers uniquely expand the catalogue of accessible material properties compared to current commodity materials, yet their synthesis remains underdeveloped. Combining sulphur- and oxygen-containing monomers in ring-opening copolymerisation leads to a reshuffling reaction of the sulphur centres, which has been challenging to control — a central task for reliably tailoring properties. However, very recent methodologies have emerged that not only suppress but also utilise this phenomenon to precisely access sulphur-containing polymer structures. These structures can exhibit improved degradability, chemical recyclability, refractive indices and crystallinity compared to their all-oxygen analogues. Furthermore, underutilised and even entirely untapped monomer feedstocks can become accessible as a result. This minireview aims to provide a roadmap of the tools currently available to selectively access sulphur-containing co- and terpolymer structures to enable emerging applications that leverage the chemistry of sulphur.}, archive = {J_ANGEW}, author = {Bhargav R. Manjunatha and Cesare Gallizioli and Christoph Fornacon-Wood and Jenny Stephan and Merlin R. Stühler and Alex J. Plajer}, doi = {10.1002/anie.202507243}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202507243}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sequence control in sulphur-containing ring-opening co- and terpolymerisations}, volume = {64}, year = {2025}, }
• (2025). Solvent induced transformation of homoleptic alkynyl-protected large silver nanoclusters. ANGEW, 64(26), e202506971. (www)

  @article{ , abstract = {Structural transformation of high-nuclearity nanoclusters is of significant interest because of its relevance to the formation mechanisms and stability of metal clusters. Herein, we report three large homoleptic alkynyl-protected silver nanoclusters, [Ag 98 (2-CH 3 C 6 H 4 C≡C) 52 ](BF 4 ) 2 , [Ag 86 (2-CH 3 C 6 H 4 C≡C) 50 ](BF 4 ) 4 , and [Ag 74 (2-CH 3 C 6 H 4 C≡C) 44 ](BF 4 ) 2 , synthesized from the same precursor 2-CH 3 C 6 H 4 C≡CAg via fine-tuning the reduction rate. X-ray crystallography demonstrates that Ino decahedral Ag 13 units serve as building blocks in all three nanoclusters. Remarkably, Ag 98 undergoes an intercluster transformation in methanol. It initially converts into Ag 74 , then Ag 74 reacts with Ag 98 to form Ag 86 , which eventually is transformed into the thermodynamically stable Ag 74 . Time-dependent electrospray ionization mass spectrometry (ESI-MS) confirms such a multi-step reaction process during the transformation, identifying Ag 86 as the key intermediate. Our findings not only provide new insights into the structural transformation pathways of nanoclusters but also enhance the understanding of transformation mechanisms, contributing to the rational synthesis of high-nuclearity nanoclusters.}, archive = {J_ANGEW}, author = {Lu-Ming Zheng and Zhen-Chao Long and Feng Hu and Jiangtao Chan and Wan-Qi Shi and Ben Zhang and Zhaohui Wang and Quan-Ming Wang}, doi = {10.1002/anie.202506971}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506971}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent induced transformation of homoleptic alkynyl-protected large silver nanoclusters}, volume = {64}, year = {2025}, }
• (2025). Cooperative dinuclear gold catalysis unlocking 1,2-reductive elimination elementary reaction in oxidative C─C coupling. ANGEW, 64(26), e202506925. (www)

  @article{ , abstract = {Cooperative catalysis enabled by dinuclear metal complexes can integrate the catalytic properties of each metal center, thus opening new avenues to achieve challenging reaction selectivity that are difficult to accomplish with mononuclear metal catalysts. Here, we present a cooperative catalysis strategy using a newly synthesized dinuclear PNP-Au 2 catalyst, which positions two gold centers in close proximity, facilitating favorable geometric and electronic interactions for the synergistic activation of both coupling partners (alkynes and vinyl boron reagents) in the oxidative C─C coupling. It demonstrates a broad substrate tolerance for both terminal and internal alkynes, providing a versatile platform for the synthesis of enynes and dienes. Mechanistic and computational studies reveal a unique 1,2-cooperative activation mode, significantly reducing the free energy barrier and stabilizing the key intermediates, thus promoting C─C bond formation in an efficient manner. The DFT calculations indicate a less explored 1,2-reductive elimination elementary step. Interestingly, the use of B(O i Pr) 3 as an additive can effectively prevent the decomposition of dinuclear gold catalyst under oxidative fluoride-containing conditions.}, archive = {J_ANGEW}, author = {Shangwen Fang and Yu Liu and Fei Wang and Yue Zhao and Congqing Zhu and Yuncong Chen and Sergey N. Konchenko and Jing Zhao and Jie Han and Jin Xie}, doi = {10.1002/anie.202506925}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506925}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative dinuclear gold catalysis unlocking 1,2-reductive elimination elementary reaction in oxidative C─C coupling}, volume = {64}, year = {2025}, }
• (2025). Solvent-driven interconversion of pyridine dicarbanion-bonded ag13 nanocluster isomers. ANGEW, 64(26), e202506860. (www)

  @article{ , abstract = {Solvent screening is pivotal for optimizing metal-catalyzed reactions, yet its impact on the in situ formation and reactivity of polynuclear organometallic clusters remains underexplored. We herein isolate two distinct thirteen-membered silver cluster isomers, Ag 13 -A and Ag 13 -M , in acetone and methanol, respectively. Significantly, we demonstrate the interconversion of these isomers facilitated by solvent manipulation. Mechanistic studies on the solvent-driven Ag 13 -A to Ag 13 -M transformation reveal this transformation proceeds with a low activation energy (23.39 ± 0.81 kcal mol −1 ) and positive entropy, involving counter anion dissociation, ligand twisting, and re-coordination. The observed differences in thermal stability and reactivity between two isomers are attributed to variations in Ag–Ag interactions and surface ligand arrangements, underscoring the critical role of solvent selection in affecting the whole organic transformation through in situ formed clusters. These results highlight the necessity of considering organometallic cluster intermediates in solvent screening.}, archive = {J_ANGEW}, author = {Cong Jin and Cui-Cui Li and Kui Xiao and Wan Wang and Songshan Dai and Qianqian Deng and Keting Zhou and Yu Xia and Jun Zhu and Liang Zhao}, doi = {10.1002/anie.202506860}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506860}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-driven interconversion of pyridine dicarbanion-bonded ag13 nanocluster isomers}, volume = {64}, year = {2025}, }
• (2025). The mechanism of ruthenium-catalyzed directed C─H arylation of arenes: The key role of bis-cyclometalated intermediates. ANGEW, 64(26), e202506707. (www)

  @article{ , abstract = {The mechanism of Ru-catalyzed N -directed C-H ortho -arylation with haloarenes has been under intense scrutiny over the last decade, with conflicting proposals concerning the relevance of various catalytic intermediates and the nature of the key steps. This work presents experimental and computational studies that address these long-standing questions. Stoichiometric, catalytic, and mechanistic kinetic studies, supported by DFT calculations, reveal that bis-cyclometallated ruthenium species are key intermediates in these reactions. These studies also show that oxidative addition with bromoarenes proceeds via a concerted oxidative addition pathway, as demonstrated by DFT and experimental kinetic orders. Bromoarene activation does not proceed at mono-cyclometalated species. In the catalytic process, zero order kinetics are observed on both reaction substrates, an observation that is rationalized by DFT calculations which predict a rate-limiting step within the product-release stage. These results showcase how detailed experimental and DFT studies can combine to probe mechanistic questions, as well as resolving opposing views around the mechanism of these Ru-catalyzed arylations that form the basis of promising mild C─H functionalizations.}, archive = {J_ANGEW}, author = {Pablo Domingo-Legarda and Samuel E. Neale and Ambre Carpentier and Claire L. McMullin and Michael Findlay and Igor Larrosa and Stuart A. Macgregor}, doi = {10.1002/anie.202506707}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The mechanism of ruthenium-catalyzed directed C─H arylation of arenes: The key role of bis-cyclometalated intermediates}, volume = {64}, year = {2025}, }
• (2025). Fused dual-donor design for accelerating reverse intersystem crossing rates of spatially folded through-space charge transfer emitters. ANGEW, 64(26), e202506654. (www)

  @article{ , abstract = {The development of through-space charge transfer (TSCT)-thermally activated delayed fluorescence (TADF) material is defective in relatively low reverse intersystem crossing (RISC) rates (commonly <5 × 10 5 s −1 ). Herein, we fuse two 3,6-dimethyl-8H-indolo[3,2,1- de ]acridine (IAc) donor units to obtain large planar donors ( m -bIAc and p -bIAc) for forming spatially folded A–D|D–A configured TSCT emitters (DCT-1 and DCT-2). The configuration of highly parallel and large-plane intramolecular multiple π-stacking has been achieved. The symmetrical multi-channel charge transfer networks of emitters induce multiple energetically proximal excited states within a small energy range (<0.12 eV) at the lowest excited state, creating additional configuration interaction and spin-orbit coupling channels to accelerate the RISC process. This molecular configuration yields enhanced RISC rates of 6.19 × 10 5 s −1 for DCT-1 and 1.05 × 10 6 s −1 for DCT-2. Solution-processed organic light-emitting diodes employing these emitters achieve maximum external quantum efficiencies of 18.9% (DCT-1, 474 nm sky-blue emission) and 23.9% (DCT-2, 498 nm green emission), with attenuated efficiency roll-offs of DCT-2 (12% at 1000 cd m −2 ). This work provides a critical pathway for manipulating dense excited states to address the bottleneck of the RISC rates while maintaining structural rigidity, promoting further advancement of TSCT-TADF materials.}, archive = {J_ANGEW}, author = {Quanwei Li and Haisong Zhao and Maoqiu Li and Yuchao Liu and Shouke Yan and Zhongjie Ren}, doi = {10.1002/anie.202506654}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fused dual-donor design for accelerating reverse intersystem crossing rates of spatially folded through-space charge transfer emitters}, volume = {64}, year = {2025}, }
• (2025). S-vacancy-induced “Proton fence effect” enables selectivity switching between CH4 and CO in photo-assisted CO2 electroreduction. ANGEW, 64(26), e202506608. (www)

  @article{ , abstract = {Upcycling CO 2 into high-value C 1 products is impressive for achieving carbon neutrality and energy sustainability, while rational modulation of C 1 product selectivity is one of the biggest challenges in electrocatalytic CO 2 reduction reaction (eCO 2 RR) due to the competing reaction pathways and thermodynamic limitation. Here, we showcase a “proton fence” strategy enabled by in situ adsorbed *OH on sulfur vacancies (S V ) to ultraselectively switch the C 1 product between CH 4 and CO during CO 2 RR, with Faraday efficiency of 93.6% and 95.3%, respectively. In situ measurements uncover that the photo-generated holes counteract Cu 2+ electroreduction to retain the intact structure of CuInS 2 /CuS, while *OH dissociated from water can spontaneously anchor toward S V to hinder the local proton migration, completely circumventing multiproton products. Meanwhile, the preferential desorption of *CO from Cu centers adjacent to the *OH-anchored S V renders the exclusive formation of CO. In the absence of S V , *CO can be further hydrogenated in a lower free energy/even spontaneously to afford CH 4 . The proposed proton confinement effect furnishes a promising reference for the selectivity control of eCO 2 RR, and the photo-assisted electroreductive protocol demonstrates a paradigm of in situ stabilization of electron-intolerant catalytic structures.}, archive = {J_ANGEW}, author = {Shengqi Liu and Zhenyan Guo and Zhengyi Li and Song Yang and Dingsheng Wang and Hu Li}, doi = {10.1002/anie.202506608}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {S-vacancy-induced “Proton fence effect” enables selectivity switching between CH4 and CO in photo-assisted CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Synergistic C─N coupling for efficient cyclohexanone oxime synthesis from ambient air by supported molecular catalysts. ANGEW, 64(26), e202506546. (www)

  @article{ , abstract = {Electrocatalytic synthesis of cyclohexanone oxime from rich nitrogen resources is a promising alternative to traditional industrial processes. However, the difficulties in unraveling atomic-scale catalytic mechanisms and managing selective C─N coupling still pose great challenges to realizing considerable yield and selectivity, and therefore rational catalyst design to boost collaborative C─N coupling for oxime synthesis is particularly attractive. In the present work, molecular catalysts are demonstrated to be unique for oxime synthesis under mild conditions, i.e., iron bis(pyridyl)amine-bipyridine (FeBPAbipyH) modified MWCNTs@CP (multi-walled carbon nanotubes coated carbon fiber paper) cathodes produced cyclohexanone oxime from NO 2 − and cyclohexanone, attaining mass-specific efficiency of 87.00 mg h −1 cm −2 mg cat −1 , Faradaic efficiency (FE) of 77.3%, and exclusive carbon selectivity, which is the best efficiency known to date in H-cell. Mechanistic studies showed that the FeBPAbipyH molecular skeleton exhibited intimate interaction with both cyclohexanone and NO 2 − , and catalyzed selective NO 2 − -to-NH 2 OH reduction for C─N bond in situ. The in-depth understanding of substrate-catalyst interactions and synergic C─N coupling from molecular points of view offers valuable insights to boost collaborative synthesis of organic nitrogen compounds. Further integrating plasma-driven N 2 oxidation and electrocatalysis enabled cyclohexanone oxime formation at 61.73 mg h −1 cm −2 mg cat −1 on the FeBPAbipyH/MWCNTs@CP electrode, and the whole synthetic and separation process is projected to be profitable with a promising cost of $2709 ton −1 , which is much lower than the breakeven point (∼$10 000 ton −1 ), representing a sustainable pathway to nitrogenous chemical synthesis from abundant resources under ambient conditions.}, archive = {J_ANGEW}, author = {Chen Zhang and Shu-Lin Meng and Yan-Nan Jing and Cheng Wang and Xin-Ling Zhang and Hai-Xu Wang and Chen-Ho Tung and Li-Zhu Wu}, doi = {10.1002/anie.202506546}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506546}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic C─N coupling for efficient cyclohexanone oxime synthesis from ambient air by supported molecular catalysts}, volume = {64}, year = {2025}, }
• (2025). Robust tunnel TaOx passivating interlayer enables long-term solar water oxidation. ANGEW, 64(26), e202506326. (www)

  @article{ , abstract = {Silicon-based photoelectrochemical (PEC) cells offer significant advantages for solar-to-clean fuel conversion but face challenges such as surface recombination and poor stability, necessitating a comprehensive understanding of device failure mechanisms and effective mitigation strategies. Using nickel-decorated n-type silicon (n-Si/Ni) as a model photoelectrode, we demonstrate that surface restructuring during operation initially passivates surface recombination but eventually blocks photogenerated hole transfer, leading to device failure. To mitigate this challenge, an ultrathin (<1 nm) tantalum oxide (TaO x ) interlayer is introduced via atomic layer deposition (ALD). This TaO x layer serves as both a passivating contact and a corrosion-resistant coating. The n-Si/TaO x /Ni electrode achieves an increased photovoltage from 150 to 500 mV during the activation process, and then significantly extends the device lifespan, maintaining over 90% performance for 500 h in 1 M KOH at 1.52 V versus RHE. These results highlight the implementation of amorphous TaO x in enhancing both the efficiency and durability of silicon-based PEC systems, providing a simultaneously passivating and protective strategy for solar-to-fuel conversion technologies under harsh conditions.}, archive = {J_ANGEW}, author = {Yuanqi Wang and Yinglei Zhu and Lijuan Zhang and Huiting Huang and Changhao Liu and Bin Gao and Wangxi Liu and Huihui Yan and Jingrui Jian and Zengguang Huang and Jianyong Feng and Tao Yu and Zhigang Zou and Zhaosheng Li}, doi = {10.1002/anie.202506326}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506326}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust tunnel TaOx passivating interlayer enables long-term solar water oxidation}, volume = {64}, year = {2025}, }
• (2025). Stable mg2+ dication weakly Stabilized/Coordinated in solution: Synthesis, structure, reactivity, and use in catalysis. ANGEW, 64(26), e202506266. (www)

  @article{ , abstract = {The first soluble and stable Mg 2+ dication stabilized only by weakly coordinating and chemically robust carborate anions [HexCB 11 Cl 11 ] − is described. Mg[HexCB 11 Cl 11 ] 2 ( 1 ), prepared by reaction of Mg( n Bu) 2 with 2 equiv of [Ph 3 C][HexCB 11 Cl 11 ], consists, in the solid state, of a central Mg 2+ surrounded by two [HexCB 11 Cl 11 ] − anions. In solution, experimental and classical molecular dynamics simulations (cMD) agree with cation/anion association being retained, reflecting the high electrophilicity of the Mg center. Yet, reflecting only weak anion/cation interactions, species 1 polymerizes 1-hexene and coordinates alkynes. However, 1 displays no reaction with HSiEt 3 at room temperature, consistent with a low hydridicity of the hard (HSAB) Mg 2+ center. Contrasting with 1 (FIA = 264 kJ mol −1 ; FIA: Fluoride Ion Affinity), salt Mg[( n Bu) 3 NB 12 H 4 Cl 7 ] 2 ( 2 ), incorporating the more basic ammoniododecaborate [( n Bu) 3 NB 12 H 4 Cl 7 ] − anion, is significantly less Lewis acidic (FIA = 214.7 kJ mol −1 ) and unreactive with alkenes and alkynes. Salt 1 effectively catalyzes alkene/alkyne hydrosilylation via an initial alkene/alkyne coordination/initiation, as suggested by experimental and computational data. It also efficiently catalyzes (with a catalyst loading down to 0.1 mol%) the hydrosilylation of CO 2 to CH 4 in the presence of HSiEt 3 . Salt 1 smoothly promotes the catalytic transfer hydrogenation of 1,1-diphenylethylene, and it is also an active imine hydrogenation catalyst in the presence of H 2 .}, archive = {J_ANGEW}, author = {Xuejuan Xu and Alain Chaumont and Christophe Gourlaouen and Satawat Tongdee and Sandip Munshi and Béatrice Jacques and Rudolf Wehmschulte and Samuel Dagorne}, doi = {10.1002/anie.202506266}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506266}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable mg2+ dication weakly Stabilized/Coordinated in solution: Synthesis, structure, reactivity, and use in catalysis}, volume = {64}, year = {2025}, }
• (2025). Day-long organic persistent luminescence in flexible polymeric materials. ANGEW, 64(26), e202506261. (www)

  @article{ , abstract = {The progress in organic afterglow materials has drawn significant attention due to their extensive applications in fields such as optoelectronics, anti-counterfeiting, and bioimaging. Nonetheless, a general limitation of organic afterglow materials is their short emission lifetimes, typically spanning from milliseconds to seconds, which creates a substantial challenge in developing day-long organic afterglow (DOA). In this study, a DOA system is demonstrated through the incorporation of electron donor/acceptor exciplexes. Polyethylene naphthalate is used for both the electron acceptor and charge storage units, coupling with a spirobifluorene-carbazole derivative as the electron donor, providing effective charge separations under UV-light and sunlight excitation. The resulting DOA polymers demonstrate an exceptional bluish-green afterglow that endures for over 28 h under ambient conditions, setting a new record for the longest afterglow duration in polymeric materials. Moreover, the DOA-doped polymers, as both films and fibers, exhibit outstanding flexibility and transparency, making them highly suitable for flexible technologies and wearable devices.}, archive = {J_ANGEW}, author = {Longming Jin and Wanqi Mo and Ziyi Wang and Wei Hong}, doi = {10.1002/anie.202506261}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506261}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Day-long organic persistent luminescence in flexible polymeric materials}, volume = {64}, year = {2025}, }
• (2025). Catalytic enantioselective reductive arylation and alkenylation of sulfinylamines to access sulfinamides enabled by cobalt catalysis. ANGEW, 64(26), e202506243. (www)

  @article{ , abstract = {This study reports a cobalt-catalyzed method for the enantioselective reductive arylation and alkenylation of sulfinylamines, facilitating the efficient synthesis of enantiopure sulfinamides. By employing a cobalt/chiral diphosphine and tridentate ligand system, a range of diverse aryl and alkenyl iodides were successfully transformed into sulfinamides, achieving high yields and excellent enantioselectivity. This methodology underscores the utility of sulfinylamines as versatile electrophilic sulfur sources. Detailed mechanistic insights from density functional theory (DFT) calculations suggest that the key step involves migratory insertion into the sulfilimine group, which plays a crucial role in enantioselectivity. These findings offer a sustainable approach for the development of biologically relative enantiopure sulfur-containing compounds.}, archive = {J_ANGEW}, author = {Yin Yuan and Xinyu Tian and Hongxia Zheng and Yuze Li and Junliang Zhang and Junfeng Yang}, doi = {10.1002/anie.202506243}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506243}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic enantioselective reductive arylation and alkenylation of sulfinylamines to access sulfinamides enabled by cobalt catalysis}, volume = {64}, year = {2025}, }
• (2025). Desulfurizative fluorination of N-CF3 thioformamides for the efficient synthesis of N(CF3)(CF2H) amines with enhanced stability. ANGEW, 64(26), e202506154. (www)

  @article{ , abstract = {With poor metabolic stability being a major cause of failure in drug development, there is a pressing need for strategic molecular modifications to optimize for desired properties and function. N -substitution has emerged as a powerful approach, with N -CF 3 amines previously demonstrating enhanced lipophilicity and reduced susceptibility to oxidation, albeit inherent instability to hydrolysis. This report discloses the further evolution of this motif—the introduction of an additional N -difluoromethyl unit, resulting in an extraordinary 2000-fold increase in stability. We present the first general synthetic strategy for accessing N (CF 3 )(CF 2 H) amines. The method relies on an operationally simple desulfurization–fluorination strategy of N -CF 3 thioformamides and is characterized by broad functional group tolerance.}, archive = {J_ANGEW}, author = {Gina Wycich and Jaime Ponce-de-León and Linhao Liu and Franziska Schoenebeck}, doi = {10.1002/anie.202506154}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506154}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Desulfurizative fluorination of N-CF3 thioformamides for the efficient synthesis of N(CF3)(CF2H) amines with enhanced stability}, volume = {64}, year = {2025}, }
• (2025). Catalytic enantioselective α-ethynylation of oxindoles: Total synthesis of (-)-corynoxine, (-)-isorhynchophylline, (-)-aspidospermidine, and (-)-limaspermidine. ANGEW, 64(26), e202506065. (www)

  @article{ , abstract = {The all-carbon quaternary stereogenic center of oxindoles is a crucial structural element of a broad spectrum of indole alkaloids, imparting these molecules with rigid three-dimensional configurations essential for their biological activities. Here, we present a catalytic asymmetric α-ethynylation reaction of oxindoles taking advantage of the catalysis of a spiropyrrolidine amide (SPA) triazolium. This transformation enables the enantioselective construction of the C3 quaternary carbon stereocenter of oxindoles while introducing a versatile ethynyl functionality. Employment of this methodology has been demonstrated in the divergent total synthesis of indole alkaloids (-)-corynoxine, (-)-isorhynchophylline, (-)-aspidospermidine, and (-)-limaspermidine, featuring a protecting group-dependent 1,6-Michael addition or an aminolysis/1,6-Michael addition sequence to generate two distinct types of spiro-indoles, tailored for different late-stage synthetic purposes.}, archive = {J_ANGEW}, author = {Bao-Kuan Guo and Yu-Dong Zhang and Ju-Song Yang and Jin-Rui Tian and Xiao-Ming Zhang and Fu-Min Zhang and Yong-Qiang Tu}, doi = {10.1002/anie.202506065}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506065}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic enantioselective α-ethynylation of oxindoles: Total synthesis of (-)-corynoxine, (-)-isorhynchophylline, (-)-aspidospermidine, and (-)-limaspermidine}, volume = {64}, year = {2025}, }
• (2025). Self-photosensitizing cobalt complexes for photocatalytic CO2 reduction coupled with CH3OH oxidation. ANGEW, 64(26), e202506060. (www)

  @article{ , abstract = {The use of metal complexes as homogeneous molecular catalysts has attracted considerable attention regarding photocatalytic CO 2 reduction. Enhancing these complexes with photosensitivity and photooxidation capabilities, aiming to create multifunctional molecular devices, presents significant challenges. In response to these challenges, we successfully designed and synthesized three innovative metal complexes. The complexes demonstrate a remarkable ability to perform CO 2 photoreduction in tandem with methanol photooxidation, allowing for the simultaneous production of formic acid without requiring additional photosensitizers and electron sacrificial reductants. An optimal turnover number (TON) value of 855 was obtained under simulated sunlight. Even under natural sunlight, the TON can reach 207, much higher than the value of the physical mixture of the photocatalytic reductive and oxidative moieties. Spectroscopic studies and density functional theory (DFT) calculations revealed that integrating reduction and oxidation sites in one molecular catalyst can promote charge transfer kinetics and enhance activity for CO 2 reduction and methanol oxidation. This is the first report that non-noble metal homogeneous catalysts can simultaneously possess photosensitivity, photoreduction, and photo-oxidation functions, offering new insights into designing homogeneous catalysts for artificial photosynthesis.}, archive = {J_ANGEW}, author = {Ji-Hong Zhang and Zhao-Ming Ge and Di-Chang Zhong and Jing-Lin Zuo and Marc Robert and Tong-Bu Lu}, doi = {10.1002/anie.202506060}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202506060}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-photosensitizing cobalt complexes for photocatalytic CO2 reduction coupled with CH3OH oxidation}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed asymmetric cyanation of propargylic radicals derived from silyl-substituted allenes and alkynes. ANGEW, 64(26), e202505939. (www)

  @article{ , abstract = {Here, we report an efficient method to synthesize enantiomerically enriched propargyl nitriles via copper-catalyzed asymmetric cyanation of propargylic radicals, which are generated from silyl-substituted allenes or alkynes. These reactions proceeded through a highly site-selective hydrogen atom abstraction (HAA) with Cu(II)-bound nitrogen-centered radicals (NCRs). Notably, silyl-substituted allenes demonstrate exceptional allenic sp 2 C─H bond activation selectivity, outcompeting alternative reactive sp 3 C─H bonds (benzylic, allylic, and heteroatom-adjacent) in HAA processes. This chemo-selectivity profile enables precise enantiocontrol and site-specific functionalization of complex molecular architectures.}, archive = {J_ANGEW}, author = {Zhongming Cheng and Guoyu Zhang and Yunshun Deng and Yiping Zhang and Xiang Li and Pinhong Chen and Guosheng Liu}, doi = {10.1002/anie.202505939}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505939}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed asymmetric cyanation of propargylic radicals derived from silyl-substituted allenes and alkynes}, volume = {64}, year = {2025}, }
• (2025). Scalable and ultrathin dual entangled network polymer electrolytes for safe solid-state sodium batteries. ANGEW, 64(26), e202505938. (www)

  @article{ , abstract = {Identifying ultrathin and flexible solid-state electrolytes with high ionic conductivity and low interfacial resistance is crucial for scale-up production of solid-state sodium (Na) metal batteries (SSMBs). However, the challenges of poor processing scalability, insufficient intrinsic mechanical strength, and limited ionic transport capacity remain unaddressed. Herein, an ultrathin 9.7 µm solid-state electrolyte membrane featuring a dual-polymer entangled network is meticulously engineered through an arrayed multi-nozzle electrospinning technique with a swelling and hot pressing process using polyacrylonitrile and poly(ether-block-amide), which exhibits an exceptional voltage tolerance, enhanced tensile strength, and superior thermal stability. The soft ether oxygens segments in multiblock copolymers complex with Na + to promote the rapid hopping transport of Na + . Meanwhile, interconnected electronegative channels based on carbonyl and cyanogen groups serve as Na + conduits to smooth ion fluctuations and accelerate Na + selective conduction simultaneously. The obtained inorganic-organic composite solid electrolyte interface with the improved mechanical strength of ultrathin solid-state electrolytes effectively suppresses Na dendrites with low overpotential over 500 h. The solid-state cells paired with layered oxides deliver a capacity retention of over 91.1% between 25 °C and 65 °C, and assembled pouch cells exhibit impressive energy density over 100 cycles, showing great potential for large-scale application of ultrathin structure in the SSMBs.}, archive = {J_ANGEW}, author = {Congcong Liu and Shufeng Jia and Tingzhou Yang and Jiabing Liu and Xinrui Zhou and Zhifeng Wang and Haochen Dong and Zhenjia Shi and Yongguang Zhang and Zhongwei Chen}, doi = {10.1002/anie.202505938}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505938}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable and ultrathin dual entangled network polymer electrolytes for safe solid-state sodium batteries}, volume = {64}, year = {2025}, }
• (2025). Isomerisation and insertion chemistry of imidosilanes enabled by reversible Si(IV)/Si(II) redox shuttling. ANGEW, 64(26), e202505872. (www)

  @article{ , abstract = {Spontaneous redox shuttling at silicon is very rare, primarily reflecting the thermodynamic challenges associated with reduction processes for lighter p -block elements. Here we show that the reactions of boryl-substituted silylene {PhC( t BuN) 2 }Si{B(NDippCH) 2 } with an organo-azide proceed through a Si(IV)-Si(II)-Si(IV) series of redox processes involving both oxidative and reductive ligand migration steps. Each of the isomeric compounds related through this reaction manifold is isolable (and can be structurally characterised by X-ray crystallography), with the overall free energy profile being close to thermo-neutral. Broader studies within group 14 imply that this redox shuttling is unique to silicon and that reductive ligand migration also plays a role in O-atom insertion chemistry.}, archive = {J_ANGEW}, author = {Jianqin Tang and Yuwen Wang and Agamemnon E. Crumpton and Caitilín McManus and Simon Aldridge}, doi = {10.1002/anie.202505872}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isomerisation and insertion chemistry of imidosilanes enabled by reversible Si(IV)/Si(II) redox shuttling}, volume = {64}, year = {2025}, }
• (2025). Ordered co-assembly of soft-in-hard hetero-structured pulse guidance ion-accelerator for dendrite-free aqueous zinc-ion battery anodes. ANGEW, 64(26), e202505855. (www)

  @article{ , abstract = {Constructing a solid electrolyte interface (SEI) layer to suppress dendrite growth is an effective approach in Zn-based aqueous batteries. Traditional SEI layers are limited by their simple structure and composition, enabling only one functionality of either providing nucleation sites or facilitating desolvation. In this study, a pulse guidance ion-accelerator is constructed by kinetics-controlled co-assembly of zincophilic micelles and zincophobic metal-organic framework (MOF). The closely packed soft micelles, in conjunction with the hard MOF host particles, form a multi-tiered soft-in-hard hetero-structure that accelerates adsorption, pre-desolvation, and subsequent desolvation processes, facilitating the (002) crystal plane dendrite-free deposition. As a result, stable cycling over 1900 h (31 mV polarization) in symmetric cell and 5200 cycles in the Zn//Cu battery (99.8% coulombic efficiency) can be achieved. These findings will effectively promote the development of stable and long-cycling aqueous zinc-ion batteries.}, archive = {J_ANGEW}, author = {Xiang Li and Jiahao Chen and Tong Wang and Binhang Wang and Yujie Cao and Dongliang Chao and Yun Tang}, doi = {10.1002/anie.202505855}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505855}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ordered co-assembly of soft-in-hard hetero-structured pulse guidance ion-accelerator for dendrite-free aqueous zinc-ion battery anodes}, volume = {64}, year = {2025}, }
• (2025). Asymmetric electrochemical alkenylation by synergistic chiral primary amine and naphthalene catalysis. ANGEW, 64(26), e202505826. (www)

  @article{ , abstract = {External tuning of enamine intermediate has significantly expanded reaction space of typical aminocatalysis. Notwithstanding the progress of chemo- and photo-oxidation of enamine intermediate, electro-oxidation was left as a much less explored area, in stark contrast to the prosperous renaissance of electrochemistry in recent years. Challenges mainly come from the reactivity barrier as a consequence of heterogeneous electron transfer and subtle stereocontrol in ionic electrolyte solution under the influence of electric field. Herein, we report asymmetric α-alkenylation of carbonyl compounds using potassium alkenyl trifluoroborate as a model reaction to demonstrate the capability of primary amine catalysis under electrochemical conditions. By employing enamine redox mediator mapping (e-RM 2 ) strategy, a new organic mediator, dimethoxyl naphthalene, was found to greatly enhance reactivity. Mechanistic studies uncover an ion-pair interaction between protonated aminocatalyst and anionic substrate that accounts for the exceptional enantioselectivity. This catalytic system demonstrates the best level of enantioselectivities in electro-oxidative enamine transformations so far.}, archive = {J_ANGEW}, author = {Yingdong Duan and Yuchen Zhang and Jianyuan Chen and Fanzhu Zeng and Liang Cheng and Sanzhong Luo}, doi = {10.1002/anie.202505826}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505826}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric electrochemical alkenylation by synergistic chiral primary amine and naphthalene catalysis}, volume = {64}, year = {2025}, }
• (2025). Concise enantioselective total syntheses of rearranged ent-trachylobane diterpenoids (–)-wallichanols a and b. ANGEW, 64(26), e202505766. (www)

  @article{ , abstract = {Herein, we report the first enantioselective total syntheses of three rearranged ent -trachylobane diterpenoids, (–)-Wallichanol A ( 1 ), (–)-Wallichanol B ( 2 ), and (–)-Sanguinolane ( 3 ), using a 13, 17, and 14 step longest-linear sequences respectively, featuring a novel intramolecular [2 + 2] cycloaddition to construct the unique pentacyclic framework containing an unprecedented tricyclo[3.3.1.0 2,7 ]nonane motif. Other key steps in the synthetic route include a highly challenging, selective alkene reduction via hydrogen atom transfer (HAT), leveraging the thermodynamic preference for a tertiary carbon-centered radical; a Robinson-type annulation to construct the tricyclic terpenoid building block; and applying aerobic oxidation at two distinct points to form α -hydroxy ketones, facilitating the enantioselective syntheses of these diterpenoids.}, archive = {J_ANGEW}, author = {Dattatraya H. Dethe and Nitin Sharma and Sakshi Juyal}, doi = {10.1002/anie.202505766}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505766}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concise enantioselective total syntheses of rearranged ent-trachylobane diterpenoids (–)-wallichanols a and b}, volume = {64}, year = {2025}, }
• (2025). Precise engineering of asymmetric tri-active sites by symbiotic strategy for photocontrolled directional reforming of biomass. ANGEW, 64(26), e202505718. (www)

  @article{ , abstract = {Sunlight-driven production of high-value chemicals from renewable resources represents a pivotal driver toward achieving sustainable energy supply. However, fundamental barriers include inadequate use of light energy and insufficient understanding of reactive oxygen species (ROS) regulating mechanisms in photocatalytic processes. To address this, a novel symbiotic strategy for the design of Cu x /TiO 2 single-atom catalysts (SACs) supported by density functional theory (DFT) calculations was proposed. The developed catalyst achieved nearly 100% conversion and selectivity for the directional photooxidative transformation of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran (DFF) or 2,5-furandicarboxylic acid (FDCA) under both vis-light and UV–vis light conditions. Importantly, compared to previous works, this catalyst exhibited the highest photooxidation activity reported to date while effectively suppressing the over-oxidation of HMF to CO 2 . Mechanistic investigations revealed that rational construction of Cu single-atoms (SAs) could effectively create the asymmetric Cu–Ov–Ti structure, which significantly enhanced the activation of O 2 and HMF, facilitating generation of oxygen vacancy (Ov) and Ti 3+ . Furthermore, Cu SAs served as hole (h + ) extractors in the photooxidation process, promoting rapid charge carrier transfer and ROS formation. The applicability of this developed strategy was further demonstrated for photooxidative conversion of various bio-feedstocks, including HMF and alcoholic substrates, indicating its great potential for harnessing light energy for sustainable valorization of biomass into high-value chemicals.}, archive = {J_ANGEW}, author = {Qiong Yan and Yang Chen and Bing Tang and Xu Wu and Heng Zhou and Hao Wang and Hui Li and Lanlu Lu and Heng Zhang and Song Yang and Chunbao Xu and Tianyi Ma}, doi = {10.1002/anie.202505718}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505718}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise engineering of asymmetric tri-active sites by symbiotic strategy for photocontrolled directional reforming of biomass}, volume = {64}, year = {2025}, }
• (2025). Unveiling an in situ H2O2 production: Rechargeable zinc-H2O2 battery powering 26 LEDs. ANGEW, 64(26), e202505593. (www)

  @article{ , abstract = {Looking toward ever-growing energy demand, the advancement in energy storage devices and carrying out electrocatalytic reactions in an efficient way is the need of the hour. Herein, we have employed the two birds-one stone approach, viz. fusing energy conversion and storing system enabling 2e − oxygen reduction reaction (ORR) to value-added hydrogen peroxide (H 2 O 2 ) product and its utilization in the energy storage devices using MnWO 4 catalyst, without any external H 2 O 2 source. The designed catalyst exhibited a remarkable H 2 O 2 production of 98% @ 0.37 V versus RHE. The real-time H 2 O 2 production was monitored by in-situ electrochemical Raman and in-situ infrared spectroscopic measurements. The pivotal influence of electrolyte composition, viz. local pH and the formation of carbonate species on H₂O₂ production was meticulously examined through micro-electrochemical studies using gold (Au) microelectrodes. Further, we have explored an aqueous rechargeable Zn-H 2 O 2 battery utilizing MnWO 4 as bifunctional electrocatalyst for sustainable H 2 O 2 production simultaneously producing the electricity. The Zn-H 2 O 2 battery exhibited a remarkable cycle life of 136 h and an practical energy efficiency of 43%. The galvanostatic charge–discharge measurement of Zn-H 2 O 2 battery attained a capacity of 25 mAh cm −2 at 3 mA cm −2 . The battery also demonstrated ≥90% cycle efficiency. Interestingly, the designed Zn-H 2 O 2 battery (two connected in series) exhibited a stable open circuit voltage (OCV) with a promising power density of 10.5 mW cm −2 . As a proof of concept, we have demonstrated Zn-H 2 O 2 batteries by powering 26 blue LEDs for more than 180 h (7 days) without fading in the illumination of LEDs.}, archive = {J_ANGEW}, author = {Shivangi Mehta and Sukhjot Kaur and Kalpana Garg and Man Singh and Tharamani C. Nagaiah}, doi = {10.1002/anie.202505593}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling an in situ H2O2 production: Rechargeable zinc-H2O2 battery powering 26 LEDs}, volume = {64}, year = {2025}, }
• (2025). Constructions of biaryl-bridged macrocycles through phosphine-ligand-controlled switch of selectivity between intra- and intermolecular cyclizations. ANGEW, 64(26), e202505591. (www)

  @article{ , abstract = {The rigid biaryl-bridged macrocycles serve as core scaffolds in numerous bioactive molecules. However, constructing biaryl-bridged macrocycles smaller than 14-membered ring remains challenging, partially due to the strain present in the cyclic intermediates formed during their synthesis. Here, we report that a Pd catalyst supported by P( t Bu) 3 effectively promotes the intramolecular ortho C─H arylation of phenols with aryl bromides, leading to the efficient synthesis of both strained 2-hydroxybiaryl-bridged macrocycles and strain-free bimolecular counterparts. The success of this Pd-catalyzed intramolecular cyclization in generating strained macrocycles originates from the dissociation of the P( t Bu) 3 ligand from the Pd center, which facilitates dual chelation of functional groups of substrates to the Pd center of palladacycle intermediate for alleviating its strain. Additionally, Pd catalysts supported by PPh 3 promote intermolecular cyclization of the same substrates, enabling formation of larger macrocycles bridged by two 2-hydroxybiaryl motifs. These two distinct cyclization modes illustrate how phosphine ligands control the switch of chemoselectivity in Pd-catalyzed cyclizations.}, archive = {J_ANGEW}, author = {Xin Lou and Xiaofeng Zhang and Shijun Huang and Xi Deng and Xiaoming Jie and Weiping Su}, doi = {10.1002/anie.202505591}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505591}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructions of biaryl-bridged macrocycles through phosphine-ligand-controlled switch of selectivity between intra- and intermolecular cyclizations}, volume = {64}, year = {2025}, }
• (2025). Efficient ammonia electrosynthesis from pure nitrate reduction via tuning bimetallic sites in redox-active covalent organic frameworks. ANGEW, 64(26), e202505580. (www)

  @article{ , abstract = {Electrocatalytic nitrate reduction reaction (NITRR) represents a promising approach for ammonia synthesis, but existing application has been constrained by the complex proton-coupled electron transfer and the sluggish kinetics induced by various intermediates. Herein, we synthesized a series of metalized covalent organic frameworks: NiTP-MTAPP MCOFs (M = 2H, Co, Cu, and Fe), based on dual redox-active centers: thiophene-substituted Ni-bis(dithiolene) ligand-Ni[C 2 S 2 (C 4 H 2 SCHO) 2 ] 2 and metallic porphyrin. Through regulating the adsorption and desorption of species at the catalytic sites, we have identified the optimal NITRR electrocatalyst: NiTP-CoTAPP MCOF, which achieved the highest faradaic efficiency (FE) of approximately 85.6% at −0.8 V (vs. RHE) in pure nitrate solution, with an impressive yield rate of 160.2 mmol h −1 g −1 cat. The generation of active hydrogen at [NiS 4 ] sites achieved dynamic equilibrium with the timely hydrogenation reaction at CoN 4 sites, effectively suppressing the hydrogen evolution reaction. Moreover, the incorporation of thiophene (TP) groups and metal ions facilitates charge transfer. Density functional theory (DFT) calculations demonstrated the reduction in energy barriers at different catalytic sites. The CoN 4 −NiS 4 system exhibited the optimal adsorption-to-desorption capability and the lowest energy barrier (0.58 eV) for the rate-determining step (*NO → *HNO), which is supported by the moderate d-band center and Bader charge value.}, archive = {J_ANGEW}, author = {Zedong Zhang and Miao Wang and Hao-Ran Xing and Xiaocheng Zhou and Lei Gao and Shizheng Chen and Yinjuan Chen and Hui Xu and Wei Li and Shuai Yuan and Cheng-Hui Li and Zhong Jin and Jing-Lin Zuo}, doi = {10.1002/anie.202505580}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505580}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient ammonia electrosynthesis from pure nitrate reduction via tuning bimetallic sites in redox-active covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). A programmable nanoparticle conversion pathway to monodisperse polyelemental high entropy alloy, intermetallic, and multiphase nanoparticles. ANGEW, 64(26), e202505523. (www)

  @article{ , abstract = {Polyelemental nanoparticles (PE NPs), those consisting of four or more elements, exhibit unique properties from synergistic compositional effects. Examples include high entropy alloys, high entropy intermetallics, and multiphase types, including Janus and core-shell architectures. Although colloidal syntheses offer excellent structural control for mono- and bi-elemental compositions, achieving the same control for PE NPs remains challenging. Here, this challenge is addressed with a NP conversion strategy wherein different types of PE NPs – including high entropy alloy, high entropy intermetallic, and multiphase Janus nanoparticles – are achieved through thermal transformation of readily synthesized colloidal core-shell NPs. Through systematic variations in stoichiometry and metal identity to the core-shell precursor NPs, along with atomistic simulations that probe phase stabilities, we deduce that the final mixing states of the various NPs are governed by the balance between the enthalpy and entropy of mixing. Moreover, our annealing method allows us to trap NPs at intermediate states of mixing, creating distinct surface ensembles that were evaluated as catalysts for the hydrogen evolution reaction. This study is the first, to our knowledge, to report colloidally derived precursor NPs enabling the synthesis of all types of PE NPs in a single process. This NP conversion strategy offers a general route to diverse PE NPs.}, archive = {J_ANGEW}, author = {Nabojit Kar and Alberto Leonardi and Maximilian McCoy and Rukshanthan Selvaraj and Sara E. Skrabalak}, doi = {10.1002/anie.202505523}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505523}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A programmable nanoparticle conversion pathway to monodisperse polyelemental high entropy alloy, intermetallic, and multiphase nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Bismuth meets olefins: Ethylene activation and reversible alkene insertion into Bi─N bonds. ANGEW, 64(26), e202505434. (www)

  @article{ , abstract = {Owing to its fundamental properties as the parent olefin, its outstanding industrial relevance, and the challenges associated with its activation, ethylene remains a benchmark substrate, especially in main group chemistry. Here we report the unprecedented activation of ethylene and related simple α-olefins by well-defined cationic bismuth complexes. The polarization of a substrate by a softly Lewis-acidic central atom and a nucleophilic functional group positioned in a constrained geometry is for the first time exploited in the activation of ethylene and related olefins by compounds of a heavy p-block element. Mechanistic investigations point toward a coordination-insertion-reaction mechanism. The bonding properties of the cationic bismuth species facilitate unprecedented reversible reactivity patterns and unusual characteristics in chemoselectivity.}, archive = {J_ANGEW}, author = {Sangeetha Satheesh and Kai Oberdorf and Luis Roeck and Ahmed Fetoh and F. Matthias Bickelhaupt and Jordi Poater and Crispin Lichtenberg}, doi = {10.1002/anie.202505434}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505434}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bismuth meets olefins: Ethylene activation and reversible alkene insertion into Bi─N bonds}, volume = {64}, year = {2025}, }
• (2025). Harnessing the hofmeister effect for dynamic self-assembly of supramolecular hydrogels. ANGEW, 64(26), e202505417. (www)

  @article{ , abstract = {Dynamic regulation of intermolecular interactions is essential for the creation of dynamic supramolecular materials with lifelike self-regulating functions. Yet specific ion effect, which is known to possess potent effect on intermolecular interactions, has remained unexplored for such a purpose. Here, we demonstrate our access to dynamic self-assembly of supramolecular hydrogels by orchestrating the Hofmeister effect through a simple enzymatic reaction. The involved gelators containing carboxylate moieties self-assemble into hydrogel (Gel1) at acidic pH and dissolve at basic pH. We surprisingly find that the dissolved gelators at basic pH can be driven to self-assemble into hydrogel (Gel2) by kosmotropic ions through the disruption of gelator–water interactions. By coupling to the enzymatic hydrolysis of urea, Gel1 gradually disintegrates over time because of the production of basic NH 3 . However, interestingly, with the accumulation of kosmotropic ions, NH 4 + and CO 3 2− , the dissolved gelators are driven to self-assemble into Gel2, realizing a self-regulating gel–sol–gel transition process. The transition rate and stiffness of Gel2 are tunable by adjusting the concentrations of urea or urease. This work may shed light on the creation of lifelike self-regulating supramolecular materials using Hofmeister effect for many enticing applications such as ion-programmed biosensing and drug delivery.}, archive = {J_ANGEW}, author = {Hongwang Tang and Yuliang Gao and Jiahao Zhang and Zhongqi Li and Qi Gao and Peiwen Cai and Xinyu Chen and Xuhong Guo and Jan H. van Esch and Yiming Wang and Fu-Zhen Xuan}, doi = {10.1002/anie.202505417}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505417}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing the hofmeister effect for dynamic self-assembly of supramolecular hydrogels}, volume = {64}, year = {2025}, }
• (2025). Accelerated design of fenton-like copper single-atom catalysts by adaptive learning with genetic programming. ANGEW, 64(26), e202505301. (www)

  @article{ , abstract = {Traditional trial-and-error methods for optimizing catalyst synthesis are time-consuming and costly, exploring only a small fraction of the vast combinatorial space. Machine learning (ML) offers a promising alternative but still has the limitation of relying on well-selected initial datasets, which the recent development of active learning (AL) could be addressed. Here, we novelly integrate an AL-derived algorithm, the adaptive learning genetic algorithm (ALGA), into experimental workflows to optimize the synthesis of Fenton-like single-atom catalysts (SACs). Our results show that the closed-loop ALGA framework effectively learns from limited and sparse datasets, greatly reducing the research cycle compared to traditional ML and AL frameworks. By iteratively retaining better-performing genetic information and proactively expanding the search space through mutation and crossover, ALGA identifies the highest-performing Fenton-like Cu SACs with less than 90 experiments. The maximum phenol degradation rate k -value (0.147 min −1 ) achieved within the ALGA framework is approximately three times higher than that of the initial dataset and surpasses the reported best Fenton-like Cu SACs. Our successful implementation of ALGA signifies an advancement in SACs synthesis assisted by the AL-derived algorithm, offering a guiding methodology for the exploration of other functional materials.}, archive = {J_ANGEW}, author = {Haoyang Fu and Ke Li and Qingze Chen and Bijun Tang and Zhongyi Deng and Ziyang Toh and Runliang Zhu and Shuzhou Li}, doi = {10.1002/anie.202505301}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505301}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerated design of fenton-like copper single-atom catalysts by adaptive learning with genetic programming}, volume = {64}, year = {2025}, }
• (2025). Circular RNA-based molecular computation enhances plasma biomarker detection in biliary tract cancer. ANGEW, 64(26), e202505289. (www)

  @article{ , abstract = {Molecular diagnosis of biliary tract cancer (BTC) remains a significant clinical challenge due to the lack of sensitive and specific diagnostic tools. Although large panels based on multi-biomarkers have demonstrated potential in enhancing diagnostic accuracy, their clinical application is hindered by complexity and high costs. To overcome these limitations, we have developed a DNA-based molecular computation system that integrates the detection of plasma circular RNAs (circRNAs) with molecular computation, enabling intelligent and rapid diagnosis of BTC. By identifying and validating a specific and small set of circRNA biomarkers that are differentially expressed in BTC patients, we designed a DNA computation framework that directly translates biomarker levels into diagnostic outcomes without the need of external analysis and interpretation. In a validation cohort of 70 individuals, our approach achieved a diagnostic accuracy of 83%, demonstrating its potential as a cost-effective and efficient tool for rapid diagnosis of BTC. This work highlights the potential of molecular computation in enhancing integrated and rapid cancer diagnostics, paving the way for clinical implementation.}, archive = {J_ANGEW}, author = {Yunben Yang and Wenyi Lv and Yongfu Shao and Chunjing Xu and Yawei Feng and Yihui Huang and Yinye Yao and Jieer Ying and Ruizi Peng and Da Han}, doi = {10.1002/anie.202505289}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505289}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Circular RNA-based molecular computation enhances plasma biomarker detection in biliary tract cancer}, volume = {64}, year = {2025}, }
• (2025). Synergistic regulation of multi-interface chemistry by functional carbon dots for high-performance composite solid electrolytes. ANGEW, 64(26), e202505230. (www)

  @article{ , abstract = {Low ionic conductivity, poor mechanical strength, and unstable interface structure are still the main factors hindering the practical application of polymer solid-state lithium metal batteries (SSLMBs). In this work, we have developed a unique composite filler (LLZTOCDs) for solid polymer electrolytes to address these challenges through synergistic regulation of multi-interface chemistry. The LLZTOCDs is prepared via thermal treatment of N,S,F-codoped carbon dots (NSFCDs) and Li 6.5 La 3 Zr 1.5 Ta 0.5 O 12 (LLZTO) inorganic electrolyte. Here, the detrimental Li 2 CO 3 on the LLZTO surface is converted into a fast ion-conducting and an electron-insulating interlayer of LiF and Li 3 N, and the carbon dots self-assemble into a functional organophilic coating on the outermost layer, which acts as a bridge between the LLZTO and the polymer. This unique structure enhances the compatibility and ion-exchange kinetics between the LLZTOCDs and the polymer, significantly improving the mechanical strength and Li + transport. Additionally, the oxygen vacancies formed in situ at the LLZTOCDs interface provide an anion confinement effect, increasing lithium salt dissociation, and enhancing the Li + transference number to 0.85. Therefore, the solid battery constructed with LLZTOCDs exhibits excellent electrochemical stability, long-cycle life, and high ionic conductivity (1.96 × 10 − 4 S cm −1 at 25 °C), providing a feasible strategy for practical applications.}, archive = {J_ANGEW}, author = {Huaxin Liu and Fangjun Zhu and Yinghao Zhang and Yuming Liu and Yi Zhang and Wentao Deng and Guoqiang Zou and Hongshuai Hou and Xiaobo Ji}, doi = {10.1002/anie.202505230}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505230}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic regulation of multi-interface chemistry by functional carbon dots for high-performance composite solid electrolytes}, volume = {64}, year = {2025}, }
• (2025). Fullerene network-buffered platinum nanoparticles toward efficient and stable electrochemical ammonia oxidation reaction for hydrogen production. ANGEW, 64(26), e202505180. (www)

  @article{ , abstract = {Green ammonia is a promising hydrogen carrier due to its well-established production, storage, and transportation infrastructure. Moreover, hydrogen production via electrochemical ammonia oxidation reaction (AOR) requires a significantly lower theoretical potential than water electrolysis. However, the sluggish kinetics and poor stability of AOR hinder the industrial application of ammonia electrolysis. Herein, we report the construction of two-dimensional covalently bonded fullerene polymeric network (PNW-C 60 ) supported platinum nanoparticles (Pt NPs) as a highly active and stable AOR electrocatalyst. The unique electron buffering effect of PNW-C 60 enhances the desorption of nitrogen-containing species and prevents their poisoning on the Pt NPs surface. Consequently, the as-obtained PNW-C 60 -buffered Pt NPs exhibits a high mass activity of 118 A g Pt −1 as well as good stability, outperforming commercial Pt/C and graphene-supported Pt NPs AOR catalysts.}, archive = {J_ANGEW}, author = {Xiang Chen and Zhongyuan Ke and Xing Wang and Hongqiang Jin and Yuwen Cheng and Yukun Xiao and Rui Jiang and Yumin Da and Lei Fan and Hexing Li and Dongming Liu and Shangfeng Yang and Wei Chen}, doi = {10.1002/anie.202505180}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505180}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fullerene network-buffered platinum nanoparticles toward efficient and stable electrochemical ammonia oxidation reaction for hydrogen production}, volume = {64}, year = {2025}, }
• (2025). To make a painstaking investigation: Revealing the electrochemical reactions in aqueous Zn─Mn batteries. ANGEW, 64(26), e202505102. (www)

  @article{ , abstract = {The rechargeable aqueous Zn||MnO 2 batteries have been extensively explored, but the electrochemical reaction mechanisms, especially in terms of Mn 2+ /MnO 2 dissolution/deposition and Zn 2+ /H + intercalation chemistry, are still not fully understood. Herein, a Zn||MnO 2 -based battery system is constructed and the variation of the battery composition is skillfully regulated by the separation of variables. The possibility of Zn 2+ /H + intercalation chemistry is ruled out and the dominance of the dissolution/deposition mechanism is strongly demonstrated. This study confirms that the chemistry of the controversial double-discharge platform is a dissolution reaction, determined by different proton concentrations and zinc ions hydrolysis. Discharge Plateau I is the MnO 2 dissolution dominated by the surplus H + in the electrolyte, while Discharge Plateau II is the smooth discharge plateau resulting from the hydrolysis of Zn 2+ releasing protons when the proton concentration decreases to the point of Zn(OH) 2 generation. This work provides a better understanding of the dissolution/deposition mechanism of Zn||MnO 2 and paves the way for the practical application of manganese-based aqueous batteries. It also provides a comprehensive method to study the mechanism of electrochemical reactions.}, archive = {J_ANGEW}, author = {Dongxu Guo and Jie Sun and Chen Wang and Haijia Quan and Hongdi Lu and Yingjin Wei and Chenglin Sun and Shenghan Wang}, doi = {10.1002/anie.202505102}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505102}, shortjournal = {Angew. Chem. Int. Edit.}, title = {To make a painstaking investigation: Revealing the electrochemical reactions in aqueous Zn─Mn batteries}, volume = {64}, year = {2025}, }
• (2025). Catching fullerenes: Synthesis of molecular nanogloves. ANGEW, 64(26), e202505083. (www)

  @article{ , abstract = {Herein, we report the synthesis of a new series of rigid, all meta -phenylene, conjugated deep-cavity molecules, displaying high binding affinity towards buckyballs. A facile synthetic approach with an overall combined yield of approximately 53% in the last two steps has been developed using a templating strategy that combines the general structure of resorcin[4]arene and [12]cyclo- meta -phenylene. These two moieties are covalently linked via four acetal bonds, resulting in a glove-like architecture. 1 H NMR titration experiments reveal fullerene binding affinities ( K a ) exceeding ≥10 6 M −1 . The size complementarity between fullerenes and these scaffolds maximizes CH⋯π and π⋯π interactions, and their host:guest adduct resembles a ball in a glove, hence their name as nanogloves. Fullerene recognition is tested by suspending carbon soot in a solution of nanoglove in 1,1,2,2-tetrachloroethane, where more than a dozen fullerenes are observed, ranging from C 60 to C 96 .}, archive = {J_ANGEW}, author = {Saber Mirzaei and Hormoz Khosravi and Xiangquan Hu and M. Saeed Mirzaei and Victor M. Espinoza Castro and Xu Wang and Nicholas A. Figueroa and Tieyan Chang and Ying-Pin Chen and Gabriella Prieto Ríos and Natalia Isabel Gonzalez-Pech and Yu-Sheng Chen and Raúl Hernández Sánchez}, doi = {10.1002/anie.202505083}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505083}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catching fullerenes: Synthesis of molecular nanogloves}, volume = {64}, year = {2025}, }
• (2025). Metal synergistic dual activation enables efficient transesterification by multinuclear titanium catalyst: Recycling and upcycling of polyester waste. ANGEW, 64(26), e202505024. (www)

  @article{ , abstract = {Developing highly efficient and selective catalysts for chemical recycling and upcycling of plastic waste is essential for establishing a sustainable plastics economy and reducing environmental impact. Here, we report a novel tetranuclear titanium catalyst that enables highly efficient transesterification reactions of esters and polyesters. Detailed experimental and computational studies have revealed that a bi-titanium framework facilitates a dual activation mechanism, activating both alcohol and ester simultaneously, thereby significantly enhancing the transesterification process. This catalyst demonstrated exceptionally high activity in the methanolysis of poly(ethylene terephthalate) (PET) with an activity up to 1.9 × 10 7 g PET mol Ti −1 h −1 at 0.005 mol% catalyst loading, producing polymerizable dimethyl ester and glycol monomers. Additionally, it effectively catalyzed the re-polymerization of the recovered monomers, yielding the original polyester with high molecular weight and thereby achieving an ideal circular economy for commodity polyesters. Furthermore, this catalyst can also be utilized for the efficient upgrading of PET waste via transesterification with 1,4-butanediol, polybutylene adipate, and poly(tetramethyene ether glycol), yielding engineering plastic, biodegradable polyester, and thermoplastic elastomer, respectively.}, archive = {J_ANGEW}, author = {Zuowen Shi and Hao Jiang and Can Xue and Yang Yang and Zhaomin Hou and Haobing Wang}, doi = {10.1002/anie.202505024}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202505024}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal synergistic dual activation enables efficient transesterification by multinuclear titanium catalyst: Recycling and upcycling of polyester waste}, volume = {64}, year = {2025}, }
• (2025). Assembly of high-nuclearity Copper(I) alkynyl nanoclusters with exposed polyoxomolybdate templates. ANGEW, 64(26), e202504989. (www)

  @article{ , abstract = {The directed synthesis of copper(I) nanoclusters with atomically precise active sites for photocatalytic CO 2 reduction reaction (CO 2 RR) poses notable challenges. By carefully regulating the acidity of the reaction system, a set of five atomically precise Mo–Cu heterometallic nanoclusters were effectively synthesized. The adjustment of the reaction system's acidity stimulates the polymerization of molybdate, consequently influencing the encapsulation structure of the outer copper(I) shell and thereby controlling the number of catalytically active sites located at the periphery of these nanoclusters. When subjected to xenon lamp irradiation, the synthesized Mo–Cu nanoclusters, which showcase exposed polyoxomolybdates, exhibit significantly activity in the conversion of CO 2 to CO (up to 160.8 µmol g −1 h −1 ) while maintaining an impressive selectivity of up to 99.9% without any additional sacrificial agent, cocatalyst or photosensitizer. When sacrificial agent and photosensitizer were added to the CO 2 RR system, the maximum CO production rates for Mo 16 Cu 36 -1 and Mo 22 Cu 30 were 5672.1 µmol g −1 h −1 and 7370.8 µmol g −1 h −1 , respectively, with CO selectivities of 90.3% and 90.6%. The Mo─O─Cu active sites play a dual role in enhancing both CO 2 adsorption and activation, as well as facilitating charge separation. This study not only elucidates the synthesis of high-nuclearity Mo–Cu nanoclusters with potent photocatalytic activity in CO 2 RR but also contributes to advancing our comprehension of the structure-property relationship inherent in nanocluster photocatalysts.}, archive = {J_ANGEW}, author = {Jun-Jie Fang and Zheng Liu and Zhi-Yi Wang and Yun-Peng Xie and Xing Lu}, doi = {10.1002/anie.202504989}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504989}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Assembly of high-nuclearity Copper(I) alkynyl nanoclusters with exposed polyoxomolybdate templates}, volume = {64}, year = {2025}, }
• (2025). Altering the symmetry of Fe–N–C by axial cl-mediation for high-performance Zinc–Air batteries. ANGEW, 64(26), e202504923. (www)

  @article{ , abstract = {Fe–N–C catalyst is acknowledged as a promising alternative for the state-of-the-art Pt/C in oxygen reduction reaction (ORR) toward cutting-edge electrochemical energy conversion/storage applications. Herein, a “Cl-mediation” strategy is proposed on Fe–N–C for modulating the catalyst's electronic structure toward achieving remarkable ORR activity. By coordinating axial Cl atoms to iron phthalocyanine (FePc) molecules on carbon nanotubes (CNTs) matrix, a Cl-modulated Fe–N–C (FePc-Cl-CNTs) catalyst is synthesized. The as-prepared FePc-Cl-CNTs exhibit an improved ORR activity with a half-wave potential of 0.91 V versus RHE in alkaline solution, significantly outperforming the parent FePc-CNTs (0.88 V versus RHE). The advanced nature of the as-prepared FePc-Cl-CNTs is evidenced by a configured high-performance rechargeable Zn–air battery, which operates stably for over 150 h. The experiments and density functional theory calculations unveil that axial Cl atoms induce the transformation of FePc from its original D 4h to C 4v symmetry, effectively altering the electrons distribution around the Fe-center, by which it optimizes *OH desorption and subsequently boosts the reaction kinetics. This work paves ways for resolving the dilemma of Fe–N–C catalysts’ exploration via engineering Fe–N–C configuration.}, archive = {J_ANGEW}, author = {Mengni Liu and Yuxiao Liu and Xia Zhang and Linfeng Li and Xinying Xue and Muhammad Humayun and Haowei Yang and Libo Sun and Mohamed Bououdina and Jianrong Zeng and Deli Wang and Rony Snyders and Dingsheng Wang and Xin Wang and Chundong Wang}, doi = {10.1002/anie.202504923}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Altering the symmetry of Fe–N–C by axial cl-mediation for high-performance Zinc–Air batteries}, volume = {64}, year = {2025}, }
• (2025). Meticulous design of high-polarity interface material for FACsPbI3 perovskite solar cells with efficiency of 26.47%. ANGEW, 64(26), e202504902. (www)

  @article{ , abstract = {Designing new interface materials with the multifunctions of upper film crystallization control, interfacial defects passivation, and interfacial energy level regulation is crucial for developing efficient and stable perovskite solar cells (PSCs). Herein, a high polarity interfacial material, 2-cyano- N,N,N -trimethylammonium bromide (CNCB), was synthesized to engineer the buried interface between SnO 2 and perovskite of the PSCs. Comprehensive theoretical and experimental investigations demonstrate that CNCB interacts with perovskite precursors (PbI 2 and FAI) to regulate crystallization kinetics, yielding perovskite films with preferred orientation and reduced defects. Simultaneously, CNCB chemically interacts with both SnO 2 and perovskite surfaces, effectively passivating oxygen vacancies in SnO 2 and undercoordinated Pb 2 ⁺ defects at the perovskite buried surface. Furthermore, the high dipole moment of CNCB induces beneficial interfacial polarization, optimizing energy level alignment and suppressing non-radiative recombination. The CNCB-modified FACsPbI 3 PSCs achieve a champion power conversion efficiency (PCE) of 26.47% with exceptional operational stability, retaining 87.14% of their initial efficiency after 1000 h of continuous 1-sun illumination. This work establishes a molecular design paradigm for multifunctional interfacial materials in perovskite optoelectronics, highlighting the synergistic roles of crystallization control, defect passivation, and dipole engineering in high-performance devices.}, archive = {J_ANGEW}, author = {Yongzhe Li and Linlin Dong and Yan Cai and Yong Li and Dongfang Xu and Hongjie Lei and Nan Li and Zihao Fan and Jieke Tan and Rui Sun and Borui Wang and Jinyun Gong and Zilu Lin and Kunpeng Guo and Xuexia He and Zhike Liu}, doi = {10.1002/anie.202504902}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504902}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Meticulous design of high-polarity interface material for FACsPbI3 perovskite solar cells with efficiency of 26.47%}, volume = {64}, year = {2025}, }
• (2025). Self-powered electrocatalytic aldehyde reforming fuel cell for sustainable h2 generation with ∼200% faradaic efficiency. ANGEW, 64(26), e202504894. (www)

  @article{ , abstract = {Formaldehyde (HCHO), a promising yet challenging hydrogen carrier, offers a unique opportunity for efficient hydrogen generation through electro-oxidation, simultaneously eliminating harmful HCHO and contributing to environmental sustainability. This study rises to the challenge by pioneering a hybrid acid/alkali formaldehyde hydrogen production fuel cell (h-AAFHFC), an integrated system that integrates anodic partial electro-reforming of aldehydes at low potential with the cathodic hydrogen evolution reaction (HER). The device introduces a new self-powered paradigm for hydrogen generation, driven by electrochemical neutralization energy (ENE), featuring high Faradaic efficiency for hydrogen production, co-generation of electricity, and HCOOH. The h-AAFHFC attains an open-circuit voltage (OCV) of 1.11 V and a peak power density of 94 mW cm −2 , enabling simultaneous hydrogen production at both electrodes with an extraordinary Faradaic efficiency of approximately 200%. This breakthrough marks a transformative shift, moving from traditional electricity-driven systems to self-sustaining H 2 generation. Our work demonstrates a promising pathway for sustainable hydrogen production, advancing the potential of clean hydrogen energy technologies.}, archive = {J_ANGEW}, author = {Fen Hu and Kai Chen and Zhiwen Lu and Jiyuan Gao and Senchen Lan and Junxiang Chen and Suqin Ci and Zhenhai Wen}, doi = {10.1002/anie.202504894}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504894}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-powered electrocatalytic aldehyde reforming fuel cell for sustainable h2 generation with ∼200% faradaic efficiency}, volume = {64}, year = {2025}, }
• (2025). Ruthenium catalyzed ortho-arylation reaction of benzoic acids with arylthianthrenium salts. ANGEW, 64(26), e202504888. (www)

  @article{ , abstract = {Arylthianthrenium salts have become key intermediates for late-stage functionalizations of drug-like molecules. Ruthenium-phosphine catalysts are now shown to enable their use as aryl sources in high-yielding ortho -C─H arylations of benzoic acids. The arylthianthrenium salts are converted chemo-selectively, leaving aryl halides and boronates untouched. The carboxylate groups are uniquely effective as directing groups, ensuring exclusive ortho -selectivity even in the presence of competing pyridine or amide groups. This makes the reaction orthogonal to cross-couplings and conventional C─H arylations. The carboxylate group can be removed via decarboxylation or serve as an anchor for downstream transformations. Mechanistic studies identify C─H ruthenation as the rate-limiting step and highlight the unique efficiency of P(Cy)₃ ligands.}, archive = {J_ANGEW}, author = {Kaiping Wang and Xiaowen Teng and Duo Zhang and Bingxin Xu and Pan Gao and Shuli Wang and Shuwei Zhang and Lukas J. Gooßen and Feng Chen and Guodong Zhang}, doi = {10.1002/anie.202504888}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504888}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ruthenium catalyzed ortho-arylation reaction of benzoic acids with arylthianthrenium salts}, volume = {64}, year = {2025}, }
• (2025). Supramolecular recognition of a DNA four-way junction by an M2L4 metallo-cage, inspired by a simulation-guided design approach. ANGEW, 64(26), e202504866. (www)

  @article{ , abstract = {DNA four-way junctions (4WJs) play an important biological role in DNA repair and recombination, and viral regulation, and are attractive therapeutic targets. Compounds that recognise the junction structure are rare; in this work, we describe cationic metallo-supramolecular M 2 L 4 cages as a new type of 4WJ binder with nanomolar affinities. A combination of molecular dynamics (MD) simulations and biophysical experiments show that the size and shape of a compound comprising square planar Pd or Pt and anthracene-based ligands is an excellent fit for the 4WJ cavity. Whilst the cage is also capable of binding to three-way junctions (3WJs) and Y-fork structures, we show that the 4WJ is the preferred DNA target, and that duplex B-DNA is not a competitor. Among 3WJs, T-shape bulged 3WJs are bound more preferably than perfect Y-shaped 3WJs. Whilst previous work studying M 2 L 4 metallo-supramolecular cages has focused on binding inside their structures, this work exploits the external aromatic surfaces of the supramolecule, creating a supramolecular guest that ideally matches the DNA host cavity. This approach allows available structures to be identified as potential junction binders and then screened for their fit to a nucleic acid junction target using simulations. This has potential to significantly accelerate discovery.}, archive = {J_ANGEW}, author = {Samuel J. Dettmer and Hugo D. Williams and Richard Napier and Joseph M. Beames and Steffan Walker‑Griffiths and Timothy D. Craggs and Michael J. Hannon}, doi = {10.1002/anie.202504866}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504866}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular recognition of a DNA four-way junction by an M2L4 metallo-cage, inspired by a simulation-guided design approach}, volume = {64}, year = {2025}, }
• (2025). High performance capacitive deionization cathode of nickel hexacyanoferrate doped with trace molybdenum: Breaking the capacity-stability trade-off. ANGEW, 64(26), e202504775. (www)

  @article{ , abstract = {Nickel hexacyanoferrate (NiHCF) is considered one of the most promising electrode materials for capacitive deionization (CDI) because of its excellent cycling stability and other advantages. However, the poor desalination ability and low adsorption capacity caused by a single reaction site seriously restrict its practical application. Here, a high-valence transition metal element Mo-doped strategy is proposed to utilize traces of Mo 6+ to activate the inert-sites within NiHCF. The Mo-doped NiHCF electrodes (NiMo x -HCF) with multiple pairs of redox active sites and long cycling capability were designed, breaking the trade-off between high adsorption capacity and cycling stability. The results show that the preferred NiMo 0.3 -HCF not only retains the excellent cycling stability (91% after 200 cycles), but also possesses a high adsorption capacity of 90.92 mg g −1 at 1.2 V, which is much better than those of NiHCF under the same conditions. In addition, it has good practical application in simulated brackish water and circulating cooling water. Structural characterization and theoretical calculations indicate that the Mo doping strategy enhanced electronic conductivity while maintaining structural stability. This research proposes a new method to activate inert sites using high-valence elements, thus effectively balancing the adsorption capacity and cycling stability of the electrode.}, archive = {J_ANGEW}, author = {Shiyong Wang and Yuhao Lei and Gang Wang and Lin Zhao and Xiaoyan Shen and Sheng Li and Shuwen Du and Chen Yang and Jieshan Qiu}, doi = {10.1002/anie.202504775}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504775}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High performance capacitive deionization cathode of nickel hexacyanoferrate doped with trace molybdenum: Breaking the capacity-stability trade-off}, volume = {64}, year = {2025}, }
• (2025). Integrating multifunctionalities into a 3D covalent organic framework for efficient CO2 photoreduction. ANGEW, 64(26), e202504772. (www)

  @article{ , abstract = {Fabrication of highly efficient photocatalysts for CO 2 conversion is still challenging. Herein, integrating nitrogen-rich organic cages and the photoactive porphyrin moieties together, a 3D covalent organic framework (COF), Cage-PorCOF, is successfully synthesized. After incorporating metal ions (Co 2+ and Ni 2+ ) into the cage-based COF, Cage-PorCOF(Co) and Cage-PorCOF(Ni) are subsequently constructed for the CO 2 photoreduction. Catalytic experiments show impressive performance in CO 2 photoreduction with CO generation rates of up to 48 748 and 28 446 µmol g −1 h −1 in the first initiating hour for Cage-PorCOF(Co) and Cage-PorCOF(Ni), respectively, which is attributed to the synergistic effects from CO 2 -affinity of the porous frameworks and incorporated metal atoms, the light-absorption and charge separation ability of metalloporphyrin groups as well as the fully exposed single-atomic catalytic sites confirmed by both experimental and theoretical analyses. This study demonstrates that by the integration of multiple functionalities into 3D porous solids, highly effective photocatalysts for CO 2 conversion can be achieved.}, archive = {J_ANGEW}, author = {Ke Cheng and Shuo Kong and Jungeng Wang and Qiurong Wang and Shiling Yuan and Pei-Zhou Li and Yanli Zhao}, doi = {10.1002/anie.202504772}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating multifunctionalities into a 3D covalent organic framework for efficient CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). NO-enhanced sonodynamic nanovesicles with co-stimulatory molecule self-presentation for multidimensional tumor immunotherapy. ANGEW, 64(26), e202504684. (www)

  @article{ , abstract = {Synergistically improving T cell responsiveness represents a promising therapeutic strategy for tumors; however, current treatments struggle to fully activate cancer-immunity cascade. We propose a novel gas-assisted sonosensitizer-loaded biomimetic nanoplatform, triggering ultrasonic-sensitive tumor immunogenic cell death (ICD) and cascading immune activation. Upon ultrasound stimulation, the nanocore liberates reactive oxygen species and nitric oxide, generating highly toxic peroxynitrite (ONOO − ) in situ. The ONOO − then orchestrated several intracellular events, including protein S -nitrosylation, endoplasmic reticulum stress, Ca 2+ dyshomeostasis-mediated mitochondrial dysfunction, and ICD-enhanced immune cell recruitment. Furthermore, the biomimetic artificial dendritic cell (DC) membranes, from genetically engineered tumor cells, simultaneously present peptide-major histocompatibility complex class I (pMHC-I) and CD86, enabling homologous tumor targeting but also mimicking the antigen presentation and costimulatory signaling of DCs to directly activate infiltrating T lymphocytes. In multiple murine models, this nanovaccine demonstrated remarkable therapeutic efficacy, including tumor suppression, long-lasting antitumor immunity, and tumor metastasis inhibition. The ultrasound-responsive nanoDCs offer a promising paradigm for multifaceted immune boosters to address the challenges of immune tolerance and suboptimal patient response.}, archive = {J_ANGEW}, author = {Lu Zhang and Xiaoying Kang and Tianjiao Wang and Xuya Yu and Mengyun Liang and Junyan Jiang and Ji Qi and Wen Li}, doi = {10.1002/anie.202504684}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NO-enhanced sonodynamic nanovesicles with co-stimulatory molecule self-presentation for multidimensional tumor immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Structures of polyhydroxyalkanoate synthase PhaC from aeromonas caviae, producing biodegradable plastics. ANGEW, 64(26), e202504626. (www)

  @article{ , abstract = {Polyhydroxyalkanoate (PHA) is a biodegradable polyester that can serve as a promising alternative to petrochemical plastics, which present a serious source of pollution. PHA synthase (PhaC) is a key enzyme responsible for producing a wide variety of PHAs in microorganisms. Here, we present crystal structures of full-length PhaC from Aeromonas caviae , a high-performance PhaC employed for industrial use. The structure reveals an N-terminal helical domain that mediates head-to-head dimerization and stabilizes the C-terminal α/β catalytic domain to form a tunnel that connects the catalytic center embedded inside the protein to the protein surface. We showed that this tunnel is a putative egress tunnel for the product PHA chain. Our results establish a fundamental understanding of the PhaC machinery that should lead to improvement of this enzyme in industrial applications.}, archive = {J_ANGEW}, author = {Min Fey Chek and Sun-Yong Kim and Tomoyuki Mori and Keiji Matsumoto and Shunsuke Sato and Toshio Hakoshima}, doi = {10.1002/anie.202504626}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structures of polyhydroxyalkanoate synthase PhaC from aeromonas caviae, producing biodegradable plastics}, volume = {64}, year = {2025}, }
• (2025). A sustainable and scalable approach for in situ induction of gradient nucleation sites in biomass-derived interface layers for ultra-stable aqueous zinc metal batteries. ANGEW, 64(26), e202504613. (www)

  @article{ , abstract = {Aqueous zinc metal batteries are promising candidates for large-grid energy storage due to their safety, cost-effectiveness, and durability. However, challenges like dendrite growth, corrosion, and the hydrogen evolution reaction (HER) on the zinc anode hinder their performance. Herein, we propose a sustainable and scalable approach to form a copper gluconate@carboxymethyl chitosan@kaolin (CuCK) interface layer, inducing gradient nucleation sites via in situ galvanic and galvanostatic processes. The biomass-based CuCK coating features a gradient Cu x Zn y alloy structure that homogenizes interfacial electric field distribution and enhances electrochemical stability. Furthermore, the incorporated Cu 2+ -loaded kaolin and carboxymethyl chitosan regulate Zn 2+ flux, accelerate Zn 2+ desolvation, and suppress HER. The resulting Zn@CuCK anode achieves a high cumulative capacity of 5500 mAh cm −2 in symmetrical cells, exhibits excellent durability in Zn@CuCK//NaV 3 O 8 ·1.5H 2 O full cells across a wide temperature range (−30 to 60 °C), and endows the assembly of pouch cells with high energy density.}, archive = {J_ANGEW}, author = {Xin Liu and Jia-Wei Qian and Jing-Wei Chen and Yun-Kai Xu and Wei-Yi Wang and Wei-Xu Dong and Wei Hu and Guo-Rui Cai and Jun Lu and Shu-Hong Yu and Li-Feng Chen}, doi = {10.1002/anie.202504613}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504613}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A sustainable and scalable approach for in situ induction of gradient nucleation sites in biomass-derived interface layers for ultra-stable aqueous zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Cooperative Iron–Aluminium reactivity for dinitrogen activation. ANGEW, 64(26), e202504538. (www)

  @article{ , abstract = {We report a novel bimetallic approach utilizing cooperative Fe─Al reactivity for N 2 activation on the Cp*Fe(1,2-Cy 2 PC 6 H 4 AlEt) platform, effectively capturing two N 2 molecules through intermolecular Fe─N≡N─Al coordination. Characterizations of the N 2 -bridged Fe─Al dimer ( 2 ) using Mössbauer spectroscopy coupled to density functional theory (DFT) calculations reveals its electronic structure as a resonance hybrid between Fe(II)-Al(I) and Fe(0)-Al(III). The flexible, covalent Fe─Al bonding facilitates the subsequent alkylation of the Al site with n BuLi, leading to the formation of a dinitrogen-lithiated complex ( 3 ) that enables the silylation of the terminal N atom. Our findings highlight the significance of leveraging Fe─Al effects as an electron buffer to achieve facile N 2 activation.}, archive = {J_ANGEW}, author = {Qiucui Zheng and Xuebin Jiang and Rui Sun and Jiaxin Zhang and Shengfa Ye and Chen-Ho Tung and Wenguang Wang and Li-Zhu Wu}, doi = {10.1002/anie.202504538}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504538}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative Iron–Aluminium reactivity for dinitrogen activation}, volume = {64}, year = {2025}, }
• (2025). Influence of ligand design and non-covalent interactions on the isoselective ring-opening polymerization of rac-β-butyrolactone using salan and salalen rare-earth metal catalysts. ANGEW, 64(26), e202504513. (www)

  @article{ , abstract = {We herein report the influence of the ligand framework on the isoselective ring-opening polymerization (ROP) of rac -β-butyrolactone using highly active in situ generated salan [ONNO] H2 and salalen [ONNO] H rare-earth metal complexes. The stereochemistry was found to be highly dependent on the ortho -substituents, enabling the synthesis of either isotactic poly(3-hydroxybutyrate) (PHB) (up to P m = 0.92) or syndiotactic PHB (up to P r = 0.91). To obtain further information on the mechanism of the isoselective ROP, which exhibits an enantiomorphic site control (ESC), a new hybrid Y[ONNO] H (N(SiHMe 2 ) 2 )(THF) complex was isolated and characterized via NMR, DFT, and mass-spectrometry experiments. The impact of non-covalent interactions (NCIs) was demonstrated by the addition of NCI inhibitors. Kinetic studies revealed a secondary kinetic isotope effect (SKIE) of 1.14, indicating that the pre-coordination of the monomer plays a significant role in the mechanism. These findings provide a foundation for the future design of catalysts for isoselective ROP.}, archive = {J_ANGEW}, author = {Stefanie Hörl and Ion Chiorescu and Jonas Bruckmoser and Jonas Futter and Bernhard Rieger}, doi = {10.1002/anie.202504513}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504513}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Influence of ligand design and non-covalent interactions on the isoselective ring-opening polymerization of rac-β-butyrolactone using salan and salalen rare-earth metal catalysts}, volume = {64}, year = {2025}, }
• (2025). β-quaternary α-amino acids via iridium-catalyzed branched and enantioselective hydroalkylation of 1,1-disubstituted styrenes. ANGEW, 64(26), e202504477. (www)

  @article{ , abstract = {A cationic Ir(I)-complex modified with the chiral diphosphine DM-SEGPHOS mediates the hydroalkylation of diverse α-methyl styrenes with N-aryl glycine derivatives. The processes occur with complete branched selectivity and high enantioselectivity. Styrenes possessing higher α-alkyl substituents also participate to provide the targets with moderate to excellent levels of diastereoselectivity. The products are readily advanced to β-quaternary α-amino acids that are inaccessible or cumbersome to access by other means. In broader terms, the study demonstrates how catalyst controlled C─H additions across alkenes can be used to execute the by-product-free construction of contiguous acyclic trisubstituted and quaternary centers.}, archive = {J_ANGEW}, author = {Fenglin Hong and Yihong Wang and L. Anders Hammarback and Craig M. Robertson and John F. Bower}, doi = {10.1002/anie.202504477}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504477}, shortjournal = {Angew. Chem. Int. Edit.}, title = {β-quaternary α-amino acids via iridium-catalyzed branched and enantioselective hydroalkylation of 1,1-disubstituted styrenes}, volume = {64}, year = {2025}, }
• (2025). Manganese-catalyzed enantioselective dearomative epoxidation of naphthalenes with aqueous hydrogen peroxide. ANGEW, 64(26), e202504356. (www)

  @article{ , abstract = {Arenes are abundantly occurring molecules of significant interest as versatile starting materials in organic reactions. Typically, oxidation of arenes yields planar molecules such as phenols and quinones. However, several iron dependent oxygenases can disrupt the aromaticity of arenes through oxidation and introduce C(sp 3 )─O stereogenic centers, resulting in precious enantioenriched epoxide or diol products. Emulating this enzymatic behavior with synthetic catalysts has met little success until now. Herein we describe a catalytic chemo- and enantioselective dearomative epoxidation of naphthalenes. The singular chemo- and enantioselectivity features of the reaction critically rely on a manganese catalyst that combines electron donating groups and steric demand on the ligand and activates hydrogen peroxide under mild conditions and short reaction times. Assisted with an N -protected amino acid, this catalyst epoxidizes a range of naphthalenes providing chemically versatile diepoxides in moderate to good yields and high levels of enantioselectivity. Straightforward elaboration gives diverse access to densely functionalized 3D structurally rich oxygenated molecules. The reaction constitutes a paradigmatical example of expedient access to stereochemically rich, valuable oxygenated molecules from readily available feedstocks, enabled by highly reactive yet selective biologically inspired oxidation catalysts.}, archive = {J_ANGEW}, author = {Najoua Choukairi Afailal and Siu-Chung Chan and Miquel Costas}, doi = {10.1002/anie.202504356}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504356}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manganese-catalyzed enantioselective dearomative epoxidation of naphthalenes with aqueous hydrogen peroxide}, volume = {64}, year = {2025}, }
• (2025). Tuning atomically precise gold nanoclusters for selective electroreduction of CO2. ANGEW, 64(26), e202504320. (www)

  @article{ , abstract = {The electroreduction of greenhouse gas CO 2 into high-value-added chemicals using renewable electricity is a promising way to mitigate climate change and realize carbon cycling. Atomically precise thiolate-protected gold nanoclusters have shown great potential for selective electrochemical conversion of CO 2 toward CO due to their quantum confinement effect and unique electronic structures. Additionally, the atomic precision of gold nanocluster is advantageous for investigating the CO 2 reduction mechanism, which is typically challenging to understand due to the complexity of the catalytic interface, and unknown structure of the active site in more conventional catalysts. By summarizing CO 2 reduction catalyzed by gold nanoclusters, we aim to identify key factors that contribute to the activity, selectivity, and stability of nanocluster catalysts, as well as elucidate the CO₂ reduction pathway, thereby contributing to the design of more active and selective nanocluster catalysts for CO 2 reduction.}, archive = {J_ANGEW}, author = {Jiangtao Zhao and Abolfazl Ziarati and Thomas Bürgi}, doi = {10.1002/anie.202504320}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504320}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning atomically precise gold nanoclusters for selective electroreduction of CO2}, volume = {64}, year = {2025}, }
• (2025). Titanium-mediated rearrangement of bis(alkynyl)boranes: B─C activation versus C─H activation. ANGEW, 64(26), e202504229. (www)

  @article{ , abstract = {Reactions between Rosenthal's titanocene (Cp 2 Ti) and decamethyltitanocene (Cp* 2 Ti) synthons with various bis(alkynyl)boranes were investigated. A series of titanium-fused boracyclobutenes were obtained through the reaction of the Cp* 2 Ti synthon with (Me 3 Si) 2 NB(CCR) 2 or PhB(CCPh) 2 . This represents the first realization of approaching this structural motif via the rearrangement of bis(alkynyl)boranes within the coordination sphere of a d -block metal. These findings break the previous limitation that the boron substituent must be an amino group. Furthermore, the reaction of the Cp* 2 Ti synthon with (Me 3 Si)PhNB(CCPh) 2 or (Mes 2 B)PhNB(CCPh) 2 (Mes = 2,4,6-trimethylphenyl) led to the formation of novel tethered metallocene complexes, in which the titanacyclopentadiene structure is linked to one of the cyclopentadienyl groups via a ─CH 2 ─BR─ bridge. Both experimental and theoretical studies provided insights into an unprecedented reaction mechanism. The process involves the initial formation of an η 2 -coordinated bis(alkynyl)borane intermediate, which was detected and analyzed by NMR spectroscopy and X-ray diffraction analysis. This intermediate subsequently undergoes either B─C alkynyl bond activation or C Me ─H activation of the Cp* ligand, leading to the formation of two distinct types of products.}, archive = {J_ANGEW}, author = {Chenchang Ma and Alexander Matler and Shuai Zhu and Thayalan Rajeshkumar and Laurent Maron and Qing Ye}, doi = {10.1002/anie.202504229}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504229}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Titanium-mediated rearrangement of bis(alkynyl)boranes: B─C activation versus C─H activation}, volume = {64}, year = {2025}, }
• (2025). Leaching-induced ti trapping stabilizes amorphous IrOx for proton exchange membrane water electrolysis. ANGEW, 64(26), e202504212. (www)

  @article{ , abstract = {Transition metal nitrides are promising conductive support materials in oxygen evolution reaction (OER), whereas it is unclear if their electrochemical oxidation during prolonged test would affect the OER catalysts. Herein, we demonstrate that the leaching-induced Ti trapping effect from TiN supports effectively stabilizes the electrochemically oxidized amorphous IrO x catalyst. Structural characterizations reveal that the TiN support experiences severe leaching during OER test, leaving minor amounts of Ti–O species trapping on IrO x clusters, which mitigate the overoxidation of Ir(III) species and elongate the Ir–O bonds. This leads to 70% reduction of lattice oxygen oxidation and the substantially reduced Ir leaching. Additionally, self-thickening of the catalyst layers is found during proton exchange membrane water electrolysis (PEMWE), enabling an ultralow catalyst loading of 87 µg Ir cm −2 to obtain a stable operation at 1.0 A cm −2 for 500 h. This work deepens the understanding of TiN-supported catalysts for long-term stable OER electrocatalysis.}, archive = {J_ANGEW}, author = {Hao Yang Lin and Wen Jing Li and Miao Yu Lin and Hao Guan Xu and Song Ru Fang and Yao Lv and Wenbo Li and Jianwei Guo and Huai Qin Fu and Hai Yang Yuan and Chenghua Sun and Sheng Dai and Peng Fei Liu and Hua Gui Yang}, doi = {10.1002/anie.202504212}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504212}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leaching-induced ti trapping stabilizes amorphous IrOx for proton exchange membrane water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Adaptive defluoroamination of aryl fluorides: Harnessing the catalytic potential of a unique zinc amide compound. ANGEW, 64(26), e202504156. (www)

  @article{ , abstract = {The activation and functionalization of C─F bonds, the strongest bonds between carbon and any other element, via C─N bond formation to generate complex molecules has remained a compelling challenge. Herein, we present a ligand-centered redox-controlled effective strategy employing a zinc amide catalyst ( C ) to achieve facile defluoroamination of fluoroarenes with several N-nucleophiles (>90 substrates) under mild conditions. Notably, this adaptable protocol works readily with most types of fluoroarenes and a diverse range of N─H moieties that include secondary and primary amines, indoles, azoles, and amides under the same reaction conditions and encouragingly offers excellent functional group compatibility. Intriguingly, we also demonstrated its application in one-pot synthesis of (un)symmetrical triaryl amines from primary amine itself and the selective activation of C─F bonds to access F-containing amines, relevant to drug synthesis. Finally, detailed mechanistic probes via active-intermediate-capture, EPR analysis, and various control experiments indicate that the reaction proceeds through a radical-mediated C─N coupling pathway. Importantly, use of Zn(II) center as a template to hold the two amide moieties together in C enables facile intramolecular electron transfer to generate the radical intermediates for the present protocol. Finally, the practical utility of this methodology was showcased by synthesizing various drug derivatives.}, archive = {J_ANGEW}, author = {Sangita Sahoo and Arnab Rit}, doi = {10.1002/anie.202504156}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504156}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Adaptive defluoroamination of aryl fluorides: Harnessing the catalytic potential of a unique zinc amide compound}, volume = {64}, year = {2025}, }
• (2025). Adaptive mo-fe-S clusters: Consistent redox behavior versus reversible structural transformations. ANGEW, 64(26), e202504016. (www)

  @article{ , abstract = {Iron-sulfur clusters are critical in a number of important biological processes, where their structural integrity can be maintained or reversibly transformed. However, it remains ambiguous how Fe-S clusters adapt to electrochemical demands for electron transport through redox-induced structural transformations. In this study, three Mo-Fe-S clusters comprising similar or distinct cores with [Mo 2 Fe 2 ] metal centers in different oxidation states have been synthesized. These chemically interconvertible clusters exhibit strikingly similar cyclic voltammetry (CV) curves, irrespective of the structural differences in the core. Subsequent investigations indicate that the chloride ligand in cluster 2 is spontaneously replaced by the solvent molecule in solution and therefore only the solvent-ligated species exhibits an observable redox behavior that is almost identical to that of the chloride-free clusters 3 and 4 . A comprehensive analysis of the redox behavior suggests that the intriguing redox events in the CV curves can be correlated to the electrochemical transformations between the chloride-free clusters. This work provides an insight into how Fe-S clusters maintain a stable redox behavior through structural transformations that can facilitate electron transfer in certain cases.}, archive = {J_ANGEW}, author = {Jia Wei and Juan He and Gan Xu and Xu-Dong Chen}, doi = {10.1002/anie.202504016}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504016}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Adaptive mo-fe-S clusters: Consistent redox behavior versus reversible structural transformations}, volume = {64}, year = {2025}, }
• (2025). A fluorine-free Organic/Inorganic interphase for highly reversible aqueous zinc batteries. ANGEW, 64(26), e202504003. (www)

  @article{ , abstract = {Construction of robust solid electrolyte interphases (SEIs) has proved effective in mitigating dendrite growth and side reactions of zinc (Zn) anodes in aqueous electrolytes. Fluorinated SEIs, in particular, have garnered significant attention due to their exceptional electrochemical stability and high Zn 2+ conductivity. However, the formation of such SEIs typically relies on the use of fluorine (F)-containing precursors, which inadvertently raise environmental and biological concerns because they show high resistance to degradation in natural environments. Herein, we develop an F-free organic/inorganic hybrid SEI for aqueous Zn batteries using a low-cost N-acetyl-D-glucosamine (NAG) electrolyte additive. The NAG additive not only modulates the solvation structure of Zn 2+ but also preferentially adsorbs on the Zn anode to promote the in situ formation of a robust organic (Zn chelates)/inorganic (ZnS and ZnCO 3 ) hybrid SEI layer, thereby enhancing Zn 2+ de-solvation kinetics and Zn plating/stripping reversibility. Consequently, the Zn anode exhibits a long-term cycling over 6500 h at 0.5 mA cm ‒2 , a high average Coulombic efficiency of 99.6% at 1 mA cm ‒2 , and greatly extended cycling stability in full cells (up to 2000 cycles). Our electrolyte design paves a promising avenue toward practical Zn batteries that combine performance, cost-effectiveness, and eco-friendliness.}, archive = {J_ANGEW}, author = {Xingfu Yang and Xiaoning Tang and Jie Lei and Xu Zeng and Jie Wen and Anni Liu and Shu Xia and Qiuyang Luo and Junnan Liu and An Xue and Daliang Han and Guangmin Zhou}, doi = {10.1002/anie.202504003}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202504003}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A fluorine-free Organic/Inorganic interphase for highly reversible aqueous zinc batteries}, volume = {64}, year = {2025}, }
• (2025). Mn–N–C with high-density atomically dispersed mn active sites for the oxygen reduction reaction. ANGEW, 64(26), e202503934. (www)

  @article{ , abstract = {The utilization of transition metal–based catalysts as alternatives presents an attractive solution for enhancing the sluggish oxygen reduction reaction (ORR) and reducing costly platinum-based electrocatalysts in hydrogen fuel cells. Manganese-based nitrogen–carbon (Mn–N–C) is anticipated to exhibit durability due to its weaker Fenton reaction propensity. However, a key obstacle lies in boosting intrinsic electrocatalytic activity and increasing the density of Mn active sites, crucial for practical integration into fuel cell operations. Herein, a three-step method is developed to synthesize atomically dispersed Mn–N–C materials with a rich mesoporous structure as highly effective ORR catalysts. The high Mn loading (3.42 wt%) promotes the generation of Duo-MnN 4 active sites, demonstrating outstanding performance and durability for fuel cells. Specifically, the exceptional performance of proton exchange membrane fuel cells (PEMFC) reaches 649 mW cm −2 and anion exchange membrane fuel cells (AEMFC) achieves 770 mW cm −2 . Notably, the durability of the Mn–N–C catalyst in PEMFC is reported for the first time, showing only 18.4% decay after 30 000 square-wave cycles. This work provides a unique perspective and a systematic design strategy for building feasible nonprecious metal catalysts with a high active site density, addressing the challenges of inefficiency and performance limitations across various electrocatalytic applications.}, archive = {J_ANGEW}, author = {Gongjin Chen and Xiaoyi Qiu and Shiyuan Liu and Yingdan Cui and Yan Sun and Yan Zhang and Yushen Liu and Guimei Liu and Yoonseob Kim and Wei Xing and Haijiang Wang and Minhua Shao}, doi = {10.1002/anie.202503934}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503934}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mn–N–C with high-density atomically dispersed mn active sites for the oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Unnatural triggers converted from tetrazine-attached sialic acid for activation of optoacoustic imaging-guided cancer theranostics. ANGEW, 64(26), e202503850. (www)

  @article{ , abstract = {Constructing chemical groups on cell membranes through metabolic glycoengineering of unnatural sugars is an effective means to solve the issue of insufficient or even lack of targets in cancer theranostics. Herein, we address the limitations by developing a tetrazine precursor (SiaTz) based on a non O -acetylated sialic acid scaffold and then utilizing it to create unnatural tetrazine triggers on the surface of cancer cells. SiaTz exhibits a good balance between the stability and reaction kinetics under physiological conditions and can be efficiently converted into corresponding tetrazine trigger through bypassing several size-limiting steps in metabolic glycoengineering process. We also prepare a proof-of-concept theranostic combination of a trans -cyclooctene derivative (CyTCO) and a thermal-sensitive drug 2,2′-azobis[2-(2-imidazolin-2-yl) propane]-dihydrochloride (AIPH) to verify the activation function of tetrazine triggers in theranostics of orthotopic and metastatic tumors. In the presence of tetrazine triggers, CyTCO can be activated via bio-orthogonal reaction to induce optoacoustic signal enhancement, enabling high-contrast diagnostic imaging and precise tumor localization to guide subsequent treatments. Tetrazine trigger-activated CyTCO displays high photo-to-heat conversion efficiency, which can cause an obvious increase in temperature under laser irradiation and then initiate AIPH decomposition to produce toxic radicals for combined therapy.}, archive = {J_ANGEW}, author = {Yinglong Wu and Lihe Sun and Xiaodong Zhang and Wenbin Zhong and Xiaokai Chen and Shihuai Wang and Yun Chen and Dongdong Wang and Ting He and Hongzhong Chen and Jingjing Guo and Fang Zeng and Menghuan Li and Zhong Luo and Shuizhu Wu and Yanli Zhao}, doi = {10.1002/anie.202503850}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503850}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unnatural triggers converted from tetrazine-attached sialic acid for activation of optoacoustic imaging-guided cancer theranostics}, volume = {64}, year = {2025}, }
• (2025). Tumor microenvironment-responsive polymer delivery platforms for cancer therapy. ANGEW, 64(26), e202503776. (www)

  @article{ , abstract = {Most chemotherapeutic and bioimaging agents struggle with inadequate bioavailability, primarily due to their limited biocompatibility and lack of specificity in targeting, leading to low or decreased anticancer efficacy and inaccurate imaging. To surmount these obstacles, the development of stimuli-responsive polymer delivery platforms, predominantly leveraging the tumor microenvironment (TME), has emerged as a promising strategy. Therapeutic and diagnostic agents can be released controllably at the tumor site by virtue of the bond cleavage or hydrophobic to hydrophilic transformation of TME-sensitive linkages in TME-responsive systems, thus augmenting cancer treatment and imaging precision, while simultaneously attenuating the damage to healthy tissues and false imaging signals caused by non-specific drug leakage. In this comprehensive review, we scrutinize recent studies of TME-responsive polymer delivery platforms, encompassing pH-, ROS-, GSH-, enzyme-, and hypoxia-responsive vectors, significantly from the perspective of their molecular design and responsive mechanism, and further summarizing their bio-application in drug delivery and diagnostic imaging. Moreover, this review encapsulates the critical challenges and offers an insightful perspective on the future prospects of TME-responsive polymer delivery platforms in terms of molecular and vector design.}, archive = {J_ANGEW}, author = {Yiqi Shi and Qianqian Yu and Lijie Tan and Qi Wang and Wei-Hong Zhu}, doi = {10.1002/anie.202503776}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tumor microenvironment-responsive polymer delivery platforms for cancer therapy}, volume = {64}, year = {2025}, }
• (2025). In situ cation exchange enables air-processed inverted perovskite solar cells with over 25% efficiency and enhanced stability. ANGEW, 64(26), e202503702. (www)

  @article{ , abstract = {The scalable fabrication of inverted perovskite solar cells (IPSCs) in humid air with an antisolvent-free process is essential for future industrial applications. However, high humidity poses significant challenges for achieving high-quality perovskite films, making it difficult to attain efficient IPSCs under ambient conditions. Here, we present an in situ cation exchange strategy to create a compact and uniform PbI₂ shell on the perovskite surface by using ZnI₂ in acetonitrile (ACN), where Zn 2+ replaces Pb 2+ . This transformation is attributed to the surface defects of the perovskite, which undergo a cation exchange reaction in humid air, forming a compact PbI₂ shell. The n-type PbI₂ shell effectively encapsulates the perovskite films, minimizing air exposure while optimizing energy level alignment, thereby enhancing electron transport and extraction. As a result, we demonstrate IPSCs with efficiencies of 25.2% under ambient conditions (25°–30 °C, 60% ± 10% relative humidity [RH]), on par with state-of-the-art devices fabricated in inert atmospheres. The devices demonstrated remarkable stability, enduring aging tests under the International Summit on Organic Photovoltaic Stability (ISOS) protocols ISOS-D-1I and ISOS-D-2I for over 4770 and 2000 h, respectively.}, archive = {J_ANGEW}, author = {Ligang Xu and Wei Qian and Yuhan Zhou and Zijie Wei and Hailong Wang and Wenzhen Lv and Jing Li and Wenchao Huang and Lin Yao and Runfeng Chen and Wei Huang}, doi = {10.1002/anie.202503702}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ cation exchange enables air-processed inverted perovskite solar cells with over 25% efficiency and enhanced stability}, volume = {64}, year = {2025}, }
• (2025). A single-molecule liposome assay for membrane permeabilization. ANGEW, 64(26), e202503678. (www)

  @article{ , abstract = {Cell membrane disruption is associated with numerous diseases and underlies the activity of various antimicrobial agents. The rapid screening of compounds capable of disrupting or permeabilizing biological membranes is essential to the search for new therapeutic drugs. Here, we present a single-molecule confocal microscopy assay integrated with fast-flow microfluidics to study membrane permeabilization in large unilamellar vesicles (LUVs) containing as few as seven dye molecules. This assay eliminates the need for liposome immobilization and achieves detection rates in the range of 1000 vesicles per minute, offering unparalleled sensitivity and detection limits as low as 135 pM, corresponding to just eight permeabilizing molecules per vesicle for active compounds such as ionomycin. It provides a robust platform for investigating membrane-disrupting agents, including those with antimicrobial properties or implicated in neurodegenerative diseases.}, archive = {J_ANGEW}, author = {Krzysztof M. Bąk and Daniel C. Edwards and Dylan George and Bhanu Singh and Ryan Ferguson and Tianxiao Zhao and Kristin Piché and Ariel Louwrier and Scott L. Cockroft and Mathew H. Horrocks}, doi = {10.1002/anie.202503678}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503678}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A single-molecule liposome assay for membrane permeabilization}, volume = {64}, year = {2025}, }
• (2025). Bio-sourced 4-aryl-1,2-dithiolanes for recyclable poly(disulfide)s with high performance. ANGEW, 64(26), e202503677. (www)

  @article{ , abstract = {The development of recyclable polymers presents a solution to the urgent issues of circular plastics economy. To this end, there is an increasing interest in expanding the utility of poly(disulfide)s, which contains dynamic covalent S─S bonds to enable intrinsic degradability. Lipoic acid and its derivatives represent the most widely used class of monomers for the preparation of poly(disulfide)s. However, their physical properties are usually on the soft side of thermoplastics and can face challenges in wider applications. In this contribution, we report a scalable synthesis of a new class of aryl-substituted 1,2-dithiolane monomers from bio-sourced phenol ethers and their ring-opening polymerization to aryl-substituted poly(disulfide)s. The aryl-substituted poly(disulfide)s display high recyclability without the cost of stability. The introduction of aryl side chains systematically improves the thermal properties of poly(disulfide)s. The optical properties of aryl-substituted poly(disulfide)s are competitive and so are the mechanical properties of the crosslinked network, showing potential for applications in sustainable materials.}, archive = {J_ANGEW}, author = {Tianyu Zhu and Ruishi Lei and Bowen Wang and Tianyi Du and Wei Xia and Yun Liu}, doi = {10.1002/anie.202503677}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503677}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bio-sourced 4-aryl-1,2-dithiolanes for recyclable poly(disulfide)s with high performance}, volume = {64}, year = {2025}, }
• (2025). Pore engineering in isoreticular titanium-isophthalate coordination polymers. ANGEW, 64(26), e202503618. (www)

  @article{ , abstract = {Pore engineering through chemical environment modification is vital for developing industrial porous materials. Understanding the effects of substitutions in isoreticular porous coordination polymers—such as steric hindrance, vibrational capabilities, electronic influences, and hydropathy—is key to elucidating structure–property relationships. However, accurately assessing the impact of functional groups on properties remains challenging due to limitations in current methodologies. In this study, we designed a series of titanium-isophthalate coordination-polymers with various functional groups to regulate pore characteristics and structural dimensionality. The unique spatial arrangement and electronic distribution of isophthalate and its functional groups provide an ideal platform to address these challenges. We conducted extensive investigations combining experimental methods with computational simulations to explore how pore engineering affects adsorptive separation and photoresponsive behavior in these compounds. Our findings not only tackle the synthesis challenge of isostructural titanium-coordination polymers but also offer new insights into understanding structure–property relationships achieved through modulation of their chemical environments.}, archive = {J_ANGEW}, author = {Qingqing Yan and Chenyang Nie and Valentin Diez Cabanes and Fu-An Guo and Yafei Du and Hailun Xia and Hao Wang and Guillaume Maurin and Peng Guo and Sujing Wang}, doi = {10.1002/anie.202503618}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pore engineering in isoreticular titanium-isophthalate coordination polymers}, volume = {64}, year = {2025}, }
• (2025). Nanoconfined ultrathin polymer membrane for ultrafast separation of biobutanol from water. ANGEW, 64(26), e202503501. (www)

  @article{ , abstract = {Efficient recovery of biobutanol, a next-generation biofuel, from fermentation liquor remains challenging due to its low concentration and volatility. This study introduces ultrathin rubbery polymer membranes developed through an interfacial dissolution–crosslinking method, with cross-linked polysiloxane confined within the permanent nanovoids of ceramic alumina substrates. The resulting membranes, which are less than 10 nm thick, achieve unparalleled performance: concentrating 1.0 wt% aqueous n -butanol 14.2-fold with a record-high liquid flux of 110 kg m −2 h −1 —one to two orders of magnitude greater than those of previously reported membranes. These advancements suggest significant reductions in the membrane area and operational costs for large-scale biobutanol separation, establishing a sustainable and economical solution for biofuel production.}, archive = {J_ANGEW}, author = {Jiayi Liu and Yujie Ban and Guangqi Zhu and Ziyi Hu and Weishen Yang}, doi = {10.1002/anie.202503501}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503501}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanoconfined ultrathin polymer membrane for ultrafast separation of biobutanol from water}, volume = {64}, year = {2025}, }
• (2025). Probing the catalytic degradation of unsaturated polyolefin materials via fe-based lewis acids-initiated Carbonyl–Olefin metathesis. ANGEW, 64(26), e202503408. (www)

  @article{ , abstract = {Degradation and recyclability of polymeric materials, including extensively used polyolefins, are becoming increasingly necessary. Chemically stable saturated polyolefin backbones make their degradation frustratingly challenging. The current effective strategy is to create cleavable defects, e.g., C═C double bonds along the backbone, and subsequently depolymerize them via cross-metathesis reaction with olefins. High-value chemicals or reusable polymeric segments are obtained. This two-step protocol provides operable means for alleviating plastics problems. There are several approaches to introduce unsaturation into a polymer backbone, like dehydrogenation or copolymerization of olefins and conjugated dienes. However, for the second step, to conduct a cross-metathesis reaction, only noble metal catalysts can be used most of the time. Regardless of their limited availability, the fact that these organometallics are unfavorably sensitive to impurities would raise barriers in industrial practices. Herein we employed earth-abundant and inexpensive iron-based Lewis acids to initiate carbonyl–olefin metathesis reactions between ketone/aldehyde reagents and unsaturated polyolefins. After explorations in poly(diene)s and industrial thermoplastic elastomers, we extended this protocol to degrade low-density polyethylene (LDPE). Low-molecular weight PE wax-like products were obtained as useful chemicals. This catalytic degradation system is expected to enable the development of more efficient metathesis strategies to promote degradation of polyolefins and pave sustainable ways for reuse of polymeric materials.}, archive = {J_ANGEW}, author = {Liangyu Chen and Zhihao Wang and En Fang and Zhiqiang Fan and Shaofei Song}, doi = {10.1002/anie.202503408}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503408}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing the catalytic degradation of unsaturated polyolefin materials via fe-based lewis acids-initiated Carbonyl–Olefin metathesis}, volume = {64}, year = {2025}, }
• (2025). Iron(III)-catalyzed C─H hydroxylation of low-density polyethylene coupled with short chain branching growth. ANGEW, 64(26), e202503405. (www)

  @article{ , abstract = {Low-density polyethylene (LDPE) is widely used in packaging applications, but after being discarded its environmental impact is a pressing concern due to a lack of effective chemical recycling strategies, especially owing to its chemical inertness and nonpolar nature. To address these challenges, we present a mild iron(III)-catalyzed oxidative upcycling of LDPE in which C─H hydroxylation of LDPE occurs coupled with the growth of methyl short chain branching (Me-SCB) and ethyl shortchain branching (Et-SCB). As a result, the resulting products achieve significant improvements in surface wettability, crystallinity, and mechanical properties despite a concomitant reduction in molecular weight. CH…F interactions and σ–π interactions are found between LDPE and the catalyst. Density functional theory (DFT) calculations elucidate the catalytic mechanism that fluorine on the ligand facilitates hydrogen peroxide activation and subsequent deprotonation, leading to the formation of high-valent ironoxo species. The growth of short-chain branching (SCB) involves the β-scission of CC bonds and a radical-mediated chain-walking mechanism. This work represents a transformative advancement in deep understanding of polyolefin upcycling and opens a new approach of polyolefin functionalization and architecture modulation.}, archive = {J_ANGEW}, author = {Pengbo Ye and Xiangyue Wei and Chengfeng Shen and Xuehui Liu and Shimei Xu and Yu-Zhong Wang}, doi = {10.1002/anie.202503405}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503405}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron(III)-catalyzed C─H hydroxylation of low-density polyethylene coupled with short chain branching growth}, volume = {64}, year = {2025}, }
• (2025). Deciphering the crystallographic effect in radially architectured polycrystalline layered cathode materials for lithium-ion batteries. ANGEW, 64(26), e202503108. (www)

  @article{ , abstract = {Layered oxide cathode materials with primary–secondary architecture face challenges of inhomogeneous Li + diffusion and chemomechanical degradation due to misorientations between equiaxed primary particles. Although a radial architecture, featuring elongated grains, is widely believed to enhance diffusion, it does not address the root cause of chemomechanical failure—crystallographic misorientation. The impact of crystallography on the electrochemical performance of radially architectured secondary particles, compared to conventional designs, remains poorly understood. Here, by combining transmission Kikuchi diffraction with multimodal characterization, we decipher the crucial role of crystallography in the performance and stability of polycrystalline high-Ni layered oxide cathode materials. Contrary to the conventional belief that a preferential texture induced by the radial architecture is the key to performance enhancement, we uncover that the radial architecture primarily alters the misorientation distribution by introducing substantially increased low-angle grain boundaries and twin boundaries that significantly mitigate chemomechanical cracking and phase degradation. This crystallographic refinement facilitates enhanced Li + diffusion between primary particles, ultimately boosting the rate capability and long-term stability of the cathodes. By quantitatively uncovering the crystallographic influence on performance, this work provides a new avenue for optimizing Li + diffusion kinetics and chemomechanical resilience in polycrystalline cathode materials through crystallographic engineering.}, archive = {J_ANGEW}, author = {Pei Tang and Siqi Guan and Chen Wu and Huize Wu and Ni Lu and Jun Tan and Chunyang Wang and Hui-Ming Cheng and Feng Li}, doi = {10.1002/anie.202503108}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503108}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering the crystallographic effect in radially architectured polycrystalline layered cathode materials for lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic nitrogen reduction for ammonia synthesis accelerated by overcoming photo-dember effect. ANGEW, 64(26), e202503097. (www)

  @article{ , abstract = {During photocatalytic nitrogen fixation for ammonia synthesis, the photo-Dember effect causes direct transmission of photogenerated electrons from the illuminated surface to the bottom of photocatalyst, thus significantly reducing the number of charge carriers migrating on the surface and nitrogen fixation efficiency. Herein, a bismuth oxychloride material with largely exposed (101) crystal plane and rich oxygen vacancies (BOC (101) -OVs) is synthesized, exhibiting a high NH 3 yield of 591.94 µmol g −1 h −1 ) after photocatalytic N 2 reduction under simulated solar light irradiation. The designed (101)/(001) interface in BOC (101) -OVs generates a self-built electric field ( E self ) on the material surface due to different atomic arrangements. Therefore, the newly developed material achieved >95% of photogenerated electrons changing the transfer path, i.e., from bulk phase transfer to surface lateral transfer path, thus escaping confinement by the photo-Dember effect. Meanwhile, after OVs construction, each adsorbed N 2 molecule simultaneously bonds with three Bi atoms of material through N 2p–Bi 6p bonding, accelerating the filling of high-energy electrons into the π* orbital of N 2 , leading to a new nitrogen reduction path with combined alternating hydrogenation and terminal hydrogenation. This study greatly advances the beneficial effect of charge carrier migration through overcoming the photo-Dember effect for ammonia synthesis.}, archive = {J_ANGEW}, author = {Peishen Li and Yixuan Gao and Alistair G. L. Borthwick and Panpan Li and Huixuan Zhang and Fangyuan Chen and Long Chen and Fan Li and Wen Liu}, doi = {10.1002/anie.202503097}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503097}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic nitrogen reduction for ammonia synthesis accelerated by overcoming photo-dember effect}, volume = {64}, year = {2025}, }
• (2025). An autonomously liquefied hydrogel adhesive for programmable bioelectronic interface. ANGEW, 64(26), e202503010. (www)

  @article{ , abstract = {Hydrogel adhesives have many important applications in the fields of drug delivery, regenerative medicine, and bioelectronics. The detachment of hydrogel adhesives under the benign conditions is vital to the definitive surgical repair and implanted devices. Although stimuli-mediated detachment of hydrogel adhesives has been achieved, it is still a grand challenge to develop a transient adhesive with programmable adhesion and autonomous detachment from the substrate, especially the hairy skins. Here, we report a transient hydrogel adhesive driven by antagonistic enzyme reaction networks for programmable bioelectronic interface. The transient hydrogel shows tunable mechanical properties, adjustable adhesive strength, and autonomous sol-gel-sol transition with a programmable lifetime. Moreover, the transient hydrogel adhesive enables conformable and stable adhesion to various materials. In particular, the bioelectrode coated by the transient hydrogel adhesive allows to record stable and high-quality electromyogram, electrocardiogram, and electroencephalogram signals directly on the hairy skins without hair shaving. Notably, the autonomous liquefication of the hydrogel adhesives enables the easy removal of bioelectrode from hairy skins after usage without any noticeable damages to the hairy skins and electrode. This work paves a new avenue in the innovative development of hydrogel adhesives for the conformable and detachable bioelectronic interface.}, archive = {J_ANGEW}, author = {Mengyuan Li and Gongwei Tian and Xuemei Jiang and Dianpeng Qi and Bai Yang and Yunfeng Li}, doi = {10.1002/anie.202503010}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503010}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An autonomously liquefied hydrogel adhesive for programmable bioelectronic interface}, volume = {64}, year = {2025}, }
• (2025). Optimizing molecular packing and interfacial contact via halogenated N-glycidyl carbazole small molecules for low energy loss and highly efficient inverted perovskite solar cells. ANGEW, 64(26), e202503008. (www)

  @article{ , abstract = {Nonideal interfacial contact and non-radiative voltage loss in self-assembled monolayers (SAMs)-based inverted perovskite solar cells (PSCs) limit their further development. Herein, two carbazole-based molecules with different halogen atoms (X-OCZ, X = Cl or Br) are developed as efficient interfacial regulators. The halogen effect not only finely modulates the molecular packing, crystallinity, and surface contact potential of the MeO-2PACz analogue via self-induced intermolecular interactions but also significantly influences the subsequent crystal growth of perovskite, thus resulting in the formation of high-quality films with enhanced crystallinity, improved energy level alignment, and depressed non-radiative recombination. Importantly, the Cl-OCZ-mediated device exhibits a minimal interfacial carrier transport energy barrier of 0.10 eV and an impressive charge collection efficiency of 93.6%. Moreover, the target device (aperture area: 0.09 cm 2 ) shows an exceptional efficiency of 26.57% (certified 26.4%) along with enhanced thermal and operational stability. The strategy is also extended to large area devices, delivering efficiencies of 25.0% for a 1 cm 2 device and 22.9% for a 12.96 cm 2 minimodule. This study highlights the halogen role of interfacial small molecules in optimizing molecular packing and interfacial contact toward highly efficient PSCs with minimized energy loss and non-radiative recombination.}, archive = {J_ANGEW}, author = {Zhilu Xu and Xiaokang Sun and Wei Hui and Qi Wang and Ping Xu and Weijian Tang and Hanlin Hu and Lin Song and Xiaopeng Xu and Yihui Wu and Qiang Peng}, doi = {10.1002/anie.202503008}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202503008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimizing molecular packing and interfacial contact via halogenated N-glycidyl carbazole small molecules for low energy loss and highly efficient inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Why does the performance of nitrogen-doped carbon electrocatalysts decrease in acidic conditions?. ANGEW, 64(26), e202502702. (www)

  @article{ , abstract = {Nitrogen-doped carbon has emerged as a promising low-cost and durable alternative to platinum catalysts for the oxygen reduction reaction (ORR) in fuel cells. However, its catalytic activity decreases significantly in acidic electrolytes, limiting the practical applications. Here, we report the degradation mechanisms of nitrogen-doped carbon catalysts, focusing on the acid-base equilibrium of pyridinic nitrogen (pyri-N), which serves the primary active site. We found that the electrochemical hydrogenation of pyri-N to pyri-NH, coupled with oxygen adsorption, is a critical process. Although this reaction occurs at higher potentials in basic electrolytes, it shifts to lower potentials in acidic environments due to the protonation and stabilization of pyri-N. These results demonstrate that the decrease of the catalytic activity in acidic electrolytes is tied to the basicity of pyri-N. By controlling the basicity of pyri-N, specifically its p K a , a guideline for enhancing the ORR and other electrode reactions has been established.}, archive = {J_ANGEW}, author = {Kenji Hayashida and Junji Nakamura and Kotaro Takeyasu}, doi = {10.1002/anie.202502702}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202502702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Why does the performance of nitrogen-doped carbon electrocatalysts decrease in acidic conditions?}, volume = {64}, year = {2025}, }
• (2025). Mixing and matching of hybrid megasynthases is a hub for the evolution of metabolic diversity in cyanobacteria. ANGEW, 64(26), e202502461. (www)

  @article{ , abstract = {Modular megasynthases, such as polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), are molecular assembly lines that biosynthesize many pharmaceutically and ecologically important natural products. Understanding how these compounds evolve could inspire the artificial evolution of compound diversity by metabolic engineering. Over the past two decades, a number of seminal studies have significantly contributed to our understanding of natural product evolution. However, the evolution of NRPS and PKS assembly lines remains poorly understood, especially for NRPS/PKS hybrids. Here, we provide substantial evidence for a remarkable cluster-mixing event involving three cyanobacterial biosynthetic gene clusters (BGCs), resulting in the emergence of novel peptide-polyketide hybrids that were named minutumamides. By combining retro-evolutionary analysis with structure-guided genome mining, we could discover a potential evolutionary ancestor that links nostopeptolide and minutumamide biosynthesis. In addition, we were able to trace nostopeptolide-related module and domain blocks in various other biosynthetic pathways, indicating a surprisingly vivid mixing and matching of biosynthesis genes in the evolution of NRPS and cis -acyltransferase PKS/NRPS pathways, which was previously regarded as a unique feature of trans -acyltransferase ( trans -AT) PKS. These remarkable insights into the evolutionary plasticity of NRPS-PKS assembly lines provide valuable guidance for pathway engineers looking for productive combinations that yield “nonnatural” hybrid natural products.}, archive = {J_ANGEW}, author = {Keishi Ishida and Qi Sun and Jonna Teikari and Christian Hertweck and Elke Dittmann and Masahiro Murakami and Martin Baunach}, doi = {10.1002/anie.202502461}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202502461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mixing and matching of hybrid megasynthases is a hub for the evolution of metabolic diversity in cyanobacteria}, volume = {64}, year = {2025}, }
• (2025). Cyclization polymerization of elemental sulfur and diisocyanate: New polymerization toward high-performance polymer. ANGEW, 64(26), e202502207. (www)

  @article{ , abstract = {The development of polymer materials heavily relies on new polymerization reactions. Herein, we report the discovery of cyclization polymerization of element sulfur (S 8 ) and aliphatic diisocyanate at room temperature with 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) organic base as the catalyst, where the two monomers are covalently linked via the formation of thiadiazolidinone (TDZD) or a cyclic isocyanurate ring. The polymer of S 8 and 1,6-diisocyanatohexane (HDI) exhibits remarkable thermal stability and mechanical properties. Particularly, it has exceptionally high adhesion to various substrates in air or under water, e.g., the underwater adhesion strength is as high as ∼26.5 MPa for poly(ethylene glycol-co-1,4-cyclohexanedimethanol terephthalate) (PETG) and ∼2.3 MPa for poly(tetrafluoroethylene) (Teflon). The cyclization polymerization provides the basis for the synthesis of high-performance polymers with elemental sulfur.}, archive = {J_ANGEW}, author = {Jikai Zhang and Yongkang Zuo and Hongxin Yao and Jianwei Zhang and Wenyan Huang and Hongjun Yang and Guangzhao Zhang}, doi = {10.1002/anie.202502207}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202502207}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyclization polymerization of elemental sulfur and diisocyanate: New polymerization toward high-performance polymer}, volume = {64}, year = {2025}, }
• (2025). Solid–Liquid interfacial hydrogen bond-mediated mass transfer toward industrial water electrolysis. ANGEW, 64(26), e202502151. (www)

  @article{ , abstract = {The rapid migration of reactive ions across the electrolyte–catalytic sites interface is crucial in various catalytic processes. Herein, we introduce hydrogen bonds to bridge the intrinsic gap at the catalyst–electrolyte interface, mediating the diffusion of hydroxide ions. We implemented the aforementioned concept by a library of oxyanions functionalized NiCo OOH, wherein the oxygen atom within the oxyanions established hydrogen bonds with H 2 O molecules in the electrolyte. Operando spectroscopy indicated that both water electrolysis activity and hydroxide concentration exhibited a volcano-shaped dependence on the electrostatic potential of functionalized group, which formulated the electrostatic potential as descriptors to guide the design of interfacial hydrogen bond-mediated catalysis. The sulfate-modified NiCo OOH achieved an ultralow energy consumption of 4.23 kWh m −3 H2 in the industrial electrolyzers, predicting that the electricity consumption can be reduced by 16 000 TWh.}, archive = {J_ANGEW}, author = {Yu Lin and Bowen Chen and Danji Huang and Zhenhong Yang and Ang Lu and Zhaoyang Shi and Youwen Liu and Jiakun Fang and Huiqiao Li and Tianyou Zhai}, doi = {10.1002/anie.202502151}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202502151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solid–Liquid interfacial hydrogen bond-mediated mass transfer toward industrial water electrolysis}, volume = {64}, year = {2025}, }
• (2025). A general strategy for enhanced single-molecule imaging through intramolecular energy transfer. ANGEW, 64(26), e202502112. (www)

  @article{ , abstract = {Single-molecule imaging demands fluorophores with exceptional photostability and photon budget. This study presents an intramolecular energy transfer (IMET) strategy to enhance these critical properties. We developed xanthene-based IMET cassettes by covalently linking donor and acceptor, achieving significant improvements in single-molecule imaging performance. While extensive spectral overlap is generally beneficial in bulk systems, single-molecule imaging necessitates careful optimization to minimize direct acceptor excitation at the high excitation powers typically used. Our optimized cassettes, featuring rhodamine as donor and Si-rhodamine as acceptor, exhibit 94.8% energy transfer efficiency. This configuration effectively minimizes direct excitation-induced acceptor bleaching, as 94.9% of molecules exhibit donor photobleaching prior to acceptor photobleaching. This efficient energy management leads to a 670% enhancement in photostability, arising from the competition between IMET and photobleaching pathways, which effectively channels excitation energy away from photo-destructive processes. Time-resolved transient absorption spectroscopy revealed that IMET occurs on a picosecond timescale, significantly faster than both fluorescence relaxation (nanoseconds) and photobleaching (seconds). Notably, these IMET cassettes demonstrated superior performance in single-molecule tracking applications, including on supported lipid bilayers and in live-cell tracking of epidermal growth factor receptor (EGFR) dynamics, highlighting the broad potential of the IMET strategy for advancing single-molecule imaging.}, archive = {J_ANGEW}, author = {Song Chen and Fan Ding and Chang Liu and Lu Yang and Yankun Lu and Yunxiang Zhang and Qian Liu}, doi = {10.1002/anie.202502112}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202502112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A general strategy for enhanced single-molecule imaging through intramolecular energy transfer}, volume = {64}, year = {2025}, }
• (2025). Modulating electron transfer via cerium photocatalysis for alkoxy radical-mediated selective hydroetherification. ANGEW, 64(26), e202501949. (www)

  @article{ , abstract = {We present a ligand-to-metal charge transfer (LMCT)-enabled catalytic platform utilizing cerium(IV) benzoate complexes to address the long-standing challenge of directly coupling free alcohols with electron-rich alkenes, overcoming inherent polarity mismatches. This approach effectively circumvents the typical selectivity in single-electron transfer processes, enabling the selective generation of electrophilic alkoxy radicals from free alcohols in the presence of redox-labile electron-rich alkenes. The Ce-benzoate-based photocatalytic protocol promotes regioselective hydroetherification via both intramolecular cyclization and intermolecular addition pathways, showcasing broad functional group tolerance, operational simplicity, and versatility across a diverse array of alkenes, including silyl enol ethers and enamides/enecarbamates. Detailed mechanistic studies elucidate the structure of the active Ce(IV) benzoate catalyst, highlighting its unique selectivity for alkoxy radical generation, thereby establishing a practical and atom-economical framework for hydroetherification.}, archive = {J_ANGEW}, author = {Peng Li and Lingfei Duan and Yunzhi Lin and Lingling Chu and Zhiwei Zuo}, doi = {10.1002/anie.202501949}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202501949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating electron transfer via cerium photocatalysis for alkoxy radical-mediated selective hydroetherification}, volume = {64}, year = {2025}, }
• (2025). Histidine-based “Transfer stations” at carbon-immobilized metal particles enable rapid hydrogen transfer for efficient formic acid dehydrogenation. ANGEW, 64(26), e202501836. (www)

  @article{ , abstract = {The interaction of surface metal species with the solution plays a key role in engineering heterogeneous catalytic processes. Herein, we present the facile synthesis of L-histidine-coordinated PdAg nanoparticles (4.03 ± 0.08 nm) anchored on pristine carbon supports (denoted as PdAg-NH 2 /C) and their use for formic acid dehydrogenation (FAD). Significant acceleration of FAD related to the histidine is observed, and the enhancement mechanism is experimentally and theoretically investigated. The presence of L-histidine at metal sites promotes rapid binding of formic acid molecules due to acid–base interactions. The local enrichment of both protons and formate at the metal-solution interfaces promotes the subsequent formate decomposition and hydride transfer to the metal surface. The as-generated surface H species are more concentrated compared to the previously reported catalyst where the metal is loaded on an amino modified support, this enabling a significantly enhanced H 2 production. The optimal Pd 1 Ag 1 -NH 2 /C catalyst exhibits a high turnover frequency (TOF) of 6493.5 h −1 at 333 K based on the total amount of Pd, together with an H 2 selectivity of 100%. This study emphasizes the critical role of optimizing local transport pathways near catalytic centers chemically and further provides insights into the rational development of heterogeneous catalysts for FAD technologies.}, archive = {J_ANGEW}, author = {Zhenyi Yang and Guoyu Hou and Nana Gao and Yicheng Li and Xingqiu Li and Zitao Chen and Haibao Jin and Ming Zhao and Dongyang Wang and Ke Chen and Markus Antonietti and Tianxi Liu and Zhihong Tian and Yu Zhang}, doi = {10.1002/anie.202501836}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202501836}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Histidine-based “Transfer stations” at carbon-immobilized metal particles enable rapid hydrogen transfer for efficient formic acid dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Tuning multi-active sites in cu catalyst via Ag/Ni doping for enhanced CO2 electroreduction to c2+ products. ANGEW, 64(26), e202501833. (www)

  @article{ , abstract = {Electrochemical CO 2 reduction (ECR) to C 2+ products is a promising sustainable carbon conversion pathway, yet simultaneously achieving high Faradaic efficiency (FE) and current density remains a challenge. Herein, we found that creating Cu-Ag-Ni multi-metal sites could effectively modulate the adsorption energies of *H and *CO on the catalyst surface, thereby achieving highly efficient ECR to synthesize C 2+ products. In situ measurements coupling theoretical calculations indicated that by systematically altering the spatial arrangement and distribution of active sites in Cu-Ag-Ni catalysts, the electronic structure and the local *CO coverage on the Cu surface could be tuned, consequently steering the ECR to C 2+ pathway. In particular, Cu-Ag-Ni catalyst with dispersed multi-sites (Cu x AgNi DNPs) could more effectively reduce the energy barrier for C─C coupling than Cu-Ag-Ni catalyst with phase-separated multi-sites (Cu x AgNi PNPs). As a result, the Cu 40 AgNi DNPs catalyst with dispersed multi-sites yielded C 2+ products with a FE of 93.2% and a current density up to 818.1 mA cm −2 at −1.38 V versus reversible hydrogen electrode (vs. RHE), which are higher than most reported up to date for C 2+ production. This work provides a methodology for designing robust multi-metallic ECR catalysts with tailored multi-active site configurations.}, archive = {J_ANGEW}, author = {Shuaiqiang Jia and Hailian Cheng and Qinggong Zhu and Xiao Chen and Cheng Xue and Ting Deng and Mengke Dong and Zhanghui Xia and Jiapeng Jiao and Chunjun Chen and Haihong Wu and Mingyuan He and Buxing Han}, doi = {10.1002/anie.202501833}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202501833}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning multi-active sites in cu catalyst via Ag/Ni doping for enhanced CO2 electroreduction to c2+ products}, volume = {64}, year = {2025}, }
• (2025). Construction of nonadjacent stereocenters through iridium-catalyzed desymmetric hydroheteroarylation of cyclopentenes. ANGEW, 64(26), e202501641. (www)

  @article{ , abstract = {Transition metal–catalyzed direct addition of (hetero)aryl C─H bond to an alkene provides an expedited route to construct benzylic stereocenter from readily available arene and alkene feedstocks with complete atom-economy. However, creation of more than one stereocenter through enantioselective C─H (hetero)arylation remains a challenging goal. Here we report an iridium-catalyzed desymmetric hydroheteroarylation of cyclopentenes to construct 1,3-nonadjacent stereocenters. A series of heteroaryl C─H bonds were cleaved site-selectively and added regio- and enantioselectively to an unactivated alkene containing an amide coordinating group, delivering valuable enantioenriched cyclopentane scaffolds containing 1,3-tertiary–tertiary or 1,3-quaternary–tertiary stereocenters with exclusive diastereoselectivity and excellent enantioselectivity.}, archive = {J_ANGEW}, author = {En-Ze Lin and Wei Zhao and Jun-Kai Shi and Yu-Wen Sun and Xianrui Xiong and Xiaotian Qi and Xin Sun and Bi-Jie Li}, doi = {10.1002/anie.202501641}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202501641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of nonadjacent stereocenters through iridium-catalyzed desymmetric hydroheteroarylation of cyclopentenes}, volume = {64}, year = {2025}, }
• (2025). Identification of an activity selector for the nitroso-forming activity in bacterial type-III copper enzymes. ANGEW, 64(26), e202501560. (www)

  @article{ , abstract = {O -aminophenol oxidases, a specialized subclass of type-III copper proteins, play a crucial role in the biosynthesis of bioactive nitrosophenols, which display antiretroviral and blood cholesterol-lowering activity. Another related subclass of type-III copper proteins, tyrosinases, closely resemble o -aminophenol oxidases structurally and enzymatically but lack their unique ability to oxidize o -aminophenols into nitrosophenols. To unpuzzle the catalytic disparities of both subclasses, highly conserved amino acid residues in the vicinity of the catalytic center were identified. Notably, the Asn43 residue in the o -aminophenol oxidase from Streptomyces griseus ( Sg GriF) plays a pivotal role in its nitroso-forming activity. Mutating the Asn43 residue in Sg GriF to isoleucine, which is present at the homologous position Ile42 in the tyrosinase from Streptomyces sp. ZL-24 ( Sz TYR), resulted in the loss of the nitroso-forming activity in Sg GriF. Conversely, exchanging Ile42 in Sz TYR to asparagine generates nitroso-forming activity in Sz TYR. The results presented herein demonstrate the feasibility of converting an o -aminophenol oxidase into a tyrosinase and vice versa through a single amino acid mutation, underscoring the potential of these findings for future applications in medicinal and material sciences.}, archive = {J_ANGEW}, author = {Hoa Le Xuan and Felix Panis and Annette Rompel}, doi = {10.1002/anie.202501560}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202501560}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identification of an activity selector for the nitroso-forming activity in bacterial type-III copper enzymes}, volume = {64}, year = {2025}, }
• (2025). Porous aromatic frameworks filler with anion-constrained centers in composite polymer electrolyte for lithium-ion batteries. ANGEW, 64(26), e202501412. (www)

  @article{ , abstract = {The widespread use of lithium-ion batteries (LIBs) based on solid polymer electrolytes (SPEs) is hindered by their low Li + conductivity and safety risks posed by the growth of lithium dendrites. To overcome the aforementioned challenges, we designed a cationic porous aromatic framework (PAF-142) and introduced it as a filler into SPEs to obtain a composite polymer electrolyte (CPE), PAF-142-CPE. The cationic imidazolium sites could effectively constrain the movement of anions through electrostatic interactions. Furthermore, the design of the imidazolium-based building units allowed the cationic sites to be located within the framework, which promoted the transport of Li + . Density functional theory (DFT) and molecular dynamics simulations revealed the mechanism by which PAF-142 promoted the dissociation of lithium salts and enhanced Li + transport. Benefiting from these advantages, the Li + conductivity of quasi-solid composite polymer electrolyte (QCPE), PAF-142-QCPE reached 8.77 × 10 −4 S cm −1 at 20 °C. Additionally, a stable interface with abundant inorganic components was formed between PAF-142-QCPE and the lithium electrode, thus effectively inhibiting the growth of lithium dendrites, thereby achieving stable long cycle of the Li//PAF-142-QCPE//Li cell for more than 8500 h. The Li//PAF-142-QCPE//LFP cell demonstrated excellent cycle life exceeding 1400 cycles. This study proposes a promising SPEs performance-enhancing solution, advancing cutting-edge lithium-ion batteries.}, archive = {J_ANGEW}, author = {Tingting Ma and Bin Fu and Hua Feng and Yunxuan Li and Yuhui Zhai and Yuyang Tian and Zhangnan Li and Zhong-Min Su}, doi = {10.1002/anie.202501412}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202501412}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porous aromatic frameworks filler with anion-constrained centers in composite polymer electrolyte for lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Machine-learning-driven exploration of surface reconstructions of reduced rutile TiO2. ANGEW, 64(26), e202501017. (www)

  @article{ , abstract = {Titanium dioxide (TiO 2 ) is widely used as a catalyst support due to its stability, tunable electronic properties, and surface oxygen vacancies, which are crucial for catalytic processes such as the reverse water-gas shift (RWGS) reaction. Reduced TiO 2 surfaces undergo complex surface reconstructions that endow unique properties but are computationally challenging to describe. In this study, we utilize machine-learning interatomic potentials (MLIPs) integrated with an active-learning workflow to efficiently explore reduced rutile TiO 2 surfaces. This approach enabled the prediction of a phase diagram as a function of oxygen chemical potential, revealing a variety of reconstructed phases, including a previously unreported subsurface shear plane structure. We further investigate the electronic properties of these surfaces and validate our results by comparing experimental and theoretical high-resolution transmission electron microscopy (HRTEM). Our findings provide new insights into how extreme surface reductions influence the structural and electronic properties of TiO 2 , with potential implications for catalyst design.}, archive = {J_ANGEW}, author = {Yonghyuk Lee and Xiaobo Chen and Sabrina M. Gericke and Meng Li and Dmitri N. Zakharov and Ashley R. Head and Judith C. Yang and Anastassia N. Alexandrova}, doi = {10.1002/anie.202501017}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202501017}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine-learning-driven exploration of surface reconstructions of reduced rutile TiO2}, volume = {64}, year = {2025}, }
• (2025). Surface chemistry of WC powder electrocatalysts probed in situ with NAP-XPS. ANGEW, 64(26), e202500965. (www)

  @article{ , abstract = {Tungsten carbide (WC) is a renowned compound catalyst material for electrochemical water splitting, and its high electrocatalytic activity toward the hydrogen evolution reaction (HER) has been repeatedly reported. However, its susceptibility to oxidation raises the fundamental question of the underlying reason for its high activity, especially since passivation and thus potential deactivation can occur not only in air but also during reaction. Hence, the investigation of the surface chemistry under true operating conditions is crucial for a fundamental understanding of the electrocatalytic process. In this work, we use electrochemical X-ray photoelectron spectroscopy (EC-XPS) to revisit the surface chemistry of WC powder electrodes in alkaline electrolyte in situ and under full potential control. Our results show that although the surface is initially covered with oxide, this passive film dissolves in the electrolyte under electrochemical reaction conditions. This clarifies the active surface termination during the HER and highlights the potential of laboratory-based EC-XPS to study applied energy conversion materials.}, archive = {J_ANGEW}, author = {Christoph Griesser and Sergio Diaz-Coello and Matteo Olgiati and Wanderson Ferraz do Valle and Toni Moser and Andrea Auer and Elena Pastor and Markus Valtiner and Julia Kunze Liebhäuser}, doi = {10.1002/anie.202500965}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202500965}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface chemistry of WC powder electrocatalysts probed in situ with NAP-XPS}, volume = {64}, year = {2025}, }
• (2025). Uncovering the photochemical conversion of atmospheric chlorinated organics on mineral dust: In-field evidence of a new source of dioxin. ANGEW, 64(26), e202500854. (www)

  @article{ , abstract = {Hazardous chemicals are typically assessed based on their inherent toxicity, often neglecting the fact that their atmospheric secondary transformation products may exhibit increased toxicity and persistence, potentially exceeding the risks associated with the parent chemicals. Chlorinated volatile organic compounds (CVOCs) are a significant class of commercial chemicals, but their secondary conversion in the atmosphere remains largely unknown. Herein, by combining laboratory and in-field experiments, we have identified a new conversion pathway that the CVOCs can be photochemically transformed into polychlorinated dibenzo- p -dioxins and dibenzofurans (PCDD/Fs) on mineral dust particulates under atmospheric conditions. We showed that mineral components, particularly Fe- and Al-related oxides, can efficiently convert monochlorobenzene, dichloromethane, and perchloroethylene into PCDD/Fs under light irradiation. By combing reaction product measurements and density functional theory (DFT) calculations, we found that the α-Fe 2 O 3 exhibited much higher propensity for dioxin formation than γ-Al 2 O 3 , as evidenced by its lower reaction energy barriers for both the initial phenol formation and subsequent chlorination processes. In particular, histopathological assays showed the photochemically-reacted α-Fe 2 O 3 can cause severe damage to the lung and brain tissues of mice, underscoring the need to reassess the toxicity of commercial CVOCs and their secondary transformation products.}, archive = {J_ANGEW}, author = {Meiling Chen and Yumin Mao and Mengjie Yin and Yunpeng Long and Jingfeng Ding and Zhibin Wang and Kezhou Liu and Lizhi Zhang and Zhongbiao Wu and Xiaole Weng}, doi = {10.1002/anie.202500854}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202500854}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Uncovering the photochemical conversion of atmospheric chlorinated organics on mineral dust: In-field evidence of a new source of dioxin}, volume = {64}, year = {2025}, }
• (2025). Thionated perylenebisimides as heavy-atom-free triplet photosensitizers: Intersystem crossing, electron spin dynamics, and application in photodynamic therapy. ANGEW, 64(26), e202500718. (www)

  @article{ , abstract = {The thionation induced intersystem crossing (ISC) in perylenebisimide (PBI) derivatives was studied. The triplet state lifetimes of the thionated PBIs are substantially shortened (0.12–0.78 µs) as compared to the unsubstituted PBI (ca. 130 µs). Moreover, there is a clear trend of shortening of the triplet excited state lifetimes and the degree of thionation of the carbonyl groups in PBI. These findings rationalize the previous report of the contradictory lower 1 O 2 quantum yields for the PBI derivatives with more carbonyl groups thionated. Time-resolved electron paramagnetic resonance (TREPR) spectral study shows that the zero field splitting parameters D (1625–1992 MHz) of the lowest triplet states of thionated PBI are larger than that of the pristine PBI chromophore ( D = 1166 MHz), which is attributed to the influence of sulfur atoms. Interestingly, the electron spin polarization (ESP) pattern of the TREPR spectra is inverted at longer delay time. Importantly we observed ISC for the dianion of the thionated PBI derivatives, and photoexcited dianion species can be used as super strong reductant for photocatalysis with the advantage of long excited state lifetimes (18–85 µs), and the excited state oxidation potentials are −1.47 to −1.77 V (versus Fc/Fc + ).}, archive = {J_ANGEW}, author = {Xi Chen and Ivan V. Kurganskii and Zhiyong Zhuang and Yue He and Noreen Rehmat and Zafar Mahmood and Jianzhang Zhao and Matvey V. Fedin and Liang Luo and Daniel Escudero and Bernhard Dick}, doi = {10.1002/anie.202500718}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202500718}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thionated perylenebisimides as heavy-atom-free triplet photosensitizers: Intersystem crossing, electron spin dynamics, and application in photodynamic therapy}, volume = {64}, year = {2025}, }
• (2025). Evaluation of intermolecular weak binding through the zero-field splitting of an endofullerene high-spin probe. ANGEW, 64(26), e202500662. (www)

  @article{ , abstract = {Weak binding between molecules is becoming a renowned aspect of molecular engineering, offering an alternative to the tuning of conventional chemical bonds. However, the subtle nature of these interactions poses challenges for characterization using standard techniques. Herein, an efficient method of weak binding characterization based on the zero-field splitting of a high-spin probe by electron paramagnetic resonance is presented. Using endofullerene as the high spin center, we achieved direct comparison of the weak binding strengths in F-MTPP (M = H 2 , Zn, Ni, and Pd) and 2F-3MTPP (M = H 2 , Ni, Pd, and Pt) through the zero-field splitting parameters. The high-spin resonance spectrum is sensitive to the small variation in the supramolecular structure. By examining fullerene–porphyrin co-crystals with various metal centers and packing arrangements, the relation between intermolecular weak binding and microstructural strain on the fullerene cage is elucidated.}, archive = {J_ANGEW}, author = {Qi Xiong and Jia-Yue Yuan and You-Chao Liu and Yao-Sheng Zhang and Zhi-Rong Wu and Xing-Quan Tao and Cong-Hui Wu and Xin-Yu Hui and Song Gao and Ye-Xin Wang and Shen Zhou and Shang-Da Jiang}, doi = {10.1002/anie.202500662}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202500662}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evaluation of intermolecular weak binding through the zero-field splitting of an endofullerene high-spin probe}, volume = {64}, year = {2025}, }
• (2025). A C–H arylation-based enantioselective synthesis of planar chiral cyclophanes. ANGEW, 64(26), e202500653. (www)

  @article{ , abstract = {Despite the growing importance of planar chiral macrocyclophanes owing to their unique properties in different areas of chemistry, methods that are effective in controlling their planar chirality are restricted to certain molecular scaffolds. Herein, we report the first Pd(0)-catalyzed enantioselective intermolecular C−H arylation that induces planar chirality by installing bulky aryl groups through dynamic kinetic resolution (DKR). A computer-assisted approach allowed a fine-tuning of the structure of the employed chiral bifunctional phosphine-carboxylate ligands to achieve high enantioselectivities. A range of planar chiral macrocyclophanes were successfully synthesized from configurationally labile macrocyclic precursors via C−H arylation with various perfluoroarenes. Mechanistic investigations indicated that the reaction proceeds via reversible oxidative addition and enantiodetermining C−H activation. Selected macrocyclophane products showed interesting photophysical and chiroptical properties, which depended on both the nature of the ansa chains and the aromatic moieties.}, archive = {J_ANGEW}, author = {Soohee Huh and Elvira Linne and Lilian Estaque and Grégory Pieters and Michael Devereux and Olivier Baudoin}, doi = {10.1002/anie.202500653}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202500653}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A C–H arylation-based enantioselective synthesis of planar chiral cyclophanes}, volume = {64}, year = {2025}, }
• (2025). Au147(SPh)30(PPh3)12: A geometrically closed, but electronically open triple-shell icosahedral gold cluster and its geometrically open counterpart. ANGEW, 64(26), e202500586. (www)

  @article{ , abstract = {The aesthetic platonic solids have been known since ancient times, and the structure of all five platonic solids is also found in chemical compounds. While gold sub-nanometer clusters and gold nanoparticles with an icosahedral structure have been known for a long time to exist, a multi-shell icosahedral gold cluster at the intermediate size between 13 and thousands of atoms has been elusive. Here we present the synthesis and crystallographic characterization of the first triple-shell icosahedral metal cluster, Au 147 (SPh) 30 (PPh 3 ) 12 1 . The gold core in 1 is stabilized by phosphines and thiolates, but surprisingly no staple motifs are formed. A second cluster, Au 146 (SPh) 30 (PPh 3 ) 12 2 , cocrystallizes and is identified as having a closed electronic shell but can be considered as a geometrically open pendant of 1 . The unique clusters are characterized experimentally by EDX, UV/vis, DLS, and EPR and theoretically by quantum chemical calculations.}, archive = {J_ANGEW}, author = {Markus Strienz and Andrei Poddelskii and Bridget K. Moll and Claudio Schrenk and Phillip S. Thomas and Andre Z. Clayborne and Andreas Schnepf}, doi = {10.1002/anie.202500586}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202500586}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Au147(SPh)30(PPh3)12: A geometrically closed, but electronically open triple-shell icosahedral gold cluster and its geometrically open counterpart}, volume = {64}, year = {2025}, }
• (2025). Ribozyme-catalyzed site-specific labeling of RNA using o6-alkylguanine SNAP-tag substrates. ANGEW, 64(26), e202500257. (www)

  @article{ , abstract = {Site-specific modification of RNAs with functional handles enables studies of RNA structure, fate, function, and interactions. Ribozymes provide an elegant way to covalently modify RNA of interest (ROI). Here, we report that the methyltransferase ribozyme MTR1 can be employed as a versatile tool for RNA modification and labeling. Using O 6 -alkylguanine cofactors, designed in analogy to SNAP-tag substrates for protein labeling, MTR1 installs various bioorthogonal functional groups at N 1 of a specific adenosine in the RNA target. In this application of ribozyme-catalyzed RNA labeling, MTR1 is now called SNAPR. In contrast to the self-labeling SNAP-tag, which is appended to the protein of interest, SNAPR is a truly intermolecular RNA catalyst (active in trans). SNAPR assembles with the ROI to the active ribozyme, allowing for the transfer of clickable tags, such as azide and alkyne moieties, as well as photolabile groups or cross-linkers from the guanine cofactor to the ROI. Moreover, we demonstrate a two-step approach to attach labels at N 6 of the target adenosine: first, SNAPR generates N 1 A-modified RNA, followed by preparative Dimroth rearrangement to produce N 6 A-modified RNA. We demonstrate this strategy with p -azidobenzyl groups as photocrosslinker to generate covalent RNA–protein conjugates. Overall, this work expands the toolbox for site-specific RNA modification.}, archive = {J_ANGEW}, author = {Manisha B. Walunj and Carolin P. M. Scheitl and Tina Jungnickel and Claudia Höbartner}, doi = {10.1002/anie.202500257}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202500257}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ribozyme-catalyzed site-specific labeling of RNA using o6-alkylguanine SNAP-tag substrates}, volume = {64}, year = {2025}, }
• (2025). In quest of chemical probes for DNA methylation reader proteins: Nucleoside and dimer analogues of 5-methylcytosine interact with MBD2. ANGEW, 64(26), e202425599. (www)

  @article{ , abstract = {DNA methylation modulates gene expression without altering the DNA sequence. Aberrant DNA methylation patterns characterise a wide range of diseases, from cancer to neurological disorders, and serve as validated therapeutic targets and diagnostic tools. Among the proteins involved in DNA methylation regulation, the human reader methyl-CpG binding domain 2 protein (MBD2) exhibits a strong preference for methylated DNA and initiates signalling cascades predominantly resulting in gene repression. The full description of this mechanism is still to be elucidated. Here, we developed original chemical compounds to interfere with MBD2 and its interaction with DNA. Through convergent chemical pathways, we modified 5-methylcytosine at position N 4 and synthesised the corresponding deoxynucleosides and CpG dimers. We tested 70 compounds in two screening assays to assess their interaction with MBD2 and their ability to disrupt the MBD2/DNA complex. Remarkably, substituting modified nucleobases into CpG dimers significantly boosted the biological activity. Furthermore, we investigated the impact of the configuration ( d/l ) of the modified nucleosides and identified four dimers ( 5d , 7e , 15e and 16e ) able to disrupt the MBD2/DNA complex, highlighting the advantage of the l -configuration. Importantly, NMR experiments confirmed their interaction with amino acids of MBD2 involved in methylated DNA binding.}, archive = {J_ANGEW}, author = {Jean Contreras and Sophie Vichier-Guerre and Laurence Dugué and Frédéric Bonhomme and Corinne Jallet and Minh-Ha Nguyen and Bruno Vitorge and Alessandra Feoli and Gianluca Sbardella and J. Iñaki Guijarro and Paola B. Arimondo}, doi = {10.1002/anie.202425599}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202425599}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In quest of chemical probes for DNA methylation reader proteins: Nucleoside and dimer analogues of 5-methylcytosine interact with MBD2}, volume = {64}, year = {2025}, }
• (2025). Enantioselective abiotic synthesis of ribose on chiral mesostructured hydroxyapatite. ANGEW, 64(26), e202425581. (www)

  @article{ , abstract = {The prebiotic synthesis and symmetry breaking of ribose are crucial processes in the origin of life. However, the prebiotic emergence of enantiomerically enriched ribose on primitive Earth remains an unresolved challenge. Herein, we propose that the prebiotic enantioselective synthesis of ribose from glycolaldehyde and glyceraldehyde can be catalyzed by minerals naturally endowed with chiral structure. The chiral mesostructured hydroxyapatite films (CMHAPFs), which consist of lattice-distorted helical nanorods, can be formed under a hydrothermal condition in the presence of l/d- malic acid (MA), a compound that may have been present during the early stages of life's emergence. An enantiomeric excess ( ee ) of 22.5% for d- ribose was achieved on the d- CMHAPFs formed by d- MA. The adsorption conformation of d -ribose on the surface of right-handed hydroxyapatite is more stable than that of l -ribose. The different energy barriers for the transition states of ribose enantiomers result in the enantioselective synthesis of ribose, which is attributed to the similar conformation between ribose and the corresponding transition state. Our findings provide valuable insights into the possible role of chiral inorganics in the prebiotic synthesis and symmetry breaking of ribose.}, archive = {J_ANGEW}, author = {Wendi Zhang and Yao Wang and Yanhang Ma and Yingying Duan and Wanning Zhang and Shunai Che and Yuxi Fang}, doi = {10.1002/anie.202425581}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202425581}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective abiotic synthesis of ribose on chiral mesostructured hydroxyapatite}, volume = {64}, year = {2025}, }
• (2025). Mesoporous enhanced heterostructured halide solid electrolytes with high air stability and high abundance for sustainable sodium metal batteries. ANGEW, 64(26), e202425503. (www)

  @article{ , abstract = {Chlorides and fluorides solid-state electrolytes (SEs) exhibit contrasting extremes in ionic conductivity and moisture sensitivity. In light of these conflicting factors, we introduce a NaCl-based SE reinforced by mesoporous α-AlF 3 (denoted as HS-AlF 3 ), leading to a heterostructure halide architecture, designated as NHxy (where x/y represents the mass ratio of NaCl to HS-AlF 3 ). The high dispersion of NaCl and HS-AlF 3 during mechanochemical process enables the generation of defective and amorphous structures and nanodomains in NHxy along with F-Cl anion substitution effect at grain boundaries. These factors collectively promote Na ion transport in NHxy, especially along the NaCl based heterostructures with AlF 3 and NaF. This class of SEs achieves the high ionic conductivity approaching 10 −4 S cm −1 at 30 °C. Specifically, NH54 exhibits excellent long-term air stability at 35% relative humidity, maintaining high ion conductivity without degradation. The raw material cost of this Na-based electrolyte is less than $10 USD kg −1 when considering the production in a large scale. The corresponding Na//Na symmetric cells demonstrate the stable cycling for at least 1000 h at 0.1 mA cm − 2 . The Na//Na 3 V 2 (PO 4 ) 3 cells assembled with the NH54 after air exposure exhibit the remarkable longevity, sustaining over 400 cycles at 60 °C. The conversion-type Na/NH54/FeF 3 cells deliver a high capacity of 500 mAh g −1 . This work opens the new pathways for inorganic SEs with enhanced economic value, ion conductivity, air stability and suitability for energy-dense conversion reaction batteries.}, archive = {J_ANGEW}, author = {Qijie Yu and Jiulin Hu and Yi Xu and Runyuan Cao and Shuangqiang Chen and Chilin Li}, doi = {10.1002/anie.202425503}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202425503}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mesoporous enhanced heterostructured halide solid electrolytes with high air stability and high abundance for sustainable sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Synergistic mechanism for unconventional anodic reaction of aldehyde oxidation for hydrogen production. ANGEW, 64(26), e202425258. (www)

  @article{ , abstract = {Anodic reactions involving non-faradaic processes have significantly expanded the potential application of anodic oxidation half-reactions. Metallic Cu materials can catalyze an unconventional anodic aldehyde oxidation reaction involving the non-faradaic H 2 production (AOR-H 2 ). AOR-H 2 has distinct advantages of ultra-low thermodynamic potentials and high value-added redox products, etc., but the question of exactly how reduction steps occur during AOR-H 2 , is something which has long puzzled scientists. Here we illustrate the novel synergistic mechanism of nonelectrochemical/electrochemical redox steps in AOR-H 2 . Aldehyde undergoes hydration, deprotonation, and spontaneous C–H homolytic cleavage to generate H 2 , and then is electrochemically oxidized to form carboxylate. Decorating Cu catalysts with metallic Pt species, supported by theoretical calculations, leads to a 12-fold increase in the intrinsic activity of AOR-H 2 . This work inspires researchers to develop novel cathodic and anodic reactions involving the non-faradaic process for breaking through the limit of existing energy conversion systems.}, archive = {J_ANGEW}, author = {Wei Chen and Jiaxin Chen and Chongyang Ma and Mengwei Han and Ming Yang and Yu-Cheng Huang and Yandong Wu and Yiming Jiang and Ruiqi Wang and Tehua Wang and Ying-Rui Lu and Yuqin Zou and Shuangyin Wang}, doi = {10.1002/anie.202425258}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202425258}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic mechanism for unconventional anodic reaction of aldehyde oxidation for hydrogen production}, volume = {64}, year = {2025}, }
• (2025). Functional SELEX and biomedical applications of aptamers: Beyond molecular recognition. ANGEW, 64(26), e202424687. (www)

  @article{ , abstract = {Aptamers, developed through SELEX (systematic evolution of ligands by exponential enrichment), are generally short oligonucleotide molecules with remarkable specificity and binding affinity to diverse biological targets. These molecules have shown promise across such fields as biosensing, molecular diagnostics, and bioimaging. However, while conventional aptamer selection strategies predominantly emphasize binding affinity, they overlook the broader spectrum of potential biological functionalities. This oversight results in aptamers that frequently exhibit limited capacity for direct biological regulation. This inherent limitation in the selection process significantly constrains both the widespread application of aptamers across diverse fields and their therapeutic potential as direct drug candidates. Functional SELEX represents an advancement by refining selection library construction and selection processes to create F-aptamers that integrate precise molecular recognition with specific biological activities. F-aptamers hold transformative potential as therapeutic agents, diagnostic tools, and molecular regulators, marking a significant step forward in biomedical applications. This minireview critically assesses recent developments in F-aptamer SELEX strategies, addressing challenges, and exploring opportunities for future research in this dynamic field.}, archive = {J_ANGEW}, author = {Minze He and Zhimin Wang and Xiaoqiu Wu and Zhen Du and Cheng Cui and Zilong Zhao and Yang Sun and Xiao-bing Zhang and Lei He and Weihong Tan}, doi = {10.1002/anie.202424687}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202424687}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functional SELEX and biomedical applications of aptamers: Beyond molecular recognition}, volume = {64}, year = {2025}, }
• (2025). Luminescent detection of photomagnetic effect in a near-infrared emissive Neodymium(III)–Octacyanidotungstate(IV) framework. ANGEW, 64(26), e202424651. (www)

  @article{ , abstract = {Photomagnetic materials form a class of magnetic systems, in which light irradiation changes their magnetization. Photomagnetic behavior is often observed in spin transition materials, including spin-crossover complexes, and can lead to long-range magnetic ordering. Photo-induced magnetization can affect different physical properties, including second harmonic generation. Still, despite a growing number of luminescent spin-crossover systems, the simultaneous switching of both magnetism and luminescence was not yet explored. In this regard, we present systematic studies for a novel coordination polymer composed of anionic Nd III –[W IV (CN) 8 ] 4– layers, crystallizing with chiral organic cations embedded in the interlayer space. Not only we observe and rationalize theoretically near-infrared emission of Nd III centers sensitized by [W IV (CN) 8 ] 4– units, but we also found a plausible pathway to track the photomagnetic effect throughout the analysis of the Nd 3+ excitation spectra and their temperature dependence. The observed thermally reversible effects in luminescence were correlated with the results of photomagnetic studies, providing an attractive pathway to monitor the light-induced magnetization changes through a photoluminescent read-out.}, archive = {J_ANGEW}, author = {Jakub J. Zakrzewski and Robert Jankowski and Maja Romanowska and Junhao Wang and Dawid Pinkowicz and Barbara Sieklucka and Shin-ichi Ohkoshi and Szymon Chorazy}, doi = {10.1002/anie.202424651}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202424651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Luminescent detection of photomagnetic effect in a near-infrared emissive Neodymium(III)–Octacyanidotungstate(IV) framework}, volume = {64}, year = {2025}, }
• (2025). Guideline for analysis and prevention of contamination catalysis. ANGEW, 64(26), e202424425. (www)

  @article{ , abstract = {Over the last decades, numerous efforts have been made to replace metal catalysts with cheaper and earth-abundant alternatives or to completely exclude metals from cross-coupling reactions while maintaining high efficiency in the target transformation. However, follow-up studies often revealed the role of metal impurities in the catalytic process. Thus, active metal impurities can lead to mechanistic misinterpretations, and these could initiate erroneous research directives and lead to severe reproducibility problems. Milestone precedents of the impurity effect in cross-coupling reactions are well documented in the literature. Interestingly, this fallacy has reoccurred repeatedly over the years due to a lack of thorough mechanistic studies and appropriate research study schemes for identifying impurity effects. Herein, we propose a guideline to elucidate the real catalyst of future catalytic transformations, aiming to reveal the correct mechanism and help exclude the role of impurities in novel catalytic processes. Although this guideline mainly focuses on problems related to trace transition metals, it also offers the basis for more general catalyst research.}, archive = {J_ANGEW}, author = {János Daru and Zsombor Gonda and Zoltán May and Zoltán Novák and Gergely L. Tolnai}, doi = {10.1002/anie.202424425}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202424425}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Guideline for analysis and prevention of contamination catalysis}, volume = {64}, year = {2025}, }
• (2025). Engineered biocatalyst for enantioselective hydrazone reduction. ANGEW, 64(26), e202424350. (www)

  @article{ , abstract = {Enantioselective reduction of hydrazones provides a convergent and versatile route to synthesize hydrazine-containing motifs that are commonly found in pharmaceuticals and agrochemicals. However, current methods require the use of precious metals, costly chiral ligands, and/or forcing reaction conditions. Here, we report the development of a biocatalytic approach for enantioselective hydrazone reduction using engineered imine reductases. Following evaluation of an in-house panel of >400 IRED sequences, we identified a single IR361 I127F L179V variant that promotes reduction of Cbz-protected hydrazones. The introduction of additional two mutations via directed evolution afforded HRED1.1 that is 20-fold more active than the parent template and promotes reduction of a variety of protected hydrazones in high yields and selectivities (>99% e.e .), including in preparative scale biotransformations. Structural analysis of HRED1.1 provides insights into the origins of its unique hydrazone reductase activity. This study offers a powerful biocatalytic route to synthesize valuable chiral hydrazine products and further expands the impressive range of transformations accessible with engineered imine reductases.}, archive = {J_ANGEW}, author = {Amy E. Hutton and Fei Zhao and Elizabeth Ho and Jack Domenech and Vanessa Harawa and Murray J. B. Brown and Gideon Grogan and Phillip D. Clayman and Nicholas J. Turner and Anthony P. Green}, doi = {10.1002/anie.202424350}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202424350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered biocatalyst for enantioselective hydrazone reduction}, volume = {64}, year = {2025}, }
• (2025). Spatio-temporal processes of diffusion-controlled communication in hierarchical multi-compartments. ANGEW, 64(26), e202424133. (www)

  @article{ , abstract = {Exploring the synergy of feedback behavior and molecular communication between micro- and nanocompartments is of great implication for the development of advanced hierarchical living-like materials. Non-covalent interactions are the driving forces for dynamic and temporal events in biomimetic structures. Herein, pH-responsive hierarchical multi-compartments (HMC) are constructed via hydrophobic–hydrophobic interactions between azobenzene units and phospholipid layers through the integration of two distinct structural units: phospholipid-membranized coacervates (Coa@DMPC) and azobenzene-functionalized polymersomes (Azo-Psomes). This enables us to study spatio-temporal signal pathways for biomimetic pH homeostasis and the triggering of feedback-controlled peroxidase-like behavior of Azo-Psomes within HMC. Compared with undocking systems, the information transmission process within HMC shows a high efficiency. Besides the continuous addition of nutrients, the synchronization of two different biomimetic reactions in HMC requires the spatial loading of glucose oxidase and L-phenylalanine ammonia lyase in coacervates and of L-phenylalanine or beta-cyclodextrin/hemin complexes in Azo-Psomes. Azo-Psomes exhibit pH-responsive feedback-controlled behavior. The pH-responsive membrane of Azo-Psomes is responsible for the spatio-temporal peroxidase-like activity of lumen-integrated beta-cyclodextrin/hemin complexes in Azo-Psomes. Finally, this strategy provides a new approach for constructing more complex biomimetic systems by interconnecting at least two membrane-containing compartments to further explore the synergistic mechanisms and feedback behaviors among artificial cell communities.}, archive = {J_ANGEW}, author = {Xin Qiao and Haixu Chen and Andreas Schurig and Xiaoliang Wang and Yinyong Sun and Matthias Tobler and Susanne Boye and Kathrin Castiglione and Dietmar Appelhans and Xin Huang}, doi = {10.1002/anie.202424133}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202424133}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatio-temporal processes of diffusion-controlled communication in hierarchical multi-compartments}, volume = {64}, year = {2025}, }
• (2025). Enantiomerically enriched aziridine-2-carboxylates via copper-catalyzed reductive kinetic resolution of 2H-azirines. ANGEW, 64(26), e202423645. (www)

  @article{ , abstract = {We present the first reductive kinetic resolution of racemic 2 H -azirines to prepare optically enriched N -H aziridine-2-carboxylates, which are bench stable and readily diversifiable building blocks, concomitantly with the corresponding enantiomerically enriched 2 H -azirines. The N -H aziridines were obtained with excellent diastereoselectivity (>20:1) and high enantioselectivity (up to 94%). A Hammett study revealed a linear free energy relationship between the ΔΔG ⧧ of the diastereomeric transition states and the σ p − values. density functional theory (DFT) calculations and non-covalent interaction analysis suggested that non-classical H–bonding interactions and edge-to-face aromatic interactions between the substrate and the ligand are responsible for the stereoselectivity and also for the substrate electronic effects observed in the Hammett study.}, archive = {J_ANGEW}, author = {Yinuo Zheng and Elvis Wang Hei Ng and Antonio Rizzo and Pauline Chiu}, doi = {10.1002/anie.202423645}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202423645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantiomerically enriched aziridine-2-carboxylates via copper-catalyzed reductive kinetic resolution of 2H-azirines}, volume = {64}, year = {2025}, }
• (2025). Decoding double layer dynamics for CO2 electroreduction over cu. ANGEW, 64(26), e202423177. (www)

  @article{ , abstract = {Understanding the nature and role of the electric double layer (EDL) at electrocatalytic interfaces and its dynamic evolution, is critical to optimizing electrochemical processes such as the carbon dioxide reduction reaction ( ). Despite its postulated significant influence on activity, direct spectroscopic evidence of the complex interplay between EDL structure and reaction kinetics has remained elusive. Here, we introduce Dynamic Response Spectroscopy (DRS), a novel approach that isolates spectroscopic signatures of key physicochemical features of the EDL, including the compact (interfacial) layer and the diffuse double layer based on their time-variance profiles. By analyzing multi-dimensional time-variance within a matrix of time-resolved infrared spectral data recorded during sequential potential steps, we reveal that EDL equilibration is not continuous but involves discrete restructuring events. We provide spectroscopic evidence that these sudden EDL reorganizations correlate with the rapid adsorption and conversion of to CO. Furthermore, we show that saturation of aqueous NaHCO 3 electrolytes with , as opposed to Ar, induces more frequent and pronounced water reorientation in the diffuse double layer, characterized by less ice-like ordering and increased randomness. These findings provide novel insights into the dynamic nature of the EDL and its synergistic role in electrocatalysis, establishing a paradigm to better understand, and thus optimize, electrochemical systems.}, archive = {J_ANGEW}, author = {Daniel Sinausia and Noam Zisser and Thierry Kilian Slot and David Eisenberg and Florian Meirer and Charlotte Vogt}, doi = {10.1002/anie.202423177}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202423177}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoding double layer dynamics for CO2 electroreduction over cu}, volume = {64}, year = {2025}, }
• (2025). Intramolecular thiol-promoted decomposition of cysteine ester (ITPDC): A general platform for controllable release of reactive sulfur species. ANGEW, 64(26), e202422087. (www)

  @article{ , abstract = {Endogenously generated reactive sulfur species (RSS) play critical roles in various physiological processes. RSS donors can enhance our understanding of RSS chemical biology and open new avenues for treating RSS-associated diseases. Nevertheless, general strategies for the controllable release of distinct RSS remain lacking. Herein, we present the first general platform for controllable release of RSS with sulfur oxidation states ranging from −2 to +4, based on the intramolecular thiol-promoted decomposition of cysteine ester ( ITPDC ). We first rationally designed ITPDC -based hydrogen sulfide (H 2 S) donors that avoid electrophilic byproducts and exhibit high H 2 S release efficiencies (>50%). Mechanistic investigations and density functional theory calculations elucidated the detailed pathways of pH-controllable H 2 S release from ITPDC , and computational studies also predicted other H 2 S-related RSS release from the ITPDC -based motifs. Importantly, we developed a series of ITPDC -based donors capable of releasing various RSS, including persulfide, hydrogen persulfide, sulfenic acid, sulfinic acid, and sulfur dioxide (SO 2 ). Moreover, fluorescent imaging demonstrated the successful cellular delivery of H 2 S, persulfide, and SO 2 from these donors, and the ITPDC -based motif was employed to create a light-triggered donor. We anticipate that these innovative chemistries will provide valuable tools for studying sulfur biology and for developing new RSS donors and bio-orthogonal cleavage techniques.}, archive = {J_ANGEW}, author = {Yalun Dong and Haishun Ye and Baifan Wang and Dejun Ma and Xueying Kang and Wenfang Liang and Xuekang Cai and Shanshan Liu and Chenyang Jiang and Wenhao Du and Huatang Zhang and Hongyan Sun and Zhen Xi and Long Yi}, doi = {10.1002/anie.202422087}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202422087}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intramolecular thiol-promoted decomposition of cysteine ester (ITPDC): A general platform for controllable release of reactive sulfur species}, volume = {64}, year = {2025}, }
• (2025). Light-induced disruption of 1D wire-like arrays of monoatomic Ag(I) ions: Single-crystal reaction with crystal softening. ANGEW, 64(26), e202419875. (www)

  @article{ , abstract = {The exploitation of noncovalent bonding in the solid state is attractive to generate one-dimensional (1D) wire-like assemblies of metals and uncover dynamic and physical properties of such intriguing structures. Herein, we describe a metal-organic crystal based on Ag(I) ions that assemble to be organized into 1D wire-like assemblies maintained by argentophilic interactions. UV-light irradiation of the crystal composed of the 1D structures results in a single-crystal-to-single-crystal (SCSC) photodimerization that transforms the 1D periodic metal arrays to isolated metal dimers. The structural reconfiguration creates small voids in the crystal and the resulting solids exhibit a substantial increase in softness up to 60%.}, archive = {J_ANGEW}, author = {Changan Li and Akalanka B. Ekanayake and Qianli R. Chu and Dale C. Swenson and Alexei V. Tivanski and Leonard R. MacGillivray}, doi = {10.1002/anie.202419875}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {26}, pages = {e202419875}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-induced disruption of 1D wire-like arrays of monoatomic Ag(I) ions: Single-crystal reaction with crystal softening}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Stabilizing lattice oxygen to enable durable MnO2 electrocatalyst for simultaneous acidic hydrogen production and biomass valorization. ANGEW, 64(25), e202582501. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582501}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202582501}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Stabilizing lattice oxygen to enable durable MnO2 electrocatalyst for simultaneous acidic hydrogen production and biomass valorization}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Tandem dual-ratiometric SERS probe enables raman imaging of neurological pH fluctuations in epilepsy (Angew. chem. int. ed. 25/2025). ANGEW, 64(25), e202511457. (www)

  @article{ , archive = {J_ANGEW}, author = {Jing Zhao and Yuncan Chen and Yurui Tang and Bohan Li and Qinyue Wang and Junfeng Wang and Xihui Gao and Yunle Zhang and Jing Wang and Zuhai Lei and Cong Li and Cong Wang}, doi = {10.1002/anie.202511457}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202511457}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Tandem dual-ratiometric SERS probe enables raman imaging of neurological pH fluctuations in epilepsy (Angew. chem. int. ed. 25/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: A novel synthetic pathway to lanthanide triple-decker complexes: Selective expansion of a sandwich complex by an insertion reaction (Angew. chem. int. ed. 25/2025). ANGEW, 64(25), e202511044. (www)

  @article{ , archive = {J_ANGEW}, author = {Cedric Uhlmann and Luca Münzfeld and Adrian Hauser and Sebastian Gillhuber and Pauline Hädinger and Maxim Leskov and Florian Weigend and Peter W. Roesky}, doi = {10.1002/anie.202511044}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202511044}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: A novel synthetic pathway to lanthanide triple-decker complexes: Selective expansion of a sandwich complex by an insertion reaction (Angew. chem. int. ed. 25/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Unraveling the complexity of divalent hydride electrolytes in solid-state batteries via a data-driven framework with large language model (Angew. chem. int. ed. 25/2025). ANGEW, 64(25), e202510922. (www)

  @article{ , archive = {J_ANGEW}, author = {Qian Wang and Fangling Yang and Yuhang Wang and Di Zhang and Ryuhei Sato and Linda Zhang and Eric Jianfeng Cheng and Yigang Yan and Yungui Chen and Kazuaki Kisu and Shin-ichi Orimo and Hao Li}, doi = {10.1002/anie.202510922}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202510922}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Unraveling the complexity of divalent hydride electrolytes in solid-state batteries via a data-driven framework with large language model (Angew. chem. int. ed. 25/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Near-infrared activatable copper nanoplatforms synergize with the 5-azacytidine prodrug to potentiate cuproptosis”. ANGEW, 64(25), e202510314. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202510314}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202510314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Near-infrared activatable copper nanoplatforms synergize with the 5-azacytidine prodrug to potentiate cuproptosis”}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Indole-quinoline transmutation enabled by formal rhodium-carbynoid (Angew. chem. int. ed. 25/2025). ANGEW, 64(25), e202510007. (www)

  @article{ , archive = {J_ANGEW}, author = {Lu-Jie Liu and Meng-Yang Tian and Zhi-Yu Lang and Yong-Li Wang and Chun-Yang He and Yong-Zheng Chen and Wen-Yong Han}, doi = {10.1002/anie.202510007}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202510007}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Indole-quinoline transmutation enabled by formal rhodium-carbynoid (Angew. chem. int. ed. 25/2025)}, volume = {64}, year = {2025}, }
• (2025). Correction to “Heterostructures with built-in electric fields for long-lasting chemodynamic therapy”. ANGEW, 64(25), e202509331. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202509331}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202509331}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Heterostructures with built-in electric fields for long-lasting chemodynamic therapy”}, volume = {64}, year = {2025}, }
• (2025). Correction to “Custom-made ceria nanoparticles show a neuroprotective effect by modulating phenotypic polarization of the microglia”. ANGEW, 64(25), e202509033. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202509033}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202509033}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Custom-made ceria nanoparticles show a neuroprotective effect by modulating phenotypic polarization of the microglia”}, volume = {64}, year = {2025}, }
• (2025). Kira astakhova. ANGEW, 64(25), e202508695. (www)

  @article{ , archive = {J_ANGEW}, author = {Kira Astakhova}, doi = {10.1002/anie.202508695}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202508695}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Kira astakhova}, volume = {64}, year = {2025}, }
• (2025). Li-jun xiao. ANGEW, 64(25), e202508684. (www)

  @article{ , archive = {J_ANGEW}, author = {Li-Jun Xiao}, doi = {10.1002/anie.202508684}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202508684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Li-jun xiao}, volume = {64}, year = {2025}, }
• (2025). Core-shell structured composite solid electrolyte enables high-rate all-solid-state sodium batteries. ANGEW, 64(25), e202507247. (www)

  @article{ , abstract = {All-solid-state sodium batteries (ASSSBs) have emerged as the promising candidates for large-scale energy storage; however, they still face challenges related to ionic transport across multi-scale interfaces, which leads to suboptimal battery performances. In this study, we propose a core-shell structured composite electrolyte with Na 3 PS 4 sulfide solid electrolyte (SE) as the core and Na 2.25 Y 0.25 Zr 0.75 Cl 6 halide SE as the shell. This design strategy boosts high SE's oxidative stability (4.0 V), ionic conductivity (0.44 mS cm −1 ) and mechanical strength (Young's modulus of 9.19 GPa). These properties enable the composite SE to effectively mitigate the chemo-mechanically-induced multi-interfacial contact losses at the cathode side. Additionally, the homogeneous full-cell configuration, utilizing the core-shell structured composite electrolyte as both catholyte and SE layer, demonstrates superior rate capability, achieving a discharge capacity of 76.4 mAh g⁻¹ at 2.0 C, significantly outperforming the conventional sandwich-like designs. This work not only provides a novel design strategy for functional SE but also offers valuable insights into the chemo-mechanical failure mechanism at multiscale interfaces of ASSSBs.}, archive = {J_ANGEW}, author = {Yu Feng and Jingyi Liu and Zhixuan Wei and Shiyu Yao and Gang Chen and Fei Du}, doi = {10.1002/anie.202507247}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202507247}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Core-shell structured composite solid electrolyte enables high-rate all-solid-state sodium batteries}, volume = {64}, year = {2025}, }
• (2025). Correction to “Light enables the cathodic interface reaction reversibility in solid-state lithium-oxygen batteries”. ANGEW, 64(25), e202507211. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202507211}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202507211}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Light enables the cathodic interface reaction reversibility in solid-state lithium-oxygen batteries”}, volume = {64}, year = {2025}, }
• (2025). Visible-light-driven photocatalytic methanol activation on hexagonal CdS for triggering C─H methylation. ANGEW, 64(25), e202507093. (www)

  @article{ , abstract = {Light-driven methanol activation paves the way for pursuing C─H methylation of N -heteroarenes, where selectively converting methanol into the corresponding hydroxymethyl radical (•CH 2 OH) is an essential prerequisite. Inspired by the versatile methanol activation on photoexcited solids, we here report a practicable semiconductor-based photocatalytic system for C─H methylation of N -heteroarenes. To be specific, hexagonal cadmium sulfide ( h -CdS) was identified to be an ideal platform for visible-light-driven photocatalytic methanol activation, where selective •CH 2 OH generation undergoing a hole-transfer process without any additional co-catalysts or co-solvent could trigger C─H hydroxymethylation of N -heteroarenes. The following electron transfer between photoexcited h -CdS and hydroxymethylated intermediates could finally lead to the formation of methylated N -heteroarenes. The transformations facilitate the cascade utilization of photoinduced hole and electron, thereby endowing h -CdS with extraordinary photocatalytic performance. Besides, selective generation of hydroxymethylated/methylated product could be facilely implemented in the presence/absence of electron scavengers.}, archive = {J_ANGEW}, author = {Gang Chen and Lei Li and Yi Liu and Zhihao Li and Yanyun Hu and Hui Wang and Xiaodong Zhang and Yi Xie}, doi = {10.1002/anie.202507093}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202507093}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-light-driven photocatalytic methanol activation on hexagonal CdS for triggering C─H methylation}, volume = {64}, year = {2025}, }
• (2025). Unraveling the complexity of divalent hydride electrolytes in solid-state batteries via a data-driven framework with large language model. ANGEW, 64(25), e202506573. (www)

  @article{ , abstract = {Solid-state electrolytes (SSEs) are essential for next-generation energy storage technologies. However, the exploration of divalent hydrides is hindered by complex ionic migration mechanisms and reliance on “trial-and-error” methodologies. Conventional approaches, which focus on individual materials and predefined pathways, remain inefficient. Herein, we present a data-driven artificial intelligence framework that integrates a comprehensive SSE database with large language models and ab initio metadynamics (MetaD) simulations to accelerate the discovery of hydride SSEs. Our study reveals that hydrides incorporating neutral molecules have great potential, with MetaD revealing novel “two-step” ion migration mechanisms. Predictive models developed using both experimental and computational data accurately forecast ionic migration activation energies for various types of hydride SSEs. In particular, some SSEs with carbon-containing neutral molecules exhibit notably low activation energy, with barriers as low as 0.62 eV. This framework enables the rapid identification of optimized SSE candidates and establishes a transformative tool for advancing sustainable energy storage technologies.}, archive = {J_ANGEW}, author = {Qian Wang and Fangling Yang and Yuhang Wang and Di Zhang and Ryuhei Sato and Linda Zhang and Eric Jianfeng Cheng and Yigang Yan and Yungui Chen and Kazuaki Kisu and Shin-ichi Orimo and Hao Li}, doi = {10.1002/anie.202506573}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506573}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the complexity of divalent hydride electrolytes in solid-state batteries via a data-driven framework with large language model}, volume = {64}, year = {2025}, }
• (2025). Functionally tunable star-shaped multivalent crRNAs for photocontrol CRISPR/Cas editing. ANGEW, 64(25), e202506527. (www)

  @article{ , abstract = {Clustered regularly interspaced shortpalindromic repeats/CRISPR-associated (CRISPR/Cas)-based genome editing has significantly advanced genetic engineering due to its precision, simplicity, and versatility. However, achieving precise spatial and temporal control remains challenging, restricting therapeutic and research applications. Herein, we introduce a novel class of star-shaped, multivalent crRNAs engineered for precise spatiotemporal control of CRISPR/Cas9 and Cas12a editing systems. These crRNAs are synthesized via single-site chemical modification and can be efficiently purified. By integrating distinct photo-responsive chemical linkages, we achieved selective activation of crRNA activity upon irradiation with specific wavelengths, enabling orthogonal regulation of multiple genetic targets simultaneously. This method demonstrated robust OFF-ON switching capabilities in vitro, characterized by minimal leakage and rapid activation. Importantly, the approach also proved highly effective for temporally controlled gene editing in mammalian cells in vivo, achieving considerable editing efficiency following brief photoactivation. Due to its target sequence-independent, single-site modification design, this strategy may serve as a universal solution for diverse CRISPR/Cas systems, eliminating cumbersome optimization processes. Future advancements incorporating long-wavelength responsive and reversible linkers promise further enhancement of tissue penetration and control, significantly broadening the applicability and impact of this approach in biological research and therapeutic interventions.}, archive = {J_ANGEW}, author = {Wen-Da Chen and Li Liu and Liang Cheng}, doi = {10.1002/anie.202506527}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506527}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functionally tunable star-shaped multivalent crRNAs for photocontrol CRISPR/Cas editing}, volume = {64}, year = {2025}, }
• (2025). Photothermal catalytic synthesis of sulfonic acid functionalized covalent organic framework achieved by COF-to-COF transformation for photocatalysis. ANGEW, 64(25), e202506509. (www)

  @article{ , abstract = {Although photothermal catalysis is a clean, efficient, and green approach to access organic products, its application in the synthesis and transformation of covalent organic frameworks (COFs) remains unprecedented. Herein, we report the photothermal catalytic synthesis of C─C bond linked COF under visible light, which can be a reusable photocatalyst to highly promote oxidation of benzyl amines. Furthermore, we have developed a new postsynthetic modification strategy to construct COFs by photoinduced thermally-driven hydroamination via crystal-to-crystal transformation. The obtained COF containing sulfonic acid group showed an excellent catalytic performance in promoting aerobic oxidation of alkyl arenes under mild reaction conditions. These results not only enrich the COF synthetic methodology but also open a new route to access COFs in a green and sustainable way.}, archive = {J_ANGEW}, author = {Hui-Chao Ma and Meng-Yao Gu and Ming-Zhe Li and Chang-You Gu and Dong-Fang Zhu and Gong-Jun Chen and Yu-Bin Dong}, doi = {10.1002/anie.202506509}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506509}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photothermal catalytic synthesis of sulfonic acid functionalized covalent organic framework achieved by COF-to-COF transformation for photocatalysis}, volume = {64}, year = {2025}, }
• (2025). A hypoxia-triggered bioreduction of hydrophilic type i photosensitizer for switchable in vivo photoacoustic imaging and high-specificity cancer phototherapy. ANGEW, 64(25), e202506412. (www)

  @article{ , abstract = {Considering that hypoxia is strongly connected with tumor proliferation, metastasis, invasion, and drug resistance, it is of significant implication for alleviating the effects of hypoxia in tumor treatment. The negligible oxygen-dependent nature of type I photosensitizers (PSs) has made them appropriate candidates for the treatment of hypoxic tumors. However, the lack of effective molecular design approaches, the phototoxicity of PSs to normal tissue before and after treatment, and the drawbacks of poor hydrophilicity severely hinder the development of PSs in hypoxic tumor therapy. Thus, developing a hydrophilic PS with good hypoxia resistance and minimal side effects is an urgent but challenging problem. Herein, we present a nanotheranostic ( NanoPcN8O ) based on the self-assembly of a hydrophilic phthalocyanine derivative ( PcN8O ), a hypoxia-responsive bioreductive phototherapeutic agent suitable for activatable photoacoustic (PA) imaging and tumor therapy. Hypoxic regions in various tumors exhibit strong reductive capability, and only in such conditions did NanoPcN8O feature multiple N -oxide groups that could be bioreduced to yield the product NanoPcN8 with abundant electron-rich tertiary amine groups, which switches on the type I photodynamic and photothermal effects, facilitating the generation of type I reactive oxygen species (ROS) and heat. Better still, NanoPcN8O achieved hypoxia-induced selective PA imaging in a preclinical model. Based on these merits, the hypoxia-induced switchable type I photodynamic therapy (PDT) and photothermal therapy (PTT) strategies demonstrated remarkable phototherapeutic efficiency with high biosafety. This delicate design is anticipated to offer a novel and safe strategy to overcome hypoxia resistance in phototherapeutics.}, archive = {J_ANGEW}, author = {Yuan-Yuan Zhao and Yihui Xu and Xiaojun Zhang and Zixuan Chen and Heejeong Kim and Xingshu Li and Juyoung Yoon}, doi = {10.1002/anie.202506412}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506412}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A hypoxia-triggered bioreduction of hydrophilic type i photosensitizer for switchable in vivo photoacoustic imaging and high-specificity cancer phototherapy}, volume = {64}, year = {2025}, }
• (2025). Electrochemical synthesis of hydrogen peroxide enabled by tri-coordinated cobalt sites in silicate-1 zeolite. ANGEW, 64(25), e202506390. (www)

  @article{ , abstract = {Electrochemical synthesis of hydrogen peroxide (H 2 O 2 ) via metal-catalyzed two-electron oxygen reduction reaction (2e − ORR) emerges as a sustainable alternative to the traditional anthraquinone method. However, metal catalysts are commonly supported by graphitic carbon that is susceptible to being oxidized by reactive oxygen species generated in ORR and have limited oxygen capacities. Here, we report a silica-based electrocatalyst embedding cobalt (Co) sites into silicate-1 (S-1) zeolite, which exhibited exceptional 2e − ORR performance. The aligned microporosity of S-1 zeolite highly isolated Co sites to derive a specific tri-coordination unit of Co(OSi) 3 moiety. The nanochannels of S-1 zeolite further provide robust and substantial reaction spaces, where the Co(OSi) 3 moiety facilitates O 2 chemisorption and holds moderate bonding with *OOH intermediates to reduce the barrier of H 2 O 2 formation. It achieved high Faradaic efficiency over 96% and a steady yield of 11.56 mol g cat −1 h −1 in a gas diffusion electrode setup. This work provides a novel insight into 2e − ORR on Co sites and highlights the potential of zeolite-based materials for electrochemical applications.}, archive = {J_ANGEW}, author = {Guanghua Yu and Yingying Jin and Ye Zhou and Jing Xia and Xiangmin Meng and Guoliang Dai and Jiong Wang}, doi = {10.1002/anie.202506390}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical synthesis of hydrogen peroxide enabled by tri-coordinated cobalt sites in silicate-1 zeolite}, volume = {64}, year = {2025}, }
• (2025). Stepwise crystallization synthetic strategy for monodisperse InSb colloidal quantum dots with mid-infrared absorption. ANGEW, 64(25), e202506387. (www)

  @article{ , abstract = {Colloidal InSb quantum dots (QDs) are promising mid-infrared (MIR) photodetection materials due to their suitable bandgap, unparalleled room temperature electronic properties, environmental-friendly elemental composition, and facile solution processability. However, current InSb QDs suffer from limited spectral absorption within 2 µm, polydisperse QDs populations, and complex size-selective precipitation for further use, due to the lack of applicable growth theory and synthetic method. Here, we present a novel synthetic strategy for InSb QDs, which is featured by the initial formation of an amorphous intermediate and a subsequent stepwise crystallization process. This strategy enables the achievement of monodisperse InSb QDs with unprecedented 5.8–22.2 nm size range, and a remarkably low size distribution deviation of 5.8% without the need of any size-selective precipitation. For the first time, we realize the synthesis of InSb QDs with absorption wavelength exceeding 3000 nm, the record among the environmental-friendly QDs. The results presented here will pave the way toward environmental-friendly QDs as outstanding infrared optical and optoelectronic materials and push the frontier of solution-processed QDs into the mid-infrared regime applications.}, archive = {J_ANGEW}, author = {Qingyu Wang and Cong Sun and Zifeng Liu and Bin Zeng and Yifan Chen and Zhe Liu and Huangpeng You and Xingyu Hu and Peixian Li and Junjie Zhang and Xiaoqi Hou and Ning Dai and Yang Li}, doi = {10.1002/anie.202506387}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506387}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stepwise crystallization synthetic strategy for monodisperse InSb colloidal quantum dots with mid-infrared absorption}, volume = {64}, year = {2025}, }
• (2025). Photoelectrocatalytic degradation mechanism of fluorinated pollutants using a bilayer WO3 photoanode: Synergistic role of holes and hydroxyl radicals. ANGEW, 64(25), e202506322. (www)

  @article{ , abstract = {Fluorinated organic pollutants pose significant environmental and health risks due to the high stability of C─F bonds, necessitating effective strategies for their degradation. Herein, we present a bilayer WO 3 photoelectrode (double-WO 3 ) incorporating an electron transport layer (ETL) and a hexagonal-monoclinic heterophase junction for PEC degradation of fluorinated pollutants. The double-WO₃ catalyst achieves a high photocurrent density (4.3 mA cm −2 at 1.2 V RHE ) and nearly complete degradation (99.9%) of bisphenol AF (BPAF), 4-fluorophenol (4-FP), and pentafluorophenol (PFP), with 99.9% mineralization of PFP. Experimental and transient photocurrent (TPC) analyses confirm that the ETL-heterophase junction structure enhances electron extraction and surface reaction kinetics while minimizing electron-hole recombination. In this process, photogenerated h⁺ excites fluorinated pollutants, enhancing C─F bond susceptibility to ∙OH attack, which facilitates bond cleavage and subsequent oxidation into CO 2 , H 2 O, and F − . This study offers a promising strategy for designing advanced PEC systems and effectively remediating persistent fluorinated contaminants.}, archive = {J_ANGEW}, author = {Qiuling Ma and Dongfeng Li and Fujun Ren and Wensheng Gao and Rui Song and Zelong Li and Can Li}, doi = {10.1002/anie.202506322}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506322}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoelectrocatalytic degradation mechanism of fluorinated pollutants using a bilayer WO3 photoanode: Synergistic role of holes and hydroxyl radicals}, volume = {64}, year = {2025}, }
• (2025). Deciphering complex electrochemical reaction dynamics and interactions of single nanoentities via evanescent scattering microscopy. ANGEW, 64(25), e202506226. (www)

  @article{ , abstract = {Electrochemical reactions at the nanoscale are governed by intricate surface interactions, yet existing imaging techniques often lack the surface sensitivity and throughput needed to resolve these dynamics clearly. Here, we introduce electrochemical evanescent scattering microscopy (EC-ESM), a high-throughput, surface-sensitive imaging technique that enables real-time tracking of single-nanoentity electrochemistry with high resolution. Using EC-ESM, we monitored the motion and dissolution dynamics of silver nanoparticles and identified a clear relationship between nanoparticle velocity and electron transfer rates. The high throughput of EC-ESM not only ensures statistical reliability but also allows the detection of rare electron transfer events in molecularly modified AgNPs. Additionally, EC-ESM's high resolution enabled direct imaging of both single and interacting silver nanowires, revealing diverse dissolution behaviors that provide insights into structural and surface properties. We envision EC-ESM as a powerful platform for advancing nanoscale electrochemical research and interfacial charge transfer studies.}, archive = {J_ANGEW}, author = {Jiaying Li and Peng Lin and Liwei Wu and Yuxi Yue and Guangzhong Ma}, doi = {10.1002/anie.202506226}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506226}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering complex electrochemical reaction dynamics and interactions of single nanoentities via evanescent scattering microscopy}, volume = {64}, year = {2025}, }
• (2025). Suppressing dendrite growth by dolosse-structured ZIF-67 polycrystalline membranes through eliminating interfacial electrolyte turbulence on zinc anode. ANGEW, 64(25), e202506222. (www)

  @article{ , abstract = {Aqueous Zn-ion batteries (ZIBs) are considered a promising candidate for next-generation energy storage devices, but the Zn dendrite problem limits their practical application potential. Although existing solutions, such as electrolyte additives and electrode coatings, can effectively address this issue, but almost all these solutions are based on a static electrolyte model and overlook the relationship between electrolyte flow and dendrite growth. Herein, inspired by the principle of dolosse to reduce the impact of waves on coastlines, we utilized the epitaxial growth characteristics of metal-organic frameworks (MOFs) to construct a ZIF-67 polycrystalline membrane with macro-microporous on Zn foil (D-67M@Zn). The dolosse-like structure of the membrane effectively eliminates turbulence at the electrode–electrolyte interface, enabling Zn 2+ to deposit in a stable electrolyte environment, reducing the secondary nucleation rate of Zn, and inhibiting dendrite growth. The macro-microporous skeleton also helps regulate the morphology of Zn deposition, as confirmed by fluid dynamics analysis and AC-STEM. Benefiting from the unique properties of D-67M, both symmetric cells and full cells based on the D-67M@Zn anode exhibit impressive cycling stability.}, archive = {J_ANGEW}, author = {Haiyang Wu and Wenyu Ma and Langyuan Wu and Wendi Dong and Yang Li and Zengjie Fan and Xuening Zhao and Peng Huang and Xiaogang Zhang}, doi = {10.1002/anie.202506222}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506222}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Suppressing dendrite growth by dolosse-structured ZIF-67 polycrystalline membranes through eliminating interfacial electrolyte turbulence on zinc anode}, volume = {64}, year = {2025}, }
• (2025). Extending frontier molecular orbitals delocalization via donor fusion: Construct long-wavelength twisted multiple resonance emitters with efficient narrowband emission. ANGEW, 64(25), e202506201. (www)

  @article{ , abstract = {Multiple resonance thermally activated delayed fluorescence (MR-TADF) emitters are promising candidates for ultra-high-definition organic light-emitting diodes (OLEDs) displays. Here, we propose a general strategy for post-functionalizing MR core, introducing donors on the lowest unoccupied molecular orbital (LUMO) position via Suzuki coupling and then fusing the donors to the highest occupied molecular orbital (HOMO) position via Scholl cyclization, which can extend frontier molecular orbitals delocalization to construct long-wavelength narrowband emitters. Two proof-of-concept molecules, BN-PhAzCz and BN-tCzAzPh, are constructed, achieving large spectral red-shifts while maintaining narrowband emission. The distorted configuration resulting from the hetero[6]helicene structure introduces twisted π–π* transition, which effectively enhances spinorbit coupling, ultimately enabling molecule BN-PhAzCz to achieve a fast reverse intersystem crossing rate (kRISC = 6.4 × 104 s −1 ). BN-PhAzCz-based single-host OLED exhibits green emission at 528 nm with Commission Internationale de L'Eclairage (CIE) coordinates of (0.26, 0.69) and maximum external quantum efficiency (EQE) of 38.2% with efficiency roll-off of 28.0% at 1000 cd m −2 under 5 wt% doping concentration. Even at 20 wt% doping concentration, the maximum EQE remains at 29.6% with little change in the spectral profile.}, archive = {J_ANGEW}, author = {Yupei Qu and Yincai Xu and Tingting Huang and Xiaoxian Song and Kaiqi Ye and Yue Wang}, doi = {10.1002/anie.202506201}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506201}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Extending frontier molecular orbitals delocalization via donor fusion: Construct long-wavelength twisted multiple resonance emitters with efficient narrowband emission}, volume = {64}, year = {2025}, }
• (2025). Non-precious metal catalysts with gradient oxidative dual sites boost bimolecular activation for catalytic oxidation reactions. ANGEW, 64(25), e202506018. (www)

  @article{ , abstract = {Catalytic oxidation emerges as a highly promising and cost-effective approach for eliminating gaseous pollutants, greenhouse gases, and volatile organic compounds (VOCs) from industrial exhaust streams. However, achieving the simultaneous activation of O 2 and substrate molecules at low temperatures using non-precious metal catalysts remains a significant challenge. In this study, we introduce gradient oxidative Cu─O─Ti/Cu─O─Cu dual sites that enhance bimolecular activation for catalytic oxidation reactions. The catalyst, Ti-doped CuO, is synthesized on a TiO 2 support through the immobilization of Cu 2⁺ on NO 3 ⁻-grafted TiO 2 , followed by thermal treatment. The resulting gradient oxidative Cu─O─Ti/Cu─O─Cu sites exhibit exceptional catalytic oxidation activity for NH 3 and various VOCs at low temperatures, matching the performance of precious metal-based catalysts. Notably, during NH₃ oxidation, Cu─O─Ti sites enhance the activation of both O₂ and NH₃. HNO intermediates formed on Cu─O─Ti sites react with NH intermediates on neighboring Cu─O─Cu sites—producing N₂ and H₂O via an imide mechanism—which effectively lowers the reaction barrier for catalytic NH₃ oxidation. As such, dual sites in non-precious metal catalysts show promising results for advancing future catalytic oxidation technologies.}, archive = {J_ANGEW}, author = {Yufei Wang and Tianwei Lan and Lupeng Han and Evangelina Pensa and Yongjie Shen and Xingchi Li and Zixiang Xu and Xin Chen and Mengxue Wang and Xiaoya Xue and Yanqing Li and Ming Xie and Emiliano Cortés and Dengsong Zhang}, doi = {10.1002/anie.202506018}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202506018}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-precious metal catalysts with gradient oxidative dual sites boost bimolecular activation for catalytic oxidation reactions}, volume = {64}, year = {2025}, }
• (2025). Catch, cut, or block? versatile 4-N-derivatized sialyl glycosides for influenza virus neuraminidase detection and purification. ANGEW, 64(25), e202505903. (www)

  @article{ , abstract = {Seasonal influenza continues to threaten human lives and pose a significant burden to healthcare systems and the economy, emphasizing the need for developing better influenza vaccines, diagnostics, and antiviral therapeutics. To address these challenges, we generated a library of structurally diverse sialyl glycosides containing 4- N -derivatized sialic acids by a highly efficient one-pot two-enzyme chemoenzymatic sialylation strategy. Sialosides containing 4-azido-substituted sialic acid were selectively cleaved by sialidases from influenza viruses, whereas sialosides containing 4-acetamido-modified sialic acid were resistant to sialidase cleavage. Interestingly, sialosides containing 4-amino- or 4-guanidino-substituted sialic acid were effective inhibitors moderately or highly resistant to cleavage by influenza sialidases (also called neuraminidases). The sialosides containing the 4-guanidino-substituted sialic acid represent a new class of sialidase substrate analog-based inhibitors. We took advantage of this unique property to create a ligand-based approach for efficiently isolating influenza virions from egg allantoic fluid with high purity. Together, these compounds are versatile probes and ligands for developing new approaches to detect, profile, isolate, and characterize influenza viruses via neuraminidases on their surface.}, archive = {J_ANGEW}, author = {Yue Yuan and Hai Yu and Anand Kumar Agrahari and Jin Gao and Hyeog Kang and Robert Daniels and Xi Chen}, doi = {10.1002/anie.202505903}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505903}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catch, cut, or block? versatile 4-N-derivatized sialyl glycosides for influenza virus neuraminidase detection and purification}, volume = {64}, year = {2025}, }
• (2025). Water-in-acid strategy for corrosion-free proton storage: Phosphoric acid electrolyte engineering toward sustainable aqueous batteries. ANGEW, 64(25), e202505769. (www)

  @article{ , abstract = {Aqueous proton batteries, leveraging the intrinsic advantages of protons such as minimal hydrated radius, natural abundance, and rapid transport kinetics, have emerged as promising candidates for next-generation energy storage. However, conventional strong acid electrolytes like H 2 SO 4 suffer from critical limitations including electrode dissolution and incompatibility with battery components. To circumvent these challenges, weak acids (e.g., HCOOH and H 3 PO 4 ) have been strategically selected as alternative electrolytes due to their non-corrosive characteristics. Particularly, the implementation of high-concentration “water-in-acid” (WIA) effectively suppresses undesirable interactions between electrode materials and free water molecules. Through electrolyte engineering, we developed a 9.5 M H 3 PO 4 WIA system that synergizes with a molybdenum trioxide electrode, achieving remarkable electrochemical performance: a high reversible capacity of 229.8 mAh g −1 at 3 A g −1 and exceptional cycling stability with 83.86% capacity retention after 1000 cycles at 5 A g −1 , surpassing conventional H₂SO₄-based systems by both capacity and cyclability. This innovative approach establishes a new paradigm for developing high-performance aqueous energy storage systems through acid-dominated electrolyte design.}, archive = {J_ANGEW}, author = {Baiming Su and Junqiang Deng and Zhouxiang Wu and Xinran Li and Jing Li and Haoxiang Yu and Peng Li and Hui Li and Lei Yan and Liyuan Zhang and Ting-Feng Yi and Tianyi Ma and Jie Shu}, doi = {10.1002/anie.202505769}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505769}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Water-in-acid strategy for corrosion-free proton storage: Phosphoric acid electrolyte engineering toward sustainable aqueous batteries}, volume = {64}, year = {2025}, }
• (2025). Achieving high fill factor via increasing interfacial disorder to inhibit bimolecular recombination for efficient organic solar cells. ANGEW, 64(25), e202505722. (www)

  @article{ , abstract = {The inferior fill factor (FF) is one of main reasons impeding further improvement of power conversion efficiencies (PCEs) in organic solar cells (OSCs). But no theoretical framework for high FFs has been established yet. Herein, an efficient strategy is developed to enhance FFs via introducing a small molecule, CNDT, into active layer. CNDT increases the electron donor/acceptor interface disorder, raises the energy barrier for charge back transfer, and thus reduces bimolecular recombination rate constant ( k rec ). We show that CNDTs distribute across electron donor/acceptor interfaces of D18:Y6+, disturbe the molecular stacking of Y6, lead to a more disordered interfaces, while maintaining higher crystal quality compared to D18:Y6. This disorder, along with a higher energy of charge transfer states magnifies the energy barrier for charge recombination, decreases charge recombination rate/ratio, reduces k rec , and inhibits bimolecular recombination in devices. Therefore, FFs of OSCs are improved from 75.78% (D18:Y6) to 81.13% (D18:Y6+), yielding a higher PCE of 19.45%. Moreover, D18:L8-BO+ based OSCs feature FFs over 83%, a record for OSCs so far, with PCEs reaching 19.80%. This work demonstrates that increasing interface disorder, without sacrificing crystal quality, enhances energy barriers of charge recombination and inhibits bimolecular recombination to efficiently improve FFs for higher PCEs.}, archive = {J_ANGEW}, author = {Dan He and Linwei Xie and Yahui Bai and Huotian Zhang and Liping Liu and Jingyao Kong and Yongqiang Chai and Xiaojun Li and Mengni Wang and Yajie Zhang and Jianqi Zhang and Yongfang Li and Feng Gao and Dirk M. Guldi and Fuwen Zhao}, doi = {10.1002/anie.202505722}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505722}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving high fill factor via increasing interfacial disorder to inhibit bimolecular recombination for efficient organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Accelerated oxide-zeolite catalyst design for syngas conversion by reaction phase diagram analysis and machine learning. ANGEW, 64(25), e202505589. (www)

  @article{ , abstract = {Oxide-zeolite (OXZEO) catalyst design concept provides an alternative approach for the direct syngas-to-olefins (STO) with superior selectivity. Enhancing the activity of oxide components remains a critical and long-pursued target in this field. However, rational design strategies for optimizing oxides and improving the catalyst performance in such complex reaction networks are still lacking. We employed energetic descriptors such as the adsorption energies of CO* and O* ( G ad CO* and G ad O*) through reaction phase diagram (RPD) analysis to predict the catalyst performance. The prediction was initially validated by the catalytic activity trends measured by experiments. Machine learning (ML) was further utilized to accelerate the screening of new catalysts. Ultimately, Bi-doped and Sb-doped ZnCrO x were theoretically predicted as optimized oxide candidates for the OXZEO reaction, which was experimentally verified to be more active than the currently best ZnCrO x counterpart. This work demonstrated enhanced OXZEO catalysts for STO as well as a research paradigm integrating theory and experiment to optimize bifunctional catalysts for complex reaction networks.}, archive = {J_ANGEW}, author = {Yihan Ye and Bing Bai and Yilun Ding and Xinzhe Li and Feng Jiao and Jianping Xiao and Xiulian Pan}, doi = {10.1002/anie.202505589}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerated oxide-zeolite catalyst design for syngas conversion by reaction phase diagram analysis and machine learning}, volume = {64}, year = {2025}, }
• (2025). Proteome-wide data guides the discovery of lysine-targeting covalent inhibitors using DNA-encoded chemical libraries. ANGEW, 64(25), e202505581. (www)

  @article{ , abstract = {Broadening the application of covalent inhibitors requires the exploration of nucleophilic residues beyond cysteine. The covalent DNA-encoded chemical library (CoDEL) represents an advanced technology for covalent drug discovery. However, its application in lysine-targeting inhibitors remains uncharted territory. Here, we report the utilization of CoDEL selection guided by proteome-wide data to identify lysine-targeting covalent inhibitors. A comprehensive assessment of activity-based protein profiling (ABPP) data on lysine distribution and ligandability reveals potential targets for selective covalent inhibition, including phosphoglycerate mutase 1 (PGAM1), bromodomain (BRD) family proteins, and ubiquitin-conjugating enzyme E2 N (UBE2N). The 10.7-million-member CoDELs, featuring diverse lysine-reactive warheads, enable the discovery of a series of covalent inhibitors, covering photo-covalent, reversible covalent, and irreversible covalent reaction mechanisms. In-depth characterization of binding sites and modes of action provides structural and functional insights. Notably, irreversible covalent inhibitors unveil a novel mechanism for regulating UBE2N-mediated ubiquitination by modulating the conformation of the protein complex. Our work adopts the ABPP-CoDEL strategy, offering an efficient and versatile selection method for the development of covalent inhibitors targeting functional lysines.}, archive = {J_ANGEW}, author = {Xinyuan Wu and Shunyao Li and Ting Liang and Qing Yu and Yiwei Zhang and Jiaxiang Liu and Kaige Li and Zijian Liu and Mengqing Cui and Yongchao Zhao and Xin Han and Rui Jin and Minjia Tan and Xiao-Hua Chen and Yujun Zhao and Mingyue Zheng and Yi Sun and Lu Zhou and Xiaojie Lu}, doi = {10.1002/anie.202505581}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505581}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proteome-wide data guides the discovery of lysine-targeting covalent inhibitors using DNA-encoded chemical libraries}, volume = {64}, year = {2025}, }
• (2025). Ternary metalation in a copper-covalent organic framework for tandem photocatalytic CO2 reduction with high selectivity. ANGEW, 64(25), e202505546. (www)

  @article{ , abstract = {Developing multifunctional photocatalysts with efficient synergistic effects for selective photocatalytic CO 2 reduction is sought-after yet challenging. Herein, a tandem photocatalytic strategy has been developed through sequential post-synthetic metalation (SPSM) of variable Ru/Co-sites into a trinuclear Cu-based COF, Cu 3 -BPY-COF, to construct a series of tri-metallized covalent-organic frameworks (COFs), Cu 3 -BPY-COF(Ru/Co)-X (X = 1, 2, or 3, corresponding to the Ru:Co molar ratios of 1/39.6, 1/19.6, or 1/12.7, respectively), for photocatalytic CO 2 methanation in high selectivity. The introduction of a small fraction of Ru-sites confers the framework with enhanced visible-light response, while the Co-sites immobilized in the bipyridine units significantly boost the generation of CO to enrich its concentration around the active trinuclear Cu-sites, which enables dramatically improved photocatalytic CO 2 reduction activity toward CH 4 . Significantly, the optimized Cu 3 -BPY-COF(Ru/Co)-2 showcases exceptional photocatalytic activity with a CH 4 evolution rate of 31.5 µmol g −1 h −1 and selectivity of 95%, 15.0 times higher than that of Cu 3 -BPY-COF(Ru) merely introducing Ru-photosensitizer. The underlying photocatalytic mechanism has been studied to unveil how the ternary Ru/Co/Cu-sites collaborate to result in highly efficient and selective CO 2 -to-CH 4 reduction, shedding light on the design of highly selective CO 2 methanation photocatalysts by leveraging the synergistic effect of multiple active centers within heterometallic covalent-organic frameworks (HM-COFs).}, archive = {J_ANGEW}, author = {Wei Geng and Yang-Yang Xiong and Cheng-Xia Chen and Shunlian Ning and Zhuo Xiong and Songlin Deng and Yuxuan Tan and Xianmeng Song and Mei Pan and Marcel Mayor and Cheng-Yong Su}, doi = {10.1002/anie.202505546}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505546}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ternary metalation in a copper-covalent organic framework for tandem photocatalytic CO2 reduction with high selectivity}, volume = {64}, year = {2025}, }
• (2025). Synergistic conversion of hydrogen peroxide and benzaldehyde in air by silver single-atom modified thiophene-functionalized g-C3N4. ANGEW, 64(25), e202505532. (www)

  @article{ , abstract = {This study reports the synthesis of silver single-atom-loaded thiophene-conjugated carbon nitride (Ag@T─C 3 N 4 ), a material with high carrier concentration and efficient carrier separation. Under visible light, Ag@T─C 3 N 4 catalyzes hydrogen peroxide (H 2 O 2 ) production and benzyl alcohol oxidation to benzaldehyde, achieving production rates of 4729.82 µmol·g −1 ·h −1 for H 2 O 2 and 19.71 mmol·g −1 ·h −1 for benzaldehyde. The synergy between thiophene conjugation and silver atoms extends visible light absorption and accelerates the 2-electron oxygen reduction reaction (ORR), enhancing H 2 O 2 yield. Photogenerated holes oxidize benzyl alcohol to benzaldehyde, while the biphasic benzaldehyde-water system enables spontaneous product separation. In situ Raman spectroscopy, rotating disk electrode testing, EPR, GC-MS, and DFT calculations highlight the critical role of thiophene-silver synergy in optimizing reaction pathways, enhancing catalyst-intermediate interactions, and reducing Gibbs free energy, improving H 2 O 2 and benzaldehyde synthesis. This study provides new insights for designing carbon nitride-based photocatalysts and offers a strategy for co-producing value-added chemicals.}, archive = {J_ANGEW}, author = {Xiaoyu Zhou and Kuanhong Cao and Shouqiang Huang and Haonan Wu and Zhen Cao and Hang Liu and Peng Chen and Dawei Su and Guoxiu Wang and Tianyi Wang and Chengyin Wang and Huan Pang}, doi = {10.1002/anie.202505532}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505532}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic conversion of hydrogen peroxide and benzaldehyde in air by silver single-atom modified thiophene-functionalized g-C3N4}, volume = {64}, year = {2025}, }
• (2025). 3-oxabicyclo[3.1.1]heptane as an isostere of meta-benzene. ANGEW, 64(25), e202505519. (www)

  @article{ , abstract = {3-Oxabicyclo[3.1.1]heptanes were designed as saturated isosteres of meta -benzene. Crystallographic analysis revealed that these structures and meta -benzene have identical geometric properties. Replacement of the central benzene ring in the anticancer drug Sonidegib with 3-oxabicyclo[3.1.1]heptane provided a patent-free analogue with a nanomolar potency, reduced lipophilicity, and improved water solubility (>500%).}, archive = {J_ANGEW}, author = {Dmitry Dibchak and Pavel K. Mykhailiuk}, doi = {10.1002/anie.202505519}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505519}, shortjournal = {Angew. Chem. Int. Edit.}, title = {3-oxabicyclo[3.1.1]heptane as an isostere of meta-benzene}, volume = {64}, year = {2025}, }
• (2025). Wearing gigantic silver armor on transition-metal-containing polyoxometalates: Formation of supertetrahedral intercluster compounds. ANGEW, 64(25), e202505511. (www)

  @article{ , abstract = {Compared to versatile polyoxometalate (POM)-templated Ag clusters, the construction of closed Ag clusters using transition-metal-containing polyoxometalates (TMCPOMs) as anionic templates has, to our knowledge, never been reported. In this work, we have synthesized three TMCPOM-templated gigantic closed Ag clusters, [{(Co 0.58 W 0.42 ) 3 (OH) 3 (Ag 0.5 O 3 )(SiW 9 O 34 )} 4 @Ag 114 Br 4 ( t BuC≡C) 72 ]·[SiW 12 O 40 ] 2 ·10CH 3 CN ( 1 ), [{(Cu 0.58 W 0.42 ) 3 (OH) 3 (Ag 0.5 O 3 )(SiW 9 O 34 )} 4 @Ag 114 Br 4 ( t BuC≡C) 72 ]·[SiW 12 O 40 ] 2 ( 2 ), and [{(Co 0.58 W 0.42 ) 3 (OH) 3 (Ag 0.5 O 3 )(GeW 9 O 34 )} 4 @Ag 114 Br 4 ( t BuC≡C) 72 ]·[GeW 12 O 40 ] 2 ( 3 ), using a universal one-pot solvothermal synthetic approach. Single-crystal X-ray diffraction analyses demonstrate that the high-nuclearity transition metal-containing (M = Co/Cu) POMs with idealized T d symmetry are closely covered by gigantic Ag armors, representing the largest TMCPOM-templated closed Ag clusters to date. Moreover, compounds 1 − 3 can form interesting supertetrahedral intercluster packing structures through Columbic and hydrogen bonding interactions between the cationic TMCPOM-templated gigantic {Ag 114 } clusters and the counter [XW 12 O 40 ] 4− (X = Si/Ge) anions. Upon light irradiation, all three compounds exhibited decent photocatalytic CO 2 reduction activity, which is dependent on their different electronic structures.}, archive = {J_ANGEW}, author = {Yeqin Feng and Mengyun Zhao and Jiaxin Yang and Zhimin Wang and Penghao Bai and Yongkang Liu and Hongjin Lv and Guo-Yu Yang}, doi = {10.1002/anie.202505511}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505511}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Wearing gigantic silver armor on transition-metal-containing polyoxometalates: Formation of supertetrahedral intercluster compounds}, volume = {64}, year = {2025}, }
• (2025). Constructing large-area oriented covalent organic framework based PN heterostructure films to enhance artificial photosynthesis of H2O2. ANGEW, 64(25), e202505491. (www)

  @article{ , abstract = {Two-dimensional conjugated covalent organic framework (COF) films exhibit enormous application potential in the photosynthesis of hydrogen peroxide (H 2 O 2 ), however, they suffer from various photogenerated electron-hole recombination. Herein, we first report a new strategy of in situ constructing oriented COF-based PN heterostructure film through single-layer MoS 2 induced growth, significantly enhancing the photogenerated carrier separation efficiency, which promotes the photocatalytic H 2 O 2 synthesis. Experimental results reveal that the as-made oriented TAPB-DMTA COF/MoS 2 (TAPB: 1,3,5-tris(4-aminophenyl) benzene, DMTA: 2,5-Dimethoxyterephthalaldehyde) film exhibits a high photocatalytic H 2 O 2 yield of 8154 µmol g −1 h −1 , which is ∼2.5 times and ∼4 times higher than that of non-oriented TAPB-DMTA COF films and powder. The mechanism reveals that the oriented structure of the TAPB-DMTA COF can significantly promote the generation and the transmission of photogenerated electron-hole pairs along the skeleton and layer-by-layer stacking direction, thus enhancing the photocatalytic H 2 O 2 performance. The new strategy of in situ constructing oriented COFs-based PN heterostructure film for enhancing the photosynthesis of H 2 O 2 will open the door to rational design of molecular films towards high photogenerated carrier separation efficiency.}, archive = {J_ANGEW}, author = {Minghui Liu and Yachao Xu and Youxing Liu and Shengcong Shang and Wenqiang Gao and Xinyu Wang and Jiaxin Hong and Helin Xu and Chunyu Hua and Zewen You and Zhixia Zhou and Shaojun Guo and Yunqi Liu and Jianyi Chen}, doi = {10.1002/anie.202505491}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505491}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing large-area oriented covalent organic framework based PN heterostructure films to enhance artificial photosynthesis of H2O2}, volume = {64}, year = {2025}, }
• (2025). Boosting hydrogenation of CO2 using cationic cu atomically dispersed on 2D γ-Al2O3 nanosheets. ANGEW, 64(25), e202505444. (www)

  @article{ , abstract = {The continuous development of novel catalytic approaches is crucial for advancing efficient CO 2 hydrogenation processes. Drawing inspiration from single-atom catalysis and 2D materials, we designed a new 2D single-atom catalyst with excellent thermal stability by thermally treating Cu-adsorbed γ-AlOOH nanosheets, which yielded a Cu/γ-Al 2 O 3 catalyst with high activity in the hydrogenation of CO 2 -yielding methanol (CH 3 OH), dimethyl ether (DME), and CO as products. The active Cu sites are monodispersed and highly stable due to their cationic oxidation state and their substitution for pentacoordinated aluminum (Al P ) sites on particle surfaces. This study demonstrates an efficient approach for achieving a high CO 2 hydrogenation rate (30.45 mol mol −1 h −1 ) using a catalyst system that lacks metallic Cu centers, traditionally considered essential for H₂ dissociation, and employs what was previously thought to be an inert metal oxide (γ-Al 2 O 3 ) for CO and CH 3 OH production. Ongoing mechanistic studies aim to elucidate the synergy between cationic Cu single atoms and γ-Al 2 O 3 , a Lewis acid support, in facilitating hydrogen (H 2 ) activation and methanol formation.}, archive = {J_ANGEW}, author = {Ping Chen and Yifeng Zhu and Hailin Zhang and Micah P. Prange and Duo Song and Janos Szanyi and Yining Wang and Ying Chen and Xiang Wang and Oliver Y. Gutiérrez and Zihua Zhu and Zheming Wang and Carolyn I. Pearce and Ping Li and Kevin M. Rosso and Honghong Shi and Xin Zhang}, doi = {10.1002/anie.202505444}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting hydrogenation of CO2 using cationic cu atomically dispersed on 2D γ-Al2O3 nanosheets}, volume = {64}, year = {2025}, }
• (2025). Reverse regioselective dicarbofunctionalization via anti-michael-type addition. ANGEW, 64(25), e202505391. (www)

  @article{ , abstract = {Vicinal dicarbofunctionalization of α,β-unsaturated carbonyl compounds is a classical yet versatile method for constructing complex molecular architectures in a single step. However, the regioselectivity is typically governed by the electronic properties of the alkene moiety, leading to the introduction of a nucleophile at the β-position and an electrophile at the α-position. Herein, we report a palladium-catalyzed dicarbofunctionalization of acrylamides via anti -Michael-type addition, achieving reverse regioselectivity relative to traditional approaches. This strategy enables the efficient incorporation of various (hetero)arene nucleophiles at the α-position and carbon electrophiles, including iodoarenes, vinyl iodides, and iodomethane, at the β-position to furnish dicarbofunctionalized amides in good yields. Mechanistic investigations suggest that the reaction proceeds through an alkylpalladium intermediate formed via the α-addition of a nucleophile.}, archive = {J_ANGEW}, author = {Hirotsugu Suzuki and Ryota Moro and Takanori Matsuda}, doi = {10.1002/anie.202505391}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reverse regioselective dicarbofunctionalization via anti-michael-type addition}, volume = {64}, year = {2025}, }
• (2025). Flow battery with remarkably stable performance at high current density: Development of a nonfluorinated separator with concurrent rejection and conductivity. ANGEW, 64(25), e202505383. (www)

  @article{ , abstract = {Redox flow batteries show promise for large-scale grid stabilisation. Of these, organic redox flow batteries (ORFBs) harbour the potential for sustainable and economic operation due to the materials deployed. Their long-term operation requires exquisite transport control of species across the cell, with movement of cations key for high current density, and anionic rejection needed for cycling stability. Nafion, although promising as a commercial separator, faces cost and sustainability limitations due to its fluorinated nature and per- and polyfluroralkyl substances (PFAS) generation. Here, we report the tailored combination of a hydrophilic mixed-matrix membrane, SPEEK-SX, with sulphonated polydichloroxylene (S p -DCX) as the additive and sulphonated poly(ether ether ketone) (SPEEK) as the matrix. Compared to Nafion-212, the dense aromatic backbone of SPEEK efficiently rejected the crossover of electrolytes, with sulfonate groups housed within S p -DCX micropores increasing Na + mobility. SPEEK-SX2 exhibited 190 times higher Na + / Fe(CN) 6 4− selectivity and 6 times higher Na + / 2,6-DHAQ 2− selectivity compared to Nafion-212. This enabled stable operation for 600 cycles at a high current density of 160 mA cm −2 with only 0.00935% per cycle capacity decay. In contrast, the SPEEK membrane exhibited 0.07% per cycle decay, whereas Nafion-212 failed to run at this high current density.}, archive = {J_ANGEW}, author = {Wanqiao Liang and Ehsan Ghasemiestahbanati and Nathan T. Eden and Durga Acharya and Cara M. Doherty and Mainak Majumder and Matthew R. Hill}, doi = {10.1002/anie.202505383}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flow battery with remarkably stable performance at high current density: Development of a nonfluorinated separator with concurrent rejection and conductivity}, volume = {64}, year = {2025}, }
• (2025). Molecular geometry-property relationship of benzodipyrrole-based A-DA'D-A type acceptors for high-performance organic solar cells. ANGEW, 64(25), e202505366. (www)

  @article{ , abstract = {Molecular geometry plays a crucial role in determining the physical and chemical properties of organic semiconductor materials. However, there is little research on the molecular geometry-property relationship of A-DA'D-A type small molecule acceptors (SMAs), which are the most representative organic semiconductor materials used in organic solar cells (OSCs). In this work, we used dichlorine-substituted benzene as the A’ unit to overcome the geometry constraints imposed by the conventional A’ unit that has a large size. Four isomers of benzodipyrrole-based SMAs (C-Cl46-Cl, Ɂ-Cl46-Cl, M-Cl46-Cl, and S-Cl46-Cl) with C-, Ɂ-, M-, and S-shaped molecular geometries were synthesized, and the effect of molecular geometry on their photovoltaic performance was studied. We revealed that the molecular geometry influences the physicochemical and photovoltaic properties in three aspects: 1) intrinsic physicochemical properties, including energy levels, absorption, and reorganization energy; 2) molecular stacking pattern, which governs the exciton diffusion and charge transport processes; and 3) donor–acceptor interaction and miscibility. We found that the C-shaped molecular geometry possesses a suitable energy level and absorption range, dense and ordered molecular stacking, and improved donor–acceptor interaction and miscibility. These advantages enable a record-high power conversion efficiency (PCE) of 19.94% (certified as 19.54%) for the binary OSCs based on D18:C-Cl46-Cl active layer. The other SMAs showed weaknesses in different aspects, such as limited absorption of Ɂ-shaped SMA, large reorganization energies and loose molecular stacking of M-shaped SMA, low solubility and strong aggregation of S-shaped SMA. These properties resulted in inferior photovoltaic device performance. These findings on the molecular geometry-property relationships will be instructive for future molecular design of high-performance A-DA'D-A type SMAs.}, archive = {J_ANGEW}, author = {Yufei Gong and Senke Tan and Xiaojun Li and Shucheng Qin and Xiangjin Li and Tianwei Zou and Yuechen Li and Meng Yuan and Ziyue Zhang and Huawei Hu and Tongling Liang and Jinyuan Zhang and Lei Meng and Feng Liu and Yongfang Li}, doi = {10.1002/anie.202505366}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505366}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular geometry-property relationship of benzodipyrrole-based A-DA'D-A type acceptors for high-performance organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Ring-opening polymerization enables access to high-performance aliphatic-aromatic polyamides with chemical recyclability. ANGEW, 64(25), e202505310. (www)

  @article{ , abstract = {Although polyamides (PAs) have served as one of the most important engineering thermoplastics, it remains a long-standing challenge for chemical recycling of PAs to monomers. Herein, we report a facile approach to construct a series of benzo-fused caprolactams with various functionalities (BLM R ). These BLM R monomers underwent robust and well-controlled ring-opening polymerization to afford P(BLM R ) products with high thermal stability, enhanced water resistance, and tunable mechanical properties. Impressively, chemical recycling of P(BLM R ) to monomer could be accomplished with excellent efficiency in dilute solution at 100−150 °C with a mixed catalyst of t -BuOK and La[N(SiMe 3 ) 2 ] 3 , thus establishing a closed-loop circularity. The precise control of the polymerization and the recyclability of these semiaromatic polyamides promote a sustainable circular economy while offering the potential to access high-performance materials with tunable thermal and mechanical properties and enhanced water resistance.}, archive = {J_ANGEW}, author = {Xiang-Ting Tang and Jia-An-Qi Zhou and Yi-Min Tu and Hua-Zhong Fan and Meng-Yuan Wang and Qing Cao and Zhongzheng Cai and Jian-Bo Zhu}, doi = {10.1002/anie.202505310}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505310}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ring-opening polymerization enables access to high-performance aliphatic-aromatic polyamides with chemical recyclability}, volume = {64}, year = {2025}, }
• (2025). Catalytically active coacervates sustained out-of-equilibrium. ANGEW, 64(25), e202505296. (www)

  @article{ , abstract = {Metabolically active membraneless organelles of extant biology have the capability to maintain their structure under nonequilibrium conditions by leveraging chemical reactions. Herein, we report active coacervates accessed via a mixture of minimal building blocks that featured π-electron rich short peptide, positively charged aldehyde, and a cyclic ketone under nonequilibrium conditions. Peptide bound with the aldehyde by a dynamic covalent bond and demixed to form coacervates through hydrophobic interactions. Importantly, the short-peptide could utilize its free amine (β-alanine) to catalyze C─C bond formation which eventually led to the depletion of one of the building blocks (aldehyde) via aldol reaction; an intrinsic catalytic role that helped the coacervate to suppress coalescence. Notably, under continuous additions (open system) of the depleting precursors, the active coacervates were able to demonstrate spatial stability for longer duration. This out-of-equilibrium behavior of phase separated droplets in presence of flux of building blocks is reminiscent of the active membraneless organelles seen in contemporary biochemistry.}, archive = {J_ANGEW}, author = {Subhajit Bal and Saurabh Gupta and Chiranjit Mahato and Dibyendu Das}, doi = {10.1002/anie.202505296}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505296}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytically active coacervates sustained out-of-equilibrium}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of dactyloquinone a and spiroetherone a via a metal-hydride hydrogen atom transfer (MHAT) process and a Quinol–Enedione rearrangement. ANGEW, 64(25), e202505270. (www)

  @article{ , abstract = {We report the total synthesis of dactyloquinone A and spiroetherone A from a meroterpenoid scaffold obtained by the deconjugative alkylation of a Wieland–Miescher type ketone. For dactyloquinone A, we employed an intramolecular hydrofunctionalisation of the internal trisubstituted alkene with a quinone monoacetal via a metal-hydride hydrogen atom transfer (MHAT) process to form the key C─O bond. For spiroetherone A, we relied on a stereospecific quinol–spiroenedione rearrangement. The initially postulated structure of spiroetherone A was first synthesized, but was found to be different from the natural product. Finally, spiroetherone A was shown to be epimeric at the spirocyclic carbon. This finding was confirmed by total synthesis involving epimerization of the spirocycle via a late-stage singlet oxygen [4+2] cycloaddition to a cyclohexadiene derived from the initial enedione.}, archive = {J_ANGEW}, author = {Guillaume Schoenn and Cyrille Kouklovsky and Régis Guillot and Thomas Magauer and Guillaume Vincent}, doi = {10.1002/anie.202505270}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505270}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of dactyloquinone a and spiroetherone a via a metal-hydride hydrogen atom transfer (MHAT) process and a Quinol–Enedione rearrangement}, volume = {64}, year = {2025}, }
• (2025). Dynamic modulation of interactions between hydrophobic tag-conjugated DNA nanoprobes and cell membrane facilitates ATP imaging in the tumor microenvironment. ANGEW, 64(25), e202505223. (www)

  @article{ , abstract = {Conjugating hydrophobic tags to oligonucleotides facilitates the swift and efficient creation of membrane-anchored DNA nanoprobes. However, the membrane-anchoring of these hydrophobic tag-conjugated DNA nanoprobes (HT-DNPs) lacks specificity among different cell types. To address this challenge, we herein report a conformational switching-based strategy for selectively anchoring HT-DNPs to target cells. In our design, HT-DNPs with extended or compact conformations possess weak or strong interactions with cell membrane, respectively. Thus, interactions between HT-DNPs and cell membrane can be dynamically controlled by altering the conformation of HT-DNPs. Initially, the extended HT-DNPs exhibit poor membrane-anchoring ability that is impute to their weak hydrophobic interactions with cell membrane. However, in slightly acidic conditions, HT-DNPs intercalated with DNA i-motif-forming sequences can fold into a compact conformation and exhibit strong hydrophobicity, thus achieving selective and efficient anchoring of HT-DNPs to target cells in such environments. Utilizing this method, we constructed HT-DNPs for imaging of ATP in the tumor microenvironment (TME). Our results indicate that these HT-DNPs can effectively accumulate at tumor sites for specific ATP imaging following intravenous injection. This strategy paves new avenues for the selective and efficient functionalization of target cells with various membrane-anchored DNA nanostructures, including DNA nanoprobes, DNA nanocircuits, and DNA nanomachines.}, archive = {J_ANGEW}, author = {Qin Li and Linlin Wang and Wanlin Xie and Qingqing Tan and Su Zhou and Haimeng Pei and Hui Zhang and Jin Li and Fengli Qu and Weihong Tan}, doi = {10.1002/anie.202505223}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic modulation of interactions between hydrophobic tag-conjugated DNA nanoprobes and cell membrane facilitates ATP imaging in the tumor microenvironment}, volume = {64}, year = {2025}, }
• (2025). Functional ambidexterity of an ancient nucleic acid-binding domain. ANGEW, 64(25), e202505188. (www)

  @article{ , abstract = {The helix-hairpin-helix (HhH) motif is an ancient and ubiquitous nucleic acid-binding element that has emerged as a model system for studying the evolution of dsDNA-binding domains from simple peptides that phase separate with RNA. We analyzed the entire putative evolutionary trajectory of the HhH motif – from a flexible peptide to a folded domain – for functional robustness to total chiral inversion. Against expectations, functional “ambidexterity” was observed for both the phase separation of HhH peptides with RNA and binding of the duplicated (HhH) 2 -Fold to dsDNA. Moreover, dissociation kinetics, mutational analysis, and molecular dynamics simulations revealed an overlap between the binding modes adopted by the natural and mirror-image proteins to natural dsDNA. The similarity of several dissociation phases upon chiral inversion may reflect the history of (HhH) 2 -Fold binding, with the ultimate emergence of a high-affinity binding mode, supported by a bridging metal ion, depopulating but not displacing more primitive (potentially ambidextrous) modes. These data underscore the surprising functional robustness of the HhH protein family and suggest that the veil between worlds with alternative chiral preferences may not be as impenetrable as is often assumed.}, archive = {J_ANGEW}, author = {Orit Weil-Ktorza and Segev Naveh-Tassa and Yael Fridmann-Sirkis and Dragana Despotović and Kesava Phaneendra Cherukuri and Tatsuya Corlett and Yaakov Levy and Norman Metanis and Liam M. Longo}, doi = {10.1002/anie.202505188}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functional ambidexterity of an ancient nucleic acid-binding domain}, volume = {64}, year = {2025}, }
• (2025). Annulated radical cations with a C4E2-core (E = p, as, sb): Stable pnictogen analogs of elusive aryl radical anions of birch reduction reactions. ANGEW, 64(25), e202505142. (www)

  @article{ , abstract = {The benzene radical anion (C 6 H 6 ) ●− , possessing a 7π-electron count, is a crucial intermediate in the Birch reduction and has been extensively studied both experimentally and theoretically. Herein, we report the tricyclic pnictogen radical cations [(ADC)E] 2 [B], [ 2 -E][B] (ADC = PhC{N(Dipp)C} 2 ; Dipp = 2,6- i Pr 2 C 6 H 3 ; E = P, As, Sb; [B] = [B1] = B(C 6 F 5 ) 4 or [B2] = {3,5-(CF 3 ) 2 C 6 H 3 }) featuring a central 7π-electron planar C 4 E 2 ring embedded between two 1,3-imidazole-based anionic dicarbene (ADC) frameworks, as crystalline solids. [ 2 -E][B] are prepared by one-electron (1e) oxidations of the corresponding base-stabilized cyclic bis-pnictinidene compounds [(ADC)E] 2 ( 1 -E). Calculated spin densities (for E = P 76%, As 80%, Sb 88%) and EPR measurements suggest that [ 2 -E] ●+ are pnictogen-centered radicals and stabilized by the delocalization of the unpaired electron over the C 4 E 2 ring. The EPR spectra of [ 2 -E][B] exhibit characteristic signals for S = ½ systems with clear hyperfine coupling constants for the two similar P, As, or Sb nuclei. Further 1e-oxidations of [ 2 -E][B] result in the dicationic 6π-electron C 4 E 2 -species [(ADC)E] 2 [B] 2 [ 3 -E][B] 2 , which readily undergo comproportionations with 1 -E to afford [ 2 -E][B]. The radical reactivity of [ 2 -E][B2] is shown with 2,2,6,6-tetramethylpiperidinyloxyl (TEMPO) and diphenyl diselenide (PhSeSePh) in yielding compounds [(ADC) 2 E{E(TEMPO)}][B2] ( 4 -E) (E = P, Sb) and [(ADC) 2 P{P(SePh)}][B2] ( 5 -P), respectively.}, archive = {J_ANGEW}, author = {Henric Steffenfauseweh and Yury V. Vishnevskiy and Beate Neumann and Hans-Georg Stammler and Demi D. Snabilié and Bas de Bruin and Rajendra S. Ghadwal}, doi = {10.1002/anie.202505142}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505142}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Annulated radical cations with a C4E2-core (E = p, as, sb): Stable pnictogen analogs of elusive aryl radical anions of birch reduction reactions}, volume = {64}, year = {2025}, }
• (2025). Gallium-based eutectic alloys as liquid electron donors to ruthenium single-atom catalysts for selective hydrogenation of vanillin. ANGEW, 64(25), e202505073. (www)

  @article{ , abstract = {Tuning the catalytic pathways of atomically dispersed single-atom catalysts (SAC) has emerged as an effective strategy to optimize their overall catalytic activity. Herein, we present Ru 1 @m-tube, a hollow carbon nitride-supported Ru SAC, coated with eutectic galinstan (GaInSn), as a model catalyst, we demonstrate a performance inversion in vanillin conversion. Vanillin, as a biomass-derived compound with industrial relevance, presents challenges in catalytic hydrogenation, making it an ideal model reaction to test and compare the catalyst's selectivity and efficiency. The as-obtained Ru 1 @m-tube(GaInSn) achieved nearly 100% vanillin conversion within 5 h and exhibited an impressive 93.8% selectivity for vanillyl alcohol. Electron spillover from gallium-based eutectic alloys to highly diluted ruthenium sites enhances the desorption of vanillyl alcohol, resulting in an exceptional performance shift between hydrogenation and hydrodeoxygenation. Our findings not only offer a novel approach for modulating SAC performance via liquid–metal interfaces but also expand the understanding of promoter screening for various challenging reactions.}, archive = {J_ANGEW}, author = {Jia Song and Jianuo Liu and Xiaorong Zhu and Xiaoming Mou and Handuo Zheng and Huang Zhou and Wenyu Wang and Yong Guan and Jun Tang and Yue Lin and Lirong Zheng and Tao Yao and Juncai Dong and Shiqiang Wei and Weixin Huang and Lin Gu and Jun Luo and Yafei Li and Yafei Zhao and Yuen Wu}, doi = {10.1002/anie.202505073}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gallium-based eutectic alloys as liquid electron donors to ruthenium single-atom catalysts for selective hydrogenation of vanillin}, volume = {64}, year = {2025}, }
• (2025). Modulating active hydrogen supply and o2 adsorption: Sulfur vacancy matters for boosting H2O2 photosynthesis performance. ANGEW, 64(25), e202505046. (www)

  @article{ , abstract = {Photocatalytic two-electron oxygen reduction reaction (2e − ORR) represents a promising approach for H 2 O 2 production. However, the lack of photocatalysts with appropriate O 2 adsorption and hydrogenation capabilities impedes the H 2 O 2 production performance. Herein, we report the synthesis of Ni-doped ZnS hollow nanocubes with S vacancies (Ni-ZnS-Sv) as a dual-site 2e − ORR photocatalyst for efficient H 2 O 2 production. Experimental results and density functional theory calculations reveal the vital roles of Sv in modulating the electronic structures of Ni and S dual sites toward enhanced 2e − ORR selectivity and activity. The atomically dispersed Ni sites with electron-rich state enable a Pauling-type (end-on) O 2 adsorption configuration and a modest binding strength of O 2 and OOH*, largely avoiding the O─O bond cleavage. Besides, the formation of electron-deficient S sites weakens the S─H ads bond, facilitating *H ads migration to adjacent Ni sites and accelerating the hydrogenation kinetics of O 2 to OOH* intermediate. As a result, the elaborately designed Ni-ZnS-Sv photocatalyst exhibits a high H 2 O 2 yield of 5649.49 µmol g −1 h −1 under UV–vis light irradiation in pure water. Our work offers new insights into the design principles of high-performance photocatalysts for artificial H 2 O 2 photosynthesis systems.}, archive = {J_ANGEW}, author = {Yamin Xi and Chaoqi Zhang and Wenjing Tu and Yuntian Guo and Tong Bao and Yingying Zou and Chao Liu and Chengzhong Yu}, doi = {10.1002/anie.202505046}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202505046}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating active hydrogen supply and o2 adsorption: Sulfur vacancy matters for boosting H2O2 photosynthesis performance}, volume = {64}, year = {2025}, }
• (2025). Regulating interfacial molecular configuration to drive facet-selective zn metal deposition. ANGEW, 64(25), e202504965. (www)

  @article{ , abstract = {The direct use of metal anode emerges as a key strategy in advancing high-energy-density batteries, applicable across non-protonic, aqueous, and solid-state battery systems. To enhance battery durability, one effective approach involves employing interfacial molecular modification to modulate metal's facet orientation, reducing the tendency of metals to form random and loose morphologies during deposition. Herein, we propose a model to elucidate how dicarboxylic acid molecules with varying alkyl chain lengths modulate their adsorption behavior and deposition rate on zinc (Zn) surfaces, achieving facet-selective Zn deposition. Taking glutaric acid (GA) as an example, its medium alkyl chain length allows for a “flat-lying” adsorption configuration on Zn(002) surface, resulting in strong adsorption and Zn-GA metal-molecule bridging interface. This regulates Zn 2+ diffusion process and restricts its accessibility to Zn(002) facet, facilitating the selective exposure of Zn(002) facet. Due to this design, the Zn||Zn symmetric cell stably operates at a high current density of 20 mA cm −2 and a high depth of discharge of 85%. The Zn||MnO 2 pouch cell achieves a high capacity of 1.1 Ah with 90% capacity retention. This metal-molecule interface design can be extended to other metal anodes, with the potential for tailored molecular selections to regulate the selective growth of crystal facets.}, archive = {J_ANGEW}, author = {Yue Ouyang and Wei Zong and Xuan Gao and Shi Xuan Leong and Jaslyn Ru Ting Chen and Yuhang Dai and Haobo Dong and In Yee Phang and Paul R. Shearing and Guanjie He and Yue-E Miao and Tianxi Liu and Xing Yi Ling}, doi = {10.1002/anie.202504965}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504965}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating interfacial molecular configuration to drive facet-selective zn metal deposition}, volume = {64}, year = {2025}, }
• (2025). Tandem dual-ratiometric SERS probe enables raman imaging of neurological pH fluctuations in epilepsy. ANGEW, 64(25), e202504822. (www)

  @article{ , abstract = {An imbalance of brain pH is closely associated with biochemical reactions, ion regulation, and electrical activity, serving as a hallmark for various neurological disorders. High-resolution imaging of pH fluctuations in brain disease is crucial for understanding pathological processes. However, current pH probes are inadequate for this purpose due to poor blood-brain barrier (BBB) penetration or insufficient specificity. Herein, we reported a tandem dual-ratiometric surface-enhanced Raman scattering (SERS) probe, RHP@AuS , capable of crossing the BBB to address these challenges. RHP@AuS leveraged dendrimers for the facile one-step synthesis of SERS probes, significantly enhancing signal intensity and reproducibility. RHP@AuS can be sequentially activated by neuroinflammation-associated H 2 O 2 and pH, exhibiting highly selective ratiometric responses to pH fluctuations in brain disease. Dynamic SERS imaging revealed that during neuronal epileptic activity, inflammation increased and local pH dropped sharply to around 6.6. Building on these findings, a drug combination with dual neuroinflammation-mitigating and pH-regulating properties was developed, effectively alleviating epilepsy in mouse models. This study opens new avenues for developing imaging probes for the brain and deepens our understanding of the roles of pH in neurological disorders.}, archive = {J_ANGEW}, author = {Jing Zhao and Yuncan Chen and Yurui Tang and Bohan Li and Qinyue Wang and Junfeng Wang and Xihui Gao and Yunle Zhang and Jing Wang and Zuhai Lei and Cong Li and Cong Wang}, doi = {10.1002/anie.202504822}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504822}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem dual-ratiometric SERS probe enables raman imaging of neurological pH fluctuations in epilepsy}, volume = {64}, year = {2025}, }
• (2025). Iron-catalyzed reductive allylic C─H amination of olefin with nitroarenes via intermolecular nitroso ene reaction. ANGEW, 64(25), e202504750. (www)

  @article{ , abstract = {Aromatic allylamines are essential in the synthesis of diverse pharmaceutical building blocks. While oxidative allylic C─H amination using anilines has advanced significantly, achieving intermolecular reductive allylic C─H amination of olefins with readily available nitroarenes remains a considerable challenge. Here, we demonstrate that replacing silanes with a combination of protons and electrons enables selective reductive allylic C─H amination, avoiding the competing hydroamination pathway. The key to this transformation is the use of 2,2,2-trifluoroethanol (TFE) as the solvent. This process complements previous oxidative allylic C─H amination by eliminating the need for noble metal catalysts while tolerating oxidizable or nucleophilic functional groups. Notably, this method facilitates the functionalization of bioactive compounds, underscoring its potential in medicinal chemistry. Furthermore, by leveraging its reactivity with trisubstituted olefins, this approach, when combined with metal hydride atom transfer (MHAT) reactions, offers a unique strategy for regioselective and modular difunctionalization of aliphatic olefins. Experimental and computational mechanistic studies highlight the crucial roles of TFE in stabilizing the nitrosoarene intermediate and promoting the key nitroso-ene step.}, archive = {J_ANGEW}, author = {Shaolong Qi and Duren Yin and Lingfei Hu and Changqin Huang and Ruyu Xie and Gang Lu and Jianchun Wang}, doi = {10.1002/anie.202504750}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504750}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron-catalyzed reductive allylic C─H amination of olefin with nitroarenes via intermolecular nitroso ene reaction}, volume = {64}, year = {2025}, }
• (2025). Hydride-richest molecular complex: Ligand-length facilitated Cu40H38 nanoclusters exhibiting high catalytic performance for selective hydrogenation. ANGEW, 64(25), e202504671. (www)

  @article{ , abstract = {Copper hydride clusters are extensively studied for their significant potential catalysis. Although clusters with a high hydride content are particularly intriguing, they present considerable synthetic challenges. Herein, we report two copper hydride clusters, Cu 18 H 16 and Cu 40 H 38 , which exhibit similar layered structures and components, albeit differing in size. The larger-sized Cu 40 H 38 with more hydrides was achieved through ligand-length modulation by replacing 1,2-bis(diphenylphosphino)ethane (dppe) in the synthesis of Cu 18 H 16 with 1,5-bis(diphenylphosphino)pentane (dpppe). Cu 40 H 38 is remarkable for i) the highest number of hydrides among known molecular compounds, ii) the highest number of unligated copper atoms and the highest metal-to-ligand ratio in copper hydride clusters. Moreover, catalytic studies on the selective hydrogenation of α,β-unsaturated carbonyl compounds demonstrate that Cu 40 H 38 is a promising catalyst and provide clear structural evidence that a less sterically hindered cluster surface, with a high metal-to-ligand ratio, is beneficial for high-performance catalysis. The findings highlight the importance of surface composition and ligand coverage in catalytic efficiency and offer new avenues for designing high-performance copper hydride cluster catalysts.}, archive = {J_ANGEW}, author = {Jie Zhou and Wen-Wen Zhan and Yan Li and Xin-Rui Gao and Chengkai Zhang and Di Sun and Yang Yang}, doi = {10.1002/anie.202504671}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504671}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydride-richest molecular complex: Ligand-length facilitated Cu40H38 nanoclusters exhibiting high catalytic performance for selective hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Boosting electrocatalytic nitrogen reduction on cobalt-based perovskite via regulating reaction pathway through donation-back-donation modulation. ANGEW, 64(25), e202504601. (www)

  @article{ , abstract = {The electrocatalytic approach of combining N 2 and H 2 O to produce ammonia, known as the electrocatalytic N 2 reduction reaction (eNRR), has garnered significant attention due to its environmental benefits and potential for supporting a decentralized agricultural economy. However, the underlying chemistry governing the reaction pathways remains poorly understood, hindering the design of low-cost and efficient eNRR catalysts. Here we report the enhancement of the electrocatalytic eNRR activity of perovskite oxides by tuning the reaction pathway through a “donation-back-donation” mechanism. This is achieved by controlling the spin state via adjusting the distribution of d orbital electrons in low-cost transition metals, such as cobalt. Specifically, the cobalt in perovskite SrCoO 3 (SC) with a low-spin state demonstrates an 18 times higher ammonia yield rate compared to that in Co 3 O 4 and 1.5 times higher than cobalt in perovskite LaCoO 3 (LC). The low spin states of cobalt in SC enable better control of the eNRR reaction pathway over the transformation of *N 2 H to *NHNH or *NNH 2 , resulting in alternating hydrogenation in SC rather than distal hydrogenation in LC with a high spin state. The unprecedented improvement in eNRR by regulating the spin state of Co demonstrates the bright of low-cost Co-based electrocatalysts for ammonia production.}, archive = {J_ANGEW}, author = {Ning Han and Wei Zhang and Jianxiang Wu and Kaibin Chu and Shihui Feng and Shuo Wang and Alain R. Puente-Santiago and Jinlin Long and Bo Weng and Bao-Lian Su}, doi = {10.1002/anie.202504601}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504601}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting electrocatalytic nitrogen reduction on cobalt-based perovskite via regulating reaction pathway through donation-back-donation modulation}, volume = {64}, year = {2025}, }
• (2025). Phthalocyanine grafting strategy induces strong intrinsic electric fields and molecule-edge carrier transport pathways for photoelectrochemical water splitting. ANGEW, 64(25), e202504589. (www)

  @article{ , abstract = {Limited charge separation, slow charge mobility, and high electron-hole recombination rates remain critical challenges impeding the efficiency of photoelectrochemical (PEC) water splitting. More regrettably, the charge transfer pathways within bulk charge transport are not yet fully understood, and the development of effective strategies to design these pathways remains a significant challenge. Herein, by optimizing the anchoring sites of small molecular ligands, we developed a molecularly functionalized layer, 4-ethyl-carbazole copper phthalocyanine (4EtCz-Pc), which is characterized by a strong dipole moment, a large internal electric field, and surprisingly positive electrostatic potential at the edge. When integrated in conjunction with the oxygen evolution cocatalyst (OEC) and the semiconductor photoanode BiVO 4 (BVO), it forms a Co(OH)₂/4EtCz-Pc/BiVO 4 composite photoanode system. This innovative photoanode demonstrates an exceptional performance with continuous output for a duration of 15 h. Additionally, a variety of advanced characterization methods, especially scanning photoelectrochemical microscopy (SPECM) analyses, confirmed that 4EtCz-Pc significantly reduces the energy barrier for hole injection from the anode to the active layer during PEC catalysis. This study proposes an effective strategy to optimize the ligands grafted onto phthalocyanine, generating a strong internal electric field that facilitates the formation of new charge transport pathways within the photoanode.}, archive = {J_ANGEW}, author = {Wei Luo and Hui Xiao and Shengya Zhang and Ze Wang and Rongfang Zhang and Jianbin Xue and Yanjun Feng and BingZhang Lu and Peiyao Du and Xiaoquan Lu}, doi = {10.1002/anie.202504589}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phthalocyanine grafting strategy induces strong intrinsic electric fields and molecule-edge carrier transport pathways for photoelectrochemical water splitting}, volume = {64}, year = {2025}, }
• (2025). A joyful journey: Tungsten(VI) and Tungsten(V) fluorides meet N-heterocyclic carbenes and cyclic (Alkyl)(Amino)Carbenes. ANGEW, 64(25), e202504498. (www)

  @article{ , abstract = {The first complexation of tungsten(VI) fluoride with N -heterocyclic carbenes (NHCs) and a cyclic (alkyl)(amino) carbene (cAAC Me ) is reported, which led to formation of the complexes [(NHC)WF 6 ] (NHC = I i Pr Me , 1 ; BI i Pr, 2 ; IMes, 3 ; IDipp, 4 ; and SIDipp, 5 ) and [(cAAC Me )WF 6 ] 6 . Solid-state structural analysis revealed distorted mono-capped trigonal prismatic geometries for 2 and 3 , whereas 6 adopts a pentagonal bipyramidal coordination. Reduction of 1 – 6 with 0.5 equivalents of TMS-pyr Me -TMS afforded rare tungsten(V) fluoride complexes [(NHC)WF 5 ] (NHC = I i Pr Me , 7 ; BI i Pr, 8 ; IMes, 9 ; IDipp, 10 ; and SIDipp, 11 ). Reduction of 6 with TMS-pyr-TMS yielded the dinuclear, fluoride-bridged complex [(cAAC Me )WF 5 ] 2 12 . Subsequent addition of a second equivalent cAAC Me to 12 gave the mononuclear, seven-coordinated bis-carbene complex [(cAACMe) 2 WF 5 ] 13 . Magnetic susceptibility measurements and EPR spectroscopy confirm a predominantly metal-centered d¹ radical in both 12 and 13 . These findings expand the scope of tungsten fluoride chemistry by providing rare examples of tungsten(VI) and tungsten(V) complexes stabilized by soft carbon-donor ligands, paving the way for further exploration.}, archive = {J_ANGEW}, author = {Melanie Riethmann and Leonhard Eyßelein and Ivo Krummenacher and Rüdiger Bertermann and Holger Braunschweig and Michael Gerken and Maik Finze and Udo Radius}, doi = {10.1002/anie.202504498}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504498}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A joyful journey: Tungsten(VI) and Tungsten(V) fluorides meet N-heterocyclic carbenes and cyclic (Alkyl)(Amino)Carbenes}, volume = {64}, year = {2025}, }
• (2025). Controlled growth of oligophenylene-structures on graphene for facile secondary functionalization. ANGEW, 64(25), e202504482. (www)

  @article{ , abstract = {Functionalization of graphene derivatives is a common approach to tune material properties for use in various applications. Because of the low reactivity of the unsaturated carbon lattice of graphene, not only are few chemical approaches suitable for successful functionalization, such as those involving highly reactive in situ formed radical species or nitrene and carbene compounds, but also the degree of functionalization is usually limited, modifying only a few percent of the carbon atoms. Typically, uncontrolled side reactions such as homocoupling and oligomerization of newly introduced functional groups can occur instead of direct coupling to the carbon lattice. We want to turn this unwanted side reaction into an advantage and use intentionally formed covalent dendrimeric oligophenylene structures for secondary functionalization. We show that these oligomeric structures can be grown to specific thicknesses and used for further functionalization with bromomethyl groups at high density on the surface. This functionalization opens further avenues for subsequent nucleophilic substitution, as exemplified by the introduction of versatile azide, nitrile, and phosphonate groups. The results presented here are not only applicable to large oligophenylene structures, but also demonstrate that, in principle, single aryl moieties on graphene of any size and density can be successfully functionalized.}, archive = {J_ANGEW}, author = {Christian E. Halbig and Felix Fels and Shenquan Wei and Robert Schusterbauer and Ievgen Donskyi and Markus R. Heinrich and Siegfried Eigler}, doi = {10.1002/anie.202504482}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504482}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled growth of oligophenylene-structures on graphene for facile secondary functionalization}, volume = {64}, year = {2025}, }
• (2025). Temporary structural supports for chemical protein synthesis. ANGEW, 64(25), e202504405. (www)

  @article{ , abstract = {The range of functional proteins that can be prepared by chemical protein synthesis includes those bearing complex modifications and incorporating d -amino acids, and exceeds what can be accessed by biological means, but the technique is still limited by the unfavorable solution behavior of many synthetic protein intermediates in buffer, leading to inefficient ligation, purification, and in vitro folding. One approach to address this limitation is the use of temporary structural supports—chemical modifications, usually solubilizing functionalities such as polyamines or carbohydrates—that are installed on either the backbone or side chains of the synthetic protein intermediates and removed at a later stage of chemical protein synthesis. The basic processes for introducing and removing such temporary structural supports are reminiscent of the canonical protecting groups ubiquitous in organic chemistry. However, unlike the synthesis of small organic molecules, where solubility is rarely an issue, the purpose of temporary structural supports is to modulate the solution behavior of the synthetic protein intermediates to prevent them from aggregation, precipitation, or retention in unfavorable solvation-phase conformations. In this review, we summarize recent advances in the development of temporary structural supports for chemical protein synthesis and organize them into three categories: 1) Temporary structural supports to improve solubility; 2) Temporary structural supports to assist chemical ligation; and 3) Temporary structural supports to promote in vitro folding.}, archive = {J_ANGEW}, author = {Yanbo Liu and Dongyang Han and Lei Liu}, doi = {10.1002/anie.202504405}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504405}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Temporary structural supports for chemical protein synthesis}, volume = {64}, year = {2025}, }
• (2025). A metal-organic framework with tailored shape-matched interactions towards ambient-temperature argon removal for oxygen purification. ANGEW, 64(25), e202504324. (www)

  @article{ , abstract = {High-purity oxygen (O 2 ) is essential for high-value-added applications in the medical, aerospace, and electronics sectors. The production of high-purity O 2 via non-thermal-driven pressure-swing adsorption has the advantages of portable operation and low energy consumption. However, effectively removing trace amounts of argon (Ar) impurities in this process is indispensable, and it is a fundamental challenge to achieve the preferential adsorption of inert Ar atoms over polar O 2 molecules instead of traditional thermodynamic or molecule sieving strategies. Herein, we have demonstrated this problem was addressed by integrating spheroidal shape-matched interactions to fit the spheroid Ar atoms while repulsing the linear O 2 molecules. Using this strategy, customized TYUT-20 enables the exceptional recognition of Ar atoms over O 2 molecules, demonstrating an unprecedented Ar adsorption capacity of up to 14.5 cm 3 g −1 and a top-performing Ar/O 2 (1.54) selectivity at 298 K and 1 bar. The Ar atom recognition mechanism on this adsorbent has been investigated using Ar-loaded single crystal diffraction analysis and molecular simulation studies. The productivity of high-purity O 2 (>99.99%) from a 5/95 Ar/O 2 mixture breakthrough experiment reached 6.6 L kg −1 under ambient conditions, which highlighted TYUT-20 as a very promising adsorbent in ready-to-use high-purity O 2 production.}, archive = {J_ANGEW}, author = {Puxu Liu and Jianhui Li and Furong Yan and Jing-Hong Li and Lifei Yin and Yutao Liu and Yang Chen and Rui-Biao Lin and Jinping Li and Xiao-Ming Chen and Libo Li}, doi = {10.1002/anie.202504324}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504324}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A metal-organic framework with tailored shape-matched interactions towards ambient-temperature argon removal for oxygen purification}, volume = {64}, year = {2025}, }
• (2025). Artificial Cation–Chloride co-transporters for chloride-facilitated Lithium/Magnesium separation. ANGEW, 64(25), e202504259. (www)

  @article{ , abstract = {Inspired by nature, many artificial ion sieving materials have been developed, shedding light on the next-generation ion, e.g., Li + , extraction applications. Artificial co-transporters remain difficult to construct since they have a much more complex ion-sieving property. For example, the cation–chloride co-transporters have both alkaline ion and chloride ion selectivity but no alkaline ion/chloride ion selectivity. We here demonstrate a method to construct artificial co-transporters, using a porous organic framework membrane which has a relatively disordered stacking structure and rich quaternary ammonium groups paired with counter-ions. This imparts the membrane with extremely narrow pores (∼0.3 nm) and almost no surface charge, enabling size-based high alkaline ion selectivity against other cations, high Cl − selectivity against other anions, but almost no alkaline ion/Cl − selectivity. Such synchronized sieving property allows us to enhance the extraction of high-value cations (Li + ) by simply feeding excessive low-value anions (Cl − ). As a demonstration, we realized high-flux (0.44 mol m −2 h −1 ) and highly selective (selectivity: 185) Li + /Mg 2+ separation by reversing the current industrial brine-based lithium extraction process, i.e., sieving Li + before removing NaCl.}, archive = {J_ANGEW}, author = {Yushuang Hou and Chenguang Zhu and Haozhe Sun and Yongye Zhao and Shangfa Pan and Shuhui Ma and Qianqian Fu and Xin Sui and Xueli Liu and Lei Jiang and Jun Gao}, doi = {10.1002/anie.202504259}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial Cation–Chloride co-transporters for chloride-facilitated Lithium/Magnesium separation}, volume = {64}, year = {2025}, }
• (2025). Photoelectrochemical Iron(III) catalysis for late-stage C─H fluoroalkylations. ANGEW, 64(25), e202504143. (www)

  @article{ , abstract = {Chemo- and site-selective functionalization of complex molecules poses a fundamental challenge. Herein, we introduce a resource-economic photoelectrocatalysis strategy to enable versatile direct fluoroalkylations catalyzed by Earth-abundant iron and paired with the hydrogen evolution reaction (HER). Notably, the devised approach proved amenable to versatile late-stage C─H fluoroalkylations of bio-relevant heterocycles, such as xanthines, nucleobases, and nucleosides. Mechanistic studies supported a ligand-to-metal charge transfer-induced formation of the fluoroalkyl radical.}, archive = {J_ANGEW}, author = {Vladimir Motornov and Sven Trienes and Simonetta Resta and João C. A. Oliveira and Zhipeng Lin and Zhi Liu and Tristan von Münchow and Claudia Stückl and Lutz Ackermann}, doi = {10.1002/anie.202504143}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504143}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoelectrochemical Iron(III) catalysis for late-stage C─H fluoroalkylations}, volume = {64}, year = {2025}, }
• (2025). Mn2+-activated alkali lithooxidosilicate phosphors as sustainable alternative white-light emitters. ANGEW, 64(25), e202504078. (www)

  @article{ , abstract = {Eu 2+ -activated alkali lithooxidosilicates have emerged as promising candidates for narrow-band cyan and green-emitting phosphors for human-centered lighting. Despite the vivid research on Eu 2+ -activated alkali lithooxidosilicates, little to nothing is known about the possible luminescence with other activator ions than Eu 2+ . The more abundant transition metal ion Mn 2+ is a potential alternative emitter with tunable emission over the visible spectral range. Mn 2+ -activated alkali lithooxidosilicates show two emission bands in the green and red spectral range, respectively, making them intriguing candidates for one-component phosphor-converted white light-emitting diodes. A total of seven Mn 2+ activated compounds were prepared to elucidate possible trends. The results show that the ratio between green and red emission correlates to the size of the available activator sites and is easily controlled by the composition of the alkali lithooxidosilicate host compounds. Temperature-dependent luminescence studies reveal that thermal quenching occurs slightly above room temperature for those compounds, which may be connected to the comparably low band gaps for silicates ( E g < 6 eV) and a consequent thermal ionization of excited electrons into the conduction band. Overall, this study comprises the first class of compounds with efficient tailored white-light emission based on Mn 2+ within one host compound.}, archive = {J_ANGEW}, author = {Lukas Maximilian Träger and Judith Ifeoma Ekeya and Annika Liesenfeld and Marc Wieczorek and Hubert Huppertz and Markus Suta}, doi = {10.1002/anie.202504078}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504078}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mn2+-activated alkali lithooxidosilicate phosphors as sustainable alternative white-light emitters}, volume = {64}, year = {2025}, }
• (2025). MOF catalysts for plastic depolymerization. ANGEW, 64(25), e202504017. (www)

  @article{ , abstract = {Depolymerization is a promising solution to address the escalating global plastic waste crisis, as a key enabler for emerging technologies in chemical upcycling and closed-loop recycling of plastics. By virtue of their unparalleled bottom-up designability for structural control, stability, reactivity, and compatibility with catalytically-active metal nanoparticles and enzymes, MOFs have enormous potential as an emerging class of porous heterogeneous catalysts for plastics depolymerization. Herein, we highlight key considerations and advances in MOF catalyst development and design for a range of depolymerization reactions, including alcoholysis, hydrogenolysis, pyrolysis, photocatalytic oxidation, and enzymatic hydrolysis. Other than enabling MOFs to efficiently depolymerize the most abundant plastics in production today, including those with unreacted C─C backbones (e.g., polyolefins) and polymers with cleavable backbone linkages (e.g., polyesters), their versatility also extends to emerging applications in microplastic capture and degradation from wastewater. These unique properties of MOFs position them as potentially scalable and reusable heterogeneous catalysts that can complement existing inorganic catalysts for practical depolymerization.}, archive = {J_ANGEW}, author = {Bao-Nguyen T. Nguyen and Tristan T. Y. Tan and Ken-ichi Otake and Susumu Kitagawa and Jason Y. C. Lim}, doi = {10.1002/anie.202504017}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202504017}, shortjournal = {Angew. Chem. Int. Edit.}, title = {MOF catalysts for plastic depolymerization}, volume = {64}, year = {2025}, }
• (2025). A novel synthetic pathway to lanthanide triple-decker complexes: Selective expansion of a sandwich complex by an insertion reaction. ANGEW, 64(25), e202503942. (www)

  @article{ , abstract = {Commonly, multi-decker sandwich complexes can either be formed in a one-step reaction or in a stepwise fashion by stacking deck by deck. Herein, we showcase a new reaction pathway, in which for the first time a lanthanide half-sandwich unit inserts into an existing sandwich complex. As a result of the insertion of a cyclocene half-sandwich fragment {Ln II ( η 8 -Cot TIPS )} (Cot TIPS = 1,4-( i Pr 3 Si) 2 C 8 H 6 2− ) into a classical divalent sandwich complex [Ln II ( η 9 -Cnt) 2 ] (Ln = Sm, Eu, Yb; Cnt = C 9 H ), the unprecedented triple-decker sandwich complexes of the type [( η 9 -Cnt)Ln II ( μ - η 8 :η 8 -Cot TIPS )Ln II ( η 9 -Cnt)] were obtained. A plausible reaction pathway was determined by quantum chemical calculations. Additionally, we synthesize the same lanthanide sandwich complexes in a traditional, stepwise fashion. For this, we initially present the novel inverse sandwich compounds [Ln II I(thf) 2 ( μ - η 8 :η 8 -Cot TIPS )Ln II I(thf) 2 ] (Ln = Sm, Eu, thf = tetrahydrofuran) and [Yb II (BH 4 )(thf) 2 ( μ - η 8 :η 8 -Cot TIPS )Yb II (BH 4 )(thf) 2 ] consisting of a cyclooctatetraene middle deck sandwiched between two divalent lanthanides as precursors. Subsequent salt metathesis reactions with [K(Cnt)] (Cnt = C 9 H ) gave rise to the title compounds [( η 9 -Cnt)Ln II ( μ - η 8 :η 8 -Cot TIPS )Ln II ( η 9 -Cnt)]. The unique feature of these compounds is the combination of the two largest aromatic all-carbon rings known in coordination chemistry—the 8- and 9-membered rings—into lanthanide triple-decker sandwich compounds.}, archive = {J_ANGEW}, author = {Cedric Uhlmann and Luca Münzfeld and Adrian Hauser and Sebastian Gillhuber and Pauline Hädinger and Maxim Leskov and Florian Weigend and Peter W. Roesky}, doi = {10.1002/anie.202503942}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503942}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A novel synthetic pathway to lanthanide triple-decker complexes: Selective expansion of a sandwich complex by an insertion reaction}, volume = {64}, year = {2025}, }
• (2025). Facile synthesis of polyorganosiloxanes via photo-induced anionic ring-opening polymerization using a latent catalyst. ANGEW, 64(25), e202503923. (www)

  @article{ , abstract = {Precise, controlled, and living polymerization of cyclosiloxanes is garnering considerable attention due to the distinct properties and promising applications of polyorganosiloxanes in various fields. In this contribution, photo-induced living anionic ring-opening polymerization of cyclosiloxanes is achieved by developing an efficient photobase generator (PBG). Structure-photoactivity analysis of the photo-latent catalyst is undertaken by synergistic density functional theory (DFT) calculations and experimental investigations. DFT calculations predict the superior photoactivity of the synthesized PBG2 (i.e., 2-[(9-oxo-9H-thioxanthen-2-yl)oxy]acetic-1,5,7-riazabicyclo[4.4.0]dec-5-ene) and provide insights into the structure-catalytic activities, which is confirmed through the experiments. Polyorganosiloxanes with predetermined molar masses and low dispersities ( Đ < 1.30) are produced through on-demand cleavage of PBG2 under various light intensities, different PBG2 loadings, and sequential addition of monomers. On–off light switching enables the polymerization in a rate-controlled manner. Later on, mechanistic insights by DFT calculations identify the anionic species for nucleophilic attack and reveal that the reversible equilibrium involving anionic species, catalyst cations, and ion pairs contributes to precise control over chain growth during photopolymerization. Furthermore, deterministic kinetic simulation disentangles the effects of the cleavage rate and loading of PBG2 on polymerization kinetic behaviors. This developed photopolymerization strategy shows promising potential to expand the application of polyorganosiloxanes in advanced manufacturing fields.}, archive = {J_ANGEW}, author = {Wenxu Zhang and Tian-Tian Wang and Shen Li and Chunhui Zhao and Chao Bian and Yin-Ning Zhou and Zheng-Hong Luo}, doi = {10.1002/anie.202503923}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facile synthesis of polyorganosiloxanes via photo-induced anionic ring-opening polymerization using a latent catalyst}, volume = {64}, year = {2025}, }
• (2025). Sustainable and simple water-induced separation of ionic liquid mixtures. ANGEW, 64(25), e202503863. (www)

  @article{ , abstract = {Ionic liquids (ILs) are often considered inseparable once mixed, posing a major challenge for their reuse and recycling. We demonstrate a simple and effective method to separate ILs containing hydrophobic ([NTf 2 ] − ) and hydrophilic ([OAc] − ) anions under ambient conditions. This process is driven by the thermodynamic behavior of the ILs in presence of water that enables the near-complete (⩾99%) recovery of pure components without complex purification steps. Our findings prove that pure ILs can easily be recovered after being mixed and open new pathways for the sustainable use of ionic fluids in various applications.}, archive = {J_ANGEW}, author = {Beatriz R. de Moraes and Agilio Pádua and Rômulo A. Ando and Margarida Costa Gomes}, doi = {10.1002/anie.202503863}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503863}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sustainable and simple water-induced separation of ionic liquid mixtures}, volume = {64}, year = {2025}, }
• (2025). Photoactivated enzymatic reaction network enables spatiotemporal programming of Thiol/Disulfide redox systems. ANGEW, 64(25), e202503822. (www)

  @article{ , abstract = {Implementing photoactivation into chemical reaction networks (CRNs) offers opportunities for on-demand and remote activation, fuel storage, creating autonomous materials and systems with precise spatial activation. However, examples in this domain remain limited. Here, we introduce a cascaded redox-based enzymatic reaction network (ERN) capable of photoinitiation and refueling, centered around dissipative aromatic disulfide bond formation. To achieve photoinitiation, we integrate an upstream enzymatic module (EM) into the ERN, where the substrate of the EM can be photouncaged using blue light irradiation. A downstream regeneration system enhances the robustness of the reducing environment for repeated fueling. This cascaded ERN operates in solution, allowing for controlled dissipative disulfide formation while avoiding short-circuit reactions (SCR) between the oxidative and reductive halves of the reaction cycle. To showcase the utility of this photoactivated ERN, we couple it with aromatic thiol-terminated star polymers (sPEG-ArSH) to enable spatiotemporally controlled dissipative hydrogel formation using lithographic masks.}, archive = {J_ANGEW}, author = {Aritra Sarkar and Piet J. M. Swinkels and Lea Duttenhofer and Pol Besenius and Andreas Walther}, doi = {10.1002/anie.202503822}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503822}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoactivated enzymatic reaction network enables spatiotemporal programming of Thiol/Disulfide redox systems}, volume = {64}, year = {2025}, }
• (2025). Erasable fluorescence imaging technology enables continuous tracking for identical living cells. ANGEW, 64(25), e202503818. (www)

  @article{ , abstract = {Subtle molecular events may trigger a cascade of “butterfly effects” to reverse cell fate, so dynamic tracking of relevant markers can provide crucial clues to decipher the unknown. However, existing analytical techniques are still at static-analysis level, and cutting-edge fluorescence imaging is limited by signal interference at adjacent time, failing to realize continuous observation for identical live cells. Herein, we develop a new temperature-controlled imaging technology, where melamine-mediated reversible DNA self-assembly drives the fluorescence illuminating and extinguishing at any time, achieving repeated erasable imaging for identical living cells. This method can track cell behaviors by taking dynamic monitoring of cell differentiation as an example, and timely fluorescence erasing guarantees authenticity for imaging results and minimizes interference with cellular activities. Thanks to high feasibility in fundamental experimental scenarios, this method hopefully provides a powerful preliminary screening tool for exploring new biological mechanisms in cell interactions, developmental transformations, downstream response inquiry, and so forth.}, archive = {J_ANGEW}, author = {Yanan Peng and Qiumei Pu and Liangqing Lu and Qionglin Zhou and Xinxin Xiao and Xiangde Lai and Xuan Zhao and Bin Qiao and Qiang Wu}, doi = {10.1002/anie.202503818}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503818}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Erasable fluorescence imaging technology enables continuous tracking for identical living cells}, volume = {64}, year = {2025}, }
• (2025). Pangenome analysis of the plant pathogen pseudomonas syringae reveals unique natural products for niche adaptation. ANGEW, 64(25), e202503679. (www)

  @article{ , abstract = {Pseudomonas syringae is a soil-dwelling bacterium that exhibits remarkable niche adaptability, and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologically active natural products. P. syringae coexists with amoebal predators and fungal strains, which drives the production of secondary metabolites for predator evasion in addition to niche adaptation. In this study, we conducted a broad pangenomic analysis of 18 taxonomically distinct P. syringae strains, leading to the identification of 231 biosynthetic gene clusters (BGCs). Among these, nonribosomal peptide synthetases (NRPSs) were particularly abundant, indicating their potential significance within this ecological context. We discovered and elucidated the structures of two novel classes of bioactive compounds, the syrilipamides and chlorosecimides. Furthermore, a bioinformatic analysis enabled the identification of an undescribed halogenase, SecA, essential for the chlorination of secimide A. We observed that syrilipamides and secimides and in particular mixtures thereof, exhibit amoebicidal activities. Additionally, secimides showed selective antifungal activity. These findings provide valuable insights into the ecological roles of P. syringae natural products and highlight their potential for biotechnological and therapeutic applications.}, archive = {J_ANGEW}, author = {Shuaibing Zhang and Ying Huang and Raed Nachawati and Philipp Huber and Grit Walther and Lucas Gregor and Ivan Vilotijević and Pierre Stallforth}, doi = {10.1002/anie.202503679}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503679}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pangenome analysis of the plant pathogen pseudomonas syringae reveals unique natural products for niche adaptation}, volume = {64}, year = {2025}, }
• (2025). Through-space 1,4-Ni/H shift: Unlocking migration along coupling partners in olefin borylcarbofunctionalization. ANGEW, 64(25), e202503671. (www)

  @article{ , abstract = {Olefin migratory functionalization is a well-established strategy for the selective installation of functional groups at remote C(sp 3 )−H positions along an alkyl chain. However, prior research has predominantly focused on migration along the alkene component. Herein, we describe a conceptually new migratory coupling strategy for the difunctionalization of alkenes, where migration selectively occurs along the C(sp 2 ) coupling partner rather than the alkene component, facilitated by a through-space 1,4-Ni/H shift. This approach offers a modular three-component strategy for the selective and efficient construction of densely functionalized alkyl boronates from readily accessible chemicals. Moreover, by integrating the 1,2-Ni/H shift with the 1,4-Ni/H shift, this platform has been expanded to achieve a two-fold migration along both the alkene components and the coupling partners, facilitating selective borylative remote C(sp 3 )─H/C(sp 2 )─H cross-coupling.}, archive = {J_ANGEW}, author = {Wenqing Guo and Letian Zi and Jingjie Yang and You Wang and Shaolin Zhu}, doi = {10.1002/anie.202503671}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503671}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Through-space 1,4-Ni/H shift: Unlocking migration along coupling partners in olefin borylcarbofunctionalization}, volume = {64}, year = {2025}, }
• (2025). Acidic CO2 electrolysis with near-ideal selectivity and carbon efficiency enabled by overcoming its inherent trade-off. ANGEW, 64(25), e202503539. (www)

  @article{ , abstract = {Carbon dioxide electroreduction (CO 2 R) in acid tends to be a promising route to avoid CO 2 loss in alkaline and neutral electrolytes; however, high alkali cation concentrations (typically ≥3 M) are required to activate CO 2 and suppress water electroreduction, causing carbonate formation and thus unsatisfied single-pass carbon efficiency (SPCE). Based on theoretical and experimental analyses, we show that an inherent trade-off exists: increasing cation concentrations improves Faradaic efficiency (FE) toward CO 2 R products but comes at the expense of reduced SPCE. We demonstrate a polyimide-modification strategy to overcome this trade-off by taking advantage of the amino groups that can effectively capture protons, creating a local alkaline microenvironment surrounding the electrode surface. In a proof-of-concept experiment, SnO 2 nanoparticles were modified with polyimide and acted as a CO 2 R catalyst, which achieved, simultaneously, near-ideal SPCE of 95.7% and FE of 96% (toward HCOOH) at pH 1.36 with dilute potassium ions down to even 0.1 M. We expect that these findings will accelerate the development of carbon- and electron-efficient acidic CO 2 electrolysis.}, archive = {J_ANGEW}, author = {Li-Ping Chi and Yu-Cai Zhang and Zhuang-Zhuang Niu and Xiao-Long Zhang and Ye-Cheng Li and Tian-Yun Zhang and Shu-Ping Sun and Pu-Gan Lu and Kai-Bin Tang and Min-Rui Gao}, doi = {10.1002/anie.202503539}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503539}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Acidic CO2 electrolysis with near-ideal selectivity and carbon efficiency enabled by overcoming its inherent trade-off}, volume = {64}, year = {2025}, }
• (2025). Reduction of the thermal conductivity of polyurethanes by fluorination: Impact of crystallinity, atomic density, and sound velocity. ANGEW, 64(25), e202503497. (www)

  @article{ , abstract = {The intrinsic thermal conductivity ( ) of polymers ranges between 0.13 W m −1 K −1 in amorphous polyvinyl chloride to 60 W m −1 K −1 in ultrahigh molecular weight polyethylene. Increasing the amorphous content of polymers to further lower is insufficient as this approach reaches a practical limit at approximately 0.15 W m −1 K −1 . Inspired by the low and low speed of sound of fluorinated liquids, we explored whether this behavior in liquids can be extended to polymers. We synthesized seven partially fluorinated (9%–17% atomic fraction F) and ten conventional polyurethanes. Fluorinated polyurethanes exhibit a reduction in up to 50% compared to their nonfluorinated counterparts. Microstructural analysis revealed that the fluorinated polyurethanes exhibited reduced crystallinity and increased molecular spacing. Furthermore, we observed a decreased speed of sound in fluorinated polymers by forced Brillouin scattering via a new analysis method that captures weak signals from highly scattering semicrystalline polymers. The lowest thermal conductivity, 0.13 W m −1 K −1 at room temperature, was observed in polyurethane synthesized from 2,2,3,3,4,4,5,5-octafluoro-1,6-hexanediol (16F) and isophorone diisocyanate (IPDI). Our study provides deeper insights into the relationship between , microstructure, and chemical structure, paving the way to rational design of polymers with thermal conductivity below the lowest limit of conventional amorphous polymers.}, archive = {J_ANGEW}, author = {Jingyi Zhou and Chen Chen and Jinchi Sun and Thomas R. Fielitz and Weijun Zhou and David G. Cahill and Paul V. Braun}, doi = {10.1002/anie.202503497}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503497}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reduction of the thermal conductivity of polyurethanes by fluorination: Impact of crystallinity, atomic density, and sound velocity}, volume = {64}, year = {2025}, }
• (2025). Engineering of transmembrane alkane monooxygenases to improve a key reaction step in the synthesis of polymer precursor tulipalin a. ANGEW, 64(25), e202503464. (www)

  @article{ , abstract = {The α-methylene-γ-butyrolactone tulipalin A, a defense compound found in tulips, can polymerize via addition at the vinyl group or via ring-opening polymerization, making it a highly promising monomer for bio-based polymers. Since the biosynthesis of tulipalin A in plants remains elusive, we propose an alternative pathway for its synthesis starting from the terpenoid intermediate isoprenyl acetate. While fungal unspecific peroxygenases showed a preference for the unwanted epoxidation of the exo- olefin group, bacterial alkane monooxygenases were selective for terminal hydroxylation. By combining protein engineering based on de novo structure prediction of the membrane enzymes with cell engineering, the specific activity was increased 6-fold to 1.83 U g cdw −1 . Oxidation of the formed allylic alcohol by a three-enzyme cascade and subsequent lactonization yielded tulipalin A. Our results demonstrate the feasibility of producing the polymer precursor tulipalin A from terpenoid intermediates and provide a solid foundation for future metabolic engineering endeavors.}, archive = {J_ANGEW}, author = {Andrea Nigl and Veronica Delsoglio and Lucija Sovic and Marina Grgić and Lenny Malihan-Yap and Kamela Myrtollari and Jelena Spasic and Margit Winkler and Gustav Oberdorfer and Andreas Taden and Iva Anić and Robert Kourist}, doi = {10.1002/anie.202503464}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503464}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering of transmembrane alkane monooxygenases to improve a key reaction step in the synthesis of polymer precursor tulipalin a}, volume = {64}, year = {2025}, }
• (2025). Near-zero thermal expansion in coordination polymer cd(1,2,4-Triazole)2(H2PO4)2. ANGEW, 64(25), e202503365. (www)

  @article{ , abstract = {Zero thermal expansion is a rare but desirable physical property for materials. Here, we report an unprecedented near-zero thermal expansion (nZTE) behavior in a two-dimensional (2D) coordination polymer (CP) Cd(1,2,4-triazole) 2 (H 2 PO 4 ) 2 (Cd-Tz) across a broad temperature range of 25 K–400 K. Using multi-temperature high-resolution single-crystal X-ray diffraction, we investigated the structural dynamics of the wine-rack-like framework of Cd-Tz and compared it with that of positive thermal expansion (PTE) CPs Zn-Tz and Mn-Tz with similar framework topology. We show that nZTE in Cd-Tz is a consequence of two monotonic and opposing trends with PTE ( α a , α c ∼22 MK −1 ) in the ac plane and negative thermal expansion (NTE) in the b direction ( α b ∼−47 MK −1 ). A new mechanism for the uniaxial NTE is established based on concerted out-of-plane single atom libration of similarly oriented adjacent triazole rings in the wine-rack motifs. X-ray electron density analysis and modeling of low-temperature vibrational anharmonicity reveals the role of Cd-triazole bonds and hydrogen bonds in promoting the single atom libration. Tuning the metal−ligand bonding strength through minor substitution of Zn/Mn (∼8/12%) in the Cd-Tz lattice results in a prominent shift from nZTE to NTE behavior in the solid solution phases.}, archive = {J_ANGEW}, author = {Sounak Sarkar and Bo Brummerstedt Iversen}, doi = {10.1002/anie.202503365}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503365}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-zero thermal expansion in coordination polymer cd(1,2,4-Triazole)2(H2PO4)2}, volume = {64}, year = {2025}, }
• (2025). Balancing CO2 adsorption and h2 activation on confined ZnOx species for CO2 hydrogenation. ANGEW, 64(25), e202503319. (www)

  @article{ , abstract = {Many oxide catalysts exhibit high selectivity but low conversion in CO 2 hydrogenation due to strong CO 2 adsorption, which often impedes H 2 dissociation and subsequent hydrogenation. Herein, we report that a ZnCr 2 O 4 @ZnO x catalyst featuring monodispersed ZnO x overlayer confined on ZnCr 2 O 4 facilitates CO 2 activation without compromising H 2 activation. This catalyst demonstrates a dual-site mechanism in which ZnCr 2 O 4 surface and/or ZnO x /ZnCr 2 O 4 interface provide sites for CO 2 activation and monodispersed ZnO x promote homolytic H 2 dissociation and formation of stable metal─H species, enabling formate formation through hydrogen spillover to CO 2 adsorption sites for hydrogenation at 303 K. In contrast, H 2 activation on ZnO or ZnCr 2 O 4 suffers from the poisoning effect of strong CO 2 adsorption. Consequently, the ZnCr 2 O 4 @ZnO x catalyst shows 2−8 folds enhancement in CO 2 hydrogenation between 623−773 K than ZnO and maintains 33% conversion and 100% CO selectivity at 723 K over 150 h. The established structure-performance relationship illustrates the critical role of dual-site catalysis and hydrogen spillover in hydrogenation reaction.}, archive = {J_ANGEW}, author = {Haoran Jia and Xiaohui Feng and Xiangze Du and Le Lin and Rentao Mu and Qiang Fu}, doi = {10.1002/anie.202503319}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503319}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Balancing CO2 adsorption and h2 activation on confined ZnOx species for CO2 hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Artificial intelligence-enabled quantitative assessment and intervention for heart inflammation model organoids. ANGEW, 64(25), e202503252. (www)

  @article{ , abstract = {Inflammation plays a crucial role in progression of cardiovascular diseases (CVDs); thus, the discovery of rapid and precise analytical tools to assess inflammation related to CVDs is highly desirable for their diagnosis and therapeutic discovery. However, a straightforward and systematic method for quantitative assessment of inflammation levels in heart organoids has yet to be developed. Herein, we describe the construction of human heart inflammatory organoids with intricate structures and diverse cell lineages and the development of an artificial intelligence (AI)-enabled method for quantitative assessment of inflammation levels in this model. Furthermore, we devised a novel therapeutic strategy to boost endogenous energy molecule production in heart inflammatory organoids to address energy metabolic disorders. This research provides a convenient method for quantitative inflammation evaluation and offers a promising tool for drug discovery.}, archive = {J_ANGEW}, author = {Hongrui Lin and Junjie Cheng and Chuanwei Zhu and Zhiwen Yang and Qi Shen and Yafeng Zou and Yiming Huang and Fengting Lv and Haotian Bai and Shu Wang}, doi = {10.1002/anie.202503252}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial intelligence-enabled quantitative assessment and intervention for heart inflammation model organoids}, volume = {64}, year = {2025}, }
• (2025). Local oxygen vacancy-mediated oxygen exchange for active and durable acidic water oxidation. ANGEW, 64(25), e202503246. (www)

  @article{ , abstract = {Developing an active and durable acidic oxygen evolution reaction (OER) catalyst is vital for implementing a proton exchange membrane water electrolyzer (PEMWE) in sustainable hydrogen production. However, it remains dauntingly challenging to balance high activity and long-term stability under harsh acidic and oxidizing conditions. Herein, through developing the universal rare-earth participated pyrolysis-leaching approach, we customized the active and long lifespan pseudo-amorphous IrO x with locally ordered rutile IrO 2 and unique defect sites (IrO x -3Nd). IrO x -3Nd achieved a low overpotential of 206 mV and long-term durability of 2200 h with a slow degradation rate of 0.009 mV  h −1 at 10 mA cm −2 , and, more importantly, high efficiency in PEMWE (1.68 V at 1 A cm −2 for 1000 h) for practical hydrogen production. Utilizing in situ characterizations and theoretical calculations, we found that lattice oxygen vacancies (O v ) and contracted Ir-O in locally ordered rutile IrO 2 induced the O v -modulated lattice oxygen exchange process, wherein thermodynamically spontaneous occupation of surface hydroxyl groups on O v and effective promotion of O─O coupling and lattice oxygen recovery accounted for enhanced activity and durability. This work underscores the importance of tailor-made local configuration in boosting activity and durability of OER catalyst and different insights into the promotion mechanism.}, archive = {J_ANGEW}, author = {Ning Zhang and Xinyi Liu and Haixia Zhong and Wei Liu and Di Bao and Jianrong Zeng and Depeng Wang and Caini Ma and Xinbo Zhang}, doi = {10.1002/anie.202503246}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202503246}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Local oxygen vacancy-mediated oxygen exchange for active and durable acidic water oxidation}, volume = {64}, year = {2025}, }
• (2025). Dynamic modulation of keto-enol tautomerism in electrolytes for aqueous zinc batteries. ANGEW, 64(25), e202502893. (www)

  @article{ , abstract = {The reversibility of zinc (Zn) anode is subject to adverse reactions. Herein we design a dynamic modulation strategy via enol-keto tautomerism to inhibit the side reactions, thus improving the reversibility of the Zn anode. Density functional theory calculations and experimental results demonstrate the keto form of additives can be adsorbed on the Zn anode, inhibiting dendrite growth, while the enol form can serve as a bidentate ligand to participate in the construction of solvation sheath for Zn 2+ , enhancing the kinetics of Zn 2+ transport, simultaneously suppressing water activity and reducing HER and corrosion. Consequently, the Zn anode with optimal electrolyte additive achieves high reversibility, where Zn||Zn symmetric cells operate over 4000 h at 10 mA cm −2 /10 mAh cm −2 , and Zn||Cu asymmetric cells have a life for 930 h at 10 mA cm −2 /10 mAh cm −2 . Further, this dynamic modulation enables Zn||V 2 O 5 full cells to work over 5000 cycles with a capacity retention of 83% at 5 A g −1 , and the Zn||Br 2 pouch cells deliver a high capacity of ∼180 mAh. This study offers an original perspective on the dynamic regulation of electrolytes for Zn anode.}, archive = {J_ANGEW}, author = {Li Song and Xiaolong Yang and Xinhua Zheng and Mingming Wang and Ruihao Luo and Taoli Jiang and Guili Zhao and Dongyang Shen and Lyuzhou Ye and Wei Chen}, doi = {10.1002/anie.202502893}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic modulation of keto-enol tautomerism in electrolytes for aqueous zinc batteries}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic hydrogenation of quinolines to form 1,2,3,4-tetrahdyroquinolines using water as the hydrogen atom donor. ANGEW, 64(25), e202502864. (www)

  @article{ , abstract = {The design of a sequential process combining hydrogenation and a subsequent stereomutation is an attractive strategy for the stereoselective reduction of cyclic disubstituted π–systems to access the thermodynamically more stable trans isomer, which would be the minor compound considering a kinetically controlled cis hydrogenation process. Herein, we demonstrate stereoselective photocatalytic phosphine-mediated quinoline reductions with water as the hydrogen atom source under mild conditions to afford the corresponding 1,2,3,4-tetrahydroquinolines with complete selectivity towards reduction of the heteroaromatic part. The method shows broad functional group tolerance and provides access to trans -2,3-disubstituted tetrahydroquinolines with moderate to excellent diastereoselectivity. These trans isomers are not readily obtained using established methods, as transition-metal-catalyzed regioselective quinoline hydrogenations provide the corresponding cis -2,3-disubstituted isomers with high selectivity. Mechanistic studies reveal that the hydrogenation of the 2,3-disubstituted quinolines proceeds through a cascade process comprising an initial cis selective photocatalytic hydrogenation of the heteroarene core of the quinoline, followed by a trans selective photoisomerization.}, archive = {J_ANGEW}, author = {Jingjing Zhang and Nico Spreckelmeyer and Jessika Lammert and Maxim-Aleksa Wiethoff and Matthew James Milner and Christian Mück-Lichtenfeld and Armido Studer}, doi = {10.1002/anie.202502864}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic hydrogenation of quinolines to form 1,2,3,4-tetrahdyroquinolines using water as the hydrogen atom donor}, volume = {64}, year = {2025}, }
• (2025). Stabilizing lattice oxygen to enable durable MnO2 electrocatalyst for simultaneous acidic hydrogen production and biomass valorization. ANGEW, 64(25), e202502847. (www)

  @article{ , abstract = {Understanding and steering the stability of earth-abundant electrocatalysts in acidic medium is essential for proton exchange membrane (PEM) water electrolyzer. Manganese oxide (MnO 2 ) is one of the promising candidates for acidic oxygen evolution reaction (OER), but it still suffers from the overoxidation and the underlying mechanism remains elusive. Here, we observed that lattice oxygen was involved in the OER process on γ-MnO 2 via Mars-van-Krevelen mechanism. Combined with theoretical calculation, we revealed that the release of lattice oxygen lowers the energy barrier of Mn dissolution and compromises the electrode durability. Based on this finding, we propose a strategy to efficiently stabilize lattice oxygen and suppress Mn overoxidation by replacing OER with glucose oxidation to formic acid, which follows a Langmuir–Hinshelwood mechanism. As a result, the durability of γ-MnO 2 was enhanced by 1100 times, enabling long stability up to 960 hours. Moreover, we demonstrated a production rate of 487.1 mmol h −1 for formic acid and 16.7 L h −1 for H 2 at 40 A in a PEM electrolyzer, providing a sustainable and scalable route for converting water and biomass into valuable chemicals and fuels.}, archive = {J_ANGEW}, author = {Yingjie Song and Jialong Qian and Shengnan Li and Ziling Zhao and Hongwu Chen and Kang Zou and Zishan Han and Zhenhua Li and Hao Li and Hua Zhou and Mingfei Shao}, doi = {10.1002/anie.202502847}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilizing lattice oxygen to enable durable MnO2 electrocatalyst for simultaneous acidic hydrogen production and biomass valorization}, volume = {64}, year = {2025}, }
• (2025). Core-shell hyperbranched polymers via catalytic ring-opening metathesis polymerization. ANGEW, 64(25), e202502773. (www)

  @article{ , abstract = {This work explores the synthesis, characterization, and applications of hyperbranched polymers (HBP) using a divergent ring-opening metathesis polymerization (ROMP) approach. An ABB′-type hyperbranching monomer, formed by covalently linking a traditional ROMP monomer to a chain transfer agent, was diluted with a linear comonomer to produce branched polymers with controlled molar mass and dispersity. Dynamic light scattering (DLS) and X-ray scattering confirmed their globular shape in solution. Additionally, we functionalized HBPs to create core-shell materials capable of encapsulating organic dyes efficiently. The study also highlights their role in sustainable polymer design, demonstrating degradation under mild acidic conditions. Core-shell particles synthesized via this approach enabled efficient capture and rapid, on-demand release of guest molecules, emphasizing their potential in drug delivery and advanced materials science.}, archive = {J_ANGEW}, author = {Indradip Mandal and Ijaj Ahmed and Bettina Tran and Stefan Salentinig and Georges J. M. Formon and Christoph Weder and Andreas F. M. Kilbinger}, doi = {10.1002/anie.202502773}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502773}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Core-shell hyperbranched polymers via catalytic ring-opening metathesis polymerization}, volume = {64}, year = {2025}, }
• (2025). Coupling of CuO@NiBiOx catalyzed glycerol oxidation to carbon dioxide reduction reaction for enhanced energy efficiency. ANGEW, 64(25), e202502617. (www)

  @article{ , abstract = {Glycerol electrooxidation reaction (GEOR) is a promising alternative to the oxygen evolution reaction (OER) in electrolyzers, overcoming the inherent challenges of high energy demand and low-value output of water oxidation. Here, we designed a non-noble metal-based electrocatalyst (CuO@NiBiO x , CNBO) for selective and efficient GEOR. The CNBO catalyst demonstrated high selectivity and achieved nearly 100% GEOR Faradaic efficiency (FE), 80%–90% of which is conveyed into formic acid (FA). Bismuth incorporation modified the structure of the mixed oxide, increasing the surface concentration of Ni(III) species and enhancing the GEOR activity. In situ studies confirmed the formation of NiOOH, which is identified as the active site for GEOR and suggests an indirect GEOR mechanism. This study demonstrates the potential of GEOR to replace OER in Carbon dioxide reduction reaction (CO 2 RR) electrolyzers. Depending on the selected CO 2 RR catalyst (Ag or Sn), we could obtain either an easy-to-separate mixture of high-added value products (CO and FA) or a single product (FA) with FE FA > 85% at both electrodes. Moreover, we demonstrate that replacing OER with GEOR in a CO 2 RR-electrolyzer can save up to 25% of the electrolysis energy input, while the co-production of FA at both electrodes halves the energy per mole required for its electrosynthesis.}, archive = {J_ANGEW}, author = {Thi-Hong-Hanh Le and Yong Zuo and Manjunath Chatti and Martina Rizzo and Andrea Griesi and Abinaya Annamalai and Simone Lauciello and Luca Leoncino and Mirko Prato and Silvia Dante and Ilka Kriegel and Giorgio Divitini and Michele Ferri and Liberato Manna}, doi = {10.1002/anie.202502617}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502617}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coupling of CuO@NiBiOx catalyzed glycerol oxidation to carbon dioxide reduction reaction for enhanced energy efficiency}, volume = {64}, year = {2025}, }
• (2025). Water serving as cocatalyst for the highly efficient homogeneously catalyzed conversion of N2O/H2 mixtures with optimized rhodium NHC complexes. ANGEW, 64(25), e202502616. (www)

  @article{ , abstract = {Nitrous oxide (N 2 O) is a valuable oxygen/nitrogen transfer reagent but reactions with N 2 O are challenging due to its inertness. Consequently, it accumulates in the atmosphere, and because it is both an ozone-depleting reagent and potent green-house gas, effective mitigation methods become important. This study presents rhodium(I) amido bis(olefin) N -heterocyclic carbene complexes [Rh(trop 2 N)(NHC)] as robust homogeneous catalysts for the direct hydrogenation of N 2 O. Kinetic experiments and DFT calculations show that increasing π -acidity of the NHC and the presence of water significantly enhance the catalytic efficiency. The rhodium-amido bond facilitates cooperative H 2 -cleavage and oxygen atom transfer from N 2 O. The catalyst is regenerated with the loss of water from the hydroxide intermediate [Rh(OH)(trop 2 NH)(NHC)], which forms a dimeric complex with a central bridging hydrated hydroxide ligand [H 3 O 2 ] − . Water facilitates dinitrogen (N 2 ) loss from an intermediate containing an oxy-diazene ligand [H─N═N─O] − . The optimized catalyst achieves a TON > 230 000 and TOF > 1300 h −1 .}, archive = {J_ANGEW}, author = {Sven Thomas Nappen and Juan José Gamboa-Carballo and Esther Tschanen and Federica Ricatto and Michael Dieter Wörle and Arne Thomas and Monica Trincado and Hansjörg Grützmacher}, doi = {10.1002/anie.202502616}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Water serving as cocatalyst for the highly efficient homogeneously catalyzed conversion of N2O/H2 mixtures with optimized rhodium NHC complexes}, volume = {64}, year = {2025}, }
• (2025). Neighboring carbon defects enhanced molecular oxygen activation of cobalt single atom catalysts toward efficient aerobic alcohols oxidation. ANGEW, 64(25), e202502430. (www)

  @article{ , abstract = {The effective adsorption and activation of molecular oxygen (O 2 ) is crucial for aerobic alcohol oxidation; however, flexibly modulating the electronic structure of catalysts to improve the capability remains challenging. Herein, the concentration of carbon defects surrounding the nitrogen-coordinated cobalt (Co) single atoms on candle soot is controlled just through adjusting the amount of polyethyleneimine which chemically decorates the surface of candle soot to anchor Co ions. The concentration increase of carbon defects boosts the aerobic alcohol oxidation over the Co single-atom catalyst as well as ruthenium single-atom catalyst. Moreover, a series of alcohols, including those with sensitive groups, reach an outstanding yield. Significantly, the calculations and experiments verify that the carbon defects lead to the rearrangement of d-orbitals of Co atom and an elevation in the spin states of d yz and orbitals. Furthermore, compared with low-spin Co atom, the stronger electron-transfer interaction between high-spin Co atom and O 2 enhances the adsorption and activation of O 2 and the generation of more superoxide radicals to promote alcohol oxidation. Our findings provide a new way for developing advanced single-atom catalysts for sustainable aerobic alcohol oxidation via manipulating the spin configurations of single atoms.}, archive = {J_ANGEW}, author = {Xiaoli Luo and Weiqin Wei and Yingzhuang Xu and Di Liu and Zhen Wei and Junxiao Liu and Zhipeng Li and Liang Wang and Shuxin Ouyang and Hong Yuan and Zhen Liu and Tierui Zhang}, doi = {10.1002/anie.202502430}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502430}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Neighboring carbon defects enhanced molecular oxygen activation of cobalt single atom catalysts toward efficient aerobic alcohols oxidation}, volume = {64}, year = {2025}, }
• (2025). Remote silyl groups enhance hydrolytic stability and photocleavage efficiency in carbamates for protein release. ANGEW, 64(25), e202502376. (www)

  @article{ , abstract = {Photocleavable molecules are valuable tools for biological studies, enabling spatiotemporal activation of molecular functions within cellular environments. In particular, coumarin-based photolytic molecules are useful because of their ability to flexibly tune the wavelength of photostimulation through their structural modifications. Ideal photocleavable molecular tools require hydrolytic stability and selective susceptibility to photo stimuli. However, conventional coumarin-based molecules have not simultaneously achieved both highly efficient photocleavage and hydrolysis resistance. Herein, we proposed a novel molecular design concept that introduces a silyl group into coumarin-based molecules at a position remote from the photolabile bond, creating an ideal photocleavable molecule for chemical biology tools. The established orbital effect of the remotely introduced silyl group improves the photolysis efficiency of coumarin-based molecules, while its bulkiness substantially enhances their hydrolytic stability in aqueous environments and under enzymatic conditions. Furthermore, this improvement in molecular functionality contributes to the development of high-performance protein-release biomaterials.}, archive = {J_ANGEW}, author = {Masahiko Yoshimura and Ryuto Sasayama and Takashi Kajiwara and Chihiro Mori and Yusuke Nakasone and Tomoko Inose}, doi = {10.1002/anie.202502376}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502376}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote silyl groups enhance hydrolytic stability and photocleavage efficiency in carbamates for protein release}, volume = {64}, year = {2025}, }
• (2025). A ketone-accepting Pictet–Spenglerase for the asymmetric construction of 1,1-disubstituted tetrahydro-ß-carboline alkaloids. ANGEW, 64(25), e202502367. (www)

  @article{ , abstract = {In light of the ubiquity of 1,1′-disubstituted tetrahydro-ß-carboline (THBC) motif in alkaloid natural products, developing asymmetric methodology for its preparation is highly valuable. Despite the immense progress toward achieving stereoselective Pictet–Spengler reaction with aldehydes, the analogous reaction with ketones is still underdeveloped. Exploiting KslB, a Pictet–Spenglerase from the biosynthesis of kitasetaline, we develop a general, diastereoselective, and protecting-group free method for the construction of densely functionalized THBCs with α-quaternary center by coupling tryptophan derivatives and α-keto acids. We determine the stereochemistry of kitasetalic acid, KslB's physiological product and a key biosynthetic intermediate toward kitasetaline, and established that KslB's selectivity is opposite to what is achieved chemically. Our investigations of KslB show its high activity (total turnover number >438000), substrate promiscuity, and tolerance for high substrate concentrations (0.1 M). Additionally, a TrpB-KslB cascade enables the construction of complex tricyclic products from simple indoles in one-pot. X-ray structural characterization of KslB sheds light on potential active site interactions to account for its stereoselectivity and ability to accept ketone substrates.}, archive = {J_ANGEW}, author = {Ruiying Jiang and Nour Wasfy and Takahiro Mori and Megan Hoang and Ikuro Abe and Hans Renata}, doi = {10.1002/anie.202502367}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502367}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A ketone-accepting Pictet–Spenglerase for the asymmetric construction of 1,1-disubstituted tetrahydro-ß-carboline alkaloids}, volume = {64}, year = {2025}, }
• (2025). Fluorogenic interacting protein stabilization for orthogonal RNA imaging. ANGEW, 64(25), e202502350. (www)

  @article{ , abstract = {Live imaging of RNAs is crucial to interrogate their cellular functions, but genetically encodable RNA imaging systems compatible with multiplexed and in vivo applications remain a persistent challenge. We propose a new concept of fluorogenic interacting protein stabilization (FLIPS) that enables the engineering of RNA-binding proteins (RBPs) such as MCP, L7Ae, Cse3, and LIN28A into orthogonal RNA-stabilized fluorogenic proteins for multiplexed RNA imaging. The FLIPS system comprises elaborate engineering of the fluorescence protein-fused RBPs through circular permutation and incorporation with a C-terminal poly(arginine)-appended degron. We show that the RNA motifs bind and stabilize the cognate-engineered RBPs with a proximity-mediated synergistic effect from the poly(arginine) region due to enhanced electrostatic interactions. The FLIPS design affords a generally applicable strategy for different RNA motifs and RBPs, enabling orthogonal and multi-color fluorescence-activated RNA imaging. The design is demonstrated for multicolor and orthogonal imaging of RNAs, single-molecule RNA imaging and tracking, simultaneous imaging of two RNAs in nuclear condensates, and biplexed tracking of RNA translocation into cytosolic condensates. The versatility of our system highlights its potential for interrogating RNA biology and developing RNA-based imaging tools.}, archive = {J_ANGEW}, author = {Wen-Jing Zhou and Mei-Yan Wu and Xin-Juan Shao and Li-Juan Tang and Fenglin Wang and Jian-Hui Jiang}, doi = {10.1002/anie.202502350}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorogenic interacting protein stabilization for orthogonal RNA imaging}, volume = {64}, year = {2025}, }
• (2025). Solar-driven massive production of dimerized imine in aqueous phase via an atomically engineered photocatalyst. ANGEW, 64(25), e202502202. (www)

  @article{ , abstract = {Photocatalytic selective oxidation of organics coupled with green H 2 evolution represents a promising avenue for the sustainable production of value-added chemicals, but suffers from sluggish charge separation and difficult selectivity manipulation. In particular, the Schottky barrier-induced adsorption of expected organic products at reduction sites tends to trigger the hydrogenation side reaction, which is more pronounced in the ideal aqueous environment due to distinct polarity. Here, we report a precise cocatalyst strategy on ZnIn 2 S 4 (ZIS) photocatalyst at the atomic level to eliminate the Schottky barrier between ZIS and cocatalyst, thus achieving exceptional activity (565 µmol h −1 ) and selectivity (99%) for photocatalytic dimerized imine production in aqueous media, which is five times more effective than ZIS loaded with Pt nanoparticles. The excellent performance is achieved by effectively attenuating the accumulation of photogenerated holes near the Pt sites and then suppressing the unwanted hydrogenation side reaction. We further demonstrate that our system can be directly scaled up to 0.5 m 2 for scalable outdoor experiment and achieve solar-driven production of benzylimine with 125 mL yield and 97 wt% purity for two weeks under solar irradiation. This study presents an interfacial atomical design strategy for photocatalysts to efficiently produce high-value imine coupled with H 2 under mild and green conditions.}, archive = {J_ANGEW}, author = {Nengcong Yang and Zixi Yin and Zhian Chen and Chao Gao and Zhuwei Cao and Yi Zheng and Zhenhua Pan and Haiqun Cao and Sheng Ye and Yujie Xiong}, doi = {10.1002/anie.202502202}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502202}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solar-driven massive production of dimerized imine in aqueous phase via an atomically engineered photocatalyst}, volume = {64}, year = {2025}, }
• (2025). The flexibility of Tetra(N-heterocyclic carbene) ligands controls the nuclearity and geometry of polynuclear MI‒NHC assemblies. ANGEW, 64(25), e202502081. (www)

  @article{ , abstract = {A series of tetrakisimidazolium salts bearing two di(phenylimidazolium)amine groups linked by differently substituted anthracenes has been prepared. These are H 4 - 1a (PF 6 ) 4 (anthracene bridge), H 4 - 1b (PF 6 ) 4 (phenyl-anthracene-phenyl bridge), H 4 - 1c (PF 6 ) 4 (anthracene-phenyl bridge), and H 4 - 1d (PF 6 ) 4 (anthracene-phenyl-anthracene bridge). X-ray crystallography showed that those ligand precursors having the di(phenylimidazolium)amine connected directly to the anthracene experience restricted rotation about the N─C anthracene bond. Depending on their flexibility, the reaction of the tetrakisimidazolium salts with Ag 2 O followed by transmetalation with [AuCl(THT)] yielded octanuclear ([Au 8 ( 1a ) 4 ](PF 6 ) 8 ), tetranuclear ([Au 4 ( 1b ) 2 ](PF 6 ) 4 ), hexanuclear ([Au 6 ( 1c ) 3 ](PF 6 ) 6 ), or octanuclear ([Au 8 ( 1d ) 4 ](PF 6 ) 8 ) assemblies, demonstrating the direct bonding strategy can be employed for the selective synthesis of polynuclear poly-NHC (NHC = N-heterocyclic carbene) metallosupramolecular assemblies.}, archive = {J_ANGEW}, author = {Guang-Feng Jin and Fang Wang and F. Ekkehardt Hahn and Ying-Feng Han}, doi = {10.1002/anie.202502081}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502081}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The flexibility of Tetra(N-heterocyclic carbene) ligands controls the nuclearity and geometry of polynuclear MI‒NHC assemblies}, volume = {64}, year = {2025}, }
• (2025). Spider eye development editing and silk fiber engineering using CRISPR-cas. ANGEW, 64(25), e202502068. (www)

  @article{ , abstract = {CRISPR-Cas9 gene editing represents an effective and precise technology to induce mutations in the genome, and it has been applied to a wide range of organisms for diverse purposes. However, CRISPR-based gene editing in spiders has not been reported to date. In this study, we demonstrate CRISPR-mediated microinjection in parental spiders leading to both knock-out (KO) and knock-in (KI) mutations within the spider's offspring. The KO of the gene sine oculis causes total eye loss, confirming the role of the gene in the development of all spider eyes. The KI of a monomeric red fluorescent protein (mRFP-KI) within a spider silk gene encoding one compound of the major ampullate silk of the spider Parasteatoda tepidariorum yields red fluorescent silk fibers. This finding demonstrates the feasibility of functionalizing silk proteins in spiders using CRISPR-based gene editing without influencing silk assembly. Our study expands the application of CRISPR to spiders and provides insights in the fields of developmental genetics as well as material sciences.}, archive = {J_ANGEW}, author = {Edgardo Santiago-Rivera and Thomas Scheibel}, doi = {10.1002/anie.202502068}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502068}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spider eye development editing and silk fiber engineering using CRISPR-cas}, volume = {64}, year = {2025}, }
• (2025). Building ultrathin MOL/MOL S-scheme heterostructures toward boosted photocatalytic charge kinetics for efficient h2 evolution. ANGEW, 64(25), e202502009. (www)

  @article{ , abstract = {Photocatalytic efficiencies highly depend on the kinetic behaviors of photogenerated electrons in catalysts. Herein, based on the promising metal-organic frameworks (MOFs), we design and build an advantageous architecture of ultrathin MOF-layer (metal-organic layers [MOL]) heterojunctions by a facile pH-adjusted electrostatic assembling of pre-exfoliated porphyrinic and pyrene-based MOLs. Such an architecture constitutes an S-scheme junction to drive interfacial charge separation, features ultrathin structures to shorten charge transfer distances, and maximizes accessible metal sites to facilitate terminal charge reaction, thoroughly promoting the charge kinetics in materials. The resulting MOL/MOL composites perform a significantly enhanced catalytic activity for visible-light-driven H 2 evolution, 8.5 and 106 times that of individual MOLs. Further fine-tuning into more reactive metal nodes achieves an optimal H 2 production (2027 µmol h −1 g −1 ) with a high apparent quantum yield of 2.75% without additional cocatalysts, ranking among state-of-the-art activities from all-MOF photocatalysts. This work demonstrates an accessible and universal methodology to realize a superior ultrathin MOL/MOL heterojunction architecture toward accelerated charge kinetics, providing valuable insights for the development of efficient photocatalyst systems for solar-to-chemical energy conversions.}, archive = {J_ANGEW}, author = {Qing-Ping Huang and Chao Yang and Qi Yin and An-An Zhang and Hai-Xiong Liu and Lan Li and Mei-Mei Liu and Zhi-Bin Fang and Tian-Fu Liu}, doi = {10.1002/anie.202502009}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202502009}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Building ultrathin MOL/MOL S-scheme heterostructures toward boosted photocatalytic charge kinetics for efficient h2 evolution}, volume = {64}, year = {2025}, }
• (2025). Indole-quinoline transmutation enabled by a formal rhodium carbynoid. ANGEW, 64(25), e202501966. (www)

  @article{ , abstract = {Skeleton editing is an emerging and powerful tool in organic chemistry because it can simplify synthetic procedures towards complex molecules. Herein, we present an approach for indole-quinoline transmutation through rhodium-catalyzed single-carbon insertion into the C2( sp 2 )─C3( sp 2 ) bond of an indole with an α-diazotrifluoroethyl sulfonium salt that we developed. This protocol involves a formal trifluoromethyl rhodium carbynoid (CF 3 C + = Rh) resembling a trifluoromethyl cationic carbyne (CF 3 C + :), allowing facile access to an array of quinolines in moderate to high yields. Potential applications in the late-stage skeletal editing of pharmaceutical and natural product derivatives, preparation of adapalene analogs, scaled-up synthesis, and transformations of products are highlighted. Finally, a computational study was conducted to support the envisioned mechanism.}, archive = {J_ANGEW}, author = {Lu-Jie Liu and Meng-Yang Tian and Zhi-Yu Lang and Yong-Li Wang and Chun-Yang He and Yong-Zheng Chen and Wen-Yong Han}, doi = {10.1002/anie.202501966}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501966}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Indole-quinoline transmutation enabled by a formal rhodium carbynoid}, volume = {64}, year = {2025}, }
• (2025). Characterizing disorders within cathode materials of lithium-ion batteries. ANGEW, 64(25), e202501958. (www)

  @article{ , abstract = {The demand for developing high-energy density cathode materials has been increasing. The energy densities of cathode materials have been improved by adapting structural deviation from the ideal fully ordered α-NaFeO 2 type, but that led to limitations in terms of structural stability and safety. Although disorders in cathode materials are closely related to their electrochemical properties, unfortunately, characterizing the disorder itself in cathode materials has been challenging due to its complex parasitic reaction and strong correlation with other disorders occurring during charge/discharge. In this review, we categorize various disorders by their scales of ordering from short-range to long-range. We addressed the principles of various characterization tools to figure out how they can help to identify the structural disorder in cathode materials. Specifically, we focused on the underlying principles of each characterization technique to correlate different disorder-driven phenomena through several case studies. It underscores the substantial importance of disorder-property relationships and the corresponding characterization methods, which can provide novel research strategies for developing high-energy density cathode materials with decent structural stability.}, archive = {J_ANGEW}, author = {Hakwoo Lee and Jihyun Kim and Suwon Lee and Maxim Avdeev and Wanli Yang and Yong-Mook Kang}, doi = {10.1002/anie.202501958}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501958}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Characterizing disorders within cathode materials of lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Plasmonic-hydrogel hybrid biomaterials via in situ seeded growth. ANGEW, 64(25), e202501854. (www)

  @article{ , abstract = {The combination of hydrogels and functional plasmonic metal nanoparticles affords the development of unique hybrid systems, such as actuators, biosensors, and drug delivery systems, among others. Being typically prepared in colloidal suspension, incorporating shape-controlled plasmonic nanoparticles on polymer substrates typically requires lengthy processes involving synthesis, washing, and self-assembly. We report an alternative, robust in situ seed-mediated growth method whereby either isotropic or anisotropic gold and silver nanoparticles can be prepared directly on gelatin-based hydrogels, taking advantage of the polymer's native chemical functionalities. In-depth characterization of gold precursor–polymer interactions enabled the rational growth of branched gold nanoparticles on biocompatible hydrogels with different physicochemical properties. In situ seeded growth circumvents traditional limitations imposed by the need for colloidal stability, thereby enabling gold nanoparticle synthesis under surfactant-free conditions and in high ionic strength solutions, thus enhancing their suitability for applications involving live cells. This method can be expanded to create libraries of hybrid plasmonic materials with potential impact in the fabrication of functional 3D cell culture substrates, as well as biological and chemical sensors.}, archive = {J_ANGEW}, author = {Gail A. Vinnacombe-Willson and Manuel Núñez-Martínez and Ada Herrero-Ruiz and Francisco Bevilacqua and Raquel Pazos and Lara Troncoso-Afonso and Marta Gallego-González and Leonardo Scarabelli and Luis M. Liz-Marzán}, doi = {10.1002/anie.202501854}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501854}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plasmonic-hydrogel hybrid biomaterials via in situ seeded growth}, volume = {64}, year = {2025}, }
• (2025). Continuous flow synthesis of nitrofuran pharmaceuticals using acetyl nitrate. ANGEW, 64(25), e202501660. (www)

  @article{ , abstract = {Nitrofurfural is a key building block for the synthesis of antimicrobial nitrofurans as active pharmaceutical ingredients. Its synthesis involves the nitration of furfural, a substrate derived from biobased resources. However, furfural has a delicate heteroaromatic backbone. Typical nitrations involve harsh reaction conditions, which often compromise this structure, resulting in poor reproducibility and low yields. Although acetyl nitrate, a mild nitrating agent, is suitable for this task, major deterrents remain. First, its conventional preparation method involves conditions that are not compatible with furfural. Second, significant safety concerns are associated with the unstable and explosive nature of acetyl nitrate. These critical issues are addressed herein. A safe and robust continuous flow platform featuring in situ generation of acetyl nitrate for the nitration of furfural to nitrofurfural is reported. The high level of integration and automation enables remote process operation by a single operator. Key furfural-based pharmaceutical intermediates were synthesized with favorable metrics and high reproducibility. The efficiency of this flow platform is demonstrated using a selection of best-selling nitrofuran pharmaceuticals (nifuroxazide, nifurtimox, nitrofurantoin, and nitrofural), which were obtained with excellent isolated yields in under five minutes.}, archive = {J_ANGEW}, author = {Hubert Hellwig and Loïc Bovy and Kristof Van Hecke and Cornelis P. Vlaar and Rodolfo J. Romañach and Md. Noor-E-Alam and Allan S. Myerson and Torsten Stelzer and Jean-Christophe M. Monbaliu}, doi = {10.1002/anie.202501660}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501660}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Continuous flow synthesis of nitrofuran pharmaceuticals using acetyl nitrate}, volume = {64}, year = {2025}, }
• (2025). Vinyl-functionalized linear alkyl chains in nonfullerene acceptors enable 19.2% efficiency and stable as-cast organic solar cells. ANGEW, 64(25), e202501592. (www)

  @article{ , abstract = {Developing efficient and stable as-cast organic solar cells (OSCs) is imperative for alleviating costs and complexity for large-scale commercial applications. Nevertheless, achieving the desired double-fibril morphology of active layer through single-step processing is challenging. Herein, two nonfullerene acceptors, namely BTP-N6 and BTP-V6, are designed and synthesized to construct as-cast OSCs by introducing linear alkyl chains adjacent to the pyrrole moiety. The reduction of steric hindrance attributable to linear chains engenders diminished dihedral angles of molecular skeletons, thereby promoting compact and face-on oriented molecular stacking. Moreover, BTP-V6 featuring vinyl-functionalized linear chains manifests additional interaction sites with neighboring molecules to instigate enhanced π–π stacking during rapid film-formation process and engenders the formation of a refined double-fibril network morphology, which facilitates exciton dissociation, bolsters charge carrier transport, and suppresses recombination loss. Consequently, the D18:BTP-V6 based device attained a record-shattering efficiency of 19.2% with a high fill factor (FF) of 80.7%, and also demonstrated robust thermal and shelf stability. Moreover, the meticulously optimized layer-by-layer (LBL) structured devices achieved an excellent efficiency up to 20.1%. This study introduces a viable strategy for alkyl chain modification to fabricate efficient and stable as-cast devices, with the anticipation of expediting the progression toward widespread commercialization of OSCs.}, archive = {J_ANGEW}, author = {Chenyu Han and Bo Cheng and Zhen Fu and Hao Wang and Shengqi Ji and Jingnan Wu and Sixuan Cheng and Xinxin Xia and Hang Yin and Xiaoyan Du and Ergang Wang and Xia Guo and Xiaotao Hao and Yongfang Li and Maojie Zhang}, doi = {10.1002/anie.202501592}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501592}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vinyl-functionalized linear alkyl chains in nonfullerene acceptors enable 19.2% efficiency and stable as-cast organic solar cells}, volume = {64}, year = {2025}, }
• (2025). α-amination of 1,3-dicarbonyl compounds and analogous reactive enolate-precursors using ammonia under oxidative conditions. ANGEW, 64(25), e202501586. (www)

  @article{ , abstract = {We, herein, introduce a method for the direct α-amination of different carbonyl compounds by employing aqueous ammonia as the N -source. Upon using NH 3 in combination with hypochlorites as simple oxidants under phase-transfer catalytic conditions it is possible to carry out the direct α-amination of reactive enolate-precursors such as cyclic β-ketoesters, oxindoles, as well as malonitriles and malonates with good to excellent yields, while simple ketone precursors being out of the scope thus far. Furthermore, a first proof-of-concept for an asymmetric variant by employing a chiral quaternary ammonium salt is reported.}, archive = {J_ANGEW}, author = {Christopher Mairhofer and Katharina Röser and Gabriel Burel and Sarah Merzinger and Jean-François Brière and Roland Obermüller and Mario Waser}, doi = {10.1002/anie.202501586}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501586}, shortjournal = {Angew. Chem. Int. Edit.}, title = {α-amination of 1,3-dicarbonyl compounds and analogous reactive enolate-precursors using ammonia under oxidative conditions}, volume = {64}, year = {2025}, }
• (2025). An enzymatic platform for asymmetric synthesis of si-stereogenic silanols. ANGEW, 64(25), e202501524. (www)

  @article{ , abstract = {Chiral silanols are important synthetic targets and have garnered increasing attention in the materials and pharmaceutical industries over recent decades. A promising approach for their efficient synthesis is asymmetric silane oxidation. While chemists have developed several transition-metal-catalyzed systems for asymmetric hydrolytic oxidation of silanes, no biocatalytic methods have been available for enantioselective synthesis of Si -stereogenic compounds, including chiral silanols. Here, we present an enzymatic platform for the asymmetric aerobic mono-oxidation of dihydrosilanes using an engineered P450 BM3 enzyme. Through six iterative rounds of directed evolution, we identified the optimal evolved variant, ASOx-6, which exhibits a 54-fold improvement in k cat / K M compared with the wild-type enzyme. Moreover, a variety of aryl–alkyl substituted dihydrosilanes are accepted by ASOx-6, including those bearing heteroaromatic rings. Finally, mechanistic insights obtained from kinetic isotope experiments and computational studies further elucidate the nature of this biocatalytic transformation.}, archive = {J_ANGEW}, author = {Shuang-Yu Dai and Xiahe Chen and Yun-Fang Yang and Zhen Liu}, doi = {10.1002/anie.202501524}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An enzymatic platform for asymmetric synthesis of si-stereogenic silanols}, volume = {64}, year = {2025}, }
• (2025). Synergistic co-recycling: Selective oxidation of polyethylene to dicarboxylic acids over spent LiCoO2 cathodes. ANGEW, 64(25), e202501509. (www)

  @article{ , abstract = {The escalating production of lithium-ion batteries and plastics poses critical challenges to environmental integrity and resource sustainability. Here, we report a synergistic co-recycling strategy for spent lithium cobalt oxide (LCO) cathodes and waste polyethylene (PE), leveraging the catalytic properties of LCO to oxidize PE into high-value dicarboxylic acids. Through a combination of density functional theory calculations, electron spin resonance, and in situ infrared spectroscopy, we reveal that lithium-deficient LCO undergoes a spin-state transition of Co 3+ to a high-spin state, facilitating the activation of oxygen and the generation of singlet oxygen. This reactive oxygen species drives the selective oxidation of PE via hydrogen atom transfer, achieving dicarboxylic acid yields of up to 77.5 wt%, markedly exceeding previous benchmarks. Validation with real-world plastic waste and spent batteries underscores the feasibility of this approach, presenting a sustainable paradigm-shift solution for the efficient management of lithium-ion batteries and plastic waste in a circular economy.}, archive = {J_ANGEW}, author = {Shengming Li and Qianyue Feng and Qingye Li and Yeping Xie and Panpan Xu and Zhao Wang and Qiming Sun and Muhan Cao and Qiao Zhang and Jinxing Chen}, doi = {10.1002/anie.202501509}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501509}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic co-recycling: Selective oxidation of polyethylene to dicarboxylic acids over spent LiCoO2 cathodes}, volume = {64}, year = {2025}, }
• (2025). Low-redox-barrier two-electron p-type phenoselenazine cathode for superior zinc-organic batteries. ANGEW, 64(25), e202501278. (www)

  @article{ , abstract = {Organic p-type cathode materials with high redox potentials and fast kinetics have captured widespread attention in propelling Zn-organic batteries (ZOBs). However, their anion-accessible capacity is insufficient due to single electron reaction and/or high energy barrier of each redox-active unit. Here, we design two-electron-donating p-type organic chalcogen small molecules (phenoxazine (PO), phenothiazine (PS), and phenoselenazine (PSe)) with tuned charge distributions and electron transfer behaviors as cathode materials for ZOBs. With the decrease of chalcogenide electronegativity (O > S > Se), PSe liberates the strongest coordination activity, efficient electron delocalization, and charge storage kinetics with an ultralow redox activation energy (0.23 vs. 0.34 eV of PS and 0.41 eV of PO), which contributes to high dual-electron utilization of phenazine motifs of 99.2% (vs. 68.8% of PS and 52.7% of PO). Consequently, Zn||PSe battery delivers the highest capacity storage (227 mAh g −1 ) and energy density (273 Wh kg −1 ) among the reported p-type cells, along with long life (10 000 cycles). A two-electron redox mechanism is unlocked at amine/selenium sites of PSe, accompanied by reversible uptake of two CF 3 SO 3 − anions. This study highlights the considerable potential of low-energy-barrier multielectron design for high-performance organic cathodes toward advanced ZOBs.}, archive = {J_ANGEW}, author = {Ting Shi and Ziyang Song and Chengmin Hu and Qi Huang and Yaokang Lv and Ling Miao and Lihua Gan and Dazhang Zhu and Mingxian Liu}, doi = {10.1002/anie.202501278}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501278}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-redox-barrier two-electron p-type phenoselenazine cathode for superior zinc-organic batteries}, volume = {64}, year = {2025}, }
• (2025). Achieving a highly reversible four-electron redox of S/Cu2S for aqueous Zn/S─Cu battery. ANGEW, 64(25), e202501205. (www)

  @article{ , abstract = {The combination of sulfur (S) cathode with Cu 2+ /Cu + redox carriers has been considered as a promising cathode for the next-generation aqueous energy storage device due to the high specific capacity (two-step four-electron conversion), intrinsic safety, and low cost. Nevertheless, the unsatisfactory cycling stability of a sulfur–copper (S–Cu) cathode hinders its practical application. Herein, the two-step four-electron conversions are first decoupled in our study, identifying the inferior conversion reversibility between the intermedia CuS and the final product S as the primary cause for deteriorating cycling capability. Concerning the different hydrated dimensions of the Cu(H 2 O) 6 2+ and Cu(H 2 O) 2 + , the strategy of “spatial confinement” is proposed to alter the oxidation path of Cu 2 S and prevent the formation of the intermedia CuS. To ensure efficient S incorporation into the spatially confined carbon matrix, selenium (Se) is employed to “cut” the S 8 into short-chain molecules. Consequently, the well-designed S–Cu cathode achieves a one-step four-electron reaction and exhibits superior electrochemical stability with an average capacity attenuation of 0.034% during 700 cycles. Our study provides an in-depth understanding of the conversion mechanism for the S–Cu cathode within the spatial-confinement environment and renders valuable insights for developing advanced conversion-type cathodes in aqueous energy-storage device.}, archive = {J_ANGEW}, author = {Yunsheng Zhang and Meng Yao and Peng Jing and Yuchen Fu and Weichao Wang and Yun Zhang and Qinzhi Lai and Qian Wang}, doi = {10.1002/anie.202501205}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501205}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving a highly reversible four-electron redox of S/Cu2S for aqueous Zn/S─Cu battery}, volume = {64}, year = {2025}, }
• (2025). Zwitterionic dipeptide surface functionalization of detonation nanodiamond for enhanced control in biological environments. ANGEW, 64(25), e202501202. (www)

  @article{ , abstract = {Utilizing nanoparticles as innovative theranostic agents for biomedical applications requires full control over the material's properties to dictate their interactions within a biological environment. Owing to its versatile surface chemistry and high biocompatibility, nanodiamond (ND) represents a promising platform for novel healthcare treatments. To ensure the performance and safety of NDs, their properties and behavior must remain unchanged upon administration, a key challenge in nanomedicine. Recently, zwitterionic surface modifications have emerged as new strategies to substantially improve protein-repelling properties and biocompatibility of nanomaterials. Using for the first time covalently conjugated zwitterionic dipeptides as surface modulators for ND particles, we were able to provide a readily accessible, reproducible, and tunable functionalization. The obtained particles demonstrate enhanced colloidal stability and conservation of particle size over a broad pH range and in different protein-containing media compared to the starting material. By simple selection of different dipeptides, we can carefully tailor the biocompatibility and cellular uptake of functionalized NDs. We reveal the functionalized NDs’ behavior in biologically relevant 3D organotypic models and how different dipeptide-functionalized NDs interact with squamous epithelium ex vivo. The results pave the way for various applications, e.g., biosensing, tissue engineering or targeted drug delivery of these highly biologically suitable nanoparticles.}, archive = {J_ANGEW}, author = {Elisabeth Mayerhoefer and Himalaya Parajuli and Mihaela-Roxana Cimpan and Daniela Elena Costea and Harsh Nitin Dongre and Anke Krueger}, doi = {10.1002/anie.202501202}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501202}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zwitterionic dipeptide surface functionalization of detonation nanodiamond for enhanced control in biological environments}, volume = {64}, year = {2025}, }
• (2025). Chiral luminescent ion pair (CLIP) strategy enables amorphous platinum complexes circularly polarized phosphorescence. ANGEW, 64(25), e202501011. (www)

  @article{ , abstract = {Chiral ion-pairing (CIP) has been developed as an effective chirality transfer strategy from chiral ionic species to its achiral counter-ionic substrate. When the achiral counter-ions were endowed with luminescent properties, the resultant chiral luminescent ion pair (CLIP) will open a new window for high-performance chiral luminescence. In this research, three pairs of CLIP molecules featuring the platinum complexes as achiral cationic luminophores and the chiral anion (CA) as chiral source were constructed. The CLIP molecules demonstrate circularly polarized phosphorescence (CPP) with quantum yields (Φ PL ) up to 71.5%, dissymmetry factor ( g cpp ) values of 1.8 × 10 −2 in amorphous state and g cpp up to −0.99 in cholesteric liquid crystal (CLC). Results show that the chiroptical properties can be assigned to the chirality transfer from the CAs to the formed twisted dimeric or oligomeric self-assemblies of platinum complex cations. This research presents a new approach for achieving high-performance chiral luminescence of amorphous chiral metal complexes, providing a concise model for revealing the chirality transfer in CLIP materials.}, archive = {J_ANGEW}, author = {Sheng-Qi Qiu and Mei-Yuan Li and Hua-Yue Li and Yao Xiao and Jiannan Xiao and Gayathri Parthasarathy and Zhengong Meng and Wai-Yeung Wong and Zhen-Qiang Yu}, doi = {10.1002/anie.202501011}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202501011}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral luminescent ion pair (CLIP) strategy enables amorphous platinum complexes circularly polarized phosphorescence}, volume = {64}, year = {2025}, }
• (2025). High partial molar volume polymer electrolyte for upgraded lithium metal batteries. ANGEW, 64(25), e202500896. (www)

  @article{ , abstract = {Lithium (Li) metal batteries combined with solid electrolytes represent a highly promising technology for high-energy-density storage systems. However, their cycling performance encounters inferior stability due to the continuous growth of Li-dendrites. The initial motivation for Li-dendrite growth theoretically arises from the high chemical potential difference (∆ µ ) at the electrolyte/Li metal interface, yet the effectiveness of ∆ µ regulation lacks experimental validation. Here, we experimentally present the impact of ∆µ on the growth of Li-dendrites through manipulation of the partial molar volume of Li + ( ) in the polymer electrolyte. By weakening Li–O coordination structure, the as-produced high- polymer electrolyte (108.5 cm 3 mol −1 ) shows 83% decrease in ∆µ (289 J mol −1 ) compared with conventional counterparts, thereby enabling stable cycling for >10 months in a Li||Li cell and >2000 cycles in a Li||Cu cell with an average Coulombic efficiency (CE) of 96%. To one's delight, a practical cylindrical Li||Li[Ni 0.5 Co 0.3 Mn 0.2 ]O 2 cell with capacity of 0.62 Ah delivers excellent cycle stability with negligible capacity attenuation over 85 cycles at 0.2 C. The beneficial role of high is leveraged to introduce a new dimension in polymer electrolyte engineering, highlighting the underexplored design strategy of regulating interfacial ∆µ to rejuvenate practical lithium metal batteries.}, archive = {J_ANGEW}, author = {Dongjiang Chen and Wei Chen and Bowen Zhang and Yin Hu and Shuying Wang and Tianyu Lei and Miao He and Yuxin Fan and Mingjie Zhou and Yichao Yan and Yuanpeng Liu and Xianfu Wang and Genqiang Zhang}, doi = {10.1002/anie.202500896}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202500896}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High partial molar volume polymer electrolyte for upgraded lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Conformationally locked Peptide–DNA nanostructures for CRISPR-amplified activity-based sensing. ANGEW, 64(25), e202500649. (www)

  @article{ , abstract = {We introduce a new class of chemical probes for activity-based sensing of proteases, termed cleavable, locked initiator probes (CLIPs). CLIPs contain a protease-cleavable peptide linked between two programmable DNA strands—an “initiator” DNA and a shorter “blocking” DNA. These DNA sequences are designed to hybridize, creating a “locked” hairpin-like structure. Upon proteolytic cleavage, the initiator strand is released, triggering the activation of CRISPR-Cas12a enzymes and producing an amplified fluorescence response. CLIPs generate more than 20-fold turn-on signals at room temperature (25 °C), significantly outperforming commercial probes by yielding ∼40-fold lower limits of detection (LOD) at 100-fold lower concentrations. Their versatility enables the detection of various disease-relevant proteases—including the SARS-CoV-2 main protease, caspase-3, matrix metalloproteinase-7, and cathepsin B—simply by altering the peptide sequence. Importantly, CLIPs detect cathepsin B in four different colorectal cancer cell lines, highlighting their clinical potential. Taken together, the sensitivity (LOD: ∼88 pM), selectivity, and rapid assay time (down to 35 min), combined with the ability to operate in complex biological media with minimal sample preparation, position CLIPs as powerful chemical tools for activity-based sensing of functional enzymes.}, archive = {J_ANGEW}, author = {Dylan M. Snider and Mackenzie L. Coffin and Brian J. Armijo and Ryan Khetan and Mark W. Duchow and Anna Capasso and Devleena Samanta}, doi = {10.1002/anie.202500649}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202500649}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformationally locked Peptide–DNA nanostructures for CRISPR-amplified activity-based sensing}, volume = {64}, year = {2025}, }
• (2025). Excited-state basicity diverts the site-selectivity of aromatic deuteration: Application to the late-stage labeling of pharmaceuticals. ANGEW, 64(25), e202500627. (www)

  @article{ , abstract = {Isotope labeling, particularly with deuterium ( 2 H), plays a critical role in drug discovery due to its ease of incorporation and its potential to switch unwanted metabolic transformations. Deuterium incorporation can enhance drug stability, affect pharmacokinetics, and alter metabolism pathways. Current deuterium labeling methods focus on hydrogen isotope exchange (HIE), and typically rely on the use of transition metal catalysis. Herein, we present a metal-free approach for aromatic HIE, utilizing photoexcitation in deuterated hexafluoroisopropanol (HFIP- d 1 ). By exploiting the enhanced basicity of excited-state aromatics, this method achieves selective deuteration at positions often inaccessible by traditional methods. The approach is efficient and was demonstrated across a broad number of complex drug molecules. Transient absorption spectroscopy confirms the formation of deuterated arenium ions.}, archive = {J_ANGEW}, author = {Eva Rivera-Chao and Javier Corpas and Giovanni Lonardi and Volker Derdau and Alessandro Ruffoni and Daniele Leonori}, doi = {10.1002/anie.202500627}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202500627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Excited-state basicity diverts the site-selectivity of aromatic deuteration: Application to the late-stage labeling of pharmaceuticals}, volume = {64}, year = {2025}, }
• (2025). Enantiodivergent radical alkylation by synergistic lewis-acid-enzyme and photoredox catalysis. ANGEW, 64(25), e202500338. (www)

  @article{ , abstract = {Artificial metalloenzymes (ArMs) and photoenzymatic catalysis represent two cutting-edge approaches to creating new enzyme reactivity. However, the potential of merging these two strategies remains underdeveloped for enantiocontrolled biotransformations. Herein, we develop a synergistic metalloenzymatic and photoredox catalysis platform to enable enantiodivergent radical alkylation of 2-acyl imidazoles. Specifically, cupin proteins are redesigned to function as copper(II)-based Lewis-acid-enzymes (LAses), which, in synergy with tripyridinyl-ruthenium-based photoredox catalysis, precisely control the generation, reactivity, and selectivity of abiological radicals, thereby unlocking non-natural enzyme reactivity. Powered by protein engineering, repurposed photo-LAses facilitate the green and efficient synthesis of diverse enantioenriched α-chiral ketones in high enantioselectivity (both enantiomers accessible, up to 97% yield and 98.5:1.5 enantiomeric ratio [er]). Detailed mechanistic studies suggest a radical addition to the metalloenzymatic enolate pathway and explain the switched selectivity from dark to photoconditions.}, archive = {J_ANGEW}, author = {Jiawei Zhang and Qiaoyu Zhang and Ran Ge and Aokun Liu and Bin Chen and Zihan Zhang and Beibei Zhao and Jinhai Yu and Yue Zhao and Lu Yu and Mingfeng Cao and Binju Wang and Xiaoqiang Huang}, doi = {10.1002/anie.202500338}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202500338}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantiodivergent radical alkylation by synergistic lewis-acid-enzyme and photoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Origin of lithium dendrite formation in sulfide-based electrolyte. ANGEW, 64(25), e202500245. (www)

  @article{ , abstract = {The Li dendrite growth during battery cycles is a well-known obstacle to the practical application of sulfide-based electrolytes (SEs), notably Li 3 PS 4 (LPS), in lithium metal batteries. However, there remains a significant gap in understanding the mechanism for Li dendrite penetration through SEs exhibiting high shear modulus. Herein, we investigate the optimum deposition sites for Li 0 atoms within typical LPS configurations, encompassing crystalline, lithiated, and degraded structures, with their ionization levels employed as descriptors to determine the preferential state (Li 0 /Li + ) of the interstitial Li. Our results suggest that both bulk LPS and solid electrolyte interphase (SEI) layer are predicted to be electrochemically resistive upon Li 0 deposition. Conversely, the defect configurations, including cracks and grain boundaries (GBs), exhibit a marked propensity to promote the electrochemical deposition of Li 0 atoms. Once Li dendrites initiate, the electronic conductivities of those defects undergo a significant surge, catalyzing electron transport and facilitating Li dendrite penetration through the SEs, ultimately driving dendrite growth. Furthermore, we underscore the synergistic interaction between Li dendrite propagation and crack formation within SEs, offering deeper insights into the electrochemical-mechanical degradation mechanism in SEs. These findings present novel methodologies for predicting Li dendrite growth and open up alternative perspectives in SE engineering.}, archive = {J_ANGEW}, author = {Wei Hao and Yujun Li and Gyeong S. Hwang and Yakun Liu and Zheng Liang}, doi = {10.1002/anie.202500245}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202500245}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Origin of lithium dendrite formation in sulfide-based electrolyte}, volume = {64}, year = {2025}, }
• (2025). Enhancing built-in electric field via balancing interfacial atom orbit hybridization at Boride@Sulfide heterostructure for hydrogen evolution reaction. ANGEW, 64(25), e202425657. (www)

  @article{ , abstract = {Exploring nonprecious metal-based catalysts for cathodic hydrogen evolution reaction (HER) has facilitated the realization of hydrogen economy toward water electrolysis in alkaline media. However, the difficult water dissociation process for the Volmer step (H 2 O → H* + OH*) and the subsequent unsuitable OH* adsorption energy on nonprecious metal-based catalysts severely reduce the kinetics of HER. Herein, the universal synthesis for a series of transition metal (Ti, Zr, Hf, V, Nb, Ta, Cr, Mo, and W)-based boride@sulfide heterostructured catalysts is realized by using the molten-salt method to conduct the in situ boronization of commercial sulfides. Significantly, WB 2 @WS 2 heterostructured catalyst exhibits excellent catalytic activity and stability for HER. Balancing interfacial atom orbit hybridization between W( d )-B( s , p ) and W( d )-S( s , p ) at WB 2 @WS 2 heterostructured interface enhances the built-in electric field. In situ Raman spectroscopy and density functional theory calculation results reveal that the strong built-in electric field in WB 2 @WS 2 optimizes the adsorption and desorption of OH* intermediate, reducing the energy barrier of the rate-determining step (OH* desorption step), and thus favoring the enhancement of catalytic performance toward HER.}, archive = {J_ANGEW}, author = {Mengna Wang and Chuanchuan Yan and Tianfu Liu and Shuo Wang and Ziqi Liao and Feifan Guo and Qi Wang and Zhenyu Li and Guoxiong Wang}, doi = {10.1002/anie.202425657}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202425657}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing built-in electric field via balancing interfacial atom orbit hybridization at Boride@Sulfide heterostructure for hydrogen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Saarvienin A—A novel glycopeptide with potent activity against drug-resistant bacteria. ANGEW, 64(25), e202425588. (www)

  @article{ , abstract = {A member of a new family of glycopeptides, named saarvienin A, was isolated from a rare actinomycete Amycolatopsis sp. YIM10. Extensive NMR and MS analyses revealed a halogenated peptide core comprising four amino acids cyclized via a ureido linkage with an exocyclic 2-hydroxy-3-(4-hydroxyphenyl)propyl residue connected to a five-sugar/aminosugar chain. Two of the three aminosugars constitute the N -methylated and N , O -dimethylated derivatives of eremosamine (4- epi -vancosamine) that have not been reported in any natural product. Saarvienin A exhibits potent activity against a range of Gram-positive bacteria, effectively overcoming resistance to several frontline antibiotics in clinical isolates. It demonstrates an eight-fold reduction in minimum inhibitory concentrations (MICs) against methicillin-resistant, vancomycin-intermediate, and daptomycin-resistant Staphylococcus aureus compared to vancomycin.}, archive = {J_ANGEW}, author = {Amninder Kaur and Jaime Felipe Guerrero-Garzón and Sari Rasheed and Martin Zehl and Franziska Fries and Bernd Morgenstern and Sergey B. Zotchev and Rolf Müller}, doi = {10.1002/anie.202425588}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202425588}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Saarvienin A—A novel glycopeptide with potent activity against drug-resistant bacteria}, volume = {64}, year = {2025}, }
• (2025). Organic cation modulation in hybrid zirconium halides for high-performance flexible X-ray imaging. ANGEW, 64(25), e202425385. (www)

  @article{ , abstract = {Exploiting novel materials featuring high-quality zero-dimensional structure, remarkable lattice stability, and minimal defects represents an efficacious strategy for enhancing the detection performance of X-ray scintillators. Here, we design and synthesize two novel zirconium-based organic-inorganic hybrid metal halides (OIMHs), C 14 H 40 N 4 ZrCl 8 and C 6 H 16 N 2 ZrCl 6 . Based on the steric hindrance effect of organic cations, the distance between [ZrCl 6 ] 2− polyhedra was designed, and the electronic coupling interactions among polyhedra were adjusted, thus precisely engineering excellent zero-dimensional materials. Simultaneously, the stronger N─H + ···Cl − bond is introduced to avoid structural instabilities and more defects due to the bigger organic cation in C 14 H 40 N 4 ZrCl 8 . As expected, C 14 H 40 N 4 ZrCl 8 exhibits more remarkable luminescence behavior compared to C 6 H 16 N 2 ZrCl 6 . The photophysics process involving self-trapped excitons and defects is elaborately expounded using first-principles calculations, luminescence properties, and stabilities. Finally, a flexible and large-area scintillation screen based on C 14 H 40 N 4 ZrCl 8 is fabricated and attains a high spatial resolution of 21.35 lp mm −1 and a lower limit of detection of 2.270 µGy air s −1 , outperforming the resolution of most blue-emitting scintillation screens. These results imply that the zirconium-based OIMHs possess significant potential applications for medical diagnostics, security scanning, and non-destructive testing.}, archive = {J_ANGEW}, author = {Lili Han and Minglang Yuan and Hang Xie and Guoqiang Peng and Youkui Xu and Xiushuo Zhang and Zhipeng Ci and Zhiwen Jin}, doi = {10.1002/anie.202425385}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202425385}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic cation modulation in hybrid zirconium halides for high-performance flexible X-ray imaging}, volume = {64}, year = {2025}, }
• (2025). Periodic patterning of matter in non-equilibrium liesegang-type structures. ANGEW, 64(25), e202425292. (www)

  @article{ , abstract = {Bottom-up self-organization of unordered molecules into ordered, spatiotemporal patterns of complex structures through non-equilibrium reaction–diffusion (RD) processes is ubiquitous in nature across all scales. Unlike many RD processes that typically lead to transient patterns, periodic precipitation reactions governed by the Liesegang phenomenon are distinguished by the formation of stable, permanent structures. This unique characteristic makes them valuable tools in the development of hierarchical multifunctional materials, an area that has seen significant progress in recent decades. This review summarizes the fundamental aspects of the Liesegang phenomenon, focusing on the key characteristics, compositional features, inherent properties, and formation mechanisms of Liesegang patterns in chemical systems, while also highlighting their occurrence in biological and geological settings. We discuss recent advancements in applying periodic precipitation to address global challenges in microelectronics and environmental monitoring, concluding with a forward-looking perspective on the promising future applications of the Liesegang periodic precipitation in materials science, nanotechnology, medicine, and environmental engineering.}, archive = {J_ANGEW}, author = {Patrick Damacet and Katherine A. Mirica}, doi = {10.1002/anie.202425292}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202425292}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Periodic patterning of matter in non-equilibrium liesegang-type structures}, volume = {64}, year = {2025}, }
• (2025). On-demand regulation of catalytic DNA circuits using phosphorylated charge reversal peptides. ANGEW, 64(25), e202425113. (www)

  @article{ , abstract = {Catalytic DNA circuits have emerged as a powerful tool for high-performance biosensing application; however, the establishment of a safe and efficient in vivo delivery system remains a critical bottleneck. Peptides serve as attractive carriers due to their rich chemical diversity, excellent biocompatibility, high loading capacity, and specific binding ability, making them ideal candidates for the on-demand regulation of DNA circuits—yet remains largely unexplored. In this study, we developed a multifunctional enzyme-responsive peptide (ERP) for the efficient loading and specific intracellular delivery and release of catalytic circuitry probes through a phosphorylation-based charge reversal procedure. This ERP-programmed catalytic DNA circuit enables the precise, spatially controllable in vivo imaging of microRNA (miRNA). The multifunctional cationic peptide formed a stable nanocomplex with anionic DNA cargo via strong electrostatic interactions, thus protecting the DNA probes from degradation in biological environments. Moreover, with the ability to actively targeting tumor cells and facilitate endogenous phosphorylation-guided release of DNA probes, this multifunctional peptide could significantly reduce the nonspecific delivery of probes to healthy tissues, thereby minimizing unwanted off-site signal leakage. By the integration of cell-selective delivery and site-specific stimulation, this endogenously regulated and multiply guaranteed DNA circuit system paves a simple yet effective way for disease diagnosis.}, archive = {J_ANGEW}, author = {Qingqing Zhang and Shanshan Yu and Shizhen He and Yuqiu He and Xiaoqing Liu and Fuan Wang}, doi = {10.1002/anie.202425113}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202425113}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-demand regulation of catalytic DNA circuits using phosphorylated charge reversal peptides}, volume = {64}, year = {2025}, }
• (2025). An A-T hoogsteen base pair in a naked DNA hairpin motif: A protein-recognized conformation. ANGEW, 64(25), e202425067. (www)

  @article{ , abstract = {In duplex DNA, A-T and G-C form Watson-Crick base pairs, and Hoogsteen pairing only dominates upon protein binding or DNA damage. Using NMR, we show that an A-T Hoogsteen base pair previously observed in crystal structures of transposon DNA hairpins bound to TnpA protein forms in solution even in the absence of TnpA. This Hoogsteen base pair, located adjacent to a dinucleotide apical loop, exists in dynamic equilibrium with a minor Watson-Crick conformation (population ∼11% and lifetime ∼55 µs). Extending the apical loop to three residues inverted the equilibrium, making Watson-Crick the dominant state and the Hoogsteen conformation recognized by TnpA a minor state (population ∼14% and lifetime ∼28 µs). The propensity for Hoogsteen pairing depended on apical loop residues, which form contacts directly or indirectly stabilizing the Hoogsteen conformation. A structure survey did not reveal Hoogsteen pairing near RNA apical loops making them unique to DNA. Our results demonstrate that Hoogsteen can be the dominant state even in naked unmodified duplex DNA and identify 5′-CTT(T/C)AG-3′ as a DNA-specific apical loop motif stabilized by Hoogsteen pairing. Hoogsteen base pairs may be prevalent in DNA hairpins forming during replication and transcription, with broad implications for the genomic landscape.}, archive = {J_ANGEW}, author = {Serafima Guseva and Or Szekely and Ainan Geng and Kai Smith and Supriya Pratihar and Yeongjoon Lee and Linshu Li and Sophie M. Korn and Stephanie Gu and Hashim M. Al-Hashimi}, doi = {10.1002/anie.202425067}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202425067}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An A-T hoogsteen base pair in a naked DNA hairpin motif: A protein-recognized conformation}, volume = {64}, year = {2025}, }
• (2025). Enhancing solar-to-hydrogen peroxide conversion efficiency by promoting the two-electron water oxidation pathway via modulating the main electron transition orbital. ANGEW, 64(25), e202425054. (www)

  @article{ , abstract = {Photosynthetic hydrogen peroxide (H 2 O 2 ) production involves coupling oxygen reduction and water oxidation half-reactions. However, the low efficiency of water oxidation constrains the overall solar-to-hydrogen peroxide conversion efficiency under natural conditions. The two-electron water oxidation pathway holds potential for enhanced photocatalytic H 2 O 2 synthesis, yet its regulatory mechanisms and detailed understanding remain inadequately explored. Herein, we construct donor–acceptor (D–A) conjugated polymers with pyrene as the electron donor and triazine as the electron acceptor. By optimizing the connecting positions of the electron acceptors at the 2,7 positions of the electron donors, the main excited state is regulated from S 1 to S 2 , leading to the electron transition from the lower HOMO-1 orbital. This modulation effectively enhances the oxidation capacity of the photocatalyst, enabling it to undergo two-electron water oxidation reaction (2e − WOR) for H 2 O 2 production. Consequently, the WOR activity reaches a remarkable efficiency of 2560 µmol g −1 h −1 , corresponding to a solar-to-chemical conversion (SCC) efficiency of up to 0.94%. This strategy of modulating electronic transition orbitals to enhance the water oxidation capacity of the material significantly improves photocatalytic performance and facilitates its application in natural environments.}, archive = {J_ANGEW}, author = {Huijie Yan and Yuyan Huang and Minhui Shen and Jianqiao Xu and Yu-Xin Ye and Gangfeng Ouyang}, doi = {10.1002/anie.202425054}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202425054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing solar-to-hydrogen peroxide conversion efficiency by promoting the two-electron water oxidation pathway via modulating the main electron transition orbital}, volume = {64}, year = {2025}, }
• (2025). The role of convex edge site in fully-exposed pt cluster catalyst for hydrogen production. ANGEW, 64(25), e202424816. (www)

  @article{ , abstract = {Achieving a precise understanding of the active site structure has long been an ultimate goal in fundamental heterogeneous catalysis research, yet it remains exceptionally challenging in nanocluster catalysis. In Pt-catalyzed dehydrogenation reactions, such as cyclohexane dehydrogenation for liquid organic carriers (LOHC), previous efforts have provided valuable insights into the size effects of nanoclusters. However, the optimal geometry of the active sites has remained elusive and, at times, contradictory. In this study, we investigate the geometric effect and the active site structure in fully-exposed Pt clusters supported on ceria that exhibit superior activity in cyclohexane dehydrogenation (11.4 mol mol Pt − ¹ s − ¹), characterized by small coordination numbers, high metal utilization efficiency, and abundant convex edge sites. Through a combination of experimental and theoretical approaches, we demonstrate that the convex edge sites predominant within the fully-exposed Pt clusters outperform other active structures (e.g., terrace sites, hollow sites, etc.) in dehydrogenation reactions. These convex edge sites are not only efficient in C─H activation but, more notably, are also resistant to detrimental carbonaceous intermediates, hence enabling high and long-lived H 2 production activity.}, archive = {J_ANGEW}, author = {Mi Peng and Chengyu Li and Huaying Meng and Xuan Tang and Maolin Wang and Jie Zhang and Junzhong Xie and Qingxin Zhang and Fengya Tong and Hao Tian and Hao Wang and Lei Song and Hongyang Liu and Sheng Dai and Geng Sun and Ding Ma}, doi = {10.1002/anie.202424816}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202424816}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The role of convex edge site in fully-exposed pt cluster catalyst for hydrogen production}, volume = {64}, year = {2025}, }
• (2025). Highly sensitive thianthrene covalent trimer room-temperature phosphorescent materials for low-concentration oxygen detection. ANGEW, 64(25), e202424669. (www)

  @article{ , abstract = {Oxygen is ubiquitous and vital to life, industry, and environmental safety, so accurate and reliable oxygen sensing and detection are of great significance, especially for oxygen in the low concentration range. Herein, two pure organic metal-free room-temperature phosphorescence (RTP) materials were developed using a covalent trimerization strategy of thianthrene (TA), which exhibit high oxygen sensitivity and fluorescence-RTP separated dual emission due to the moderate spin-orbit coupling (SOC). Compared with traditional metal-organic complexes, the oxygen sensitivity of RTP is improved by about two orders of magnitude, especially facilitating accurate quantitative detection of low-concentration oxygen. Leveraging oxygen quenching-induced changes in emission color and intensity, coupled with computer-assisted image processing, a simple oxygen monitoring device was established to realize real-time and accurate detection of low-concentration oxygen, promoting the industrial practical application in many related fields.}, archive = {J_ANGEW}, author = {Zhiqiang Yang and Junjie Qian and Shuaiqiang Zhao and Yingbo Lv and Zhe Feng and Shiyin Wang and Hanbing He and Shi-Tong Zhang and Haichao Liu and Bing Yang}, doi = {10.1002/anie.202424669}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202424669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly sensitive thianthrene covalent trimer room-temperature phosphorescent materials for low-concentration oxygen detection}, volume = {64}, year = {2025}, }
• (2025). Carbon-supported single Fe/Co/Ni atom catalysts for water oxidation: Unveiling the dynamic active sites. ANGEW, 64(25), e202424629. (www)

  @article{ , abstract = {Extensive research has been conducted on carbon-supported single-atom catalysts (SACs) for electrochemical applications, owing to their outstanding conductivity and high metal atom utilization. The atomic dispersion of active sites provides an ideal platform to investigate the structure–performance correlations. Despite this, the development of straightforward and scalable synthesis methods, along with the tracking of the dynamic active sites under catalytic conditions, remains a significant challenge. Herein, we introduce a biomass-inspired coordination confinement strategy to construct a series of carbon-supported SACs, incorporating various metal elements, such as Fe, Co, and Ni. We have systematically characterized their electronic and geometric structure using various spectroscopic and microscopic techniques. Through in situ X-ray absorption spectroscopy (XAS), atomic scanning transmission electron microscopy (STEM), and electron paramagnetic resonance (EPR) analyses, it is demonstrated that the single atoms undergo structural rearrangement to form amorphous (oxy)hydroxide clusters during oxygen evolution reaction (OER), where the newly formed oxygen-bridged dual metal M─O─M or M─O─M’ (M/M’ = Fe, Co, Ni) moieties within these clusters play key role in the OER performance. This work provides essential insights into tracking the actual active sites of SACs during electrochemical OER.}, archive = {J_ANGEW}, author = {Wenchao Wan and Liqun Kang and Alexander Schnegg and Olaf Ruediger and Zongkun Chen and Christopher S. Allen and Longxiang Liu and Sonia Chabbra and Serena DeBeer and Saskia Heumann}, doi = {10.1002/anie.202424629}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202424629}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon-supported single Fe/Co/Ni atom catalysts for water oxidation: Unveiling the dynamic active sites}, volume = {64}, year = {2025}, }
• (2025). Synthesis of sensitive RNAs using fluoride-cleavable groups as linkers and amino-group protection. ANGEW, 64(25), e202424560. (www)

  @article{ , abstract = {A chemical method suitable for the synthesis of RNAs containing modifications such as N 4-acetylcytidine (ac4C) that are unstable under the basic and nucleophilic conditions used by standard RNA synthesis methods is described. The method uses the 4-(( t -butyldimethylsilyl)oxy)-2-methoxybutanoyl (SoM) group for the protection of exo -amino groups of nucleobases and the 4-(( t -butyldimethylsilyl)oxy)-2-((aminophosphaneyl)oxy)butanoyl (SoA) group as the linker for solid phase synthesis. RNA cleavage and amino deprotection are achieved using fluoride under the same conditions used for the removal of the 2′-OH silyl protecting groups. Using this method, a wide range of electrophilic and base-sensitive groups including those that play structural and regulatory roles in biological systems and those that are artificially designed for various purposes are expected to be able to be incorporated into any position of any RNA sequences. As a proof of concept, several RNAs containing the highly sensitive ac4C epitranscriptomic modification was synthesized and purified with RP HPLC. MALDI MS analysis indicated that the ac4C modification is completely stable under the fluoride deprotection conditions. The sensitive RNA synthesis method is expected to be able to overcome the long-lasting obstacle of accessing various modified sensitive RNAs to projects in areas such as epitranscriptomics, molecular biology and the development of nucleic acid therapeutics.}, archive = {J_ANGEW}, author = {Alexander Apostle and Manoj Perera and Daniel Middleton and William Wittstock and Rohith Awasthy and Yinan Yuan and Shiyue Fang}, doi = {10.1002/anie.202424560}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202424560}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of sensitive RNAs using fluoride-cleavable groups as linkers and amino-group protection}, volume = {64}, year = {2025}, }
• (2025). Retained oxygen regulation in oxide-derived copper for promoted CO2 electroreduction toward multicarbon products. ANGEW, 64(25), e202423889. (www)

  @article{ , abstract = {Electrochemical CO 2 reduction to multicarbon products provides an attractive route to store intermittent renewable electricity as high value-added chemicals. Oxide-derived Cu (OD-Cu) has been widely investigated for its tunable selectivity toward multicarbon (C 2+ ) products; however, it still remains a challenge to understand and regulate the retained oxygen of OD-Cu in the complex reconstruction process. In this work, we investigate thickness determined residual oxygen in OD-Cu, using CuO nanosheets as prototype precatalysts. When the thickness of CuO precatalyst decreased to 1.6 nm, the enhancement of the ability to retain oxygen are achieved, leading to selective C 2+ production with Faradaic efficiency of around 80% over a wide current density range of 300–700 mA cm −2 with a peak value of 84.6% at 700 mA cm −2 . Long-time molecular dynamics simulations reveal the enhanced stability of Cu–CuO structure with the layers of removed oxygen increased, favoring *CHO formation and *OC-CHO coupling toward C 2+ products; structural characterizations and electrochemical results further demonstrate the reconstructed stacked nanosheets with high oxygen retention capacity and easily reoxidized metallic Cu sites. This work underscores the crucial role of the retained oxygen for the OD-Cu performance and provides insights into designing OD-Cu with oxygen retention to enhance C 2+ products formation.}, archive = {J_ANGEW}, author = {Huan Wang and Hai Xiang Yang and Yi Ning Xu and Huai Qin Fu and Xin Yan Li and Jing Jing He and Qiang Niu and Jia Chen Wu and Hai Yang Yuan and Peng Fei Liu and Hua Gui Yang}, doi = {10.1002/anie.202423889}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202423889}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Retained oxygen regulation in oxide-derived copper for promoted CO2 electroreduction toward multicarbon products}, volume = {64}, year = {2025}, }
• (2025). Photosynthesis of NH3 from NO3− using CH4 in homogenous rhenium catalysis. ANGEW, 64(25), e202423543. (www)

  @article{ , abstract = {We present Re catalysis of one-pot synthesis of NH 3 from NO 3 − using CH 4 as a reductant under UV light irradiation at room temperature. NO 3 − leads to environmental issues such as water contamination, eutrophication, and biodiversity loss. In a natural system and a sewage facility, NO 3 − can be detoxified to N 2 using hydrogen donors by a microbial process. However, it is better to convert NO 3 − to NH 3 rather than N 2 . To develop a desirable process of NO 3 − to NH 3 for a sustainable society, it is required that the reducing agent is derived from a renewable resource/energy. Thus, we turned our attention to CH 4 , which has a high affinity with renewable resource/energy since it can be produced from livestock waste. Therefore, our system reported here is to directly convert NO 3 − to NH 3 using CH 4 with light energy.}, archive = {J_ANGEW}, author = {Genta Nakamura and Masaya Sakurai and Yohei Kametani and Yudai Kawasaki and Yoshihito Shiota and Kazunari Yoshizawa and Seiji Ogo and Takahiro Matsumoto}, doi = {10.1002/anie.202423543}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202423543}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photosynthesis of NH3 from NO3− using CH4 in homogenous rhenium catalysis}, volume = {64}, year = {2025}, }
• (2025). Enzymatic amination for stereocontrolled functionalization of cyclohexanones. ANGEW, 64(25), e202423530. (www)

  @article{ , abstract = {Functionalizing the symmetric carbonyl carbon of cyclohexanone to achieve stereocontrol, resulting in saturated cyclohexanes with either cis / trans or axial stereochemistry, poses significant challenges in chemical synthesis, and existing methodologies are limited. In this study, we present an enzymatic reductive amination strategy to attain this objective. By engineering the enzyme pocket of the sole imine reductase (IRED) M5, we successfully synthesized over 80 cis / trans and axially chiral 4-substituted cyclohexylamines in a stereo-complementary fashion, adhering to industrial standards, via the reductive amination of 4-substituted cyclohexanones. Mechanistically, the reshaping of the enzyme pocket allows the optimized variants to distinguish between different imine precursors and selectively bind their specific configurations with favorable binding energies, thereby facilitating the generation of stereochemically distinct products. We propose that this stereocontrolled-functionalization strategy could be extended to a broader range of cyclohexylamines with diverse substituents.}, archive = {J_ANGEW}, author = {Juzhang Yan and Jinping Bao and Chengsen Cui and Xin Li and Lujia Yang and Yaqing Ma and Shu-Shan Gao}, doi = {10.1002/anie.202423530}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202423530}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzymatic amination for stereocontrolled functionalization of cyclohexanones}, volume = {64}, year = {2025}, }
• (2025). Benchmark paraffin adsorption in a super-hydrophobic porous coordination polymer with blade-like circular phenyl nanotraps. ANGEW, 64(25), e202423371. (www)

  @article{ , abstract = {Selective capture of paraffin from olefin that permits one-step purification of olefin is significantly important, yet developing adsorbents with high selectivity and hydrophobicity remains a daunting challenge. Although aromatic environments can enhance paraffin affinity and hydrophobicity through nonpolar interactions, water adsorption still occurs in regions distant from the aromatic rings, as well as in secondary pores that are always overlooked. Herein, we reported an ultramicroporous porous coordination polymer (ZnFPCP) featuring blade-like circular phenyl paraffin nanotraps. As further validated by density functional tight binding (DFTB) calculations, grand canonical Monte Carlo (GCMC) simulations, and in situ Fourier-tansform infrared absorption (FT-IR) analysis, these ultramicroporous paraffin nanotraps created by surrounding benzene rings enhance the paraffin-selective adsorption, and the segmented spaces between adjacent nanotraps in the blade-like structure, combined with hydrophobic petal-like secondary pore channels enclosed by fluorinated functional groups, further mitigate the water co-adsorption. Remarkably, ZnFPCP exhibited outstanding ideal adsorption solution theory (IAST) selectivity (C 3 H 8 /C 3 H 6 : 2.08, C 2 H 6 /C 2 H 4 : 2.93) under ambient conditions and record-breaking C 3 H 8 /C 2 H 6 uptake at low pressures. Breakthrough experiments demonstrated the excellent performance of ZnFPCP in olefin purification, affording the exceptional productivity of ultra-high purity (99.99%) for C 3 H 6 and C 2 H 4 . Robust stability and super hydrophobicity highlight its potential in harsh industrial application scenarios.}, archive = {J_ANGEW}, author = {Fuqiang Chen and Niko Prasetyo and Shigeyoshi Sakaki and Ken-ichi Otake and Susumu Kitagawa}, doi = {10.1002/anie.202423371}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202423371}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Benchmark paraffin adsorption in a super-hydrophobic porous coordination polymer with blade-like circular phenyl nanotraps}, volume = {64}, year = {2025}, }
• (2025). Diamond chemistry: Advances and perspectives. ANGEW, 64(25), e202418683. (www)

  @article{ , abstract = {Diamond as a material has many unique properties. Its high optical dispersion, extraordinarily high mechanical strength, and unparalleled thermal conductivity have long made it a material of interest for applications such as high-temperature electronics and as wear-resistance coatings. More recently, diamond has emerged as a material with a wide range of applications in chemistry and biology. The high intrinsic stability of diamond, coupled with the ability to modify diamond surfaces with a wide range of inorganic, organic, and biological species via highly stable covalent linkages, provides a wealth of opportunity to couple diamond's chemical properties with its extraordinary physical properties. The practical utility of diamond has been greatly expanded in recent years through dramatic advances in the ability to produce diamond in bulk, thin film, and nanoparticle form, with controlled doping and purity at modest cost. These advances, together with diamond's highly stable and tunable surface chemistry with versatility of physical structure enable a wide range of emerging applications of interest to chemists, including quantum science, biomedicine, energy storage, and catalysis. Yet, to fully exploit the unique properties of diamond, some formidable chemical challenges lie ahead. We begin by reviewing some of the features of diamond that are of particular importance to the chemistry community. We aim to highlight some of the important applications where diamond chemistry plays a key role, identify some of the key observations, and outline some of the future directions and opportunities for diamond in the chemical world.}, archive = {J_ANGEW}, author = {Nianjun Yang and Anke Krueger and Robert J. Hamers}, doi = {10.1002/anie.202418683}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202418683}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diamond chemistry: Advances and perspectives}, volume = {64}, year = {2025}, }
• (2025). Reactive cysteines in proteins are the dominant reductants for Platinum(IV) prodrug activation in live cells. ANGEW, 64(25), e202416396. (www)

  @article{ , abstract = {The intracellular reduction of Pt(IV) prodrugs is crucial for their anticancer efficacy. However, the major components responsible for the reduction of Pt(IV) complexes within live cells remain elusive. Herein, we developed an aminoluciferin-functionalized Pt(IV) complex, Pt-Luc , that can be used as a bioluminescent reporter for real-time monitoring of Pt(IV) reduction in live cancer cells by capturing immediate bioluminescent signals from the released aminoluciferin. Utilizing this powerful reporter, we found that the reduction of Pt(IV) prodrugs in live cancer cells significantly slows down when cysteine levels are reduced, while the levels of glutathione do not impact the reduction rate. Further investigation reveals that reactive cysteines in proteins, rather than small-molecule thiols, play a primary role in reducing the Pt(IV) complex. In vivo studies reveal a substantial 63% decrease in bioluminescence from Pt-Luc in thiol-blocking tumors in mice, reinforcing the pivotal role of reactive cysteines in Pt(IV) reduction. This study provides valuable insights into the activation mechanisms of Pt(IV) prodrugs in live cells and in vivo, enhancing our understanding of prodrug activation beyond buffer systems or fixed cells.}, archive = {J_ANGEW}, author = {Shu Chen and Wang Peng and Houzong Yao and Zhiqin Deng and Zhao Yue and Gongyuan Liu and Jiaqian Xu and Naixin Lin and Weikang Xu and Jianbo Yue and Guangyu Zhu}, doi = {10.1002/anie.202416396}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {25}, pages = {e202416396}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reactive cysteines in proteins are the dominant reductants for Platinum(IV) prodrug activation in live cells}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Self-optimized reconstruction of Metal–Organic frameworks introduces cation vacancies for selective electrosynthesis of hydrogen peroxide. ANGEW, 64(24), e202582401. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582401}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202582401}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Self-optimized reconstruction of Metal–Organic frameworks introduces cation vacancies for selective electrosynthesis of hydrogen peroxide}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Cyclo-p5 − revisited: The surprisingly stable uncoordinated pentaphospholide anion (Angew. chem. int. ed. 24/2025). ANGEW, 64(24), e202510375. (www)

  @article{ , archive = {J_ANGEW}, author = {Moritz J. Ernst and Andrey Petrov and Mirjam Schröder and Björn Corzilius and Christian Müller}, doi = {10.1002/anie.202510375}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202510375}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Cyclo-p5 − revisited: The surprisingly stable uncoordinated pentaphospholide anion (Angew. chem. int. ed. 24/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: A bench-stable fluorophosphine nickel(0) complex and its catalytic application (Angew. chem. int. ed. 24/2025). ANGEW, 64(24), e202510369. (www)

  @article{ , archive = {J_ANGEW}, author = {Franziska Flecken and Arjun Neyyathala and Toni Grell and Schirin Hanf}, doi = {10.1002/anie.202510369}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202510369}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: A bench-stable fluorophosphine nickel(0) complex and its catalytic application (Angew. chem. int. ed. 24/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Optimizing the selectivity of CH4 electrosynthesis from CO2 over cuprates through Cu─O bond length descriptor (Angew. chem. int. ed. 24/2025). ANGEW, 64(24), e202510022. (www)

  @article{ , archive = {J_ANGEW}, author = {Yunze Xu and Yu Zhang and Hongyan Zhao and Lei Shi and Zhenbao Zhang and Xueyan Li and Zhen Xue and Heqing Jiang and Yongfa Zhu and Jiawei Zhu}, doi = {10.1002/anie.202510022}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202510022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Optimizing the selectivity of CH4 electrosynthesis from CO2 over cuprates through Cu─O bond length descriptor (Angew. chem. int. ed. 24/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Data–Knowledge-dual-driven electrolyte design for fast-charging lithium ion batteries (Angew. chem. int. ed. 24/2025). ANGEW, 64(24), e202510008. (www)

  @article{ , archive = {J_ANGEW}, author = {i Yang and Nan Yao and Yu-Chen Gao and Xiang Chen and Yu-Xin Huang and Shuo Zhang and Han-Bing Zhu and Lei Xu and Yu-Xing Yao and Shi-Jie Yang and Zheng Liao and Zeheng Li and Xue-Fei Wen and Peng Wu and Ting-Lu Song and Jin-Hao Yao and Jiang-Kui Hu and Chong Yan and Jia-Qi Huang and Qiang Zhang}, doi = {10.1002/anie.202510008}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202510008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Data–Knowledge-dual-driven electrolyte design for fast-charging lithium ion batteries (Angew. chem. int. ed. 24/2025)}, volume = {64}, year = {2025}, }
• (2025). Gang li. ANGEW, 64(24), e202508663. (www)

  @article{ , archive = {J_ANGEW}, author = {Gang Li}, doi = {10.1002/anie.202508663}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202508663}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gang li}, volume = {64}, year = {2025}, }
• (2025). Chen wang. ANGEW, 64(24), e202508077. (www)

  @article{ , archive = {J_ANGEW}, author = {Chen Wang}, doi = {10.1002/anie.202508077}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202508077}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chen wang}, volume = {64}, year = {2025}, }
• (2025). Beyond structure: Methylation fine-tunes stability and folding kinetics of bcl2Mid G-quadruplex. ANGEW, 64(24), e202507544. (www)

  @article{ , abstract = {Cytosine methylation, a key epigenetic modification in the regulation of gene expression, raises intriguing questions about its role in the formation and thermodynamic stability of G-quadruplex (G4) structures. We investigated the impact of the 5-methylcytosine residue (C m ) on the well-characterized bcl2Mid G4 structure that forms in a GC-rich region of the B-cell lymphoma 2 (BCL2) gene promoter, which influences its expression. Using solution-state NMR and biophysical techniques, we discovered an unexpected sequence-specific effect of C m on the folding kinetics of bcl2Mid G4. Specifically, substituting cytosine at position C6 with C6 m slows down G4 folding kinetics and influences the equilibrium between major and minor structures in the presence of K + ions. Notably, the increased population of the minor structure enabled the characterization of its previously unidentified topology. Additionally, the presence of a single C m residue induces local structural rearrangements in the major G4 structure and decreases its thermodynamic stability. Furthermore, we found that the zinc finger 3 motif of the Sp1 transcription factor preferentially binds to the minor G4 structure. These results suggest that C m not only influences G4 polymorphism but may also regulate interactions with transcription factors, potentially affecting the regulation of gene expression.}, archive = {J_ANGEW}, author = {Nataša Medved and Mirko Cevec and Uroš Javornik and Jurij Lah and San Hadži and Janez Plavec}, doi = {10.1002/anie.202507544}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202507544}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Beyond structure: Methylation fine-tunes stability and folding kinetics of bcl2Mid G-quadruplex}, volume = {64}, year = {2025}, }
• (2025). Optimizing charge separated synergistic binding sites in self-healing crystalline porous organic salts for benchmark trace Alkyne/Alkene separation. ANGEW, 64(24), e202507442. (www)

  @article{ , abstract = {The separation of trace alkyne (C 2 H 2 /C 3 H 4 ) impurities from alkenes (C 2 H 4 /C 3 H 6 ) is a significant but challenging process to produce polymer-grade C 2 H 4 and C 3 H 6 . Herein, we reported an optimally designed charge-separated organic framework, crystalline porous organic salt (CPOS-1), with confined polar channels for highly efficient alkyne/alkene separation. CPOS-1 exhibits excellent stability, remarkably high C 2 H 2 (18.4 cm 3 g −1 ) and C 3 H 4 (20.9 cm 3 g −1 ) uptakes at 0.01 bar and 298 K, and benchmark C 2 H 2 /C 2 H 4 (25.1) and C 3 H 4 /C 3 H 6 (43.9) separation selectivities for 1/99 alkyne/alkene mixtures. The practical alkyne/alkene separation performance was completely identified by breakthrough-column experiments under various conditions with excellent cycle stability and high alkene productivities (C 2 H 4 : 216.6 L kg −1 ; C 3 H 6 : 162.4 L kg −1 ). Theoretical calculations indicated that pore aperture in CPOS-1 acts as a tailored single-molecule trap, where alkynes are captured by multiple synergistic electropositive and electronegative sites, thus enhancing alkyne recognition. Furthermore, the ease of rehealing facilitates its practical application, transcending the limitations of the metal-organic frameworks (MOFs) and covalent organic frameworks (COFs).}, archive = {J_ANGEW}, author = {Yunjia Jiang and Lingyao Wang and Guolong Xing and Changhong Liu and Guangzu Xiong and Danling Sun and Jianbo Hu and Weidong Zhu and Zonglin Gu and Banglin Chen and Teng Ben and Yuanbin Zhang}, doi = {10.1002/anie.202507442}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202507442}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimizing charge separated synergistic binding sites in self-healing crystalline porous organic salts for benchmark trace Alkyne/Alkene separation}, volume = {64}, year = {2025}, }
• (2025). Acyclic quaternary stereocenters via catalytic asymmetric cross-couplings with unactivated alkyl N-hydroxyphthalimide esters. ANGEW, 64(24), e202506883. (www)

  @article{ , abstract = {While significant advancements have been made in creating quaternary stereocenters (all-carbon substituents) within cyclic frameworks, generating acyclic quaternary stereocenters poses a more formidable task due to increased conformational flexibility. Herein, we report an enantioselective synthesis of compounds containing acyclic quaternary stereocenters through an iron-catalyzed alkylation reaction between an acyclic tertiary alkyl source and an unactivated primary alkyl source. This method not only facilitates the rapid construction of sterically hindered motifs but also effectively enhances the saturation level of the molecule. Key to this method is an outer-sphere C─C bond formation mechanism, where enantioselectivity is governed by a cooperative triple catalysis system that combines photoredox, chiral Lewis acid, and iron catalysis. A series of compounds featuring acyclic quaternary stereocenters is produced under mild reaction conditions, and various transformations are presented to illustrate the potential applications of this approach. A comprehensive mechanistic study supports the crucial S H 2 (bimolecular homolytic substitution) mechanism.}, archive = {J_ANGEW}, author = {Lian-Jie Li and Jun-Chun Zhang and Jia-Yu Tang and Hui Yu and Ze-Peng Yang}, doi = {10.1002/anie.202506883}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506883}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Acyclic quaternary stereocenters via catalytic asymmetric cross-couplings with unactivated alkyl N-hydroxyphthalimide esters}, volume = {64}, year = {2025}, }
• (2025). Bis(pinacolato)Diboron-enabled nickel-catalyzed regio- and enantioselective reductive [3 + 2] annulation of β-bromoenones with alkynes. ANGEW, 64(24), e202506873. (www)

  @article{ , abstract = {Chiral five-membered cyclic tertiary alcohols are important structural motifs in functional materials, pharmaceuticals, and bioactive molecules. Hence, developing efficient methodologies for synthesizing compounds featuring these privileged scaffolds represents a crucial pursuit within synthetic chemistry. Herein, we present a regio- and enantioselective Ni-catalyzed strategy for the reductive [3 + 2] annulation of β-bromoenones with alkynes, providing convenient access to chiral five-membered cyclic tertiary alcohols with high levels of regio-, and enantioselectivity via axial chirality transfer to central chirality. The utilization of an environmentally sustainable bis(pinacolato)diboron (B 2 pin 2 ) is crucial for the success of this asymmetric reductive cyclization reaction. Simultaneously, the mild reaction environment greatly enhances functional group compatibility. This has been demonstrated by the broad substrate scope, late-stage functionalizations of bioactive compounds or drug molecules, and subsequent transformations. Amongst, it is worth emphasizing that these functionally enriched chiral five-membered cyclic tertiary alcohols can efficiently participate in Diels–Alder reactions to synthesize enantioenriched polycyclic and heterocyclic molecules, thereby further validating the significance of introducing a cyclopentadiene skeleton. The preliminary mechanistic studies revealed the mode of action of B 2 pin 2 in mononuclear Ni-catalyzed asymmetric reductive [3 + 2] annulation reactions and density functional theory (DFT) calculations clarified the origin of the experimentally observed regio- and enantioselectivity.}, archive = {J_ANGEW}, author = {Wangyang Li and Yanping Zheng and Yunya Gu and Shanshan Cheng and Jinhui Xie and Yong Lu and Shanglin Chen and Qiuling Song}, doi = {10.1002/anie.202506873}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506873}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bis(pinacolato)Diboron-enabled nickel-catalyzed regio- and enantioselective reductive [3 + 2] annulation of β-bromoenones with alkynes}, volume = {64}, year = {2025}, }
• (2025). Correction to “Hypoxia induced by upconversion-based PDT: Towards highly effective bioreductive therapy in tumor synergistically”. ANGEW, 64(24), e202506853. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202506853}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506853}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Hypoxia induced by upconversion-based PDT: Towards highly effective bioreductive therapy in tumor synergistically”}, volume = {64}, year = {2025}, }
• (2025). Remote spin-center shift enables activation of distal benzylic C─O and C─N bonds. ANGEW, 64(24), e202506771. (www)

  @article{ , abstract = {A spin-center shift (SCS) is a radical process that commonly involves a 1,2-radical shift along with the elimination of an adjacent leaving group by a two-electron ionic movement. The conventional SCS process is largely limited to 1,2-radical translocation, while a remote SCS event involving 1, n -radical translocation over a greater distance to enable distal bond functionalization remains largely underexplored. Herein, we report the boryl radical-promoted distal deoxygenation and deamination of free benzylic alcohols and simple benzylic amines, respectively, through a remote SCS event. The reaction was initiated by the addition of a 4-dimethylaminopyridine (DMAP)-boryl radical to the carbonyl oxygen atom of a benzoate or benzamide. Then, radical translocation took place across the aromatic ring to promote benzylic C─O or C─N bond cleavage. The resulting radical intermediate subsequently coupled with various alkenes to afford a wide range of alkylated products. The proposed mechanistic pathway was supported by experimental investigations.}, archive = {J_ANGEW}, author = {Li-Wen Hui and Yee Lin Phang and Chen-Yang Ye and Jin-Yu Lai and Feng-Lian Zhang and Yao Fu and Yi-Feng Wang}, doi = {10.1002/anie.202506771}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506771}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote spin-center shift enables activation of distal benzylic C─O and C─N bonds}, volume = {64}, year = {2025}, }
• (2025). Unprecedented “off-pathway” [2+2] cycloaddition-retroelectrocyclization reaction between an unsymmetric alkyne and tetracyanoquinodimethane. ANGEW, 64(24), e202506536. (www)

  @article{ , abstract = {In recent years, the [2+2] cycloaddition-retroelectrocyclization (CA-RE) reaction between electron-rich alkynes and electron-deficient alkenes has emerged as one of the most effective synthetic routes to prepare a large variety of molecular and polymeric electron donor–acceptor systems. Besides its simplicity, fast rate, and high yield, this reaction may also display complete and predictable regioselectivity, as in the case when tetracyanoquinodimethane (TCNQ) is used in combination with unsymmetric, activated alkynes. Here, we report the first example of a [2+2] CA-RE reaction between TCNQ and an aniline-activated alkyne following an “inverted” regiochemistry, thus leading to the exclusive formation of an unexpected regioisomer in contrast to the expected one. A combined experimental and theoretical study helped us to unravel the peculiar reaction mechanism underlying the regioselectivity switching.}, archive = {J_ANGEW}, author = {Oscar Fernández-Vera and Luca Sagresti and Luis M. Mateo and Tomas Torres and Giuseppe Brancato and Giovanni Bottari}, doi = {10.1002/anie.202506536}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506536}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unprecedented “off-pathway” [2+2] cycloaddition-retroelectrocyclization reaction between an unsymmetric alkyne and tetracyanoquinodimethane}, volume = {64}, year = {2025}, }
• (2025). Towards high-performance aqueous zn-organic batteries via using i−-based active electrolyte. ANGEW, 64(24), e202506466. (www)

  @article{ , abstract = {Organic cathodes possess inherent structural diversity and fast redox kinetics, showing great application prospects in aqueous Zn batteries. Nevertheless, most of the reported organic cathodes display low average working voltage resulting in poor energy density. Herein, diquinoxalino [2,3-a:2′,3′-c] phenazine (HATN)@CMK-3 composite is utilized as cathode for aqueous zinc battery, which combines the Zn 2+ and H + co-storage and I − /I 0 conversion by introducing I − -based active additive into 0.5 M Zn(OTf) 2 electrolyte. The in situ/ex situ analyses and computational studies disclose that HATN@CMK-3 with C═N groups not only stores Zn 2+ and H + ions at low potential but also acts as a substrate to promote the conversion reaction of I − /I 0 at high potential. Accordingly, the Zn//HATN@CMK-3 cell delivers a high average voltage of 0.75 V, prominent long-life (10 000 cycles) and, high energy density (198 Wh kg −1 ). Remarkably, under high mass loading (10 mg cm −2 ) or low-temperature conditions, the cell still achieves decent capacity and cycle stability.}, archive = {J_ANGEW}, author = {Lei Yan and Lei Liu and Chaoyi Qiu and Yutian Xiang and Haoxiang Yu and Liyuan Zhang and Ting-Feng Yi and Yonggang Wang and Jie Shu}, doi = {10.1002/anie.202506466}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506466}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards high-performance aqueous zn-organic batteries via using i−-based active electrolyte}, volume = {64}, year = {2025}, }
• (2025). Modification of [2.2]Paracyclophanes via Cobalt/Salox-catalyzed enantioselective electrooxidative or photoredox C─H acyloxylation and alkoxylation. ANGEW, 64(24), e202506465. (www)

  @article{ , abstract = {Chiral [2.2]paracyclophanes (PCPs) have widespread application in asymmetric catalysis and materials science. However, enantioselective C─H activation of PCPs remains elusive and challenging due to steric hindrance, which differs significantly from conventional aryl C─H bonds. Herein, we present a cobalt/Salox-catalyzed enantioselective dehydrogenative C─H acyloxylation and alkoxylation of racemic PCPs with carboxylic acids and alcohols under electrooxidative or photoredox conditions. This innovative approach leverages traceless electrons or oxygen to replace traditional stoichiometric metal oxidants, allowing the reaction to proceed under mild conditions. The method enables the efficient synthesis of oxygenated optically enriched PCPs, achieving yields of up to 50% with 99% ee, as well as up to 49% yields and 99% ee for the recovered starting materials, resulting in exceptional s -factors of up to 1057. The reaction exhibits a broad scope, accommodating a diverse array of carboxylic acids, including complicated natural products and pharmaceutical molecules. This strategy not only provides an efficient route for synthesizing optically enriched PCP compounds but also highlights the potential of electrooxidative and photoredox methodologies in asymmetric C─H activation reactions.}, archive = {J_ANGEW}, author = {Fan-Rui Huang and Ming-Ya Teng and Hui Qiu and Qi-Jun Yao and Bing-Feng Shi}, doi = {10.1002/anie.202506465}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506465}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modification of [2.2]Paracyclophanes via Cobalt/Salox-catalyzed enantioselective electrooxidative or photoredox C─H acyloxylation and alkoxylation}, volume = {64}, year = {2025}, }
• (2025). Solar-driven reversible hydrogen storage of sodium Cyclohexanolate/Phenoxide pair. ANGEW, 64(24), e202506275. (www)

  @article{ , abstract = {Reversible hydrogen storage is a key challenge for the implementation of hydrogen energy, with dehydrogenation being particularly difficult because of its endothermic nature, slow kinetics, poor selectivity, etc. Solar energy-driven hydrogen uptake/release represents an interdisciplinary approach that provides an effective solution to those problems. Herein, we report the solar-driven reversible hydrogen uptake of 4.9 wt.% over sodium cyclohexanolate/phenoxide pair, achieving over 99.9% conversion and selectivity in both hydrogenation and dehydrogenation via photocatalysis without external heating. Notably, the initial dehydrogenation rate reaches 23.4 that is ca. 2 orders of magnitude higher than thermocatalysis. The superior photocatalytic performance stems from the synergy between high- and low-frequency light, i.e., low-frequency light mainly provides heat, high-frequency light drives the desorption of product from the catalyst surface. This approach offers a path toward a sustainable solar-driven hydrogen energy system.}, archive = {J_ANGEW}, author = {Khai Chen Tan and Qijun Pei and Jiafeng Yu and Lin Liu and Jiayin Li and Li Han and Yang Yu and Zhao Li and Alexis Munyentwali and Jiaquan Guo and Yuting Wang and Li Rao and Teng He and Ping Chen}, doi = {10.1002/anie.202506275}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506275}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solar-driven reversible hydrogen storage of sodium Cyclohexanolate/Phenoxide pair}, volume = {64}, year = {2025}, }
• (2025). A bench-stable fluorophosphine nickel(0) complex and its catalytic application. ANGEW, 64(24), e202506271. (www)

  @article{ , abstract = {We herein present a fluorophosphine-based nickel(0) complex [Ni(PFPh 2 ) 4 ] ( 1 ), which is highly stable in air and water. [Ni(PFPh 2 ) 4 ] can be obtained from a one-pot reaction of [Ni(MeCN) 4 ](BF 4 ) 2 with Ph 2 P(═O)–PPh 2 , involving a unique in situ reduction of Ni(II) to Ni(0) and a simultaneous fluorination by the BF 4 − anion. This complex does not only incorporate a nickel center in the zero-oxidation state, resulting from a Ni(II) precursor, but also includes fluorophosphine ligands, which typically disproportionate immediately in solution. The application of [Ni(PFPh 2 ) 4 ] as highly stable Ni(0) pre-catalyst in combination with additional phosphine ligands, such as dppf (1,1′-bis(diphenylphosphino)ferrocene), in various coupling reactions uncovers its high catalytic activity and versatility, which is superior to [Ni(COD) 2 ] (COD═cycloocta-1,5-diene) as conventional Ni(0) source.}, archive = {J_ANGEW}, author = {Franziska Flecken and Arjun Neyyathala and Toni Grell and Schirin Hanf}, doi = {10.1002/anie.202506271}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506271}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bench-stable fluorophosphine nickel(0) complex and its catalytic application}, volume = {64}, year = {2025}, }
• (2025). Synthesis and characterization of circumtetracene: Unraveling structure-property relationships of circumacenes. ANGEW, 64(24), e202506248. (www)

  @article{ , abstract = {Circumacenes have garnered significant interest in both fundamental science and nanoelectronics due to their unique electronic structures. However, their synthesis and investigations into the structure–property relationships present considerable challenges. In this work, we report the successful synthesis and characterization of a stable circumtetracene derivative in crystalline form. For comparison, a new circumanthracene derivative was also prepared. The electronic properties of both compounds were systematically investigated using both various experimental techniques and theoretical calculations. It was found that circumtetracene exhibits a dominant local aromatic nature with small open-shell diradical character, while circumanthracene displays a closed-shell global aromatic character. Both compounds show amphoteric redox behavior with narrow energy gaps. The dication of circumtetracene and the dianions of circumtetracene and circumanthracene can be obtained experimentally through chemical oxidation and reduction, all displaying intense NIR absorptions. Furthermore, the electronic properties of these derivatives were compared with those of previously reported circumacene analogues, revealing a transition in electronic structure from closed-shell global aromatic to singlet open-shell local aromatic configurations upon π-extension. This work provides a comprehensive exploration of the structure-property relationships within the circumacene series, offering valuable insights for the design and synthesis of novel multizigzag-edged nanographenes with tunable electronic properties.}, archive = {J_ANGEW}, author = {Qing Jiang and Junjie He and Fuzhong Gu and Yixuan Jiang and Ning Li and Xiaojing Fang and Zhenni Hu and Zhonghao Gui and Wangdong Zeng and Chunyan Chi}, doi = {10.1002/anie.202506248}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202506248}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and characterization of circumtetracene: Unraveling structure-property relationships of circumacenes}, volume = {64}, year = {2025}, }
• (2025). Crystalline silagermenides as powerful synthons: Unraveling π-bonding and lone pair effects in the multiple bonds of heavier main group analogs of the vinyl anion. ANGEW, 64(24), e202505940. (www)

  @article{ , abstract = {Compared to common vinyl anions, their heavier heteronuclear analog, silagermenides [R 2 Si═GeR]ˉ, remain exceedingly rare. Herein, we present a systematic investigation of silagermenides, synthesized via a straightforward desilylation route. We delve into the bonding characteristics, revealing a weak, polarized Si─Ge π bond with a significant nonbonded lone pair character at the β-Si position. This β-Si exhibits predominantly nucleophilic behavior, while the α-Ge position demonstrates subtly electrophilic tendencies, despite the presence of a vinylic, formally anionic Ge atom. This leads to the formation of silagermenide complexes in an unprecedented η 2 coordination mode, as well as various silagermenes and germylenes with unconventional substituents. We also document the facile cleavage of the ambiphilic Si═Ge double bond, resulting in the transfer of a formal doubly reduced silylene and a formal germyliumylidene. Our findings expand the understanding of heavier main group analogs of the vinyl anion, with important implications for their synthesis and reactivity.}, archive = {J_ANGEW}, author = {Xue-Yi He and Qiuming Liang and Yanbo Mei and Liu Leo Liu}, doi = {10.1002/anie.202505940}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505940}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystalline silagermenides as powerful synthons: Unraveling π-bonding and lone pair effects in the multiple bonds of heavier main group analogs of the vinyl anion}, volume = {64}, year = {2025}, }
• (2025). Catalytic asymmetric synthesis of chiral caged hydrocarbons as arenes bioisosteres. ANGEW, 64(24), e202505803. (www)

  @article{ , abstract = {The utilization of caged hydrocarbons as bioisosteres for arenes, especially the phenyl ring, in bioactive compounds has resulted in significant enhancements in potency, solubility, and metabolic stability. These improvements highlight the potential of C(sp 3 )-rich polycyclic scaffolds as a promising motif for the development of drug candidates. However, this strategy has also increased the structural complexity of these molecules, posing synthetic challenges in controlling the chirality of caged and highly decorated bioactive scaffolds. Over the past two years, remarkable progress has been achieved in catalytic asymmetric methodologies for the synthesis of caged hydrocarbons, significantly advancing their utility in chiral drug discovery and development. This minireview provides a comprehensive summary of recent breakthroughs in the catalytic asymmetric synthesis of chiral caged hydrocarbons, encompassing bicyclo[n.1.1]alkanes, cubanes, and related three-dimensional scaffolds. Additionally, we highlight the intriguing applications of enantiomerically pure caged hydrocarbons in biological studies. It is anticipated that this minireview will inspire further advancements in the enantioselective synthesis of these pharmaceutically valuable caged hydrocarbons.}, archive = {J_ANGEW}, author = {Xue-Chun Yang and Ji-Jie Wang and Yuanjiu Xiao and Jian-Jun Feng}, doi = {10.1002/anie.202505803}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505803}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic asymmetric synthesis of chiral caged hydrocarbons as arenes bioisosteres}, volume = {64}, year = {2025}, }
• (2025). High-pressure synthesis of ultra-incompressible beryllium tungsten nitride pernitride BeW10N14(N2). ANGEW, 64(24), e202505778. (www)

  @article{ , abstract = {For the activation of nitrogen and its reduction to ammonia, transition metals are crucial in biological as well as industrial processes. So far, only a few binary transition metal compounds with nitrogen dimer anions are known, whereas a ternary compound has remained undiscovered as yet. Here, we report on the synthesis and properties of the first ternary transition metal compound, namely, BeW 10 N 14 (N 2 ), which exhibits dinitrogen anions. It was synthesized in a high-temperature high-pressure approach from W 2 Be 4 N 5 . The crystal structure, elucidated with synchrotron radiation, unites WN 7 capped trigonal prisms with intriguing BeN 6 octahedra and (N 2 )-anions. Elastic and electronic properties of the title compound were corroborated by DFT calculations, revealing simultaneous ultra-incompressible and metallic behavior. The synthesis and investigation of the first ternary transition metal nitride with dinitrogen units opens the door to a new field of research on nitride and pernitride chemistry.}, archive = {J_ANGEW}, author = {Georg Krach and Lukas Brüning and Sebastian Ambach and Elena Bykova and Nico Giordano and Björn Winkler and Maxim Bykov and Wolfgang Schnick}, doi = {10.1002/anie.202505778}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505778}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-pressure synthesis of ultra-incompressible beryllium tungsten nitride pernitride BeW10N14(N2)}, volume = {64}, year = {2025}, }
• (2025). Antibacterial siderophores of pandoraea pathogens and their impact on the diseased lung microbiota. ANGEW, 64(24), e202505714. (www)

  @article{ , abstract = {Antibiotic-resistant bacteria of the genus Pandoraea , frequently acquired from the environment, are an emerging cause of opportunistic respiratory infections, especially in cystic fibrosis (CF) patients. However, their specialized metabolites, including niche and virulence factors, remained unknown. Through genome mining of environmental and clinical isolates of diverse Pandoraea species, we identified a highly conserved biosynthesis gene cluster ( pan ) that codes for a nonribosomal peptide synthetase (NRPS) assembling a new siderophore. Using bioinformatics-guided metabolic profiling of wild type and a targeted null mutant, we discovered the corresponding metabolites, pandorabactin A and B. Their structures and chelate (gallium) complexes were elucidated by a combination of chemical degradation, derivatization, NMR, and MS analysis. Metagenomics and bioinformatics of sputum samples of CF patients indicated that the presence of the pan gene locus correlates with the prevalence of specific bacteria in the lung microbiome. Bioassays and mass spectrometry imaging showed that pandorabactins have antibacterial activities against various lung pathogens ( Pseudomonas , Mycobacterium , and Stenotrophomonas ) through depleting iron in the competitors. Taken together, these findings offer first insight into niche factors of Pandoraea and indicate that pandorabactins shape the diseased lung microbiota through the competition for iron.}, archive = {J_ANGEW}, author = {Elena Herzog and Keishi Ishida and Kirstin Scherlach and Xiuqiang Chen and Benjamin Bartels and Sarah P. Niehs and Bachar Cheaib and Gianni Panagiotou and Christian Hertweck}, doi = {10.1002/anie.202505714}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505714}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antibacterial siderophores of pandoraea pathogens and their impact on the diseased lung microbiota}, volume = {64}, year = {2025}, }
• (2025). Unveiling the catalytic potential of facet heterojunctions in platinum alloys for oxygen reduction reaction. ANGEW, 64(24), e202505699. (www)

  @article{ , abstract = {Ensuring high-quality activity of proton exchange membrane fuel cells (PEMFCs) while mitigating the degradation of Pt-based alloy catalysts remains challenging. A platinum-skinned truncated octahedral PtNi alloy with (100)/(111) facet heterostructures is synthesized through a low-temperature thermally driven etching strategy, demonstrating exceptional oxygen reduction reaction (ORR) activity and stability. The heterostructure of the Pt skin -PtNi(111) facet destabilizes the *OOH intermediate and promotes the preferential O─O bond cleavage, leading to the optimization of ORR pathway. A linear correlation between the generalized coordination number ( ) and Δ G *OH demonstrates that the facet hetero-sites optimize the adsorption of *OH to the theoretically optimal state through ligand and geometric effects. The optimized PNZC-5A160 catalyst exhibits enhanced ORR activity (2.97 A mg Pt −1 at 0.9 V vs. RHE) and superior H 2 -O 2 single PEMFC performance [mass activity (MA) of 0.5 A mg Pt −1 at 0.9 V iR-free ; peak power density of 1.42 W cm −2 , exceeding the U.S. Department of Energy 2025 targets. After accelerated stress tests, the loss in MA at 0.9 V iR-free and in potential at 0.8 A cm −2 is only 8% and 3.7 mV, respectively, due to the enhanced binding of subsurface Pt and Ni to surface Pt atoms through Pt skin, thereby inhibiting the dissolution of Pt and Ni.}, archive = {J_ANGEW}, author = {Yinlong Wu and Shipeng Geng and Jinchao Liu and Yangyang Liu and Kun Wang and Yi Wang and Shuqin Song}, doi = {10.1002/anie.202505699}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505699}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the catalytic potential of facet heterojunctions in platinum alloys for oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Boron doping-induced ultrahigh ce3+ ratio in amorphous CeO2/GO catalyst for low-concentration CO2 photoreduction. ANGEW, 64(24), e202505668. (www)

  @article{ , abstract = {Direct utilization of diluted CO 2 enables sustainable CO 2 conversion into valuable products, with reduced CeO 2 emerging as an attractive candidate due to its exceptional redox flexibility. The catalytic efficacy of CeO 2 is intimately tied to the electronic structure of 4 f , yet the persistent challenge lies in maintaining a high and stable concentration of Ce 3+ . In this study, we propose a symmetry-breaking-induced amorphization strategy to achieve an exceptionally high Ce 3+ ratio by B doping, which facilitates the reduction of Ce 4+ to Ce 3+ in amorphous CeO 2 . First-principles calculations and infrared spectroscopy reveal that B doping with three excess electrons induces the formation of planar triangular B–O₃ units by disrupting the original high-symmetry structure of CeO 2 , facilitating the spontaneous transition to the amorphous phase. Electronic structure analysis confirms that even a modest 7.5% B doping can significantly elevate the Ce 3+ ratio to 85.7%. The resulting amorphous B-doped CeO 2 /GO shows a remarkable CO 2 -to-CO conversion rate of 249.33 µmol g −1 h −1 (under 15% CO 2 ) and 103.4 µmol g −1 h −1 (under 1% CO 2 ), with 100% selectivity in both cases. This performance highlights how amorphization stabilizes defect states, making amorphous CeO 2 /GO with high Ce 3+ an effective material for CO 2 photoreduction and addressing key challenges in CO 2 capture and utilization.}, archive = {J_ANGEW}, author = {Yanhong Li and Qian Yin and Binbin Jia and Huiqing Wang and Hongfei Gu and Qi Hu and Haosen Yang and Tianqi Guo and Pengfei Hu and Lidong Li and Li-Min Liu and Lin Guo}, doi = {10.1002/anie.202505668}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505668}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boron doping-induced ultrahigh ce3+ ratio in amorphous CeO2/GO catalyst for low-concentration CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Decatungstate-driven photocatalytic pathways for sustainable and cleaner recovery of precious metals. ANGEW, 64(24), e202505651. (www)

  @article{ , abstract = {The recovery of precious metals from waste streams is crucial for sustainable resource utilization but remains hindered by traditional methods involving high toxicity, energy consumption, and environmental pollution. Here, we present a photocatalytic strategy employing hydrothermally synthesized decatungstate ([W 10 O 32 ] 4− ) homogeneous ion catalysts to achieve simultaneous oxidation and reduction of precious metals under ambient conditions. This innovative approach integrates solvent-controlled reaction pathways, enabling efficient dissolution and recovery of precious metals from diverse waste sources, including electronic waste (e-waste), platinum membrane electrodes, and platinum-containing catalysts. The decatungstate catalyst exhibits exceptional performance, with an apparent quantum yield of 0.027%—nearly double that of commercial TiO 2 (0.014%)—and achieves recovery efficiency of 80%–100% for platinum, surpassing 21 tested photocatalysts. The process adheres to a solid-phase dissolution model and remains against ionic interference. Time-dependent density functional theory (TD-DFT) calculations corroborate experimental UV–vis spectra, while electron-hole pair analyses elucidate atomic and molecular contributions to photocatalytic activity. Density functional theory (DFT) further validates the thermodynamic feasibility of the reaction pathways. By combining high efficiency, ambient operational conditions, and scalability, this work establishes decatungstates as a sustainable benchmark for green precious metal recovery, addressing the limitations of traditional methods and advancing innovation in resource circularity.}, archive = {J_ANGEW}, author = {Ya Xie and Ting Zhang and Hongxi Guo and Zijuan Ding and Shuyuan Dong and Yao Chen and Junhui Zhang and Shuhui Guan and Zhenmin Xu and Han Yu and Zhenfeng Bian}, doi = {10.1002/anie.202505651}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decatungstate-driven photocatalytic pathways for sustainable and cleaner recovery of precious metals}, volume = {64}, year = {2025}, }
• (2025). Building a confluence charge transfer pathway in COFs for highly efficient photosynthesis of hydrogen peroxide from water and air. ANGEW, 64(24), e202505621. (www)

  @article{ , abstract = {Sunlight-driven photosynthesis by covalent organic frameworks (COFs) from water and air without using sacrificial reagents is a promising H 2 O 2 fabrication approach but is still restricted by the insufficient charge separation and sluggish 2 e − water oxidation process. Herein, we provide a facile strategy to simultaneously improve charge separation and water oxidation in COFs via confining the charge transfer pathways from two diversion ones to a confluence one through regulating the site of nitrogen in bipyridine. Combining in-situ characterization with computational calculations, we reveal that compared to COF-BD1 containing two diversion charge transfer pathways, the charge transfer pathway in COF-BD2 is confined to a confluence due to the electron-deficiency effect of nitrogen, which greatly accelerates the intermolecular and out-of-plane charge transfer. Via effectively reducing the energy barrier of rate-determining water oxidation reaction (WOR), the subsequent water oxidation process to produce the key *OH intermediate in COF-BD2 is also greatly facilitated, boosting the yield of H 2 O 2 (5211 µmol g −1 h −1 ) from water, oxygen, and light without sacrificial agents or additional energy consumption. We further demonstrate that H 2 O 2 can be efficiently produced by COF-BD2 in a broad pH range, in real water, and in an enlarged reactor using natural sunlight for water decontamination.}, archive = {J_ANGEW}, author = {Yanghui Hou and Fuyang Liu and Jialiang Liang and Zhengmao Li and Peng Zhou and Meiping Tong}, doi = {10.1002/anie.202505621}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505621}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Building a confluence charge transfer pathway in COFs for highly efficient photosynthesis of hydrogen peroxide from water and air}, volume = {64}, year = {2025}, }
• (2025). Engineering bodipy-based Metal–Organic frameworks for efficient full-spectrum photocatalysis in amide synthesis. ANGEW, 64(24), e202505405. (www)

  @article{ , abstract = {Developing photocatalysts that can efficiently utilize the full solar spectrum is a crucial step toward transforming sustainable energy solutions. Due to their light absorption limitations, most photo-responsive metal–organic frameworks (MOFs) are constrained to the ultraviolet (UV) and blue light regions. Expanding their absorption to encompass the entire solar spectrum would unlock their full potential, greatly enhancing efficiency and applicability. Here, we report the design and synthesis of a series of highly stable boron-dipyrromethene (bodipy)-based MOFs (BMOFs) by reacting dicarboxyl-functionalized bodipy ligands with Zr-oxo clusters. Leveraging the acidity of the methyl groups on the bodipy backbone, we expanded the conjugation system through a solid-state condensation reaction with various aldehydes, achieving full-color absorption, thereby extending the band edge into the near-infrared (NIR) and infrared (IR) regions. These BMOFs demonstrated exceptional reactivity and recyclability in heterogeneous photocatalytic activities, including C─H bond activation of saturated aza-heterocycles and C─N bond cleavage of N , N -dimethylanilines to produce amides under visible light. Our findings highlight the transformative potential of BMOFs in photocatalysis, marking a significant leap forward in the design of advanced photocatalytic materials with tunable properties.}, archive = {J_ANGEW}, author = {Binhui Liu and Xu Chen and Yuhao Yang and Mohammad Reza Alizadeh Kiapi and Dhruv Menon and Qianyi Zhao and Guozan Yuan and Luke L. Keenan and David Fairen-Jimenez and Qingchun Xia}, doi = {10.1002/anie.202505405}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505405}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering bodipy-based Metal–Organic frameworks for efficient full-spectrum photocatalysis in amide synthesis}, volume = {64}, year = {2025}, }
• (2025). Dimensionality reduction of Metal–Organic frameworks to monolayers for enhanced electrocatalysis. ANGEW, 64(24), e202505399. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) are potential candidates for electrocatalysis due to their well-defined, tunable structures, and ability to incorporate diverse active sites. However, their inherent insulating nature restricts electron transfer from electrode to remote active sites, leading to diminished catalytic performance. In this work, we present a novel strategy to overcome this limitation by reducing 3D MOFs (3D_MOFs) into monolayered MOFs (monoMOFs) with a thickness of ∼1.8 nm, maximizing the exposure of catalytic sites to the electrode and enhancing electrocatalytic performance. We designed and synthesized a monoMOF incorporating cobalt(II)–porphyrin sites in the linker (monoMOF-Co) for CO 2 electroreduction. After being grafted onto graphene oxide, the monoMOF-Co exhibited a peak faradaic efficiency for CO production (FE CO = 93%), surpassing the performance of a 3D_MOF incorporating the same porphyrin–Co-based linker (3D_MOF-Co, FE CO = 51%). Additionally, monoMOF-Co achieved a turnover frequency of 10 600 h −1 at −0.8 V versus the reversible hydrogen electrode (RHE) and maintained stability over 47 h in a near-neutral aqueous solution. In situ spectroscopic studies further confirmed the distinct electric field environment in the Stern layer between monoMOF-Co and 3D_MOF-Co. Furthermore, similar enhancement effects of monoMOFs over 3D_MOFs were observed in the nitrate and oxygen electroreduction reactions, highlighting the broader applicability of monoMOFs in electrocatalysis.}, archive = {J_ANGEW}, author = {Zi Yang and An Li and Hao Li and Guotao Lai and Yifan Fu and Yufeng Zhang and Kun Wang and Senhai Zeng and Lin Xie and Mufan Li and Jun Gu and Guangxu Lan}, doi = {10.1002/anie.202505399}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505399}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dimensionality reduction of Metal–Organic frameworks to monolayers for enhanced electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Electrostatic potential matching in an anion-pillared framework for benchmark hexafluoroethane purification from ternary mixture. ANGEW, 64(24), e202505355. (www)

  @article{ , abstract = {One-step purification of CF 3 CF 3 from ternary CF 3 CH 2 F/CF 3 CHF 2 /CF 3 CF 3 mixture is crucial since its vital role in the semiconductor industry. However, efficient separation of chemically inert CF₃CF₃ remains challenging due to the difficulty in creating specific recognition sites in porous materials. In this work, we report the first example of anion-pillared MOFs to the separation of fluorinated electronic specialty gases, utilizing the unique electrostatic potential matching in the bipolar pores of SIFSIX-1-Cu to realize a benchmark CF 3 CH 2 F/CF 3 CHF 2 /CF 3 CF 3 separation. SIFSIX-1-Cu exhibits the highest CF 3 CH 2 F and CF 3 CHF 2 adsorption capacity at 0.01 bar, as well as the highest CF 3 CH 2 F/CF 3 CF 3 and CF 3 CHF 2 /CF 3 CF 3 IAST selectivity. Additionally, high-purity (≥ 99.995%) CF 3 CF 3 with record productivity (882.9 L kg −1 ) can be acquired through one-step breakthrough experiment of CF 3 CH 2 F/CF 3 CHF 2 /CF 3 CF 3 (5/5/90). Theoretical calculations further reveal that the coexistence of electronegative SiF 6 2− and partially electropositive H sites promotes SIFSIX-1-Cu to effectively anchor CF 3 CH 2 F and CF 3 CHF 2 through multiple supramolecular interactions.}, archive = {J_ANGEW}, author = {Shuixiang Zou and Wenjing Zhang and Cheng Chen and Danhua Song and Hengbo Li and Yashuang Li and Jinghong Yang and Rajamani Krishna and Mingyan Wu}, doi = {10.1002/anie.202505355}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505355}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrostatic potential matching in an anion-pillared framework for benchmark hexafluoroethane purification from ternary mixture}, volume = {64}, year = {2025}, }
• (2025). Tetranuclear titanium nitride cluster: Dinitrogen cleavage under mild conditions and its reactivity. ANGEW, 64(24), e202505312. (www)

  @article{ , abstract = {Heating the readily available trinuclear Ti dinitrogen complex [{TiCp*( µ -Cl)} 3 ( µ 3 - η 1 : η 2 : η 2 -N 2 )] 1 (Cp* = η 5 -C 5 Me 5 ), originally reported by C. Yélamos and J. Jover, in benzene at 80 °C leads to the cleavage of N≡N bond, forming a tetranuclear titanium nitride cluster [{TiCp*} 4 Cl( µ -Cl) 3 ( µ 3 -N) 2 ] 2 . The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. Kinetics study and density functional theory (DFT) calculations indicate that the energy barrier for the NN bond cleavage in the transformation from 1 to 2 is about 26 kcal mol −1 . Complex 2 exhibits reactivity toward various electrophiles, producing a range of nitrogen-containing compounds in the presence of air, while concurrently regenerating Ti(IV) salts. Furthermore, complex 2 reacts with pinacolborane, leading to the formation of N-B bond derivatives [{TiCp*( µ -NBPin)Cl} 2 ] 3 . When complex 2 – 15 N is treated with pyridine or 4-dimethylaminopyridine (DMAP), it dissociates to form a bent trinuclear Ti nitrido complex [{TiCp*} 3 Cl 3 (L) 2 ( µ - 15 N) 2 ] 4-L (L = py or DMAP).}, archive = {J_ANGEW}, author = {Hanhua Xu and Hanjie Wu and Xiao Chen and Ze-jie Lv and Zhongzhen Wang and Zhenfeng Xi and Junnian Wei}, doi = {10.1002/anie.202505312}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tetranuclear titanium nitride cluster: Dinitrogen cleavage under mild conditions and its reactivity}, volume = {64}, year = {2025}, }
• (2025). Photovoltaic absorber “Glues” for efficient bifacial selenium photovoltaics. ANGEW, 64(24), e202505297. (www)

  @article{ , abstract = {Bifacial solar cells hold great potential for achieving higher power output than conventional monofacial devices by harvesting solar irradiance from both their front and rear surfaces. However, almost all currently reported bifacial devices typically require a sputtered rear transparent conducting oxide electrode, which can damage the underlying layers due to plasma effects during the deposition process. Here, we report a glue-bonding strategy that uses a high-viscosity photovoltaic absorber slurry—in the case of molten selenium (Se)—as the adhesive to bond two charge-transport layer-deposited commercial fluorine-doped tin oxide glasses, directly creating bifacial solar cells without the use of magnetron sputtering. We find that molten Se exhibits relatively high viscosity, high stability, and Newtonian fluid characteristics, facilitating film formation using this strategy. The resulting bifacial Se solar cells exhibit a bifaciality factor of 90.1%, surpassing all types of conventional thin-film solar cells. These cells achieve efficiencies of 8.61% under 1-sun illumination with an albedo of 0.3 and 26.17% under 1000-lux indoor illumination with an albedo of 0.8, with no efficiency loss after 1000 h of ambient storage.}, archive = {J_ANGEW}, author = {Xiaoyan An and Zongbao Li and Xia Wang and Wenbo Lu and Xin Wen and Mingjie Feng and Qingxiang Liu and Zhouqing Wei and Jin-Song Hu and Ding-Jiang Xue}, doi = {10.1002/anie.202505297}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505297}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photovoltaic absorber “Glues” for efficient bifacial selenium photovoltaics}, volume = {64}, year = {2025}, }
• (2025). DNA nanotubule-based nanodevices with ATP-responsive gating for direct cytosolic delivery of nucleic acids and proteins. ANGEW, 64(24), e202505290. (www)

  @article{ , abstract = {Delivering biomacromolecules to the cytosol remains a formidable challenge, as these molecules are predominantly sequestered within endosomes after endocytosis. The limited efficacy of current delivery systems in promoting reliable endosomal escape underscores the need for innovative strategies. Here, we report a DNA origami nanotubule to construct transmembrane delivery nanodevices with size-selective gating and ATP-responsive channel activation. By integrating unilamellar vesicles as large storage compartments, these nanodevices can encapsulate a wide range of macromolecules, including small interfering RNA, messenger RNA, plasmid DNA, and CRISPR-Cas9 ribonucleoprotein complexes. By bypassing traditional endocytic pathways, the nanotubules enable the delivery of substantial payload quantities directly across the plasma membrane. This approach provides a promising platform for delivering macromolecular therapeutics into the cytosol, advancing gene therapy strategies, and broadening their biomedical applications.}, archive = {J_ANGEW}, author = {Di Gao and Ziqi Xu and Xiangli Li and Yuhan Zhao and Qianhao Min and Zixuan Chen and Qin Xu and Ye Tian and Junpeng Xu and Jun-Jie Zhu}, doi = {10.1002/anie.202505290}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505290}, shortjournal = {Angew. Chem. Int. Edit.}, title = {DNA nanotubule-based nanodevices with ATP-responsive gating for direct cytosolic delivery of nucleic acids and proteins}, volume = {64}, year = {2025}, }
• (2025). Cathodic hydroxide ions induce tetrose formation during glycolaldehyde electroreduction to alcohols: A potential CO2-to-carbohydrate pathway. ANGEW, 64(24), e202505274. (www)

  @article{ , abstract = {The electrochemical synthesis of organic compounds from CO 2 can potentially alleviate climate change by hampering the atmospheric accumulation of greenhouse gases. The production of carbohydrates from CO 2 reduction will have promising applications for the manufacturing of valuable, multi-carbon compounds that are traditionally produced from the petrochemical or agricultural industries. In this work, we analyzed the copper-catalyzed electrochemical reduction of glycolaldehyde, a commonly observed trace CO 2 RR product that has been previously proposed as an intermediate for alcohol formation. We determine that glycolaldehyde is not the main intermediate on polycrystalline copper-based electrocatalysts that selectively produce ethanol. In an unbuffered electrolyte, the cathodic hydroxide ions produced induce the coupling of glycolaldehyde to tetroses in the solution phase, yielding a maximum glycolaldehyde-to-sugar conversion of 47.2% under ambient conditions. Using in situ infrared spectroscopy coupled with density functional theory (DFT) calculations, we show that glycolaldehyde reduction to alcohols proceeds via adsorption of its enol tautomer, η 2 (C,C)─CHOH═CHOH. Our findings not only shed light on the C 2 alcohol formation pathways during CO 2 RR, but also imply that a CO 2 electrolyzer can potentially produce C 4 carbohydrates via CO 2 reduction to glycolaldehyde followed by C─C coupling in the solution phase, with only a high local pH needed to drive the tetrose formation step.}, archive = {J_ANGEW}, author = {Ernest Pahuyo Delmo and Haichuan Zhang and Jessa Vispo De Guzman and Rans Miguel Nunag Lintag and Juhee Jang and Yao Yao and Yinuo Wang and Shangqian Zhu and Tiehuai Li and Mingguang Pan and Hongming Xu and King Lun Yeung and Minhua Shao}, doi = {10.1002/anie.202505274}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505274}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cathodic hydroxide ions induce tetrose formation during glycolaldehyde electroreduction to alcohols: A potential CO2-to-carbohydrate pathway}, volume = {64}, year = {2025}, }
• (2025). An enzymatic platform for aniline synthesis through oxidative amination. ANGEW, 64(24), e202505252. (www)

  @article{ , abstract = {Aniline motifs are commonly found in natural products and synthetic molecules. While chemists have developed numerous methods for constructing C(sp 2 )─N bonds, their biocatalytic counterparts in nature are primarily limited to P450-based protein machineries. To address this limitation, we developed a biocatalytic platform for aniline synthesis based on oxidative amination of cyclohexanones. Through directed evolution of a flavin-dependent enzyme Pt OYE, we identified several protein catalysts (e.g., OYE_G3 and OYE_M3) that exhibited activity across a broad array of substrates, enabling the preparation of 40 different secondary and tertiary anilines with various substitution patterns in up to 91% GC conversion. Mechanistic investigations revealed the improved kinetic performance of the evolved variants on the desaturation of imines. Additionally, mutations introduced through protein engineering further reduced the propensity for phenol formation. This enzymatic platform represents a highly promising application of flavin-dependent enzymes, showcasing their great potential in organic synthesis and drug development.}, archive = {J_ANGEW}, author = {Xiang Zhao and Zhen Liu}, doi = {10.1002/anie.202505252}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An enzymatic platform for aniline synthesis through oxidative amination}, volume = {64}, year = {2025}, }
• (2025). Data–Knowledge-dual-driven electrolyte design for fast-charging lithium ion batteries. ANGEW, 64(24), e202505212. (www)

  @article{ , abstract = {Electric vehicles (EVs) starve for minutes-level fast-charging lithium-ion batteries (LIBs), while the heat gathering at high-rate charging and torridity conditions has detrimental effects on electrolytes, triggering rapid battery degradation and even safety hazards. However, the current research on high-temperature fast-charging (HTFC) electrolytes is very lacking. We revolutionized the conventional paradigm of developing HTFC electrolytes integrating with high-throughput calculation, machine-learning techniques, and experimental verifications to establish a data–knowledge-dual-driven approach. Ethyl trimethylacetate was efficiently screened out based on the approach and enabled batteries to work under high temperatures with distinctly restricted side reactions. A stable and highly safe fast-charging (15-min charging to 80% capacity) cycling without Li plating was achieved over 4100 cycles at 45 °C based on 181 Wh kg −1 pouch cells, demonstrating the state-of-the-art in this field.}, archive = {J_ANGEW}, author = {Yi Yang and Nan Yao and Yu-Chen Gao and Xiang Chen and Yu-Xin Huang and Shuo Zhang and Han-Bing Zhu and Lei Xu and Yu-Xing Yao and Shi-Jie Yang and Zheng Liao and Zeheng Li and Xue-Fei Wen and Peng Wu and Ting-Lu Song and Jin-Hao Yao and Jiang-Kui Hu and Chong Yan and Jia-Qi Huang and Qiang Zhang}, doi = {10.1002/anie.202505212}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505212}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Data–Knowledge-dual-driven electrolyte design for fast-charging lithium ion batteries}, volume = {64}, year = {2025}, }
• (2025). Octalenobisterphenylene and its diradical dianionic cyclodimer: Synthesis, structural analysis, and properties. ANGEW, 64(24), e202505161. (www)

  @article{ , abstract = {Octalenobisterphenylene 1 (also known as terphenylene dimer) was synthesized from 3,3′,5,5′-tetraaryl-substituted biaryl by tert -butyllithium-mediated cyclization followed by oxidative coupling. This one-pot two-step protocol facilitated the successive formation of four four-membered and two eight-membered rings. Treatment of 1 with sodium metal, followed by crystallization from THF, yielded the remarkable diradical dianion [( 1 •– ) 2 ] 2− , where the two molecular halves are connected by four σ bonds. The cyclodimerization is driven by the pronounced reactivity and strain of the central six-membered ring within the [3]phenylene subunit. The structure and diradical nature of [(Na + ) 2 ( 1 •– ) 2 ] were confirmed through X-ray crystallography, DFT computations, and 1 H NMR and ESR spectra. These investigations revealed that the two spins, one on each molecular half, exhibit minimal mutual interaction.}, archive = {J_ANGEW}, author = {Ming-Lun Pan and Herdya S. Torchon and Heena Tawa and Zheng Wei and Wei-Ting Ou and Mu-Jeng Cheng and Marina A. Petrukhina and Yao-Ting Wu}, doi = {10.1002/anie.202505161}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Octalenobisterphenylene and its diradical dianionic cyclodimer: Synthesis, structural analysis, and properties}, volume = {64}, year = {2025}, }
• (2025). Theory-guided design of surface-enhanced Ni–Mn diatomic site catalysts for efficient seawater electrolysis via the degradation of high ionization potential organic pollutants. ANGEW, 64(24), e202505094. (www)

  @article{ , abstract = {In response to energy shortages and hard-to-degrade chemical pollution, especially high ionization potential (IP) organic pollutants, this study developed a novel photoelectrocatalyst, Ni-Mn@OBN, for degrading IP pollutants in seawater and generating hydrogen. Incorporating Ni–Mn dual atoms into an O-doped boron nitride (OBN) framework, Ni-Mn@OBN, shows excellent stability and HER performance. Density functional theory (DFT) analysis revealed its low Gibbs free energy change (Δ G H* = 0.03 eV) for HER, outperforming Pt (111). Achieving an ultralow overpotential of 43.8 mV at 500 mA cm⁻ 2 under AM 1.5G, simulated light surpasses commercial Pt/C catalysts. High IP pollutants enhance hydrogen evolution rates, indicating a synergistic effect. Theoretical calculations elucidated the interplay between seawater electrolytes and high IP values on the photoelectrocatalytic performance. Ni-Mn@OBN demonstrated excellent stability and a solar-to-hydrogen (STH) efficiency of 3.72%, offering a sustainable solution for marine pollution control and clean energy production.}, archive = {J_ANGEW}, author = {Xudong Hu and Shuo Cheng and Usman Farooq and Izaz Ul islam and Xinhai Wang}, doi = {10.1002/anie.202505094}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505094}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Theory-guided design of surface-enhanced Ni–Mn diatomic site catalysts for efficient seawater electrolysis via the degradation of high ionization potential organic pollutants}, volume = {64}, year = {2025}, }
• (2025). An immediate bacterial-responsive supramolecular thio-naphthalene diimide: A real-time NIR-II photothermal anti-bacterial. ANGEW, 64(24), e202505069. (www)

  @article{ , abstract = {A new kind of supramolecular thio-naphthalene diimide (SNDI) which can be immediately reduced as supramolecular radical anion by bacteria is reported. The introduction of thiocarbonyl effectively elevates the reduction potential of SNDI, largely increasing the bacteria-response speed in hypoxia. It selectively distinguishes the bacteria with high and low reduction ability in real time. The host–guest complexation of SNDI and cucurbit[7]uril can enhance radical anion quantum yield, ensuring intense NIR-II absorption and realizing high photothermal conversion. The real-time NIR-II photothermal anti-bacteria is successfully carried out. This development will enrich the design of bio-responsive agent with promising future towards actual application.}, archive = {J_ANGEW}, author = {He Ma and Yushen Kang and Weiquan Xu and Yuanchen Shen and Huacheng Yu and Hao Hu and Xingchen Tang and Jiang-Fei Xu and Xi Zhang}, doi = {10.1002/anie.202505069}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An immediate bacterial-responsive supramolecular thio-naphthalene diimide: A real-time NIR-II photothermal anti-bacterial}, volume = {64}, year = {2025}, }
• (2025). Ionized water facilitates the sustainable radical-mediated reduction of CO2 to multi-carbon hydrocarbons and oxygenates. ANGEW, 64(24), e202505042. (www)

  @article{ , abstract = {The abiotic synthesis of organic compounds from CO 2 and water under prebiotic conditions is a fundamental yet unresolved challenge in understanding the origins of life. Here we demonstrate a radical-mediated pathway for reducing CO 2 to C 1 ‒C 6 hydrocarbons and oxygenates driven solely by ultraviolet (UV) irradiation of water, mimicking early Earth environments. Using electron paramagnetic resonance (EPR), 17 O/ 13 C isotope labeling, and femtosecond transient absorption, we identify ionized water-derived radicals (H 2 O •+ , • OH, e⁻ aq , • H) as the key redox mediators. e⁻ aq acts as a super-reductant (−2.9 V) to activate CO 2 into CO 2 • ⁻, while • H enables sequential hydrogenation. Critically, oxidative radicals (H 2 O •+ and • OH) recycle recalcitrant oxygenates (formate and oxalate) back into active CO 2 • ⁻, sustaining a dynamic radical network. This process generates a diverse library of organic compounds, including methane, ethylene, and C 6 dimethyl succinate, via radical assembly mechanisms spanning hydrogen-atom transfer (HAT), self-coupling, and cross-coupling. By integrating experimental validation with prebiotic simulations (formate-mediated redox modulation), we resolve the paradox of inert CO 2 /H 2 activation in primordial environments and establish water not merely as a solvent but as a reactive matrix directing abiotic organic synthesis.}, archive = {J_ANGEW}, author = {Lei Li and Chunhua Cui}, doi = {10.1002/anie.202505042}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505042}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ionized water facilitates the sustainable radical-mediated reduction of CO2 to multi-carbon hydrocarbons and oxygenates}, volume = {64}, year = {2025}, }
• (2025). Site-selective carbonylation of azetidines via copper-catalyzed difluorocarbene insertion. ANGEW, 64(24), e202505033. (www)

  @article{ , abstract = {γ-Lactams are privileged five-membered pharmaco-phores in numerous bioactive compounds, but access to these motifs typically relies on cycloaddition/substitution chemistry involving activated substrates or CO carbonylations under harsh conditions. Here, we report a new route to functionalized γ-lactams through formal carbonylation of azetidines under nonprecious metal catalysis. The method leverages a copper-stabilized difluorocarbene to promote site-selective insertion followed by in situ hydrolysis to unmask the lactam group. In contrast to most difluorocarbene reactions that cause ring cleavage of saturated heterocycles in the presence of heat, the present system operates at a low temperature and retains the integrity of the cyclic structure. Synthesis of various drug-like lactams and a therapeutic agent for diabetes highlights utility.}, archive = {J_ANGEW}, author = {Fang Zhou and Tong-De Tan and Ming Joo Koh}, doi = {10.1002/anie.202505033}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202505033}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-selective carbonylation of azetidines via copper-catalyzed difluorocarbene insertion}, volume = {64}, year = {2025}, }
• (2025). Structural basis of sequential enantioselective epoxidation by a flavin-dependent monooxygenase in lasalocid a biosynthesis. ANGEW, 64(24), e202504982. (www)

  @article{ , abstract = {Polyether polyketides are a structurally diverse group of natural products known for their antimicrobial and antiproliferative activities. Lasalocid A is a canonical natural polyether produced by the soil bacterium Streptomyces lasalocidi . In lasalocid A biosynthesis, a polyene polyketide intermediate is converted into a bisepoxide by the flavin-dependent monooxygenase enzyme Lsd18. Remarkably, Lsd18 acts on two distinct C═C groups in the substrate molecule, forming two ( R , R ) epoxides. We have determined the X-ray crystal structures of Lsd18 in the substrate-free, substrate-bound, and product-bound forms. Our work has revealed that Lsd18 has an extra-large substrate-binding pocket that allows the polyene to adopt different conformations within the enzyme pocket. This feature enables Lsd18 to epoxidate both of the C═C groups. Additionally, a subpocket located near the Lsd18 active site controls stereoselectivity by dictating which face of the C═C group is placed next to the flavin. Molecular understanding of how Lsd18 transforms a polyene into a bisepoxide during lasalocid A biosynthesis lays the foundation for the production of designer polyethers for drug development.}, archive = {J_ANGEW}, author = {Qian Wang and Yaming Deng and Dayan Viera and Xiaopeng Liu and Ning Liu and Yulu Hu and Xiangdong Hu and Hao Wei and Quan Zhou and Ting Lan and Wei He and Xi Chen and Chu-Young Kim}, doi = {10.1002/anie.202504982}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504982}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural basis of sequential enantioselective epoxidation by a flavin-dependent monooxygenase in lasalocid a biosynthesis}, volume = {64}, year = {2025}, }
• (2025). Switchable closed-shell and open-shell biradical states in bis-palladium complexes of tetrathiadodecaphyrin via coordination rearrangement. ANGEW, 64(24), e202504774. (www)

  @article{ , abstract = {A figure-eight tetrathiadodecaphyrin ( 1 ), featuring two porphyrin-like sub-pockets separated by central carbazolylenes was synthesized. Metalation of the thiaporphyrinoid ligand with Pd(OAc) 2 produces two distinct bis-Pd(II) complexes with different coordination environments. Complex 2 , adopting an {NNCS} metalation mode, exhibits a closed-shell electronic structure, whereas complex 3 , with an {NNCC} coordination environment, exists as a ligand-centered organic biradicaloid with two magnetically independent spins ( S = 1/2). Biradical formation is attributed to single-electron transfer from each ligand sub-pocket to the Pd(II) center accommodated in a d 8 square-planner coordination geometry. Notably, the complexes are interconvertible through doubly one-electron redox processes, demonstrating a reversible metal coordination rearrangement via thiophene ring flipping within a porphyrinoid framework. This work establishes the first example of such tunable metal coordination, offering a precise strategy for modulating closed-shell and open-shell biradical states. In addition, while complex 2 displays intense absorption and photoacoustic responses to the first near-infrared (NIR-I) light in water after encapsulation within nanoparticles, the nanocomposites encapsulating biradicaloid 3 exhibits enhanced responsiveness in the second near-infrared (NIR-II) region.}, archive = {J_ANGEW}, author = {Chengming Li and Linfeng He and Gang Xu and Yongjie Zhou and Qiong Wu and Kaizhi Li and Jiayin Yang and Zhen Shen and Jingsong You}, doi = {10.1002/anie.202504774}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504774}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switchable closed-shell and open-shell biradical states in bis-palladium complexes of tetrathiadodecaphyrin via coordination rearrangement}, volume = {64}, year = {2025}, }
• (2025). Self-compartmented electrolyte design for stable cycling of lithium metal batteries under extreme conditions. ANGEW, 64(24), e202504632. (www)

  @article{ , abstract = {Electrolyte is the key component dictating lithium battery performance, especially under extreme conditions such as fast cycling and low temperatures. However, conventional electrolyte design principles, which generally rely on a homogeneous mixture of solvents, salts, and functional additives, fail to simultaneously meet the requirements for both anodic/cathodic interfacial stability and bulk ion-transport kinetics in lithium metal batteries. Herein, we present a self-compartmented electrolyte design methodology. Lithium 4,5-dicyano-2-(trifluoromethyl)imidazol-1-ide (LiTDI), featuring the ability to selectively self-assemble on the cathode/electrolyte interface, compartmented the electrolyte into a heterogonous one. Close to the cathode side, LiTDI could induce an interfacial high-concentration region, where the anion-rich solvation structure facilitates the formation of a stable cathode–electrolyte interphase (CEI). In the bulk, the electrolyte maintains a low concentration with low viscosity, ensuring fast ion transport and superior rate performance. Li||NCM811 cells achieve over 500 stable cycles with 80.3% capacity retention and deliver 169.3 mAh g −1 at a 10C discharge rate. Under low-temperature conditions (−20 °C), the cells maintained outstanding stability over 700 cycles at 0.5C charge/discharge, achieving capacity retention of 96.6% and an average Coulombic efficiency of 99.2%. This work provides a new electrolyte design paradigm, addressing the critical challenges of LMBs for high-voltage and low-temperature applications.}, archive = {J_ANGEW}, author = {Yu Ou and Da Zhu and Pan Zhou and Changjian Li and Yang Lu and Qingbin Cao and Xuan Song and Wenhui Hou and Shuaishuai Yan and Yingchun Xia and Hangyu Zhou and Weili Zhang and Qingqing Feng and Hong Xu and Kai Liu}, doi = {10.1002/anie.202504632}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504632}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-compartmented electrolyte design for stable cycling of lithium metal batteries under extreme conditions}, volume = {64}, year = {2025}, }
• (2025). ATP-assisted electron and proton transfer boosting redox metabolism-induced ferroptosis and apoptosis for cancer therapy. ANGEW, 64(24), e202504542. (www)

  @article{ , abstract = {Compared to the intractability of traditional apoptosis, the vulnerability exposed by cancer cell metabolic reprogramming provides an advantage for ferroptosis treatment. Herein, we developed vanadate and aurintricarboxylic acid coordination nanoparticles (VAP NPs) that synergistically trigger dual cell death pathways. This nanoplatform leveraged dual-Russell mechanisms and Fenton reactions to generate singlet oxygen/hydroxyl radicals in the tumor microenvironment (TME) while depleting glutathione via vanadium redox cycling, thereby silencing glutathione peroxidase 4 and modulating the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase 1 (HMOX1) axis. Notably, TME-overexpressed adenosine triphosphate (ATP) acted as a biochemical catalyst, accelerating the transfer of protons and electrons during reactive oxygen species generation to amplify therapeutic efficacy. Therefore, VAP NPs could achieve outstanding efficacy for intrinsically stimulated synergy of ferroptosis and apoptosis in tumor therapy. This study provides reference for revealing the new function of ATP in enhancing the regulation of redox metabolism.}, archive = {J_ANGEW}, author = {Shangjie An and Wenyao Zhen and Yue Wang and Xiaodan Jia and Xiue Jiang}, doi = {10.1002/anie.202504542}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504542}, shortjournal = {Angew. Chem. Int. Edit.}, title = {ATP-assisted electron and proton transfer boosting redox metabolism-induced ferroptosis and apoptosis for cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Mechanistic insights into the CO2-assisted NO electrochemical deoxygenation and hydrogenation. ANGEW, 64(24), e202504499. (www)

  @article{ , abstract = {Electrocatalytic NO reduction to NH 3 holds significant potential for pollutant treatment and resource recovery. Herein, we report that the introduction of CO 2 on octahedral oxide-derived copper (o-OD-Cu) significantly enhances the electrochemical reduction of NO to NH 3 . With 10% NO in a CO 2 environment, the Faradaic efficiency for NH 3 production in a flow cell remains around 80% over a wide current density range from 20 to 250 mA cm −2 . At a current density of 250 mA cm −2 , the yield can reach up to 1403.9 µmol cm −2 h −1 , which is 3.71 times higher than without CO 2 and surpasses the performance reported in similar literature. Moreover, even at a low concentration of 1% NO, the Faradaic efficiency can reach a maximum of 70.11% at a current density of 20 mA cm −2 . In situ investigations and theoretical calculations revealed that, in the coexistence of NO and CO 2 , the NO reduction pathway involves a unique route wherein *CO and *COOH, produced from CO 2 reduction, can respectively promote the deoxygenation of *NO and hydrogenation of *N by acquiring O atoms from *NO and providing H atoms for the sustained hydrogenation of *N, thereby accelerating the conversion process of NO to NH 3 .}, archive = {J_ANGEW}, author = {Pan Li and Yi Liu and Liangyiqun Xie and Guangtao Wang and Xuanzhao Lu and Jian Li and Xuanhao Wu and Yujing Jiang and Wenlei Zhu}, doi = {10.1002/anie.202504499}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504499}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanistic insights into the CO2-assisted NO electrochemical deoxygenation and hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Ligand-controlled regiodivergent carbosilylation of 1,3-dienes via nickel-catalyzed three-component coupling reactions. ANGEW, 64(24), e202504494. (www)

  @article{ , abstract = {The regiodivergent carbosilylation of 1,3-dienes presents a formidable challenge due to inherently complex selectivity control over multiple potential reaction pathways. Here, we report a ligand-controlled, regiodivergent carbosilylation of 1,3-dienes with aldehydes and silylboranes, achieving unprecedented site-selectivity using nickel catalysts with distinct phosphine ligands. The use of triethylphosphine promotes 4,3-addition selectivity, while employing (2-biphenyl)dicyclohexylphosphine facilitates 4,1-addition selectivity. This method displays excellent regio- and diastereoselectivity, as well as a broad substrate scope and substantial functional group tolerance. Mechanistic studies indicate that the ligand choice is crucial for directing the reaction pathway and stabilizing π-allyl-nickel intermediates. Our protocol provides a practical and efficient approach to synthesizing valuable functionalized allylsilanes, which are important in various synthetic applications.}, archive = {J_ANGEW}, author = {Shan Jiang and Tianze Zhang and Xiao-Yuan Luo and Shoucheng Dong and Jin-Tao Ma and Li-Jun Xiao}, doi = {10.1002/anie.202504494}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504494}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-controlled regiodivergent carbosilylation of 1,3-dienes via nickel-catalyzed three-component coupling reactions}, volume = {64}, year = {2025}, }
• (2025). Electrochemical amination of aryl halides with NH3. ANGEW, 64(24), e202504459. (www)

  @article{ , abstract = {Primary arylamines are the most pivotal class of organic motifs in pharmaceuticals, agrochemicals, ligands and natural products. Ammonia (NH 3 ) is an ideal nitrogen source in terms of reactivity, atom economy, and environmental compatibility. Despite significant progress in the synthesis of primary arylamines, the development of a general method for rapid access to diversely functionalized primary arylamines is still urgent and necessary. Herein, we developed a method for the direct synthesis of primary arylamines through electrochemical amination of aryl halides with NH 3 . Notably, the weak nucleophilic reagent NH 3 was directly used as an ammonia surrogate, allowing for efficient conversion of carbon-halogen bonds to diverse primary arylamines with good functional group tolerance. A broad scope of functionalized primary arylamines has been achieved in moderate to excellent yields.}, archive = {J_ANGEW}, author = {Yaowen Liu and Yanfei Sun and Yuan Deng and Youai Qiu}, doi = {10.1002/anie.202504459}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical amination of aryl halides with NH3}, volume = {64}, year = {2025}, }
• (2025). Synthesis of chiral δ-aminoboronic esters by enantioselective hydrogenation of 1,2-azaborines. ANGEW, 64(24), e202504419. (www)

  @article{ , abstract = {We describe herein an iridium-catalyzed highly diastereo- and enantioselective hydrogenation of 1,2-azaborines to access δ-aminoboronic esters of potential biological importance. This method represents the first enantioselective hydrogenation of a boron-containing heteroarene and features diverse substitution patterns and wide scope. The synthetic utility of our method was demonstrated by the synthesis of (−)-phenibut and the formal synthesis of (+)-3-PPP and fluvirucinine A 1 .}, archive = {J_ANGEW}, author = {Jiangpeng Liu and Yuping Dai and Devon Robinson and Bo Li and Karinne Miqueu and Shih-Yuan Liu}, doi = {10.1002/anie.202504419}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504419}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of chiral δ-aminoboronic esters by enantioselective hydrogenation of 1,2-azaborines}, volume = {64}, year = {2025}, }
• (2025). Enhanced luminance of pentaazaphenalene-based delayed fluorescence emitters by breaking forbidden transition. ANGEW, 64(24), e202504390. (www)

  @article{ , abstract = {1,3,4,6,9 b -pentaazaphenalene (5AP) derivatives are of growing interest because of their potential for exhibiting thermally activated delayed fluorescence and inverted singlet–triplet excited state properties. However, a major challenge has been the nonemissive nature of 5AP. This study reports a donor-5AP-acceptor-type molecular design for converting nonemissive 5AP into highly emissive molecules. The newly designed molecules, 2,5-di(1-pyrrolidino)-7,9-bis(4-(trifluoromethyl)phenyl)-1,3,4,6,9 b -pentaazaphenalene ( Pyr-5AP-CF 3 ) and 2,5-di(1-pyrrolidino)-7,9-bis(4-benzonitrile)-1,3,4,6,9 b -pentaazaphenalene ( Pyr-5AP-CN ), exhibited delayed fluorescence and achieved high photoluminescence quantum yields of 83.5% and 90.6%, respectively, in solid films. These values dramatically exceed those of previously reported 5AP derivatives with only 8% or less. Furthermore, Pyr-5AP-CF 3 and Pyr-5AP-CN exhibited the fastest radiative decays and the narrowest emission spectra among all the 5AP based materials reported to date. This study provides a promising solution to the nonemissive nature of 5AP, leading to the development of a class of highly luminescent materials for future organic light-emitting diodes.}, archive = {J_ANGEW}, author = {Yuka Yasuda and Katsuyuki Shizu and Hiroyuki Tanaka and Hironori Kaji}, doi = {10.1002/anie.202504390}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced luminance of pentaazaphenalene-based delayed fluorescence emitters by breaking forbidden transition}, volume = {64}, year = {2025}, }
• (2025). Cobalt-metalated 1D perylene diimide carbon-organic framework for enhanced photocatalytic α-C(sp3)─H activation and CO2 reduction. ANGEW, 64(24), e202504348. (www)

  @article{ , abstract = {The photocatalytic activation of inert C(sp 3 )─H bonds in saturated aza -heterocycles provides a direct and efficient route to high-value α-amino amides but remains challenging due to intrinsically high bond dissociation energies. Herein, we report a cobalt-metalated, one-dimensional ABC-stacking covalent organic framework ( PP-COF-Co ), integrating perylene diimide (PDI) as a photosensitizer and 1,10-phenanthroline as a metal coordination site. Cobalt metalation significantly enhances photocatalytic efficiency, enabling the α -C(sp 3 )─H carbamoylation of saturated aza -heterocycles with yields of up to 91%, far surpassing its non-metalated counterpart (59%). This enhancement arises from the synergistic interplay between the PDI units and cobalt centers, which promote electron-hole pair separation and enhance singlet oxygen ( 1 O 2 ) generation. Moreover, PP-COF-Co exhibits a 57-fold increase in photocatalytic CO 2 reduction activity compared to its pristine analogue. This work highlights the critical role of metalation in modulating charge dynamics within COF-based photocatalysts and offers insights into the development of next-generation materials for sustainable catalysis.}, archive = {J_ANGEW}, author = {Chao Zhu and Chengtao Gong and Duojun Cao and Li-Li Ma and Dongdong Liu and Liyan Zhang and Yang Li and Yongwu Peng and Guozan Yuan}, doi = {10.1002/anie.202504348}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-metalated 1D perylene diimide carbon-organic framework for enhanced photocatalytic α-C(sp3)─H activation and CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). A Donor–Acceptor-type two-dimensional Poly(Arylene vinylene) for efficient electron transport and sensitive chemiresistors. ANGEW, 64(24), e202504302. (www)

  @article{ , abstract = {Two-dimensional (2D) conjugated polymers and their layer-stacked 2D conjugated covalent organic frameworks, such as 2D poly(arylene vinylene)s (2D PAVs), are emerging as promising polymer semiconductors for electronics and photocatalysis. However, achieving narrow optical band gaps and efficient electron transport remains a significant challenge for this class of materials to enhance the device's performance. Here, we report a donor-acceptor-type 2D PAV ( 2DPAV-TBDT-IT , where TBDT = thienyl-benzodithiophene and IT = s -indacene-1,3,5,7(2 H ,6 H )-tetraone) synthesized via an Aldol-type 2D polycondensation approach. Notably, 2DPAV-TBDT-IT benefits from an effective intralayer donor–acceptor effect, exhibiting an optical band gap of 1.15 eV, the smallest among the reported 2D conjugated polymers. Density functional theory calculations reveal a unique electron-dominating transport for 2DPAV-TBDT-IT , with a strongly dispersive conduction band minimum and, thus, a small effective mass for electrons half that for holes. Additionally, terahertz spectroscopy measurements indicate a high charge mobility of 26 cm 2 V −1 s −1 at room temperature for the powder sample. Given the high electron-deficiency of 2DPAV-TBDT-IT for facile electron injection from hazardous gases and the high-mobility electron-dominating transport in the material, we further fabricate chemiresistors from 2DPAV-TBDT-IT , showing ultrasensitive SO 2 analyte detection with limit of detection of 0.088 ppb, significantly surpassing the reported chemiresistive SO 2 sensors.}, archive = {J_ANGEW}, author = {Ruyan Zhao and Wei Wang and Yamei Liu and Petko Petkov and Arafat Hossain Khan and Lei Gao and Peng Zhang and Eike Brunner and Hai I. Wang and Shivam Singh and Shirong Huang and Luis Antonio Panes-Ruiz and Yana Vaynzof and Mischa Bonn and Gianaurelio Cuniberti and Mingchao Wang and Xinliang Feng}, doi = {10.1002/anie.202504302}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504302}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A Donor–Acceptor-type two-dimensional Poly(Arylene vinylene) for efficient electron transport and sensitive chemiresistors}, volume = {64}, year = {2025}, }
• (2025). Entropy-driven competitive adsorption sites tailoring unlocks efficient hybrid conversion Zn–Air batteries. ANGEW, 64(24), e202504188. (www)

  @article{ , abstract = {Hybrid conversion Zn–air batteries (HC-ZABs) epitomize a typical integrated energy storage and conversion device that advances green chemistry and reduces carbon emissions. However, balancing efficiency and selectivity of electrocatalytic cathodic reactions remains the bottleneck in such batteries. Herein, we address this issue by designing a high-entropy perovskite, La 0.6 Sr 0.1 Ca 0.1 Rb 0.1 Y 0.1 CoO 3 (HE-LCO), which outperforms conventional perovskites in offering enhanced electrocatalytic activity, better selectivity, and outstanding stability for cathodic benzyl alcohol oxidation reaction (BAOR). Combined spectroscopy characterizations, operando measurements, and theoretic calculations reveal that the entropy-driven modulation of the second coordination sphere in HE-LCO balances the adsorption of nucleophile benzyl alcohol and OH − , while inhibiting competing oxygen evolution reaction (OER). Based on this rationalized HE-LCO electrocatalyst, HC-ZABs realized efficient energy storage and benzoic acid production, boasting a long lifespan of 900 cycles at 20 mA cm −2 and 6.7 mAh cm −2 per cycle. Further, practical ampere-hour-scale HC-ZABs demonstrated a 62.8% energy efficiency improvement and an average benzoic acid yield of 0.85 g per cycle, highlighting the potential of this integrated device for simultaneous sustainable energy storage and green electrochemical synthesis.}, archive = {J_ANGEW}, author = {Pengyang Jiang and Yan Xu and Zhe Gong and Baoxin Ge and Luyao Ding and Caijin Huang and Xiaoqing Qiu and Zengxia Pei}, doi = {10.1002/anie.202504188}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Entropy-driven competitive adsorption sites tailoring unlocks efficient hybrid conversion Zn–Air batteries}, volume = {64}, year = {2025}, }
• (2025). Vacancy and dopant co-constructed active microregion in Ru–MoO3−x/Mo2AlB2 for enhanced acidic hydrogen evolution. ANGEW, 64(24), e202504084. (www)

  @article{ , abstract = {Accurate identification of catalytic active regions is crucial for the rational design and construction of hydrogen evolution catalysts as well as the targeted regulation of their catalytic performance. Herein, the low crystalline-crystalline hybrid MoO 3− x /Mo 2 AlB 2 with unsaturated coordination and rich defects is taken as the precursor. Through the Joule heating reaction, the Ru-doped MoO 3− x /Mo 2 AlB 2 catalyst is successfully constructed. Building on the traditional view that individual atoms or vacancies act as active sites, this article innovatively proposes the theory that vacancies and doped atoms synergistically construct active microregions, and multiple electron-rich O atoms within the active microregions jointly serve as hydrogen evolution active sites. Based on X-ray absorption fine structure analysis and first-principles calculations, there is a strong electron transfer among Ru atoms, Mo atoms, and O atoms, leading to extensive O atoms with optimized electronic structure in the active microregions. These O atoms exhibit an H * adsorption free energy close to zero, thereby enhancing the catalytic activity for hydrogen evolution. This work provides a brand-new strategy for the design and preparation of electrocatalytic materials and the systematic regulation of the local electronic structure of catalysts.}, archive = {J_ANGEW}, author = {Yuquan Yang and Dawei Pang and Chenjing Wang and Zhongheng Fu and Naiyan Liu and Jiajia Liu and Hongjing Wu and Binbin Jia and Zhonglu Guo and Xiaoyu Fan and Jinlong Zheng}, doi = {10.1002/anie.202504084}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202504084}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vacancy and dopant co-constructed active microregion in Ru–MoO3−x/Mo2AlB2 for enhanced acidic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). DNA-based signal circuit for self-regulated bidirectional communication in protocell-living cell communities. ANGEW, 64(24), e202503903. (www)

  @article{ , abstract = {Developing synthetic biology tools to control cell-to-cell signaling can provide new capabilities to engineer cell-cell communication and program desired cellular behaviors. As cell mimics, abiotic protocells provide an attractive opportunity to modulate the intercellular communication with design-based regulatory features. Despite the chemical communication of protocells that interact with living cells have been demonstrated, the autonomous regulation of intercellular signal transmission in protocell/living cell community remains a critical challenge. Herein, we designed a DNA circuit consisting of a recognition module, activation module, and feedback module that enables protocells to self-regulate the interaction with living cells by sensing and responding to the signal released from living cells. The feedback module with renewable capability is capable of processing the signal transduction on the membrane surface of protocells and controlling intercellular adhesion. Once dissociated from living cells, the disengaged protocells allow the following interaction with multiple target living cells in succession. Overall, this work provides an avenue to control and program dynamic signal propagation in protocell/living cell community. The designed communication with living cells would open new ways to tune cellular behavior and apply them to cell-based therapeutics.}, archive = {J_ANGEW}, author = {Lexun Li and Shuang Liu and Chundi Zhu and Shuxuan Shao and Fan Yang and Qiaoling Liu and Weihong Tan}, doi = {10.1002/anie.202503903}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503903}, shortjournal = {Angew. Chem. Int. Edit.}, title = {DNA-based signal circuit for self-regulated bidirectional communication in protocell-living cell communities}, volume = {64}, year = {2025}, }
• (2025). N-(Acyldithio)Saccharin: Design, synthesis and applications in catalytic enantioselective Disulfuration/Amination of alkenes. ANGEW, 64(24), e202503815. (www)

  @article{ , abstract = {We have designed and successfully synthesized N -(acyldithio)saccharin, which is a highly electrophilic, bench-stable, and user-friendly disulfurating reagent. This reagent can undergo reactions with diverse N-, S-, and C-nucleophiles at room temperature. In most cases, no additional catalyst is required, and the desired disulfides were readily obtained in moderate to excellent yields. With this reagent, late-stage disulfuration of pharmaceuticals and biomolecules was readily accomplished. For the first time, catalytic enantioselective disulfuration/amination of unactivated alkenes was achieved using this reagent. A series of chiral disulfides were obtained with high enantioselectivities and yields. The chiral disulfide products can be readily further transformed into chiral sulfonyl fluoride, chiral thiol, and structurally diverse disulfide products. Furthermore, we have evaluated the electrophilic reactivity of a series of disulfurating reagents based on density functional theory calculations, verifying the high reactivity of N -(acyldithio)saccharin both experimentally and theoretically.}, archive = {J_ANGEW}, author = {Yu-Xuan Huo and Ren-Fei Cao and Jie Huang and Ze-Long Li and Zheng-Wei Wei and Deng Zhu and Zhi-Min Chen}, doi = {10.1002/anie.202503815}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503815}, shortjournal = {Angew. Chem. Int. Edit.}, title = {N-(Acyldithio)Saccharin: Design, synthesis and applications in catalytic enantioselective Disulfuration/Amination of alkenes}, volume = {64}, year = {2025}, }
• (2025). Optimizing the selectivity of CH4 electrosynthesis from CO2 over cuprates through Cu─O bond length descriptor. ANGEW, 64(24), e202503745. (www)

  @article{ , abstract = {Precisely controlling the nature of Cu─O bond in Cu-based oxide catalysts and understanding its correlation with CH 4 electrosynthesis (from CO 2 ) for selectivity optimization is a long-standing challenge. Herein, taking a specific type of cuprates structured with CuO 4 square-planar motifs as the platform, we report a selectivity descriptor of Cu─O bond length for screening highly selective catalysts toward CH 4 electrosynthesis. We establish the descriptor by systematic investigations of several proof-of-concept cuprates. Their Cu─O bond lengths are precisely controlled ranging from 1.944 to 1.970 Å and these bonds remain stable in CH 4 selectivity evaluation. Our investigations demonstrate that the CH 4 selectivity exhibits a volcano-type dependence on the Cu─O bond length, and the optimized value is accessible at about 1.951 Å. This could be attributed to the optimal (neither too strong nor too weak) *CO adsorption created by the moderate Cu─O bond length, facilitating *CO hydrogenation. Furthermore, utilizing this descriptor, we predict three highly selective cuprates for CH 4 electrosynthesis, with superior selectivity that is near the top of the volcano plot. And importantly, in an acidic electrolyte (pH = 1), they outperform the reported catalysts, achieving CH 4 selectivity of up to 61.7% at 300 mA cm −2 .}, archive = {J_ANGEW}, author = {Yunze Xu and Yu Zhang and Hongyan Zhao and Lei Shi and Zhenbao Zhang and Xueyan Li and Zhen Xue and Heqing Jiang and Yongfa Zhu and Jiawei Zhu}, doi = {10.1002/anie.202503745}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503745}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimizing the selectivity of CH4 electrosynthesis from CO2 over cuprates through Cu─O bond length descriptor}, volume = {64}, year = {2025}, }
• (2025). Bioinspired cationic antimicrobial polymers. ANGEW, 64(24), e202503738. (www)

  @article{ , abstract = {Antibiotics are an essential tool of modern medicine, which is critically endangered by the spread of antimicrobial resistance (AMR). Without effective antibiotics, a number of medical advancements from the last century are in jeopardy, threatening our global public health and leading to a high death toll. To counteract this development, new therapeutic strategies, that are insusceptible to resistance development have to be established. Among them, antimicrobial polymers (AP)s are a promising class of materials. Their mode-of-action is highly unspecific as they kill bacteria by membrane permeabilization or precipitation of intracellular components. As such, it is unlikely for APs to be affected by AMR. This review highlights recent advances in AP design and understanding of structure–property relationships of these cationic macromolecules. One spotlight is on the polymeric architecture and how it influences AP bioactivity. A second highlight is stimuli-responsive APs and their potential to increase AP selectivity. Moreover, synergistic effects, e.g., between polymer and antibiotics are reviewed. The last focus is on in vivo applications of APs, which could pave a way toward clinical applications.}, archive = {J_ANGEW}, author = {Heliya Javadi and Anne-Catherine Lehnen and Matthias Hartlieb}, doi = {10.1002/anie.202503738}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503738}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bioinspired cationic antimicrobial polymers}, volume = {64}, year = {2025}, }
• (2025). Discovery and biosynthesis of celluxanthenes, antibacterial arylpolyene alkaloids from diverse cellulose-degrading anaerobic bacteria. ANGEW, 64(24), e202503697. (www)

  @article{ , abstract = {Cellulose degradation by anaerobic bacteria plays an eminent role in the global carbon cycle and is a critical step in biofuel production. The anaerobic thermophile Clostridium thermocellum (now: Acetivibrio thermocellus ) is particularly efficient at breaking down biomass and produces a “yellow affinity substance” (YAS), a pigment that has been implicated in signaling and conferring higher affinity of the cellulosome to YAS-loaded cellulose. However, the nature and biosynthetic origin of YAS have remained elusive. Here, we show by isolation and structure elucidation that YAS is a complex of unusual arylpolyene alkaloids (celluxanthenes). Stable isotope labeling experiments reveal all biosynthetic building blocks for celluxanthene assembly. Through a targeted gene deletion, we identify the celluxanthene ( cex ) biosynthesis gene cluster and propose a biosynthetic model in which an arylpolyene generated by an iterative type I polyketide synthase (PKS) undergoes a head-to-head fusion with a tryptophan-derived ketoacid to form a tetronate. Genome mining and metabolic profiling revealed that diverse cellulolytic anaerobes harbor cex gene loci and produce celluxanthene congeners. Celluxanthenes show antibiotic activity against Gram-positive bacteria including clinically relevant strains. This study solves the long-standing enigma surrounding the nature of YAS and lays the groundwork for elucidating the precise biological roles of these intricate pigments.}, archive = {J_ANGEW}, author = {Keishi Ishida and Jana Krabbe and Philippe R. Meisinger and Gulimila Shabuer and Sebastian Schieferdecker and Michael Cyrulies and Cedric Tank and Emma Barnes and Christian Paetz and Christian Hertweck}, doi = {10.1002/anie.202503697}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503697}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Discovery and biosynthesis of celluxanthenes, antibacterial arylpolyene alkaloids from diverse cellulose-degrading anaerobic bacteria}, volume = {64}, year = {2025}, }
• (2025). A 3D hybrid perovskite ferroelastic with triclinic-to-cubic phase transition boosts Temperature/Pressure dual On/Off switchable birefringence. ANGEW, 64(24), e202503681. (www)

  @article{ , abstract = {Birefringent crystals have gained enormous attention for decades due to their unique ability to manipulate polarized light. However, achieving the fascinating on/off (active/inactive) switchable birefringence under external stimuli in crystals remains a huge challenge, and the stimuli employed have been constrained predominantly to temperature. Here, through H/F substitution, we designed a 3D hybrid double perovskite ferroelastic [C 3 H 5 FNH 2 ] 2 [(NH 4 )Fe(CN) 6 ] ( 1-F ), which undergoes a ferroelastic transition at 296 K, with the highest possible orientation states of 24 among ferroelastic crystals. Notably, the ferroelastic phase transition of 1-F can also be triggered by pressure with a low critical pressure of ∼0.3 GPa. More importantly, 1-F shows the unprecedented temperature/pressure dual stimuli-induced on/off switching of birefringence between the birefringence-active state in the anisotropic triclinic ferroelastic phase and the birefringence-inactive state in the isotropic cubic paraelastic phase during the ferroelastic transition. To the best of our knowledge, this is the first report of dual stimuli-induced switchable birefringence in crystals. Our work paves a new way for the switching of birefringence and sheds light on the further exploration of switchable birefringence in ferroelastics.}, archive = {J_ANGEW}, author = {Huan-Huan Chen and Xiao-Gang Chen and Zhe-Kun Xu and Hang Peng and Yan Qin and Hui-Peng Lv and Xian-Jiang Song and Sheng-Qian Hu and Luan-Ying Ji and Jun-Si Zhou and Ren-Gen Xiong and Wei-Qiang Liao}, doi = {10.1002/anie.202503681}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503681}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A 3D hybrid perovskite ferroelastic with triclinic-to-cubic phase transition boosts Temperature/Pressure dual On/Off switchable birefringence}, volume = {64}, year = {2025}, }
• (2025). A powerful regulator to enhance electrocatalytic reaction kinetics and thermodynamics: The ordered hetero-nanowire. ANGEW, 64(24), e202503613. (www)

  @article{ , abstract = {Optimizing the thermodynamics of electrode reactions is a valid strategy for achieving superior electrocatalysts for direct methanol fuel cells (DMFCs). However, as the catalyst downsizes to the nanoscale, the influence of mass transfer kinetics is pronounced in improving electrocatalytic activity. Herein, an ordered hetero-nanowire (NW) regulator that couples the virtues of kinetics and thermodynamics is reported. Finite element analysis demonstrates that the periodic arrangement of hetero-NWs could construct a uniform electric field, promoting the precise mass transfer of reactant molecules and accelerating the electrode reaction kinetics for the methanol oxidation reaction (MOR). In addition, the microscopic electronic structure effect of the well-defined catalyst weakens the bonding interaction toward toxic carbonaceous intermediates, which meanwhile strengthens the adsorption of hydroxyl species, critically contributing to enhanced MOR durability. The wide generality of this regulator has been confirmed by a series of as-prepared ordered hetero-NW catalysts, which show prominent electrocatalytic performance, including relatively high mass activity, superior CO resistance, and long-term stability. Therefore, this work reveals the importance of the tandem effect of kinetics and thermodynamics in electrocatalysis, which provides valuable insights for developing customized and highly efficient catalysts for extensive applications.}, archive = {J_ANGEW}, author = {Tian Liu and Zhen He and Jin-Long Wang and Si-Zhe Sheng and Zhi-Yu Xian and Jian-Wei Liu and Shu-Hong Yu}, doi = {10.1002/anie.202503613}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503613}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A powerful regulator to enhance electrocatalytic reaction kinetics and thermodynamics: The ordered hetero-nanowire}, volume = {64}, year = {2025}, }
• (2025). Hopping diffusion in wiggling nanopore architecture of MOF enabling synergistic equilibrium-kinetic separation of fluorinated propylene and propane. ANGEW, 64(24), e202503505. (www)

  @article{ , abstract = {The separation of octafluoropropane (C 3 F 8 ) from hexafluoropropylene (C 3 F 6 ) is an industrially important yet challenging process due to their similar physicochemical properties and stringent purity demands in industrial applications. Herein, we address this task through precise pore architecture in a zirconium-based metal-organic framework (Zr-PMA), which exhibits unique “wiggling nanopores” with narrow windows and large cavities. The narrow windows act as diffusion barriers, selectively restricting C 3 F 8 transport, while the large cavities provide strong adsorption sites for C 3 F 6 , enabling an equilibrium-kinetic synergistic separation. This dual functionality results in a ∼450-fold difference in diffusion rates and exceptional kinetic selectivity for C 3 F 6 over C 3 F 8 , as demonstrated by adsorption isotherms, time-resolved kinetics, and dynamic breakthrough experiments. Theoretical calculations coupled with in situ spectroscopy elucidate the pore geometry-dependent hopping diffusion mechanism responsible for the separation. This work establishes wiggling pore geometry as a versatile paradigm for advanced adsorbents targeting energy-efficient separations of structurally similar fluorocarbon mixtures.}, archive = {J_ANGEW}, author = {Wei Xia and Zhijie Zhou and Can Xia and Lihang Chen and Liangzheng Sheng and Fang Zheng and Zhiguo Zhang and Qiwei Yang and Qilong Ren and Zongbi Bao}, doi = {10.1002/anie.202503505}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503505}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hopping diffusion in wiggling nanopore architecture of MOF enabling synergistic equilibrium-kinetic separation of fluorinated propylene and propane}, volume = {64}, year = {2025}, }
• (2025). Short lifetime radical metal cluster scintillator. ANGEW, 64(24), e202503457. (www)

  @article{ , abstract = {Metal clusters, an emerging class of scintillator materials, have attracted much attention owing to their inherently high X-ray absorption, mild synthesis conditions, low toxicity, strong luminescence, and large Stokes shift. However, the decay lifetime of metal clusters is usually on the order of microseconds, which is unfavorable for safety inspection, nondestructive testing, and medical imaging. Here, the open-shell luminescent radical ligand was used to construct the first radical cluster scintillator Cu 2 I 2 (L) 4 . The spin-allowed doublet emission of Cu 2 I 2 (L) 4 theoretically enabled 100% exciton utilization and exhibited a short radiation decay lifetime on the nanosecond scale. Cu 2 I 2 (L) 4 can be fabricated into a flexible scintillator screen for X-ray imaging, achieving a high resolution of 30.7 LP mm −1 . More importantly, the Cu 2 I 2 (L) 4 scintillator screen has no residual images during X-ray imaging. This work reports the first luminescent metal cluster with a radical ligand and presents a new strategy for constructing short lifetime X-ray scintillators.}, archive = {J_ANGEW}, author = {Jia-Wang Yuan and Qiu-Chen Peng and Ruo-Yu Cao and Qi Yang and Ying-Ying Lei and Zi-Ying Gao and Zhao-Yang Wang and Kai Li and Shuang-Quan Zang}, doi = {10.1002/anie.202503457}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503457}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Short lifetime radical metal cluster scintillator}, volume = {64}, year = {2025}, }
• (2025). Highly selective oxygen electroreduction to hydrogen peroxide on sulfur-doped mesoporous carbon. ANGEW, 64(24), e202503385. (www)

  @article{ , abstract = {As a paradigm-shifting material platform in energy catalysis, precisely engineered ordered mesoporous carbon spheres emerge as supreme metal-free electrocatalysts, outperforming conventional carbon-based counterparts through synergistic structural and electronic innovations. Herein, we architecturally design vertically aligned cylindrical mesoporous carbon spheres with atomic-level sulfur doping (S-mC) that establish unprecedented performance benchmarks in the two-electron oxygen reduction reaction (2e − -ORR) to hydrogen peroxide. Systematic comparative studies reveal that the S-mC catalysts achieve exceptional H 2 O 2 selectivity (>99%) and activity at current density of −3.5 mA cm −2 , surpassing state-of-the-art metal-free catalysts in current density. Impressively, the optimized S-mC electrocatalyst in a flow cell device achieves an exceptional H 2 O 2 yield of 25 mol g catalyst −1 h −1 . The carbon matrix's unique sp 2 /sp 3 hybrid network coupled with S-induced charge redistribution generates electron-deficient hotspots that selectively stabilize *OOH intermediates, as evidenced by in situ spectroscopic characterization and DFT calculations. This structural–electronic synergy endows the carbon framework with metal-like catalytic efficiency while maintaining inherent advantages of chemical robustness and cost-effectiveness. The marriage of S-doping engineering with mesoscopic pore architecture control opens a new way for developing efficient carbon-based electrocatalysts for oxygen selective reduction to H 2 O 2 .}, archive = {J_ANGEW}, author = {Juan Du and Yicheng Liu and Ming Sun and Jing Guan and Aibing Chen and Buxing Han}, doi = {10.1002/anie.202503385}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503385}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly selective oxygen electroreduction to hydrogen peroxide on sulfur-doped mesoporous carbon}, volume = {64}, year = {2025}, }
• (2025). Redox-mediated lithium recovery from spent LiFePO4 stabilizes ferricyanide catholyte for durable zinc-ferricyanide flow batteries. ANGEW, 64(24), e202503109. (www)

  @article{ , abstract = {The scarcity of lithium resources and the increasing volume of spent lithium-ion batteries (LIBs) exacerbate the imbalance between lithium supply and demand. The development of efficient recovery strategies of valuable lithium ion (Li + ) from spent LIBs and their subsequent utilization presents both significant opportunities and challenges. Here, we propose an innovative approach for Li + recovery from spent lithium iron phosphate (LiFePO 4 ) batteries (LFPs) and its subsequent utilization in alkaline zinc-ferricyanide flow batteries (AZFFBs). Utilizing a redox-mediated reaction, we achieve exceptional Li + recovery efficiency from spent LFPs. Furthermore, the recovered Li + in solution leads to the elevated ionic strength in the electrolyte, enhancing the concentration of [Fe(CN) 6 ] 4− to a remarkable level of 1.74 M. Utilizing the above catholyte, an AZFFB cell demonstrates the cycling life extending to 11 000 cycles with a degradation rate as low as 0.00019% per cycle and 0.09% per day at a current density of 120 mA cm −2 . This study introduces a straightforward and efficient protocol that eliminates additional intermediate processes, achieving effective Li + recovery from spent LFPs and subsequent utilization in flow batteries. The resulting AZFFB exhibits high energy density and long lifespan, positioning it as a promising candidate for large-scale energy storage solutions.}, archive = {J_ANGEW}, author = {Junqiang Wang and Zhexuan Liu and Zhizhao Xu and Mei Ding and Bo Lu and Chuankun Jia and Guangmin Zhou}, doi = {10.1002/anie.202503109}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503109}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-mediated lithium recovery from spent LiFePO4 stabilizes ferricyanide catholyte for durable zinc-ferricyanide flow batteries}, volume = {64}, year = {2025}, }
• (2025). Nitrogen insertion via asymmetric condensation and chirality transfer: A stereodivergent entry to cyanocyclopropanes. ANGEW, 64(24), e202503056. (www)

  @article{ , abstract = {The condensation of prochiral cyclobutanones and diphenylphosphinyl hydroxylamine is achieved under Brønsted acid catalysis. Interestingly, the competing aza-Baeyer–Villiger reaction is completely suppressed and the axially chiral oxime esters can be isolated in excellent yield and selectivity (up to 96% yield, up to 97:3 er). Computational analysis highlights the crucial role of the Brønsted acid in facilitating a successful condensation. Building on the inherent reactivity of the corresponding oxime esters, a one-pot protocol toward cyanocyclopropanes was discovered, which establishes two consecutive stereocenters. This unusual ring contraction is triggered by strong base and permits an axial-to-point chirality transfer with good enantiospecificity (up to 98% es). Fine-tuning the reaction parameters enables stereodivergent access to both diastereomers of the cyanocyclopropanes, and the utility of this method is demonstrated through the formal synthesis of the drug tasimelteon.}, archive = {J_ANGEW}, author = {Marlene Arnold and Jasmin Hammes and Mike Ong and Christian Mück-Lichtenfeld and Johannes M. Wahl}, doi = {10.1002/anie.202503056}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503056}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitrogen insertion via asymmetric condensation and chirality transfer: A stereodivergent entry to cyanocyclopropanes}, volume = {64}, year = {2025}, }
• (2025). Spherical nucleic acids-directed cryosynthesis of manganese nanoagents for tumor imaging and therapy. ANGEW, 64(24), e202503004. (www)

  @article{ , abstract = {DNAzyme-based theranostic nanotechnologies that can respond to specific tumor pathophysiological parameters hold great promise for tumor diagnostics and effective treatments. However, their clinical translation is hindered by insufficient intracellular availability of essential metal cofactors required for DNAzyme activation. To overcome this limitation, we developed a temperature-controlled synthesis strategy for fabricating multifunctional DNA-templated manganese carbonate nanoparticles (DtMnP). The process involves three critical phases: (i) spherical nucleic acid hybrids, DNAzyme-functionalized AuNPs, serve as scaffolds for spatially controlled Mn 2+ deposition through phosphate coordination, initiating heterogeneous nucleation of MnCO 3 ; (ii) rapid liquid nitrogen freezing induces nanoparticle growth along DNA templates; and (iii) lyophilization-mediated structural stabilization enables convenient long-term storage. The DtMnP exhibits pH-responsive dissolution, releasing 90% of Mn 2+ within 60 min under tumor microenvironment conditions (pH 5.5). The released Mn 2+ ion enables dual functionality: (i) superior magnetic resonance imaging (MRI) contrast of MCF-7 xenograft models with enhanced biosafety, and (ii) synergistic therapeutic efficacy through DNAzyme-mediated EGR-1 gene silencing (60% mRNA downregulation) combined with Mn 2+ -catalyzed Fenton reactions generating cytotoxic hydroxyl radicals (45% apoptosis in MCF-7 cells). The cryo-encapsulated DtMnP exemplifies a flexible and efficient approach for integrating various functional components into a single nanoparticle for tumor theranostic applications.}, archive = {J_ANGEW}, author = {Wenjing Xie and Qiangjun Hao and Zi Ye and Rui Sha and Bei Wen and Hailin Wang and Hongquan Zhang and Guohua Jia and X. Chris Le and Guibin Jiang and Hanyong Peng}, doi = {10.1002/anie.202503004}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503004}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spherical nucleic acids-directed cryosynthesis of manganese nanoagents for tumor imaging and therapy}, volume = {64}, year = {2025}, }
• (2025). Plastic from CO2, water, and electricity: Tandem electrochemical CO2 reduction and thermochemical ethylene-CO copolymerization. ANGEW, 64(24), e202503003. (www)

  @article{ , abstract = {Converting CO 2 into industrially useful products is an appealing strategy for utilization of an abundant chemical resource. Electrochemical CO 2 reduction (eCO 2 R) offers a pathway to convert CO 2 into CO and ethylene, using renewable electricity. These products can be efficiently copolymerized by organometallic catalysts to generate polyketones. However, the conditions for these reactions are very different, presenting the challenge of coupling microenvironments typically encountered for the transformation of CO 2 into highly complex but desirable multicarbon products. Herein, we present a system to produce polyketone plastics entirely derived from CO 2 and water, where both the CO and C 2 H 4 intermediates are produced by eCO 2 R. In this system, a combination of Cu and Ag gas diffusion electrodes is used to generate a gas mixture with nearly equal concentrations of CO and C 2 H 4 , and a recirculatory CO 2 reduction loop is used to reach concentrations of above 11% each, leading to a current-to-polymer efficiency of up to 51% and CO 2 utilization of 14%.}, archive = {J_ANGEW}, author = {Maxim Zhelyabovskiy and Hyuk-Joon Jung and Paula L. Diaconescu and Jonas C. Peters and Theodor Agapie}, doi = {10.1002/anie.202503003}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202503003}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plastic from CO2, water, and electricity: Tandem electrochemical CO2 reduction and thermochemical ethylene-CO copolymerization}, volume = {64}, year = {2025}, }
• (2025). High-throughput DFT-assisted design of electrode for efficient high-temperature electrochemical dehydrogenation. ANGEW, 64(24), e202502937. (www)

  @article{ , abstract = {Protonic ceramic electrolysis cell (PCEC) is a promising technique to enable efficient dehydrogenation reactions for producing valuable chemicals, but is still limited by the lack of stable electrocatalysts to achieve efficient O─H/C─H dissociation. In this work, upon high-throughput first-principles calculations, Ba(Zr,Co,Fe,M)O 3 -based (M represents dopants) perovskite is formulated, and oxygen vacancy formation energy ( ) and hydration energy (Δ E hydr ) are taken as two key performance indicators to screen potential PCEC electrode materials derived from this category. Trivalent doping elements, particularly Y, Yb, Er, and Tm, achieve a good balance between and Δ E hydr . Experiments further validate that the BaZr 0.125 Co 0.375 Fe 0.375 Tm 0.125 O 3−δ showed impressive dehydrogenation reaction activity, with faradaic efficiency as high as 98.90% in water electrolysis, and outstanding ethane conversion rate (67.60%) and ethylene yield (62.62%) for ethane dehydrogenation reaction at 700 °C. The computational approach can be applied to the rational design of novel electrode materials for other electrochemical reactions in energy and environment devices.}, archive = {J_ANGEW}, author = {Xuepeng Xiang and Zilin Ma and Jun Zhang and Yifeng Li and Yongjian Ye and Wenyu Lu and Mengzhen Zhou and Shasha Huang and Haijun Fu and Bo Yu and Shijun Zhao and Zhang Lin and Yan Chen}, doi = {10.1002/anie.202502937}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502937}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-throughput DFT-assisted design of electrode for efficient high-temperature electrochemical dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Tandem biocatalysis to generate hydrogen sulfide and promote endogenous antioxidant response. ANGEW, 64(24), e202502917. (www)

  @article{ , abstract = {Promoting cellular protective responses during oxidative stress conditions through the generation of antioxidant persulfide (RS-SH) and hydrogen sulfide (H 2 S) has tremendous therapeutic potential. Here, we report a bioinspired glycoconjugate, a candidate for tandem biocatalysis and generates persulfide/ H 2 S in response to oxidative stress. The glycoconjugate is cleaved by β-galactosidase, an enzyme that is expressed during oxidative stress; the product of this reaction is a substrate for 3-mercaptopyruvate sulfurtransferase (3-MST), an enzyme that is involved in persulfide/ H 2 S biosynthesis. The catalytic systems are orthogonal to one another, and the glycoconjugate is efficiently cleaved by these enzymes to generate the potent antioxidant glutathione persulfide as well as H 2 S. We demonstrate the efficacy of this conjugate in mitigating inflammation in the brain in an animal model. Together, using rationally designed substrates and fully catalytic steps, we leverage tandem biocatalysis to direct the generation of persulfide/ H 2 S, and promote cells’ own antioxidant response.}, archive = {J_ANGEW}, author = {Suman Manna and Simran M. Gupta and Prerona Bora and Arnab Chakraborty and T. Anand Kumar and Siddhesh S. Kamat and Harinath Chakrapani}, doi = {10.1002/anie.202502917}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502917}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem biocatalysis to generate hydrogen sulfide and promote endogenous antioxidant response}, volume = {64}, year = {2025}, }
• (2025). Superfast protein desulfurization triggered by low-energy visible light. ANGEW, 64(24), e202502884. (www)

  @article{ , abstract = {The combination of transthioesterification-based ligation of thiol-derived amino acids and the post-ligation desulfurization has greatly expanded the scope of modern chemical protein synthesis. Here, we report a new strategy of low-energy visible light-induced desulfurization (LEnVLD) that enables superfast and clean protein desulfurization (half life = 1.7 s) with improved reaction selectivity compared to the previous methods. The LEnVLD method can be easily carried out under very mild conditions using only a catalytic amount of fluorescent dye and household flashlight (ca. 5 W) irradiation, eliminating the need for any pyrophoric reagent, thiol additives, or excessive radical initiators, and its practicality was demonstrated by the fast and high-yielding desulfurization of more than 30 peptide and protein substrates bearing a variety of sensitive functional groups (e.g., Thz, N-alkylated maleimide, and thioester). Moreover, the convenience and robustness of LEnVLD enable its extension to versatile reaction scenarios (e.g., solid-supported desulfurization and flow chemistry-based desulfurization) that would enhance the practical capability of chemical protein synthesis.}, archive = {J_ANGEW}, author = {Dongyang Han and Xiangyu Deng and Yan Cui and Xianglai Zhu and Guiyu Deng and Lu-Jun Liang and Guo-Chao Chu and Lei Liu}, doi = {10.1002/anie.202502884}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502884}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Superfast protein desulfurization triggered by low-energy visible light}, volume = {64}, year = {2025}, }
• (2025). A novel tandem reaction system for high-concentration acetic acid production from methane and oxygen. ANGEW, 64(24), e202502822. (www)

  @article{ , abstract = {Directly converting methane into high-value products like CH 3 COOH poses significant challenges owing to the kinetic limitations of C─H activation and C─C coupling in traditional single-catalysis methods. This work systematically studied the compatibility and effectiveness of plasma and thermocatalytic tandem systems. By optimizing the plasma process in a self-designed dielectric barrier discharge (DBD) reactor, we enhanced methane conversion (68.0%), methanol concentration (5.2 mol L −1 ), and CO selectivity (56.9%), while preventing carbon deposition and CO 2 formation. In subsequent thermocatalysis, we developed the stearic acid-modified ReRh/ZSM-5-S hydrophobic catalyst to avoid the separation of methanol and CO from the mixture and minimize the influence of by-products (e.g., H 2 O). This innovative approach achieved 52.0% CH 3 COOH selectivity and 1.3 mol L −1 concentrations, three orders of magnitude than traditional methods, meeting the preliminary industrial criteria. This study demonstrates the potential of tandem catalysis, offering valuable insights for the efficient utilization of methane and other challenging catalytic reactions.}, archive = {J_ANGEW}, author = {Haonan Zhang and Yang Li and Shuai Wang and Shuxu Zhu and Chaoqun Gu and Pengye Zhang and Hongjie Qin and Runze Guo and Wenbin Wang and Tianshi Xu and Gaiyan Jiao and Jianrong Zeng and Yanyan Xi and Qi Hua and Mingbo Wu and Wenting Wu}, doi = {10.1002/anie.202502822}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502822}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A novel tandem reaction system for high-concentration acetic acid production from methane and oxygen}, volume = {64}, year = {2025}, }
• (2025). Reductive catalytic fractionation of lignocellulose toward propyl- or propenyl-substituted monomers and mechanistic understanding. ANGEW, 64(24), e202502545. (www)

  @article{ , abstract = {Reductive catalytic fractionation (RCF) is a promising technology that can selectively extract lignin in biomass and depolymerize it. Here, we prepared one low Ru loading catalyst (Ru 0.8 /C) for RCF of biomass to selectively produce different lignin oils (both monomers and oligomers) under different reaction atmospheres. The yield of phenolic monomers reached 46.0wt.% (rich in 4-propylguaiacol and 4-propylsyringol) in the RCF of birch wood under high H 2 pressure and using methanol as the solvent. But, under N 2 atmosphere the dominant monomers shifted to 4-(prop-1-enyl)guaiacol and 4-(prop-1-enyl)syringol (79.6% selectivity) with 35.8wt.% yield of total monomers using the same catalyst. The developed catalyst can also transform native lignin in other biomasses such as pine and corn stover. Mechanistic investigation using different model compounds and deuteration indicates that removal of the C γ ─OH in methanol-extracted lignin fragments occurred before obtaining the monomeric lignin fragment, and the C α ─OH and β─O─4 bonds were then cleaved simultaneously to form 4-(prop-1-enyl) substituted monomers. The results are distinct from the reported mechanism that the precursors of the propyl and prop-1-enyl substituted monomers are monolignols with removal of the C γ ─OH at the monomeric level. Thus, this work provided novel insights into the reaction pathway of (native) lignin depolymerization.}, archive = {J_ANGEW}, author = {Haiyun Huang and Xinghua Zhang and Longlong Ma and Yuhe Liao}, doi = {10.1002/anie.202502545}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502545}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reductive catalytic fractionation of lignocellulose toward propyl- or propenyl-substituted monomers and mechanistic understanding}, volume = {64}, year = {2025}, }
• (2025). Late-stage cross-electrophile coupling of arylthianthrenium salts with (Hetero)aryl (Pseudo)halides via palladium catalysis. ANGEW, 64(24), e202502441. (www)

  @article{ , abstract = {Herein, we present a cross-coupling reaction of arylthianthrenium salts at a late stage with diverse (hetero)aryl (pseudo)halides under reductive conditions, in which a palladium(0) catalyst differentiates between two aryl electrophiles based on the different rates of oxidative addition of arylthianthrenium salts and aryl halides for selective umpolung. A measured near-zero Hammett rho value is consistent with oxidative addition of the arylthianthrenium salts to palladium(0) being insensitive to substituent effects, which enables reaction with structurally and electronically diverse arylthianthrenium salts. In addition, we show the robustness of this method by coupling of two complex fragments that would otherwise be difficult to access in a single step.}, archive = {J_ANGEW}, author = {Yuanhao Xie and Li Zhang and Tobias Ritter}, doi = {10.1002/anie.202502441}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502441}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Late-stage cross-electrophile coupling of arylthianthrenium salts with (Hetero)aryl (Pseudo)halides via palladium catalysis}, volume = {64}, year = {2025}, }
• (2025). Mn(II)-based hybrid halide ionogel scintillator film for large-area and high-resolution X-ray imaging. ANGEW, 64(24), e202502440. (www)

  @article{ , abstract = {Functionalized ionogels have attracted significant attention in chemical design of new materials and versatile applications, which are formed by polymer network as a matrix with introducing ionic liquids containing characteristic units as a dispersion medium. Here, we present an universal scheme to rapidly synthesize luminescent ionogels through the in situ formation of zero-dimensional (0D) hybrid metal halides during the polymerization of monomer. In particular, Mn(II)-based hybrid halide ionogels (Mn─IG) were formed by incorporating [C 20 H 20 P] + cations and [MnBr 4 ] 2− anions into the polymer network structure. Thanks to the amorphous nature of Mn-IG and the homogeneous distribution of self-trapped [MnBr 4 ] 2− light-emitting units with [C 20 H 20 P] + cations, Mn─IG exhibits high transparency (nearly 90% transmittance at 550 nm-1100 nm) and homogeneous highly-efficient emission. Taking advantage of its processability, we fabricate an 18 cm × 12 cm scintillation film and successfully realize large-area and high-resolution X-ray imaging. The straightforward and rapid synthesis method on such ionogels paves the way for the low-process-demand preparation of large-area scintillators, and also opens up new routes for the in situ construction of uniform 0D metal halide polymer composites.}, archive = {J_ANGEW}, author = {Bohan Li and Kai Han and Yuzhen Wang and Yongsheng Sun and Zhiguo Xia and Yan Xu}, doi = {10.1002/anie.202502440}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502440}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mn(II)-based hybrid halide ionogel scintillator film for large-area and high-resolution X-ray imaging}, volume = {64}, year = {2025}, }
• (2025). Predator–Prey behavior of droplets propelling through self-generated channels in crystalline surfactant layers. ANGEW, 64(24), e202502352. (www)

  @article{ , abstract = {Motile droplets provide an attractive platform for liquid matter-based applications and protocell analogues displaying life-like features. The functionality of collectively operating droplets increases by the advance of well-designed (physico)chemical systems directing droplet–droplet interactions. Here, we report a strategy based on crystalline surfactant layers at air/water interfaces, which sustain the propulsion of floating droplets and at the same time shape the paths for other droplets attracted by them. First, we show how decylamine forms a closed, crystalline layer that remains at the air/water interface. Second, we demonstrate how aldehyde-based oil droplets react to decylamine in the crystalline layer by forming an imine, causing the droplets to move through the layer while leaving behind an open channel (comparable to “Pac-Man”). Third, we introduce tri(ethylene glycol) monododecylether (C 12 E 3 ) droplets in the crystalline layer. The crystalline layer suppresses the motion of the C 12 E 3 droplets, however, the aldehyde droplets create surface tension gradients upon depletion of surfactants from the air/water interface, thereby driving Marangoni flows that attract the C 12 E 3 droplets as well as the myelin filaments they grow: Causing the C 12 E 3 droplets to chase, and ultimately catch, the aldehyde droplets along the channels they have created, featuring a predator-prey analogy established at an air/water interface.}, archive = {J_ANGEW}, author = {Priyanshu Singh and Peter A. Korevaar}, doi = {10.1002/anie.202502352}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502352}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Predator–Prey behavior of droplets propelling through self-generated channels in crystalline surfactant layers}, volume = {64}, year = {2025}, }
• (2025). Regiospecific halogenation modulates molecular dipoles in self-assembled monolayers for high-performance organic solar cells. ANGEW, 64(24), e202502215. (www)

  @article{ , abstract = {Halogenated carbazole-derived self-assembled monolayers (SAMs) are promising hole-extraction materials in conventional organic solar cells (OSCs). While halogenation helps optimize the molecular dipole, intermolecular interactions, and energetics of SAM, the highly polarizable carbon-halogen bonds can be reactive and prone to photocleavage depending on their regiochemistry. Herein, we study the regiospecific properties, including the intrinsic stability, electrostatic potential (ESP) distribution, and changes in molecular dipole of the brominated SAM molecules by brominating a helical 7 H -dibenzo[ c,g ]carbazole-based SAM (CbzNaph) featuring a stronger dipole. Additionally, a correlation between the intrinsic molecular stability and the derived SAM surface stability is established to determine the performance and stability of the OSCs. Notably, the bromination at the chemically inert sites of 7 H -dibenzo[ c,g ]carbazole (JJ26) helps maximize molecular dipole while maintaining superior intrinsic stability. Together with dense assembly promoted by the synergistically enhanced intermolecular interactions and crystallinity, JJ26 can efficiently modulate the work function (WF) of indium tin oxide (ITO) and enhance the stability of SAM under external stress. Consequently, the JJ26 derived OSC shows significantly improved performance, achieving an efficiency of 19.35% along with notably enhanced stability. This work shows that the precise modulation of the regiochemistry of SAM molecules is critical for improving their quality and derived device performance.}, archive = {J_ANGEW}, author = {Wenlin Jiang and Yanxun Li and Huanhuan Gao and Lingchen Kong and Chun-To Wong and Xi Yang and Francis R. Lin and Alex K.-Y. Jen}, doi = {10.1002/anie.202502215}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502215}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regiospecific halogenation modulates molecular dipoles in self-assembled monolayers for high-performance organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Rhodium-catalyzed atroposelective synthesis of axially chiral 1-aryl isoquinolines via de novo isoquinoline formation. ANGEW, 64(24), e202502131. (www)

  @article{ , abstract = {Axially chiral heterobiaryl moieties serve as core skeletons for bioactive molecules, chiral ligands, and organocatalysts. Enantioselective de novo formation of the heteroaromatic ring is one of the most straightforward approaches to access enantioenriched heterobiaryls. Herein, an enantioselective de novo construction of isoquinolines by rhodium-catalyzed C─H activation/annulation of aromatic imines with alkynes is disclosed. This approach is operationally simple, allowing for rapid access to a variety of axially chiral 1-aryl isoquinolines in excellent yields and enantioselectivity (up to 98% yield and 99:1 er). The synthetic application of the current method was demonstrated by functional group transformations and suitability for millimolar-scale reactions. Detailed experimental and theoretical studies revealed the turnover-limiting step and provided insight into the origin of the enantioselectivity for this reaction.}, archive = {J_ANGEW}, author = {Bo-Bo Gou and Wen-Jie Shen and Yuan-Jun Gao and Qing Gu and Shu-Li You}, doi = {10.1002/anie.202502131}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502131}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhodium-catalyzed atroposelective synthesis of axially chiral 1-aryl isoquinolines via de novo isoquinoline formation}, volume = {64}, year = {2025}, }
• (2025). Supramolecular gels as active tools for reaction engineering. ANGEW, 64(24), e202502053. (www)

  @article{ , abstract = {Supramolecular gels, assembled from low-molecular-weight gelators (LMWGs), are fascinating soft materials for use in synthesis, combining aspects of hetero- and homogeneous systems. The unique combination of environments within a gel offers the ability to control reactivity in new ways. For example, self-assembly into a gel network can modify the reactivity of catalytic sites on the LMWG. Controlling the assembly of multiple LMWGs can result in integrated gels with orthogonal activities that could not normally coexist. Enzymes encapsulated within self-assembled gels can exhibit superactivity, extending their use into solvent media more appropriate for organic synthesis. Highly reactive species, such as ligand-free nanoparticles or moisture/air-sensitive organometallics, can be protected within the unique environment of a supramolecular gel, facilitating their use in ambient conditions, potentially opening up the use of such species to nonspecialist researchers. Beyond fundamental chemistry, performing reactions in gels leads to the emerging concept of gels as “nanoreactors”. Smart chemical engineering methods are enabling the fabrication of materials and devices for use in a variety of synthetic workflows, potentially transforming the way synthesis is done. In summary, this review provides an overview of key concepts and signposts the way toward future developments of gels as active tools for reaction engineering.}, archive = {J_ANGEW}, author = {David K. Smith}, doi = {10.1002/anie.202502053}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502053}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular gels as active tools for reaction engineering}, volume = {64}, year = {2025}, }
• (2025). Integrating ambient ionization mass spectrometry imaging and spatial transcriptomics on the same cancer tissues to identify RNA–Metabolite correlations. ANGEW, 64(24), e202502028. (www)

  @article{ , abstract = {Innovations in spatial omics technologies applied to human tissues have led to breakthrough discoveries in various diseases, including cancer. Two of these approaches—spatial transcriptomics and spatial metabolomics—have blossomed independently, fueled by technologies such as spatial transcriptomics (ST) and mass spectrometry imaging (MSI). Although powerful, these technologies only offer insights into the spatial distributions of restricted classes of molecules and have not yet been integrated to provide more holistic insights into biological questions. These techniques can be performed on adjacent serial sections from the same sample, but section-to-section variability can convolute data integration. We present a novel method combining desorption electrospray ionization mass spectrometry imaging (DESI-MSI) spatial metabolomics and Visium spatial transcriptomics on the same tissue sections. We show that RNA quality is maintained after performing DESI-MSI on a tissue under ambient conditions and that ST data is unperturbed following DESI-MSI. We demonstrate this workflow on human breast and lung cancer tissues and identify novel correlations between metabolites and mRNA transcripts in cancer-specific tissue regions.}, archive = {J_ANGEW}, author = {Trevor M. Godfrey and Yasmin Shanneik and Wanqiu Zhang and Thao Tran and Nico Verbeeck and Nathan H. Patterson and Faith E. Jackobs and Chandandeep Nagi and Maheshwari Ramineni and Livia S. Eberlin}, doi = {10.1002/anie.202502028}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202502028}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating ambient ionization mass spectrometry imaging and spatial transcriptomics on the same cancer tissues to identify RNA–Metabolite correlations}, volume = {64}, year = {2025}, }
• (2025). Self-optimized reconstruction of Metal–Organic frameworks introduces cation vacancies for selective electrosynthesis of hydrogen peroxide. ANGEW, 64(24), e202501930. (www)

  @article{ , abstract = {The electrocatalytic synthesis of hydrogen peroxide (H 2 O 2 ) through the two-electron oxygen reduction pathway represents a green production process that has gained increasing importance. Nevertheless, there is a dearth of efficacious catalysts to attain high activity under industrial current density. In this study, we present a strategy for cation vacancy generation through metal–organic frameworks self-optimized reconfiguration for the efficient electrosynthesis of H 2 O 2 under industrial current densities in solid-electrolyte cell. The ZIF-ZC91@Co(OH) 2 -V Co electrocatalyst exhibits significant H 2 O 2 selectivity of 97.8%, and the H 2 O 2 productivity is up to 24.53 mol g catalyst −1 h −1 with a direct and continuous output of ∼3.36 wt% H 2 O 2 aqueous solutions under industrial current density (400 mA cm −2 ). Impressively, the ZIF-ZC91@Co(OH) 2 -V Co possesses superb long-term durability for over 220 h and can output H 2 O 2 aqueous solution with a concentration of ∼8.03 wt% in the pilot experiment. Theoretical calculations confirm that the introduction of modest cation vacancies optimizes the adsorption strength of *OOH intermediate and reduces both thermodynamic and kinetic barriers, thus balancing the selectivity of the two-electron oxygen reduction. This work provides valuable insights into the rapid, eco-friendly synthesis of H 2 O 2 and the rational design of highly active catalysts.}, archive = {J_ANGEW}, author = {Chao Miao and Shaohan Xu and Ziwen An and Xun Pan and Yanbo Li and Nan Hu and Lina Li and Yongxin Zhou and Guohua Zhao}, doi = {10.1002/anie.202501930}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202501930}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-optimized reconstruction of Metal–Organic frameworks introduces cation vacancies for selective electrosynthesis of hydrogen peroxide}, volume = {64}, year = {2025}, }
• (2025). Interfacial H-bond Network/Concentration Fields/Electric fields regulation achieved by D-valine anions realizes the highly efficient aqueous zinc ion batteries. ANGEW, 64(24), e202501721. (www)

  @article{ , abstract = {Uncontrolled mobile anions and proton transport result in many issues, including interfacial anion depletion, irregular multiphysics fields fluctuations, space charge layer-induced interfacial Zn dendrites, and hydrogen evolution reaction (HER), which seriously exacerbates the cycling stability of zinc-ion batteries. Herein, this work constructs an efficient D-valine anion interface structure to reversely regulate the Zn 2+ /H + dynamic chemistry and unlocks the multiple regulation effects of this anionic interface by investigating interfacial proton transport and complex concentration/electric fields distribution of Zn anode through dynamic in-situ spectroscopy analysis, static energy calculations, and molecular dynamics simulation. We unravel core factors affecting complicated interfacial HER processes and the generation of the space charge layer. This anionic interfacial layer severs proton hopping transport by rupturing the initial water–water hydrogen bond, which effectively restrains uncontrolled HER processes. Further, the anion-immobilized interfacial layer accelerates Zn 2+ transfer to optimize the interfacial concentration fields. Also, the anionic interface restrains the formation of the anion depletion layer by relieving rapid Zn 2+ ions exhaustion and strengthening the uniformity of interfacial electrical field distribution, which suppresses space charges-induced Zn dendrite growth. Consequently, Zn||Zn symmetric cells deliver an ultralong cycle life of 4150 h. Importantly, the multiple regulation effects enable Zn||I 2 cells exhibit long-term stable life.}, archive = {J_ANGEW}, author = {Jiadong Lin and Chenchen Ji and Gaozhi Guo and Yulu Luo and Pengru Huang and Fen Xu and Lixian Sun and Wilhelm Pfleging and Kostya S. Novoselov}, doi = {10.1002/anie.202501721}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202501721}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial H-bond Network/Concentration Fields/Electric fields regulation achieved by D-valine anions realizes the highly efficient aqueous zinc ion batteries}, volume = {64}, year = {2025}, }
• (2025). Aptamer-based galvanic potentiometric sensor for real-time monitoring of serotonin signaling under psychosocial stress. ANGEW, 64(24), e202501701. (www)

  @article{ , abstract = {Psychosocial stress, a pervasive factor in mental health disorders, is tightly linked to serotonin (5-HT) dysregulation. Real-time electrochemical monitoring of 5-HT in vivo is challenged by interference from vitamin C (Vc) and biofouling, requiring invasive pretreatments. We present a self-powered aptamer-engineered galvanic sensor (aptGRP 5-HT ) that integrates phosphorothioate aptamers with a redox potentiometric mechanism, achieving 21.5-fold higher selectivity and 98.3-fold enhanced sensitivity against Vc over conventional sensors while resisting electrochemical biofouling. The aptGRP 5-HT operates in complex biological environments without pretreatment, enabling direct monitoring in a rodent psychosocial stress model. Using this tool, we uncover a neurochemical signature of social hierarchy: high-ranking mice exhibit elevated 5-HT release in the medial prefrontal cortex (mPFC) and dorsal raphe nucleus (DRN), with region-specific correlations to neuronal activity-reduced spontaneous firing in the mPFC and increased activity in the DRN. This work resolves long-standing challenges in neurochemical sensing and establishes aptGRP 5-HT as a transformative platform for probing brain function and stress-related disorders.}, archive = {J_ANGEW}, author = {Fenghui Zhu and Yinghuan Liu and Zhining Sun and Jiping Ni and Ying Jiang}, doi = {10.1002/anie.202501701}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202501701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aptamer-based galvanic potentiometric sensor for real-time monitoring of serotonin signaling under psychosocial stress}, volume = {64}, year = {2025}, }
• (2025). Cobalt-catalyzed enantioselective hydrotrifluoromethoxylation of aromatic alkenes. ANGEW, 64(24), e202501680. (www)

  @article{ , abstract = {The construction of optically pure benzyl trifluoromethoxy (OCF 3 ) compounds continues to present challenges due to limited enantioselectivity-control or the necessity for OCF 3 -containing substrates in the only two previous reports. Herein, we have developed a salen-Co-catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.}, archive = {J_ANGEW}, author = {Yafeng Si and Yuntao Liu and Fan Zhou and Lei Fang and Kang Wu and Yu-Xin Luan and Li Chen and Pingping Tang}, doi = {10.1002/anie.202501680}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202501680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-catalyzed enantioselective hydrotrifluoromethoxylation of aromatic alkenes}, volume = {64}, year = {2025}, }
• (2025). Oxidative rearrangements of the alkaloid intermediate geissoschizine. ANGEW, 64(24), e202501323. (www)

  @article{ , abstract = {Plants can generate structural diversity by enzymatic rearrangement of a central intermediate. 19 E -geissoschizine is one such chemically versatile intermediate that plays a central role in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Here we report how 19 E -geissoschizine undergoes oxidative transformations to generate four distinct alkaloid scaffolds through the action of three biosynthetic enzymes. Using in vitro enzymatic assays and gene silencing, we demonstrate how these three cytochrome P450 enzymes in the medicinal plant Catharanthus roseus transform 19 E -geissoschizine into strychnos , sarpagan , akuammiline -type, and mavacurane- type alkaloids. We use mutational analysis to show how minimal changes to the active site of these similar enzymes modulate product specificity. This work highlights how substrate reactivity and enzyme mutations work synergistically to generate chemical diversity.}, archive = {J_ANGEW}, author = {Mohamed O. Kamileen and Benke Hong and Klaus Gase and Maritta Kunert and Lorenzo Caputi and Benjamin R. Lichman and Sarah E. O'Connor}, doi = {10.1002/anie.202501323}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202501323}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxidative rearrangements of the alkaloid intermediate geissoschizine}, volume = {64}, year = {2025}, }
• (2025). Enhancing efficiency and stability of inverted flexible perovskite solar cells via multi-functionalized molecular design. ANGEW, 64(24), e202501267. (www)

  @article{ , abstract = {Inverted flexible perovskite solar cells (f-PSCs) are promising candidates for mechanical photovoltaic applications due to their ease of preparation, lightweight, and portability. However, the weak interface connections, residual strain, and the nonradiative recombination loss among adjacent layers are critical challenges that restrict f-PSCs development. To address these issues, a functionalized molecule with multiple hydrogen bond acceptors, 4-Carboxyphenylboronic acid (4-BBA), is designed in the perovskite precursor for modulating perovskite crystallization, which achieves uniform and stress-relaxation perovskite film and forms a robust bridging structure anchored at the buried interface. Theoretical calculation and experimental results show that the C═O group passivates Pb 2+ with I − vacancy defect through Lewis acid-base interactions, reducing trap-assisted recombination. Furthermore, the designed 4-BBA is preferentially deposited at the buried layer interface between the perovskite and substrate, forming hydrogen bonds with the self-assembled monolayer via B─OH bonds, creating a mechanically stable bridge between the layers. As a result, the power conversion efficiency of the champion f-PSC reached 25.30% (25.13% certified). And the f-PSC open-circuit voltage set a record of 1.21V. Importantly, the unencapsulated f-PSC using 4-BBA retains 95.3% of its original performance after 5000 cycles at a bending radius of 10mm, demonstrating extraordinary bending stability.}, archive = {J_ANGEW}, author = {Hongbo Liang and Wenjing Zhu and Zhichao Lin and Bin Du and Hao Gu and Tianwen Chen and Fenqi Du and Laju Bu and Yibo Zhou and Xianqiang Xie and Yingjie Zhu and Yuexin Lin and Wenhan Yang and Nan Zhang and Liming Ding and Shengchun Yang and Chao Liang}, doi = {10.1002/anie.202501267}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202501267}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing efficiency and stability of inverted flexible perovskite solar cells via multi-functionalized molecular design}, volume = {64}, year = {2025}, }
• (2025). Decoding the chemical language of ribosomally synthesized and post-translationally modified peptides from the untapped archaea domain. ANGEW, 64(24), e202501074. (www)

  @article{ , abstract = {Chemical communication is crucial in ecosystems with complex microbial communities. However, the difficulties inherent to the cultivation of archaea have led to a limited understanding of their chemical language, especially regarding the structure diversity and function of secondary metabolites (SMs). Our in-depth exploration into the biosynthetic potential of archaea has unveiled the previously unexplored biosynthetic capabilities and chemical diversity of archaeal ribosomally synthesized and post-translationally modified peptides (RiPPs). Through the first application of heterologous expression in archaeal SM discovery, we have identified 24 lanthipeptides, including a distinctive type featuring diamino-dicarboxylic termini. It highlights the uniqueness of archaeal biosynthetic pathways and significantly expands the chemical landscape of archaeal SMs. Additionally, archaeal lanthipeptides demonstrate antagonistic activity against haloarchaea, mediating the unique biotic interaction in the halophilic niche. They showcase a new ecological role of RiPPs in enhancing the host's motility by inducing the rod-shaped cell morphology and upregulating the archaellin gene expression, facilitating the archaeal interaction with abiotic environments. These discoveries broaden our understanding of archaeal chemical language and provide promising prospects for future exploration of SM-mediated interaction.}, archive = {J_ANGEW}, author = {Zhi-Man Song and Cunlei Cai and Ying Gao and Xiaoqian Lin and Qian Yang and Dengwei Zhang and Gengfan Wu and Haoyu Liang and Qianlin Zhuo and Junliang Zhang and Peiyan Cai and Haibo Jiang and Wenhua Liu and Yong-Xin Li}, doi = {10.1002/anie.202501074}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202501074}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoding the chemical language of ribosomally synthesized and post-translationally modified peptides from the untapped archaea domain}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed umpolung difluoroalkylation of imines enables general access to β-difluoroalkylated amines. ANGEW, 64(24), e202500990. (www)

  @article{ , abstract = {Fluoroalkylated amines play a pivotal role in medicinal chemistry, yet the general and efficient synthesis of β-difluoroalkylated amines remains elusive. Here, we developed a nickel-catalyzed umpolung strategy that enables the difluoroalkylation of 2-azaallyl anions generated from aliphatic and aromatic imines, effectively overcoming the previous limitations. By inverting the polarity of imines, this strategy allows for the coupling of a variety of readily accessible difluoroalkyl bromides and iodides. This approach is characterized by its high efficiency, broad substrate scope, high functional group tolerance, and ease of synthesis. The rapid modification of bioactive molecules by the efficient synthesis of difluorinated analogs of key amine moieties present in bioactive molecules, including amphetamine, using the current approach shows the promising potential of this protocol in advancing drug discovery and development.}, archive = {J_ANGEW}, author = {Fei-Fei Tong and Xiao-Tian Feng and Yuan-Zhan Han and Ming-Chen Huang and Hai-Yang Zhao and Xingang Zhang}, doi = {10.1002/anie.202500990}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500990}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed umpolung difluoroalkylation of imines enables general access to β-difluoroalkylated amines}, volume = {64}, year = {2025}, }
• (2025). Oligoether chain engineering in covalent organic frameworks: Enhancing transport pathways and oxygen reduction activity for efficient electrocatalytic hydrogen peroxide production. ANGEW, 64(24), e202500945. (www)

  @article{ , abstract = {Oligoethers with various numbers of ethylene oxide (EO) units, known for their flexibility, electronegativity, and hydrophilicity, can be leveraged to construct complex molecular architectures with broad applicability. In this study, we present the synthesis of two-dimensional (2D) covalent organic frameworks (COFs) incorporating oligoethers with EO segments of varying lengths (2D-COF-EOs) to explore the role of EO units in modulating the two-electron (2e − ) oxygen reduction reaction (ORR) pathway for electrocatalytic hydrogen peroxide (H 2 O 2 ) production. By embedding hydrophilic EO side chains into the hydrophobic frameworks, intermolecular interactions are promoted through hydrogen bonding, leading to the self-assembly and spatial aggregation of these side chains. The high crystallinity of the COFs facilitates orderly stacking of the skeleton, creating hydrophilic nanoscale transport channels that enhance ORR kinetics. Among the synthesized COFs, 2D-COF-EO 1 , which contains one EO group, exhibits a remarkable H 2 O 2 production rate of 5820 mmol g cat −1 h −1 and a 2e − ORR selectivity of 89.2%. Theoretical calculations and in situ electrocatalytic experiments reveal that the elongation of the EO units significantly alters the electronic structure of carbon atoms adjacent to oxygen atoms, lowering the energy barriers associated with the formation of OOH* intermediates and thus promoting the 2e − ORR pathway. This work offers valuable insights into optimizing COFs with different EO units for efficient 2e − ORR-based electrocatalytic processes.}, archive = {J_ANGEW}, author = {Guochao Liu and Min Lin and Yali Xing and Shuqi Cheng and Han Wang and Daohao Li and Xiaojing Long and Qianrong Fang}, doi = {10.1002/anie.202500945}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500945}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oligoether chain engineering in covalent organic frameworks: Enhancing transport pathways and oxygen reduction activity for efficient electrocatalytic hydrogen peroxide production}, volume = {64}, year = {2025}, }
• (2025). Design and construction of D-A-extended 3D Covalent–Organic frameworks for boosting photocatalytic hydrogen evolution. ANGEW, 64(24), e202500937. (www)

  @article{ , abstract = {The development of donor–acceptor (D-A) covalent–organic frameworks (COFs) has emerged as a promising strategy for enhancing photocatalytic performance. Although most studies have concentrated on 2D COFs, research into their 3D counterparts remains limited. In this study, we rationally designed and synthesized a carbazoyl dicyanobenzene derivative (TBFCC) as an intrinsic D-A building block. By selecting TAPA, TAPB, and TAPT as the donor, acceptor-π, and acceptor donors, respectively, we synthesized three distinct D-A-extended COF materials: D-D-A, A-π-D-A, and A-D-A. Among these, 3D-TAPT-COF, featuring an A-D-A structure, exhibited the highest hydrogen evolution rate of 31.3 mmol g −1 h −1 , surpassing most previously reported 3D COF-based photocatalysts. This superior performance is attributed to its A-D-A configuration, which provides multiple charge transfer pathways in 3D space, overcoming the electron transport limitations inherent in 2D COFs. Consequently, this feature facilitates efficient separation of photogenerated charges within the framework and reduces carrier recombination, thereby optimizing photocatalytic efficiency.}, archive = {J_ANGEW}, author = {Huijie Li and Jie Fan and Mengxu Ran and Rahul Anil Borse and Shao-Xia Lin and Daqiang Yuan}, doi = {10.1002/anie.202500937}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500937}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design and construction of D-A-extended 3D Covalent–Organic frameworks for boosting photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Direct conversion of aromatic lactones into bioisosteres by carbonyl-to-boranol exchange. ANGEW, 64(24), e202500921. (www)

  @article{ , abstract = {Bioisosteric replacement is an important strategy in drug discovery and is commonly practiced in medicinal chemistry; however, the incorporation of bioisosteres typically requires laborious multistep de novo synthesis. The direct conversion of a functional group into its corresponding bioisostere is of particular significance in evaluating structure-property relationships. Herein, we report a functional-group-exchange strategy that enables the direct conversion of aromatic lactones, a prevalent motif in bioactive molecules, into their corresponding cyclic hemiboronic acid bioisosteres. Scope evaluation and product derivatization experiments demonstrate the synthetic value and broad functional-group compatibility of this strategy, while the application of this methodology to the rapid remodeling of chromenone cores in bioactive molecules highlights its utility.}, archive = {J_ANGEW}, author = {Yu Zhang and Hong Lu and Jie Chang and Peng-Fei Xu and Hang Li and Yuan Jin and Hao Wei}, doi = {10.1002/anie.202500921}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500921}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct conversion of aromatic lactones into bioisosteres by carbonyl-to-boranol exchange}, volume = {64}, year = {2025}, }
• (2025). Redox-controlled, sequential self-sorting of supramolecular assemblies in model protocells. ANGEW, 64(24), e202500456. (www)

  @article{ , abstract = {Self-sorting of cellular components is essential for maintaining order and function in living systems, enabling complex processes to operate seamlessly. Emulating such self-sorting in synthetic self-assembly, however, has conventionally relied on structural or chirality mismatches of monomers yielding self-sorted systems under thermodynamic conditions. In contrast, reaction-coupled, kinetically controlled self-assembly, ubiquitous in biological systems, is critical for achieving spatiotemporal characteristics. Extending this principle to temporally self-sorted synthetic assemblies is key to developing multi-component biomimetic systems. Herein, we present a strategy towards this direction, to achieve sequential self-sorting of supramolecular assemblies through differences in the chemical-reactivity of monomers, coupled to redox-reactions. This approach exploits the distinct redox potentials of monomers to achieve precise temporal-control over self-sorting, while inherent structural mismatches among monomers ensure the kinetic stability of self-sorted state. Reduction reactions transiently disrupt their assemblies into dormant inactive monomeric states, while subsequent kinetically controlled reassembly occurs via reversible oxidation reactions. Finally, utilizing this sequential self-sorting, we aim to mimic multicomponent cellular self-organization by demonstrating the kinetically controlled growth of self-sorted structures in the presence of model protocells, using lipid vesicles as compartments. Although spatial-distribution remains non-selective, the dormant monomeric states facilitate monomer encapsulation and the unprecedented stepwise-formation of self-sorted assemblies within model protocells.}, archive = {J_ANGEW}, author = {Satyajit Patra and Shikha Dhiman and Subi J. George}, doi = {10.1002/anie.202500456}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-controlled, sequential self-sorting of supramolecular assemblies in model protocells}, volume = {64}, year = {2025}, }
• (2025). A capping-assisted strategy for synthesis of glass-like carboxylate-based coordination polymers. ANGEW, 64(24), e202500266. (www)

  @article{ , abstract = {The direct preparation of glass-like carboxylate-based coordination polymers (CPs) possessing continuous internal structure and transparency is challenging due to the lack of control on coordination kinetics and subsequently the range of order. Herein, a capping-assisted strategy was presented to control the molecular assembly during the metal-ligand coordination in the solution and to inhibit the long-range of order hence building glass-like CPs (g-CPs) mimicking the polymerization process. 1,3,5-benzene tricarboxylate (BTC) ligand was used to connect the copper cations (Cu 2+ ) into metal-organic complexes of different Cu: BTC ratios (metal-organic pool) in presence of an excess of triethyl amine as a capping agent. Concentrating the Cu-BTC complexes and further drying under mild conditions induced the decapping process which triggered the random crosslinking between the free carboxylate and Cu 2+ to form a boundary-free continuous internal structure. The as-prepared Cu-BTC g-CP exhibited an approximately similar fine structure like its crystalline counterpart (HKUST-1), which facilitated solvent and thermal-induced crystallization. Due to the internal structure continuity, the g-CP possesses ceramic-like hardness and wear resistance and plastic-like resilience. This capping-assisted strategy has been successfully extended to Ni-BTC and Fe-BTC systems under mild conditions and thus presenting a general method for the formation of glass-like carboxylate-based CPs.}, archive = {J_ANGEW}, author = {Mohamed K. Albolkany and Songlin Cui and Yuan Zhao and Bo Liu}, doi = {10.1002/anie.202500266}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500266}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A capping-assisted strategy for synthesis of glass-like carboxylate-based coordination polymers}, volume = {64}, year = {2025}, }
• (2025). New transferrin receptor-targeting conjugate effectively delivers DNA to mouse brain. ANGEW, 64(24), e202500247. (www)

  @article{ , abstract = {Delivery across the blood–brain barrier (BBB) is one of the most challenging tasks for modern biopharmaceutics. Many attempts have been taken, with only low delivery efficacies achieved so far. We report a new transferrin receptor-targeting (TfR) RNA aptamer conjugated to DSPE lipid that leads to an unprecedented effective uptake in the brain, with brain-to-serum ratios up to 6.5 in mice. This result is superior to recently published values of < 1 for antibody conjugates and nanovesicles, pointing to a successful combined effect of the increased lipophilicity and TfR targeting with the new RNA aptamer that our conjugate provides. Using fluorescence whole body imaging, polymerase-chain reaction (PCR) and fluorescence in situ hybridization, we confirm that the new conjugate delivers high amounts of DNA oligonucleotide to brains of Balb/cJ mice, and it is effective in human cells. There is no acute toxicity as verified with histopathological assessment of mice organs. The combination of properties demonstrated by our new conjugate makes it a highly potent delivery tool that can be applied in therapy of brain diseases incl. glioblastoma, neurogenerative diseases, and a broad range of brain infections.}, archive = {J_ANGEW}, author = {Min-sun Song and Adrian H. Bustos and Lise Bastue and Justas Mikutavicius and Piotr Swiderski and Kelly J. Clemens and Nagy Habib and John Rossi and Kira Astakhova}, doi = {10.1002/anie.202500247}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500247}, shortjournal = {Angew. Chem. Int. Edit.}, title = {New transferrin receptor-targeting conjugate effectively delivers DNA to mouse brain}, volume = {64}, year = {2025}, }
• (2025). Application of molecular ferroelectric in photocatalytic selective oxidization of C(sp3)─H bonds. ANGEW, 64(24), e202500176. (www)

  @article{ , abstract = {Molecular ferroelectrics utilize metal nodes and organic groups as catalytic active sites, with the surrounding ferroelectric polarization significantly enhancing catalytic activity and showcasing tremendous application potential. However, their application in photocatalysis remains underexplored. This study presents the first investigation of the molecular perovskite ferroelectric CuCl 4 -[R-MPA] (MPA = β-methylphenethylamine) as a photocatalyst for alkane oxidation. Under the combined effects of light and ultrasound, this catalyst exhibited a notable turnover number (TON) of 6286 ± 491, which is 10 4 times higher than that of inorganic ferroelectrics like barium titanate (BaTiO 3 ). The molecular ferroelectric exhibits excellent recyclability, good functional group tolerance, and broad substrate applicability. Mechanistic studies indicate that the built-in electric field within the molecular ferroelectric facilitates the separation of photo-generated charge carriers, thereby enhancing its ferroelectric photocatalytic activity. Electron paramagnetic resonance (EPR) results further reveal that the synergistic effects of light and ultrasound effectively generate reactive oxygen species. These findings underscore the unique advantages of molecular ferroelectrics compared to rigid inorganic counterparts, including their distinctive structural features and finely tunable catalytic performance, highlighting their potential for developing homogeneous, precisely active sites and efficient photocatalysts. This research lays the foundation for the broader application of molecular ferroelectrics in the field of photocatalysis.}, archive = {J_ANGEW}, author = {Huihui Hu and Rong Liu and Yan-Bing Zhu and Tai-Ting Sha and Xiao-Xing Cao and Zi-Jie Feng and Hao-Ran Ji and Qiang Pan and Ren-Gen Xiong and Yu-Meng You}, doi = {10.1002/anie.202500176}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500176}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Application of molecular ferroelectric in photocatalytic selective oxidization of C(sp3)─H bonds}, volume = {64}, year = {2025}, }
• (2025). A method for constructing nucleosome arrays with spatially defined histone PTMs and DNA damage. ANGEW, 64(24), e202500162. (www)

  @article{ , abstract = {DNA damage repair mechanisms, such as base excision repair (BER), safeguard cells against genotoxic agents that cause genetic instability and diseases, including cancer. In eukaryotic nuclei, DNA within nucleosome arrays is less accessible to repair factors than naked DNA owing to the structural constraints of chromatin. Histone acetylation is crucial for loosening the chromatin structure and facilitating access to damaged DNA, yet its effects—particularly in histone globular domains—on BER in nucleosome arrays remain unexplored. Herein, we employ an abiotic/enzymatic hybrid catalyst system (ABEHCS) and a plug-and-play strategy to regioselectively introduce histone acetylation and deoxycytidine-to-deoxyuridine DNA damage. This approach enables the construction of nucleosome arrays with diverse spatial configurations of histone acetylation and DNA lesions, similar to those found in living organisms. Our findings reveal that H3K56 acetylation in the histone globular domain enhances BER efficiency mediated by UDG and APE1 in nucleosome arrays, contingent upon the spatial relationship between H3K56Ac and the DNA damage site.}, archive = {J_ANGEW}, author = {Ziyun Liu and Siqi Xi and Lauren A. McGregor and Kenzo Yamatsugu and Shigehiro A. Kawashima and Jonathan T. Sczepanski and Motomu Kanai}, doi = {10.1002/anie.202500162}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A method for constructing nucleosome arrays with spatially defined histone PTMs and DNA damage}, volume = {64}, year = {2025}, }
• (2025). Acridine-substituted-centronucleus nonfullerene acceptors enables organic solar cells with over 20% efficiency with low nonradiative recombination loss. ANGEW, 64(24), e202500129. (www)

  @article{ , abstract = {In this work, we propose a novel strategy of introducing luminescent acridine units for central nuclear substitution in quinoxaline-based acceptor molecules (named AQx- o -Ac and AQx- m -Ac) to enhance their photoluminescence quantum yields (PLQY), which can effectively improve the electroluminescent quantum efficiency (EQE EL ) of OSCs and thereby suppress Δ E nr . In addition, the substituted acridine unit accelerates molecular aggregation and optimizes molecular crystallization, effectively alleviating the static disorder of acceptor molecules and facilitating charge extraction and transport in OSCs. As a result, the PM6:AQx- m -Ac binary OSCs achieve an excellent PCE of 18.64% with an exceptionally low Δ E nr of 0.166 eV. To the best of our knowledge, a Δ E nr of 0.166 eV represents the lowest value reported for OSCs achieving PCEs over 18 %. Finally, the acceptor AQx- m -Ac is incorporated into PM6:eC9 blend as the third component, and the optimal ternary device produces a superior PCE of 20.28%. This work highlights the potential of promoting luminescence for suppressing nonradiative energy loss and charts a viable path for upcoming breakthrough in high-efficiency organic photovoltaics.}, archive = {J_ANGEW}, author = {Jinfeng Liu and Xiaopeng Duan and Junjie Zhang and Zhongwei Ge and Liming Liu and Jiawei Qiao and Yuxuan Li and Zhaozhao Bi and Huotian Zhang and Jiaxin Gao and Jun Yan and Sha Liu and Jianqi Zhang and Zheng Tang and Xiaotao Hao and Wei Ma and Feng Gao and Yanming Sun}, doi = {10.1002/anie.202500129}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500129}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Acridine-substituted-centronucleus nonfullerene acceptors enables organic solar cells with over 20% efficiency with low nonradiative recombination loss}, volume = {64}, year = {2025}, }
• (2025). Square planar Ru(iPr2PCH2CH2NH)2 and its role in fast and selective catalytic Amine–Borane dehydropolymerization to form high molecular weight polyaminoboranes. ANGEW, 64(24), e202500019. (www)

  @article{ , abstract = {Addition of t BuOK to orange RuCl 2 ( i Pr 2 PCH 2 CH 2 NH 2 ) 2 forms the pink, square planar, Ru(II) complex Ru( i Pr 2 PCH 2 CH 2 NH) 2 . This is an active catalyst (ToF 250 s −1 ) for the dehydropolymerization of H 3 B·NMeH 2 to give high molecular weight polyaminoborane, [H 2 BNMeH] n ( M n = 138 700 g mol −1 ) at low loadings (0.03 mol%). An induction period observed is due to the initial formation of a hydroxy-hydride species, Ru( i Pr 2 PCH 2 CH 2 NH 2 ) 2 (OH)(H), prior to fast turnover.}, archive = {J_ANGEW}, author = {Mathew J. Cross and M. Arif Sajjad and Stuart A. Macgregor and Andrew S. Weller}, doi = {10.1002/anie.202500019}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202500019}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Square planar Ru(iPr2PCH2CH2NH)2 and its role in fast and selective catalytic Amine–Borane dehydropolymerization to form high molecular weight polyaminoboranes}, volume = {64}, year = {2025}, }
• (2025). Interfacial chemistry in functional hydrogel coatings. ANGEW, 64(24), e202425552. (www)

  @article{ , abstract = {Functional hydrogel coatings can endow the underlying substrate with excellent surface properties, such as anti-fouling, anti-fogging, anti-bacterial, anti-abrasion, lubrication, and controllable drug delivery, while hardly changing the mechanical properties of the substrate. Through elaborate interface engineering, hydrogel coatings with high interfacial toughness and controllable thickness have been successfully constructed on different substrate surfaces for widespread applications. In this review, we present a comprehensive overview of the current research progress in functional hydrogel coatings and the associated interfacial chemistry. First, the interfacial interactions and mechanisms between hydrogel coatings and substrates are discussed. Next, the preparation methods for hydrogel coatings are systematically summarized, with a focus on the involved critical chemical groups/reactions and their respective advantages and disadvantages. Finally, we highlight the challenges from the perspective of large-scale preparation, long-term stability, and multifunctionality, and provide a glimpse into future opportunities, hoping to promote the transformation of functional hydrogel coatings from foundational research to industrial applications.}, archive = {J_ANGEW}, author = {Xizi Wan and Mingqian Liu and Feilong Zhang and Li-Ping Xu and Shutao Wang}, doi = {10.1002/anie.202425552}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202425552}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial chemistry in functional hydrogel coatings}, volume = {64}, year = {2025}, }
• (2025). Selective leaflet-anchored DNA nanoprobes for simultaneous monitoring of juxta-plasma membrane environments. ANGEW, 64(24), e202425335. (www)

  @article{ , abstract = {The cell membrane functions as a bidirectional interface that coordinates the selective transport of substances and information between the interior and exterior of the cell. Simultaneous monitoring of both the inner and outer local environments surrounding this lipid bilayer is crucial for elucidating various cellular activities but significantly challenged by the lack of technologies capable of precisely engineering biosensing probes on both membrane leaflets. In this work, by developing fusogenic nanoliposomes with high cell fusion efficiency, we successfully anchored amphiphilic DNA tetrahedral probes onto the inner leaflet of the plasma membrane. By integrating this with the direct anchoring of amphiphilic probes on the outer leaflet, we achieved precise functionalization of both leaflets of the cell membrane, thus enabling simultaneous monitoring of localized targets within their respective juxta-plasma membrane environments, avoiding signal contamination caused by the optical diffraction limit. Using selectively dual-leaflet-anchored tetrahedral DNAzyme probes, we revealed that the transmembrane ion channel SLC41A1 synergistically modulated the influx of Na + and the efflux of Mg 2+ in live cells. With a modular design, this membrane-anchored DNA nanoplatform can be readily extended for the study of bilateral interface-dominant cellular processes, shifting the paradigm toward a more localized and subtle perspective.}, archive = {J_ANGEW}, author = {Yao He and Jie Lin and Fandi Wu and Yong-Hao Ma and Zhaoyang Wang and Hui Wu and Zhimin Wang and Nachuan Wen and Yutong Zhang and Wenfei Guo and Yulin Du and Weihong Tan and Liping Qiu}, doi = {10.1002/anie.202425335}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202425335}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective leaflet-anchored DNA nanoprobes for simultaneous monitoring of juxta-plasma membrane environments}, volume = {64}, year = {2025}, }
• (2025). A photoactivatable plasma membrane probe based on a self-triggered photooxidation cascade for live cell super-resolution microscopy. ANGEW, 64(24), e202425276. (www)

  @article{ , abstract = {Super-resolution imaging based on the localization of single emitters requires a spatio-temporal control of the ON and OFF states. To this end, photoactivatable fluorophores are adapted as they can be turned on upon light irradiation. Here, we present a concept called self-triggered photooxidation cascade (STPC) based on the photooxidation of a plasma membrane-targeted leuco-rhodamine (LRhod-PM), a non-fluorescent reduced form of a rhodamine probe. Upon visible light irradiation the small number of oxidized rhodamines, Rhod-PM, acts as a photosensitizer to generate singlet oxygen capable of oxidizing the OFF state LRhod-PM thereby switching it to its ON state. We showed that this phenomenon is kinetically favored by a high local concentration and propagates quickly when the probe is embedded in membrane bilayers. In addition, we showed that the close proximity of the dyes favors the photobleaching. At the single-molecule level, the concomitant activation/bleaching phenomena allow reaching a single-molecule blinking regime enabling single-molecule localization microscopy for super-resolution of live cellular membranes and their thin processes including filopodia and tuneling nanotubes.}, archive = {J_ANGEW}, author = {Sonia Pfister and Valentine Le Berruyer and Kyong Fam and Mayeul Collot}, doi = {10.1002/anie.202425276}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202425276}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A photoactivatable plasma membrane probe based on a self-triggered photooxidation cascade for live cell super-resolution microscopy}, volume = {64}, year = {2025}, }
• (2025). DNA framework-ensembled aptamers enhance fluid stability in circulating tumor cells capture for tumor treatment evaluation. ANGEW, 64(24), e202425252. (www)

  @article{ , abstract = {The recognition and binding via receptor-ligand interactions on cell membranes often weaken in complex environments, such as whole blood samples from cancer patients, making disease diagnosis and treatment evaluation unfavorable. Constructing multivalent ligands with sufficient fluid stability in complex environments remains a challenge. Herein, we develop a tetrahedral DNA framework (TDF) ensembled multivalent aptamers (TEA n , n = 1–3) with programmable ligands size, enabling efficient capture of circulating tumor cells (CTCs) and accurate monitoring of clinical treatment progress. The precisely structured TEA n ensures the size-matching and cooperative hybridization with epithelial cell adhesion molecule (EpCAM) on cell membrane. Compared to traditional aptamer approach, the dissociation constants (K d ) of TEA 3 exhibits ∼20-fold growth in serum due to its precise size and rigid DNA framework. This high-affinity interaction significantly enhances capture efficiency by improving fluid stability of TEA n and magnetic beads complex in complex environment. In addition, this CTC detection strategy is applied for clinical tumor treatment evaluation and progress monitoring in liver cancer patient samples, achieving an accuracy of ∼83.3% in classifying patients as complete or partial responses (CR/PR). Overall, this strategy will strongly promote potential clinical application of DNA framework for cancer diagnosis and disease progression monitoring.}, archive = {J_ANGEW}, author = {Yirong Chen and Fan Li and Shuyang Zhang and Feng Liu and Chenzhou Mao and Min Li and Jinhua Jiang and Yueyue Zhang and Chunhai Fan and Xiaolei Zuo}, doi = {10.1002/anie.202425252}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202425252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {DNA framework-ensembled aptamers enhance fluid stability in circulating tumor cells capture for tumor treatment evaluation}, volume = {64}, year = {2025}, }
• (2025). Effect of alternating polarity in electrochemical olefin hydrocarboxylation. ANGEW, 64(24), e202424865. (www)

  @article{ , abstract = {The electrochemical generation of radical anions from feedstock olefins offers a selective and efficient route for synthesizing commodity chemicals and pharmaceutical precursors via hydrofunctionalization. Traditional methods for electrochemical olefin hydrofunctionalization, for example, hydrocarboxylation, rely on anion intermediates and follow an electrochemical–chemical–electrochemical–chemical (ECEC) mechanism involving olefin reduction, carboxylation, further reduction, and protonation. Enhancing terminal carboxylate selectivity often requires a proton source, reducing functional group tolerance and favoring proton reduction over olefin reduction. Alternating polarity, a nascent technique in organic electrochemistry, can improve product selectivity by influencing electron transfer rates and electrode surface species. Herein, we report the use of alternating polarity to selectively generate radical anions from styrene derivatives, using electrochemical hydrocarboxylation as a model. This approach shifts the mechanism to an electrochemical–chemical–chemical (ECC) pathway, where the final step involves hydrogen atom transfer. We showcase how alternating polarity modulates product selectivity, yield, and material decomposition, offering new insights into how alternating polarity can advance olefin functionalization by enabling more controlled and selective reaction pathways.}, archive = {J_ANGEW}, author = {Stella A. Fors and Yong Jia Yap and Christian A. Malapit}, doi = {10.1002/anie.202424865}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202424865}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Effect of alternating polarity in electrochemical olefin hydrocarboxylation}, volume = {64}, year = {2025}, }
• (2025). Sprayed microdroplets architect a polyoxometalate framework. ANGEW, 64(24), e202424745. (www)

  @article{ , abstract = {Although many past attempts have utilized micron-sized droplets for breaking and forming organic bonds, their potential in promoting inorganic bond formation reactions remains largely unexplored. We report a promising approach to synthesizing a tungsten-based Lindqvist-type polyoxometalate (POM) in various organic and aqueous microdroplets under ambient conditions, eliminating the traditional need for hazardous or corrosive chemicals and high-boiling solvents. When aerosolized, a simple tungstate (WO 4 2− ) solution spontaneously produces a metal-oxo cluster (W 6 O 19 2− ), a valuable POM with broad applications, achieving yields up to 99% in less than a millisecond. Mass spectrometric detection of reactive intermediates unraveled the nucleation mechanism in microdroplets, leading to the formation of polyoxotungstate, which was then further characterized by X-ray crystallography. Empirical observations collectively suggest that rapid solvent evaporation and subsequent enrichment of reactants in the confined volume of microdroplets likely facilitate the growth of the POM through partial solvation at the air–liquid interface.}, archive = {J_ANGEW}, author = {Abhijit Nandy and Gajiram Murmu and Anitesh Rana and Sumit Saha and Shibdas Banerjee}, doi = {10.1002/anie.202424745}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202424745}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sprayed microdroplets architect a polyoxometalate framework}, volume = {64}, year = {2025}, }
• (2025). Structurally engineering multi-shell hollow zeolite single crystals via defect-directed oriented-kinetics transformation and their heterostructures for hydrodeoxygenation reaction. ANGEW, 64(24), e202424690. (www)

  @article{ , abstract = {Single-crystalline multi-shell hollow porous materials with high compartment capacity, large active surface area, and superior structural stability are expected to unlock tremendous potential across diverse critical applications. However, their synthetic methodology has not yet been well established. Here, we develop a defect-directed oriented-kinetics transformation approach to prepare multi-shell hollow aluminosilicate ZSM-5 zeolite ( MFI ) crystals with single-crystalline feature, hierarchical macro-/mesoporosity, controllable shell number, and high structural stability. The methodology lies in the creation of zeolite precursors consisting of multiple inhomogeneous layers with gradient-distributed defects along the [100] and [010] directions and irregularly discrete defects-rich regions along the [001] direction via continuous epitaxial growth. Subsequently, the locations with more defects could be preferentially etched to form voids or mesopores, meanwhile oriented recrystallization interconnects the nanoshells into a unified architecture along the [001] direction. Benefiting from the easily accessible bifunctional metal/acid sites and the capability for reactant accumulation, the resultant multi-shell hollow Ni-loaded zeolite catalysts show significantly enhanced catalytic activity in the hydrodeoxygenation of stearic acid into liquid fuels. The insight gained from this systematic study will facilitate the rational design and synthesis of diverse multi-shell hollow structured single-crystalline porous materials for a broad range of potential applications.}, archive = {J_ANGEW}, author = {Guangrui Chen and Peihong She and Ji Han and Junyan Li and Ge Tian and Yuanbo Sun and Yanjing Gao and Guoju Yang and Zhenheng Diao and Buyuan Guan and Jihong Yu}, doi = {10.1002/anie.202424690}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202424690}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structurally engineering multi-shell hollow zeolite single crystals via defect-directed oriented-kinetics transformation and their heterostructures for hydrodeoxygenation reaction}, volume = {64}, year = {2025}, }
• (2025). Efficient semitransparent organic solar modules with exceptional diurnal stability through asymmetric interaction induced by symmetric molecular structure. ANGEW, 64(24), e202424287. (www)

  @article{ , abstract = {The symmetry-breaking design strategy of nonfullerene acceptor can improve the performance of semitransparent organic solar cells (ST-OSCs). However, no report exists on the “asymmetric molecular interaction” induced by symmetric molecular structure in nonfullerene acceptors. Herein, we showcase that 2D fluorophenyl outer groups in symmetric 4FY promote dipole-driven self-assembly through asymmetric molecular interactions, resulting in a tighter packed structure than Y6 with the same symmetric geometry. Such unique properties lead to high-performance layer-by-layer OSCs, accompanied by simultaneously reduced energy and recombination losses and improved charge-related characteristics. ST-OSCs based on PCE10-2F/4FY achieve notable power conversion efficiency (PCE) of 10.81%, average visible transmittance of 45.43%, and light utilization efficiency (LUE) of 4.91%. Moreover, exceptional diurnal cycling stability is observed in the ST-OSCs based on PCE10-2F/4FY with much prolonged T 80 up to 134 h, which is about 17 times greater than the reference PCE10-2F/Y6. Lastly, we fabricate highly efficient semitransparent organic solar modules based on PCE10-2F/4FY (active area of 18 cm 2 ), which shows PCE of 6.78% and the highest LUE of 3.10% to date for all-narrow bandgap semitransparent organic solar modules. This work demonstrates that asymmetry-driven molecular interactions can be leveraged to fabricate large-area ST-OSCs that are efficient and stable under realistic operating conditions.}, archive = {J_ANGEW}, author = {Sangjin Yang and Xuexiang Huang and Yongjoon Cho and Sungmo Koo and Yanni Ouyang and Zhe Sun and Seonghun Jeong and Thi Le Huyen Mai and Wonjun Kim and Lian Zhong and Shanshan Chen and Chunfeng Zhang and Hee-Seung Lee and Seong-Jun Yoon and Lie Chen and Changduk Yang}, doi = {10.1002/anie.202424287}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202424287}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient semitransparent organic solar modules with exceptional diurnal stability through asymmetric interaction induced by symmetric molecular structure}, volume = {64}, year = {2025}, }
• (2025). Development of an automated workflow for screening the assembly and Host–Guest behavior of metal-organic cages towards accelerated discovery. ANGEW, 64(24), e202424270. (www)

  @article{ , abstract = {Metal-organic cages (MOCs) are a class of self-assembled materials with promising applications in chemical purifications, sensing, and catalysis. Their potential is, however, hampered by challenges in the targeted design of MOCs with desirable properties. MOC discovery is thus often reliant on trial-and-error approaches and brute-force manual screening, which are time-consuming, costly, and material-intensive. Translating the synthesis and property screening of MOCs to an automated workflow is therefore attractive, to both accelerate discovery and provide the datasets crucial for data-led approaches to accelerate MOC discovery and to realize their targeted properties for specific applications. Here, an automated workflow for the streamlined assembly and property screening of MOCs was developed, incorporating automated high-throughput screening of variables pertinent to MOC synthesis, data curation and automated analysis, and development of a host–guest assay to rapidly assess binding behavior. Computational modelling supplemented this automated experimental workflow for post priori rationalization of experimental outcomes. This study lays the groundwork for future large-scale MOC screening: from a relatively modest screen of 24 precursor combinations under one set of reaction conditions, 3 clean MOC species were identified, and subsequent screening of their host–guest behavior highlighted trends in binding and the identification of potential applications in molecular separations.}, archive = {J_ANGEW}, author = {Annabel R. Basford and Aaron H. Bernardino and Paula C. P. Teeuwen and Benjamin D. Egleston and Joshua Humphreys and Kim. E. Jelfs and Jonathan R. Nitschke and Imogen A. Riddell and Rebecca L. Greenaway}, doi = {10.1002/anie.202424270}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202424270}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development of an automated workflow for screening the assembly and Host–Guest behavior of metal-organic cages towards accelerated discovery}, volume = {64}, year = {2025}, }
• (2025). Magnetically induced catalysis: Definition, advances, and potential. ANGEW, 64(24), e202424151. (www)

  @article{ , abstract = {The rapidly growing importance of electrification in the chemical industry opens room for disruptive innovations regarding energy input into catalytic processes. Energy efficiency and dynamics of renewable energy supplies represent important challenges, but the design of catalytic systems to cope with such new frameworks may also stimulate the discovery of new catalyst materials and reaction pathways. In this context, many opportunities arise when catalysts are activated in a rapid, localized, and energy-efficient manner. Among the various concepts to achieve adaptivity in catalysis, magnetic induction heating applied directly at the catalyst or in vicinity of the active site has gained increasing attention recently. In this Scientific Perspective, we provide a coherent framework to the emerging field of catalysis using magnetic fields—and in particular alternating current magnetic fields—to activate catalytic materials and define it as magnetically induced catalysis . Promising approaches and selected examples are described to illustrate the scientific concept and to highlight its broad potential for innovation in catalysis from laboratory to industrial scale.}, archive = {J_ANGEW}, author = {A. Bordet and W. Leitner and B. Chaudret}, doi = {10.1002/anie.202424151}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202424151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Magnetically induced catalysis: Definition, advances, and potential}, volume = {64}, year = {2025}, }
• (2025). Synthesis and characterization of photoswitchable covalent ligands for the β2-adrenoceptor. ANGEW, 64(24), e202424038. (www)

  @article{ , abstract = {The β 2 -adrenergic receptor (β 2 AR) is a critical target for the treatment of airway diseases such as asthma or chronic obstructive pulmonary disease (COPD). To better understand its mechanism of action and study its dynamics, photoswitchable ligands provide a distinct advantage due to their ability to be activated with high spatiotemporal control. In this study, we developed a series of molecular tools featuring different combinations of pharmacophores, covalent warheads, and linker lengths. These compounds were characterized using highly specific assay protocols to evaluate their covalent binding capabilities, with the goal of identifying optimal covalently-bound photoswitches. Among these, the covalently-bound photoswitchable receptor agonist 6 exhibited a significant functional switch. To gain deeper insight into the binding thermodynamics and kinetics of this molecular tool, as well as the molecular determinants involved, we performed metadynamics (MetaD) simulations and analyzed their results using a Markov State Model (MSM) obtained by applying the Maximum Caliber (MaxCal) principle to the MetaD-derived free energies. These studies suggest that photoswitching of compound 6 occurs within the binding pocket of the β 2 AR. Consequently, compound 6 holds promise as a valuable tool for investigating β 2 AR activation kinetics and dynamics with high accuracy, thereby facilitating high-resolution biophysical studies.}, archive = {J_ANGEW}, author = {Ulrike Wirth and Eduard Neu and Davide Provasi and Steffen Feustel and Maximilian F. Schmidt and Harald Hübner and Dorothée Weikert and Marta Filizola and Burkhard König and Peter Gmeiner}, doi = {10.1002/anie.202424038}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202424038}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and characterization of photoswitchable covalent ligands for the β2-adrenoceptor}, volume = {64}, year = {2025}, }
• (2025). Functionalized cyclic poly(α-hydroxy acids) via controlled ring-opening polymerization of O-carboxyanhydrides. ANGEW, 64(24), e202423973. (www)

  @article{ , abstract = {Linear poly(α-hydroxy acids) are important degradable polymers, and they can be efficiently prepared by ring-opening polymerization of O-carboxyanhydrides with pendant functional groups. However, attempts to prepare cyclic poly(α-hydroxy acids) have been plagued by side reactions, including epimerization and uncontrolled intramolecular chain transfers or termination, that prevent the synthesis of high-molecular-weight stereoregular cyclic polyesters. Herein, we report a scalable method for the synthesis of high-molecular-weight (>100 kDa) stereoregular functionalized cyclic poly(α-hydroxy acids) by means of controlled polymerization of O-carboxyanhydrides using a catalytic system consisting of a lanthanum complex with a sterically bulky ligand and a manganese silylamide. Additionally, using this system, we could readily prepare cyclic block poly(α-hydroxy acids) by means of sequential addition of O-carboxyanhydrides. The obtained cyclic polyesters and their cyclic block copolyesters exhibit distinctive physicochemical properties—including elevated phase transition temperature, improved toughness, and reduced viscosity—compared to their linear counterparts.}, archive = {J_ANGEW}, author = {Ziyu Huo and Xiaoyu Xie and Nadim Mahmud and Joshua C. Worch and Rong Tong}, doi = {10.1002/anie.202423973}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202423973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functionalized cyclic poly(α-hydroxy acids) via controlled ring-opening polymerization of O-carboxyanhydrides}, volume = {64}, year = {2025}, }
• (2025). Alcohol activation by benzodithiolylium for deoxygenative alkylation driven by photocatalytic energy transfer. ANGEW, 64(24), e202423795. (www)

  @article{ , abstract = {The 1,3-benzodithiolylium (BDT) cation was identified as an efficient hydroxyl-activating reagent for the photocatalytic deoxygenative radical functionalization of alcohols in the absence of any electron transfer process. A series of unprecedented photocatalytic energy transfer (EnT)-driven deoxygenative radical coupling reactions of alcohols with bifunctional oxime carbonates have been developed based on the activation by BDT. Nickel-catalyzed radical sorting followed by C(sp 3 )─C(sp 3 ) bond construction facilitates the heteroselective cross-coupling of two distinct alkyl radicals originating from parallel radical relays. These reactions allow the versatile synthesis of diverse nitrogen-containing molecules, including amino acid derivatives, imines, nitriles, and pyrrolines, by using ubiquitous alcohols as regiodefined alkyl building blocks.}, archive = {J_ANGEW}, author = {Bin-Qing He and Lu Zhao and Jun Zhang and Wen-Hui Bao and Mingjun Yang and Xuesong Wu}, doi = {10.1002/anie.202423795}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202423795}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alcohol activation by benzodithiolylium for deoxygenative alkylation driven by photocatalytic energy transfer}, volume = {64}, year = {2025}, }
• (2025). Manipulation of chemistry and biology with visible light using tetra-ortho-substituted azobenzenes and azonium ions. ANGEW, 64(24), e202423506. (www)

  @article{ , abstract = {Molecular photoswitches are used for precise and reversible control over the properties and function of chemical, biological and material systems, offering exceptional spatiotemporal control. Their current development focuses on enabling operation with non-damaging and deep tissue penetrating visible/near-IR light. In this context, tetra- ortho -substituted azobenzenes and azonium ions play a leading role, thanks to their unique photophysical properties and easily modifiable structure. However, it is only recently that synthetic approaches to those sterically demanding systems have been established and their structure-photochemistry relations have been understood to provide general rules for their tuning to a given application. In this review, we provide a comprehensive overview of this family of molecular photoswitches, providing an analysis of their photophysical properties, followed by a discussion of the available synthetic methodologies. Finally, we showcase the versatility of tetra- ortho -substituted azobenzenes and azonium ions for enabling light-control in biological and material sciences, providing multiple insights for future applications.}, archive = {J_ANGEW}, author = {Francesca Cardano and Rosa Márquez García and Wiktor Szymanski}, doi = {10.1002/anie.202423506}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202423506}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulation of chemistry and biology with visible light using tetra-ortho-substituted azobenzenes and azonium ions}, volume = {64}, year = {2025}, }
• (2025). High-efficiency ion transport in ultrathin 3D covalent organic framework nanofluidics. ANGEW, 64(24), e202423073. (www)

  @article{ , abstract = {High-efficiency ion transport is essential for both biological and nonbiological processes, including the regulation of cell homeostasis, energy conversion, and mass transfer in chemical industry. Nanofluidic channels are considered ideal platforms for delicate control of ion transport in their unique nanoconfinement, yet currently reported 1D and 2D nanofluidics are subjected to elevated transport resistance due to discontinuous and random channels. Here, we engineer ultrathin, 3D covalent organic framework (3D-COF) nanofluidics featuring continuously interpenetrated pathways and well-ordered pore arrangements, demonstrating superior ion conductance. The energy barrier for ion transport across 3D-COF nanofluidics is exceptionally low, suggesting ultrafast and low-resistance ion movements. Theoretical calculations indicate that 3D-COF nanofluidics facilitate group adsorption to anions, leading to high energy barriers for anion mobility, thus enhancing ion selectivity and high-throughput cation transport. In osmotic energy applications, 3D-COF nanofluidics achieve a power density of 217.7 W m −2 with artificial seawater and river water, potentially scalable to 1238.2 W m −2 under a 500-fold salinity gradient. The proposed 3D-COF nanofluidics offer new avenues for desalination and ion/molecular separation.}, archive = {J_ANGEW}, author = {Haoyang Ling and Qingchen Wang and Zidi Yan and Xuanze Li and Kehan Zou and Yaoxu He and Ke Li and Yanglansen Cui and Tianchi Liu and Weipeng Chen and Huaqing Du and Yang Liu and Weiwen Xin and Xiang-Yu Kong and Lei Jiang and Liping Wen}, doi = {10.1002/anie.202423073}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {24}, pages = {e202423073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-efficiency ion transport in ultrathin 3D covalent organic framework nanofluidics}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Non-carbonized pd single-atom catalyst supported on lignin-functionalized phenolic resin for potent catalytic transfer hydrogenation of lignin-derived aldehydes. ANGEW, 64(23), e202582301. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582301}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202582301}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Non-carbonized pd single-atom catalyst supported on lignin-functionalized phenolic resin for potent catalytic transfer hydrogenation of lignin-derived aldehydes}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Biomimetic hierarchical construction of anti-tumor polyoxopalladates for cancer therapy (Angew. chem. int. ed. 23/2025). ANGEW, 64(23), e202510019. (www)

  @article{ , archive = {J_ANGEW}, author = {Yue Zhao and Zheran Liu and Zijian Qin and Qinlong Wen and Jing Du and Xiang-Yu Ren and Chao-Qin Chen and Xingchen Peng and Ulrich Kortz and Peng Yang}, doi = {10.1002/anie.202510019}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202510019}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Biomimetic hierarchical construction of anti-tumor polyoxopalladates for cancer therapy (Angew. chem. int. ed. 23/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Hydrogen binding energy is insufficient for describing hydrogen evolution on single-atom catalysts (Angew. chem. int. ed. 23/2025). ANGEW, 64(23), e202509579. (www)

  @article{ , archive = {J_ANGEW}, author = {Songbo Ye and Fangzhou Liu and Fangxin She and Jiaxiang Chen and Di Zhang and Akichika Kumatani and Hitoshi Shiku and Li Wei and Hao Li}, doi = {10.1002/anie.202509579}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202509579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Hydrogen binding energy is insufficient for describing hydrogen evolution on single-atom catalysts (Angew. chem. int. ed. 23/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Avoiding the kauzmann paradox via interface-driven divergence in states (Angew. chem. int. ed. 23/2025). ANGEW, 64(23), e202509577. (www)

  @article{ , archive = {J_ANGEW}, author = {Andrew Martin and Jason R. Green and Martin Thuo}, doi = {10.1002/anie.202509577}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202509577}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Avoiding the kauzmann paradox via interface-driven divergence in states (Angew. chem. int. ed. 23/2025)}, volume = {64}, year = {2025}, }
• (2025). Back cover: Quantum mechanical tunnelling probes with redox cycling for ultra-sensitive detection of biomolecules (Angew. chem. int. ed. 23/2025). ANGEW, 64(23), e202508478. (www)

  @article{ , archive = {J_ANGEW}, author = {Long Yi and Tao Jiang and Ren Ren and Ji Cao and Joshua B. Edel and Aleksandar P. Ivanov and Longhua Tang}, doi = {10.1002/anie.202508478}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202508478}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Quantum mechanical tunnelling probes with redox cycling for ultra-sensitive detection of biomolecules (Angew. chem. int. ed. 23/2025)}, volume = {64}, year = {2025}, }
• (2025). Robert luxenhofer. ANGEW, 64(23), e202507493. (www)

  @article{ , archive = {J_ANGEW}, author = {Robert Luxenhofer}, doi = {10.1002/anie.202507493}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202507493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robert luxenhofer}, volume = {64}, year = {2025}, }
• (2025). Marvin parasram. ANGEW, 64(23), e202507491. (www)

  @article{ , archive = {J_ANGEW}, author = {Marvin Parasram}, doi = {10.1002/anie.202507491}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202507491}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Marvin parasram}, volume = {64}, year = {2025}, }
• (2025). Geminiarene-based charge-transfer cocrystals with dichromatic variants and stimuli-responsive structural interconversion. ANGEW, 64(23), e202506549. (www)

  @article{ , abstract = {The construction of stimuli-responsive charge-transfer (CT) cocrystals is a challenging frontier in organic crystal engineering. Here, we introduce a gemini CT cocrystal system with dichromatic stimuli-responsiveness by utilizing the unique dual/gemini conformational feature of geminiarene. Geminiarene binds with the electron-deficient guest 1,2,4,5-tetracyanobenzene through exo-wall interactions to form two types of gemini CT cocrystals with distinct colors. Single-crystal structures, along with theoretical calculations and spectral analyses, reveal that the color differences are primarily due to the dual molecular conformations of geminiarene and their distinct electronic properties. Notably, the gemini CT cocrystal system can be used to develop a novel dichromatic sensing material capable of distinguishing commonly used organic solvents. Moreover, the stimuli-responsive interconversion between the two conformations of geminiarene enables a loop-locked structural transition in the cocrystal system. This work expands CT cocrystal engineering and offers a new strategy for designing intelligent responsive materials for sensing and adsorption applications.}, archive = {J_ANGEW}, author = {Susu Ren and Yu-Xiang Sun and Zi-Yu Wang and Xiang-Shuai Li and Jia-Rui Wu}, doi = {10.1002/anie.202506549}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202506549}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Geminiarene-based charge-transfer cocrystals with dichromatic variants and stimuli-responsive structural interconversion}, volume = {64}, year = {2025}, }
• (2025). Iridium-catalyzed asymmetric allenylic substitution via kinetic resolution enabled by new monodentate ligands. ANGEW, 64(23), e202506350. (www)

  @article{ , abstract = {Iridium-catalyzed asymmetric allenylic substitution represents a useful method for the construction of allenes bearing an allenylic central chirality, but current success has uniformly relied on only one specific chiral bidentate ligand. Herein, we address the limitation by the design of a new type of monodentate ligands leading to not only excellent enantiocontrol in allenylic substitution but also efficient kinetic resolution of α-allenylic alcohols, a new phenomenon never observed before in iridium-catalyzed allenylic substitution. This is also a rare demonstration of the non-enzymatic kinetic resolution of α-allenylic alcohols. A range of highly enantioenriched allenylic diarylmethanes and α-allenylic alcohols could be accessed under mild conditions. Control experiments and DFT studies indicated that this process proceeds by an S N 1 pathway featuring a rate-determining ionization step followed by ligand-controlled enantiodetermining nucleophilic addition. The newly designed rigid and bulky ligands modified from SPHENOL were believed to assemble the key iridium-bound allenylic carbocation intermediate in a different complexation mode, thus serving as the origin of enantiocontrol and the unprecedented kinetic resolution.}, archive = {J_ANGEW}, author = {Youshao Tu and Xiangfeng Lin and Jie Lin and Chaoshen Zhang and Jianwei Sun}, doi = {10.1002/anie.202506350}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202506350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iridium-catalyzed asymmetric allenylic substitution via kinetic resolution enabled by new monodentate ligands}, volume = {64}, year = {2025}, }
• (2025). Electron acceptors based on resonant N─B←N unit with improved exciton dissociation for high-performance short-wavelength infrared organic photodetectors. ANGEW, 64(23), e202506116. (www)

  @article{ , abstract = {Device performance of photodiode-type short-wavelength infrared (SWIR) organic photodetectors (OPDs) is largely limited by poor exciton dissociation. In this work, we reported that downshifted highest occupied molecular orbital energy level ( E HOMO ) and increased electrostatic potential (ESP) of electron acceptor lead to improved exciton dissociation and consequently enhanced SWIR OPD device performance. Tetramers of thiophene-fused 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (TF-BODIPY) unit represent a new kind of electron acceptors with SWIR photoresponse. By endcapping the TF-BODIPY tetramer with electron-deficient pentafluorophenyl groups, we downshift the E HOMO of the electron acceptor by 0.06 eV and increase the ESP of the electron acceptor by 89 meV. As a result, the OPD devices of the electron acceptor exhibit SWIR photoresponse in the wavelength range of 0.3–1.3 µm with a maximum specific detectivity ( D *) of 1.04 × 10 12 Jones and a responsivity ( R ) of 0.16 A W −1 at 1.12 µm. This performance is among the highest reported for SWIR OPDs.}, archive = {J_ANGEW}, author = {Mengyu Liu and Weirong Li and Zhongxiang Peng and Xingxin Shao and Jun Liu and Lixiang Wang}, doi = {10.1002/anie.202506116}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202506116}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron acceptors based on resonant N─B←N unit with improved exciton dissociation for high-performance short-wavelength infrared organic photodetectors}, volume = {64}, year = {2025}, }
• (2025). Correction to “Copper(I) catalysed diboron(4) reduction of nitrous oxide”. ANGEW, 64(23), e202506114. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202506114}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202506114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Copper(I) catalysed diboron(4) reduction of nitrous oxide”}, volume = {64}, year = {2025}, }
• (2025). Engineering heteronuclear dual-metal active sites in ordered macroporous architectures for enhanced C2H4 production from CO2 photoreduction. ANGEW, 64(23), e202506072. (www)

  @article{ , abstract = {Photocatalytic C 2 H 4 synthesis from CO 2 and H 2 O by utilizing solar energy represents a promising sustainable process, yet its efficiency remains significantly limited. Herein, we proposed a dual-engineered strategy integrating 3D ordered macroporous (3DOM) architectures with heteronuclear dual-metal active sites to synergistically promote the photocatalytic C 2 H 4 production. As an example, the Cu/3DOM-In 2 O 3 photocatalyst was synthesized by in situ incorporating Cu single atoms (Cu SAs) into 3DOM In 2 O 3 through a template-assisted pyrolysis process. The strong interaction between Cu SAs and In 2 O 3 resulted in the formation of charge-polarized Cu─In active sites along with abundant oxygen vacancies (O V s). 3DOM architectures serving as special nanoreactors displayed significant advantages in promoting CO 2 enrichment and confining key intermediates, thereby increasing *CO coverage. Meanwhile, the charge-polarized Cu─In active sites effectively mitigated electrostatic repulsion and promoted the formation of *CO + *CHO intermediates, resulting in a thermodynamically spontaneous C─C coupling step. Therefore, the Cu/3DOM-In 2 O 3 photocatalyst exhibited robust CO 2 reduction to C 2 H 4 , achieving high C 2 H 4 evolution rates under various CO 2 concentrations, including pure CO 2 , 10% CO 2 in Ar (simulated flue gas), and 0.04% CO 2 in Ar (simulated air). This work offers a novel strategy for the construction of photocatalysts with tailored microstructures and specific active sites to promote the conversion of CO 2 and H 2 O into multicarbon products.}, archive = {J_ANGEW}, author = {Mao Xu and Qianyu Zhang and Shupeng Wei and Shoujie Liu and Min Zhou and Yanying Zhao and Benxia Li and Yi Xie}, doi = {10.1002/anie.202506072}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202506072}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering heteronuclear dual-metal active sites in ordered macroporous architectures for enhanced C2H4 production from CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Single-step synthesis of a heterometallic [Cu2PdL4]2+ hybrid Metal–Organic coordination cage. ANGEW, 64(23), e202506064. (www)

  @article{ , abstract = {Traditional methods of assembling low-symmetry heterometallic cage architectures are limited to stepwise construction and combinations of inert and labile metal ions, affording complex, anisotropic cage structures by sacrificing synthetic ease. Herein, a heterometallic [Cu 2 PdL 4 ] 2+ lantern-type cage has been assembled in a single self-assembly step through the use of a heteroditopic ligand with two different metal-binding groups. The resultant cage complex is a fusion of two common lantern-type cage motifs—carboxylate-based metal-organic Cu 4 L 4 cages and pyridyl-based Pd 2 L 4 coordination cages. Evidence for heterometallic cage formation in solution was provided by 1 H and diffusion-ordered NMR spectroscopy and electrospray ionization mass spectrometry (ESIMS) data, whereas circular dichroism (CD) spectra confirmed the helical nature of the assembly. The heterometallic cage was then exploited in binding heterotopic guests. It is envisioned that the simple design strategy presented herein will ease the assembly of other structurally complex, low-symmetry cage architectures.}, archive = {J_ANGEW}, author = {Shannon Thoonen and Samuel E. Walker and David L. Marshall and Therese M. Fulloon and Samuel Brandon and Alasdair I. McKay and Martin J. Paterson and Kathleen M. Mullen and James D. Crowley and Kellie L. Tuck and David R. Turner}, doi = {10.1002/anie.202506064}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202506064}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-step synthesis of a heterometallic [Cu2PdL4]2+ hybrid Metal–Organic coordination cage}, volume = {64}, year = {2025}, }
• (2025). Tubular nanostructures from large-pore 2D covalent organic frameworks. ANGEW, 64(23), e202505935. (www)

  @article{ , abstract = {The synthesis of a wavy mesoporous 2D covalent organic framework (COF) with a 6-nm hexagonal pore lattice ( Joa-COF-1 ) is reported. This has been achieved by the synthesis of a terpyrenyl linker of approximately 2.7 nm in length and its subsequent condensation with a 3-connected non-planar cata-hexabenzocoronene. Joa-COF-1 exists as non-covalent tubular domains composed of π-stacked 4 to 5 pores in 2D COF sections that can be separated by mild sonication, resulting in a family of tubular COF nanostructures that combine a 1D morphology with accessible mesopores.}, archive = {J_ANGEW}, author = {Joaquín Almarza and Ian Cardillo-Zallo and Karol Strutyński and Marta Martínez-Abadía and Natalia M. Padial and Carlos Martí-Gastaldo and Manuel Melle-Franco and Andrei N. Khlobystov and Aurelio Mateo-Alonso}, doi = {10.1002/anie.202505935}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505935}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tubular nanostructures from large-pore 2D covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Enhancing circularly polarized luminescence of anthraquinones via J-type supramolecular polymerization. ANGEW, 64(23), e202505776. (www)

  @article{ , abstract = {Circularly polarized luminescence materials based on cost-effective point-chiral luminophores are highly desirable; however, their performance is often hindered by weak exciton–chirality coupling between the luminophore and its adjacent stereocenters. Here, we introduce J-type supramolecular polymerization as an effective strategy to address this challenge. By attaching amide groups to point-chiral anthraquinone luminophores, the formation of directional hydrogen bonds facilitates efficient chirality transfer from peripheral stereocenters to anthraquinones, resulting in supramolecular polymers with amplified chiroptical asymmetry. More importantly, the incorporation of acetylene spacers reduces torsional angle of the anthraquinone core compared to the nonacetylene control compound (1.81° versus 33.4°), promoting J-aggregation and increasing emission intensity. This structural optimization enables the supramolecular polymers to achieve a circularly polarized luminescence brightness of 13.8 M⁻¹cm⁻¹, marking a significant advancement in point-chiral luminophore systems. Furthermore, the integration of Förster resonance energy transfer into these supramolecular polymers allows for the fabrication of color-tunable circularly polarized electroluminescent devices. Overall, J-type supramolecular polymerization represents a promising approach for developing high-performance chiroptical materials by simultaneously optimizing emission dissymmetry and quantum efficiency.}, archive = {J_ANGEW}, author = {Laiwei Gao and Rui Liao and Lei Ao and Yifei Zhang and Jianan Jin and Feng Wang}, doi = {10.1002/anie.202505776}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing circularly polarized luminescence of anthraquinones via J-type supramolecular polymerization}, volume = {64}, year = {2025}, }
• (2025). Nonclassical hydrogen bond-based efficient solid-state organic emitters enabled by a synergistic anion and mechanical bond effect. ANGEW, 64(23), e202505774. (www)

  @article{ , abstract = {Traditional fluorophores often face aggregation-caused quenching (ACQ), limiting their efficacy in high-concentration applications. We demonstrate that a combined effect of anion and mechanical bond can significantly increase fluorescence intensity, up to 14-fold, and a quantum yield of 97.0%. A large number of crystal analyses reveal that this enhancement is primarily driven by nonclassical hydrogen bonds, which stabilize the structure and restrict molecular motion. The versatility of this synergistic effect opens up new avenues for applications, including circularly polarized luminescence (CPL) facilitated by chiral anions and the development of a fluorescence switchable rotaxane shuttle-based stimuli-responsive material.}, archive = {J_ANGEW}, author = {Yi An and Ru Zhou and Ningjin Zhang and Aocheng Chen and Junfei Xing and Shu Zhang and Quan Li}, doi = {10.1002/anie.202505774}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505774}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nonclassical hydrogen bond-based efficient solid-state organic emitters enabled by a synergistic anion and mechanical bond effect}, volume = {64}, year = {2025}, }
• (2025). Fast and autonomous mannosylated nanomotors for dynamic cancer cell targeting. ANGEW, 64(23), e202505717. (www)

  @article{ , abstract = {An attractive strategy in cancer cell therapy is to employ motile nanoparticles that can actively search for their target. Herein, we introduce mannosylated compartmentalized cross-linked enzyme-driven nanomotors (c-CLEnM), which exhibit specific and efficient targeting of Hep G2 cells through elevated autonomous motion. In this design, we constructed biodegradable bowl-shaped stomatocytes encapsulating the enzymes glucose oxidase (GOx) and catalase (CAT) within their nanocavity. A subsequent enzyme crosslinking reaction was performed to guarantee their stability. Furthermore, the c-CLEnM were surface modified with a mannose-functional glycopolymer, enabling binding with receptors expressed on Hep G2 cells. Interestingly, the targeting ligands on the nanomotors not only improved their specificity toward cancer cells but also enhanced motility. Compared to the non-mannosylated nanomotors, mannosylated c-CLEnM exhibited enhanced motion and higher targeting efficiency to cells in glucose-containing ionic environments. The unexpected acceleration in speed resulted from the surface modification of these nanomotors with a glycopolymer layer, which increased the zeta potential and created a shielding effect that mitigated the influence of the surrounding ions. This nanomotor design highlights the synergistic effect of functional glycopolymer modification on cellular uptake, adding an additional level of control to nanomotors for application in cancer therapy.}, archive = {J_ANGEW}, author = {Yuechi Liu and Roberto Terracciano and Jari Scheerstra and Gokhan Yilmaz and Hanglong Wu and Pascal Welzen and Shoupeng Cao and Tania Patino Padial and Loai Abdelmohsen and Jingxin Shao and Bingbing Sun and C. Remzi Becer and Jan C. M. van Hest}, doi = {10.1002/anie.202505717}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505717}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fast and autonomous mannosylated nanomotors for dynamic cancer cell targeting}, volume = {64}, year = {2025}, }
• (2025). Iterative synthesis of dynamic conjugated oligomers displaying length-dependent configuration metastability, state-dependent properties, and helix emergence. ANGEW, 64(23), e202505703. (www)

  @article{ , abstract = {The emergence of structure and function at the mesoscale is critical for the design of complex molecular materials. In this work, we report an iterative liquid-phase construction of precision conjugated oligomers with alternating di- and tetra-arylsubstituted alkene (DAA and TAA) building blocks. Due to the dynamically reversible isomerization of TAA building blocks in the backbone, this system exhibited a complex library of constitutional stereoisomers with configurational metastability, as characterized by HRMS, chiral HPLC, and 2D excitation-emission fluorescence mapping analysis. The dynamic oligomer system exhibits aggregation-induced absorption shifts and state-dependent fluorescence and shows constitutional responses to thermal and light stimuli. During the self-assembly process, mesoscale helicity emerges in the P5 oligomer and evolves into regular helices (40–66 nm pitch) in the P9 oligomer, which can also be tuned by side group modulation. Experimental and computational studies suggest a dynamic transition of conjugated backbone conformations with increasing chain length from linear, rich in trans -alkenes, to twisted with alternating trans - and cis -alkenes, resulting in a stereoregular triangular chain segment for secondary structure generation and property emergence.}, archive = {J_ANGEW}, author = {Qilong Bian and Mengfan Huang and Ying Zhao and Yang Zhang and Chunhua Zhang and Zebing Zeng and Sheng Xie and Ben Zhong Tang}, doi = {10.1002/anie.202505703}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505703}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iterative synthesis of dynamic conjugated oligomers displaying length-dependent configuration metastability, state-dependent properties, and helix emergence}, volume = {64}, year = {2025}, }
• (2025). A Ruthenium(II) complex inhibits BRD4 for synergistic seno- and chemo-immunotherapy in cisplatin-resistant tumor cells. ANGEW, 64(23), e202505689. (www)

  @article{ , abstract = {Drug resistance is a significant challenge for tumor therapy. Activating immunity is an effective method to combat drug-resistant tumors. Utilizing metallic chemotherapeutic agents to induce nonapoptotic programmed cell death is a practical approach to stimulate immunity. Besides, triggering tumor cell senescence, named senotherapy, is also an effective but often ignored method to induce immune responses. Despite some progress, reports on metallic immunotherapeutic stimuli are sparse and mainly delve into the level of organelle targeting, with vague drug–target mechanisms. Here, we report a Ru(II) complex ( Ru2c ) inhibits BRD4 with high affinity at a nanomolar constant. After encapsulation into biotin-DNA cage, Ru2c@biotin-DNA cage was demonstrated to kill drug-resistant cancer cells through a synergistic apoptosis-ferroptosis-senescence pathway, exhibiting 51-fold anticancer activity compared to the commercial inhibitor JQ-1. Ru2c effectively erased drug-resistant tumors and activated innate and acquired immunity in vivo. To the best of our knowledge, Ru2c is the first metal-based BRD4 inhibitor to achieve synergistic seno-immunotherapy and chemo-immunotherapy.}, archive = {J_ANGEW}, author = {Jinrong Yang and Fa Wang and Shuqi Huang and Tao Feng and Kai Xiong and Yu Chen and Hui Chao}, doi = {10.1002/anie.202505689}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505689}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A Ruthenium(II) complex inhibits BRD4 for synergistic seno- and chemo-immunotherapy in cisplatin-resistant tumor cells}, volume = {64}, year = {2025}, }
• (2025). Hydrogenation of “Readily activated molecule” for glycine electrosynthesis. ANGEW, 64(23), e202505675. (www)

  @article{ , abstract = {The hydrogenation of glyoxylate oxime is the energy-intensive step in glycine electrosynthesis. To date, there has been a lack of rational guidance for catalyst design specific to this step, and the unique characteristics of the oxime molecule have often been overlooked. In this study, we initiate a theoretical framework to elucidate the fundamental mechanisms of glycine electrosynthesis across typical transition metals. By comprehensively analyzing the competitive reactions, proton-coupled electron transfer processes, and desorption steps, we identify the unique role of the glyoxylate oxime as a “readily activated molecule”. This inherent property positions Ag, featuring weak adsorption characteristics, as the “dream” catalyst for glycine electrosynthesis. Notably, a record-low onset potential of −0.09 V versus RHE and an impressive glycine production rate of 1327 µmol h −1 are achieved when using an ultralight Ag foam electrode. This process enables gram-scale glycine production within 20 h and can be widely adapted for synthesizing diverse amino acids. Our findings underscore the vital significance of considering the inherent characteristics of reaction intermediates in catalyst design.}, archive = {J_ANGEW}, author = {Xiaowen Sun and Egon Campos dos Santos and Mingtao Li and Yujie Shi and Kanglei Pang and Miao Zhang and Jiayin Yuan and Hong Liu and Xiaowen Yu}, doi = {10.1002/anie.202505675}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505675}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogenation of “Readily activated molecule” for glycine electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Interweaved nanofiber anode coating based on covalent organic frameworks for high-performance lithium-metal batteries. ANGEW, 64(23), e202505626. (www)

  @article{ , abstract = {High-rate lithium-metal batteries call for unique interfacial structures of anode with interfacial compatibility, facilitated lithium insertion/extraction and dendrite suppression properties to meet the growing high-rate demand. Here, we develop an interweaved porous coating based on a kind of covalent organic framework (ODH─Cu 3 ─COF) based helical nanofibers through the assembly of non-linear oxalyldihydrazide unit and rigid Cu 3 unit. The interweaved helical nanofibers network with well-arranged polar groups (i.e., C═N, ─CO─NH─, and pyrazole groups) could serve as nuclei sites to achieve fast Li + insertion/extraction and dendrite suppression in high-rate conditions. Benefiting from the advantages of interface design, the resultant ODH─Cu 3 ─COF modified anode improves the Coulombic efficiency (97.5%, 120 cycles at 5 mA cm −2 ) and showcases a stable lifespan (1000 h at 2 mA cm −2 and 2 mAh cm −2 ) in symmetric cell. Moreover, the high-rate property of ODH─Cu 3 ─COF@Li||LFP full cell presents an excellent cycling stability (900 cycles at 5 C) in commercial carbonate electrolyte. Theoretical calculations reveal that lithiophilic ODH─Cu 3 ─COF has high Li affinity to reduce the nucleation barrier and achieve fast desolvation process in an interface to promote the lifespan of high-rate lithium-metal batteries.}, archive = {J_ANGEW}, author = {Huifen Zhuang and Can Guo and Wenhai Feng and Liwen Wang and Zixi Zheng and Qi Li and Haifu Zhang and Yifa Chen and Ya-Qian Lan}, doi = {10.1002/anie.202505626}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interweaved nanofiber anode coating based on covalent organic frameworks for high-performance lithium-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Preparation of thermally and photochemically immobilized N-type conjugated polymer films via quantitative backbone editing. ANGEW, 64(23), e202505608. (www)

  @article{ , abstract = {We report a series of n-type conjugated polymers based on PNDI-TfBTT and PNDIV-TfBTT backbones constructed from electron-deficient naphthalene diimide (NDI) and fluorinated benzothiadiazole (fBT) units, with PNDIV-TfBTT incorporating a vinylene spacer. Quantitative postpolymerization modification (PPM) via nucleophilic substitution replaced the fBT fluorine with thioether side chains, optionally containing azide groups. Thioether substitution improved solubility, while subtly changing the ordering of polymer films. Azide incorporation enabled both thermal and photochemical crosslinking, yielding insoluble and immobile films that retained good electron transport; although UV crosslinking initially reduced mobility, subsequent thermal annealing largely restored crystallinity and performance. This work underscores the utility of precise backbone editing to fine-tune the electronic and morphological properties of n-type polymers, offering new avenues for the fabrication of stable, patterned active layers in advanced organic electronic devices.}, archive = {J_ANGEW}, author = {Charlotte Rapley and Adam V. Marsh and Edgar Gutierrez-Fernandez and Mohamad Insan Nugraha and Flurin Eisner and Martina Rimmele and Jaime Martín and Thomas D. Anthopoulos and Martin Heeney}, doi = {10.1002/anie.202505608}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Preparation of thermally and photochemically immobilized N-type conjugated polymer films via quantitative backbone editing}, volume = {64}, year = {2025}, }
• (2025). Bright and versatile azetidinecarboxamide-based Fluorophore–Ligand conjugates for high-resolution cell imaging. ANGEW, 64(23), e202505579. (www)

  @article{ , abstract = {Fluorophore–ligand conjugates play a pivotal role in cellular imaging, providing high target specificity. However, simultaneously achieving conjugates with high brightness and ligand-targeting diversity presents significant challenges. Traditional strategies often require complex, multistep modifications for fluorophore enhancement and ligand conjugation. Here, we present an azetidinecarboxamide strategy that addresses these challenges by integrating brightness enhancement and ligand conjugation capabilities within a single molecular framework. The azetidinecarboxamide core suppresses twisted intramolecular charge transfer (TICT), thereby enhancing fluorescence quantum yield. Its carbonyl group provides a versatile site for conjugating a wide range of targeting ligands, enabling the rapid development of diverse and tunable fluorophore–ligand conjugates. This streamlined approach reduces synthetic complexity, accelerates probe development, and is compatible with a wide variety of fluorophores, such as coumarin, naphthalimide, NBD, rhodol, rhodamine, and silicon–rhodamine, facilitating the creation of high-performance, multifunctional probes for advanced cellular imaging.}, archive = {J_ANGEW}, author = {Ning Xu and Qinglong Qiao and Chao Wang and Wei Zhou and Pengjun Bao and Jin Li and Shaowei Wu and Xiaogang Liu and Zhaochao Xu}, doi = {10.1002/anie.202505579}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bright and versatile azetidinecarboxamide-based Fluorophore–Ligand conjugates for high-resolution cell imaging}, volume = {64}, year = {2025}, }
• (2025). Biomimetic hierarchical construction of anti-tumor polyoxopalladates for cancer therapy. ANGEW, 64(23), e202505564. (www)

  @article{ , abstract = {Inspired by the construction scheme of biomacromolecules, a hierarchical assembly based on the lacunary polyoxopalladate (POP) of [SrPd 12 O 6 (OH) 3 (PhAsO 3 ) 6 (OAc) 3 ] 4− (SrPd 12 ) has been achieved. As a structurally programmable molecular building block, SrPd 12 is used to evolve from monomer via dimer to supramolecular aggregates in a controlled manner. In such process, the open-shell-type monomers are covalently integrated into bowl- or cage-like dimers via a direct or indirect splicing strategy. Upon that, hydrogen bond and hydrophobic effects are further hired to fabricate supramolecular aggregates of varied host–guest archetypes, thereby completing a hierarchical construction. In consideration of the combined advantages of noble metals and polyoxometalates in cancer treatment, both in vitro and in vivo anti-tumor assays of these SrPd 12 -derived POPs were studied in detail. A structure-dependent anti-tumor activitywas observed, originating from an imbalance of damage and repair of DNA as anti-tumor mechanism.}, archive = {J_ANGEW}, author = {Yue Zhao and Zheran Liu and Zijian Qin and Qinlong Wen and Jing Du and Xiang-Yu Ren and Chao-Qin Chen and Xingchen Peng and Ulrich Kortz and Peng Yang}, doi = {10.1002/anie.202505564}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505564}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biomimetic hierarchical construction of anti-tumor polyoxopalladates for cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Stimuli-responsive equilibrium in N-heterocyclic carbene-supported transition metal complexes: Selective isolation of multinuclear species. ANGEW, 64(23), e202505558. (www)

  @article{ , abstract = {The Ag I –N-heterocyclic carbene (NHC) complexes ( 3a , b ) derived from bis(NHC) ligand 1 , which exhibit a temperature- and concentration-dependent equilibrium between the trinuclear and tetranuclear forms, has been successfully isolated, which is slow on NMR time scale. Intriguingly, by freezing this slow equilibrium, facilitated by strong and stable H-bonding, we could achieve selective isolation of the tetranuclear species ( 3a , b - II ). On the other hand, encapsulation of an anionic guest, ClO 4 , led to exclusive formation of the guest encapsulated trinuclear Ag I -NHC complex, 3a - I . This is unprecedented and marks the first instance where selective isolation of both the species involved in an equilibrium using a C-donor ligand could be attained. In contrast, distinct behavior was observed with the Au I ion, possessing the same linear geometry, however, with stronger M–C NHC bonds. In this context, a stable non-exchangeable ≈1:1 mixture ( 4a , b ) of the tri- and tetranuclear Au I -NHC complexes were obtained via transmetalation of both equilibrating ( 3a , b ) and the H-bonded tetranuclear Ag I -NHC complexes ( 3a , b - II ). Moreover, by aptly adjusting the reaction parameters of transmetalation process, the trinuclear Au I -NHC complex ( 4a , b - I ) could indeed be obtained selectively. Overall, this study highlights a pioneering approach for the control of an equilibrium between different nuclearity metallo-supramolecular species engaging C-donor ligands.}, archive = {J_ANGEW}, author = {Shashi Kumar and Arnab Rit}, doi = {10.1002/anie.202505558}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505558}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stimuli-responsive equilibrium in N-heterocyclic carbene-supported transition metal complexes: Selective isolation of multinuclear species}, volume = {64}, year = {2025}, }
• (2025). Blocking the operando formation of single-atom spectators by interfacial engineering. ANGEW, 64(23), e202505507. (www)

  @article{ , abstract = {Aside from activity and selectivity, catalyst stability is a key focus in heterogeneous catalysis research. Although sintering of metal species has been considered the primary cause for deactivation of metal catalysts, our study reveals that the loss of activity at low reaction temperatures in the CeO 2 -supported Pt (Pt/CeO 2 ) catalyst in complete propane oxidation is due to the dispersion of Pt ensemble sites (nanoclusters) and their subsequent operando conversion into Pt single atoms under reaction conditions. These Pt single-atom species exhibit low reactivity and act as spectators in the low-temperature reaction region. To address this issue, we engineered the surface of CeO 2 by introducing NbO x , which does not directly interact with Pt. Instead, NbO x blocks the strong binding sites for Pt on CeO 2 , thereby preventing Pt redispersion/fragmentation and preserving reactive Pt ensembles. This strategy led to a remarkable 37-fold increase in the reaction rate compared to the Pt/CeO 2 catalyst. Our findings emphasize the importance of suppressing the formation of noble metal single-atom spectators through innovative surface engineering strategy. These mechanistic insights not only advance the understanding of the materials science of Pt/CeO 2 but also extend to critical technological fields such as energy conversion systems and environmental remediation technologies.}, archive = {J_ANGEW}, author = {Xuan Tang and Shasha Ge and Yao Lv and Geng Sun and Zhaohua Wang and Junzhong Xie and Mi Peng and Yao Xu and Jie Zhang and Bingqing Yao and Qian He and Yanglong Guo and Wangcheng Zhan and Li Wang and Lihui Zhou and Bingjun Xu and Sheng Dai and Yun Guo and Ding Ma}, doi = {10.1002/anie.202505507}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505507}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Blocking the operando formation of single-atom spectators by interfacial engineering}, volume = {64}, year = {2025}, }
• (2025). Expanding the spectral range in t2-supertetrahedral nonlinear optical chalcogenides via incorporating inorganic polycations. ANGEW, 64(23), e202505421. (www)

  @article{ , abstract = {Metal-chalcogenide supertetrahedral clusters that exhibit significant hyperpolarizability are highly sought after as promising nonlinear optical (NLO) function modules. However, these “naked” anionic clusters are commonly coordinated with organic ligands to maintain electrical neutrality, which unfortunately limits their utility in the mid- and far-infrared (MFIR) region due to strong absorption. In this study, we successfully substituted the organic ligand with the unprecedented (X 4 K 8 Ba 2 ) 8+ supertetrahedral cations, which are suitable size and high charge, and integrated them with (In 4 Se 10 ) 8− supertetrahedral clusters to form 3D salt-inclusion chalcogenides (SICs), [K 4 BaX 2 ][In 6 Se 11 ] (X = Cl 1 , Br 2 ). As anticipated, the parallel arrangement of the (In 4 Se 10 ) 8− clusters yielded splendid second-harmonic generation intensities (2.2–2.4 × benchmark AgGaS 2 @1910 nm for 1 and 2 , respectively), ranking among the top within the SICs category. Most importantly, the introduction of inorganic polycations with a broad cut-off IR edge is a key factor in enabling 1 to achieve an ultrawide transparency range (0.7 to 18.1 µm) that covers the crucial atmospheric windows (3–5 and 8–14 µm). Indeed, replacing the organic ligand with an inorganic polycation allows supertetrahedra-based chalcogenides to fulfill the broad-spectrum criteria of NLO materials.}, archive = {J_ANGEW}, author = {Shao-Min Pei and Xiao-Ming Jiang and Bin-Wen Liu and Guo-Cong Guo}, doi = {10.1002/anie.202505421}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505421}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expanding the spectral range in t2-supertetrahedral nonlinear optical chalcogenides via incorporating inorganic polycations}, volume = {64}, year = {2025}, }
• (2025). A high-efficiency ultraviolet organic light-emitting diode employing a double Boron–Oxygen–Nitrogen-based emitter. ANGEW, 64(23), e202505328. (www)

  @article{ , abstract = {Designing high-efficiency ultraviolet organic light-emitting diodes (UV OLEDs) remains challenging due to the need for efficient utilization of triplet excitons while maintaining a wide bandgap. In this study, we designed double boron–oxygen–nitrogen-based polycyclic aromatic hydrocarbons (dBON-PAHs) with rigid planar structures and developed a novel UV emitter, BO-N, featuring hybridized local and charge-transfer (HLCT) properties. BO-N exhibited UV emission in toluene solution and 1,3-di(9 H -carbazol-9-yl)benzene (mCP) film, with photoluminescence (PL) peaks of 391 and 400 nm and narrow full width at half-maximum (FWHM) values of 15 and 34 nm, respectively. The device doped with 5 wt% BO-N achieved a narrowband UV emission with an FWHM of 37 nm, an electroluminescence peak ( λ EL ) of 399 nm, and CIE coordinates of (0.166, 0.030). Moreover, the device attained a record-high maximum external quantum efficiency (EQE max ) of 18.6% among reported HLCT-based UV OLEDs with CIE y < 0.05. These findings highlight the great potential of double BON-PAHs as robust emitters for high-performance UV OLEDs.}, archive = {J_ANGEW}, author = {Feng Zhan and Kewei Xu and Taiju Tsuboi and Yuanbin She and Guijie Li}, doi = {10.1002/anie.202505328}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505328}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A high-efficiency ultraviolet organic light-emitting diode employing a double Boron–Oxygen–Nitrogen-based emitter}, volume = {64}, year = {2025}, }
• (2025). Antifreeze protein mimics realizing stable low-temperature-resistant aqueous zn-ion batteries with high water content. ANGEW, 64(23), e202505325. (www)

  @article{ , abstract = {Rechargeable aqueous metal batteries offer inherent safety and low cost due to the predominance of water in their aqueous electrolytes, yet their practical applications are severely limited by electrolyte freezing under subzero conditions. Drawing inspiration from the mechanism of antifreeze proteins (AFPs) that protect living organisms from freezing damage, we synthesize oxidized quasi-carbon nitride quantum dots (OQCNs) featuring a regularly in-plane structure commensurate with the prism face of hexagonal ice crystal. At an ultralow concentration, the as-synthetic OQCNs effectively mimic AFP functionalities by controlling ice crystal morphology, suppressing ice growth kinetics, and inhibiting ice recrystallization. This synergistic mechanism preserves continuous ion transport pathways while mitigating physical damage to battery components caused by ice crystal growth. Molecular dynamics simulations demonstrate that the Gibbs–Thomson effect underpins the suppression of ice growth, avoiding complete solidification of the electrolyte under subzero conditions. The OQCNs-modified electrolyte exhibits exceptional cryogenic performance at −30 °C, with Zn||Zn symmetric cell maintaining stable cycling of 1000 h and Zn||NH 4 + -intercalated vanadium oxide (NVO) battery preserving 91.48% capacity retention through 5000 cycles (over 90 days). This work unveils a bioinspired paradigm that significantly enhances the performance of eco-friendly, high-moisture electrolytes, paving the way for robust, low-temperature-resistant zinc-ion batteries and related aqueous electrolyte-based technologies.}, archive = {J_ANGEW}, author = {Zeyu Zhu and Haoran Ma and Hongzhong Du and Leining Zhang and Jiahui Wu and Chong Gao and Wei Li and Xiaofei Chen and Yaqiong Su and Dan Wang and Xiaoting Chen and Zhiyuan He}, doi = {10.1002/anie.202505325}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505325}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antifreeze protein mimics realizing stable low-temperature-resistant aqueous zn-ion batteries with high water content}, volume = {64}, year = {2025}, }
• (2025). Reaction of nitrate radicals and DMPO in non-aqueous media: A novel detection tool to highlight the nitrate radical role in photocatalytic processes. ANGEW, 64(23), e202505313. (www)

  @article{ , abstract = {The reaction of DMPO as the spin trapping agent with nitrate radicals photocatalytically generated results in the formation of DMPOX showing a highly specific EPR spectrum. The method can be used as a semi-quantitative and convenient way to detect nitrate radicals in non-aqueous solutions/suspensions, which was never achieved up to now through EPR spectroscopy. Results support in a more direct way the proposed generation and reactivity of nitrate radicals in photocatalytic media and open a new chapter in the field of heterogeneous photocatalysis.}, archive = {J_ANGEW}, author = {Alessia Zollo and Alessandro Gottuso and Leonardo Palmisano and Elio Giamello and Francesco Parrino and Stefano Livraghi}, doi = {10.1002/anie.202505313}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505313}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reaction of nitrate radicals and DMPO in non-aqueous media: A novel detection tool to highlight the nitrate radical role in photocatalytic processes}, volume = {64}, year = {2025}, }
• (2025). Modulating the chromophores of metal-covalent organic frameworks for boosting low-concentration CO2 photoreduction. ANGEW, 64(23), e202505292. (www)

  @article{ , abstract = {The development of efficient photocatalysts to convert low-concentration CO 2 into the value-added chemicals and fuels is particularly interesting yet remains highly challenging. Herein, we designed and synthesized three metal-covalent organic frameworks (MCOFs) through the Schiff-base condensation reactions between trinuclear copper complex and different BDP-based chromophores (BDP = 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) for visible-light-driven reduction of low-concentration CO 2 (15%) to HCOO − . As a result, MCOF-ANT containing anthracene (ANT) groups achieves the highest HCOO − production rate of 1658 µmol g −1 h −1 (HCOO − selectivity, ∼100%) in the absence of any additional noble-metal photosensitizers under a laboratory light source, which is 7.2 and 2.1 times higher than those of MCOF-Ph and MCOF-Nap with phenyl (Ph) and naphthalene (Nap) groups, respectively. Furthermore, MCOF-ANT also exhibits excellent photocatalytic activity for the reduction of low-concentration CO 2 (15%) to HCOO − under natural sunlight, with a HCOO − production rate of 1239 µmol g −1 h −1 (HCOO − selectivity, ∼100%). Experiments and theoretical calculations reveal that the presence of ANT in MCOF-ANT is favorable to the visible-light harvesting and charge separation, as well as the formation of *OCO intermediate, which clearly accounts for its superior catalytic activity.}, archive = {J_ANGEW}, author = {Chong-Jiu Lu and Ji-Hong Zhang and Jian-Hua Mei and Yun-Nan Gong and Tong-Bu Lu and Di-Chang Zhong}, doi = {10.1002/anie.202505292}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505292}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating the chromophores of metal-covalent organic frameworks for boosting low-concentration CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Isolated and paired metal sites in zeolites using solid-state ion exchange. ANGEW, 64(23), e202505186. (www)

  @article{ , abstract = {Isolated and paired extraframework transition metal cations in zeolites are emerging as top candidates for numerous applications, including, but not limited to, selective methane oxidation to methanol, selective catalytic reduction of nitrogen oxides, propane dehydrogenation, propylene epoxidation, and direct air capture of carbon dioxide. Importantly, these well-defined heterogeneous catalysts offer parallels with molecular and metalloenzyme catalytic active sites. Aqueous-phase ion exchange (APIE) is the most common synthesis technique to obtain these catalysts. Solid-state ion exchange (SSIE) is an often overlooked technique that offers synthetic advantages compared to APIE. Thus, recent advances in solid-state synthesis strategies merit contemporary contextualization. In this minireview, we describe the basic principles, methods, mechanisms, challenges, and advances in solid-state ion exchange in the context of well-defined transition metal cation active sites located in extraframework positions of the zeolite.}, archive = {J_ANGEW}, author = {Rio G. Moore and James M. Crawford}, doi = {10.1002/anie.202505186}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isolated and paired metal sites in zeolites using solid-state ion exchange}, volume = {64}, year = {2025}, }
• (2025). Isolable three-coordinate base-stabilized alumylene: A precursor of persistent acceptor-free monomeric aluminum oxide. ANGEW, 64(23), e202505181. (www)

  @article{ , abstract = {An isolable monomeric alumylene 2 stabilized by two donating ligands (phosphine and NHC) has been synthesized. Experimental and theoretical analysis confirm that the NHC ligand in 2 is labile and reversibly dissociates from the Al I center above −20 °C. Of particular interest, despite being thermodynamically stabilized by two donor ligands, alumylene complex 2 exhibits a high reactivity with a considerably higher nucleophilicity compared to the monophosphine-ligated complex 5 . It is interesting to note that 2 reacts immediately with N 2 O at −90 °C, allowing the synthesis of bis-ligated aluminum oxide 15 , which is stable up to −70 °C.}, archive = {J_ANGEW}, author = {José Miguel León Baeza and Huihui Xu and Shintaro Takahashi and Antoine Baceiredo and Rene Segundo Rojas Guerrero and Daisuke Hashizume and Nathalie Saffon-Merceron and Vicenç Branchadell and Tsuyoshi Kato}, doi = {10.1002/anie.202505181}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505181}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isolable three-coordinate base-stabilized alumylene: A precursor of persistent acceptor-free monomeric aluminum oxide}, volume = {64}, year = {2025}, }
• (2025). Controlled catalysis delivering high molecular weight polyesters as recyclable alternatives to polystyrenes. ANGEW, 64(23), e202505070. (www)

  @article{ , abstract = {An organometallic Al(III)K(I) catalyst shows exceptional control in the epoxide/anhydride ring opening copolymerization (ROCOP), producing high molecular weight polyesters ( M n ∼ 100 kg·mol −1 ). The catalysis is highly effective using cyclohexene oxide, cyclopentane oxide, substituted cyclohexene oxide, and butylene oxide, each combined with phthalic anhydride. The polyesters show entanglement molecular weights, determined by oscillatory shear rheology, from 13 to 50 kg·mol −1 with cyclopentene and substituted cyclohexene moieties being particularly effective (highly entangled). The lead polyesters show high glass transition temperatures (94 °C < T g < 137 °C), high tensile strengths (40 MPa < σ < 47 MPa) and tensile modulii (0.6 GPa < E y < 0.9 GPa); their properties are similar to polystyrene. The polyesters are all recyclable by repeated cycles of compression molding, and show equivalently high thermal-mechanical performances even over repeated recycles.}, archive = {J_ANGEW}, author = {Nora Jannsen and Kam C. Poon and Alexander Craze and Chang Gao and Charlotte K. Williams}, doi = {10.1002/anie.202505070}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled catalysis delivering high molecular weight polyesters as recyclable alternatives to polystyrenes}, volume = {64}, year = {2025}, }
• (2025). Electric field-induced fast li-ion channels in ionic plastic crystal electrolytes for all-solid-state batteries. ANGEW, 64(23), e202505035. (www)

  @article{ , abstract = {The practical use of all-solid-state batteries (ASSBs) is hindered by the intractable electrolyte/electrode interfacial resistance and discontinuous ion transport networks within electrodes. Ionic plastic crystals offer a potential solution to these challenges due to their melt-permeable properties to the electrodes. However, their limited ionic conductivity restricts their application. Here, we propose a design principle for solid-state electrolytes based on an electric field-induced strategy by using ionic plastic crystals with low self-migrating and high conductivity toward target ions. Through the external potential difference, an ordered internal electric field is generated within the ionic plastic crystal-based solid-state electrolytes (IPCEs), which mitigates the coordination limitations of anions on target ions to facilitate rapid ion conduction. The prepared IPCE demonstrates high ionic conductivity (1.08 × 10 −3 S cm −1 at 25 °C) and a Li + transfer number (0.77), enabling the application of ASSBs over a wide temperature range (from 0 to 60 °C). Furthermore, the assembled Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 ASSBs exhibit stable cycling, maintaining 97.5% capacity retention after 500 cycles at 25 °C. This work provides a fresh perspective on the practical application of ASSBs, highlighting the potential of IPCEs in enhancing battery performance.}, archive = {J_ANGEW}, author = {Xinyu Ma and Jiangtao Yu and Xiuyang Zou and Xiaoliang Wang and Huihui Wang and Yin Hu and Minzhi Duan and Songlin Tao and Shipeng Sun and Yanbin Shen and Feng Yan}, doi = {10.1002/anie.202505035}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202505035}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electric field-induced fast li-ion channels in ionic plastic crystal electrolytes for all-solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). A nucleus-targeting Ruthenium(II) complex induces DNA condensation in cisplatin-resistant tumor cells. ANGEW, 64(23), e202504970. (www)

  @article{ , abstract = {One of the conventional ways to eradicate tumor cells is to utilize chemotherapy agents, e.g., cisplatin, to induce DNA damage. However, DNA damage repair mechanisms can significantly limit the therapeutic efficacy of cisplatin. These mechanisms enable tumor cells to repair the DNA damage caused by the drug, leading to resistance. Cisplatin and similar drugs bind to specific DNA sites without significantly altering their conformation. As a result, DNA repair enzymes can still attach to and repair the damaged DNA. To address this issue, we designed four Ru(II) complexes ( RuC3 , RuC6 , RuC9 , and RuC12 ) with high positive charges of +8 valence and regulated their nuclear accumulation levels by adjusting the length of alkyl chains. RuC9 exhibits the highest nucleus accumulation level. DNA conformation was significantly altered by inducing DNA condensation through indiscriminately neutralizing the negative charge of the DNA backbone. This significant change prevents DNA-related enzymes from binding to DNA, ultimately leading to the efficient eradication of various tumor cell lines. To the best of our knowledge, it is the first work that kills tumor cells and overcomes cisplatin resistance through inducing DNA condensation.}, archive = {J_ANGEW}, author = {Ying Zhou and Kai Xiong and Tao Feng and Xianbo Wu and Jinzhe Liang and Yu Chen and Hui Chao}, doi = {10.1002/anie.202504970}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504970}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A nucleus-targeting Ruthenium(II) complex induces DNA condensation in cisplatin-resistant tumor cells}, volume = {64}, year = {2025}, }
• (2025). Pressure-induced emission luminogens enable optical logic gates toward lighting, scintillators, and anti-counterfeiting. ANGEW, 64(23), e202504913. (www)

  @article{ , abstract = {The pressure-induced emission luminogens (PIEgens) opened the door to highly emissive materials. However, the high-pressure phase with excellent optoelectrical properties is difficult to stabilize at ambient conditions, seriously limiting the practical applications. Here, we first lighted up non-emissive zero-dimensional (0D) metal halide (C 25 H 22 P) 2 SnCl 6 via pressure engineering, ultimately yielding the bright emission. Note that the quenched (C 25 H 22 P) 2 SnCl 6 after pressure treatment of 20.0 GPa exhibited very bright blue–white emission. This irreversible photoluminescence (PL) transition was associated with irreversible amorphization by increasing the potential barrier of phase transition through the steric hindrance effect. The increased distortion of inorganic octahedra and the enhanced hydrogen bond interaction within the amorphous (C 25 H 22 P) 2 SnCl 6 after pressure treatment were responsible for the bright emission. Thus, pressure-triggered PL turn-on behavior can serve as a robust optical switchable logic gate from the initially dark state “0” to the bright state “1”. Furthermore, the pressure-treated (C 25 H 22 P) 2 SnCl 6 exhibited an unexpected excitation-dependent emission. The unique characteristic of “PIE” with different colors can be decoded the Morse code encrypted with the pressure-treated (C 25 H 22 P) 2 SnCl 6 and different excitations. The quenched (C 25 H 22 P) 2 SnCl 6 -based phosphor-converted light-emitting diodes (pc-LEDs), X-ray dose rate detection and centimeter-level patterns highlighted great potentials in lighting, display, scintillators, and anti-counterfeiting.}, archive = {J_ANGEW}, author = {Wenya Zhao and Guanjun Xiao and Shi Qiu and Yuchen Shang and Yue Qin and Jiayi Yang and Jingtian Wang and Jiajia Ning and Yanjun Fang and Qingfeng Dong and Zhaodong Liu and Shunxin Li and Junfeng Gao and Bo Zou}, doi = {10.1002/anie.202504913}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pressure-induced emission luminogens enable optical logic gates toward lighting, scintillators, and anti-counterfeiting}, volume = {64}, year = {2025}, }
• (2025). Molecularly designed cathode for copper-benzimidazole-induced CO2 reduction to MeOH. ANGEW, 64(23), e202504783. (www)

  @article{ , abstract = {Conversion of carbon dioxide (CO₂) into value-added products is aimed to develop scalable technologies to promote a circular economy. While the electrochemical reduction of CO₂ to carbon monoxide (CO) and formic acid has advanced significantly, a major challenge remains achieving further reduced and more energy-dense products, such as methanol (MeOH), through sustainable pathways. Herein, we report a molecular electrode capable of direct six-electron reduction of CO₂ to MeOH using water as a proton source with a global Faradaic efficiency (FE G ) of 22% and product selectivity of 61% for MeOH. The design consists of an active copper-hydride center surrounded by two closely spaced benzimidazole–hydride units, facilitating the catalytic transfer of three hydrides to produce MeOH. The concurrent formation of formic acid and the absence of formaldehyde suggest that MeOH is generated via a formato pathway. DFT investigations revealed the complete mechanistic pathway, which supports the experimental observations. The morphology and stability of the electrode were evaluated before and after prolonged electrolysis (12 h) experiments using electron microscopic techniques.}, archive = {J_ANGEW}, author = {Pamela Bengtsson and Victor Liebgott and Lars Eriksson and Kjell Jansson and Cheuk-Wai Tai and Amrendra K. Singh and Belén Martín-Matute and Biswanath Das}, doi = {10.1002/anie.202504783}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504783}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecularly designed cathode for copper-benzimidazole-induced CO2 reduction to MeOH}, volume = {64}, year = {2025}, }
• (2025). Sustainable synthesis of concentrated formate via CO2 electrolysis integrated with cl2 formation. ANGEW, 64(23), e202504782. (www)

  @article{ , abstract = {Integrating CO 2 electrolysis with an industrially relevant anodic reaction enhances the economic feasibility and reduces carbon emissions in practical operations. In this study, we present an electrosynthesis strategy that integrates the CO 2 reduction reaction to produce concentrated formate solution with the Cl 2 formation in cation exchange membrane-based electrolyzers, scaling from 1 to 100 cm 2 electrode areas. Our process, equipped with two automated pH regulation strategies, achieved selectivities over 80% for formate and 95% for chlorine in a 25 cm 2 electrolyzer. Additionally, it demonstrated the ability to achieve formate concentrations up to 5.4 M during extended operation periods, establishing a new benchmark for electrochemical formate/formic acid synthesis. Techno-economic assessment and life cycle assessment further validated the process' sustainability, demonstrating a realistic path to profitability for valuable chemical production from CO 2 even without considering potential subsidies and carbon taxes.}, archive = {J_ANGEW}, author = {Haocheng Xiong and Donghuan Wu and Runyu Jiang and Haonan Li and Qikun Hu and Xi Lu and Bingjun Xu and Qi Lu}, doi = {10.1002/anie.202504782}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504782}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sustainable synthesis of concentrated formate via CO2 electrolysis integrated with cl2 formation}, volume = {64}, year = {2025}, }
• (2025). Frustrated lewis pair (FLP)-like (Cyclo)Addition of small organic molecules to a stable azomethine ylide. ANGEW, 64(23), e202504737. (www)

  @article{ , abstract = {Azomethine ylides are 1,3-dipolar zwitterions typically used for constructing N-heterocycles by 3+2-cycloaddition reactions. We report here a pyridyl-tethered isolable azomethine ylide ( AY ) that activates a series of H−E bonds (E═B, Si, Al, O) in FLP-like fashion. The reactions are probed mechanistically by DFT calculations and each case appears to be distinct from others. While the HBpin activation is stepwise, the same of PhSiH 3 is concerted. The AlH 3 activation is also stepwise but takes place across the 1,5-(C + /N − ) dipole. The hydrolysis of AY fits better with a “relay” mechanism with two H 2 O molecules working in tandem. The B−B bond of B 2 pin 2 is also cleaved but in an intriguingly different way, by delivering both the Bpin moieties at the carbenic site. Though the challenging H 2 activation fails, a transfer hydrogenation of AY by NH 3 •BH 3 is readily achieved. AY also undergoes cycloadditions with various dipolarophiles including unactivated alkene and alkynes. In this regard, AY makes an interesting distinction between CO 2 and CS 2 by staying inert to the former but easily cycloadding the latter. DFT analysis justifies this dichotomy by showing the cycloaddition of CO 2 as thermodynamically disfavored.}, archive = {J_ANGEW}, author = {Sudip Baguli and Subham Sarkar and Dibyendu Mallick and Debabrata Mukherjee}, doi = {10.1002/anie.202504737}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504737}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frustrated lewis pair (FLP)-like (Cyclo)Addition of small organic molecules to a stable azomethine ylide}, volume = {64}, year = {2025}, }
• (2025). Probing inside the catalyst layer on gas diffusion electrodes in electrochemical reduction of CO and CO2. ANGEW, 64(23), e202504715. (www)

  @article{ , abstract = {Gas diffusion electrodes (GDEs) are widely used in electrochemical CO and CO 2 reduction reactions (CO (2) RR) in flow cells due to their ability to alleviate mass transport limitations of gaseous reactants. The flow cell configuration makes uniform distribution of reactants, intermediates, products, and speciation within the catalyst layer (CL) unlikely. In this work, a first-of-its-kind in situ characterization technique capable of probing the cross section of the CL with confocal Raman spectroscopy was developed to investigate the speciation distribution across the Cu CL in CO (2) RR with a spatial resolution of ∼4 µm. In both CORR in alkaline medium and CO 2 RR in acidic electrolyte, the active region of CL was identified as that with the presence of the Raman band for adsorbed CO (CO ad ). The strong correlation of CO ad and CO 3 2− bands provides the first spectroscopic evidence that CO 2 RR only occurs in an alkaline microenvironment.}, archive = {J_ANGEW}, author = {Qiwen Sun and Jin Wang and Linke Fu and Yao Ye and Xiaoxia Chang and Bingjun Xu}, doi = {10.1002/anie.202504715}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504715}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing inside the catalyst layer on gas diffusion electrodes in electrochemical reduction of CO and CO2}, volume = {64}, year = {2025}, }
• (2025). H2S sensing with SnO2-based gas sensors: Sulfur poisoning mechanism revealed by operando DRIFTS and DFT calculations. ANGEW, 64(23), e202504696. (www)

  @article{ , abstract = {Real-time detection of toxic and flammable H 2 S remains challenging for cost-effective semiconducting metal oxide (SMOX) sensors due to the insufficient focus on and inherently poor understanding of the sulfur-poisoning effect. This research, focusing on SnO 2 as a model for SMOX sensors, identifies the formation of sticky sulfite and sulfate surface species as the root cause of poisoning through the detailed analyses of results obtained from operando diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) experiments and density functional theory (DFT) calculations. The formation of the poisoning species is highly energetically favorable. Meanwhile, the decomposition of sulfite and sulfate appears unfavorable at the typical operating temperature of 300 °C and is only feasible around the literature-reported 500 °C. The sulfur poisoning effect is also likely to occur with SO 2 and other sulfur-containing volatile organic compounds (VOCs). Overcoming this issue is expected to require surface additives and/or alternative SMOX materials capable of providing different reaction pathways. The significance of metal-sulfur-oxygen chemistry extends beyond SMOX gas sensors to desulfurization catalysts, denitration catalysts, and solid oxide fuel cells.}, archive = {J_ANGEW}, author = {Tingqiang Yang and Matthias Boepple and Anne Hémeryck and Antoine Jay and Sara Karwounopoulos and Udo Weimar and Nicolae Barsan}, doi = {10.1002/anie.202504696}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504696}, shortjournal = {Angew. Chem. Int. Edit.}, title = {H2S sensing with SnO2-based gas sensors: Sulfur poisoning mechanism revealed by operando DRIFTS and DFT calculations}, volume = {64}, year = {2025}, }
• (2025). Potassium Tetraiodatoiodate(III) Iodate(V): A nonlinear optical crystal with exceptional second-harmonic generation and full-wavelength phase matching. ANGEW, 64(23), e202504673. (www)

  @article{ , abstract = {The development of nonlinear optical materials with large nonlinear optical susceptibilities, wide transmission ranges, and comprehensive full-wavelength phase matching capabilities remains a significant challenge. In this study, we synthesized a novel potassium tetraiodatoiodate(III) iodate(V) via an in-situ reduction and complexation reaction. The resulting compound, K 2 [I III (I V O 3 ) 4 ]I V O 3 , exhibits exceptional second-harmonic generation responses (21.6KH 2 PO 4 at 1064 nm, 1.0KTiOPO 4 at 2050 nm), a wide transparency range from the visible to the mid-infrared wavelengths (0.37–6.05 and 7.03–13.40 µm), and a high birefringence (0.358 at 543 nm) to achieve full-wavelength phase matching. These properties are primarily ascribed to the synergistic substantial hyperpolarizability and polarizability anisotropy exhibited by the [I III (I V O 3 ) 4 ] − complex ions, which comprise square-planar coordinated trivalent iodine and optimally arranged iodate ligands. This study demonstrates the pivotal role of nonmetallic cation centered coordination entities in influencing linear and nonlinear optical properties, a discovery that has significant implications for the development of innovative inorganic functional materials.}, archive = {J_ANGEW}, author = {Min-Quan Lin and Chun-Li Hu and Meng-Fan Duan and Bing-Xuan Li and Jiang-Gao Mao and Bing-Ping Yang}, doi = {10.1002/anie.202504673}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504673}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Potassium Tetraiodatoiodate(III) Iodate(V): A nonlinear optical crystal with exceptional second-harmonic generation and full-wavelength phase matching}, volume = {64}, year = {2025}, }
• (2025). Environmental history is transferred via minerals altering formose reaction pathways. ANGEW, 64(23), e202504659. (www)

  @article{ , abstract = {It is generally accepted that minerals were an important source of prebiotic catalysis. In this work we demonstrate how the prebiotic sugar forming formose reaction is guided to unique reaction compositions in the presence of a variety of minerals. When the same mineral is transferred between multiple sequential batch reactions, a new reaction composition is obtained after each reaction cycle. We attribute this effect to the adsorption of catalytic Ca(OH) 2 to mineral surfaces. Further exploration shows that first exposing the mineral surface to the aqueous catalyst allows the mineral to subsequently produce formose outputs without the need for any additional catalyst to be present. As such, the mineral surface functions as storage of the preceding environmental conditions. Our work supports the development of chemical complexity through the transfer of information between sequences of chemical environments.}, archive = {J_ANGEW}, author = {Thijs J. de Jong and Astra D. Demertzi and William E. Robinson and Wilhelm T. S. Huck}, doi = {10.1002/anie.202504659}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504659}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Environmental history is transferred via minerals altering formose reaction pathways}, volume = {64}, year = {2025}, }
• (2025). Organic–Inorganic hybrid rare earth halide glasses for tunable multicolor X-ray scintillation. ANGEW, 64(23), e202504658. (www)

  @article{ , abstract = {Rare earth–based all-inorganic glass-ceramics have played an important role in the field of optoelectronics. However, the research of organo–inorganic hybrid rare earth halide glass that can be produced at low temperatures is still in the blank stage. In this paper, we report for the first time novel amorphous organic–inorganic hybrid rare earth–based halide luminescent glasses, Bzmim 3 LnCl 6 (Bzmim = 1-benzyl-3-methylimidazolium; Ln 3+ = Tb 3+ , Eu 3+ ), and realize tunable multicolor photoluminescence emission. By adjusting the ratio of Tb 3+ /Eu 3+ within the Bzmim 3 LnCl 6 glass, we have successfully induced controllable radioluminescence properties ranging from green to red under X-ray irradiation. Notably, these amorphous organic–inorganic hybrid rare earth glasses exhibit remarkable sensitivity to variations in X-ray dose, suggesting promising applications in the field of passive color visualization radiation detection. Furthermore, the Bzmim 3 TbCl 6 glass demonstrates exceptional light transmittance greater than 85% across the 480–800 nm range, which results in superior spatial resolution in X-ray imaging (>25 lp mm −1 ). These findings not only provide a good example for the design and development of hybrid rare earth–based halide glasses but also hold great potential for applications in detection, sensing, illumination, and display technologies.}, archive = {J_ANGEW}, author = {Tian-Chi Wang and Zi-Lin He and Jian-Bin Luo and Qing-Peng Peng and Jun-Hua Wei and Kong-Lan Chen and Jing-Hua Chen and Xiu-Xian Guo and Dai-Bin Kuang}, doi = {10.1002/anie.202504658}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic–Inorganic hybrid rare earth halide glasses for tunable multicolor X-ray scintillation}, volume = {64}, year = {2025}, }
• (2025). Peripheral engineering of multiple-resonance framework targeting efficient organic lasers. ANGEW, 64(23), e202504652. (www)

  @article{ , abstract = {Multiple-resonance thermally activated delayed fluorescent (MR-TADF) emitters have emerged as promising candidates for organic laser applications due to the potential for simultaneously achieving large oscillator strength and triplet utilization. In this study, we investigate the impact of peripheral tert -butyl (t-Bu)- and phenyl (Ph)-substituents on the typical 9-(phenylcarbazol-3-yl)-9H-carbazole-3-carbonitrile (CzBN) MR framework. Although these modifications preserve the frontier molecular orbital distribution with large oscillator strengths, they significantly influence excited-state dynamics and molecular aggregation even at low doping concentrations. Introducing Ph substituents extends the π–conjugation extension of CzBN, promoting closer molecular packing, detrimental molecular aggregation, and significantly broadening the excited-state absorption (ESA) band, which negatively impacts lasing performance. In contrast, CzBN-tBu, incorporating t -Bu groups as nonconjugated substituents, demonstrated reduced molecular aggregation and a distinct separation between the ESA band and stimulated emission region. Consequently, the optimal distributed feedback lasing performance is achieved by CzBN-tBu across various doping concentrations, resulting in the lowest lasing threshold of 3.4 µJ cm −2 . These findings underscore the impact of inherent aggregation at low doping ratios on lasing activities, highlighting the crucial role of rational peripheral engineering in modulating molecular interactions and excited-state dynamics, offering design strategies for developing MR lasing molecules.}, archive = {J_ANGEW}, author = {Tuul Tsagaantsooj and Xun Tang and Tao Zhang and Yi-Ting Lee and Rajat Walia and Xian-Kai Chen and Chihaya Adachi}, doi = {10.1002/anie.202504652}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504652}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Peripheral engineering of multiple-resonance framework targeting efficient organic lasers}, volume = {64}, year = {2025}, }
• (2025). Temperature and solvent dual switch photochromic chiral ionic hydrogen-bonded organic framework for circularly polarized luminescence and advanced encryption. ANGEW, 64(23), e202504645. (www)

  @article{ , abstract = {Multi-response encryption materials with temperature control and time resolution have attracted widespread attention due to their unique response characteristics and higher application security. The design and development of photochromic crystalline materials with multiple stimulus responses remain challenging. In this study, we report a pair of responsive photochromic chiral ionic hydrogen-bonded organic framework (iHOF) R/S-iHOF-19, controlled by both temperature and solvent through charge-assisted synthesis. The chromophore tetrakis(4-sulfophenyl)ethylene (H4TPE) acts as an electron donor and (1R/S,2R/S)-1,2-diphenylethylenediamine (R/S-DPEN) as an electron acceptor and chiral source. Water and methanol molecules connect the donor and acceptor and interact to build a 3D supramolecular framework. Notably, water and methanol molecules form independent hydrogen-bonding channels within the iHOF structural framework, providing a transfer path for the photoinduced electrons. Surprisingly, the formation of a continuous chiral supramolecular framework by R/S-DPEN while generating photo-induced radicals under ultraviolet (UV) irradiation at −20 °C imparts excellent circularly polarized luminescence (CPL) properties to R/S-iHOF-19. The glum values reach −1.8 × 10 −3 and +3.75 × 10 −3 , respectively, and show an enhancement of the circular polarization of light with decreasing temperature. This CPL with unique low-temperature stimulus-responsive photochromism provides new guidance and perspectives for the development of information security and multiple encryption materials.}, archive = {J_ANGEW}, author = {Bin Zhou and Li-Hui Cao and Ming-Feng Huang and Yi Yang and Simeng Qi and Xiao-Jie Cao and Xu-Yong Chen}, doi = {10.1002/anie.202504645}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Temperature and solvent dual switch photochromic chiral ionic hydrogen-bonded organic framework for circularly polarized luminescence and advanced encryption}, volume = {64}, year = {2025}, }
• (2025). Enhanced p–d orbital coupling in unconventional phase RhSb alloy nanoflowers for efficient ammonia electrosynthesis in neutral media. ANGEW, 64(23), e202504641. (www)

  @article{ , abstract = {Phase control provides a promising approach for physicochemical property modulation of metal/alloy nanomaterials toward various electrocatalytic applications. However, the controlled synthesis of alloy nanomaterials with unconventional phases remains challenging, especially for those containing both p - and d -block metals. Here, we report the one-pot synthesis of ultrathin RhSb alloy nanoflowers (NFs) with an unconventional 2H phase. Using 2H RhSb NFs as an electrocatalyst for nitrite reduction reaction in neutral media, the optimal NH 3 Faradaic efficiency and yield rate can reach up to 96.8% and 47.2 mg h −1 mg cat −1 at −0.3 and −0.6 V (vs. reversible hydrogen electrode), respectively. With 2H RhSb NFs as a bifunctional cathode catalyst, the as-assembled zinc-nitrite/methanol batteries deliver a high energy efficiency of 96.4% and improved rechargeability with 120-h stable running. Ex/in situ characterizations and theoretical calculations have demonstrated that the phase change of RhSb from face-centered cubic ( fcc ) to 2H has optimized the electronic structure through stronger interactions between Rh and Sb by p – d orbital couplings, which improves the adsorption of key intermediates and reduces the reaction barriers of nitrite reduction to guarantee the efficient electrocatalysis. This work offers a feasible strategy of boosting the electrocatalytic performance of alloy nanostructures by integrating phase control and p – d orbital coupling.}, archive = {J_ANGEW}, author = {Fu Liu and Jingwen Zhou and Mingzi Sun and Zhihang Xu and Helin Wang and Ning Yao and Yunhao Wang and Fengkun Hao and Yuecheng Xiong and Juan Wang and Liang Guo and Qingbo Wa and Guozhi Wang and Xiang Meng and Mingzheng Shao and Chaohui Wang and Hsiao-Chien Chen and Hao Ming Chen and Ye Zhu and Bolong Huang and Zhanxi Fan}, doi = {10.1002/anie.202504641}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced p–d orbital coupling in unconventional phase RhSb alloy nanoflowers for efficient ammonia electrosynthesis in neutral media}, volume = {64}, year = {2025}, }
• (2025). Dynamic borate esterification for evolved supramolecular chirality and chiral optics. ANGEW, 64(23), e202504617. (www)

  @article{ , abstract = {Topological chemical reactions in confined environments offer unique opportunities for constructing dynamically tunable crystalline materials and architecturally defined polymers. However, their potential within functional supramolecular systems and chiral materials remains largely untapped. In this work, we introduce, for the first time, a borate esterification reaction to achieve dynamic modulation of supramolecular chirality and chiroptical properties under aggregation conditions. Pyrene-phenylalanine derivatives, following functionalization with phenylboronic acid groups, coassemble with catechol-functionalized pyrene derivatives. This coassembly undergoes spontaneous and highly efficient borate esterification under ambient conditions, inducing nanoscale morphological evolution, and an inversion of supramolecular chirality. Both experimental results and DFT-based computations reveal that the supramolecular chirality inversion is primarily driven by a transition from π–π stacking to CH–π interactions between pyrene moieties. This coassembly-borate esterification process represents a powerful integration of noncovalent assembly and covalent chemistry, providing a versatile platform for the design of soft materials and chiral functional systems. Moreover, the introduction of alizarin derivatives containing catechol motifs enables the transfer of circularly polarized luminescence (CPL), resulting in tunable emission shifts from blue and cyan to red. This work broadens the functional scope of chiral luminescent materials and opens new avenues for their application.}, archive = {J_ANGEW}, author = {Zhuoer Wang and Changyu Chu and Aiyou Hao and Pengyao Xing}, doi = {10.1002/anie.202504617}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504617}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic borate esterification for evolved supramolecular chirality and chiral optics}, volume = {64}, year = {2025}, }
• (2025). High performance electron acceptors containing transition metals. ANGEW, 64(23), e202504616. (www)

  @article{ , abstract = {A novel molecular platform characteristic of multiple transition metals (CH─Zn, CH─Ni, CH─Pt) on conjugated backbones is first established as high-performance electron acceptors. The CH─Pt-based ternary organic photovoltaics render an excellent power conversion efficiency surpassing 20%, more importantly, the unexplored dependency of central metals on intrinsic physicochemical properties of acceptors, nanoscale morphologies of donor/acceptor blends and final photovoltaic outcomes is fully disclosed. By demonstrating such a rare case of metal-containing acceptor, our work provides insight into whether metal complexes can serve as the building blocks of high-performance acceptors and gives guidance to rational design of metal-containing acceptors.}, archive = {J_ANGEW}, author = {Zheng Xu and Shuhui Ding and Wendi Shi and Wenkai Zhao and Xiangjian Cao and Zhaoyang Yao and Yaxiao Guo and Guankui Long and Chenxi Li and Xiangjian Wan and Yongsheng Chen}, doi = {10.1002/anie.202504616}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High performance electron acceptors containing transition metals}, volume = {64}, year = {2025}, }
• (2025). Electronic structure tuning in Cu–Co dual single atom catalysts for enhanced COOH* spillover and electrocalytic CO2 reduction activity. ANGEW, 64(23), e202504423. (www)

  @article{ , abstract = {The development of efficient electrocatalysts for CO 2 reduction to CO is challenging due to competing hydrogen evolution and intermediate over-stabilization. In this study, a Cu–Co dual single-atom catalyst (CuCo-DSAC) anchored on carbon black was synthesized via scalable pyrolysis. The catalyst achieves 98.5% CO Faradaic efficiency at 500 mA cm −2 , maintaining > 95% selectivity across a 400 mV window with < 6% decay over 48 h, which is superior to the corresponding single-atom control samples. In situ spectroscopy and DFT calculations reveal a synergistic mechanism: Co sites activate CO 2 and stabilize *COOH intermediates, while adjacent Cu sites facilitate CO desorption by lowering the energy barrier through charge redistribution. This dynamic buffer system mitigates active-site blocking and suppresses HER by weakening H adsorption. The electronic interplay between Cu and Co optimizes intermediate energetics, enabling industrial-level performance. This work demonstrates the potential of tailored dual-site architectures for complex electrocatalytic processes, offering a promising approach to overcoming traditional limitations.}, archive = {J_ANGEW}, author = {Yang Yang and Wenjun Zhang and Guangchen Wu and Qiang Huang and Jinghong Wen and Dingsheng Wang and Mingyang Liu}, doi = {10.1002/anie.202504423}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504423}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic structure tuning in Cu–Co dual single atom catalysts for enhanced COOH* spillover and electrocalytic CO2 reduction activity}, volume = {64}, year = {2025}, }
• (2025). Bio-inspired self-activating polydimethylsiloxane-modified CrOx/Al2O3 catalyst for acetylene semihydrogenation. ANGEW, 64(23), e202504399. (www)

  @article{ , abstract = {Biomimetic approach is a nature-driven strategy for designing functional materials to meet the industrial challenges. Here we demonstrate the bio-inspired discovery of a self-activating catalyst, with polydimethylsiloxane anchored over the surface of CrO x /Al 2 O 3 , exhibiting comparable performance with noble metallic catalysts for acetylene semihydrogenation. In addition, the dynamic movement of polymer chains with high flexibility renders the catalyst to impose proactive perturbation to the undesired coke precursors generated in reaction, analogous to the function of hair-like cilia on the surface of respiratory epithelial cells, thus avoiding the site-blocking induced by carbonaceous deposits and sustaining the catalyst stable for 1000 h without any deactivation. This study paves the way to develop other heterogeneous catalysts with high efficiency and durability via mimicking the innate defense mechanism of natural organisms.}, archive = {J_ANGEW}, author = {Chenyang Shen and Yibo Wang and Jun Yao and Fengfeng Li and Feifei Mei and Zhewei Zhang and Huili Lu and Xuefeng Guo and Luming Peng and Nianhua Xue and Yan Zhu and Zhaoxu Chen and Weiping Ding}, doi = {10.1002/anie.202504399}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504399}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bio-inspired self-activating polydimethylsiloxane-modified CrOx/Al2O3 catalyst for acetylene semihydrogenation}, volume = {64}, year = {2025}, }
• (2025). Linkages chemistry of covalent organic frameworks in photocatalysis and electrocatalysis. ANGEW, 64(23), e202504355. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have emerged as promising candidates for electrocatalysis and photocatalysis applications due to their structurally ordered architectures and tunable physicochemical properties. In COFs, organic building blocks are linked via covalent bonds, and the structural and electronic characteristics of COFs are critically governed by their linkage chemistry. These linkages influence essential material attributes including surface area, crystallinity, hydrophobicity, chemical stability, and the optoelectronic behavior (e.g., photoelectron separation efficiency, electron conductivity, and reductive activity), which collectively determine catalytic performance in energy conversion systems. A systematic understanding of linkage engineering in COFs not only advances synthetic methodologies but also provides innovative solutions to global energy and environmental challenges, thereby accelerating the development of sustainable technologies for clean energy production and environmental remediation.}, archive = {J_ANGEW}, author = {Xiubei Yang and Qing Xu and Wei Wei and Gaofeng Zeng}, doi = {10.1002/anie.202504355}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504355}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Linkages chemistry of covalent organic frameworks in photocatalysis and electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Insertion of nitriles into a Gold(III)/Carbene bond: A direct and powerful entry to imino-substituted carbenes. ANGEW, 64(23), e202504162. (www)

  @article{ , abstract = {Strikingly, very little is known so far about reactive gold(III) carbenes. They have been proposed as key intermediates in a few reactions but remain chemical curiosities. Taking into account the enhanced electrophilicity of cationic Au(III) carbene complexes, we were intrigued by their reactivity with nitriles. Thus, we discovered a simple and efficient entry to imino-substituted carbenes. The transient (N^C^C)Au(III)←:CH(dmp) + carbene readily reacts with acetonitrile, benzonitrile, and diisopropyl cyanamide, affording stable and isolable Au(III) carbene complexes. Here, the imino group acts either as a strongly π-donating or a spectator substituent. Ligand exchange at Au(III) or protodeauration/deprotonation provides access to the corresponding free species, which display dual imino-carbene / nitrile-ylide reactivity, as substantiated by stoichiometric and catalytic dimerization, O─H insertion and [3 + 2] cycloaddition reactions.}, archive = {J_ANGEW}, author = {Rui Wei and Nina Albouy and Sonia Mallet-Ladeira and Karinne Miqueu and Didier Bourissou}, doi = {10.1002/anie.202504162}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insertion of nitriles into a Gold(III)/Carbene bond: A direct and powerful entry to imino-substituted carbenes}, volume = {64}, year = {2025}, }
• (2025). Low-entropy and fast-li+-conducting electrolyte with cascade reaction-induced robust interphase for fast-charging lithium metal batteries. ANGEW, 64(23), e202504116. (www)

  @article{ , abstract = {Lithium metal is considered the most promising next-generation anode, while its fast-charging application is hindered by the problems of dendrite growth and side reactions. Herein, a low-entropy electrolyte with cascade reaction-induced stable interphase and fast Li + transport kinetics is proposed to provide excellent fast-charging performance of lithium metal batteries. In this electrolyte with an extremely simple formula, only two co-solvents with a lithium salt are used without any other additives. Fast lithium transport and desolvation kinetics are maintained, owing to the solvents’ low viscosity and weak interaction with lithium. Particularly, the intermediate products of lithium salt can further promote rapid defluorination of the F-containing solvent to form LiF, constructing a LiF-rich interphase. Fast Li + transport kinetics and robust interphase enable the fast-cycling performance of lithium metal anodes. The Li||Li symmetric cell can even withstand a high current density of 10 mA cm −2 . Good cycling stability under fast charging is also achieved with a capacity of 123 mAh g −1 maintained with a capacity retention rate reaching 90% after 200 cycles at a charging rate of 6C. Our results demonstrate a simple yet effective electrolyte design strategy facilitating the fast cycling of lithium metal batteries.}, archive = {J_ANGEW}, author = {Yao Li and Tianyang Xue and Jin Yan and Yi Chen and Keqing Shi and Tong Lian and Ji Qian and Renjie Chen}, doi = {10.1002/anie.202504116}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504116}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-entropy and fast-li+-conducting electrolyte with cascade reaction-induced robust interphase for fast-charging lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Photo-self-fenton reaction mediated by silver single atom and cluster photocatalysts for highly selective generation of singlet oxygen toward efficient organic wastewater treatment. ANGEW, 64(23), e202504028. (www)

  @article{ , abstract = {The persistent organic pollutants in wastewater have caused a heavy threat to ecosystems and humans, but selective removal of these pollutants still faces challenges due to low efficiency, extra addition of oxidation agents, and many highly toxic intermediate products. Herein, we report an efficient, fast kinetic conversion via a photo-self-Fenton-like system of *OOH intermediate-involved oxidation pathway with a high selection generation of singlet oxygen ( 1 O 2 ) from the novel in situ H 2 O 2 heterolytic activation route for the first time. The single-atom and cluster-doped zinc oxide (Ag SA –Ag C /ZnO) was successfully synthesized to achieve the 100% degradation yield and 80% total of carbon (TOC) of the p -chlorophenol (4-CP) as the typical pollutant under solar-light irradiation and exhibit long-term activity in a self-designed photo-Filter reactor for 4-CP degradation. It was attributed to the accelerated cycles from Ag high δ+ site to Ag low δ+ site in Fenton-like catalysis, achieving the rapid selection conversion from the H 2 O 2 heterolytic cleavage to ∼100% 1 O 2 via the intermediate *OOH at the Ag SA sites for ring-opening reaction and reactive H* at the Ag clusters sites for dechlorination reaction, respectively. This discovery gives the deep understanding of the high-performance photo-self-Fenton reaction through in situ cycles of variable metals for the organic contaminants treatment.}, archive = {J_ANGEW}, author = {Di Luo and Han Xiao and Yupeng Yang and Jiaxing Li and Yixing Wang and Xiaoru Huang and Mixuan Zhang and Lihui Wang and Jiarui Yang and Jiangzhi Zi and Zichao Lian and Guisheng Li and Hexing Li}, doi = {10.1002/anie.202504028}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202504028}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-self-fenton reaction mediated by silver single atom and cluster photocatalysts for highly selective generation of singlet oxygen toward efficient organic wastewater treatment}, volume = {64}, year = {2025}, }
• (2025). Heteroatom-doping engineering of fused olympic cations: Metal-free modular syntheses and NIR-II radicals with mixed Aromatic/Antiaromatic characters. ANGEW, 64(23), e202503989. (www)

  @article{ , abstract = {Heteroatom-doping polycyclic aromatic hydrocarbons have attracted immense attention owing to their fascinating optoelectrical properties. However, precise heteroatom-doping engineering and fabricating charged polycyclic aromatic scaffolds remain challenging and far from satisfactory. Herein, a new family of nitrogen and sulfur/oxygen dual-doping fused Olympic heterocyclic cations (FPT/FPOs) are modularly synthesized employing an efficient and convenient metal-free protocol. Tunable optical and redox properties can be achieved by rational structural editing. Compared with their half-fused counterparts, FPTs and FPOs hold higher redox stability and can undergo single-electron reduction to form delocalized neutral radicals, exhibiting NIR-II absorptions around 1300–1400 nm and unexpected mixed aromatic/antiaromatic characters. It is anticipated that this line of research provides a new approach for heteroatom-doping engineering and constructing novel charged π-molecules, with deeper insights into their redox-amphoteric features and aromaticity manipulation.}, archive = {J_ANGEW}, author = {Yuanchen Shen and Huacheng Yu and Jiantao Zhao and Jiang-Fei Xu and Xi Zhang}, doi = {10.1002/anie.202503989}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503989}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heteroatom-doping engineering of fused olympic cations: Metal-free modular syntheses and NIR-II radicals with mixed Aromatic/Antiaromatic characters}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of euphane triterpenoids using metal-catalyzed hydrogen atom transfer. ANGEW, 64(23), e202503943. (www)

  @article{ , abstract = {Euphane triterpenoids are widely distributed in nature and show various intriguing bioactivities, but relatively few synthetic routes to them have been described. Here, we report asymmetric convergent total syntheses of euphanes involving two triterpenoids and two nortriterpenoids: euphol, 25,26,27-tris nor -3β-hydroxy-euphan-24-al, euphorbiumrin D, and 3-oxo-tirucall-7-ene-3,20-dione. The syntheses employ an enantioselective Antilla allylboration and intramolecular radical cyclization to construct ring A, a palladium-catalyzed Liebeskind stannane-thioester coupling to connect ring A with the bicyclic CD system, and a novel radical cascade with metal-catalyzed hydrogen atom transfer (MHAT) to complete the polycyclic architecture. The late-stage syntheses of both triterpenoids feature a diimide reduction and a MHAT/1,5-hydrogen transfer cascade to diastereoselectively forge the C20 and C17 stereogenic centers.}, archive = {J_ANGEW}, author = {Chengying Zhou and Weitian Qin and Canhui Tu and Yunxuan Chen and Shaomin Fu and Bo Liu}, doi = {10.1002/anie.202503943}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503943}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of euphane triterpenoids using metal-catalyzed hydrogen atom transfer}, volume = {64}, year = {2025}, }
• (2025). Controlling the chirality of metallo-cages by manipulating the stereochemistry of the metal centers. ANGEW, 64(23), e202503833. (www)

  @article{ , abstract = {Precise control over the chirality of metallo-cages by manipulating the stereochemistry of metal centers is important in many practical applications, but is extremely challenging. In this study, two isostructural metallo-cuboctahedra ( 1 -Zn II 12 L1 8 and 2 -Cd II 12 L1 8 ) have been assembled using ligand L1 and two kinds of metal ions (Zn II and Cd II ) with similar coordination lability. The chiral-induction by the same guests ( D -/ L -camphorsulfonate, D -/ L -SCS) results in a completely opposing stereochemical output of 1 and 2 : D -SCS induced host–guest complex of [ D -SCS⊂Δ 12 – 1 ] and [ D -SCS⊂Λ 12 – 2 ], respectively, with reverse handedness. The distinct stereochemical configuration of metallo-cuboctahedra can be manipulated by participant metal ions that exhibit similar dynamics. Furthermore, a subtle variation of the ligand peripheral substituent group facilitates spontaneous resolution of metallo-cuboctahedra 3 -Zn II 12 L2 8 from a racemic mixture as ( R 24 , Λ 12 )- 3 /( S 24 , Δ 12 )- 3 enantiopure entities. The dynamic stereochemistry of M II 12 L 8 cuboctahedra described in this work allows a chiral manipulation based on the nature of metal centers and ligands, enabling the design and control of the chirality of metallo-cages.}, archive = {J_ANGEW}, author = {Yu-Qing Li and Lei Fu and Zhiyuan Jiang and Ermeng Han and Tian Li and Qixia Bai and Ting-Zheng Xie and Zhe Zhang and Pingshan Wang and Tun Wu}, doi = {10.1002/anie.202503833}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503833}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlling the chirality of metallo-cages by manipulating the stereochemistry of the metal centers}, volume = {64}, year = {2025}, }
• (2025). Solid-state photoconversion of a discrete mixed Iodine(I) system to a 1D polymer. ANGEW, 64(23), e202503763. (www)

  @article{ , abstract = {The first example of a mixed halogen(I) complex ( 2 ), containing three distinct iodine(I) moieties ([N―I―N] + , O―I―N, and [O―I―O] − ) within the same structure, was synthesized with 4-styrylpyridine (4-stypy) and 3,4,5,6-tetrafluorophthalate as the stabilizing Lewis bases. This complex was observed to be in equilibrium with its respective bis (OIN) complex ( 1a ), with isolated samples of 2 also being found to convert to 1a in solution. Upon UV irradiation of 2 , a single-crystal-to-single-crystal [2 + 2] cycloaddition reaction was observed, converting the discrete salt 2 to the 1D polymer 5 . Complex 5 retained all the iodine(I) moieties from prior to photoconversion and represents the first example of nondestructive photoconversion of a halogen(I) complex. To facilitate comparisons to 2 and 5 , several additional closely related iodine(I) complexes were synthesized, with the iodine(I) complexes characterized by NMR ( 1 H, 1 H- 15 N HMBC) and SCXRD, as well as by Raman and IR spectroscopy for 2 , 5 , and their close structural analogue 1a .}, archive = {J_ANGEW}, author = {Jas S. Ward and Aaron Mailman}, doi = {10.1002/anie.202503763}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503763}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solid-state photoconversion of a discrete mixed Iodine(I) system to a 1D polymer}, volume = {64}, year = {2025}, }
• (2025). Biomimetic Adhesion/Detachment using layered polymers with light-induced rapid shape changes. ANGEW, 64(23), e202503748. (www)

  @article{ , abstract = {Geckos achieve rapid and efficient adhesion and detachment on various surfaces within milliseconds due to the hierarchically structured fibrillar architecture of their toe pads. Extensive research has focused on developing adhesive materials that mimic these micro-nano structures. However, no conventional adhesives have matched the performance of their natural counterparts, which are both non-degrading and self-cleaning. Here, we develop a chemically crosslinked polymer film with a nanoscale layered structure that exhibits high-speed switching of mechanical motions (expansion and contraction) in equation both forward and reverse directions through controlled ultraviolet (UV) irradiation. Under UV light on/off switching, the film shows reversable shape changes in the direction perpendicular to the molecular alignment. These photoresponsive molecular movements in the film is demonstrated for remote control in a smart adhesion system with rapid responsiveness and high reproducibility. The films respond to UV light to release picked-up objects and immediately regain their adhesion when the UV light ceases. Additionally, we propose the working principles and mechanisms of these reusable adhesive films, providing new insights into the development of smart soft materials. The material's rapid deformation, high responsiveness, and flexibility make it a promising candidate for light-controlled object transport and remote-controlled robotics.}, archive = {J_ANGEW}, author = {Youfeng Yue and Yasuo Norikane and Eiji Nishibori}, doi = {10.1002/anie.202503748}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503748}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biomimetic Adhesion/Detachment using layered polymers with light-induced rapid shape changes}, volume = {64}, year = {2025}, }
• (2025). Prebiotic interconversion of pyruvate and lactate over zeolite-supported ni catalyst. ANGEW, 64(23), e202503747. (www)

  @article{ , abstract = {Submarine hydrothermal vents harbor diverse microbial communities and have long intrigued researchers studying the origin of life. Transition metals in these environments can be reduced by serpentinization, potentially forming zeolite-supported transition metal nanoparticles capable of driving prebiotic chemistry. This inorganic structure could catalyze biochemical reactions, including converting metabolically crucial pyruvate before the emergence of biological processes. This study explores the catalytic interconversion of pyruvate and lactate, mediated by lactate dehydrogenase in biochemical systems, using inorganic zeolite Y-supported Ni nanoparticles (Ni/Y) under mild hydrothermal vent conditions. Our results demonstrate that Ni/Y effectively catalyzes the hydrogenation of pyruvate in an inert environment, facilitated by the in situ generation of H₂ through an autocatalytic reaction between Ni/Y and H₂O. Post-reaction analysis by X-ray absorption spectroscopy (XAS) revealed structural transformations in the catalyst, including the formation of unique nickel oxide and hydroxide species, along with extra-framework aluminum from zeolite dealumination, resulting in a thin amorphous nickel oxide/hydroxide layer. Notably, Ni/Y also enables the oxidative reconversion of lactate to pyruvate under atmospheric conditions—an essential reaction catalyzed by lactate dehydrogenase in biological systems. These findings underscore the potential prebiotic role of Ni/Y, suggesting they may have catalyzed the synthesis of key metabolic intermediates.}, archive = {J_ANGEW}, author = {Youngdong Song and Eko Budiyanto and Ashwani Kumar and Gautier Landrot and Harun Tüysüz}, doi = {10.1002/anie.202503747}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503747}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Prebiotic interconversion of pyruvate and lactate over zeolite-supported ni catalyst}, volume = {64}, year = {2025}, }
• (2025). Robust solid electrolyte interphase engineered by catalysis chemistry toward durable anode-free sodium metal batteries. ANGEW, 64(23), e202503691. (www)

  @article{ , abstract = {Anode-free sodium metal batteries (AFSMBs) are considered one of the most promising large-scale energy storage systems due to their extremely high energy density. Nonetheless, their practical application is hindered by the uncontrolled growth of sodium dendrites. Constructing a mechanically robust solid electrolyte interphase (SEI) is an effective strategy to suppress dendrite formation. Herein, we report a catalysis chemistry approach to construct an ultra-thin (∼ 5 nm), NaF-rich and high-strength (203 MPa) SEI layer by introducing Ru catalytic sites on the current collector, which promotes rapid Na⁺ diffusion and effectively inhibits dendrite growth. Benefiting from this design, the Ru modified-Cu//Na asymmetric cells exhibit exceptional cycling stability over 2000 h (1000 cycles at 2 mA cm −2 , 2 mAh cm −2 ). Furthermore, the AFSMBs with Ru modified-Cu current collector also deliver excellent cycling performance and maintains nearly 98.1% capacity retention after 100 cycles at 0.5 C. The results demonstrate great potential of catalysis chemistry in developing advanced sodium metal anodes and provide a new perspective to engineering efficient SEI toward battery applications.}, archive = {J_ANGEW}, author = {Chongyang Hao and Xiaomin Zhang and Zixu He and Mingxia Gao and Yongfeng Liu and Hongge Pan and Wenping Sun}, doi = {10.1002/anie.202503691}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503691}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust solid electrolyte interphase engineered by catalysis chemistry toward durable anode-free sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Chiral zinc sulfide nanoparticles scavenging reactive oxygen species for remodeling intestinal homeostasis. ANGEW, 64(23), e202503654. (www)

  @article{ , abstract = {Elevated levels of reactive oxygen species (ROS) and gut microbiota dysbiosis are crucial factors that exacerbate inflammatory bowel disease (IBD). To address this, we successfully synthesized zinc sulfide nanoparticles (ZnS NPs) with a particle size of approximately 500 nm and a maximum g -factor of 0.07, utilizing l -/ d -cysteine as chiral ligands. Chirality gives NPs unique bioactivity. These chiral ZnS NPs could enter macrophages through the CD44 and clathrin pathways, which enhanced the ability to scavenge ROS, in turn significantly inhibited the NF-κB and NLRP3 signaling pathways, thereby reducing the secretion of TNF-α, IL-6, and IL-1β, while upregulating IL-10. In vivo experimental data showed that l -ZnS NPs outperformed 5-aminosalicylic acid, significantly improving body weight, reducing the IBD activity index, and attenuating tissue damage. Concurrently, l -ZnS NPs exhibited a marked prophylactic effect. The benchmark studies verified that l -ZnS NPs increased the abundance of the beneficial Lachnospiraceae NK4A136 by 10.55-fold and decreased harmful Enterobacter by 2914.00-fold, thereby reshaping the intestinal microecological balance. Pharmacokinetic and biosafety assessments confirmed the safety of l -ZnS NPs. Our findings indicate that chiral ZnS NPs hold great potential as nanodrugs for the treatment and prevention of IBD, providing an important foundation for the development of IBD therapeutic strategies.}, archive = {J_ANGEW}, author = {Jun Luo and Baimei Shi and Changlong Hao and Maozhong Sun and Liguang Xu and Hua Kuang and Aihua Qu}, doi = {10.1002/anie.202503654}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral zinc sulfide nanoparticles scavenging reactive oxygen species for remodeling intestinal homeostasis}, volume = {64}, year = {2025}, }
• (2025). Removing α-H in carboxylate-based electrolytes for stable lithium metal batteries. ANGEW, 64(23), e202503616. (www)

  @article{ , abstract = {Although carboxylate esters greatly improve the cold weather performance of graphite-based lithium-ion batteries utilized in arctic expeditions, the underlying cause of the incompatibility between carboxylates and lithium (Li) anodes has not been sufficiently explained, resulting in the greatly restricted usage of carboxylate in lithium metal batteries (LMBs). Herein, we reveal the serious parasitic reactions between carboxylate α-H atoms and Li metal are the culprits that render carboxylate-based ineffectiveness for LMBs. By replacing all α-H atoms with fluorine atoms and methyl groups, we successfully construct inert carboxylates and find the ions/molecules distribution in electric-double-layer (EDL) can be manipulated at a molecular-level. The unique structure ensuring more anions are positioned closer to the Li surface in the EDL of the inert carboxylate-based electrolyte, the morphology of the deposited Li is significantly regulated and the chemical corrosion gets effectively inhibited, as a consequence of remarkable extending lifespan of carboxylate-based LMBs with routine salt concentration and few additives. More generally, using carboxylates lacking α-H atoms offer a realistic approach to increase the variety of solvents that can be used in LMBs electrolytes.}, archive = {J_ANGEW}, author = {Yi Yang and Le-Geng Yu and Yu-Xin Huang and Xiao-Qing Ding and Zhou-Qing Xue and Zeheng Li and Yu-Xing Yao and Shuo Zhang and Lei Xu and Xue-Fei Wen and Jian Pei and Chong Yan and Jia-Qi Huang}, doi = {10.1002/anie.202503616}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Removing α-H in carboxylate-based electrolytes for stable lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Fullerene-buffered electron shuttle of Ru/RuO2 with switchable active sites enables robust and efficient bifunctional alkaline water electrolysis. ANGEW, 64(23), e202503608. (www)

  @article{ , abstract = {Developing highly-efficient and robust bifunctional electrocatalyst for overall water splitting (OWS) is desirable, but it confronts long-term challenge in the local structural reconstruction of catalyst during the hydrogen and oxygen evolution reaction (HER and OER). As inspired by the stable acid–base buffer system in human life, here we construct an electron buffer system to well address the key issue of structural reconstruction, in which the charge-buffered fullerene renders Ru-based active species to be reversibly shuttled between Ru and RuO 2 during HER and OER. Consequently, the as-prepared Ru-RuO 2 /C 60- x catalyst exhibits overpotentials of merely 7 and 194 mV at 10 mA cm −2 for HER and OER in alkaline conditions, respectively. The photovoltaic-driven OWS device with a solar-to-hydrogen (STH) efficiency of 18.9% and an anion exchange membrane water electrolysis (AEMWE) system with good robustness was fabricated based on Ru-RuO 2 /C 60- x . It was unraveled by in situ/operando spectroscopy and theoretical calculation that the significantly promoted performance of water electrolysis benefits from the fullerene-based electron shuttle effect on inhibition of structural reconstruction and electronic structural modulation of active sites as well as adsorption energy of the reaction intermediates. Our work may open an avenue to develop efficient and robust bifunctional electrocatalyst for promising industrial water electrolysis.}, archive = {J_ANGEW}, author = {Ying Wang and Jizhang Wang and Jilong Xu and Xianlin Qu and Liping Lin and Lu Zhao and Qingqing Liu and Ying Wei and Xu Li and Qunzhi Ma and Jun Zhang and Wenjun Fan and Bin Wu and Xingang Kong and Jianfeng Huang and Yi Wang and Yifan Ye and Yongqiang Feng and Fuxiang Zhang}, doi = {10.1002/anie.202503608}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fullerene-buffered electron shuttle of Ru/RuO2 with switchable active sites enables robust and efficient bifunctional alkaline water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Fluid chemistry of metal halide perovskites. ANGEW, 64(23), e202503593. (www)

  @article{ , abstract = {Solution-processed metal halide perovskites (MHPs) have been rapidly developed worldwide, with much attention to fluid dynamic, fluid crystallization, and fluid interfaces, all falling within the realm of fluid chemistry. It is widely recognized that the theory of fluid chemistry has been proven to provide an effective means for the improvement of perovskite crystallization and the enhancement of perovskite solar cells (PSCs) performance. In this review, the fluid behavior, microfluidic synthesis, and aging process of perovskite materials are first investigated, with emphasis on the related improvement methods and chemical mechanisms. Second, the internal crystallization chemistry, external interface chemistry, and the large-area PSCs based on the fluid chemistry are discussed. Finally, four specific directions for future studies of fluid chemistry of MHPs are proposed, aiming to harness the theoretical advantages of fluid chemistry and contribute to the industrialization of PSCs.}, archive = {J_ANGEW}, author = {Changshun Chen and Qing Yao and Jinpei Wang and Chenxin Ran and Lingfeng Chao and Yingdong Xia and Yonghua Chen}, doi = {10.1002/anie.202503593}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluid chemistry of metal halide perovskites}, volume = {64}, year = {2025}, }
• (2025). An activatable caged palladium nanocomposite for targeted cancer therapy. ANGEW, 64(23), e202503485. (www)

  @article{ , abstract = {Pd-based intracellular catalysis has attracted increasing interest in modulating biological processes or disease treatment. The unsatisfactory catalytic efficiency arising from limited active sites and poor water solubility of palladium nanoparticles (Pd NPs) and their “always on” catalytic activities pose, however, significant limitations. Herein, we develop a high-performance nanocomposite based on ultrafine Pd NPs confined within molecular cages, and incorporated with glucose oxidase (GOx) and AS1411 aptamer-modified hyaluronic acid (HA). The cage-confined strategy enables facile synthesis of ultrafine Pd NPs with more accessible active sites, significantly improving the catalytic activities of Pd NPs for enhanced bioorthogonal catalysis. Importantly, the nanocomposite exhibits targeting ability and activatable activity in response to both the acidic pH and hyaluronidase overexpressed in the tumor environment, enabling selective drug synthesis. Besides, it features CAT-, OXD-, and GPx-like activities, promoting reactive oxygen species (ROS) generation and intracellular GSH depletion to elevate oxidative stress for enhanced therapy. The cage-confined configuration makes it possible to establish metal-based intracellular catalytic systems with high performance, enabling the synthesis of desired molecules for effective disease theranostics.}, archive = {J_ANGEW}, author = {Jiadong Tang and Chi Li and Wenjie Ma and Zhengnuo Ba and Zhubin Hu and Itamar Willner and Chen Wang}, doi = {10.1002/anie.202503485}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503485}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An activatable caged palladium nanocomposite for targeted cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Cold-optimized zinc-ion batteries: Enhanced stability at −5 °C. ANGEW, 64(23), e202503435. (www)

  @article{ , abstract = {Aqueous zinc-ion batteries (AZIBs) have been extensively studied under room and ultralow temperature conditions. However, mechanism studies at intermediate temperature ranges remain limited. In this work, we investigate the electrochemical performance of an AZIB using a commonly employed 3 M ZnSO 4 electrolyte across the intermediate temperature range of 25 to −15 °C. Notably, we find that the battery with a double hydroxide cathode exhibits optimized performance at −5 °C, demonstrating significantly enhanced cycling stability compared to 25 °C. Mechanistic studies reveal that unfavorable H + -associated reactions at both the cathode and anode are effectively alleviated at −5 °C, contributing to improved cycling stability. Spectroscopic and theoretical analyzes show that changes in the electrolyte environment at −5 °C—such as reduced electrochemical activity of H 2 O, increased H-bond strength, and decreased total number of H bonds—impede H + diffusion through H-bond network via the Grotthuss mechanism. These effects collectively suppress harmful H + -associated reactions, allowing Zn 2+ insertion/deinsertion to dominate the charge storage process. This work provides valuable insights into the enhanced performance of AZIBs at sublow temperatures and presents opportunities for extending battery operation in near-freezing environments.}, archive = {J_ANGEW}, author = {Jianming Meng and Yulai Lin and Yuqing Wang and Peng Hei and Ya Sai and Jing Wang and Xiaoqi Sun and Xiao-Xia Liu and Yu Song}, doi = {10.1002/anie.202503435}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503435}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cold-optimized zinc-ion batteries: Enhanced stability at −5 °C}, volume = {64}, year = {2025}, }
• (2025). Coupling zn2+ ferrying effect with anion–π interaction to mitigate space charge layer enables ultra-high utilization rate zn anode. ANGEW, 64(23), e202503396. (www)

  @article{ , abstract = {A major dilemma faced by Zn anodes at a high zinc utilization rate (ZUR) is the insufficient supply of ionic carriers that initiate the space charge layer (SCL) subject to the rampant growth of Zn dendrites. Herein, an “anion–cation co-regulation” strategy, associated with a fundamental principle for screening potential electrolyte additives coupling the Zn 2+ ferrying effect with anion-retention capability, is put forward to construct dendrite-free, high-ZUR Zn anode. Taking ninhydrin-modified ZnSO 4 system as a proof-of-concept, the multiple zincophilic polar groups of ninhydrin facilitate the transport of Zn 2+ ions, while its electron-deficient aromatic ring retains SO 4 2− counterions via anion–π interaction, constructing an ion-rich interface that minimizes the SCL-driven Zn deterioration. Consequently, the Zn anode can endure ∼240 h continuous cycling at an ultrahigh ZUR of 87.3%. The superiority brought by ninhydrin is further reflected by the ultralong cycling durability of Zn-I 2 batteries (over 100 000 cycles). Even at an ultralow N/P ratio of 1.1 (∼90.6% ZUR), the battery with a capacity of ∼5.27 mAh cm −2 can still sustain for 350 cycles, which has been hardly achieved in aqueous Zn batteries. Furthermore, the effectiveness of this strategy is fully validated by a series of additives sharing similar fundamentals.}, archive = {J_ANGEW}, author = {Zhaoyu Zhang and Xiaojia Lan and Guoli Liao and Wencheng Du and Yufei Zhang and Minghui Ye and Zhipeng Wen and Yongchao Tang and Xiaoqing Liu and Cheng Chao Li}, doi = {10.1002/anie.202503396}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503396}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coupling zn2+ ferrying effect with anion–π interaction to mitigate space charge layer enables ultra-high utilization rate zn anode}, volume = {64}, year = {2025}, }
• (2025). A rigid, stable, and scalable aliphatic MOF adsorbent for efficient C2H2/CO2 separation with record acetylene packing density. ANGEW, 64(23), e202503317. (www)

  @article{ , abstract = {Integrating separation parameters such as high adsorption capacity and selectivity, moderate adsorption enthalpy ( Q st ), along with industrial factors including cyclic stability, cost-effectiveness, and scalability into a single adsorbent remains highly challenging due to inherent trade-offs among these properties. Herein, we strategically leverage the coordination modes of aliphatic ligands to significantly enhance C 2 H 2 /CO 2 separation performance. The structure flexibility and pore metrics are finely modulated by hydroxylated aliphatic acid (DLmal). As a result, the rigid Zn-bpy-DLmal exhibits an exceptional C 2 H 2 adsorption capacity of 1.4 mmol g −1 at 0.01 bar, high C 2 H 2 /CO 2 selectivity (49), and moderate C 2 H 2 Q st value (38.4 kJ mol −1 ). Notably, it achieves record-high C 2 H 2 packing densities of 347 g L −1 at 0.01 bar and 747 g L −1 at 0.5 bar. Furthermore, the scale-up production of Zn-bpy-DLmal to kilogram quantities has been successfully achieved at an estimated cost of $74 per kilogram. Dynamic breakthrough experiments confirm its practical C 2 H 2 /CO 2 separation performance with excellent cyclability under high flow rates and both dry and humid conditions. Moreover, two-bed pressure swing adsorption simulations demonstrate a high-purity C 2 H 2 (>99%) yield of 14.64 mol with a recovery of 88.2% per cycle.}, archive = {J_ANGEW}, author = {Shuangqing Shang and Zhenwei Zhou and Hao Wang and Yanan Wang and Xing Liu and Zhenglong Zhu and Yong Zeng and Cheng Liu and Hanting Xiong and Hao Liu and Fangxin Zhao and Jingwen Chen and Shixia Chen and Zhenyu Zhou and Jun Wang}, doi = {10.1002/anie.202503317}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503317}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A rigid, stable, and scalable aliphatic MOF adsorbent for efficient C2H2/CO2 separation with record acetylene packing density}, volume = {64}, year = {2025}, }
• (2025). Harnessing biofilm scaffold for structurally adaptative slippery surfaces with integrated antifouling and anticorrosion properties. ANGEW, 64(23), e202503295. (www)

  @article{ , abstract = {Artificial liquid-repellent surfaces are highly desirable to combat pervasive biofouling and corrosion in biological environments. However, existing strategies often suffer from slow binding kinetics and harsh fabrication conditions, hindering the concurrent integration of liquid repellency, universal adhesion, and robust flexibility. Herein, we report that it is possible to engineer microbial biofilms as eco-friendly, cohesive, and flexible materials for omniphobic slippery coatings fulfilling all these requirements. Unlike conventional synthetic slippery coatings requiring laborious surface pretreatments, biofilm sheets formed on demand assemble a durable nanotextured framework on diverse substrates with multiple material categories and surface topologies, serving as hydrophobic lubricant reservoirs. Employing this renewable material enables the scalable and sustainable coating production. The resulting optically transparent and highly flexible coatings manifest exceptional self-cleaning properties, readily shedding both waterborne and oily liquids over a broad viscosity range. Notably, the synergy between the corrosion-protective extracellular matrix and nonstick slipping motion confers unprecedented antibiofouling efficacy and corrosion resistance. This study offers a distinctive perspective on harnessing ubiquitous native biofilms as biomaterials for self-adaptive coatings, facilitating tailored functionality across broad applications.}, archive = {J_ANGEW}, author = {Xiangyu Li and Runqing Zhang and Jingru Zhang and Qike Li and Zhiqun Yu and Zishuai Zhou and Shiman Lin and Zhong Li and Miaomiao Cui and Wenjie Zhao and Liping Wang and Fuhui Wang and Dake Xu}, doi = {10.1002/anie.202503295}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503295}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing biofilm scaffold for structurally adaptative slippery surfaces with integrated antifouling and anticorrosion properties}, volume = {64}, year = {2025}, }
• (2025). Non-carbonized pd single-atom catalyst supported on lignin-functionalized phenolic resin for potent catalytic transfer hydrogenation of lignin-derived aldehydes. ANGEW, 64(23), e202503195. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) depend significantly on their support properties, and organic polymers have emerged as promising candidates due to their tunable physicochemical properties and diverse functional groups. However, the high-temperature carbonization commonly required for conventional organic polymer-supported SAC fabrication often leads to the loss of these functional groups, thus weakening metal-support interactions and catalytic performance accordingly. Herein, we report a sustainable strategy to synthesize nitrogen-functionalized lignin-based phenolic resin (N-LPR) supports for stabilizing atomically dispersed palladium (Pd) without carbonization. Using ammonia solution (NH 3 ·H 2 O) as both the nitrogen source and catalyst, high molecular weight lignin fractions (L3) were transformed into N-L3PR-50% supports with a unique nano-chain-like structure, high surface area, and abundant amine groups, which can directly anchor Pd sites under room temperature. The resulting Pd@N-L3PR-50% catalyst achieved approximately 100% vanillin conversion and 97.91% selectivity for 2-methoxy-4-methylphenol at 80 °C with excellent cycle stability and adaptability to lignin-derived aldehydes, benefiting from the stable Pd-N coordination and the good adsorption capacity provided by the N-L3PR-50% support. Consequently, this work not only demonstrates a straightforward non-carbonation strategy to prepare lignin-based SACs for potent biomass-derived chemical transformations but also provides a novel avenue for the application of conventional multifunctional organic polymers as support for SACs.}, archive = {J_ANGEW}, author = {Tairan Pang and Zhenglong Xue and Guanhua Wang and Junkai Li and Wenjie Sui and Chuanling Si}, doi = {10.1002/anie.202503195}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503195}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-carbonized pd single-atom catalyst supported on lignin-functionalized phenolic resin for potent catalytic transfer hydrogenation of lignin-derived aldehydes}, volume = {64}, year = {2025}, }
• (2025). Antisolvent-regulated anionic coordination enabling stable li metal anode in urea-based electrolyte. ANGEW, 64(23), e202503162. (www)

  @article{ , abstract = {The fabrication of NO 3 − anion-participating solvation sheaths to derive inorganic-rich solid electrolyte interphase (SEI) layers is critical for enhancing the stabilization of lithium metal batteries (LMBs). However, the application of LiNO 3 salt is limited by its low solubility and the challenge of controlling NO 3 − coordination, primarily due to its high donor number. Herein, we demonstrate an antisolvent-enhanced anionic coordination effect in urea-based LiNO 3 electrolytes for boosting the cycling stability of LMBs. We find that the incorporation of 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (TTE) into these electrolytes enhances the interaction between the NO 3 − anion and urea-based solvent to Li + in the solvation sheath, resulting in an increase in ion-pair formation. This also induces a transformation of the NO 3 − anion from a monodentate to a bidentate coordination configuration, facilitating preferential nitrate reduction at the anode interface. The optimized electrolyte formulation demonstrates remarkable cycling stability in lithium metal anode, achieving 6000 h of operation in a Li||Li cell and a high Coulombic efficiency of 99.6% in a Li||Cu cell. In full-cell testing, Li||LiFePO 4 cells (N/P = 3) maintain 88% capacity retention after 100 cycles at 0.2C.}, archive = {J_ANGEW}, author = {Xiaopeng Pei and Ting Ou and Yiju Li and Yufan Xin and Lu Chen and Mengqi Wang and Junliang Du and Shaojun Guo and Ying Tan}, doi = {10.1002/anie.202503162}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antisolvent-regulated anionic coordination enabling stable li metal anode in urea-based electrolyte}, volume = {64}, year = {2025}, }
• (2025). Routes to pt derivatives of high-valent sulfur oxofluorides S(═O)2F, S(═O)F2, and S(═O)F3 by fluorination and oxygenation. ANGEW, 64(23), e202503153. (www)

  @article{ , abstract = {Metal derivatives of high-valent sulfur fluorides and oxofluorides can provid e fluorinated building blocks for materials science and bioactive compounds, but so far, such building blocks are elusive. The paper describes routes to access remarkable metal derivatives of S(═O) 2 F, S(═O)F 2 , and S(═O)F 3 by oxygenation or fluorination steps. The Pt(II) fluorido complex trans -[Pt(F)(SOF)(PCy 3 ) 2 ] ( 2 ) reacts with the Davis reagent (3-phenyl-2-(phenylsulfonyl)-1,2-oxaziridine) to yield the sulfuryl fluorido complex trans -[Pt(F)(SO 2 F)(PCy 3 ) 2 ] ( 4 ). Notably, the electrophilic fluorinating agent NFSI ( N -fluorobenzenesulfonimide) reacts with 2 to form trans -[Pt(F)(SOF 2 )(PCy 3 ) 2 ][NFSO 2 Ph] ( 5a ). By nucleophilic fluorination with TMAF (Me 4 NF) it is possible to fluorinate the sulfur center once more to give the complex trans -[Pt(F)(SOF 3 )(PCy 3 ) 2 ] ( 6 ) bearing an unprecedented SOF 3 ligand. Above 283 K, complex 6 shows a decomposition of the SOF 3 moiety to form trans -[Pt(F) 2 (PCy 3 ) 2 ] ( 7 ) and SOF 2 . The described complexes could represent a previously unknown class of transfer reagents for high-valent sulfur fluoride units.}, archive = {J_ANGEW}, author = {Ruben Jaeger and Ouchan He and Stefan Sander and Dilcan Dirican and Mike Ahrens and Thomas Braun}, doi = {10.1002/anie.202503153}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503153}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Routes to pt derivatives of high-valent sulfur oxofluorides S(═O)2F, S(═O)F2, and S(═O)F3 by fluorination and oxygenation}, volume = {64}, year = {2025}, }
• (2025). Interfacial mesochannels as cation pump for enhanced osmotic energy harvesting. ANGEW, 64(23), e202503110. (www)

  @article{ , abstract = {Membranes integrating 1D materials are rapidly emerging as highly promising platforms for osmotic energy harvesting. However, their power output is often constrained by insufficient ion selectivity. Herein, we demonstrate a cation pumping strategy by designing mesoporous silica coated multiwalled carbon nanotubes/aramid nanofiber (MCNTs@mSiO 2 /ANF) composite membranes as osmotic power generators. Cations can be initially enriched in the negatively charged and small-pore-sized (∼ 3 nm) interfacial mesopore channels, establishing a strong cation concentration gradient toward the interfiber nanochannels. The gradient continuously drives cations into the interfiber pores, facilitating charge separation, and improving ion selectivity. Additionally, the hydrophilic nature of the mesoporous silica shells promotes ion transport and contributes to high ion flux. Consequently, the fabricated MCNTs@mSiO 2 /ANF composite nanochannel membranes can deliver a notable power density of 8.24 W m −2 with an excellent ion selectivity of 0.91 under a 50-fold NaCl salinity gradient. Importantly, the membranes demonstrate long-term stability for osmotic energy capturing. When placed between natural seawater and river water, the composite membranes yield an impressive power density of 9.93 W m −2 , surpassing that of the state-of-the-art 1D material-based membranes. This work paves the way for the practical applications of nanofiber-based membranes in sustainable osmotic energy conversion.}, archive = {J_ANGEW}, author = {Yi Yang and Zirui Lv and Wanhai Zhou and Yiyue Zhao and Chaochao Yang and Yan Ai and Lipeng Wang and Zhihao Sun and Zaiwang Zhao and Peihua Yang and Wei Li and Dongliang Chao and Dongyuan Zhao}, doi = {10.1002/anie.202503110}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503110}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial mesochannels as cation pump for enhanced osmotic energy harvesting}, volume = {64}, year = {2025}, }
• (2025). Stabilizing surface lattice on− (0 < n < 2) for long-term durability of LiCoO2. ANGEW, 64(23), e202503100. (www)

  @article{ , abstract = {The instability of surface lattice O n − (0 < n < 2) in charged LiCoO₂ (LCO) limits its long-term cycling stability beyond 4.55 V versus Li/Li⁺. Herein, the spinel and rock-salt (RS) phases are constructed on LCO surface to stabilize lattice O n − , namely S-LCO and R-LCO, respectively. Upon long-term cycling at 4.6 V, the loss of lattice O n − leads to a progressive deterioration of surface spinel phase, which ultimately transforms into a strong Li + -blocking phase. In contrast, for R-LCO, the surface lattice O n − in the RS phase remains stable in long-term cycles. Theoretical calculations reveal that the migration barriers of lattice O n − are significantly higher in the RS phase than in the spinel phase. Due to the stabilized surface lattice O n − , the R-LCO||Li cell shows an impressive capacity retention of 78.6% after 1000 cycles at 4.6 V (at 1C rate) and superior floating charge durability at 45 °C. This study highlights the importance of surface structure tailoring in developing advanced LCO cathodes.}, archive = {J_ANGEW}, author = {Wenguang Zhao and Mingyang Li and Zijian Li and Hengyu Ren and Xiaohu Wang and Xingxing Yin and Wangyang Ding and Guojie Chen and Shiming Chen and Haocong Yi and Shunning Li and Jun Wang and Dong Zhou and Lin Zhou and Hai Lin and Bin Fei and Feng Pan and Qinghe Zhao}, doi = {10.1002/anie.202503100}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503100}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilizing surface lattice on− (0 < n < 2) for long-term durability of LiCoO2}, volume = {64}, year = {2025}, }
• (2025). Exceptionally high two-photon absorption cross sections in quinoidal diazaacene-bithiophene derivatives. ANGEW, 64(23), e202503073. (www)

  @article{ , abstract = {This study addresses the two-photon absorption (2PA) properties of (azaacene-annulated) heterophenoquinones through a synergistic approach combining detailed experimental and theoretical analyses. Exceptionally large 2PA cross sections are found over a broad spectral range in the near-infrared spectral region, with values up to 4100 GM in the 1400–1600 nm range and even higher values of up to 51770 GM in the 850–950 nm range, which is outstanding for organic chromophores of this molecular size. Our quantum chemical calculations support the experimental findings and elucidate the underlying absorption mechanism leading to the corresponding 2PA properties. The occurrence of such large cross sections is explained by the high oscillator strength of the first excited singlet state and its strong coupling to higher excited electronic states. The large (state-to-state) transition dipole moments originate from the acceptor–π–donor–π–acceptor structure of the parent quinoidal bithiophene motif common to all compounds, which in addition also enables their optimal (anti)parallel alignment due to its symmetry and linearity.}, archive = {J_ANGEW}, author = {Gabriel Sauter and Antonia Papapostolou and Audrey Pollien and Sergius Boschmann and Kathleen Fuchs and Pascal Merten and Kerstin Brödner and Frank Rominger and Jan Freudenberg and Uwe H. F. Bunz and Andreas Dreuw and Petra Tegeder}, doi = {10.1002/anie.202503073}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exceptionally high two-photon absorption cross sections in quinoidal diazaacene-bithiophene derivatives}, volume = {64}, year = {2025}, }
• (2025). Unusual MurC ligase and peptidoglycan discovered in lachnospiraceae using a fluorescent L-amino acid based selective labeling probe. ANGEW, 64(23), e202503049. (www)

  @article{ , abstract = {Developing selective labeling probes for specific bacterial taxa can not only facilitate the study of target bacteria but also deepen our understanding of the microbial diversity at structural and molecular levels. The availability of such probes, however, remains very limited. In this study, by exploiting the variation of amino acids in peptidoglycan stem peptide, we designed a fluorescent L-amino acid probe and found that it can selectively target the family Lachnospiraceae (a major Gram-positive family in murine gut microbiome) in vivo. The following in vitro test using two Roseburia species belonging to this family validated labeling by the probe. We then discovered that the labeling site is the first amino acid (L-alanine in most bacteria), which links the stem peptide with N -acetylmuramic acid, a process catalyzed by a highly conserved enzyme MurC. An enzyme assay of Roseburia MurC demonstrated its ability to conjugate a fluorescent L-amino acid and other non-L-Ala amino acids to UDP- N -acetylmuramic acid. Subsequent X-ray crystallography analysis uncovered a substantially enlarged inner space in this enzyme, which can partially explain its tolerance to these atypical substrates. The resulting unusual peptidoglycan structures lead to significantly reduced activation of the NOD immune receptors, suggesting a new mechanism for the host to accommodate these highly abundant commensals.}, archive = {J_ANGEW}, author = {Yahui Du and Yixia Wang and Ming Yang and Liyuan Lin and Jie Zhang and Zhi Huang and Chang Liu and Shuangjiang Liu and Jinbiao Ma and Chaoyong Yang and Wei Wang}, doi = {10.1002/anie.202503049}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202503049}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unusual MurC ligase and peptidoglycan discovered in lachnospiraceae using a fluorescent L-amino acid based selective labeling probe}, volume = {64}, year = {2025}, }
• (2025). Perovskite homojunction solar cells by buried interface engineering. ANGEW, 64(23), e202502994. (www)

  @article{ , abstract = {Constructing a strong p–n junction is an effective strategy to drive the separation of photogenerated charge carriers and boost the photovoltaic performance of solar cells. However, forming p-type and n-type semiconductors in perovskites is not as straightforward as in archetypal Si by doping electron-accepting and electron-donating elements. Here, we observe the transition of p-type to n-type characteristics in a perovskite layer via buried interface engineering. The perfluorinated copper phthalocyanine (F 16 CuPc) molecules with strong electronegativity are employed to modify the NiO x /Me-2PACz substrate, which not only facilitates the crystallization of the perovskite, but also induces the formation of p-type perovskite at its buried interface. We observe a gradual shift of the Fermi level from near valence band at the perovskite buried interface to near conduction band at the perovskite top surface, manifesting the transition from p-type to n-type within the monolithic perovskite layer. Such a p–n homojunction provides an extra electric field for accelerating charge carrier transportation, and thus enhances the device photovoltaic performance. The F 16 CuPc induced perovskite homojunction solar cells achieved a champion efficiency of 25.0% and it retained over 80% of its initial efficiency for more than 1100 h. We believe that the perovskite homojunction strategy will also pave the way for other perovskite-based optoelectronic devices.}, archive = {J_ANGEW}, author = {Manting Liu and Jinmei Xu and Haoran Yang and Zhiqiang Guan and Chunhui Zhang and Qian Li and Bo Liu and Kai Yan and Yaocheng Jin and Qing-Dan Yang and Yanping Huo and Yuanhang Cheng}, doi = {10.1002/anie.202502994}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502994}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Perovskite homojunction solar cells by buried interface engineering}, volume = {64}, year = {2025}, }
• (2025). Steric coordinated electrolytes for fast-charging and low-temperature energy-dense lithium-ion batteries. ANGEW, 64(23), e202502978. (www)

  @article{ , abstract = {Electrolytes are known as the dominant factors for fast-charging affordability and low-temperature capability of lithium-ion batteries (LIBs). Unfortunately, the current electrolytes can hardly simultaneously satisfy all the required characteristics, including sufficient ion transport, high oxidation/reduction interfacial stability, and fast de-solvation process over a wide-temperature range. Here, we report a solution by designing electrolyte solvents that coordinate with Li + in steric configuration. The steric coordinated electrolytes (SCEs) can overcome the dilemma of quasi-planer coordinated ether electrolytes that has to be weakly coordinated with Li + to avoid solvent co-intercalation towards graphite (Gr) anode, therefore enabling the merits including sufficiently dissociation of Li-salt with high ionic conductivity, low de-solvation energy, and forming electrode-electrolyte interphase with low energy barrier. As results, the SCEs with only single-salt and single-solvent (trimethoxymethane) achieve fast kinetics towards Gr anode and high oxidation stability. The LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811)||Gr LIBs can reach 80% state of the charge in 6 min, and the Ah-level energy-dense pouch cells (4.5 V) retain 82.96% (500 cycles) and 85.94% (200 cycles) of initial capacities at room temperature and −20 °C, respectively. Our work deepens the fundamental understanding of Li-ion solvation structures and affords an effective approach to design sustainable fluro-free electrolytes for battery systems.}, archive = {J_ANGEW}, author = {Xu Liu and Jingwei Zhang and Jia Li and Lianqiang Peng and Zihang Xi and Xuanyu Yun and Kun Li and Huaqing Yu and Yawen Li and Weiwei Xie and Jun Chen and Qing Zhao}, doi = {10.1002/anie.202502978}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Steric coordinated electrolytes for fast-charging and low-temperature energy-dense lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Oxygen atom migration dominates anomalous reversible oxidation of ru nanosheets. ANGEW, 64(23), e202502927. (www)

  @article{ , abstract = {Oxidation is a ubiquitous reaction in nature. For most metals (especially metal nanoparticles [NPs]), they will be completely oxidized under suitable conditions, except ruthenium (Ru). In this work, in situ transmission electron microscopy (in situ TEM) and ex situ spectroscopy were employed to investigate the oxidation process of Ru nanosheets. Ex situ spectroscopic analysis demonstrates the incomplete oxidation of Ru nanosheets to RuO₂, while the in situ TEM observations uncover an anomalous reverse phase transformation from the oxidized to metallic phase during oxidation. Combined with theoretical calculations, the oxygen atom migration dominates the reversible oxidation process, strikingly distinct from the unidirectional oxidation pathways in conventional metallic systems. The as-generated abundant Ru─RuO 2 heterointerfaces formed through reversible oxidation provide a wealth of active sites for electrochemical alkaline hydrogen evolution reaction (HER). Herein, the study not only lays a foundation for the understanding complex dynamic oxidation processes, but also offers new insights into the design of nanocatalysts.}, archive = {J_ANGEW}, author = {Xiong Xiao and Yongli Shen and Wei Xi and Lin Gu and Xiaogang Li and Baojuan Xi and Shenglin Xiong and Changhua An}, doi = {10.1002/anie.202502927}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502927}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen atom migration dominates anomalous reversible oxidation of ru nanosheets}, volume = {64}, year = {2025}, }
• (2025). Unveiling the influence of dehydrofluorination of poly(vinylidene fluoride) binder on the failure of graphite anode in potassium-ion batteries. ANGEW, 64(23), e202502872. (www)

  @article{ , abstract = {The poly(vinylidene fluoride) (PVDF) binder has been successfully employed in lithium-ion batteries (LIBs), but it unexpectedly exhibits detrimental effects on the anode performance in potassium-ion batteries (PIBs). The PVDF-based graphite electrode shows a low Coulombic efficiency and even fails to maintain the electrode integrity after several cycles in the 0.8 M KPF 6 ethylene carbonate/diethyl carbonate electrolyte. In this study, we unveil that the dehydrofluorination reaction of PVDF initiated by potassium ethoxide may be the key factor causing the above issues. The dehydrofluorination not only disables the binder but also releases detrimental ethanol into the electrolyte. The released ethanol can dissolve the organic components of solid electrolyte interphase (SEI) and deplete the potassium resource, thereby resulting in a reduction of Coulombic efficiency and a more severe accumulation of SEI. The crowding of more accumulated SEI coupled with the large volume expansion of intercalated graphite results in the failure of PVDF-based graphite electrodes. This fundamental finding may provide a deeper insight into the failure mechanism of PVDF as a binder in PIBs, and meanwhile, give valuable guidance for the use of PVDF in battery communities containing sodium-ion batteries and LIBs.}, archive = {J_ANGEW}, author = {Yangtian Yan and Junyang Hu and Yueteng Gao and Tingzheng Hou and Biao Zhang and Jin Liang and Baohua Li and Feiyu Kang and Dengyun Zhai}, doi = {10.1002/anie.202502872}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the influence of dehydrofluorination of poly(vinylidene fluoride) binder on the failure of graphite anode in potassium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Concise total syntheses of leuconoxine-type alkaloids enabled by Palladium/Norbornene-catalyzed pyrrole difunctionalization. ANGEW, 64(23), e202502736. (www)

  @article{ , abstract = {Concise total syntheses of five leuconoxine-type alkaloids, i.e., chloromelodinine, leuconodine A, leuconodine F, melodinine E, and leuconoxine, are achieved through a pyrrole-centered strategy. The approach features a newly developed palladium/norbornene-catalyzed pyrrole double C─H functionalization reaction to generate the core skeleton and a divergent oxidative dearomatization to complete the end game. In addition, no protecting group was employed, and the strategic use of a chloro substituent offers a number of advantages in these syntheses, which could have implications beyond this work. The discovery of an unusual chloro 1,2-migration reaction enabled the first total synthesis of chloromelodinine E. This work represents the shortest syntheses of these natural products to date with 10–11 total steps.}, archive = {J_ANGEW}, author = {Xin Liu and Yun Zhou and Yu Meng and Qi Zhu and Renhe Li and Guangbin Dong}, doi = {10.1002/anie.202502736}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502736}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concise total syntheses of leuconoxine-type alkaloids enabled by Palladium/Norbornene-catalyzed pyrrole difunctionalization}, volume = {64}, year = {2025}, }
• (2025). Achieving 32% efficiency in Perovskite/Silicon tandem solar cells with bidentate-anchored superwetting self-assembled molecular layers. ANGEW, 64(23), e202502730. (www)

  @article{ , abstract = {The inhomogeneity of hole-selective self-assembled molecular layers (SAMLs) often arises from the insufficient bonding between anchors and metal oxide, particularly on textured silicon surfaces when fabricating monolithic perovskite/silicon tandem solar cells (P/S-TSCs) and the hydrophobic carbazole complicates the fabrication of high-quality perovskite films. To address this, we developed a novel bidentate-anchored superwetting aromatic SAM based on an upside-down carbazole core as a hole-selective layer (HSL), denoted as ((9H-carbazole-3,6-diyl)bis(4,1-phenylene))bis(phosphonic acid) (2PhPA-CzH). The bisphosphonate-anchored exhibited enhanced adsorption capabilities and efficient hole extraction/transport, and the reversely substituted carbazole ring contributed a friendly super wetting underlayer that enabled high-quality perovskite films with minimized energetic mismatches, which 2PhPA-CzH played a pivotal role in dual interfacial energy regulation. Through these advancements, the optimized wide-bandgap (1.68 eV) PSCs demonstrated an improved PCE of 22.83% and excellent stability with T 90 exceeding 1000 h under damp-heat conditions (ISOS-D-3, 85% RH, 85 °C), representing one of the best performances for SAMs as HSL-based PSCs. Notably, 2PhPA-CzH-functionalized recombination layers extended to submicron-pyramid texture SHJ to fabricate P/S-TSCs, achieving an impressive efficiency of 32.19% at an active area of 1 cm 2 (certified 31.54%) while maintaining excellent photostability. This work offers guidance for designing multidentate-anchored SAMs to realize record PCE and excellent stability in P/S-TSCs.}, archive = {J_ANGEW}, author = {Chi Li and Yong Chen and Yuheng Li and Zhewei Zhang and Jing Yang and Yao Wang and Lijie Gong and Zhen Yuan and Lusheng Liang and Siyi Liu and Yongxin Zhu and Chongyan Lian and Mustafa Haider and Tie Guo and Xiaohua Xu and Dongdong Li and Enbing Bi and Peng Gao}, doi = {10.1002/anie.202502730}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502730}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving 32% efficiency in Perovskite/Silicon tandem solar cells with bidentate-anchored superwetting self-assembled molecular layers}, volume = {64}, year = {2025}, }
• (2025). Enantioselective spirocyclization of pd-enolates and isocyanates. ANGEW, 64(23), e202502583. (www)

  @article{ , abstract = {An enantioselective cyclization of Pd-enolates and isocyanates to form spirocyclic γ-lactams is reported. This reaction proceeds under mild reaction conditions and utilizes a novel Meldrum's acid derivative to achieve catalyst turnover, delivering enantioenriched products in up to 97% yield and 96% ee. Preliminary mechanistic investigations suggest that the reaction may proceed via the formation of higher-order species.}, archive = {J_ANGEW}, author = {Jay P. Barbor and Kaylin N. Flesch and Melinda Chan and Hannah R. Ang and Brian M. Stoltz}, doi = {10.1002/anie.202502583}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502583}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective spirocyclization of pd-enolates and isocyanates}, volume = {64}, year = {2025}, }
• (2025). Symmetry-breaking strategy yields dopant-free small molecule hole transport materials for inorganic perovskite solar cells with 20.58% efficiency and outstanding stability. ANGEW, 64(23), e202502478. (www)

  @article{ , abstract = {Inorganic perovskites are known for their excellent photothermal stability; however, the photothermal stability of all-inorganic n-i-p perovskite solar cells (PSCs) is compromised due to ion diffusion and free radical-induced degradation caused by the use of doped spiro-OMeTAD hole transport materials (HTMs). In this study, two isomeric donor–acceptor–donor (D–A–D) type small molecules, namely HBT and HiBT, were developed and used as dopant-free HTMs, using 2,1,3-benzothiadiazole or benzo[ d ][1,2,3]thiadiazole as acceptor moieties. The HiBT molecule, with its symmetry-breaking features, exhibits a large dipole moment, enhanced coordination-active sites, and a well-aligned energy level structure, all of which contribute to passivating perovskite surface defects and improving free charge separation. As a result, inorganic CsPbI 3 PSCs with HiBT HTM achieved an impressive power conversion efficiency (PCE) of 20.58%, the highest reported for dopant-free HTM-based inorganic PSCs. Moreover, the enhanced hydrophobic properties of HiBT molecules, coupled with their ability to passivate perovskite surface defects, contribute to significantly improved device stability. The unencapsulated devices based on HiBT HTM retained over 83% and 80% of their initial efficiency after being stored at 85 °C for 50 days and undergoing maximum power point (MPP) tracking at 85 °C for 1100 h, respectively. These results highlight that the symmetry-breaking strategy is an exceptionally effective approach for designing efficient, dopant-free small molecule HTMs, significantly contributing to both the high efficiency and enhanced stability of all-inorganic PSCs.}, archive = {J_ANGEW}, author = {Huimin Cai and Qiliang Zhu and Tianchen Pan and Lunbi Wu and Xin Gu and Chenghao Duan and Liangbin Xiong and Jiaying Wu and Sha Liu and Liyang Yu and Ruipeng Li and Keyou Yan and Ruijie Ma and Shengjian Liu and Tao Jia and Gang Li}, doi = {10.1002/anie.202502478}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502478}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Symmetry-breaking strategy yields dopant-free small molecule hole transport materials for inorganic perovskite solar cells with 20.58% efficiency and outstanding stability}, volume = {64}, year = {2025}, }
• (2025). Stereocontrolled phenol-yne click polymerization toward high-performance bioplastics with closed-loop recyclability. ANGEW, 64(23), e202502416. (www)

  @article{ , abstract = {Hydroxyl-yne click polymerization is a highly atom-economic and powerful tool for constructing sequence-controlled and structure-diverse unsaturated polymers. However, the cis/trans stereochemistry remains underdeveloped, thus lacking a stereodivergent synthesis of stereocontrolled polymers. Herein, we first report the organocatalyzed stereocontrolled phenol-yne click polymerization of bioderived diphenols and dipropiolates by judiciously changing the substrates, catalysts, and reaction solvents. Various sequence- and stereocontrolled poly(vinyl ether ester)s were effectively synthesized under mild reaction conditions, in which the trans content in the polymeric backbone can be proportionally altered in the range of 46%–100%. More importantly, the bulk properties of these materials such as thermal ( T d,5% of 329–362 °C; T g of 48–92 °C), mechanical (ultimate tensile strengths of 41–89 MPa, tensile moduli of 960–1991 MPa, and elongations at break of 71%–242%), and transport properties (oxygen transmission rates of 0.2–0.3 bar and water vapor transmission rates of 1.3–2.8 g mm m −2 day −1 ) can be tuned broadly. Moreover, the installed dynamic acetal moieties contribute to the excellent degradability and recyclability of these materials. This study provides an efficient and sustainable strategy for synthesizing stereoregulated biopolymers with closed-loop recyclability, thereby expanding the chemical diversity of click polymers with structure-controlled and tailored properties.}, archive = {J_ANGEW}, author = {Wei Chen and Yong-Qiang Teng and Ming-Yang Yang and Tian-Jun Yue and Wei-Min Ren and Xiao-Bing Lu and Hui Zhou}, doi = {10.1002/anie.202502416}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereocontrolled phenol-yne click polymerization toward high-performance bioplastics with closed-loop recyclability}, volume = {64}, year = {2025}, }
• (2025). Decoding variants of pyrite, arsenopyrite, and marcasite using an electron counting rule. ANGEW, 64(23), e202502322. (www)

  @article{ , abstract = {Pyrite (P), marcasite (M), and arsenopyrite (A) are of significant historical and contemporary interest. Compounds adopting these structure types are studied for their crystallographic properties and potential applications in energy storage and conversion. Despite numerous investigations since the 1970s, understanding the chemical behaviour of pyrite, marcasite, and arsenopyrite remains limited. This study proposes a new structure determining electron (SDE) rule to systematise these compounds without relying on formal charge assignments. The SDE rule predicts structure types based on the distribution of non-localised electrons around transition metals, providing a framework for identifying and categorising related compounds. We observe good agreement with literature data and furthermore synthesised nine new ternary compounds within the Pt/Ir-Ge–As/Sb systems, demonstrating the applicability of SDE. Our findings reveal that these compounds can be seen as layer configurations of P, M and A, enhancing our understanding of their chemical diversity. This work not only categorises existing compounds, but also paves the way for future exploration of new materials, highlighting the structural potential of P, M, A-related compounds beyond traditional frameworks. Preliminary results indicate that the type of layers influences physical properties, such as electrical conductivity, warranting further investigation into the relationship between structure and function in these compounds.}, archive = {J_ANGEW}, author = {Kristian Witthaut and Sandra Kreiner and Dirk Johrendt}, doi = {10.1002/anie.202502322}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502322}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoding variants of pyrite, arsenopyrite, and marcasite using an electron counting rule}, volume = {64}, year = {2025}, }
• (2025). Enhancing heterointerface coupling for durable industrial-level proton exchange membrane water electrolysis. ANGEW, 64(23), e202502250. (www)

  @article{ , abstract = {The industrial-level application of proton exchange membrane water electrolysis (PEMWE) lies in the capacity of operating at high current density in order for higher power density and lower operational cost. However, it poses a significant challenge to the overall performance of catalysts. Heterointerface engineering has emerged as an ideal strategy for addressing the anodic intrinsic activity limitations. Nevertheless, due to the fragile interface structure with weak interactions between different components, it is difficult to maintain the high activity and long-term stability of heterostructured catalysts. Herein, we report a ternary heterostructured catalyst, RuIrO x –CeO 2 , featuring a strong-coupled interface between RuIrO x phase and CeO 2 phase. This strong-coupled interface exhibits both electronic and oxygen interaction, which effectively inhibits the active phase separation. When applied in PEMWE (0.8 mg Ir cm −2 for the anode and 0.4 mg Pt cm −2 for the cathode), the resultant catalyst expresses impressive activity, achieving a current density of 3.0 A cm −2 at a cell voltage of 1.75 V in PEMWE and demonstrates a stable 2000-h operation at 5.0 A cm −2 with an imperceptible voltage degradation of <1 µV h −1 .}, archive = {J_ANGEW}, author = {Kai Sun and Wei Mao and Lujie Jin and Wenjuan Shi and Wenzhe Niu and Chenyang Wei and Yixiang He and Qisheng Yan and Ruijie Wang and Youyong Li and Bo Zhang}, doi = {10.1002/anie.202502250}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502250}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing heterointerface coupling for durable industrial-level proton exchange membrane water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Avoiding the kauzmann paradox via interface-driven divergence in states. ANGEW, 64(23), e202502197. (www)

  @article{ , abstract = {Kauzmann paradox (KP) suggests that deeply supercooled liquids can have a lower entropy than the corresponding crystalline solids. While this entropy catastrophe has been thoroughly studied via equilibrium thermodynamics, the solidification process occurs far-from-equilibrium. By analyzing this process experimentally and theoretically, we show that surface chemical speciation (oxidation-driven generation and self-organization of different species of the alloy components) in core-shell particles (CSPs) can perturb the entropy production to an extent that a continuum equilibrium phase transition is not possible. Speciation of the surface causes divergence of associated stress vectors that generate nonequilibrium fluxes and frustrates homogeneous nucleation hence deep undercooling. The asymmetry of the speciation-derived surface tensor skews the minimum entropy production criterion. We analyze a set of nonequilibrium models, one showing and one averting the entropy catastrophe. Applying thermodynamic speed limits to these models, we show that the KP takes another form. Deviations from the speed limit diverge the configurational entropy of the glass, but adding an interfacial state avoids the entropy catastrophe with significantly large supercooling.}, archive = {J_ANGEW}, author = {Andrew Martin and Jason R. Green and Martin Thuo}, doi = {10.1002/anie.202502197}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502197}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Avoiding the kauzmann paradox via interface-driven divergence in states}, volume = {64}, year = {2025}, }
• (2025). Hierarchical optical waveguides based on serpentine-like organic pseudo-plastic crystals that mimic neural networks. ANGEW, 64(23), e202502122. (www)

  @article{ , abstract = {Optical components and circuits for signal generation and processing are essential for artificial neural networks (ANNs). We present an interconnected, four-layered organic crystal optical waveguide architecture that mimics an ANN. This structure is constructed from pseudo-plastic organic crystals of (E )-1-(((5-methylpyridin-2-yl)imino)methyl)naphthalene-2-ol (MPyIN) using an atomic force microscopy (AFM) cantilever tip-based micromanipulation technique. By strategically selecting four MPyIN crystal waveguides of varying lengths, bending them into serpentine-like forms, and integrating them hierarchically, we create interconnected, neuron-like optical waveguides with six optical synapses. These synapses enable parallel transmission of passive optical signals through evanescent coupling across multiple paths within the waveguides. The feedforward mechanism allows the synapses to split the input optical signal into four diverging signals with different magnitudes. Certain outputs deliver mixed passive and active signals due to diverging and converging optical paths. This hierarchical, ANN-like architecture offers a foundation for developing smart optical neural networks using multiple emissive and phase-changing organic crystals.}, archive = {J_ANGEW}, author = {Avulu Vinod Kumar and Mehdi Rohullah and Melchi Chosenyah and Gaddam Sindhuja and Rajadurai Chandrasekar}, doi = {10.1002/anie.202502122}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502122}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hierarchical optical waveguides based on serpentine-like organic pseudo-plastic crystals that mimic neural networks}, volume = {64}, year = {2025}, }
• (2025). Revealing transition state stabilization in organocatalytic ring-opening polymerization using data science. ANGEW, 64(23), e202502090. (www)

  @article{ , abstract = {In nature, enzymes leverage constituent amino acid residues to create catalytically active sites to effect high reactivity and selectivity. Multicomponent host–guest assemblies have been exploited to mimic enzymatic microenvironments by pre-organizing a network of noncovalent interactions. While organocatalysts such as thioureas have gained widespread success in organic transformation and controlled polymerization, evaluation of the participating structural features in the transition state (TS) remains challenging. Herein, we report the use of data science tools, i.e., a decision-tree-based machine-learning algorithm and Shapley additive explanations (SHAP) analysis, to model reactivity and regioselectivity in a thiourea-catalyzed ring-opening polymerization of 1,2-dithiolanes. Variation of aryl substituent position and electronic characteristics reveals key catalyst features involved in the TS. The analysis of feature importance helps explain the reason behind the optimal performance of (pseudo)halogen-substituted catalysts. Furthermore, the structural basis for the unveiled reactivity-regioselectivity trade-off in the catalysis are established.}, archive = {J_ANGEW}, author = {Miaomiao Zhang and Yuming Su and Tianyi Du and Shihao Ding and Jieyu Dai and Cheng Wang and Yun Liu}, doi = {10.1002/anie.202502090}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202502090}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing transition state stabilization in organocatalytic ring-opening polymerization using data science}, volume = {64}, year = {2025}, }
• (2025). C─S bonds modulated nanointerface tension to create stable magnetic hollow nanocarbons for efficient microplastics capture. ANGEW, 64(23), e202501973. (www)

  @article{ , abstract = {Microplastic pollution poses significant threats to aquatic ecosystems and human health. Hollow nanomaterials are promising adsorbents for microplastics remediation due to their tailorable architectures, functions, and large contact area. Nevertheless, the structural stability of well-defined nanostructures has always been a critical factor, and understanding the stability principle is desired. Herein, we fabricated magnetic hollow nanocarbons as “nano-analytical tool”, revealing that the stability is related to additional pressure caused by nanointerface tension at curved carbon shell surface. To mitigate this, we introduced C─S bonds by sulfurizing carbon matrix, suppressing the condensation of oxygen-containing groups and thereby reducing interface tension. As a showcase, the stable hollow Fe 3 O 4 @C/S enabled rapid and efficient microplastics capture (100% within 10 s, 53 600 mg g −1 capacity) under an alternating magnetic field, owing to the magnetically accelerated mass transfer and increased contact area. Additionally, sulfur modification broadens applicability range where carbon surface is oppositely charged to microplastics, expanding the universality in capturing multiple types of microplastics, even under challenging conditions including different pH and salinities. This work offers guidance into the precise synthesis of hollow nanomaterials from nanointerface perspective. The design principles involving sulfur modification and high-contact area may open prospects for high-capacity microplastics capture in complex aquatic environments.}, archive = {J_ANGEW}, author = {Rui-Ping Zhang and Fan Wu and Wen-Cui Li and Tian-Jing Zhang and Xu Wang and Zhankai Liu and Lu Hou and An-Hui Lu}, doi = {10.1002/anie.202501973}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C─S bonds modulated nanointerface tension to create stable magnetic hollow nanocarbons for efficient microplastics capture}, volume = {64}, year = {2025}, }
• (2025). Quantum mechanical tunnelling probes with redox cycling for ultra-sensitive detection of biomolecules. ANGEW, 64(23), e202501941. (www)

  @article{ , abstract = {Quantum mechanical tunnelling sensors (QMTs) have emerged as a promising technology for next-generation single-molecule detection. Furthermore, QMT sensors can be combined with redox species resulting in repeated oxidation and reduction (redox cycling).. We developed robust QMT probes with electrode gap distances below 2 nm. Using the generator-collector (GC) mode, we verified that redox cycling of the ferrocyanide/ferricyanide (Fe(CN) 6 3−/4− ) couple occurs both in the tunnelling regime and on the electrode surface. Our findings indicated that the current enhancement is affected by both the gap distance and surface modifications of the probes. These QMT probes exhibited remarkable sensitivity, capable of detecting Fe(CN) 6 3−/4− concentrations down to sub-picomolar levels. Utilising this ability to modulate redox reactions, we adapted the QMT probes to serve as electrochemical sensors for detecting viral proteins. By modifying the electrode surfaces, our functionalised QMT probes achieved sub-pM detection limits with high selectivity in biofluids such as nasopharyngeal secretions. These findings highlight the potential of QMT probes to develop into a new class of electrochemical tunnelling sensors, offering significant advancements in biomedical diagnostics.}, archive = {J_ANGEW}, author = {Long Yi and Tao Jiang and Ren Ren and Ji Cao and Joshua B. Edel and Aleksandar P. Ivanov and Longhua Tang}, doi = {10.1002/anie.202501941}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501941}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantum mechanical tunnelling probes with redox cycling for ultra-sensitive detection of biomolecules}, volume = {64}, year = {2025}, }
• (2025). Carbon and oxygen double defects-enhanced ru-based catalyst for ammonia decomposition. ANGEW, 64(23), e202501898. (www)

  @article{ , abstract = {Although ammonia is widely recognized as one of the most promising candidates for hydrogen storage and transformation, the catalytic mechanisms involved in ammonia decomposition remain insufficiently understood, and the stability of catalysts continues to present significant challenges. In this study, Ru/CeO 2 -CNTs catalysts with double defect sites were synthesized by a straightforward method, achieving an outstanding hydrogen production rate of 2230 mmol −1 g Ru −1 min −1 at 500 °C, outperforming most Ru-based catalysts. Experimental characterization and theoretical calculations revealed that the CeO 2 -CNTs interface promotes the formation of oxygen vacancies (O v ) and carbon defects (C d ) through carbon–oxygen interactions. These defects enhance electron transfer from the support to Ru nanoparticles (NPs), modulate NH 3 adsorption and activation and modulate the recombination and desorption of adsorbed N species (N*). Moreover, the coating of CeO 2 significantly improved the stability of CNTs, which weakens undesired reactions under high-temperature and hydrogen-rich conditions. The study introduced a rational design strategy that enhances the multiple elementary stages of the NH 3 decomposition by constructing double defect sites and offering new insights into the design of efficient and durable catalysts under harsh environments.}, archive = {J_ANGEW}, author = {Likang Lv and Peiqi Chu and Tong Han and Yunpeng Jiang and Zhiwei Wang and Yuxi Liu and Hongxing Dai and Lu Wei and Jiguang Deng}, doi = {10.1002/anie.202501898}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501898}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon and oxygen double defects-enhanced ru-based catalyst for ammonia decomposition}, volume = {64}, year = {2025}, }
• (2025). Oxygen-substituted porous C2N frameworks as efficient electrocatalysts for carbon dioxide electroreduction. ANGEW, 64(23), e202501896. (www)

  @article{ , abstract = {The electrochemical carbon dioxide reduction reaction (CO 2 RR) provides a green avenue for decarbonizing the conventional chemical industries. Here, a structure–selectivity relationship of catalysts is pivotal for the control of a highly selective and active CO 2 RR pathway. We report the fabrication of an oxygen-substituted C 2 N as metal-free catalyst (O─C 2 N) for electrochemical CO 2 ─to─CO conversion with tunable O microenvironment. Combined spectroscopic analysis reveals a fine tailored N─C─O moiety in O─C 2 N, where C─O─C species (e.g., ring in-plane ether) become the dominant oxygen configurations at higher pyrolysis temperatures. Based on experimental observations, a correlation between the exocyclic O-substituted N─C─O─C moieties and CO selectivity is established, giving clear chemical tools for active structure design. The optimized O─C 2 N electrocatalysts with the dominant appearance of C─O─C moieties exhibit an outstanding 2e − CO 2 RR performance with a CO selectivity up to 94.8%, which can be well maintained in a practical flow-cell reactor with an adjustable syngas feature.}, archive = {J_ANGEW}, author = {Shuai Wang and Shujie Zhou and Zhipeng Ma and Nana Gao and Rahman Daiyan and Joshua Leverett and Yihao Shan and Xiaofeng Zhu and Yufei Zhao and Qiang Liu and Rose Amal and Xunyu Lu and Tianxi Liu and Markus Antonietti and Yinguang Chen and Qingran Zhang and Zhihong Tian}, doi = {10.1002/anie.202501896}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501896}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen-substituted porous C2N frameworks as efficient electrocatalysts for carbon dioxide electroreduction}, volume = {64}, year = {2025}, }
• (2025). Membrane-bounded intracellular e3 ubiquitin ligase-targeting chimeras (MembTACs) for targeted membrane protein degradation. ANGEW, 64(23), e202501857. (www)

  @article{ , abstract = {Targeted protein degradation (TPD) represents a potent therapeutic strategy aimed at dismantling disease-associated target proteins. PROTAC is the most widely developed technique for intracellular protein degradation, while its degradation ability on membrane proteins has been hindered by the need for complex synthetic processes and limited permeability. In this study, we developed the membrane-bounded intracellular E3 ubiquitin ligase-targeting chimeras (MembTACs) that simultaneously recruit intracellular E3 ubiquitin ligase and bind to the desired membrane proteins for targeted degradation of membrane proteins. We demonstrate that the MembTACs can effectively utilize intracellular E3 ubiquitin ligase to degrade the therapeutically relevant membrane proteins of EpCAM and Met via the proteasome pathway. We anticipate that the new platform will expand the range of PROTAC applications and provide a new dimension for targeted membrane protein degradation.}, archive = {J_ANGEW}, author = {Mengwu Mo and Feiyu Wang and Huiming Zhang and Ying Zhang and Chaoyong Yang and Jinbiao Shang and Zhi Zhu}, doi = {10.1002/anie.202501857}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501857}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Membrane-bounded intracellular e3 ubiquitin ligase-targeting chimeras (MembTACs) for targeted membrane protein degradation}, volume = {64}, year = {2025}, }
• (2025). Transition from tunneling to schottky barriers in molecular junctions based on polyoxometalate monolayers. ANGEW, 64(23), e202501763. (www)

  @article{ , abstract = {Schottky barriers are typically observed in mesoscale materials but are challenging to form at the molecular scale due to the discrete energy levels of molecules and the limited length of the transport channel, which hinder the development of an effective depletion region. In this study, we present the development of a molecular-scale Schottky diode within a monolayer junction by utilizing self-assembled monolayers (SAMs) of polyoxometalate (POM) nanoclusters. The high electron affinity and multiple redox states of POMs facilitate band bending at the molecule/EGaIn (Ga and In alloy) electrode interface, promoting the formation of a Schottky-like band structure. This molecular monolayer junction demonstrates an exceptional rectification ratio exceeding 3000, and temperature-dependent measurements reveal a transition in the charge transport mechanism from direct tunneling at low bias to thermionic emission at high bias. POM-based molecular junctions offer promising potential for molecular-scale Schottky devices, introducing novel mechanisms for high-performance molecular diodes. With their low power consumption, molecular diversity, and potential for integration into nanoscale circuits, molecular Schottky diodes are well-positioned to become key components in functional molecular devices.}, archive = {J_ANGEW}, author = {Jin-Liang Lin and Ang Zheng and Yu Xie and Ningyue Chen and Rui-Lin He and Bangchen Yin and Wenkun Lv and Yongge Wei and Yuan Li}, doi = {10.1002/anie.202501763}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501763}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transition from tunneling to schottky barriers in molecular junctions based on polyoxometalate monolayers}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic generation of a ground-state electron donor through water activation. ANGEW, 64(23), e202501757. (www)

  @article{ , abstract = {Electron donors that can be excited to higher energy states through light absorption can achieve oxidation potentials as low as −3.0 V (vs. SCE). However, ground-state organic electron transfer reagents operating at such potentials remain underdeveloped, often necessitating multi-step syntheses and elevated reaction temperatures for activation. The longer lifetime of ground-state reagents is an advantage compared to most photoexcited single-electron reductants, which typically have relatively short lifetimes. In this study, catalytically generated phosphine oxide radical anions derived from phosphines and water applying redox catalysis are introduced as highly efficient single-electron reductants. The in situ generated radical anions are capable of reducing electron-rich aryl chlorides at potentials as low as −3.3 V (vs. SCE). Cyclic voltammetry studies and DFT calculations provide valuable insights into the behavior of these phosphorus-based ground-state electron donors. These findings do not only expand the chemistry of phosphoranyl radicals but also unlock the potential of in situ generated organic ground state electron donors that reach potentials comparable to elemental potassium.}, archive = {J_ANGEW}, author = {Maxim-Aleksa Wiethoff and Lena Lezius and Armido Studer}, doi = {10.1002/anie.202501757}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501757}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic generation of a ground-state electron donor through water activation}, volume = {64}, year = {2025}, }
• (2025). Cation-anion-engineering modified oxychloride zr-based lithium superionic conductors for all-solid-state lithium batteries. ANGEW, 64(23), e202501749. (www)

  @article{ , abstract = {Within the family of halide solid electrolytes (SEs), Li 2 ZrCl 6 demonstrates high oxidative stability, cost-effectiveness, and mechanical deformability, positioning it as a promising candidate for SEs. However, the application of Li 2 ZrCl 6 as a SEs was hindered by its low ionic conductivity at room temperature. Current strategies to enhance the ionic conductivity of Li 2 ZrCl 6 primarily are focused on single cation or anion sublattice-engineering, each with distinct advantages and limitations. Here, we propose a novel cation and anion-sublattice-engineering strategy, termed CASE, to increase the amorphous content and thus enhance ionic conductivity. The incorporation of Cu 2+ and O 2− induces distinctive structural modifications within Li 2 ZrCl 6 . This structure corroborated through analytic data of X-ray absorption spectroscopy, the neutron diffraction, and ab initio molecular dynamics. Consequently, the amorphous Li 2.1 Zr 0.95 Cu 0.05 Cl 4.4 O 0.8 achieves an enhanced ionic conductivity of 2.05 mS cm −1 at 25 °C. Furthermore, all-solid-state lithium batteries utilizing the amorphous Li 2.1 Zr 0.95 Cu 0.05 Cl 4.4 O 0.8 as an electrolyte and LiNi 0.83 Co 0.11 Mn 0.06 O 2 as a cathode exhibit a superior long-term cycling stability retaining 90.3% of capacity after 1000 cycles at 2 C under room temperature, which are much higher than those of Zr-based halide electrolytes in publications. Such a result might stimulate the development of more amorphous structures with high ionic conductivity in the CASE strategy.}, archive = {J_ANGEW}, author = {Zongnan Li and Yongbiao Mu and Kunxi Lü and Guojian Kang and Ting Yang and Shuping Huang and Mingdeng Wei and Lin Zeng and Yafeng Li}, doi = {10.1002/anie.202501749}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cation-anion-engineering modified oxychloride zr-based lithium superionic conductors for all-solid-state lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Halogen-atom transfer enabled Z-selective styrene synthesis via dual cobalt and photocatalysis through coupling of unactivated alkyl iodides with terminal arylalkynes. ANGEW, 64(23), e202501630. (www)

  @article{ , abstract = {An efficient Z -selective cobalt-catalyzed reductive hydroalkylation of terminal aryl alkynes with unactivated alkyl iodides has been achieved, providing a straightforward and modular route to access 1,2-disubstituted Z -styrenes. This reaction operates under mild conditions without requiring over-stoichiometric amounts of metal terminal reductants. Excellent Z/E ratios and good to excellent yields can be achieved for diverse and complex scaffolds with remarkable functional-group compatibility. One potential utility of this reaction is demonstrated by the efficient synthesis of several syn homoallylic alcohols in a one-pot two-step sequence. Control experiments strongly support that the halogen-atom transfer (XAT) process is the key to generating carbon radicals. DFT studies suggest that the catalytic system involves the Co(II)/Co(III) cycle and the steric repulsion between the Co(II) catalyst, and the alkenyl radical in radical capture by Co(II) is the dominant factor controlling the Z/E selectivity. This approach represents the first example of merging photo-XAT with cobalt-catalyzed reductive coupling of terminal aryl alkynes with unactivated alkyl iodides.}, archive = {J_ANGEW}, author = {Anxiang Huang and Zhao Liu and Ruobin Wang and Xinran Chang and Mingxing Feng and Yuxin Xiang and Xiaotian Qi and Jun Zhu}, doi = {10.1002/anie.202501630}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501630}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogen-atom transfer enabled Z-selective styrene synthesis via dual cobalt and photocatalysis through coupling of unactivated alkyl iodides with terminal arylalkynes}, volume = {64}, year = {2025}, }
• (2025). Regiospecific 2,3-dialkylindole synthesis enabled by alkylpalladium 1,2-migration to in situ formed aldimine. ANGEW, 64(23), e202501582. (www)

  @article{ , abstract = {2,3-Dialkylindoles play crucial roles in natural products and pharmaceuticals, but the step-efficient and regioselective construction of such privileged structures remains a long-standing challenge. Here, we report a regiospecific non-Fischer indole synthesis through chemoselective 1,2-migratory addition of alkylpalladium to an aldimine intermediate, formed in situ through a palladium hydride-triggered sequential isocyanide and intramolecular olefin insertion. This unprecedented 1,2-migratory addition leads to formal C═C bond cleavage and isocyano carbon insertion between the two sp 2 carbons, offering a novel approach to specific 2,3-dialkyl substituted N─H free indoles from readily available alkyl substituted 1-isocyano-2-vinylbenzenes.}, archive = {J_ANGEW}, author = {Sidi Cheng and Yingxiang Liang and Tao Zhang and Meiling Chen and Jing Li and Xiaohan Zhang and Shuang Luo and Qiang Zhu}, doi = {10.1002/anie.202501582}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501582}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regiospecific 2,3-dialkylindole synthesis enabled by alkylpalladium 1,2-migration to in situ formed aldimine}, volume = {64}, year = {2025}, }
• (2025). In situ light-driven pH modulation for NMR studies. ANGEW, 64(23), e202501440. (www)

  @article{ , abstract = {Proton exchange is a fundamental chemical event, and NMR provides the most direct readout of protonation events with site-specific resolution. Conventional approaches require manual titration of sample pH to collect a series of NMR spectra at different pH values. This requires extensive sample handling and often results in significant sample loss, leading to reduced signal or the need to prepare additional samples. Here, we introduce a novel approach to control pH in NMR samples using water soluble photoacids, which alters the pH of the solution from near neutral to acidic pH upon in situ photo illumination. We show that the solution pH can be precisely controlled by choice of illumination wavelength and intensity, and sufficient protons are released from the photoacid to achieve meaningful pH change in samples where the molecule of interest has significant buffering capacity, such as a >100 µM protein sample. The pH is monitored in situ using internal standards with pH-sensitive chemical shifts. This method enables precise, calibrated, and noninvasive change of sample pH within an NMR magnet, dramatically reducing the necessary sample handling. These findings highlight the potential of light-induced pH control in NMR experiments and increase the robustness and reliability of pH-dependent studies.}, archive = {J_ANGEW}, author = {Aarav Barde and Ruixian Han and Martin A. Olson and Marco Tonelli and Chad M. Rienstra and Katherine A. Henzler-Wildman and Thirupathi Ravula}, doi = {10.1002/anie.202501440}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501440}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ light-driven pH modulation for NMR studies}, volume = {64}, year = {2025}, }
• (2025). Isolation of a square pyramidal bis(amidophenolate)-supported As(III)-cation: Coordination-induced electromerism at as. ANGEW, 64(23), e202501439. (www)

  @article{ , abstract = {The synthesis and structural characterization of a slightly distorted square pyramidal arsenium cation is reported. Spectroscopic, crystallographic, and computational evidence indicate that coordination of typical Lewis bases to the As(III)-center induces its oxidation to As(V) with concomitant reduction of the supporting, redox-active bis(amidophenolate) ligand. That reaction is reversible and represents a well-defined example of base-induced electromerism in an As-complex. Single electron reduction of the same As(III) species initially generates a ligand-centered radical, which is persistent enough to be observed by EPR but slowly decays to a heterodimer. Preliminary experiments demonstrate the utility of the As(III)-cation as initiator for transfer hydrogenation reactions.}, archive = {J_ANGEW}, author = {Simon B. H. Karnbrock and Jan F. Köster and Christopher Golz and Ricardo A. Mata and Manuel Alcarazo}, doi = {10.1002/anie.202501439}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501439}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isolation of a square pyramidal bis(amidophenolate)-supported As(III)-cation: Coordination-induced electromerism at as}, volume = {64}, year = {2025}, }
• (2025). Enantioselective photochemical generation of a short-lived, twisted cycloheptenone isomer: Catalytic formation, detection, and consecutive chemistry. ANGEW, 64(23), e202501433. (www)

  @article{ , abstract = {Cyclohept-2-enone-3-carboxylic acid undergoes a photochemical isomerization from its cis - to its trans -form either upon direct irradiation ( λ = 366 nm) or in the presence of a triplet sensitizer ( λ = 459 nm). The intermediate chiral trans -isomer was detected by step-scan FTIR, displaying a lifetime of 130 µs (r.t., CH 2 Cl 2 ). Ensuing Diels–Alder reactions of the trans -isomer occurred smoothly and produced chiral trans -fused cycloaddition products (14 examples, 24%–98% yield). Benzylation led to esters, which were separated by chiral HPLC and which were employed to evaluate a possible enantioselective reaction course. It was discovered that a chiral phosphoric acid with a pendant sensitizing group induces a notable enantioselectivity in the photoisomerization step. The planar chirality of the trans -cycloheptene translates into point chirality in the Diels–Alder reaction (seven examples, up to 38% ee ). Computational studies suggest that the chiral conformation of the cis -isomer adopted within the assembly to the chiral phosphoric acid induces the enantioselectivity in a one-bond flip (OBF) toward the trans -isomer. Trajectory surface hopping (TSH) simulations showed exemplarily how a chiral trans -cyclohept-2-enone is formed from a chiral cis -conformer. For the Diels–Alder reaction, a weak ground state selectivity was found to attenuate the enantioselectivity achieved in the photochemical step.}, archive = {J_ANGEW}, author = {Max Stierle and Constantin Jaschke and Daniel J. Grenda and Martin T. Peschel and Thomas Pickl and Niklas Gessner and Patrick Nuernberger and Benjamin P. Fingerhut and Christian Ochsenfeld and Regina de Vivie-Riedle and Thorsten Bach}, doi = {10.1002/anie.202501433}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501433}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective photochemical generation of a short-lived, twisted cycloheptenone isomer: Catalytic formation, detection, and consecutive chemistry}, volume = {64}, year = {2025}, }
• (2025). Dual-responsive phosphorus-based fluorescent sensors: Synthesis and selective metal sensing of pyrazolyl phosphine oxides. ANGEW, 64(23), e202501421. (www)

  @article{ , abstract = {Despite a wealth of previously reported frameworks for fluorescent metal sensors, there are few examples of phosphorus-based fluorophores being used in metal sensing applications. Here, we report the synthesis and characterization of a new family of pyrazolyl phosphine oxides and their use in metal sensing applications. The mechanism of their formation has been probed in detail with both computational and experimental studies, rationalizing the selectivity of the reaction. Their use as dual-responsive fluorescent metal sensors is then demonstrated, with “turn-off” and “turn-on” responses observed for Fe 3+ and Al 3+ , respectively. These systems exhibit good selectivity, large Stokes shifts, and submicromolar limits of detection and will open new avenues in phosphorus-based fluorophores and metal-sensing applications.}, archive = {J_ANGEW}, author = {Ethan D. E. Calder and Isobel R. J. Hawes and Andrew R. Jupp}, doi = {10.1002/anie.202501421}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501421}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-responsive phosphorus-based fluorescent sensors: Synthesis and selective metal sensing of pyrazolyl phosphine oxides}, volume = {64}, year = {2025}, }
• (2025). Microporous hard carbon support provokes exceptional performance of single atom electrocatalysts for advanced air cathodes. ANGEW, 64(23), e202501307. (www)

  @article{ , abstract = {Single atom catalysts embracing metal-nitrogen (MN x ) moieties show promising performance for oxygen reduction reaction (ORR). The modification on spatially confined microenvironments, which won copious attention with respect to achieving efficient catalysts, are auspicious but yet to be inspected for MN x moieties from modulating the energetics and kinetics of ORR. Here, Fe single atoms (SAs) are immobilized in microporous hard carbon (Fe-SAs/MPC), in which the microporous structure with crumpled graphene sheets serves confined microenvironment for catalysis. Fe-SAs/MPC holds a remarkable half-wave potential of 0.927 V and excellent stability for ORR. Theoretical studies unveil that hydrogen bonding between the intermediate of O* and micropore interior surfaces substantially promote its protonation and accelerate the overall ORR kinetics. Both the aqueous and quasi-solid-state zinc-air batteries driven by Fe-SAs/MPC air cathode show excellent stability with small charging/discharging voltage gaps. Importantly, when used as the air cathode for industrial chlor-alkali process, the applied voltage of Fe-SAs/MPC-based flow cell to reach 300 mA cm −2 is 1.57 V, which is 210 mV smaller than Pt/C-based one. These findings provide in-depth insights into the confined microenvironment of MN x moieties for boosted electrochemical performance, and pave the pathways for future catalyst development satisfying the requirement of industrial applications.}, archive = {J_ANGEW}, author = {Haijing Liu and Ping Li and Kaicai Fan and Fenghong Lu and Qi Sun and Qi Zhang and Bin Li and Yajie Shu and Lingbo Zong and Lei Wang}, doi = {10.1002/anie.202501307}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501307}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Microporous hard carbon support provokes exceptional performance of single atom electrocatalysts for advanced air cathodes}, volume = {64}, year = {2025}, }
• (2025). Antimicrobial peptide-peptoid macrocycles from the polymyxin b2 chemical space. ANGEW, 64(23), e202501299. (www)

  @article{ , abstract = {Macrocycles have emerged as important new modalities in drug discovery. In the context of addressing the global threat of antimicrobial resistance, here we used a genetic algorithm as a computational tool to evolve peptide-peptoid macrocycles to resemble polymyxin B2 ( PMB2 ), a macrocyclic lipopeptide natural product used as last resort antibiotic. Synthesis and testing of 41 PMB2 analogs revealed several peptide-peptoid macrocycles showing strong, although salt sensitive, activity against Escherichia coli and multidrug-resistant strains of Pseudomonas aeruginosa , high serum stability, and lower toxicity to kidney cells compared to PMB2 . These macrocycles resembled PMB2 in terms of outer membrane permeabilization, inner membrane depolarization, lipopolysaccharide binding, and loss of activity when linearized, but, unlike PMB2 , induced aggregation of intracellular contents, an effect was reported for other antimicrobial peptoids. These experiments exemplify a combined computational and experimental approach which might be generally useful to explore the chemical space of macrocyclic peptide natural products.}, archive = {J_ANGEW}, author = {Etienne Bonvin and Markus Orsi and Thierry Paschoud and Ashvin Gopalasingam and Jérémie Reusser and Thilo Köhler and Christian van Delden and Jean-Louis Reymond}, doi = {10.1002/anie.202501299}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501299}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antimicrobial peptide-peptoid macrocycles from the polymyxin b2 chemical space}, volume = {64}, year = {2025}, }
• (2025). Electron-deficient alkyne lipids enable efficient synthesis of comparable polymer lipids via copper-free azide-alkyne cycloaddition. ANGEW, 64(23), e202501262. (www)

  @article{ , abstract = {Polymer lipids (PLs) are essential components of liposomes and lipid nanoparticles (LNPs) for drug and gene delivery, providing colloidal stabilization and defining the biological interface. While poly(ethylene glycol) (PEG)-based PLs are the current standard, they are suspected to be responsible for rare adverse reactions, e. g. to LNP-based Covid-19 vaccines. Therefore, PLs based on alternative stealth polymers are being intensively investigated for their use in LNPs. However, alternative PLs often lack comparability due to different synthesis protocols and are often not easily accessible. Herein we present a catalyst-free, efficient and versatile coupling procedure for PL synthesis based on azide-functionalized polymers and electron-deficient acetylene dicarboxylate lipids. To highlight the versatility of this approach, we prepared PLs based on PEG and 4 alternative stealth polymers with quantitative coupling efficiencies. The linker structure showed appropriate pH stability and biocompatibility. All PLs enabled the preparation of well-defined liposomes with excellent stability. Our facile and versatile approach yields comparable PLs with minimized linker size, making them promising candidates for future comparative studies, and biomedical applications.}, archive = {J_ANGEW}, author = {Florian T. Kaps and Anna-Lena Ziegler and Paul Fritsche and Ekaterina Takmakova and Andrew Kerr and Susanne Boye and Albena Lederer and Robert Luxenhofer}, doi = {10.1002/anie.202501262}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron-deficient alkyne lipids enable efficient synthesis of comparable polymer lipids via copper-free azide-alkyne cycloaddition}, volume = {64}, year = {2025}, }
• (2025). Monitoring glycolysis by endogenous 31P CEST magnetic resonance imaging. ANGEW, 64(23), e202501189. (www)

  @article{ , abstract = {In this study, we present a novel approach to investigate glycolysis by means of the 3 ¹P CEST technique applied to phosphate-containing substrates at their endogenous concentration. The method relies on the assessment of the saturation transfer (ST) observed on the 3 ¹P signals of inorganic phosphate (Pi) or phosphocreatine (PCr) following the selective irradiation of phosphate groups of endogenous molecules exchanging with ATP, Pi, and indirectly with PCr in enzyme-catalyzed reactions. The concentrations of these substrates often fall below the threshold for direct detection. The 3 ¹P CEST technique amplifies their responses, making them detectable via the ST effect to the 3 ¹P resonance of the selected reference signal. The method was first validated in vitro on mouse breast adenocarcinoma cell pellets (TS/A), where the intracellular Pi signal was monitored to assess the ST effect associated with the saturation of phosphoester-containing molecules. The use of a glycolysis inhibitor and different experimental temperatures (37 °C or 4 °C) provided insights supporting the rationale behind the method. A comparison of 3 ¹P Z-spectra was carried out on murine breast cancer cell lines with different degrees of aggressiveness, showing the ability to assess metabolic differences. Finally, in vivo experiments on mice models of mammary adenocarcinoma demonstrated that 3 ¹P CEST can differentiate tumor and healthy tissue based on their metabolic characteristics.}, archive = {J_ANGEW}, author = {Giulia Vassallo and Cecilia Fiorucci and Francesca Garello and Silvio Aime and Daniela Delli Castelli}, doi = {10.1002/anie.202501189}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501189}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Monitoring glycolysis by endogenous 31P CEST magnetic resonance imaging}, volume = {64}, year = {2025}, }
• (2025). Competitive-coordination-induced crystallization regulation for efficient and stable Sn–Pb perovskite solar cells. ANGEW, 64(23), e202501188. (www)

  @article{ , abstract = {The unbalanced crystallization rate between Sn- and Pb-based perovskites leads to their heterogeneous distribution and inferior quality of Sn–Pb perovskite films. The promising strategy of selective molecular interaction would balance the crystallization rate. However, the deeper selectivity mechanism needs to be considered, particularly in terms of the entire coordination reaction in the perovskite precursor solution. Herein, we take advantage of thermodynamics and molecular orbital theory to reveal the competitive coordination of additive, i.e., methyl 5-aminolevulinate hydrochloride (5-AH), with SnI 2 and PbI 2 . The SnI 2 competes with PbI 2 in coordinating with 5-AH to form the thermodynamically favored SnI 2 -5-AH adducts with stronger SnI 2 -Cl − , thereby mediating the crystallization rate of the Sn- and Pb-based perovskite. Such crystallization regulation improves the composition uniformity and crystallization quality, which effectively suppresses nonradiative recombination. Additionally, the strong interaction between Sn 2+ and 5-AH as well as reductive grain boundaries inhibits the oxidation of Sn 2+ . Therefore, the optimal devices with 5-AH exhibit an improved PCE of 23.76% with a high voltage of 0.885 V and long-term stability.}, archive = {J_ANGEW}, author = {Cheng Li and Mingzhe Zhu and Shuming Zhang and Jiahui Cheng and Huijie Cao and Cheng Peng and Wenjian Yan and Chao Wang and Fang Yue and Zhongmin Zhou}, doi = {10.1002/anie.202501188}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Competitive-coordination-induced crystallization regulation for efficient and stable Sn–Pb perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Synergy between weak solvent and solid electrolyte interphase enables high-rate and temperature-resilient potassium ion batteries. ANGEW, 64(23), e202501155. (www)

  @article{ , abstract = {The rate and wide-temperature performance of graphite-based potassium-ion batteries (PIBs) are limited by slow reaction kinetics at the interphases and the solid electrolyte interphase (SEI) stability. Herein, we strategically designed weak solvating electrolytes (WSEs) to construct an efficient solvated K + desolvation with K 2 SO 3 -rich SEI and achieve fast reaction kinetics at the electrode interface through the synergy between the SEI and the WSE. As a result of the beneficial fast reaction kinetics and stability of the electrode interface, the graphite anode shows high levels of rate performance and cycling stability, with a capacity of 249.6 mAh g −1 at 500 mA g −1 and 96.6% capacity retention after 1600 cycles. Moreover, assembled potassiated graphite (KC 8 )||Prussian blue nanoparticles (K-PBNPs) cells in our designed electrolyte show high-rate performance (63.1 mAh g −1 at 1500 mA g −1 ) and over wide operating temperature range (>99% Coulombic efficiency for over 1000 cycles and 200 cycles at −20°C and 80°C, respectively). Impressively, the pouch cell shows long-term stability for 2400 cycles at 500 mAg −1 . This work bridges a longstanding gap, elucidating the synergy between the SEI components and WSEs, leading to fast-charging and temperature-resilient PIBs.}, archive = {J_ANGEW}, author = {Jie Wen and Hongwei Fu and Caitian Gao and Jiang Zhou and Apparao M. Rao and Shuangchun Wen and Bingan Lu}, doi = {10.1002/anie.202501155}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202501155}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergy between weak solvent and solid electrolyte interphase enables high-rate and temperature-resilient potassium ion batteries}, volume = {64}, year = {2025}, }
• (2025). Carbon-extraction-triggered phase engineering of rhodium nanomaterials for efficient electrocatalytic nitrate reduction reaction. ANGEW, 64(23), e202500985. (www)

  @article{ , abstract = {Phase engineering plays a crucial role in tuning the physicochemical properties of noble metal nanomaterials. However, synthesis of high-purity unconventional-phase noble metal nanomaterials remains highly challenging via current wet-chemical methods. Herein, we develop a unique synthetic methodology to prepare freestanding unconventional hexagonal close-packed (2H) Rh nanoplates (NPLs) via a rationally designed two-step strategy. By extracting C from pre-synthesized rhodium carbide of different sizes and morphology, phase-controlled synthesis of Rh nanomaterials can be achieved. Impressively, the obtained parallelogram 2H Rh NPLs have high phase purity, well-defined 2H (0001) h and (10 0) h facets, and good thermostability (stable up to 300 °C). In the proof-of-concept electrocatalytic nitrate reduction reaction (NO 3 RR), the 2H Rh NPLs achieve higher ammonia (NH 3 ) Faradaic efficiency (91.9%) and NH 3 yield rate (156.97 mg h −1 mg cat −1 ) with lower overpotentials compared to the conventional face-centered cubic (3C) Rh nanocubes with (100) f facets. Density functional theory calculations reveal that the unconventional (0001) h surface has energetically favored NO 3 RR pathway and stronger H * absorption ability compared to the (100) f surface, which may lead to the higher activity and selectivity of NH 3 production on 2H Rh NPLs. This work opens new avenues to the rational synthesis of unconventional-phase metal nanomaterials and provides important guidelines to design high-performance electrocatalysts.}, archive = {J_ANGEW}, author = {Long Zheng and Yan Zhang and Weiwei Chen and Xiangou Xu and Ruiqi Zhang and Xiao Ren and Xiaozhi Liu and Wenbin Wang and Junlei Qi and Gang Wang and Chen Ma and Lei Xu and Peng Han and Qiyuan He and Ding Ma and Jinlan Wang and Chongyi Ling and Dong Su and Minhua Shao and Ye Chen}, doi = {10.1002/anie.202500985}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202500985}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon-extraction-triggered phase engineering of rhodium nanomaterials for efficient electrocatalytic nitrate reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Aqueous self-assembly of cylindrical and tapered bottlebrush block copolymers. ANGEW, 64(23), e202500771. (www)

  @article{ , abstract = {The self-assembly of amphiphilic bottlebrush block copolymers (BCPs), featuring backbones densely grafted with two types of side chains, is less well understood compared to linear BCPs. In particular, the solution self-assembly of tapered bottlebrush BCPs—cone-shaped BCPs with hydrophilic or hydrophobic tips—remains unexplored. This study investigates eight tapered and four cylindrical bottlebrush BCPs with varied ratios of hydrophobic polystyrene (PS) and hydrophilic poly(acrylic acid) (PAA) side chains, synthesized via sequential addition of macromonomers using ring-opening metathesis polymerization (SAM-ROMP). Self-assembled nanostructures formed in water were analyzed using cryogenic transmission electron microscopy, small-angle neutron scattering, and dynamic light scattering. Most BCPs generated multiple nanostructures with surface protrusions, including spherical micelles, cylindrical micelles, and vesicles, alongside transitional forms like ellipsoids and semi-vesicles. Coarse-grained molecular dynamics simulations supported the experimental findings, which revealed two distinct self-assembly pathways. The first involved micelle fusion, producing elliptical and cylindrical aggregates, sometimes forming Y-junctions. The second pathway featured micelle maturation into semivesicles, which developed into vesicles or large compound vesicles. This work provides the first experimental evidence of vesicle formation via semivesicles in bottlebrush BCPs and demonstrates the significant influence of cone directionality on self-assembly behavior in these cone-shaped polymeric amphiphiles.}, archive = {J_ANGEW}, author = {Clark Vu and Narjess Abu Amara and Mohammed Alaboalirat and Einat Nativ-Roth and Ran Zalk and Wellington Leite and Jan-Michael Carrillo and Ronit Bitton and John B. Matson}, doi = {10.1002/anie.202500771}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202500771}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aqueous self-assembly of cylindrical and tapered bottlebrush block copolymers}, volume = {64}, year = {2025}, }
• (2025). Interfacial lithium cations catalyze biomimetic aerobic oxygenation via short-range electrostatic interaction. ANGEW, 64(23), e202500546. (www)

  @article{ , abstract = {Enzymes often involve short-range electrostatic interactions in the deliberate microenvironment for accelerating the catalysis. Comparatively, electrostatic interactions from ions in solutions are mostly shielded by solvent or counter-ion shells, creating negligible catalytic effects. Herein, we discovered that the interfacial Li + cations accumulated on electrodes catalyze the selective water-involved O 2 electro-reduction into peroxide anion (OOH − ), forming an active side-on Li + –OOH − complex via short-range electrostatic interaction. This complex reduces the O 2 reduction energy barrier and increases the nucleophilicity, expediting the aerobic oxygenation of ketones. Aside from trapping active intermediates, Li + cations also attract the excessive water dipoles to prevent them from quenching the active Li + –OOH − complex. By using probe-assisted quantitative methods, we demonstrated the unique under-coordinative characteristics of interfacial Li + for interacting with reaction intermediates, and the effective concentration of under-coordinative Li + on the interface is an order of magnitude higher than in the bulk solution. These analyses provide essential evidences about the intrinsic difference between bulk ions and interfacial ions toward catalysis.}, archive = {J_ANGEW}, author = {Shuangshuang Cha and Yizhou Yang and Wei Du and Tao Jiang and Ran Wang and Mengxin Qu and Zhe Ji and Chang Yan and Xuejing Yang and Ming Gong}, doi = {10.1002/anie.202500546}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202500546}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial lithium cations catalyze biomimetic aerobic oxygenation via short-range electrostatic interaction}, volume = {64}, year = {2025}, }
• (2025). Asymmetric synthesis of noradamantane scaffolds via diphenylprolinol silyl ether-mediated domino Michael/Epimerization/Michael (or aldol)/1,2-addition reactions. ANGEW, 64(23), e202500378. (www)

  @article{ , abstract = {Topologically unique chiral noradamantanes are synthesized using a diphenylprolinol silyl ether-mediated domino Michael/epimerization/Michael/1,2-addition or Michael/epimerization/aldol/1,2-addition reaction with excellent enantioselectivity in a single reaction vessel. Three carbon–carbon bonds are formed, and six chiral centers, including one all-carbon quaternary center, are generated, five of which are fully controlled. These functionalized noradamantanes are 3D, cage-like molecules that can serve as valuable chiral building blocks for drug design.}, archive = {J_ANGEW}, author = {Konstantinos Daskalakis and Nariyoshi Umekubo and Satrajit Indu and Genki Kawauchi and Tohru Taniguchi and Kenji Monde and Yujiro Hayashi}, doi = {10.1002/anie.202500378}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202500378}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric synthesis of noradamantane scaffolds via diphenylprolinol silyl ether-mediated domino Michael/Epimerization/Michael (or aldol)/1,2-addition reactions}, volume = {64}, year = {2025}, }
• (2025). Achieving spectral narrowing by strengthening the soliton-like characteristics through peripheral group substitution in aromatic heterocyclic emitters. ANGEW, 64(23), e202500235. (www)

  @article{ , abstract = {The effect of substituents on the spectral behavior of aromatic heterocyclic systems is a significant yet highly complex issue. Inspired by cyanine dyes, it was found that emission spectrum narrowing can be realized by regulating the terminal substituents to enhance the soliton-like characteristics of emitters. Herein, compared to the parent compound 2AcPh (full-width at half-maximum, FWHM = 0.124 eV), the introduction of fluorobenzene-group substituents in 2AcPh-PhF narrows the emission spectral FWHM to 0.108 eV. Single crystal structures reveal more homogeneous carbon–carbon bond lengths in 2AcPh-PhF compared to 2AcPh. Theoretical calculations show that the charge magnitudes on carbon atoms of 2AcPh-PhF also become homogenized, but the charges on adjacent carbon atoms are opposite. These results suggest that the soliton-like electronic structural characteristics in 2AcPh-PhF are enhanced after introducing peripheral substituents, which is considered to be the reason for the narrower emission spectrum of 2AcPh-PhF. The sky-blue organic light-emitting diode devices based on 2AcPh-PhF demonstrated a maximum external quantum efficiency of 29.17% and a small electroluminescent spectral FWHM of 25 nm.}, archive = {J_ANGEW}, author = {Wenle Tan and Yue Yu and Yulong Li and Hanlin Gan and Lei Xu and Mingke Li and Bohan Wang and Lingyu Wang and Xinyu Wang and Lei Ying and Yuguang Ma}, doi = {10.1002/anie.202500235}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202500235}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving spectral narrowing by strengthening the soliton-like characteristics through peripheral group substitution in aromatic heterocyclic emitters}, volume = {64}, year = {2025}, }
• (2025). Efficient circularly polarized luminescence from Mn–Br hybrid perovskite assembled by achiral architectures. ANGEW, 64(23), e202425543. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL)-active materials have attracted considerable attention due to their potential applications in various advanced technological fields. CPL activity typically requires compounds that crystallize in noncentrosymmetric chiral space groups. Achieving noncentrosymmetric crystal structures using achiral molecular architectures is highly appealing but remains a significant challenge. Herein, we present a strategy for designing and synthesizing high-performance CPL materials via crystallization-driven self-assembly using achiral architectures. We successfully obtained Mn 2+ -based halide enantiomeric hybrids ( P - 1 and M - 1 ), self-assembled from [MnBr 4 ] 2− anions and rotational symmetric [Pr-dabco] 2+ cations (Pr-dabco 2+ = 1-propyl-1,4-diazabicyclo-[2.2.2]octan-1-ium), crystallizing in the chiral space group P 2 1 2 1 2 1 . The single crystals of 1 exhibit exceptionally high CPL performance, with a luminescence dissymmetry factor | g lum | and photoluminescence quantum yield (PLQY) up to 4.8 × 10 −2 and 86.8%, respectively, thus a record-high figure of merit (FM) of 4.2 × 10 −2 among reported Mn 2+ -based CPL materials. Furthermore, P / M - 1 based UV-LED devices demonstrated outstanding light-emitting performance, including high color-purity, excellent stability, remarkable luminous brightness (74 591.94 cd m −2 ), and a high electroluminescence dissymmetry factor ( g lum ) value of 3.2 × 10 −2 . This study offers a robust strategy for the design and development of high-performance CPL materials utilizing achiral molecular architectures.}, archive = {J_ANGEW}, author = {Lu Zhai and Jiayi Yuan and Jianyi Huang and Xue-Wei Pan and Li Wan and Weihua Ning and Xiao-Ming Ren}, doi = {10.1002/anie.202425543}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202425543}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient circularly polarized luminescence from Mn–Br hybrid perovskite assembled by achiral architectures}, volume = {64}, year = {2025}, }
• (2025). Hydrogen binding energy is insufficient for describing hydrogen evolution on single-atom catalysts. ANGEW, 64(23), e202425402. (www)

  @article{ , abstract = {The design principles for metal–nitrogen–carbon (M-N-C) single-atom catalysts (SACs) in the hydrogen evolution reaction (HER) have been extensively studied. Yet, consensus remains elusive, hindering advancements in hydrogen energy technologies. Although the hydrogen binding energy (Δ G H* ) has long been used as a key HER descriptor during the past two decades, originating from the activity volcano of metallic surfaces, its applicability to HER SACs has been met with significant controversy. Herein, we investigate the effects of HO*/O* poisoning and H* coverage on SACs with varied metal centers and coordination environments using pH-dependent surface Pourbaix diagrams at the reversible hydrogen electrode (RHE) scale and microkinetic modeling. Our findings reveal that HO* poisoning, realistic H* adsorption strengths at active metal sites, and the potential HER activity at the coordinating N-sites are crucial factors that should be considered for accurate descriptor development. Experimental validation using a series of M-phthalocyanine/CNT catalysts (M = Co, Ni, Cu) confirms the theoretical predictions, with excellent agreement in exchange current densities and the role of N-sites in Ni/Cu-phthalocyanine/CNT catalysts. This work provides answers to a long-lasting debate on HER descriptors by establishing Δ G H* and Δ G HO* as a combined HER descriptor for SACs, offering new guidelines for catalyst design.}, archive = {J_ANGEW}, author = {Songbo Ye and Fangzhou Liu and Fangxin She and Jiaxiang Chen and Di Zhang and Akichika Kumatani and Hitoshi Shiku and Li Wei and Hao Li}, doi = {10.1002/anie.202425402}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202425402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen binding energy is insufficient for describing hydrogen evolution on single-atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Activating interfacial ion exchange in composite electrolytes to realize high-rate and long-cycling solid-state lithium batteries. ANGEW, 64(23), e202425221. (www)

  @article{ , abstract = {Composite solid electrolytes (CSEs) are promising candidates for solid-state lithium metal batteries. However, the poor cross-phase Li + transport restricts the rate performance and cycle life of the batteries. Herein, we revealed the Li + percolation behavior in poly(vinylidene fluoride) (PVDF)-based CSEs with Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 filler. The de-coordination barrier from Li + clusters determines interfacial Li + transport capability. We then employed a designed N -methyl-2,2,2-trifluoroacetamide (NMTFA) ligand to lower the de-coordination energy and activate interfacial Li + exchange. The ionic conductivity is therefore increased from 3.32 × 10 −4 to 7.30 × 10 −4 S cm −1 . By tracking the 6 Li and 7 Li substitution process, it was identified that the proportion of interfacial Li + transport increases from 11% to 26%. The NMTFA also contributes to the formation of inorganic-rich interphases with electrodes. As a result, the Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 solid-state batteries exhibit ultra-long lifespans of 2400, 3000, and 10 000 times at 2, 5, and 10C, respectively, as well as achieve 1000 cycles at 50 °C and 300 cycles at −30 °C. This work highlights the critical role of interfacial Li + transport for the CSEs with “polymer-Li + clusters-filler” configuration to realize high-rate and long-cycling solid-state lithium batteries.}, archive = {J_ANGEW}, author = {Qiannan Zhu and Ke Yang and Likun Chen and Xufei An and Shaoke Guo and Yuhang Li and Yuetao Ma and Yidan Cao and Ming Liu and Yan-Bing He}, doi = {10.1002/anie.202425221}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202425221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activating interfacial ion exchange in composite electrolytes to realize high-rate and long-cycling solid-state lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Develop complex photocatalytic system of D-π-A-type conjugated porous polymers and benzyl alcohol mediated autocatalysis for practical artificial photosynthesis of H2O2. ANGEW, 64(23), e202425017. (www)

  @article{ , abstract = {Artificial photosynthesis of H 2 O 2 is conceived to be an ideal approach for replacing the industrial anthraquinone method that suffers from hefty energy penalties and environmental toxicity. However, the low concentration of H 2 O 2 resides as the biggest hurdle for industrial production. Herein, with a focus on fabricating high-performance heterogeneous photocatalysts and establishing a highly efficient complex photocatalytic system, we report the preparation of D-π-A-type conjugated porous polymers containing a photosensitizer and redox-active anthraquinone moiety for endowing highly efficient H 2 O 2 production up to 3.0 mmol g −1 h −1 . Further, by exploiting the autocatalytic photooxidation feature of benzyl alcohol, •OOH as the key species contributing to H 2 O 2 formation received a substantial accumulation, which stems from the collaboration of the photocatalytic and autocatalytic cycle. Mechanistically, the hydrogen bonding and π–π stacking between the photocatalyst and benzyl alcohol are formed to lower the free energy of the transition states, thus leading to unprecedentedly high efficiency in the photosynthesis of H 2 O 2 up to 140.4 mmol g −1 h −1 , with the concentration of 35.1 mmol L −1 and an apparent quantum yield of 49%. This work provides critical insights in advancing sustainable energy conversion research.}, archive = {J_ANGEW}, author = {Danfeng Wang and Feiyang Tan and Wuzi Zhao and Shiyuan Zhou and Qingfeng Xu and Lixuan Kan and Lei Zhu and Peiyang Gu and Jianmei Lu}, doi = {10.1002/anie.202425017}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202425017}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Develop complex photocatalytic system of D-π-A-type conjugated porous polymers and benzyl alcohol mediated autocatalysis for practical artificial photosynthesis of H2O2}, volume = {64}, year = {2025}, }
• (2025). Synergistic solvent and composition engineering of perovskites for tandems on industrial silicon. ANGEW, 64(23), e202424809. (www)

  @article{ , abstract = {Wide-bandgap perovskites based on mixed formamidinium−cesium cation and iodide−bromide halide are promising materials in the top cells that are well-matched with crystalline silicon bottom cells to construct efficient tandem photovoltaics. Nevertheless, mixed cation−halide perovskite films with submicron film thickness suffer from poor crystallinity with inhomogeneous and undesirable phases, owing to the presence of multiple pathways of crystal nucleation and phase transition. Herein, we propose a synergistic solvent and composition engineering (SSCE) strategy to regulate the solvated phases and manipulate the transition pathways simultaneously. The resultant mixed cation−halide perovskite film shows optimizing crystallization and desired phase structure with suppressed nonradiative recombination and improved phase stability under aging stresses. Consequently, the SSCE strategy enables the tandem cells based on industrially ultrathin silicon wafers (120 µm) to achieve a certified stabilized power conversion efficiency of 31.0%. Those encapsulated devices maintain 90% of their initial performance after 1200 h continuous operation.}, archive = {J_ANGEW}, author = {Zhiliang Liu and Yang Tian and Jun Chen and Mengsha Cao and Zhibang Shen and Shaofei Yang and Ke Fan and Xi Chen and Jia Yao and Zhijun Xiong and Yu Chen and Jun Fang and Longbin Qiu and Zhong'an Li and Hong Zhang and Alex K.-Y. Jen and Kai Yao}, doi = {10.1002/anie.202424809}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424809}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic solvent and composition engineering of perovskites for tandems on industrial silicon}, volume = {64}, year = {2025}, }
• (2025). Ba–Ni–Ge clathrate transformation maximizes active site utilization of nickel for enhanced oxygen evolution performance. ANGEW, 64(23), e202424743. (www)

  @article{ , abstract = {Discovering novel oxygen evolution reaction (OER) (pre)catalysts with exceptional catalytic activity and long-term stability is pivotal for advancing decarbonization technologies. In this study, we present the ternary Ba 8 Ni 6 Ge 40 phase with an open clathrate structure exhibiting remarkable performance in alkaline OER. When integrated into an alkaline water electrolyzer, this clathrate precatalyst achieves high stability under a sustained current density of ∼550 mA cm −2 for 10 days. By combining in situ Raman spectroscopy, quasi in situ X-ray absorption spectroscopy, and (micro)structural characterizations, we elucidate the complete electrochemical transformation of Ba 8 Ni 6 Ge 40 (~90 weight% leaching) forming ultrathin nanosheets composed of a porous and defective NiOOH nanostructure with maximized accessible active site exposure. Notably, a reversible phase transition mainly between Ni(OH) 2 and NiOOH has also been established in the electrochemical redox process. Meanwhile, the successful application of the model Ba 8 Ni 6 Ge 40 precatalyst represents a promising new class of functional inorganic materials for water electrolysis.}, archive = {J_ANGEW}, author = {Ziliang Chen and Hongyuan Yang and J. Niklas Hausmann and Stefan Mebs and Viktor Hlukhyy and Holger Dau and Matthias Driess and Prashanth W. Menezes}, doi = {10.1002/anie.202424743}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424743}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ba–Ni–Ge clathrate transformation maximizes active site utilization of nickel for enhanced oxygen evolution performance}, volume = {64}, year = {2025}, }
• (2025). Regioselective nickel-catalyzed hydroarylation of gem-difluoroalkenes for the synthesis of the ArCF2− moiety. ANGEW, 64(23), e202424714. (www)

  @article{ , abstract = {The incorporation of fluorine and fluorinated functional groups into organic molecules alters their physicochemical properties, thereby facilitating the advancement of novel therapeutics, agricultural chemicals, biological probes, and materials. Nevertheless, there remains a deficiency of methodologies for the catalytic synthesis of certain significant fluorine-containing groups, such as , under mild conditions utilizing earth-abundant metals. Herein, we report a method for the regioselective hydroarylation of gem -difluoroalkenes under mild conditions with the aid of Ni─H intermediate catalysis, which is capable of efficiently synthesizing compounds containing the structural motifs and possesses good functional group tolerance.}, archive = {J_ANGEW}, author = {Xiangyu Chen and Yaxing Wu and Ruitong Zhang and Fei Wang and Chao Chen}, doi = {10.1002/anie.202424714}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424714}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioselective nickel-catalyzed hydroarylation of gem-difluoroalkenes for the synthesis of the ArCF2− moiety}, volume = {64}, year = {2025}, }
• (2025). Enhancing the stability of aqueous membrane-free flow batteries: Insights into interphase processes. ANGEW, 64(23), e202424650. (www)

  @article{ , abstract = {Membrane-free flow batteries using immiscible electrolytes aim to overcome limitations of conventional redox flow batteries by eliminating expensive ion-selective membranes. However, they face challenges including low power density due to the transport constraints in immiscible electrolytes, the need for high partitioned stable compatible active species, and the overlooked self-discharge interphase phenomena that reduce coulombic efficiency. We present a novel aqueous biphasic system based on two salts improving electrolyte ionic conductivity and viscosity. Potassium ferrocyanide (K 4 [Fe(CN) 6 ]) and a sulfonated viologen ((SPr 2 )V) species were examined computationally and experimentally, demonstrating effective redox pair separation in all oxidation states, achieving a tenfold higher concentration in their electrolyte. The mutual compatibility and stability of these species enabled unprecedented scanning electrochemical microscopy (SECM) analysis of the liquid-liquid interphase, revealing insights like species concentration gradients and crossover. The enhanced electrolyte properties expanded the open-circuit voltage to 1.1 V and improved mass transport, enabling power densities that are 3.5 times higher than previous examples. The battery achieved 80.2% energy efficiency at a C/2 rate, and under flowing conditions, it maintained stable performance over a month (400 cycles) at high states of charge. This work presents an innovative aqueous membrane-free flow battery that avoids parasitic reactions, enabling detailed interphase studies and advancing this technology.}, archive = {J_ANGEW}, author = {Paula Navalpotro and Carla Santana Santos and Murilo L. Alcantara and Vanesa Muñoz-Perales and Santiago E. Ibañez and Antonio Martínez-Bejarano and Nomnotho Jiyane and Catarina M. S. S. Neves and Rubén Rubio-Presa and Thomas Quast and Wolfgang Schuhmann and João A. P. Coutinho and Rebeca Marcilla}, doi = {10.1002/anie.202424650}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424650}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing the stability of aqueous membrane-free flow batteries: Insights into interphase processes}, volume = {64}, year = {2025}, }
• (2025). Electrolyte chemistry development for sodium-based batteries: A blueprint from lithium or a step toward originality?. ANGEW, 64(23), e202424543. (www)

  @article{ , abstract = {Currently, electrolyte design for sodium-based batteries is largely inherited from their lithium-based counterparts, which often present critical challenges that hinder forging new perspectives and thus further improvements. This work delves into the key properties of representative sodium- and lithium-based electrolytes, encompassing prevailing salt anions. It aims to evaluate the impact of cation chemistry, including their nature and the degree of interactions with counter anions, thereby bridging the gap in effectively transferring the know-how accumulated in lithium batteries to sodium-based batteries. The results demonstrate that the unique impact of salt anions on the properties of metal-ion conducting electrolytes is tightly correlated with the nature of metal cations. By synchronizing the anionic structures with the critical features of sodium cations, the solvating dynamics and transport properties, chemical stability, aluminum corrosion behavior, and other key properties of the electrolytes could be finely tuned to fit the specific requirements of advanced sodium-based batteries. This work gives an in-depth insight into the chemical and physical features of sodium-based electrolytes, with a potential avenue to accelerate the deployment of high-performance sodium batteries and simultaneously inspire and guide the design of other electrolytes for emerging mono- and multivalent cation-based rechargeable batteries.}, archive = {J_ANGEW}, author = {Ziyu Song and Zhirong Xing and Jiaxun Yang and Jiayi Chen and Weican Hu and Pu Li and Wenfang Feng and Gebrekidan Gebresilassie Eshetu and Egbert Figgemeier and Stefano Passerini and Michel Armand and Zhibin Zhou and Heng Zhang}, doi = {10.1002/anie.202424543}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424543}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte chemistry development for sodium-based batteries: A blueprint from lithium or a step toward originality?}, volume = {64}, year = {2025}, }
• (2025). Aminomethyl phosphonic acid as highly effective multifunctional additive for modification of electron transport layer and perovskite in photovoltaic solar cells. ANGEW, 64(23), e202424479. (www)

  @article{ , abstract = {The passivation of detrimental perovskite-based defects is critically acknowledged for fabricating highly effective perovskite solar cells (PSCs). The presence of a high-quality electron transport layer (ETL) is also considered a pivotal factor for effective charge extraction and transport dynamics. Herein, a simple small organic molecule, aminomethyl phosphonic acid (AMPA), is introduced as a multifunctional additive in the SnO 2 ETL. The defects in the SnO 2 ETL are effectively suppressed by passivating the oxygen vacancies upon the SnO 2 surface. Simultaneously, the carrier mobility and crystallinity of SnO 2 are enhanced, and the upward-regulated conduction band minimum (CBM) is beneficial for constructing a favorable energy level alignment with the perovskite layer. Notably, the introduced residuals on the SnO 2 surface can function as crystalline seeds for growth of large perovskite grains, which can passivate the defects in the perovskite bulk phase, boundaries, as well as the SnO 2 /perovskite interface. Consequently, the power conversion efficiency ( PCE ) value of the AMPA-modified PSCs is enhanced from 19.91% to 24.22%. Most importantly, the unencapsulated PSCs with AMPA maintained 94.9% of the initial PCE during 720 h of storage at a relative humidity of 10%, attributed to the improved hydrophobicity of both the SnO 2 and perovskite layers after AMPA modification.}, archive = {J_ANGEW}, author = {Yujie Gao and Wenyu Gong and Zeqi Zhang and Jianing Guo and Jingyuan Ma and Xuan Li and Yanli Zeng and Mingxing Wu}, doi = {10.1002/anie.202424479}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424479}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aminomethyl phosphonic acid as highly effective multifunctional additive for modification of electron transport layer and perovskite in photovoltaic solar cells}, volume = {64}, year = {2025}, }
• (2025). Synergistic effects of interfacial chemistry and ion-solvent interactions to enable reversible magnesium metal anode in chloride-free Mg(TFSI)2 electrolytes. ANGEW, 64(23), e202424237. (www)

  @article{ , abstract = {Passivation of magnesium (Mg) anode in the chloride-free magnesium bis(trifluoromethanesulfonyl)imide (Mg(TFSI) 2 ) electrolyte is a key challenge for Mg metal batteries. Tailoring solvation structure and solid electrolyte interphase (SEI) has been considered an effective strategy. Herein, a series of imidazole co-solvents with different branched-chain structures (methyl, ethyl, and propyl) are introduced into the Mg(TFSI) 2 -ether electrolyte to address the passivation issue. The ion-solvent interaction, interfacial adsorption effect, and SEI formation are comprehensively studied by theoretical calculations and experimental characterizations. Through molecular structure analysis, the long-chain 1-propylimidazole (PrIm) exhibits a strong coordination ability to Mg 2+ and a favorable parallel adsorption configuration on the Mg surface. As a result, PrIm co-solvent can not only restructure the solvation sheath of Mg 2+ , but also act as a dynamic protective shield to repel a part of TFSI − and 1,2-dimethoxyethane (DME) away from the Mg surface. Benefiting from the synergistic regulation effect of interfacial chemistry and ion-solvent interactions, the chloride-free Mg(TFSI) 2 -DME + PrIm electrolyte ensures minimal interface passivation and achieves highly reversible Mg plating/stripping. This work provides a guiding strategy for solvation structure regulation and interface engineering for rechargeable Mg metal batteries.}, archive = {J_ANGEW}, author = {Aoqi Yang and Xiang Gao and Maojun Pei and Jiacong Zhou and Honggang Wang and Can Liao and Jianhua Xiao and Yao Liu and Wei Yan and Jiujun Zhang}, doi = {10.1002/anie.202424237}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424237}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic effects of interfacial chemistry and ion-solvent interactions to enable reversible magnesium metal anode in chloride-free Mg(TFSI)2 electrolytes}, volume = {64}, year = {2025}, }
• (2025). Cooperative supramolecular polymerization in both polar and non-polar solvents via heteroatom-driven amphiphilicity. ANGEW, 64(23), e202424138. (www)

  @article{ , abstract = {Supramolecular polymers in water and non-polar solvents are extensively studied as model systems to mimic biological processes and as functional materials, respectively. The molecular designs to obtain supramolecular polymers in non-polar and polar solvents are typically orthogonal. Here, we disclose a molecular design in which we combine hydrogen-bonding amide units attached to alkyl chains for compatibility with non-polar solvents and heteroatom in the π-conjugated core for interaction with polar solvents, leading to supramolecular polymerization of the same monomeric unit in both non-polar and mixture of polar solvents. Redox-active phenazine appended with two amide groups was studied as a model monomeric unit and it undergoes cooperative polymerization via intermolecular hydrogen-bonding resulting in one-dimensional (1D) nanostructures with co-facial type packing in non-polar solvents. Whereas, in a mixture of polar solvents, a J -type packing was observed with tunable morphology from globular to 1D nanostructures based on the polarity of the cosolvent used. Further, solvent isotopic substitution studies suggest that the amphiphilicity of the system can be attributed to the nitrogen-atom in phenazine, which is capable of interacting with polar solvent molecules. Thus, this study opens up azaacenes as a new class of π-conjugated units for functional supramolecular polymers.}, archive = {J_ANGEW}, author = {Sourav Nandi and Satyabrata Behera and Chidambar Kulkarni}, doi = {10.1002/anie.202424138}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202424138}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative supramolecular polymerization in both polar and non-polar solvents via heteroatom-driven amphiphilicity}, volume = {64}, year = {2025}, }
• (2025). Plastics of the future? an interdisciplinary review on biobased and biodegradable polymers: Progress in chemistry, societal views, and environmental implications. ANGEW, 64(23), e202423406. (www)

  @article{ , abstract = {Global demand to reduce polymer waste and microplastics pollution has increased in recent years, prompting further research, development, and wider use of biodegradable and biobased polymers (BBPs). BBPs have emerged as promising alternatives to conventional plastics, with the potential to mitigate the environmental burdens of persistent plastic waste. We provide an updated perspective on their impact, five years after our last article, featuring several recent advances, particularly in exploring broader variety of feedstock, applying novel chemical modifications, and developing new functionalities. Life-cycle assessments reveal that environmental performance of BBPs depends on several factors including feedstock selection, production efficiency, and end-of-life management. Furthermore, the introduction of BBPs in several everyday life products has also influenced consumer perception, market dynamics, and regulatory frameworks. Although offering environmental advantages in specific applications, BBPs also raise concerns regarding their biodegradability under varying environmental conditions, potential microplastic generation, and soil health impacts. We highlight the need for a circular approach considering the entire polymer life cycle, from feedstock sourcing, modification and use, to end-of-life options. Interdisciplinary research, collaborative initiatives, and informed policymaking are crucial to unlocking the full potential of BBPs and exploiting their contribution to create a circular economy and more sustainable future.}, archive = {J_ANGEW}, author = {Sara T. R. Velasquez and Qisong Hu and Johanna Kramm and Vitória C. Santin and Carolin Völker and Frederik R. Wurm}, doi = {10.1002/anie.202423406}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202423406}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Plastics of the future? an interdisciplinary review on biobased and biodegradable polymers: Progress in chemistry, societal views, and environmental implications}, volume = {64}, year = {2025}, }
• (2025). High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages. ANGEW, 64(23), e202422459. (www)

  @article{ , abstract = {Cargo-filled protein cages are powerful tools in biotechnology with demonstrated potential as catalytic nanoreactors and vehicles for targeted drug delivery. While endogenous biomolecules can be packaged into protein cages during their expression and self-assembly inside cells, synthetic cargo molecules are typically incompatible with live cells and must be packaged in vitro. Here, we report a fusion-based in vitro assembly method for packaging diverse synthetic cargo into encapsulin protein cages that outperforms standard in cellulo assembly, producing cages with superior uniformity and thermal stability. Fluorescent dyes, proteins and cytotoxic drug molecules can all be selectively packaged with high efficiency via a peptide-mediated targeting process. The exceptional fidelity and broad compatibility of our in vitro assembly platform enables generalisable access to cargo-filled protein cages that host novel synthetic functionality for diverse biotechnological applications.}, archive = {J_ANGEW}, author = {Taylor N. Szyszka and Rezwan Siddiquee and Alex Loustau and Lachlan S. R. Adamson and Claire Rennie and Tiancheng Huang and Reginald Young and Andrew Care and Yu Heng Lau}, doi = {10.1002/anie.202422459}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202422459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages}, volume = {64}, year = {2025}, }
• (2025). Tailored 3-alkoxy-N,N,N,2,2-pentamethylpropan-1-ammonium Bis(trifluoromethylsulfonyl)Imide ionic liquids for room-temperature fluoride-ion batteries. ANGEW, 64(23), e202422299. (www)

  @article{ , abstract = {Two novel liquid electrolytes for room-temperature fluoride ion batteries are presented. These electrolytes are based on ionic liquids with quaternary ammonium cations 3-methoxy- N , N , N ,2,2-pentamethylpropan-1-aminium (MNPA) and N , N , N ,2,2-pentamethyl-3-(2,2,2-trifluoroethoxy)propane-1-aminium (NPPA) combined with a bis (trifluoromethylsulfonyl)-imide (TFSI) counterion. Quaternary ammonium fluorides can be added at concentrations up to 0.7 M to a functional fluoride electrolyte with a total diffusivity of 4.99 × 10 −12 m 2 s −1 , a viscosity of 260 mP⋅s and a wide operational voltage range exceeding 5.4 V. The liquid ion electrolyte with the MNPA cation supports stable fluoride ion shuttling for up to 100 h.}, archive = {J_ANGEW}, author = {Tiancheng Tan and Richard Murdey and Shunsuke Sumitomo and Kazuyuki Sato and Takeshi Abe and Atsushi Wakamiya}, doi = {10.1002/anie.202422299}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202422299}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailored 3-alkoxy-N,N,N,2,2-pentamethylpropan-1-ammonium Bis(trifluoromethylsulfonyl)Imide ionic liquids for room-temperature fluoride-ion batteries}, volume = {64}, year = {2025}, }
• (2025). From sequence definition to structure-property relationships in discrete synthetic macromolecules: Insights from molecular modeling. ANGEW, 64(23), e202420179. (www)

  @article{ , abstract = {Inspired by the exquisite properties emerging from the sequence order in nucleic acids and proteins, researchers are increasingly considering synthetic sequence-defined macromolecules (SDMs) to reach precise functions, e.g. for catalysis, data storage, energy, and health. Although researchers develop iterative techniques permitting the synthesis of perfectly defined sequences, there is still an important gap to achieve the desired properties leading to their utilization as materials. This arises from the fact that the effect of the sequence order on the 3D structure is unknown for most current synthetic SDMs. Although the Protein Data Bank gathers hundreds of thousands of elucidated 3D structures of proteins, and many more computed (using, e.g., AlphaFold), extended information on sequence-structure relationships does not exist yet for synthetic SDMs. To tackle this problem for relatively flexible synthetic macromolecules, one can nowadays utilize the existing tools of molecular modeling simulations. In this review, we report an advanced practice to reveal the 3D structures and the interactions, through the combination of all-atom molecular dynamics simulations and network analysis applied to different types of SDMs. By combining the computational results to the experimental ones, we show the potential of this approach for an in-depth understanding of the sequence-structure-property relationships in discrete macromolecular systems, toward guiding their rational design for specific functions.}, archive = {J_ANGEW}, author = {David Dellemme and Sinan Kardas and Corentin Tonneaux and Julien Lernould and Mathieu Fossépré and Mathieu Surin}, doi = {10.1002/anie.202420179}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202420179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From sequence definition to structure-property relationships in discrete synthetic macromolecules: Insights from molecular modeling}, volume = {64}, year = {2025}, }
• (2025). Introducing the aziridination of fluorinated olefins by metal-catalyzed nitrene transfer. ANGEW, 64(23), e202419188. (www)

  @article{ , abstract = {After decades of development of the metal-catalyzed nitrene transfer reactions to olefins, examples involving the use of fluorinated olefins is yet unknown, despite the current importance of fluorocompounds. Herein we describe the use of copper- and silver-based catalysts for a general protocol that converts α- or β-fluoro olefins into the corresponding aziridines in high yields.}, archive = {J_ANGEW}, author = {Jorge Pérez-Ruíz and Antonio Rosales Martínez and M. Mar Díaz-Requejo and Pedro J. Pérez}, doi = {10.1002/anie.202419188}, journal = {Angewandte Chemie International Edition}, month = {6}, number = {23}, pages = {e202419188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Introducing the aziridination of fluorinated olefins by metal-catalyzed nitrene transfer}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Photoinduced electron transfer across phospholipid bilayers in anaerobic and aerobic atmospheres. ANGEW, 64(22), e202582201. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582201}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202582201}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Photoinduced electron transfer across phospholipid bilayers in anaerobic and aerobic atmospheres}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Direct observation of cyclo-pentazolate anion decomposition in a tailored molecular trap (Angew. chem. int. ed. 22/2025). ANGEW, 64(22), e202510027. (www)

  @article{ , archive = {J_ANGEW}, author = {Jinjin Zhang and Mingjie Tang and Siyuan Yang and Hongqing Li and Guangbin Cheng and Yongxing Tang and Ming Liu}, doi = {10.1002/anie.202510027}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202510027}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Direct observation of cyclo-pentazolate anion decomposition in a tailored molecular trap (Angew. chem. int. ed. 22/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: First encapsulation of organometallic single-molecule magnet into single-walled carbon nanotubes (Angew. chem. int. ed. 22/2025). ANGEW, 64(22), e202510024. (www)

  @article{ , archive = {J_ANGEW}, author = {Haitao Zhang and Ryo Nakanishi and Takefumi Yoshida and Masahiko Nishijima and Koji Harano and Yoji Horii and Masahiro Yamashita}, doi = {10.1002/anie.202510024}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202510024}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: First encapsulation of organometallic single-molecule magnet into single-walled carbon nanotubes (Angew. chem. int. ed. 22/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Enzyme-activated orthogonal proteolysis chimeras for tumor microenvironment-responsive immunomodulation (Angew. chem. int. ed. 22/2025). ANGEW, 64(22), e202510013. (www)

  @article{ , archive = {J_ANGEW}, author = {Caixia Sun and Songhan Liu and Jun Wei Lau and Hanyu Yang and Yun Chen and Bengang Xing}, doi = {10.1002/anie.202510013}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202510013}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Enzyme-activated orthogonal proteolysis chimeras for tumor microenvironment-responsive immunomodulation (Angew. chem. int. ed. 22/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Photoredox autocatalysis: Towards a library of generally applicable reductive photocatalysts (Angew. chem. int. ed. 22/2025). ANGEW, 64(22), e202509841. (www)

  @article{ , archive = {J_ANGEW}, author = {Jaspreet Kaur and Mark John P. Mandigma and Nakul Abhay Bapat and Joshua P. Barham}, doi = {10.1002/anie.202509841}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202509841}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Photoredox autocatalysis: Towards a library of generally applicable reductive photocatalysts (Angew. chem. int. ed. 22/2025)}, volume = {64}, year = {2025}, }
• (2025). Thirupathi ravula. ANGEW, 64(22), e202507462. (www)

  @article{ , archive = {J_ANGEW}, author = {Thirupathi Ravula}, doi = {10.1002/anie.202507462}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202507462}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thirupathi ravula}, volume = {64}, year = {2025}, }
• (2025). Dandan gao. ANGEW, 64(22), e202507344. (www)

  @article{ , archive = {J_ANGEW}, author = {Dandan Gao}, doi = {10.1002/anie.202507344}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202507344}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dandan gao}, volume = {64}, year = {2025}, }
• (2025). Auxiliary ligand-coordinated nanoconfined hydrophobic microenvironments in Nickel(II)–Acetylide framework for enhanced CO2 photoreduction. ANGEW, 64(22), e202505883. (www)

  @article{ , abstract = {Metal–acetylide frameworks (MAFs), featuring metal-bis(acetylide) linkages (─C≡C─M─C≡C─), are emerging as a new class of 2D nanomaterials with promise in catalysis. Here, we report a new 2D Ni II –acetylide framework, TPA-Ni(PR 3 ) 2 -GYs, that incorporates the Ni II (PR 3 ) 2 moiety [R = CH 3 (Me), CH 2 CH 3 (Et), and CH 2 CH 2 CH 2 CH 3 (Bu)] into tris(4-ethynylphenyl)amine-based graphdiyne framework (TPA-GDY). As a result, TPA-Ni(PBu 3 ) 2 -GY exhibits an exceptional photocatalytic CO 2 reduction activity of 3807 µmol g −1 h −1 and a high selectivity of 99.4% for CO production upon visible light irradiation. Mechanistic investigations reveal a strong orbital matching effect between the d orbitals of Ni II and the p orbitals of the alkynyl C atoms in organic ligands, which not only accelerates the transfer and separation of photogenerated charge carriers but also reduces the reaction potential barrier for the formation of *COOH intermediates. Furthermore, the high hydrophobicity of the auxiliary coordinated ligands (trialkylphosphines) to Ni center, particularly tributylphosphine, creates a nanoconfined space that enhances both the accessibility of CO 2 and the utilization of Ni II catalytic active sites while inhibiting hydrogen evolution. This study highlights the benefit of modulating the microenvironment around the coordinated metal center to enhance the performance of catalysts with direct metal–acetylide bonding.}, archive = {J_ANGEW}, author = {Yingying Qin and Jian Lu and Chen Zhang and Linli Xu and Wai-Yeung Wong}, doi = {10.1002/anie.202505883}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505883}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Auxiliary ligand-coordinated nanoconfined hydrophobic microenvironments in Nickel(II)–Acetylide framework for enhanced CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Unraveling the cause of strong metal-support interaction formation: Disparities in metal nanoparticle anchoring mechanisms. ANGEW, 64(22), e202505820. (www)

  @article{ , abstract = {Strong metal-support interaction (SMSI) can be normally induced by the surface free energy differences between metal nanoparticles and supports. To gain deeper insights into the effect of SMSI on heterogeneous catalysis, we use prototype Pt, Pd/TiO 2 (anatase) systems to demonstrate different reverse water gas shift (RWGS) reaction activity changes, especially with increasing the metal nanoparticle (NP) loading. Our experiments show that the conventional surface-free-energy change law regarding the incremental NP size is no longer applicable to these systems due to the overlook of the change of support properties owing to the disparities of the metal anchoring mechanisms. Both experimental measurements and density functional theory (DFT) calculations show that Pt atoms strongly favor anchoring on the oxygen vacancies (O v ) over the OH-sites on the anatase TiO 2 support. In contrast, Pd atoms lack such O v -site preference compared to Pt atoms, thereby leaving higher content of O v on the support than the Pt counterpart. Moreover, high density of residual O v on the support can cause the Pd NPs to be in higher degree of contact with the support, either in NP-encapsulation state (experiment) or NP-spreading state (simulation). The enhanced CO 2 conversion of Pt/TiO 2 A is attributed to the synergistic effect of O v and hydrogen spillover from Pt sites.}, archive = {J_ANGEW}, author = {Yuxuan Xie and Xiongyi Liang and Zhao Li and Biao Zhou and Ping Ning and Xin Sun and Kai Li and Ken-ichi Shimizu and Xiao Cheng Zeng and Fei Wang}, doi = {10.1002/anie.202505820}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505820}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the cause of strong metal-support interaction formation: Disparities in metal nanoparticle anchoring mechanisms}, volume = {64}, year = {2025}, }
• (2025). Exploring secondary electrostatic interactions using molecular rotors: Implications for SN2 reactions. ANGEW, 64(22), e202505483. (www)

  @article{ , abstract = {Benzylic and allylic electrophiles are well known to react faster in S N 2 reactions than aliphatic electrophiles, but the origins of this enhanced reactivity are still being debated. Galabov, Wu, and Allen recently proposed that electrostatic interactions in the transition state between the nucleophile (Nu) and the sp 2 carbon (C2) adjacent to the electrophilic carbon (C1) play a key role. To test this secondary electrostatic hypothesis, molecular rotors were designed that form similar through-space electrostatic interactions with C2 in their bond rotation transition states without forming bonds to C1. This largely eliminates the alternative explanation of stabilizing conjugation effects between C1 and C2 in the transition state. The rotor barriers were strongly correlated with the experimentally measured S N 2 free energy. Notably, rotors where C2 was sp 2 or sp-hybridized had barriers that were consistently 0.5–2.0 kcal mol −1 lower than those for rotors where C2 was sp 3 -hybridized. Computational studies of atomic charges were consistent with the formation of stabilizing secondary electrostatic interactions. Further confirmation came from observing the benzylic effect in rotors where the first atom was varied, including oxygen, sulfur, nitrogen, and sp 2 -carbon. In summary, these studies provided strong experimental support for the role of secondary electrostatic interactions in the S N 2 reaction.}, archive = {J_ANGEW}, author = {Binzhou Lin and Hao Liu and Xiaolong Huang and Harrison M. Scott and Perry J. Pellechia and Ken D. Shimizu}, doi = {10.1002/anie.202505483}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505483}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploring secondary electrostatic interactions using molecular rotors: Implications for SN2 reactions}, volume = {64}, year = {2025}, }
• (2025). Metalized porphyrin-based COFs for conductive porous layers in perovskite solar cells to enhance electron injection, defect passivation, and lead-protection. ANGEW, 64(22), e202505470. (www)

  @article{ , abstract = {In perovskite solar cells (PSCs), the introduction of an intermediate layer to bridge the transport and photoactive layers has become a key strategy for enhancing carrier extraction efficiency. However, traditional approaches are often limited by the seesaw effect, making it challenging to achieve an optimal balance between electron transport and defect passivation. In this study, we employed a Cu 2+ -loaded metalized porphyrin-based covalent organic framework (Cu-Por-COF) as a conductive porous layer (CPL) at the perovskite bottom interface. Experimental results showed that a Cu-Por-COF coverage of 19% significantly enhanced electron transport and effectively suppressed long-distance electron diffusion. Moreover, the carefully designed Cu-Por-COF provided abundant active sites, which improved the film-forming quality of the perovskite layer, thereby facilitating the beneficial synergy of electron injection and defect passivation. The n-i-p type devices achieved a power conversion efficiency (PCE) of 25.41% (0.09 cm 2 ) and 21.99% (1.01 cm 2 ). Using Cu-Por-COF to stabilize the perovskite crystal structure, the unencapsulated devices retained over 81% of its initial efficiency after 2000 h. Additionally, Cu-Por-COF effectively chelated lead ions and thus enhanced the environmental sustainability of PSCs.}, archive = {J_ANGEW}, author = {Zhengyan He and Tianxiang Luan and Qilin Wei and Liang Wang and Dan Huang and Haibo Chen and Ivan Yu Dmitriev and Peizhou Li and Shufang Zhang and William W. Yu}, doi = {10.1002/anie.202505470}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505470}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metalized porphyrin-based COFs for conductive porous layers in perovskite solar cells to enhance electron injection, defect passivation, and lead-protection}, volume = {64}, year = {2025}, }
• (2025). Cascaded metalation of two-dimensional covalent organic frameworks for boosting electrochemical CO reduction. ANGEW, 64(22), e202505461. (www)

  @article{ , abstract = {The electrochemical CO reduction reaction (CORR) to high-value methanol requires the delicate design of catalysts due to the large overpotential. Especially, achieving precise modification of electrocatalysts while preserving the periodic alignment of active sites to optimize performance remains a significant challenge. Here, we report the cascaded metalation of phthalocyanine-based COFs for selective reduction of CO to methanol. After implanting the secondary metal (Ni), CityU-35 achieves a Faradaic efficiency (FE) of 48.4% at −0.85 V versus RHE, significantly surpassing that of CityU-34 (2.1%) with only Co atoms. Enhanced methanol production originates from the optimization of electronic structure with improved * CO adsorption, as substantiated by the in situ attenuated total reflectance surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS). Theoretical calculations have demonstrated that the cascaded metalation with the introduction of secondary Ni sites not only strengthens * CO adsorption but also accelerates proton generation for the hydrogenation of *CO toward CH 3 OH. The cascaded metalation with synergistic effects between Co and Ni sites reduces the energy barriers and improves the overall electroactivity. Our results demonstrate cascaded metalation as an effective strategy to tailor the catalytic activities of 2D COFs, extending the functional design of reticular frameworks in electrocatalysis.}, archive = {J_ANGEW}, author = {Qianfeng Gu and Yinger Xin and Mingzi Sun and Hexiang Zhang and Anchun Tang and Yanwei Zhao and Zihao Chen and Yun Song and Tuoya Naren and Lei Zhang and Jinghang Wu and Xin Wang and Fangyuan Kang and Yang Yang Li and Fu-Rong Chen and Chubin Wan and Bolong Huang and Ruquan Ye and Qichun Zhang}, doi = {10.1002/anie.202505461}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cascaded metalation of two-dimensional covalent organic frameworks for boosting electrochemical CO reduction}, volume = {64}, year = {2025}, }
• (2025). Correction to “An advanced 3D crosslinked conductive binder for silicon anodes: Leveraging glycerol chemistry for superior lithium-ion battery performance”. ANGEW, 64(22), e202505357. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202505357}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “An advanced 3D crosslinked conductive binder for silicon anodes: Leveraging glycerol chemistry for superior lithium-ion battery performance”}, volume = {64}, year = {2025}, }
• (2025). One-component ionizable amphiphilic janus dendrimers for targeted mRNA delivery. ANGEW, 64(22), e202505304. (www)

  @article{ , abstract = {mRNA nanomedicine represents a new generation of therapeutics. However, how to deliver mRNA to the desired organs and cells effectively remains challenging. Common mRNA delivery vectors include viral and nonviral types such as four-component lipid nanoparticles (LNPs), polymer-based nanoparticles, lipid-polymer hybrid nanoparticles, and so on. One-component ionizable amphiphilic Janus dendrimers (IAJDs), are an emerging type of mRNA delivery vehicle displaying good stability and high delivery efficiency. In this review, we comprehensively present the design, synthesis, and mRNA delivery properties of IAJDs, with particular focus on the relationship between their molecular structures and organ targeted delivery properties. Other representative types of dendrimers for RNA delivery are also reviewed. Overall, this review summarizes the recent research progress on IAJDs systematically, aiming to guide the development of more efficient mRNA delivery platforms and next-generation mRNA nanomedicines.}, archive = {J_ANGEW}, author = {Pengyu Zhu and Yongsheng Li and Dapeng Zhang}, doi = {10.1002/anie.202505304}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505304}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-component ionizable amphiphilic janus dendrimers for targeted mRNA delivery}, volume = {64}, year = {2025}, }
• (2025). Controlled deformation mode and amplitude of liquid crystal actuators through orthogonal light and heat-induced exchanges. ANGEW, 64(22), e202505172. (www)

  @article{ , abstract = {Liquid crystal elastomers (LCEs) are versatile soft actuators known for their flexible texture, low density, and ability to undergo reversible deformations that mimic the behavior of skeletal muscles. These properties make them highly attractive for applications in exoskeletons, soft robotics, and medical devices. However, their functionality is typically limited to simple and discontinuous deformations. This study introduces a novel structural design that enables precise control of both the mode and amplitude of deformation. This design integrates photo-reactive o -nitrobenzyl moieties and temperature-dependent hydrogen bonds into the LCE structure. The o -nitrobenzyl moieties enable irreversible reconfiguration of the LCE crosslinked network through photoreactions, allowing for easy alignment and reshaping of the material. Meanwhile, the hydrogen bonds act as “temperature-dependent locks”, regulating the mobility of polymer chains during thermal deformation. By adjusting the heating temperature, the deformation amplitude can be finely tuned across a wide range (0%–103%). The synergy of these two mechanisms—light-induced irreversible reconfiguration and temperature-induced reversible H-bond exchanges—empowers LCEs to achieve customizable and continuous deformations. This represents a significant advancement in bridging the gap between synthetic actuators and biological motion systems.}, archive = {J_ANGEW}, author = {Jian Ding and Tuan Liu and Jinwen Zhang and Yuzhan Li and Xuepei Miao and Caicai Li and Wanqi Chen and Baihang Chen and Xinyi Huang and Liangdong Zhang and Kun Wang and Zhixiang Dong and Bingkun Bao and Linyong Zhu and Qiuning Lin}, doi = {10.1002/anie.202505172}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505172}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled deformation mode and amplitude of liquid crystal actuators through orthogonal light and heat-induced exchanges}, volume = {64}, year = {2025}, }
• (2025). Brønsted acid-catalyzed atroposelective coupling of carboxylic acids with amines and alcohols via ynamide mediation. ANGEW, 64(22), e202505167. (www)

  @article{ , abstract = {Carboxylic acids are readily available chemicals with broad applications in chemistry-related areas, and their coupling with amines and alcohols is a fundamental transformation in organic synthesis. However, the catalytic enantioselective coupling of carboxylic acids remains elusive, especially for the atroposelective reaction. Here we report a chiral Brønsted acid (CBA)-catalyzed atroposelective coupling of carboxylic acids with amines and alcohols using ynamides as coupling reagents. The novel enantiocontrol involving CBA-catalyzed ester addition enables the straightforward construction of axially chiral amides and planar-chiral esters with high enantioselectivities through atroposelective intermolecular amidation and intramolecular macrolactonization. Diverse medicinally relevant carboxylic acids can undergo direct late-stage modification by this method. Importantly, this reaction represents the first atroposelective coupling of carboxylic acids with amines, as well as the first chemocatalytic atroposelective coupling of carboxylic acids with alcohols. The resulting atropisomeric skeletons can be readily derivatized to chiral ligands and catalysts for asymmetric catalysis.}, archive = {J_ANGEW}, author = {Hua-Hong Chen and Jia-Tian Jiang and Ye-Nan Yang and Long-Wu Ye and Bo Zhou}, doi = {10.1002/anie.202505167}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505167}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Brønsted acid-catalyzed atroposelective coupling of carboxylic acids with amines and alcohols via ynamide mediation}, volume = {64}, year = {2025}, }
• (2025). Phosphorus-doped single atom copper catalyst as a redox mediator in the cathodic reduction of quinazolinones. ANGEW, 64(22), e202505085. (www)

  @article{ , abstract = {The use of clean electric energy to activate inert compounds has garnered significant attention. Homogeneous redox mediators (RMs) in organic electrosynthesis are effective platforms for this purpose. However, understanding the RM's electronic structure under operational conditions, electron transport processes at the electrode surface, and substrate adsorption-desorption dynamics remains challenging. Here, we synthesized a Cu single-atom catalyst (SAC, named Cu─N─P@NC) with a CuN 3 P 1 micro-coordination structure, employing it as a unique cathode redox mediator. Introducing phosphine atoms into the coordination system allowed modulation of the SAC's electronic metal-support interaction, optimizing catalyst-substrate adsorption-desorption dynamics and accelerating electrochemical reactions. Utilizing the heterogeneous SAC strategy, we achieved a novel electro-reduction coupling ring-opening reaction of inert quinazolinone frameworks. The Cu-SAC exhibited exceptionally high catalytic activity and substrate compatibility, operating smoothly at gram-scale production. Additionally, we applied the SAC to modify 11 natural product molecules. Integrating micro-coordination environment regulation and theoretical adsorption models elucidated the significant influence of electrode-RMs-substrate interactions on reaction kinetics and catalytic efficiency-a feat challenging for homogeneous RMs. This approach offers a novel pathway for advancing efficient organic electrosynthesis reactions and provides critical insights for mechanistic studies.}, archive = {J_ANGEW}, author = {Xin-Yu Wang and Wan-Jie Wei and Si-Yu Zhou and Yong-Zhou Pan and Jiarui Yang and Tao Gan and Zechao Zhuang and Wen-Hao Li and Xia Zhang and Ying-Ming Pan and Hai-Tao Tang and Dingsheng Wang}, doi = {10.1002/anie.202505085}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phosphorus-doped single atom copper catalyst as a redox mediator in the cathodic reduction of quinazolinones}, volume = {64}, year = {2025}, }
• (2025). Direct access to functional 2-Azabicyclo[2.1.1]Hexanes via hydrodearomative [2π + 2σ] cycloaddition of aza-arenes. ANGEW, 64(22), e202505060. (www)

  @article{ , abstract = {Converting planar six-membered aza -arenes into C(sp 3 )-rich three-dimensional (3D) scaffolds is a promising way to obtain isosteric mimetics of numerous functional products, but it remains to date a formidable challenge due to the high thermodynamic stability and dynamic inertness as well as the selectivity control. Here, by applying a novel non-noble bimetallic Mn/Fe catalyst system, we report, for the first time, an approach for direct construction of functional 3D 2-azabicyclo[2.1.1]hexanes via a hydrodearomatization (HDA) of the aza -arenes and [2π + 2σ] cycloaddition cascade. Mechanistic investigations reveal that the triplet state of Fe(II) facilitates the activation of both aza -arenes and bicyclo[1.1.0]butanes (BCBs). The mild reduction nature of manganese catalysis and the steric effects of Fe(II) coordination result in an 1,4-hydrodearomatization, and the imine species derived from the isomerization of 1,4-hydrogenated aza -arenes are then effectively trapped by the polarized BCBs, thus suppressing the thermodynamically favorable over-hydrogenation of aza -arenes into cyclic amine by-products. Given the features of good substrate and functionality compatibility, high step and atom efficiency, and diversified product post-transformations, the developed chemistry offers a practical platform to access various functional molecules.}, archive = {J_ANGEW}, author = {Jian Yang and Bo-Xuan Yao and Huan-Feng Jiang and Shao-Fei Ni and Pierre H. Dixneuf and Min Zhang}, doi = {10.1002/anie.202505060}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505060}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct access to functional 2-Azabicyclo[2.1.1]Hexanes via hydrodearomative [2π + 2σ] cycloaddition of aza-arenes}, volume = {64}, year = {2025}, }
• (2025). Cross-linking profiling of molecular glue degrader-induced e3 ligase interactome to expand target space. ANGEW, 64(22), e202505053. (www)

  @article{ , abstract = {Molecular glue (MG) degraders, small molecules with significant therapeutic potential for targeting undruggable proteins, are emerging as new modality in drug discovery. Profiling the E3 ligase interactome induced by MG degraders provides insights into their mechanism of action and identifies clinically relevant neosubstrates for degradation, thereby offering new therapeutic opportunities. However, established methods face significant challenges in comprehensive and accurate profiling of MG degrader-induced E3 ligase interactome. Herein, we introduce the concept of globally cross-linking profiling of the MG degrader-induced E3 ligase interactome in living cells, achieved by integrating genetic code expansion technology with mass spectrometry-based proteomics. Our approach presents an efficient and robust strategy for identifying neosubstrates recruited to cereblon E3 ligase by the known degraders CC-885 and DKY709, offering valuable insights for clinical evaluation and significantly expanding their target space. Moreover, we developed two novel MG degraders with potent antiproliferative effects on cancer cells, and application of our method identified neosubstrates, revealing a previously unrecognized target landscape and advancing our understanding of E3 ligase–neosubstrate interactions. Overall, our study provides a powerful tool for neosubstrate identification and expanding target space of E3 ligase, opening new opportunities for developing next-generation MG degraders to address the clinical challenge of undruggable targets.}, archive = {J_ANGEW}, author = {Yali Xu and Wensi Zhao and Hui-Jun Nie and Jiamin Wang and Jingjing Fu and Hao Hu and Zihao Liu and Shengna Tao and Mingya Zhang and Yubo Zhou and Jia Li and Minjia Tan and Xiao-Hua Chen}, doi = {10.1002/anie.202505053}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202505053}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cross-linking profiling of molecular glue degrader-induced e3 ligase interactome to expand target space}, volume = {64}, year = {2025}, }
• (2025). Construction of local-ion trap in phase-reversed mixed matrix COF membranes for ultrahigh ion selectivity. ANGEW, 64(22), e202504990. (www)

  @article{ , abstract = {Artificial molecular/ion traps afford grand potential in membrane-based separation processes. However, the existing trap-based architectures often confer over-strong binding forces, which severely impede the release of bound solutes during their transmembrane diffusion processes. Herein, we propose an unprecedented local-ion trap bearing moderate binding force and additional repulsion force in a type of phase-reversed mixed matrix covalent organic framework (PRCOF) membrane. By implementing COF as a continuous phase and polymer as a dispersed phase at the molecular level, the local-ion trap is formed in the COF channels equipped with free amino groups from polyethyleneimine (PEI). This unique local-ion trap built by electronegative COF nano-domains and electropositive PEI nano-domains offers appropriate interaction toward Li + , which allows the precise recognition and rapid transport of Li + in the membrane channels. By tuning the microenvironments of local-ion trap, the optimum PRCOF-1 membrane exhibits considerably high actual selectivity of 190 along with a rapid Li + permeation rate of 0.262 mol h −1 m −2 in dealing with a Li + /Mg 2+ binary mixture. This work provides in-depth insights into the design of high-performance membranes with appropriate chemical interactions.}, archive = {J_ANGEW}, author = {Meidi Wang and Tian-Yu Ma and Zhuo-Hao Wu and Yawei Liu and Shuang Li and Zixuan Cheng and Xue-Qian Wu and Bojing Sun and Zhongyi Jiang and Dong-Sheng Li}, doi = {10.1002/anie.202504990}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504990}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of local-ion trap in phase-reversed mixed matrix COF membranes for ultrahigh ion selectivity}, volume = {64}, year = {2025}, }
• (2025). Built-in electric field in freestanding Hydroxide/Sulfide heterostructures for industrially relevant oxygen evolution. ANGEW, 64(22), e202504972. (www)

  @article{ , abstract = {Alkaline water electrolysis (AWE), as a premier technology to massively produce green hydrogen, hinges on outstanding oxygen evolution reaction (OER) electrodes with high activity and robust stability under high current densities. However, it is often challenged by issues such as catalytic layer shedding, ion dissolution, and inefficient bubble desorption. Herein, a scalable corrosion-electrodeposition method is presented to synthesize nickel–iron layered double hydroxide (NiFe-LDH)/Ni 3 S 2 heterostructures on nickel mesh, tailored to meet the stringent requirements of industrial AWE. The study underscores the critical role of the built-in electric field (BEF) in optimizing electronic properties, curtailing Fe leaching, and enhancing mass transfer. The resultant NiFe-LDH/Ni 3 S 2 heterostructure manifests remarkable OER performance, with ultra-low overpotentials of 202 mV at 10 mA cm −2 and 290 mV at 800 mA cm −2 in 1.0 m KOH at 25 °C, alongside superior steady-state stability and resistance to reverse current under fluctuating conditions. Furthermore, the performance is further validated in an alkaline electrolyzer, achieving a large current density of 800 mA cm −2 at a cell voltage of 1.908 V, while maintaining excellent stability. This work offers a blueprint for the design of efficient OER electrodes for industrially relevant AWE applications.}, archive = {J_ANGEW}, author = {Wentong Wu and Yueshuai Wang and Shizhen Song and Zhichao Ge and Chunyang Zhang and Jie Huang and Guiren Xu and Ning Wang and Yue Lu and Zhanfeng Deng and Haohong Duan and Maochang Liu and Cheng Tang}, doi = {10.1002/anie.202504972}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504972}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Built-in electric field in freestanding Hydroxide/Sulfide heterostructures for industrially relevant oxygen evolution}, volume = {64}, year = {2025}, }
• (2025). Selective recognition and extraction of short-chain perfluoroalkyl carboxylates by a supramolecular receptor. ANGEW, 64(22), e202504880. (www)

  @article{ , abstract = {A supramolecular receptor for short-chain perfluoroalkyl carboxylates was developed. The receptor displays a cage-like geometry, with a defined binding site for the carboxylate head groups and an opening for the perfluoroalkyl side chains. The anionic guests are bound via multiple CH···O hydrogen bonds, as revealed by the crystallographic analysis of an adduct between the receptor and trifluoroacetate. The receptor can be used for the selective extraction of perfluoroalkyl carboxylates from buffered aqueous solutions containing fluoride, chloride, nitrate, carbonate, acetate, and phosphate.}, archive = {J_ANGEW}, author = {Xue-Zhi Wang and Damien W. Chen and Farzaneh Fadaei-Tirani and Xiao-Ping Zhou and Kay Severin}, doi = {10.1002/anie.202504880}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504880}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective recognition and extraction of short-chain perfluoroalkyl carboxylates by a supramolecular receptor}, volume = {64}, year = {2025}, }
• (2025). Simple “Directional trimming” strategy engineered platinum atomic clusters with controllable coordination numbers for efficient hydrogen evolution. ANGEW, 64(22), e202504828. (www)

  @article{ , abstract = {The coordination number (CN) in atomic cluster (AC) catalysts endows their catalytic performance with flexible tunability. However, the quantitative relationship between the CN and catalytic activity of atomic cluster catalysts remains ambiguity. Herein, inspired by the gardeners trimming plants branches to obtain ornamental value shape, we propose a “directional trimming” strategy to obtain a series of AC catalysts with wide range of Cl CN and establish an inverted volcano curve to explain the effect of CN on hydrogen evolution reaction (HER). Moreover, Pt/CB-90 (moderate Cl CN of 3.7) exhibits the lowest overpotential of 22.94 mV at 10 mA cm −2 and outstanding mass activity (25 times to commercial Pt/C). This proposed synthesis strategy fully utilizes the precursor atoms and is widely applicable. The reaction liquid can be reused up to 20 times to obtain 1130 mg catalysts without introducing any other chemicals. Additionally, theoretical calculations highlight the appropriate Cl CN benefits the HER on Pt 2 ACs. This fundamental understanding of the role of CN in catalytic activity offers valuable guidance to promote performance in various catalytic reactions.}, archive = {J_ANGEW}, author = {Fengkun Hao and Jing Zhong and Fengqian Hao and Shaorou Ke and Yanghong Li and Zhengyi Mao and Yunhu He and Tengshijie Gao and Linlin Wang and Shuohan Li and Minghao Fang and Zhaohui Huang and Xiaoxue Chang and Ruiwen Shao and Jian Lu and Xin Min}, doi = {10.1002/anie.202504828}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504828}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simple “Directional trimming” strategy engineered platinum atomic clusters with controllable coordination numbers for efficient hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Ultra-high optical anisotropy with UV transmission achieved by rational arrangement of extended π-conjugated groups. ANGEW, 64(22), e202504761. (www)

  @article{ , abstract = {Birefringent material serves as a cornerstone in photonic applications, including optical communications, polarization control, and laser technologies. The development of birefringent materials with large birefringence (Δ n > 0.3) and short ultraviolet (UV) cut-off edge ( λ cut-off edge < 400 nm) remains a significant challenge. Here, we demonstrate that properly aligned expanded π-conjugated groups provide a solution to balance the birefringence and UV transmittance. We report a new birefringent material, Li 3 (C 9 N 13 )·6H 2 O ( LCN ), in which the Li atoms and water molecules act as linkers to connect the birefringence-active group [C 9 N 13 ]. This crystal material exhibits a giant optical anisotropy (Δ n exp = 1.031 @ 546 nm), which is one of the highest among bulk crystal materials known to date. In addition, LCN shows a band gap of 3.62 eV, indicating its applicability in the UV optical range. Owing to favorable Li cation linkers and hydrogen bonding, the [C 9 N 13 ] groups achieve a perfectly coplanar arrangement, thereby maximizing the optical anisotropy. This work offers a novel strategy for the rational design of advanced birefringent materials.}, archive = {J_ANGEW}, author = {Danyang Dou and Chao Wei and Bingbing Zhang and Daqing Yang and Ying Wang}, doi = {10.1002/anie.202504761}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504761}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-high optical anisotropy with UV transmission achieved by rational arrangement of extended π-conjugated groups}, volume = {64}, year = {2025}, }
• (2025). Spiro units embedded in the B/N center for constructing highly efficient multiple resonance TADF emitters. ANGEW, 64(22), e202504723. (www)

  @article{ , abstract = {Departing from conventional molecular design strategies that rely on spiro units merely as peripheral components (side chains, terminal groups, or linkage units), we fully or partially incorporate the rigid 9,9′-spirobi[fluorene] (SF) unit into the boron/nitrogen multiple resonances (B/N-MR) emitting core, thereby successfully developing a series of proof-of-concept isomerized multiple resonance thermally activated delayed fluorescence (MR-TADF) emitters, namely SF-BN1, SF-BN2, SF-BN3, and SF-BN4. Remarkably, these novel emitters exhibit exceptionally narrow full-width at half-maximum (FWHM) values of 15–21 nm in dilute toluene solutions and high photoluminescence quantum yields (PLQYs) of up to 90% in doped films. The corresponding organic light-emitting diode (OLED) based on SF-BN1 achieved high external quantum efficiency (EQE) of up to 29.0%, with CIE coordinates of (0.13, 0.08), closely aligning with the BT.2020 blue emission standard. Sky-blue OLEDs based on SF-BN3 can achieve a high EQE of 29.8%, with a narrow FWHM value of 18 nm; the hyperfluorescent (HF) OLEDs based on SF-BN3 improved the EQE of 35.5%. Moreover, we elucidated subtle variations in the connectivity of chemical functional groups within emitters and the polar environment and doping concentrations of OLEDs, which can significantly impact these isomers' optical and electroluminescent (EL) properties.}, archive = {J_ANGEW}, author = {Lin Wu and Chunyu Liu and Denghui Liu and Deli Li and Wei Li and Jiasen Zhang and Xilin Mu and Ziru Xin and Bohong Liu and Hengxuan Qi and Zhiheng Wang and Di Liu and Shi-Jian Su and Yubo Zhou and Siyao Wu and Ziyi Ge}, doi = {10.1002/anie.202504723}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504723}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spiro units embedded in the B/N center for constructing highly efficient multiple resonance TADF emitters}, volume = {64}, year = {2025}, }
• (2025). Imaging heterogeneous patterns of aminopeptidase n activity in hierarchical tissue structures through high-resolution whole-organ 3D mapping. ANGEW, 64(22), e202504668. (www)

  @article{ , abstract = {Enzymes play a crucial role in regulating physiological functions, and abnormal enzyme activity is associated with various pathological conditions. Precise imaging of enzyme activity in tissues, providing detailed spatial and quantitative information, advances our understanding of physiological and pathological processes. Despite their importance, there is still a lack of methods for high-resolution 3D imaging of enzyme activity across entire tissues. In this research, we report a methodology for high-resolution, whole-organ 3D mapping of enzyme activity, which combines tissue clearing with an activity-based covalent chemical probe. Focusing on aminopeptidase N (APN) as a representative target of peptidase, we developed ANA- o -BODIPY, an activity-based covalent fluorescent probe compatible with tissue clearing for imaging APN activity. Upon activation by APN, ANA- o -BODIPY produces a reactive intermediate, aza-quinone methide, which covalently binds to proximal proteins. This covalent probe is successfully utilized to record the location of APN activity during the tissue-clearing process. By combining the probe with tissue clearing, we have achieved high-resolution 3D mapping of APN activity across whole organs for the first time. Moreover, this advancement allowed us to visualize the heterogeneity of APN activity in individual tubular structures and to uncover the inhibitory effects of different APN inhibitors.}, archive = {J_ANGEW}, author = {Bo Yi and Hiroyuki Yatabe and Daichi M. Sakamoto and Iori Tamura and Yutaro Saito and Naoki Yamada and Ruki Ashikaga and Masafumi Kuroda and Shimpei I. Kubota and Kazuki Tainaka and Shinsuke Sando}, doi = {10.1002/anie.202504668}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504668}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imaging heterogeneous patterns of aminopeptidase n activity in hierarchical tissue structures through high-resolution whole-organ 3D mapping}, volume = {64}, year = {2025}, }
• (2025). Vanillin-derived degradable and reprocessable liquid-crystalline epoxy resins with high intrinsic thermal conductivity. ANGEW, 64(22), e202504637. (www)

  @article{ , abstract = {The demand for high-functionality and miniaturized consumer electronics is driving the development of polymer packaging materials with intrinsically high thermal conductivity. Herein, a novel vanillin-based liquid-crystalline epoxy monomer (BEP) and three curing agents (ICA-1, ICA-2, and ICA-3) containing conjugated aromatic imine structures were synthesized. The results of X-ray diffraction measurements show that the structural order of the epoxy resins based on BEP and ICAs increases with the number of conjugated benzene rings in ICAs. Compared with the conventional epoxy reference (0.23 W m −1 K −1 ), the prepared liquid-crystalline epoxy resins exhibit enhanced intrinsic thermal conductivity (0.28–0.38 W m −1 K −1 ) due to the synergistic effect from the liquid-crystalline phase structure in BEP and the additional ordered structure (via π–π stacking) in ICAs. Both experimental and molecular dynamics calculation results show that the thermal conductivity of the epoxy resins is proportional to the length of the conjugated structures in ICAs. Owing to the incorporation of dynamic aromatic imine bonds, the three cured epoxy resins based on BEP and ICAs demonstrate excellent reprocessibility through imine metathesis and are chemically degradable in the amine solution.}, archive = {J_ANGEW}, author = {Jiaxin Qin and Zeyu Sun and Mingyan Wang and Jiamei Luo and Jingwang Zhang and Qianli Liu and Wanshuang Liu and Hui Zhang and Jianyong Yu}, doi = {10.1002/anie.202504637}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vanillin-derived degradable and reprocessable liquid-crystalline epoxy resins with high intrinsic thermal conductivity}, volume = {64}, year = {2025}, }
• (2025). Asymmetric structural design in cobaloxime-integrated covalent organic frameworks to facilitate photocatalytic overall water splitting. ANGEW, 64(22), e202504533. (www)

  @article{ , abstract = {Herein, we report a hydrogen-bonded supramolecular hybrid composed of a cobaloxime complex and a covalent organic framework (COF) that achieves photocatalytic overall water splitting. The designed COF features ternary units and dual linkages, which induce asymmetric linkers. Upon photoexcitation, this asymmetry facilitates directed electron transfer and spatially separated redox sites, resulting in a long-lived charge-separated state. Consequently, the COF, hydrogen-bonded with cobaloxime as a hydrogen (H 2 ) production cocatalyst, enables visible-light photocatalytic overall water splitting, simultaneously producing H 2 and hydrogen peroxide (H 2 O 2 ), outperforming the COFs with symmetric linker structures. This strategy of asymmetric structural design offers new insights for the design of photocatalysts with suppressed charge recombination for photocatalysis.}, archive = {J_ANGEW}, author = {Mingfei Yu and Junhan Huang and Qing Niu and Liuyi Li and Yan Yu and Jinhong Bi}, doi = {10.1002/anie.202504533}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504533}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric structural design in cobaloxime-integrated covalent organic frameworks to facilitate photocatalytic overall water splitting}, volume = {64}, year = {2025}, }
• (2025). Constructing biomimetic channels in hydrogen-bonded organic framework via post-synthesis for enhanced proton conductivity. ANGEW, 64(22), e202504396. (www)

  @article{ , abstract = {Proton transport channels in biological systems are constructed by the specific amino acid residues with hanging carboxylic acid groups acting as proton donors and acceptors, enabling rapid proton conduction via the Grotthuss mechanism. Hydrogen-bonded organic frameworks (HOFs) are promising candidates for artificially simulating proton channels due to their designable structure and abundant proton sources in the network. However, these protons were usually immobilized within hydrogen bonds between two building blocks, which require a high energy barrier for initiating proton transport. Post-synthetic modification (PSM) may be a viable solution to the above problems but has yet to be achieved in HOFs. Herein, we demonstrate for the first time that unoccupied carboxylic acid groups can be created through post-synthesis which further stabilizes water molecules to construct continuous proton channels, bringing boosted proton conductivity by three orders of magnitude. The structure transformation process and the intermediate can be identified clearly by crystallography with an unveiled mechanism. This work offers a new approach to constructing biomimetic channels for proton conduction and HOF functionalization.}, archive = {J_ANGEW}, author = {Yu-Lin Li and Jiang-Feng Lu and Qi Yin and Lei Cai and Hui-Jie Jiang and Chen Liu and Gang Xu and Tian-Fu Liu}, doi = {10.1002/anie.202504396}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504396}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing biomimetic channels in hydrogen-bonded organic framework via post-synthesis for enhanced proton conductivity}, volume = {64}, year = {2025}, }
• (2025). Intermolecular toroidal conjugation: Circularly stacked 16 π-planes formed by supramolecular assembly enabling cyclic charge and energy delocalization. ANGEW, 64(22), e202504353. (www)

  @article{ , abstract = {Toroidal conjugation is a unique mechanism for charge and exciton delocalization via through-space overlap among circularly stacked π-orbitals, but the examples have been limited to intramolecular phenomena, where π-planes are arranged around a hub molecule. In this study, we extend this concept to intermolecular phenomena and provide strong evidence for intermolecular toroidal conjugation in designed systems, in which a circular π-stacked array is formed by molecular self-assembly. X-ray single-crystal analysis unequivocally revealed a toroidal array of 16 π-planes formed by the supramolecular dimerization of phthalocyanines substituted with eight pillar-like diazapentacenes interdigitating their π-pillars. The experimentally determined interplanar distances in the toroidal π-stacking array were close enough to realize through-space conjugation. Various steady-state and time-resolved spectroscopies, supported by theoretical calculations, indicated the possibility of positive charge migration within the toroidal π-stacking array in the cationic and photoexcited states.}, archive = {J_ANGEW}, author = {Daisuke Sakamaki and Koki Tsubono and Minami Nakamura and Daiki Shimizu and Yasunori Matsui and Hiroshi Ikeda and Ko Furukawa and Hideki Fujiwara}, doi = {10.1002/anie.202504353}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intermolecular toroidal conjugation: Circularly stacked 16 π-planes formed by supramolecular assembly enabling cyclic charge and energy delocalization}, volume = {64}, year = {2025}, }
• (2025). Achieving buried Interface/Bulk synergistic passivation via chlorophyll derivative for efficient inverted perovskite solar cells. ANGEW, 64(22), e202504304. (www)

  @article{ , abstract = {Buried interfacial engineering is crucial for NiO x -based inverted perovskite solar cells (PSCs), while most passivation measures focus only on the interface and neglect the perovskite bulk. In this work, a stable free-base chlorin possessing an amino acid terminal (serinyl pyropheophorbide- a , SPPa) was synthesized as a functional chlorophyll derivative, and its trifluoroacetic acid and hydrogen chloride salts (SPPaX; X = TFA, HCl) were introduced into the NiO x /perovskite interface. Thanks to the high solubility in N , N -dimethylformamide and dimethyl sulfoxide, SPPaX can diffuse into the perovskite through the precursor. Insertion of SPPaX optimizes the interfacial energy band bending and minimizes interfacial defects, while the growth sites provided by SPPaX facilitate the formation of high-quality perovskite film with less lattice strain and high crystal orientation. Additionally, diffused SPPaX molecules in perovskite improve the crystallization process and decrease the internal defects of perovskite films. As a result, the SPPaX distributed throughout perovskite achieves a bulk/interface synergistic passivation effect at both the bulk and buried interface of the perovskite film. SPPaTFA-modified PSCs deliver a champion power conversion efficiency of 25.54% with a superior long-term stability under both light and thermal stress.}, archive = {J_ANGEW}, author = {Xianzhao Wang and Jun Jiang and Kun Hao and Ziyan Liu and Haoyu Ge and Xinhang Cai and Yuting Song and Lin Yang and Hai Xu and Aijun Li and Yuting Xu and Tsutomu Miyasaka and S. Sasaki and Hitoshi Tamiaki and Xiao-Feng Wang}, doi = {10.1002/anie.202504304}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504304}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving buried Interface/Bulk synergistic passivation via chlorophyll derivative for efficient inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Rapid water permeation by aramid foldamer nanochannels with hydrophobic interiors. ANGEW, 64(22), e202504170. (www)

  @article{ , abstract = {Aquaporins are natural proteins that rapidly transport water across cell membranes, maintaining homeostasis, whilst strictly excluding salt. This has inspired their use in water purification and desalination, a critical emerging need. However, stability, scalability, and cost have prevented their widespread adoption in water purification membrane technologies. As such, attention has turned to the use of artificial water channels, with pore-functionalized polymers and macrocycles providing a powerful alternative. Whilst impressive rates of transport have been achieved, the combination of a scalable, high-yielding synthesis and efficient transport has not yet been reported. Herein, we report such a system, with densely functionalized channel interiors, synthesized by high-yielding living polymerization with low polydispersities, showing high salt exclusion and excellent water transport rates. Our aramid foldamers create artificial water channels with hydrophobic interiors and single-channel water permeability rates of up to 10 8 water molecules per second per channel, approaching the range of natural aquaporins (c. 10 9 ). We show that water transport rates closely correspond to the helical length, with the polymer that most closely matches bilayer thickness showing optimal efficacy, as supported by molecular dynamics (MD) simulations. Our work provides a basis for the scalable synthesis of next-generation artificial water channels.}, archive = {J_ANGEW}, author = {Saquib Farooq and Javid Ahmad Malla and Miroslava Nedyalkova and Rafael V. M. Freire and Indradip Mandal and Aurelien Crochet and Stefan Salentinig and Marco Lattuada and Charlie T. McTernan and Andreas F. M. Kilbinger}, doi = {10.1002/anie.202504170}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504170}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid water permeation by aramid foldamer nanochannels with hydrophobic interiors}, volume = {64}, year = {2025}, }
• (2025). Management of intramolecular noncovalent interactions in dopant-free hole transport materials for high-performance perovskite solar cells. ANGEW, 64(22), e202504144. (www)

  @article{ , abstract = {Organic semiconductors with intramolecular noncovalent interactions are promising hole transport materials (HTMs) for efficient and stable perovskite solar cells (PSCs), but the effects of different types of noncovalent bonds on the properties of HTMs are rarely reported. Here, three thiazolo[5,4-d]thiazole (TzTz)-based HTMs with different side chains were developed. Compared with alkyl side chains, functional side chains can improve the crystallinity and charge transport ability of HTMs by forming intramolecular noncovalent interactions. However, the steric hindrance of S···O in TzTzTPA-SO distorted the molecular skeleton, leading to edge-on stacking and local aggregation of film. Fortunately, TzTzTPA-NH with intramolecular hydrogen bond showed high planarity, proper crystallinity, and preferred stacking orientation. Consequently, a remarkable power conversion efficiency (PCE) of 24.2% with a nice long-term stability was achieved by dopant-free TzTzTPA-NH-based PSCs, which is superior to the doped Spiro-OMeTAD-based PSCs. In addition, TzTzTPA-NH is well used as HTM in wide-bandgap PSCs and perovskite/organic tandem solar cells (TSCs). Encouragingly, the TSCs based on TzTzTPA-NH achieved an excellent PCE of 25.4%, which is the highest PCE of n-i-p perovskite/organic TSCs. This work clearly illustrates the effect of intramolecular noncovalent interactions on the properties of HTMs, and provides guidance for designing high-performance dopant-free HTMs in PSCs.}, archive = {J_ANGEW}, author = {Gang Xie and Qifan Xue and Haojia Ding and Aihui Liang and Jiaxin Liu and Yonglong Yang and Jing Wang and Xunfan Liao and Yonggang Min and Yiwang Chen}, doi = {10.1002/anie.202504144}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Management of intramolecular noncovalent interactions in dopant-free hole transport materials for high-performance perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Efficient nickel precatalysts for suzuki-miyaura cross-coupling of aryl chlorides and arylboronic acids under mild conditions. ANGEW, 64(22), e202504108. (www)

  @article{ , abstract = {The synthesis and catalytic properties of Ni(II) complexes with the general formula Ni(NHC)[P(OR) 3 ](Ar)Cl are described. These complexes are air-stable and extremely effective precatalysts in the Suzuki-Miyaura cross-coupling reaction. The reaction protocols described allow for the cross-coupling of aryl chlorides and arylboronic acids, employing low catalytic loading, to deliver a large variety of functionalized biaryl compounds. For the coupling of aryl chlorides with N -heterocyclic boronic acids, TBAF was used as an additive to afford nitrogen-containing biaryl products. Overall, these reaction protocols operate at room or mild temperatures and can be applied to a variety of electronically and sterically differentiated coupling partners. Fundamental insights into the mechanism of this reaction, including the proposed formation of the catalytically active Ni(NHC)[P(O i -Pr) 3 ] and resting state species, are also reported.}, archive = {J_ANGEW}, author = {Morgan E. John and Michael J. Nutt and Josephine E. Offer and Jeremy A. Duczynski and Ken Yamazaki and Tomoya Miura and Stephen A. Moggach and George A. Koutsantonis and Reto Dorta and Scott G. Stewart}, doi = {10.1002/anie.202504108}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504108}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient nickel precatalysts for suzuki-miyaura cross-coupling of aryl chlorides and arylboronic acids under mild conditions}, volume = {64}, year = {2025}, }
• (2025). From theophylline to adenine or preQ1: Repurposing a DNA aptamer revealed by crystal structure analysis. ANGEW, 64(22), e202504107. (www)

  @article{ , abstract = {Aptamers, which are short, single-stranded DNA or RNA, are capable of binding to a wide array of targets with exceptional selectivity. Those with high affinity for theophylline have the potential to serve as biosensors, crucial for tracking theophylline levels in the treatment of respiratory conditions. Despite the extensive structural characterization of the RNA theophylline aptamer, the DNA counterpart's ligand-recognition mechanism has remained unclear. Here, we elucidate the DNA theophylline aptamer's ligand-binding mechanism through high-resolution crystal structures of its complexes with theophylline, 3-methylxanthine, and hypoxanthine. Guided by these structural insights, we computationally redesigned the theophylline-binding pocket via rational mutagenesis of key nucleotides, generating novel aptamers selective for adenine and prequeuosine (preQ 1 ) ligands. These engineered aptamers were validated through biochemical and crystallographic analyses. By integrating structural biology with computational design, our work provides a relatively simple and effective method for developing new aptamers. While this strategy does not supplant SELEX, it serves as a beneficial complement to it.}, archive = {J_ANGEW}, author = {Xiaowei Lin and Yuanyin Huang and Jinchao Huang and Hao Yuan and Yuhang Luo and Zhizhong Lu and Ying Ao and Jian Huang and Shuo-Bin Chen and Zhichao Miao and Lin Huang}, doi = {10.1002/anie.202504107}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504107}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From theophylline to adenine or preQ1: Repurposing a DNA aptamer revealed by crystal structure analysis}, volume = {64}, year = {2025}, }
• (2025). Anode engineering with pH-neutral conjugated polyelectrolyte enabling over 19% efficiency in organic solar cells. ANGEW, 64(22), e202504085. (www)

  @article{ , abstract = {The lack of effective hole-transporting layers (HTLs) materials has become a significant bottleneck in the advancement of organic solar cells (OSCs). Particularly, to obtain sufficient doping properties, most HTLs have to be used by mixing with substantial amounts of acid, which causes serious corrosion problems. Herein, by optimizing molecular conformation, we designed and synthesized two conjugated polyelectrolytes (CPEs) that exhibited superior hole-transporting capability without involving acid addition. The PEP-BT features a planar conjugated backbone constructed from the nonfused segment, which leads to an enhanced doping effect and highly ordered molecular arrangement. and reduced π–π stacking from 4.13 to 3.85 Å. These contributed to the outstanding hole collection performance of polyoxometalate-doped PEP-BT:POM4 while maintaining a neutral pH. The binary OSC showed a photovoltaic efficiency of 19.16%, illustrating an unprecedented example that a CPE-based HTL can provide a photovoltaic efficiency exceeding 19% in OSCs. Moreover, as another evidence of high-performance HTL, the organic light-emitting diode incorporating PEP-BT:POM4 exhibited a superior luminous efficiency to the reference device, along with a decrease of 0.4 V for turn-on voltage. The results from this work demonstrate the great potential of CPEs as HTL materials.}, archive = {J_ANGEW}, author = {Yao Tong and Luxin Feng and Jiayu Li and Heng Liu and Cunbin An and Shouke Yan and Bowei Xu}, doi = {10.1002/anie.202504085}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anode engineering with pH-neutral conjugated polyelectrolyte enabling over 19% efficiency in organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Ultra-narrowband organic electroluminescence with external quantum efficiency of 40% from indolocarbazole-embedded multiple resonance emitters. ANGEW, 64(22), e202504002. (www)

  @article{ , abstract = {The demand for ultra-high-definition display technology has spurred the prosperity of multiple resonance induced thermally activated delayed fluorescence (MR-TADF) materials with narrow full-width at half-maximum (FWHM) and high efficiency, making them highly promising candidates for high-color-purity organic light-emitting diodes (OLEDs) displays. Indolocarbazole, a highly rigid aza-polycyclic aromatic hydrocarbon framework, has shown significant potential as a building block for constructing MR-TADF emitters with ultra-narrowband emission (<20 nm). However, it remains a great challenge to construct ultra-narrowband indolocarbazole-embedded MR-TADF emitters with emission maxima less than 500 nm. Here, two MR-TADF emitters, DBN- am ICz and DBN- bm ICz, are constructed by adopting meta -N–π–N-type indolocarbazole as core framework and achieve ultra-narrowband blue–green emission in toluene solution with peaks of both 490 nm and FWHMs of 18 and 19 nm, respectively. OLEDs incorporating emitters DBN- am ICz and DBN- bm ICz demonstrate excellent electroluminescence (EL) performances, with maximum external quantum efficiencies (EQEs) of 40.1% and 35.5%, and FWHMs of 21 and 24 nm, respectively. This study represents the first report of dual-boron-containing MR emitters derived from indolocarbazole with emission below 500 nm, filling a gap in the development of indolocarbazole-embedded dual-boron-containing blue–green MR-TADF emitters.}, archive = {J_ANGEW}, author = {Linjie Li and Tingting Huang and Yincai Xu and Yupei Qu and Weibo Cui and Lu Xu and Chenglong Li and Yue Wang}, doi = {10.1002/anie.202504002}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202504002}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-narrowband organic electroluminescence with external quantum efficiency of 40% from indolocarbazole-embedded multiple resonance emitters}, volume = {64}, year = {2025}, }
• (2025). First encapsulation of organometallic single-molecule magnet into single-walled carbon nanotubes. ANGEW, 64(22), e202503979. (www)

  @article{ , abstract = {An air-sensitive DyCp 3 (Cp − = cyclopentadienyl) single-molecule magnet (SMM) complex ( 1 ) is encapsulated into single-walled carbon nanotubes (SWCNTs) to construct hybrid materials that are resistant to moisture and oxygen. The hybrid materials with independent slow-magnetic-relaxing centers are expected to become a key component of the next generation of information process devices based on spintronics. The resilience to moisture and oxygen further broadens its manufacturing methods and application scenarios. Furthermore, upon encapsulation into SWCNTs, DyCp 3 exhibited clear ac frequency dependence in the ac magnetic susceptibility at a zero-dc field. This indicates that the guest molecule's slow magnetic relaxation properties are preserved, which is crucial and necessary to realize SMMs-based quantum information processing, by allowing a sufficient time window for quantum gate operations. This result exemplifies that encapsulation of air-sensitive organometallic SMMs into SWCNTs enhances their chemical stability and their magnetic relaxation time at a zero-dc magnetic field, which provides a novel method for their further applications.}, archive = {J_ANGEW}, author = {Haitao Zhang and Ryo Nakanishi and Takefumi Yoshida and Masahiko Nishijima and Koji Harano and Yoji Horii and Masahiro Yamashita}, doi = {10.1002/anie.202503979}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503979}, shortjournal = {Angew. Chem. Int. Edit.}, title = {First encapsulation of organometallic single-molecule magnet into single-walled carbon nanotubes}, volume = {64}, year = {2025}, }
• (2025). Intercalation of transition-metal complexes into 2D hybrid perovskites for tailored dual-band emission. ANGEW, 64(22), e202503957. (www)

  @article{ , abstract = {The recently emerging two-dimensional (2D) hybrid lead-halide perovskites are mostly templated by “inert” organic cations, limiting their light emission solely from the inorganic components. Using “optically active” organic cations can grant access to the coupling between the two luminescent components, potentially leading to new excitation and emission pathways. However, employing optically active organic cations requires delicate design and complicated synthesis. To circumvent these problems, transition-metal complexes (e.g., Cu 2+ and Ni 2+ ) were intercalated in 2D perovskites and reported, for the first time, the photoluminescence (PL) profiles. 2D perovskites incorporating transition-metal complexes can be considered a molecular “type II” heterostructure where the “conduction band” is localized on the complexes and the “valence band” on the haloplumbate layers. As evident in the absorption and PL spectra of the materials, the “type II” configuration allows inter-band transitions to occur in addition to intraband within 2D Pb─Br layers. This makes the material's PL excitation wavelength dependent, allowing activation of only inter-band or inter-band plus intraband transitions by certain wavelengths. As the transition-metal complexes are highly tunable, this extra variable renders 2D hybrid perovskites a fertile playground for PL engineering as desired outcome can be targeted through fine-tailoring of inorganic lattice structures and selection of complexes with specific electronic configuration.}, archive = {J_ANGEW}, author = {Ksenia Chaykun and Benny Febriansyah and Trang Thuy Nguyen and Yulia Lekina and Yongxin Li and Shuzhou Li and Jinghua Teng and Zhi-Kuang Tan and Nripan Mathews and Zexiang Shen}, doi = {10.1002/anie.202503957}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503957}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intercalation of transition-metal complexes into 2D hybrid perovskites for tailored dual-band emission}, volume = {64}, year = {2025}, }
• (2025). Leveraging polaron effect for solar-driven efficient peroxymonosulfate activation in water purification. ANGEW, 64(22), e202503901. (www)

  @article{ , abstract = {Peroxymonosulfate (PMS) represents a promising advanced oxidation technique for the treatment of refractory pollutants; however, its application is limited by high costs resulting from excessive usage due to low activation efficiency. In this study, we formulated a sunlight-driven Cu 1 –O v /TiO 2 catalyst with surface electron polaron sites to activate PMS for the degradation of contaminants, achieving a record reaction rate of k = 2.998 min −1 even with a low PMS dosage of 0.3 mM. The adsorption process and electron transfer kinetics were significantly enhanced with surface polaron sites in Cu 1 –O v /TiO 2 , which facilitated the activation of PMS and increased the reaction rate constant k by 29.1 times compared with that of TiO 2 /PMS under illumination. Additionally, we verified that light irradiation promotes transfer from the non-free-radical pathway to the efficient free-radical pathway in mechanism of PMS activation. Our designed sunlight-driven flow-through PMS setup achieves a removal rate exceeding 90% for 7 days of outdoor operation at 3.2 × 10 2 L m −2 h −1 , the feasibility of which is further proven in regions around the world by analysis of solar intensity. This study presents a demonstration of economical PMS application in water purification worldwide, with an estimated cost of 0.135 $ m −3 .}, archive = {J_ANGEW}, author = {Zhetong Yang and Xiaoming Xu and Zhonghua Li and Changhao Liu and Jingwen Jiang and Shiyu Zhang and Jiaming Miao and Wei Liu and Wangxi Liu and Zhigang Zou and Zhaosheng Li}, doi = {10.1002/anie.202503901}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging polaron effect for solar-driven efficient peroxymonosulfate activation in water purification}, volume = {64}, year = {2025}, }
• (2025). Unraveling CO-tolerance mechanism in proton exchange membrane fuel cells via operando infrared spectroscopy. ANGEW, 64(22), e202503868. (www)

  @article{ , abstract = {CO poisoning remains a critical challenge for proton exchange membrane fuel cells (PEMFCs). Current studies of CO tolerance primarily focus on solid/liquid interfaces (in situ conditions), which differ significantly from PEMFCs' solid/liquid/gas triple-phase interfaces ( operando conditions) in microenvironment and mass transport. Herein, we developed an operando transmission infrared spectroscopy method that enables direct observation of CO tolerance mechanism on commercial PtRu/C catalysts in PEMFCs. Under in situ conditions, hydrogen oxidation reaction (HOR) activity is governed by CO mass transfer, and is insensitive to the availability of active sites, while it is highly sensitive under operando conditions due to enhanced mass transfer, thereby aggravating CO poisoning effects. Notably, 76% of HOR activity can recover upon switching to pure H 2 . Based on CO band evolution, we proposed a new pathway beyond the traditional bifunctional mechanism of CO tolerance: CO migrates from Pt to Ru sites, undergoing oxidation at potentials as low as 0.01 V versus reversible hydrogen electrode (RHE).}, archive = {J_ANGEW}, author = {Jia-Feng Du and Jin-Yu Ye and Chao Yang and Chun-Yu Qiu and Nan Fang and Yu-Cheng Wang and Zhi-You Zhou and Shi-Gang Sun}, doi = {10.1002/anie.202503868}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503868}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling CO-tolerance mechanism in proton exchange membrane fuel cells via operando infrared spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Breaking the activity-stability trade-off of RuO2 via metallic ru bilateral regulation for acidic oxygen evolution reaction. ANGEW, 64(22), e202503733. (www)

  @article{ , abstract = {Developing highly efficient acidic oxygen evolution reaction (OER) electrocatalysts is crucial for proton exchange membrane water electrolyzer. RuO 2 electrocatalysts, which followed a kinetically favorable lattice oxygen mechanism, perform a preferable intrinsic activity, but poor stability for acidic OER. Recent work often sacrifices the intrinsic activity of RuO 2 to enhance stability. The balance between the activity and stability of RuO 2 -based catalysts is still overlooked in current research. Here, we report a controlled method to introduce metallic Ru onto RuO 2 catalysts to form the Ru 4+ ─O─Ru 0 interfacial structure for decreasing the Ru 4+ oxidation state and promoting deprotonation kinetics. Metallic Ru can serve as the electron donor to lower the oxidation state of *V o -RuO 4 2− in Ru/RuO 2 for stabilizing the structure of *V o -RuO 4 2− -Ru/RuO 2 to favour the acidic OER stability. Moreover, the deprotonation kinetics via the interfacial oxygen site between Ru 4+ and Ru 0 is significantly enhanced on Ru/RuO 2 catalysts to improve the acidic OER activity. This work offers a unique perspective to balance the acidic OER activity and stability of RuO 2 .}, archive = {J_ANGEW}, author = {Qian Lu and Jinjie Liu and Xiaohong Zou and Birou Huang and Weixing Wu and Jun Yin and Zhao-Qing Liu and Ying Wang}, doi = {10.1002/anie.202503733}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503733}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking the activity-stability trade-off of RuO2 via metallic ru bilateral regulation for acidic oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). B ← n lewis pair fusion of N,N-diaryldihydrophenazines: Effect on structural, electronic, and emissive properties. ANGEW, 64(22), e202503658. (www)

  @article{ , abstract = {Doping of polycyclic aromatic hydrocarbons (PAHs) with boron and/or nitrogen is emerging as a powerful tool to tailor the electronic structure and photophysical properties. As N- doped analogues of anthracene, N,N -dihydrophenazines play important roles as redox mediators, battery materials, luminophores, and photoredox catalysts. Although benzannulation has been used successfully as a structural constraint to control the excited state properties, fusion of the N-aryl groups to the phenazine backbone has rarely been explored. Herein, we report the first examples of dihydrophenazines, in which the N-aryl groups are fused to the phenazine backbone via B←N Lewis pair formation. This results in structural rigidification, locking the molecules in a bent conformation, while also modulating the electronic structure through molecular polarization. B─N fusion in BNPz1−BNPz3 induces a quinoid resonance structure with significant C─N(py) double bond character and reduces the antiaromatic character of the central pyrazine ring. Borylation also lowers the HOMO/LUMO (highest occupied/lowest unoccupied molecular orbital) energies and engenders bathochromic shifts in the emission. Further rigidification in the solid state gives rise to enhanced emission quantum yields, consistent with aggregation-induced emission enhancement (AIEE) observed upon water addition to solutions in tetrahydrofuran (THF). The demonstrated structural control and fine-tuning of optoelectronic properties are of great significance to potential applications as emissive materials and in photocatalysis.}, archive = {J_ANGEW}, author = {Ashutosh Sahoo and Ashvini Patel and Roger A. Lalancette and Frieder Jäkle}, doi = {10.1002/anie.202503658}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {B ← n lewis pair fusion of N,N-diaryldihydrophenazines: Effect on structural, electronic, and emissive properties}, volume = {64}, year = {2025}, }
• (2025). Strategy formulation for mitigating capacity fading of na-layered oxides. ANGEW, 64(22), e202503587. (www)

  @article{ , abstract = {The mechanisms underlying capacity fading during cycling in layered oxide cathode materials for sodium-ion batteries remain inadequately understood. It is essential to elucidate the reasons and propose effective strategies. Here, the capacity-fading mechanism of commercial NaFe 1/3 Mn 1/3 Ni 1/3 O 2 is due to the dissolution of iron ions. Additionally, the extraction of sodium ions (after the Fe 3+ /Fe 4+ reaction) lowers the energy level of NaFe₁/₃Mn₁/₃Ni₁/₃O₂ below that of the electrolyte solvent, thereby inducing solvent decomposition. We establish screening criteria for electrolyte additives through theoretical calculations to improve capacity retention. We identified a series of nitrogen-containing Lewis base additives that can kinetically bind efficiently to iron ions in NaFe₁/₃Mn₁/₃Ni₁/₃O₂ and thermodynamically exhibit stronger electron-donating abilities than the solvents. A new compound, sodium bis(trimethylsilyl)amide (which has not been studied as a Na-ion battery additive before), is selected through the Reaxys database (out of 61 molecules) because it is commercially available at a low price and is relatively stable in the electrochemical process. Such an additive is demonstrated to greatly improve the Coulombic efficiency and reduce the dissolution of iron ions of NaFe₁/₃Mn₁/₃Ni₁/₃O₂//hard carbon cells.}, archive = {J_ANGEW}, author = {Jun Pan and Yanhong Liu and Yuanwei Sun and Okkyun Seo and Rosantha Kumara and Yuwei Liu and Takeshi Watanabe and Jian Yang and Shixue Dou and Chongyin Yang and Qingyu Yan and Srinivasan Madhavi and Fuqiang Huang}, doi = {10.1002/anie.202503587}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503587}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strategy formulation for mitigating capacity fading of na-layered oxides}, volume = {64}, year = {2025}, }
• (2025). Base-catalyzed remote hydrogermylation of olefins. ANGEW, 64(22), e202503573. (www)

  @article{ , abstract = {Although remote functionalization has emerged as a powerful strategy for modifying unactivated sites that are traditionally challenging to functionalize, there has been no remote hydrogermylation known to date. This work reports the first remote hydrogermylation of alkenes, achieved through a rare base-catalyzed approach-completely free of added transition metal catalysts. The methodology is operationally simple, versatile, and capable of achieving up to 8-carbon chain walks, overcoming the previous two-carbon limit of base-mediated processes.}, archive = {J_ANGEW}, author = {Eric Ahrweiler and Aymane Selmani and Franziska Schoenebeck}, doi = {10.1002/anie.202503573}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503573}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Base-catalyzed remote hydrogermylation of olefins}, volume = {64}, year = {2025}, }
• (2025). A modular approach toward BN-embedded terrylene diimides. ANGEW, 64(22), e202503571. (www)

  @article{ , abstract = {This work presents the first example of heteroatoms embedded terrylene diimides (TDIs), which were synthesized from the BN-embedded imide building block in a modular manner. Through the control of the amount and orientations of the BN unit(s), the manipulation of dipole moments of the obtained BN-embedded terrylene diimides (BN-TDIs) was achieved, which in turn extended the fluorescence of BN-TDIs to near infrared region. The structures of BN-TDIs were established via single crystal X-ray diffractions. Stronger carbonyl-π interactions were observed for BN-TDIs in their crystal structures compared with that of TDI, which could be utilized in the construction of supramolecular architectures. The organic thin film transistors based on BN-TDIs were also fabricated. BN-TDI-S showcased higher electron mobilities than that of TDI, indicating the potential of BN-TDIs as promising n-type organic semiconductors.}, archive = {J_ANGEW}, author = {Kexiang Zhao and Yu-Chun Xu and Jing-Cai Zeng and Yang-Kun Qu and Jie-Yu Wang and Jian Pei}, doi = {10.1002/anie.202503571}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A modular approach toward BN-embedded terrylene diimides}, volume = {64}, year = {2025}, }
• (2025). Mannich-type polymers: A versatile platform for water-degradable, malleable, and environmentally responsive networks. ANGEW, 64(22), e202503555. (www)

  @article{ , abstract = {Polymer waste poses a significant environmental challenge, with current recycling strategies often hindered by inefficient waste collection systems, high production costs, and limited material recyclability. While extensive efforts have been directed toward upcycling or degrading commercial polymers, as well as developing sustainable alternatives, many approaches remain constrained by their reliance on harsh conditions, specialized catalysts, or complex processing methods. In this study, we present a novel strategy to address the challenges by developing mechanically robust polymer networks that are readily degradable in water within 30 days. Our approach leverages a guanidine-based Mannich-type reaction utilizing three low-cost starting materials—guanidine hydrochloride, aldehyde, and diamine—under mild conditions. Unlike traditional thermosets, which are often difficult to recycle, our polymer networks exhibit exceptional processability, enabling the fabrication of various forms, and demonstrate responsiveness to moisture. These properties, coupled with degradability, make them viable candidates for diverse applications. By introducing a scalable and sustainable pathway for designing next-generation recyclable polymers, our work advances the field of dynamic covalent chemistry and presents a novel class of sustainable polymer networks with significant potential for reducing environmental impact.}, archive = {J_ANGEW}, author = {Honglu Huang and Hongjie Liu and Feichen Cui and Zixiao Wang and Yang Sui and Xin Liu and Yunhao Yao and Jiajun Yan}, doi = {10.1002/anie.202503555}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503555}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mannich-type polymers: A versatile platform for water-degradable, malleable, and environmentally responsive networks}, volume = {64}, year = {2025}, }
• (2025). Integrating electronic-storage piperazine into covalent organic frameworks for promoting oxygen reduction reaction. ANGEW, 64(22), e202503434. (www)

  @article{ , abstract = {Metal-free covalent organic frameworks (COFs) have emerged as potential electrocatalysts for oxygen reduction reaction (ORR) in new environmental-friendly electrochemical energy conversion technologies. However, their catalytic activity is hindered by inefficient electron transfer from electrodes to catalytic sites along extended frameworks. To overcome this bottleneck, herein, we first incorporated redox-active piperazine units into the COFs to catalyze ORR. The redox-active piperazine units enable to storage electrons, thus accelerate the electron transfer to the catalytic sites. Furthermore, the introduction of ─OH group-containing building blocks induces keto-enol tautomerism (enabling reversible ─OH / ─C═O interconversion), improving framework polarity with a dipole moment of 6.87 Debye (5.8 times increase compared to non-hydroxylated COFs). This polarity enhancement strengthens the intermediates binding ability, thereby improving the catalytic activity. As a result, the optimized PD-COF-OH exhibits a high half-wave potential of 0.76 V, turnover frequency (TOF) of 0.045 s −1 , and electrochemically active surface area of 9.4 mF cm −2 , surpassing most reported metal-free COFs. Theoretical calculations further reveal synergistic roles of ─OH and ─C═O groups in stabilizing OOH* and OH* intermediates, contributing to the improved catalytic activity. This work establishes a novel design paradigm for catalytic COFs through a rational integration of electron reservoir units and tautomerism-enabled polarity modulation.}, archive = {J_ANGEW}, author = {Shuang Zheng and Yubin Fu and Xiaoyu Xu and Qing Xu and Gaofeng Zeng}, doi = {10.1002/anie.202503434}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503434}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating electronic-storage piperazine into covalent organic frameworks for promoting oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Boron-fluoride dual-atom synergistic regulated interface coating enables stable zn-metal anodes. ANGEW, 64(22), e202503376. (www)

  @article{ , abstract = {Aqueous zinc-based batteries provide promising opportunities for next-generation rechargeable batteries. Nevertheless, Zn anode encounters severe challenges, such as Zn dendrite formation, surface corrosion, and hydrogen evolution reaction (HER). Here, we report a strategy to spontaneously construct a boron−fluoride dual-atom regulated SEI (ZnBOF), which involves the formation of a B-compound coating through an etching process followed by an in situ F substitution during the initial electrochemical cycling. The ZnBOF/Zn anode benefits preferential deposition of Zn 2+ along the (002) plane without Zn dendrite, and the side reactions including by-product and HER are dramatically suppressed. A combination of characterization methods, such as X-ray absorption spectroscopy, shows that the B-containing passivation layer facilitates the transport of Zn 2+ and mitigates water-related side reactions, and the F atoms serve as zincophilic sites that enhance the transfer kinetics of Zn 2+ . As expected, the well-designed ZnBOF/Zn anode exhibits ultra-stable Zn plating/stripping for 5000 h at 2 mA cm −2 . The assembled ZnBOF/Zn||MnO 2 batteries show impressive cycling stability, remaining 96.2% of the initial capacity (234.3 mAh g −1 ) after 1700 cycles at 1.0 A g −1 . Therefore, this work reveals a dual-atom synergistic regulated strategy to fabricate a robust SEI for Zn anode, which contributes to the development of aqueous zinc-based batteries.}, archive = {J_ANGEW}, author = {Chenglong Liu and Tian Liu and Ruiqi Liu and Yuying Liu and Jin Ma and Qianqian Ji and Na Li and Chao Wang and Qichong Zhang and Wensheng Yan}, doi = {10.1002/anie.202503376}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503376}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boron-fluoride dual-atom synergistic regulated interface coating enables stable zn-metal anodes}, volume = {64}, year = {2025}, }
• (2025). Simple Boron–Nitrogen covalent bond constructs multi-resonance TADF emitters: Ultra-narrowband deep-blue electroluminescence. ANGEW, 64(22), e202503320. (www)

  @article{ , abstract = {High-efficiency, pure deep-blue emitters are critically needed to meet the rising demands of ultra-high-definition displays. Although high-order B/N-doped polycyclic aromatic hydrocarbons (PAHs) leveraging multi-resonance (MR) effects show promise, their complex syntheses and large molecular weights hinder practical application. Here, we report a compact MR framework featuring three nitrogen-linked boron centers, synthesized at the gram scale via a single-step, amine-directed borylation. This emitter displays deep-blue emission with an ultra-narrow full-width at half-maximum (FWHM) of 13 nm and achieves an order-of-magnitude increase in the reverse intersystem crossing rate constant ( k RISC ) compared to previous BN-bond-based blue MR emitters. Theoretical studies reveal that its π-extended framework and partially distorted geometry synergistically minimize structural relaxation to reduce FWHM and enhance spin–orbit coupling to facilitate efficient spin-flip processes. As a result, the corresponding deep-blue organic light-emitting diodes exhibit an FWHM of 15 nm and a high maximum external quantum efficiency ( η EQE,max ) approaching 30% at color coordinates of (0.155, 0.060), rivaling the leading performance of deep-blue OLEDs based on conventional B/N-doped frameworks.}, archive = {J_ANGEW}, author = {Yuxi Guo and Wentao Xie and Zeyuan Ye and Ke Xu and Zhenghao Zhang and Zhengqi Xiao and Jingsheng Miao and Yang Zou and Cheng Zhong and Xiaojun Yin and Chuluo Yang and Xiaosong Cao}, doi = {10.1002/anie.202503320}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503320}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simple Boron–Nitrogen covalent bond constructs multi-resonance TADF emitters: Ultra-narrowband deep-blue electroluminescence}, volume = {64}, year = {2025}, }
• (2025). A light-driven electrochromic materials-based nanomotor for H2S-controlled drug release in synergistic cancer chemotherapy immunotherapy. ANGEW, 64(22), e202503297. (www)

  @article{ , abstract = {Nanomotors hold tremendous potential for drug delivery. However, current nanomotors face limitations that compromise efficiency of drug utilization, including the use of inorganic materials with suboptimal soft interface and biocompatibility, uncontrollable drug release, insufficient directional control, and slow movement speeds. Herein, we present a novel near-infrared (NIR) light-driven porous unsymmetric nanomotor with ultrafast motion, which utilizes hydrogen sulfide (H 2 S)-responsive cationic organic π-electron structure-based electrochromic material ( F1 2+ ) for the payload and controlled release of anionic anticancer drugs, enabling synergistic cancer chemotherapy and immunotherapy. We demonstrate that the nanomotor can precisely target tumors driven by thermophoresis, tumor-targeting peptide (RGD), and H 2 S (highly expressed in tumors and acted as chemoattractants), which induces chemotactic behavior to guide nanomotors into tumors. Once in the tumors, the cationic F1 2+ is reduced to the diene F2 upon reaction with H 2 S, activating the nanomotor's NIR fluorescence for real-time monitoring of drug delivery and release in vivo. Upon exposure to H 2 S, the nanomotor undergoes disassembly due to the disruption of electrostatic interactions between the anionic anticancer drugs and the cationic F1 2+ , leading to the precise and controlled drug release, ensuring uniform distribution across the tumor. This innovative strategy would open avenues for delivering mRNA vaccines or other anionic drugs.}, archive = {J_ANGEW}, author = {Luyan Wu and Xiang Cao and Yusuke Ishigaki and Qiang Tong and Fangqi Yang and Huihui Lin and Takanori Suzuki and Quli Fan}, doi = {10.1002/anie.202503297}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503297}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A light-driven electrochromic materials-based nanomotor for H2S-controlled drug release in synergistic cancer chemotherapy immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Reactive hydrogen species behaviors on Pd/TiN: In situ SERS guided regulation for chemoselective hydrogenation. ANGEW, 64(22), e202503279. (www)

  @article{ , abstract = {Uncovering the H 2 dissociation and H-spillover behaviors of the generated reactive hydrogen species on catalyst surfaces is crucial for achieving efficient and chemoselective hydrogenation. However, those behaviors remain largely elusive given the challenges of directly observing H atoms, the smallest atoms in the element table. Herein, we explored the Pd site–specific D 2 cleavage and the H-spillover behaviors of dissociated D on the titanium nitride (TiN) support via in situ surface-enhanced Raman spectroscopically (SERS). Besides facilitated forming Pd single atom (Pd 1 ), fully exposed Pd cluster (Pd n ) and Pd nanoparticles, dissociated D 2 on Pd sites (indicated by ν Pd–D at 1,800 cm −1 ), spillover to TiN, and formation of the N─D bond (indicated by ν N–D at 2,400 cm −1 ) were spectroscopically traceable. Combined with density functional theory (DFT) calculation, Pd n is identified as the most favorable site for the provision of reactive H through hydrogen spillover. Moreover, we propose ν Pd-D and the ν N-D /ν Pd-D ratio as the index to relative amounts of Pd 1 and Pd n sites, respectively, and develop an in situ SERS-based method to study the synthesis–structure–activity relationship of Pd/TiN catalyst with an optimized structure for chemoselective hydrogenation.}, archive = {J_ANGEW}, author = {Xiaoling Zhang and Qiushi Shen and Xinyu Li and Li Wen and Jiefang Sun and Jingfu Liu and Chunyang Liao and Sijin Liu and Guibin Jiang and Rui Liu}, doi = {10.1002/anie.202503279}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503279}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reactive hydrogen species behaviors on Pd/TiN: In situ SERS guided regulation for chemoselective hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Constructing robust Electrode/Electrolyte interphases for highly stable Lithium–Sulfurized polyacrylonitrile batteries. ANGEW, 64(22), e202503214. (www)

  @article{ , abstract = {Lithium–sulfurized polyacrylonitrile (SPAN) batteries show great promise for energy storage, but are plagued by poor cycling stability, which can be attributed to unfavorable electrode/electrolyte interphases for both anode and cathode. Here we design and achieve the anion-moderate solvation structure based interconnected clusters in electrolyte by regulating the interactions of solvent with Li + and diluent to construct robust anode/electrolyte and cathode/electrolyte interphases simultaneously for high-performance Li–SPAN batteries. The optimal electrolyte endows Li plating/stripping with a high Coulombic efficiency of 99.47% at 1 mA cm −2 in Li||Cu cells. The Li–SPAN batteries show excellent cycling stability with a high capacity retention of 94.21% after 1215 cycles. Moreover, the assembled pouch-type Li–SPAN battery under limited electrolyte condition (2.40 g Ah −1 ) achieves a capacity of 3.75 Ah, corresponding to a high energy density of 180 Wh kg −1 based on the total mass of the battery. This work provides a good electrolyte design principle to construct robust anode/electrolyte and cathode/electrolyte interphases for batteries.}, archive = {J_ANGEW}, author = {Siyuan Shao and Jinze Hou and Youxuan Ni and Chunyan Zhu and Shuang Wu and Xinyi Liu and Can Wang and Kai Zhang and Zhenhua Yan and Yong Lu and Jun Chen}, doi = {10.1002/anie.202503214}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503214}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing robust Electrode/Electrolyte interphases for highly stable Lithium–Sulfurized polyacrylonitrile batteries}, volume = {64}, year = {2025}, }
• (2025). Ion-docking effect enabling rechargeable high-voltage Magnesium–Iodine/Chlorine battery. ANGEW, 64(22), e202503209. (www)

  @article{ , abstract = {Rechargeable magnesium (Mg) batteries represent a promising energy storage system by offering low cost and dendrite-less propensity. However, the limited selection of cathode materials, and often with low voltage and capacity, constrain Mg batteries. Herein, by exploiting the ion-docking effect between two halogen species—iodine cations (I + ) and chlorine anions (Cl − )—we activate the cathodic activity of halogens and develop a magnesium–iodine/chlorine (Mg-I/Cl) battery prototype with high energy and power density. The ion-docking effect enables I + and Cl − to mutually balance and disperse their charges, and weakens the coordination strength between Cl − and Mg 2+ while enhancing the stability of I + , thus facilitating the multi-electron (2 + 1/3) redox reactions of halogens. We also find the solvation state of iodine species determines the reaction process of the I 0 /I 3 − /I − redox couples. The here-developed magnesium–iodine/chlorine battery features an impressively high discharge plateau of up to 3.0 V with a high capacity exceeding 400 mAh g −1 , and demonstrates a stable lifespan for 500 cycles, with the ability of ultra-fast charging at 20C and low-temperature cycling under −30 °C. These findings may provide new insights for developing high-energy-density Mg battery systems.}, archive = {J_ANGEW}, author = {Longyuan Guo and Tong Li and Ting Yang and Zhenglin Hu and Aoxuan Wang and Jiayan Luo}, doi = {10.1002/anie.202503209}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503209}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ion-docking effect enabling rechargeable high-voltage Magnesium–Iodine/Chlorine battery}, volume = {64}, year = {2025}, }
• (2025). Electron-deficient cobalt centers realized by rational p─π conjugation regulation for high-performance Li─S batteries. ANGEW, 64(22), e202503174. (www)

  @article{ , abstract = {Rational design of the coordination environment of single-atom catalysts (SACs) can enhance their catalytic activity, which is of great significance for high-loading and lean-electrolyte lithium-sulfur (Li─S) batteries. Inspired by the Lewis acid–base theory, we design a unique coordination environment for constructing electron-deficient Co SACs on carbon nanotubes (named as CNT@f-CoNC), which function as a Lewis acid, to enhance the chemisorption and catalytic activity towards polysulfides (Lewis base). Compared with porphyrin-like Co SACs, electron-deficient Co SACs (Lewis acid) exhibit much stronger binding affinity towards polysulfides (Lewis base) and a significantly lower energy barrier of the rate-determining step in the sulfur reduction reaction. As expected, even with a high sulfur loading (6.9 mg cm −2 ) and lean electrolyte to sulfur (E/S) ratio (4.0 µL mg −1 ), the areal capacity still reaches 7.7 mAh cm −2 . Moreover, a 1.6 Ah-class pouch cell is successfully assembled under the harsh conditions and delivers an energy density of 422 Wh kg −1 . This work provides novel insights into enhancing the electrochemical performance of Li─S batteries by modulating the local electronic density of metal sites through the rational design of the coordination environment.}, archive = {J_ANGEW}, author = {Mai Li and Hui Liu and Huifang Li and Deyan Luan and Zhiming Liu and Xiong Wen (David) Lou}, doi = {10.1002/anie.202503174}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503174}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron-deficient cobalt centers realized by rational p─π conjugation regulation for high-performance Li─S batteries}, volume = {64}, year = {2025}, }
• (2025). Enantioconvergent deacylative functionalization toward α-quaternary nitriles. ANGEW, 64(22), e202503149. (www)

  @article{ , abstract = {The use of readily available prochiral or racemic quaternary carbons to access enantioenriched ones offers a promising alternative to conventional synthesis from tertiary or planar substrates. Unlike desymmetrization, which modifies an existing substituent with limited reactivity, a functional group swap can install a new motif, which is structurally distinct and nonderivable from the replaced group. However, achieving enantioconvergence in these quaternary-to-quaternary transformations is challenging, especially for acyclic stereocenters. Here, we report that acyl groups of β-ketonitriles can be stereoselectively replaced by allyl, propargyl, or benzyl moieties using easily accessible alcohols under palladium catalysis. The deacylative functionalization proceeds through a retro-Claisen-type elimination of ketonitrile with alkoxide and the absence of diastereoisomerism in the resulting ketenimine anion assists the subsequent asymmetric addition. Together with the pair of α-substituents, the retained nitrile and the incoming alkyl motif instill significant derivatization potential into the enantioenriched quaternary stereocenters.}, archive = {J_ANGEW}, author = {Minghao Zhang and Zhongxing Huang}, doi = {10.1002/anie.202503149}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503149}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioconvergent deacylative functionalization toward α-quaternary nitriles}, volume = {64}, year = {2025}, }
• (2025). Harnessing molecular recognition for small-molecule-mediated reversible photochemical control over mRNA translation. ANGEW, 64(22), e202503078. (www)

  @article{ , abstract = {Chemical probes that control the function of complex RNA molecules offer unique opportunities to interrogate biological systems. In this study, we demonstrate that a small molecule ligand selectively recognizes and undergoes traceless, reversible photocrosslinking to PreQ 1 RNA aptamers. This effect is selective and dependent on both the chemical structure and RNA sequence/structure. A homogeneously modified, caged mRNA construct containing a PreQ 1 aptamer and an eGFP or wild type p53 coding sequence displayed repressed translation in vitro or in cells until irradiated with 302 nm light, resulting in cleavage of the photocage and restoration of translation. This method demonstrates for the first time that aptamer-based molecular recognition of a small molecule ligand can be used to precisely and photochemically activate the translation of a complex mRNA in cells.}, archive = {J_ANGEW}, author = {Shaifaly Parmar and Logan Tenney and Xiao Liang and John T. Routzahn and Christopher D. Sibley and John S. Schneekloth}, doi = {10.1002/anie.202503078}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503078}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing molecular recognition for small-molecule-mediated reversible photochemical control over mRNA translation}, volume = {64}, year = {2025}, }
• (2025). Synthetic reversible fibrous network hydrogels based on a double-helical polyelectrolyte. ANGEW, 64(22), e202503030. (www)

  @article{ , abstract = {The unique mechanical properties of fibrous networks in biological tissues have inspired the development of synthetic fibrous network hydrogels, yet few polymers can reversibly form such structures. Here, we report the first reversible fibrous network hydrogel composed of synthetic polyelectrolytes with extremely rigid conformation (persistence length is ∼1 µm), made up of double-helical poly(2,2′-disulfonyl-4,4′-benzidine terephthalamide) (PBDT) and tetrabutylphosphonium bromide ([P 4444 ]Br). The hydrogel exhibits a unique sol–gel transition, triggered by the hydrophobicity increase of [P 4444 ]Br above lower critical solution temperature (LCST). This drives PBDT aggregation into fibrous bundles through electrostatic interactions. These bundles grow and branch into a continuous network, with the molecular rigidity of PBDT's double-helix conformation being key to gel formation. The hydrogel displays strain-stiffening mechanical responses akin to biological systems and shows a significant hysteresis (21 °C) between heating and cooling cycles. Uniquely, the effects of salts on the transition temperature deviate from the Hofmeister series, highlighting coordination with sulfonate groups as the dominant factor. Leveraging its modulus change during gelation, the hydrogel was successfully applied as a spray coating on superhydrophobic vertical Teflon surfaces. This study broadens the scope of thermoreversible hydrogels introducing gelation mechanisms for rigid polyelectrolytes and demonstrates their potential in advanced coatings.}, archive = {J_ANGEW}, author = {Haonan Zheng and Kaizheng Liu and Yongheng Cui and Legeng Li and Qinbo Liu and Yongjun Men}, doi = {10.1002/anie.202503030}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503030}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthetic reversible fibrous network hydrogels based on a double-helical polyelectrolyte}, volume = {64}, year = {2025}, }
• (2025). A triatomic cobalt catalyst for oxygen electrocatalysis. ANGEW, 64(22), e202503019. (www)

  @article{ , abstract = {The advancement of rechargeable zinc–air batteries significantly depends on bifunctional oxygen electrocatalysts to provide outstanding oxygen reduction/evolution reaction (ORR/OER) performance. However, it is still challenging to design electrocatalysts with excellent bifunctional activity and stability. Here, we adopt an ultrafast printing method to efficiently embed a triatom cobalt complex precursor onto graphene nanosheets to obtain a triatomic catalyst (Co 3 -NG), exhibiting a durable and excellent bifunctional catalyst in the electrocatalytic ORR ( E half-wave = 0.903 V) and OER ( E j = 10 = 1.596 V). The Co 3 -NG-assembled zinc–air battery can output a maximum power density of 189.0 mW cm −2 at 330 mA cm −2 and can be charged and discharged over 3000 cycles, significantly outperforming the Pt/C + RuO 2 benchmark (146.5 mW cm −2 , 360 cycles) under testing conditions of 25 °C. In situ XAS analysis and theoretical calculations disclose that Co 3 ON 6 is the catalytic site for bifunctional ORR/OER electrocatalysis. The constructed triangular pyramidal active sites effectively regulate the d-band center and electronic configuration and promote the adsorption/desorption of oxygen intermediates. This work uncovers that the geometry and electronic structure of triatomic active centers play a key role in improving bifunctional ORR/OER performance for electrochemical energy applications.}, archive = {J_ANGEW}, author = {Tianmi Tang and Xiaoqin Xu and Xue Bai and Changmin Hou and Tao Gan and Zhenlu Wang and Jingqi Guan}, doi = {10.1002/anie.202503019}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503019}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A triatomic cobalt catalyst for oxygen electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Balancing intermediates formation on atomically pd-bridged Cu/Cu2O interfaces for kinetics-matching electrocatalytic C─N coupling reaction. ANGEW, 64(22), e202503011. (www)

  @article{ , abstract = {The electrochemical C─N coupling of CO 2 and nitrogenous species provides a promising approach for synthesizing valuable chemicals such as urea, amides, and other C─N compounds. However, the unbalanced formation of C- and N-intermediates results in slow C─N coupling kinetics. Herein, we report an atomically Pd-bridged Cu/Cu 2 O (Pd 1 –Cu/Cu 2 O) catalyst, synthesized through the in situ electrochemical reconstruction of Pd 1 –Cu 2 Te nanosheets. This catalyst features Pd–Cu dual sites that significantly enhance C─N coupling both thermodynamically and kinetically. The reconstructed Pd 1 –Cu/Cu 2 O achieves a urea yield rate of 31.8 mmol h −1 g cat. −1 and a Faradaic efficiency (FE) of 42.2%, along with excellent stability over 100 h. In situ spectroscopic examinations and theoretical calculations disclose that the Pd–Cu dual sites on Pd 1 –Cu/Cu 2 O modulate the reduction kinetics of CO 2 and NO 3 − , balance the formation of crucial *CO and *NH 2 intermediates, and lower the energy barrier for C─N coupling, thereby facilitating urea synthesis. Furthermore, the Pd 1 –Cu/Cu 2 O enables the unprecedented C─N coupling of aniline with CO, resulting in a remarkable acetanilide yield rate of 1021.2 mmol h −1 g cat. −1 with an FE of 23.7%. This heteroatom bridging strategy offers a new pathway for designing efficient electrocatalyst for the synthesis of C─N coupled compounds.}, archive = {J_ANGEW}, author = {Yan Wang and Shuai Xia and Kui Chen and Jianfang Zhang and Cuiping Yu and Jingjie Wu and Peng Wang and Wenjun Zhang and Yucheng Wu}, doi = {10.1002/anie.202503011}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202503011}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Balancing intermediates formation on atomically pd-bridged Cu/Cu2O interfaces for kinetics-matching electrocatalytic C─N coupling reaction}, volume = {64}, year = {2025}, }
• (2025). Novel light-promoted bioorthogonal reaction via molecular recombination for the synthesis of polysubstituted pyrrole and its application in in vitro and in vivo studies. ANGEW, 64(22), e202502953. (www)

  @article{ , abstract = {Bioorthogonal chemistry has revolutionized organic, medicinal, and biochemical research by designing and developing selective and rapid reactions that do not interfere with biological processes. Despite significant advancements, the existing bioorthogonal reactions can normally introduce only one functional group to a biomolecule, limiting their versatility in biological systems. In this study, we report a novel light-promoting reaction, namely light-promoted bioorthogonal multifunctionalized molecular recombination (LBMR) reaction, that can facilitate the synthesis of polysubstituted pyrroles via molecular editing and recombination of isoxazole-3-carboxylate and isoxazole-3-carboxylic acid derivatives. The proposed LBMR reaction exhibited rapid kinetics, high efficiency, wide substrate scope, and the potential for in situ fluorescence imaging under normal physiological conditions without the need for a catalyst. The LBMR reaction allowed incorporating multiple functional groups and using well-soluble carboxylic salts as bioorthogonal substrates. The in vitro experiments performed in different types of cells and the in vivo studies performed on zebrafish demonstrated the potential applicability of the proposed LBMR for biological imaging. This work not only introduces a new photo-bioorthogonal reaction paradigm but also expands the scope of bioorthogonal chemistry, paving the way for future applications in biomedical research.}, archive = {J_ANGEW}, author = {Aoting Ni and Chenlu Zhang and Nanxia Zhang and Rui Tao and YiBin Zhang and Leyi Guo and Ziheng Yu and Yuchen Wei and Ding Du and Tao Lu and Yadong Chen and Jie Feng}, doi = {10.1002/anie.202502953}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502953}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Novel light-promoted bioorthogonal reaction via molecular recombination for the synthesis of polysubstituted pyrrole and its application in in vitro and in vivo studies}, volume = {64}, year = {2025}, }
• (2025). Compacting molecular stacking and inhibiting self-aggregation in fullerene transporting layer for efficient and stable perovskite solar cells. ANGEW, 64(22), e202502950. (www)

  @article{ , abstract = {The underdevelopment of electron transport layer (ETL) materials remains a critical bottleneck limiting the overall photovoltaic performance of inverted perovskite solar cells (PSCs). Fullerene derivatives, such as PCBM, are widely employed ETL materials in PSCs due to their excellent electron affinity and energy level alignment with the perovskite layer. However, PCBM suffers from high energy disorder, self-aggregation predilection, and insufficient defect passivation ability, leading to significant charge carrier recombination and accumulation at interfaces. Herein, a phosphate-substituted fullerene derivative, FuPE, is developed to enhance the performance of PCBM-based ETLs for PSCs. Incorporating FuPE efficiently compacts molecular stacking, enforces crystallinity and intermolecular interaction, suppresses self-aggregation, and improves interfacial compatibility of the FuPE:PCBM blend. Such endows the FuPE:PCBM blend film with enhanced electron mobility (0.183 cm 2 V −1 s −1 ), lower trap density, more uniform film morphology, and superior defect-passivation ability, compared to the PCBM pristine one. Consequently, PSCs employing FuPE:PCBM as the ETL achieve reduced trap-assisted recombination, enhanced charge carrier extraction, and thus a remarkable power conversion efficiency exceeding 26% alongside improved operational stability. This work highlights an effective strategy for optimizing fullerene-based ETLs, advancing the development of highly efficient and durable PSCs.}, archive = {J_ANGEW}, author = {Dan He and Jiahao Zhang and Xue-Yuan Gong and Xinying Ruan and Xin-Bo Ma and Chaoyi Yao and Xingxing Shen and Ming-Hua Li and Jianqi Zhang and Jin-Song Hu and Chunru Wang and Fuwen Zhao}, doi = {10.1002/anie.202502950}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502950}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Compacting molecular stacking and inhibiting self-aggregation in fullerene transporting layer for efficient and stable perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Construction of multistep charge transfer pathways in Bi0@Bi3+-KNbO3 for significantly accelerated photoconversion of waste plastics. ANGEW, 64(22), e202502874. (www)

  @article{ , abstract = {Photoconversion of waste plastics into valuable CO and CH 3 COOH represents a ground-breaking strategy for addressing plastic pollution issues. However, this process currently encounters significant challenges, primarily due to the limitation of catalyst activity and the difficulty in breaking C─C bonds. Herein, we present a novel approach that integrates multistep charge transfer pathways with photothermal-driven reactions to improve photoconversion efficiency. By incorporating Bi 0 /Bi 3+ metal as an electron transport mediator for multistep charge transfer, we markedly enhanced the separation and transport of photoelectrons, thereby accelerating the generation of active species. Meanwhile, the heat generated by the localized surface plasmon resonance effect of Bi 0 drove the reactions related to the photoconversion of polypropylene. Subsequently, the photoconversion rates of PP into CO by Bi 0 @Bi 3+ -KNbO 3 reached 209.41 µmol g cat −1 h −1 , which is 27.55 times higher than that achieved with KNbO 3 . Furthermore, the dual Bi–Nb sites effectively stabilize the key intermediate *COOH, thereby promoting the production of CH 3 COOH at a rate of 213.00 µmol g cat −1 h −1 . This strategy of boosting photoconversion activity of PP into CO and CH 3 COOH offers an effective green solution to the serious issue of plastic pollution.}, archive = {J_ANGEW}, author = {Xulong Fan and Lidan Lan and Yuanyu Chang and Long Yang and Yun Huang and Yi Dan and Long Jiang}, doi = {10.1002/anie.202502874}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502874}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of multistep charge transfer pathways in Bi0@Bi3+-KNbO3 for significantly accelerated photoconversion of waste plastics}, volume = {64}, year = {2025}, }
• (2025). Imino-pyrrole Zn(II) complexes for the rapid and selective chemical recycling of commodity polymers. ANGEW, 64(22), e202502845. (www)

  @article{ , abstract = {Three imino-pyrrole zinc complexes were prepared and applied to the rapid degradation of polylactic acid (PLA) and the depolymerization of bisphenol A polycarbonate (BPA-PC) and polyethylene terephthalate (PET). PLA alcoholysis proceeded rapidly at a range of conditions, including reflux in air. Remarkable activity was demonstrated for the solvent-free methanolysis of PLA at mild conditions with full conversion reached in 11 min at 80 °C. Various conditions were investigated including a range of PLA sources and, importantly, catalyst recycling was demonstrated. The methanolysis of BPA-PC and the glycolysis of PET were achieved, the latter giving full conversion after 1.5 h for all catalysts. The chemical recycling of mixed plastic feedstocks was investigated, including the selective and sequential degradation of a PLA/BPA-PC mixture with a single catalyst and solvent.}, archive = {J_ANGEW}, author = {Jack A. Stewart and Louis T. W. Powell and Matthew J. Cullen and Gabrielle Kociok-Köhn and Matthew G. Davidson and Matthew D. Jones}, doi = {10.1002/anie.202502845}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502845}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imino-pyrrole Zn(II) complexes for the rapid and selective chemical recycling of commodity polymers}, volume = {64}, year = {2025}, }
• (2025). Engineering covalent organic frameworks for photocatalytic overall water vapor splitting. ANGEW, 64(22), e202502821. (www)

  @article{ , abstract = {Photocatalytic overall water vapor splitting (OWVS) into H 2 and O 2 not only owns the potential of avoiding the backward reaction of O 2 reduction reaction reforming H 2 O, but also realizes H 2 production without available liquid water. However, this attempt is still a blank due to the weak absorption of photocatalysts to water vapor. Herein, we report the first example of visible-light-driven OWVS by combining the water-adsorbing ability and photocatalytic activity of covalent organic frameworks (COFs). The overall water splitting (OWS) activity of Tp-COF skeleton was realized by introducing tripyridyltriazine segment. The Pt@Tp-TAPyT-COF achieves high visible-light-driven H 2 and O 2 evolution rates (HER and OER) of 148.4 and 74.8 µmol g −1 h −1 , respectively. Under water vapor conditions with diverse relative humidities (RHs), the Pt@Tp-TAPyT-COF could drive OWVS even without backward reaction. By further optimizing the structure of β -ketoamine section, it was found that the Pt@DHTA-TAPyT-COF showed optimal OWVS activity, with the H 2 and O 2 evolution rate of 51.2 and 25.6 µmol g −1 h −1 under RH = 88%, respectively. The advantage of OWVS compared to traditional solid–liquid OWS was further confirmed by a continuous activity test of 45 h. Further experiments and theoretical calculations indicated that carbonyl-O and pyridine-N atoms in COFs serve as water-absorbing sites, and the absorbed water molecules could promote water-splitting activity of active sites in COFs simultaneously.}, archive = {J_ANGEW}, author = {Jin-Da Qu and Ya Wang and Ting-Ting Sun and Xiao-Yu Chu and Yan-Xia Jiang and Nan-Nan Zhang and Zhi-Hao Zhao and Hong Dong and Ya-Qian Lan and Feng-Ming Zhang}, doi = {10.1002/anie.202502821}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502821}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering covalent organic frameworks for photocatalytic overall water vapor splitting}, volume = {64}, year = {2025}, }
• (2025). High-entropy environments enable metal surface-catalyzed nucleophilic electrooxidation. ANGEW, 64(22), e202502776. (www)

  @article{ , abstract = {Electrochemical biomass conversion offers a sustainable route to diverse products, minimizing environmental impact. However, conventional 5-hydroxymethylfurfural electrooxidation (HMFOR) catalysts such as Ni(OH)₂ and NiS suffer from low conductivity, poor stability, and limited active sites. This work introduces a CoNiMnMoPd high entropy alloy (HEA) to address these limitations by simultaneously maintaining high conductivity, stability, and a high Ni oxidation state, enabling nucleophilic dehydrogenation. The HEA catalyst achieved a 92.5% 2,5-furandicarboxylic acid (FDCA) Faradaic efficiency, 89.5% HMF conversion, and 95.8% FDCA selectivity, maintaining performance for over 100 h. Experimental and theoretical investigations revealed that the multielement composition of the HEA enabled Ni sites to maintain a high-valence state, serving as the primary adsorption sites for HMF, and the dehydrogenation reaction occurs preferentially at non-Ni sites within the HEA. Compared to monometallic Ni, the d-band center shift and reduced antibonding filling contributed to a decrease in the energy barrier for the rate-determining step (RDS) in the HMF-to-FDCA conversion, from 0.770 to 0.567 eV. This work offers novel insights for the development of Ni-based HEA catalysts for biomass valorization.}, archive = {J_ANGEW}, author = {Pengfei Ren and Tao Gan and Jian Cai and Jiace Hao and Zechao Zhuang and Chanyuan Jin and Wenchao Zhang and Mingliang Du and Han Zhu}, doi = {10.1002/anie.202502776}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy environments enable metal surface-catalyzed nucleophilic electrooxidation}, volume = {64}, year = {2025}, }
• (2025). Cooperative redox reactions encoded by two gene clusters enable intermolecular cycloaddition cascade for the formation of meroaspochalasins. ANGEW, 64(22), e202502766. (www)

  @article{ , abstract = {Meroaspochalasins (mAPOs) are a group of intricate heteromers comprising two distinct subunits, dienophile aspochalasin, and diene isobenzofuran, of which the biosynthetic mechanism is of great interest yet unrevealed. In this study, two independent biosynthetic gene clusters (BGCs), flas and epi , being responsible for the biosynthesis of aspochalasin B ( 7 ) and pre-diene hemiacetal 21 (or 26 ), respectively, were identified in the filamentous fungus Aspergillus flavipes . In vivo and in vitro studies proved that a flavin adenine dinucleotide (FAD)-dependent oxidase FlasF in the flas cluster catalyzes the crucial oxidation to generate diverse aspochalasin monomers, particularly the dienophile 7 . Interactive reduction catalyzed by the short-chain alcohol dehydrogenase/reductase (SDR) FlasG and endogenous NADPH further increases the complexity of this anabolic network. The cytochrome P450 enzyme EpiC and SDR enzyme EpiD in the epi cluster collaboratively catalyze the formation of pre-diene 21 (or 26 ), which can spontaneously dehydrate to yield a diene, leading to the nonenzymatic cascade of [4 π + 2 π ] Diels–Alder and formal [5 π + 2π] cycloaddition reaction to generate mAPO dimers and trimer progressively. Moreover, the FAD-dependent oxidase EpiG catalyzes the hydroxylation at the C3 position of the diene as a critical step in the formation of mAPO trimers.}, archive = {J_ANGEW}, author = {Pengkun Li and Jie Meng and Xiaotian Zhang and Xiaopeng Zhang and Yonghao Ye and Yunpeng Zhao and Xuenian Huang and Ziou Zha and Zhenhua Guan and Suitian Lai and Zhe Chen and Zengwei Luo and Jianping Wang and Chunmei Chen and Junjun Liu and Lianghu Gu and Yuhui Sun and Shuming Li and Hucheng Zhu and Ying Ye and Yuan Zhou and Yonghui Zhang}, doi = {10.1002/anie.202502766}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502766}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative redox reactions encoded by two gene clusters enable intermolecular cycloaddition cascade for the formation of meroaspochalasins}, volume = {64}, year = {2025}, }
• (2025). Enantio- and diastereoselective synthesis and spiral-stair-like single helix assembly of figure-eight cyclophenylenes. ANGEW, 64(22), e202502764. (www)

  @article{ , abstract = {Helix assemblies of chiral molecules can transfer microscopic unimolecular chirality to macroscopic supramolecular chirality, enhancing various chiral properties. In addition to the commonly observed spiral-column-like helix assembly, a small number of spiral-stair-like helix assemblies have also been reported in aromatic nanocarbons with multiple chirality-related irregularities. However, they require separation of diastereomers and/or enantiomers or do not have stable chirality. Here, we report the enantio- and diastereoselective synthesis of figure-eight [10]cyclophenylenes with stable helical chirality by the rhodium-catalyzed four consecutive intramolecular [2 + 2 + 2] cycloadditions of dodecaynes with two flexible biphenyl units. The chiral figure-eight [10]cyclophenylene with ethyl and methyl side chains exhibits the spiral-stair-like single helix assembly in the crystal due to CH–π and CH–O interactions and good CPL properties in solution. Experimental verification of the enantio- and diastereodetermining steps of four consecutive [2 + 2 + 2] cycloadditions is also reported.}, archive = {J_ANGEW}, author = {Kohei Adachi and Juntaro Nogami and Daisuke Hashizume and Daiki Tauchi and Masashi Hasegawa and Ken Tanaka}, doi = {10.1002/anie.202502764}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502764}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantio- and diastereoselective synthesis and spiral-stair-like single helix assembly of figure-eight cyclophenylenes}, volume = {64}, year = {2025}, }
• (2025). High-entropy deep eutectic solvent achieves ultra-low polarization zinc anode chemistry. ANGEW, 64(22), e202502761. (www)

  @article{ , abstract = {Deep eutectic solvents (DESs), a new class of green solvents, have emerged as promising candidates for electrolytes due to their exceptional electrochemical stability. However, the DES always exhibits unacceptable polarization of cells due to its high viscosity and low ionic conductivity, which limit its practical application in batteries. In this work, the cell polarization of DES is effectively reduced to a level comparable to that of pure aqueous electrolytes by increasing the entropy of DES via the disorder-making strategy of solvation structure. Theoretically, constructing the high-entropy deep eutectic solvent (HEDES) promotes the formation of more aggregates with high disorder, which accelerates mass transfer kinetics. As a result, the proposed HEDES (configuration entropy 17 times higher than traditional electrolyte) can achieve durable zinc plating/stripping behavior for more than 2000 h with low polarization and still maintain good stability even in extreme environments. The cylindrical zinc-ion capacitor under gram-level loading can achieve a high discharge current up to 3 A, providing ideas for the design of electrolytes for zinc-based energy storage devices.}, archive = {J_ANGEW}, author = {Nengze Wang and Ming Zhang and Xiaohe Ren and Mengxuan Sun and Tianning Pian and Pinji Wang and Yang-feng Cui and Xiaojun Yao and Chunyang Jia and Hui Ying Yang}, doi = {10.1002/anie.202502761}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502761}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy deep eutectic solvent achieves ultra-low polarization zinc anode chemistry}, volume = {64}, year = {2025}, }
• (2025). Guiding design of mn-rich phosphate cathodes with less intrinsic antisite defects. ANGEW, 64(22), e202502758. (www)

  @article{ , abstract = {The serious voltage hysteresis phenomenon in Na 3 MnTi(PO 4 ) 3 has received extensive research interests, which is determined by the intrinsic-antisite-defects (IASDs) of Mn 2+ resided in Na vacancies (Mn/Na □ ) in structure. However, a general guideline to decrease IASDs is still lacking for the design of a higher-performance Na 3 MnTi(PO 4 ) 3 system. Herein, we find that generation of Mn/Na□ IASDs in Na 3 MnTi(PO 4 ) 3 system is mainly related to Na vacancies and weaker Mn─O bonds in structure. The more Na vacancies, the more probability for Mn 2+ occupation on Na sites. Meanwhile, the weaker Mn─O bond, the more probability for Mn 2+ delocalization/migration to other sites, finally leading to the Mn/Na □ IASDs. To decrease Mn/Na □ IASDs, we propose to introduce dopants with lower valence (vs. Ti 4+ ), lower electronegativity (vs. Ti 4+ ), and good solid solubility in Na 3 MnTi(PO 4 ) 3 system. Based on the guiding rule, we have selected several doping cations (including Cr 3+ , Ti 3+ , Fe 3+ , and V 3+ ) to construct a Na-rich environment and enhance Mn─O strength. Among various dopants, the substitution of V 3+ for Ti 4+ leads to the strongest Mn–O interaction, thus demonstrating the most effective suppression of Mn/Na □ IASDs. With these discoveries, we further developed a series of V-doped Mn-richer phosphate cathodes, Na 3.3+ y Mn 1.15 V y Ti 0.85- y (PO 4 ) 3 (0.1 ≤ y ≤ 0.25) as the promising candidates for Na-ion batteries.}, archive = {J_ANGEW}, author = {Chunliu Xu and Weibo Hua and Guilin Feng and Zhao Chen and Ruijuan Xiao and Qinghua Zhang and Weiqing Yang and Chao Yang and Junmei Zhao and Yong-Sheng Hu}, doi = {10.1002/anie.202502758}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502758}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Guiding design of mn-rich phosphate cathodes with less intrinsic antisite defects}, volume = {64}, year = {2025}, }
• (2025). Rapid access to conjugated Z,Z,Z-trienes. ANGEW, 64(22), e202502713. (www)

  @article{ , abstract = {Intercepting reactions have recently emerged as an innovative approach in organic synthesis, allowing chemists to harness reactive intermediates to access structures and functionalities that conventional methods cannot easily achieve. By deliberately manipulating reaction pathways, this strategy provides a unique avenue to explore unusual reactivities and complex molecular architectures. In this work, we have developed a new protocol for the nucleophile-intercepted Beckmann fragmentation reaction (NuBFr). Employing tropone oxime tosylate – a simple and readily accessible precursor – and a diverse set of nucleophiles generated in situ from alcohols, phenols, thiols and alkynes with strong bases, we successfully synthesized a library of novel conjugated Z , Z , Z -trienecarbonitrile derivatives. This method facilitates rapid access to the conjugated Z , Z , Z -triene motif, a structural feature rarely encountered in synthetic chemistry. Our computational studies indicate that the NuBFr reaction likely proceeds through the formation of a bicylic azirine intermediate. The resulting Z , Z , Z -trienecarbonitriles could undergo an unprecedented thermally induced 8π/6π/4π electrocyclization cascade sequence to produce trisubstituted olefins. This sequence underscores the fundamental value of these motifs in pushing the boundaries of unusual reactivities in organic synthesis.}, archive = {J_ANGEW}, author = {Nhan Nu Hong Ton and Binh Khanh Mai and Thomas Fallon and Thanh Vinh Nguyen}, doi = {10.1002/anie.202502713}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502713}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid access to conjugated Z,Z,Z-trienes}, volume = {64}, year = {2025}, }
• (2025). Charge-transport divergence in ultrastable heterometal-oxo clusters exerting significant effect on photoreactivity. ANGEW, 64(22), e202502654. (www)

  @article{ , abstract = {The transfer path of photogenerated charges greatly affects the final photocatalytic performance, but this important fact has not been clearly demonstrated experimentally. Here, we construct an ultrastable crystalline catalytic system including three heterometal-oxo clusters, Bi 8 M 7 -TBC4A (M = group IVB metal-Ti/Zr/Hf), which include cubic metal-oxo cluster core with eight Bi atoms at the vertices, one M atom at the body center, and six M atoms above the cubic face centers. It is worth noted that the change of group IVB elements in Bi 8 M 7 -TBC4A can specifically modulate the LUMO-HOMO orbitals to distribute on different active metal atoms. This allows it to be an excellent model system to verify the effect of the transport paths of photogenerated charges on photoreactivity. In model reaction based on CO 2 photoreduction, Bi 8 Ti 7 -TBC4A displays superior photocatalytic CO 2 -to-HCOOH conversion rate of 3580.02 µmol g −1 , which is twice that of Bi 8 Zr 7 -TBC4A and 4 times that of Bi 8 Hf 7 -TBC4A . In situ characterization accompanied by density functional theory (DFT) indicate that the difference in orbital hybridization between Bi and IVB group elements largely affects the orbital distribution of frontier molecular orbital levels in Bi 8 M 7 -TBC4A , leading to the transport of photogenerated charges to metal active sites with different reactivities, and thus widely differing photocatalytic performances. This is the first model catalyst system that explores the effect of different photogenerated charge transport pathways on photoreactivity.}, archive = {J_ANGEW}, author = {Jing-Wen Shi and Ning Li and Yan Liang and Shan Xu and Long-Zhang Dong and Dongdi Zhang and Jingyang Niu and Run-Han Li and Jiang Liu and Shun-Li Li and Ya-Qian Lan}, doi = {10.1002/anie.202502654}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Charge-transport divergence in ultrastable heterometal-oxo clusters exerting significant effect on photoreactivity}, volume = {64}, year = {2025}, }
• (2025). Engineered probiotics enable targeted gut delivery of dual gasotransmitters for inflammatory bowel disease therapy. ANGEW, 64(22), e202502588. (www)

  @article{ , abstract = {Inflammatory bowel disease (IBD) remains an incurable condition, often accompanied by high rates of anxiety and depression, further diminishing the quality of life of patients. Endogenous gasotransmitters, such as carbon monoxide (CO) and hydrogen sulfide (H₂S), exhibit potent anti-inflammatory and immunomodulatory effects. However, their therapeutic application is limited by challenges in targeted delivery to affected tissues. Here, we propose a novel strategy for targeted gut delivery of CO/H 2 S through engineering Escherichia coli Nissle 1917 (EcN) with CO/H 2 S-releasing copolymer (POSR) loading. This engineered probiotic (POSR@EcN) enhances EcN colonization in the intestine and enables controlled, localized release of CO/H 2 S at inflamed sites. The release of CO/H 2 S modulates inflammation, restores intestinal barrier integrity, and reshapes gut microbiota by promoting beneficial bacteria and increasing short-chain fatty acids production, effectively alleviating IBD symptoms. Notably, targeted CO/H 2 S delivery also elevates neuroprotective metabolites like indoleacetic acid and γ-aminobutyric acid, reducing neuroinflammation via the gut-brain axis and mitigating anxiety- and depression-like behaviors in IBD mice. This approach highlights the potential of EcN as a probiotic carrier for the targeted delivery of gasotransmitters, offering a promising strategy for IBD treatment.}, archive = {J_ANGEW}, author = {Tengfei Ma and Guihai Gan and Jian Cheng and Zhiqiang Shen and Guoying Zhang and Shiyong Liu and Jinming Hu}, doi = {10.1002/anie.202502588}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502588}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered probiotics enable targeted gut delivery of dual gasotransmitters for inflammatory bowel disease therapy}, volume = {64}, year = {2025}, }
• (2025). Benzamide-directed hydroarylative cross-couplings using minimally activated alkenes: Enantioselective synthesis of tertiary and quaternary stereocenters. ANGEW, 64(22), e202502569. (www)

  @article{ , abstract = {Ir-systems modified with ferrocene-based homochiral diphosphonite ligands, prepared from functionalized SPINOL derivatives, promote benzamide-directed hydroarylative cross-couplings involving minimally activated alkenes. The processes are highly branched selective and enantioselective. Accordingly, tertiary benzylic stereocenters are generated under byproduct-free conditions. This contrast with conventional cross-coupling approaches, which are less step and atom economical. Preliminary results show that the process extends to the formation of quaternary benzylic stereocenters.}, archive = {J_ANGEW}, author = {Timothy P. Aldhous and Raymond Chung and Abbas Hassan and Andrew G. Dalling and Phillippa Cooper and Simon Grélaud and Richard J. Mudd and Lyman J. Feron and Paul D. Kemmitt and John F. Bower}, doi = {10.1002/anie.202502569}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502569}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Benzamide-directed hydroarylative cross-couplings using minimally activated alkenes: Enantioselective synthesis of tertiary and quaternary stereocenters}, volume = {64}, year = {2025}, }
• (2025). Two-dimensional covalent organic frameworks in organic electronics. ANGEW, 64(22), e202502536. (www)

  @article{ , abstract = {Two-dimensional covalent organic frameworks (2DCOFs) are a unique class of crystalline porous materials interconnected by covalent bonds, which have attracted significant attention in recent years due to their chemical and structural diversity, as well as their applications in adsorption, separation, catalysis, and drug delivery. However, research on the electrical properties of 2DCOFs remains limited, despite their potential in organic electronics. Early studies recognized the poor electrical conductivity of 2DCOFs as a significant obstacle to their application in this field. To overcome this challenge, various strategies have been proposed to enhance conductivity. This review first introduces the concept of computational screening for 2DCOFs and explores approaches to improve their intrinsic conductivity, with a focus on four key aspects: in-plane and out-of-plane charge transport, topology, bandgap, and morphology. It then examines the application of pristine 2DCOFs in organic electronics, including applications in field-effect transistors, memristors, photodetectors, and chemiresistive gas sensors. We support these strategies with detailed statistical data, providing a comprehensive guide for the design and development of novel 2DCOFs for organic electronics. Finally, we outline future research directions, emphasizing the challenges that remain to be addressed in this emerging area.}, archive = {J_ANGEW}, author = {Qi Liu and Qiang Li and Yu Li and Taotao Su and Binghan Hou and Yibo Zhao and Youzhi Xu}, doi = {10.1002/anie.202502536}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502536}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-dimensional covalent organic frameworks in organic electronics}, volume = {64}, year = {2025}, }
• (2025). Intervalence charge transfer and exothermic and isoenergetic symmetry breaking charge separation in far-red capturing zinc phthalocyanine dimers. ANGEW, 64(22), e202502516. (www)

  @article{ , abstract = {Orientation and distance-dependent intervalence charge transfer phenomenon is demonstrated in far-red capturing zinc phthalocyanine dimers connected by a bis-acetylene–phenyl π-spacer (ortho, meta, or para positions) upon oxidizing one of the phthalocyanine rings, resulting in split oxidation waves and a new optical transition in the near-infrared region. Optical studies initially probed the symmetry-breaking charge separation events in these dimers wherein solvent polarity-dependent quenching was witnessed. Interestingly, efficient quenching in nonpolar toluene was also seen for the ortho dimer. Free-energy calculations supported symmetry-breaking charge separation in polar solvents and the ortho dimer even in nonpolar solvents under isoenergetic (endothermic by ∼40 mV) conditions. Molecular electrostatic potential maps generated on DFT-optimized structures revealed quadrupolar charge transfer states, more so in polar media. The time-dependent DFT calculations revealed the conversion of the quadrupolar charge transfer states to bipolar charge-separated states from different singlet–singlet excitations. Femtosecond transient absorption studies covering broad temporal and spatial scales provided evidence for the charge separation process, including that for the ortho dimer in toluene, where an isoenergetic process was predicted. The charge-separated states lasted for 200–500 ps depending upon dimer linkage. These unprecedented findings reveal the potential applications of the investigated phthalocyanine dimers in energy harvesting, photocatalytic, and pertinent optoelectronic applications.}, archive = {J_ANGEW}, author = {Ram R. Kaswan and Desiré Molina and Lydia Ferrer-López and Javier Ortiz and Paul A. Karr and Ángela Sastre-Santos and Francis D'Souza}, doi = {10.1002/anie.202502516}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intervalence charge transfer and exothermic and isoenergetic symmetry breaking charge separation in far-red capturing zinc phthalocyanine dimers}, volume = {64}, year = {2025}, }
• (2025). Ultra-low density covalent organic framework sponges with exceptional compression and functional performance. ANGEW, 64(22), e202502513. (www)

  @article{ , abstract = {The emergence of covalent organic frameworks (COFs) macroscopic objects with hierarchical porous structures addresses the limitations of traditional COF powders, which are challenging to process, thus bringing them closer to practical applications. However, the brittleness of the parent COF powder results in poor mechanical stability of these COF macroscopic objects, presenting a significant challenge that must be overcome for their continued development. In this work, we successfully obtained a continuous, hierarchically porous, and interconnected open-cell COF structure made up of hollow sponge walls of thickness 100–250 nm through a template-assisted framework process. This unique structure endows the COF sponge with a high surface area (1655 m 2 g −1 ), ultralow density (2.2 mg cm −3 ), and exceptional mechanical stability. Even after 300 000 compressions at a 50% compression rate, its stress and height decreased by only 7.9% and 7.1%, respectively. These properties grant the COF sponge excellent solvent absorption capacity, catalytic performance, and reusability. Therefore, this work broadens the development pathway for COF macroscopic objects and is expected to further unlock the potential of COFs in practical applications.}, archive = {J_ANGEW}, author = {Chenhui Ding and Yingying Du and Tamara Fischer and Jürgen Senker and Seema Agarwal}, doi = {10.1002/anie.202502513}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502513}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-low density covalent organic framework sponges with exceptional compression and functional performance}, volume = {64}, year = {2025}, }
• (2025). Ti2O3(H2PO4)2·2H2O as a novel intercalated anode for ultralong lifespan “Rocking-chair” aqueous zinc-ion batteries. ANGEW, 64(22), e202502446. (www)

  @article{ , abstract = {The application of aqueous zinc-ion batteries (AZIBs) with Zn metal anode is hindered by severe dendritic growth, corrosion, and inefficient Zn utilization. “Rocking-chair” type AZIBs are considered a viable approach toward practical applications due to the success of commercial lithium-ion batteries employing intercalated graphite anodes. Herein, a new type of layered titanium phosphate Ti 2 O 3 (H 2 PO 4 ) 2 ·2H 2 O is proposed for the first time as the intercalated anodes for AZIBs, exhibiting a capacity of 108 mAh g −1 at 50 mA g −1 , with a low discharge potential of 0.17 V (vs. Zn 2+ /Zn). The ion insertion process is thoroughly investigated, and a micro-dendrite growth-corrosion mode is proposed to explain the capacity degradation mechanism. Corresponding countermeasures are designed, resulting in a significant improvement in cycle life. When coupled with a zinc hexacyanoferrate (KZnHCF) cathode, the “rocking-chair” full battery exhibits an ultralong lifespan of 50000 cycles (111 days) at 2000 mA g −1 with 94% capacity retention. This work presents a novel perspective for the development of practical AZIBs.}, archive = {J_ANGEW}, author = {Xinyu Guo and Chang Li and Yi Zhou and Yan Chen and Wenjun Deng and Rui Li}, doi = {10.1002/anie.202502446}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502446}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ti2O3(H2PO4)2·2H2O as a novel intercalated anode for ultralong lifespan “Rocking-chair” aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Chalcogen-bonding-enabled, light-driven decarboxylative oxygenation of amino acid derivatives and short peptides using o2. ANGEW, 64(22), e202502233. (www)

  @article{ , abstract = {Here we report a photocatalytic method for the decarboxylative oxygenation of amino acid derivatives and short peptides using dioxygen as a green oxidant. A reverse catalytic strategy utilizing Lewis basic diphenyl diselenide as a Lewis acid catalyst to activate carboxylic acid via chalcogen bonding interaction is the key to this work. This synthetic method is tolerant of functionalities present in both natural and non-proteinogenic amino acids, enabling the efficient synthesis of C-terminal amides or imides. Mechanistic studies suggest there is a dual noncovalent interaction between diphenyl diselenide and carboxylic acid, which allows radical decarboxylation through photoinduced intermolecular electron transfer. This new activation mode of carboxylic acids will add a new dimension to classical decarboxylative reactions.}, archive = {J_ANGEW}, author = {Yuzheng Li and Taiqiang Ye and Feng Li and Shenpeng Tan}, doi = {10.1002/anie.202502233}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502233}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chalcogen-bonding-enabled, light-driven decarboxylative oxygenation of amino acid derivatives and short peptides using o2}, volume = {64}, year = {2025}, }
• (2025). Direct quantification of neuroprotective effect of single-atom catalyst on neurochemical transmission by multi-spatiotemporal electrochemistry. ANGEW, 64(22), e202502163. (www)

  @article{ , abstract = {Maintaining redox homeostasis through biocatalytic reactions has emerged as a widely studied neuroprotective strategy for various brain disorders and injuries. However, current research on neuroprotection primarily focuses on functional and behavioral assessments. The impact of neuroprotective interventions on neurotransmission, a critical function of the central nervous system (CNS), remains relatively underexplored. In this study, we report the first direct evidence for neuroprotective effect on neurochemical transmission by multi-spatiotemporal electrochemistry. We employed in vivo and single-vesicle electrochemistry to quantitatively evaluate the neuroprotective effect of an antioxidative Fe single-atom nanozyme (Fe 1 /NC SAzyme) on neurotransmission, using a 1-methyl-4-phenylpyridinium (MPP + )-induced Parkinson's disease (PD) model. In the PD animal model, Fe 1 /NC SAzyme mitigates MPP + neurotoxicity by decreasing damage to dopaminergic neurons, increasing evoked dopamine release, attenuating spontaneous firing, and alleviating locomotor impairment. At the single-cell level, pretreatment with Fe 1 /NC SAzyme inhibits MPP + effects by scavenging reactive oxygen species (ROS), increasing cell viability and ATP concentration, and enhancing the exocytotic release. This study not only provides a research paradigm for directly quantifying therapeutic mechanisms of brain disorders and injury but also reinforces a novel neuroprotective strategy through modulating the redox homeostasis with biocatalytic reactions.}, archive = {J_ANGEW}, author = {Wenjie Ma and Gang Zhao and Ran Liu and Ke Li and Wenjie Wu and Jing Liu and Xiulan He and Lijuan Hou and Ping Yu and Lanqun Mao}, doi = {10.1002/anie.202502163}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502163}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct quantification of neuroprotective effect of single-atom catalyst on neurochemical transmission by multi-spatiotemporal electrochemistry}, volume = {64}, year = {2025}, }
• (2025). Switching products selectivity in electrocatalytic C(sp3)─H bonds activation and CO2 carboxylation via Cu─S bond crystal engineering. ANGEW, 64(22), e202502121. (www)

  @article{ , abstract = {Inert C(sp 3 )─H bonds activation along with CO 2 carboxylation to prepare high-value carboxylic acids is a sustainable route for achieving the carbon-neutral goal, but the current catalytic performance is far from satisfying the demand. Targeting this problem, it was found that crystal engineering of Cu─S bonds not only significantly enhanced the activity of C(sp 3 )─H activation and CO 2 carboxylation in an electrocatalytic system, but also efficiently realized chemoselectivity in the CO 2 carboxylation process. Specifically, hexagonal CuS(001) electrocatalyst could readily achieve C(sp 3 )─H bond activation of alkanes and aromatics along with CO 2 carboxylation, exhibiting almost complete chemoselectivity to carbon chain increased monocarboxylation acids. Intriguingly, hexagonal Cu 2 S(110) electrocatalyst, which was prepared by phase transition, could realize highly selective alkanes and aromatics dicarboxylation with CO 2 to produce dicarboxylation acids. Notably, biomass compound 2-methylfuran was efficiently converted into furan-2-acetic acid over CuS(001); while 2,5-dimethylfuran was quantitatively converted to the degradable polymer precursor furan-2,5-dicarboxylic acid over Cu 2 S(110). Moreover, density functional theory (DFT) results revealed the origin of differences in the activity and chemoselectivity over CuS(001) and Cu 2 S(110) catalysts.}, archive = {J_ANGEW}, author = {Hang Liu and Jia Zeng and Denghong Zhao and Mingwei Yang and Long Qin and Hongji Chen and Xue Gao and Zhongyi Yin and Rui Wang and Heyan Jiang}, doi = {10.1002/anie.202502121}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502121}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switching products selectivity in electrocatalytic C(sp3)─H bonds activation and CO2 carboxylation via Cu─S bond crystal engineering}, volume = {64}, year = {2025}, }
• (2025). Hydrogen bond boosts circularly polarized radioluminescence in chiral Mn(II) hybrids. ANGEW, 64(22), e202502099. (www)

  @article{ , abstract = {Chiral scintillators combining scintillation and circularly polarized luminescence (CPL) present a novel avenue for controlling light propagation and reducing optical crosstalk in conventional scintillators. However, quantitative evaluation of circularly polarized radioluminescence (CPRL) and strategies for enhancing performance under X-ray excitation remain underexplored. Herein, we conducted the designed synthesis of Mn(II) hybrid enantiomers, (1 R / S ,2 R / S )-( N , N , N ′, N ′-tetramethyl-1,2-cyclohexanediamine) 2 MnBr 4 ·2Br − ( R / S -1 ), which exhibit intense CPL with photoluminescence (PL) quantum yields of 94.4% ( R -1 ) and 94.1% ( S -1 ) and PL dissymmetry factors ( g PL ) of −3.87 × 10 −3 ( R -1 ) and + 3.98 × 10 −3 ( S -1 ). They demonstrate strong scintillation performance with record-breaking light yields of 70 061 and 68 514 photons/MeV in chiral scintillators. We pioneered quantitative evaluation of the CPRL of R / S -1 , achieving radioluminescence (RL) dissymmetry factors ( g RL ) of −2.04 × 10 −3 and + 2.55 × 10 −3 . By incorporating hydrogen bonds into the structures through rational ligand design to facilitate chiral transfer, Mn(II) hybrid enantiomers (1 R / S ,2 R / S )-( N , N ′-dimethyl-1,2-cyclohexanediamine)MnBr 4 ( R / S -2 ) achieve the g PL values of −2.56 × 10 −2 and + 2.50 × 10 −2 with nearly seven times higher than those of R/S -1 . More inspiringly, the g RL value of R -2 increased to −2.96 × 10 −2 with a 15 times increase relative to R -1 , representing the highest CPRL in lead-free chiral scintillators. This work not only manifests a new design strategy for advancing chiral scintillators but also establishes a standard approach for evaluating CPRL properties.}, archive = {J_ANGEW}, author = {Jia-Yu Yao and Qing-Rong Ding and Hao Zeng and Jin-Yun Wang and Cui-Mi Shi and Liang-Jin Xu and Zhong-Ning Chen}, doi = {10.1002/anie.202502099}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502099}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen bond boosts circularly polarized radioluminescence in chiral Mn(II) hybrids}, volume = {64}, year = {2025}, }
• (2025). Unraveling electrode surface chemistry in determining interphase stability and deposition homogeneity for anode-free potassium metal batteries. ANGEW, 64(22), e202502091. (www)

  @article{ , abstract = {Potassium metal batteries with an anode-less/-free configuration could realize competitive energy density, which requires exceptional potassium plating/stripping reversibility via guiding smooth potassium growth and building mechanically stable solid electrolyte interphase (SEI). Electrolyte engineering has been the most widely adopted strategy, but there is less understanding of the electrode effect. We demonstrate that the extent of electrolyte decomposition could also be regulated through electrode surface modification. Elevating the work function of an Al current collector by coating a thin layer of Ni-decorated carbon nanofiber could greatly suppress the copious solvent reduction, leading to the formation of inorganic-rich SEIs. Such SEIs possess a large elastic deformation energy to accommodate the volume change and a high ionic conductivity to boost the reaction kinetics. Moreover, the potassiophilic nickel species offer abundant active sites to induce homogeneous potassium deposition. Benefiting from the synergy of stable interphases and promoted nucleation, the modified Al enables a 4.4 V anode-free cell in a normal-concentration electrolyte without anode precycling.}, archive = {J_ANGEW}, author = {Zhenlu Yu and Qun Liu and Danni Wang and Jie Shi and Dengyun Zhai and Biao Zhang}, doi = {10.1002/anie.202502091}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502091}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling electrode surface chemistry in determining interphase stability and deposition homogeneity for anode-free potassium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Engineering proton-coupled electron transfer to break activity-stability trade-off of oxygen electroreduction catalysts for temperature-adaptive Zn–Air battery. ANGEW, 64(22), e202502019. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) are regarded as effective electrocatalysts for oxygen reduction reaction (ORR). However, integrating high active and long-term durability on SACs is still challenging due to the severe limitations of the activity-stability trade-off. Herein, we report an integrative electrocatalyst combining isolated Fe sites and MoC nanoparticles (MoC/Fe─NC). MoC nanoparticles accelerate ORR kinetics via the proton-feeding effect and optimize Fe site microstructure. Thus, MoC/Fe─NC exhibits a high alkaline ORR activity with half-wave potential ( E 1/2 ) of 0.916 V versus the reversible hydrogen electrode, and exceptional durability of 50k cycles with 5 mV E 1/2 loss. The observed ORR performance is further verified in a zinc–air battery (ZAB) with a high peak power density of 316 mW cm −2 and operational stability over 1000 h. Moreover, the fabricated temperature-adaptive quasi-solid-state ZAB can cycle stably for 150 h under alternating temperatures. Theoretical calculations and experiment characterizations, involving scanning electrochemical microscopy techniques and distribution of relaxation times analysis, reveal that the excellent capabilities of MoC/Fe─NC arise from accelerated proton-coupled electron transfer, weakened *OH adsorption, and strengthened Fe─N bonds fueled by MoC nanoparticles. This work sheds light on breaking the activity-stability trade-off barrier of SACs for energy-conversion applications.}, archive = {J_ANGEW}, author = {Yonggan Wu and Yuqin Zhang and Liansheng Lan and Ting Hu and Shaobin Tang and Dirk Lützenkirchen-Hecht and Kai Yuan and Yiwang Chen}, doi = {10.1002/anie.202502019}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202502019}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering proton-coupled electron transfer to break activity-stability trade-off of oxygen electroreduction catalysts for temperature-adaptive Zn–Air battery}, volume = {64}, year = {2025}, }
• (2025). Atroposelective construction of C─B axial chirality via N-heterocyclic carbene-catalyzed dynamic kinetic resolution. ANGEW, 64(22), e202501991. (www)

  @article{ , abstract = {C─B axially chiral architectures are valuable in materials science and medicinal chemistry, but their enantioselective synthesis remains a challenge. Herein, we report an efficient method for the enantioselective synthesis of C─B axially chiral 1,2-azaborines through N-heterocyclic carbene-catalyzed dynamic kinetic resolution. The treatment of racemic 1,2-azaborine-based arylaldehyde with a chiral N-heterocyclic carbene catalyst under oxidative conditions in the presence of an alcohol leads to atroposelective esterification with up to 97% yield and 98% ee. The practicality of this method has been demonstrated by the late-stage functionalization, gram-scale synthesis, and further synthetic transformations. Mechanistic studies indicate that the chiral N-heterocyclic carbene catalyst differentiates between rapidly equilibrating atropoisomeric 1,2-azaborine-based arylaldehyde. DFT studies suggest that the formation of the Breslow intermediate via [Cs]HCO 3 -assisted [1,2]-proton transfer is the enantioselectivity-determining step.}, archive = {J_ANGEW}, author = {Ying Huang and Xue-Ning Li and Xin-Han Wang and Zhi-Xiang Wang and Song Ye and Chun-Lin Zhang}, doi = {10.1002/anie.202501991}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501991}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atroposelective construction of C─B axial chirality via N-heterocyclic carbene-catalyzed dynamic kinetic resolution}, volume = {64}, year = {2025}, }
• (2025). Conversion of bestmann ylide into carbophosphinocarbene. ANGEW, 64(22), e202501955. (www)

  @article{ , abstract = {The ortho -carboranyl carbophosphinocarbene (CPC) has been synthesized through a click-type reaction between the super strained carborane-fused borirane 1,2-BN(SiMe 3 ) 2 –1,2-C 2 B 10 H 10 and Bestmann ylide Ph 3 PCCO. The [Cl(CO)₂Ir-CPC] and [Cl 3 Ga-CPC] complexes were synthesized, allowing the measurement of their Tolman electronic parameter (TEP) and the sum of Cl─Ga─Cl bond angles (∑ClGaCl), respectively. These data highlight their remarkable electron-donating ability. Further insights into its electron-donating properties were gained through theoretical calculations, including analysis of frontier orbitals and proton affinity (PA). Preliminary reactivity investigations demonstrate that the new CPC readily forms adducts with boranes and can effectively stabilize borenium cations. Its strong nucleophilicity enables reactions with carbon dioxide, while its exceptional Brønsted basicity allows it to deprotonate imidazolium to generate carbene species.}, archive = {J_ANGEW}, author = {Libo Xiang and Junyi Wang and Niclas Knoblauch and Alexander Matler and Qing Ye}, doi = {10.1002/anie.202501955}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501955}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conversion of bestmann ylide into carbophosphinocarbene}, volume = {64}, year = {2025}, }
• (2025). Azobenzene-oxindole photochromic dyads. ANGEW, 64(22), e202501872. (www)

  @article{ , abstract = {Manipulation of molecular geometry using photoresponsive units is a powerful tool in supramolecular chemistry, smart materials, and photopharmacology. Current synthetic chemistry offers many responsive molecules that perform such a task. However, the incorporation of various photoresponsive units in a single molecule to achieve several geometrical changes remains scarce, particularly when they are in close proximity. The development of such systems is limited by challenges arising from selectively addressing the photoresponsive moieties and the analysis of complex mixtures. Here, we overcome these challenges by constructing a novel hetero-photochromic azobenzene-oxindole dyad (AOD). Both chromophores can be addressed and quantified in solution by in situ NMR irradiation analysis. Additionally, this method allows us to unravel the intricate photokinetic relationships between the two chromophores, leading to the observation of an unprecedented molecular motion: an azobenzene E → Z → E isomerization at a single wavelength due to the oxindole influence. By functionalizing the azobenzene ring, we showed that the responsiveness of the system is maintained in seven distinct AODs. Overall, the photochromic dyad offers dramatic geometrical changes over its four isomers, making it a useful tool for further applications in which such behavior is desired, such as host-guest systems, responsive materials, photopharmacology, and molecular machines.}, archive = {J_ANGEW}, author = {Marco Ovalle and Daniel Doellerer and Ben L. Feringa}, doi = {10.1002/anie.202501872}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Azobenzene-oxindole photochromic dyads}, volume = {64}, year = {2025}, }
• (2025). Leveraging noncovalent interactions for the binding of CO by a weakly lewis acidic borane. ANGEW, 64(22), e202501774. (www)

  @article{ , abstract = {Known boron carbonyl complexes either exploit very high Lewis acidity or a low oxidation state boron centre in order to capture CO. By contrast, we report a carbonyl complex featuring a simple tri-coordinate borane, characterized by a Lewis acidity which is only marginally higher than B(NMe 2 ) 3 . {(Ph 2 P)xanth} 3 B features a solid-state structure in which two of the three B-bound xanth(PPh 2 ) units are projected above the BC 3 plane, generating an up , up , down conformation. Quantum chemical methods, however, reveal that the alternative up , up , up alignment, characterized by a cage-like geometry and enhanced intramolecular noncovalent interactions, is favored significantly in silico (by ca. 33.0 kcal mol −1 ). Although this conformation is optimal for binding polar C 3 -symmetric H-bond donors such as NH 3 (and related guests such as H 2 O and MeNH 2 ) the binding of essentially nonpolar substrates such as CO would be expected to be weak at best. However, exposure of {(Ph 2 P)xanth} 3 B to CO under mild conditions (1 bar, 25 °C) reversibly yields {(Ph 2 P)xanth} 3 B·CO, a tractable cage-like borane carbonyl adduct featuring a central BCO moiety shrouded by xanth(PPh 2 ) moieties. Dispersion forces are critical to substrate binding: the two binding modes in which the B-bound CO guest is located inside/outside the host cage differ in energy by 59.5 kcal mol −1 .}, archive = {J_ANGEW}, author = {Agamemnon E. Crumpton and Caitilín McManus and Simon Aldridge}, doi = {10.1002/anie.202501774}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501774}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging noncovalent interactions for the binding of CO by a weakly lewis acidic borane}, volume = {64}, year = {2025}, }
• (2025). Multi-dimensional Ni@TiN/CNT heterostructure with tandem catalysis for efficient electrochemical nitrite reduction to ammonia. ANGEW, 64(22), e202501578. (www)

  @article{ , abstract = {Electrochemical nitrite reduction reaction (NO 2 RR) is considered a sustainable ammonia (NH 3 ) synthesis strategy. However, there are still significant challenges in designing efficient NO 2 RR catalysts. Here, carbon nanotube (CNT)-encapsulated Ni nanoparticles (NPs) loaded on MXene-derived TiN (Ni@TiN/CNT) heterostructure is constructed by combining molten salt etching strategy and chemical vapor deposition. Ni@TiN/CNT exhibits an excellent NH 3 yield rate (15.6 mg h −1 mg cat. −1 ), Faradaic efficiency (95.6%), and record cycle stability (NO 2 RR performance is virtually unattenuated after 60 cycles) at −0.7 V versus reversible hydrogen electrode (versus RHE). In addition, the Zn-nitrite battery with Ni@TiN/CNT as the cathode shows high power density (9.6 mW cm −2 ) and NH 3 synthesis performance. Combining validation experiments and density functional theory calculations reveals that Ni@TiN/CNT follows the tandem catalytic mechanism. The TiN site preferentially adsorbs and activates NO 2 − , while the Ni site provides abundant active hydrogen for the subsequent reduction process. Meanwhile, the chainmail structure of CNT prevents the oxidation and leaching of active sites, thereby significantly enhancing the stability of Ni@TiN/CNT. This work provides a new inspiration for the preparation of durable and efficient NO 2 RR electrocatalysts with tandem catalytic sites.}, archive = {J_ANGEW}, author = {Zhijie Cui and Pengwei Zhao and Honghai Wang and Chunli Li and Wenchao Peng and Jiapeng Liu}, doi = {10.1002/anie.202501578}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-dimensional Ni@TiN/CNT heterostructure with tandem catalysis for efficient electrochemical nitrite reduction to ammonia}, volume = {64}, year = {2025}, }
• (2025). Electrolyte effects in membrane-electrode-assembly CO electrolysis. ANGEW, 64(22), e202501505. (www)

  @article{ , abstract = {Membrane-electrode-assembly (MEA)-based CO electrolysis (COE) has demonstrated the capability to produce C 2+ products with high faradaic efficiency at ampere-level current densities. However, most studies on COE have achieved performance benchmarks under strongly alkaline conditions (e.g., ≥1 m KOH, pH ≥14), raising the question of whether such high pH levels are essential for optimal performance. In this study, we investigated the effects of different electrolytes (KHCO 3 , K 2 CO 3 , and KOH) on MEA-based CO electrolysis, focusing on the influence of pH and the impact of anodic oxidation on the selectivity of various liquid products. By adjusting electrolyte concentration and pH, we achieved significant partial current densities for ethanol (189 ± 5 mA cm −2 ) and propanol (89 ± 4 mA cm −2 ) using 0.5 M K 2 CO 3 . This high performance is attributed to the creation of a moderate local alkaline environment and the relatively high resistance to anodic oxidation. Additionally, durability measurements emphasized the critical importance of eliminating anodic oxidation to optimize MEA-based COE for ethanol and propanol production.}, archive = {J_ANGEW}, author = {Qiucheng Xu and Bjørt Óladóttir Joensen and Nishithan C. Kani and Andrea Sartori and Terry Willson and John R. Varcoe and Luca Riillo and Anna Ramunni and Jakub Drnec and Ib Chorkendorff and Brian Seger}, doi = {10.1002/anie.202501505}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501505}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte effects in membrane-electrode-assembly CO electrolysis}, volume = {64}, year = {2025}, }
• (2025). Propylene-bridged associative bis(bipyridinium) electrolytes for long-lifetime aqueous organic redox flow batteries. ANGEW, 64(22), e202501458. (www)

  @article{ , abstract = {Aqueous organic redox flow batteries (AORFBs) represent a potent technology in low-cost storage and grid-scale adoption of renewable electricity, whereas bipyridinium derivatives, the most extensively adopted anolyte, undergo diverse side reactions causing severe loss of battery lifetime. Here, we propose a strategy to promote the formation of intramolecular radical π dimers of reduced bipyridinium electrolytes and stabilize the radical intermediates during charge and discharge, resulting in significant improvements in battery lifetime. Density functional theory calculations reveal that proof-of-concept electrolytes, M-bisV and TMAP-bisV, demonstrate Gibbs free energy change of −101.49 kJ mol −1 and −103.90 kJ mol −1 for the formation of radical π dimers, as opposed to the less favored −14.36 kJ mol −1 for methyl viologen. Electron paramagnetic resonance and UV–vis spectra studies confirmed the significantly facilitated intramolecular π–π stacking of M-bisV and TMAP-bisV radicals. This translates to a more than one order of magnitude improvement in electrolyte stability for M-bisV and TMAP-bisV in flow cells. Specifically, TMAP-bisV possesses a theoretical capacity of 66.5 Ah L −1 and exhibits negligible capacity fade at 1.5 M e − , which represents a new record in this area. We believe the concept may open a promising avenue toward the design of capacity-dense and super-stable AORFB electrolytes.}, archive = {J_ANGEW}, author = {Gonggen Tang and Kang Peng and Yahua Liu and Junkai Fang and Wenyi Wu and Zhengjin Yang and Tongwen Xu}, doi = {10.1002/anie.202501458}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501458}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Propylene-bridged associative bis(bipyridinium) electrolytes for long-lifetime aqueous organic redox flow batteries}, volume = {64}, year = {2025}, }
• (2025). Semiconductor spacer with donor-acceptor structure drives 2D Ruddlesden–Popper perovskite solar cells beyond 20% efficiency. ANGEW, 64(22), e202501210. (www)

  @article{ , abstract = {Two dimensional (2D) Ruddlesden–Popper (RP) perovskites have emerged as promising photovoltaic materials. However, their further improvement in photovoltaic efficiency is hindered by the large dielectric mismatch and high exciton binding energy caused by the insulating spacers. Herein, two semiconductor spacers, namely MeBThMA and CNBThMA, were developed for 2D RP perovskite solar cells (PSCs). In contrast to MeBThMA, the CNBThMA spacer, which features a donor-acceptor (D-A) structure, exhibits a larger dipole moment and adopts a face-to-face molecular stacking arrangement in the single crystal. The unique D-A structure effectively eliminates the dielectric mismatch between the organic and inorganic layers, contributing the formation of energy levels, adjusting the anisotropic charge transport properties, and improving the film quality of layered RP perovskites. Consequently, the devices based on CNBThMA (nominal n = 5) achieved a champion efficiency of 20.82%, which is a record efficiency for 2D RP PSCs using semiconductor spacers to the best of our knowledge. Our work pioneers a novel way to design organic semiconductor spacers using a D-A structure for highly efficient 2D PSCs.}, archive = {J_ANGEW}, author = {Xiyue Dong and Hao Zhang and Jiangnan Li and Liu Yang and Yuting Ma and Hang Liu and Ziyang Hu and Yongsheng Liu}, doi = {10.1002/anie.202501210}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501210}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Semiconductor spacer with donor-acceptor structure drives 2D Ruddlesden–Popper perovskite solar cells beyond 20% efficiency}, volume = {64}, year = {2025}, }
• (2025). Direct observation of cyclo-pentazolate anion decomposition in a tailored molecular trap. ANGEW, 64(22), e202501187. (www)

  @article{ , abstract = {The cyclo -pentazolate anion ( cyclo -N 5 − ) has garnered significant attention as an all-nitrogen, five-membered-ring ion with a high energy state and unique aromaticity. Typically, the free cyclo -N 5 − anion is a highly unstable species, and its stabilization relies on strong interactions, such as a hydrogen bonding network or metal coordination. However, these interactions often compromise the independence of the anion, thus diminishing its aromaticity. Herein, we present a molecular trap designed to encapsulate and isolate cyclo -N 5 − through collective weak interactions. This approach utilizes a pre-positioned ion to subsequently displace the cyclo -N 5 − anion into the cage cavity, addressing the challenge posed by the absence of strong-interaction-driven binding. This setup preserves the aromaticity of the anion to a significant extent, as predicted by computational studies. More importantly, the decomposition of free cyclo -N 5 − within the microenvironment was directly recorded for the first time using single-crystal X-ray diffraction analysis.}, archive = {J_ANGEW}, author = {Jinjin Zhang and Mingjie Tang and Siyuan Yang and Hongqing Li and Guangbin Cheng and Yongxing Tang and Ming Liu}, doi = {10.1002/anie.202501187}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501187}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct observation of cyclo-pentazolate anion decomposition in a tailored molecular trap}, volume = {64}, year = {2025}, }
• (2025). Ethylene pretreatment enhances ethylene adsorption and separation over Cu@SAPO-RHO zeolite. ANGEW, 64(22), e202501053. (www)

  @article{ , abstract = {Efficient ethylene/ethane (C 2 H 4 /C 2 H 6 ) separation using low-energy technologies is crucial for the chemical industry yet remains challenging due to the lack of industrially applicable adsorbents. Cu(I)-based adsorbents show significant potential; however, traditional synthesis methods often involve complex procedures or reduction steps. Herein, we report that Cu@SAPO-RHO zeolite, synthesized for the first time via a one-pot method with cyclam as the Cu(II) ligand, exhibits a remarkable C 2 H 4 /C 2 H 6 selectivity of 22.6, a C 2 H 4 uptake of 3.08 mmol g −1 , and a separation factor of 9.4 under ambient conditions by using a C 2 H 4 pretreatment, placing it among the best-performing zeolitic materials. The C 2 H 4 pretreatment enhances separation efficiency by partially reducing Cu(II) to Cu(I) and water resistance through the formation of carbon species during pretreatment. Structural analysis using Rietveld refinement reveals that Cu 2+ ions occupy the corners of elliptical single 8-rings ( s 8 r ). X-ray absorption near-edge structure analysis confirms a reduction in the Cu oxidation state, while X-ray photoelectron spectroscopy corroborates the partial conversion of Cu(II) to Cu(I). Periodic density functional theory calculations further reveal that Cu(I) interacts more strongly with C 2 H 4 than Cu(II). With its straightforward synthesis and enhanced performance through C 2 H 4 pretreatment, Cu@SAPO-RHO zeolite presents a promising solution for industrial-scale C 2 H 4 /C 2 H 6 separation.}, archive = {J_ANGEW}, author = {Ruobing Bai and Nana Yan and Guangyuan He and Yingchun Ye and Risheng Bai and Dan Li and Peng Guo and Donghai Mei and Wenfu Yan and Jihong Yu}, doi = {10.1002/anie.202501053}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501053}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ethylene pretreatment enhances ethylene adsorption and separation over Cu@SAPO-RHO zeolite}, volume = {64}, year = {2025}, }
• (2025). Cation-in-mesopore complex for 20 ah-level aqueous battery. ANGEW, 64(22), e202501010. (www)

  @article{ , abstract = {Metallic Zn-based aqueous batteries (ZABs) have arisen as one of the most promising safe energy storage solutions, yet practical development, especially for the Ah-level ZABs, is severely plagued by unmanageable side reactions and notorious dendrite proliferation. Here, we propose a cation-in-mesopore (CiM) complex chemistry by confining Zn 2+ within single-mesopore cavities to construct a novel paradigm of 20 Ah-level ZABs. Molecule dynamic and X-ray absorption near-edge structure analyses reveal that the single-mesopore SiO 2 (smSiO 2 ) traps Zn 2+ , replacing H 2 O molecules in the primary sheath and forming Zn 2+ –smSiO 2 complexes. In situ electrochemical digital holography, in situ interface Fourier-transform infrared spectroscopy, and H-bonds density analyses clearly confirm that Zn 2+ –smSiO 2 complexes migrate and adhere onto the metallic Zn, facilitating the formation of mesopore weak H-bonds interface by disrupting the aggregation of solvated H 2 O. Consequently, the Zn anode operates over 800 h under 55% depth of discharge, effectively suppressing H 2 O degradation and dendrite growth. The Zn//VO 2 pouch battery demonstrates capacities of 20.5 Ah at 0.2 A g −1 and 8.59 Ah at 1 A g −1 , and energy density of 65 Wh kg −1 and 96 Wh L −1 . The proposed cation-in-mesopore complex chemistry may mark a substantial step forward towards more sustainable and reliable ZABs.}, archive = {J_ANGEW}, author = {Lipeng Wang and Bao Zhang and Wanhai Zhou and Hongpeng Li and Haobo Dong and Hongrun Jin and Zefang Yang and Wei Li and Zaiwang Zhao and Dongyuan Zhao and Dongliang Chao}, doi = {10.1002/anie.202501010}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202501010}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cation-in-mesopore complex for 20 ah-level aqueous battery}, volume = {64}, year = {2025}, }
• (2025). Constructing Mechanical–Chemical stability via multiphase riveting and interface optimization toward layer-structured oxide cathode material. ANGEW, 64(22), e202500939. (www)

  @article{ , abstract = {Manganese-based layer-structured oxide materials are considered as one of the most competitive cathode materials for sodium-ion batteries due to their low cost and efficient sodium intercalation chemistry. Their electrochemical performance, however, is hindered by mechanical and chemical failures stemming from weak interlayer interactions, the Jahn–Teller effect of Mn 3+ and unstable surfaces. To address these issues, a quenching method was employed to fabricate a robust multiphase structure with a fluorine and dislocation-rich surface. Through the accumulation of dislocations and the interlocking of multiphase structures, the mechanical stability of the material during (de)sodiation processes is enhanced, while the surface fluorine anchoring further strengthens the chemical stability. Even after 200 cycles at 0.5 C and 1 C within the voltage range of 1.5–4.5 V, the designed composite material P2/P3/O3-Na 0.89 Ni 0.3 Mn 0.55 Cu 0.1 Ti 0.05 O 1.94 F 0.06 exhibits impressive capacity retention rates of 87.17% and 90.4%, respectively. This work exemplifies the important role of simultaneous design of mechano-chemically coupled materials for the development of high performances cathode materials.}, archive = {J_ANGEW}, author = {Dongrun Yang and Chen Liu and Xuan-Wen Gao and Zhiwei Zhao and Qinfen Gu and Yutong Long and Qingsong Lai and Hong Chen and Zhaomeng Liu and Wen-Bin Luo}, doi = {10.1002/anie.202500939}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500939}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing Mechanical–Chemical stability via multiphase riveting and interface optimization toward layer-structured oxide cathode material}, volume = {64}, year = {2025}, }
• (2025). Low-coordination triangular cu3 motif steers CO2 photoreduction to ethanol. ANGEW, 64(22), e202500928. (www)

  @article{ , abstract = {Photoreduction of CO 2 using copper-based multi-atom catalysts (MACs) offers a potential approach to achieve value-added C 2+ products. However, achieving MACs with high metal contents and suppressing the thermodynamically favored competing ethylene production pathway remain challenging, thus leading to unsatisfactory performance in ethanol production. Herein, we developed a “pre-locking and nanoconfined polymerization” strategy for synthesis of an ultra-high-density Cu MAC with low-coordination triangular Cu 3 motifs (Cu 3 MAC) on polymeric carbon nitride mesoporous nanofibers. The Cu 3 MAC with Cu contents of 36 wt% achieves a high reactivity of 117 µmol g −1 h −1 for ethanol production from CO 2 and H 2 O, with a remarkable selectivity of 98% under simulated sunlight irradiation, representing one of the highest performances in ambient conditions without sacrificial reagents. The superior catalytic efficiency is attributed to the triangular Cu 3 configuration, in which both Cu(I) and Cu(II) coexist, predominantly as Cu(I). Such Cu 3 motifs act as strong alkaline sites that effectively chemisorb and activate CO 2 , extend visible-light absorption range, while accumulating high-density electrons and favoring 12-electron-transfer products. An accelerated asymmetric C─C coupling with adsorption configuration of the bridge-adsorbed *CO at paired Cu sites and atop-adsorbed *CO at adjacent single Cu atom was observed, enabling preferential formation of *CHCHOH intermediates to produce ethanol.}, archive = {J_ANGEW}, author = {Huining Wang and Lu Song and Ximeng Lv and Haozhen Wang and Fan Zhang and Shuya Hao and Ruilin Wei and Lijuan Zhang and Qing Han and Gengfeng Zheng}, doi = {10.1002/anie.202500928}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500928}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-coordination triangular cu3 motif steers CO2 photoreduction to ethanol}, volume = {64}, year = {2025}, }
• (2025). Engineering an excellent β-BaB2O4-inspired UV nonlinear optical material through secondary building unit substitution. ANGEW, 64(22), e202500877. (www)

  @article{ , abstract = {The development of nonlinear optical (NLO) crystals with tailored properties has been a long-standing pursuit, yet remains challenging to achieve. Herein, we report the successful synthesis of a novel high-performance UV NLO material, Li 3 [Be 3 (OH) 3 (C 3 H 2 O 4 ) 3 ]·7H 2 O (LBOC), by substituting the [B 3 O 6 ] functional building units (FBUs) in the classic β -BaB 2 O 4 ( β -BBO) with meticulously designed [Be 3 (OH) 3 (C 3 H 2 O 4 ) 3 ] 3− secondary building units (SBUs). The [Be 3 (OH) 3 (C 3 H 2 O 4 ) 3 ] 3− SBUs within LBOC preserve the ordered arrangement of the [B 3 O 6 ] FBUs found in β -BBO, enabling LBOC to inherit the strong second harmonic generation (SHG) response from β -BBO. Additionally, the increased dimensionality of the [Be 3 (OH) 3 (C 3 H 2 O 4 ) 3 ] 3− SBUs, compared to the planar [B 3 O 6 ] FBUs, leads to a reduction in optical anisotropy. Consequently, LBOC demonstrates a moderate birefringence of 0.067@589.3 nm, lower than that of β -BBO (0.118@589.3 nm). Notably, bulk crystals of LBOC can be easily grown using a straightforward solution evaporation method, making it a promising candidate for UV NLO applications. This strategic design of the SBU opens new avenues for the rational development of NLO crystals with tailored properties.}, archive = {J_ANGEW}, author = {Lingli Wu and Chensheng Lin and Haotian Tian and Tao Yan and Bing-Xuan Li and Huixin Fan and Yujie Fan and Shunda Yang and Min Luo}, doi = {10.1002/anie.202500877}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500877}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering an excellent β-BaB2O4-inspired UV nonlinear optical material through secondary building unit substitution}, volume = {64}, year = {2025}, }
• (2025). Fluorophores nucleate and stabilize collagen triple helices – En route to better diagnostic tools for fibrosis and tissue repair. ANGEW, 64(22), e202500856. (www)

  @article{ , abstract = {Fluorescently labeled collagen model peptides (CMPs) are useful tools for monitoring fibrotic processes and tissue repair. Fine-tuning the propensity of the CMP to form a collagen triple helix is crucial since only single-stranded but not triple-helical CMPs integrate efficiently into damaged or remodeling tissue. Yet the impact of fluorophores on the folding behavior of CMPs and triple helix stability has so far been underappreciated. Here, we show that N-terminal fluorophores enhance triple helix stability and nucleation. Thermal denaturation and temperature jump experiments showed that triple helix stability and nucleation are proportionally affected by the accessible surface area of the fluorophore. For biological applications, fluorophores with a small surface area are therefore beneficial. Furthermore, we show that fluorophores bearing ionizable groups with an appropriate p K a value, such as commonly used fluorescein, can be used to create pH-responsive assemblies. Our findings highlight the importance of carefully selecting appropriate fluorophores and spacers when developing fluorescent probes for biological applications.}, archive = {J_ANGEW}, author = {Linus B. Boll and Leonard W. Kreft and Helma Wennemers}, doi = {10.1002/anie.202500856}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500856}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorophores nucleate and stabilize collagen triple helices – En route to better diagnostic tools for fibrosis and tissue repair}, volume = {64}, year = {2025}, }
• (2025). Molecular engineering of a self-sustaining modular afterglow scaffold for in vivo activatable imaging. ANGEW, 64(22), e202500801. (www)

  @article{ , abstract = {Self-sustaining afterglow molecules (SAMs) offer high simplicity, reproducibility, and design flexibility compared to common multicomponent systems. To date, only a few SAMs have been reported. However, these studies mainly focus on probe selection and screening, without providing the guidance for constructing SAMs from the bottom up. Herein, we report the molecular design and tuning of a boron dipyrromethene derivative (BDI), with structural engineering to enhance the singlet oxygen ( 1 O 2 ) reactivity and photosensitivity, aiming to construct SAMs for activatable afterglow imaging. The optimized BDI is customized into water-soluble nanoparticles (i.e., BDI-NPs) aided by an amphiphilic polymer, achieving all-in-one afterglow luminescence with a peak at 780 nm. An activatable afterglow probe (i.e., BDIS-NPs) is fabricated, which can simultaneously activate fluorescence and afterglow signals in the presence of hydrogen disulfide (H 2 S). Owing to the elimination of autofluorescence and high activation contrast of the afterglow signal, BDIS-NPs enables early monitoring of lipopolysaccharide (LPS)-induced acute lung injury within 15 min and sensitive visualization of H 2 S accumulation in the brain of schizophrenia mice with a high signal-to-background ratio (SBR), which is not achievable by fluorescence imaging. This study provides an in-depth understanding and design guidelines for SAMs and activatable afterglow imaging.}, archive = {J_ANGEW}, author = {Yuyang Zhang and Weina Xu and Diedie Cheng and Meng Zhao and Jiamin Xiong and Qing Li and Qingqing Miao}, doi = {10.1002/anie.202500801}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500801}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular engineering of a self-sustaining modular afterglow scaffold for in vivo activatable imaging}, volume = {64}, year = {2025}, }
• (2025). Li21Ge8P3S34: New lithium superionic conductor with unprecedented structural type. ANGEW, 64(22), e202500732. (www)

  @article{ , abstract = {Lithium superionic conductors are pivotal for enabling all-solid-state batteries, which aim to replace liquid electrolytes and enhance safety. Herein, we report the discovery of an unprecedented lithium superionic conductor, Li 21 Ge 8 P 3 S 34 , featuring a novel structural type and a new composition in the Li–Ge–P–S system. This material exhibits high lithium ionic conductivity of approximately 1.0 mS cm −1 at 303 K with a low activation energy of 0.20(1) eV. It's unique crystal structure was elucidated using three-dimensional electron diffraction (3D ED) and further refined through combined powder X-ray and neutron diffraction analyses. The structure consists of alternating two-dimensional slabs: one of corner-sharing GeS 4 tetrahedra and the other of isolated PS 4 tetrahedra, enabling efficient lithium-ion transport through a tetrahedrally interconnected network of 1D, 2D, and 3D diffusion pathways. This distinctive structural motif provides a novel design strategy for next-generation solid electrolytes, broadening the structural landscape of lithium superionic conductors. With further advancements in compositional tuning and interfacial engineering, Li 21 Ge 8 P 3 S 34 could contribute to the development of high-performance all-solid-state batteries.}, archive = {J_ANGEW}, author = {Jihun Roh and Saleh Gholam and Namgyu Do and Alicia Manjón-Sanz and Joke Hadermann and Seung-Tae Hong}, doi = {10.1002/anie.202500732}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500732}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Li21Ge8P3S34: New lithium superionic conductor with unprecedented structural type}, volume = {64}, year = {2025}, }
• (2025). Cobaloxime-based metalloradical catalysis: A versatile strategy for the synthesis of cyclopropenes and oxazoles. ANGEW, 64(22), e202500667. (www)

  @article{ , abstract = {Metalloradical catalysis (MRC), predominantly exemplified by metalloporphyrin complexes, has emerged as a promising strategy for regulating radical reactions and broadening their synthetic applications. Here, an efficient catalytic method has been devised for the radical [2 + 1] cyclopropenation of alkynes and radical [3 + 2] oxazolation of nitriles using α-aryldiazoacetates via MRC. Cobaloxime proves effective in facilitating the metalloradical [2 + 1] cyclopropenation of alkynes and radical [3 + 2] oxazolation cycloaddition reaction under mild conditions. The reactions demonstrate broad substrate tolerance, accommodating gram-scale transformations and the synthesis of pharmaceutical compounds. Our findings highlight the significant potential of cobaloxime-catalyzed cycloaddition as a valuable tool in organic synthesis and broaden the scope of metalloradical systems in catalysis.}, archive = {J_ANGEW}, author = {Liming Tan and Keyang Wu and Gang Li}, doi = {10.1002/anie.202500667}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobaloxime-based metalloradical catalysis: A versatile strategy for the synthesis of cyclopropenes and oxazoles}, volume = {64}, year = {2025}, }
• (2025). Spatially controlled co-delivery of diagnostic and therapeutic agents using DNA nanoframeworks for pancreatic cancer precision therapy. ANGEW, 64(22), e202500566. (www)

  @article{ , abstract = {Theranostic platforms that integrate diagnostic and therapeutic functionalities offer promising strategies for precision medicine, particularly in the treatment of major diseases. However, the development of platforms capable of achieving spatially controlled detection and therapy at the lesion site remains a significant challenge. Herein, we present a dual-stimuli-responsive DNA nanoframework that achieve spatially controlled codelivery of molecular beacon (MB) and Cas9 ribonucleoprotein (RNP), enabling simultaneous specific optical detection and efficient gene therapy for pancreatic cancer. The DNA nanoframeworks are synthesized via precipitation polymerization, utilizing acrylamide-modified DNA to initiate a hybridization chain reaction that facilitates the effective loading of MB-extended and sgRNA-conjugated DNA hairpins. The Cas9 protein is efficiently loaded into the nanoframeworks through phase transition-induced polymer chain rearrangement, overcoming steric hindrance. Upon aptamer-mediated internalization into PANC-1 cells, the overexpressed apurinic/apyrimidinic endonuclease 1 and ribonuclease H in cancer cells induce site-specific cleave of MB and DNA–RNA hybrid duplex, respectively. This cleavage restores fluorescence for specific optical detection, whereas the released Cas9 RNP performs gene editing for efficient therapy. Low fluorescence background and favorable biocompatibility are observed in normal cells. In a pancreatic cancer mouse model, the platform demonstrates significant detection-guided antitumor efficacy, highlighting its potential for precision medicine in cancer therapy.}, archive = {J_ANGEW}, author = {Nachuan Song and Ruoyu Tao and Hongjin Li and Rui Zhang and Yan Huang and Le Zhang and Ying Liu and Dayong Yang and Chi Yao}, doi = {10.1002/anie.202500566}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500566}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatially controlled co-delivery of diagnostic and therapeutic agents using DNA nanoframeworks for pancreatic cancer precision therapy}, volume = {64}, year = {2025}, }
• (2025). Advances and challenges in low-temperature upcycling of waste polyolefins via tandem catalysis. ANGEW, 64(22), e202500559. (www)

  @article{ , abstract = {Polyolefin waste is the largest polymer waste stream that could potentially serve as an advantageous hydrocarbon feedstock. Upcycling polyolefins poses significant challenges due to their inherent kinetic and thermodynamic stability. Traditional methods, such as thermal and catalytic cracking, are straightforward but require temperatures exceeding 400 °C for complete conversion because of thermodynamic constraints. We summarize and critically compare recent advances in upgrading spent polyolefins and model reactants via kinetic (and thermodynamic) coupling of the endothermic C─C bond cleavage of polyolefins with exothermic reactions including hydrogenation, hydrogenolysis, metathesis, cyclization, oxidation, and alkylation. These approaches enable complete conversion to desired products at low temperatures (<300 °C). The goal is to identify challenges and possible pathways for catalytic conversions that minimize energy and carbon footprints.}, archive = {J_ANGEW}, author = {Wei Zhang and Sungmin Kim and Michele L. Sarazen and Mingyuan He and Jingguang G. Chen and Johannes A. Lercher}, doi = {10.1002/anie.202500559}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500559}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Advances and challenges in low-temperature upcycling of waste polyolefins via tandem catalysis}, volume = {64}, year = {2025}, }
• (2025). Low strain mediated zn (0002) plane epitaxial plating for highly stable zinc metal batteries. ANGEW, 64(22), e202500380. (www)

  @article{ , abstract = {Optimizing the crystalline orientation to achieve stable Zn (0002) plane growth is pursued for highly reversible zinc metal batteries (ZMBs). However, the lattice strain of Zn substrate hinders stable Zn 2+ plating/stripping and sustainable epitaxial growth of Zn (0002) texture. Herein, we present a low-strain strategy to mediate nucleated-Zn grains for stabilizing Zn 2+ electrodeposition/stripping process and guiding sustainable Zn 2+ growth along (0002) surfaces. Fluorinated anthracene triptycene polymer (FATP) photopolymerized on Zn exhibits nanocrystalline structure with highly ordered nanochannels (1.5 nm), enabling oriented nucleation and sustainable epitaxial stacking of Zn (0002) plane due to low nucleation energy (0.2 vs. 1.1 e − Å −3 of pure Zn) and low grain strain (−0.2 to 0.4 vs. −0.9 to 0.9 MPa). Besides, the ordered porous FATP nanofilm refines electroplating Zn grains (9.4 vs. 26.7 µm), alleviating strain accumulation (3.7 vs. 28.2 MPa) and lattice distortion. Consequently, FATP-Zn||Cu cell achieves a high average Coulombic efficiency of 99.6% over 6000 cycles, while FATP-Zn||FATP-Zn cell shows stable plating/stripping after 5000 h. Notably, FATP-Zn||MnO 2 pouch cell (2.77 Ah) demonstrates stable operation over 1000 cycles. This work presents a new approach to designing Zn anodes with refined nucleated-Zn grains and sustainable Zn (0002) plane stacking for advanced ZMBs.}, archive = {J_ANGEW}, author = {Da Zhang and Yumin Chen and Xunwen Zheng and Pingxuan Liu and Ling Miao and Yaokang Lv and Ziyang Song and Lihua Gan and Mingxian Liu}, doi = {10.1002/anie.202500380}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500380}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low strain mediated zn (0002) plane epitaxial plating for highly stable zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Substituent modulation of contorted hexa-peri-benzocoronene-based conjugated Metal–Organic frameworks for high-performance capacitor. ANGEW, 64(22), e202500324. (www)

  @article{ , abstract = {Two-dimensional conjugated metal–organic frameworks (2D c-MOFs) exhibiting graphite-like van der Waals stacked layers have been recognized as a new type of crystalline conductive materials and have shown rapid progress in the last decade. However, the purposive design and modulation of their conductive properties and related application performance remains a challenge. Herein, we present a new type of 2D c-MOFs with contorted conformation and substituent-modulated structures for highperformance of the capacitor. Octahydroxy-hexa- peri -benzocoronene (HBCOH) with a contorted graphene nanosheet core is designed and synthesized as the ligand. The F-substituted 2D c-MOF FHBCOH-Cu demonstrates superior crystallinity and conductive properties exhibiting a record-breaking specific capacitance of 943 F g −1 at a rate of 0.5 A g −1 . The improved crystallinity, enhanced conductivity, and pore environment control enabled by halogen substitution, combined with the contorted conformation synergistically accomplish high performance of 2D c-MOFs as electrode materials in supercapacitors. This study introduces a novel molecular design strategy for the construction of 2D c-MOFs-based high-performance energy storage materials.}, archive = {J_ANGEW}, author = {Wansheng Liu and Yue Li and Liyao Liu and Ye Zou and Yimeng Sun and Yutao Cui and Chong-an Di and Daoben Zhu}, doi = {10.1002/anie.202500324}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500324}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Substituent modulation of contorted hexa-peri-benzocoronene-based conjugated Metal–Organic frameworks for high-performance capacitor}, volume = {64}, year = {2025}, }
• (2025). Urea-linked covalent organic framework as a li-ion guided channel enabling ultra-stable lithium metal anode in carbonate-based electrolyte. ANGEW, 64(22), e202500314. (www)

  @article{ , abstract = {Lithium (Li) metal exhibits great potential for achieving high-energy-density rechargeable batteries. However, the practical application of Li metal anodes is severely hindered by the uncontrollable growth of lithium dendrites as well as the instability of the spontaneously generated solid electrolyte interphase (SEI), causing safety concerns and lifespan issues. Herein, we customize a novel urea-linked covalent organic framework (COF-531) as an interfacial Li-ion guided channel. The COF-531 is constructed utilizing a highly dynamic urea-linkage, which balances the low reactivity of N-rich melamine (MA), and could simultaneously provide abundant lithiophilic N sites and crystallinity ordered ion channels. This structure is able to promote efficient Li + de-solvation and transport, leading to uniform deposition via inhibiting dendrites growth. As a result, the COF@Li anode exhibits remarkable cycling performance under high current density (10 mA cm −2 over 11500 h and 20 mA cm −2 over 6000 h in the symmetric Li cells, and 1013 mAh g −1 after 500 cycles under 8.4 A g −1 in a COF@Li || S-in-CMK-3 cell), setting a new benchmark for long-cycle performance in carbonate-based electrolyte. Remarkably, the COF-531 can be produced at a low-cost (∼58.6 USD kg −1 ) on a kilogram scale. This work addresses a critical bottleneck in the commercialization of Li-metal batteries.}, archive = {J_ANGEW}, author = {Caihong Zhang and Zhen Luo and Kean Chen and Chunxing Yan and Lezhi Yi and Chengtao Gong and Yuliang Cao and Fu-Sheng Ke}, doi = {10.1002/anie.202500314}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Urea-linked covalent organic framework as a li-ion guided channel enabling ultra-stable lithium metal anode in carbonate-based electrolyte}, volume = {64}, year = {2025}, }
• (2025). Illuminating lead coordination in perovskite precursors via fluorescence spectroscopy. ANGEW, 64(22), e202500294. (www)

  @article{ , abstract = {The properties of perovskite precursors critically determine the ultimate performance of perovskite devices, yet simple and accessible real-time precursor characterization methods remain scarce. Here, we systematically investigate the lead (Pb) coordination environment in perovskite precursors using fluorescence spectroscopy. By examining lead halide [PbX 6 ] 4− octahedra (X═Cl, Br, I) and monitoring their luminescence under different solvents and A-site cation compositions, we unveil how [PbX 6 ] 4− distinct aggregation states give rise to characteristic fluorescence “fingerprints.” We find that halide choice, solvent coordination, and A-site cations collectively exert pronounced effects on the photoluminescence (PL) peak positions, full width at half maximum (FWHM), and photoluminescence quantum yield (PLQY). Moreover, we demonstrate that fluorescence spectroscopy can capture subtle changes in intermediate perovskite structures—including low-dimensional nanoscale clusters and the formation of higher-dimensional networks. This robust optical method offers a powerful and straightforward approach for tracing the nucleation stage, evaluating solvent–solute and solute–solute interactions, and differentiating Pb coordination states in real time. The aggregation-induced emission (AIE) phenomenon of inorganic systems and the structure-activity relationship at the aggregate level have important guiding significance for the design of materials.}, archive = {J_ANGEW}, author = {Siwei Zhang and Jinjin Wang and Jinhui Jiang and Fulong Ma and Yifan Wang and Xinmeng Chen and Ryan T. K. Kwok and Zheng Zhao and Jacky W. Y. Lam and Ben Zhong Tang}, doi = {10.1002/anie.202500294}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500294}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Illuminating lead coordination in perovskite precursors via fluorescence spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Enhancing the reversibility and kinetics of heterovalent ion-substituted mn-based prussian blue analogue cathodes via intervalence charge transfer. ANGEW, 64(22), e202500254. (www)

  @article{ , abstract = {Mn 3+ (d 4 ) in manganese-based Prussian blue analogues (MnPBA) exhibits intrinsic orbital degeneracy upon sodiation/desodiation, resulting in severe Jahn–Teller distortion, which usually causes rapid capacity decay and sluggish kinetics. Unfortunately, traditional modification strategies are insufficient for electronic tuning of Mn 3+ to mitigate these issues. Herein, Intervalence Charge Transfer (IVCT) of manganese and iron to vanadium ions is unraveled in a series of novel V 3+ -substituted MnPBA to enhance electrochemical reaction reversibility and kinetics. IVCT drives electron distribution from localized to delocalized, achieves electronic coupling, and mitigates Jahn–Teller by transferring a single-electron of Mn 3+ e g orbital. Notably, the reported Na 1.2 V 0.63 Mn 0.58 Fe(CN) 6 cathode demonstrates excellent rate capability (136.9 mAh g −1 at 20 mA g −1 and 94.9 mAh g −1 at 20 A g −1 ), remarkable long-cycle stability (91.6 % capacity retention after 300 cycles at 20 mA g −1 and 90.7 % after 2000 cycles at 2 A g −1 ), and robust performance across a wide temperature range (98.59 % capacity after 300 cycles at −30 °C and 50 mA g −1 ), surpassing the majority of reported sodium-ion cathodes. The intrinsic functioning mechanism of IVCT and quasi-zero-strain reaction mechanism were adequately understood through systematic in situ/ex situ characterizations. This study further develops electron-tuning of PBA, opening a new avenue toward advanced sodium-ion battery cathode materials.}, archive = {J_ANGEW}, author = {Lingtong Kong and Zhongxin Jing and Muhammad Mamoor and Yifan Jiang and Yanjun Zhai and Guangmeng Qu and Lu Wang and Bin Wang and Liqiang Xu}, doi = {10.1002/anie.202500254}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500254}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing the reversibility and kinetics of heterovalent ion-substituted mn-based prussian blue analogue cathodes via intervalence charge transfer}, volume = {64}, year = {2025}, }
• (2025). Nuclear-targeted material enabled intranuclear MicroRNA imaging for tracking gene editing process. ANGEW, 64(22), e202500052. (www)

  @article{ , abstract = {Gene editing technology based on clustered regularly interspaced short palindromic repeats/associated protein (CRISPR/Cas) systems serves as an efficient tool in cancer therapy. Tracking the gene editing process can help identify the progress of cancer treatment. However, existing techniques for monitoring the gene editing process rely on lysed cells, which can not reflect the dynamic changes of nucleic acid in living cells. It urgently needs in situ and real-time imaging technologies to track the gene editing process at a living single-cell level more effectively and precisely. Here, we reported a highly efficient nuclear-targeted material, phenylboronic acid modified linear PEI (LPBA), for loading gene editing plasmids and fluorescent probes to track gene editing processes of microRNA. Based on LPBA, we achieved efficient intranuclear microRNA imaging at the living cell level, reaching 32.4-fold higher than the linear PEI (LPEI) delivery system, which facilitated further sensitive monitoring of the gene editing process both in living cells and in vivo. Meanwhile, this efficient gene-editing and real-time detection technique could be extended to screening effective gene-editing plasmids. Such LPBA-based imaging technology extended the imaging area of microRNA and offered new insight in the field of gene editing and nucleic acid detection.}, archive = {J_ANGEW}, author = {Jiayan Wu and Meng Meng and Zhaopei Guo and Kai Hao and Yonghao Liang and Hanyu Meng and Guanhe Fang and Zongwei Shi and Xiaoya Guo and Huixin Li and Yuanji Feng and Lin Lin and Jie Chen and Yingchao Zhang and Huayu Tian and Xuesi Chen}, doi = {10.1002/anie.202500052}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202500052}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nuclear-targeted material enabled intranuclear MicroRNA imaging for tracking gene editing process}, volume = {64}, year = {2025}, }
• (2025). Programmable mono-/Di-alkylation of amines with aldehydes over a Pdδ−–H electrocatalyst. ANGEW, 64(22), e202425622. (www)

  @article{ , abstract = {Programmable amine N-alkylation provides a new method to combine the required alkyl groups with amine molecules according to actual demand and to precisely regulate the biological and pharmaceutical properties of life science amine molecules. However, only the electrochemical mono-methylation of amines has been achieved via C─N coupling with CO 2 accompanied by an unsatisfactory Faraday efficiency (FE) lower than 10%. Herein, we developed programmable electrocatalytic N-alkylation of amines with two controllable alkyl groups and one methyl group. Both experimental characterization and density functional theory (DFT) calculations have demonstrated the critical role of electron-enriched Pd metals in transforming amines into alkylamines with two chosen alkyl groups and a methyl group. Moreover, the electrocatalytic transformation of amines to alkylamines with satisfactory FE values (86%–96%) has been achieved, further expanding the scope of electrochemical C─N coupling and possibly opening a new world of electrochemical amine N-alkylation.}, archive = {J_ANGEW}, author = {Si-Yuan Xia and Shi-Nan Zhang and Dong Xu and Bing-Liang Leng and Kai-Yuan Lu and Jie-Sheng Chen and Xin-Hao Li}, doi = {10.1002/anie.202425622}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425622}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programmable mono-/Di-alkylation of amines with aldehydes over a Pdδ−–H electrocatalyst}, volume = {64}, year = {2025}, }
• (2025). Low-temperature depolymerization of polymethacrylamides. ANGEW, 64(22), e202425575. (www)

  @article{ , abstract = {The depolymerization of polymers synthesized by reversible deactivation radical polymerization (RDRP) has recently garnered significant attention due to its potential for recovering monomers at low temperatures. However, current reports focus solely on polymethacrylates, significantly limiting applications, scope, and fundamental understanding. Although polymethacrylamides are highly valued for their excellent biocompatibility, antibacterial properties, and water solubility, their chemical recycling remains experimentally unattainable, irrespective of their synthesis method (i.e., free radical, RDRP, anionic, etc.). Herein, we present the first example of thermal reversible addition-fragmentation chain-transfer (RAFT) depolymerization of various polymethacrylamides, regenerating monomers at high yields. Central to our work was the identification of two key weaknesses associated with polymethacrylamides, namely, i) insufficient end-group activation, and ii) premature end-group loss at higher temperatures, leading to compromised monomer yields and low depolymerization rates. These challenges were bypassed via the addition of commercially available radical initiators, resulting in faster reactions and higher percentages of recovered monomer at as low as 90 °C. The broad applicability of this method was further demonstrated by its compatibility with various RAFT agents, and the possibility to depolymerize a crosslinked hydrogel. Our work expands the depolymerization scope of high-value materials beyond polymethacrylates and shines a light on intriguing thermodynamic and kinetic insights.}, archive = {J_ANGEW}, author = {Victoria Lohmann and Glen R. Jones and Asja A. Kroeger and Nghia P. Truong and Michelle L. Coote and Athina Anastasaki}, doi = {10.1002/anie.202425575}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425575}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-temperature depolymerization of polymethacrylamides}, volume = {64}, year = {2025}, }
• (2025). Near-infrared light-responsive immunomodulator prodrugs rejuvenating immune microenvironment for “Cold” tumor photoimmunotherapy. ANGEW, 64(22), e202425309. (www)

  @article{ , abstract = {Light-activatable prodrugs have been applied in precision cancer therapy because of their spatiotemporal controllability and minimal toxic side effects. However, the reported prodrugs were limited by the ultraviolet and visible light regions, which seriously restricted their application in deep tissues. Developing a near-infrared (NIR) light-activatable release system remains a great challenge. Herein, the 808 nm light-activatable prodrugs were constructed with imiquimod (R837) and NIR boron dipyrromethene (BODIPY) via a reactive oxygen species (ROS)-cleavable linker for photoimmunotherapy of “cold” cancer. ROS produced by BODIPY could cleave the linker under 808 nm laser irradiation, and R837 was released spatiotemporally at the tumor site. The combination of the immune response produced by R837 and immunogenic cell death caused by phototherapy significantly potentiated adaptive antitumor immunity and enhanced cytotoxic CD8 + T cell infiltration for tumor metastasis and distant tumor inhibition. This work provides an effective NIR light-activatable controlled release system for cancer immunotherapy and metastasis suppression.}, archive = {J_ANGEW}, author = {Jiaping Shen and Bin Xu and Yun Zheng and Xingyu Zhao and Huixuan Qi and Yongan Tang and Wenhai Lin and Shengliang Li and Zhiyuan Zhong}, doi = {10.1002/anie.202425309}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425309}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared light-responsive immunomodulator prodrugs rejuvenating immune microenvironment for “Cold” tumor photoimmunotherapy}, volume = {64}, year = {2025}, }
• (2025). Catalytic ring expansion of furyl hydrosilanes: Synthesis of 1,2-oxasilines as diels-alder diene components. ANGEW, 64(22), e202425232. (www)

  @article{ , abstract = {The development of new methods for aromatic ring-expansion offers a strategic means of transforming abundant aromatic feedstocks into intricate structures via skeletal editing, thereby unlocking valuable avenues for organic synthesis. We report herein a mild and efficient ruthenium-catalyzed ring-expansion of 2-silylfurans to form 1,2-oxasilines with wide substrate scope and excellent functional group tolerance. Density functional theory (DFT) calculations suggest the reaction proceeds through regioselective insertion of furan double bond into a Ru─H bond, followed by skeletal rearrangement, 1,2-hydride transfer, and elimination steps. The resulting 1,2-oxasilines are electron-rich cyclic dienes with an extrudable and transformable Si─O linker, which exhibit unique and versatile reactivity in Diels–Alder cyclization with electron-deficient dienophiles, enabling modular assembly of molecular skeletons with higher complexity.}, archive = {J_ANGEW}, author = {Qiaoxing He and Zheyuan Xu and Huaquan Fang and Sifan Liu and Xi Lu and Xin Hong and Yao Fu and Guixia Liu and Zheng Huang}, doi = {10.1002/anie.202425232}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425232}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic ring expansion of furyl hydrosilanes: Synthesis of 1,2-oxasilines as diels-alder diene components}, volume = {64}, year = {2025}, }
• (2025). An ultra-stable 2D linear polymer cathode for high-performance aqueous zinc-organic batteries. ANGEW, 64(22), e202425082. (www)

  @article{ , abstract = {Two-dimensional structure of cathode materials possesses fast kinetics in aqueous zinc ion batteries. However, in organic linear polymers it is rare to form two-dimensional structures due to the bond rotations of the polymerization reaction. In this work, inspired by the process of forming carbon fibers from polyacrylonitrile, a novel two-dimensional linear polymer (2DLP) of poly(2H,11H-bis[l,4]triazino[3,2-b : 3′,2′-m]triphenodithiazine-3,12-diyl-2,11-diyli-dene-11,12-bis[methyldene]) (PTL) cathode materials were prepared for aqueous zinc-ion battery cathode materials by designing ladder structure polymer molecules with highly restricted bond rotations. PTL possess fast cations diffusion (4.27×10 −7 cm −1 s −1 ) due to its layered structure. Moreover, the PTL electrodes exhibit an ultra-long cycle stability (7000 cycles still remain 87 % capacity remains). Meanwhile, as PTL mass loading increase from 3.13 to 6.27 mg cm −2 , the specific capacity kept 98 % retention after 100 cycles. Besides, the assembled Zn/PTL flexible pack battery exhibits a 6.6 mAh capacity at 0.5 A g −1 . Furthermore, though a range of ex site analysis, it was supported that the charge storage mechanism of PTL is driven by the imine moiety, and accompanies by the insertion and extraction of Zn 2+ /H + ions. This work attempts to provide a new sight of improve the poor ion diffusion coefficient of organic materials.}, archive = {J_ANGEW}, author = {Linwei Zhao and Yunqi Jia and Yiwen Wu and Tengteng Gu and Xuanyi Zhou and Xiaodong Wang and Leheng Zhong and Shuai Zhan and Haiming Lv(Lyu) and Chunyi Zhi and Jun Liu}, doi = {10.1002/anie.202425082}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425082}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An ultra-stable 2D linear polymer cathode for high-performance aqueous zinc-organic batteries}, volume = {64}, year = {2025}, }
• (2025). Spatially coupling Electronic–Ionic transport in organic mixed conductors as cathodes for efficient Zn–V batteries. ANGEW, 64(22), e202425080. (www)

  @article{ , abstract = {In conventional electrodes, concentration polarization by unbalanced charge transport and solid-state diffusion resistance result in sluggish reaction kinetics, hindering the practical application of zinc-ion batteries. Here, we propose an integrated mixed electronic–ionic conductor by spatially coupling charge transport pathways, which could achieve redistribution and fast transport of charge (Zn 2+ /e − ). Operando electrochemical quartz crystal microbalance and electrochemical impedance spectroscopy revealed the charge transport mechanisms and intrinsic conducting characteristics at timescale. Through confinement by vanadium oxide, dual-conductive pathways were self-assembled at the nanoscale and provided effective charge storage. This provided high charge density and accelerated ionic diffusion in the bulk phase, resulting in more active sites and faster reaction kinetics. Moreover, reversible ionic channels from the self-doping/de-doping process reduced the dissolution of active materials by protons and enabled conversion chemistry, improving cycling stability at low current density. Consequently, the modulated cathode (PEDOT-SO 3 -ZnVO) delivered a high-rate performance of 310/148 mAh g −1 (0.2/10 A g −1 ) at 10 mg cm −2 . Importantly, the conventional electrode at 21 mg cm −2 achieved an ultra-high areal capacity of 6.0 mAh cm −2 and superior cycling stability (79.1% retention over 100 cycles at 0.2 A g −1 ). This work opens the way for the precise modulation of the electrochemical performance of functional nanomaterials.}, archive = {J_ANGEW}, author = {Meihua Zhu and Rui Gao and Qing Ran and Shen-gen Gong and Qiao Li and Shu-Pei Zeng and Houhou Huang and Linglong Hu and Daming Yang and Tianyi Dai and Ying Wang and Danming Chao and Ming Feng and Zhongwei Chen}, doi = {10.1002/anie.202425080}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425080}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatially coupling Electronic–Ionic transport in organic mixed conductors as cathodes for efficient Zn–V batteries}, volume = {64}, year = {2025}, }
• (2025). Modular synthesis of dendritic oligo-glycerol cationic surfactants for enhanced antibacterial efficacy. ANGEW, 64(22), e202425069. (www)

  @article{ , abstract = {Bacterial infections and antibiotic resistance present an ever-increasing threat to human health worldwide, and medicine urgently needs new alternatives for the successful treatment of bacterial infections. Cationic surfactants have proven to be effective antibacterial agents due to their ability to disrupt bacterial membranes, inhibit biofilm formation, and combat a broad spectrum of pathogens. We employed a orthogonal click chemistry strategy for the efficient modular synthesis of six novel cationic surfactants. Our results emphasize the strong correlation between the surfactant design and its antibacterial potential. Among these six cationic surfactants we identified a prime candidate, which possessed an impressive antibacterial effect against gram-positive and gram-negative bacteria, including drug-resistant strains. We found that our surfactant can prevent biofilm formation and eradicate already existing biofilms. Cryo-TEM imaging was used to reveal the membrane-disrupting properties of the surfactant. In-vivo wound healing experiments underline the surfactants’ ability to inhibit wound infections. Cationic surfactants often face the challenge of balancing strong antibacterial activity with minimal cytotoxicity. Our strategic design and orthogonal click chemistry approach have enabled precise fine-tuning of molecular structures to achieve an optimal balance between antibacterial efficacy and biocompatibility, effectively overcoming this critical limitation.}, archive = {J_ANGEW}, author = {Natalie Hanheiser and Yuhang Jiang and Christian Zoister and Mathias Dimde and Katharina Achazi and Chuanxiong Nie and Yuanyuan Li and Rainer Haag and Abhishek K. Singh}, doi = {10.1002/anie.202425069}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular synthesis of dendritic oligo-glycerol cationic surfactants for enhanced antibacterial efficacy}, volume = {64}, year = {2025}, }
• (2025). Evaporation-assisted synthesis of olympic gels. ANGEW, 64(22), e202425034. (www)

  @article{ , abstract = {Catenated networks exclusively composed of intertwining rings were first envisioned as “Olympic gels” by Pierre-Gilles de Gennes four decades ago but have not been successfully prepared in artificial materials yet due to the challenge in synthesis. Herein, we present a bio-inspired, evaporation-assisted strategy to address this issue. In our design, the evaporation of liquid catalysts that induce ring-chain equilibrium of polymer systems drives macrocycles to encounter and assists their catenation through reversible cyclization. Complete removal of liquid catalysts stabilizes the resulting ring-interlocked networks by deactivating the catenation-decatenation process. The strategy is demonstrated by the system of hydroxyethyl lipoate (LpHE) and dimethyl formamide (DMF). The results indicate that DMF evaporation leads to the formation of global LpHE polycatenane networks. This evaporation-assisted strategy displays versatility in several tested cyclic monomers, highlighting its potential as a general approach to fabricate ring-interlocked elastomers and topologically intricate materials.}, archive = {J_ANGEW}, author = {Xinhong Xiong and Mingju Xue and Lulu Xue and Luzhi Zhang and Zhongyan Zhang and Jian Chen and Guojie Zhang and Hong Liu and Jiaxi Cui}, doi = {10.1002/anie.202425034}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202425034}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evaporation-assisted synthesis of olympic gels}, volume = {64}, year = {2025}, }
• (2025). Optical probes for cellular imaging of G-quadruplexes: Beyond fluorescence intensity probes. ANGEW, 64(22), e202424931. (www)

  @article{ , abstract = {The study of G-quadruplex (G4) structures that form in DNA and RNA is a rapidly growing field, which has evolved from in vitro studies of isolated G4 sequences to genome-wide detection of G4s in a cellular context. This work has revealed the tangible and significant effects that G4s may have on biological regulation. This minireview describes recent progress in the design of photoluminescent intensity-independent optical probes for G4s. We discuss the design and use of probes based on fluorescence or phosphorescence lifetime, rather than intensity-based detection; spectral ratiometric probes; and fluorescent probes for single-molecule G4-detection. We argue that each of these modalities improve unbiased G4 detection in cellular experiments, overcoming problems associated with unknown cellular uptake of probes or their organelle concentration. We discuss the improvements offered by these types of probes, as well as limitations and future research directions needed to facilitate more robust research into G4 biology.}, archive = {J_ANGEW}, author = {Jenna Robinson and Aatikah Majid and Marina K. Kuimova and Ramon Vilar}, doi = {10.1002/anie.202424931}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424931}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optical probes for cellular imaging of G-quadruplexes: Beyond fluorescence intensity probes}, volume = {64}, year = {2025}, }
• (2025). Revealing collaborative effects of binary additives on regulating precursor crystallization toward highly efficient perovskite solar cells. ANGEW, 64(22), e202424910. (www)

  @article{ , abstract = {Fabricating high-quality perovskite layers is essential for achieving high-performance solar cells. Considering the significant advancements made in additive engineering for optimizing perovskite crystallization using single additive, exploring the collaborative effect of dual additives on precursor for perovskite crystallization may be an effective way for further advancing device performance. Herein, a binary additives strategy is proposed, where phenylmethylammonium iodide (PMAI) and [2-(9 H -carbazol-9-yl)ethyl]phosphonic acid (2PACz) are introduced into the precursor. Compared with the precursor with no additives or a single additive (PMAI or 2PACz), the use of dual additives more effectively cleaves edge-shared Pb-I octahedra to expedite the transformation from PbI 2 to PbI 3 − complexes as prenucleation clusters and produces much larger colloidal particles with accelerated nucleation. Concurrently, the crystallization in both spin-coating and annealing processes is significantly retarded due to the stronger interaction between perovskite and binary additives. Benefiting from such rapid nucleation and slow crystallization, high-quality perovskite layer with larger-sized crystals and fewer defects is formed, resulting in mitigated microstrain, enhanced charge extraction, and suppressed nonradiative recombination. Consequently, the device derived from the use of dual additives could achieve an impressive efficiency of 26.05% (certified 25.49%) and retained 90% of its initial efficiency after 1200 h of maximum power point tracking.}, archive = {J_ANGEW}, author = {Shaoyu Geng and Song Zhang and Nan Shen and Geping Qu and Haojiang Shen and Jiayu Hu and Jie Yang and Yeming Jin and Ya Li and Ruirui Cao and Huayang Li and Zhitao Shen and Zong-Xiang Xu and Shi Chen and Alex K.-Y. Jen}, doi = {10.1002/anie.202424910}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424910}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing collaborative effects of binary additives on regulating precursor crystallization toward highly efficient perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Proximal and remote hydrocarboxylation of alkenes with carbon dioxide enabled by nickel-catalyzed hydrogen atom transfer. ANGEW, 64(22), e202424790. (www)

  @article{ , abstract = {The utilization of carbon dioxide and alkenes as feedstocks for the synthesis of carboxylic acids holds great significance in the realm of sustainable chemistry. Nonetheless, achieving selective C─H bond carboxylation of alkenes with broad applicability has long been a challenging task. Herein, we present a straightforward and unifying approach for the preparation of α-carboxylic acids through nickel-catalyzed radical hydrocarboxylation of both functionalized and unactivated, simple alkenes, at proximal and remote sites. Notably, this operationally simple catalytic reaction exhibits a broad substrate scope, having excellent regio- and chemoselectivities, and is suitable for late-stage carboxylation of bioactive molecules. Preliminary mechanistic investigations showed that a nickel-catalyzed hydrogen atom transfer (Ni-HAT) pathway is in operation, accounting for the site-selective hydrocarboxylation protocol for various alkene substrates.}, archive = {J_ANGEW}, author = {Rong-De He and Yixin Lu}, doi = {10.1002/anie.202424790}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proximal and remote hydrocarboxylation of alkenes with carbon dioxide enabled by nickel-catalyzed hydrogen atom transfer}, volume = {64}, year = {2025}, }
• (2025). Trifunctionalization of iodoarenes via sequence-controlled double ortho C─H acylations by Palladium/Norbornene catalysis. ANGEW, 64(22), e202424604. (www)

  @article{ , abstract = {Herein we report a novel palladium/norbornene-catalyzed trifunctionalization reaction of ortho -unsubstituted iodoarenes by incorporating two distinct acyl groups at their ortho C─H positions and replacing the ipso -iodide with an alkenyl or aryl group. Notably, this transformation was enabled by the alkyl/aryl mixed anhydrides, which were utilized as dual acylation reagents by abstracting their central oxygen atom with electrophilic 2-chloro-4,6-dimethoxy-1,3,5-triazine. Mechanistic studies revealed that the alkyl-acyl unit of such an anhydride was employed for the first C─H alkyl-acylation, and in situ released aryl carboxylate anion was then rapidly activated with triazine chloride to provide an aryl–acyl electrophile for the second C─H acylation, thus enabling the trifunctionalization of iodoarenes by termination with an intermolecular Heck or intramolecular arylation reaction. In addition, the synthetic utility of this method is exemplified by the selective manipulation of carbonyl groups of the products.}, archive = {J_ANGEW}, author = {Yong Xu and Lifeng Wang and Aohua Yang and Jingyun Ren and Jingjing Liu and Xinjun Luan}, doi = {10.1002/anie.202424604}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424604}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Trifunctionalization of iodoarenes via sequence-controlled double ortho C─H acylations by Palladium/Norbornene catalysis}, volume = {64}, year = {2025}, }
• (2025). Highly stable Sn─Pb perovskite solar cells enabled by phenol-functionalized hole transporting material. ANGEW, 64(22), e202424515. (www)

  @article{ , abstract = {Sn─Pb perovskites, a most promising low bandgap semiconductor for multi-junction solar cells, are often limited by instability due to the susceptibility of Sn 2+ to oxidation. Inspired by the antioxidative properties of polyphenolic compounds, we introduce the reductive phenol group and strong electronegative fluorine into an organic conjugated structure and design a multi-functional polymer with fluorine and phenol units (PF─OH). The design of PF─OH allows the effective rise in the energy barrier of Sn 2+ oxidation, leading to a significant enhancement in the stability of Sn─Pb perovskite devices from 200 to 8000 h—an improvement of around 100 times. Additionally, the strong binding energy between Sn 2+ and the phenol in PF─OH critically influences Sn─Pb perovskite's crystallization and grain growth, resulting in perovskite films with fewer pinholes at the buried interface and extended carrier lifetimes. This enhancement not only boosts the power conversion efficiency (PCE) to 23.61%, but also significantly improves the operational stability of the devices. Ultimately, this design strategy has been proven universal through the phenolization of a series of molecules, marking a milestone in enhancing the stability of Sn─Pb perovskites.}, archive = {J_ANGEW}, author = {Jianchang Wu and Manman Hu and Qingqing Dai and Ecem Aydan Alkan and Anastasia Barabash and Jiyun Zhang and Chao Liu and Jens A. Hauch and Gao-Feng Han and Qing Jiang and Tonghui Wang and Sang Il Seok and Christoph J. Brabec}, doi = {10.1002/anie.202424515}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424515}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly stable Sn─Pb perovskite solar cells enabled by phenol-functionalized hole transporting material}, volume = {64}, year = {2025}, }
• (2025). Efficient upcycling of polyolefin waste to light aromatics via coupling C─C scission and carbonylation. ANGEW, 64(22), e202424334. (www)

  @article{ , abstract = {The upcycling of waste polyolefins into light aromatics has great potential to generate hundreds of millions of tons of valuable aromatic carbon feedstock. However, the conventional high-temperature radical cracking method for aromatizing polyolefins on zeolites faces challenges in aromaticity control and rapid deactivation due to coke. Here, we present a unique strategy that integrates the traditional cracking-aromatization process of PE with CO insertion, a key step of Fischer–Tropsch synthesis, achieving a rise of yield of light aromatics by four times, with an absolute value up to 67% by weight at only 280 °C. The insertion of CO into the Ru-alkyl intermediates formed during polyolefin cracking facilitates the generation of active oxygenate species, guarantees an ideal C─C chain length range, and smooths the way for subsequent efficient aromatization on Hol-ZSM-5@S1 with a short b axis. According to the technical economic analysis, this low-carbon-footprint and economic approach can reduce approximately 1/3 of carbon emissions compared to traditional naphtha cracking technologies and holds promise for reshaping the global aromatic hydrocarbon cycle of the petrochemical industry through polyolefin degradation.}, archive = {J_ANGEW}, author = {Ruiliang Gao and Shanjun Mao and Bing Lu and Wencong Liu and Yong Wang}, doi = {10.1002/anie.202424334}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424334}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient upcycling of polyolefin waste to light aromatics via coupling C─C scission and carbonylation}, volume = {64}, year = {2025}, }
• (2025). Enantioselective total synthesis of fortimicin b. ANGEW, 64(22), e202424235. (www)

  @article{ , abstract = {Fortimicins, featuring a pseudodisaccharide scaffold, are an unusual class of aminoglycosides (AGs) with potent efficacy against several aminoglycoside-resistant bacterial strains. Notably, these molecules also exhibit lower inherent ototoxicity and nephrotoxicity than common aminoglycosides. Consequently, fortimicins are a promising type of protoypical molecules for the development of the next generation of aminoglycoside antibiotics. Here, we report the asymmetric total synthesis of fortimicin B in 12 steps (longest linear sequence, LLS) from readily available starting materials. An enantioselective Cu(II)-catalyzed inverse-electron-demand Diels–Alder (IEDDA) reaction of 2-pyrones and N -substituted 2-oxazolones was developed for the efficient synthesis of the fortamine fragment, which previously required a lengthy multistep synthesis owing to its complex stereochemistry. The 6- epi -purpurosamine B fragment was efficiently synthesized through a Cr(II)/Co(I)-mediated C─C bond coupling between aldehydes and alkyl halides. Within these two fragments, the stereoselective construction of the α-glycosidic bond of fortimicin B was realized via the gold(I)-catalyzed glycosylation. Overall, this study provides an efficient synthetic platform for future investigations into the structure–activity relationships of fortimicins.}, archive = {J_ANGEW}, author = {Yang Lu and Xin-Yu You and Qianwei Zhang and Qi-Tao Lu and Jun-Li Hou and Quan Cai}, doi = {10.1002/anie.202424235}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424235}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective total synthesis of fortimicin b}, volume = {64}, year = {2025}, }
• (2025). Electrical energy storage by poly(ionic liquids). ANGEW, 64(22), e202424185. (www)

  @article{ , abstract = {Manipulating van der Waals (vdW) and ionic interactions in polymers enable energy storage and formations of active or passive components of electrical circuits. The energy storage is achieved by electrically activating ion pairs containing polymers, which create ergotropically favorable non-equilibrium gradient states. Molecular-level events responsible for this behavior involve concurrent ion pairs' polarization-depolarization gradients and conformational changes of aliphatic tails that collectively contribute to lowering local disorder states. Manipulating ionic and vdW interactions stabilizes polarized anion-cation pairs, thus maintaining electrical energy storage for extended periods. These transparent and easily moldable materials require no multilayered assemblies, and their functional features depend upon polarization conditions and ionic-vdW interactions, making them applicable in energy storage and other devices transcending classical time intricacy limits.}, archive = {J_ANGEW}, author = {Jiahui Liu and Tingwei Zhang and Sourav Biswas and Marek W. Urban}, doi = {10.1002/anie.202424185}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424185}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrical energy storage by poly(ionic liquids)}, volume = {64}, year = {2025}, }
• (2025). Approach toward stereoselective α-arylation by Pd/Cu-catalyzed arylboration of electron deficient alkenes. ANGEW, 64(22), e202424073. (www)

  @article{ , abstract = {Palladium-catalyzed cross coupling of enolates—α-arylation—is an established method for chemical synthesis. A major challenge in the field is control of stereochemistry for the α-carbon. This is typically due to facile epimerization under the basic reaction conditions for α-arylation. In this study, an alternative approach is presented that involves the Pd/Cu-catalyzed arylboration of electron deficient alkenes. The products are generated with high levels of diastereoselectivity for a broad range of substitution patterns. Enantioselective variants are also presented in addition to product derivatizations.}, archive = {J_ANGEW}, author = {Suman Das and Maeve A. Reilly and Stanna K. Dorn and Allison M. Pearson and M. Kevin Brown}, doi = {10.1002/anie.202424073}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Approach toward stereoselective α-arylation by Pd/Cu-catalyzed arylboration of electron deficient alkenes}, volume = {64}, year = {2025}, }
• (2025). “Naked nickel”-catalyzed Heteroaryl–Heteroaryl Suzuki–Miyaura coupling. ANGEW, 64(22), e202424051. (www)

  @article{ , abstract = {In this article, we report that the air-stable “naked nickel”, [Ni( 4-CF3 stb) 3 ], is a competent catalyst in the catalytic Suzuki–Miyaura cross-coupling reaction (SMC) between heteroaryl bromides and heteroaromatic boron-based nucleophiles. The catalytic system is characterized by its ability to avoid decomposition or deactivation in the presence of multiple Lewis basic sites. The protocol permits the formation of C‒C bonds between two heteroaryl moieties in the absence of complex exogenous ligands, thus minimizing screening procedures and simplifying reaction setups. This method accommodates combinations of distinct 6-membered heteroaryl bromides and 5- and 6-membered heterocyclic B -based nucleophiles.}, archive = {J_ANGEW}, author = {Rakan Saeb and Byeongdo Roh and Josep Cornella}, doi = {10.1002/anie.202424051}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202424051}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Naked nickel”-catalyzed Heteroaryl–Heteroaryl Suzuki–Miyaura coupling}, volume = {64}, year = {2025}, }
• (2025). Constructing stable and wavelength-extended heptamethine cyanines via donor ectopic substitution for NIR-IIa/b bioimaging. ANGEW, 64(22), e202423978. (www)

  @article{ , abstract = {Organic NIR-II dyes, particularly cyanine fluorophores, offer high molar extinction coefficients, biocompatibility, and structural tunability and are popular for noninvasive, high-resolution, and -contrast in vivo imaging. However, achieving stable, long-wavelength, and large Stokes shift NIR-II cyanine suitable for NIR-IIa/IIb bioimaging is still a formidable challenge. Herein, we introduce a novel strategy that extends the emission wavelength by the enhanced Highest occupied molecular orbital (HOMO)–Lowest occupied molecular orbital (LUMO) separation through simple donor ectopic substitution at the terminal structure of NIR-II cyanine. Compared to the original NIR-II cyanine Flav7, these novel dyes (NIR-ACs) exhibited a significant emission redshift and larger Stokes shift, with the maximum emission wavelength exceeding 1300 nm (NIR-IIa) and a tail emission exceeding 1500 nm (NIR-IIb). Notably, they also demonstrate excellent stability and deeper tissue imaging ability in vivo imaging. Finally, through surface modification of nanoparticles, NIR-ACs nanoparticles (NPs) have successfully achieved high-contrast tumor and bone-targeted detecting as well as multicolor imaging, providing robust tools for in vivo diagnostics and biomedical research.}, archive = {J_ANGEW}, author = {Yi-Feng Ou and Hong-Ya Xiang and Xu Yang and Ren-Xuan Wang and Shuang-Yan Huan and Lin Yuan and Tian-Bing Ren and Xiao-Bing Zhang}, doi = {10.1002/anie.202423978}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202423978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing stable and wavelength-extended heptamethine cyanines via donor ectopic substitution for NIR-IIa/b bioimaging}, volume = {64}, year = {2025}, }
• (2025). Hydrophobicity-controlled self-assembly of supramolecular peptide nanotubes in water. ANGEW, 64(22), e202423828. (www)

  @article{ , abstract = {Polymer-conjugated peptides are attractive building blocks for the construction of new nanomaterials. However, the ability to control the self-assembly of these materials remains a major limitation to their wider utilization. Herein, we report a facile strategy to fine-tune the assembly of water-soluble hydrophilic polymer-conjugated cyclic peptides by incorporating a defined, short hydrocarbon linker between the polymer and peptide. This addition creates a well-defined hydrophobic “inner shell” that suppresses water from disrupting the organized peptide hydrogen bond network. Our approach is demonstrated using a series of cyclic peptide-linker-PDMA conjugates that were evaluated by asymmetric flow field flow fractionation, small angle neutron scattering and transmission electron microscopy. Molecular dynamics simulations were also used to show how the polymer and the peptide stacks interact and illustrate the impact of this hydrophobic inner shell approach. This strategy provides a modular approach to fine control the nanotube self-assembling behavior. We expect that this technique will improve the versatility of peptide nanotubes for the engineering of advanced nanomaterials.}, archive = {J_ANGEW}, author = {Min Zeng and William Parsons and Yixuan Chen and David K. Chalmers and Sébastien Perrier}, doi = {10.1002/anie.202423828}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202423828}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrophobicity-controlled self-assembly of supramolecular peptide nanotubes in water}, volume = {64}, year = {2025}, }
• (2025). Macromolecule-enriched solvation enabling high-voltage sodium-ion batteries. ANGEW, 64(22), e202423625. (www)

  @article{ , abstract = {Sodium-ion batteries (SIBs) are emerging as a viable alternative for sustainable and cost-effective energy storage, yet their energy density is curtailed by relatively low voltage outputs (< 4 V) due to the lack of high-voltage electrolytes. Here, for the first time, we describe a high-voltage Na + electrolyte featuring a macromolecule-enriched solvation architecture. The vulnerable small molecules in the Na + solvation shell are replaced by macro polyamide (PA) molecules with high thermodynamic resilience, ensuring a wide electrochemical stability window for the electrolytes with suppressed oxidative/reductive decomposition. Concomitantly, the anions engage in H-bonding with the amido groups of PA, which not only stabilizes the anions against hydrolysis, but also delivers a high Na + transference number of 0.93. Importantly, the nitrogen-rich composition of the macromolecule-enriched electrolyte (MEE) fosters the formation of robust nitride interphases that impart enduring stability to both the cathode and anode. As a result, the hard carbon (HC) || NaNi 1/3 Fe 1/3 Mn 1/3 O 2 (NFM) full cells demonstrate significant rechargeability even with an ultrahigh cutoff voltage of 4.4 V. Our approach distinctively avoids the use of fluorinated molecules typically found in (localized-) high-concentration electrolytes, presenting a novel principle that could revolutionize high-voltage electrolyte design.}, archive = {J_ANGEW}, author = {Zhiming Zhao and Chen Liu and Tianxing Lai and Zehao Cui and Arumugam Manthiram}, doi = {10.1002/anie.202423625}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202423625}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Macromolecule-enriched solvation enabling high-voltage sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Photoinduced electron transfer across phospholipid bilayers in anaerobic and aerobic atmospheres. ANGEW, 64(22), e202423393. (www)

  @article{ , abstract = {In natural photosynthesis, light-driven electron transfer across the thylakoid membrane enables efficient charge separation and the confinement of reaction spaces for generating NADPH and CO 2 and oxidation of water. These reactions are complementary redox reactions and require different reaction conditions for optimal performance. However, current artificial photosynthesis studies only take place in the bulk and are sensitive toward oxygen and air, which limits their applicability under aerated and water-splitting conditions. Herein, we report light-driven electron transfer across a lipid bilayer membrane of liposome vesicles via a rigid oligoaromatic molecular wire that allows to electronically connect an oxidation and reduction reaction which are spatially separated by the membrane. The molecular wire has a simple, symmetric, easy-to-synthesize design based on benzothiadiazole and fluorene units and absorbs in the visible spectrum which makes it suitable for solar energy conversion. The model reactions in this study are light-driven NADH oxidation on one side of the membrane and light-driven reduction of an organic water-soluble dye in the bulk phase of liposomes. Additionally, the system is active in both aerobic and anaerobic atmospheres, rendering it ideal for aerobic conditions or reactions that produce oxygen such as solar-driven water splitting and artificial photosynthesis applications.}, archive = {J_ANGEW}, author = {Novitasari Sinambela and Richard Jacobi and Dieter Sorsche and Leticia González and Andrea Pannwitz}, doi = {10.1002/anie.202423393}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202423393}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoinduced electron transfer across phospholipid bilayers in anaerobic and aerobic atmospheres}, volume = {64}, year = {2025}, }
• (2025). Photoredox autocatalysis: Towards a library of generally applicable sulfonamide reductive photocatalysts. ANGEW, 64(22), e202423190. (www)

  @article{ , abstract = {Dichotomous thinking dominates the field of synthetic photochemistry—either a reaction needs a photocatalyst or not. Herein, we report the identification of a photoredox autocatalytic pathway - an alternative to the existing mechanistic paradigms - to access cyclic biaryl sulfonamides (BASNs). This reaction does not require exogenous catalyst as the visible light absorbing deprotonated product - with potent excited state reductive power - acts as the photocatalyst for its own synthesis. This finding implicated BASN as a novel organophotocatalyst architecture and allowed a rapid, modular, and low-cost combinatorial synthesis of a BASN library that expedited optimal photocatalyst screening. Furthermore, BASN was revealed as a widely applicable organophotocatalyst for diverse transition metal-free transformations such as: intramolecular (spiro)-cyclizations, defunctionalizations, and C−C / C-heteroatom couplings.}, archive = {J_ANGEW}, author = {Jaspreet Kaur and Mark John P. Mandigma and Nakul Abhay Bapat and Joshua P. Barham}, doi = {10.1002/anie.202423190}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202423190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoredox autocatalysis: Towards a library of generally applicable sulfonamide reductive photocatalysts}, volume = {64}, year = {2025}, }
• (2025). “Crystallinity wave”-driven synthesis of hollow multi-shell covalent organic frameworks for enhanced supercapacitors. ANGEW, 64(22), e202423088. (www)

  @article{ , abstract = {Hollow multi-shell covalent organic frameworks (COFs) with abundant modular interfaces, high loading capacity, and various microenvironments are expected to hold great potential for chemical separation, heterogeneous catalysis, and energy storage/conversion. However, the synthetic methodology of COF hollow multi-shell nanoarchitectures has not been established. Herein, we demonstrate an ingenious “crystallinity wave”-induced regional difference ripening strategy to synthesize a series of hollow multi-shell COF particles with controllable shell numbers and shell thickness. The methodology relies on the isolation effect of the local crystalline COF thin layer inserted between the two layers of amorphous covalent organic polymer by the short-time Ostwald ripening, so that different regions of the particles exhibit distinct reaction stages before reaching chemical equilibrium in the subsequent dynamic imine exchange reaction, and then regions that tend to hydrolyze dissolve during the complete ripening process to form a hollow multi-shell structure. Remarkably, this strategy can be extended to prepare other hollow multi-shell COFs by altering monomers. As a proof-of-concept application, the obtained hollow multi-shell COFs are used as the electrode materials for supercapacitor. Benefiting from the short mass transfer path of the hollow multi-shell structure, ordered channels of the COF, and their high surface area, the as-prepared particles exhibit remarkably enhanced specific capacitance.}, archive = {J_ANGEW}, author = {Yuanbo Sun and Bin Zhao and Ji Han and Guangrui Chen and Ruigang Sun and Chengyue Yang and Zhaohui Shi and Bohan Liu and Wenbin Tu and Shanshan Li and Benzheng Li and Guiyuan Zhong and Song Lin Zhang and Wei Feng and Dan Wang and Buyuan Guan}, doi = {10.1002/anie.202423088}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202423088}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Crystallinity wave”-driven synthesis of hollow multi-shell covalent organic frameworks for enhanced supercapacitors}, volume = {64}, year = {2025}, }
• (2025). Enzyme-activated orthogonal proteolysis chimeras for tumor microenvironment-responsive immunomodulation. ANGEW, 64(22), e202423057. (www)

  @article{ , abstract = {Precise modulation of dynamic and complex tumor microenvironment (TME) to disrupt tumorigenesis and reshape intratumoral immune infiltration has emerged as promising approaches for enhanced cancer therapy. Among recent innovations, proteolysis-targeting chimeras (PROTACs) represent a burgeoning chemical knockdown technology capable of degrading oncogenic protein homeostasis and inducing dynamic alternations within carcinoma settings, offering potential for antitumor manipulation. However, achieving selectivity in PROTACs that respond to disease environmental stimulation and precisely perturb on-target proteins remains challenging. The multi-step synthesis and limited permeability, attributed to high-molecular-weight and heterobifunctional structures, further hinder their in vivo efficacy. Herein, we present a unique TME-responsive enzyme-activated clickable PROTACs, which features a short peptide-tagged pomalidomide derivative to undergo tumor-specific cleavage by cathepsin protease to induce orthogonal crosslinking of the exposed cysteine with 2-cyanobenzothiazole-labeled epigenetic protein-ligand JQ1, facilitating in situ degrader formation within tumor regions only. Systematic protein profiling and proteomic analysis revealed that such TME-specific clickable-PROTACs not only selectively eliminate epigenetic proteins without tedious pre-synthesis to bridge disparate small-molecule bi-warhead fragments, but also demonstrated superior tumor penetration compared to conventional high-molecular-weight PROTACs. Importantly, these clickable-PROTACs efficiently downregulated immune checkpoint programmed death-ligand 1 (PD−L1) both in vitro and in vivo, remodeling TME for enhanced therapeutics, especially in anti-tumoral immunomodulation.}, archive = {J_ANGEW}, author = {Caixia Sun and Songhan Liu and Jun Wei Lau and Hanyu Yang and Yun Chen and Bengang Xing}, doi = {10.1002/anie.202423057}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202423057}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzyme-activated orthogonal proteolysis chimeras for tumor microenvironment-responsive immunomodulation}, volume = {64}, year = {2025}, }
• (2025). Stability and mitochondrial localization of a highly cytotoxic Organogold(III) complex with diphosphine ancillary ligand in lung cancer cells. ANGEW, 64(22), e202422763. (www)

  @article{ , abstract = {We present a comprehensive study on the chemical reactivity in the gas phase, with amino acids and peptides, and in the cell, the anticancer activity and localization of a series of seven cationic biphenyl gold(III) complexes with aryl, alkyl, and chiral diphosphine ancillary ligands. Despite some structural differences, all the complexes similarly featured high stability toward reduction or ligand exchange in cell-free conditions. The biphenyl Au(III) complex including the 1,2-diphenylphosphinoethane (dppe) ligand manifested the same high stability in a cellular setting, as attested by a combination of cryo-Synchrotron Radiation-X-Ray Fluorescence (cryo-SR-XRF) nano-imaging and cryo-Synchrotron Radiation-X-ray Absorption Spectroscopy (cryo-SR-XAS) measurements. Tandem cryo-SR-XRF elemental mapping and confocal fluorescence microscopy demonstrated the selective accumulation of the dppe complex in mitochondria. This represents the first study of the speciation and distribution of an organogold(III) complex in cancer cells.}, archive = {J_ANGEW}, author = {Hester Blommaert and Clément Soep and Edwyn Remadna and Héloïse Dossmann and Murielle Salomé and Olivier Proux and Isabelle Kieffer and Jean-Louis Hazemann and Sylvain Bohic and Michèle Salmain and Benoît Bertrand}, doi = {10.1002/anie.202422763}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202422763}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stability and mitochondrial localization of a highly cytotoxic Organogold(III) complex with diphosphine ancillary ligand in lung cancer cells}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of lugdunomycin via sequential photoinduced spiroketalization and isobenzofuran Diels–Alder reactions. ANGEW, 64(22), e202422615. (www)

  @article{ , abstract = {The presence of sterically rigid contiguous quaternary stereocenters in natural products imposes conformational constraints with significant effects on their biological activities. However, achieving the direct synthesis of multiple contiguous quaternary stereocenters in a single step remains a formidable challenge. Here, we present the total synthesis of the antibacterial metabolite lugdunomycin ( 1 ) in thirteen steps via a sequence of photochemical transformations. A photoenolization, keto–enol tautomerization, and spiroketalization sequence was developed to generate the spiroketal 4 from actinaphthoran B ( 3 ). Subsequently, a photoinduced isobenzofuran Diels–Alder reaction between elmonin ( 4 ) and iso -maleimycin ( 5 ) was developed to construct the polycyclic benzaza[4,3,3]propellane framework bearing three contiguous quaternary stereocenters in the compact C-ring along with a distal hydroxyl group at C19. The mechanism of these photochemical reactions was investigated using synthetic and computational approaches.}, archive = {J_ANGEW}, author = {Lei Zhu and Jun Huang}, doi = {10.1002/anie.202422615}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202422615}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of lugdunomycin via sequential photoinduced spiroketalization and isobenzofuran Diels–Alder reactions}, volume = {64}, year = {2025}, }
• (2025). Structure of a DNA-stabilized Ag16Cl2 nanocluster in solution. ANGEW, 64(22), e202422432. (www)

  @article{ , abstract = {We determine the first solution-state structure of a DNA-stabilized Ag 16 Cl 2 nanocluster using X‑ray total scattering and pair distribution function analysis. We find that the structure in solution exhibits both displacive and rotational distortions compared to the known crystal structure. Additionally, our measurements are sensitive toward changes in DNA conformation, revealing that the DNA scaffold in solution exhibits significantly more flexibility than when conformationally locked in the crystalline form. Our results demonstrate the capability to determine the structure of DNA-stabilized clusters beyond their crystallized form, an essential step toward understanding differences between their solution-phase and solid-state photophysical properties.}, archive = {J_ANGEW}, author = {Adam F. Sapnik and Giacomo Romolini and Cecilia Cerretani and Tom Vosch and Kirsten M. Ø. Jensen}, doi = {10.1002/anie.202422432}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202422432}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structure of a DNA-stabilized Ag16Cl2 nanocluster in solution}, volume = {64}, year = {2025}, }
• (2025). Ultrasound-activated theranostic materials and their bioapplications. ANGEW, 64(22), e202422278. (www)

  @article{ , abstract = {Ultrasound (US) is a promising external excitation modality for bioapplications, offering significant advantages over X-rays or lasers due to its low cost, high biosafety, and ideal tissue penetration depth. US-activated theranostic materials, comprising organic, inorganic, and hybrid-based compounds, hold particular value in synergistic cancer therapeutic and diagnostic applications. These materials exhibit excellent imaging properties, high drug delivery and release efficiency, and enhanced reactive oxygen species (ROS) production, making them suitable for clinical diagnostic imaging and therapeutic interventions. This review summarizes recent research on the design, performance, and optimization of US-mediated molecules/nanosystems for a wide range of biomedical applications. Additionally, the multifunctional use of these sonosensitizers in imaging, drug delivery, and sonodynamic therapy, especially in combination with other treatments, could pave the way for innovative strategies in disease therapy. Finally, an overview of this field's challenges and potential future directions is provided, highlighting pathways to promote clinical translation and application.}, archive = {J_ANGEW}, author = {Kang Zhu and Jimei Wang and Zhao Wang and Qing Chen and Jibin Song and Xiaoyuan Chen}, doi = {10.1002/anie.202422278}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202422278}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrasound-activated theranostic materials and their bioapplications}, volume = {64}, year = {2025}, }
• (2025). Gromomycins: An unprecedented class of triterpene antibiotics produced by a novel biosynthetic pathway. ANGEW, 64(22), e202422270. (www)

  @article{ , abstract = {The current situation with drug-resistant microbial pathogens is critical, dictating an acute need for novel efficient antibiotics. Herein, we report a new class of antibiotics named gromomycins with significant activity, especially against drug-resistant Gram-positive pathogens, including methicillin- and daptomycin-resistant Staphylococcus aureus . Gromomycins are pentacyclic triterpenes with a cyclic guanidino group forming the fifth six-membered ring. We have used transposon mutagenesis to identify the gromomycin biosynthetic gene cluster, since it could not be assigned by any available bioinformatics tools, highlighting its unique biosynthetic route. Using gene cluster engineering, feeding experiments, and LC-MS and NMR analyses we have proposed the biosynthetic pathway for gromomycins, which are the first bacterial triterpenes synthesized independently of the squalene pathway. They also exhibit a so far unprecedented cyclization route that utilizes a hexaprenylguanidine linear precursor. Leveraging our understanding of their biosynthesis, we have identified additional gromomycin producers, resulting in the isolation of novel bioactive derivatives.}, archive = {J_ANGEW}, author = {Stepan Tistechok and Dmytro Bratiichuk and Hilda Sucipto and Nils Gummerlich and Marc Stierhof and Oleksandr Gromyko and Franziska Fries and Victor Fedorenko and Rolf Müller and Josef Zapp and Maksym Myronovskyi and Andriy Luzhetskyy}, doi = {10.1002/anie.202422270}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202422270}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gromomycins: An unprecedented class of triterpene antibiotics produced by a novel biosynthetic pathway}, volume = {64}, year = {2025}, }
• (2025). Unraveling the surface chemistry of aluminum oxo archimedean cages for efficient serial adsorption. ANGEW, 64(22), e202421484. (www)

  @article{ , abstract = {Multifunctional materials that meet diverse application needs hold profound significance in resource optimization, efficiency enhancement, and environmental sustainability. However, the development of these materials faces numerous challenges, including raw material acquisition, design feasibility, and long-term stability. This study demonstrates the innovative application of the surface chemistry of aluminum oxo Archimedean cages in efficient serial adsorption. The “Four-in-One” surface chemistry enables various single-crystal-to-single-crystal (SC-SC) structural transformations, involving ligand modification, cation exchange, post-synthetic metalation, and metal elimination, successfully achieving the first reversible SC-SC transformation from cluster structures to infinite frameworks. The fundamental reason behind these dynamic structural changes lies in the exceptional balance between rigidity and flexibility provided by the intercluster tri-pyrazole sites on the Archimedean cages. This diverse structural transformation characteristic offers extensive application potential for solid-liquid and solid-gas serial adsorption. For instance, this material effectively adsorbs heavy metal ions in water treatment and can subsequently be used for the permanent fixation of gaseous radionuclides. This work not only deepens our understanding of dynamic chemistry but also provides guiding significance for environmental remediation.}, archive = {J_ANGEW}, author = {Cheng-Yang Zhang and Zhicheng Wu and Gang Han and Dong-Shuai Wu and Lisheng Chi and Jing-Yang Niu and Chao Zhao and Wei-Hui Fang and Jian Zhang}, doi = {10.1002/anie.202421484}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202421484}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the surface chemistry of aluminum oxo archimedean cages for efficient serial adsorption}, volume = {64}, year = {2025}, }
• (2025). Highly efficient acceptors with a nonaromatic thianthrene central core for organic photovoltaics. ANGEW, 64(22), e202421289. (www)

  @article{ , abstract = {Despite the great role in determining molecular packings and organic photovoltaic outcomes, very rare candidates could be employed as central cores in current high-performance acceptors except diimide-based moieties. Herein, a new type of central core of nonaromatic thianthrene is explored firstly, affording an exotic but structurally tailorable molecular platform for acceptor design. A unique puckered rather than planar conformation of central core is adopted, caused by the 4n πe − feature, great ring strain and largely the insufficient p–π orbital overlap of lone pair on sulfur of thianthrene and coterminous benzene planes. As a result, the absorption of thianthrene-based acceptors (CS1, CS2, and CS3) shows unexpected blue shift comparing to the phenazine-based counterpart (CH20), regardless of the intrinsically strong electron-donating characteristic of low valence sulfur atoms. Even so, the desired molecular packing and fibrillary film morphology, assisted by the suitable chlorination on thianthrene, still contribute to the best device efficiency of 19.0% based on D18:CS2 blends. Such novel work renders an underdeveloped NFA platform with the potentials for achieving PCE of over 20%.}, archive = {J_ANGEW}, author = {Zheng Xu and Xiangjian Cao and Zhaoyang Yao and Wenkai Zhao and Wendi Shi and Xingqi Bi and Yu Li and Yaxiao Guo and Guanghui Li and Guankui Long and Xiangjian Wan and Chenxi Li and Yongsheng Chen}, doi = {10.1002/anie.202421289}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202421289}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient acceptors with a nonaromatic thianthrene central core for organic photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Efficient electrochemical-enzymatic conversion of PET to formate coupled with nitrate reduction over ru-doped Co3O4 catalysts. ANGEW, 64(22), e202421240. (www)

  @article{ , abstract = {Electrochemical reforming presents a sustainable route for the conversion of nitrate (NO 3 − ) and polyethylene terephthalate (PET) into value-added chemicals, such as ammonia (NH 3 ) and formic acid (HCOOH). However, its widespread application has been constrained by low selectivity due to the complexity of reduction processes and thus energy scaling limitations. In this study, the atomically dispersed Ru sites in Co 3 O 4 synergistically interact with Co centers, facilitating the adsorption and activation of hydroxyl radicals (OH * ) and ethylene glycol (EG), resulting in a remarkable HCOOH selectivity of 99% and a yield rate of 11.2 mmol h −1 cm −2 surpassing that of pristine Co 3 O 4 (55% and 3.8 mmol h −1 cm −2 ). Furthermore, when applied as a bifunctional cathode catalyst, Ru-Co 3 O 4 achieves a remarkable Faradaic efficiency (FE) of 98.5% for NH 3 production (3.54 mmol h −1 cm −2 ) at -0.3 V versus RHE. Additionally, we developed a prototype device powered by a commercial silicon photovoltaic cell, enabling on-site solar-driven production of formate and NH 3 through enzyme-catalyzed PET and NO 3 − conversion. This study offers a viable approach for waste valorization and green chemical production, paving the way for sustainable energy applications.}, archive = {J_ANGEW}, author = {Jiadi Jiang and Leting Zhang and Guanzheng Wu and Jianrui Zhang and Yidong Yang and Wenhui He and Jun Zhu and Jian Zhang and Qing Qin}, doi = {10.1002/anie.202421240}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202421240}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient electrochemical-enzymatic conversion of PET to formate coupled with nitrate reduction over ru-doped Co3O4 catalysts}, volume = {64}, year = {2025}, }
• (2025). Molecular stiffening by macrocycle clustering. ANGEW, 64(22), e202420880. (www)

  @article{ , abstract = {Allosteric stiffening of a portion of a protein surface is a strategy used in nature to regulate protein oligomerization and provide crucial functions for cells. However, a similar strategy to selectively control part of a compound dynamics remains elusive. Here we show that cucurbit[ n ]uril (CB[ n ]) macrocycles can bind almost all portions of a tetratopic guest molecule, stiffening the different parts of the guest to different extents. “Host–guest” interactions were found to be instrumental in selectively “freezing” guest molecular motions. The combination of 1 H-NMR (1D, 2D), DOSY, VT-NMR, isothermal titration calorimetry (ITC), mass spectrometry and molecular modelling enabled to highlight the crucial role of cucurbit[8]uril (CB[8]) binding in the selective hardening of relevant portions of the guest molecule. Beyond implications for bioinspired systems mimicking control of a system dynamic to create a new function, this approach has relevance for improving room temperature phosphorescence, and could also be used to allosterically control organocatalysis in water.}, archive = {J_ANGEW}, author = {Hang Yin and Qian Cheng and Roselyne Rosas and Stéphane Viel and Valerie Monnier and Laurence Charles and Didier Siri and Didier Gigmes and Mehdi Yemloul and Ruibing Wang and Anthony Kermagoret and David Bardelang}, doi = {10.1002/anie.202420880}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202420880}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular stiffening by macrocycle clustering}, volume = {64}, year = {2025}, }
• (2025). Amphiphilic zeolitic imidazolate framework for improved CO2 separation in PIM-1 mixed matrix membranes. ANGEW, 64(22), e202420879. (www)

  @article{ , abstract = {This study aims to enhance the compatibility between filler and polymer in mixed matrix membranes (MMMs), addressing an important challenge in membrane development. ZIF-94, known for its affinity to CO 2 , was partially modified with 2-undecylimidazolate (umIm) through the solvent-assisted ligand exchange (SALE) method to improve its compatibility with the prototypical polymer of intrinsic microporosity PIM-1. The modified ZIF-94 (ZIF-94-umIm) can be considered as an amphiphilic MOF with both hydrophilic and hydrophobic moieties, while maintaining a considerably high CO 2 adsorption capacity (2.34 mmol g −1 at 90 kPa and 0 °C). Gas separation experiments were performed using mixed gas compositions of 15/85 CO 2 /N 2 at 3 bar and 35 °C. The resulting MMM with a 5 wt.% loading exhibited an enhanced CO 2 separation performance, with ca. 70% and 10% increases in CO 2 permeability (8900 Barrer) and CO 2 /N 2 selectivity (20.2), respectively, compared to pristine PIM-1 membranes. In addition, thin film nanocomposite membranes were prepared showing a 23.5 CO 2 /N 2 selectivity at 2350 GPU of CO 2 . This modification strategy shows a great potential for improving the CO 2 capture technologies, highlighting the potential of tailoring MOF fillers for advanced membrane materials in gas separation applications.}, archive = {J_ANGEW}, author = {Marta Pérez-Miana and José Miguel Luque-Alled and Álvaro Mayoral and Íñigo Martínez-Visus and Andrew B. Foster and Peter M. Budd and Joaquín Coronas}, doi = {10.1002/anie.202420879}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202420879}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amphiphilic zeolitic imidazolate framework for improved CO2 separation in PIM-1 mixed matrix membranes}, volume = {64}, year = {2025}, }
• (2025). Role of interfacial water in improving the activity and stability of lattice-oxygen-mediated acidic oxygen evolution on RuO2. ANGEW, 64(22), e202420848. (www)

  @article{ , abstract = {Although RuO 2 -based electrocatalysts have been widely studied for acidic oxygen evolution reaction (OER), triggering the conventional adsorbate evolution mechanism to suppress kinetically favorable lattice oxygen mechanism (LOM) pathway at the expense of activity is the state-of-the-art strategy. To date, approaches to simultaneously achieve remarkable activity and stability of RuO 2 -based electrocatalysts through the kinetically favorable LOM pathway toward acidic OER are still elusive. Herein, we report that RuS 0.45 O x catalyst with the synergetic regulation of asymmetric S–Ru–O microstructure and Ru–SO 4 local environments can simultaneously boost the lattice-oxygen-mediated OER activity and stability under acidic electrolyte. Experimental results, including operando attenuated total reflectance surface-enhanced infrared absorption spectroscopy, operando X-ray photoelectron spectroscopy, and theoretical studies, indicate the dynamic evolution of interfacial water structure from hydrogen-bond water to free-H 2 O on the surface of RuS 0.45 O x . The generated continuous free-H 2 O-enriched local environment is in favor of accelerating the sluggish kinetics of interfacial water dissociation and facilitating the replenishment of lattice oxygen vacancies generated during the lattice-oxygen-mediated OER process, thereby significantly enhancing the stability. Consequently, the obtained RuS 0.45 O x displays remarkable acidic OER performance with 160 mV to reach 10 mA cm −2 , and robust stability with negligible activity decay over 500 h at 100 mA cm −2 .}, archive = {J_ANGEW}, author = {Liqing Wu and Wenxia Huang and Dongyang Li and Bingbing Zhao and Haiqing Zhou and Wei Luo}, doi = {10.1002/anie.202420848}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202420848}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Role of interfacial water in improving the activity and stability of lattice-oxygen-mediated acidic oxygen evolution on RuO2}, volume = {64}, year = {2025}, }
• (2025). Online coupling high-temperature electrolysis with carbonylation reactions: A powerful method for continuous carbon dioxide utilization. ANGEW, 64(22), e202420578. (www)

  @article{ , abstract = {Despite being widely available, the broad utilization of CO 2 for chemical production remains in its infancy. The difficulty of using CO 2 as an important resource for the chemical industry lies in the high stability of the molecule and its associated inertia. In this work, we demonstrate how to overcome these limitations by utilizing a solid oxide electrolysis cell (SOEC) with an optimized cathode to produce dry CO through the high-temperature electrolysis of CO 2 . We further integrate this process with a synthesis setup in a continuous-flow coil reactor to boost reactivity in various carbonylation processes, including in amino-, alkoxy-, and phenoxycarbonylation, carbonylative Sonogashira couplings, or the synthesis of redox-active esters. Ultimately, our approach offers a platform strategy for the rapid, scalable, and continuous production of carbonyl compounds directly from CO 2 while eliminating the requirement for storing large CO quantities.}, archive = {J_ANGEW}, author = {Kristof Stagel and Kirsten Rath and Prasad M. Kathe and Michael Schnürch and Tobias M. Huber and Alexander K. Opitz and Katharina Bica-Schröder}, doi = {10.1002/anie.202420578}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202420578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Online coupling high-temperature electrolysis with carbonylation reactions: A powerful method for continuous carbon dioxide utilization}, volume = {64}, year = {2025}, }
• (2025). Improving internal exciton confinement for efficient CdZnSeS-based blue quantum dot light-emitting diodes. ANGEW, 64(22), e202420421. (www)

  @article{ , abstract = {Quantum-dot light-emitting diodes (QLEDs) are thought to be the base for next-generation display technology. However, the performance of blue-emitting QLEDs still falls behind those of green and red ones, which can be attributed to the energy loss from Auger recombination and the strong coupling of excitons with surface states. Blue quantum dots (QDs) with giant CdZnSeS alloy cores are expected to improve the internal confinement of excitons due to the nonmonotonical energy landscape of their conduction band, while they haven't shown high performance in QLEDs due to insufficient optimization of their shell structures. In this work, giant CdZnSeS alloy cores were synthesized by diffusing Zn atoms into CdSeS cores, so that the core/shell lattice stress was released due to the optimized gradient compositions. As a result, exciton transfer and Auger recombination are both suppressed, leading to a breakthrough external quantum efficiency (EQE) of 24% in blue QLEDs with giant CdZnSeS alloy cores. Compared to the more extensively studied blue quantum dots with CdSeZn alloy cores, blue QLEDs with giant CdZnSeS alloy cores also benefit from the suppressed Fermi level and nonmonotonical energy landscape of the conduction band minimum (CBM), which are crucial for confining the wavefunctions of the excitons. The improved exciton confinement explained the superior performances of giant CdZnSeS alloy cores over CdSeZn cores in blue QLEDs.}, archive = {J_ANGEW}, author = {Xiaoting Yang and Wenjing Zhang and Yicheng Zeng and Yihuang Chong and Fangze Liu and Zhenghui Wu and Huaibin Shen and Hongbo Li}, doi = {10.1002/anie.202420421}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202420421}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving internal exciton confinement for efficient CdZnSeS-based blue quantum dot light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). P-type TiO2 nanotubes: Quantum confinement and pt single atom decoration enable high selectivity photocatalytic nitrate reduction to ammonia. ANGEW, 64(22), e202415865. (www)

  @article{ , abstract = {We synthesize p-type TiO 2 nanotubes that allow band-gap adjustment by quantum confinement. These tubes therefore enable reductive photocatalytic reactions that are not thermodynamically possible on classic titania photocatalysts. Here, we demonstrate the direct photocatalytic nitrate reduction to ammonia without any need of hole scavengers. The quantum confinement effect (and thus the thermodynamic driving force) can be controlled by the thickness of the nanotube walls. Notably, the use of Pt single atoms as cocatalysts decorated on the TiO 2 nanotubes additionally offers a superior ammonia production and a remarkable enhanced selectivity compared to Pt nanoparticles. Overall, the work not only highlights the potential of size-controlled modifications of electronic properties in extending the utility of a most classical photocatalyst but also exemplifies its use in technologically relevant reactions.}, archive = {J_ANGEW}, author = {Hayoon Jung and Hyesung Kim and Johannes Will and Erdmann Spiecker and Patrik Schmuki}, doi = {10.1002/anie.202415865}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {22}, pages = {e202415865}, shortjournal = {Angew. Chem. Int. Edit.}, title = {P-type TiO2 nanotubes: Quantum confinement and pt single atom decoration enable high selectivity photocatalytic nitrate reduction to ammonia}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: PH-dependent switching between nonlinear-optical-active nitrate-based supramolecular polymorphs. ANGEW, 64(21), e202582101. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202582101}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202582101}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: PH-dependent switching between nonlinear-optical-active nitrate-based supramolecular polymorphs}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Exploring the mechanism of surface cationic vacancy induces high activity of metastable lattice oxygen in li- and mn-rich cathode materials (Angew. chem. int. ed. 21/2025). ANGEW, 64(21), e202508980. (www)

  @article{ , archive = {J_ANGEW}, author = {Tian Zhao and Jilu Zhang and Kai Wang and Yao Xiao and Qin Wang and Longfei Li and Jochi Tseng and Meng-Cheng Chen and Jian-Jie Ma and Ying-Rui Lu and Ishii Hirofumi and Yu-Cheng Shao and Xiaoxian Zhao and Sung-Fu Hung and Yaqiong Su and Xiaoke Mu and Weibo Hua}, doi = {10.1002/anie.202508980}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202508980}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Exploring the mechanism of surface cationic vacancy induces high activity of metastable lattice oxygen in li- and mn-rich cathode materials (Angew. chem. int. ed. 21/2025)}, volume = {64}, year = {2025}, }
• (2025). Front cover: Halogen bonding as a tool to control morphology and charge (Angew. chem. int. ed. 21/2025). ANGEW, 64(21), e202508978. (www)

  @article{ , archive = {J_ANGEW}, author = {Tero-Petri Ruoko and Marc-Antoine Stoeckel and Rakesh Puttreddy and Chi-Yuan Yang and Silan Zhang and Ziang Wu and Nuno R. Candeias and Paolo Samorì and Han Young Woo and Simone Fabiano and Arri Priimagi}, doi = {10.1002/anie.202508978}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202508978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Front cover: Halogen bonding as a tool to control morphology and charge (Angew. chem. int. ed. 21/2025)}, volume = {64}, year = {2025}, }
• (2025). Chularat wattanakit. ANGEW, 64(21), e202507242. (www)

  @article{ , archive = {J_ANGEW}, author = {Chularat Wattanakit}, doi = {10.1002/anie.202507242}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202507242}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chularat wattanakit}, volume = {64}, year = {2025}, }
• (2025). Sarah guerin. ANGEW, 64(21), e202506912. (www)

  @article{ , archive = {J_ANGEW}, author = {Sarah Guerin}, doi = {10.1002/anie.202506912}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202506912}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sarah guerin}, volume = {64}, year = {2025}, }
• (2025). Correction to “Alcohols as alkylating agents: Photoredox-catalyzed conjugate alkylation via in situ deoxygenation”. ANGEW, 64(21), e202506694. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202506694}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202506694}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Correction to “Alcohols as alkylating agents: Photoredox-catalyzed conjugate alkylation via in situ deoxygenation”}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Accelerated destruction of passive film and microbial corrosion of 316L stainless steel via extracellular electron transfer (Angew. chem. int. ed. 21/2025). ANGEW, 64(21), e202506307. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhong Li and Jie Wang and Feng Li and Zhengtao Li and Enze Zhou and Yongqiang Fan and Hao Song and Zhaodong Xu and Tingyue Gu and Fuhui Wang and Dake Xu}, doi = {10.1002/anie.202506307}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202506307}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Accelerated destruction of passive film and microbial corrosion of 316L stainless steel via extracellular electron transfer (Angew. chem. int. ed. 21/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Nanopore confinement-driven synchronous enhancement of thermal and mechanical properties of phase change materials (Angew. chem. int. ed. 21/2025). ANGEW, 64(21), e202506109. (www)

  @article{ , archive = {J_ANGEW}, author = {Lin Qiu and Zhaoyi Wang and Zihan Liu and Haimo Li and Yanhui Feng}, doi = {10.1002/anie.202506109}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202506109}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Nanopore confinement-driven synchronous enhancement of thermal and mechanical properties of phase change materials (Angew. chem. int. ed. 21/2025)}, volume = {64}, year = {2025}, }
• (2025). Stable Cobalt–Zeolite propane-dehydrogenation catalysts enabled by reaction-driven reconstruction. ANGEW, 64(21), e202505628. (www)

  @article{ , abstract = {Cobalt-based catalysts have emerged as promising substitutes for Pt- and Cr-based propane dehydrogenation (PDH) catalysts. However, controlling the distribution of Co species and achieving stable active centers remains challenging. Here, we report that reaction-driven reconstruction of metallic cobalt (Co 0 ) species within pure silica MFI zeolite (S-1) into CoO x clusters within silanol nests during PDH yields efficient and durable performance. Atomically dispersed CoO x clusters exhibit exceptional durability and high propylene space-time yield (STY), maintaining an ultrahigh propylene STY of 17.2 mmol C3H6 g cat −1 h −1 for over 260 h under industrially relevant conditions, surpassing previous cobalt-based PDH catalysts. Moreover, the catalyst operates stably at 520 °C for 170 h with near-equilibrium propane conversions. Comprehensive characterizations indicate the dynamic evolution process from the silanol nests effectively capturing and stabilizing Co 0 species within S-1 zeolite, thereby promoting the dynamic formation of CoO x clusters during the PDH process. We also demonstrate that stable Co─O active centers formed by this unique anchoring strategy improve catalyst stability by suppressing coke formation and promoting efficient propane dehydrogenation.}, archive = {J_ANGEW}, author = {Qiang Liu and Yongbin Yao and Junmeng Li and Jingnan Wang and Lili Chen and Wenlin Li and Yangyang Guo and Siyu Yao and Yongan Yang and Xi Wang}, doi = {10.1002/anie.202505628}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202505628}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable Cobalt–Zeolite propane-dehydrogenation catalysts enabled by reaction-driven reconstruction}, volume = {64}, year = {2025}, }
• (2025). Tuning Ru–O coordination for switching redox centers in acidic oxygen evolution electrocatalysis. ANGEW, 64(21), e202504876. (www)

  @article{ , abstract = {Avoiding lattice oxygen involvement (oxygen redox) while promoting the coupling of adjacent adsorbed oxygen (metal redox) during the acidic oxygen evolution reaction (OER) is essential for gaining high activity and robust stability in RuO 2 -based catalysts but remains elusive. Here, we present a precise strategy to selectively activate the metal redox process while suppressing the undesired oxygen redox pathway by fine-tuning the Ru–O coordination number in amorphous RuO x . The optimized catalyst exhibits outstanding acidic OER performance, achieving a low overpotential of 215 mV at 10 mA cm −2 and maintaining stability for 300 h with a negligible degradation rate of 100 µV h −1 . X-ray absorption measurements and multiple operando spectra reveal that only Ru 2 –O 11 moieties can selectively activate the metal redox process, whereas Ru 2 –O 9 and Ru 2 –O 8 moieties either trigger both redox pathways or bypass them. Theoretical calculations reveal that Ru 2 –O 11 moiety reduces crystal field splitting energy at active Ru sites, disables lattice oxygen activation, and lowers the energy barrier for oxygen coupling. The strategy developed in this work offers new avenues for switching redox centers and refining OER mechanisms to enhance catalytic performance and long-term stability.}, archive = {J_ANGEW}, author = {Yajing Mu and Jinchang Fan and Tianyi Gao and Lina Wang and Lei Zhang and Xiaoxin Zou and Weitao Zheng and Yong-Wei Zhang and Zhi Gen Yu and Xiaoqiang Cui}, doi = {10.1002/anie.202504876}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504876}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning Ru–O coordination for switching redox centers in acidic oxygen evolution electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Using host-guest chemistry to examine the effects of porosity and catalyst-support interactions on CO2 reduction. ANGEW, 64(21), e202504630. (www)

  @article{ , abstract = {Bis-porphyrin nanocages ( M 2 BiCage , M = FeCl, Co, Zn) and their host-guest complexes with C 60 and C 70 were used to examine how molecular porosity and interactions with carbon nanomaterials affect the CO 2 reduction activity of metalloporphyrin electrocatalysts. The cages were found to adsorb on carbon black to provide electrocatalytic inks with excellent accessibilities of the metal sites (≈50%) even at high metal loadings (2500 nmol cm −2 ), enabling good activity for reducing CO 2 to CO. A complex of C 70 bound inside (FeCl) 2 BiCage achieves high current densities for CO formation at low overpotentials (| j CO | >7 mA cm −2 , η = 320 mV; >13.5 mA cm −2 , η = 520 mV) with ≥95% Faradaic efficiency (FE CO ), and Co 2 BiCage achieves high turnover frequencies (≈1300 h −1 , η = 520 mV) with 90% FE CO . In general, blocking the pore with C 60 or C 70 improves the catalytic performance of (FeCl) 2 BiCage and has only small effects on Co 2 BiCage , indicating that the good catalytic properties of the cages cannot be attributed to their internal pores. Neither enhanced electron transfer rates nor metal-fullerene interactions appear to underlie the ability of C 60 /C 70 to improve the performance of (FeCl) 2 BiCage , in contrast to effects often proposed for other carbon nanosupports.}, archive = {J_ANGEW}, author = {Daniel A. Rothschild and Zeyu Cao and Feng Xie and Belvin Thomas and Thomas J. Emge and Jing Li and Tewodros Asefa and Mark C. Lipke}, doi = {10.1002/anie.202504630}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504630}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Using host-guest chemistry to examine the effects of porosity and catalyst-support interactions on CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Stereochemistry at the single-molecule level: From monitoring to regulation. ANGEW, 64(21), e202504558. (www)

  @article{ , abstract = {Traditional stereochemistry analysis is crucial for understanding the molecular behavior, but relies on measurements that encompass multiple molecules and obscure individual molecular dynamics. Single-molecule techniques enable real-time tracking of stereochemical transformations. These techniques include electrical methods (such as scanning probe microscopy, single-molecule junction techniques, and nanopore technology) and non-electrical approaches (such as circular dichroism spectroscopy and surface-enhanced Raman spectroscopy). This review highlights recent advances in monitoring and regulation of stereochemical properties at the single-molecule level. Techniques that bridge macroscopic observations with molecular-scale dynamics are emphasized. Key isomerization phenomena (constitutional, configurational, and conformational isomerizations) are explored to demonstrate how light, electric field, and mechanical force regulate molecular states. The use of chiral molecules in optical tweezers, chiral-modified scanning tunneling microscopies, and graphene-based single-molecule junctions to leverage the chirality-induced spin selectivity effect for enantiomer discrimination and manipulation is highlighted. Despite progress in this field, challenges persist in resolving ultrafast isomerization pathways, understanding chiral origin mechanisms, and integrating single-molecule devices. Emerging strategies combining multimodal stimuli, machine learning, and nanofabrication are promising for advancing stereochemical research and applications in molecular electronics and nanotechnology. This work underscores the transformative potential of single-molecule techniques in unveiling fundamental chemical dynamics and designing functional molecular systems.}, archive = {J_ANGEW}, author = {Wenlong Cai and Xinmiao Xie and Zezhou Yang and Xuefeng Guo}, doi = {10.1002/anie.202504558}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504558}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereochemistry at the single-molecule level: From monitoring to regulation}, volume = {64}, year = {2025}, }
• (2025). A self-catalysis system coupled with redox mediator effect for ultra-long cycle life li-o2 batteries. ANGEW, 64(21), e202504554. (www)

  @article{ , abstract = {The sluggish kinetics of Li-O 2 batteries significantly limit their performance. To address this issue, the insulating characteristics of the discharge product Li 2 O 2 and the reactivity of highly active superoxide species are examined. Herein, organic metal salts with weak electrolyte properties are utilized as bifunctional additives. The ionized metal ions can be reduced and doped Li 2 O 2 through in situ electrochemical implantation, thereby altering its insulating properties. Additionally, organic metal salts function as redox mediators (RMs), stabilizing the intermediate LiO 2 and facilitating its further disproportionation to Li 2 O 2 , as well as enhancing the decomposition reaction during charging, which are further proven by the in situ X-ray absorption spectroscopy and UV–vis spectroscopy. Notably, Li-O 2 batteries incorporating Mn(acac) 3 demonstrate an ultra-low overpotential of 0.43 V and sustain 250 long cycles at 1000 mA g −1 . Furthermore, when combined with the optimized cathode, a remarkable cycle stability of 3850 cycles at 1000 mA g −1 is achieved. These findings offer novel insights into the design of advanced Li-O 2 battery systems and the enhancement of their performance.}, archive = {J_ANGEW}, author = {Xingzi Zheng and Mengwei Yuan and Peiyuan Su and Qingyu Kong and Jingshen Xu and Genban Sun}, doi = {10.1002/anie.202504554}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504554}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A self-catalysis system coupled with redox mediator effect for ultra-long cycle life li-o2 batteries}, volume = {64}, year = {2025}, }
• (2025). Highly efficient and durable anode catalyst layer constructed with deformable hollow IrOx nanospheres in low-iridium PEM water electrolyzer. ANGEW, 64(21), e202504531. (www)

  @article{ , abstract = {Reducing iridium packing density (g Ir cm −3 electrode) represents a critical pathway to lower geometric Ir loading in proton exchange membrane water electrolyzers (PEMWEs), yet conventional approaches often cause performance issues of anode catalyst layer due to decreased structural stability and limited electron/mass transport efficiency. Here, we present deformable hollow IrO x nanospheres ( dh -IrO x ) as a structural-engineered catalyst architecture that achieves an ultralow Ir packing density (20% of conventional IrO 2 nanoparticle-based electrodes) while maintaining high catalytic activity and durability at reduced Ir loadings. Scalable synthesis of dh -IrO x via a hard-template method—featuring precise SiO 2 nanosphere templating and conformal Ir(OH) 3 coating—enables batch production of tens of grams. Through cavity dimension and shell thickness optimization, dh -IrO x demonstrates excellent mechanical resilience to necessary electrode fabrication stresses, including high-shear agitation, ultrasonic processing and hot-pressing. In the anode catalyst layer, the quasi-ordered close packing of dh -IrO x nanospheres simultaneously maximizes electrochemically active surface area, suppresses particle migration and agglomeration, and establishes percolated electron highways and rapid mass transport channels. The architected anode delivers high PEMWE performance (e.g., 1 A cm −2 @1.60 V and 2 A cm −2 @1.75 V@80 °C), while demonstrating excellent operational durability with <1.5% voltage loss over 3000 h.}, archive = {J_ANGEW}, author = {Ke Sun and Xiao Liang and Xiyang Wang and Yimin A. Wu and Subhajit Jana and Yongcun Zou and Xiao Zhao and Hui Chen and Xiaoxin Zou}, doi = {10.1002/anie.202504531}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504531}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient and durable anode catalyst layer constructed with deformable hollow IrOx nanospheres in low-iridium PEM water electrolyzer}, volume = {64}, year = {2025}, }
• (2025). Switchable divergent photocatalytic C-glycosylation of glycosyl benzoates. ANGEW, 64(21), e202504504. (www)

  @article{ , abstract = {Metabolically robust C -glycosides are crucial in various biological and medical applications, underscoring the need for efficient synthesis methods. While radical C -glycosylation reactions are known for their reliability and functional group tolerance, challenges such as glycosyl donor stability and atom economy persist. In this study, we investigate the underexplored potential of condition-controlled divergent synthesis of C -glycosides through a switchable photocatalytic C -glycosylation strategy, involving reductive anomeric C─O bond cleavage. Utilizing simple, readily available, and bench-stable glycosyl benzoates as novel O -based glycosyl radical precursors, we successfully achieve deoxygenative glycosylation of simple alkenes and styryl boronic acids, establishing a versatile platform for C -glycoside synthesis. A critical aspect of the challenging reductive cleavage of these benzoate esters is the introduction of strong single-electron transfer (SET) reductants, combined with Brønsted acids to accelerate fragmentation following substrate reduction. Notably, CO 2 •− , generated via the consecutive photon-induced electron transfer process, is utilized for the first time in glycosylation reactions. By meticulously tuning the reaction conditions, including photocatalysts and formate additives, we facilitate the divergent synthesis of alkyl and alkenyl C -glycosides with good to high stereoselectivity and yields. Mechanistic studies provide insight into the reaction pathway and the underlying rationale behind this finely tuned, easily controlled photocatalytic system.}, archive = {J_ANGEW}, author = {Yang Han and Xiaoling Wang and Qiang Tao and Bo Yang and Feng Zhu}, doi = {10.1002/anie.202504504}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504504}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switchable divergent photocatalytic C-glycosylation of glycosyl benzoates}, volume = {64}, year = {2025}, }
• (2025). Metal-free electrochemical C─H chlorination of terminal alkanes. ANGEW, 64(21), e202504478. (www)

  @article{ , abstract = {Although research on the activation of C─H bonds in alkanes has been ongoing for decades, there are still few strategies that are both highly selective and suitable for industrial production. Herein, we report a highly selective method for the chlorination of terminal C─H bonds in alkanes by combining electrochemistry and organocatalysis. The specific cavity size of organic molecular catalysts ensures high regioselectivity, while the use of inexpensive and readily reusable graphite felt electrodes, a simple electrochemical device, and mild conditions enables the reaction to maintain good efficiency even when applied to kilogram-scale production.}, archive = {J_ANGEW}, author = {Qingxu Wang and Pengkai Fang and Jianyou Zhao and Xianting Huang and Xiaoqian Shen and Fan Wang and Zhong-Quan Liu}, doi = {10.1002/anie.202504478}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504478}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-free electrochemical C─H chlorination of terminal alkanes}, volume = {64}, year = {2025}, }
• (2025). Biaryl phosphates and phosphonates as selective inhibitors of the transcription factor STAT4. ANGEW, 64(21), e202504420. (www)

  @article{ , abstract = {The transcription factor STAT4 has been implicated in the pathogenesis of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes mellitus. Here, we report p -biaryl phosphates and phosphonates as the first small-molecule inhibitors of STAT4. The most potent p -biaryl phosphate inhibited the protein–protein interaction domain of STAT4, the SH2 domain, with submicromolar potency ( K i = 0.35 µM) and 14-fold selectivity over the closely related family member STAT3, which has the same core peptide binding motif as STAT4. Further development resulted in the phosphatase-stable inhibitor Stafori-1, which protected STAT4 but not STAT3, against thermal denaturation in cell lysates. Its cell-permeable prodrug Pomstafori-1 selectively inhibited STAT4 phosphorylation in cultured human cells at low micromolar concentrations. Our data open up the possibility of exploring STAT4 as a target protein for small molecules in the treatment of unmet medical needs.}, archive = {J_ANGEW}, author = {Nadiya Brovchenko and Angela Berg and Sabine Schubert and Julian Gräb and Theresa Münzel and Christoph Protzel and Kalaiselvi Natarajan and Thorsten Berg}, doi = {10.1002/anie.202504420}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504420}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biaryl phosphates and phosphonates as selective inhibitors of the transcription factor STAT4}, volume = {64}, year = {2025}, }
• (2025). PPh3/Isocyanide and N2/Isocyanide exchange: Pathways to isolable alkali metal keteniminyl anions. ANGEW, 64(21), e202504325. (www)

  @article{ , abstract = {Keteniminyl anions hold significant promise for advancing ketenimine chemistry, yet their isolation has remained elusive until now. Drawing inspiration from recent advances in ligand exchange reactions at carbon, we report the successful synthesis of a series of isolable alkali metal keteniminyl anions through substitution of the phosphine ligand in metalated ylides or the N₂ ligand in diazomethanides with isocyanides. The exchange reactions were found to proceed more rapidly with aryl isocyanides than with the more electron-rich alkyl-substituted derivatives and were also more efficient when starting from the diazo compounds. The resulting keteniminyl anions exhibit bent geometries, which can be attributed to a donor–acceptor interaction with the isocyanide, giving rise to a carbone-like structure. Electron-withdrawing substituents on the nitrogen enhance backbonding, thus leading to larger bending angles and a more pronounced ynamide character as also evidenced by a blue-shifted ketenimine stretch in the IR spectrum. The keteniminyl anions react efficiently with unsaturated compounds to form a diverse array of heterocycles, highlighting their potential as versatile building blocks in synthetic chemistry.}, archive = {J_ANGEW}, author = {Sunita Mondal and Yihao Zhang and Prakash Duari and Kai-Stephan Feichtner and Arpan Das and Lili Zhao and Gernot Frenking and Viktoria H. Gessner}, doi = {10.1002/anie.202504325}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504325}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PPh3/Isocyanide and N2/Isocyanide exchange: Pathways to isolable alkali metal keteniminyl anions}, volume = {64}, year = {2025}, }
• (2025). Identification, characterization, and catalytic mechanism of regioselective UbiA prenyltransferases in morus plants. ANGEW, 64(21), e202504190. (www)

  @article{ , abstract = {UbiA prenyltransferases (PTs) play an indispensable role in the prenylation of plant metabolites, yielding numerous natural products with enhanced pharmacological activities, such as cannabinoids, polycyclic polyprenylated acylphloroglucinols, prenylated flavonoids, and stilbenoids. These enzymes typically target specific carbon atoms or hydroxy groups of aromatic substrates. Despite the recent identification of dozens of plant-derived UbiA PTs, their catalytic mechanism remains poorly understood, particularly regarding the precise control of regioselectivity. In this study, we identified and characterized a total of 10 members that catalyzed the regioselective prenylation and geranylation of moracin substrates through comprehensive analysis of the UbiA superfamily in Morus alba . Molecular dockings, dynamics simulations, and quantum chemical calculations revealed the substrate-induced conformational changes leading to the formation of the hydrophobic reaction pocket, as well as the differential binding between various Ma PTs and moracin M. Additionally, the recognition of prenyl donors by Ma PT27 and the potential mechanism underlying the reversal of regioselectivity induced by different donors are discussed. Finally, structure-based rational mutation altered the site preference from C7 to C5. These findings suggest that the regioselectivity of plant UbiA PTs is governed by both the inherent chemoselectivity of reaction sites and intricate protein–substrate interactions.}, archive = {J_ANGEW}, author = {Shengzhi Liu and Yanxin Tao and Yuchao Zhang and Jiahui Gong and Zerong Wu and Zhao Wang and Zhoujie An and Runjie Shi and Yu Zhao and Eman Shawky and Zhichao Xu and Wei Zhu and Jingkui Tian}, doi = {10.1002/anie.202504190}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identification, characterization, and catalytic mechanism of regioselective UbiA prenyltransferases in morus plants}, volume = {64}, year = {2025}, }
• (2025). Ligand modulation in Metal–Organic frameworks derived regenerable oxygen evolution electrocatalysts. ANGEW, 64(21), e202504148. (www)

  @article{ , abstract = {Metal-organic frameworks (MOFs) are emerging as promising pre-catalysts for the oxygen evolution reaction (OER) in water electrolysis. However, the coordination chemistry of MOF ligands in reconstructed species remains poorly understood, particularly regarding how ligand modulation influences the electronic configurations of catalytic sites. In this study, we present the synthesis of an α -FeOOH coated Ni-catecholate MOF composite (FeOOH@Ni-CAT), which transforms into a ligand-coordinated γ -NiFeOOH active species during OER. Notably, this active species can revert to its stable α -phase counterpart, exhibiting an “easy-to-regenerate” characteristic. Theoretical calculations demonstrate that the ligand significantly enhances the adsorption energies of oxygenic intermediates involved in the OER, while also modulating electronic structures by strengthening bonding states and promoting electron delocalization between active sites and intermediates. As a result, the FeOOH@Ni-CAT pre-catalyst exhibits exceptional OER performance, achieving an ultralow overpotential of 180 mV at 10 mA cm −2 and impressive durability over 384 h (16 days), leveraging the regenerable property. This work advances the understanding of high-performance MOF-based pre-catalysts by elucidating the fundamental mechanisms of structural reconstruction during OER and highlighting the role of ligand modulation in improving OER activity.}, archive = {J_ANGEW}, author = {Xiao Wang and Zheng Peng and Wei Zhou and Xiaokang Chen and Yi Tan and Yi-Fan Huang and Zhi Liu and Wei-Qiao Deng and Hao Wu}, doi = {10.1002/anie.202504148}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202504148}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand modulation in Metal–Organic frameworks derived regenerable oxygen evolution electrocatalysts}, volume = {64}, year = {2025}, }
• (2025). Thermal activation of asymmetry amplification effects in helical Polymer–Metal complexes. ANGEW, 64(21), e202503949. (www)

  @article{ , abstract = {Dynamic helical polymers such as poly(phenylacetylene)s (PPAs) exhibit different asymmetry amplification effects, e.g., helix inversion or screw-sense induction, in the presence of different external stimuli such as temperature, solvents, or metal ions that usually operate independently through interaction with the pendant on the monomer repeating units (m.r.u.). In this work, we will demonstrate that the helical structure of a chiral PPA can be tamed by playing with two different external stimuli such as temperature and metal ions. Thus, when a metal ion salt is delivered to a chloroform solution of a chiral PPA to generate a chiral PPA (m.r.u.)/M n+ complex in a ratio of 1.0/<0.5 mol/mol, a temperature-responsive material is obtained. Interestingly, when the temperature is lowered to about 278–283 K, the metal ion uncomplexes, which recovers the initial helical structure adopted by the PPA. This complexation–decomplexation between the chiral PPA and the metal ions is fully reversible and triggers different asymmetry amplification effects-helix inversion, screw-sense induction or Sergeants-and-Soldiers (SaS), among others—, allowing the creation of a temperature-responsive helical polymer–metal complex (HPMC) from a metal-responsive helical polymer.}, archive = {J_ANGEW}, author = {Manuel Fernández-Míguez and Emilio Quiñoá and Félix Freire}, doi = {10.1002/anie.202503949}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermal activation of asymmetry amplification effects in helical Polymer–Metal complexes}, volume = {64}, year = {2025}, }
• (2025). A d-electron deficient pd trimer for exceptional pyridine hydrogenation activity and selectivity. ANGEW, 64(21), e202503926. (www)

  @article{ , abstract = {The selective hydrogenation of pyridines containing reducible groups such as 2-phenylpyridine (PPY) typically has low yields due to strong nitrogen coordination with the metal as well as nonselective and over-hydrogenation. We report the synthesis of a novel Pd trimer catalyst through confined growth on an ordered mesoporous carrier, characterized by a 0.42 d -electron deficiency to address this challenge. This catalyst achieved a nearly complete conversion of 2-phenylpyridine and selectivity to 2-phenylpiperidine (PPD), maintaining its performance across eight batch cycles and continuous flow in the liquid phase for 800 h with negligible loss of activity or selectivity. We discuss the roles of active sites, including Pd d charge and ensemble structure, in relation to activation entropy, a Hammett study, and the adsorption configuration of the reactant. The exceptional 2-phenylpyridine hydrogenation activity and selectivity are attributed to the adsorption constraint of the pyridyl ring and the stabilization of the negatively charged transition state in the rate-determining step produced by the d -electron deficient Pd trimer.}, archive = {J_ANGEW}, author = {Linlin Duan and Lili Wang and Guohua Yao and Xiaojuan Zhu and Yafei Sun and Fei Lv and Heng Liu and Yang Yang and Lina Li and Yong Luo and Ying Wan}, doi = {10.1002/anie.202503926}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503926}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A d-electron deficient pd trimer for exceptional pyridine hydrogenation activity and selectivity}, volume = {64}, year = {2025}, }
• (2025). Two-color single-molecule blinking ratiometricity: A functional super-resolution imaging approach for resolving lysosomal pH and dynamics. ANGEW, 64(21), e202503916. (www)

  @article{ , abstract = {Fluorescence super-resolution microscopy has enabled nanoscale imaging of intracellular structures, but it remains challenging to simultaneously achieve structural imaging and quantitative functional characterization, such as pH measurement, within the same region. Here, we introduce two-color single-molecule blinking ratiometricity (2C-SMBR), a novel method that integrates structural and functional imaging with single-molecule precision. By loading lysosomes with two pH-dependent spontaneously blinking fluorophores of distinct colors, 2C-SMBR leverages single-molecule localization of either fluorophore to achieve nanoscale structural imaging of lysosomes, whereas the ratiometric analysis of blinking dynamics between the two fluorophores provides quantitative pH measurement at the single-lysosome level. This dual-color ratiometric approach at the single-molecule level enables precise quantification of lysosomal pH with exceptional spatiotemporal resolution. Using 2C-SMBR, we reveal that lysosomal pH is highly heterogeneous at the single-lysosome level, with distinct subpopulations exhibiting diverse pH values. Our measurements show a pH range of 4.0–6.0 within lysosomes, with perinuclear lysosomes averaging a pH of approximately 4.88, whereas peripheral lysosomes average around 5.64. Crucially, 2C-SMBR enables real-time correlation between lysosomal dynamics and pH changes, overcoming a key limitation of super-resolution imaging. This approach not only advances nanoscale organelle characterization but also provides mechanistic insights into lysosomal physiology and function.}, archive = {J_ANGEW}, author = {Qinglong Qiao and Wenting Yin and Xia Wu and Shaowei Wu and Yiyan Ruan and Ning Xu and Jin Li and Zhong-Shuai Wu and Xiaogang Liu and Zhaochao Xu}, doi = {10.1002/anie.202503916}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-color single-molecule blinking ratiometricity: A functional super-resolution imaging approach for resolving lysosomal pH and dynamics}, volume = {64}, year = {2025}, }
• (2025). Enhancing immune responses through modulation of innate cell microenvironments in lymph nodes with virus-mimetic vaccines. ANGEW, 64(21), e202503845. (www)

  @article{ , abstract = {Nanovaccines hold significant promise for the prevention and treatment of infectious diseases. However, the efficacy of many nanovaccines is often limited by inadequate stimulation of both innate and adaptive immune responses. Herein, we explore a rational vaccine strategy aimed at modulating innate cell microenvironments within lymph nodes (LNs) to enhance the generation of effective immune responses. Inspired by the structure and natural infection process of viruses, we developed a versatile antigen and adjuvant co-delivery platform, termed virus-mimetic vaccines (VMVs). Specifically, polyarginine-tagged antigens were noncovalently assembled onto nucleic acid nanogels containing cytosine-phosphate-guanine oligodeoxynucleotide via a salt-bridge zipper mechanism, which can activate Toll-like receptor 9. Upon intramuscular immunization, VMVs effectively drained into the LNs, recruiting and activating multiple innate cells, including CD8 + dendritic cells (DCs), CD103 + DCs, macrophages, plasmacytoid DCs, and neutrophils. This activation modulates the innate cell microenvironments and relocates antigen-presenting cells within LNs, optimizing adaptive immune responses. VMVs induced a robust antigen-specific immune response, characterized by high levels of neutralizing antibodies, augmented memory T cell activity, and enhanced development of germinal center B cells. Together, our findings demonstrate that dynamic modulation of innate cell microenvironments by VMVs leads to optimized generation of both humoral and cellular immunity against infectious diseases.}, archive = {J_ANGEW}, author = {Runping Su and Tingting Yao and Chong Cao and Yaqi Yang and Mingshan Chen and Jianxiao Wu and Yue Zhao and Xiaoxiao Liu and Sha Li and Junqiang Ding and Rong Yang and Shun Shen and Chuan Zhang and Changyou Zhan and Xihui Gao}, doi = {10.1002/anie.202503845}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503845}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing immune responses through modulation of innate cell microenvironments in lymph nodes with virus-mimetic vaccines}, volume = {64}, year = {2025}, }
• (2025). Boosting nonradiative decay of boron difluoride formazanate dendrimers for NIR-II photothermal theranostics. ANGEW, 64(21), e202503718. (www)

  @article{ , abstract = {The development of small molecular dyes excitable in the second near-infrared window (NIR-II, 1000–1700 nm) is crucial for deep-tissue penetration and maximum permissible exposure in cancer photothermal theranostics. Herein, we employed a dendrimer engineering strategy to develop the boron difluoride formazanate (BDF) dye BDF-8OMe for photoacoustic imaging-mediated NIR-II photothermal therapy. BDF-8OMe, characterized by an increased molecular branching degree and extended π-conjugation, exhibited broad absorbance peaked at 905 nm, with the absorption tail extending to 1300 nm. Additionally, reorganization energy calculation, molecular dynamics simulation, and femtosecond transient absorption spectroscopy demonstrated that the multiple identical dendritic units of BDF-8OMe significantly enhanced the molecular motions, enabling the nanoparticles (NPs) to rapidly release 94.4% of the excited state energy through nonradiative decay at a rate of 11.7 ps. Under 1064 nm photoirradiation, BDF-8OMe NPs achieved a high photothermal conversion efficiency of 62.5%, facilitating NIR-II photothermal theranostics. This work highlights the potential of the dendrimer-building strategy in developing NIR-II excitable small molecular dyes for efficient photothermal theranostics.}, archive = {J_ANGEW}, author = {Hanming Dai and Jingyi Pan and Jinjun Shao and Kang Xu and Xiaohong Ruan and Anqing Mei and Peng Chen and Lulu Qu and Xiaochen Dong}, doi = {10.1002/anie.202503718}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503718}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting nonradiative decay of boron difluoride formazanate dendrimers for NIR-II photothermal theranostics}, volume = {64}, year = {2025}, }
• (2025). Switching on supramolecular DNA junction binding using a human enzyme. ANGEW, 64(21), e202503683. (www)

  @article{ , abstract = {Non-canonical DNA junction structures are important in human disease and in nucleic acid nanoscience and there is a growing interest in how to bind and modulate them. A key next step is to exert “on command” control over such binding. Herein we develop a new metallo-supramolecular triple-helicate cylinder agent that is inert to DNA junction binding until activated by human enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) and its cofactor nicotinamide adenine dinucleotide phosphate (NADPH). This inactive cylinder bears six flexible arms each with a quinone group at the termini. Reduction by the enzyme leads to all six arms being removed, transforming the inert cylinder into a new and active metallo-supramolecular agent that binds junctions. This gives the ability to “switch-on” DNA junction formation and binding in response to the presence of two external stimuli – a human enzyme overexpressed in many disease states, and NADPH – and absence of inhibitor, giving NAND logic control. Modelling indicates the binding activation originates not in steric unblocking but changes in conformational flexibility. The work provides the foundation for and a route map toward future designs of sophisticated, inert, and supramolecular structures which are transformed by enzymes into new, active, and supramolecular structures for a variety of potential applications.}, archive = {J_ANGEW}, author = {Subhendu Karmakar and Samuel J. Dettmer and Catherine A. J. Hooper and Nikolas J. Hodges and Michael J. Hannon}, doi = {10.1002/anie.202503683}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503683}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switching on supramolecular DNA junction binding using a human enzyme}, volume = {64}, year = {2025}, }
• (2025). Machine learning-accelerated design of high-efficient lithium adsorbents for salt lake brines. ANGEW, 64(21), e202503644. (www)

  @article{ , abstract = {The urgent demand for lithium resources has been advancing the development of highly efficient lithium extraction from brines. Aluminum-based lithium adsorbent, as the only one used in the Salt Lake industry, is limited in further improving the extraction efficiency due to the low adsorption capacity. Here, we develop a high-throughput screening framework via interpretable machine learning (ML) to rapidly determine high-performance modification strategies for the aluminum-based lithium adsorbent, avoiding the huge workload of traditional trial-and-error doping experiments in view of multiple doping schemes and the unique trade-off between performance and structural stability. Relying on the recommended modifications, a series of doped adsorbents are prepared and the structure stability and cyclic adsorption performance are verified, which match well with the uncovered correlation between dopant features and adsorption capacity. Experimental validations confirm the screened doped one exhibits an increased stable adsorption capacity by nearly 40% in various types of brine. These results indicate that ML-accelerated approach can significantly promote the upgrading of lithium resource adsorption industry in Salt Lakes.}, archive = {J_ANGEW}, author = {Rui Zhang and Siying Liu and Cheng Lian and Jianguo Yu and Sen Lin}, doi = {10.1002/anie.202503644}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning-accelerated design of high-efficient lithium adsorbents for salt lake brines}, volume = {64}, year = {2025}, }
• (2025). Aza-diphosphazenanes: Inorganic cyclohexane-like connectors with stereochemically tunable exit vectors for molecular and macromolecular chemistry. ANGEW, 64(21), e202503568. (www)

  @article{ , abstract = {Molecules that place functional groups at well-defined angular and radial separations are valued as connectors in synthetic chemistry. Examples include rigid, polyvalent arenes and bicyclic compounds featuring strong C─C or C─H bonds. Aliphatic rings are rare in this context due to the challenge of stereochemical control over C─H functionalization. Here we investigate inorganic cyclohexane-like P 2 N 4 rings (aza-diphosphinanes) and develop a model based on negative hyperconjugation and diaxial strain to explain their cis / trans isomerization. Informed by this model, we rationally make 1,4-disubstituted aza-diphosphinanes, and stereoselectively oxidize them to aza-diphosphazenanes, which retain their cis (77°) or trans (180°) covalent exit vectors. These compounds show high stability but nevertheless react as 1,4-dinucleophiles, supporting their classification as new cyclohexane-like connectors. Appropriate connector choice in polycondensations enables the divergent synthesis of low-molecular weight macrocyclic oligomers (from the cis variant) or the first example of high molecular weight cyclo-linear polyphosphazenes (from the trans variant). These results provide fundamental insight into the stereochemistry of inorganic heterocycles and molecular dimensionality, debut connectors that fill a niche left by organic ones, and offer access to new classes of inorganic polymers for future investigation.}, archive = {J_ANGEW}, author = {Michael A. Land and Joseph Bedard and Tanner George and Jason D. Masuda and S. S. Chitnis}, doi = {10.1002/anie.202503568}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503568}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aza-diphosphazenanes: Inorganic cyclohexane-like connectors with stereochemically tunable exit vectors for molecular and macromolecular chemistry}, volume = {64}, year = {2025}, }
• (2025). Asymmetrical triatomic sites with long-range electron coupling for ultra-durable and extreme-low-temperature Zinc–Air batteries. ANGEW, 64(21), e202503493. (www)

  @article{ , abstract = {Reversible zinc–air battery (ZAB) is a promising alternative for sustainable fuel cells, but the performance is impeded by the sluggish oxygen redox kinetics owing to the suboptimal adsorption and desorption of oxygen intermediates. Here, hetero-trimetallic atom catalysts (TACs) uniquely incorporate an electron regulatory role beyond primary and secondary active sites found in dual-atom catalysts. In situ X-ray absorption fine structure (XAFS) and Raman spectroscopy elucidate Fe in FeCoNi SA catalyst (FCN-TM/NC) functions as the main active site, leveraging long-range electron coupling from neighboring Co and Ni to boost catalytic efficiency. The ZAB equipped with FCN-TM/NC exhibits ultra-stable rechargeability (over 5500 h at 1  mA cm −2 under −60 °C). The in-depth theoretical and experimental investigations attribute such superior catalytic activity to the asymmetric FeN 4 configuration, long-distance electron coupling, modulated local microenvironment, optimized d orbital energy levels, and lower energy barrier for bifunctional oxygen electrocatalysis. This work provides a comprehensive mechanistic understanding of the structure-reactivity relationship in TACs for energy conversion.}, archive = {J_ANGEW}, author = {Wencai Liu and Zhanhao Liang and Shaojie Jing and Junjie Zhong and Ning Liu and Bin Liao and Zichen Song and Yihui Huang and Bo Yan and Liyong Gan and Xi Xie and Yichao Zou and Xuchun Gui and Hong Bin Yang and Dingshan Yu and Zhiping Zeng and Guowei Yang}, doi = {10.1002/anie.202503493}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetrical triatomic sites with long-range electron coupling for ultra-durable and extreme-low-temperature Zinc–Air batteries}, volume = {64}, year = {2025}, }
• (2025). Low-symmetry face-capped Fe(II) tetrahedra through anisotropic ligand extension. ANGEW, 64(21), e202503473. (www)

  @article{ , abstract = {Low-symmetry cages are attractive metallo-supramolecular targets, as they may possess different characteristics to their higher symmetry analogs. There are no current generalizable routes for the formation of low-symmetry face-capped tetrahedra. We report here a strategy using tritopic tris -bidentate ligands with arms of different lengths to access novel tetrahedra. The use of “isosceles” ligands (two arms the same, one different) gives tetragonal disphenoid structures, while a “scalene” ligand (all three arms different) gives a rhombic disphenoid structure. In this last case, diastereoselectivity is also achieved. Distortion away from a perfect tetrahedron resulted in alteration of the character of the respective cage. More distorted cages were more prone to loss of structural integrity upon introduction of highly coordinating dimethyl sulfoxide solvent into the cage in acetonitrile solution. As well, increasing distortion was shown to increase the ease of oxidation from Fe(II) to Fe(III) within the cages.}, archive = {J_ANGEW}, author = {Jacob A. Gome and Zack T. Avery and Nina R. Lawson and Oliver G. Stansfield and Jack D. Evans and Michael G. Gardiner and Timothy U. Connell and Dan Preston}, doi = {10.1002/anie.202503473}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503473}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-symmetry face-capped Fe(II) tetrahedra through anisotropic ligand extension}, volume = {64}, year = {2025}, }
• (2025). Hydrogen bond network assisted ultrafast ion transport of anion exchange membrane grafting with covalent organic frameworks for hydrogen conversion. ANGEW, 64(21), e202503372. (www)

  @article{ , abstract = {The development of anion exchange membranes (AEMs) capable of facilitating rapid hydroxide ion transport, while maintaining robust mechanical stability, is considered a key direction for advancing hydrogen energy conversion systems. Herein, we synthesized a series of AEMs by grafting covalent organic frameworks (COFs) onto triphenylpiperidine copolymer and systematically evaluated the performance of AEMs. The tailored COFs, characterized by an extensive hydrogen bond network and high micro-porosity, created interconnected high-speed ion transport channels, significantly reducing the resistance to hydroxide ion conduction. Remarkably, the COF-grafted membranes exhibited superior ionic conductivity compared to pristine triphenylpiperidine, even at lower ion exchange capacities. Additionally, the crystalline and highly rigid structure of the grafted COFs effectively preserved the mechanical stability of the membranes. The optimized COF-grafted AEMs demonstrated outstanding performance, achieving a peak power density of 1.54 W cm −2 in H 2 –O 2 fuel cells and exceptional current densities of 4.5 A cm −2 at 2.0 V in 1 m KOH and 1.1 A cm −2 at 2.0 V in pure water at 80 °C. The present work provides an effective strategy for enhancing AEM performance through the grafting of COFs.}, archive = {J_ANGEW}, author = {Xiaoli Lu and Yi Zhang and Xiaoqin Ma and Caili Yuan and Yuhang Chen and Jingying Guo and Donghui Gao and Yunchuan Tu and Qingfei Liu and Jianchuan Wang and Zidong Wei}, doi = {10.1002/anie.202503372}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503372}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen bond network assisted ultrafast ion transport of anion exchange membrane grafting with covalent organic frameworks for hydrogen conversion}, volume = {64}, year = {2025}, }
• (2025). La3ZrGa5O14: Band-inversion strategy in topology-protected octahedron for large nonlinear response and wide bandgap. ANGEW, 64(21), e202503341. (www)

  @article{ , abstract = {The contradictory relationship between band gaps and the second-harmonic generation (SHG) response constitutes a formidable challenge in the rational design of infrared nonlinear optical (IR NLO) crystals. In oxide-based crystals, the incorporation of strongly distorted octahedra containing d° cations as central elements are a common approach to enhance SHG responses, while inadvertently leading to a significant decrease in band gaps due to the unfavorable energy level splitting. In this study, an innovative “4 d /5 s electron band-inversion” strategy is introduced to enhance SHG response while preserving a wide band gap within the octahedron-symmetry-protected langasite structure. A novel high-performance IR NLO crystal, La 3 ZrGa 5 O 14 (LGZr) is successfully synthesized, where the unoccupied 4 d orbitals of the Zr 4+ cation underwent a transition from the valence band to the bottom of the conduction band, and the ZrO 6 octahedra exhibited minimal distortion. Consequently, LGZr exhibited the largest SHG response observed to date (reaching up to 2.4 × La 3 Nb 0.5 Ga 5.5 O 14 ) and the broadest band gap (5.16 eV) within the langasite family. Furthermore, LGZr is revealed with a remarkable laser damage threshold (1.66 GW/∼cm 2 ) and broad IR transmission capabilities (∼7.8 µm) and supported the growth of centimeter-sized single crystal. The “band-inversion strategy” offers significant advantages to realize high-performance IR NLO crystals.}, archive = {J_ANGEW}, author = {Dazhi Lu and Yuzhou Wang and Xiaoheng Li and Fei Liang and Kui Wu and Haohai Yu and Huaijin Zhang}, doi = {10.1002/anie.202503341}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503341}, shortjournal = {Angew. Chem. Int. Edit.}, title = {La3ZrGa5O14: Band-inversion strategy in topology-protected octahedron for large nonlinear response and wide bandgap}, volume = {64}, year = {2025}, }
• (2025). Reactions of R3PNNPR3 species with boranes: Classical adducts, FLPs, and radical cations. ANGEW, 64(21), e202503331. (www)

  @article{ , abstract = {Although the nature of bis -phosphazine species is of much interest, there are few reports of their reactivity. Herein, we show that the bis -phosphazine species Ph 3 PNNPPh 3 1 react with Lewis acids to give the Lewis acid adducts Ph 3 PNN(B(C 6 F 5 ) 3 )PPh 3 3 and Ph 3 PN(BF 3 )N(BF 3 )PPh 3 4 . Compound 1 also generates a frustrated Lewis pair (FLP) in the presence of BPh 3 and thermolysis of 1 /BPh 3 , or 3 at 80 °C released N 2 while 4 was stable at 80 °C. In contrast, the species Cy 3 PNNPCy 3 2 reacted with B(C 6 F 5 ) 3 to effect single electron transfer affording a frustrated radical pair (FRP). Independent reactions of 1 and 2 with [Cp 2 Fe][BF 4 ] gave the corresponding radical salts [R 3 PNNPR 3 ] •+ [BF 4 ] (R = Cy 5b Ph 6 ). Structural and computational data show the N─N bond is strengthened in the bis -phosphazine radical cation.}, archive = {J_ANGEW}, author = {Vaibhav Bedi and Andrew Niles L. Ocampochua and Zheng-Wang Qu and Stefan Grimme and Douglas W. Stephan}, doi = {10.1002/anie.202503331}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503331}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reactions of R3PNNPR3 species with boranes: Classical adducts, FLPs, and radical cations}, volume = {64}, year = {2025}, }
• (2025). Iridium-free high-entropy alloy for acidic water oxidation at high current densities. ANGEW, 64(21), e202503330. (www)

  @article{ , abstract = {Designing active and cost-effective catalysts for acidic oxygen evolution reaction (OER) is critically important for improving proton exchange membrane water electrolyzers (PEMWEs) used in hydrogen production. In this study, we introduce a rapid and straightforward method to synthesize a quinary high-entropy ruthenium-based alloy (RuMnFeMoCo) for acidic OER. This iridium-free catalyst demonstrates a low overpotential of 170 mV and exceptional stability, enduring a 1000-hour durability test at 10 mA cm −2 in 0.5 M H 2 SO 4 . Microstructural analyses and density functional theory (DFT) calculations reveal that the incorporation of corrosion-resistant elements such as Ru, Mo, and Co enhances the overall stability of the catalyst under acidic conditions. Concurrently, the presence of Mn, Fe, and Co significantly reduces the energy barrier of the rate-determining step in the OER process, thus accelerating the OER kinetics and lowering the overpotential. The PEMWE employing the RuMnFeMoCo catalyst operates stably at high current densities of 500 and 1000 mA cm −2 for over 300 hours with negligible performance degradation. This work illustrates a strategy for designing high-performance OER electrocatalysts by synergistically integrating the benefits of multiple elements, potentially overcoming the activity-stability trade-off typically encountered in the catalyst development.}, archive = {J_ANGEW}, author = {Jinghao Chen and Jiale Ma and Tao Huang and Qichen Liu and Xiaokang Liu and Ruihao Luo and Jingwen Xu and Xiaoyang Wang and Taoli Jiang and Hongxu Liu and Zhenshan Lv and Tao Yao and Gongming Wang and Xusheng Zheng and Zhenyu Li and Wei Chen}, doi = {10.1002/anie.202503330}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503330}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iridium-free high-entropy alloy for acidic water oxidation at high current densities}, volume = {64}, year = {2025}, }
• (2025). Organic room-temperature near-IR phosphorescence harvested by intramolecular through-space sensitization in composite molecules. ANGEW, 64(21), e202503327. (www)

  @article{ , abstract = {A family of coordination compounds with short intramolecular spatial separation between an organic chromophore and a metal center was studied. The specific geometry was realized by means of anthracene-functionalized tertiary aryl phosphanes. Their silver and gold complexes ( 1 , 2 ) operate as conventional fluorophores, with photophysical behavior defined by anthracene-localized allowed transitions. In contrast, bichromophoric species, containing phenyl bipyridine- ( 3 , 5 , 6 , 8 ) or terpyridine- ( 4 , 7 ) derived platinum(II) fragments, demonstrate fast intersystem crossing to the triplet state associated with the pincer metal component. Theoretical results corroborated that the short intramolecular distance between the platinum constituent and the adjacent anthracene facilitates subsequent through-space triplet ( T 2 , pincer fragment)→triplet ( T 1 , anthracene) energy transfer. This process occurs at a rate of ∼10 11 s −1 , surpassing the rates of T 2 →S 0 relaxation. This prevents visible phosphorescence from the platinum(II) motifs but enables near-IR organic phosphorescence in the solid state, including dyes with very inefficient intersystem-crossing (ISC). Thus, the composite molecules 3 – 8 illustrate a feasible approach to the tunable sensitization of organic dyes and the design of low-energy triplet emitters.}, archive = {J_ANGEW}, author = {Iida Partanen and Chao-Hsien Hsu and Emily Hsue-Chi Shi and Iván Maisuls and Toni Eskelinen and Antti J. Karttunen and Jarkko J. Saarinen and Cristian A. Strassert and Andrey Belyaev and Pi-Tai Chou and Igor O. Koshevoy}, doi = {10.1002/anie.202503327}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic room-temperature near-IR phosphorescence harvested by intramolecular through-space sensitization in composite molecules}, volume = {64}, year = {2025}, }
• (2025). Size-programmable matteson-type annulation: Construction of spirocycles from simple cyclic ketones. ANGEW, 64(21), e202503269. (www)

  @article{ , abstract = {Despite the recent advancement, Matteson-type reactions are almost exclusively used to construct linear molecules. Herein we report an iterative boron-homologation approach to construct various carbocycles from a single precursor. This method utilizes an electron-withdrawing group (EWG) as a handle to enable intramolecular Matteson-type couplings, leading to diastereoselective and enantioselective ring formation. An intriguing role of the Lewis acid additive is identified. This approach proves to be general for preparing carbocycles with different ring sizes and multiple stereocenters. The annulation processes are also scalable, and the products can undergo various transformations to provide synthetically valuable structural motifs. In addition, this method can be extended to the preparation of diverse hard-to-make spirocyclic compounds from simple cyclic ketones. Moreover, an iterative approach to synthesize double spirocycles is also demonstrated.}, archive = {J_ANGEW}, author = {Woohyun Jo and Juliane K. Scholz and Hairong Lyu and Seung Hwan Cho and Guangbin Dong}, doi = {10.1002/anie.202503269}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Size-programmable matteson-type annulation: Construction of spirocycles from simple cyclic ketones}, volume = {64}, year = {2025}, }
• (2025). Ion-pair hydrogen atom transfer catalysis enables cr-catalyzed allylation of ketones using hydrocarbon alkenes. ANGEW, 64(21), e202503249. (www)

  @article{ , abstract = {We report a catalytic allylation of ketones using simple hydrocarbon alkenes, enabled by a synergistic system comprising chromocene and photo-activatable ion-pair hydrogen atom transfer (IP-HAT) catalysts derived from a thiophosphoryl imide and N -heteroaromatics. This catalyst system generates highly nucleophilic, electron-rich allylchromium(III) species directly from unactivated alkenes, demonstrating broad applicability to various ketones, including aromatic, aliphatic, and multifunctional ketones. The reaction proceeds under mild conditions with high functional group tolerance. The modular design of the IP-HAT catalysts allows precise tuning of redox potential and HAT activity, with the enhanced reduction potential of the reduced N -heteroaromatics catalyst playing a pivotal role in efficiently regenerating the electron-rich chromocene(II) catalyst.}, archive = {J_ANGEW}, author = {Suguru Arii and Zonghan Yu and Hongyu Chen and Harunobu Mitsunuma and Motomu Kanai}, doi = {10.1002/anie.202503249}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503249}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ion-pair hydrogen atom transfer catalysis enables cr-catalyzed allylation of ketones using hydrocarbon alkenes}, volume = {64}, year = {2025}, }
• (2025). Helicene-fused propellanes: A geometrically rigid multihelicene nanocarbon with amplified chirality. ANGEW, 64(21), e202503225. (www)

  @article{ , abstract = {Here we report the synthesis of a geometrically distinct three-dimensional (3D) chiral nanocarbon, which is composed of three π-extended [6]helicene subunits fused on a [3,3,3]propellane with P,P,M / M,M,P configurations in the helicene subunits. This nanocarbon can isomerize into the thermodynamically more stable isomer with PPP / MMM configurations in the helicene subunits. Both 3D nanocarbons display a very stable configuration, which can be separated by chiral high-performance liquid chromatography (HPLC). Notably, the nanocarbons display significantly enhanced chiroptical properties compared to the reference π-extended [6]helicene, due to the improved alignment of magnetic and electric transition dipole moments. The twisted [6]helicene subunits in the nanocarbon provide concave surfaces that are suitable—albeit relatively weak—hosts for C 60 , forming a 1:2 host-guest complex in the solid-state.}, archive = {J_ANGEW}, author = {Jiahao Ma and Xinyue Liu and Fangfang Hao and Lei Zhang}, doi = {10.1002/anie.202503225}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503225}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Helicene-fused propellanes: A geometrically rigid multihelicene nanocarbon with amplified chirality}, volume = {64}, year = {2025}, }
• (2025). PH-dependent switching between nonlinear-optical-active nitrate-based supramolecular polymorphs. ANGEW, 64(21), e202503136. (www)

  @article{ , abstract = {Tailored syntheses of non-centrosymmetric (NCS) second-order nonlinear optical (NLO) crystals, particularly those of metastable NCS polymorphs, remain extremely challenging due to the complex interactions of their constituent primitives. In this work, we report the first successful synthesis of a set of three nitrate supramolecular polymorphs (C 2 H 5 N 4 )(NO 3 ) (α-, β-, and γ-phases) by a pH-modulation secondary-bond strategy, via the assembly of two types of π-conjugated planar primitives. Solutions of different pH result in differing orientation of secondary bonds between [C 2 H 5 N 4 ] and [NO 3 ] primitives. Secondary bonds dominate the packing of primitives in crystal lattices; varying these secondary bonds can afford NCS or centrosymmetric nitrate supramolecular polymorphs, with 2D α-phase irreversibly transformed to 2D β-phase in a solution of appropriate pH. These two polymorphs display distinctly different SHG responses and birefringences, ascribed to variation in stacking of 2D hydrogen-bond layers resulting from the differing environmental pH. Supramolecular crystal structures comparison and theoretical studies confirm the crucial role played by secondary-bond interactions between adjacent primitives in the rare nitrate supramolecular polymorphs. This work paves the way in elucidating the supramolecular polymorph transition-mechanisms and correlating the polymorph structures and their NLO properties, and thereby discloses a new paradigm for development of high-performance NCS materials with tailored optical properties.}, archive = {J_ANGEW}, author = {Qiao Xia and Xingxing Jiang and Chunbo Jiang and Haijun Zhang and Yilei Hu and Lu Qi and Chao Wu and Guangfeng Wei and Zheshuai Lin and Zhipeng Huang and Mark G. Humphrey and Chi Zhang}, doi = {10.1002/anie.202503136}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503136}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PH-dependent switching between nonlinear-optical-active nitrate-based supramolecular polymorphs}, volume = {64}, year = {2025}, }
• (2025). The cooperative effects of the rh-M dual-metal atomic pairs in formic acid oxidation. ANGEW, 64(21), e202503095. (www)

  @article{ , abstract = {The continuously increasing mass activity of precious metal in formic acid oxidation reaction (FAOR) is the key to achieving the practical application of direct formic acid fuel cells (DFAFCs). Herein, Rh-based dual-metal atomic pairs supported on nitrogen-doped carbon catalysts [DAP-(M, Rh)/CN] with adjacent interatomic Rh-M (M = V, Cr, Mn, Fe, Co, Ni, Cu) have been synthesized by a “host-guest” strategy. It is discovered that DAP-(Cr, Rh)/CN shows the highest mass activity of 64.1 A mg −1 , which is 3.8 times higher than that of the single atom Rh catalyst (17.0 A mg −1 ) and two orders of magnitude higher than Pd/C (0.58 A mg −1 ). Interestingly, the mass activity of DAP-(M, Rh)/CN first increases from 11.7 A mg −1 (Rh-V) to 64.1 A mg −1 (Rh-Cr) and then decreases to 21.8 A mg −1 (Rh-Cu), forming a volcano curve of the reaction activity. Density functional theory calculations combined with in situ Fourier transform infrared spectrometer (FTIR) spectra reveal that formic acid oxidized on a series of DAP-(M, Rh)/CN catalysts through the formate route with the subsidiary M metal atoms binding the HCOO species and the Rh atom accepting the H atoms. The most suitable adsorption strength of HCOO on the Cr sites luckily contributes to two spontaneous elementary steps and thus accelerates the FAOR rates.}, archive = {J_ANGEW}, author = {Runze Ma and Jin Zhang and Jiaxin Gong and Yunxiang Lin and Jialin Zhang and Zheng-Qing Huang and Chun-Ran Chang and Shoujie Liu and Wei Zhu and Yuxin Wang and Ke Zeng and Yu Tao and Jinhua Hu and Zedong Zhang and Xiao Liang and Yunhu Han and Junjie Mao and Zechao Zhuang and Jun Yan and Dingsheng Wang and Yu Xiong}, doi = {10.1002/anie.202503095}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The cooperative effects of the rh-M dual-metal atomic pairs in formic acid oxidation}, volume = {64}, year = {2025}, }
• (2025). Donor-Π-acceptor self-adaptive conjugated perylene derivative with low solubility, high capacity, and swift ion transport kinetics for high performance organic cathode. ANGEW, 64(21), e202503067. (www)

  @article{ , abstract = {Organic perylene has been heralded as a promising candidate due to abundant structural diversity and tunability. However, its practical application is severely plagued by facile solubility, scarce redox-active sites, and andante kinetics behaviors. Herein, the perylene derivative (DPL), i.e., (1,6,7,12-tetrakis (4- tert -butylphenoxy) perylene-3,4,9,10-tetracarboxylic dianhydride) conjugates with polyoxime ester (PO) and is further nested with N, P grafted hollow matrix with anchored Cu single atoms (Cu-NPC). Such Cu-NPC@DPL@PO with helically twisted donor-π-acceptor (D-π-A) conjugate bridged by Cu atoms was evaluated for K + storage. Based on extended π–π conjugated structure, intensified interactions between PO and DPL, the minimal solubility of DPL is approached. Together with the core-shell solvation structure and compact cathode electrolyte interface (CEI) synergistically improves its long lifespan. The abundant stabled radical nitroxides, isocyano groups, and sp-C sites contribute greatly to the capacity elevation. The twisted D-π-A self-adaptive coordination conjugate (TSCC) significantly elevates the distortion toward for the easier tendency to flipping and vibrating and thus expedited kinetics behaviors. Consequently, Cu-NPC@DPL@PO reconciles the trade-off between fast-charging and long cycle stability involved 8-electron participation. This work exemplifies the importance of advanced design of the molecular scale engineering, including modulated redox-active sites and high stability toward for fast-charging and long-lifespan cell devices.}, archive = {J_ANGEW}, author = {Qingxiang Wang and Qinghua Gong and Fusheng Liu and Jian Wang and Yue Li and Guohui Qin and Feixiang Wu}, doi = {10.1002/anie.202503067}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503067}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Donor-Π-acceptor self-adaptive conjugated perylene derivative with low solubility, high capacity, and swift ion transport kinetics for high performance organic cathode}, volume = {64}, year = {2025}, }
• (2025). Electric-dipole coupling ion-dipole engineering induced rational solvation-desolvation behavior for constructing stable solid-state lithium metal batteries. ANGEW, 64(21), e202503037. (www)

  @article{ , abstract = {Solid-state polymer electrolytes (SPEs) with high ionic conductivity, a wide voltage window, and an ultrastability electrolyte/electrode interface are essential for practical applications of solid lithium-metal batteries but particularly challenging. The key to overcoming these long-term obstacles lies in the rational design of the Li + solvation-desolvation behavior in SPEs. Herein, we propose an electric-dipole coupling ion-dipole strategy to modulate the Li + solvation structure and enhance Li + desolvation kinetics. The experimental characterizations and theoretical calculations indicate that the free solvents and FSI − are anchored by ion–dipole interactions, which facilitate the transfer of Li + and obtain a wide electrochemical stability window. Coupling the electric-dipole interactions that promote lithium salt dissociation and rapid ion desolvation contributes to obtaining more mobile Li + and realizing an inorganic-rich electrolyte/electrode interface. Benefiting from the above benefits, the assembled lithium symmetric cells and the full cells demonstrate ultralong cycling life. More importantly, full cells with high-loading cathodes (LiFePO 4 with 11.25 mg cm −2 , NCM811 with 7.84 mg cm −2 ) and pouch cell still display stable cycling. This research gives valuable insights into regulating the solvation-desolvation behavior in SPEs and facilitates the development of state-of-the-art Li metal batteries.}, archive = {J_ANGEW}, author = {Feng Tao and Kaijian Yan and Chenxu Dong and Jiajing Wang and Qianmu Pan and Minjian Gong and Jiapei Gu and Chunli Shen and Ruohan Yu and Yuanzhi Jiang and Mingjian Yuan and Cheng Zhou and Meng Huang and Xu Xu and Liqiang Mai}, doi = {10.1002/anie.202503037}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202503037}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electric-dipole coupling ion-dipole engineering induced rational solvation-desolvation behavior for constructing stable solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Efficient photosynthesis of hydrogen peroxide from water and air over water-dispersible anthraquinone-based porous aromatic frameworks. ANGEW, 64(21), e202502943. (www)

  @article{ , abstract = {Photosynthesis of hydrogen peroxide from earth-abundant water and air over organo-based semiconducting materials is a promising alternative to the traditional anthraquinone (AQ) method. However, the generally hydrophobic nature of organic semiconductors has led to their poor dispersibilities in aqueous systems, which built huge barriers for photon capture and reactant contact in water-based photocatalysis. Aiming at this issue, this study reports the facile synthesis of AQ-based porous aromatic frameworks (AQ-PAFs) by coupling AQ fragments with thiophene-derived linkers via robust carbon–carbon bonds. Remarkably, the interfacial hydrogen bonding interactions between water molecules and AQ sites on the surface improve the general hydrophilicity of AQ-PAFs, which can be well-dispersed in water-only systems with uniform particle size distributions. Moreover, the AQ moieties also function as mediators of photoinduced electrons, and the protons produced from water oxidation reaction (WOR), which would kinetically favor the charge separation and subsequent electron transfer reactions. The mono-dispersed AQ-PAF photocatalyst promotes hydrogen peroxide (H 2 O 2 ) photosynthesis from water and air under visible light achieving a high productivity of 7124 µmol g −1 h −1 in the absence of any organic alcohol reagents among organic semiconductor photocatalysts. Furthermore, a continuous H 2 O 2 photosynthesis for 190 h is also achieved in a flow system.}, archive = {J_ANGEW}, author = {He Wang and Linzhu Cao and Xin Tao and Guangshan Zhu}, doi = {10.1002/anie.202502943}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502943}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient photosynthesis of hydrogen peroxide from water and air over water-dispersible anthraquinone-based porous aromatic frameworks}, volume = {64}, year = {2025}, }
• (2025). Suppressing spontaneous acidic corrosion and hydrogen evolution for stable Zn//MnO2 batteries. ANGEW, 64(21), e202502896. (www)

  @article{ , abstract = {Rechargeable aqueous Zn//MnO 2 batteries have attracted significant attention due to their high safety and cost-effective for potential large-scale energy storage. However, the severe acidic corrosion and hydrogen evolution reaction (HER) on Zn anodes in acidic electrolytes pose critical challenges to their practical application. Here, we introduce trace amounts of p -hydroxybenzaldehyde (M4) into the electrolyte to address the above anode issues. Leveraging its strong affinity for Zn 2+ and H 2 O, M4 molecules reconstruct the Zn(H 2 O) 6 2+ solvation sheath and adsorb onto the anode surface, effectively blocking direct contact between H + and Zn. This dual action significantly mitigates acidic corrosion and HER, enhancing Zn anode reversibility and stability. Benefiting from these merits, symmetric cells exhibit exceptional cycling stability of over 2000 h at 5 mA cm −2 and 1 mAh cm −2 , delivering a fivefold increase in lifespan compared to conventional electrolytic cells. Moreover, Zn//MnO 2 batteries demonstrate stable operation for more than 3000 cycles in acidic electrolyte with an average Coulombic efficiency (CE) exceeding 97.3%. The assembled pouch cell delivers a high capacity of 1.68 Ah, maintaining stable operation for over 100 cycles. This work presents unique perspectives and offers promising avenues to improve the stability and efficiency of aqueous battery systems.}, archive = {J_ANGEW}, author = {Yinna Liu and Zhexuan Liu and Zhiqiang Xiao and Zhoujie Lao and Jiachang Liu and Xiao Xiao and Qingjin Fu and Fengyi Zheng and Guangmin Zhou}, doi = {10.1002/anie.202502896}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502896}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Suppressing spontaneous acidic corrosion and hydrogen evolution for stable Zn//MnO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Capturing unstable carbanionic intermediates via halogen transfer: Base-promoted oxidative coupling reactions of α,α-difluoromethylarenes. ANGEW, 64(21), e202502894. (www)

  @article{ , abstract = {We describe how the merger of deprotonation, halogenation, and substitution into compatible processes enables the productive functionalization of traditionally unstable carbanionic intermediates. This strategy enables the first oxidative coupling protocol of α,α-difluorobenzylic C─H bonds with heteronucleophiles. Here, transiently generated α,α-difluorobenzylic carbanionic intermediates undergo halogen transfer from 2-bromothiophenes to form electrophilic ArCF 2 Br compounds for in situ nucleophilic substitution, thereby avoiding α-fluoride elimination pathways that typically plague α-fluorocarbanions. This method streamlines the modular synthesis of α,α-difluorobenzyl(thio)ethers and led to the broader realization that halogen transfer to unstable carbanions is an enabling principle across diverse C(sp 2 )─H and C(sp 3 )─H systems.}, archive = {J_ANGEW}, author = {Leidy V. Hooker and Jeffrey S. Bandar}, doi = {10.1002/anie.202502894}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502894}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Capturing unstable carbanionic intermediates via halogen transfer: Base-promoted oxidative coupling reactions of α,α-difluoromethylarenes}, volume = {64}, year = {2025}, }
• (2025). A phenazine-based two-dimensional covalent organic framework for photochemical CO2 reduction with increased selectivity for two-carbon products. ANGEW, 64(21), e202502799. (www)

  @article{ , abstract = {The reduction of carbon dioxide (CO₂) into valuable products will contribute to sustainable carbon use. Here we report the photocatalytic reduction of CO₂ to carbon monoxide, formate, and oxalate ions using a redox-active phenazine-based 2D covalent organic framework ( Phen-COF ) and its phenazine monomer. Under similar irradiation conditions, Phen-COF produced 2.9 times more CO, 11 times more formate, and 13 times more oxalate compared to equimolar amounts of the monomeric phenazine, demonstrating that the COF architecture enhances catalytic performance (TOF COF : 10 −7 s −1 CO, 10 −8 s −1 formate, and 10 −11 s −1 oxalate). Structural analysis, including X-ray diffraction and N₂ porosimetry, confirmed the COF's long-range order and porosity. Mechanistic studies suggest a sequential formate-to-oxalate pathway, with CO and formate acting as intermediates. These results demonstrate the potential of the COF architecture to improve the performance of metal-free, redox-active aromatic systems such as phenazines to facilitate efficient and selective CO₂ conversion under mild conditions.}, archive = {J_ANGEW}, author = {Zoheb Hirani and Neil M. Schweitzer and Edon Vitaku and William R. Dichtel}, doi = {10.1002/anie.202502799}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502799}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A phenazine-based two-dimensional covalent organic framework for photochemical CO2 reduction with increased selectivity for two-carbon products}, volume = {64}, year = {2025}, }
• (2025). Monocarboxylic acid structural analogues facilitate in situ composite of functional complexes for aqueous batteries. ANGEW, 64(21), e202502752. (www)

  @article{ , abstract = {In situ composite methods have aroused research interest in materials science and acted as a novel strategy to achieve structural tailoring of materials. However, the controllable preparation of composites containing functional groups remains a challenge. Herein, we report an approach based on competitive coordination between structural analogs, by which the functionally composite metal complex (NiSH@Ni-FSA) was synthesized. The introduction of different functional groups allows precise control of the functionality of composites, ranging from NiSH@Ni-ClSA-D, NiSH@Ni-BrSA to NiSH@Ni-CF 3 SA. More interestingly, the synthesized material retained the microporous and mesoporous structure of the original complexes. The incorporation of hydrophobic functional groups effectively protects the electrode materials from degradation and corrosion. Meanwhile, the presence of intermolecular hydrogen bonding facilitates new composite nanomaterials with better performance for advanced energy storage applications.}, archive = {J_ANGEW}, author = {Yichun Su and Yanfei Zhang and Wanchang Feng and Guangxun Zhang and Yangyang Sun and Chenhui Yin and Guoqiang Yuan and Yijian Tang and Wenfeng Zhou and Hsiao-Chien Chen and Huan Pang}, doi = {10.1002/anie.202502752}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502752}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Monocarboxylic acid structural analogues facilitate in situ composite of functional complexes for aqueous batteries}, volume = {64}, year = {2025}, }
• (2025). High entropy boosts the low temperature na+-storage performance of Na4Fe3(PO4)2P2O7. ANGEW, 64(21), e202502693. (www)

  @article{ , abstract = {Na 4 Fe 3 (PO 4 ) 2 P 2 O 7 (NFPP) is considered a promising cathode material for sodium ion batteries (SIBs). However, the inferior electronic conductivity and inadequate Na + ions diffusion kinetics of NFPP at low temperatures hinder its practical applications. In this study, high entropy Na 4 Fe 2.95 (MgCaAlCrMn) 0.01 (PO 4 ) 2 P 2 O 7 (HE-NFPP) has been synthesized via a spray-drying and high temperature sintering technique. The incorporation of transition metal (TMs) ions into NFPP through HE strategy facilitates electron transportation by reducing the bandgap between the conduction and valence bands. Meanwhile, the 3D network Na + ions diffusion channels formed in HE-NFPP can effectively improve the Na + ions diffusion efficiency, resulting in enhanced electrode reaction kinetics at low temperatures. Moreover, it leads to a significantly mitigated volume expansion/contraction in HE-NFPP caused by Na + ions extraction/insertion during (de)sodiation process. Consequently, the fabricated HE-NFPP exhibits an excellent rate and cyclic performance at low temperatures.}, archive = {J_ANGEW}, author = {Pengyuan Dong and Fan Peng and Qimeng Zhang and Hao Wang and Youqi Chu and Changdong Chen and Chenghao Yang}, doi = {10.1002/anie.202502693}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502693}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High entropy boosts the low temperature na+-storage performance of Na4Fe3(PO4)2P2O7}, volume = {64}, year = {2025}, }
• (2025). Energy efficiency limit in CO-to-ethylene electroreduction and the method to advance toward. ANGEW, 64(21), e202502690. (www)

  @article{ , abstract = {The electrified synthesis of high-demand feedstocks (C 2 H 4 ) from CO and H 2 O through a CO electroreduction (COR) protocol is attractive for large-scale applications; however, a high reaction potential and modest Faradaic efficiencies (FEs) limit its practical energy efficiency (EE). In this study, a quantitative reaction–transport model was constructed to analyze the root causes of low performance in COR, which revealed low volumetric exchange current density and limited intermediate surface reaction as key factors, constraining CO-to-C 2+ and CO-to-C 2 H 4 conversion energetics and selectivities. Consequently, a robust, high active-site density electrode, featuring nanometer-scale interspacing between the active, Nafion-wrapped Cu + –Cu nanosheet catalysts, was designed. This design increases volumetric COR activity with an efficient intermediate surface reaction mechanism for C 2 H 4 production, substantially lowering the full-cell COR potential to 1.87 V at 4 A in a 25 cm 2 membrane electrode assembly, thereby achieving a record >50% C 2+ EE with a 90 ± 1% FE along with a >40% C 2 H 4 EE with a 71 ± 1% FE throughout stable >100 h operation. Similarly designed high-volumetric-activity Bi and Ag nanosheet catalysts enabled >60% and >55% EEs for the CO 2 -to-formate and CO 2 -to-CO electroreduction, demonstrating the broader applicability of our electrochemical activity and EE enhancement concept on a three-phase interface.}, archive = {J_ANGEW}, author = {Jin Zhang and Haoyang Jiang and Xiaotong Zhao and Zhaoyang Liu and Le Li and Weiping Ding and Miao Zhong}, doi = {10.1002/anie.202502690}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502690}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Energy efficiency limit in CO-to-ethylene electroreduction and the method to advance toward}, volume = {64}, year = {2025}, }
• (2025). Convergent assembly of homo- and heterotypic ubiquitin chains from functionalized, expressed monomers via thiol-ene chemistry. ANGEW, 64(21), e202502638. (www)

  @article{ , abstract = {Nature constructs ubiquitin tags with high spatiotemporal precision to execute defined functions that critically rely on the exact molecular composition of the ubiquitin chain. Deciphering the complex ubiquitin code is of paramount interest in biology and requires flexible access to homogeneous ubiquitin tags. As enzymatic approaches suffer from inherent drawbacks such as hardly controllable chain length or connectivity and substrate-specificity, we apply a combination of expression and chemical tools to assemble ubiquitin chains. Our strategy includes expression of ubiquitin–intein fusion constructs to obtain large quantities of defined ubiquitin monomers with C-terminal modifications such as hydrazides and propargylamides. Linkages between ubiquitins are generated via photoinitiated thiol-ene click (TEC) chemistry, resulting in a nearly native isopeptide bond. We demonstrate the generation of homo- and heterotypic ubiquitin oligomers with K27, 29, 48, and 63 linkages up to a K48-linked tetramer. The presented toolbox allows selective installation of ubiquitin on target peptides and proteins with reactive cysteine residues as demonstrated for segments of the microtubule-associated protein tau. Such segments can be implemented into protein semisyntheses as shown here for ubiquitylated full-length Tau4. The presented work combines minimal synthetic effort with high fidelity linkage chemistry, paving the way toward homogeneously ubiquitylated proteins.}, archive = {J_ANGEW}, author = {Moritz Urschbach and Susanne Huhmann and Dominik Appel and Luca Ferrari and Dominik Vogl and Sascha Martens and Christian F. W. Becker}, doi = {10.1002/anie.202502638}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502638}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Convergent assembly of homo- and heterotypic ubiquitin chains from functionalized, expressed monomers via thiol-ene chemistry}, volume = {64}, year = {2025}, }
• (2025). Versatile C─H alkylation and alkylidenation via catalytic alkylidene transfer of enones. ANGEW, 64(21), e202502619. (www)

  @article{ , abstract = {The alkylidene transfer reactions of alkenes are of particular significance but challenging. Here, we report that enones can serve as diverse alkylidene sources for catalyst-controlled selective C─H alkylation and/or alkylidenation of various nucleophiles. Treatment of a mixture of ketone (or lactam), enone, and diarylmethanol, with a catalytic amount of Y[N(TMS) 2 ] 3 , gave the corresponding α-C─H bond alkylation products derived from the alkylidene transfer from enones to ketones/lactams, whereas the reaction of enones with various C-nucleophiles in the presence of KOH as a catalyst resulted in C─H alkylidenation. Moreover, the application of these strategies for the late-stage modification or structural simplification of some bioactive molecules is also presented. These alkylidene transfer reactions are characterized by operational simplicity, mild reaction conditions, and remarkable catalyst-controlled product outcomes. These results not only demonstrate a significant potential for easily accessible and recyclable enones to serve as versatile alkylidene sources in C─H alkylation and alkylidenation but also provide an attractive and concise method for hydrodealkylidenation of electron-deficient alkenes.}, archive = {J_ANGEW}, author = {Yitu Wang and Xiaoke Shou and Yi Xu and Xigeng Zhou}, doi = {10.1002/anie.202502619}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502619}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Versatile C─H alkylation and alkylidenation via catalytic alkylidene transfer of enones}, volume = {64}, year = {2025}, }
• (2025). Formulating electrophilic electrolyte for in situ stabilization of 4.8 v li-rich batteries with 100% initial coulombic efficiency. ANGEW, 64(21), e202502603. (www)

  @article{ , abstract = {Lithium-rich layered oxide (LLO) cathodes are expected to overcome the energy density limitations, but their applicability is hindered by low initial Coulombic efficiency (ICE) and unstable electrode-electrolyte interphases with sluggish kinetics. Here an elaborate electrophilic electrolyte is proposed that effectively stabilizes the surface lattice oxygen of the LLO cathode, facilitates the formation of dense and fast-ion-transport electrode-electrolyte interphases, and prevents Li-dendrites on the anode. The nucleophilic reaction mechanism driven by the electrolyte enables LLO to exhibit a reversible capacity of 310 mAh g −1 with a record ICE of 100%, as well as impressive 3C fast-charging stability, remarkably superior to that in the basic electrolyte. Using this engineered electrolyte, the assembled 4.5 Ah-class pouch cell of graphite||LLO displays high energy density and remarkable reversibility during cycling, demonstrating wide applicability. This work provides valuable insights and pragmatic strategies in electrolyte chemical engineering for advancing high-energy density and fast-charging batteries.}, archive = {J_ANGEW}, author = {Anping Zhang and Zhihong Bi and Endian Yang and Tongle Chen and Xiaofeng Li and Shihao Liao and Gongrui Wang and Yan Yu and Xinhe Bao and Zhong-Shuai Wu}, doi = {10.1002/anie.202502603}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502603}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formulating electrophilic electrolyte for in situ stabilization of 4.8 v li-rich batteries with 100% initial coulombic efficiency}, volume = {64}, year = {2025}, }
• (2025). Understanding and tuning Singlet–Triplet (S1–T1) energy gaps in planar organic chromophores. ANGEW, 64(21), e202502485. (www)

  @article{ , abstract = {Molecules with large gaps between their first singlet and triplet excited states (Δ E ST ) are key components of various modern technologies, most prominently singlet fission photovoltaics and triplet–triplet annihilation upconversion (TTA-UC). The design of these molecules is hampered by the fact that only limited rules for maximizing Δ E ST exist, other than increasing the overlap between the frontier molecular orbitals (FMO). Here we suggest a new strategy for tuning and maximizing Δ E ST based on a detailed analysis of the underlying quantum mechanical energy terms. We present a model based on the transition density and derive three straightforward design rules: Δ E ST values can be maximized by (i) minimizing the overall number of π-electrons, (ii) reducing delocalization, and (iii) optimizing specific geometric interactions. The validity of these rules is first exemplified for a set of 18 hydrocarbon backbones before proceeding to a varied set of dye molecules, highlighting their transferability to realistic settings. We believe that the developed rules will provide an enormous boost to the field, enabling rational design instead of trial-and-error screening. More generally, this work demonstrates the power of going beyond the FMO approximation in designing advanced molecular materials.}, archive = {J_ANGEW}, author = {Weixuan Zeng and Cheng Zhong and Hugo Bronstein and Felix Plasser}, doi = {10.1002/anie.202502485}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502485}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Understanding and tuning Singlet–Triplet (S1–T1) energy gaps in planar organic chromophores}, volume = {64}, year = {2025}, }
• (2025). Four-centre, multielectron bonding in rare-earth germole sandwich complexes. ANGEW, 64(21), e202502455. (www)

  @article{ , abstract = {Reduction of the germole-ligated sandwich complexes [(η 5 -Cp Ge )M(η 5 -Cp ttt )] 2 ( 1 M , M = Y, Gd, Dy) with one or two equivalents of KC 8 /2.2.2-cryptand produces [{(η 5 -Cp Ge )M(η 5 -Cp ttt )} 2 ] − ( 2 M ) and [{(η 5 -Cp Ge )M(η 5 -Cp ttt )} 2 ] 2− ( 3 M ), respectively, as salts of [K(2.2.2-cryptand)] + (Cp Ge = [GeC 4 -2,5-(SiMe 3 ) 2 –3,4-Me 2 ] 2− , Cp ttt = 1,2,4-C 5 t Bu 3 H 2 . X-ray crystallography shows that the bond lengths within the central {M 2 Ge 2 } rings contract markedly with each reduction. Computational analysis reveals the presence of unusual four-center, multielectron {M 2 Ge 2 } bonds, with the reduction increasing the germanium–germanium and metal–germanium bond orders while reducing the metal-Cp ttt bond order. Analysis of 2 Y by EPR spectroscopy reveals delocalization of the unpaired spin across both yttrium centers. Magnetic measurements on radical-bridged 2 Gd show a large exchange coupling constant of −95 cm −1 (−2 J formalism). Single-molecule magnet behavior is found for the dysprosium–germole complexes. Complexes 1 Y , 2 Y, and 3 Y can be interconverted by one-electron oxidation or reduction reactions of 2 Y , which itself can also be formed by comproportionation of 1 Y and 3 Y . The masked divalent reactivity of 3 Y is demonstrated through one-electron reduction of 2,2′-bipyridyl to give [(η 5 -Cp Ge )Y(η 5 -Cp ttt )(2,2′-bipy)] − ( 4 Y ) and activation of Ph 2 Se 2 to give [(η 5 -Cp Ge )Y(η 5 -Cp ttt )(SePh)] − ( 5 Y ).}, archive = {J_ANGEW}, author = {Siddhartha De and Arpan Mondal and Jem Pitcairn and Lucy Clark and Jinkui Tang and Akseli Mansikkamäki and Richard A. Layfield}, doi = {10.1002/anie.202502455}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502455}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Four-centre, multielectron bonding in rare-earth germole sandwich complexes}, volume = {64}, year = {2025}, }
• (2025). Using color to control conformation in a chemical system containing multiple tricyanofuran photoacids. ANGEW, 64(21), e202502437. (www)

  @article{ , abstract = {Color vision relies on selective, reversible isomerization by visible light of a mixture of retinyl chromophores in photoreceptor cells. Synthetic molecular mimics of this wavelength-dependent induction of function are rare, despite the attractiveness of controlling chemical processes solely by the wavelength of incident light. Here, we report a color-responsive chemical system that is composed of a cationic receptor complex, two competing chiral anionic ligands, and two metastable photoacids with contrasting absorption properties. Tricyanofuran photoacids are synthesized with absorption maxima of varying wavelengths across the whole visible spectrum. Protons released by the photoacids upon selective irradiation reversibly mask the more basic receptor-bound ligand, leading to ligand exchange that can be observed as a shift in the circular dichroism (CD) spectrum of the reporter complex. A ≈90 nm separation between the absorbance maxima of the photoacids allowed each to be selectively photoisomerized in the presence of the other. The concentration of released protons, and hence the magnitude of the shift in CD response, are controlled by changing the wavelength of the incident visible light. Different output behaviors (OR/AND logic gates and wavelength detection) are programmed into the system by varying the relative proportions of the photoacids.}, archive = {J_ANGEW}, author = {Matthew M. Wootten and Sofja Tshepelevitsh and Ivo Leito and Jonathan Clayden}, doi = {10.1002/anie.202502437}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502437}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Using color to control conformation in a chemical system containing multiple tricyanofuran photoacids}, volume = {64}, year = {2025}, }
• (2025). Unlocking the potential of machine learning in co-crystal prediction by a novel approach integrating molecular thermodynamics. ANGEW, 64(21), e202502410. (www)

  @article{ , abstract = {Co-crystal engineering is of interest for many applications in pharmaceutical, chemical, and materials fields, but rational design of co-crystals is still challenging. Although artificial intelligence has revolutionized decision-making processes in material design, limitations in generalization and mechanistic understanding remain. Herein, we sought to improve prediction of co-crystals by combining mechanistic thermodynamic modeling with machine learning. We constructed a brand-new co-crystal database, integrating drug, coformer, and reaction solvent information. By incorporating various thermodynamic models, the predictive performance was significantly enhanced. Benefiting from the complementarity of thermodynamic mechanisms and structural descriptors, the model coupling three thermodynamic models achieved optimal predictive performance in coformer and solvent screening. The model was rigorously validated against benchmark models using challenging independent test sets, showcasing superior performance in both coformer and solvent predicting with accuracy over 90%. Further, we employed SHAP analysis for model interpretation, suggesting that thermodynamic mechanisms are prominent in the model's decision-making. Proof-of-concept studies on ketoconazole validated the model's efficacy in identifying coformers/solvents, demonstrating its potential in practical application. Overall, our work enhanced the understanding of co-crystallization and highlighted the strategy that integrates mechanistic insights with data-driven models to accelerate the rational design and synthesis of co-crystals, as well as various other functional materials.}, archive = {J_ANGEW}, author = {Yutong Song and Yewei Ding and Junyi Su and Jian Li and Yuanhui Ji}, doi = {10.1002/anie.202502410}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502410}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking the potential of machine learning in co-crystal prediction by a novel approach integrating molecular thermodynamics}, volume = {64}, year = {2025}, }
• (2025). Conditional activation of protein therapeutics by templated removal of peptide nucleic acid masking groups. ANGEW, 64(21), e202502268. (www)

  @article{ , abstract = {Interleukin-2 (IL-2)-based therapeutics are emerging as treatments for immunotherapy; however, systemic activation of immune cells hampers their success. Chemically controlling the activity of potent cytokines could mitigate unwanted T cell stimulation and widen their therapeutic window. In this study, we developed a strategy for the conditional activation of proteins utilizing removable peptide nucleic acid (PNA) masking groups. Site-specific installation of “Lock”-PNAs containing a cleavage thioester linkage enabled steric blockage of receptor binding sites. Rapid unmasking and activation were performed by the addition of a complementary “Key”-PNA containing a cysteine (Cys) residue, which forms a PNA–PNA duplex leading to a proximity-accelerated cleavage step and release of the active protein. We exemplified the versatility of this methodology on de novo cytokine neoleukin-2/15 (Neo-2/15) through the preparation of PNA conjugates including homodimers, PNA-stapled conjugates, and dual PNA-bridged dimers. All constructs were effectively unmasked at low micromolar concentrations. Further, we demonstrated the conditional activation of a masked conjugate of Neo-2/15 in binding studies to the IL-2 receptors and in an ex vivo T cell signaling assay displaying a 480-fold potency increase upon activation. Finally, we extended the strategy to a designed ankyrin repeat protein (DARPin) activating the human CD40 receptor demonstrating successful masking and unmasking.}, archive = {J_ANGEW}, author = {Bengt H. Gless and Elisabeth Jones and Carlos Labão-Almeida and Cong Tang and Nicole Gottscheber and Renata Couto and Gonçalo J. L. Bernardes}, doi = {10.1002/anie.202502268}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502268}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conditional activation of protein therapeutics by templated removal of peptide nucleic acid masking groups}, volume = {64}, year = {2025}, }
• (2025). Three birds with one stone: Triple defect passivation of tris(2,2,2-trifluoroethyl) phosphate enables 25.69% efficient inverted perovskite solar cells. ANGEW, 64(21), e202502244. (www)

  @article{ , abstract = {Defect passivation is widely acknowledged as a crucial strategy for enhancing the efficiency and stability of perovskite solar cells (PSCs). However, it remains a formidable challenge to effectively address multiple defects simultaneously on both the top and bottom surfaces of perovskite films, as well as within the bulk, through a facile method. To tackle this dilemma, we have devised a triple passivation strategy, aiming to achieve a holistic passivation of defects at the aforementioned locations using a singular passivator. Specifically, a multifunctional molecule, tris(2,2,2-trifluoroethyl) phosphate (TTFP), is meticulously engineered as an additive in the antisolvent. This approach capitalizes a top-down gradient distribution of TTFP along the perovskite film, thereby enabling to mitigate the interfacial and bulk defects. Meanwhile, the unique molecular structure of TTFP facilitates simultaneous interactions with both cationic and anionic defects. Additionally, TTFP exerts a pronounced influence on the crystallization kinetics, thereby promoting the formation of highly crystalline perovskite films with substantially enlarged grain sizes. Consequently, the TTFP-based devices exhibit a champion power conversion efficiency (PCE) of 25.69%, accompanied by a notable improvement in stability. This work represents the successful implementation of comprehensive defect passivation, marking a significant instance in the advancement of efficient and stable PSCs technology.}, archive = {J_ANGEW}, author = {Guiqi Zhang and Yinhua Lv and Zhenhuang Su and Yumin Ren and Tian Geng and Qianqian Liu and Weilin Ran and Xingyu Gao and Wen-Hua Zhang}, doi = {10.1002/anie.202502244}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502244}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three birds with one stone: Triple defect passivation of tris(2,2,2-trifluoroethyl) phosphate enables 25.69% efficient inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Allenylidene phosphonium ion: An isoelectronic phosphorus analogue of [3]Cumulene. ANGEW, 64(21), e202502201. (www)

  @article{ , abstract = {Herein, we disclose the synthesis, characterization, and bonding analysis of a crystalline allenylidene phosphonium ion ([R 2 P═C═C═CAr 2 ] + ) [ 2 ] + (R = 1,3-diisopropylphenylimidazolin-2-ylidenamino, CAr 2 = 9-fluorenylidene), an isolobal analogue of [3]cumulenes. The cation was prepared via methoxide ion abstraction of an alkynyl phosphine 1 . Electron rich N -heterocyclic imine substituents and a π conjugated fluorenyl scaffold together stabilize the resulting three-coordinate phosphonium center of [ 2 ] + . [ 2 ] + features a trigonal planar phosphorus atom which is electrophilic, as evidenced experimentally by the preparation of a Lewis acid-base adduct with 4-dimethylaminopyridine, and fluoride ion affinity calculations. Crystallographic and computational investigations of [ 2 ] + support a structure with considerable P═C double bond character. Furthermore, this P═C double bond participates in a thermally reversible intramolecular dearomative [2 + 2] cycloaddition with an arene moiety of one of its supporting 1,3-diisopropylphenylimidazolin-2-ylidenamino substituents to give a tetracyclic isomer [ 2 cyclo ] + . The isolation of a free [R 2 P═C═C═CAr 2 ] + draws further parallels between the properties and reactivity of low-coordinate phosphorus compounds and related carbon compounds.}, archive = {J_ANGEW}, author = {Lucas C. Torres and Pawel Löwe and Avik Bhattacharjee and Maike B. Röthel and Michael Seidl and Jesse LeBlanc and Klaus Wurst and Fabian Dielmann and Christopher B. Caputo}, doi = {10.1002/anie.202502201}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502201}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Allenylidene phosphonium ion: An isoelectronic phosphorus analogue of [3]Cumulene}, volume = {64}, year = {2025}, }
• (2025). Stimuli-responsive circularly polarized luminescence of gold clusters based on hydrogen-bond driven intercluster coupling. ANGEW, 64(21), e202502168. (www)

  @article{ , abstract = {Stimuli-responsive circularly polarized luminescence (CPL) metal clusters hold significant potential in high-security encryption and sensing applications, yet the exploration of hydrogen-bond-driven CPL-active metal clusters remains limited. Here, we report the synthesis of an enantiomeric pair of rhomboid Au 4 clusters utilizing chiral R/S -4-hydroxymethyl-5-methyloxazole-2-thione ( R/S -HMMT ) ligands. Two enantiomeric pairs of self-assembled metal clusters R/S -Au 4 (HMMT) 4 -blue and R/S -Au 4 (HMMT) 4 -red were obtained, by constructing distinct intercluster hydrogen bonds through the use of different crystalline solvents. In R/S -Au 4 (HMMT) 4 -blue , 1,4-dioxane guest molecules were observed to form a hydrogen-bond network with the hydroxyl groups of the cluster surface ligands. In contrast, a different hydrogen-bond network involving the hydroxyl groups of the surface ligands was identified in R/S -Au 4 (HMMT) 4 -red , resulting in a distinct stacking pattern. The unique intercluster couplings mediated by hydrogen bonds result in R/S -Au 4 (HMMT) 4 -blue exhibiting a blue CPL emission at 466 nm, while R/S -Au 4 (HMMT) 4 -red shows a dual CPL emission at 446 and 727 nm. Theoretical calculations reveal that hydrogen-bond driven intercluster couplings in R -Au 4 (HMMT) 4 -red are significantly stronger than in R -Au 4 (HMMT) 4 -blue . Additionally, both solid R/S -Au 4 (HMMT) 4 -blue and R/S -Au 4 (HMMT) 4 -red undergo reversible CPL transformations in response to organic vapors, temperature, or mechanical stimuli, due to the destruction and reconstruction of hydrogen-bond networks. These characteristics make them promising materials for information encryption applications.}, archive = {J_ANGEW}, author = {Si-Meng Zhai and Han Zhang and Yan Wang and Li-Xin Zhang and Wen-Yang Jiao and Ya-Qing Zhang and Yubing Si and Hai-Yang Li and Shuang-Quan Zang and Zhen Han}, doi = {10.1002/anie.202502168}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502168}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stimuli-responsive circularly polarized luminescence of gold clusters based on hydrogen-bond driven intercluster coupling}, volume = {64}, year = {2025}, }
• (2025). Chiral gold nanostructure monolayers as SERS substrates for ultrasensitive detection of enantiomer biomarkers of alzheimer's disease. ANGEW, 64(21), e202502115. (www)

  @article{ , abstract = {The early diagnosis of neurodegenerative diseases, such as Alzheimer's disease (AD), requires the identification of sensitive and specific biomarkers. Detecting chiral molecules at concentrations relevant to disease states remains challenging. Herein, a new type of chiral gold nanostructure induced by D-/L-cysteine–leucine dipeptides with a g -factor of 0.1 was successfully synthesized for enantiomer biomarker detection. To enhance the discrimination performance, the chiral gold nanostructures were assembled into D-/L-Au monolayers. As surface-enhanced Raman scattering (SERS) substrates, the D-/L-Au monolayers simultaneously deliver molecular structural specificity and enantioselectivity within a single spectrum, which can be a versatile, label-free chiral discrimination strategy for the detection of D-/L-kynurenine (Kyn). The mechanism was unveiled to involve high enantioselective adsorption energies between L- and D-Kyn on the lattice plane (221), resulting in enantioselective sensing. The results showed that the L-Au monolayer reached a limit of detection (LOD) of 3.7 n m for L-Kyn, while the D-Au monolayer reached an LOD of 3.6 nM for D-Kyn. Notably, there was a significant difference in D-Kyn levels between AD patients and healthy individuals in serum samples, a distinction not observed for L-Kyn, which positioned D-Kyn as a potential novel biomarker for clinical prediagnosis of AD patients, marking the first report of its kind worldwide. This study provides a robust tool for advancing biomedical science and clinical diagnostics.}, archive = {J_ANGEW}, author = {Changlong Hao and Dan Meng and Wenxiong Shi and Chuanlai Xu and Qing Wang and Hua Kuang}, doi = {10.1002/anie.202502115}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502115}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral gold nanostructure monolayers as SERS substrates for ultrasensitive detection of enantiomer biomarkers of alzheimer's disease}, volume = {64}, year = {2025}, }
• (2025). Miniaturized separation-sensing tandem enabled by fluorescent monoliths. ANGEW, 64(21), e202502020. (www)

  @article{ , abstract = {Discriminative sensing for mixture by either fluorescent sensor or other sensors remains a challenge. This issue is attributed to the absence of a separation unit prior to the sensor. Here, we report a new sensing medium, named porous fluorescent monolith, which can separate mixture and meanwhile be integrated into a sensor for discriminative detection. The fluorescent monoliths are prepared via polymerization of 4,4′,4″,4 ‴ -(ethene-1,1,2,2-tetrayl)tetrabenzaldehyde with diamines. Their photophysical property and hierarchical porosity are systematically studied. On this basis, we set up a separation-sensing platform and realize quantitative analysis for trace water in methanol, a sarin simulant, perfluoroalkyl compounds, and metal ions. The separation-sensing platform furthermore demonstrates baseline separation for benzene, toluene, ethylbenzene, and xylene, with limit of detections of 86, 54, 19, and 58 ng, respectively. To our knowledge, this is the first time that a fluorescent monolith is used to realize a separation-sensing tandem. We anticipate our findings will provide a promising strategy for producing portable devices with the on-site discriminative sensing ability for real samples.}, archive = {J_ANGEW}, author = {Jie Wang and Ruijuan Wen and Jinglin Kong and Jing Liu and Zhongshan Liu and Yu Fang}, doi = {10.1002/anie.202502020}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502020}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Miniaturized separation-sensing tandem enabled by fluorescent monoliths}, volume = {64}, year = {2025}, }
• (2025). SiO2 nanoparticles-induced antifreezing hydrogel electrolyte enables Zn–I2 batteries with complete and reversible four-electron-transfer mechanisms at low temperatures. ANGEW, 64(21), e202502005. (www)

  @article{ , abstract = {Four-electron-transfer aqueous zinc–iodine batteries hold significant promise for large-scale energy storage due to their high specific capacities. However, achieving four-electron-transfer mechanisms under subzero temperatures remains challenging due to freezing point limitations of conventional aqueous electrolytes and sluggish reaction kinetics. Herein, an antifreezing hydrogel electrolyte (HC-SiO 2 ) is developed through the spontaneous gelation of a high-concentration electrolyte (1 m Zn(OAc) 2 + 21 m LiCl, HC) with SiO 2 nanoparticles, enabling low-temperature operation of quasi-solid-state Zn–I 2 batteries with complete and reversible four-electron-transfer processes. Abundant interactions between dispersed SiO 2 nanoparticles and cations enlarge ion-pair distances, reducing close ion-pair formation and lowering the freezing temperature (−60.7 °C). Furthermore, the quasi-solid-state hydrogel electrolyte combines advantages of reduced water activity and disrupted hydrogen-bond networks, effectively suppressing I + hydrolysis while inhibiting ice nucleation. Additionally, the utilization of low-concentration Zn(OAc) 2 combined with high-concentration LiCl increases availability of free Cl − by mitigating strong ionic interaction in conventional ZnCl 2 -based concentrated electrolytes, thereby enhancing reaction kinetics of the I 2 /I + conversion. Benefiting from synergistic manipulation of ionic interaction, water activity, and Cl − activity, the HC-SiO 2 hydrogel achieves a high capacity of 490.9 mAh g −1 and durable lifespan exceeding 11,000 cycles at −20 °C. These findings offer valuable insights for advancing practical low-temperature Zn–I 2 batteries.}, archive = {J_ANGEW}, author = {Minghui Chen and Guanhong Chen and Chenxi Sun and Xinyu Li and Minghao Zhang and Haiming Hua and Jinbao Zhao and Yang Yang}, doi = {10.1002/anie.202502005}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502005}, shortjournal = {Angew. Chem. Int. Edit.}, title = {SiO2 nanoparticles-induced antifreezing hydrogel electrolyte enables Zn–I2 batteries with complete and reversible four-electron-transfer mechanisms at low temperatures}, volume = {64}, year = {2025}, }
• (2025). A titanium silicalite-1 (TS-1) catalyst with abundant active ti-VI species for efficient conversion of ethylene to glycol. ANGEW, 64(21), e202502003. (www)

  @article{ , abstract = {One-pot synthesis of glycol from ethylene and H 2 O 2 is simple and environmentally friendly, making it a potential alternative for glycol production. The key to the success of this is to have a bifunctional catalyst with both oxidative activity for ethylene epoxidation and acidic centers for the hydration of ethylene oxide. Typically, the incorporation of trivalent metal ions into titanium silicalite-1 (TS-1) framework can provide the two types of active centers, but this often results in decreased oxidative activity. Here, we propose a dual-chemical post-treatment regime to introduce acid centers in TS-1 while simultaneously improving oxidative activity. The combined tetrapropylammonium hydroxide (TPAOH) + (NH 4 ) 2 CO 3 post-treatment not only produces abundant Ti(OSi) 2 (OH) 4 (Ti-VI) species from Ti(OSi) 4 , but also creates internal cavities within TS-1. Ti-VI possesses both high oxidative activity and acidic sites. The presence of internal cavities enhances the diffusion on the catalyst as well as increases the accessibility of Ti-VI species. Consequently, when applied as a catalyst, the combined-treated TS-1 demonstrates an outstanding catalytic performance, achieving 98.6 % conversion of H 2 O 2 and 99.8 % selectivity of EG, which is ≈2 times of the conventional TS-1. This study also unveils the formation mechanism of Ti-VI during the post-treatment.}, archive = {J_ANGEW}, author = {Huali Tan and Yi Zuo and Gudan Li and Bosong Zhang and Lina Li and Lingling Guo and Jianrong Zeng and Fei Song and Hong Yang and Xinwen Guo}, doi = {10.1002/anie.202502003}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202502003}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A titanium silicalite-1 (TS-1) catalyst with abundant active ti-VI species for efficient conversion of ethylene to glycol}, volume = {64}, year = {2025}, }
• (2025). Engineering solvent-coordinated Heterometallic–Organic frameworks for wide-range tuning of ultralong room temperature phosphorescence toward time-resolved anticounterfeiting. ANGEW, 64(21), e202501951. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) have been proven promising ultralong room temperature phosphorescence (RTP) materials for anticounterfeit due to their unique optical properties. However, it remains a major challenge to achieve the desired phosphorescent properties due to the limited regulatory methods and indistinct mechanism. Herein, the coordination solvent and second metal ion costrategy is firstly proposed to prepare seven robust heterometallic–organic frameworks (HMOFs) with two configurations, ZnMg/Ca-sol [sol = H 2 O, dimethylformamide (DMF), dimethylacetamide (DMA), and formyldiethylamine (DEF)] and ZnSr/Ba-H 2 O , exhibiting different ultralong RTP. The tunable phosphorescence lifetimes within 14.5–195.4 ms are achieved gradually by altering the type of alkaline earth metals, coordination solvent, and hydrogen-bonding in the HMOFs. Significantly, the theoretical calculations reveal that the promotion of spin–orbit coupling by heavy metals and the rigid constraint on the skeleton by solvent result in excellent balance between high phosphorescence quantum yield ( Ф P ) and long lifetime, especially for ZnSr-H 2 O (6.8%, 195.4 ms). Depending on the wide-range tuning of ultralong RTP and great stability, the HMOFs are successfully applied in spatial-time resolved anticounterfeiting and multilevel information encryption. This work may provide a new approach to designing target phosphorescent materials while resolving the contradiction between high Ф P and long lifetime.}, archive = {J_ANGEW}, author = {Juanjuan Xue and Zhenhong Qi and Dongpeng Yan and Guo-Ping Yang and Yao-Yu Wang}, doi = {10.1002/anie.202501951}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501951}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering solvent-coordinated Heterometallic–Organic frameworks for wide-range tuning of ultralong room temperature phosphorescence toward time-resolved anticounterfeiting}, volume = {64}, year = {2025}, }
• (2025). Reversible CO2 hydrogenation, neutron crystallography, and hydride reactivity of a triiridium heptahydride complex. ANGEW, 64(21), e202501943. (www)

  @article{ , abstract = {The authors report the structure, reactivity, and catalytic utility of a triiridium complex, [Ir 3 H 6 ( μ 3 -H)(PN) 3 ] 2+ ( 2-H , PN = (2-pyridyl)CH 2 PBu t 2 ). Despite its unusual stability to unsaturated organics, electrophiles, and even CF 3 SO 3 D, they find that complex 2-H catalyzes hydrogenation of CO 2 to formate (TON Ir = 9600) and reverse formic acid dehydrogenation (TON Ir = 54 400). The hydrogenation operates via a reactive intermediate [Ir 3 H 4 ( μ -H) 4 (PN) 3 ] + ( 5 ). Neutron crystallography and DFT-supported neutron vibrational spectroscopy of 2-H reveal Ir─H bond lengths and elucidate the vibration modes within the Ir 3 H 7 core. Stoichiometric oxidation of 2-H produces four classes of iridium complexes of varied nuclearity and hydride structure: tetra- and pentanuclear clusters [Ir 3 H 6 ( μ 3 -AuPPh 3 )(PN) 3 ] 2+ ( 2-Au ) and [Ag{Ir 2 H 4 ( μ -OAc)(PN) 2 } 2 ] 3+ ( 6 ) are generated using AuPPh 3 + and AgOAc, respectively. Further oxidation to class [Ir 2 H 3 ( μ -X) 2 (PN) 2 ] + is possible with AgOAc, Hg(OAc) 2 , or I 2 . Finally, a TEMPO/HCl system completely oxidizes the hydrides and gives [Ir 2 Cl 4 ( μ -Cl) 2 (PN) 2 ] ( 11 ).}, archive = {J_ANGEW}, author = {Valeriy Cherepakhin and Van K. Do and Anthony J. Chavez and Jacob Kelber and Ryan A. Klein and Eric Novak and Yongqiang Cheng and Xiaoping Wang and Craig M. Brown and Travis J. Williams}, doi = {10.1002/anie.202501943}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501943}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversible CO2 hydrogenation, neutron crystallography, and hydride reactivity of a triiridium heptahydride complex}, volume = {64}, year = {2025}, }
• (2025). Synergistic assembly of single-crystal 2D porphyrin-based organic polymers via dative B─N bonds and halogen bonds. ANGEW, 64(21), e202501875. (www)

  @article{ , abstract = {The rigorous synthetic methodologies have significantly impeded the progress in developing single-crystal extended organic polymers. Notably, the existence of macroscopic single-crystalline 2D porphyrin-based organic polymers has never been documented in the literature until now. In this study, we present a groundbreaking example of single-crystal 2D porphyrin-based organic polymers that are compatible with single-crystal X-ray diffraction (SXRD) for precise structural elucidation. Their formation is fundamentally dependent on the synergistic assembly facilitated by dative B─N bonds and halogen bonds. These crystals exhibit remarkable stability in both air and aqueous environments. Notably, the formation of the B–N Lewis pairs within these crystals significantly enhances the separation of photogenerated carriers, and their single crystals demonstrate exceptional photocatalytic activity for the production of hydrogen peroxide (H 2 O 2 ) from water and oxygen, without the requirement for sacrificial agents. This pioneering discovery establishes a new approach for crystalline control within the realm of organic polymers.}, archive = {J_ANGEW}, author = {Furong Yuan and Guanrui Han and Chenxin Chen and Xi Fan and Shengchang Xiang and Zhangjing Zhang}, doi = {10.1002/anie.202501875}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501875}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic assembly of single-crystal 2D porphyrin-based organic polymers via dative B─N bonds and halogen bonds}, volume = {64}, year = {2025}, }
• (2025). Electron itinerancy mediated by oxygen vacancies breaks the inert electron chain to boost Lithium–Oxygen batteries electrocatalysis. ANGEW, 64(21), e202501837. (www)

  @article{ , abstract = {The synergistic effect of dopants and oxygen vacancies (V o ) in metal oxides is crucial for enhancing the adsorption and electron transfer processes in lithium–oxygen (Li–O 2 ) batteries; however, the underlying mechanisms remain unclear. Herein, Ru single-atom-modified TiO 2 nanorod array (Ru 1 –TiO 2− x ) electrocatalysts with abundant V o were fabricated, serving as an efficient catalyst for Li–O 2 batteries. Experimental and theoretical investigations have demonstrated that V o functions as an “electron pump”, facilitating electron itinerant behavior, while Ru 1 serves as an “electron buffer” to further activate the [Ru–O–Ti] electronic chain. This synergistic interplay endows Li–O 2 batteries with a highly active and stable bidirectional self-regulating capability during the process of circulation, exhibiting an ultra-low charge polarization (0.42V) and exceptional cycling stability (1680 h). V o and Ru 1 synergistically modulate the d -band center at the Ti site to establish an adaptively tunable Ru–Ti dual-active site. This adjustment effectively balances the binding strength with the interface oxygen intermediate ( * O), thereby significantly reducing the activation barrier. The Hamiltonian layout further revealed the crucial role of remote orbital coupling in maintaining the structural stability. This study not only provides profound insights into V o -dependent electron transfer kinetics but also proposes new strategies and theoretical guidance for the activation of inert materials.}, archive = {J_ANGEW}, author = {Yaning Fu and Chunmei Liu and Lina Song and Shaoze Zhao and Mengyao Huang and Zhongjun Li and Huabiao Tang and Youcai Lu and Jijing Xu and Qingchao Liu}, doi = {10.1002/anie.202501837}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501837}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron itinerancy mediated by oxygen vacancies breaks the inert electron chain to boost Lithium–Oxygen batteries electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Laser-polarization-induced anisotropy enhances protein crystallization. ANGEW, 64(21), e202501827. (www)

  @article{ , abstract = {Protein crystallization plays a critical role in structural biology and drug development, driving extensive research into its control. We present a novel approach for manipulating protein crystallization by controlling the anisotropy of the high-concentration domain (HCD) composed of hen egg-white lysozyme (HEWL) through laser polarization in optical trapping. The anisotropy of the HCD was assessed through fluorescence anisotropy measurements and polarized Raman spectroscopy. The results revealed that linear polarization significantly enhances crystallization efficiency by inducing anisotropy of the HCD and promoting nucleation. In contrast, circular polarization resulted in weak anisotropy with minimal crystallization efficiency. This study highlights the crucial role of protein molecule anisotropy in crystallization under optical trapping conditions, providing a new strategy to optimize laser conditions for various protein molecules and pave the way for the development of innovative crystallization techniques, potentially revolutionizing structural biology and drug discovery efforts.}, archive = {J_ANGEW}, author = {Tien Chen and Hirotsugu Hiramatsu and Shuichi Toyouchi and Teruki Sugiyama}, doi = {10.1002/anie.202501827}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501827}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Laser-polarization-induced anisotropy enhances protein crystallization}, volume = {64}, year = {2025}, }
• (2025). Unlocking reactivity of unprotected oximes via green-light-driven dual Copper/Organophotoredox catalysis. ANGEW, 64(21), e202501806. (www)

  @article{ , abstract = {Oximes are widely used precursors in synthetic chemistry due to their broad availability and versatile chemical properties, in which N─O bond fragmentation represents a key reactivity mode. However, these transformations typically require the use of oxygen-protected oximes, and a general strategy to directly utilize free oximes remains challenging due to their vulnerability to side reaction pathways, rendering low tendency towards N─OH bond cleavage. Here a unified platform is reported to achieve direct cyclization of unprotected oximes with enals, as well as other coupling partners through dual copper/organophotoredox catalysis under green light irradiation. This protocol enables concurrent activation of both N─OH and α -C(sp 3 )─H bonds of free oximes to form multisubstituted pyridines with exceeding structural diversity and functional group tolerance. In this process, Rose Bengal serves as a hydrogen atom transfer agent to generate radical intermediates. In the meanwhile, copper catalyst activates of free oximes via single-electron reduction-induced N─O bond fragmentation and controls the selectivity for intermediate trapping. The synthetic utility of this approach is further demonstrated by its successful applications in late-stage modification of biologically active compounds and rapid assembly of solvatochromic fluorescent materials.}, archive = {J_ANGEW}, author = {Shuping Wang and Yaping Shang and Mengqi Wang and Jiawen Lai and Xiaoming Jie and Weiping Su}, doi = {10.1002/anie.202501806}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501806}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking reactivity of unprotected oximes via green-light-driven dual Copper/Organophotoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Near-infrared chemiluminescent theranostics. ANGEW, 64(21), e202501681. (www)

  @article{ , abstract = {Molecular chemiluminescence probes with near-infrared (NIR) emission offer promising benefits in deciphering complex pathological processes in a living system, as NIR chemiluminescence minimizes autofluorescence, enhances deep-tissue penetration, and improves signal-to-noise ratio. Molecular engineering using single-luminophore design and dual-luminophore design with intramolecular energy transfer provides ways to develop conventional chemiluminophore scaffolds into NIR chemiluminescence probes with ideal chemiluminescence quantum yield and half-life. By virtue of the structural diversity, 1,2-dioxetane-based NIR chemiluminophores with biomarker activity have been developed. This review summarizes the molecular design strategies of NIR chemiluminescence theranostic probes (NCTPs), followed by introducing activatable NCTPs with their biomedical applications for disease theranostics. Lastly, future perspectives and potential challenges of NIR chemiluminescence imaging in preclinical research and clinical translational potential are discussed.}, archive = {J_ANGEW}, author = {Youshi Lin and Jingsheng Huang and Kanyi Pu}, doi = {10.1002/anie.202501681}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501681}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared chemiluminescent theranostics}, volume = {64}, year = {2025}, }
• (2025). Quasi-industrial preparation of SWCNTs-confined high-entropy oxides as self-supported electrodes for continuous electrosynthesis. ANGEW, 64(21), e202501669. (www)

  @article{ , abstract = {High-entropy oxides (HEOs) are emerging as highly promising materials for electrochemical applications due to their exceptional electronic properties and active sites. However, the synthesis of 1D HEO with high aspect ratios and mechanical properties has been challenging, particularly on an industrial scale. Herein, we report a spatially confined oxidation (SCO) method to synthesize 1D HEO@SWCNTs with high specific surface area and stability. This method enables the large-scale production of HEO@SWCNTs, achieving quasi-industrially quantities in a single batch, and can be extended to seven-element 1D HEO. The resulting exhibit a homogeneous distribution of elements and a single-phase solid solution structure, as confirmed by STEM-EDS and XRD analysis. The Fermi level of SWCNTs is downshifted into the valence band upon HEO doping, enhancing conductivity and electrochemical activity. The HEO@SWCNTs electrode demonstrates superior flexibility and self-supported properties, making it suitable for large-scale electrochemical applications. Chronoamperometric measurements reveal excellent stability, maintaining 94% current retention after 20 h. Notably, in the electrochemical epoxidation reaction cycloolefin, the HEO@SWCNTs self-supported electrode achieves an average FE of 70.7% for epoxy-cyclohexane over 24 h. This work provides a scalable and versatile approach to the synthesis of self-supported electrodes for advanced electrochemical systems.}, archive = {J_ANGEW}, author = {Minxing Du and Junyi Du and Huili Fu and Lin Geng and Xiaoxuan Xie and Chengxu Zhou and Yunlei Zhong and Yong Zhang and Dan Tian and Lixing Kang}, doi = {10.1002/anie.202501669}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quasi-industrial preparation of SWCNTs-confined high-entropy oxides as self-supported electrodes for continuous electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Ultralow thermal conductivity in halogen-doped PbSnS2 with optimized thermoelectric properties. ANGEW, 64(21), e202501667. (www)

  @article{ , abstract = {Here, we investigate PbSnS 2 , a wide band gap (1.13 eV) compound, as a promising thermoelectric material for power generation. Single crystal X-ray diffraction analysis reveals its 2D-layered structure, akin to the GeSe structure type, with Pb and Sn atoms sharing the same crystallographic site. The polycrystalline PbSnS 2 exhibits an intrinsically ultralow lattice thermal conductivity ( κ lat ) of 0.37 W m −1 K −1 at 573 K. However, the low carrier concentration ( n ) leads to suboptimal electrical conductivity ( σ ), capping the ZT value at 0.1. Accordingly, the halogen elements (Cl, Br, and I) are employed as the n-type dopants to improve the n . The DFT results indicate a significant weakening of Pb/Sn─S bonds upon halogen-doping, contributing to the observed reduction in κ lat . Our analysis indicates the activation of multiconduction band transport driven by halogen substitution. The PbSnS 1.96 Br 0.04 has a high power factor of five times that of intrinsic PbSnS 2 . Halogen-doping weakens the Pb/Sn─S bonds and enhances the phonon scattering, leading to an ultralow κ lat of 0.29 W m −1 K −1 at 873 K for PbSnS 1.96 Br 0.04 . Consequently, PbSnS 1.96 Br 0.04 achieved a maximum ZT value of 0.82 at 873 K.}, archive = {J_ANGEW}, author = {Zixuan Chen and Hongwei Ming and Zhi Li and Steven N. Girard and Collin D. Morris and Weiping Guo and Ming Wu and Yan Yu and Christopher Wolverton and Zhong-Zhen Luo and Zhigang Zou and Mercouri G. Kanatzidis}, doi = {10.1002/anie.202501667}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultralow thermal conductivity in halogen-doped PbSnS2 with optimized thermoelectric properties}, volume = {64}, year = {2025}, }
• (2025). Biomimetic localized gel electrolyte for practical zinc anode. ANGEW, 64(21), e202501664. (www)

  @article{ , abstract = {Incompatible electrode/electrolyte interface often leads to dendrite growth, parasitic reactions, and corrosion, posing significant challenges to the application of Zn anodes. Herein, we introduce a biomimetic antifreeze protein localized gel electrolyte (ALGE) with multifunctional capabilities to address these issues by combining electrolyte modification with interface optimization. ALGE modifies the Zn 2+ solvation structure and the hydrogen-bond network adjacent to the zinc anode, effectively suppressing hydrogen evolution. Additionally, ALGE promotes (002) Zn crystal plane-dominated deposition by protein-zinc surface interactions, enabling a long-range dendrite-free deposition. The absence of by-products and inhibited corrosion further highlights the practical potential of ALGE. Symmetric cells with ALGE-modified zinc demonstrate an impressive lifespan of 610  h under a current density of 10 mA cm −2 and a capacity of 10 mAh cm −2 . The pouch cell integrating a manganese dioxide cathode and ALGE-modified Zn anode retains 75.8% of its capacity after 200 cycles at 1 A g −1 . This localized gel electrolyte strategy offers a practical and scalable approach to stabilizing Zn anodes for next-generation energy storage systems.}, archive = {J_ANGEW}, author = {Yibo Zhu and Shengyong Gao and Shuangbin Zhang and Yang Chen and Peng Liu and Haotian Meng and Zhiruo Luo and Xuan Chen and Zhenhai Wen and Lina Wang and Lianzhou Wang and Bin Luo and Jisheng Zhou}, doi = {10.1002/anie.202501664}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biomimetic localized gel electrolyte for practical zinc anode}, volume = {64}, year = {2025}, }
• (2025). Simultaneous activation of bicyclobutanes and indolyl alcohols with HFIP: Access to indole-fused Bicyclo[3.1.1]Heptanes. ANGEW, 64(21), e202501655. (www)

  @article{ , abstract = {The concept of strain release to unleash unique reactivity that drives a wide range of synthetically valuable transformations has long intrigued chemists. Among the various strained systems, highly reactive bicyclo[1.1.0]butanes (BCBs) have recently emerged as versatile building blocks for constructing bicyclic scaffolds. Despite the existence of various activation pathways for BCBs, the use of 1,1,1,3,3,3-hexafluoroisopropan-2-ol (HFIP) to activate BCBs has not been realized so far. Herein, we report the first HFIP-promoted (3 + 3) annulation of BCBs with indolyl alcohols through the simultaneous activation of both partners, facilitating the metal- and photocatalyst-free synthesis of indole-fused bicyclo[3.1.1]heptanes. Mechanistic studies reveal the role of HFIP in activating both components, and the reaction proceeds by an initial (3 + 2) annulation followed by a ring expansion/aromatization cascade.}, archive = {J_ANGEW}, author = {Shiksha Deswal and Rohan Chandra Das and Deeptanu Sarkar and Akkattu T. Biju}, doi = {10.1002/anie.202501655}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501655}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous activation of bicyclobutanes and indolyl alcohols with HFIP: Access to indole-fused Bicyclo[3.1.1]Heptanes}, volume = {64}, year = {2025}, }
• (2025). A site-specific photo-crosslinking proteomics approach provides insights into noncanonical pyroptotic caspase-4 substrates. ANGEW, 64(21), e202501535. (www)

  @article{ , abstract = {Inflammatory caspases (1/4/5) are key effectors in the process of pyroptosis by cleaving and activating the pore-forming protein gasdermin D (GSDMD). Unlike other caspases whose substrates have been well characterized, the substrates for caspase-4, which mediate noncanonical pyroptosis, remain poorly understood. Here, we combined noncanonical amino acids, photo-crosslinking, and proteomics to profile caspase-4 substrates, enabling the capture of transient protein interactions with activated caspase-4. A set of new substrates were identified by photo-crosslinking mass spectrometry, revealing the signaling pathway and biological process affected by pyroptosis. Notably, we found that AKT1 is cleaved at D108, which removes its autoinhibition and membrane localization domain, resulting in the release of activated AKT1. Our results also showed the precursor of caspase-5/12 could be cleaved by caspase-4 to form the p20/p10 active conformation, uncovering a previously unrecognized pyroptotic caspase cascade. Overall, this study presents an approach for identifying caspase-4 substrates and offers further understanding of noncanonical pyroptosis.}, archive = {J_ANGEW}, author = {Yi Zhou and Xinyu Zhang and Hang Yin}, doi = {10.1002/anie.202501535}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501535}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A site-specific photo-crosslinking proteomics approach provides insights into noncanonical pyroptotic caspase-4 substrates}, volume = {64}, year = {2025}, }
• (2025). Thermally conductive naphthalene epoxy resin by tailoring flexible chain length and liquid crystal structure. ANGEW, 64(21), e202501459. (www)

  @article{ , abstract = {Epoxy resins with high thermal conductivity ( λ ) are widely used in electronic packaging, bonding, and coating. However, those with high intrinsic λ , typically synthesized using biphenyl or aromatic rings extended by ester linkages as the mesogenic unit, often exhibit high liquid crystal transition temperatures and poor processability. In this study, a series of naphthalene-based liquid crystal epoxy monomers (LCEs) were synthesized, using naphthalene as the mesogenic unit and modifying the flexible chain length on both sides. The resulting LCEs were cured within its liquid crystal phase to form naphthalene liquid crystal epoxy resin (LCER). The results show that the network order, radius of gyration, and low-frequency vibrational density of states all initially increase and then decrease with increasing flexible chain length. For LCER 2 , with a three-carbon flexible chain, these parameters reach their maximum values, facilitating phonon diffusion and enhancing λ . The liquid crystal transition temperature, λ , heat resistance index, and storage modulus of LCER 2 were 67–78 °C, 0.40 W m −1 K −1 , 158.8 °C, and 2059 MPa, respectively, approximately 2.2 times higher than that of E-51 resin (0.18 W m −1 K −1 ). This work offers insights into designing epoxy resins with low liquid crystal transition temperature, high intrinsic λ , and excellent mechanical properties for thermal management.}, archive = {J_ANGEW}, author = {Shuangshuang Wang and Kunpeng Ruan and Yongqiang Guo and Jie Kong and Junwei Gu}, doi = {10.1002/anie.202501459}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermally conductive naphthalene epoxy resin by tailoring flexible chain length and liquid crystal structure}, volume = {64}, year = {2025}, }
• (2025). Perovskite-coupled NIR organic hybrid solar cells achieving an 84.2% fill factor and a 25.2% efficiency: A comprehensive mechanistic exploration. ANGEW, 64(21), e202501375. (www)

  @article{ , abstract = {The integration of organic dyes in perovskite solar cells (PSCs) to utilize near-infrared (NIR) photons remains a challenge. In this study, a selenium-incorporated ortho-benzodipyrrole-based NIR dye CB-2Se was developed. CB-2Se, featuring a lower bandgap of 1.35 eV, was blended with PCBM to form a bulk-heterojunction layer in PSCs for electron extraction and transport. Compared to Y6-16 acceptor, the removal of the Tz unit in CB-2Se suppresses self-aggregation, improving its compatibility with PCBM. A CB-2Se:PCBM-incorporated PSC achieved a remarkable power conversion efficiency (PCE) of 25.18% with a V OC of 1.164 V, a J SC of 25.71 mA/cm 2 , a Fill Factor of 84.15%, outperforming that of the PCBM-only reference device (24.35%) and the PCBM:Y6-16-based device (24.49%). The PCBM:CB-2Se layer enhanced the long-term stability of PSCs, retaining 88% of its initial efficiency after 1000 h under ambient air and thermal conditions. The photophysical interactions between NIR dyes and PSCs have been comprehensively investigated by using femtosecond transient absorption spectroscopy. Ultrafast exciton separation into free charges occurs within 200 femtoseconds at the interfaces between PCBM and CB-2Se. For the first time, a transfer of holes from CB-2Se back to the perovskite was detected, providing valuable insights into the charge dynamics of PSCs utilizing NIR dyes.}, archive = {J_ANGEW}, author = {Chieh-Ming Hung and Chia-Jen Chih and Kuo-Hsiu Huang and Yung-Jing Xue and Heng-Chi Chu and Chi-Chun Tseng and Chun-Hao Li and Jiann-Yeu Chen and Bo-Han Chen and Shang-Da Yang and Yen-Ju Cheng and Pi-Tai Chou}, doi = {10.1002/anie.202501375}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501375}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Perovskite-coupled NIR organic hybrid solar cells achieving an 84.2% fill factor and a 25.2% efficiency: A comprehensive mechanistic exploration}, volume = {64}, year = {2025}, }
• (2025). Revealing kinetic features of a macrocyclization reaction using machine-learning-augmented data. ANGEW, 64(21), e202501365. (www)

  @article{ , abstract = {We developed a method to reveal the kinetic features of macrocyclization using machine-learning-augmented data. Thirty-six experimental yield datasets were expanded to two hundred datasets through machine learning, enabling kinetic analyses of concentration-dependent yields. This augmented data allowed the chemistry underlying the predictive black box to be elucidated, providing quantitative insights such as rate constants and effective molarity through least-squares fitting of differential rate equations. These quantitative measures offered physicochemical explanations for the optimal conditions identified by the machine learning. Additionally, linear relationships between effective molarity and strain energy were found, highlighting key aspects of oligomeric macrocyclization via nickel-mediated coupling.}, archive = {J_ANGEW}, author = {Hiroyuki Isobe and Xinyi Xiao and Toshiya M. Fukunaga and Koki Ikemoto}, doi = {10.1002/anie.202501365}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501365}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing kinetic features of a macrocyclization reaction using machine-learning-augmented data}, volume = {64}, year = {2025}, }
• (2025). Simultaneous manipulation of anions and water molecules by lewis Acid–Base for highly stable zn anodes. ANGEW, 64(21), e202501327. (www)

  @article{ , abstract = {In aqueous zinc-ion batteries (ZIBs), Zn anodes often suffer from Zn dendrite and hydrogen evolution reaction (HER) in traditional electrolytes. Herein, fumed silica with both Lewis acid–base functional groups were introduced into traditional electrolytes. Owing to the strong Lewis acid–base interactions between Si─O─Si functional groups and SO 4 2− ions, the Zn 2+ ion transference number is significantly increased in electrolyte, and thus more Zn 2+ ions reach the Zn anode surface. As a result, the distribution of Zn 2+ ions will be more homogeneous and dendrites growth will be suppressed on the Zn anode surface. In addition, Si─OH functional groups on fumed silica can also constrain the free and solvated H 2 O molecules in electrolyte simultaneously through Lewis acid–base interactions between electronegative O atoms in Si─OH functional groups and electropositive H atoms in H 2 O molecules, ensuring that the HER is inhibited on Zn anodes. Therefore, in the fumed silica-contained electrolyte, the Zn anodes exhibit a high reversibility and Zn||MnO 2 full batteries demonstrate a superior cycling performance.}, archive = {J_ANGEW}, author = {Rui Wang and Jiacai Zhu and Min Yang and Zhiqiang Niu}, doi = {10.1002/anie.202501327}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous manipulation of anions and water molecules by lewis Acid–Base for highly stable zn anodes}, volume = {64}, year = {2025}, }
• (2025). Synergistic catalysts with fe single atoms and Fe3C clusters for accelerated oxygen adsorption kinetics in oxygen reduction reaction. ANGEW, 64(21), e202501266. (www)

  @article{ , abstract = {The design of cost-effective and efficient catalysts based on transition metal–based electrocatalysts for the oxygen reduction reaction (ORR) is crucial yet challenging for energy-conversion devices like metal–air batteries. In this work, we present a cost-effective strategy for preparing catalysts consisting of single-atomic Fe sites and Fe 3 C clusters encapsulated in nitrogen-doped carbon layers (FeSA-Fe 3 C/NC). The FeSA-Fe 3 C/NC electrocatalyst demonstrates outstanding ORR performance in alkaline electrolytes, achieving a high half-wave potential ( E 1/2 = 0.902 V), 4e − ORR selectivity, and robust methanol tolerance. The exceptional ORR catalytic performance is credited to the relatively substantial specific surface area and the optimal arrangement of active sites, including atomically dispersed Fe–N sites and synergistic Fe 3 C clusters. In situ spectroelectrochemical characterization and theoretical calculations verify that Fe 3 C clusters disrupt the symmetric electronic structure of Fe–N 4 , optimizing 3d orbitals of Fe centers, thereby accelerating O─O bond cleavage in *OOH to boost ORR activity. Furthermore, a zinc–air battery constructed with FeSA-Fe 3 C/NC demonstrates excellent potential in energy storage application, yielding a maximum power density of 151.3 mW cm −2 and robust cycling durability surpassing that of commercial Pt/C catalysts. This study establishes a cost-effective route for producing metal-based carbon electrocatalysts with exceptional performance using environmentally friendly raw materials.}, archive = {J_ANGEW}, author = {Chunlian Liu and Ruizhe Yang and Jiacheng Wang and Bowen Liu and Xiaowan Chang and Pingxian Feng and Xuanzhen Zhang and Lijie Zhong and Xiaoli Zhao and Li Niu and Shiyu Gan and Yuebin Xi and Ming Huang and Huan Wang}, doi = {10.1002/anie.202501266}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501266}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic catalysts with fe single atoms and Fe3C clusters for accelerated oxygen adsorption kinetics in oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Customizing room-temperature perovskite ferroelectrics toward the multichannel domain manipulation. ANGEW, 64(21), e202501238. (www)

  @article{ , abstract = {Manipulating domain structure in ferroelectrics by external stimuli presents a fascinating avenue for new-generation electronic devices. However, multichannel controlling of ferroelectric domains is still a challenge, due to the lack of knowledge on their bistability to diverse physical stimuli. Herein, we have customized a series of perovskite ferroelectrics, (C n H 2n+1 NH 3 ) 2 (CH 3 NH 3 ) 2 Pb 3 Br 10 ( n = 2–7), of which the Curie temperatures are modulated in a wide temperature range (Δ T = 74 K) by tailoring chain length of organic spacers. Strikingly, the n = 7 member is a room-temperature ferroelectric with bistable characteristics, thus endowing the manipulation of domains via four channels (i.e., thermal, stress, light, and electric fields). Such a non-volatile memory behavior of the stress-switching domain is unprecedented in hybrid perovskite ferroelectrics. This manipulation of domains reveals the unique bistability of its ferroelectric orders, which sheds light on the future advance of customizing electric-ordered materials toward smart device applications.}, archive = {J_ANGEW}, author = {Haojie Xu and Wuqian Guo and Yi Liu and Yu Ma and Qingshun Fan and Liwei Tang and Wenjing Li and Huaimin Ni and Junhua Luo and Zhihua Sun}, doi = {10.1002/anie.202501238}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501238}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Customizing room-temperature perovskite ferroelectrics toward the multichannel domain manipulation}, volume = {64}, year = {2025}, }
• (2025). A key fragment in carbon schwarzite unit cells and its triple [6]Helicene precursor. ANGEW, 64(21), e202501169. (www)

  @article{ , abstract = {This study explores two structurally related π-skeletons. The π-skeleton of compounds 1a–e containing three heptagons represents a key fragment in theoretical carbon schwarzites, while that of 2a–b is a triple [6]helicene. Compounds 1a–e were synthesized via Scholl reactions, and using a weaker acid allowed the reaction to stop at an intermediate stage, yielding 2a–b . X-ray crystallography revealed not only distinct stereochemistry of 1b and 2a but also unique supramolecular assemblies in the clathrate of 2a with chloroform. Compound 1b adopts a saddle-like geometry, while 2a exhibits a propeller-like structure with C 3 symmetry, consistent with density functional theory (DFT) calculations. The π-skeleton of 1a–e is flexible, enabling rapid enantiomerization, whereas that of 2a–b is rigid, allowing resolution of 2b into optically pure forms with an absorption dissymmetry factor as high as 0.015. Comparative analysis shows that presence of seven-membered rings in 1a–e does not significantly alter the local aromaticity of the triple [6]helicene framework.}, archive = {J_ANGEW}, author = {Xinhe Yang and Shilong Su and Chenyu Hu and Ka Man Cheung and Daiyue Yang and Xiao Chen and Jun Yang and Zhifeng Huang and Fuk Yee Kwong and Qian Miao}, doi = {10.1002/anie.202501169}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A key fragment in carbon schwarzite unit cells and its triple [6]Helicene precursor}, volume = {64}, year = {2025}, }
• (2025). Graphene nanoribbon core thermotropic liquid crystal with a well-defined molecular structure. ANGEW, 64(21), e202501161. (www)

  @article{ , abstract = {Graphene nanoribbons (GNRs) with hierarchical and well-ordered structures are believed to deliver superior performance in semiconductor device applications. Despite this potential, traditional alignment techniques for GNRs often fall short in producing defect-free and precisely defined molecular architectures. Here, we introduce a strategy for the fabrication of highly ordered GNR by empowering them with thermotropic liquid crystallinity, utilizing a bottom-up solution synthesis approach. The resulting GNR liquid crystal ( GNR-LC ) molecule can self-assemble into a hexagonal columnar phase. The homeotropic alignment of GNR-LC is enabled by the intrinsic self-assembly capabilities of the thermotropic liquid crystalline state, thereby forming 1D charge transport pathways. Devices incorporating GNR-LC have demonstrated significantly enhanced hole mobility, reaching up to 2.4 cm 2 V −1 s −1 , underscoring their viability as organic semiconductors for optoelectronic applications.}, archive = {J_ANGEW}, author = {Jun Hu and Zhen Yu and Yong Yang and Jiaxiang Huang and Zhiyang Liu and Shuai Huang and Meng Wang and Hong Yang}, doi = {10.1002/anie.202501161}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Graphene nanoribbon core thermotropic liquid crystal with a well-defined molecular structure}, volume = {64}, year = {2025}, }
• (2025). A crystalline polymer cathode for sodium-organic batteries. ANGEW, 64(21), e202501134. (www)

  @article{ , abstract = {Sodium-organic batteries (SOBs) are widely recognized as a rising star in large-scale energy storage technology because of their abundant resources, high energy density, and environmental friendliness. However, the poor cyclability and rate performance due to high solubility and poor conductivity with organic electrode materials limit their practical applications. Here, we constructed a new crystalline polymer, poly(tetraaminobenzoquione) (PTABQ), featuring a layered structure with a conjugated backbone and intermolecular hydrogen bonds. Benefiting from the crystalline structure with one-dimensional O-channels and highly conjugated backbone, PTABQ shows high electronic conductivity (10 −7 S cm −1 ) and fast ion diffusion ability (∼10 −8 cm 2 s −1 ). PTABQ displays a discharge capacity of 380 mAh g −1 with an average voltage of 2.0 V and nearly 90% capacity retention after ultra-long 2800 cycles at 3 A g −1 (∼8 C), which is superior to the reported organic cathode materials. It also exhibits an impressive rate performance of 290 mAh g −1 at 8 A g −1 (∼20 C). Our work highlights the importance of constructing the crystal structure for effective utilization of active sites and fast ion diffusion, which sheds light on the development of an efficient and sustainable energy storage system.}, archive = {J_ANGEW}, author = {Mengyuan Zeng and Youxuan Ni and Yixin Li and Weichao Cheng and Zirui Shao and Xin Feng and Zixuan Niu and Qi Zhao and Yu-An Li and Haixia Li and Weiwei Xie and Yong Lu and Zhenhua Yan and Kai Zhang and Jun Chen}, doi = {10.1002/anie.202501134}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202501134}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A crystalline polymer cathode for sodium-organic batteries}, volume = {64}, year = {2025}, }
• (2025). Synthesis of abiotic supramolecular polymers inside living cells via organocatalysis-mediated self-assembly. ANGEW, 64(21), e202500998. (www)

  @article{ , abstract = {Cells execute mesmerizing functions using supramolecular polymers (SPs) formed through the self-assembly of biological precursors. Integration of the vast array of synthetic SPs with living cells would offer a powerful way to remold cellular functions and bridge the gap between synthetic materials and the biological realm, yet remains a challenge because of the lack of robust abiotic SP systems that can be triggered to self-assemble inside cells. Here, we report how fully abiotic SPs can be synthesized inside living cells via an organocatalysis-responsive self-assembly strategy, and how the in situ-generated SPs are capable of interfering and can interfere with cellular functions. The incorporation of a nucleophilic organocatalyst ( CAT ) into living cells accelerates the intracellular conversion of hydrazide ( H ) and aldehyde-derived precursors ( A ) to hydrazone-based monomers ( HA 3 ) that locally self-assemble into SPs. Interestingly, the in situ-generated SPs possess ignorable effects on cell viability and proliferation but remarkably hinder cell migration. Furthermore, the presence of SPs is found to retard intracellular diffusion and alter the organization of the actin cytoskeleton, both of which are suggested to be responsible for the hindered cellular migration. In considering the vastly wide range of synthetic SPs, tremendous non-natural cellular functionalities can be obtained by in situ-synthesizing SPs.}, archive = {J_ANGEW}, author = {Hucheng Wang and Ya-Ting Zheng and Jiahao Zhang and Yuliang Gao and Jingjing Chen and Peiwen Cai and Junyou Wang and Jan H. van Esch and Xuhong Guo and Hui Li and Yiming Wang}, doi = {10.1002/anie.202500998}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500998}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of abiotic supramolecular polymers inside living cells via organocatalysis-mediated self-assembly}, volume = {64}, year = {2025}, }
• (2025). Nanopore confinement-driven synchronous enhancement of thermal and mechanical properties of phase change materials. ANGEW, 64(21), e202500957. (www)

  @article{ , abstract = {Phase change materials (PCM) need highly thermally conductive inorganic porous skeletons to encapsulate and shape to reduce their leakage and enhance their thermal conduction. With the pore size shrinking to nanoscale, the crystallization, kinematic and thermal transport behaviors of PCM would be significantly changed. This work experimentally corroborates an intriguing nanopore confinement space effect that synchronously enhances the thermal conductivity and Young's modulus of representative PCM once encapsulated in nanoporous aluminum oxide using nanometer resolution thermal and mechanical mapping technique. Molecular dynamic simulation further reveals that the shortened hydrogen bond length due to the nanopore confinement facilitates the heat conduction of PCM, which refreshes the routine understanding that smaller space leads to reduction in thermal and mechanical properties.}, archive = {J_ANGEW}, author = {Lin Qiu and Zhaoyi Wang and Zihan Liu and Haimo Li and Yanhui Feng}, doi = {10.1002/anie.202500957}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500957}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanopore confinement-driven synchronous enhancement of thermal and mechanical properties of phase change materials}, volume = {64}, year = {2025}, }
• (2025). Pathway-dependent control of chiral phases for higher performance and inverted circularly polarized luminescence. ANGEW, 64(21), e202500956. (www)

  @article{ , abstract = {Chiral luminescent materials have garnered increasing attention for their exceptional ability to emit circularly polarized luminescence (CPL) along with their excellent applications. Here, a cyclohexylidene scaffold was conceptualized as a chiral source for developing higher-performance CPL materials in terms of simultaneously enhanced quantum yields (PLQYs) and dissymmetry factor. It was found that the axially chiral scaffold attached with a cyanostilbene showed a pathway-dependent assembly route to form chiral luminescent liquid crystals and crystals upon fast and slow cooling, respectively. A significant enhancement of PLQYs (98.4%) and a dissymmetry factor ( g lum ) value (2.1 × 10 −2 ), and consequently, a high figure of merit (FM) of up to 0.02 was achieved in the chiral liquid crystal phase. Moreover, the liquid crystal and crystal phases showed the opposite CPL signals while maintaining the same circular dichroism signs. Through a thorough evaluation of UV absorption, CPL emission, wide-angle X-ray diffraction, and theoretical calculations, it was revealed that the reversal of the CPL sign was linked to distinct phases of excited state molecular packing. This research utilized a novel intrinsically axially chiral source to develop a pathway-dependent and higher-performance CPL materials.}, archive = {J_ANGEW}, author = {Sheng-Qi Qiu and Tian-Lin Yao and Yao Xiao and Gayathri Parthasarathy and Chao Xu and Yue Wu and Hong Xin and Guanghui Ouyang and Ming-Hua Liu and Zhen-Qiang Yu}, doi = {10.1002/anie.202500956}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500956}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pathway-dependent control of chiral phases for higher performance and inverted circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). An olefin radical based thiele's hydrocarbon derivative and macrocyclic tetraradical. ANGEW, 64(21), e202500943. (www)

  @article{ , abstract = {A persistent Thiele's hydrocarbon derivative, containing two five-membered dioxoborocyclic monoradical units bridged by a p -phenylene moiety, was generated. It exhibits an open-shell singlet ground state with a large singlet–triplet energy gap. A macrocyclic molecule composed of two units of the Thiele's hydrocarbon derivative was also prepared. The macrocyclic molecule possesses an open-shell singlet ground state but with considerable tetraradical character. The diradical and tetraradical compounds can be viewed as a zwitterionic species containing olefin radical cations. These newly formed compounds are stable in both the solid state and solution under an inert atmosphere for several days. They have been fully investigated by single-crystal X-ray diffraction, nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and UV-vis spectroscopy, and SQUID measurements, as well as theoretical calculations.}, archive = {J_ANGEW}, author = {Yu Zhao and Wenqing Wang and Li Zhang and Tao Wang and Liancheng He and Quanchun Sun and Yue Zhao and Xinping Wang}, doi = {10.1002/anie.202500943}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500943}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An olefin radical based thiele's hydrocarbon derivative and macrocyclic tetraradical}, volume = {64}, year = {2025}, }
• (2025). Fluorescence of helical molecular springs under high pressure. ANGEW, 64(21), e202500923. (www)

  @article{ , abstract = {Although the unique structure of helicenes resembles molecular springs, the effects of their extension–contraction cycles on their properties have rarely been explored. Here, we investigated the fluorescence of two π-extended [ n ]helicenes with different helical lengths n , named [7] and [9] , under high pressures in a diamond anvil cell. The experimental results showed that compound [9] , with a longer helical length, exhibited a more sensitive fluorescence response than [7] in both crystalline and solvated states upon compression. Theoretical calculations reveal that π–π overlapping at their helices in these molecular springs provides an additional contribution to their fluorescence properties under compression when the overlap becomes sufficiently strong. Our results provide insights into structure–property relationships of helical molecules under high-pressure conditions and verify the potential of helicenes as molecular springs for future applications in molecular machines.}, archive = {J_ANGEW}, author = {Jiaxu Liang and Cheng-Wei Ju and Zonghang Liu and Hailong Li and Aigerim Karina and Tobias Eklund and Wenhao Zheng and Katrin Amann-Winkel and Weizhao Cai and Manfred Wagner and Zijie Qiu and Tanja Weil and Klaus Müllen}, doi = {10.1002/anie.202500923}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorescence of helical molecular springs under high pressure}, volume = {64}, year = {2025}, }
• (2025). Anchor peptide-based immobilization strategy promote the applications of pickering emulsion system in natural products glycosylation. ANGEW, 64(21), e202500834. (www)

  @article{ , abstract = {Pickering emulsion systems serve as an advanced platform for efficient fine chemical production in biphasic enzymatic catalysis, though their applications are currently limited to a few commercial enzyme classes. Herein, we designed an anchor peptide-based immobilization strategy for Pickering emulsions to achieve efficient glycosylation of natural products by glycosyltransferases (GTs). Firstly, through enzyme mining, natural GTs were utilized to synthesize pharmaceutically important acacetin glucoside and galactoside. However, the best-performing enzymes, BacGT and BarGT-3, still showed low conversions for acacetin glucoside (<40%) and galactoside (<10%). Then, Spy chemistry was employed to cyclize these two GTs (Spy_BacGT and Spy_BarGT-3) for improved robustness, and a Pickering emulsion was formed with the free two Spy_GTs, using 20% 2-hexanone and 1% mesoporous silica nanoparticles (carriers of mesoporous, CM), achieving 70% and 66% conversions of acacetin glucoside and galactoside, respectively. Further immobilization of the cyclized GTs onto CM via the anchor peptide liquid chromatography peak I (LCI) (Spy_BacGT/BarGT-3_LCI@CM) further enabled the system to reach more than 90% conversions of acacetin glycosides, retaining 90% conversions after 6–8 cycles. Moreover, this strategy was applied to GTs exhibiting substrate selectivity, achieving efficient nonselective catalysis. This study provides a simple and efficient immobilization strategy to broaden the applications of the Pickering emulsion system in enzymatic glycosylation.}, archive = {J_ANGEW}, author = {Peng Zhang and Zhe Dong and Shuaiqi Meng and Zhongyu Li and Yu Ji and Ulrich Schwaneberg}, doi = {10.1002/anie.202500834}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500834}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anchor peptide-based immobilization strategy promote the applications of pickering emulsion system in natural products glycosylation}, volume = {64}, year = {2025}, }
• (2025). Machine learning-assisted exploration of chemical space of MOF-5 analogs for enhanced C2H6/C2H4 separation. ANGEW, 64(21), e202500783. (www)

  @article{ , abstract = {Adsorptive separation using C 2 H 6 -selective adsorbents can produce high-purity C 2 H 4 directly, making it an energy-efficient separation method with the potential to replace cryogenic distillation. Although many C 2 H 6 -selective MOFs have been reported, developing MOFs with both large C 2 H 6 adsorption capacity and high C 2 H 6 /C 2 H 4 selectivity remains challenging. Herein, we present a machine learning–assisted molecular simulation strategy to explore the C 2 H 6 /C 2 H 4 separation capability of pcu -MOFs isoreticular to MOF-5. The eXtreme gradient boosting (XGBoost) algorithm showed high accuracy in predicting the C 2 H 6 /C 2 H 4 selectivity and C 2 H 6 uptake, where Henry coefficient ratio ( S 0 ) and Henry coefficient of C 2 H 6 ( K (C 2 H 6 )) were identified as key factors. We further synthesized the top-performing MOF termed A-66 and experimentally verified its large C 2 H 6 adsorption capacity and excellent C 2 H 6 /C 2 H 4 separation performance. This work provides a valuable strategy for exploring the chemical space of MOF-5 analogs and identifying promising candidates for the efficient purification of C 2 H 4 from C 2 H 6 /C 2 H 4 mixtures.}, archive = {J_ANGEW}, author = {Ying Wang and Zhi-Jie Jiang and Weigang Lu and Dan Li}, doi = {10.1002/anie.202500783}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500783}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning-assisted exploration of chemical space of MOF-5 analogs for enhanced C2H6/C2H4 separation}, volume = {64}, year = {2025}, }
• (2025). Selective masking of active sites in zinc metal via galvanic replacement reaction for highly reversible ah-level zinc-i2 batteries. ANGEW, 64(21), e202500731. (www)

  @article{ , abstract = {Zinc metal anodes suffer from severe dendrite formation and corrosion due to active Zn sites. Here, an ultrathin, hydrophobic copper phosphate (CP) membrane is introduced that selectively masks active Zn sites with electrochemically inactive copper through a galvanic replacement reaction (Zn 0 + Cu 2+ = Cu 0 + Zn 2+ ). Copper is deliberately chosen for its higher redox potential (Cu 2+ /Cu 0 ; +0.34 V vs SHE), which effectively inhibits both the corrosion reaction (H + /H 2 ; 0 V vs SHE) and dendrite formation (Zn 2+ /Zn 0 ; −0.76 V vs SHE). In this way, the CP layer masks protrusions and grain boundaries on the zinc anode surface with inactive copper, blocking corrosion and dendritic growth, while its hydrophobic top layer reduces water activity at the interface. Benefiting from the deactivated anode surface, the resulting CP/Zn anode demonstrates exceptional stability, sustaining over 11,000 plating/stripping cycles at 10 mA cm −2 with an average Coulombic efficiency of 99.98 %. Moreover, a CP/Zn||I 2 full cell with an N/P ratio of 1.85 achieves an energy density of 187 Wh kg −1 electrodes , while a 1.2-Ah pouch cell validates its practical feasibility. This work highlights the importance of designing suitable surface chemistry to protect the Zn metal anode and indicates promising applications in other metal anodes.}, archive = {J_ANGEW}, author = {Yifan Fu and Junpeng Li and Mengqi Wu and Junjie Ba and Jin Zhang and Yisen Zhao and Yingjin Wei and Kangning Zhao and Yizhan Wang}, doi = {10.1002/anie.202500731}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500731}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective masking of active sites in zinc metal via galvanic replacement reaction for highly reversible ah-level zinc-i2 batteries}, volume = {64}, year = {2025}, }
• (2025). Charge tuning and anchor effect achieving stable high-voltage layered metal oxides for sodium-ion battery. ANGEW, 64(21), e202500715. (www)

  @article{ , abstract = {Layered metal oxides (LMOs) that can stably operate at high voltage are vital to developing high-energy sodium-ion batteries (SIBs). However, the irreversible oxygen redox reaction of LMOs at the high voltage region (i.e., >4.0 V vs. Na + /Na) will cause serious oxygen evolution and structural instability, and therefore sharp capacity fading. Herein, we report the charge tuning and anchor effect of La doping to enhance the cycling stability of layered NaNi 1/3 Fe 1/3 Mn 1/3 O 2 (NFM) under extreme conditions (e.g., high voltage and temperature). The La doping introduces additional negative charges to the oxygen ligands of transition metals (TM) and facilitates charge transfer, thereby reducing oxygen evolution at 4.1 V and enhancing the kinetics of the redox process. Moreover, the as-formed LaO 6 octahedra serve as stable anchors for the TM layers, preventing the formation of lattice nanocracks. As a result, the La-modified NFM exhibits a high capacity of 173.4 mAh g −1 at 0.1C (1C = 150 mA g −1 ) and capacity retention of 71.21% at 2.0–4.2 V after 500 cycles at 1C, which are higher than those of NFM. Additionally, the full cell achieves a high energy density of 438.78 Wh kg −1 (based on cathode mass), with a retention of 70.2% over 400 cycles, implying the great application potential of this concept.}, archive = {J_ANGEW}, author = {Jialin Kuang and Zhuoming Liu and Liang Fu and You Shi and Mengjie Zhang and Yan Wang and Ning Ding and Dan Sun and Yougen Tang and Haiyan Wang}, doi = {10.1002/anie.202500715}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500715}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Charge tuning and anchor effect achieving stable high-voltage layered metal oxides for sodium-ion battery}, volume = {64}, year = {2025}, }
• (2025). Inter-site distance effect in electrocatalysis. ANGEW, 64(21), e202500644. (www)

  @article{ , abstract = {The inter-site distance effect (ISDE) has gained significant attention in heterogeneous catalysis, challenging classical models that treat adjacent nonbonded sites as isolated. Recent studies demonstrate that these sites can exhibit long-range cooperative interactions, enhancing reaction efficiencies. Fully leveraging the ISDE to overcome limitations in site reactivity requires a multidisciplinary approach and advanced techniques. This review provides a comprehensive overview of ISDE in electrocatalysis, starting with strategies for synthesizing materials with tunable inter-site distances. It examines ISDE across various catalyst models, including monometallic and heteronuclear atomic sites, active sites within clusters, and the lattice of nanocatalysts, focusing on their electronic structures, spatial geometries, and synergistic interactions. Advanced characterization and computational methods are highlighted as essential for identifying inter-site structures and distances, providing a systematic framework for understanding ISDE's role in electrocatalysis. The review also proposes best practices for studying ISDE, addressing current challenges and offering future perspectives. These insights aim to inform the design of highly efficient catalysts, enhance the understanding of catalytic mechanisms, and contribute to the development of more efficient energy conversion technologies, providing a foundation for further research into optimizing electrocatalysts.}, archive = {J_ANGEW}, author = {Jiongcan Xiang and Pengfei Wang and Panpan Li and Min Zhou and Guihua Yu and Zhaoyu Jin}, doi = {10.1002/anie.202500644}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inter-site distance effect in electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Competition between one- and two-electron unimolecular reactions of late 3d-metal complexes [(Me3SiCH2)nM]–(M = fe, co, ni, and cu; n = 2–4). ANGEW, 64(21), e202500524. (www)

  @article{ , abstract = {Although organometallic complexes of the late 3d elements are known to undergo both one-and two-electron reactions, their relative propensities to do so remain poorly understood. To gain direct insight into the competition between these different pathways, we have analyzed the unimolecular gas-phase reactivity of a series of well-defined model complexes [(Me 3 SiCH 2 ) n M] − (M = Fe, Co, Ni, and Cu; n = 2–4). Applying a combination of tandem-mass spectrometry, quantum-chemical computations, and statistical rate-theory calculations, we find several different fragmentation reactions, among which the homolytic cleavage of metal-carbon bonds and radical dissociations are particularly prominent. In all cases, these one-electron reactions are entropically favored. For the ferrate and cobaltate complexes, they are also energetically preferred, which explains their predominance in the corresponding fragmentation experiments. For [(Me 3 SiCH 2 ) 4 Ni] − and, even more so, for [(Me 3 SiCH 2 ) 4 Cu] − , a concerted reductive elimination as a prototypical two-electron reaction is energetically more favorable and gains in importance. [(Me 3 SiCH 2 ) 3 Ni] − is special in that it has two nearly degenerate spin states, both of which react in different ways. A simple thermochemical analysis shows that the relative order of the first and second bond-dissociation energies is of key importance in controlling the competition between radical dissociations and concerted reductive eliminations.}, archive = {J_ANGEW}, author = {Torben Kühl and Lisa Hetzel and Christopher J. Stein and Konrad Koszinowski}, doi = {10.1002/anie.202500524}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Competition between one- and two-electron unimolecular reactions of late 3d-metal complexes [(Me3SiCH2)nM]–(M = fe, co, ni, and cu; n = 2–4)}, volume = {64}, year = {2025}, }
• (2025). Mechanism switch between radical-polar crossover and radical buffering. ANGEW, 64(21), e202500522. (www)

  @article{ , abstract = {Radical-polar crossover (RPC) is a classic concept that bridges one- and two-electron chemistry. It has been widely used in Cr-catalyzed carbonyl addition reactions to clarify the formation of alkyl chromium(III) intermediate and subsequent carbonyl insertion. Herein, we proposed an orthogonal bonding model, the radical buffering scenario, for Cr-catalyzed carbonyl alkylation. This radical bonding model features the radical dissociation from the alkyl chromium(III) complex followed by the Cr(II)-carbonyl-coupled radical addition to form the C─C bond. The mechanism switch between the radical and polar bonding models is affected by the radical stability, radical nucleophilicity, radical size, and the presence of an α-heteroatom or α–π bond. The collaborative computational and experimental studies have verified the reliability of the radical mechanism. More importantly, we demonstrated that this radical buffering scenario possesses a different stereoselectivity control model from that in the RPC scenario. A general enantioselectivity and diastereoselectivity control model derived from the multiple ligand-radical interactions is thus established for CrCl 2 /bisoxazoline-catalyzed asymmetric radical addition.}, archive = {J_ANGEW}, author = {Minghao Xu and Yan-Bo Li and Huamin Wang and Frank Glorius and Xiaotian Qi}, doi = {10.1002/anie.202500522}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500522}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanism switch between radical-polar crossover and radical buffering}, volume = {64}, year = {2025}, }
• (2025). Concurrent folding and fluorescent functionalization of single-chain nanoparticles via heterogeneous photochemistry. ANGEW, 64(21), e202500354. (www)

  @article{ , abstract = {The controlled folding of synthetic polymers, mimicking the complex behaviors of biomacromolecules, offers the potential to create sophisticated nanostructures with diverse functionalities. Of great significance is the integration of functionalization directly with chain folding, especially through the incorporation of artificial elements not found in nature, which allows unprecedented flexibility in materials design. However, this approach faces significant synthetic challenges, owing to the intricate integration of multiple chemical processes within a single chain. Here, a heterogeneous photochemistry strategy is presented to achieve single-chain polymer folding alongside concurrent fluorescent functionalization, inspired by the stepwise folding mechanism of green fluorescent protein. This method involves pre-folding amphiphilic heterograft random copolymers in water, which facilitates heterogeneous aggregation into distinct domains within single-particle nanostructures, including closely aggregated and molecularly dispersed regions. By employing spatial organization-dependent photochemical reactivity of cyanostilbene moieties, two concurrent processes are enabled: intrachain crosslinking via photodimerization in aggregated domains and fluorescent functionalization via photocyclization to form a green fluorophore in dispersed regions. Additionally, the incorporation of fluorescent dyes via intrachain excitation energy transfer allows for the modulation of emission properties, extending from green to red, and even including white light, making them promising candidates for bioimaging and related applications.}, archive = {J_ANGEW}, author = {Tianshu Ma and Bin Mu and Wei Tian}, doi = {10.1002/anie.202500354}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500354}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concurrent folding and fluorescent functionalization of single-chain nanoparticles via heterogeneous photochemistry}, volume = {64}, year = {2025}, }
• (2025). Modulating binding strength and acidity of benzene-derivative ligands enables efficient and hysteresis-free Perovskite/Silicon tandem solar cells. ANGEW, 64(21), e202500350. (www)

  @article{ , abstract = {Passivating defects at the wide-bandgap perovskite/C 60 interface without impeding interfacial charge transport can effectively enhance the efficiency of perovskite/silicon tandem solar cells (TSCs). Herein, we study the impact of benzene-derivative ligands with elaborately modulated binding strength and acidity on wide-bandgap perovskites for high-performance perovskite/silicon TSCs. Specifically, the acidity/alkalinity and binding strength are preliminarily tuned using different functional groups of -PO₃H₂, -COOH, and -NH₂, and further finely adjusted by altering the chain lengths between the benzene ring and the functional groups. The results show that strong binding is indispensable for effectively suppressing voltage loss. However, the commonly used benzylphosphonic acid (BPPA) for firm surface binding exhibits too strong acidity that can etch the perovskite surface, resulting in halide-vacancy defects and pronounced hysteresis. Increasing the side chain length of BPPA to (2-phenylethyl)phosphonic acid not only enables a suitable acid dissociation constant (p K a) to avoid acid-induced etching but also achieves robust anchoring to the perovskite surface with a parallel adsorption orientation, which reduces the charge transport barrier at the interface. These properties enable strong-adsorption surface termination (SAST) of the perovskite surface while preventing acid-induced etching. As a result, the SAST strategy achieves a remarkable efficiency of 32.13% (certified 31.72%) for hysteresis-free perovskite/silicon TSCs.}, archive = {J_ANGEW}, author = {Liu Yang and Shibo Wang and Ninggui Ma and Wei Shi and Zheng Fang and Yongbin Jin and Enlong Hou and Peng Xu and Fengxian Cao and Wenhao Li and Kun Gao and Yao Li and Dinxin Cao and Shaofei Yang and Cao Yu and Liqiang Xie and Xinbo Yang and Zhanhua Wei}, doi = {10.1002/anie.202500350}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating binding strength and acidity of benzene-derivative ligands enables efficient and hysteresis-free Perovskite/Silicon tandem solar cells}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic stereochemical editing for the concise syntheses of (25S)-Δ7-dafachronic acid, demissidine, and smilagenin. ANGEW, 64(21), e202500341. (www)

  @article{ , abstract = {Stereochemistry editing serves as an important tool to precisely adjust the desired stereochemical configuration of a molecule. In this study, enabled by photocatalytic stereochemical editing of tertiary C─H bonds of steroids, we have completed concise syntheses of (25 S )-Δ 7 -dafachronic acid, demissidine, and smilagenin. The feasibility of regioselectively editing tertiary stereocenters with either very weak α-hydroxyl C─H bonds (in the synthesis of dafachronic acid), α-amino C─H bonds (in the synthesis of demissidine), or with varying steric hindrance (in the synthesis of smilagenin) has been successfully demonstrated.}, archive = {J_ANGEW}, author = {Xiaotong Li and Zhaoguo Zhang and Jingjing Wu}, doi = {10.1002/anie.202500341}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500341}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic stereochemical editing for the concise syntheses of (25S)-Δ7-dafachronic acid, demissidine, and smilagenin}, volume = {64}, year = {2025}, }
• (2025). Rapid and in situ active sites regeneration for OER activity recovery and greatly prolonged water-splitting performance. ANGEW, 64(21), e202500303. (www)

  @article{ , abstract = {Inspired by the continuous regeneration of enzymes in living organisms that enables sustained long-term enzymatic reactions, we propose an active site regeneration strategy to rapidly and in situ recover the catalytic activity of oxygen evolution reaction (OER) for the electrode through switching anode solution, to substantially prolong the service life of the electrolytic cell. The OER activity of anodic NiFe(S)/NM catalyst synthesized by coating S-doped NiFe-LDH on nickel mesh (NM) exhibited excellent initial activity, then experienced gradual active site and activity losses due to the nanosheet detachment from NM after a long-term OER process. Attractively, such a damaged catalyst and its active sites can be effectively regenerated by an in situ redox reaction followed by electrochemical oxidation through switching the anode into the different solutions, resulting in the full recovery of the OER activity to its initial value. The recovered catalyst (R-NiFe(S)/NM) retains 90% of the initial activity and can be operated stably for over 80 h at 300 mA cm −2 even after four cycles of being damaged and recovered, and the established electrolyzer equipped with in situ recovered catalyst can be operated at the identical current density and almost the same cell voltage to that of the initial one.}, archive = {J_ANGEW}, author = {Qin Li and Wenshu Luo and Xiangzhi Cui and Jianlin Shi}, doi = {10.1002/anie.202500303}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500303}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid and in situ active sites regeneration for OER activity recovery and greatly prolonged water-splitting performance}, volume = {64}, year = {2025}, }
• (2025). Asymmetric synthesis of S(IV)-stereogenic sulfinimidate esters by sulfinamide activation. ANGEW, 64(21), e202500170. (www)

  @article{ , abstract = {Catalyst-controlled approaches for the synthesis of S-stereogenic compounds have propelled significant advancements in asymmetric synthetic chemistry. In contrast, control over S-heteroatom (e.g., O) bond formation to access sulfinimidate esters remains an underexplored area. Drawing inspiration from recent progress in electrophilic amide activation, herein, we present a sulfinamide activation strategy for the enantioselective synthesis of S-chiral sulfinimidate esters. This method involves the activation of racemic sulfinamides by sulfonyl chloride, yielding a reactive aza-sulfinyl mixed anhydride intermediate. Employing a naturally occurring cinchonidine catalyst, the process achieves excellent enantiocontrol in the subsequent formation of S─O bonds with alcohols involving a dynamic kinetic resolution (DKR) process, resulting in sulfinimidate esters with excellent enantioselectivity. The catalytically obtained enantioenriched sulfinimidate esters offer a versatile platform for the construction of S-stereogenic frameworks, including sulfilimines and sulfoximines, with promising applications in asymmetric synthesis and drug discovery.}, archive = {J_ANGEW}, author = {Qiang Xiong and Minghong Liao and Sha Zhao and Sitian Wu and Ya Hong and Yonggui Robin Chi and Xinglong Zhang and Xingxing Wu}, doi = {10.1002/anie.202500170}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500170}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric synthesis of S(IV)-stereogenic sulfinimidate esters by sulfinamide activation}, volume = {64}, year = {2025}, }
• (2025). Ferritin-inspired encapsulation and stabilization of gold nanoclusters for high-performance photothermal conversion. ANGEW, 64(21), e202500058. (www)

  @article{ , abstract = {Gold nanoclusters (AuNCs) are highly promising for applications in photothermal conversion due to their exceptional surface area and optical properties. However, their high surface energy often leads to aggregation, compromising stability and performance. To address this, we developed a ferritin-inspired covalent organic cage with a near-enclosed cavity to physically stabilize AuNCs. This superphane cage coordinates with Au 3 ⁺ ions, forming highly stable and uniform AuNCs upon reduction. The encapsulated AuNCs exhibit broad absorption (250–2500 nm) and achieve remarkable photothermal conversion efficiency of 92.8% under 808 nm laser irradiation. At low power densities (0.5 W/cm 2 ), temperatures reach 150 °C, and under one-sun illumination (1 kW/m 2 ), the solar-to-vapor generation efficiency reaches 95.1%, with a water evaporation rate of 2.35 kg m −2 h −1 . Even after 20 seawater desalination cycles, the system maintains a stable evaporation rate of 2.24 kg m −2 h −1 , demonstrating excellent salt tolerance and durability. This ferritin-inspired strategy offers a robust platform for enhancing the stability and performance of AuNCs, advancing sustainable energy and water purification technologies.}, archive = {J_ANGEW}, author = {Yi Zhang and Juan Zhou and Ke Luo and Wei Zhou and Fei Wang and Jialian Li and Qing He}, doi = {10.1002/anie.202500058}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500058}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ferritin-inspired encapsulation and stabilization of gold nanoclusters for high-performance photothermal conversion}, volume = {64}, year = {2025}, }
• (2025). Amphipathic antimicrobial peptides illuminate a reciprocal relationship between self-assembly and cytolytic activity. ANGEW, 64(21), e202500040. (www)

  @article{ , abstract = {Amphipathic character, encoded within the polar sequence patterns of antimicrobial peptides, is a critical structural feature that influences membrane disruptive behavior. Similarly, polar sequence patterns induce self-assembly of amphipathic peptides, which results in the formation of ordered supramolecular structures. The relationship between self-assembly and membrane activity remains an open question of relevance for the development of effective antimicrobial peptides. Here, we report the structural investigation of a class of lytic peptides that self-assemble into filamentous nanomaterials. CryoEM analysis was employed to determine the structure of one of the filaments, which revealed that the peptides are self-assembled into a bilayer nanotube, in which the interaction between layers of amphipathic α -helices was mediated through hydrophobic interactions. The relative stability of the filament peptide assemblies depended on the influence of sequence modifications on the helical conformation. Antimicrobial assays indicated that cytolytic activity was associated with dynamic disassociation of the filamentous assemblies under the assay conditions. Structural modifications of the peptides that stabilized the filaments abrogated lytic activity. These results illuminate a reciprocal relationship between self-assembly and antimicrobial activity in this class of amphipathic peptides and that reversible assembly was critical for the observation of biological activity.}, archive = {J_ANGEW}, author = {Breana Laguera and Martina M. Golden and Fengbin Wang and Ordy Gnewou and Abraham Tuachi and Edward H. Egelman and William M. Wuest and Vincent P. Conticello}, doi = {10.1002/anie.202500040}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202500040}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amphipathic antimicrobial peptides illuminate a reciprocal relationship between self-assembly and cytolytic activity}, volume = {64}, year = {2025}, }
• (2025). Realization of tunable ferroelectricity in perovskite crystals for multidirectional self-driven photodetection. ANGEW, 64(21), e202425653. (www)

  @article{ , abstract = {Halide perovskite ferroelectrics endowed with a distinctive spontaneous polarization effect have been regarded as prospective electroactive materials and are prevalently utilized in solar cells, photoelectric detection, and other domains. Among them, multipolar-axis ferroelectrics featuring multiple equivalent polarization directions are particularly desirable for diverse areas of applications. Nevertheless, the design and regulation of multipolar axis perovskite ferroelectrics remains a significant challenge. Here, guided by the strategy of layer regulation, we successfully designed and regulated a series of 2D homologous perovskites OA 2 Cs n -1 Pb n Br 3 n +1 (OA = n -octylammonium, n = 1–3). Notably, OA 2 Cs n -1 Pb n Br 3 n +1 exhibits layer-dependent ferroelectricity: OA 2 PbBr 4 exhibits non-ferroelectricity, OA 2 CsPb 2 Br 7 displays uniaxial ferroelectricity, while OA 2 Cs 2 Pb 3 Br 10 has multiaxial ferroelectricity. Moreover, the devices fabricated based on OA 2 Cs 2 Pb 3 Br 10 achieve high-performance self-driven photodetection in multiple directions. This precise layer-regulation strategy offers an efficient approach to obtaining and regulating multipolar-axis perovskite ferroelectrics, presenting the potential for next-generation optoelectronic devices.}, archive = {J_ANGEW}, author = {Zhijin Xu and Jing Liang and Tianqi Chen and Xin Dong and Haotian Wen and Jie Qin and Minmin Wang and Junhua Luo and Lina Li}, doi = {10.1002/anie.202425653}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425653}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Realization of tunable ferroelectricity in perovskite crystals for multidirectional self-driven photodetection}, volume = {64}, year = {2025}, }
• (2025). Synthesis of linear and cyclic poly(allenamer)s by powerful Cyclic–Alkyl–Amino–Carbene (CAAC) ruthenium catalysts and facile post-modification. ANGEW, 64(21), e202425648. (www)

  @article{ , abstract = {Cyclic polymers are very attractive due to their unique properties; however, so far, they have simple and less reactive backbone structures due to synthetic limitations, restricting their further post-modification. Notably, allenes present a potentially useful platform in polymer chemistry due to their well-established toolbox in organic chemistry. Nevertheless, the biggest challenge remains in synthesizing poly(allenamer)s with high allene contents or polymerization efficiency, as well as synthesizing different types of cyclic poly(allenamer)s. Herein, we synthesized linear and cyclic poly(allenamer)s via ring-opening metathesis polymerization (ROMP) and ring-expansion metathesis polymerization (REMP), employing highly efficient cyclic–alkyl–amino–carbene (CAAC) ruthenium catalysts. Mechanistic studies suggested CAAC ligands enhanced stability of propagating Ru vinylidene, enabling various linear and cyclic poly(allenamer)s with turnover number up to 1360 and molecular weight reaching 549 kDa. Their cyclic architecture was thoroughly characterized by multiangle light scattering size-exclusion chromatography (MALS SEC) with viscometer. Moreover, controlled ROMP of a highly reactive α-substituted cyclic allene was achieved using third-generation Grubbs' catalyst. Finally, we demonstrated highly efficient and selective post-modifications on poly(allenamer)s with primary and secondary alcohols. This broadens the scope of cyclic polymers with improved efficiency and structural control, affording a practical platform for diverse macromolecules.}, archive = {J_ANGEW}, author = {Yongkang Yang and Minjae Jang and Hoonseok Kang and Solhye Choe and Eunsung Lee and Tae-Lim Choi}, doi = {10.1002/anie.202425648}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425648}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of linear and cyclic poly(allenamer)s by powerful Cyclic–Alkyl–Amino–Carbene (CAAC) ruthenium catalysts and facile post-modification}, volume = {64}, year = {2025}, }
• (2025). Weak attractive noncovalent interactions in metal-catalyzed asymmetric hydrogenation. ANGEW, 64(21), e202425589. (www)

  @article{ , abstract = {Weak attractive noncovalent interactions, specifically CH/π⋯HC/π and CH⋯O/N contacts, between catalysts and substrates have recently gained renewed attention in asymmetric hydrogenations, despite their historical underappreciation due to challenges in detection. Emerging evidence underscores the significant role of these interactions in improving reactivity and/or enantioselectivity, particularly in sustainable catalytic systems that utilize Earth-abundant transition metals. This minireview summarizes advancements in asymmetric hydrogenations catalyzed by both noble and Earth-abundant metal complexes under an H₂ atmosphere, with a focus on the roles of CH/π⋯HC/π and CH⋯O/N noncovalent interactions in improving reactivity and/or enantioselectivity. Taking into account the weak attractive character of these noncovalent interactions, it is expected to help the design of novel chiral transition metal catalysts and develop more efficient asymmetric hydrogenation systems for the large-scale synthesis of diverse chiral compounds.}, archive = {J_ANGEW}, author = {Jianzhong Chen and Hanlin Wei and Ilya D. Gridnev and Wanbin Zhang}, doi = {10.1002/anie.202425589}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Weak attractive noncovalent interactions in metal-catalyzed asymmetric hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Double-chain copolymer network via in situ polymerization enables high-stability and lead-safe perovskite solar cells. ANGEW, 64(21), e202425578. (www)

  @article{ , abstract = {Lead halide perovskite solar cells (PSCs) have made significant progress due to their low cost and high efficiency. However, the long-term stability and lead toxicity of PSCs remain a huge challenge for further commercialization. Herein, we designed a multifunctional additive, poly(amide ester) (PAE), with photosensitive properties to overcome these difficulties. A unique double-chain copolymer network can be constructed via in situ polymerization induced by ultraviolet (UV) light. The multiple active sites in the polymer chains can passivate various defects and enhance charge transfer. Meanwhile, the vast network provides an effective defense for perovskite to stabilize the internal structure and resist harsh external environments, thus delaying the degradation of devices and maximizing the suppression of toxic lead leakage. Remarkably, the devices protected by the network achieved a champion power conversion efficiency (PCE) of 26.20% (certified as 25.69%), the unencapsulated devices suppressed 80% of lead leakage, and the encapsulated devices maintained 93% of the initial PCE after 1000 h in a humid and thermal environment (65 °C and 85% RH).}, archive = {J_ANGEW}, author = {Jiaxin Ma and Shengnan Fan and Cong Shao and Lizhe Wang and Yuan Dong and Guosheng Niu and Zongxiu Nie and Shiyong Yang and Jizheng Wang and Haixia Yang}, doi = {10.1002/anie.202425578}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Double-chain copolymer network via in situ polymerization enables high-stability and lead-safe perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Facile fabrication of robust supraparticles for spatially orthogonal cascade catalysis. ANGEW, 64(21), e202425342. (www)

  @article{ , abstract = {Macroscopically sized supraparticles (SPs) are emerging as cutting-edge materials for industrial applications because of their unique properties unachievable for their nano-building blocks, but their effective methods are lacking. Here, a conceptually novel strategy is developed to assemble binary or ternary nanoparticles (NPs) within compartments of droplets through electrostatic interactions, making it possible to facilely fabricate millimeter-sized multicomponent ionic supraparticles (ISPs). The assembled ISPs possess unexpectedly high mechanical strength (50 N per bead), being amenable to practical applications. The key factors governing the assembly behavior of nano-building blocks within water droplet compartments are identified through regulating the size and charge density of NPs or ionic strength, providing key insights into the multileveled assembly of NPs beyond the conventional assembly. The strategy is demonstrated to be versatile since a library of tailor-made ISPs containing multicomponent, diversely shaped, and differently sized NPs can be facilely fabricated. As proof of this concept, it is showcased that this method enables the preparation of spatially orthogonal cascade catalysts by co-assembling acidic, basic, and metal sites in single millimeter-scaled particles. The catalysts exhibit significantly enhanced catalytic efficiency in a one-pot cascade synthesis of α -alkylated nitriles and high operational stability (200 h) in industrially preferred fixed-bed reactors.}, archive = {J_ANGEW}, author = {Nan Xue and Shengjie Li and Hengquan Yang}, doi = {10.1002/anie.202425342}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425342}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facile fabrication of robust supraparticles for spatially orthogonal cascade catalysis}, volume = {64}, year = {2025}, }
• (2025). Combining the active site construction and microenvironment regulation via a bio-inspired strategy boosts CO2 electroreduction under ampere-level current densities. ANGEW, 64(21), e202425325. (www)

  @article{ , abstract = {Electrochemical reduction of CO 2 reaction (CO 2 RR) is recognized as a complicated process involving multiple steps on the gas – electrode-solution interface. Hence, it is equally important to construct highly efficient active sites and regulate favorable microenvironments around the reaction interface. Herein, we propose a bio-inspired strategy to address both issues simultaneously in one catalytic system. We first evaporate isolated Au sites on the surface of the Cu layer to tune the intrinsic activity of the Cu catalyst, then fix hexanethiol (HEX) molecules onto the Au sites through Au─S bonds to regulate reaction microenvironments (CuAu-HEX). Specifically, those Au/Cu bimetallic active sites can decrease the energy barriers for the C─C coupling procedure and accelerate the generation of multicarbon products. More importantly, those stable and nondense HEX molecules on Au sites can ensure long-term hydrophobicity and high local concentration of CO 2 around active sites, rather than block the channels for reactant transfer. Consequently, this unique structure is favorable for the pathways toward multicarbon products, generating >70% Faradaic efficiencies (FE) for multicarbon products even at 1 A cm −2 . Intriguingly, this modification layer is very similar to animal hair follicles, which might present a new strategy to regulate the interfacial environments in various electrocatalytic reactions.}, archive = {J_ANGEW}, author = {Huizhu Cai and Hengpan Yang and Deliang Li and Sizhen He and Xue Zhang and Qi Hu and Chuanxin He}, doi = {10.1002/anie.202425325}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425325}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Combining the active site construction and microenvironment regulation via a bio-inspired strategy boosts CO2 electroreduction under ampere-level current densities}, volume = {64}, year = {2025}, }
• (2025). Identifying spatially segregated ir sites within ZSM-5 for enhanced redox cycle in NOx reduction by CO. ANGEW, 64(21), e202425312. (www)

  @article{ , abstract = {Developing high-performance Ir-based catalysts for selective catalytic reduction of NO x by CO (CO-SCR) under low temperatures remains challenging. This study presents an Ir-based catalyst encapsulated in Zeolite Socony Mobil-5 (Ir@ZSM-5), with Ir species partially confined in micropores (Ir δ+ ) and partially aggregated on the surface (Ir 0 ), achieving ∼88% NO x conversion at 230 ° C in the presence of 5% O 2 and 100 ppm SO 2 . The confined Ir δ+ species exhibit enhanced stability and oxidation states, whereas surface-aggregated Ir 0 species, with weaker oxygen coordination, remain in a metallic state. The dynamic equilibrium between Ir δ+ and Ir 0 significantly improves the balance of CO oxidation and NO reduction. O 2 promotes the oxidation of Ir 0 to Ir δ+ , whereas SO 2 facilitates the reverse, forming a reversible cycle that sustains catalytic efficiency. This work underscores the strategic interplay of Ir valence states and highlights a pathway for designing stable, high-performance Ir-based catalysts tailored for CO-SCR under complex reaction conditions.}, archive = {J_ANGEW}, author = {Wanrong Chen and Yixi Wang and Wenqing Xu and Chaoqun Li and Yang Yang and Tingyu Zhu}, doi = {10.1002/anie.202425312}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identifying spatially segregated ir sites within ZSM-5 for enhanced redox cycle in NOx reduction by CO}, volume = {64}, year = {2025}, }
• (2025). Radical chemistry of tetrazenes: Access to polymers with pristine tetrazenyl chain ends and depolymerization applications. ANGEW, 64(21), e202425279. (www)

  @article{ , abstract = {We report the first radical reaction of tetrazenes— i.e., functions with four consecutive nitrogen atoms with a linear N–N═N–N chain—that retains the characteristic 4N pattern. Selective hydrogen atom transfer (HAT) in the α-position of the 4N chain enables the free radical polymerization of various polar and nonpolar monomers. The tetrazene units play a dual role. Its decomposition generates aminyl radicals that can undergo HAT with another tetrazene molecule and lead to initiating C-centered radicals. Contrary to what was previously thought the aminyl radicals never add to the monomers. The polymers obtained feature tetrazene chain ends, which can be harnessed as macro-initiators to further grow the polymer chains. Heating of the former above the ceiling temperature leads to cleavage of the tetrazene function, which enables depolymerization by unzipping of polymethyl methacrylate (PMMA) and polystyrene (PS).}, archive = {J_ANGEW}, author = {Laetitia Bourgeois and Ahmad Hammoud and Lucas Chalouni and Anne Baudouin and Emmanuel Chefdeville and Lhoussain Khrouz and Anne Renault and Jennifer Lesage de la Haye and Jean Raynaud and Chaza Darwich and Emmanuel Lacôte}, doi = {10.1002/anie.202425279}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425279}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radical chemistry of tetrazenes: Access to polymers with pristine tetrazenyl chain ends and depolymerization applications}, volume = {64}, year = {2025}, }
• (2025). Accelerated destruction of passive film and microbial corrosion of 316 l stainless steel via extracellular electron transfer. ANGEW, 64(21), e202425220. (www)

  @article{ , abstract = {The dense passive film on 316 L stainless steel is the key in its corrosion resistance. Its interactions with an electroactive biofilm are critical in deciphering microbial corrosion. Herein, an in-depth investigation using genetic manipulations and addition of an exogenous electron mediator found that extracellular electron transfer (EET) mediated by the electroactive S. oneidensis biofilm grown aerobically accelerated the destruction of the microstructure and weakened the passive film. The changes in surface properties accelerated the electrochemical reactions and increased pitting corrosion. The redox state on the surface also changed due to the activity of the electroactive biofilm. A synergistic EET corrosion mechanism, including both direct and mediated electron transfer with passive film destruction was proposed to illustrate the corrosion caused by electroactive S. oneidensis . The techniques used in this work provide a systematic approach to probe EET impact on microbial corrosion by electroactive biofilms with electron transfer across the biotic-abiotic interfaces.}, archive = {J_ANGEW}, author = {Zhong Li and Jie Wang and Feng Li and Zhengtao Li and Enze Zhou and Yongqiang Fan and Hao Song and Zhaodong Xu and Tingyue Gu and Fuhui Wang and Dake Xu}, doi = {10.1002/anie.202425220}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425220}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerated destruction of passive film and microbial corrosion of 316 l stainless steel via extracellular electron transfer}, volume = {64}, year = {2025}, }
• (2025). Molecule differentiation encoding microscopy to dissect dense biomolecules in cellular nanoenvironments below spatial resolution. ANGEW, 64(21), e202425136. (www)

  @article{ , abstract = {Cellular biomolecules may exhibit dense distribution and organization at the nanoscale to govern vital biological processes. However, it remains a common challenge to digitize the spatially dense biomolecules under the spatial resolution of microscopies. Here, a proof-of-principle method, molecule differentiation encoding microscopy by orthogonal tandem repeat DNA identifiers is reported, to resolve the copy numbers of dense biomolecules in cellular nanoenvironments. The method encodes each copy of the same biomolecules into different types of DNA barcodes based on stochastic multiplexed reactions. It can transform the overlap of the same spectrum into the overlap of different spectra. Furthermore, an algorithm is developed to automatically quantitate overlapping spots and individual spots. Using this method, RNAs in the cytoplasm, DNA epigenetic modifications in the cell nucleus, and glycans and glycoRNAs on the cell surface are dissected, respectively. It is found that all these biomolecules present dense distribution with diverse degrees in crowded cellular nanoenvironments. Especially, an average 17% copies of U1 glycoRNA of single cells are gathered in various nano environments on the cell surface. The strategy provides a powerful tool for digitally quantitative visualization of dense biomolecules below the spatial resolution of microscopies and can provide insights into underlying functions and mechanisms of the dense distribution information.}, archive = {J_ANGEW}, author = {Siyue Fan and Xinyin Li and Huan Liu and Mengying Ye and Yan He and Wenhao Fu and Feng Chen and Yongxi Zhao}, doi = {10.1002/anie.202425136}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202425136}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecule differentiation encoding microscopy to dissect dense biomolecules in cellular nanoenvironments below spatial resolution}, volume = {64}, year = {2025}, }
• (2025). Halogen bonding as a tool to control morphology and charge transport in organic semiconductors. ANGEW, 64(21), e202424979. (www)

  @article{ , abstract = {The solid-state structure and morphology of organic semiconductors (OSCs) are critical in determining the performance of organic electronic devices, as they directly influence charge carrier mobility. Improved molecular packing and ordering are key to achieving better device performance. While halogen bonding (XB) has been extensively used in supramolecular crystal engineering, its potential for organic electronics remains largely untapped. Here, we show that strong and directional XB can significantly enhance the morphology and optoelectronic properties of a pyridine-substituted naphthalene diimide (NDI) derivative. By employing various XB donors with differing interaction strengths and comparing them to a nonbonding reference compound, we achieve a two-orders-of-magnitude improvement in field-effect mobility and I ON - I OFF ratio. Furthermore, the geometric substitution pattern of the XB donors is found to strongly influence molecular packing, crystalline domain formation, and, ultimately, device performance.}, archive = {J_ANGEW}, author = {Tero-Petri Ruoko and Marc-Antoine Stoeckel and Rakesh Puttreddy and Chi-Yuan Yang and Silan Zhang and Ziang Wu and Nuno R. Candeias and Paolo Samorì and Han Young Woo and Simone Fabiano and Arri Priimagi}, doi = {10.1002/anie.202424979}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424979}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogen bonding as a tool to control morphology and charge transport in organic semiconductors}, volume = {64}, year = {2025}, }
• (2025). Facile access to piezoelectric polyamides by polyamidation of carboxylic acids and ynamides for potent tumor immunotherapy. ANGEW, 64(21), e202424923. (www)

  @article{ , abstract = {Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring-opening polymerization of special lactams. However, developing a green polymerization approach for the facile synthesis of piezoelectric polyamides is highly desirable but also challenging. Here, a simple polyamidation of carboxylic acids and ynamides is successfully established to synthesize versatile piezoelectric polyamides. This polymerization also possesses the merits of 100% atom economy, no waste generation, and additive-free as well as catalyst-free system. A range of polyamides are synthesized in moderate to good yields with satisfactory molecular weights. Importantly, piezoelectric polyamides containing tetraphenylethene (P 1e/2b ) can generate a bundant reactive oxygen species under ultrasound (US) exposure, thereby eliciting robust immunogenic cell death induction for augmented piezoelectric immunotherapy. Furthermore, P 1e/2b exhibits distinctive aggregation-induced emission property that allows fluorescence imaging. In vivo evaluation using a bilateral tumor-bearing mouse model manifested that P 1e/2b administration reinforced systemic immunity and triggered immune memory under US exposure, thereby leading to primary tumor eradication and distant tumor suppression. Therefore, this work represents a transition-metal-free and waste-free polymerization paradigm for the construction of piezoelectric polyamides, providing a distinct strategy to designing new piezoelectric polymers for effective tumor immunotherapy.}, archive = {J_ANGEW}, author = {Xingguang Li and Ruiqi Yan and Mei Tan and Ryan T. K. Kwok and Jianwei Sun and Huijing Xiang and Xiang Ma and Jacky W. Y. Lam and Ben Zhong Tang}, doi = {10.1002/anie.202424923}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facile access to piezoelectric polyamides by polyamidation of carboxylic acids and ynamides for potent tumor immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Regiochemistry and side-chain engineering enable efficient N-type mixed conducting polymers. ANGEW, 64(21), e202424820. (www)

  @article{ , abstract = {Developing high-performance n-type organic mixed ionic-electronic conducting (OMIEC) polymers with simple structural motifs is still challenging. We show that high-performance, low-threshold-voltage n-type OMIEC polymers can be achieved using a simple diketopyrrolopyrrole unit flanked by thiazole groups, which is functionalized with glycolated side chains. Interestingly, the regiospecific sp 2 -N position in the repeating unit's thiazole governs the polymer chains' solvation and molecular packing. This specific backbone chemistry enhances conjugation efficiency, reduces trap density, and improves electrochemical doping efficiency. Moreover, systematic variation of glycolated side-chain lengths induces a sequential shift in molecular orientation—from edge-on through bimodal to face-on preferential alignment. This structural evolution achieves optimized ionic-electronic transport balance, resulting in exceptional device metrics: a geometrically normalized transconductance of 31.9 S cm −1 , a figure-of-merit µC * of 96.3 F cm −1 V −1 s −1 , and a threshold voltage of 0.31 V, positioning these materials among the highest-performing n-type OMIECs. An organic complementary inverter made from the optimized n-type OMIEC polymer and a reported p-type polymer exhibits a voltage gain of 198 V V −1 , effectively amplifying the ECG signal and enhancing signal quality. This work establishes structure-property guidelines for designing bioelectronic n-type OMIECs.}, archive = {J_ANGEW}, author = {Mingyu Ma and Linlong Zhang and Minhu Huang and Yazhuo Kuang and Hangyang Li and Huanzhou Yang and Tangqing Yao and Gang Ye and Shuyan Shao and Myung-Han Yoon and Jian Liu}, doi = {10.1002/anie.202424820}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424820}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regiochemistry and side-chain engineering enable efficient N-type mixed conducting polymers}, volume = {64}, year = {2025}, }
• (2025). Double sb-N coordination enables record-high birefringence in UV-transparent crystals. ANGEW, 64(21), e202424756. (www)

  @article{ , abstract = {Achieving high birefringence in ultraviolet (UV)-transparent crystals has remained a significant challenge due to the absence of systematic design methodologies. Herein, we present a novel organic–inorganic coordination strategy that combines π-conjugated organic ligands ([C 12 H 8 N 2 ]) with inorganic Sb-based polyhedra featuring stereochemically active lone pairs. This approach facilitates the formation of the first coplanar double Sb-N coordination framework, enabling the synthesis of two new birefringent hybrid crystals: (C 12 H 8 N 2 )SbF 2 (H 2 PO 3 ) (PNSP) and (C 12 H 8 N 2 )SbF 3 (PNSF). Notably, PNSF demonstrates an unprecedented birefringence of 0.79 at 546 nm, exceeding all known UV-transparent birefringent materials to date. These results not only expand the performance limits of birefringent hybrid crystals but also emphasize the pivotal role of stereochemically induced anisotropy in manipulating optical properties. Our study establishes a solid foundation for the rational design of next-generation optical materials, offering significant advancements for applications in cutting-edge photonic technologies, including UV polarizers and optical modulators.}, archive = {J_ANGEW}, author = {Pu Zhang and Xuehua Dong and Ling Huang and Zhien Lin and Yuqiao Zhou and Guohong Zou}, doi = {10.1002/anie.202424756}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424756}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Double sb-N coordination enables record-high birefringence in UV-transparent crystals}, volume = {64}, year = {2025}, }
• (2025). Iridium(III) carbene complexes featuring either metal-to-ligand charge transfer (MLCT) or through-space charge transfer (TSCT) blue luminescence. ANGEW, 64(21), e202424694. (www)

  @article{ , abstract = {Through-space charge transfer (TSCT), rather than the commonly postulated metal-to-ligand charge transfer (MLCT) process, was proposed in getting the lowest lying excited state of newly designed Ir(III) blue phosphors. Accordingly, two benzo[ d ]imidazolylidene pro-chelates, L12H 2 + and L13H 2 + , one with two cyano groups at the peri -benzo and N -aryl pendent and the other with its peri -cyano group being replaced with methyl substituent, were employed in syntheses of Ir(III) complexes f -ct12b , c and f -ct13b , c . Notably, complexes f -ct12b , c exhibited the traditional MLCT process, while f -ct13b,c were dominated by the TSCT transition, resulting in a smaller S 1 –T 1 energy gap Δ E ST . Next, it prompted us to explore whether their long-lived emission originated from phosphorescence or thermally activated delayed fluorescence (TADF). Although temperature-dependent emission studies favor TADF, the unresolved concerns are still discussed in depth. For application, OLED with the TSCT-based dopant f -ct13b delivered a maximum external quantum efficiency (EQE) of 22.2% and a max. luminance of 10 000 cd m ‒2 , together with CIE xy of (0.155, 0.120). Moreover, the hyper-OLED with f -ct13c sensitizer and v -DABNA terminal emitter exhibited a max. EQE of 28.2% and CIE xy of (0.123, 0.129), demonstrating a new approach in developing efficient Ir(III) blue phosphors.}, archive = {J_ANGEW}, author = {Jie Yan and Yixin Wu and Manli Huang and Lin Cheng and Yi Pan and Chi-Chi Wu and Chia-Hsun Yeh and Jian-Liang Li and Yan-Ding Lin and Yun Chi and Chuluo Yang and Pi-Tai Chou and Kai Chung Lau}, doi = {10.1002/anie.202424694}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424694}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iridium(III) carbene complexes featuring either metal-to-ligand charge transfer (MLCT) or through-space charge transfer (TSCT) blue luminescence}, volume = {64}, year = {2025}, }
• (2025). Deciphering the impact of polysulfide solvation structure on electrical double layer chemistry in Sodium–Sulfur batteries. ANGEW, 64(21), e202424547. (www)

  @article{ , abstract = {Room-temperature sodium–sulfur (RT Na–S) batteries are garnering attention for large-scale energy storage. However, their practical application is hindered by challenges, such as the shuttle effect of sodium polysulfides (NaPS) and dendrite growth. The high solubility of NaPS in the electrolyte is particularly problematic. It disrupts electron transfer and obstructs mass transport in the electrical double layer (EDL) region. The EDL plays a pivotal role in governing the interfacial chemistry between the electrode and electrolyte, significantly impacting the overall electrochemical performance. Through simulations and experimental screening of various solvents, including 1,2-dimethoxyethane (DME), tetrahydrofuran (THF), and tetrahydropyran (THP), along with ethyl 1,1,2,2-tetrafluoroethyl ether (ETFE) as a diluent, the relationship between NaPS solvation structure and EDL chemistry has been elucidated. Our findings reveal that THP-based localized high-concentration electrolyte (LHCE) not only reduces the solubility of NaPS by altering its solvation structure but also promotes the formation of a stable inorganic solid-electrolyte interphase (SEI) and improves compatibility with sodium metal. Consequently, Na–S batteries with LHCE-THP/ETFE exhibit long-term stability over 500 cycles at 1C rate with a capacity decay rate of only 0.07% per cycle. This study provides a methodology for designing electrolytes based on molecular structure, polysulfide solvation properties, and EDL interfacial chemistry.}, archive = {J_ANGEW}, author = {Weiqi Yao and Min-Hao Pai and Arumugam Manthiram}, doi = {10.1002/anie.202424547}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424547}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering the impact of polysulfide solvation structure on electrical double layer chemistry in Sodium–Sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Degradation of glyphosate to benign N-formyl glycine using MOF-808 nanocrystals. ANGEW, 64(21), e202424540. (www)

  @article{ , abstract = {Glyphosate ( N -phosphonomethyl glycine, GPh) is an industrial herbicide used worldwide in modern agricultural practices. With the growing concerns regarding cumulative environmental and health effects, pathways for catalytic GPh degradation to benign products are becoming a pressing societal need. This report demonstrates that Zr-based metal–organic framework (MOF-808) with different crystal sizes and designed defect sites can be employed as an efficient heterogeneous catalyst for the complete degradation of GPh at room temperature. Importantly, the degradation mechanism produces N -formyl glycine and hydroxymethyl-phosphonate, which are largely innocuous chemicals, especially when compared to more common GPh degradation products. Nanocrystalline MOF-808 (nMOF-808) exhibits enhanced reactivity than larger MOF-808 crystals, attributed to the higher coordination of hydroxyl and water molecules to the secondary building units (SBU) as determined using a range of X-ray absorption spectroscopy (XAS) techniques. These studies indicate that the crystal size-dependency in GPh degradation is related to structural modifications on coordinative unsaturated Zr site that promote the fast exchange of weakly bonded ligands. Taken together, this study demonstrates that GPh degradation can be optimized through ligand field tuning in MOFs, which can help improve overall reactivity while also pushing the reaction toward desirable, nontoxic products.}, archive = {J_ANGEW}, author = {Jhair A. Peña Prada and Tatiana A. Huertas Navarro and Stephanie L. Chua and Alejandro M. Granados and Chih-Wen Pao and Alejandro M. Fracaroli and Nicholas M. Bedford}, doi = {10.1002/anie.202424540}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424540}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Degradation of glyphosate to benign N-formyl glycine using MOF-808 nanocrystals}, volume = {64}, year = {2025}, }
• (2025). Indirect anti-markovnikov hydrofunctionalization of terminal alkenes via an alkenyl thianthrenium intermediate. ANGEW, 64(21), e202424422. (www)

  @article{ , abstract = {The anti-Markovnikov hydrofunctionalization of terminal, unactivated olefins is an evergreen synthetic challenge in organic chemistry. Several direct and indirect anti-Markovnikov methods have been developed, ranging from the classical hydroboration/oxidation protocol to state-of-the-art photoredox catalytic, transition-metal-complex-catalyzed, and enzymatic procedures. Despite the ever-expanding suite of synthetic capabilities, these methods still have limited generality in their substrate scope, especially with nucleophiles. Herein, we show that terminal, unactivated olefins can be transformed into anti-Markovnikov products via an alkenyl thianthrenium intermediate that undergoes sequential hydride and nucleophile addition. The strategic advantage of this method lies in the ability to utilize a diverse array of oxidatively sensitive nucleophiles as reaction partners. This is accomplished through a mechanistically distinct, two-stage dication pool anti-Markovnikov approach, where separate oxidative olefin activation by thianthrenation is followed by the selective generation of a reactive alkyl thianthrenium salt.}, archive = {J_ANGEW}, author = {Bence Sóvári and Péter Angyal and István J. Babcsányi and András M. Kotschy and Ádám Dudás and Gábor Turczel and Szilárd Varga and Tibor Soós}, doi = {10.1002/anie.202424422}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424422}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Indirect anti-markovnikov hydrofunctionalization of terminal alkenes via an alkenyl thianthrenium intermediate}, volume = {64}, year = {2025}, }
• (2025). Hydrogen bonding interaction enabled asymmetric C─H acylation of trifluoroethanol by dual Nickel/Photoredox catalysis. ANGEW, 64(21), e202424324. (www)

  @article{ , abstract = {Serving as a bioisostere for methyl groups, the incorporation of the trifluoromethyl group (CF 3 ) has become a key area of interest in pharmaceutical lead optimization for its unique combination of steric bulk and high electronegativity. Recognizing the widespread application of optically pure α-methyl-α-hydroxy carbon centers in drug molecules, the introduction of α-hydroxytrifluoroethyl groups into stereogenic centers holds significant potential. Herein, we describe an asymmetric trifluoroalkylation protocol utilizing nickel/photoredox cocatalysis to synthesize enantioenriched α-trifluoromethyl acyloins via a 1,2-hydrogen atom migration strategy. Density functional theory calculations guided the reaction design, revealing hydrogen-bonding interactions within the transition state that control the chiral outcome. The resulting products can be further reduced through a one-pot process to yield fluoroalkyl-1,2- anti -diols with adjacent stereocenters. This hydrogen-bonding synergistic methodology demonstrates excellent stereochemical control, mild conditions, and broad functional group tolerance, enabling the efficient asymmetric trifluoroalkylation of complex molecules and offering new avenues for chiral drug development.}, archive = {J_ANGEW}, author = {Yuan-Bo Li and Duo-Duo Hu and Wei-Ran Ren and Hang Liu and Yu-Lin Wang and Kuiliang Li and Wen-Chang Ke and Ruo-Xing Jin and Xi-Sheng Wang}, doi = {10.1002/anie.202424324}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424324}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen bonding interaction enabled asymmetric C─H acylation of trifluoroethanol by dual Nickel/Photoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Silylation of aryl and alkyl chlorides by a seven-membered dialkoxysilyl group Si(pan)Me via an in situ generated silylpotassium. ANGEW, 64(21), e202424183. (www)

  @article{ , abstract = {Silicon-containing compounds are increasingly vital in pharmaceutical and agrochemical applications, yet existing silylation methods face critical limitations: poor reactivity of unactivated silanes and instability of activated silylation reagents and their products. Here, we present a seven-membered dialkoxysilyl unit, dioxasilepane, abbreviated as Si(pan), that combines exceptional stability with controllable reactivity. We demonstrate a versatile method for Si(pan)Me incorporation into organic molecules through reactions with diverse aryl, alkenyl, and alkyl chlorides. Notably, we have isolated and structurally characterized the key silylpotassium intermediate as its 18-crown-6 complex through X-ray crystallography. Experimental mechanistic studies reveal that this silylpotassium species mediates the transformation primarily through halogen-metal exchange (HME). Computational investigations confirm the HME pathway while suggesting a concurrent S N 2 mechanism for specific primary alkyl chlorides. This methodology establishes Si(pan) as a robust building block for constructing silicon-containing molecular frameworks, addressing a longstanding challenge in organic synthesis.}, archive = {J_ANGEW}, author = {Kenshiro Hitoshio and Jun Shimokawa and Hideki Yorimitsu}, doi = {10.1002/anie.202424183}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Silylation of aryl and alkyl chlorides by a seven-membered dialkoxysilyl group Si(pan)Me via an in situ generated silylpotassium}, volume = {64}, year = {2025}, }
• (2025). A DNP-supported solid-state NMR approach to study nucleic acids in situ reveals berberine-stabilized hoogsteen structures in mitochondria. ANGEW, 64(21), e202424131. (www)

  @article{ , abstract = {Mitochondria are central to cellular bioenergetics, with the unique ability to translate and transcribe a subset of their own proteome. Given the critical importance of energy production, mitochondria seem to utilize higher-order nucleic acid structures to regulate gene expression, much like nuclei. Herein, we introduce a tailored approach to probe the formation of such structures, specifically G-quadruplexes, within intact mitochondria by using sensitivity-enhanced dynamic nuclear polarization-supported solid-state NMR (DNP-ssNMR). We acquired NMR spectra on isolated intact isotopically labeled mitochondria treated with berberine, a known high-affinity G-quadruplex stabilizer. The DNP-ssNMR data revealed spectral changes in nucleic acid sugar correlations, increased signal intensity for guanosine carbons, and enhanced Hoogsteen hydrogen bond formation, providing evidence of in vivo G-quadruplex formation in mitochondria. Together, our workflow enables the study of mitochondrial nucleic acid-ligand interactions at endogenous concentrations within biologically relevant environments by DNP-ssNMR, thus paving the way for future research into mitochondrial diseases and their potential treatments.}, archive = {J_ANGEW}, author = {Michaela Dzurov Krafčíková and David Beriashvili and Salima Bahri and Menno Bergmeijer and Stuart C. Howes and Andrei Gurinov and Friedrich G. Förster and Gert E. Folkers and Marc Baldus}, doi = {10.1002/anie.202424131}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424131}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A DNP-supported solid-state NMR approach to study nucleic acids in situ reveals berberine-stabilized hoogsteen structures in mitochondria}, volume = {64}, year = {2025}, }
• (2025). Engineering aqueous electrolytes with vicinal S-based organic additives for highly reversible zinc-ion batteries. ANGEW, 64(21), e202424095. (www)

  @article{ , abstract = {The commercial deployment of aqueous zinc-ion batteries (AZIBs) is hampered by dendrites, the hydrogen evolution reaction (HER), and corrosion reactions. To tackle these challenges, we have introduced 3,3′-dithiobis-1-propanesulfonic acid disodium salt (SPS), a symmetrical sulfur-based organic salt, as an electrolyte additive for AZIBs. Unlike conventional electrolyte additives that favor (002) deposition, SPS enables dense (100) growth through a unique symmetrically aligned concentration-controlled adsorption network, affording structural uniformity and compactness to the Zn deposit layer. The dual-action symmetrical SPS additive adsorbs onto the Zn surface via vicinal sulfur atoms, blocking electrolyte access to the Zn anode, enhancing the transportation kinetics of Zn 2+ , and simultaneously promoting desolvation by displacing water molecules from the solvation shell. This synergistic effect improves the stability of the Zn anode by mitigating HER and corrosion, resulting in over 1100 h of cycling at 5 mA cm −2 , 5 mAh cm −2 , stable operation at even 15 mA cm −2 , 15 mAh cm −2 , and achieving impressive Coulombic efficiency (CE) of 99.41%. As validation, the Zn/NaV 3 O 8 ·1.35H 2 O cell with SPS-additive afforded high cycling stabilization and excellent capacity retention of 95.5%. This study offers valuable insights for advancing AZIBs and other metal-based batteries.}, archive = {J_ANGEW}, author = {Teng Li and Ahmad Naveed and Jiongzhi Zheng and Bixian Chen and Mingfeng Jiang and Biyuan Liu and Yu Zhou and Xiaowei Li and Mingru Su and Ruiqiang Guo and Joy Sumner and Cheng Chao Li and Yunjian Liu}, doi = {10.1002/anie.202424095}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering aqueous electrolytes with vicinal S-based organic additives for highly reversible zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Surface nonbonding oxygen state regulation for reversible anionic redox chemistry in li-rich mn-based layered oxides. ANGEW, 64(21), e202424079. (www)

  @article{ , abstract = {Activated by the Li–O–Li configuration with nonbonding O 2p state (lO 2p ), anionic redox reaction (ARR) in Li-rich layered oxides (LLOs) contributes to additional capacity but exhibits significant irreversibility, leading to severe surface oxygen loss. Herein, surface nonbonding oxygen state (SNBOS) is regulated by the integrated surface structure engineering to suppress surface oxygen loss and enhance the reversibility of ARR. On the outermost layer, the conversion of layered structure into a LiLaO 2 layer and spinel phase structure eliminates lO 2p , thereby preventing the activation of ARR and suppressing side reactions between electrolyte and oxidized oxygen ions. Besides, by introducing 5d metal La on the near surface, the energy of lO 2p is decreased corresponding to the increased charge-transfer gap Δ and the d–d coulomb repulsion term U is reduced, making U/2 decrease close to Δ and enhancing ARR reversibility. Furthermore, it is demonstrated that the oxidized oxygen of the modified sample cannot become O 2 gas and escape, but rather exists more in the form of high-valence oxygen dimer anions , reducing the reaction depth of surface ARR and inhibiting oxygen loss. Therefore, the designed material demonstrates outstanding cycling stability and kinetics performance.}, archive = {J_ANGEW}, author = {Shihao Li and Fangyan Liu and Shuai Zhang and Xianggang Gao and Wei Zhou and Yangyang Xie and Yanqing Lai and Zhian Zhang}, doi = {10.1002/anie.202424079}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424079}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface nonbonding oxygen state regulation for reversible anionic redox chemistry in li-rich mn-based layered oxides}, volume = {64}, year = {2025}, }
• (2025). Highly stereoselective 1,2-cis-xylosylation enabled by reagent modulation, remote participation, and electron-withdrawing synergistic effects. ANGEW, 64(21), e202424048. (www)

  @article{ , abstract = {Stereoselective constructions of 1,2- cis -glycosidic bonds are long-standing challenges in chemical synthesis. In particular, achieving highly stereoselective 1,2- cis -xylosylation remains a difficult task in carbohydrates chemistry. Here, we report that highly stereoselective 1,2- cis -xylosylation could be achieved via synergistic combinations of reagent modulation, remote participation, and electron-withdrawing effects. A variety of α-xylosides motifs have been effectively prepared by this 1,2- cis -xylosylation protocol, including hemicellulose xyloglucan, xyloglucosyl trisaccharide motif from mammalian cells, core M3 matriglycan motif, and even α-(1→3)-xylosides up to 12-mer. Furthermore, DFT calculations provided the origins of this stereoselective and synergistic 1,2-cis-xylosylation through S N 1 and S N 2 pathways.}, archive = {J_ANGEW}, author = {Jie Wan and Yujie Ji and Leilei Wang and Rui Yang and Kaifeng Li and Qingyun Xian and Xiufang Wang and Gang Lu and Guozhi Xiao}, doi = {10.1002/anie.202424048}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202424048}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly stereoselective 1,2-cis-xylosylation enabled by reagent modulation, remote participation, and electron-withdrawing synergistic effects}, volume = {64}, year = {2025}, }
• (2025). Leaflet-specific structure and dynamics of solid and polymer supported lipid bilayers. ANGEW, 64(21), e202423784. (www)

  @article{ , abstract = {Polymer-supported or tethered lipid bilayers serve as versatile platforms for mimicking plasma membrane structure and dynamics, yet the impact of polymer supports on lipid bilayers remains largely unresolved. In this study, we introduce a novel methodology that combines graphene-induced energy transfer (GIET) with line-scan fluorescence lifetime correlation spectroscopy (lsFLCS) to examine the structural and dynamic properties of lipid bilayers. Our findings reveal that polymer supports markedly influence both the structural parameters, such as the membrane height from the substrate, its thickness, as well as dynamic properties, including leaflet-specific diffusion coefficients and interleaflet coupling. These findings highlight the complex interplay between a polymer support and the lipid bilayers. By resolving leaflet-specific diffusion and heights of the two leaflets from the substrate, this study emphasizes the potential of GIET-lsFLCS for probing membrane dynamics and structure. These insights significantly advance the understanding and application of polymer-supported membranes across diverse research contexts.}, archive = {J_ANGEW}, author = {Narain Karedla and Falk Schneider and Jörg Enderlein and Tao Chen}, doi = {10.1002/anie.202423784}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423784}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leaflet-specific structure and dynamics of solid and polymer supported lipid bilayers}, volume = {64}, year = {2025}, }
• (2025). Activating molybdenum peroxide scissors for converting polyamide plastic into low carbon alcohols. ANGEW, 64(21), e202423766. (www)

  @article{ , abstract = {Direct chemical conversion of plastic waste into low-carbon oxygenates, rather than carbon dioxide, with renewable energy, is important yet challenging. Due to high C─X (X═C, H, N) bond energy, fully optimized catalysts are required to enable precise bond cleavage for boosted efficiency and selectivity. Here, adaptable and recyclable molybdenum peroxide photocatalysts that demonstrate chemical scissors for the selective conversion of polyamide to alcohols are reported. It shows that dimensionally adaptable Mo(+5.8)-(O 2 ) is activated via a ligand-to-metal charge transfer (LMCT) process for localized catalysis to precisely cleave C─X bonds into C 2 and C 1 alcohols. The additional hydrogen peroxide facilitates the activation and regeneration of the catalytic scissors. These scissors ultimately cut PA6 into methanol with an efficiency of 2.55 mmol L −1 h −1 and a selectivity of 82.4 %. This work provides insights into the role of adaptable metal peroxides in precisely cutting C─X bonds, which benefits chemical conversion of plastic wastes.}, archive = {J_ANGEW}, author = {Miao Kan and Meng Tao and Weijie Zhuang and Shiqun Wu and Li Wan and Yong Wang and Jinlong Zhang}, doi = {10.1002/anie.202423766}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423766}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activating molybdenum peroxide scissors for converting polyamide plastic into low carbon alcohols}, volume = {64}, year = {2025}, }
• (2025). Chemical bonds containing hydrogen: Choices for hydrogen carriers and catalysts. ANGEW, 64(21), e202423661. (www)

  @article{ , abstract = {Compounds containing B─H, C─H, N─H, or O─H bonds with high hydrogen content have been extensively studied as potential hydrogen carriers. Their hydrogen storage performance is largely determined by the nature of these bonds, decomposition pathways, and the properties of the dehydrogenation products. Among these compounds, methanol, cyclohexane, and ammonia stand out due to their low costs and established infrastructure, making them promising hydrogen carriers for large-scale storage and transport. They offer viable pathways for decarbonizing society by enabling hydrogen to serve as a clean energy source. However, several challenges persist, including the high temperatures required for (de)hydrogenation, slow kinetics, and the reliance on costly catalysts. To address these issues, strategies such as chemical modification and catalyst development are being pursued to improve hydrogen cycling performance. This review highlights recent progress in hydrogen carriers with B─H, C─H, N─H, or O─H bonds. It examines the fundamental characteristics of these bonds and carriers, as well as advances in catalyst development. Our objective is to offer a comprehensive understanding of current state of hydrogen carriers and identify future research directions, such as molecular modification and system optimization. Innovations in these areas are crucial to advance hydrogen storage technologies for a large-scale hydrogen deployment.}, archive = {J_ANGEW}, author = {James Cashel and Dai Yan and Rui Han and Hyangsoo Jeong and Chang Won Yoon and John Arnold Ambay and Yongfeng Liu and Alison T. Ung and Limei Yang and Zhenguo Huang}, doi = {10.1002/anie.202423661}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical bonds containing hydrogen: Choices for hydrogen carriers and catalysts}, volume = {64}, year = {2025}, }
• (2025). 1,2-bis-triazenylarenes enable vicinal sandmeyer-type reactions. ANGEW, 64(21), e202423498. (www)

  @article{ , abstract = {The introduction of two nucleophiles in the vicinal position of arenes via Sandmeyer-type reactions is compromised by the problematic diazotization of ortho -diaminoarenes. Herein, it is shown that vicinal substitution reactions are facilitated by the use of 1,2-bis-triazenylarenes. Two distinct methodologies for the synthesis of these triazenes are presented. The first approach involves the sequential conversion of 1-amino-2-iodoarenes into first mono- and then bis-triazenylarenes. The second procedure is based on Ru-catalyzed [2 + 2 + 2] cycloaddition reactions between diynes and a 1,2-bis-triazenylalkyne. The two triazene groups in the products can be substituted sequentially by a range of nucleophiles including fluoride, chloride, bromide, iodide, azide, hydroxide, methoxide, and acetamide.}, archive = {J_ANGEW}, author = {Christeena Mathew and Anastasia Yu. Gitlina and Carl Thomas Bormann and Farzaneh Fadaei-Tirani and Alexandre Genoux and Kay Severin}, doi = {10.1002/anie.202423498}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423498}, shortjournal = {Angew. Chem. Int. Edit.}, title = {1,2-bis-triazenylarenes enable vicinal sandmeyer-type reactions}, volume = {64}, year = {2025}, }
• (2025). From polymers to rings and back again: Chemical recycling of polyesters to macrolactones. ANGEW, 64(21), e202423478. (www)

  @article{ , abstract = {Cyclic anhydride and epoxide ring-opening copolymerization is a versatile and controlled route to make polyesters, gaining attention in different application sectors. But so far, the chemical recycling of these polyesters to cyclic monomers is under-explored. Here, the catalytic chemical recycling of aliphatic polyesters to selectively form 16- and 18-membered lactones is presented. The recycling reactions are catalyzed using commercial tin(II) octoate and conducted in the polymer melt (230 °C) resulting in high conversions to the macrolactones (>90%). The recycled macrolactones undergo catalyzed ring-opening polymerizations to produce polyesters with equivalent properties to the virgin materials.}, archive = {J_ANGEW}, author = {Madeleine L. Smith and Thomas M. McGuire and Ryan W. F. Kerr and Charlotte K. Williams}, doi = {10.1002/anie.202423478}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423478}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From polymers to rings and back again: Chemical recycling of polyesters to macrolactones}, volume = {64}, year = {2025}, }
• (2025). α-methyl group reinforced amphiphilic Poly(Ionic liquid) additive for high-performance Zinc–Iodine batteries. ANGEW, 64(21), e202423326. (www)

  @article{ , abstract = {Aqueous zinc–iodine (Zn–I 2 ) batteries are prospective on energy storage, yet the practical application is severely hindered by side reactions of Zn metal and the shuttle effects for polyiodide. Herein, a polymer additive was copolymerized by 1-vinyl-3-ethylimidazolium trifluoromethanesulfonate (VEImOTf) and methacrylamide (MAAm) (PVEMA) to alleviate the above issues. The polymer chain of PVEMA endows amphipathic properties for Zn 2+ diffusion and solvation structure regulation, and the α-methyl of MAAm enhances the hydrophobic properties to avoid side reactions on Zn metal. In addition, the imidazole groups adsorb onto Zn metal with electrostatic shielding effect for further side reaction alleviation and mitigate shuttle effects by electrostatic interactions with polyiodides. Consequently, the PVEMA confers the symmetrical Zn battery with great cycling stability for over 400 h at 20 mA cm −2 and high depth of discharge (DOD) of 77.7%. The Zn–I 2 batteries with PVEMA also demonstrate stable cycling performance under various current densities and temperatures.}, archive = {J_ANGEW}, author = {Chen Wu and Yifan Pan and Yucong Jiao and Peiyi Wu}, doi = {10.1002/anie.202423326}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423326}, shortjournal = {Angew. Chem. Int. Edit.}, title = {α-methyl group reinforced amphiphilic Poly(Ionic liquid) additive for high-performance Zinc–Iodine batteries}, volume = {64}, year = {2025}, }
• (2025). Immunoengineering of a photocaged 5´-triphosphate oligoribonucleotide ligand for spatiotemporal control of RIG-I activation in cancer. ANGEW, 64(21), e202423321. (www)

  @article{ , abstract = {Photochemical control of oligonucleotides bears great potential for the spatio-temporal control of therapeutic targets, such as immune sensing receptors. Retinoic acid-inducible gene I (RIG-I) is a cytoplasmic receptor of the innate immune system that triggers antiviral responses upon detection of viral RNA. RIG-I can be specifically activated by short double-stranded (ds) RNA with a blunt 5′ end bearing a triphosphate, mimicking nascent viral transcripts. Tumor cells are specifically sensitive to RIG-I-induced cell death. Here we developed a potent oligonucleotide ligand for spatiotemporally controlled activation of RIG-I by light exposure. Through structural considerations and functional studies we identified a combination of two nucleoside positions in a RIG-I oligonucleotide ligand for which the substitution of both respective 2′-hydroxy groups of the ribose by photolabile protecting groups (2′-photocages) resulted in a complete loss of RIG-I ligand activity, whereas photocaging the individual positions was not sufficient to turn off RIG-I. Light exposure fully restored RIG-I activation by the photocaged RIG-I ligand, enabling light-controlled RIG-I-mediated cell death of human cancer cells which had internalized the photocaged RIG-I ligand prior to light exposure. This novel photoactivatable RIG-I oligonucleotide ligand may be applicable for precise light-controlled induction of tumor cell death in superficial cancer such as melanoma.}, archive = {J_ANGEW}, author = {Sandra Anika Lewash and Vivien Rose McKenney and Christine Wuebben and Janos Ludwig and Racha Hosni and Dirk Radzey and Marieta I. Toma and Eva Bartok and Martin Schlee and Thomas Zillinger and Alexander Heckel and Gunther Hartmann}, doi = {10.1002/anie.202423321}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423321}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Immunoengineering of a photocaged 5´-triphosphate oligoribonucleotide ligand for spatiotemporal control of RIG-I activation in cancer}, volume = {64}, year = {2025}, }
• (2025). Breaking linear scaling relation limitations on a dual-driven single-atom copper-tungsten oxide catalyst for ammonia synthesis. ANGEW, 64(21), e202423154. (www)

  @article{ , abstract = {Electrocatalytic reduction of nitrate (NO 3 − , NO3RR) on single-atom copper catalysts (Cu-SACs) offers a sustainable approach to ammonia (NH 3 ) synthesis using NO 3 − pollutants as feedstocks. Nevertheless, this process suffers from inferior NO3RR kinetics and nitrite accumulation owing to the linear scaling relation limitations for SACs. To break these limitations, a single-atom Cu-bearing tungsten oxide catalyst (Cu 1 /WO 3 ) was developed, which mediated a unique dual-driven NO3RR process. Specifically, WO 3 dissociated water molecules and supplied the Cu 1 site with ample protons, whereas the Cu 1 site in an electron-deficient state converted NO 3 − to NH 3 efficiently. The Cu 1 /WO 3 delivered an impressive NH 3 production rate of 1274.4 mg N h −1 g Cu −1 , a NH 3 selectivity of 99.2%, and a faradaic efficiency of 93.7% at −0.60 V, surpassing most reported catalysts. Furthermore, an integrated continuous-flow system consisting of a NO3RR cell and a vacuum-driven membrane separator was developed for NH 3 synthesis from nitrate-contaminated water. Fed with the Yangtze River water containing ∼22.5 mg L −1 of NO 3 − -N, this system realized an NH 3 production rate of 325.9 mg N h −1 g Cu −1 and a collection efficiency of 98.3% at energy consumption of 17.11 kwh g N −1 . This study provides a new dual-driven concept for catalyst design and establishes a foundation for sustainable NH 3 synthesis from waste.}, archive = {J_ANGEW}, author = {Fei Shen and Shuxian He and Xiangyi Tang and Yinan Liu and Yuying Wang and Yanjun Yin and Xiaoshu Lv and Wenyang Fu and Yan Zou and Guangming Jiang and Li'an Hou}, doi = {10.1002/anie.202423154}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423154}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking linear scaling relation limitations on a dual-driven single-atom copper-tungsten oxide catalyst for ammonia synthesis}, volume = {64}, year = {2025}, }
• (2025). Lithium-containing hybrid SEI layer enabling high mass loading and anode-less sodium metal batteries. ANGEW, 64(21), e202423090. (www)

  @article{ , abstract = {The continuous rupturing and rebuilding of unstable solid electrolyte interphase (SEI) layer during cycling would block Na + diffusion and induce Na dendrite formation, ultimately limiting the practical application of high-energy-density sodium metal batteries. Herein, a hybrid SEI layer containing Li-species is dexterously constructed on the surface of sodium metal anode. Li-containing inorganic components (Li 3 N, LiF, and Li 2 CO 3 ) are introduced to stabilize the Na/electrolyte interface and enhance the mechanical and diffusion kinetic properties of the SEI layer, which can reduce the side reactions and gas generation, regulate Na + flux during cycling and promote rapid Na + migration for uniform dendrite-free Na deposition. As a result, the constructed Na symmetric cells achieve low overpotential and long cycle life of 5900, 1800, and 500 h at current densities of 3, 10, and 30 mA cm −2 , respectively. Furthermore, the full cells paired with the Na₃V₂(PO₄)₃ cathode demonstrate high specific capacity and excellent cycle stability, even at an ultra-high cathode loading of 39.3 mg cm −2 and a low N/P ratio (negative/positive electrode capacity ratio of 1.21).}, archive = {J_ANGEW}, author = {Li Xia and Liang Lin and Jiantao Li and Yinggan Zhang and Hongfei Zheng and Xiaoqing Chang and Jinding Liang and Baisheng Sa and Laisen Wang and Jie Lin and Dong-Liang Peng and Khalil Amine and Qingshui Xie}, doi = {10.1002/anie.202423090}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423090}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lithium-containing hybrid SEI layer enabling high mass loading and anode-less sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Aqueous dehydrogenation of methyl formate catalyzed by a recyclable polymer-grafted Manganese(I) pincer complex. ANGEW, 64(21), e202423074. (www)

  @article{ , abstract = {Liquid organic hydrogen carriers (LOHCs) are an effective solution for the long-term storage of hydrogen and its long-distance transportation, but one that requires efficient catalysis for hydrogen uptake and release. Homogeneous molecular catalysts employed in LOHC systems usually exhibit high reactivity and selectivity but are difficult to recover and reuse, a fact that severely limits their practical application. Herein, we report an easily synthesized polymer-grafted pincer-type complex of earth-abundant manganese, which can catalyze the aqueous dehydrogenation of methyl formate, an emerging LOHC material. Importantly, this immobilized Mn-pincer catalyst retains the high reactivity of the corresponding molecular catalyst, yet is also recyclable, exhibiting high stability and achieving a total hydrogen-based turnover number of more than 230000 after 5 consecutive recycling rounds.}, archive = {J_ANGEW}, author = {Lijun Lu and Cai You and Michael Montag and Ayan Maity and Michal Leskes and David Milstein}, doi = {10.1002/anie.202423074}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202423074}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aqueous dehydrogenation of methyl formate catalyzed by a recyclable polymer-grafted Manganese(I) pincer complex}, volume = {64}, year = {2025}, }
• (2025). Polarization-induced quantum confinement of negative charge carriers by organic nanoporous frameworks. ANGEW, 64(21), e202422923. (www)

  @article{ , abstract = {We characterize the attachment of excess-electrons to organic nanoporous systems such as molecular nanohoops and models of covalent organic frameworks (COFs) using many-body methods. All the nanopore systems exhibit diffuse electronic states where the excess-electron is bound to the molecular scaffold via long-range polarization forces, and the excess-electron is predominantly localized in the interior of the nanopore or away from the molecular scaffold. Such “nanopore-bound” states show an enhanced electron-transfer coupling compared to more strongly-bound skeletal-states (or valence-bound states), where the excess-electron is confined to the molecular skeleton. For 1D assemblies of nanohoops, the bands formed from nanopore-bound states have a consistent nearly-free-electron character, indicating an efficient excited-state pathway for charge-carriers, while the bands from skeletal-states have higher effective mass along certain lattice directions. The nanopore-bound states show distinct size-dependent variations in electron affinities compared to skeletal-states and previously observed molecular quantum corral states. We conclude that nanopore-bound states emerge from polarization-induced quantum confinement, forming a distinct common feature of organic nanoporous matter with potential for efficient electron-transport.}, archive = {J_ANGEW}, author = {Ritaj Tyagi and Vamsee K. Voora}, doi = {10.1002/anie.202422923}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202422923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polarization-induced quantum confinement of negative charge carriers by organic nanoporous frameworks}, volume = {64}, year = {2025}, }
• (2025). Self-assembly of short peptides activates specific ER-phagy and induces pyroptosis for enhanced tumor immunotherapy. ANGEW, 64(21), e202422874. (www)

  @article{ , abstract = {Developing specific endoplasmic reticulum-autophagy (ER-phagy) inducers is highly desirable for discovering new ER-phagy receptors and elucidating the detailed ER-phagy mechanism and potential cancer immunotherapy. However, most of the current ER-phagy-inducing methods cause nonselective autophagy of other organelles. In this work, we report the design and synthesis of simple and stable short peptides ( D-FFxFFs ) that could specifically trigger ER-phagy, which further induces pyroptosis and activates the immune response against tumor cells. D-FFxFFs locate preferentially in ER and readily self-assemble to form nanosized misfolded protein mimics, which lead to distinct upregulation of dedicated ER-phagy receptors with no obvious autophagy of other organelles. Significant unfolded protein response (UPR) is activated via IRE1-JNK and PERK-ATF4 pathways. Interestingly, the persistent ER-phagy triggers ER Ca 2+ release and a surge in mitochondrial Ca 2+ levels, resulting in GSDMD-mediated pyroptosis other than apoptosis. The ER-phagy induces pyroptosis and activates a distinct antitumor immune response without evolving the acquired drug resistance. This work not only provides a powerful tool for investigating the mechanism and function of ER-phagy but also offers an appealing strategy for anticancer immunotherapy.}, archive = {J_ANGEW}, author = {Yunhua Zhang and Chengyuan Qian and Chengyan Chu and Xiu-Zhi Yang and Yanping Wu and Linxiang Cai and Shankun Yao and Weijiang He and Zijian Guo and Yuncong Chen}, doi = {10.1002/anie.202422874}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202422874}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembly of short peptides activates specific ER-phagy and induces pyroptosis for enhanced tumor immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Transaminase-triggered cascades for the synthesis and dynamic kinetic resolution of chiral N-heterocycles. ANGEW, 64(21), e202422584. (www)

  @article{ , abstract = {Biocatalysis is now a well-established branch of catalysis and the growing toolbox of natural, evolved and designer enzymes is enabling chemistry previously deemed inaccessible. However, most enzyme methodologies have been developed for functional group interconversions, such as the conversion of a ketone into an amine or alcohol, and do not result in the generation of significant 3D molecular complexity. The application of enzyme-triggered reaction cascade methodologies has the potential to transform simple substrates into complex sp 3 -rich molecules in one step. Herein, we describe a single-step biocatalytic route to high-value, complex indolizidine, and quinolizidine alkaloids, which relies on a transaminase-triggered double intramolecular aza-Michael reaction. This approach allows access to architecturally complex, natural-product-like N -heterocycles and reveals intriguing examples of diastereoselectivity in these enzyme-triggered reactions. Significantly, we demonstrate an elegant example of a biocatalytic cascade where the transaminase plays a dual role in generating complex N -heterocycles and where a retro-double intramolecular aza-Michael reaction mediates a dynamic kinetic resolution and enables the isolation of sp 3 -rich indolizidine diastereoisomers containing five stereocenters, as single isomers.}, archive = {J_ANGEW}, author = {Adam O'Connell and Marianne B. Haarr and James Ryan and Xingxing Xu and Aoife Martin and Simon N. Smith and Nadia Elghobashi-Meinhardt and Patricia Fleming and Beatriz Maciá and Vittorio Caprio and Elaine O'Reilly}, doi = {10.1002/anie.202422584}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202422584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transaminase-triggered cascades for the synthesis and dynamic kinetic resolution of chiral N-heterocycles}, volume = {64}, year = {2025}, }
• (2025). A versatile route to shape polymer nanoparticles by deforming nanoreactors made from magnetic surfactants. ANGEW, 64(21), e202422439. (www)

  @article{ , abstract = {Directions are equivalent in an amorphous system, so anisotropy cannot emerge of its own accord, resulting in a gap for preparing polymer nanoparticles deviating from a spherical shape. Unlike inorganic nanocrystals for which faceting controls shape, polymers are not directly available as rod-like particles, for instance. Here, we show a highly versatile, nontoxic, novel approach to break this paradigm and obtain polymer nanorods by emulsion polymerization using a unique surfactant comprising a magnetic head group. Surprisingly, even applying a weak magnetic field to the magnetic surfactant within an emulsion polymerization transforms diamagnetic polymers into rod-like nanoparticles instead of their usual spherical shapes. The polarization in a magnetic field exerts a torque on the molecular structure, and as a result, the emulsion droplets deform. The method can be applied to different polymers such as polystyrene, polymethylmethacrylate, or polythiophene. The magnetic surfactant is recovered quantitatively and can be reused; one obtains metal-free polymer particles, and the process is sustainable. The straightforward approach presented here will unlock several applications of these previously inaccessible polymer nanorods, particularly in the case of conducting polymers.}, archive = {J_ANGEW}, author = {Benjamin Botev and Stephan Siroky and Irene Morales and Sebastian Polarz}, doi = {10.1002/anie.202422439}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202422439}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A versatile route to shape polymer nanoparticles by deforming nanoreactors made from magnetic surfactants}, volume = {64}, year = {2025}, }
• (2025). Alternating binary droplets-based protocell networks driven by heterogeneous Liquid–Liquid phase separation. ANGEW, 64(21), e202422175. (www)

  @article{ , abstract = {As the emergence of prototissues promotes the evolutionary transformations of protolife, tissue-like networks derived from cytomimetic systems have been studied by using artificial cells as building blocks to mimic prototissues at a higher organizational level. However, liquid-like networks originating from liquid–liquid phase separation (LLPS), especially heterogeneous LLPS, are less reported. Herein, we report a binary liquid droplet-based protocell network composed of coacervates and aqueous two-phase systems (ATPS) droplets arranged in an alternating sequence, integrating both associative and segregative LLPS. This network with worm-like chains can be specifically achieved only when the attached droplets are partially engulfed, mediated by the interfacial tension between coacervate and ATPS droplets. Notably, the interconnected droplets within the network are capable of spatially self-sorting of biomacromolecules into separate domains, thereby facilitating biomacromolecular extraction and biological reactions within designated droplets. Upon changes in the external environment, the network can be reconfigured to enable morphological regulation of trienzymatic cascade reactions. Overall, this work highlights that an all-aqueous network, coupling both associative and segregative LLPS, can be engineered as a possible route toward a hybrid prototissue-like system, offering new insights into the design of higher-ordered biomimetic systems utilizing liquid soft matter.}, archive = {J_ANGEW}, author = {Jianing Hu and Junbo Li and Jian Liu and Yan Huang and Mei Zhu and Chunxia Chen and Wei Ji and Xin Huang}, doi = {10.1002/anie.202422175}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202422175}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alternating binary droplets-based protocell networks driven by heterogeneous Liquid–Liquid phase separation}, volume = {64}, year = {2025}, }
• (2025). Electrophotocatalysis for reductive defluorination of PTFE and PFASs. ANGEW, 64(21), e202422043. (www)

  @article{ , abstract = {Polytetrafluoroethylene (PTFE) is among the most inert poly- and perfluoroalkyl substances (PFASs) and its degradation under mild conditions remains underdeveloped. We report a supercapacitor-assisted electrophotocatalysis, incorporating the strength of both electrochemical and photochemical energy, for the efficient defluorination of PTFE and other PFASs at low temperatures. CBZ6 worked as a photoreductant for injecting electrons into the inert carbon–fluorine bond, whereas the supercapacitor enabled the generation of the catalytically active species via an electrophotochemical process. Furthermore, the utilization of sunlight as the light source and supercapacitor as the electrical energy source makes the reaction portable and enables its outdoor applications.}, archive = {J_ANGEW}, author = {Jia-Le Fu and Yu Liu and Yi-Ming Chen and Hao Zhang and Jian-Ping Qu and Yan-Biao Kang}, doi = {10.1002/anie.202422043}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202422043}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrophotocatalysis for reductive defluorination of PTFE and PFASs}, volume = {64}, year = {2025}, }
• (2025). Uncovering chemical principles governing nanophase formation in ternary solvents. ANGEW, 64(21), e202421167. (www)

  @article{ , abstract = {Nanoscopic phases, such as oil-enriched pockets dispersed in water, have been observed in ternary mixtures of oil, water, and cosolvent in the absence of surfactants. Such nanophases are found across a portion of compositions within the single-phase region of the ternary phase diagram. However, the principles governing the formation of nanophases under certain conditions but not others, regarding both volumetric and chemical makeup, are unclear. Here, the nanophase behavior of ternary mixtures of water with a suite of cosolvents and oils containing strategically chosen functional groups is systematically analyzed to probe the role of intermolecular interactions. Dynamic light scattering is used to quantify the nanophase structure. It was found that stronger classes of intermolecular interactions such as H-bonding or n –Π* interactions between oil and cosolvent notably contribute to forming thermodynamically stable nanophases. Ternary mixtures in which the oil has only van der Waals interactions with the water and cosolvent do not stabilize nanophases detectable by dynamic light scattering. Aromatic groups favor nanophase formation. The most prominent structuring (highest number and largest sizes of nanophases) is found in water-rich compositions near the miscibility gap. This experimental study provides chemical insight into the chemical formulation of ternary solvent mixtures favoring nanophase formation.}, archive = {J_ANGEW}, author = {Binish Ashfaq and Ayusman Sen and Lauren D. Zarzar}, doi = {10.1002/anie.202421167}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202421167}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Uncovering chemical principles governing nanophase formation in ternary solvents}, volume = {64}, year = {2025}, }
• (2025). Ultrarobust, stretchable, and highly elastic supramolecular elastomer with hydrogen-bond interactions via sp2 hybridized boron-urethane bonds. ANGEW, 64(21), e202421099. (www)

  @article{ , abstract = {Elastomers are omnipresent in everyday life and industry, yet the development of an elastomer with both superb stress and toughness presents a prodigious challenge. In this report, a high-strength, tough, and high-elastic elastomer derived from sp 2 hybrid orbitals of phenylboronic acid was designed. The spatial conformation of network becomes significantly more compact due to the sp 2 hybridization of boron. This enhances supramolecular hydrogen bonding interactions, resulting in a marked improvement in the material's mechanical properties. Notably, the hydrogen bonding energy in the polyurethane chain segments enhanced by 37%. The robust hydrogen bonding imparts the elastomer with super high true stress (1.30 GPa), superior toughness (442.2 MJ·m −3 ), and super puncture resistance strength of 167.8·N·mm −1 . The material exhibited excellent fatigue resistance during continuous tensile cycles, while the irreversible deformation disappeared after standing at room temperature. Moreover, the elastomer bespeaks extraordinary elastic restorability, swiftly reverting to its primitive length after being extended to 16 times. This work provides a strategy that the mechanical properties of materials can be enhanced and toughened by utilizing spatial conformational changes in intermolecular interactions.}, archive = {J_ANGEW}, author = {Yuehan Qian and Fuhao Dong and Shanshan Wang and Yunmeng Jiang and Xu Xu and He Liu}, doi = {10.1002/anie.202421099}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202421099}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrarobust, stretchable, and highly elastic supramolecular elastomer with hydrogen-bond interactions via sp2 hybridized boron-urethane bonds}, volume = {64}, year = {2025}, }
• (2025). Exploring the mechanism of surface cationic vacancy induces high activity of metastable lattice oxygen in li- and mn-rich cathode materials. ANGEW, 64(21), e202419664. (www)

  @article{ , abstract = {Li- and Mn-rich layered oxides exhibit high specific capacity due to the cationic and anionic reaction process during high-voltage cycling (≥4.6 V). However, they face challenges such as low initial coulombic efficiency (~70 %) and poor cycling stability. Here, we propose a combination of H 3 BO 3 treatment and low temperature calcination to construct a shell with cationic vacancy on the surface of Li 1.2 Ni 0.2 Mn 0.6 O 2 (LLNMO). The H 3 BO 3 treatment produces cationic vacancy and lattice distortion, forming an oxidized O n − (0< n <2) on the surface, accompanied by electrons redistribution. Low temperature calcination eliminates lattice distortion, activates metastable O n − and promotes coherent lattice formation. In addition, the cationic vacancy shell reduces the diffusion energy barrier of Li + , allowing more Li + and oxygen to participate in deeper reactions and increasing the oxidation depth of oxygen. The modified material (LLNMO-H10-200) exhibits an initial coulombic efficiency of up to 88 % and a capacity of 256 mAh g −1 . Moreover, similar enhancements were observed with Co-containing lithium-rich materials, with a 280 mAh g −1 discharge capacity and 89 % coulombic efficiency. These findings reveal the correlation between cationic vacancy, metastable oxygen activation and bulk phase activity, offering a novel approach to enhancing the initial coulombic efficiency and cycle stability of Li-rich materials.}, archive = {J_ANGEW}, author = {Tian Zhao and Jilu Zhang and Kai Wang and Yao Xiao and Qin Wang and Longfei Li and Jochi Tseng and Meng-Cheng Chen and Jian-Jie Ma and Ying-Rui Lu and Ishii Hirofumi and Yu-Cheng Shao and Xiaoxian Zhao and Sung-Fu Hung and Yaqiong Su and Xiaoke Mu and Weibo Hua}, doi = {10.1002/anie.202419664}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202419664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploring the mechanism of surface cationic vacancy induces high activity of metastable lattice oxygen in li- and mn-rich cathode materials}, volume = {64}, year = {2025}, }
• (2025). Fast sodium ion conductivity in pristine Na8SnP4: Synthesis, structure and properties of the two polymorphs LT-Na8SnP4 and HT-Na8SnP4. ANGEW, 64(21), e202419381. (www)

  @article{ , abstract = {Achieving high ionic conductivities in solid state electrolytes is crucial for the development of efficient all-solid-state-batteries. Considering future availability and sustainability, sodium materials hold promises for an alternative for lithium materials in all-solid-state batteries, due to the higher abundance. Here, we report on a sodium phosphide ion conductor Na 8 SnP 4 with a conductivity of 0.53 mS cm −1 at room temperature as a pristine material. Due to the simple tetrahedral SnP 4 structure units, Na 8 SnP 4 has potential for optimization through aliovalent substitution as successfully applied in sulfide-based materials. Na 8 SnP 4 is easily accessible from exclusively abundant elements and forms a high- and low-temperature polymorph, which further allows for a fundamental understanding of the structure-property relationship. Both polymorphs are structurally characterized by synchrotron X-ray powder diffraction and MAS–NMR spectroscopy. Ion conductivity and activation energy for ion mobility is determined by temperature dependent impedance spectroscopy and static 23 Na-NMR measurements. Both MEM analysis of scattering densities as well as structure determination by Rietveld methods hint for ionic motion between special Na positions in the structure and that ion migration proceeds along pathways passing triangular faces of neighboring tetrahedral and octahedral voids. The specific voids filling in the disordered HT-phase are found to be a crucial parameter for ion migration.}, archive = {J_ANGEW}, author = {Manuel Botta and Samuel Merk and Robert J. Spranger and Anatoliy Senyshyn and Volodymyr Baran and Vadim Dyadkin and Leo van Wüllen and Thomas F. Fässler}, doi = {10.1002/anie.202419381}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202419381}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fast sodium ion conductivity in pristine Na8SnP4: Synthesis, structure and properties of the two polymorphs LT-Na8SnP4 and HT-Na8SnP4}, volume = {64}, year = {2025}, }
• (2025). A structurally simple polymer donor enables high-efficiency organic solar cells with minimal energy losses. ANGEW, 64(21), e202416883. (www)

  @article{ , abstract = {Energy loss ( E loss ) between optical energy gap ( E g ) and open-circuit voltage (e V oc ) sets efficiency upper limits for organic solar cells (OSCs). Nevertheless, further breaking the limit of E loss in OSCs is challenging, especially via structurally simple materials in binary OSCs. Herein, a structurally simple nonhalogenated polymer donor, namely PBDCT, is developed for realizing high-efficiency OSCs with record-breaking E loss . The critical building block 3,4-dicyanothiophene with high electron affinity results in a deep-lying highest occupied molecular orbital (HOMO), which effectively reduces radiative and nonradiative recombination energy losses in OSCs. Meanwhile, the finely tuned alkyl chains offer high crystallinity and low energetic disorder for the polymer, which enables efficient exciton dissociation at low energy loss. Moreover, bi-continuous crystalline fibrillary network structure is formed in the blend consisting of PBDCT due to the optimal aggregation property of the polymer, which is conducive to exciton diffusion and charge transport. Consequently, the OSC with a record-breaking low E loss of 0.476 eV has been achieved, which thereby resulted in a power conversion efficiency (PCE) of 19.84%, the highest value achieved by nonhalogenated polymer donors in binary OSCs to date. This work demonstrates the prospect of breaking the limit of E loss and realizing efficiency breakthroughs in OSCs.}, archive = {J_ANGEW}, author = {Qiuju Jiang and Xiyue Yuan and Yao Li and Yongmin Luo and Jiayuan Zhu and Feixiang Zhao and Yue Zhang and Wenkui Wei and Haozhe Feng and Hongxiang Li and Jiaying Wu and Zaifei Ma and Zheng Tang and Fei Huang and Yong Cao and Chunhui Duan}, doi = {10.1002/anie.202416883}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {21}, pages = {e202416883}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A structurally simple polymer donor enables high-efficiency organic solar cells with minimal energy losses}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Sulfur conversion to donor-acceptor ladder polymer networks through mechanochemical nucleophilic aromatic substitution for efficient CO2 photoreduction (Angew. chem. int. ed. 20/2025). ANGEW, 64(20), e202507727. (www)

  @article{ , archive = {J_ANGEW}, author = {Na Yang and Zi-Jian Zhou and Xiang Zhu and Jiwei Wu and Yifan Zhang and Tao Wang and Xin-Ping Wu and Chengcheng Tian and Xia Jiang and Sheng Dai}, doi = {10.1002/anie.202507727}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202507727}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Sulfur conversion to donor-acceptor ladder polymer networks through mechanochemical nucleophilic aromatic substitution for efficient CO2 photoreduction (Angew. chem. int. ed. 20/2025)}, volume = {64}, year = {2025}, }
• (2025). Emily mevers. ANGEW, 64(20), e202506847. (www)

  @article{ , archive = {J_ANGEW}, author = {Emily Mevers}, doi = {10.1002/anie.202506847}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202506847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Emily mevers}, volume = {64}, year = {2025}, }
• (2025). Ruby sullan. ANGEW, 64(20), e202506727. (www)

  @article{ , archive = {J_ANGEW}, author = {Ruby Sullan}, doi = {10.1002/anie.202506727}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202506727}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ruby sullan}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Roadmap to catalytic abatement of gas phase per- and polyfluoroalkyl substances (PFAS) (Angew. chem. int. ed. 20/2025). ANGEW, 64(20), e202506110. (www)

  @article{ , archive = {J_ANGEW}, author = {Patrick Lott and Florian Maurer and Arik Beck}, doi = {10.1002/anie.202506110}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202506110}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Roadmap to catalytic abatement of gas phase per- and polyfluoroalkyl substances (PFAS) (Angew. chem. int. ed. 20/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Three-electron uric acid oxidation via interdistance-dependent switching pathways in correlated single-atom catalysts for boosting sensing signals (Angew. chem. int. ed. 20/2025). ANGEW, 64(20), e202506107. (www)

  @article{ , archive = {J_ANGEW}, author = {Bowen Jiang and Heng Zhang and Rui Pan and Min Ji and Lin Zhu and Guoju Zhang and Jing Liu and Huihui Shi and Huang Huang and Shu Wan and Kuibo Yin and Litao Sun}, doi = {10.1002/anie.202506107}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202506107}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Three-electron uric acid oxidation via interdistance-dependent switching pathways in correlated single-atom catalysts for boosting sensing signals (Angew. chem. int. ed. 20/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Enantioselective synthesis of chiral ferrocenyl aminoalcohols: Simultaneous induction of multiple types of chirality by a rhodium-catalyzed asymmetric ring-opening strategy. ANGEW, 64(20), e202505856. (www)

  @article{ , archive = {J_ANGEW}, author = {Takamu Isoda and Komei Jimba and Kyohei Kawashima and Takahiro Nishinoiri and Seiji Mori and Akihiro Tsurusaki and Ken Kamikawa}, doi = {10.1002/anie.202505856}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202505856}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Enantioselective synthesis of chiral ferrocenyl aminoalcohols: Simultaneous induction of multiple types of chirality by a rhodium-catalyzed asymmetric ring-opening strategy}, volume = {64}, year = {2025}, }
• (2025). Catalytic asymmetric construction of nonadjacent stereoelements. ANGEW, 64(20), e202504224. (www)

  @article{ , abstract = {Nonadjacent chiral scaffolds are privileged motifs in bioactive molecules and medicines, which have stimulated chemists’ ingenuity in achieving the asymmetric construction of non-contiguous chiral elements directly. Current strategies include bifunctional catalysis, synergistic catalysis, cascade catalysis and others, enabling the production of a wide range of enantiomerically enriched compounds featuring different combinations of nonadjacent chirality, including multiple elements of central chirality, central and allenyl axial chirality, and central and biaryl axial chirality. As compared to the patterns of multiple nonadjacent elements of central chirality, the latter two are less frequently reported. This minireview aims to summarize the key developments in reaction design, mechanistic studies, and synthetic applications, with the goal of stimulating further exploration in this important area of asymmetric catalysis.}, archive = {J_ANGEW}, author = {Chong-Lei Ji and Xi-Zhang Zou and De-Wei Gao}, doi = {10.1002/anie.202504224}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202504224}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic asymmetric construction of nonadjacent stereoelements}, volume = {64}, year = {2025}, }
• (2025). Modulated multicomponent reaction pathway by pore-confinement effect in MOFs for highly efficient catalysis of low-concentration CO2. ANGEW, 64(20), e202503898. (www)

  @article{ , abstract = {The conversion of flue gas CO 2 into high-value chemicals via multicomponent reactions (MCRs) offers the advantages of atom economy, bond-formation efficiency and product complexity. However, because of the competition between reaction sequences and pathways among substrates, the efficient synthesize the desired product is a great challenge. Herein, a porous noble-metal-free framework ( Cu-TCA) was synthesized, which can highly effectively catalyze the multicomponent conversion of CO 2 by modulating reaction pathways. The pores with the size of 6.5 Å×6.5 Å in Cu-TCA selectively permit the entry of propargylamine and CO 2 at simulated flue gas concentrations, At the same time, the larger-sized phosphine oxide is hindered outside the pores. Control experiments and NMR spectroscopy revealed that CO 2 and propargylamine in the pores preferentially reacted to form oxazolidinones, which further reacted with phosphine oxide outside the pores to produce phosphorylated 2-oxazolidinones. Therefore, the reaction pathways and sequence of the substrates were controlled by the confinement effect of the pores in Cu-TCA . Density functional theory (DFT) calculations supported the coordination of Cu-TCA with the alkyne, significantly reducing the reaction barrier and promoting catalytic reaction. This study developed a new strategy for regulating the reaction pathways to promote MCRs via the confinement effect of MOF.}, archive = {J_ANGEW}, author = {Fang-Yu Ren and Chaopeng Hu and Wen-Bin Huang and Ling-Hao Duan and Yun-Zhu Meng and Xiu-Lan Li and Zhi Fang and Xin-Yuan Zhao and Wen Wang and Xiang-Shuai Li and Jian Zhao and Xiang-Yu Zhang and Sheng-Li Hou and Hang Xu and Ying Shi and Liang-Nian He and Bin Zhao}, doi = {10.1002/anie.202503898}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202503898}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulated multicomponent reaction pathway by pore-confinement effect in MOFs for highly efficient catalysis of low-concentration CO2}, volume = {64}, year = {2025}, }
• (2025). High-performance ionogels from dynamic polyrotaxane-based networks. ANGEW, 64(20), e202503307. (www)

  @article{ , abstract = {The swelling of a polymer matrix by ionic liquids and additional lithium salts may lead to the formation of ionogel electrolytes. However, the introduction of additional ions usually results in a decreased lithium-ion transference number, because of the trapping of the lithium ions in clusters and polymer-ion complexes. Achieving highly efficient lithium-ion migration and increasing lithium-ion transference number (t Li + ) are however crucial for the successful application of ionogel electrolytes. Herein, we design a crosslinked polyrotaxane network and then introduce ionic liquid and a lithium salt to obtain an ionogel electrolyte based on the principle of competitive coordination with the lowest binding energy for lithium ions coordinated with both the polymer network and ionic liquid clusters. This facilitates their migration within the ionogel and their release from the coordination environment, thereby improving lithium-ion transport efficiency (ionic conductivity of 2.2×10 −3 S cm −1 and t Li + =0.45 at 20 °C). As proof of concept, the lithium-lithium symmetrical cells achieve stable cycling for 2000 hours, while the NMC622||Li battery demonstrates good rate performance and excellent cycling stability at 20 °C (theoretical initial capacity, 300 cycles with a single cycle capacity loss of 0.03 %). This work provides new insights for the design and synthesis of ionogel electrolytes, facilitating lithium ion migration within the electrolytes.}, archive = {J_ANGEW}, author = {Shanshan Yan and Jinjia Liu and Zhenni He and He Jia and Zehan Chen and Yinghui Zhang and Jean-François Gohy}, doi = {10.1002/anie.202503307}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202503307}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance ionogels from dynamic polyrotaxane-based networks}, volume = {64}, year = {2025}, }
• (2025). Ultrathin polymersomes with controllable light-responsivity via adjusting the electronic effect from para-substituents of azobenzene. ANGEW, 64(20), e202503104. (www)

  @article{ , abstract = {Achieving ultrathin polymersomes (UTPSs) with controllable light-responsive kinetics poses a prospective strategy to address the growing demands of intelligent and miniature systems, but it remains challenging. Herein, we reported the self-assembly of numerous side-chain-type amphiphilic alternating azocopolymers (AAACs) into a series of UTPSs with diameters spanning 210–270 nm and ultrathin vesicular thickness spanning 1.91–2.14 nm. The light-triggered reversible size transitions for these UTPSs are rendered by the photo-isomerization of azobenzene moiety upon alternating irradiation with UV and visible light. The systematical isomerization kinetic study proved that the light-responsive rate of distinct UTPSs was highly dependent on the electronic effect of para -substituents of azobenzenes within AAACs. Notably, the rate constant of electron-withdrawing nitro-modified UTPSs was 6.7 times greater than that of electron-donating hydroxyl-modified UTPSs. The proof-of-concept cargo release activity for different UTPSs was evaluated using a hydrophilic model drug of methylene blue (MB), with a light-controllable releasing performance that highly depended on the para -substituent-induced light-responsive kinetics. Our work offers an innovative strategy to fabricate stimuli-responsive UTPSs with a controllable responsive performance for the targeted applications in bionanotechnology.}, archive = {J_ANGEW}, author = {Zichao Sun and Zejiang Xu and Mingyu Ding and Liquan Wang and Lin Zhao and Pengliang Sui and Guodong Li and Haibao Jin and Yongfeng Zhou and Shaoliang Lin}, doi = {10.1002/anie.202503104}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202503104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrathin polymersomes with controllable light-responsivity via adjusting the electronic effect from para-substituents of azobenzene}, volume = {64}, year = {2025}, }
• (2025). Engineering 2-deoxy-D-ribose-5-phosphate aldolase for anti- and syn-selective epoxidations of α,β-unsaturated aldehydes. ANGEW, 64(20), e202503054. (www)

  @article{ , abstract = {The enzyme 2-deoxy-D-ribose-5-phosphate aldolase (DERA) naturally catalyzes the reversible aldol addition between acetaldehyde and D-glyceraldehyde-3-phosphate to yield 2-deoxy-D-ribose-5-phosphate. Herein we describe the redesign of DERA into a proficient non-natural peroxygenase that promotes the asymmetric epoxidation of various α , β -unsaturated aldehydes. This repurposed aldolase, named DERA-EP, is able to utilize H 2 O 2 to accomplish both anti - and syn -selective epoxidations of various α , β -unsaturated aldehydes to give the corresponding epoxides with moderate to high diastereoselectivity (diastereomeric ratio up to 99 : 1) and excellent enantioselectivity (enantiomeric ratio up to 99 : 1). Crystallographic analysis of DERA-EP in a substrate-free and substrate-bound state provides a structural context for the evolved activity, a clear explanation for the high enantioselectivity, and compelling evidence for catalysis via enzyme-bound iminium ion intermediates. The unprecedented anti -selectivity of DERA-EP with multiple α , β -unsaturated aldehydes is complementary to the syn -selectivity of previously reported enzyme-, metal- and organo-catalysts, making DERA-EP an attractive new asset to the toolbox of epoxidation catalysts.}, archive = {J_ANGEW}, author = {Hangyu Zhou and Andreas Kunzendorf and Guangcai Xu and Hylke O. T. Frietema and Andy-Mark W. H. Thunnissen and Gerrit J. Poelarends}, doi = {10.1002/anie.202503054}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202503054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering 2-deoxy-D-ribose-5-phosphate aldolase for anti- and syn-selective epoxidations of α,β-unsaturated aldehydes}, volume = {64}, year = {2025}, }
• (2025). Integrated electrochemical biomass oxidation and CO2 reduction over ultra-wide potential window. ANGEW, 64(20), e202502846. (www)

  @article{ , abstract = {Electrochemical reduction of carbon dioxide (CO 2 ) coupled with biomass oxidation using renewable electricity is considered as a promising strategy for carbon management. However, achieving both high selectivity and large current density over wide potential window remains a significant challenge, hindering practical applications. In this study, a Ni/Fe dual metal-atom catalyst is developed for CO 2 reduction, achieving nearly 100 % CO selectivity across an ultra-wide potential window of 1.6 V, surpassing state-of-the-art catalysts. Remarkably, this high CO selectivity is maintained above 98 % even after 100 hours of continuous operation at an industrial current density of 200 mA cm −2 , demonstrating excellent long-term stability. When integrated into a solar electricity-driven CO 2 reduction coupled 5-hydroxymethylfurfural oxidation system, nearly 100 % CO Faradaic efficiency and 90 % 2,5-furandicarboxylic acid yield are simultaneously obtained. Theoretical calculations reveal that the rate-limiting step for the CO 2 reduction reaction varies with the applied potential, and the synergistic interaction between Ni and Fe atoms effectively lowers the limiting energy barrier. This work offers valuable insights for the strategic design and synthesis of catalysts with high activity and selectivity across wide potential window, providing a versatile platform for coupling CO 2 reduction with diverse anodic biomass oxidation reactions and renewable energy sources.}, archive = {J_ANGEW}, author = {Chenbao Lu and Sen Yang and Pengfei Shi and Senhe Huang and Chengcheng Cai and Jinhui Zhu and Xiaodong Zhuang and Tianfu Wang}, doi = {10.1002/anie.202502846}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502846}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated electrochemical biomass oxidation and CO2 reduction over ultra-wide potential window}, volume = {64}, year = {2025}, }
• (2025). Dynamic ultralong phosphorescence and optical waveguiding switches in silver-organic complex via reversible single-crystal-to-single-crystal conversion. ANGEW, 64(20), e202502782. (www)

  @article{ , abstract = {Dynamic ultralong room-temperature phosphorescent (RTP) materials with stimuli-responsive properties have attracted considerable interest for applications in sensors, light-emitting devices, and information security. Here, we introduce a novel class of silver (Ag)-organic complexes exhibiting rare, direct ultralong RTP, achieved through the heavy-atom effect of Ag + ions and highly ordered assembly of coordination polymers. The Ag-based complex displays reversible solvent-responsive RTP, shifting from green to yellow emission in response to humidity and solvent variations. This transformation is driven by a solvent-mediated single-crystal-to-single-crystal (SCSC) conversion, enabling color-tunable active optical waveguides and one-dimensional (1D) polarization switching. Therefore, this study provides a new strategy for creating dynamically controllable ultralong all-phosphorescent metal-organic complexes and advances the design of stimuli-responsive 1D photonic systems for promising information encryption and anti-counterfeiting applications.}, archive = {J_ANGEW}, author = {Chang Xing and Zhenhong Qi and Yu-Juan Ma and Dongpeng Yan and Wei-Hai Fang}, doi = {10.1002/anie.202502782}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502782}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic ultralong phosphorescence and optical waveguiding switches in silver-organic complex via reversible single-crystal-to-single-crystal conversion}, volume = {64}, year = {2025}, }
• (2025). Promoting the kinetics of ethylene electrosynthesis via the facet-dependent activation of acetylene over silver catalysts. ANGEW, 64(20), e202502757. (www)

  @article{ , abstract = {Metallic silver (Ag) sites exhibit a robust ability to suppress undesired C−C coupling in the electrocatalytic semihydrogenation of acetylene (C 2 H 2 ) into ethylene (ESAE), leading to satisfactory selectivity and stability. However, the relatively low reaction kinetics still hinder its practical value. Here, the facet-dependent ESAE performance is first evaluated to increase the sluggish hydrogenation kinetics and provide mechanistic insight for subsequent catalyst design. As a result, the Ag nanocubes with {100} surfaces demonstrate a partial current density of 337 mA cm −2 at −1.5 V vs. RHE, greatly outperforming their counterparts with {111} surfaces exposed. Further comparisons of H 2 O splitting and C 2 H 2 hydrogenation reveal that the activation of C 2 H 2 is a crucial factor in promoting the kinetics of ethylene electrosynthesis. Additionally, experimental and theoretical mechanistic characterizations demonstrate that stronger C 2 H 2 adsorption over the {100} surface strengthens the π conjugation of C 2 H 2 , leading to the delocalization of π electrons to promote the activation of C 2 H 2 for enhanced hydrogenation kinetics.}, archive = {J_ANGEW}, author = {Boqiang Miao and Fanpeng Chen and Chuanqi Cheng and Minli Tao and Bo-Hang Zhao and Bin Zhang}, doi = {10.1002/anie.202502757}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502757}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting the kinetics of ethylene electrosynthesis via the facet-dependent activation of acetylene over silver catalysts}, volume = {64}, year = {2025}, }
• (2025). Photogeneration and visualization of a surface-stabilized dinitrene. ANGEW, 64(20), e202502640. (www)

  @article{ , abstract = {Nitrenes are known as key intermediates in various chemical reactions. Nitrene transfer reactions are particularly effective for synthesizing nitrogen-containing compounds, where metal catalysts play a crucial role in controlling nitrene reactivity and selectivity. In this study, we demonstrate the formation of a stable surface-supported dinitrene on Au(111) through UV irradiation of its diazide precursor, characterized by scanning probe techniques. The photoreaction mechanism is elucidated with wavelength-dependent experiments and time-dependent density functional theory calculations. Our findings present the first real-space visualization of a metal nitrene adsorbed on a surface, highlighting its potential in catalysis and surface functionalization.}, archive = {J_ANGEW}, author = {Federico Frezza and Ana Sánchez-Grande and Sofia Canola and Christophe Nacci and Jiří Klívar and Pingo Mutombo and Qifan Chen and José María Gómez-Fernandez and Carlos Sánchez-Sánchez and Jan Berger and Karl-Heinz Ernst and Irena G. Stará and José Ángel Martín-Gago and Ivo Starý and Leonhard Grill and Pavel Jelínek}, doi = {10.1002/anie.202502640}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photogeneration and visualization of a surface-stabilized dinitrene}, volume = {64}, year = {2025}, }
• (2025). Aqueous zinc-bromine battery with highly reversible bromine conversion chemistry. ANGEW, 64(20), e202502386. (www)

  @article{ , abstract = {Br 2 /Br − conversion reaction with a high operating potential (1.85 V vs . Zn 2+ /Zn) is promising for designing high-energy cathodes in aqueous Zn batteries. However, the ultrahigh solubility of polybromides causes significant shuttle effects, capacity deterioration, and self-discharge, rendering the study of static zinc-bromine batteries still in its infancy. Here, various aqueous zinc salt electrolytes are first screened, showing that, compared to other salts, ZnSO 4 is more suitable for Br-based cathodes benefiting from its higher negative charge density and lower cost. Nevertheless, the significant shuttle effect of polybromides remains in such an electrolyte. We further develop a targeted sequestration strategy to fundamentally confine polybromide migration from KBr cathode into electrolyte. In high-mass-loading (22 mg KBr cm −2 ) pouch cells, the average Coulombic efficiency enhances from 92.3 % to 99.8 %, and self-discharge performance dramatically improves from 17.4 % capacity retention to 85.2 % after 72 h of resting, indicating the effectiveness of our strategy in confining the shuttle effects. Furthermore, an Ah-scale pouch cell delivers an average Coulombic efficiency of 99.88 % and a zinc utilization of 22 % at a high rate of 3 C. Our findings also pave the way for the design of advanced Br-based cathodes.}, archive = {J_ANGEW}, author = {Xun Zhao and Junnan Hao and Qianru Chen and Shao-Jian Zhang and Han Wu and Lei Mao and Shi-Zhang Qiao}, doi = {10.1002/anie.202502386}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502386}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aqueous zinc-bromine battery with highly reversible bromine conversion chemistry}, volume = {64}, year = {2025}, }
• (2025). Synthesis of selenium-doped heteroacenes: Unveiling the external heavy-atom effect in host materials. ANGEW, 64(20), e202502380. (www)

  @article{ , abstract = {The internal heavy-atom effect (IHAE) has garnered considerable attention as a promising approach for developing highly efficient emitters in organic light-emitting diodes (OLEDs). Nevertheless, the external heavy-atom effect (EHAE) in host materials, despite being equally important, has been largely overlooked. In this study, we introduce a selenium-doping strategy to unlock the potential of EHAE in host molecules. To demonstrate this approach, we developed a straightforward method for synthesizing structurally diverse pyridine-fused, selenium-containing heteroacenes via an intramolecular radical cyclization of 2-(arylselanyl)pyridin-3-amine derivatives. This method facilitates the rapid construction of a novel host molecule, DCz-BSeP, by incorporating two carbazole groups into the benzo[4,5]selenopheno[2,3- b ]pyridine (BSeP) core. Compared to its oxygen-based (DCz-BFP) and sulfur-based (DCz-BTP) counterparts, the introduction of selenium in DCz-BSeP significantly enhances spin-orbit coupling and accelerates the reverse intersystem crossing rate of thermally activated delayed fluorescence (TADF) emitters by threefold, while also improving bipolar transport properties. These enhancements make DCz-BSeP an ideal bipolar host for high-performance, wide-color-gamut TADF-OLEDs, with notably reduced efficiency roll-off. Additionally, its successful application in phosphorescent OLEDs (Ph-OLEDs) and TADF-sensitized narrowband red fluorescence OLEDs (TSF-OLEDs) highlights its versatility in advancing OLED technologies.}, archive = {J_ANGEW}, author = {Fei Wang and Jinting Ye and Junjie Liu and Xian-Kai Chen and Yudong Yang and Zhengyang Bin and Jingsong You}, doi = {10.1002/anie.202502380}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502380}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of selenium-doped heteroacenes: Unveiling the external heavy-atom effect in host materials}, volume = {64}, year = {2025}, }
• (2025). Dehydrogenative dual ammonia activation and transfer by an N-heterocyclic boryloxy aluminyl compound. ANGEW, 64(20), e202502326. (www)

  @article{ , abstract = {The reactivity of an N-heterocyclic boryloxy (NHBO) ligated aluminyl compound has been harnessed for main-group-mediated dehydrogenative dual activation of ammonia. The Al(I) system K[{(HCDippN) 2 BO} 2 Al] reacts with excess NH 3 to give the Al(III) bis(amide) K[{(HCDippN) 2 BO} 2 Al(NH 2 ) 2 ] and in the process generates H 2 . The initial stage of the reaction proceeds via formal N−H oxidative addition at Al(I) (via a coordination/proton shuttling sequence) to give an aluminium(III) primary amido hydride. Subsequent protonolysis of the strongly hydridic Al−H bond selectively yields the corresponding aluminium bis(amide) and H 2 . This step occurs without competing protolytic ligand loss – exploiting the limited basicity of the supporting [(boryl)O] − donors. In terms of amide transfer reactivity, the utility of K[{(HCDippN) 2 BO} 2 Al(NH 2 ) 2 ] in delivering one or both equivalents of [NH 2 ] − to electrophilic substrates (HBpin, CO 2 and Ph 2 CO) has been demonstrated.}, archive = {J_ANGEW}, author = {Debotra Sarkar and Petra Vasko and Lu Ying and Job J. C. Struijs and Liam P. Griffin and Simon Aldridge}, doi = {10.1002/anie.202502326}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502326}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dehydrogenative dual ammonia activation and transfer by an N-heterocyclic boryloxy aluminyl compound}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of chiral ferrocenyl aminoalcohols: Simultaneous induction of multiple types of chirality by a rhodium-catalyzed asymmetric ring-opening strategy. ANGEW, 64(20), e202502299. (www)

  @article{ , abstract = {Chiral ferrocenyl aminoalcohols were enantioselectively synthesized via the rhodium-catalyzed asymmetric aminative ring-opening of 1,4-epoxy-1,4-dihydronaphthalenylferrocenes. A planar chiral phosphine-olefin ligand consisting of a cyclopentadienyl (Cp) manganese scaffold provided excellent catalytic performance, furnishing the ring-opening products in high yield and enantioselctivity (up to 99 : 1 enantiomeric ratio (e.r.)). The enantioselectivity could be further improved by changing the steric congestion in the cyclopentadienyl unit of the ferrocenyl fragment of the starting 1,4-epoxy-1,4-dihydronaphthalenylferrocene. Density functional theory (DFT) calculations confirmed the high enantioselective induction in the ring-opening reaction, estimating an e.r. of 99 : 1, which is in excellent agreement with the experimental results. The application of the thus obtained chiral ferrocenyl aminoalcohols as ligands in asymmetric reactions was also investigated.}, archive = {J_ANGEW}, author = {Takamu Isoda and Komei Jimba and Kyohei Kawashima and Takahiro Nishinoiri and Seiji Mori and Akihiro Tsurusaki and Ken Kamikawa}, doi = {10.1002/anie.202502299}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502299}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of chiral ferrocenyl aminoalcohols: Simultaneous induction of multiple types of chirality by a rhodium-catalyzed asymmetric ring-opening strategy}, volume = {64}, year = {2025}, }
• (2025). Synthesis of the first isolable geminal 1,1-dilithiostannane and its intriguing structural diversity. ANGEW, 64(20), e202502273. (www)

  @article{ , abstract = {The synthesis of the first isolable geminal 1,1-dilithiostannane is reported. In the solid state, the novel 1,1-dilithiostannane has three different structural motifs, depending on the reaction conditions used for its synthesis: (1) an unsolvated co-aggregate consisting of two 1,1-dilithiostannane molecules and two silyllithium molecules, {[( t Bu 2 MeSi) 2 SnLi 2 ] 2 ⋅ [ t Bu 2 MeSiLi] 2 }; (2) a solvated trimeric stannyllithium dianion {[( t Bu 2 MeSi) 2 Sn] 3 Li 4 } 2− associated with two fully dissociated THF-solvated Li + cations; (3) a THF-solvated contact-ion pair dimer of 1,1-dilithiostannane, [( t Bu 2 MeSi) 2 SnLi 2 ] 2 ⋅ (THF) 4 .}, archive = {J_ANGEW}, author = {Roman Bashkurov and Natalia Fridman and Dmitry Bravo-Zhivotovskii and Yitzhak Apeloig}, doi = {10.1002/anie.202502273}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502273}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of the first isolable geminal 1,1-dilithiostannane and its intriguing structural diversity}, volume = {64}, year = {2025}, }
• (2025). Enhanced water permeation in positively charged water channels: Insights into the molecular mechanism. ANGEW, 64(20), e202502267. (www)

  @article{ , abstract = {The high selectivity and permeability of aquaporin proteins in water transport inspired the design of artificial water channels (AWCs). The water transport efficiency of both AQPs and AWCs is influenced by charged groups at the pore entrance. Here, we explored the mechanism of charge effects in pillar[5]arene AWCs using molecular dynamics (MD) simulations. The simulations demonstrate that the positively charged AWCs ( Ch + ) exhibit higher water permeability compared to the negatively charged AWCs ( Ch − ). The higher permeability of Ch + channels stems from the shorter hydrogen bond lifetimes between water molecules at the entrance region. In line with this, the rotational dynamics of water is faster in the entrance region of Ch + . Further analyses revealed two factors contributing to the distinct water dynamics in Ch + and Ch − channels: the direct interactions of the NH 3 + /COO − groups with water and the counter ions (Cl − /K + ) around these charged groups. NH 3 + groups in Ch + channels exert less stable H-bond interaction with water than the COO − group in Ch − channels. K + ions concentrated around the COO − groups retard the water rotation more effectively than the Cl − ions around the NH 3 + groups. These findings provide insights into the design principles of high-performance AWCs at the molecular level.}, archive = {J_ANGEW}, author = {Yinglan Wang and Jun-Li Hou and Wenning Wang}, doi = {10.1002/anie.202502267}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502267}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced water permeation in positively charged water channels: Insights into the molecular mechanism}, volume = {64}, year = {2025}, }
• (2025). Niobium phosphide-induced sulfur cathode interface with fast lithium-ion flux enables highly stable Lithium–Sulfur catalytic conversion. ANGEW, 64(20), e202502255. (www)

  @article{ , abstract = {Research on the Li−S catalytic chemistry primarily focus on the development of high-performance catalysts and the exploration of their reaction mechanisms, with limited attention given to the impact on the interface at the cathode. Moreover, regulating the Li + flux at the cathode interface can enhance Li 2 S conversion kinetics without compromising the intrinsic catalytic activity of catalyst. This work presents a paradigm that employs interface regulation to enhance Li−S battery (LSB) cycling stability. A novel phosphorus doped carbon supported niobium phosphide nanocrystals (NbP/PC) catalyst is developed and demonstrates exceptional intrinsic activity for lithium polysulfide conversion while it facilitates lithium salt dissociation through intermolecular hybridization. The NbP-induced functional interface layer with abundant LiF and Li 3 N provides efficient Li + transport channel for Li 2 S decomposition, which further mitigates the passivation of active sites. In consequence, the assembled LSB exhibits a capacity retention rate of 0.04 % per cycle after 1100 cycles at a 1 C. Furthermore, the pouch battery with an energy density of 451 Wh kg −1 maintains stable performance over 20 cycles. This strategy addresses the limitations of traditional catalytic material design in the chemical regulation of the cathodic interface for promising future of LSBs.}, archive = {J_ANGEW}, author = {Peng Wang and Hongyu Mou and Yu Wang and Ning Song and Xiaogang Li and Jinkui Feng and Baojuan Xi and Shenglin Xiong}, doi = {10.1002/anie.202502255}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502255}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Niobium phosphide-induced sulfur cathode interface with fast lithium-ion flux enables highly stable Lithium–Sulfur catalytic conversion}, volume = {64}, year = {2025}, }
• (2025). Co nanoparticle: An efficient H-pump for pt single atoms towards enhanced hydrogen spillover. ANGEW, 64(20), e202502227. (www)

  @article{ , abstract = {Introducing OH-interaction sites to accelerate water dissociation can increase hydrogen coverage on active site surfaces and thus accelerate H-spillover, leading to an enhanced hydrogen evolution reaction (HER). Recent studies on single-atom catalysts (SACs) combined with nano-metal-particles (NMPs) have developed various homologous NMP-SACs, however, synthesizing the heterologous NMP-SACs remains a significant challenge. Particularly for HER catalysts under alkaline conditions, the ideal heterologous structure requires a synergy between non-noble NMPs with strong oxophilicity and noble-metal SAs with suitable hydrogen binding energy. Herein, we report a facile pyrolysis-confinement strategy to create the heterologous NMP-SACs, comprising Co NMP (Co n ) and Pt SACs (Pt 1 ) confined within N-doped hollow polyhedral carbons (Co n -Pt 1 @NPC). This catalyst demonstrates outstanding HER activity and superior stability in alkaline electrolyzer. Calculations reveal that Co nanoparticles serve as an H-pump, dissociating water to supply hydrogen to Pt 1 sites, thereby enhancing the HER through a short C site→C−Pt bridge site→Pt site hydrogen spillover pathway.}, archive = {J_ANGEW}, author = {Yike Xu and Junyi Du and Jingyun Jiang and Yumin Miao and Zechao Zhuang and Zhenyu Liu and Yuanyuan Yan and Rongrong Pan and Jin Yang and Meiling Wang and Shaonan Gu and Lixing Kang and Dingsheng Wang}, doi = {10.1002/anie.202502227}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502227}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Co nanoparticle: An efficient H-pump for pt single atoms towards enhanced hydrogen spillover}, volume = {64}, year = {2025}, }
• (2025). Mussel foot protein membrane-enclosed crystalline drug with zero-order release kinetics for long-acting therapy. ANGEW, 64(20), e202502205. (www)

  @article{ , abstract = {Injectable formulations with sustained and steady release capabilities are critically required to treat diseases requiring temporary or lifelong continuous therapy, especially for drugs with a short half-life. Additionally, achieving a sufficiently high drug loading in a single dose remains a persistent challenge. Herein, by mimicking the formation principles of mussel adhesive plaques, we have developed membrane-enclosed crystalline systems of insulin and progesterone as model macro- and small-molecular crystalline drugs. The system exhibits a substantial drug loading capacity (>90 %). It exhibits sustained and zero-order release kinetics, thereby facilitating the establishment of a subcutaneous reservoir containing a substantial drug load, enabling progressive and continuous release of the drug into the body. One single injection of membrane-enclosed insulin crystal can maintain normoglycemia in diabetic mice for up to 7 days. Meanwhile, membrane-coated progesterone crystals can sustain drug release in rats for over 7 days. The protein membrane can be cleared from the injection sites in 35 days. This system can serve as a versatile platform for the sustained release of various crystalline pharmaceuticals and the treatment of distinct diseases.}, archive = {J_ANGEW}, author = {Leihao Lu and Jianchang Xu and Xuehui Huang and Leyi Hu and Kangfan Ji and Chuhuan Jiang and Yanfang Wang and Yue Qin and Yang Zhang and Juan Zhang and Jiahao Hu and Shenxi Qian and Yingqi Huang and Hongzhen Bai and Xiangnan Zhang and Fuyao Liu and Zhen Gu and Jinqiang Wang}, doi = {10.1002/anie.202502205}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502205}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mussel foot protein membrane-enclosed crystalline drug with zero-order release kinetics for long-acting therapy}, volume = {64}, year = {2025}, }
• (2025). Dynamic short hydrogen-bonding network enhancing hydrophilicity in biomimetic membranes with artificial water channels for efficient removal of dyes and salts. ANGEW, 64(20), e202502204. (www)

  @article{ , abstract = {The development of an integrated biomimetic membrane capable of rejecting both dyes and salts in a single step, while sustaining stable water permeation, presents a promising solution for textile wastewater treatment. Herein, we report a novel integrated biomimetic membrane integrating an I-quartet artificial water channel (AWC) with sulfonic acid-modified polyamide (PA-SO 3 H), which can stably reject both dyes and inorganic salts. The I-quartet channels (2.68 Å), formed via self-assembly of alkyl-ureido-ethyl-imidazole (HC8) molecules, facilitate selective water transport and rejection of both dyes and inorganic salts. Concurrently, the sulfonic acid groups (−SO 3 H) could grab water molecules, forming dynamic short hydrogen-bonding network (O−H⋅⋅⋅O). These hydrogen bonds not only serve as jumping force, lowering the energy barrier for water transport through the alternating hydrophilic-hydrophobic matrix, but also act as an effective antifouling barrier, significantly reducing membrane fouling. The optimal HC8 3.0 -PA-SO 3 H membrane exhibits a water permeance of 13.4 L m -2 h -1 MPa -1 , approximately 2.7-fold higher than that of the pristine PA membrane, and both high dyes and salts rejection efficiency. Moreover, the membrane sustains stable antifouling characteristics throughout a 19-day endurance test. This innovative membrane design provides a promising solution for the efficient separation of both dyes and inorganic salts in textile wastewater treatment.}, archive = {J_ANGEW}, author = {Wenmin Wang and Yun Jin and Xiuxia Meng and Naitao Yang and Xuefeng Zhu}, doi = {10.1002/anie.202502204}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502204}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic short hydrogen-bonding network enhancing hydrophilicity in biomimetic membranes with artificial water channels for efficient removal of dyes and salts}, volume = {64}, year = {2025}, }
• (2025). A druglike ferrostatin-1 analogue as a ferroptosis inhibitor and photoluminescent indicator. ANGEW, 64(20), e202502195. (www)

  @article{ , abstract = {Redox-based diagnostic and therapeutic applications have long suffered from a shortage of suitable drugs and probes of high specificity. In the context of anti-ferroptosis research for neurological diseases, the inaccessibility of a blood–brain barrier (BBB) permeable small molecular ferroptosis inhibitor, and the lack of specific ferroptosis probes, seriously impeded a deeper understanding of the mechanism of ferroptosis and the development of clinically applicable drugs. We report herein a novel 1,3,4-thiadiazole-functionalized druglike ferrostatin analogue entitled Ferfluor-1 with superior anti-ferroptosis potency, favorable BBB permeability and in vivo activity against stroke and Parkinson's disease. Moreover, the exclusive pseudo-excited-state intramolecular proton-transfer (ESIPT) property of Ferfluor-1 via a long-distance hydrogen-bonding network makes it the first sensitive ratiometric photoluminescent probe to detect phospholipid hydroperoxides and a specific indicator for the fluctuation of ferroptosis. These unprecedented advantages not only make Ferfluor-1 a potential tool for ferroptosis-related diagnostic and therapeutic applications in the central nervous system, but also pave the way to developing new theragnostic agents for precision redox detection and regulation.}, archive = {J_ANGEW}, author = {Jiangkun Yan and Luo Bao and Huicong Liang and Li Zhao and Ming Liu and Lingxiu Kong and Xuejing Fan and Chunhui Liang and Tongtong Liu and Xinyu Han and Kangnan Wang and Chuanbin Shen and Wanyang Sun and Xin Zhou and Bo Chu and Michael J. McGlinchey and Ximing Xu and Xue Qiu and Yong Wang}, doi = {10.1002/anie.202502195}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502195}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A druglike ferrostatin-1 analogue as a ferroptosis inhibitor and photoluminescent indicator}, volume = {64}, year = {2025}, }
• (2025). Electrochemical responsive alginate chains rendered sol-to-gel gradient electrolyte towards practical ah-level zinc metal pouch cell. ANGEW, 64(20), e202502103. (www)

  @article{ , abstract = {Zinc metal batteries have been considered as an appealing candidate for grid-scale energy storage devices, but are hindered by the instable interface. Herein, we design a sol-to-gel gradient electrolyte through the simultaneous electrochemical deposition of Zn 2+ and alginate. The electrochemical gelation of alginate creates a gradient sol-to-gel interface and enables the high ionic conductivity, where vehicular mechanism dominated transport is maintained in the bulk electrolyte, while a lean-water hydrogel like state is created at the Zn/electrolyte interface to reduce water activity. The electrochemical active alginate undergoes a gelation process to form an egg-shell to confine the Zn 2+ , rendering a 2D growth mode and inhibiting dendrite growth. By taking the advantages of both fast ion transport and stable interface, the full cell based on Zn/VO 2 achieved a stable cycling of 400 cycles at an industrial-level areal capacity of over 4 mAh cm −2 with a capacity retention of 89.25 %. Additionally, we demonstrate the Ah-level pouch cell, which stably operates for over 200 cycles with an almost unity average coulombic efficiency (over 99.90 %). By demonstrating the remarkable performance, our work represents an advancement in zinc metal batteries toward a practical scale and is expected to set a stepping stone for transformative advancements in energy storage technologies.}, archive = {J_ANGEW}, author = {Liheng Zheng and Linhui Chang and Shiyan Xue and Kangning Zhao and Bomian Zhang and Weidong He and Feng Tao and Jinghao Li and Min Wang and Qinyou An and Lei Zhang}, doi = {10.1002/anie.202502103}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502103}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical responsive alginate chains rendered sol-to-gel gradient electrolyte towards practical ah-level zinc metal pouch cell}, volume = {64}, year = {2025}, }
• (2025). A trimming-π strategy for constructing functional conductive Metal–Organic frameworks using metalloporphyrazine units. ANGEW, 64(20), e202502066. (www)

  @article{ , abstract = {Developing functional metal–organic frameworks (MOFs) with high electrical conductivity is crucial for their applications as advanced electronic materials. In this work, we for the first time construct a new family of functional and highly conductive MOFs using metalloporphyrazine (MPz) ligands based on a trimming-π concept via cutting the benzene ring from molecular metallopthalocynine (MPc). The deprotonation-after-coordination synthetic method affords crystalline MPz−Cu−NH MOFs with square lattices. Four-point probe conductivity measurements reveal the high room temperature electrical conductivity of MPz-based MOFs ranging from 3.5×10 −2 to 1.3×10 −1 S cm −1 , two orders of magnitude higher than the MPc-based MOF counterparts. Temperature-dependent conductivity measurements and electronic band structure analysis demonstrate ultra-small activation energies with potential metallic conducting behavior for the MPz−Cu−NH MOFs. Encapsulation of the aromatic guest molecules with different electron-donating and -withdrawing features allows the conductivity modulation of the CuPz−Cu−NH in a wide range spanning two orders of magnitude. These conductive MPz−Cu−NH MOFs with built-in MPz functional units exhibit MPz identity-dependent sensing performance, and realize highly sensitive detection of NH 3 and NO 2 using a low driving voltage of 0.1 V.}, archive = {J_ANGEW}, author = {Junqiang Jiao and Mingyu Yang and Xiangxin Ye and Yi Zhang and Yi Jiang and Zheng Meng}, doi = {10.1002/anie.202502066}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202502066}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A trimming-π strategy for constructing functional conductive Metal–Organic frameworks using metalloporphyrazine units}, volume = {64}, year = {2025}, }
• (2025). Luminescent alkylaluminium anthranilates reaching unity quantum yield in the condensed phase. ANGEW, 64(20), e202501985. (www)

  @article{ , abstract = {Transition, post-transition and rare earth metal complexes supported by (O,N) - and (N,N) -type ligands dominate organometallic photochemistry. However, despite a vast number of aminobenzoate metal complexes having been reported, and aluminium being globally abundant, alkylaluminium anthranilates have not yet been considered as effective luminophores. Herein, using a family of commercially available ligands composed of anthranilic acid ( anth -H 2 ) and its N -substituted derivatives, we report the isolation and characterisation of a series of unique tetrameric chiral-at-metal alkylaluminium anthranilates, [(R'- anth )AlR] 4 . The resulting compounds are characterised using spectroscopic methods and single-crystal X-ray diffraction to analyse structure-determining factors in the solid state and solution. Moreover, by changing the N -substituents from H to Me and Ph, we have yielded a series of luminophores that exhibit poor-to-excellent performance, providing a [(Ph- anth )AlEt] 4 derivative that achieves a unity photoluminescence quantum yield in the condensed phase, which is unprecedented for aluminium complexes.}, archive = {J_ANGEW}, author = {Vadim Szejko and Iwona Justyniak and Maria Jędrzejewska and Grzegorz Jędrzejczyk and Thea-Luise Precht and Adam Kubas and Andrew E. H. Wheatley and Janusz Lewiński}, doi = {10.1002/anie.202501985}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501985}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Luminescent alkylaluminium anthranilates reaching unity quantum yield in the condensed phase}, volume = {64}, year = {2025}, }
• (2025). One-step directed self-assembly of molecular closed four-link chains and borromean links. ANGEW, 64(20), e202501965. (www)

  @article{ , abstract = {Despite substantial advancements in the synthesis of mechanically interlocked molecules (MIMs), the efficient construction of higher order links remains a formidable challenge. Herein, we report the highly efficient one-step directed construction of a series of unprecedented molecular closed four-link chains (84 1 metalla-links), achieved through the synergistic assembly of coordination-driven and aromatic stacking interactions involving binuclear rhodium/iridium precursors and bis-dentate benzothiadiazole derivative ligands. Meanwhile, modulating the substituent positions of the pyridine groups in the ligand resulted in a change in topological structure, leading to the formation of two molecular Borromean links ( metalla-links). The molecular configurations of the abovementioned metalla-links were clearly identified through mass spectrometry, NMR, and single-crystal X-ray diffraction. Furthermore, structural transformation between the molecular Borromean links and corresponding monocycles was achieved through concentration effects, as validated by solution-state NMR spectroscopy investigations.}, archive = {J_ANGEW}, author = {Wei-Long Shan and Nian Si and Meng-Ting Xu and Zhi-Yang Chen and Gen Zhao and Haitong Tang and Guo-Xin Jin}, doi = {10.1002/anie.202501965}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501965}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-step directed self-assembly of molecular closed four-link chains and borromean links}, volume = {64}, year = {2025}, }
• (2025). Pure hydrocarbon hosts enabling efficient multi-resonance TADF blue-emitting organic light-emitting diodes. ANGEW, 64(20), e202501895. (www)

  @article{ , abstract = {Pure hydrocarbon (PHC) materials are a class of highly efficient and stable host materials for organic light-emitting diodes (OLEDs), composed solely of carbon and hydrogen atoms. Despite recent great advancements in PHC research, their applications are still mainly limited to phosphorescent OLEDs (PHOLEDs). High-performance blue OLEDs still pose a considerable challenge. Thus, expanding PHC materials into other types of OLEDs is critical for advancing organic electronic technologies. In this study, we designed a series of original high-triplet PHC materials based on a multi-substitution approach of the 9,9′-spirobifluorene (SBF) backbone and used them, for the first time, as a host in phosphorescence-sensitized multi-resonance thermally activated delayed fluorescence (MR-TADF) OLEDs. Devices based on the 2,6-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)boron (DtBuCzB) emitter, using FIrpic or fac-Ir(tpz) 3 as the sensitizer, achieved high maximum external quantum efficiency (EQE max ) values ranging from 29.1 % to 33.9 %. Additionally, blue MR-TADF OLED devices based on v -DABNA with a phosphorescent sensitizer (CN−Ir), demonstrated outstanding electroluminescent performance, with an EQE max of approximately 31 % due to an excellent molecular orientation induced by the PHC hosts. All devices exhibited narrow full-width at half-maximum spectra and minimal efficiency roll-off. This study marks the first application of PHC materials as hosts in phosphorescence-sensitized MR-TADF OLEDs, highlighting their potential as promising candidates for next-generation blue OLEDs and offering a viable pathway to achieve high-performance devices.}, archive = {J_ANGEW}, author = {Yue-Jian Yang and Denis Ari and Zhe-Hong Yu and Kelvine Letellier and Olivier Jeannin and Qi Zheng and Aziz Khan and Cassandre Quinton and Dong-Ying Zhou and Zuo-Quan Jiang and Cyril Poriel}, doi = {10.1002/anie.202501895}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501895}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pure hydrocarbon hosts enabling efficient multi-resonance TADF blue-emitting organic light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Superhelical self-assembly of microcrystals from cyclodipeptides. ANGEW, 64(20), e202501832. (www)

  @article{ , abstract = {Expression of chirality at macroscopic scale through solution-processed bottom-up assembly is accompanied by the formation of complex superstructures. It undergoes complicated pathway including the hierarchical organization of molecular blocks in a spontaneous and ordered manner. Here we present a cyclodipeptide platform which delicately expresses chirality at the macroscopic level. Homochiral linear dipeptides bearing tyrosine and phenylglycine residue go through cyclization to afford cyclodipeptides, leading to the in situ reaction-induced aggregation into giant helices with ultra-high yields and phase purity. The pathway comprises formation of subunit microcrystals and the subsequent assembly through adhesion of favorable planes. The cyclodipeptide adopts a folded geometry that generates 2D hydrogen bonded networks differing from the typical 1D duplex hydrogen bonding of diketopiperazines skeletons. The assembly of subunit crystals driven by the hydrogen bonding undergoes dislocations mediated by the inherent chirality of cyclodipeptides. The bulky helices perform as matrices to accommodate cargoes to realize full spectrum luminescent colors with efficient chirality transfer and strong circularly polarized luminescence.}, archive = {J_ANGEW}, author = {Zhuoer Wang and Yitong Gai and Aiyou Hao and Pengyao Xing}, doi = {10.1002/anie.202501832}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501832}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Superhelical self-assembly of microcrystals from cyclodipeptides}, volume = {64}, year = {2025}, }
• (2025). Volatile imide additives with large dipole and special film formation kinetics enable high-performance organic solar cells. ANGEW, 64(20), e202501816. (www)

  @article{ , abstract = {Large dipole moment additives have strong interactions with the host materials, which can optimize morphology and improve the photovoltaic performance of organic solar cells (OSCs). However, these additives are difficult to remove due to their strong intermolecular interactions, which may impair stability. Developing volatile additives with large dipole moments is challenging. Herein, we first report volatile imide additives that could effectively improve the performance of OSCs through morphology modification. Three additives N -( o -chlorophenyl)phthalimide ( o ClPA), N -( m -chlorophenyl)phthalimide ( m ClPA), and N -( p -chlorophenyl)phthalimide ( p ClPA) were screened to investigate the effort of positional isomerization on molecular configuration and interaction. These additives (ClPAs) have larger dipole moments (2.0664 Debye for o ClPA, 4.2361 Debye for m ClPA, and 4.7896 Debye for p ClPA) compared to reported solid additives. In contrast to traditional simultaneous nucleation and crystal growth, ClPAs could induce the acceptor to nucleate first and then grow, which contributes to forming high-quality acceptor domains with better crystallinity. To our knowledge, this unique film formation kinetics was reported first. The power conversion efficiency (PCE) of OSCs based on PM6:BTP-eC9 treated with p ClPA was improved from 16.13 % to 18.58 %. Additive p ClPA also performed well in PM6:L8-BO, PM6:Y6, and D18:L8-BO systems, and a high PCE of 19.04 % was achieved. Our results indicate using imide unit to construct solid additives is a simple and effective strategy, and the positional isomerization of halogen atom also has a large effect on the photovoltaic performance.}, archive = {J_ANGEW}, author = {Shuangshuang Xia and Jie Xu and Zongtao Wang and Seunglok Lee and Lei Wang and Yu Hu and Xiaohong Zhao and Changduk Yang and Erjun Zhou and Zhongyi Yuan}, doi = {10.1002/anie.202501816}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501816}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Volatile imide additives with large dipole and special film formation kinetics enable high-performance organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Re and ru co-doped transition metal alloy as a bifunctional catalyst for electrooxidation of glycerol to formate coupled with h2 production. ANGEW, 64(20), e202501766. (www)

  @article{ , abstract = {Glycerol electrooxidation (GOR), as an innovative strategy for the production of value-added chemicals, is considered a promising anodic alternative to oxygen evolution reaction in electrocatalysis. However, the high potential and the limited selectivity and faradaic efficiency impede the industrial-scale application toward GOR. Herein, we for the first time constructed rhenium and ruthenium co-doped transition metal alloy (NiCoFeRuRe) for the efficient electrooxidation of glycerol to formate. Benefiting from the rapid generation of M 3+ -OOH induced by Ru element and the inhibition of OER and excessive oxidation of glycerol by Re species through in situ chacterization, the optimized NiCoFeRuRe requires only 1.133 V RHE to achieve a current density of 10 mA cm −2 , a faradaic efficiency of 95.6 % for formate product with a stability more than 450 h. Importantly, employing NiCoFeRuRe as a bifunctional catalyst, the cell is constructed to produce hydrogen and formate simultaneously, which is 265 mV lower than the electrolytic water splitting owning an excellent stability of 350 h. This work provides a facile strategy for rationally designing high-performance GOR catalysts for biomass upgradings.}, archive = {J_ANGEW}, author = {Hengyi Chen and Rui-Ting Gao and Kerong Su and Zilong Li and Limin Wu and Lei Wang}, doi = {10.1002/anie.202501766}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501766}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Re and ru co-doped transition metal alloy as a bifunctional catalyst for electrooxidation of glycerol to formate coupled with h2 production}, volume = {64}, year = {2025}, }
• (2025). Manipulating crystal packing in heterocycloarenes by an atom engineering strategy for high-mobility organic field-effect transistors. ANGEW, 64(20), e202501686. (www)

  @article{ , abstract = {Developing (hetero)cycloarenes, an emerging class of ring-shaped organic semiconductors (OSCs), for high-performance optoelectronic applications remains significantly constrained due to their synthetic challenge and limited diversity of available materials. Herein, a series of coplanar chalcogen-fused heterocycloarenes NO , NS , and NSe with long branched alkyl chains were synthesized in single-crystal form, and chalcogen atom engineering on heterocycloarenes was investigated in detailed. Sulfur-fused NS exhibits a closest herringbone crystal packing with π–π stacking distance as low as 3.11 Å, resulting in a record-high hole mobility of 3.13 cm 2 V −1 s −1 among all reported ring-shaped OSCs. Remarkably, selenium-fused NSe without intermolecular π–π interactions in its crystalline state, also manifests the second highest mobility of up to 2.11 cm 2 V −1 s −1 , which is attributed to the presence of extensive short-range edge-to-face Se…π and C−H…π interactions. Furthermore, these heterocycloarenes exhibit a selective supramolecular interaction with C 70 , with the trend in binding constants being: NS < NO < NSe . Overall, this work not only systematically elucidates the role of atom engineering on heterocycloarenes for the first time, but also paves the way for practical applications of the emerging ring-shaped OSC materials.}, archive = {J_ANGEW}, author = {Rong Zhang and Wenhao Li and Yuanhe Gu and Teng Wang and Jiaxi Zhang and Kai Chi and Yunqi Liu and Xuefeng Lu and Yan Zhao}, doi = {10.1002/anie.202501686}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501686}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating crystal packing in heterocycloarenes by an atom engineering strategy for high-mobility organic field-effect transistors}, volume = {64}, year = {2025}, }
• (2025). Borohydride oxidation as counter reaction in reductive electrosynthesis. ANGEW, 64(20), e202501653. (www)

  @article{ , abstract = {An efficient reaction at the counter electrode is of key importance for the success of net oxidative and net reductive electrochemical transformations. For electrooxidative processes, cathodic proton reduction to H 2 serves as the benchmark counter reaction. In contrast, net reductive electrochemical transformations have less attractive oxidative counter reactions to choose from and commonly rely on dissolution of a sacrificial anode that effectively results in stoichiometric metal consumption for the processes. In this study, we demonstrate that anodic borohydride oxidation has great potential to successfully replace the use of such sacrificial anodes for a variety of electroreductive organic transformations. This anodic transformation effectively serves as the inverse of cathodic proton reduction, producing H 2 using inert carbon-based electrode materials.}, archive = {J_ANGEW}, author = {Julius Kuzmin and Malin Lill and Guillermo Ahumada and Ellymay Goossens and Astrid Kjær Steffensen and Anders Riisager and Helena Lundberg}, doi = {10.1002/anie.202501653}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501653}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Borohydride oxidation as counter reaction in reductive electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). From holodirected to hemidirected coordination activated by oxygenation strategy: A facile route to long wave infrared birefringent crystal. ANGEW, 64(20), e202501481. (www)

  @article{ , abstract = {Long wave infrared (LWIR) birefringent crystals are essential for infrared optical applications but such materials are rarely reported due to the requirements of large birefringence and wide infrared transmission range. This study proposes a facile route to create new LWIR birefringent crystal by oxygenation strategy in halides with cations containing lone pair electrons. Given the tendency of such cations to form holodirected geometry, a divalent oxygen was introduced to substitute the monovalent halogen to decrease the coordination number and activate the lone pair electrons. Our efforts in Rb + -Sb 3+ -Cl − system result three new structures, namely, Rb 13 Sb 8 Cl 37 , Rb 3 Sb 2 OCl 7 and Rb 2 Sb 2 OCl 6 . The holodirected SbCl 6 in Rb 13 Sb 8 Cl 37 has been successfully translated to hemidirected SbOCl 4 in Rb 3 Sb 2 OCl 7 and Rb 2 Sb 2 OCl 6 , which are the first examples in alkali metal antimony(III) oxyhalides. The birefringence of Rb 2 Sb 2 OCl 6 reached to 0.191@550 nm, which is 11.2 times that of Rb 13 Sb 8 Cl 37 (0.017@550 nm). Large-sized crystal of Rb 2 Sb 2 OCl 6 have been successfully grown (6×6×2 mm 3 ). It can exhibit good transmission performance in the range of 0.4–13.5 μm, indicating its potential as a promising LWIR birefringent crystal. Our research not only opens up a new material system – alkali metal antimony(III) oxyhalides, but also provides a new strategy to create LWIR birefringent crystals.}, archive = {J_ANGEW}, author = {Xin-Yang Li and Xiyue Cheng and Chun-Li Hu and Bing-Xuan Li and Zhengyang Zhou and Jian-Han Zhang and Shuiquan Deng and Jiang-Gao Mao and Fang Kong}, doi = {10.1002/anie.202501481}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501481}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From holodirected to hemidirected coordination activated by oxygenation strategy: A facile route to long wave infrared birefringent crystal}, volume = {64}, year = {2025}, }
• (2025). Sequence similarity network guided discovery of a dehydrogenase for asymmetric carbonyl dehydrogenation. ANGEW, 64(20), e202501425. (www)

  @article{ , abstract = {Carbonyl dehydrogenation is one of the most valuable transformations in modern synthetic chemistry. As compared to traditional chemical synthesis methods, enzymatic dehydrogenation offers a greener and more selective alternative. However, except for a few rare natural dehydrogenases for desaturation, current enzymatic methods predominantly rely on enzyme promiscuity, which often suffers from lower efficiency and limited reaction controllability. Herein, we employed sequence similarity networks to mine natural dehydrogenases from a vast array of sequences with potential dehydrogenation activity. This approach led to the discovery of an uncharacterized FAD-dependent enzyme capable of efficiently performing the desymmetrizing desaturation of cyclohexanones, thereby generating diverse cyclohexenones bearing remote γ-quaternary stereocenters. The current method has enhanced the turnover frequency (TOF) by approximately 178-fold as compared to the best existing biocatalytic strategies and displayed almost no overoxidation reactions. Through a combination of experimental assays and computational studies, we elucidated that this enzyme enhances its dehydrogenation capability through an unconventional proton relay system, absent in previously reported enzyme promiscuity systems. Additionally, this streamlined enzymatic process demonstrated scalability to gram-scale synthesis with maintained efficiency and selectivity, offering robust and sustainable alternatives for the synthesis of chiral cyclohexenones with high optical purity.}, archive = {J_ANGEW}, author = {Yujing Hu and Jie Chen and Shaofang Qi and Hui Wang and Zhaoxuan Zhu and Yongzhen Peng and Wenjing Wang and Guixiang Huang and Zheng Fang and Yuxuan Ye and Zhiguo Wang and Kai Guo}, doi = {10.1002/anie.202501425}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501425}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sequence similarity network guided discovery of a dehydrogenase for asymmetric carbonyl dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Lithium anionic dicarbenes or acetylides: What is in the name?. ANGEW, 64(20), e202501068. (www)

  @article{ , abstract = {The two-fold deprotonation of the C2-arylated 1,3-imidazolium salts (IPr-Ar)X ( 1 -Ar)X (IPr-Ar = ArC{N(Dipp)CH} 2 ; Ar = Ph, 4-Me 2 NC 6 H 4 (DMP) or 4-PhC 6 H 4 (Bp); Dipp = 2,6- i Pr 2 C 6 H 3 ) with n BuLi affords the so-called anionic dicarbenes Li(ADC) ( 2 -Ar) (ADC = ArC{N(Dipp)C} 2 ). 2 -Ar can be used to prepare a variety of main group heterocycles, however their structures in the solid-state remained hitherto unknown. Herein reported single-crystal X-ray diffraction studies reveal an acetylide type [ArC{N(Dipp)}(Dipp)NC≡CLi)] n ( 3 -Ar) dimeric ( n = 2) or trimeric ( n = 3) molecular structure for 2 -Ar. Treatment of 3 -Ph with Et 3 B cleanly yields the monoanionic carbene Li[(ADC)(BEt 3 )] ( 4 -Ph) featuring a weakly coordinating anion embedded in the same molecular entity. 3 -Ar readily undergo reactions with CO 2 and N 2 O to form the ring-closing products Li[(ADC)(CO 2 ) 2 ] ( 5 -Ar) and Li[(ADC)N 2 O] ( 6 -Ar), respectively.}, archive = {J_ANGEW}, author = {Arne Merschel and Henric Steffenfauseweh and Yury V. Vishnevskiy and Beate Neumann and Hans-Georg Stammler and Rajendra S. Ghadwal}, doi = {10.1002/anie.202501068}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501068}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lithium anionic dicarbenes or acetylides: What is in the name?}, volume = {64}, year = {2025}, }
• (2025). Host-guest chemistry in a capillary applied to the facilitation of the crystalline sponge method. ANGEW, 64(20), e202501025. (www)

  @article{ , abstract = {Capillary is a handy tool for transferring, mixing, and storing small volumes of liquid. Here, we show that the stepwise dipping of host and guest solutions into a capillary allows efficient preparation, crystallization, and X-ray analysis of various host–guest complexes. The crystals formed in capillaries are comparable in quality to those grown in regular flasks and subjected to X-ray analysis without being removed from the capillary. We further apply the capillary technique to the crystalline sponge method, a practical domain of host–guest chemistry, successfully overcoming several technical issues.}, archive = {J_ANGEW}, author = {Wei He and Hiroki Takezawa and Ryo Yakushiji and Satoshi Yoshida and Sota Sato and Makoto Fujita}, doi = {10.1002/anie.202501025}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202501025}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Host-guest chemistry in a capillary applied to the facilitation of the crystalline sponge method}, volume = {64}, year = {2025}, }
• (2025). Nucleation engineering to strengthen interface contacts in single-crystal perovskite photovoltaics. ANGEW, 64(20), e202500947. (www)

  @article{ , abstract = {Perovskite solar cells (PSCs) based on single crystals hold potential for higher efficiency and stability, while the incomplete interface contact hinders hole carrier extraction and device performance. Herein, we report strengthening crystal/substrate contact by nucleation engineering based on in situ growth strategy. Through modulating the hole transport layer (HTL) to induce the nucleation process at substrate surface, interface residual solution, voids, and small-sized crystals are eliminated, thus ensuring intimate interface contact physically. Combining with strong interaction between perovskites and HTL, balanced electron/hole carrier extraction and suppressed nonradiative recombination are achieved. As a result, an impressive power conversion efficiency (PCE) of 25.8 % is obtained, setting a new efficiency benchmark for single-crystal PSCs. Moreover, the thermal-induced peeling-off of crystals from substrates is mitigated, which improves the device thermal stability distinctly.}, archive = {J_ANGEW}, author = {Nianqiao Liu and Mingxun Liu and Jitao Dai and Xiao Cheng and Zhaolai Chen}, doi = {10.1002/anie.202500947}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500947}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nucleation engineering to strengthen interface contacts in single-crystal perovskite photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Enzyme controlled transient phospholipid vesicles for regulated cargo release. ANGEW, 64(20), e202500824. (www)

  @article{ , abstract = {Metabolism in biological systems involves the continuous formation and breakdown of chemical and structural components, driven by chemical energy. In specific, metabolic processes on cellular membranes result in in situ formation and degradation of the constituent phospholipid molecules, by consuming fuel, to dynamically regulate the properties. Synthetic analogs of such chemically fueled phospholipid vesicles have been challenging. Here we report a bio-inspired approach for the in situ formation of phospholipids, from water soluble precursors, and their fuel driven self-assembly into vesicles. We show that the kinetic competition between anabolic and catabolic-like reactions leads to the formation and enzymatic degradation of the double-tailed, vesicle-forming phospholipid. Spectroscopic and microscopic analysis demonstrate the formation of transient vesicles whose lifetime can be easily tuned from minutes to hours. Importantly, our design results in the formation of uniform sized (65 nm) vesicles simply by mixing the precursors, thus avoiding the traditional complex methods. Finally, our sub-100 nm vesicles are of the right size for application in drug delivery. We have demonstrated that the release kinetics of the incorporated cargo molecules can be dynamically regulated for potential applications in adaptive nanomedicine.}, archive = {J_ANGEW}, author = {Akhil Venugopal and Subhadip Ghosh and Annalisa Calò and Gian Marco Tuveri and Giuseppe Battaglia and Mohit Kumar}, doi = {10.1002/anie.202500824}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500824}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzyme controlled transient phospholipid vesicles for regulated cargo release}, volume = {64}, year = {2025}, }
• (2025). Three-electron uric acid oxidation via interdistance-dependent switching pathways in correlated single-atom catalysts for boosting sensing signals. ANGEW, 64(20), e202500474. (www)

  @article{ , abstract = {The overly simplistic geometric and electronic structures of single-atom catalysts have become a significant bottleneck in the field of single-atom sensing, impeding both the design of highly efficient electrochemical sensors and the establishment of structure–activity relationships. To address these challenges, we present a novel strategy to boost the sensing performance of single-atom catalysts by precisely tuning the single-atomic interdistance (SAD) in correlated single-atom catalysts ( c -SACs). A series of Ru-based c -SACs (Ru d =6.2 Å , Ru d =7.0 Å , and Ru d =9.3 Å ) are synthesized with predetermined SAD values, which are comprehensively characterized by various techniques. Electrochemical studies on uric acid (UA) oxidation reveal that Ru d =6.2 Å demonstrates an extraordinary sensitivity of 9.83 μA μM −1 cm −2 , which is superior to most of electrochemistry biosensors reported previously. Kinetic analysis and product examination unveil that the 6.2 Å Ru SAD instigates a distinctive three-electron oxidation of UA, with an extra electron transfer compared to the conventional two-electron pathway, which fundamentally enhances its sensitivity. Density functional theory calculations confirm the optimal SAD facilitates dual-site UA adsorption and accelerated charge transfer dynamics. This investigation provides novel insights into the strategic engineering of high-performance SAC-based electrochemical sensors by precisely controlling the atomic-scale structure of active sites.}, archive = {J_ANGEW}, author = {Bowen Jiang and Heng Zhang and Rui Pan and Min Ji and Lin Zhu and Guoju Zhang and Jing Liu and Huihui Shi and Huang Huang and Shu Wan and Kuibo Yin and Litao Sun}, doi = {10.1002/anie.202500474}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500474}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three-electron uric acid oxidation via interdistance-dependent switching pathways in correlated single-atom catalysts for boosting sensing signals}, volume = {64}, year = {2025}, }
• (2025). Aqueous zinc-ion batteries with boosted stability and kinetics under a wide temperature range. ANGEW, 64(20), e202500434. (www)

  @article{ , abstract = {Sustainable aqueous zinc ion batteries (AZIBs) necessitate a wide operational temperature range to ensure practicability, yet achieving this often compromises either reaction kinetics at low temperatures or cycling stability at high temperatures. Here we present an electrolyte design that balances this trade-off, enhancing the stability and kinetics of AZIBs across −60 to 60 °C. Our approach incorporates silk fibroin as a multifunctional additive into ZnCl 2 -based “water-in-salt” electrolyte, which modifies both electrolyte structure and electrode interphase. Specifically, Zn||Zn half-cells with this electrolyte realize low hysteresis (180 mV at 1 mA cm −2 ) at −60 °C, and stable operation (200 hours at 2 mA cm −2 ) at 60 °C. This electrolyte is compatible with both inorganic and organic cathode materials. Remarkably, an ampere-hour-level Zn||V 2 O 5 ⋅ n H 2 O pouch cell with this electrolyte achieves an energy density of ∼72 W h L −1 with minimal capacity decay after 50 cycles at 0.5 A g −1 . Furthermore, the pouch cell stably cycles across −60 to 60 °C. This strategy provides a powerful solution to the challenges of aqueous metal-ion batteries at extreme temperatures.}, archive = {J_ANGEW}, author = {Lei Zhang and Yu Han and Yaheng Geng and Hui Zhang and Hongguang Liu and Yan He and Zichao Yan and Zhiqiang Zhu}, doi = {10.1002/anie.202500434}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500434}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aqueous zinc-ion batteries with boosted stability and kinetics under a wide temperature range}, volume = {64}, year = {2025}, }
• (2025). Twist and shine: Ultra-narrow red emission from nitrogen and oxygen co-doped hetero-nanographenes. ANGEW, 64(20), e202500391. (www)

  @article{ , abstract = {Nanographenes, known for their exceptional optoelectronic properties, have garnered significant interest for their tunable electronic structures, particularly through heteroatom doping. Herein, we report the synthesis of two twisted hetero-nanographenes (h-NGs) co-doped with nitrogen and oxygen via a three-step strategy, where the tandem Pictet-Spengler cyclization and ipso -aromatic substitution serve as a key step. Both h-NGs incorporate a unique bis-fused diazacoronene (BFDAC) core, with one further extending the π-system via peri-fusion of four benzopyran units. Single-crystal analyses reveal that BFDAC core of both h-NGs adopts a highly twisted geometry, whereas the benzopyran-fused one has enhanced rigidity. Theoretical studies confirm a global aromaticity with 30 π-electrons delocalized along BFDAC periphery. Notably, co-doping enables precise electronic tuning, with pyridinic nitrogen lowering the LUMO level and benzopyran oxygen raising the HOMO level. Both h-NGs display the red photoluminescence (PL), and the benzopyran-fused derivative exhibits an ultra-narrow emission with a full-width at half-maximum of 19 nm, among the narrowest reported for organic red-emitting materials. Both h-NGs exhibit acid-responsive optical behavior including near-infrared absorption shift and PL quenching, providing additional functional versatility.}, archive = {J_ANGEW}, author = {Wei Jiang and Hongxiang Zhang and Xinqiang Hua and Yao Ma and Yawei Feng and Chengshan Yuan and Zitong Liu and Hao-Li Zhang and Xiangfeng Shao}, doi = {10.1002/anie.202500391}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Twist and shine: Ultra-narrow red emission from nitrogen and oxygen co-doped hetero-nanographenes}, volume = {64}, year = {2025}, }
• (2025). Efficient electrocatalytic semi-hydrogenation of alkynes by interfacial engineering of atomically precise silver nanoclusters. ANGEW, 64(20), e202500389. (www)

  @article{ , abstract = {Owing to its green energy and hydrogen sources, electrocatalytic semi-hydrogenation of alkynes is an attractive alternative for industrial alkene production. However, its broad application is hindered by low selectivity and low Faradaic efficiency (FE) due to side reactions like over-hydrogenation to alkanes. Here, we demonstrate that atomically precise Ag 25 (MHA) 18 nanoclusters (NCs) can electrocatalyze alkyne semi-hydrogenation with 98 % conversion, 99 % selectivity, and 85 % FE, in a broad substrate pool. This is achieved by engineering the local environment at the catalytically active sites. We leverage amphiphilic MHA (6-mercaptohexanoic acid) ligands to pre-concentrate water molecules and alkynes near the ligand-layer/Ag 25 interface. Long-chain ligands can disrupt the hydrogen-bond network at the interface, the high negative charge of Ag 25 can attract weakly hydrogen-bonded water through counterions and promote the generation of active hydrogen (H*), while the enzyme-like catalytic pockets on the surface of Ag 25 NCs facilitate adsorption of terminal alkynes via σ-bonding to the surface Ag atoms. Density functional theory calculations confirmed the preference of the σ-bonding model of alkyne and further revealed the facile release of product alkene. This work not only exemplifies an atomically precise interface engineering strategy to control the local environment of active sites for optimized activity and selectivity.}, archive = {J_ANGEW}, author = {Zhipu Zhang and Rongrong Yin and Ziyang Song and Manxi Zhang and Bihan Zhang and Shanshan Lu and Qiaofeng Yao and De-en Jiang and Jianping Xie and Wenping Hu}, doi = {10.1002/anie.202500389}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500389}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient electrocatalytic semi-hydrogenation of alkynes by interfacial engineering of atomically precise silver nanoclusters}, volume = {64}, year = {2025}, }
• (2025). Planar tetracoordinate oxygen atoms. ANGEW, 64(20), e202500292. (www)

  @article{ , abstract = {Planar tetracoordinate oxygen (ptO) atoms are rare, with only a few examples confirmed to date. This study systematically investigates 515 potential structures, formulated as OX n Y m q , where n + m =4, q ranging from +2 to −2, and following the 18-valence electron rule. High-level ab initio calculations identified 35 global minima containing a ptO atom, predominantly stabilized by Group 13 elements. Bonding analysis reveals a spectrum of interactions, from covalent to polar ionic, and confirms high electron delocalization. The findings challenge traditional bonding paradigms, improve the understanding of ptO-containing clusters, and propose viable ptO clusters for gas-phase detection, advancing the study of unconventional oxygen bonding.}, archive = {J_ANGEW}, author = {Gabriela Castillo-Toraya and Filiberto Ortíz-Chi and Jorge Barroso and Mesías Orozco-Ic and Luis Leyva-Parra and Gabriel Merino}, doi = {10.1002/anie.202500292}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500292}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Planar tetracoordinate oxygen atoms}, volume = {64}, year = {2025}, }
• (2025). Super-assembled lamellar conductive heterochannels with optical-electrical coupling sensitivity for smart ion transport. ANGEW, 64(20), e202500116. (www)

  @article{ , abstract = {Artificial nanofluidic devices inspired bylight-driven ion transport in biological systems, leveraging the photoelectric effect, have attracted extensive attention for their potential in signal transduction and smart ion transport applications. However, effective separation of photogenerated carriers in traditional p-n junction interface can be hindered by energy band structure of different semiconductor materials. Here, we present a novel approach using conductive polypyrrole (PPy) to modify graphene oxide (GO), creating polypyrrole-graphene oxide (PyGO) functional lamellar conductive nanochannels with tailored channel-sized gradients and inherent optical-electrical coupling sensitivity via a facile super-assembly strategy. This design facilitates the PyGO own conductive lamellar channels and efficient separation of photogenerated carriers, resulting in significantly enhanced selective ion transport behavior. Coupling the conductivity and photosensitivity of PPy contributes to a peak power density of 14.1 W m −2 under a salinity differential of 0.5/0.01 M NaCl, which is 35.6 % higher than that under dark conditions. Additionally, combing the salinity gradients with optical-electrical coupling sensitivity of the nanofludic devices, we demonstrate the application of PyGO in a real-time detection device for monitoring ion concentrations in nutrient solutions, paving the way for smart irrigation systems in agriculture. This work presents a novel and effective strategy for light-driven ion transport with potential applications in energy conversion and beyond.}, archive = {J_ANGEW}, author = {Yaxin Guo and Xin Zhang and Shan Zhou and Qirui Liang and Hui Zeng and Yeqing Xu and Abuduheiremu Awati and Kang Liang and Dazhang Zhu and Mingxian Liu and Lei Jiang and Biao Kong}, doi = {10.1002/anie.202500116}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500116}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Super-assembled lamellar conductive heterochannels with optical-electrical coupling sensitivity for smart ion transport}, volume = {64}, year = {2025}, }
• (2025). Exploiting bis-sulfonimide featuring multiple d–pπ bonds to construct interlayers for organic solar cells. ANGEW, 64(20), e202500096. (www)

  @article{ , abstract = {Herein, bis-sulfonimide (BSI), characterized by multiple d - p π bonds rather than typical p - p π bonds, is unprecedently utilized as a general and extendable building block to develop a series of multifunctional cathode interlayer materials (CIMs) for organic solar cells (OSCs). An illustrative CIM, BSIz-TT-PDI, demonstrates favorable alcohol processability, superior work function tunability, appropriate energy levels, strong self-doping effect, and decent crystallinity. These attributes contribute to its high conductivity exceeding 5×10 −3 S/cm, as well as precise optimization of the interfacial connection between the active layer and metal cathode. Therefore, BSIz-TT-PDI-based OSCs delivers an outstanding efficiency of 18.08 % using PM6:Y6 active layer while retaining 84 % of its initial performance after tracking at the maximum power point under continuous illumination for 1100 hours. Additionally, the devices maintain over 94 % of the optimal performance across a film thickness range of BSIz-TT-PDI from 5 to 90 nm. Moreover, BSIz-TT-PDI exhibits high compatibility with various active layers, enabling a record efficiency of 19.80 % with the PM6:BTP-eC9:L8-BO active layer. This work not only introduces a new library of water/alcohol-soluble n-type semiconductors containing BSI, while also pioneers the creation of thickness-insensitive CIMs for stable and efficient OSCs by integrating electron-withdrawing components with d - p π bonds.}, archive = {J_ANGEW}, author = {Yanhui Fan and Junjie Wen and Huanhuan Yang and Huixiang Zhang and Wentian Han and Zuhao You and Yuxing Wang and Wenxu Liu and Yao Liu}, doi = {10.1002/anie.202500096}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202500096}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploiting bis-sulfonimide featuring multiple d–pπ bonds to construct interlayers for organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Crystallization modulation and comprehensive defect passivation by carbonyl functionalized spacer cation towards high-performance inverted perovskite solar cells. ANGEW, 64(20), e202425605. (www)

  @article{ , abstract = {The inverted cesium/formamidinium (CsFA)-based methylammonium-free perovskite solar cells possess great potential in simultaneously realizing high power conversion efficiency (PCE) and excellent stability. However, the uncontrollable crystallization process and poor film quality hinder further enhancement of photovoltaic performance and operational stability. Herein, we propose a synergistic modulation strategy of perovskite crystallization and the defects at grain boundaries (GBs) and interface by using a novel carbonyl functionalized spacer cation. L-Alanine benzyl ester hydrochloride (L-ABEHCl) containing carbonyl functionalized ammonium cation is incorporated into perovskite precursor solution, increasing the nucleation rate and reducing the crystal growth rate because of its strong interaction with precursor components, leading to increased grain size and crystallinity. No 2D perovskite is formed for L-ABEHCl as additive whereas 2D perovskite is formed upon L-ABEHCl post-treatment. It is revealed that FA + and Cs + in precursor solution suppress the formation of 2D perovskite. As a result, the L-ABEHCl passivates the defects at GBs in the form of organic salts and passivates interface defects in the form of 2D perovskite. Due to minimized carrier nonradiative recombination losses, the inverted devices using synergistic modulation strategy achieve a maximum PCE of 25.77 % (certified stabilized PCE of 25.59 %), which is one of the highest PCEs ever reported for the devices based on vacuum flash evaporation method. The unencapsulated target device maintains 90.85 % of its initial PCE after 2300 h of continuous maximum power point tracking, among the most excellent stabilities accomplished by inverted devices.}, archive = {J_ANGEW}, author = {Shiying Tang and Zuolin Zhang and Yue Yu and Xinxing Liu and Dongmei He and Xuxia Shai and Jiajia Zhang and Jing Feng and Jianhong Yi and Cong Chen and Hua Yu and Jiangzhao Chen}, doi = {10.1002/anie.202425605}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425605}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystallization modulation and comprehensive defect passivation by carbonyl functionalized spacer cation towards high-performance inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Nanofabrication via SEM electron-beam stimulated Suzuki–Miyura type reaction: Fingerprints of carbazole derivative revealed by synchrotron-IR nanospectroscopy and mass spectrometry. ANGEW, 64(20), e202425591. (www)

  @article{ , abstract = {Carbazole-based compounds have demonstrated interesting physical and chemical properties for OLED devices. 3,6-diphenylcarbazole has a direct application in the composition of structures with potential to suppress the loss of efficiency under high luminance conditions along with its use in the emitting layer. In this study, we reveal and explore the conditions in which a triggered electron beams (e-beams) solid state Suzuki–Miyaura type reaction between 3,6-diiodocarbazole and phenylboronic acid could be carried out. Applying typical SEM acceleration voltage (30 keV), sufficient energy transfer enabled the activation of the reaction. Synchrotron Infrared Nano Spectroscopy (SINS) was used to acquire nanoscale molecular vibrational spectra and compare with conventional FTIR absorption spectra for chemical characterization. Evidences obtained by mass spectrometry confirmed the formation of the 3,6-diphenyl-9H-carbazole under higher e-beam dose (30 keV, 10 minutes), when compared to 5 and 10 keV. In addition, the phenylboronic acid seems to have a role in the reaction outcome. Both samples irradiated in the presence and in the absence of palladium exhibited the fingerprints of the expected product 3,6-diphenylcarbazole shedding light on possible alternative mechanisms and the straightforward construction of nanodevices.}, archive = {J_ANGEW}, author = {Matheus Costa Ximenes and Luiz Phelipe de Souza Tomaso and Igor Zanetti and Amanda Beatriz Silva Quirgo dos Reis and Eustáquio de Souza Baêta Júnior and Leticia dos Santos Aguilera and Suzana Bottega Peripolli and Lucyano Jefferson Alves Macedo and Raul de Oliveira Freitas and Luiz Fernando Brum Malta and José Brant de Campos and Jaqueline Dias Senra}, doi = {10.1002/anie.202425591}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425591}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanofabrication via SEM electron-beam stimulated Suzuki–Miyura type reaction: Fingerprints of carbazole derivative revealed by synchrotron-IR nanospectroscopy and mass spectrometry}, volume = {64}, year = {2025}, }
• (2025). Nanourchin-like uricase-Poly(L-proline) conjugate with retained enzymatic activity, mitigated immunogenicity, and sustained efficacy upon repeated administrations. ANGEW, 64(20), e202425559. (www)

  @article{ , abstract = {The poor half-life and strong immunogenicity of proteins such as uricase (UOx), a therapeutic enzyme for chronic refractory gout and hyperuricemia, are pressing clinical challenges. Although conjugation of poly(ethylene glycol) (PEGylation) of UOx can improve the pharmacokinetics, preexisting or induced anti-PEG antibodies, which lead to accelerate blood clearance (ABC) and reduced response rate, have been a major clinical hurdle. Herein, we report the facile “grafting-from” preparation of a nanourchin-like uricase-poly( L -proline) conjugate, namely UOx-PLP, with high grafting-density, enhanced thermal, lyophilization, freeze-thaw, and proteolytic stability. Through a transient preblocking strategy in the synthesis, the UOx-PLP overcomes activity loss and retains ~82 % enzyme activity. In Sprague-Dawley rats, UOx-PLP stimulates minimum complement activation and anti-UOx antibodies. Unlike PEG-UOx gave a significantly reduced half-life after repetitive administrations, UOx-PLP shows no sign of ABC effect. Moreover, the half-life of UOx-PLP remain almost unchanged when cross-administrated to rats previously received PEG-UOx and with high titers of anti-UOx antibodies. Finally, UOx-PLP shows minimum loss of efficacy after five straight administrations in a UOx knock-out hyperuricemia mice model, whereas PEG-UOx experiences sharp loss of efficacy upon the same treatment. Overall, the simple preparation and outstanding nonclinical results highlight the enormous potential of UOx-PLP for future clinical translation.}, archive = {J_ANGEW}, author = {Ruichi Zhao and Yangming Zhang and Banlai Ruan and Hairuo Zhang and Niannian Lv and Jiayi Li and Yuhe R. Yang and Xiaozhou Luo and Hua Lu}, doi = {10.1002/anie.202425559}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425559}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanourchin-like uricase-Poly(L-proline) conjugate with retained enzymatic activity, mitigated immunogenicity, and sustained efficacy upon repeated administrations}, volume = {64}, year = {2025}, }
• (2025). Anion adsorption at the inner-helmholtz plane directs cathode electrolyte interphase formation. ANGEW, 64(20), e202425535. (www)

  @article{ , abstract = {Constructing a stable cathode-electrolyte-interphase (CEI) on cathode surface constitutes the foundation of realizing high-voltage Li-ion batteries, yet its formation, a highly heterogeneous process involving irreversible reactions between electrolyte components and cathode materials, remains poorly understood. Herein, combining multiple in situ / operando interfacial characterization techniques, we establish the correlation between interfacial structure and interphasial chemistry, and reveal the key role played by adsorptive behavior of various electrolyte components in the inner-Helmholtz plane during CEI formation. Quartz crystal microbalance equipped with dissipation modification detects that difluorooxalatoborate (DFOB − ) anion preferentially adsorbed on LiCoO 2 tends to expel carbonate solvents from the adsorption layer, thus suppressing their electrochemical decomposition at high voltages and leading to a more compact CEI derived from anions with limited contribution from organic ingredients. Consequently, the CoO 2 lattice structure protected by the dense CEI remains intact despite near-complete delithiation, thereby ensuring excellent cycling stability for 4.7 V operation of LiCoO 2 cathode. The atomistic-level insight into the key factors that govern CEI formation provides directive knowledge that accelerates electrolyte design for high-voltage batteries.}, archive = {J_ANGEW}, author = {Yuchen Ji and Yuxiang Huang and Zihang Dong and Jianjun Fang and Peng Liu and Shiqi Liu and Aimin Cao and Haoyu Xue and Shiming Chen and Jimin Qiu and Peng-Hu Du and Kunchen Xie and Shida Xue and Tao Shen and Guorui Zheng and Xiyao Zhao and Zu-Wei Yin and Kai Yang and Hai Lin and Kang Xu and Feng Pan and Luyi Yang}, doi = {10.1002/anie.202425535}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425535}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion adsorption at the inner-helmholtz plane directs cathode electrolyte interphase formation}, volume = {64}, year = {2025}, }
• (2025). Palladium-catalyzed enantioselective C–H arylations and alkenylations of 2-aminobiaryls with atmospheric air as the sole oxidant. ANGEW, 64(20), e202425512. (www)

  @article{ , abstract = {Optically active 2-aminobiaryls are valuable chiral frameworks with broad applications in catalysis, synthetic chemistry, and materials science. Here, we present a simple and practical methodology for their asymmetric synthesis via enantioselective palladium catalyzed C−H arylations or alkenylations of racemic precursors. The methodology utilizes a kinetic resolution strategy, producing two highly valuable enantioenriched axially chiral molecules: the C−C coupling product and the unreacted starting material. Notably, we have established reaction conditions that enable the in situ regeneration of the active Pd(II) catalyst using atmospheric air as the sole oxidant. Finally, we showcase the synthetic utility of this approach by preparing several derivatives relevant to the field of asymmetric catalysis.}, archive = {J_ANGEW}, author = {Laura Goicoechea and Pablo Losada and José Luis Mascareñas and Moisés Gulías}, doi = {10.1002/anie.202425512}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425512}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Palladium-catalyzed enantioselective C–H arylations and alkenylations of 2-aminobiaryls with atmospheric air as the sole oxidant}, volume = {64}, year = {2025}, }
• (2025). Asymmetric triple-atom sites combined with oxygen vacancy for selective photocatalytic conversion of CO2 to propionic acid. ANGEW, 64(20), e202425446. (www)

  @article{ , abstract = {Photocatalytic CO 2 reduction to multicarbon products is an emerging approach for achieving carbon neutrality; however, the design of active sites that effectively promote multistep C−C coupling remains a challenge. Here, we propose a straightforward defect engineering approach to construct asymmetric triple-atom sites (Cu-Cu δ+ -W δ+ ) on CuWO 4 with oxygen vacancies (OVs) (named CWO-OVs). The optimized CWO-OVs achieve a photochemical synthesis rate of propionic acid (C 3 H 6 O 2 , PA) of 86.46±2.92 μmol g −1 h −1 , with an electron-based selectivity of 89.27 %, which exhibits a remarkable advantage in the field of photocatalytic CO 2 reduction to C 2+ products. Experimental results and density functional theory calculations corroborate the prominent role of OVs in inducing the triple-atom sites: (1) the asymmetric Cu-Cu δ+ triggers the first step of C 1 -C 1 coupling to form *CH 2 CH 3 ; (2) Cu δ+ -W δ+ facilitates subsequent C 2 -C 1 bonding, ultimately leading to PA production. This charge-asymmetric cascade reaction system offers new insights into the design of efficient photocatalysts for the synthesis of multi-carbon products.}, archive = {J_ANGEW}, author = {Haiwei Su and Haibo Yin and William Orbell and Yuqing Li and Guoliang Wang and Yunlong Wang and Kohsuke Mori and Zhen Chen and Hexing Li and Hiromi Yamashita and Junhua Li}, doi = {10.1002/anie.202425446}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425446}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric triple-atom sites combined with oxygen vacancy for selective photocatalytic conversion of CO2 to propionic acid}, volume = {64}, year = {2025}, }
• (2025). Constructing dense morphology of sn with high reversibility under high areal-capacity for anode-free tin batteries. ANGEW, 64(20), e202425419. (www)

  @article{ , abstract = {Sn electrode possesses high reversibility, redox kinetics and corrosion resistance, as well as non-toxic and environmental compatibility, which is competitive candidate for aqueous batteries. However, due to huge size of deposition particles and “dead Sn”, it is a great challenge to obtain high areal-capacity (>5 mAh cm −2 ) and high coulombic efficiency (>99 %) simultaneously. Here, we demonstrate a highly reversible Sn redox electrochemistry with high areal-capacity enabled by thiourea additive. Systematical investigations reveal the participation of thiourea molecules in the electrical double layer, reducing exchange current density and suppressing rampant two-dimensional diffusion. As a result, flat and dense scale-like deposition Sn morphology is obtained, which enables high cycle stability with high areal-capacity of 10 mAh cm −2 for symmetrical cell with lean electrolyte (25 μL cm −2 ), and delivering a high average coulombic efficiency of 99.85 % with practical high 5 mAh cm −2 area-capacity for asymmetrical cell. More importantly, anode-free Organic||Sn battery is developed, and 62 % capacity retention can be obtained after 570 cycles.}, archive = {J_ANGEW}, author = {Fengyi Zhang and Xi Zhang and Yu Shu and Hongjie Xiao and Qiong Wang and Qiang Guo and Yonggang Wang and Jianhang Huang and Yongyao Xia}, doi = {10.1002/anie.202425419}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425419}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing dense morphology of sn with high reversibility under high areal-capacity for anode-free tin batteries}, volume = {64}, year = {2025}, }
• (2025). Reinforced nonlinear optical performances induced by P-P homoatomic bond in phosphide SrIn3Si4P11. ANGEW, 64(20), e202425384. (www)

  @article{ , abstract = {Phosphides exhibit great promise as a nonlinear optical (NLO) material system; however, the challenge of simultaneously achieving robust second-harmonic generation (SHG) response, wide band gap, and large birefringence within a single structure remains daunting. Herein, by leveraging the design concept of “multi-asymmetric-module integration”, we have successfully harvested a brand-new non-centrosymmetric phosphide SrIn 3 Si 4 P 11 , which showcases the characteristics of a three-dimensional framework constructed by diverse [Si 3 P 10 ] and [In 3 P 10 ] trimers, as well as P−P homoatomic bonds. The introduction of P−P bond distinguishes SrIn 3 Si 4 P 11 from the kindred SrIn 3 Si 4 P 9 , ultimately resulting in “killing three birds with one stone”, including a remarkable 30-fold enhancement in SHG intensity, a 2.5-fold increase in birefringence, as well as a 0.50 eV broadening in band gap compared to SrIn 3 Si 4 P 9 . Theoretically calculated analysis reveals that the π interactions and the significant polarization anisotropy of the P−P bond are critical factors contributing to the enhancement of NLO performances. The present study uncovers the pivotal significance of P−P bond in structural design and NLO properties optimization, and delineates a clear research direction for the extensive advancement of phosphides NLO materials.}, archive = {J_ANGEW}, author = {Shao-Min Pei and Ming-Shu Zhang and Xiao-Ming Jiang and Bin-Wen Liu and Guo-Cong Guo}, doi = {10.1002/anie.202425384}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425384}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reinforced nonlinear optical performances induced by P-P homoatomic bond in phosphide SrIn3Si4P11}, volume = {64}, year = {2025}, }
• (2025). Highly strained electron-rich molecular bowl and nanographene. ANGEW, 64(20), e202425355. (www)

  @article{ , abstract = {Introducing two pyrrole rings at the armchair edges of perylene creates the small, electron-rich molecular bowl 1 , which can be viewed as a nitrogen-doped end-cap of C 70 . Despite numerous attempts since 2008, its synthesis has been hindered by strain and synthetic challenges. In this study, we present the synthesis and property analysis of molecular bowl 1 and its dimer, the wavy-shaped nanographene 2 . Substituents on nitrogen atoms significantly affect the bowl depth, intermolecular interactions, and supramolecular behaviors. Consequently, the butyl-substituted molecular bowl 1 a forms unusual polar crystals with all bowls oriented similarly, suggesting potential pyroelectric or ferroelectric applications. Due to the electron-rich nature, compounds 1 exhibit significantly strong binding affinity towards fullerene, with 1 a forming a sandwich structure with C 70 . Furthermore, neutral bowls 1 display counter-rotating ring currents similar to corannulene, while their dications exhibit global anti-aromaticity. The wavy-structured nanographene 2 demonstrates two continuously reversible oxidation processes, and its dication 2 2+ shows remarkably high stability under ambient conditions. In summary, this work constructs a small, electron-rich molecular bowl and its nanographene dimer, highlighting their exceptional properties, promising applications, and potential as foundations for future advanced nanostructure fabrication.}, archive = {J_ANGEW}, author = {Wenhao Zhang and Yeda Ding and Shanzi Yu and Jiaqi Lyu and Jiaxuan Yu and Jiawen Li and Xin Zhao and Lina Feng and Jianguo Wang and Zheng Zhou and Qing Wang}, doi = {10.1002/anie.202425355}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425355}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly strained electron-rich molecular bowl and nanographene}, volume = {64}, year = {2025}, }
• (2025). Xenon trioxide coordination complexes of crown ethers: (CH2CH2O)4XeO3 and Xe(VI) hydrates, [(CH2CH2O)6(H2O)XeO3]⋅ H2O and [(CH2CH2O)6(H2O)XeO3]2 ⋅ 2H2O ⋅ HF. ANGEW, 64(20), e202425216. (www)

  @article{ , abstract = {Following on our report of the first coordination complex between a noble-gas compound and a crown ether, (CH 2 CH 2 O) 5 XeO 3 , the reactions and structures of XeO 3 complexes with 12-crown-4 and 18-crown-6 were investigated. The reactions of 12-crown-4 and 18-crown-6 with XeO 3 in dilute aqueous HF solutions yielded (CH 2 CH 2 O) 4 XeO 3 and [(CH 2 CH 2 O) 6 (H 2 O)XeO 3 ] 2 ⋅ 2H 2 O ⋅ HF, whereas reactions of 12-crown-4 and 18-crown-6 with moist solid XeO 3 in acetone solutions yielded (CH 2 CH 2 O) 4 XeO 3 and [(CH 2 CH 2 O) 6 (H 2 O)XeO 3 ] ⋅ H 2 O. The (CH 2 CH 2 O) 4 XeO 3 and [(CH 2 CH 2 O) 6 (H 2 O)XeO 3 ] ⋅ H 2 O complexes are air-stable and shock-insensitive, whereas [(CH 2 CH 2 O) 6 (H 2 O)XeO 3 ] 2 ⋅ 2H 2 O ⋅ HF is a treacherous, shock-sensitive detonator. Low-temperature X-ray crystal structures show that XeO 3 is coordinated to the crown ether and H 2 O through short Xe- - -O contacts. Mappings of the XeO 3 Hirshfeld surfaces onto 12-crown-4 and 18-crown-6 in (CH 2 CH 2 O) 4 XeO 3 and [(CH 2 CH 2 O) 6 (H 2 O)XeO 3 ] ⋅ H 2 O reveal regions of negative electrostatic potential (EP) on the oxygen atoms of the crown ethers and regions of high positive EP on the Xe(VI) atom of XeO 3 that are consistent with σ-hole bonds. The calculated gas-phase geometries, Wiberg bond valences and indices, and empirical bond valences corroborate the descriptions of the shortest Xe- - - contacts as σ-hole bonds. The 12-crown-4, 15-crown-5, and 18-crown-6 complexes of XeO 3 are also compared with the X-ray crystal structures and calculated gas-phase structures of their SbF 3 and SbCl 3 analogues.}, archive = {J_ANGEW}, author = {Katherine M. Marczenko and Hélène P. A. Mercier and James T. Goettel and Gary J. Schrobilgen}, doi = {10.1002/anie.202425216}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425216}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Xenon trioxide coordination complexes of crown ethers: (CH2CH2O)4XeO3 and Xe(VI) hydrates, [(CH2CH2O)6(H2O)XeO3]⋅ H2O and [(CH2CH2O)6(H2O)XeO3]2 ⋅ 2H2O ⋅ HF}, volume = {64}, year = {2025}, }
• (2025). Evolution-guided discovery of antimycobacterial triculamin-like lasso peptides. ANGEW, 64(20), e202425134. (www)

  @article{ , abstract = {Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene cluster (BGC). In this study, we elucidate the biosynthetic pathway of triculamin through heterologous expression and show that the biosynthesis proceeds in the presence of a precursor (triA), macrocyclase (triC), and N-acetyltransferase (triT). Through in vitro triT acetylation and bioactivity assays, we show that acetylation functions as a resistance mechanism. Genomic searches of triculamin BGC genes across bacteria show that triculamin is more widely distributed than previously anticipated, as triculamin-like core peptides are found in at least three phyla in contrast to previously described lasso peptides that are typically restricted to one phylum. Triculamin BGCs with both canonical and non-canonical RiPP biosynthetic genes were identified. Two strains containing canonical triculamin-like BGCs were chemically characterized and shown to produce the novel triculamin-like lasso peptides palmamin and gelatinamin, the latter of which appears to have an unprecedented additional ring formation. Detailed phylogenetic investigation of the macrocyclases from triculamin-like BGCs suggests that these molecules are products of convergent evolution. These findings broaden the evolutionary and functional landscape of lasso peptides, revealing their unexpected diversification and cross-phylum distribution.}, archive = {J_ANGEW}, author = {Aske Merrild and Tiziana Svenningsen and Marc G. Chevrette and Thomas Tørring}, doi = {10.1002/anie.202425134}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425134}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evolution-guided discovery of antimycobacterial triculamin-like lasso peptides}, volume = {64}, year = {2025}, }
• (2025). Achieving free-electron transfer reversal and dz2-orbital occupancy modulation on core-shell NiS@Au cocatalysts for highly selective H2O2 photosynthesis. ANGEW, 64(20), e202425038. (www)

  @article{ , abstract = {Spontaneous free-electron migration usually occurs on the interface between host photocatalysts and cocatalysts, but the influences of the charge transfer direction on the two-electron oxygen reduction reaction (2e − -ORR) of cocatalysts have not been taken seriously. Herein, an innovative electron-transfer reversal is proposed to direct the free-electron transfer in a way that enables highly selective 2e − -ORR on Au cocatalysts. To this end, metallic Au nanoparticles are originally loaded on NiS particles to fabricate novel core–shell NiS@Au cocatalysts on g-C 3 N 4 surface by a directional photodeposition procedure. XAS spectra and DFT calculations disclose that the intergrated NiS induces a reversed free-electron transfer from Au nanoparticles to NiS core, thus essentially modulating d z 2 -orbital occupancy of Au atoms to enhance O 2 adsorption and stabilize key *OOH intermediates, endowing core–shell NiS@Au cocatalysts with a highly selective 2e − -ORR process for efficient H 2 O 2 evolution. Consequently, the optimized g-C 3 N 4 /NiS@Au photocatalyst achieves a remarkably promoted H 2 O 2 -production rate of 264.82 μmol/h/50 mg in the air environment, possessing a high apparent quantum efficiency of 8.07 % under visible light. This work provides novel insights on purposefully steering free-electron transfer direction to engineer dz 2 -orbital occupancy, offering a feasible approach for designing highly active photocatalysts and beyond.}, archive = {J_ANGEW}, author = {Wei Zhong and Aiyun Meng and Yaorong Su and Huogen Yu and Peigang Han and Jiaguo Yu}, doi = {10.1002/anie.202425038}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425038}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving free-electron transfer reversal and dz2-orbital occupancy modulation on core-shell NiS@Au cocatalysts for highly selective H2O2 photosynthesis}, volume = {64}, year = {2025}, }
• (2025). Self-driven CuAAC reaction catalyzed by photosensitive biohybrids energized by lactate for boosting cancer immunotherapy. ANGEW, 64(20), e202425018. (www)

  @article{ , abstract = {As a typical bioorthogonal reaction, the copper (I) catalyzed azide-alkyne 1,3-cycloaddition (CuAAC) reaction strongly depends on the reducing agents and the rate of the CuAAC reaction is far from sufficient to produce drug agents under physiological conditions. It is necessary and highly demanding to develop an efficient CuAAC reaction without using chemical reducing agents. Herein, inspired by the extracellular electron transfer (EET) mechanisms of the electroactive bacteria within the realm of synthetic biology, a photo-assisted targeting electroactive bacteria equipped bioorthogonal catalyst system for boosting cancer immunotherapy is constructed. The bacteria specifically anaerobically catabolize lactate at the tumor site, accompanied by transferring electrons to the bioorthogonal catalyst, thereby triggering the CuAAC reaction to produce active drugs in situ. Strikingly, under illumination, the photoelectrons generated by attached AuNPs can be transported into bacterial cytoplasm to accelerate the CuAAC reaction by promoting cellular metabolism. The biohybrid enables synergistic immunogenic cell death (ICD), immune checkpoint blockade (ICB) immunotherapy and alleviation of immunosuppressive microenvironment. Ingeniously, ICD and lactate consumption both boost the efficacy of ICB immunotherapy. Overall, the system provides a bridge between the tumor metabolism and CuAAC reaction through bacterial respiration, offering fascinating opportunities for controlled synthesis of active molecules by bioorthogonal catalysis.}, archive = {J_ANGEW}, author = {Huisi Zhao and Yu Zhang and Yue Sun and Zitong Zhu and Jinsong Ren and Xiaogang Qu}, doi = {10.1002/anie.202425018}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202425018}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-driven CuAAC reaction catalyzed by photosensitive biohybrids energized by lactate for boosting cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Stefan-boltzmann water catalyzed propane dehydrogenation. ANGEW, 64(20), e202424800. (www)

  @article{ , abstract = {The traditional wisdom of utilizing water in practical olefin synthesis has been viewed as a means to reduce alkane partial pressure and assist in coke removal. However, under such harsh reaction conditions, the potential catalytic role of the water molecule remains unclear. This study explores the intriguing concept that the water molecule, through the selective excitation of molecular vibrations and collisions induced by thermal energy and thermal radiation, could act as a catalyst in homogeneous gaseous propane dehydrogenation. This occurs via the generation of the OH⋅ radicals, resulting in an olefin yield of 37.93 %, a single pass propane conversion of 51.14 %, and an excellent stability of more than 2000 hours.}, archive = {J_ANGEW}, author = {Xue Ding and Zichan Zheng and Chengyuan Liu and Junchuan Sun and Yongcai Zhang and Chen Huang and Wenguang Tu and Long Zhao and Zhixin Hu and Zhigang Zou and Lu Wang}, doi = {10.1002/anie.202424800}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424800}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stefan-boltzmann water catalyzed propane dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Heterogeneous fe-N-C cocatalyst for hydroquinone oxidation enables aerobic oxidation of primary alcohols to aldehydes. ANGEW, 64(20), e202424778. (www)

  @article{ , abstract = {Benzoquinone (BQ) is commonly used as a cocatalyst in multi-component catalyst systems for aerobic oxidation of organic molecules. Such methods often proceed by a redox cascade in which a secondary catalyst supports aerobic oxidation of hydroquinone (HQ) to BQ. The present study shows that a commercially available non-precious metal heterogeneous catalyst, PAJ-Fe-N-C, is much more efficient than established homogeneous catalysts for aerobic oxidation of HQ to BQ, and this improved reactivity is crucial to support aerobic oxidation of primary alcohols to aldehydes with the homogeneous iridium catalyst, [Ir(trop 2 DAD]OTf (trop 2 DAD= N , N -bis(5- H -dibenzo[ a , d ]cycloheptene-5-yl)-1,4-diazabuta-1,3-diene). The combination of this heterogeneous/homogeneous catalyst system operates with Ir catalyst loadings as low as 0.05 mol % and turnover frequencies ≥350 h −1 .}, archive = {J_ANGEW}, author = {Md Asmaul Hoque and Clara Schweinzer and Jesse J. Martinez and Friederike Tewes and Vittorio Sacchetti and Hansjörg Grützmacher and Shannon S Stahl}, doi = {10.1002/anie.202424778}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424778}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterogeneous fe-N-C cocatalyst for hydroquinone oxidation enables aerobic oxidation of primary alcohols to aldehydes}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic radical bis(trifluoromethyl)carbinolation of alkenes and heteroarenes. ANGEW, 64(20), e202424757. (www)

  @article{ , abstract = {Structural modification of drug candidates with fluorine atoms has revolutionized drug discovery, frequently enhancing pharmacological properties. However, the strategic integration of privileged bis(trifluoromethyl)carbinol moiety remains challenging, primarily due to the overreliance on closed-shell strategies typically involving toxic gaseous hexafluoroacetone. Alternative radical-based strategies exist but are constrained by the inherently weak electrophilicity of the key bis(trifluoromethyl)carbinol radical intermediate, significantly limiting the scope of accessible transformations. Here we report the development of a novel masked bis(trifluoromethyl)carbinolation reagent, enabling the efficient generation of bis(trifluoromethyl)carbinol radical species with significantly enhanced electrophilicity under mild photocatalytic conditions. This approach facilitates chloro- and oxy-bis(trifluoromethyl)carbinolation of versatile alkenes, alongside highly selective C2−H bis(trifluoromethyl)carbinolation of diverse heteroarenes, providing streamlined access to a structurally diverse array of alkyl and aryl bis(trifluoromethyl)carbinols previously considered synthetically challenging.}, archive = {J_ANGEW}, author = {Shiqin Qiu and Xiaoye Yu and Huaixuan Guo and Jian Li and Xinyao Li and Peng Xu}, doi = {10.1002/anie.202424757}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424757}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic radical bis(trifluoromethyl)carbinolation of alkenes and heteroarenes}, volume = {64}, year = {2025}, }
• (2025). Chemocatalytic cell tagging platform for recording cell-cell interactions via engineered palladium-based artificial metalloenzymes. ANGEW, 64(20), e202424738. (www)

  @article{ , abstract = {Proximity labeling platforms (PLPs) have become a powerful tool for studying spatial cell-cell interactions (CCIs) in living organisms. However, their effectiveness often relies on membranal catalytic modules of bait cells, such as natural enzymes or small-molecule photocatalysts, which are typically constrained by complex genetic modifications or the limited applicability of visible light. Here, we present a novel chemocatalytic approach, ArM-Tag, which utilizes an engineered artificial metalloenzyme (ArM) for cell surface-localized tagging. The ArM-Tag system combines a palladium (Pd) cofactor, a lipid anchor, and a streptavidin (SAV) scaffold to catalyze the O -deallylation reaction on the surface of target cells, generating short-lived electrophilic intermediates that label neighboring cells within a micrometer-scale range. By integrating Biotin-SAV technology with directed evolution, we engineered a series of biotinylated Pd complexes and optimized the ArM for efficient catalysis. We demonstrate the power of this approach by applying the ArM-Tag system to selectively record antigen-specific CCIs, specifically showing how CAR−T cells interact with tumor cells through the mesothelin/anti-mesothelin axis. This versatile, non-genetic system provides a powerful tool for probing CCIs and offers exciting prospects for advancing immunotherapy, particularly in targeted cancer treatments and immune cell-based therapies.}, archive = {J_ANGEW}, author = {Zhiguo Gao and Ke Qin and Wei He and Yi Liang and Jiaying Yu and Zhimei Wang and Xuejing Li and Jian Chen and Zhuoer Cai and Jinzhong Hu and Huayu Liu and Dandan Wang and Yaojia Li and Baiwang Sun}, doi = {10.1002/anie.202424738}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424738}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemocatalytic cell tagging platform for recording cell-cell interactions via engineered palladium-based artificial metalloenzymes}, volume = {64}, year = {2025}, }
• (2025). Roadmap to catalytic abatement of gas phase per- and polyfluoroalkyl substances (PFAS). ANGEW, 64(20), e202424718. (www)

  @article{ , abstract = {While the outstanding stability of per- and polyfluoroalkyl substances (PFAS) paved the way for their widespread application in a huge variety of applications, it also resulted in their nickname “forever chemicals”. The rising awareness for PFAS-related environmental and health concerns drives a discussion on the most effective ways to abate PFAS emissions into the environment, i.e. water, soil, and air, and remediation of contaminated matter. In order to address the knowledge gap regarding air pollution by PFAS, this minireview summarizes the current corpus of work in the field and outlines how catalysis can contribute to PFAS abatement in the gas phase. Beyond a mere collection of state-of-the-art knowledge, overarching challenges in catalytic PFAS removal are identified, spanning from fundamental organic and inorganic chemistry, i.e. C−F-bond activation, to heterogeneous catalysis, i.e. surface reactions at the gas-solid interface, to reaction engineering, i.e. scaling relations and technical hurdles. In addition, the article introduces concepts and workflows that aim at providing guidance during the design of technological solutions for the efficient control of gaseous PFAS emissions.}, archive = {J_ANGEW}, author = {Patrick Lott and Florian Maurer and Arik Beck}, doi = {10.1002/anie.202424718}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424718}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Roadmap to catalytic abatement of gas phase per- and polyfluoroalkyl substances (PFAS)}, volume = {64}, year = {2025}, }
• (2025). Preparation of peapod-like nano-copolymers with periodic sequence via polymerization-induced morphology differentiation and fusion. ANGEW, 64(20), e202424666. (www)

  @article{ , abstract = {Inorganic nanoparticles have so far dominated the field of nanoparticle assembly, and assembly of pure organic nanoparticles (such as block copolymer nanoparticles) has rarely been examined in colloidal systems. Expanding the scope of nanoparticles is of great significance for the study of nanoparticle assembly. Herein, a paradigm for the copolymerization of organic nanoparticles into peapod-like linear nanostructures with periodic sequence is introduced. Vesicles and porous spheres are generated in situ during polymerization-induced self-assembly (PISA) and can be viewed as nanoscale monomers (“nanomers”). The subsequent copolymerization of these nanomers is completed in one-pot, which greatly simplifies the preparation of nanomers and peapod-like nano-copolymers. It is demonstrated that appropriate π–π stacking interactions are crucial to the formation of nanomers and their copolymerization progress. Notably, the research subjects in nano-copolymers with periodic sequence have expanded to organic nanoparticles, which is beneficial to further expand the horizons of nanoparticle assembly. Moreover, the multiple separated compartments in the peapod-like nano-copolymers will open new directions toward development of artificial organelle and on-demand catalysis in different compartments within the same nano-object.}, archive = {J_ANGEW}, author = {De-Peng Yin and Xin-Yue Zhao and Jia-Min Cheng and Ren-Man Zhu and Chao Liu and Chun-Yan Hong}, doi = {10.1002/anie.202424666}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424666}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Preparation of peapod-like nano-copolymers with periodic sequence via polymerization-induced morphology differentiation and fusion}, volume = {64}, year = {2025}, }
• (2025). Enabling solid-electrolyte interphase formation prior to water reduction in aqueous zinc batteries by mild protic chemistry. ANGEW, 64(20), e202424642. (www)

  @article{ , abstract = {Challenges like hydrogen evolution reaction (HER) and dendrite formation on zinc anodes hinder the practical application of aqueous zinc batteries (AZBs), primarily due to the lack of an exceptional passivating solid-electrolyte interphase (SEI). To effectively prevent water decomposition, it is essential to in situ construct SEI prior to water reduction. This study shifts the focus from aprotic to protic SEI chemistry and predicts reduction potentials of mild protic compounds using thermodynamics. Based on this insight, mild protic 2-mercapto-1-methylimidazole (MMI) is introduced and found to be reduced prior to water at higher electrode potentials, as MMI exhibits slightly higher proton activity than water due to its thiol group. The reduction of MMI produces isothiocyanate species via a proposed electrocatalytic ring cleavage mechanism, which deposit on zinc anodes to form an SEI predominantly composed of organic compounds supplemented with Zn(OH) 2 . Benefiting from the unique advantage of preferential reduction before water, the MMI-derived SEI exhibits a superior passivating effect, as evidenced by a two-order-of-magnitude reduction in corrosion current of zinc anodes from 1170 μA cm −2 to 13.6 μA cm −2 . The SEI effectively suppresses HER, and ensures dendrite-free zinc deposition, leading to high reversible zinc anodes with exceptional electrochemical performances.}, archive = {J_ANGEW}, author = {Taiqiang Chen and Yunfei Wang and Xin Li and Tao Yuan and Yuepeng Pang and Shiyou Zheng}, doi = {10.1002/anie.202424642}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424642}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enabling solid-electrolyte interphase formation prior to water reduction in aqueous zinc batteries by mild protic chemistry}, volume = {64}, year = {2025}, }
• (2025). Chemoenzymatic synthesis of highly O-glycosylated MUC7 glycopeptides for probing inhibitory activity against pseudomonas aeruginosa biofilm formation. ANGEW, 64(20), e202424312. (www)

  @article{ , abstract = {MUC7, a highly glycosylated protein in saliva and respiratory tract, plays potential roles in facilitating bacterial clearance and preventing microbial invasion. The complexity of glycan structures and multiplicity of glycosylation sites of MUC7 make it very difficult to explore accurate biofunctions against pathogens. Here, we report an efficiently convergent chemoenzymatic approach to firstly synthesize highly O -glycosylated MUC7 glycopeptides with nine glycosylation sites bearing various glycoforms via the combined use of hydrophobic tag-assisted liquid-phase peptide synthesis and enzymatic-catalyzed glycan elongation. Biological evaluations reveal that different glycoforms of synthetic MUC7 glycopeptides mediate unique activities against biofilm formation of Pseudomonas aeruginosa , among which sialylated MUC7 glycopeptide exhibits better inhibitory activity and has the potential to develop antibacterial drugs.}, archive = {J_ANGEW}, author = {Wenjing Ma and Junyuan Luo and Huan Liu and Qi Du and Tianhui Hao and Yinyu Jiang and Zhengwei Huang and Lefu Lan and Zhonghua Li and Tiehai Li}, doi = {10.1002/anie.202424312}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemoenzymatic synthesis of highly O-glycosylated MUC7 glycopeptides for probing inhibitory activity against pseudomonas aeruginosa biofilm formation}, volume = {64}, year = {2025}, }
• (2025). An adhesive adaptation layer mitigates the interfacial instabilities of rigid polymer electrolyte. ANGEW, 64(20), e202424304. (www)

  @article{ , abstract = {Solid polymer electrolytes (SPEs) are widely recognized as promising candidates for enabling solid-state lithium metal batteries (SSLMBs) with improved safety, high energy density, and extended cycling life. The traditional perspective posits that increasing the mechanical modulus of SPEs enhances their capacity to regulate Li 0 deposition and suppress dendrite penetration. However, this study reveals a distinct failure mechanism: a rigid SPE with a high storage modulus suffers from delamination-induced cell failure due to its inability to accommodate the volumetric changes of the Li 0 anode. To address these limitations, we developed a hierarchical SPE incorporating an adhesive adaptation layer (AAL) positioned between the Li 0 anode and the rigid SPE. The AAL combines strong adhesive strength, effectively mitigating delamination, with flowability, allowing it to eliminate interfacial voids and defects. Structural characterization via Cryo-TEM and SEM demonstrates that this hierarchical design facilitates uniform, dense, and whisker-free Li 0 deposition, in sharp contrast to the uneven and porous morphology observed with the rigid SPE alone. Furthermore, the enhanced interfacial stability promotes the formation of an inorganic-enriched SEI layer, contributing to long-term cycling stability. As a result, the H-SPE exhibits superior electrochemical performance, achieving 87 % capacity over 960 cycles when paired with high-loading (1.6 mAh/cm 2 ) NMC622 cathode.}, archive = {J_ANGEW}, author = {Yubin He and Peng Zhao and Lei Wang and Yaqi Jing and Yanhe Li and Huolin L. Xin}, doi = {10.1002/anie.202424304}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424304}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An adhesive adaptation layer mitigates the interfacial instabilities of rigid polymer electrolyte}, volume = {64}, year = {2025}, }
• (2025). Tailoring one-dimensional assemblies of chiral bowl-shaped molecules with diverse enantiomers and polar column alignments. ANGEW, 64(20), e202424162. (www)

  @article{ , abstract = {Symmetry is an important factor in material design. Generally, it is difficult to quantitively discuss symmetry-property relations. Two materials only with symmetry differences are requisite to verify whether polar or nonpolar chiral systems are advantageous for a specific property/phenomenon, such as chirality-induced spin selectivity. However, it is difficult to selectively prepare materials having different symmetries without changing other physical properties. The current study successfully prepared seven exceptionally similar crystals with different symmetries in terms of polarity, chirality, and enantiomer alignments, which affords ideal materials for the abovementioned studies. Furthermore, we revealed a universal guiding principle on the self-assembly pattern of bowl-shaped molecules to predict the resultant assembled structures with the help of molecular dynamics simulations.}, archive = {J_ANGEW}, author = {Dan He and Barun Dhara and Cheng Zhang and Atsuko Nihonyanagi and Hiroyuki Inuzuka and Eiju Hara and Shunsuke Sato and Kiyohiro Adachi and Go Watanabe and Daisuke Hashizume and Kou Okuro and Daigo Miyajima}, doi = {10.1002/anie.202424162}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring one-dimensional assemblies of chiral bowl-shaped molecules with diverse enantiomers and polar column alignments}, volume = {64}, year = {2025}, }
• (2025). Activating La−O−Ni bridge in ordered macroporous interface for electrochemical urea wastewater purification. ANGEW, 64(20), e202424014. (www)

  @article{ , abstract = {Electrochemical treatment of urea wastewater purification significantly aids in environmental protection, but it remains a considerable challenge in designing high performance anode urea oxidation electrocatalysts. Herein, we report a La-induced three-dimensional ordered macroporous (3DOM) NiO heterostructure to improve Ni sites electron density for urea electrooxidation by activating the La−O−Ni bridge. This material demonstrated exceptional performance in a membrane electrode assembly (MEA) device, characterized by a low cell voltage (1.49 V @ 80 °C) and 280 h stability test at 1 A cm −2 current density (25 °C) and displayed promising efficiency in urea wastewater purification. Permeation experiments revealed the crucial role of 3DOM morphological in facilitating mass transfer processes. A high valence nickel mechanism (HNM) on the La−O−Ni bridge during catalysis was proposed, based on various in situ characterizations and theoretical calculations. Experimentally, in situ Raman and UV-vis spectra demonstrated that Ni active species Ni δ+ (δ≥3) promote urea oxidation kinetics, while in situ ATR-IR proved strong adsorption of C=O with Ni sites and the enhancement of urea N−H bonds cleavage, supporting the HNM. This work enables us to underscore the critical importance of La−O−Ni electron bridge with 3DOM architectures and promising contributions to urea wastewater purification.}, archive = {J_ANGEW}, author = {Xiaoyue Qiang and Yaxiong Yao and Jie Yin and Pengfei Da and Zhaori Mu and Kaier Shen and Yuanmiao Sun and Yunxiang Zhang and Peiqiong Li and Zhenglong Li and Pinxian Xi and Chun-Hua Yan}, doi = {10.1002/anie.202424014}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202424014}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activating La−O−Ni bridge in ordered macroporous interface for electrochemical urea wastewater purification}, volume = {64}, year = {2025}, }
• (2025). Coupling photocatalytic reduction and biosynthesis towards sustainable CO2 upcycling. ANGEW, 64(20), e202423995. (www)

  @article{ , abstract = {Upcycling carbon dioxide (CO 2 ) into long-chain compounds has attracted considerable attention with respect to mitigating environmental problems and obtaining value-added feedstocks, but remains a great challenge. Herein, we report a tandem photocatalysis-biosynthesis strategy for efficient CO 2 reduction to energy-rich sucrose or α-farnesene. Firstly, photocatalytic reduction of CO 2 to CH 4 was optimized over the transitional metal doped ZnO (M−ZnO). The as-prepared Ni−ZnO preferentially reduces CO 2 to CH 4 with a production rate of 1539.1 μmol g −1 h −1 and a selectivity of 90 %, owing to the unique interface structure (Zn δ + −O−Ni β + ). Subsequently, Methylomicrobium buryatense 5GB1C was genetically engineered to produce sucrose or α-farnesene using photocatalytically-obtained CH 4 as the sole carbon source, with a titer of 96.3 and 43.9 mg L −1 , respectively. This study provides a green, low-energy pathway for the synthesis of long-chain compounds from CO 2 as the carbon source, which sheds new light on tackling long-term energy demands and sustainable CO 2 upcycling.}, archive = {J_ANGEW}, author = {Mengjie Yu and Maolong Li and Xinzhe Zhang and Zhen Ge and Enze Xu and Lei Wang and Boyu Yin and Yibo Dou and Yusen Yang and Xin Zhang and Qiang Fei and Min Wei and Tianwei Tan}, doi = {10.1002/anie.202423995}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202423995}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coupling photocatalytic reduction and biosynthesis towards sustainable CO2 upcycling}, volume = {64}, year = {2025}, }
• (2025). Direct synthesis of polar-functionalized polyolefin elastomers. ANGEW, 64(20), e202423814. (www)

  @article{ , abstract = {Polyolefin elastomers (POEs) are widely used for many applications including plastic toughening and encapsulating photovoltaic modules. The introduction of polar groups into POEs improves their compatibility and adhesion with polar components, but it is challenging to prepare high-molecular-weight polar-functionalized POEs (P-POEs) via copolymerization. Here, we report a silane protection strategy to enable the production of P-POEs (including an ethylene-based P- E POE and a propylene-based P- P POE) with widely tunable 1-octene incorporation ratios (7.4–19.8 mol %), appropriate polar monomer incorporation ratios (0.7–2.7 mol %), melting points (63.8–99.8 °C), and high molecular weights (up to 43.8×10 4 g mol −1 ). This approach involved the early transition metal-catalyzed terpolymerization of ethylene or propylene, 1-octene, and protected polar monomers. This silane protection strategy is superior to the previously widely practiced aluminum-based protection strategies in terms of polymerization activity, polymer molecular weight, comonomer incorporation, and product processibility. Most importantly, the P-POE products exhibited excellent mechanical properties and elasticity and served as high-performance compatibilizers and adhesives to enhance the functional applications of POEs.}, archive = {J_ANGEW}, author = {Quan Wang and Min Chen and Chen Zou and Changle Chen}, doi = {10.1002/anie.202423814}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202423814}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct synthesis of polar-functionalized polyolefin elastomers}, volume = {64}, year = {2025}, }
• (2025). Enzyme surface residues direct encapsulation into Metal–Organic frameworks for performance regulation. ANGEW, 64(20), e202423741. (www)

  @article{ , abstract = {Herein, we highlight the role of nitrogen-enriched surface groups on proteins in directing topological transformations of metal–organic frameworks (MOFs). Using a modified-protein-directed MOFs template synthesis (mDTS) strategy, we demonstrate that these surface modifications on cytochrome c (Cyt c) selectively induce the formation of leaf-like zeolitic imidazolate frameworks (ZIF-L). This approach not only enables a structural transition from ZIF-8 to a more open ZIF-L framework but also substantially enhances the catalytic activity and loading of Cyt c beyond traditional immobilization methods. Adjusting the concentration of the surface modifier allows for precise tuning of the Cyt c activity, allowing optimal enzyme function at specific modifier levels. Furthermore, our results reveal that surface modifications of a variety of proteins can facilitate the formation of ZIF-L, emphasizing the broad applicability of the mDTS method. This approach offers significant promise for developing highly efficient protein-MOF composites, offering transformative potential for industrial catalysis and biotechnological applications.}, archive = {J_ANGEW}, author = {Mengyao Wu and Yuexin Du and Hui Xu and Xiehaoran Zhang and Jialong Ma and Ao Li and Lien-Yang Chou}, doi = {10.1002/anie.202423741}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202423741}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzyme surface residues direct encapsulation into Metal–Organic frameworks for performance regulation}, volume = {64}, year = {2025}, }
• (2025). Efficient generation of negative hydrogen with bimetallic-ternary-structured catalysts for nitrobenzene hydrogenation. ANGEW, 64(20), e202423626. (www)

  @article{ , abstract = {Transition metal-catalyzed transfer hydrogenation (TH) with in situ negative hydrogen (H − ) has received extensive attention as an alternative to conventional high-pressure hydrogenation processes. However, the insufficient activity of hydrogen production and unclear the conversion process of hydrogenation remain a great challenge. In this work, brand new bimetallic ternary-structured catalysts (Ru 1+n M 1 -TiO 2 , M=Co, Cu, Fe, Ni) were synthesized to efficiently generate H − donors from ammonia borane (AB, NH 3 BH 3 ) for nitrobenzene hydrogenation under moderate conditions. The Ru 1+n Co 1 -TiO 2 catalysts exhibited highest activity for hydrogen production form AB hydrolysis with a TOF value of 2716 min −1 . The Ru 1+n Co 1 -TiO 2 achieved >90 % yields within 3–4 hours in converting nitrobenzene to anilines using AB. Mechanistic studies revealed that the high hydrolysis activity was due to that the Ru SA and Co SA sites of the bimetallic-ternary-structured catalyst required the lowest energy for the activation of AB and H 2 O, respectively. Remarkably, the Co SA and Ru clusters exhibited an obvious synergistic effect in the TH process, which promoted the tandem hydrogenation of nitroaromatics. This work demonstrated an efficient approach to generate H − donor with bimetallic-ternary-structured catalysts in TH process and further provided new inspiration on the development of multifunctional catalysts.}, archive = {J_ANGEW}, author = {Ji Shen and Minhao Tang and Zuhao Shi and Shuyan Guan and Yijie Shi and Zechao Zhuang and Runze Li and Jiarui Yang and Daping He and Baozhong Liu and Yuhai Dou and Dingsheng Wang}, doi = {10.1002/anie.202423626}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202423626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient generation of negative hydrogen with bimetallic-ternary-structured catalysts for nitrobenzene hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Nanoconfinement-induced electrochemical ion-solvent cointercalation in pillared titanate host materials. ANGEW, 64(20), e202423593. (www)

  @article{ , abstract = {Electrochemical ion-solvent cointercalation reactions are an avenue to reach improved kinetics compared to the corresponding intercalation of desolvated ions. Here, we demonstrate the impact of different structural pillar molecules on the electrochemical Li + intercalation mechanism in expanded hydrogen titanate (HTO) electrode materials. We show that interlayer-expansion of HTO with organic pillars can enable cointercalation reactions. Their electrochemical reversibility is drastically improved when non-cross-linking pillars are employed that expand and separate the host material's individual layers, underlining the impact of the electrochemo-mechanics of the nanoconfined interlayer space. This pillared HTO structure results in an increased Li + storage capacity and reversibility compared to pristine HTO. We derive structural models of the pillared HTO host materials based on combined experiments and theoretical calculations, and employ electrochemical operando experiments to unambiguously demonstrate the nanoconfinement-induced cointercalation mechanism in pillared HTO electrode materials. The work demonstrates the potential of nanoconfined pillar molecules to modify host materials and enable highly reversible cointercalation reactions with improved capacity and kinetics.}, archive = {J_ANGEW}, author = {Mennatalla Elmanzalawy and Haohong Song and Maciej Tobis and Robert Leiter and Jaehoon Choi and Hyein Moon and Wan-Yu Tsai and De-en Jiang and Simon Fleischmann}, doi = {10.1002/anie.202423593}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202423593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanoconfinement-induced electrochemical ion-solvent cointercalation in pillared titanate host materials}, volume = {64}, year = {2025}, }
• (2025). Coordination topology design in anion-rich solvated electrolytes for high-voltage lithium metal batteries. ANGEW, 64(20), e202423439. (www)

  @article{ , abstract = {Electrolytes with anion-rich solvated structures are promising for high-voltage lithium metal batteries (LMBs) due to their good interfacial compatibility. Nevertheless, limited Li-ion transport of these electrolytes has hindered their high-rate application. Here we demonstrate that Li-ion transport in anion-rich solvated electrolytes could be facilitated by designing the coordination topology of anions in the solvation structure. Results show that, for a binary-anion electrolyte, equal-molar anions show the most expanded energy level distribution of solvation structures, thus reducing the Li-ion transport energy barrier, and resulting in a Li-ion conductivity even higher than that of the commercial carbonate electrolyte at a temperature range from −40 °C to 60 °C. More importantly, we identify a universal principle governing the Li-ion transport enhancement driven by anion configurations: only the combination of anions with multi-coordination sites shows facilitation in Li-ion transport, while the combination of centrosymmetric anions with the mono-coordination site harms it. The diversified anion-rich solvated structures also form stable interphases on the electrodes, enabling long-term cycling of 4.5 V LMBs at a high current density of 3.78 mA cm −2 . Overall, our findings shine new light on developing practical electrolytes for energy-dense LMBs.}, archive = {J_ANGEW}, author = {Ruowei Yi and Kui Xu and Wenlong Zhao and Zixu Ren and Qingyu Dong and Hui Shao and Yanbin Shen and Liwei Chen}, doi = {10.1002/anie.202423439}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202423439}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coordination topology design in anion-rich solvated electrolytes for high-voltage lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Dual breaking of electron cloud and space structure symmetry induced microscopic split-phase interface for high-rate and long-term aqueous zinc batteries. ANGEW, 64(20), e202423138. (www)

  @article{ , abstract = {Weak dipole interactions between highly symmetric H 2 O molecules and SO 4 2− species are the root cause of unstable electric double layer (EDL), which triggers the hydrogen evolution reaction and Zn dendrite formation, significantly impeding the commercialization of aqueous zinc-ion batteries. Herein, we designed a microscopic split-phase interface (MSPI) by dual breaking of electron cloud and space structure symmetry to suppress interfacial side reactions and achieve uniform Zn deposition. The structurally asymmetric methylurea (MU) molecules possess both hydrophobic methyl and hydrophilic amino groups, which disrupt the continuity of H-bonding network and the aggregation state of H 2 O molecules, resulting in peculiar nanoscale core–shell-like clusters. Such a unique structure further evolves into MSPI at the electrode-electrolyte interface, ensuring a continuously stable EDL. The DRT analysis and MD simulation confirmed that MSPI structure is composed of the outer H 2 O layer and the inner MU layer, which greatly suppress the activity of H 2 O molecules and accelerate Zn 2+ migration. Consequently, the formulated electrolyte exhibited remarkable cycle reversibility over 1500 h at a high current density of 20 mA⋅cm −2 , achieving a record-high cumulative capacity of 30 Ah⋅cm −2 . Additionally, its feasibility was demonstrated by coupling with the I 2 @AC cathode, achieving an impressive 28,000 cycles at 10 A⋅g −1 .}, archive = {J_ANGEW}, author = {Kai Bai and Xiangwen Wang and Jiaqi Ke and Zhipeng Wen and Zuyang Hu and Wencheng Du and Yufei Zhang and Minghui Ye and Yongchao Tang and Xiaoqing Liu and Li Niu and Cheng Chao Li}, doi = {10.1002/anie.202423138}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202423138}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual breaking of electron cloud and space structure symmetry induced microscopic split-phase interface for high-rate and long-term aqueous zinc batteries}, volume = {64}, year = {2025}, }
• (2025). A multifunctional molecular modulated strategy featuring novel li+ transport centers and Li2O-rich SEI layer for high-performance all-solid-state lithium metal batteries. ANGEW, 64(20), e202422942. (www)

  @article{ , abstract = {The poor ionic conductivity and interfacial instability severely limit the application of polyethylene oxide (PEO)-based polymer electrolytes. In this work, we introduce a multifunctional molecular modulated strategy using coumarin, which simultaneously boosts the ionic conductivity and interfacial stability of PEO-coumarin (PLC) membrane. Unlike conventional additives that diminish PEO's crystallinity, coumarin, with its higher Li + adsorption energy and stronger dipole moments, acts as a novel ‘carrier’ for Li + without compromising the mechanical properties of the PEO matrix. Its synergistic effect with PEO creates a more efficient Li + transport pathway to achieve a high ionic conductivity of 1.1 mS cm −1 at 60 °C. Simultaneously, coumarin as a sacrificial agent by utilizing its carbonyl group, preferentially reacts with lithium metal to prevent the decomposition of PEO and lithium salts. Furthermore, coumarin acts as an in situ Li 2 O-inducer, facilitating the formation of a dense Li 2 O-rich solid electrolyte interphase (SEI) layer with faster ion diffusion kinetics at the interface. The beneficial effect of the multifunctional molecular engineering design enables the Li|PLC|Li symmetric cell to cycle over 5000 h and allows the Li|PLC|LiFePO 4 battery to deliver a high initial discharge capacity of 161.9 mAh g −1 with a capacity retention ratio of 93 % after 550 cycles at 0.5 C.}, archive = {J_ANGEW}, author = {Shufen Wu and Nian Zhang and Jintao Du and Feifan Tao and Wenjun Ma and Xinyuan Yin and Yibo Wang and Hui Zhang and Pengfei Yu and Xuefei Feng and Xiaosong Liu}, doi = {10.1002/anie.202422942}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202422942}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A multifunctional molecular modulated strategy featuring novel li+ transport centers and Li2O-rich SEI layer for high-performance all-solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Multisite cross-linked ligand suppressing ion migration for efficient and stable CsPbBr3 perovskite quantum dot-based light-emitting diodes. ANGEW, 64(20), e202422823. (www)

  @article{ , abstract = {Perovskite quantum dots (QDs), as promisingly solution-processed emitters, have produced impressive external quantum efficiencies (EQEs) in light-emitting diodes (LEDs). However, the operational stability of perovskite QD-based LEDs (QLEDs) is still limited by severe ion migration. Here, we propose a multisite cross-linked ligand strategy using α -lipoic acid (LA) molecules to simultaneously reduce non-radiative recombination and suppress ion migration in QLEDs. Meanwhile, the introduction of cross-linked LA ligands can reduce the roughness and contact potential difference variation of QD films, which facilitates the injection and recombination of carriers in devices. As a result, the colour-saturated green CsPbBr 3 -based QLED deliver a maximum EQE of 25.6 % together with an operational lifetime of 1340 h at an initial luminance of 100 cd m −2 , representing the most efficient and stable perovskite LEDs based on cross-linked QDs. The improvement in device stability is attributed to the reduced ion migration, which is confirmed by analyzing the current behavior of QLEDs and time-of-flight secondary-ion mass spectrometry. This study provides a facile strategy for mitigating halide ion migration in perovskite fields toward more efficient and stable perovskite QLEDs.}, archive = {J_ANGEW}, author = {Yuzhu Xu and Weichuang Guo and Jisong Yao and Leimeng Xu and Jindi Wang and Zhi Yang and Shalong Wang and Jizhong Song}, doi = {10.1002/anie.202422823}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202422823}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multisite cross-linked ligand suppressing ion migration for efficient and stable CsPbBr3 perovskite quantum dot-based light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Pressure-driven reactivity in dense methane-nitrogen mixtures. ANGEW, 64(20), e202422710. (www)

  @article{ , abstract = {Carbon, nitrogen, and hydrogen are among the most abundant elements in the solar system, and our understanding of their interactions is fundamental to prebiotic chemistry. CH 4 and N 2 are the simplest archetypical molecules formed by these elements and are both markedly stable under extremes of pressure. Through a series of diamond anvil cell experiments supported by density functional theory calculations, we observe diverse compound formation and reactivity in the CH 4 -N 2 binary system at high pressure. Above 7 GPa two concentration-dependent molecular compounds emerge, (CH 4 ) 5 N 2 and (CH 4 ) 7 (N 2 ) 8 , held together by weak van der Waals interactions. Strikingly, further compression at room temperature irreversibly breaks the N 2 triple bond, inducing the dissociation of CH 4 above 140 GPa, with the near-quenched samples revealing distinct spectroscopic signatures of strong covalently bonded C−N−H networks. High temperatures vastly reduce the required pressure to promote the reactivity between CH 4 and N 2 , with NH 3 forming together with longer-chain hydrocarbons at 14 GPa and 670 K, further decomposing into powdered diamond when temperatures exceed 1200 K. These results exemplify how pressure-driven chemistry can cause unexpected complexity in the most simple molecular precursors.}, archive = {J_ANGEW}, author = {Hannah A. Shuttleworth and Mikhail A. Kuzovnikov and Lewis J. Conway and Huixin Hu and Jinwei Yan and Samuel Gallego-Parra and Israel Osmond and Tomas Marqueño and Michael Hanfland and Dominique Laniel and Eugene Gregoryanz and Andreas Hermann and Miriam Peña-Alvarez and Ross T. Howie}, doi = {10.1002/anie.202422710}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202422710}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pressure-driven reactivity in dense methane-nitrogen mixtures}, volume = {64}, year = {2025}, }
• (2025). Visible light-driven acetaldehyde production from CO2 and H2O via synergistic vacancies and atomically dispersed cu sites. ANGEW, 64(20), e202422667. (www)

  @article{ , abstract = {Acetaldehyde (CH 3 CHO) is of great industrial importance and serves as a key intermediate in various organic transformations. Photocatalytic production of acetaldehyde from CO 2 represents a sustainable route compared to conventional oxidation processes. However, current photocatalytic systems often face challenges, including limited product selectivity and dependence on sacrificial reagents. Here, we present a Cd 0.6 Zn 0.4 S (CZS) photocatalyst co-modified with sulfur vacancies and atomically dispersed Cu (Cu/CZS−Vs) for the efficient conversion of CO 2 to acetaldehyde. Charge density analysis reveals that sulfur vacancies induce charge accumulation around the adjacent metal atoms, creating active sites that strongly anchor CO 2 and H + , thereby promoting CO 2 conversion while suppressing the competing hydrogen evolution reaction. The atomically dispersed Cu sites facilitate the conversion of key intermediates (i.e., *CHO and *CO) to the crucial C 2 intermediate *OCCHO, which can subsequently be converted to acetaldehyde. As a result, this catalyst achieves an acetaldehyde yield of 121.5 μmol g −1 h −1 with a selectivity of ca. 80 % via photocatalytic CO 2 conversion in the absence of sacrificial agents, along with a quantum efficiency of ca. 0.53 % at 400 nm, underscoring its potential for practical CO 2 conversion applications. These results are expected to pave the way for future developments in green chemical processes.}, archive = {J_ANGEW}, author = {Jian Lei and Zhongliao Wang and Jinquan Huo and Shuaikang Sang and Chao Zhang and Enquan Zhu and Tingting Kong and Ferdi Karadas and Jingxiang Low and Yujie Xiong}, doi = {10.1002/anie.202422667}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202422667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible light-driven acetaldehyde production from CO2 and H2O via synergistic vacancies and atomically dispersed cu sites}, volume = {64}, year = {2025}, }
• (2025). Modulating adsorption behavior by single-site pt on RuO2 for efficient electrosynthesis of glycolic acid from plastic wastes. ANGEW, 64(20), e202422183. (www)

  @article{ , abstract = {Electrochemical upcycling of polyethylene terephthalate (PET) wastes into valuable glycolic acid (GA) is an ideal solution for resource utilization. However, simultaneously achieving high activity and selectivity remains challenging due to the over-oxidation and C−C cleavage during ethylene glycol (EG) oxidation in PET hydrolysate. Herein, we develop an atomically isolated Pt on RuO 2 (Pt 1 /RuO 2 ) catalyst composed of high-density Pt−Ru interfaces that ensure single-site adsorption of EG, enrich surface *OH coverage and weaken *CO−CH 2 OH intermediate adsorption, thereby synergistically promoting GA generation. Specifically, Pt 1 /RuO 2 delivers a remarkable mass activity of 8.09 A/mg Pt , as well as a high GA Faradaic efficiency (95.3 %) and selectivity (96.9 %). Under membrane electrode assembly conditions, Pt 1 /RuO 2 realizes a stable electrolysis over 500 h at 6 A with a GA yield rate of 4.06 g h −1 . In-depth theoretical and in situ spectroscopic investigations reveal the synergy between isolated Pt and oxophilic RuO 2 plays a crucial role in high-efficiency EG-to-GA conversion. This study offers valuable insights for the rational design of advanced catalysts for GA synthesis from PET wastes via a single-site doped bimetallic strategy.}, archive = {J_ANGEW}, author = {Fulai Liu and Jingtao Zhou and Xutao Gao and Rui Shi and Zhengxiao Guo and Edmund C. M. Tse and Yong Chen}, doi = {10.1002/anie.202422183}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202422183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating adsorption behavior by single-site pt on RuO2 for efficient electrosynthesis of glycolic acid from plastic wastes}, volume = {64}, year = {2025}, }
• (2025). Formation of the diketopiperazine moiety by a distinct condensation-like domain in hangtaimycin biosynthesis. ANGEW, 64(20), e202421950. (www)

  @article{ , abstract = {Non-ribosomal peptide synthetases (NRPSs) are key enzymes in pharmaceutical synthesis, with condensation (C) domains catalyzing amide bond formation between aminoacyl substrates. However, recent research has elucidated that the catalytic capabilities of C domains extend beyond the traditional formation of peptide bonds. In this study, we elucidate the cyclization mechanism of the NRPS-derived natural products hangtaimycin (HTM), characterized by the formation of a 2,5-diketopiperazine (DKP) moiety which involves an intramolecular vinylamide-mediated nucleophilic attack instead of an N-terminal amino group. This cyclization is catalyzed by a terminal condensation-like (C T ) domain within the NRPS enzyme HtmB2. We investigated the evolutionary specificity of the HtmB2-C T within Streptomyces spectabilis CCTCC M2017417. Employing a multidisciplinary analytical approach, we have delineated the molecular underpinnings of DKP formation within the HTM biosynthesis. This process is facilitated by residue R2776, which modulates the formation of reactive species and stabilizes the amidate through electrostatic interactions. Besides, we found a positive correlation between the alkaline strength of the residue at position 2776 and the activity of HtmB2-C T . Our study elucidates the formation mechanism of DKPs in NRPS-derived natural products, thereby bridging a critical gap in the structural and mechanistic understanding of this field.}, archive = {J_ANGEW}, author = {Qing Mei and Shijuan Wu and Minghe Luo and Shunjia Ji and Jiayi Guo and Chuan Dong and Guo Sun and Jian Wang and Zixin Deng and Yi-Lei Zhao and Zhengyu Zhang and Yuhui Sun}, doi = {10.1002/anie.202421950}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202421950}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formation of the diketopiperazine moiety by a distinct condensation-like domain in hangtaimycin biosynthesis}, volume = {64}, year = {2025}, }
• (2025). Diacylation of peptides enables the construction of functional vesicles for drug-carrying liposomes. ANGEW, 64(20), e202421932. (www)

  @article{ , abstract = {Membrane-forming phospholipids are generated in cells by enzymatic diacylation of non-amphiphilic polar head groups. Analogous non-enzymatic processes may have been relevant at the origin of life and could have practical utility in membrane synthesis. However, aqueous head group diacylation is challenging in the absence of enzymes. The use of charged peptides instead of canonical phospholipid head groups offers advantages with respect to ease of acylation and chemical diversity. Here we demonstrate that native chemical ligation (NCL) enables in situ synthesis of diacylated lipopeptides (D-ALPs), which spontaneously self-assemble into micron-sized vesicles resembling cellular membranes. Diacylation occurs between non-amphiphilic peptides possessing an N -terminal cysteine, and acyl thioesters. Peptide head groups endow unique membrane functions, which is demonstrated by incorporation of an arginine-glycine-aspartic acid (RGD) motif, resulting in vesicle targeting to α v β 3 integrin-overexpressing cancer cells. The biocompatibility and functional group programmability of D-ALPs supports their broad utility as membrane mimetics.}, archive = {J_ANGEW}, author = {Christy J. Cho and Sangyoon Kang and Conrado Pedebos and Syma Khalid and Roberto J. Brea and Neal K. Devaraj}, doi = {10.1002/anie.202421932}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202421932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diacylation of peptides enables the construction of functional vesicles for drug-carrying liposomes}, volume = {64}, year = {2025}, }
• (2025). Profiling allosteric modulators of CB1R with an allosteric fluoroprobe. ANGEW, 64(20), e202421885. (www)

  @article{ , abstract = {Allosteric modulation of cannabinoid receptor type 1 (CB 1 R) offers a promising alternative to conventional therapeutic approaches using orthosteric ligands (OLs). Currently, CB 1 R allosteric modulators (AMs) are characterized based on their ability to modulate binding or functional response of OLs, preventing isolation of individual contributions by allosteric and orthosteric ligands. Herein, we develop the first allosteric fluoroprobe and attendant FRET-based assay allowing for the direct profiling of CB 1 R AMs without coincubation with an OL. Our allosteric tracer enables differentiation of allosteric and orthosteric ligands as well as their pharmacological profiling at CB 1 R. The utility of this work is highlighted by addressing ambiguities surrounding the binding of cannabidiol (CBD). CBD was found to interact with both allosteric and orthosteric sites of CB 1 R with comparable affinity (p K i =5.34 and 5.67, respectively).}, archive = {J_ANGEW}, author = {Miroslav Kosar and Themiya Perera and Rudolf L. Z. Ganzoni and Roman C. Sarott and Leire Borrega-Roman and Rosa Maria Vitale and Alessia Ligresti and Arne C. Rufer and Wolfgang Guba and Uwe Grether and Erick M. Carreira and Dmitry B. Veprintsev and David A. Sykes}, doi = {10.1002/anie.202421885}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202421885}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Profiling allosteric modulators of CB1R with an allosteric fluoroprobe}, volume = {64}, year = {2025}, }
• (2025). 6H-intermediate phase enabled slow crystal growth of tin halide perovskites for indoor photovoltaics. ANGEW, 64(20), e202421547. (www)

  @article{ , abstract = {The rapid expansion of Big Data and Internet of Things (IoT) has driven significant advancements in indoor photovoltaics (IPVs), which provide power to wireless IoT devices. Tin halide perovskites (THPs) have garnered significant attention for IPVs due to their excellent optoelectronic properties without the environmental risks of lead exposure. However, THPs face challenges in controlling their fast crystallization process. Here, we introduce a novel approach to precisely control the crystallization kinetics of FASnI 2 Br perovskite via the formation of the 6H-intermediate phase, supported by the mesomeric (+M) interaction effect of 4-aminopyridine hydrochloride (4APCl) in the perovskite precursor. The grazing-incidence wide-angle X-ray scattering measurements indicated the formation of 6H-intermediate phase for the FASnI 2 Br-4APCl perovskite during the crystallization process. The in situ ultraviolet-visible absorption spectroscopy during the spin coating and annealing process confirmed the reduction of crystal growth rate after the 6H-intermediate phase formation. Thus, high-quality perovskite films were obtained with reduced defects. The resulting IPVs achieved an efficiency of 21.55 % under indoor illumination at 1000 lux, exceeding all types of lead-free perovskite IPVs.}, archive = {J_ANGEW}, author = {Muhammad Abdel-Shakour and Junfang Wang and Junjie Huang and Zhen Gao and Yongle Pan and Xiangyue Meng}, doi = {10.1002/anie.202421547}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202421547}, shortjournal = {Angew. Chem. Int. Edit.}, title = {6H-intermediate phase enabled slow crystal growth of tin halide perovskites for indoor photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Sulfur conversion to donor-acceptor ladder polymer networks through mechanochemical nucleophilic aromatic substitution for efficient CO2 photoreduction. ANGEW, 64(20), e202419108. (www)

  @article{ , abstract = {The development of synthetic methods capable of converting elemental sulfur into conjugated porous sulfur-rich polymers remains a great challenge, although direct utilization of this readily available feedstock can significantly enrich its uses and circumvent environmental problems during sulfur storage. We report herein mechanochemical (MC) nucleophilic aromatic substitution (S N Ar) that enables sulfur conversion into thianthrene-bridged porous ladder polymer networks with dense donor-acceptor (D−A) molecular junctions. We demonstrate that the key lies in the generation of bent thianthrene units through a solid-state ball-milling condensation reaction between 1,2-dihaloarenes and elemental sulfur. We also show that the assembling of D−A structural motifs into porous networks affords efficient visible-light-driven photocatalytic reduction of carbon dioxide (CO 2 ) with water (H 2 O) vapor, in the absence of any additional photosensitizer, sacrificial agents or cocatalysts. Exceptional photoinduced charge separation along with boosted exciton dissociation results in a high-performance of carbon monoxide (CO) production rate of 306.1 μmol g −1 h −1 with near 100 % CO selectivity, which is accompanied by H 2 O oxidation to O 2 , as confirmed by both experimental and theoretical results. We anticipate this novel MC S N Ar approach will advance processing techniques for direct sulfur utilization and facilitate new possibilities for the synthesis of D−A ladder polymer networks with promising potential in photocatalysis.}, archive = {J_ANGEW}, author = {Na Yang and Zi-Jian Zhou and Xiang Zhu and Jiwei Wu and Yifan Zhang and Tao Wang and Xin-Ping Wu and Chengcheng Tian and Xia Jiang and Sheng Dai}, doi = {10.1002/anie.202419108}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202419108}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sulfur conversion to donor-acceptor ladder polymer networks through mechanochemical nucleophilic aromatic substitution for efficient CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Sustainable pathways for the synthesis of calcium sulfate hemihydrate. ANGEW, 64(20), e202415161. (www)

  @article{ , abstract = {Calcium sulfate, and especially its hemihydrate form (bassanite), is crucial in the construction industry, primarily used as a hydraulic binder in cements, mortars, and wallboards. Because of the rapid transformation of bassanite into thermodynamically stable gypsum (calcium sulfate dihydrate) upon contact with water, natural deposits are scarce, rendering it one of the most extensively produced inorganic materials worldwide. Currently, bassanite is derived from mined or waste gypsum through a thermal dehydration process, which is energy-intensive and costly. As sustainability has become a key target for industrial processes and products, a series of studies aiming to increase the energy efficiency and reduce the carbon footprint of bassanite production was published recently. Two primary approaches are pursued: conversion of gypsum and direct precipitation of bassanite from solution. In both cases, organic solvents, (specific) additives and/or elevated temperatures have been used to control the activity/availability of water in the reaction medium and thus direct phase selection towards bassanite. This review offers a comprehensive overview of alternative bassanite production methods, critically examining their benefits, potential downsides, and overall impact on the sustainability of industrial-scale use.}, archive = {J_ANGEW}, author = {Selina Reigl and Alexander E. S. Van Driessche and Tomasz M. Stawski and Sebastian Koltzenburg and Werner Kunz and Matthias Kellermeier}, doi = {10.1002/anie.202415161}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {20}, pages = {e202415161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sustainable pathways for the synthesis of calcium sulfate hemihydrate}, volume = {64}, year = {2025}, }
• (2025). Back cover: Simultaneous electrochemical upgrading of biomass and CO2 utilization using Fe/Ni-derived carbon nanotubes derived from CO2 (Angew. chem. int. ed. 19/2025). ANGEW, 64(19), e202508905. (www)

  @article{ , archive = {J_ANGEW}, author = {Anousha Sohail and Watinee Nunthakitgoson and Sorasak Klinyod and Anawat Thivasasith and Anittha Prasertsab and Peeranat Chaipornchalerm and Warot Prasanseang and Wanmai Srisuwanno and Poobodin Mano and Somlak Ittisanronnachai and Supawadee Namuangruk and Chularat Wattanakit}, doi = {10.1002/anie.202508905}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202508905}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Simultaneous electrochemical upgrading of biomass and CO2 utilization using Fe/Ni-derived carbon nanotubes derived from CO2 (Angew. chem. int. ed. 19/2025)}, volume = {64}, year = {2025}, }
• (2025). Front cover: Spiro-driven ferroelectric coordination polymer exhibiting distinct phase transitions under thermal and pressure stimuli (Angew. chem. int. ed. 19/2025). ANGEW, 64(19), e202508902. (www)

  @article{ , archive = {J_ANGEW}, author = {Zi-Yi Du and Miao Xie and Wenbo Qiu and Ding-Chong Han and Shi-Yong Zhang and Ying Zeng and Weizhao Cai and Takayoshi Nakamura and Rui-Kang Huang and Chun-Ting He}, doi = {10.1002/anie.202508902}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202508902}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Front cover: Spiro-driven ferroelectric coordination polymer exhibiting distinct phase transitions under thermal and pressure stimuli (Angew. chem. int. ed. 19/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Readily visualized perfluorooctanoic acid detection using a small molecule chemosensor (Angew. chem. int. ed. 19/2025). ANGEW, 64(19), e202508473. (www)

  @article{ , archive = {J_ANGEW}, author = {Yu-Dong Yang and Qian Zhang and Xingchen Jin and Calvin V. Chau and Jian Yang and Graeme Henkelman and Xiaodong Chi and Han-Yuan Gong and Richard J. Hooley and Jonathan L. Sessler}, doi = {10.1002/anie.202508473}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202508473}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Readily visualized perfluorooctanoic acid detection using a small molecule chemosensor (Angew. chem. int. ed. 19/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Chemical process development in the pharmaceutical industry in europe: Insights and perspectives from industry scientists (Angew. chem. int. ed. 19/2025). ANGEW, 64(19), e202505858. (www)

  @article{ , archive = {J_ANGEW}, author = {Joachim Krueger and André P. Dieskau and Jorma Hassfeld and Joerg Gries and Oliver Block and Hilmar Weinmann and Daniel Kaufmann and Stefan Hildbrand and Volker Kraft and Robert Moeckel and Juan R. Dehli and Ulrich Scholz and Carl Friedrich Nising}, doi = {10.1002/anie.202505858}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202505858}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Chemical process development in the pharmaceutical industry in europe: Insights and perspectives from industry scientists (Angew. chem. int. ed. 19/2025)}, volume = {64}, year = {2025}, }
• (2025). Guillaume de bo. ANGEW, 64(19), e202505481. (www)

  @article{ , archive = {J_ANGEW}, author = {Guillaume De Bo}, doi = {10.1002/anie.202505481}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202505481}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Guillaume de bo}, volume = {64}, year = {2025}, }
• (2025). Péter Ábrányi-balogh. ANGEW, 64(19), e202505411. (www)

  @article{ , archive = {J_ANGEW}, author = {Péter Ábrányi-Balogh}, doi = {10.1002/anie.202505411}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202505411}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Péter Ábrányi-balogh}, volume = {64}, year = {2025}, }
• (2025). Iván lavandera garcía (1976–2025): Advancing biocatalysis with passion. ANGEW, 64(19), e202504745. (www)

  @article{ , archive = {J_ANGEW}, author = {Fabricio R. Bisogno and Gonzalo de Gonzalo and Vicente Gotor-Fernández and Mélanie Hall and Wolfgang Kroutil and Bettina Nestl and Caroline E. Paul}, doi = {10.1002/anie.202504745}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202504745}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iván lavandera garcía (1976–2025): Advancing biocatalysis with passion}, volume = {64}, year = {2025}, }
• (2025). Redox-activated near Infrared/Shortwave infrared emissive chromophores: Synthesis of triphenylamine-appended pyrazinacenes. ANGEW, 64(19), e202504564. (www)

  @article{ , abstract = {Organic dyes showing absorbance and fluorescence in the near infrared and short-wave infrared regions are attractive for a variety of applications. Redox-coupled reversible switching of absorbance or fluorescence implies enhanced functionality of such dyes, especially where large changes in photophysical properties across the redox process can be realized. Here, the synthesis of two new pyrazinacenes containing four and five fused pyrazine units, appended with electron-donor triphenylamine groups, and redox-coupled switching of their photophysical properties is reported. In their reduced state, the compounds show absorbance and fluorescence in the visible region. Reversible shifts in absorbance and fluorescence from the visible to the near infrared or even short-wave infrared regions are observed upon chemical and electrochemical oxidations. Such large redox-coupled shifts in photophysical properties are unprecedented for a redox process that affects only a single, six-membered ring in which both reduced and oxidized states consist of neutral, closed-shell species. The compounds show high fluorescence quantum yields in their reduced states, and oxidized species show fluorescence quantum yields that compare well with existing near infrared and short-wave infrared active fluorescent dyes.}, archive = {J_ANGEW}, author = {Gary J. Richards and Kazushi Nakada and Keita Aoki and Tomoki Jitsukata and Kana Hashimoto and Toshiki Tajima and Ryusuke Mizoguchi and Ayumi Ishii and Jonathan P. Hill and Akiko Hori}, doi = {10.1002/anie.202504564}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202504564}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-activated near Infrared/Shortwave infrared emissive chromophores: Synthesis of triphenylamine-appended pyrazinacenes}, volume = {64}, year = {2025}, }
• (2025). Engineered polymeric microspheres with synergistic hydrogen-bonding nanotraps and multisite adsorption for ultrafast herbicide decontamination. ANGEW, 64(19), e202504349. (www)

  @article{ , abstract = {The ultrafast removal of trace herbicides like paraquat (PQ) and diquat (DQ) from water is urgent yet challenging due to their highwater stability and strong-binding properties. Here, efficient PQ and DQ removal based on hydrogen-bonding nanotraps dominant multisite adsorption were developed. Two crosslinked polymeric microspheres, β CD-PF and γ CD-PF, were synthesized from cyclodextrins (CDs) and hexafluorocyclotriphosphazene (HFP). The γ CD-PF microsphere with sufficient hydrogen-bonding nanotraps on the pore surface prompts adsorption kinetics constants of PQ and DQ up to 127.09 and 192.64 g mg −1 min −1 , achieving 99% removal efficiency for PQ and DQ within 5 s. γ CD-PF exhibits exceptional selectivity for PQ and DQ over larger competing dyes. Importantly, trace PQ (1 ppm) can be effectively treated with γ CD-PF to achieve a concentration far below the US Environmental Protection Agency (EPA) standard (0.003 ppm) within 30 s. The ultrafast adsorption is driven by a multisite mechanism: electrostatic and π–π interactions from HFP promote adsorbate accumulation on the CD surface, while the high-density hydrogen-bonding nanotraps in γ CD-PF enhance hydrogen bond strength, enabling rapid capture. This work provides a valuable strategy for designing ultrafast adsorbents for effective herbicide removal from water.}, archive = {J_ANGEW}, author = {Jicai Jiang and Haibo Wan and Jinchang Zhang and Shuai Shi and Yaru Wang and Huilong Dong and Dongyun Chen and Kin Liao and Qingfeng Xu and Jianmei Lu}, doi = {10.1002/anie.202504349}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202504349}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered polymeric microspheres with synergistic hydrogen-bonding nanotraps and multisite adsorption for ultrafast herbicide decontamination}, volume = {64}, year = {2025}, }
• (2025). Iron single-atom based double-reaction-center catalysis triggers internal-driven and external-driven pathways for green fenton-like chemistry. ANGEW, 64(19), e202503995. (www)

  @article{ , abstract = {Double-reaction-centers (DRCs) Fenton-like chemistry with low or zero oxidant addition has garnered increasing attentions due to their alignment with the principles of green and sustainable development. However, the regulation of such processes remains a significant challenge, primarily due to deficiencies in the microscopic interpretation of their electron migration mechanisms operating with low or zero oxidant addition. In this work, iron single-atom DRCs catalyst (Fe/N-SAC) was prepared for internal-driven system (zero oxidant addition) and external-driven system (low peroxymonosulfate [PMS] addition). Results indicated the absence of dissolved oxygen activation in the PMS-zreo Fe/N-SAC system, and the iron single atoms in the Fe/N-SAC acted as the predominate electron acceptors to extract the electrons from the electron-donating pollutants with iron valence decreasing from +2.37 to +2.07 and they could also be recovered under O 2 atmosphere. In contrast, the electrons from the pollutants could be transferred to both PMS and iron atoms in the external-driven Fe/N-SAC/PMS system involving both predominant electron transfer process (ETP) and iron internal-driven. Furthermore, two experimental devices based on core mechanisms of internal-driven and external-driven systems were designed to achieve long-term operation. These studies will complement the core catalytic mechanisms and module applications of internal-driven and external-driven DRCs systems.}, archive = {J_ANGEW}, author = {Qingbai Tian and Jiale Chang and Xiaoming Peng and Longlong Geng and Baoyu Gao and Qian Li and Yue Gao and Xing Xu}, doi = {10.1002/anie.202503995}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503995}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron single-atom based double-reaction-center catalysis triggers internal-driven and external-driven pathways for green fenton-like chemistry}, volume = {64}, year = {2025}, }
• (2025). Hybrid linking sites constructed non-fully conjugated asymmetric dimerized giant molecule acceptors for organic solar cells with an efficiency of ≈20%. ANGEW, 64(19), e202503721. (www)

  @article{ , abstract = {Linking-site engineering, used to graft two or more monomers, is crucial for achieving high-performance Y-series giant molecule acceptors (Y-GMAs). However, the reported Y-GMAs all use a single-typed linking site, making it difficult to finely-tune their optoelectronic properties. Herein, we develop a non-fully conjugated Y-GMA (named 2Y-we), with hybrid linking sites at the wing and end-group of monomers, to combine the respective advantages of the wing and end-group site linked counterparts. Compared to its parental monomer, 2Y-we shows different intermolecular interactions, crystallinity, packing, and glass transition temperature, allowing optimized active layer morphology (including appropriate phase separation and ordered molecular packing) and stability. Consequently, the D18/2Y-we-based organic solar cells (OSCs) obtain an improved power-conversion-efficiency (PCE) of 17.4% with both higher open-circuit voltage ( V OC ) and short-circuit current density ( J SC ), due to the reduced energy loss and efficient exciton dissociation. Inspired by its high V OC × J SC , 2Y-we is introduced into D18:L8-BO to fabricate ternary devices. Thanks to the further optimized morphology and improved charge transport, the ternary OSCs achieve a superior PCE of 19.9%, which is the highest value among the reported nonfully conjugated Y-GMAs. Our developed hybrid linking-site engineering for constructing high-performance Y-GMAs offers an approach to boost device efficiency.}, archive = {J_ANGEW}, author = {Han Liu and Luting Tang and Tengfei Li and Fan Yi and Wenyan Su and Kai Xiang and Bitao Dong and Zefan Yao and Ke Wang and Tianyu Hu and Zhaozhao Bi and Hairui Bai and Jianhua Chen and Xunchang Wang and Yuhang Liu and Ruijie Ma and Manjun Xiao and Wei Ma and Qunping Fan}, doi = {10.1002/anie.202503721}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503721}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hybrid linking sites constructed non-fully conjugated asymmetric dimerized giant molecule acceptors for organic solar cells with an efficiency of ≈20%}, volume = {64}, year = {2025}, }
• (2025). Polyarylmethylpiperidinium (PAMP) for next generation anion exchange membranes. ANGEW, 64(19), e202503715. (www)

  @article{ , abstract = {Terawatt-scale hydrogen production using anion exchange membrane water electrolyzers (AEM-WEs) requires the development of facilely prepared, alkali-stable, and high-performance anion exchange membranes (AEMs). State-of-the-art polyarylpiperidinium AEMs fail to match the alkaline stability of piperidinium due to conformational deformation caused by the stiff cardo structure. Herein, polyarylmethylpiperidinium (PAMP) AEM with pendant structure is constructed by utilizing 4-formylpiperidine as a functional monomer. The inclusion of an aldehyde group in the synthesis enhances polymerization reactivity, reduces the amount of superacid required, and ensures that the piperidinium is suspended from the ether-free polymer backbone. The accelerated aging analysis demonstrates that the pendant structure of piperidinium effectively suppresses the Hofmann elimination, resulting in PAMP AEM with exceptional alkali stability, surpassing that of the commercial PiperION-A40. Most importantly, when assembled with non-noble metal OER/HER catalysts, the related AEM-WE achieves a remarkably high transient current density of 7.35 A cm −2 (@2 V, 80 °C, 1 m KOH). Moreover, the AEM-WE can operate stably at industrial current density over 1500 h (≈1.70 V at 1.0 A cm −2 ).}, archive = {J_ANGEW}, author = {Liqiang Yin and Rong Ren and Lanlan He and Husileng Lee and Qihang Zhang and Guoheng Ding and Linqin Wang and Licheng Sun}, doi = {10.1002/anie.202503715}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503715}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyarylmethylpiperidinium (PAMP) for next generation anion exchange membranes}, volume = {64}, year = {2025}, }
• (2025). Steering the product selectivity of CO2 electroreduction by single atom switching in isostructural copper nanocluster catalysts. ANGEW, 64(19), e202503417. (www)

  @article{ , abstract = {Even single atom manipulation can cause drastic changes in catalytic activity and selectivity, especially in atomic-level catalysts. However, it is challenging to accurately elucidate the influence of specific atoms on performance due to the intertwined factors in catalysts. Atomically precise isostructural nanoclusters (NCs) can serve as ideal platforms to uncover the impact of individual atoms on catalytic properties. Herein, a pair of isostructural Cu NCs ([Cu 13 (SC 6 H 3 F 2 ) 3 (P(PhF) 3 ) 7 H 10 ] 0 and [Cu 14 (SC 6 H 3 F 2 ) 3 (P(PhF) 3 ) 8 H 10 ] + namely as Cu 13 and Cu 14 ) were synthesized. In the electrochemical CO 2 reduction reaction, Cu 13 shows barely any activity toward only 2e product CO with a maximum 13% FE at −1.1 V. In contrast, Cu 14 can promote CO 2 deep reduction to hydrocarbons (CH 4 and C 2 H 4 ) with maximum FE of 54.3% at −1.2 V. Based on the crystallographic and computational analyses, the extra Cu at the top in Cu 14 squeezes the H connected with three core Cu into the center of the same plane, optimizing the electronic structure and thereby promoting CO 2 activation and H 2 O dissociation, which is further confirmed by comprehensive in situ characterizations, kinetic experiments, and theoretical calculations. This work provides a unique isostructural NCs system to gain fundamental insights into switching catalytic reactivity by single-atom manipulation.}, archive = {J_ANGEW}, author = {Chao Han and Tao Yang and Youqiong Fang and Yuanxin Du and Shan Jin and Lin Xiong and Manzhou Zhu}, doi = {10.1002/anie.202503417}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503417}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Steering the product selectivity of CO2 electroreduction by single atom switching in isostructural copper nanocluster catalysts}, volume = {64}, year = {2025}, }
• (2025). Impact of hydrogen vacancies on non-radiative recombination in metal-halide perovskites. ANGEW, 64(19), e202503394. (www)

  @article{ , abstract = {Hydrogen vacancies (V H ) were considered major non-radiative recombination centers in hybrid perovskites. By employing a multiscale approach that combines first-principles calculations and molecular dynamics (MDs) simulations, our findings indicated that the V H impact was overestimated due to the previous metastable V H configurations. The organic molecules with V H located on either the nitrogen or carbon atom act as the ligands that form energetically stable dimers with Pb 2+ cations. These dimers lower V H energy by 0.35–0.97 eV in MAPbI 3 and by 0.88–1.01 eV in FAPbI 3 , compared to non-bonding configurations. These dimers significantly boosted potential energy barriers of hole capture, resulting in a dramatic reduction in carrier capture coefficients by over 10 orders of magnitude. Consequently, the total capture coefficients ( C total ) for the dominant V H in MAPbI 3 and FAPbI 3 are on the order of 10 −17 and 10 −31 cm −3 s −1 , respectively. By uncovering the negligible impact of V H on non-radiative recombination, this work shifts the focus toward more significant defects, for instance, iodine interstitial (with a capture coefficient on the order of 10 −8 cm −3 s −1 ), thereby paving the way for optimizing perovskite solar cells efficiency to meet the Shockley–Queisser limit.}, archive = {J_ANGEW}, author = {Wencai Zhou and Xiqi Yang and Rongkun Zhou and He Huang and Yongcai He and Xiaoqing Chen and Cheng Qian and Zilong Zheng and Hui Yan}, doi = {10.1002/anie.202503394}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503394}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Impact of hydrogen vacancies on non-radiative recombination in metal-halide perovskites}, volume = {64}, year = {2025}, }
• (2025). Blocking orbital π-conjugation to boost spin-orbit coupling in carbonyl-embedded polycyclic heteroaromatic emitters. ANGEW, 64(19), e202503371. (www)

  @article{ , abstract = {Both reducing singlet-triplet energy gaps (Δ E S1T1 ) and enhancing spin-orbit couplings (SOCs) are key to improving reverse intersystem crossing rates ( k RISC ) in thermally activated delayed fluorescence (TADF) materials. While considerable efforts have focused on reducing Δ E S1T1 , investigations on SOCs remain limited. Here, blocking π-conjugation in carbonyl-embedded polycyclic heteroaromatic (PHA) molecules as potential approach to elevate ππ* excitation energy, allowing its hybridization with nπ* excitation, thereby increasing SOCs is proposed. Two proof-of-concept isomers, DNDK-1 and DNDK-2 are synthesized, with different orientations of carbonyl units. DNDK-1 adopts a heavily twisted structure that hinders π-conjugation, while DNDK-2 remains quasi-planar, maintaining stronger π-conjugation. Experimental measurements reveals stark differences in their photophysical properties, with DNDK-1 exhibiting faster k RISC and much higher electroluminescence efficiency. The ab-initio calculations elucidate that hindered conjugation in DNDK-1 elevates ππ* excitation energy, enabling nπ*-ππ* mixing, thus significantly boosting SOCs. In contrast, smooth π-conjugation in DNDK-2 leads to marginal nπ*-ππ* mixing. In addition, utilizing groups composed of meta-arranged carbonyl-Ar-carbonyl and meta-arranged N-Ar-N units emerges as another approach to block π-conjugation and enhance SOCs. This joint experimental and theoretical work provides promising pathways to enhance SOCs by blocking π-conjugation, offering crucial insights for designing carbonyl-embedded PHA emitters with larger SOCs.}, archive = {J_ANGEW}, author = {Rajat Walia and Xiaochun Fan and Le Mei and Weixiong Guo and Kai Wang and Chihaya Adachi and Xian-Kai Chen and Xiao-Hong Zhang}, doi = {10.1002/anie.202503371}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503371}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Blocking orbital π-conjugation to boost spin-orbit coupling in carbonyl-embedded polycyclic heteroaromatic emitters}, volume = {64}, year = {2025}, }
• (2025). Pd ensemble sites tuned local environment of cu catalysts for matching propyne semi-hydrogenation. ANGEW, 64(19), e202503263. (www)

  @article{ , abstract = {Tailoring local environments of active sites to match targeted configuration of key species is significant for controlling reaction pathways in selective hydrogenations. Herein, differently typed Pd sites are introduced onto Cu catalysts to tune the local environment of Cu sites for controlling the configuration of semi-hydrogenation pathway of propyne hydrogenation used in production of polymer-grade propylene. Detailed structure characterizations demonstrate the controllable construction of Pd single-atom and Pd ensemble sites modified Cu surfaces and PdCu alloy via fine tuning the Pd/Cu ratios. Catalytic tests, kinetics analysis, and temperature-programmed experiments demonstrate that the presence of Pd ensemble sites on Cu surface directly catalyzes the hydrogenation of propyne that occurs on the Cu sites in other cases, and enables a facile activation for hydrogen and simultaneously promotes the desorption of propylene against its hydrogenation. Accordingly, the selectivity to target propylene is up to 95.3% at the full conversion of propyne on the corresponding Pd 0.1 Cu catalyst. In contrast, the C─C coupling pathway is quite facile on the Cu surface tuned by single-atom Pd sites, which is similar to that on the pristine Cu sites on the Cu catalyst, and the well-defined Pd─Cu coordination on PdCu alloy catalyst leads to facile over-hydrogenation process.}, archive = {J_ANGEW}, author = {Kelin Yan and Xiaohu Ge and Yueqiang Cao and Qiang Yuwen and Jing Zhang and Sheng Dai and Gang Qian and De Chen and Xinggui Zhou and Weikang Yuan and Xuezhi Duan}, doi = {10.1002/anie.202503263}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503263}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pd ensemble sites tuned local environment of cu catalysts for matching propyne semi-hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Selectively deoxygenative deuteration of aldehydes by superwetting porous carbon-supported palladium catalysts. ANGEW, 64(19), e202503204. (www)

  @article{ , abstract = {We present a method of deoxygenative deuteration of aldehydes (DDA) over heterogeneously superwetting porous carbon-supported palladium catalyst (Pd/SPC), which is efficient for the synthesis of deuterated aromatic compounds with -CD 3 group. Exemplified by the DDA reaction of 2-naphthaldehyde (2-NAL) to 2-methylnaphthalene (2-MNE), the total deuterium incorporation radio in the resultant aromatic hydrocarbons was higher than 95% and the selectivity toward 2-MNE- d 3 reached 87%. The impressed catalytic activity was found relevant to the combined effect of surface wettability and the electron-rich properties of Pd species of this kind of heterogeneous Pd/SPC catalyst. Mechanistic studies suggest a successive deuteration pathway, that is, hydrogen isotope exchange (HIE), deuterium addition, and ultimate deoxygenative deuteration over Pd/SPC in the cost-effective D 2 O/H 2 reaction conditions. The in situ-formed D 2 from the first step HIE between H 2 and D 2 O can be readily captured by the electron-rich Pd centers, which then boost the subsequent deuterogenolysis of C─O bonds through deuterated alcohol intermediates toward the formation of 2-MNE- d 3 . This work provides a design principle of heterogeneous catalysts for targeted deuterium labeling from aldehyde substrates and may inspire the development of alternative deuterium labeling techniques beyond dominated homogeneous catalysis.}, archive = {J_ANGEW}, author = {Yu-Tai Wu and Feng-Cheng Yang and Guang-Ping Hao and An-Hui Lu}, doi = {10.1002/anie.202503204}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503204}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selectively deoxygenative deuteration of aldehydes by superwetting porous carbon-supported palladium catalysts}, volume = {64}, year = {2025}, }
• (2025). Circularly polarized ultraviolet light-activated asymmetric photopolymerization for the synthesis of CPL-active materials. ANGEW, 64(19), e202503197. (www)

  @article{ , abstract = {Circularly polarized ultraviolet light (CP-UVL) offers significant potential for practical applications in asymmetric photocatalysis and photopolymerization. However, the development of CP-UVL-active materials has been hindered by their low emission dissymmetry factors ( g em ). Here, we present a high-performance CP-UVL material for asymmetric photopolymerization, achieved through thermodynamic regulation of a chiral supramolecular assembly. The chiral coassembled enantiomers, R / S -BNC/OXD-7 , are synthesized using the naphthylamine derivative R / S -BNC as the chiral donor and OXD-7 as the achiral acceptor. Upon annealing at different temperatures, OXD-7 detaches from the chiral coassembly of S -BNC/OXD-7 and then self-assembles into ordered helical nanostructures, exhibiting temperature-dependent CP-UVL ( λ em = 360 nm, with g em up to +0.188). Remarkably, the strong CP-UVL emission acts as a chiral excitation source, triggering the asymmetric photopolymerization of RM257 (which contains the achiral dye TPABBI and the photoinitiator Irg651 ), resulting in the generation of blue CPL ( λ em = 460 nm, g em = −0.072). This study provides a simple yet effective strategy for designing high-performance CP-UVL materials for CPL-induced asymmetric photopolymerization.}, archive = {J_ANGEW}, author = {Qihuan Li and Suwen Zheng and Wentong Gao and Guo Zou and Yixiang Cheng}, doi = {10.1002/anie.202503197}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503197}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Circularly polarized ultraviolet light-activated asymmetric photopolymerization for the synthesis of CPL-active materials}, volume = {64}, year = {2025}, }
• (2025). Unveil the failure of alkali ion-sulfur aqueous batteries: Resolving water migration by coordination regulation. ANGEW, 64(19), e202503138. (www)

  @article{ , abstract = {Sulfur aqueous battery (SAB) is promising owing to its high theoretical capacity and cost competitiveness. Although decoupled electrolyte design has successfully endowed transition metal ion-SABs with customizability to achieve high energy density, its effectiveness in alkali ion-SABs remains problematic. Here, we identify for the first time an intractable phenomenon of alkali-ion-driven water migration between decoupled electrolytes through ex situ NMR, which is recognized as the origin of the irreversible sulfur redox reactions. To address the challenge, we propose an alkali-ion-H 2 O-poor coordination strategy to effectively regulate water migration by incorporating low molecular polarity index (MPI) anions. In situ Raman, synchrotron spectroscopy, and molecule dynamic simulations reveal that the repulsion of low MPI anions to water effectively disrupts the hydration patterns around the alkali cations, and thereby minimizes the concomitant water migration. The elaborated Na + -SAB achieved an ultrahigh capacity of 1634 mAh g −1 (97.7% sulfur utilization) and prolonged stability over 500 cycles. Furthermore, the versatility of the alkali-ion-H 2 O-poor coordination strategy is further substantiated in Li + -SAB and K + -SAB batteries, boosting the scope of the following SAB systems.}, archive = {J_ANGEW}, author = {Xiaoyu Yu and Yutong Feng and Jiazhuang Tian and Xin Liu and Boya Wang and Yanyan Zhang and Tengsheng Zhang and Gaoyang Li and Xinran Li and Hongrun Jin and Wanhai Zhou and Wei Li and Zhiyuan Zeng and Laiquan Li and Dongyuan Zhao and Dongliang Chao}, doi = {10.1002/anie.202503138}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503138}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveil the failure of alkali ion-sulfur aqueous batteries: Resolving water migration by coordination regulation}, volume = {64}, year = {2025}, }
• (2025). Balancing hydrogen evolution and hydrogenation reaction via facet engineering for efficient conversion of nitrate to ammonia in actual wastewater. ANGEW, 64(19), e202503117. (www)

  @article{ , abstract = {Due to the competitive relationship between nitrate reduction reaction (NO 3 − RR) and hydrogen evolution reaction (HER), the conventional approach to improve Faradaic efficiency is to select a catalyst without HER activity. Nevertheless, such a strategy not only limits the application of HER catalysts in NO 3 − RR, but also causes insufficient hydrogen source, thereby sacrificing ammonia yield rate. We believe that HER catalysts should not be excluded from hydrogenation reduction. Herein, taking traditional water electrolysis material Co 3 O 4 as model system, we reveal that the oxygen vacancies on crystal facet can greatly promote water dissociation and capture HER intermediate for NO 3 − RR, successfully shifting the reaction pathway from hydrogen evolution to nitrate hydrogenation. Beyond material development, we construct a hybrid reactor and achieve an ammonia recovery rate of 1216.8 g-N m −2 d −1 in nuclear industry wastewater with ultra-high nitrate concentration. This study breaks through the limitation of HER catalyst in NO 3 − RR, which provides a significant insight into the catalyst designing and hydrogenation mechanism.}, archive = {J_ANGEW}, author = {Wenye Zhong and Yan Chen and Peiyan Chen and Qiaowen Chen and Chunzhen Yang and Nian Zhang and Xueming Liu and Zhang Lin}, doi = {10.1002/anie.202503117}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503117}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Balancing hydrogen evolution and hydrogenation reaction via facet engineering for efficient conversion of nitrate to ammonia in actual wastewater}, volume = {64}, year = {2025}, }
• (2025). Temperature-dependent mechanistic control of nonadiabatic tunnelling in triplet carbenes. ANGEW, 64(19), e202503066. (www)

  @article{ , abstract = {Experiments on three chemically similar triplet carbenes observed the reaction of one at 10 K, another only when heated to 65 K, whereas the third remained stable despite heating. As the products are singlets, it is clear that the reactions involve intersystem crossing in addition to intramolecular hydrogen transfer. Here, instanton theory is used to study various possible reaction mechanisms, including sequential and concerted pathways. The latter describes a new reaction mechanism which involves changing spin state (a nonadiabatic process) while heavy atoms tunnel underneath a barrier (an adiabatic process). In each case, we find that the concerted pathway dominates the rate at low temperatures, but at higher temperatures it switches to a sequential mechanism. The existence of a crossover temperature is the key to explaining the experimental observations and demonstrates that temperature can control the reactivity of triplet carbenes via nonadiabatic tunnelling.}, archive = {J_ANGEW}, author = {Meghna A. Manae and Jeremy O. Richardson}, doi = {10.1002/anie.202503066}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503066}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Temperature-dependent mechanistic control of nonadiabatic tunnelling in triplet carbenes}, volume = {64}, year = {2025}, }
• (2025). All-alkynyl protected rod-shaped Au9(AgCu)126 nanocluster with remarkable photothermal conversion. ANGEW, 64(19), e202503036. (www)

  @article{ , abstract = {High-nuclearity intermetallic nanoclusters are important for investigating the evolution of alloy materials from atoms to plasmonic alloy nanoparticles. However, the synthesis of large-size alloy nanoclusters (∼2 nm) is still challenging. In this work, an all-alkynyl protected trimetallic nanocluster of unprecedented size, Au 9 Ag 126- x Cu x (PhCC) 68 (BF 4 ) 5 ( x = 0–20) ( 1 ) (PhCC = phenylacetylene), has been synthesized and its total structure determined by single crystal X-ray diffraction (SCXRD). The metal core of 1 is rod-like in structure, with a length of 1.92 nm and a width of 1.45 nm. Cluster 1 contains a concentric metal kernel in the manner of shell-by-shell arrangements of Au 3 Ag 34 @Au 6 Ag 64 @(AgCu) 28 protected by 68 PhCC ligands with 15 distinct alkynyl–metal binding configurations. Theoretic calculation reveals that 1 features a HOMO–LUMO energy gap of 0.29 eV. This suggests that 1 is situated at the boundary of the transition from a molecular to a metallic state. Remarkably, compared to other reported Au/Ag/Cu/Pd based nanoclusters, 1 exhibits significantly enhanced photothermal conversion capability. A substantial temperature rise of ∼51.5 °C within 5 min ( λ ex = 660 nm, 0.5 W cm −2 ) and a record high photothermal conversion efficiency of 84.7% at 12 µM in N,N -dimethylformamide (DMF) were observed. Time-resolved transient absorption (TA) spectroscopy reveals that the electron–phonon coupling (τ e-ph ) of excited 1 occurs on the femtosecond timescale, resulting in an ultrafast electronic relaxation process and excellent photothermal performance. Cluster 1 , when employed as a photothermal material, shows promise in biothermal therapy, photothermal catalysis, and photothermal imaging.}, archive = {J_ANGEW}, author = {Nian-Ling Li and Jianyu Wei and Xiao-Yun Ran and Jing Li and Li Shen and Fawang Zhang and Qi Dai and Wei Wang and Kun Li and Xian-Kai Wan}, doi = {10.1002/anie.202503036}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503036}, shortjournal = {Angew. Chem. Int. Edit.}, title = {All-alkynyl protected rod-shaped Au9(AgCu)126 nanocluster with remarkable photothermal conversion}, volume = {64}, year = {2025}, }
• (2025). Highly selective electrocatalytic 1,4-NADH regeneration based on Host–Guest recognition mediated by cucurbit[8]uril on NiO. ANGEW, 64(19), e202503018. (www)

  @article{ , abstract = {Efficient regeneration of nicotinamide adenine dinucleotide (NADH) cofactors, particularly 1,4-NADH, is crucial for advancing oxidoreductase catalysis. Electrocatalysis provides a promising route for 1,4-NADH regeneration, but an expensive catalyst, typically a rhodium organometallic complex, is frequently required to guarantee the high selectivity of 1,4-NADH, significantly limiting its large-scale application. Herein, inspired by the catalytic pocket and enzyme–substrate interaction in nature, a direct electrochemical 1,4-NADH regeneration route was designed by modification of the surface of nickel oxide (NiO) with cucurbit[8]uril (CB[8]) (denoted as CB[8]–NiO). The host–guest interaction between CB[8] and NAD + was proved, which is similar in principle to substrate–enzyme-specific recognition. CB[8] acted as a catalytic pocket for NAD + , providing a suitable cavity volume to accommodate the positively charged nicotinamide part of NAD + . NAD + entered the CB[8] cavity and approached the surface-adsorbed hydrogen atoms on NiO in a reaction-ready configuration to achieve the regioselective 1,4-NADH regeneration. Remarkably higher 1,4-NADH selectivity of 97.8% on CB[8]–NiO was obtained at −0.47 V versus reversible hydrogen electrode (RHE) than that of bare NiO (77.4%).}, archive = {J_ANGEW}, author = {Hongxia Ning and Yizhou Wu and Chang Liu and Ziqi Zhao and Zeju Li and Jian Dai and Peili Zhang and Fei Li and Licheng Sun and Fusheng Li}, doi = {10.1002/anie.202503018}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202503018}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly selective electrocatalytic 1,4-NADH regeneration based on Host–Guest recognition mediated by cucurbit[8]uril on NiO}, volume = {64}, year = {2025}, }
• (2025). Unusual 1,1-dicarboxylation selectivity in the domino hydrocarboxylation of alkynes with formate and application in polyimide photoresists. ANGEW, 64(19), e202502920. (www)

  @article{ , abstract = {We report for the first time a photoinduced domino 1,1-dicarboxylation of alkynes for the synthesis of malonic acid derivatives using a cesium formate solution (80% w/w in water), which is different from previous 1,2-dicarboxylation methods that usually produce succinic acids. Cesium malonate precipitated directly from the diluted reaction mixture and was collected by filtration without further purification. Interestingly, solid cesium formate with additional water led to a mono-carboxylation product. The solubility of cesium formate and alkaline environment are two key factors contributing to the outcome. A series of malonic acids, propionic acids and drug intermediates were synthesized by the methods in good yields. Mechanism experiments and DFT calculations indicate that the malonic acid is formed through the α-selective addition of CO 2 •− to a cinnamate intermediate. This method enables direct preparation of water-soluble carboxylate-functionalized molecules and polymers from hydrophobic alkyne-containing precursors, showing potential usability in photolithography for semiconductor manufacturing.}, archive = {J_ANGEW}, author = {Yaxin Sun and Peng Yang and Jianbiao Liu and Pin Liu and Xu Wang and Jianrong Steve Zhou and Bo Tang}, doi = {10.1002/anie.202502920}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502920}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unusual 1,1-dicarboxylation selectivity in the domino hydrocarboxylation of alkynes with formate and application in polyimide photoresists}, volume = {64}, year = {2025}, }
• (2025). Sub-minute fabrication of metal organic framework membranes via additive-accelerated electrodeposition. ANGEW, 64(19), e202502862. (www)

  @article{ , abstract = {Efficient fabrication of metal organic framework (MOF) membranes is important for their broad applications in molecular separations. However, current approaches for MOF membrane fabrication are usually time-consuming due to the slow, random nucleation and crystal growth, particularly the lack of in-situ defect healing ability. Here, we report an additive-accelerated electrodeposition method, which allows ultrafast fabrication of MOF membranes through the synergy of electric field and catecholamine additives. The strong electric field facilitates the directed nucleation of MOF on the substrates while the multifunctional additives accelerate the MOF crystallization, growth and grain-boundary defect healing. Consequently, we fabricate well-intergrown, uniform MOF (ZIF-8) membranes with an ultrathin thickness of ∼180 nm in 30 s, which is the most rapid fabrication of MOF membranes till now. The membranes exhibit superior C 3 H 6 /C 3 H 8 separation performance with a C 3 H 6 permeance of 145 GPU and a C 3 H 6 /C 3 H 8 separation factor of 151, as well as good stability at high pressure of 7 bar, and the ultrafast membrane fabrication can be achieved on commercial ceramic substrates, exhibiting the potential for practical applications. This work may establish a platform for fast and controllable fabrication of MOF membranes as well as many other membranes based on metal-coordination chemistry.}, archive = {J_ANGEW}, author = {Jianyu Wang and Yanxiong Ren and Yifan Wang and Zhenyang Li and Ziheng Song and Quan Zhao and Mingang Zhao and Heyang Liu and Hanze Ma and Jinyue Wang and Yuao Dong and Yanshuo Li and Guangwei He and Zhongyi Jiang}, doi = {10.1002/anie.202502862}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502862}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sub-minute fabrication of metal organic framework membranes via additive-accelerated electrodeposition}, volume = {64}, year = {2025}, }
• (2025). Synthesis of glycolipid library reminiscent of mycobacterial cell wall motif a and its significance by microscopy. ANGEW, 64(19), e202502837. (www)

  @article{ , abstract = {The cell wall of Mycobacterium tuberculosis (MTb) is distinguished by its unique glycolipid composition, notably mycolyl arabinogalactan, which features Ara f , Gal f , and mycolic acid. The terminal portion of arabinogalactan (AG) is motif A, a pentaarabinofuranoside characterized by two β -1,2 linkages and one each of α -1,5 and α -1,3 linkages. The C5 positions of motif A are esterified with mycolic acids, further enriched by unusual cyclopropanes. In this study, we synthesized a diverse array of MTb cell wall glycolipids inspired by motif A and explored their self-assembly behavior using microscopy. This collection of glycolipids includes variations with α or β -(1→2, 3, or 5) Ara f linkages in di-, tri-, tetra-, and penta-arabinofuranosides, esterified with saturated, doubly unsaturated, or cyclopropanated long-chain fatty acids. The TEM analysis of the resulting self-assemblies revealed that subtle modifications in the anomeric linkages, length of the glycan, and the presence or absence of cyclopropanes impacted the morphology of the self-assembled structures.}, archive = {J_ANGEW}, author = {Pooja Joshi and V. Srinidhi and Srinivas Hotha}, doi = {10.1002/anie.202502837}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502837}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of glycolipid library reminiscent of mycobacterial cell wall motif a and its significance by microscopy}, volume = {64}, year = {2025}, }
• (2025). Leveraging solvent effects for enhanced oxidation and coordination in selective piezocatalytic gold recovery from end-of-life electronics. ANGEW, 64(19), e202502751. (www)

  @article{ , abstract = {Efficient gold (Au) recovery from electronic waste (E-waste) under environmentally sustainable and mild conditions presents a significant challenge in resource recycling. This study introduced a novel piezocatalytic method for Au recovery from E-waste using a mixed acetonitrile–water (CH 3 CN-H 2 O) solution. The findings emphasize the crucial role of solvent effects in modulating catalytic performance, with a 75% CH 3 CN solution offering the most efficient recovery. The solvent not only influenced the oxidation and coordination steps crucial for Au extraction but also facilitated electron and mass transfer, accelerating the generation of reactive species that promote Au dissolution. Furthermore, water amplified the effect of the solvent by modifying the chemical potential of surface species, thus optimizing catalytic reactivity. Under ultrasonic vibration, the piezocatalytic system achieved 100% Au recovery from various types of E-waste, exhibiting excellent adaptability across a broad pH range. Large-scale experiments at the kilogram level confirmed its practicality, with 100% recovery from printed circuit boards and 98% from central processing unit boards. This study underscores the importance of solvent effects in piezocatalysis and provides new insights into the sustainable recovery of precious metals, thereby paving the way for the design of solvent-assisted catalytic systems.}, archive = {J_ANGEW}, author = {Daixi Zhou and Zhi Li and Yao Chen and Haojie Dong and Yuanyi Zhou and Zhenfeng Bian and Mingshan Zhu}, doi = {10.1002/anie.202502751}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502751}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging solvent effects for enhanced oxidation and coordination in selective piezocatalytic gold recovery from end-of-life electronics}, volume = {64}, year = {2025}, }
• (2025). Repurposing post-consumer polyethylene to access cross-linked polyethylene with reprocessability, recyclability, and tunable properties. ANGEW, 64(19), e202502641. (www)

  @article{ , abstract = {Polyethylene (PE) is the most widely produced plastic but accumulation and resistance to degradation has significantly contributed to the plastic waste crisis. Upcycling has presented promising solutions to transform PE waste into value-added products. In this study, mixed post-consumer PE was successfully repurposed into reprocessable and chemically recyclable cross-linked polyethylene (XLPE). This process involved converting PE into telechelic oligomers, followed by repolymerization using a hybrid cross-linking system consisting of a dynamic cross-linker 2,4,6-triethoxy-1,3,5-triazine (TETA) and non-dynamic cross-linker tris(6-isocyanatohexyl)isocyanurate (Tri-HDI). In the resulting XLPE, TETA facilitated iterative reprocessing with minimal property degradation across cycles, whereas Tri-HDI helped preserve functional performance throughout service life. Compared to PE, XLPE exhibited enhanced mechanical properties, reduced creep deformation under application-relevant temperatures, and high temperature structural stability. Notably, copolymerizing PE oligomers with commercial macrodiols was employed to create composite XLPEs, enabling tuning material properties. After use, XLPE can be efficiently and selectively depolymerized under mild conditions, even when mixed with commercial insulator cables. This depolymerization allows for the recovery of the constituent building blocks, enabling purification and subsequent repolymerization for reuse. This approach demonstrates the potential of repurposing plastic waste into sustainable materials and fostering the development of a circular economy.}, archive = {J_ANGEW}, author = {Kun Liu and Yucheng Zhao and Anna M. Wolff and Katherine L. Harry and Emma M. Rettner and Joel Miscall and Nicholas A. Rorrer and Garret M. Miyake}, doi = {10.1002/anie.202502641}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Repurposing post-consumer polyethylene to access cross-linked polyethylene with reprocessability, recyclability, and tunable properties}, volume = {64}, year = {2025}, }
• (2025). Gem-diboronic acids: A motif for anion recognition in competitive media. ANGEW, 64(19), e202502582. (www)

  @article{ , abstract = {Gem -diboronic acid derivatives have previously been demonstrated to facilitate substrate binding within a metal's secondary coordination sphere, but their use as an anion recognition motif has not been explored. Here, we introduce the gem -diboronic acid motif as a highly effective group for recognition of oxoanions in aqueous solution. Anion receptors based on this motif demonstrate higher binding affinities than other common neutral motifs such as amides and (thio)ureas, and display a unique selectivity profile. Studies with a receptor bearing two gem -diboronic acid groups, receptor 2, indicate that the interaction with anions is highly directional. Despite its simplicity, receptor 2 represents one of the most selective receptors for malonate reported to date.}, archive = {J_ANGEW}, author = {Stephen M. Butler and Daniel M. Beagan and William Lewis and Nathaniel K. Szymczak and Katrina A. Jolliffe}, doi = {10.1002/anie.202502582}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502582}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gem-diboronic acids: A motif for anion recognition in competitive media}, volume = {64}, year = {2025}, }
• (2025). Additive-free ethylene dimerization over well-defined nickel-zeolite catalysts. ANGEW, 64(19), e202502563. (www)

  @article{ , abstract = {Ethylene dimerization is a crucial chemical process, which currently relies on organo-metallic catalysis with the assistance of overdosed additives as cocatalysts. Heterogeneous nickel catalysts have been investigated as alternatives for ethylene dimerization, however suffer from low catalytic activity and/or poor 1-butene selectivity. Herein, we report a simple two-step ion-exchange strategy for the preparation of Ni-Mg-Y zeolite containing well-defined coordinatively-unsaturated nickel centers as a promising catalyst for ethylene dimerization. Ni-Mg-Y shows unprecedent performance with 1-butene formation rate of 3.8 × 10 5 h −1 and 1-butene selectivity of 91.2 %, without the assistance of any cocatalysts. With the combination of advanced characterization techniques and comprehensive theoretical simulations, it has been demonstrated for the first time that the in-situ generated Ni-alkyl motif is the intrinsic active site and ethylene dimerization proceeds dominantly via the Cossee-Arlman pathway. The dynamic hydrogen transfer between ethylene/alkyl ligand and zeolite framework dedicates to the observed catalytic performance.}, archive = {J_ANGEW}, author = {Li Wang and Jun Ke and Yuchao Chai and Guangjun Wu and Chuanming Wang and Landong Li}, doi = {10.1002/anie.202502563}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502563}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Additive-free ethylene dimerization over well-defined nickel-zeolite catalysts}, volume = {64}, year = {2025}, }
• (2025). Improving circularity via chemical recycling to all rings. ANGEW, 64(19), e202502436. (www)

  @article{ , abstract = {Aliphatic polyesters synthesized via ring-opening polymerization (ROP) have properties competitive to incumbent plastic (PE, PP), while simultaneously opening up for chemical recycling to monomer (CRM). However, not all aliphatic polyesters are prone to undergo CRM, and the ability to shift the equilibrium between polymer and monomer is tightly associated with the initial monomer structure. The standard strategy to measure CRM is to evaluate the change in free energy during polymerization (∆G ROP ). However, ∆G ROP is only one-dimensional by assessing the equilibrium between initial monomer and polymer. But under active catalytic conditions, the depolymerization of polymers can lead to formation of larger rings, such as dimers, trimers, tetramers, and so on, via the ring-chain equilibrium (RCE), meaning that the real thermodynamic recycling landscape is multi-dimensional. This work introduces a multi-dimensional chemical recycling to all rings (CRR) via a highly active catalytic system to reach RCE. Thermodynamically ∆G RCE is completely different from ∆G ROP . Using ∆G RCE instead of ∆G ROP allows us to achieve CRR for polymers notoriously difficult to achieve CRM for, as exemplified within by CRR for poly(ε-caprolactone), poly(pentadecalactone), and mixed polymer systems. Overall, this work provides a new general concept of closing the material loop.}, archive = {J_ANGEW}, author = {Vincent Nieboer and Karin Odelius and Peter Olsén}, doi = {10.1002/anie.202502436}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502436}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving circularity via chemical recycling to all rings}, volume = {64}, year = {2025}, }
• (2025). Redox-mediated CO2 electrolysis for recovering transmembrane carbon loss. ANGEW, 64(19), e202502420. (www)

  @article{ , abstract = {CO 2 electrolysis in alkaline media presents advantages by suppressing the competitive hydrogen evolution reaction (HER) and enhancing the CO 2 reduction selectivity. However, it suffers from the carbonation issue, leading to substantial carbon loss due to CO 2 transmembrane transport. To tackle this issue, we here put forward a redox mediator (RM)-coupled electrolysis strategy. By integrating a highly reversible redox couple, this approach spatially separates the cathodic CO 2 reduction and the anodic oxygen evolution reactions (OERs) into two electrolyzers, thereby enabling the recovery and reuse of transmembrane CO 2 . Anthraquinone-2,7-disulfonic acid (AQDS) was chosen as the redox mediator owing to its suitable redox potential, excellent electrochemical reversibility, high solubility, and nontransmembrane shuttling characteristics. It allowed the RM-coupled electrolysis system to operate continuously at 100 mA/cm 2 , maintaining a high Faradaic efficiency (FE) for CO 2 -to-CO conversion consistently around 90%, while effectively capturing the transmembrane CO 2 . This proof-of-concept demonstration validates the feasibility of RM-coupled electrolysis and highlights its significant potential to advance the practical application of CO 2 electrolysis.}, archive = {J_ANGEW}, author = {Xinhui Yu and Liwei Xue and Yiheng Liao and Li Xiao and Gongwei Wang and Lin Zhuang}, doi = {10.1002/anie.202502420}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502420}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-mediated CO2 electrolysis for recovering transmembrane carbon loss}, volume = {64}, year = {2025}, }
• (2025). Sustainability-inspired upcycling of organophosphorus pollutants into phosphatic fertilizer in a continuous-flow reactor. ANGEW, 64(19), e202502408. (www)

  @article{ , abstract = {With the increasing requirement for phosphorus resources and their shortage in nature, cyclic utilization of organophosphorus pollutants into phosphatic fertilizer might offer a sustainable approach to achieve the recycling of phosphorus. Herein, we first report the selective degradation of organophosphorus pollutants, via the synergistic effect of peroxymonosulfate (PMS) and sodium percarbonate (SPC), into phosphates ( o -PO 4 3− ), which are continually converted into phosphatic fertilizer by struvite precipitation on the continuous-flow reactor. Quenching experiments, electron paramagnetic resonance (EPR) results, electrochemical analysis, and density functional theory (DFT) calculation suggest that the transfer of electrons from SPC to PMS results in the synthesis of catalytically active species (i.e., ·OH, ·O 2 − , 1 O 2 , and CO 3 · − ) for hydroxyethylidene-1,1-diphosphonicacid (HEDP) degradation. For the real glyphosate wastewater, the PMS/SPC system exhibits excellent catalytic activity with 69.20% decrease in chemical oxygen demand (COD) and 37.80% decrease in the total organic carbon (TOC) after 90 min. Indeed, high performance liquid chromatography (HPLC) confirms that glyphosate is completely degraded in 90 min with the formation of 271.93 µmol/L of o -PO 4 3− , which is further converted into phosphatic fertilizer by the precipitation of struvite with 87.20% yield on continuous-flow reactor. Finally, biotoxicity of glyphosate to zebrafish and wheat seeds are significantly deceased after treatment of PMS/SPC system by zebrafish toxicology assays and germination tests of wheat seeds.}, archive = {J_ANGEW}, author = {Zhangli Li and Di Huang and Yazhou Wang and Jiaying Yan and Yue Liu and Haiyu Zhao and Xianyong Lan and Yingping Huang and Didier Astruc and Xiang Liu}, doi = {10.1002/anie.202502408}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502408}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sustainability-inspired upcycling of organophosphorus pollutants into phosphatic fertilizer in a continuous-flow reactor}, volume = {64}, year = {2025}, }
• (2025). Retarding phase segregation via lattice reinforcement for efficient and stable Perovskite/Organic tandems. ANGEW, 64(19), e202502391. (www)

  @article{ , abstract = {The operational perovskite/organic tandems are subjected to light irradiation and driven by a higher bias voltage than single-junction solar cells, posing a severe challenge to their stabilities. Light irradiation can trigger halide phase segregation in the perovskite subcell, exacerbated under higher bias voltage through electron–phonon coupling. To address this, dimethylammonium ion (DMA + ) incorporation delays perovskite crystallization by forming an intermediate phase, enhancing crystallinity, and reducing lattice structural defects. DMA + with a larger ionic radius entering the A-site of lattice tilts the [PbX 6 ] 4− (X: I or Br) octahedral, enlarging the perovskite bandgap, shortening Pb─I bonds, and reinforcing the lattice. This mitigates halide escaping from the lattice and subsequent ion migration. Phase segregation in the perovskite subcell is significantly suppressed under high-power irradiation and bias voltage. Consequently, the perovskite subcell exhibits increased and stable quasi-Fermi-level splitting values, delivering a high open-circuit voltage of 1.34 V. Notably, 0.062-cm 2 and 1.004-cm 2 perovskite/organic tandems achieved remarkable efficiencies of 26.15% (certified of 25.34%) and 24.87%, respectively, exhibiting excellent operational stability of T 90 ∼ 1350 h.}, archive = {J_ANGEW}, author = {Pengpeng Dong and Zhichao Zhang and Weijie Chen and Jialei Zheng and Jiacheng Xu and Ziyue Wang and Shuaiqing Kang and Haiyang Chen and Xingxing Jiang and Jianlei Cao and Yaowen Li and Yongfang Li}, doi = {10.1002/anie.202502391}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Retarding phase segregation via lattice reinforcement for efficient and stable Perovskite/Organic tandems}, volume = {64}, year = {2025}, }
• (2025). Engineering asymmetric electronic structure of Co─N─C single-atomic sites toward excellent electrochemical H2O2 production and biomass upgrading. ANGEW, 64(19), e202502383. (www)

  @article{ , abstract = {To advance electrochemical H 2 O 2 production and unravel catalytic mechanisms, the precise structural coordination of single-atomic M-N-C electrocatalysts is urgently required. Herein, the Co─N 5 site with an asymmetric electronic configuration is constructed to boost the two-electron oxygen reduction reaction (2e − ORR) compared to symmetric Co─N 4 , effectively overcoming the trade-off between activity and selectivity in H 2 O 2 production. Both experimental and theoretical analyses demonstrate that breaking the symmetry of Co─N sites promotes the activation of O 2 molecules and moderates the adsorption of the key *OOH intermediate by disrupting the linear scaling relationship for intermediates adsorption. This modulation enables efficient H₂O₂ production and its effective retention for subsequent applications. As a proof of concept, Co─N 5 achieves a H 2 O 2 production rate as high as 16.1 mol g cat −1 h −1 in a flow cell, outperforming most recently reported counterparts. Furthermore, the coupling of 2e − ORR with the oxidation of cellulose-derived carbohydrates accomplishes high formic acid yields (84.1% from glucose and 62.0%–92.1% from other substrates), underpinning the sustainable electro-refinery for biomass valorization at ambient conditions. By elucidating the intrinsic relationship between 2e⁻ ORR and the asymmetry of single-atomic sites, this work paves the way for high-performance electrosynthesis.}, archive = {J_ANGEW}, author = {Kun Yu and Shiming Guan and Wenbiao Zhang and Wanling Zhang and Yuying Meng and Huaijun Lin and Qingsheng Gao}, doi = {10.1002/anie.202502383}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering asymmetric electronic structure of Co─N─C single-atomic sites toward excellent electrochemical H2O2 production and biomass upgrading}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of inherently chiral Pillar[5]Arenes through copper-catalyzed Azide–Alkyne cycloaddition. ANGEW, 64(19), e202502381. (www)

  @article{ , abstract = {Pillar[n]arenes have been extensively investigated as carrier materials for applications in host-guest chemistry, nanoscience, information science, materials science, and other domains. Despite its success, the enantioselective synthesis of pillar[n]arenes is challenging and has not yet been achieved. Herein, a novel asymmetric extended side-arm strategy is presented for synthesizing chiral pillar[5]arenes through an iterative copper-catalyzed azide–alkyne cycloaddition reaction. An increase in the steric hindrance on both sides of the macrocyclic molecule efficiently produced a wide range of pillar[5]arenes in high yields with excellent enantioselectivities. Moreover, this principle enables iterative copper-catalyzed azide–alkyne cycloaddition to enantioselectively functionalized pillar[5]arenes with different triazoles using a one-pot process.}, archive = {J_ANGEW}, author = {Wen-Guang Zhou and Long-Long Xi and Mei-Ru Zhang and Hao-Ran Wang and Mei An and Jia-Hao Li and Ren-Rong Liu}, doi = {10.1002/anie.202502381}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502381}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of inherently chiral Pillar[5]Arenes through copper-catalyzed Azide–Alkyne cycloaddition}, volume = {64}, year = {2025}, }
• (2025). Concentrated chloride electrolytes enable high-efficiency, long-cycling, and dendrite-free aqueous trivalent antimony batteries. ANGEW, 64(19), e202502279. (www)

  @article{ , abstract = {Aqueous trivalent metal batteries are promising energy storage systems, which can leverage unique three-electron redox reactions to deliver high capacity and high energy. Among them, antimony (Sb) stands out with a high capacity (660 mAh g −1 ), abundant availability, and low cost. However, the severe Sb 3+ hydrolysis reaction drastically hinders the development of aqueous antimony batteries. Herein, we address this issue by employing a concentrated lithium chloride electrolyte, which stabilizes reactive Sb 3+ ions via forming robust antimony-chloride complexes. This approach effectively mitigates hydrolysis and achieves highly reversible Sb plating behavior, leading to high efficiency (99.7%–99.8%), long lifespan (7300 h, 10 months), and uniform spherical deposition morphology. When paired with a manganese dioxide (MnO 2 ) cathode, the Sb‖MnO 2 battery demonstrates a high capacity of 309 mAh g −1 and exceptional cycling stability of 50 000 cycles (∼70% retention). Additionally, Sb shows promise as a high-capacity cathode, which can integrate with low-potential zinc into novel dual-metal plating batteries with long cycling life (4,000 h). This work not only deepens our fundamental understanding of trivalent Sb 3+ redox chemistry but also opens new opportunities to stabilize hydrolysable and high-charge-density cations for multivalent battery applications.}, archive = {J_ANGEW}, author = {Irfan Ullah and Songyang Chang and Wentao Hou and Angelica Del Valle-Perez and Xiaoyu Du and Swati Katiyar and Dalice M. Piñero Cruz and Lisandro Cunci and Gerardo Morell and Xianyong Wu}, doi = {10.1002/anie.202502279}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502279}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concentrated chloride electrolytes enable high-efficiency, long-cycling, and dendrite-free aqueous trivalent antimony batteries}, volume = {64}, year = {2025}, }
• (2025). A promising deep ultraviolet nonlinear optical crystal activated by the ordered structure design. ANGEW, 64(19), e202502252. (www)

  @article{ , abstract = {Deep-ultraviolet nonlinear optical (DUV NLO) crystals play a vitally important role in many scientific and technological fields, yet their rational design remains an ongoing challenge. Here, through utilizing the ordered structure design, a new KBe 2 BO 3 F 2 -like DUV transparent NLO crystal Cs 2 KY(B 3 O 6 ) 2 has been successfully designed and synthesized, in which we first use the largest π -conjugated B 3 O 6 functional groups to substitute the BO 3 to maximize the second-harmonic generation (SHG) response and utilize the K/YO 6 connecting groups to replace two BeO 3 F groups to optimize the layer connections. Eventually, Cs 2 KY(B 3 O 6 ) 2 exhibits not only the largest SHG responses in KBe 2 BO 3 F 2 -like DUV borates but also the best growth rate along c axis (the strong layer-habit along c axis has been being the greatest obstacle to prohibit the practical application of KBe 2 BO 3 F 2 and its derivative). Clearly, the substitution from BO 3 triangles to similar topological B 3 O 6 groups and from (BeO 3 F) 2 groups to similar topological K/YO 6 octahedra can better modulate the functional properties of materials in the larger scale. That results in the superior comprehensive properties of Cs 2 KY(B 3 O 6 ) 2 and makes it a promising DUV NLO crystal. Therefore, the ordered structure design provides some new insights for assembling the functional and connecting groups to rationally design materials with high-performance.}, archive = {J_ANGEW}, author = {Haonan Liu and Xuming Zhai and Xinru Li and Hongping Wu and Zhanggui Hu and Jiyang Wang and Yicheng Wu and Hongwei Yu}, doi = {10.1002/anie.202502252}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A promising deep ultraviolet nonlinear optical crystal activated by the ordered structure design}, volume = {64}, year = {2025}, }
• (2025). Anomalous magnetic hysteresis up to 20 k in a non-kramers light-lanthanide single-molecule magnet. ANGEW, 64(19), e202502228. (www)

  @article{ , abstract = {Light-lanthanides (Ln), despite their widespread uses in commercial permanent magnets, are among the least explored metal elements as building blocks of single-molecule magnets (SMMs) due to their smaller magnetic moments as well as weaker spin–orbit couplings than those of the heavy-Ln counterparts, and so far, only a neodymium (Nd) complex has been reported showing a small magnetic hysteresis at 2 K. Here, we report a low-coordination praseodymium (Pr) complex, namely, Pr@C 81 N, featuring a non-Kramers trivalent Pr ion entrapped within an azafullerene cage and behaving as the first Pr-based SMM. Although the weak nonaxial ligand field imposed only by the carbon cage on the integer-spin Pr(III) elicits nondegenerate spin states, Pr@C 81 N shows an anomalous magnetic hysteresis up to 20 K using a field sweep rate of 20 Oe/s, which is the highest temperature among all reported light-Ln SMMs. In addition to the ideally minimized spin–phonon coupling in the low coordination, the origin of such an unexpected magnetic bistability for the non-Kramers complex likely lies in nuclear sublevels arising from a large Pr hyperfine coupling, which feature distinct electronic magnetizations within the highly mixed ground electronic state.}, archive = {J_ANGEW}, author = {Xinyi Han and Zhanxin Jiang and Ziqi Hu and Yang-Rong Yao and Aman Ullah and Alejandro Gaita-Ariño and Wensheng Yan and Yalin Lu and Shangfeng Yang}, doi = {10.1002/anie.202502228}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502228}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anomalous magnetic hysteresis up to 20 k in a non-kramers light-lanthanide single-molecule magnet}, volume = {64}, year = {2025}, }
• (2025). A triphenylamine-functionalized co-assembly material for record efficiency inverted CsPbI3 perovskite solar cells. ANGEW, 64(19), e202502221. (www)

  @article{ , abstract = {The precise regulation of self-assembled monolayer (SAM) distribution and interfacial modification is pivotal for advancing the performance of p-i-n inverted perovskite solar cells (PSCs). Here, a new co-assembly material, 4-(aminomethyl)- N , N -diphenylaniline iodide (TPAI), is developed to make SAM orderly assembled. Density functional theory (DFT) calculation and sum frequency generation (SFG) spectroscopy reveal that TPAI binds with SAM via π-π interactions, effectively suppressing SAM aggregation and enhancing the orderliness of self-assembly. Further characterization by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) demonstrates that ─NH 3 group in TPAI coordinates with undercoordinated Pb 2+ to passivate defects of cesium lead triiodide (CsPbI 3 ) film. The TPAI modification creates a defect-minimized buried interface with optimized energy alignment, significantly improving hole extraction and transport kinetics. Consequently, the TPAI-treated CsPbI 3 PSCs achieve a high power conversion efficiency (PCE) of 21.60%, the highest reported value for inverted CsPbI 3 PSCs, maintaining 96.71% initial PCE after tracking at maximum power point (MPP) for 1400 h. This work provides a molecular-level strategy for interfacial engineering, advancing the development of efficient and durable perovskite photovoltaics.}, archive = {J_ANGEW}, author = {Dongfang Xu and Huaiman Cao and Zihao Fan and Baihui Wang and Yongzhe Li and Rui Sun and Yong Li and Jieke Tan and Hongjie Lei and Yuwei Duan and Hongtao Bian and Ze Yu and Zhike Liu}, doi = {10.1002/anie.202502221}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A triphenylamine-functionalized co-assembly material for record efficiency inverted CsPbI3 perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Electronegative strategic positions in covalent organic frameworks: Unlocking high-efficiency gold recovery. ANGEW, 64(19), e202502199. (www)

  @article{ , abstract = {Gold (Au) concentrations accumulated from electronic waste (e-waste) and industrial leachates far surpass those found in natural ores, a highly valuable resource if efficient recovery methods can be developed. Despite advancements in covalent organic frameworks (COFs), achieving adsorbents with high selectivity, large capacity, and rapid adsorption kinetics remain challenging because of limitations in partial pore wall sites. Here, we present hexaazatriphenylene-based COFs (HATP-COFs) with an electronegative skeleton, specifically designed for selective Au recovery. The hexaazatriphenylene centers, imine linkages, and pyridine linkers within the COFs introduce electron-rich sites that extend across strategic positions—vertex, linkages, and linkers—thereby enhancing the overall structural integrity. These features facilitate efficient Au capture through electrostatic interactions, achieving an exceptional adsorption capacity exceeding 2366 mg g −1 with rapid kinetics, making HATP-COFs one of the most efficient pure COFs reported to date. Moreover, these HATP-COFs demonstrate remarkable selectivity, stability, and scalability. Theoretical calculations reveal that the electronegative skeleton introduces critical binding sites, promoting strong electrostatic interactions with Au 3+ ions and improving adsorption kinetics. This work highlights the potential of charge-interface engineering in COFs as a transformative strategy for developing next-generation materials.}, archive = {J_ANGEW}, author = {Zhongping Li and Wanyi Zhao and Changqing Li and Yawei Yin and Dongxue Wei and Yucheng Jin and Yongfeng Zhi and Jikuan Qiu and Yuwei Zhang and Jong-Beom Baek}, doi = {10.1002/anie.202502199}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502199}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronegative strategic positions in covalent organic frameworks: Unlocking high-efficiency gold recovery}, volume = {64}, year = {2025}, }
• (2025). Synergistic catalysts for lithium-sulfur batteries: Ni single atom and MoC nanoclusters composites. ANGEW, 64(19), e202502177. (www)

  @article{ , abstract = {The practical application of sulfur (S) cathodes in lithium-sulfur (Li-S) batteries is hindered by the shuttling of soluble lithium polysulfides (LiPSs) and sluggish sulfur redox kinetics. Addressing these challenges requires advanced catalytic host materials capable of trapping LiPSs and accelerating Li-S redox reactions. However, single-site catalysts struggle to effectively mediate the complex multi-step and multi-phase sulfur conversion processes. In this study, we present a novel dual-site catalyst, Ni-MoC-NC, featuring nickel single atoms anchored to nitrogen sites (Ni-N 4 ) within a carbon nitride (NC) matrix and molybdenum carbide (MoC) nanoclusters. Experimental and theoretical analyses reveal that MoC sites efficiently catalyze the reduction of long-chain LiPSs (Li₂S₈ to Li₂S₄), while Ni-N 4 sites drive the reduction of short-chain LiPSs (Li₂S₄ to Li₂S), resulting in a synergistic enhancement of the complete Li-S redox process. When incorporated as a coating on the cathode side of a commercial polypropylene (PP) separator, the Ni-MoC-NC catalyst enhances sulfur utilization, suppresses LiPSs shuttling, and facilitates a uniform Li + -ion distribution, effectively mitigating the uncontrolled growth of lithium dendrites. Thereby, Li-S batteries employing an S/Ni-MoC-NC cathode and a Ni-MoC-NC@PP separator demonstrate outstanding performance, including an initial capacity of 1624 mAh g⁻¹ at 0.2C and 1142 mAh g⁻¹ at 1C, retaining 590 mAh g⁻¹ after 800 cycles. At a sulfur loading of 8.3 mg cm⁻ 2 and an electrolyte/sulfur ratio of 6 µL mg⁻¹, the system achieves an initial areal capacity of 9.57 mAh cm⁻ 2 at 0.1C, showcasing significant promise for practical applications.}, archive = {J_ANGEW}, author = {Chongchong Zhao and Yanxia Liu and Feng Huo and Zhenzhen Guo and Yurui Lu and Bowen Sun and Meng Li and Hui Xu and Min Zhang and Hailin Fan and Zixu Sun and Andreu Cabot and Yatao Zhang}, doi = {10.1002/anie.202502177}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502177}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic catalysts for lithium-sulfur batteries: Ni single atom and MoC nanoclusters composites}, volume = {64}, year = {2025}, }
• (2025). Electrochemical pilot H2O2 production by solid-state electrolyte reactor: Insights from a hybrid catalyst for 2-electron oxygen reduction reaction. ANGEW, 64(19), e202502144. (www)

  @article{ , abstract = {The electrochemical oxygen reduction reaction (ORR) offers an alluring and sustainable alternative to the traditional anthraquinone process for hydrogen peroxide (H₂O₂) synthesis. However, challenges remain in developing scalable electrocatalysts and cost-effective reactors for high-purity H₂O₂ production. This study introduces a simple yet effective mechanical mixing method to fabricate a hybrid electrocatalyst from oxidized carbon nanotubes and layered double hydroxides (LDHs). This easily accessible and low-cost catalyst achieves near-perfect Faradaic efficiency (∼100%) with low overpotentials of 73 mV at 10 mA cm⁻ 2 and 588 mV at 400 mA cm⁻ 2 in a solid electrolyte cell. Through theoretical calculations and in-situ analyses, we uncover the pivotal role played by the LDH co-catalyst in fine-tuning the local pH at the catalyst/solid-electrolyte interface that drives both the activity and selectivity. We also design a low-cost solid-state reactor using cation-exchange resin (CER) as both a proton conductor and a microchannel for efficient mass transfer, achieving a production rate of 5.29 mmol cm⁻ 2 h⁻¹ and continuous output concentrations of 11.8 wt.% H₂O₂. Scaled to an industrial area of 2 × 100 cm 2 , the pilot reactor achieves an impressive H₂O₂ production rate of approximately 127.0 mmol h⁻¹ at 15 A, marking a significant advancement in sustainable H₂O₂ production.}, archive = {J_ANGEW}, author = {Shengjian Lin and Jun Wang and Junxiang Chen and Peng Lin and Huibing Wang and Junheng Huang and Zhenhai Wen}, doi = {10.1002/anie.202502144}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical pilot H2O2 production by solid-state electrolyte reactor: Insights from a hybrid catalyst for 2-electron oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Unravelling the oxygen evolution mechanism of lithium-rich antifluorite prelithiation agent based on anionic oxidation. ANGEW, 64(19), e202502126. (www)

  @article{ , abstract = {Developing sacrificial cathode prelithiation technology to compensate for irreversible lithium loss is crucial for enhancing the energy density of lithium-ion batteries. Antifluorite Li-rich Li 5 FeO 4 (LFO) is a promising prelithiation agent due to its high theoretical capacity (867 mAh g −1 ) and superior decomposition dynamic (<4.0 V vs. Li/Li + ). However, the oxygen evolution mechanism in LFO remains unclear, limiting its application as an ideal prelithiation agent. Herein, we systematically track the full lifecycle oxygen footprint in LFO lattice, electrolyte and solid electrolyte interface (SEI). We demonstrate the lattice mismatch induced by the quasi-disorder rocksalt intermediate phase can activate the lattice oxygen oxidation promoting the dimerization to O 2 . Specifically, in contrast to the O─O dimers formed within typical anionic-redox active cathodes, the oxidation of lattice oxygen in LFO generates O − stabilized in Li 6 -O configuration. Significantly, a pair of edge-sharing Li 6 -O configurations transforms into a superoxo dimer, which further evolves into O 2 via a ligand-to-metal charge transfer process. Moreover, we demonstrate that nucleophilic intermediates threaten the stability of electrolytes and SEI. Leveraging the insights above, we offer comprehensive perspectives for the modification of ideal prelithiation agents.}, archive = {J_ANGEW}, author = {Yuanlong Zhu and Ruoyu Xu and Yichun Zheng and Yilong Chen and Jianhua Yin and Jiyuan Xue and Baodan Zhang and Li Li and Guifan Zeng and Haiyan Luo and Xiaohong Wu and Kang Zhang and Zixin Wu and Siyu Yang and Shuoyu Li and Yang Sun and Datong Zhang and Yu Qiao and Shi-Gang Sun}, doi = {10.1002/anie.202502126}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502126}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unravelling the oxygen evolution mechanism of lithium-rich antifluorite prelithiation agent based on anionic oxidation}, volume = {64}, year = {2025}, }
• (2025). Homochiral helical poly(thiophene)s accessed via living catalyst-transfer polymerization. ANGEW, 64(19), e202502104. (www)

  @article{ , abstract = {Synthetic helical polymers form compact, ordered, and inherently chiral structures, enabling their uses in biomimetic applications as well as catalysis. A challenge in using synthetic helical polymers, however, is their tendency to be sensitive to pH and the presence of nucleophiles, Lewis-acids, or metal ions. We report a strategy to overcome these shortcomings by adapting catalyst-transfer polymerization, a living chain-growth polymerization typically used to access linear conjugated polymers, for the synthesis of helical poly(thiophene)s. We demonstrate that the helical poly(thiophene)s can be synthesized with a single helicity, incorporated into block copolymers, and functionalized at the chain-ends, enabling further conjugation and functionalization. The helical poly(thiophene)s are stable to a variety of conditions, providing benefits over other helical polymers which contain sensitive imine or carbonyl-based functional groups. We anticipate that the ability to access homochiral, heterotelechelic helical conjugated polymers and copolymers will enable new uses of these materials in optoelectronics as well as in applications for mimicking biomacromolecules and other polymers with precisely defined sequences.}, archive = {J_ANGEW}, author = {Matthew D. Hannigan and Jada A. Sampson and Lasya Damaraju and Marcus Weck}, doi = {10.1002/anie.202502104}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Homochiral helical poly(thiophene)s accessed via living catalyst-transfer polymerization}, volume = {64}, year = {2025}, }
• (2025). Single-grain high-efficiency full-visible-spectrum white emitters. ANGEW, 64(19), e202502100. (www)

  @article{ , abstract = {Full-visible-spectrum emission phosphors are promising candidates for next-generation white light-emitting diodes (WLEDs), overcoming the complex and high costs of traditional mixed phosphors. However, their practical application is hindered by low luminescence efficiency. In this regard, a generalization strategy is developed that involves creating heterostructure interfaces to prevent detrimental energy transfer processes, thereby boosting efficiency. The SrLiPO 4 /Sr 9 MgLi(PO 4 ) 7 :Eu 2+ single-grain phosphors prepared in this work have achieved remarkable full-visible-spectrum emission efficiency, with record internal and external quantum efficiencies of 76.1% and 56.2%, respectively. The WLEDs encapsulated with this phosphor feature a high color rendering index (≈93.9), a low correlated color temperature (≈3100 K), and stable color performance, indicating that the as-synthesized single-grain phosphors are excellent candidates for healthy full-visible-spectrum lighting. This innovation is expected to accelerate the development of full-visible-spectrum phosphors technology and inspires the creation of more efficient and versatile luminescent materials in the future.}, archive = {J_ANGEW}, author = {Shuifu Liu and Xianfeng Yang and Rongkai Du and Shidan Rao and Taizhong Xiao and Lei Zhou and Jean-Claude G. Bünzli and Mingmei Wu}, doi = {10.1002/anie.202502100}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502100}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-grain high-efficiency full-visible-spectrum white emitters}, volume = {64}, year = {2025}, }
• (2025). A compact-solvation electrolyte under low concentration for high-energy density and stable potassium-ion batteries. ANGEW, 64(19), e202502016. (www)

  @article{ , abstract = {The development of potassium-ion batteries (PIBs) faces significant challenges due to the lack of suitable electrolytes to achieve satisfactory energy density and long-term stability. This work reports an innovative compact-solvation electrolyte (CSE) strategy leveraging ionic liquid-induced manipulation of solvation structures under low concentration for high-performance PIBs. The CSE, formulated with a low-salt concentration of 0.8 M, simultaneously exhibits compact solvation structures with abundant F-rich anions, high-ionic conductivity, and low-desolvation energy. These features lead to enhanced K-storage thermodynamics and kinetics through the formation of a robust KF-rich solid electrolyte interphase (SEI) as well as accelerated K + transport kinetics. Consequently, the graphite electrode in CSE delivers a high-reversible capacity of 252 mAh g −1 with an average Coulombic efficiency of 99.5% after 300 cycles at 50 mA g. Furthermore, the designed CSE enables the Prussian blue||graphite full cell to operate for over 1450 cycles at 50 mA g −1 , maintaining an impressive capacity retention of 88%. This work represents a significant advance in the development of safe and compatible electrolytes for advanced PIBs.}, archive = {J_ANGEW}, author = {Jing Zheng and Xiaokang Chu and Hao Wang and Ran Chen and Haobo Xia and Long Chen and Yuxiao Lin and Yunsong Li and Zixia Lin and Mengtao Ma and Qingxue Lai and Xiulin Fan}, doi = {10.1002/anie.202502016}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202502016}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A compact-solvation electrolyte under low concentration for high-energy density and stable potassium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Biphenylene coordination and ring-opening by alkali-metal nickelates. ANGEW, 64(19), e202501995. (www)

  @article{ , abstract = {The pre-coordination of substrates to heterobimetallic complexes plays a key role in facilitating challenging bond activations and catalytic reactions. Herein, we report a family of low-valent phenyl-alkali-metal nickelates containing a η 4 -coordinated biphenylene ligand and demonstrate how the coordination and solvation preferences of the alkali-metal cation (Li, Na, or K) influence the rate of C─C bond oxidative addition at nickel through combined structural, spectroscopic and computational studies. The rate of C─C bond cleavage can be further manipulated by replacing the two phenyl-carbanionic ligands with a cyclic 2,2′-biphenyl scaffold, which affords thermally stable and symmetric spirocyclic nickelates upon ring-opening.}, archive = {J_ANGEW}, author = {Andryj. M. Borys and Aurore E. F. Denjean and Luca Vedani and David Balcells and Eva Hevia}, doi = {10.1002/anie.202501995}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501995}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biphenylene coordination and ring-opening by alkali-metal nickelates}, volume = {64}, year = {2025}, }
• (2025). Short-path hydrogen spillover on CeO2-supported PtPd nanoclusters for efficient hydrogen evolution in acidic media. ANGEW, 64(19), e202501964. (www)

  @article{ , abstract = {Hydrogen spillover in supported metal electrocatalysts has garnered significant research attention for its potential to enhance the hydrogen evolution reaction (HER) efficiency. However, challenges remain in facilitating hydrogen spillover and reducing the associated energy barriers. Herein, PtPd alloy clusters are anchored to the CeO 2 surface, enabling short-path hydrogen spillover and lowering the reaction energy barrier in acidic environments. During HER, hydrogen is initially adsorbed on the noble metal surface and subsequently migrates to the interface, rather than precipitating directly on the CeO 2 surface. This interface exhibits a near-zero Gibbs free energy of hydrogen adsorption (0.023 eV). Consequently, the catalyst demonstrates an exceptionally low overpotential of only 5.7 mV at 10 mA cm −2 in acidic media, along with remarkable long-term stability. These findings provide valuable insights into designing highly efficient HER electrocatalysts for acidic environments based on hydrogen spillover mechanisms.}, archive = {J_ANGEW}, author = {Zixin Yan and Zirui Liu and Guosheng Zhou and Tianchen Jin and Huanhuan Zhang and Lin Gu and Tong Gao and Shijie Shen and Wenwu Zhong}, doi = {10.1002/anie.202501964}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501964}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Short-path hydrogen spillover on CeO2-supported PtPd nanoclusters for efficient hydrogen evolution in acidic media}, volume = {64}, year = {2025}, }
• (2025). Chiral bimetallic Pt@Au octapods with spiral four-petal flower-like symmetric configuration as sensitive SERS probes. ANGEW, 64(19), e202501894. (www)

  @article{ , abstract = {Here, we synthesized chiral bimetallic Pt@Au octapods by using l / d -cysteine–threonine (CT) dipeptide as chiral ligands. These had a distinct spiral four-petal flower-like symmetric configuration with a twisted concave morphology on each facet. The twisted concave structure of the Pt@Au octapods facilitated intraparticle coupling, resulting in highly concentrated electric fields within the concave regions, thus creating “hot spots” that produced a potent surface-enhanced Raman scattering (SERS) effect. The l -Pt@Au octapods showed a nearly twofold stronger SERS response to Aβ40 and Aβ42 monomers and fibrils than the d -Pt@Au octapods. The different association constants arose from the unique chiral recognition capabilities of the CT ligands on the surfaces of the l -Pt@Au octapods, which allowed them to form specific hydrogen bonds with Aβ40 and Aβ42 monomers and fibrils, producing significant differences in their Raman spectra. The data from clinical cerebrospinal fluid (CSF) samples showed that the quantitative analysis of the Aβ42/Aβ40 ratio with Raman spectroscopy can be used as an effective biomarker for the early diagnosis of Alzheimer's disease (AD), with a cut-off value of 0.085. Our results pave the way for the use of chiral nanomaterials with strong optical activities in the development of clinical testing instruments with biomedical applications.}, archive = {J_ANGEW}, author = {Dexiang Li and Gaoyang Wang and Maozhong Sun and Aihua Qu and Chuanlai Xu and Qing Wang and Changlong Hao and Hua Kuang}, doi = {10.1002/anie.202501894}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501894}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral bimetallic Pt@Au octapods with spiral four-petal flower-like symmetric configuration as sensitive SERS probes}, volume = {64}, year = {2025}, }
• (2025). Fully conjugated benzobisoxazole-bridged covalent organic frameworks for boosting photocatalytic hydrogen evolution. ANGEW, 64(19), e202501869. (www)

  @article{ , abstract = {2D covalent organic frameworks (2D-COFs) have attracted extensive interest in solar energy to hydrogen conversion. However, insufficient light harvesting and difficult exciton dissociation severely limit the improvement of photocatalytic activity for COFs, thereby impeding the progression of this advanced field. In this work, two benzobisoxazole-bridged and fully conjugated 2D-COFs with triazine (COF-JLU44) and pyrene (COF-JLU45) units were constructed for the first time via Knoevenagel polycondensation, and they hold long-range ordered structures, largely acceptable surface area, and fascinating photoelectric properties. Significantly, COF-JLU45 exhibits an impressive hydrogen evolution rate of 272.5 mmol g −1 h −1 and superior reusability in the presence of 1.0 wt% Pt under light irradiation, coupled with a remarkable apparent quantum yield of 12.9% at a long wavelength of 600 nm. Multiple spectroscopy and theoretical simulation demonstrate the ingenious design of COF-JLU45 widen its light absorption and effectively promote the exciton dissociation. This finding contributes valuable insights for constructing metal-free photocatalysts for solar energy conversion and utilization.}, archive = {J_ANGEW}, author = {Si Ma and Zhongping Li and Yuxin Hou and Jiali Li and Zhenwei Zhang and Tianqi Deng and Gang Wu and Rui Wang and Shuo-wang Yang and Xiaoming Liu}, doi = {10.1002/anie.202501869}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fully conjugated benzobisoxazole-bridged covalent organic frameworks for boosting photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Robust p-d orbital coupling in PtCoIn@Pt Core–Shell catalysts for durable proton exchange membrane fuel cells. ANGEW, 64(19), e202501805. (www)

  @article{ , abstract = {Pt-based catalysts are playing increasingly important roles in fuel cells owing to their high catalytic activity. However, harsh electrocatalytic conditions often trigger atomic migration and dissolution in these catalysts, causing rapid performance deterioration. Here, a novel L1 0 -PtCoIn@Pt core–shell catalyst is introduced, where indium (In) is incorporated into a PtCo matrix. This integration promotes p–d orbital coupling, optimizing the electronic structure of Pt and causing additional lattice strain within PtCo. Impressively, L1 0 -PtCoIn@Pt exhibits remarkable activity and durability, with only a 5.1% reduction in mass activity (MA) after 120 000 potential cycles. In H 2 -O 2 fuel cells, this cathode achieves a peak power density of 1.99 W cm −2 and maintains a high MA of 0.73 A mg Pt −1 at 0.9 V. After enduring 60 000 square wave potential cycles, the catalyst maintains its initial MA and sustains the cell voltage at 0.8 A cm −2 , exceeding the U.S. Department of Energy (DOE) 2025 targets. Theoretical studies highlight the enhancements originating from the modulated electronic structures and shifted d-band center of Pt induced by In doping and increased vacancy formation energies in Pt and Co atoms, affirming the catalyst's superior durability.}, archive = {J_ANGEW}, author = {Lei Zhao and Zhaozhao Zhu and Junjie Wang and Jiayu Zuo and Haiyuan Chen and Xueqiang Qi and Xiaobin Niu and Jun Song Chen and Rui Wu and Zidong Wei}, doi = {10.1002/anie.202501805}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501805}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust p-d orbital coupling in PtCoIn@Pt Core–Shell catalysts for durable proton exchange membrane fuel cells}, volume = {64}, year = {2025}, }
• (2025). Valence engineering via polyoxometalate-induced on vanadium centers for efficient aqueous zinc-ion batteries. ANGEW, 64(19), e202501728. (www)

  @article{ , abstract = {Layered vanadium-based compounds have attracted attention as cathode materials for aqueous zinc-ion batteries (AZIBs) because of their low cost, high theoretical specific capacity, and abundant vanadium valence states. However, the slow migration of Zn 2+ ions and their poor cycling stability hinder their practical application in AZIBs. Herein, using a one-pot solvothermal method, the polyoxometalates (POMs) were inserted into the aluminum vanadate interlayer spacing, and a series of novel 3D nanoflower cathode materials (HAVO-MMo 6 - X ) were successfully fabricated. The unique electron-rich structure of the POMs accelerated the migration of Zn 2+ on the cathode to obtain a high specific capacity. Owing to the synergistic pillar effect of POMs and HAVO, the interlayer spacing of HAVO-FeMo 6 -50 increased to approximately 14.33 Å. X-ray absorption fine structure spectroscopy was used to analyze the coordination environments of the cathode materials. A combination of in situ and ex situ characterization techniques demonstrated the storage mechanism of Zn 2+ during the charge/discharge process. Furthermore, the experimental results and DFT calculations indicated that the introduction of POMs had the dual function of improving conductivity and reducing the Zn 2+ migration barrier. Thus, this work provides a new perspective on the synergistic interaction between POMs and metal compounds and offers insights into the design of functionally rich nanomaterials.}, archive = {J_ANGEW}, author = {Yanfei Zhang and Qian Li and Wanchang Feng and Haotian Yue and Shengjie Gao and Yichun Su and Yijian Tang and Jun Wu and Zhan Zhang and Yuan Zhang and Mohsen Shakouri and Hsiao-Chien Chen and Huan Pang}, doi = {10.1002/anie.202501728}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501728}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Valence engineering via polyoxometalate-induced on vanadium centers for efficient aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Elucidating the boundary of intercalation vs sequestration in supramolecular polymers by retrosynthetic design toward the construction of complex supramolecular systems. ANGEW, 64(19), e202501693. (www)

  @article{ , abstract = {Controlled social self-sorting by intercalation can offer distinct properties at the supramolecular level that go beyond the sum of its parts. Likewise, controlling narcissistic self-sorting by sequestration can induce unique system properties. In contrast, the interface between the two cases has hitherto remained underexplored, and clear design rules remain elusive. Herein it is demonstrated that by fine-tuning the molecular similarity of supramolecular synthons, intricate control over concerted supramolecular equilibria can be achieved. By reducing the molecular similarity, a former intercalator can be tuned to become a strong or weak sequestrator. Understanding these roles in binary mixtures allows to rationalize more complex tertiary systems. Consequently, the influence of an uncommon dual sequestration mechanism is revealed. Further, an unprecedented hybrid mechanism between supramolecular intercalation and sequestration can be demonstrated. We are hopeful that the results presented herein will contribute to the development and understanding of concerted processes in complex supramolecular systems.}, archive = {J_ANGEW}, author = {Nils Bäumer and Soichiro Ogi and Shigehiro Yamaguchi}, doi = {10.1002/anie.202501693}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501693}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elucidating the boundary of intercalation vs sequestration in supramolecular polymers by retrosynthetic design toward the construction of complex supramolecular systems}, volume = {64}, year = {2025}, }
• (2025). Tunable light-activated platform for controlled hydrogen sulfide release with tracking. ANGEW, 64(19), e202501685. (www)

  @article{ , abstract = {Hydrogen sulfide (H 2 S) is increasingly recognized for its critical role in various physiological and pathological processes. The development of synthetic donors with controllable release profiles is essential for elucidating H 2 S's complex involvement in cellular signaling, which remains a challenge. Herein, we report a diverse collection of photocaged N-methylation thiocarbamates and thiocarbonates, designed to explore how electronic properties and the leaving efficiency of payloads affect H 2 S release behaviors. These compounds are engineered to release carbonyl sulfide (COS) following the removal of photoprotective group (PPG). The COS could be rapidly converted into H 2 S by carbonic anhydrase, and the entire reaction progression was monitored by changes in fluorescence signals. Furthermore, this H 2 S-releasing platform is suitable for conjugation with active pharmaceutical ingredients, facilitating the creation of H 2 S-releasing hybrid prodrugs. Collectively, this novel class of H 2 S donor not only provides valuable tool for H 2 S-related research but also holds significant potential as therapeutic agent.}, archive = {J_ANGEW}, author = {Fang Yuan and Aoxin Guo and Lu Wang and Lulu Ning and Yuan Guo and Jianjian Zhang}, doi = {10.1002/anie.202501685}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501685}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tunable light-activated platform for controlled hydrogen sulfide release with tracking}, volume = {64}, year = {2025}, }
• (2025). Palladium-catalyzed meta C─H alkoxylation and amidation via polarity reversal of nucleophilic reagents. ANGEW, 64(19), e202501648. (www)

  @article{ , abstract = {Norbornene-mediated remote metaselective C─H functionalization of arenes have been limited to relatively weakly electronegative and “soft” species, such as aryl, alkyl, and alkylamino moieties. Herein, we describe the first example of the use of a nucleophilic reagent, such as an alcohol or amide, to replace the electrophilic reagent during the palladium-catalyzed meta C─H alkoxylation or amidation reaction of an arene. The reaction conditions are mild and highly site-selective, thereby facilitating the direct introduction of natural products or drug molecules containing hydroxyl or amido groups at the meta positions of arenes. In addition, the directing group is rapidly convertible into the corresponding aldehyde, which further enhances the applicability of the reaction. Control experiments and density functional theory (DFT) calculations revealed that alcohol and amide polarity reversal induced by hypervalent iodine reagents and the subsequent formation of a Pd(IV) intermediate via the oxidative addition of the aryl–norbornyl–palladacycle intermediate are crucial for promoting the entire catalytic reaction cycle.}, archive = {J_ANGEW}, author = {Xiao-Ping Gong and Heng Yue and Ning Liang and Yu-Yong Luan and Rui-Qiang Jiao and Xi Chen and Yan-Chong Huang and Tian Ding and Bo-Sheng Zhang and Xue-Yuan Liu and Yong-Min Liang}, doi = {10.1002/anie.202501648}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501648}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Palladium-catalyzed meta C─H alkoxylation and amidation via polarity reversal of nucleophilic reagents}, volume = {64}, year = {2025}, }
• (2025). Rapid, precise, and robust supramolecular polymerization from functional oligomeric-charged poly(3-hexylthiophene) amphiphiles. ANGEW, 64(19), e202501552. (www)

  @article{ , abstract = {Nature inspires the design of artificial systems with remarkable rapidity, precision, and functionality, yet achieving these attributes simultaneously remains a challenge. Living crystallization-driven self-assembly (CDSA) methods have enabled the formation of low-dispersity block copolymer nanofibers with crystalline cores, but these processes typically involve moderate or slow growth kinetics to ensure well-controlled and ordered epitaxial crystallization. Here, we report studies on the living CDSA of oligomeric-charged poly(3-hexylthiophene) amphiphiles, demonstrating an unprecedented combination of rapidity and precision. We show that self-seeding can produce nanofibers with controllable lengths up to ∼700 nm within ∼15 min (including 5 min of disassembly and 10 min of re-growth), while seeded growth can generate nanofibers up to > 2000 nm in length within ∼20–40 min, depending on the unimer-to-seed mass ratios. Notably, this robust supramolecular polymerization can be initiated from the surfaces of two-dimensional nanosheets, resulting in hierarchical hairy structures grafted with dense, uniform micellar brushes.}, archive = {J_ANGEW}, author = {Jiandong Cai and Chen Li and Ian Manners}, doi = {10.1002/anie.202501552}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501552}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid, precise, and robust supramolecular polymerization from functional oligomeric-charged poly(3-hexylthiophene) amphiphiles}, volume = {64}, year = {2025}, }
• (2025). Structure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs. ANGEW, 64(19), e202501488. (www)

  @article{ , abstract = {Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed to tether RNF43/ZNRF3 to target membrane proteins, resulting in the degradation of targets at sub-nanomolar concentrations both in vitro and in vivo. However, currently available RNF43/ZNRF3 binders are genetically encoded and have poor plasticity, which limits the design and promotion of such PROTACs. Here, we exploited the AlphaFold-predicted complex structures of ligand-bound RNF43/ZNRF3 and developed a class of chemically tailored peptide binders for ZNRF3/RNF43. With these peptide binders that can be conveniently prepared by de novo peptide synthesis, we established a new membrane protein degradation platform that allows versatile modular design and targeted degradation of clinically relevant membrane proteins, i.e., PD-L1 and EGFR. This study presents a new subtype within the PROTAC field to develop therapeutic peptides targeting membrane proteins.}, archive = {J_ANGEW}, author = {Jibin Cui and Qingyun Zheng and Yicheng Weng and Xiaoguo Zhai and Zhen Su and Yunxiang Du and Xiaoxiong Wei and Yuanyuan Yu and Qian Qu and Man Pan}, doi = {10.1002/anie.202501488}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs}, volume = {64}, year = {2025}, }
• (2025). Thiazolium-linked crystalline porous covalent organic frameworks for mixed electronic-ionic transport. ANGEW, 64(19), e202501472. (www)

  @article{ , abstract = {Developing efficiently mixed electronic-ionic (MEI) conductive microcosmic pathways within a single functional material is essential yet challenging for electronic devices. Covalent organic frameworks (COFs) feature pre-designed functionalities and uniform pores, making them highly desirable platforms for transporting electrons and ions. However, for MEI conductive COFs, achieving high crystallinity when incorporating high-density ionic groups within the extensively π-electron delocalized skeletons remain a challenge due to intermolecular interactions. Herein, we reported a “pre-polymerization followed by self-ionization” approach to synthesize new thiazolium-linked COFs (MEICOFs, M═Cu, Co, Fe), where the ionic groups synthesized following the connection of building blocks. MEICOFs demonstrated broad ultraviolet-visible-near-infrared absorption bands and narrow bandgaps. As a proof of concept, the mixed electronic and hydroxide ionic conductivity of CuEICOF was determined to be 55.2 and 0.01 S m −1 , respectively. Moreover, MEICOFs film could directly catalyze the oxygen reduction reaction without additional conductive agent and the rotation of the electrode.}, archive = {J_ANGEW}, author = {Zhenjie Mu and Kaixin Li and Yuanyuan Yin and Xiangyang Li and Hong Li and Yongxin Cheng and Xiao Feng and Bo Wang and Zhonghua Xiang}, doi = {10.1002/anie.202501472}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thiazolium-linked crystalline porous covalent organic frameworks for mixed electronic-ionic transport}, volume = {64}, year = {2025}, }
• (2025). Electrochemical amino-oxygenation cyclization via alkene radical Cation/Bisnucleophile engagement to saturated N/O-heterocycles. ANGEW, 64(19), e202501424. (www)

  @article{ , abstract = {Regioselective functionalization of alkenes to create nitrogen- and oxygen-containing heterocycles remains a significant challenge in organic synthesis. Because of their unique electronic and biological properties, these heterocycles are crucial in pharmaceuticals and materials. Herein, we present an electrochemical amino-oxygenation of alkenes using alkene radical cations and bisnucleophiles, enabling the synthesis of saturated N / O -heterocycles in an undivided cell. This method employs readily available amides and alkenes, eliminating the need for additional oxidants or redox catalysts. The in situ generation of alkene radical cations results in high yields with excellent regio- and chemoselectivity. Our approach offers a direct route to six-, seven-, and eight-membered N / O -heterocycles from simple starting materials, broadening access to complex molecules essential for medicinal chemistry and materials science.}, archive = {J_ANGEW}, author = {Shengzhang Liu and Hai Lin and Tianjiao Peng and Zhaoliang Yang and Pingnan Wan and Jiarong Li and Lingyun Yang and Xinglei Dai and Sichao Tu and Xiao Long and Aiwen Lei and Tao Wang and Hong Yi}, doi = {10.1002/anie.202501424}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical amino-oxygenation cyclization via alkene radical Cation/Bisnucleophile engagement to saturated N/O-heterocycles}, volume = {64}, year = {2025}, }
• (2025). Electronic localization enables long-cycling sulfides-based all-solid-state lithium batteries. ANGEW, 64(19), e202501411. (www)

  @article{ , abstract = {Argyrodite-based sulfide electrolytes have received considerable attention in all-solid-state lithium metal batteries owing to their high ionic conductivity and good mechanical property. However, the reactivity between sulfide electrolytes and lithium anode leads to continuous interfacial reactions and dendrites growth, which severely hinders their practical applications. We propose an electron localization strategy by modulating the d–p orbital hybridization within the PS 4 tetrahedral structure of Li 6 PS 5 Cl through homogeneous incorporation of yttrium (Y) and oxygen (O). The introduction of Y strengthens the Madelung energy with sulfur (S) atom and induces the electronic localization of S atom, which suppresses the interaction between lithium metal and S atom of the tetrahedron. The air-stability is also enhanced due to oxygen introduction. Furthermore, the in situ formation of Li 2 O interphase acts as a protective barrier, synergistically mitigating the interfacial reactions between lithium metal and Li 6 PS 5 Cl. The Li symmetric cell with the modulated Li 6 PS 5 Cl electrolyte achieves stable lithium plating/stripping for over 4800 h. The all-solid-state batteries with LiCoO 2 /Li-In electrode display a remarkable long cycle performance with 100% retention after 1300 cycles at 0.5 C. This study presents a distinct strategy that employs the electron localization driven by modulating orbital hybridization to achieve ultrastable interface in sulfide-based all-solid-state lithium batteries.}, archive = {J_ANGEW}, author = {Dewen Wang and Chong Liu and Ruoyu Wang and Tianran Zhang and Butian Chen and Tenghui Wang and Qi Lu and Wen Yin and Xiangfeng Liu}, doi = {10.1002/anie.202501411}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501411}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic localization enables long-cycling sulfides-based all-solid-state lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Disentangling radiative and non-radiative deactivation pathways in CuI -based TADF emitters. ANGEW, 64(19), e202501407. (www)

  @article{ , abstract = {The analysis of thermally activated delayed fluorescence emitters traditionally neglects the temperature dependence of the non-radiative singlet and triplet decay rates, which, for systems with quantum yields significantly departing from unity, unavoidably leads to inaccurate determination of the relevant photophysical parameters. Here we address this issue by performing a detailed photophysical study in three solid-state Cu I complexes with the general formula [Cu(dmp)(PPh 3 )X] (X = Cl, Br, I). Decomposition of the measured temperature-dependent lifetimes τ( T ) into their radiative and non-radiative contributions demonstrates a significant temperature dependence of the non-radiative rates, which leads to large deviations of the singlet-triplet gaps Δ E ST from those determined in the traditional way. Our detailed analysis further confirms that non-radiative parameters follow the energy gap law and that zero field splitting effects, which are unrecognizable in the bare τ( T ) data, are governed by the heavy atom effect. Our analysis is supported by measurements of the decay of the prompt fluorescence which is dominated by k ISC in the studied compounds.}, archive = {J_ANGEW}, author = {Leonel Llanos and Sebastian Staforelli and Allen G. Oliver and Francisco G. Moscoso and Reinhold Wannemacher and Juan Cabanillas-Gonzalez and Luis Lemus and Daniel Aravena}, doi = {10.1002/anie.202501407}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501407}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Disentangling radiative and non-radiative deactivation pathways in CuI -based TADF emitters}, volume = {64}, year = {2025}, }
• (2025). Simultaneous electrochemical upgrading of biomass and CO2 utilization using Fe/Ni-derived carbon nanotubes derived from CO2. ANGEW, 64(19), e202501404. (www)

  @article{ , abstract = {Fossil fuel consumption has caused petroleum shortages and increased carbon emissions; thus, utilizing renewable resources in biorefineries for biomass-derived chemical synthesis is promising. Among them, 2,5-furandicarboxylic acid (FDCA) is a key alternative to terephthalic acid (PTA) for sustainable polyester production. In this work, we demonstrate an efficient approach for the simultaneous production of FDCA while utilizing carbon dioxide (CO₂) via an electrochemical approach. Complete electrooxidation of hydroxymethylfurfural (HMF) at the anode yields FDCA, while CO₂ reduction at the cathode produces valuable compounds such as carbon monoxide (CO). This concurrent HMF electrooxidation and CO₂ electroreduction strategy enables high-value chemical production at mild conditions. In addition, we developed efficient single catalysts, FeNi metals supported on CO₂-derived multi-walled carbon nanotubes deposited on nickel foam (FeNiCNTs/NF) as both the anode and the cathode for HMF oxidation and CO 2 reduction, respectively. Remarkably, faradaic efficiencies reached 99.60% for FDCA (FE FDCA ) at the anode and 96.25% for CO (FE CO ) at the cathode. This study highlights the effective use of synthesized non-noble metals supported on CO₂-derived CNTs for integrated biorefinery and CO₂ utilization.}, archive = {J_ANGEW}, author = {Anousha Sohail and Watinee Nunthakitgoson and Sorasak Klinyod and Anawat Thivasasith and Anittha Prasertsab and Peeranat Chaipornchalerm and Warot Prasanseang and Wanmai Srisuwanno and Poobodin Mano and Somlak Ittisanronnachai and Supawadee Namuangruk and Chularat Wattanakit}, doi = {10.1002/anie.202501404}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501404}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous electrochemical upgrading of biomass and CO2 utilization using Fe/Ni-derived carbon nanotubes derived from CO2}, volume = {64}, year = {2025}, }
• (2025). Spontaneous anionic double Capture/Displacement to trigger single-ion conducting interpenetrating polymer networks with desired ionic conductivity for durable zn metal batteries. ANGEW, 64(19), e202501392. (www)

  @article{ , abstract = {The engineering of single-ion conductors (SICs) is a promising strategy to stabilize the anode/electrolyte interface in zinc-ion batteries. However, the commonly employed single-ion conductive solid or quasi-solid electrolytes often lead to a significant reduction in overall ionic conductivity, thereby impeding ion diffusion kinetics. Here, we propose a compromise strategy that effectively balances ionic conductivity and ion transference number. Specifically, a single-ion conductive interpenetrating polymer networks (IPNs) with phase-functional decoupling is developed solely on the anode side, while a liquid electrolyte is retained on the cathode side. This design facilitates a high ion transference number (0.84) while maintaining the ionic conductivity at an optimal level (12.1 mS cm −1 ). The single-ion-conductive mechanism is unveiled as a spontaneous anionic dual capture/displacement process, which synergizes zincophilic–hydrophobic functionality to ensure efficient reversible Zn 2+ stripping and plating. The modified electrode demonstrates outstanding cycling stability of 1300 h at 5 mA cm −2 . The assembled NH 4 V 4 O 10 //IPNs@Zn full cell exhibits an exceptional lifespan, enduring 9000 cycles with a remarkable retention of 80.8% at 10 A g −1 . This work introduces an effective approach for balancing ionic conductivity and ion transference numbers in SICs, offering a promising pathway for the development of high-performance SICs.}, archive = {J_ANGEW}, author = {Yulong Li and Song Huang and Zuyang Hu and Haoxin Liu and Liang Gao and Xuan Zhou and Minghui Ye and Yufei Zhang and Zhipeng Wen and Yongchao Tang and Xiaoqing Liu and Cheng Chao Li}, doi = {10.1002/anie.202501392}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501392}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spontaneous anionic double Capture/Displacement to trigger single-ion conducting interpenetrating polymer networks with desired ionic conductivity for durable zn metal batteries}, volume = {64}, year = {2025}, }
• (2025). Against the wallach's rule through rational design of metal-free chiral perovskites toward efficient red circularly polarized phosphorescence. ANGEW, 64(19), e202501360. (www)

  @article{ , abstract = {The potential applications of circularly polarized phosphorescent materials in chiroptical devices have attracted considerable interest. Nevertheless, the design of efficient near-infrared/red circularly polarized phosphorescent pure organic materials remains a significant challenge, largely due to the limitations imposed by the energy-gap law and Wallach's rule. In this study, the chiral metal-free perovskite strategy is employed to overcome these restrictions. The introduction of cyclohexylenediammonium cations as the A-site of chiral metal-free perovskites results in the generation of an efficient near-infrared/red phosphorescence at 637 nm with a lifetime of up to 227.98 µs. Furthermore, the photoluminescence quantum yield (PLQY) can reach up to 71.22%, accompanied by an anisotropy factor of 9.8 × 10 −3 . The figure of merit (FM = PLQY× | g lum |) is 6.98 × 10 −3 , which is the highest value achieved among all the pure organic circularly polarized phosphorescent materials. The work proposes a unique strategy to achieve highly efficient near-infrared/red circularly polarized phosphorescence based on non-conjugated luminophores, which is accomplished by combining the superior optical and electronic properties of metal-free perovskites with chirality based on the rational molecular design.}, archive = {J_ANGEW}, author = {Zhaoyu Wang and Haolin Lu and Wenkai Zhao and Hebin Wang and Tengfei He and Tianyin Shao and Xinyi Niu and Tianjiao Qiao and Sehrish Gull and Yunchao Miao and Bing Sun and Hao-Li Zhang and Yongsheng Chen and Guankui Long}, doi = {10.1002/anie.202501360}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501360}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Against the wallach's rule through rational design of metal-free chiral perovskites toward efficient red circularly polarized phosphorescence}, volume = {64}, year = {2025}, }
• (2025). Yb3+-induced bright ligand up-conversion luminescence in 1D coordination polymers. ANGEW, 64(19), e202501349. (www)

  @article{ , abstract = {Ln 3+ -induced ligand up-conversion luminescence (UCL) in coordination polymers (CPs) effectively overcomes the inherent limitations of conventional organic UCL mechanisms. However, current research on UCL in Ln-CPs has predominantly focused on the UCL of Ln 3 ⁺ ions themselves, while investigations into Ln 3 ⁺-induced ligand UCL is overlooked in Ln-CPs. Herein, by doping Yb 3 ⁺ into the Ln-CPs of [Y 2 (FCA) 6 ] n 1 ) (FCA = 9-fluorenone-2-carboxylic acid), Yb 3+ -doped 1D chain Ln-CPs of [Y 2-2x Yb 2x (FCA) 6 ] n (x = 0.2, 2 ) x = 0.5, 3 ) x = 0.7, 4 ) x = 0.9, 5 ) x = 1, 6 ) are prepared. Investigation of the UCL of FCA in these CPs reveals that Ln 3 ⁺-induced ligand UCL are achieved for the first time. Notably, 4 not only displays bright UCL under both 10 and 15 W cm −2 excitation power of 980 nm laser but also achieves an absolute UCQY of 0.003 %, opening new avenues for the development of Ln-CPs as UCL materials.}, archive = {J_ANGEW}, author = {Ming-Xuan Zhang and Tao Jia and Pei-Ming Cheng and Wei-Dong Liu and La-Sheng Long and Lang-Sun Zheng}, doi = {10.1002/anie.202501349}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501349}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Yb3+-induced bright ligand up-conversion luminescence in 1D coordination polymers}, volume = {64}, year = {2025}, }
• (2025). Nonmetallic high-entropy-engineered nanocarbons for advanced ORR electrocatalysis. ANGEW, 64(19), e202501290. (www)

  @article{ , abstract = {High-entropy materials are poised to revolutionize materials science and industrial applications due to their design flexibility, peculiar performance, and broad applicability. In this study, we present a proof-of-concept high-entropy engineered nanocarbon (HENC) co-doped with five nonmetal elements (B, F, P, S, and N), synthesized via in situ polymerization modification of ZIF-8 followed by pyrolysis. The HENC exhibits outstanding performance as a nonmetal electrocatalyst for the oxygen reduction reaction (ORR), with activity on par with benchmark Pt/C electrocatalysts and superior cyclic stability. Simulations and all-site calculations reveal that the synergistic effects of abundant heteroatoms and increased system entropy facilitate the formation of *O 2 species, with N, P, and S acting as the key active elements, while co-doping with B and F further enhances stability. Notably, HENCs have been validated as cathode catalysts in zinc–air batteries, achieving an impressive peak power density of 604 mW cm −2 and demonstrating long-term stability over a 16-day period, outpacing the commercial Pt/C catalyst (542 mW cm −2 ). This work not only enriches the concept of high entropy and advances the understanding of high-entropy materials but also opens a new avenue for the development of high-performance low-cost catalysts.}, archive = {J_ANGEW}, author = {Huibing Wang and Kai Chen and Zhiwen Lu and Shengjian Lin and Yalong Yuan and Xi Liu and Yu Zhang and Junxiang Chen and Zhenhai Wen}, doi = {10.1002/anie.202501290}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501290}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nonmetallic high-entropy-engineered nanocarbons for advanced ORR electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Readily visualized perfluorooctanoic acid detection using a small molecule chemosensor. ANGEW, 64(19), e202501245. (www)

  @article{ , abstract = {Mounting concerns regarding per-/poly-fluoroalkyl substances (PFAS) on human health are focusing attention on trace-level PFAS detection in aqueous environments. Here, we report a readily prepared small molecule, 2,6-bis(3,5-diethyl- 1H -pyrrol-2-yl)pyridine (receptor 1 ), that displays high binding affinities (log K a = 4.9–6.2) and produces a strong “turn-on” emission response when exposed to representative PFAS in hexanes. The hydrophobic nature of 1 , and its strong affinity for various PFAS, allowed hexanes solutions of 1 to be used as “turn-on” emission sensors for dilute aqueous solutions of long-chain (≥C 8 ) PFAS under acidic conditions (pH 2) by liquid-phase extraction (LPE). In the case of perfluorooctanoic acid (PFOA), the response was rapid (under 10 min) and sensitive. Limits of detection (LOD) as low as 250 ppt were readily achievable by direct naked-eye observation. LOD as low as 40 and 100 ppt, respectively, could be reached for deionized and tap water solutions of PFOA using a smartphone color-scanning application. Little change in the sensitivity was seen in the presence of a range of inorganic and organic species that could act as potential interferants. Support for the present findings came from UV–vis absorbance, fluorescence, 1 H/ 19 F NMR spectroscopic analyses, density functional theory calculations, and single-crystal X-ray diffraction analyses.}, archive = {J_ANGEW}, author = {Yu-Dong Yang and Qian Zhang and Xingchen Jin and Calvin V. Chau and Jian Yang and Graeme Henkelman and Xiaodong Chi and Han-Yuan Gong and Richard J. Hooley and Jonathan L. Sessler}, doi = {10.1002/anie.202501245}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501245}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Readily visualized perfluorooctanoic acid detection using a small molecule chemosensor}, volume = {64}, year = {2025}, }
• (2025). Electrocatalytic hydrogenation of olefins. ANGEW, 64(19), e202501215. (www)

  @article{ , abstract = {Electrochemical synthesis offers a powerful and sustainable alternative to conventional chemical manufacturing techniques. The direct and selective electrohydrogenation of olefins has enormous potential applicability; however, this reactivity has not been sufficiently demonstrated. Herein, we show that an efficient Pt-based electrocatalyst from commercially available PtCl 2 can promote such transformations. This approach enables olefins to be electrohydrogenated (often below −3.0 V vs. Ag/AgCl) at high current density ( J Geo up to 133 mA cm −2 ) using protons and electrons as the hydrogen source. This reaction exhibits broad functional group compatibility, requires low catalyst loading, and affords a diverse series of valuable molecules (more than 60 examples) with high chemoselectivity. In addition, highly regioselective electrocatalytic hydrogenation of olefins (r.r. > 19:1) is demonstrated using PtCl 2 and 2,2′-bipyridine.}, archive = {J_ANGEW}, author = {Ping Hu and Wentao Xu and Lang Tian and Hance Zhu and Fabao Li and Xiaotian Qi and Qingquan Lu}, doi = {10.1002/anie.202501215}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501215}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrocatalytic hydrogenation of olefins}, volume = {64}, year = {2025}, }
• (2025). Phosphine→Borane-functionalized pyrenes and anthracenes. ANGEW, 64(19), e202501178. (www)

  @article{ , abstract = {The functionalization of polycyclic aromatic hydrocarbons (PAHs) with N→B Lewis pairs, so-called borylative fusion, has recently emerged as a simple and powerful means to modulate their electronic and photophysical properties thanks to the extension of the π system. Herein, we considered a new class of PAHs appended with phosphine→borane Lewis pairs and investigated pyrene as well as anthracene derivatives. In these compounds, strong P→B interactions are enforced geometrically, but the π-system is not extended. Nevertheless, such P→B functionalization was found to significantly impact the optical and electrochemical properties. The P,B-functionalized PAHs display noticeably reduced HOMO–LUMO gaps and enhanced fluorescence. Both the number and position of P→B units turned out to play a significant role.}, archive = {J_ANGEW}, author = {Arnaud Le Gac and Sonia Mallet-Ladeira and Julien Roger and Jean-Cyrille Hierso and Karinne Miqueu and Ghenwa Bouhadir and Didier Bourissou}, doi = {10.1002/anie.202501178}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501178}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phosphine→Borane-functionalized pyrenes and anthracenes}, volume = {64}, year = {2025}, }
• (2025). Uniform ion flow effect of dynamic electrostatic shielding layer for facilitating homogeneous nucleation and deposition on aluminum anode. ANGEW, 64(19), e202501153. (www)

  @article{ , abstract = {Rechargeable aluminum batteries (RABs) present considerable potential for large-scale energy storage, particularly within power stations. Nonetheless, their operational lifespan and commercialization are hindered by issues like Al anode dendrite formation and electrolyte corrosion. To address the aforementioned issues, a stabilizer has been proposed to enhance the electrolyte/anode interface. Experimental and computational simulation results indicate that the surface tension of the SDBS alkyl chain facilitates its preferential adsorption onto the electrode surface, thereby establishing a protective layer that mitigates the corrosion of the chloroaluminate ionic liquid (ILs). Additionally, the suitable electronegativity of the phenyl-SO 3 group generates an electrostatic shielding effect that not only dynamically regulates ion flow but also equilibrates the nucleation and deposition velocity, ultimately promoting the stable planar Al deposition. Consequently, the SDBS-modified Al//Al symmetric battery demonstrates stable cycling for 500 and 1000 h under high current density (5 mA cm −2 ) and large area capacity (5 mAh cm −2 ), respectively. The Al//flake graphite full battery achieves reversible capacity of 90.01 mAh g −1 after 1000 cycles at 0.5 A g −1 , significantly improving capacity retention. This study also further explores the effect of additive functional groups and ions on Al anodes, offering insights for the rational design of RABs electrolytes.}, archive = {J_ANGEW}, author = {Yuehong Xie and Yifan Liu and Dong Li and Xuan Wang and Danyang He and Panfeng Wang and Lilong Xiong}, doi = {10.1002/anie.202501153}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501153}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Uniform ion flow effect of dynamic electrostatic shielding layer for facilitating homogeneous nucleation and deposition on aluminum anode}, volume = {64}, year = {2025}, }
• (2025). Polychromatic electrochemiluminescence imaging of single heteroligand Metal–Organic crystals. ANGEW, 64(19), e202501151. (www)

  @article{ , abstract = {Conventional polychromatic electrochemiluminescence (ECL) imaging is realized with the several separated luminophores at the different potentials. In this study, an emerging polychromatic ECL imaging system was constructed based on single heteroligand metal–organic framework (MOF) crystals as nanoemitters through an intrareticular energy transfer process. The heteroligand MOF crystals, named h-NJU-241, were coassembled of meso -tetrakis(4-carboxyphenyl)porphyrin (TCPP) with 1,3,6,8-tetrakis( p -benzoic acid)pyrene (TBAPy) ligand using benzoic acid catalyst with coordination ability, leading to the conjugated spacing of 0.624 nm between two ligands. Remarkably, an energy transfer efficiency of 92.2% was achieved when the coordination weight ratio of TCPP acceptor and TBAPy donor was only 1.87‰. Different from monoligand MOFs, the heteroligand h-NJU-241 exhibits dual ECL emissions in both blue and red regions at one step applied potential, which is first example of polychromatic ECL imaging for single MOF crystals. Furthermore, by adjusting the reaction conditions, the morphology distribution of porphyrin within the crystal can be dynamically controlled, providing a tailored crystal platform for decoding fundamentals in polychromatic ECL imaging.}, archive = {J_ANGEW}, author = {Yufei Wang and Tianrui Liu and Siqi Yu and Rengan Luo and Songsong Bao and Jie Wu and Huangxian Ju and Zhihui Dai and Jianping Lei}, doi = {10.1002/anie.202501151}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polychromatic electrochemiluminescence imaging of single heteroligand Metal–Organic crystals}, volume = {64}, year = {2025}, }
• (2025). Arrangement of ordered D–A components in a metal-organic framework for cocatalyst-free photocatalytic hydrogen evolution with efficient proton conduction. ANGEW, 64(19), e202501141. (www)

  @article{ , abstract = {The arrangement of donor–acceptor (D–A) components in order at a molecular level provides a means to achieve efficient electron-hole separation for promoting the activity of photocatalysts. Herein, we report the coordination assembly of D–A molecules with desired staggered energy levels in two isostructural metal-organic frameworks (MOFs) 1 and 2 , which exhibit high photocatalytic hydrogen evolution activity without using any cocatalysts and photosensitizers. The modulation of active metal sites of the D–A MOFs leads to an increase in photocatalytic hydrogen evolution rates from 1260 to 3218 µmol h −1 g −1 . A detailed mechanism study revealed that the energy bond defined by the D–A components assisted with metal centers is the key to efficiently generating photogenerated charge carriers, and 2 has an appropriate affinity to proton to reduce the energy barrier for hydrogen evolution. Besides, the enhanced proton transport kinetics based on the arrayed free carboxyl groups in the hydrogen-bonded network endows 2 with higher proton conductivity than 1 , thus promoting the usage rate of active metal sites in 2 for enhanced hydrogen evolution reaction kinetics.}, archive = {J_ANGEW}, author = {Ning Liu and Jialong Jiang and Shiqi Zhang and Runhao Zhang and Mingming Xu and Zhonghang Chen and Peng Cheng and Wei Shi}, doi = {10.1002/anie.202501141}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Arrangement of ordered D–A components in a metal-organic framework for cocatalyst-free photocatalytic hydrogen evolution with efficient proton conduction}, volume = {64}, year = {2025}, }
• (2025). Precise tuning of functional group spatial distribution on porphyrin rings for enhanced CO2 electroreduction selectivity. ANGEW, 64(19), e202501091. (www)

  @article{ , abstract = {Molecular catalysts play a critical role in regulating the selectivity of electrocatalytic CO 2 reduction reaction (CO 2 RR), yet the understanding of ligand function is largely restricted to modulating the electronic structure of the metal and reaction kinetics. Herein, a hydroxyl (─OH) ligand is introduced into a sterically hindered amino-porphyrin (o-TAPP) to synthesize the atropisomers porphyrin-salicylimine-Cu (o-Cu-Por-Sa) with hydrogen-bonding interactions (O─H⋯O), enabling efficient selection of CO and CH 4 under dual effects. Detailed analysis shows that the ─OH of o-Cu-Por-Sa (αβαβ) forms a noncovalent hydrogen bond with carbonate, characterized by a bond length of 2.01 Å and an angle of 27.6°, and this interaction reduces the reaction energy barrier, achieving a faradaic efficiency (FE) of 84% for CH 4 . Moreover, the steric hindrance effect of the symmetric distribution of ─OH facilitates protonation reactions by preventing C–C coupling. In contrast, ─OH aggregated on o-Cu-Por-Sa (αααα) forms a pocket-like hydrogen bond grid, which restricts free CO 2 adsorption, and the rapid dissociation of *CO also interrupts the reaction. This work highlights the pivotal role of dual effects induced by ligand atropisomerization in regulating selectivity, offering new insights for the design of efficient molecular catalysts.}, archive = {J_ANGEW}, author = {Hao Wang and Chaoqun Ma and Qipeng Lu and Mingzheng Gu and Ling Jiang and Yixin Hao and Feng Hu and Linlin Li and Guangfeng Wang and Shengjie Peng and Xiaojun Zhang}, doi = {10.1002/anie.202501091}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202501091}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise tuning of functional group spatial distribution on porphyrin rings for enhanced CO2 electroreduction selectivity}, volume = {64}, year = {2025}, }
• (2025). Site-selectively accelerating the generation of β-linked residue isoaspartate in proteins. ANGEW, 64(19), e202500983. (www)

  @article{ , abstract = {Isoaspartate (isoAsp) is a β-linked residue in proteins spontaneously generated through Asn deamidation or Asp dehydration and significantly affects protein properties. However, the sluggish and site-nonselective generation of isoAsp residues in proteins severely impedes in-depth biological investigations as well as the exploitation of its unique β-linkage features. Herein, we introduce a method that allows site-selective and rapid generation of isoAsp residues in proteins. This method leverages the genetic incorporation of a side-chain-esterified Asp derivative (BnD), which undergoes facile intramolecular arrangement to form the key intermediate, aspartyl succinimide (Suc); subsequent hydrolysis of Suc gives rise to isoAsp as the major product. On native sites of proteins, including Cu/Zn superoxide dismutase and calmodulin, we demonstrate that BnD-mediated isoAsp formation is faster than Asn deamidation generally by three orders of magnitude.}, archive = {J_ANGEW}, author = {Qifan Wu and Xiaochen Yang and Ying Wang and Hongqiang Qin and Xun-Cheng Su and Weimin Xuan}, doi = {10.1002/anie.202500983}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500983}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-selectively accelerating the generation of β-linked residue isoaspartate in proteins}, volume = {64}, year = {2025}, }
• (2025). Enabling aryl chloride-mediated Palladium/Norbornene cooperative catalysis. ANGEW, 64(19), e202500897. (www)

  @article{ , abstract = {While the palladium/norbornene (Pd/NBE) cooperative catalysis has become increasingly useful for arene functionalization, its substrate scope has been mainly restricted to reactive aryl iodides and bromides. Despite being a more available and attractive feedstock, common aryl chlorides have not been used as substrates for the Pd/NBE catalysis. Herein, we report the first general Pd/NBE-catalyzed vicinal difunctionalization of aryl chlorides. Enabled by the combination of secondary-amide-substituted NBEs and XPhos ligand, diverse aryl chlorides can now undergo successful ortho alkylation, amination, and acylation with different ipso terminations, including olefination, hydrogenation, and alkynylation. To show the utility of this method, late-stage derivatizations of complex bioactive compounds and sequential functionalizations of polyhaloarenes have been achieved.}, archive = {J_ANGEW}, author = {Rong Ye and Xin Liu and Guangbin Dong}, doi = {10.1002/anie.202500897}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500897}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enabling aryl chloride-mediated Palladium/Norbornene cooperative catalysis}, volume = {64}, year = {2025}, }
• (2025). Isomeric 1,4-dihydropentalene-containing building blocks for high mobility ladder-type conjugated polymers. ANGEW, 64(19), e202500860. (www)

  @article{ , abstract = {Nearly amorphous conjugated polymers, though lacking long-range order, can exhibit high charge carrier mobility and enhanced flexibility, making them ideal for flexible or stretchable OFET applications. However, research on novel structural blocks for this class of materials remains limited. We report the synthesis of two derivatives of the 5,10-dihydroindeno[2,1- a ]indene (DHI) core, where two thieno groups are appended to each end to reduce torsional disorder with adjacent comonomers. The two 1,4-dihydropentalene containing isomers, anti-C16DHIT-Br and syn-C16DHIT-Br, feature distinct thieno group orientations, leading to differences in their electronic properties. The anti-isomer shows a fully delocalized conjugation pathway, whereas the syn isomer exhibits cross-conjugation, limiting delocalization along the polymer backbone. These monomers were copolymerized with benzothiadiazole (BT) to form two conjugated polymers, anti-C16DHIT-BT and syn-C16DHIT-BT, both with highly planar backbones, good solubility, and solution processability. Morphological studies reveal that anti-C16DHIT-BT exhibits more ordered stacking and higher crystallinity than syn-C16DHIT-BT. Devices based on anti-C16DHIT-BT show significantly better performance, with a hole mobility of 2.38 cm 2 V −1 s −1 , slightly higher than the widely studied pIDTBT under identical conditions.}, archive = {J_ANGEW}, author = {Shengnan Zhang and Yuqian Liu and Hao Dong and Yanru Li and Kai Zhang and Kaihu Xian and Yang Han and Long Ye and Martin Heeney and Zhuping Fei}, doi = {10.1002/anie.202500860}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500860}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isomeric 1,4-dihydropentalene-containing building blocks for high mobility ladder-type conjugated polymers}, volume = {64}, year = {2025}, }
• (2025). AIE bottlebrush polymers: Verification of internal crowdedness in bottlebrush polymers using the AIE effect. ANGEW, 64(19), e202500850. (www)

  @article{ , abstract = {Bottlebrush polymers, characterized by densely grafted side chains along a central backbone, have gained significant interest due to their unique properties in bulk and solution states. Despite extensive research, a comprehensive understanding of the internal crowdedness within single polymer chains in dilute solutions remains challenging, and direct evidence to visualize and manifest this effect is scarce. Aggregation-induced emission (AIE) offers a novel method to address this challenge. To achieve this, a vinyl-derivatized AIE monomer was polymerized using atom transfer radical polymerization (ATRP) in a controlled way. Afterward, the end group of the synthesized polymer chain was transformed to azide, which was coupled with an alkyne-derivatized norbornene unit using click chemistry to produce the macromonomer. Ring-opening metathesis polymerization (ROMP) of the norbornenyl macromonomer using Grubbs catalyst, (H 2 IMes)(pyr) 2 (Cl) 2 Ru = CHPh (G3), resulted in well-defined bottlebrush polymers in a highly efficient way. We studied the polymerization behavior and characterized the single chain conformation of the bottlebrush polymers in dilute solution together with coarse-grained molecular dynamics (CG-MD) simulation. Photoluminescence investigation of the bottlebrush polymers in dilute solution revealed the expected AIE phenomenon, thus verifying the steric crowding effects within bottlebrush polymers. This work bridges AIE technology with polymer science and especially bottlebrush polymers. By doing this, our research not only broadens the bottlebrush polymer library but also provides insights into bottlebrush polymer chain study for potential applications.}, archive = {J_ANGEW}, author = {Lei Wu and Ulrich Glebe and Kyan T. K. Kwok and Jianwei Sun and Jacky W. Y. Lam and Ben Zhong Tang}, doi = {10.1002/anie.202500850}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500850}, shortjournal = {Angew. Chem. Int. Edit.}, title = {AIE bottlebrush polymers: Verification of internal crowdedness in bottlebrush polymers using the AIE effect}, volume = {64}, year = {2025}, }
• (2025). “Pulsed” chain transfer anionic polymerization: A green and cost-effective approach for controlled polymer synthesis. ANGEW, 64(19), e202500761. (www)

  @article{ , abstract = {Herein, we report a method that significantly enhances the atom economy of catalysts in living polymerization. By introducing intermittent, switchable chain-transfer reactions during the polymerization process, multiple regenerations of the catalyst are achieved while preserving the “living”/controlled characteristics. The specially designed catalytic system, composed of 1,2-dipyrrolidinoethane/n-butyllithium/n-butylpotassium/toluene, exhibits a chain-transfer rate that is highly sensitive to temperature. It enables living polymerization at low temperatures, while at high temperatures, rapid chain transfer to toluene occurs. Utilizing this characteristic, polymerization is initially carried out at low temperatures; once the monomer is consumed, increasing the temperature promotes chain transfer, resulting in initiator regeneration. The regenerated initiator can then initiate new cycles of living polymerization upon the addition of fresh monomers. This process was repeated for more than a dozen cycles, achieving an initiator efficiency of up to 1500%. Using this method, we successfully synthesized polybutadiene and styrene-butadiene copolymer with an extremely narrow molecular weight distribution ( Đ = 1.1). The mechanism was investigated by in situ NMR spectroscopy, MALDI-TOF-MS, and DFT calculations. This approach is particularly well-suited for the controllable, green, and cost-effective production of low- to medium-molecular-weight polymers and block copolymers.}, archive = {J_ANGEW}, author = {Jian Tang and Yudong Liu and Jinhui Liu and Jiahao Zhang and Zhongyang Xie and Jing Hua and Zhibo Li}, doi = {10.1002/anie.202500761}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500761}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Pulsed” chain transfer anionic polymerization: A green and cost-effective approach for controlled polymer synthesis}, volume = {64}, year = {2025}, }
• (2025). Artificial photosynthesis of formamide via an oxidant-free photoinduced radical coupling route over pt-CdS. ANGEW, 64(19), e202500747. (www)

  @article{ , abstract = {Large-scale manufacturing of formamide is always involved with the use of carbon monoxide, hence developing a series of eco-friendly synthesis routes is of great significance. Alternative feedstock of low-cost methanol is expected to fulfill this breakthrough due to its green and renewable nature; however, the overoxidation of methanol severely inhibits the efficacious formamide synthesis from methanol and ammonia through the conventional catalytic route. Herein, we report the successful development of a direct radical coupling route for converting methanol and ammonia into high-selectivity formamide and hydrogen without extra oxidants under ambient conditions. The optimized Pt-CdS photocatalysts offered an impressive formamide production rate of 1.45 mmol g −1 h −1 , as well as an exceptional hole selectivity reaching up to 63.5%. The oxidant-free radical mechanism of high-efficiency formamide generation as revealed by in situ characterizations (e.g., in situ electron paramagnetic resonance and in situ transient absorption spectroscopy), stems from the photogenerated holes oxidizing the methanol to hydroxymethyl radical for subsequently direct C─N coupling with amino radical. This work demonstrates an efficient oxidant-free photoinduced radical coupling strategy with the promise of an acceptable alternative to current technologies for artificial photosynthesis formamide using clean and abundant solar energy.}, archive = {J_ANGEW}, author = {Junyu Gao and Jinhu Wang and Dong Li and Guangliu Ran and Wenkai Zhang and Li-Zhu Wu and Yunxuan Zhao and Tierui Zhang}, doi = {10.1002/anie.202500747}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500747}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial photosynthesis of formamide via an oxidant-free photoinduced radical coupling route over pt-CdS}, volume = {64}, year = {2025}, }
• (2025). Exploiting antisite defects in FeWN2 nanosheets for enol electro-oxidation coupled with h2 evolution at a large current density. ANGEW, 64(19), e202500678. (www)

  @article{ , abstract = {Hydrogen production from biomass electro-oxidation offers a promising alternative to water electrolysis by lowering the anodic oxidation barrier and producing valuable chemicals. However, current biomass electro-oxidation systems have difficulties in achieving an industrial-scale current density due to the difficulty in cleaving high-energy C─H and O─H bonds. Here, we report a ternary layer nitride FeWN 2 electrocatalyst with abundant antisite defects (ASDs), which significantly improves its electrocatalytic performance for ascorbic acid (AA) oxidation. The catalyst works at a remarkable current density of 2.5 A cm −2 at 0.69 V (vs RHE) and achieves 4 A cm −2 at 1.12 V in a two-electrode electrolyzer at 60 °C with 100% Faraday efficiency for H 2 production. Theoretical calculations reveal that W atoms near antipodal Fe sites replenish the electron density of Fe, maintaining moderate Fe-DHA adsorption strength induced by ASDs that achieve superior catalytic efficiency for AA-to-DHA conversion This study provides new insight for developing high-performance organic oxidation catalysts with ASDs.}, archive = {J_ANGEW}, author = {Zheng-Jie Chen and Qiting Shao and Jiajing Wu and Jian Zheng and Shida Bao and Lili Zhang and Tao Zhang and Xuexia Lan and Yuanmiao Sun and Dawei Wang and Jing Peng and Hui-Ming Cheng}, doi = {10.1002/anie.202500678}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500678}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploiting antisite defects in FeWN2 nanosheets for enol electro-oxidation coupled with h2 evolution at a large current density}, volume = {64}, year = {2025}, }
• (2025). Photoexcited structural diversification of carboxylic acids with phosphorus promoter. ANGEW, 64(19), e202500657. (www)

  @article{ , abstract = {Photoexcitation of carboxylic acids is challenging due to high energy requirements and low quantum efficiency. Recently, Scheidt and co-workers reported a single-flask transformation of carboxylic acids into acyl phosphonates, which facilitates the generation of diradicals under visible light irradiation. Building on this work, an efficient strategy for the structural reconstruction of carboxylic acids has been developed.}, archive = {J_ANGEW}, author = {Wei Zhang and Wenhui Zhu and Jin-Dong Yang}, doi = {10.1002/anie.202500657}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500657}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoexcited structural diversification of carboxylic acids with phosphorus promoter}, volume = {64}, year = {2025}, }
• (2025). Photo- and cerium-mediated C─C bond cleavage for the deconstructive diversification of cyclic acids. ANGEW, 64(19), e202500561. (www)

  @article{ , abstract = {The selective cleavage of inert carbon-carbon bonds in unstrained rings continues to pose a formidable challenge in chemical synthesis. Current methods for C(sp 3 ) ─C(sp 3 ) bond cleavage are highly limited, typically relying on transition-metal catalysis to facilitate ring-opening via small-ring strain or inducing β-fragmentation after generating radicals from oxygen or nitrogen atoms pre-installed in the substrate. Herein, we introduce an effective strategy for the decarboxylative ring-opening functionalization of α-trisubstituted carboxylic acids, mediated by both light and cerium. This method enables the ring-opening of carboxylic acids with ring sizes ranging from 3 to 12 members, allowing the construction of C─CN, C-halide, C─C, C─Se, and C─oxime bonds. Notably, this reaction does not require the pre-installation of an oxygen atom in the substrate, as the carbonyl group is derived from atmospheric oxygen. Furthermore, late-stage modification establishes distally functionalized carbonyl compounds, which serve as versatile synthons for accessing valuable building blocks.}, archive = {J_ANGEW}, author = {Yan Xu and Jianjie Wang and Qian Zhang and Xinyao Hu and Chun Lv and Heng Yang and Bin Sun and Can Jin}, doi = {10.1002/anie.202500561}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500561}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo- and cerium-mediated C─C bond cleavage for the deconstructive diversification of cyclic acids}, volume = {64}, year = {2025}, }
• (2025). LIBX-a401: A novel selective inhibitor of acyl-CoA synthetase long chain family member 4 (ACSL4) and its binding mode. ANGEW, 64(19), e202500518. (www)

  @article{ , abstract = {Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4), a pivotal enzyme in lipid metabolism, has emerged as a therapeutic target for ferroptosis-related conditions and cancer. However, its reference inhibitor, rosiglitazone, has off-target activity on peroxisome proliferator-activated receptor gamma (PPARγ), a key regulator of lipid homeostasis. Here, the discovery of LIBX-A401, a potent ACSL4 inhibitor derived from rosiglitazone devoid of PPARγ activity, is reported. Its binding to ACSL4 is ATP-dependent, stabilizing the C-terminal domain and altering the fatty acid gate region, as shown by Hydrogen-Deuterium Exchange Mass Spectrometry. Photoaffinity labeling identified A329 within the fatty acid binding site, while molecular dynamics and mutagenesis highlighted Q302 as critical for LIBX-A401 binding. LIBX-A401 exhibits anti-ferroptotic properties in cells, supported by target engagement. These findings establish LIBX-A401 as a valuable tool to study ACSL4 in ferroptosis and cancer, while its elucidated binding mode paves the way for the rational design of improved inhibitors.}, archive = {J_ANGEW}, author = {Darius Mazhari Dorooee and Séverine Ravez and Didier Vertommen and Nicolas Renault and Nicolas Papadopoulos and Romain Marteau and Emeline Charnelle and Karine Porte and Alexandre Gobert and Nathalie Hennuyer and Gaetan Herinckx and Maëla Pautric and Aurélie Jonneaux and Jean Christophe Devedjian and David Devos and Bart Staels and Patricia Melnyk and Stefan N. Constantinescu and Raphaël Frédérick and Jamal El Bakali}, doi = {10.1002/anie.202500518}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500518}, shortjournal = {Angew. Chem. Int. Edit.}, title = {LIBX-a401: A novel selective inhibitor of acyl-CoA synthetase long chain family member 4 (ACSL4) and its binding mode}, volume = {64}, year = {2025}, }
• (2025). Controlled anodic decomposition pathway of supramolecular lithium borate for rationally tuned interphase chemistry. ANGEW, 64(19), e202500425. (www)

  @article{ , abstract = {The rational tailoring and molecular-level engineering of stable cathode-electrolyte interphases (CEIs) is paramount to advancing the performance of next-generation high-energy, layered nickel-rich oxide-based lithium metal batteries. However, developing well-tailored electrolyte additives with rationally controlled interfacial chemistry remains highly challenging. Here, two lithium borates: lithium (2-methoxy-15-crown-5)trifluoroborate (C-LiMCFB) and lithium (15-methoxy-2,5,8,11,14-pentaoxahexadecan)trifluoroborate (L-LiMCFB), incorporating cyclic 15-crown-5 (15C5) and linear pentaethylene glycol monomethyl ether (PEGME) as respective host groups tethered to the boron center are designed and synthesized. In C-LiMCFB, the supramolecular polydentate chelation/de-chelation of the 15C5 with Li + can sequentially deactivate/activate the anodic decomposition of the C─O bonds, therefore leading to the controlled cleavage pathway of B─O and C─O bonds. The controlled interfacial chemistry leads to the formation of a uniform CEI layer, rich in lithium boron–oxygen clusters interwoven with LiF, on the NCM811 surface. This novel CEI configuration demonstrates an exceptional balance of mechanical robustness, adhesiveness, and toughness, providing highly desirable protection for the NCM811 cathode. The discovery of these novel supramolecular boron-based lithium salts not only unlocks supramolecular chemistry for rational electrolyte tuning but also provides a deeper understanding of the CEI formation mechanism in high-energy lithium metal batteries.}, archive = {J_ANGEW}, author = {Haiyu Zhou and Wenhui Hou and Da Zhu and Pan Zhou and Xuwen Peng and Zhi Liu and Shuaishuai Yan and Yang Lu and Yu Ou and Fengxiang Liu and Yingchun Xia and Hao Liu and Qingbin Cao and Xuan Song and Decai Guo and Hong Xu and Kai Liu}, doi = {10.1002/anie.202500425}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500425}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled anodic decomposition pathway of supramolecular lithium borate for rationally tuned interphase chemistry}, volume = {64}, year = {2025}, }
• (2025). Advancing propylene epoxidation: The role of ethyl acetate autoxidation via cobalt-nickel catalyzed C(acyl)─O bond scission. ANGEW, 64(19), e202500384. (www)

  @article{ , abstract = {The selective autoxidation for the synthesis of valuable oxygenates has provoked keen interest from both academic and industrial sectors. Although the generation of reactive oxygen species via oxygen attack on C─H bonds near ester linkages is well-established, research into aliphatic ester oxidation has primarily focused on combustion, neglecting their potential utility in oxidation processes. Herein, a protocol for producing propylene oxide through the autoxidation of ethyl acetate in tandem with propylene epoxidation is demonstrated. The ethoxy radical, generated by ester C(acyl)─O bond cleavage in situ, subsequently underwent proton-coupled electron transfer with the Co(OAc)( μ -H 2 O) 2 Ni, followed by the formation of the peracetic acid optimally suited for the epoxidation reaction. The research not only eliminates the need for co-substrates in the epoxidation process but also fills the application gap in bulk-ester autoxidation, offering insights into the effective utilization of oxy-intermediates in autoxidation reactions.}, archive = {J_ANGEW}, author = {Yaorong He and Chao Xiong and Luotian Lv and Dongpo Li and Sixuan Shi and Can Xue and Hongbing Ji}, doi = {10.1002/anie.202500384}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500384}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Advancing propylene epoxidation: The role of ethyl acetate autoxidation via cobalt-nickel catalyzed C(acyl)─O bond scission}, volume = {64}, year = {2025}, }
• (2025). Assembly of functionalized organic fragments via reductive activation and (Cross)-coupling of C2H4, CO, CO2 and/or h2 using a magnesium-dinitrogen complex. ANGEW, 64(19), e202500264. (www)

  @article{ , abstract = {Reactions of 1,2-dimagnesioethane compound [{K( TCHP NON)Mg} 2 (μ-C 2 H 4 )] ( TCHP NON = 4,5-bis(2,4,6-tricyclohexylanilido)-2,7-diethyl-9,9-dimethyl-xanthene), formed by the two-electron reduction of ethene with a dimagnesium/dipotassium complex of reduced N 2 , viz. [{K( TCHP NON)Mg} 2 (μ-N 2 )], with CO and CO 2 have been explored. In the case of the reaction with CO, cross-coupling of the reduced ethene fragment with two molecules of CO gave a heterobimetallic complex of the parent cyclobutenediolate dianion, [{K( TCHP NON)Mg} 2 (μ-O 2 C 4 H 4 )], which when exposed to THF gave adduct [{K( TCHP NON)Mg} 2 (μ-O 2 C 4 H 4 )(THF)]. Treating [{K( TCHP NON)Mg} 2 (μ-C 2 H 4 )] with CO 2 led to the insertion of CO 2 into both Mg─C bonds and all Mg─N bonds, yielding a magnesium succinate complex, [{K( TCHP NON-C 2 O 4 )Mg} 2 (μ-O 4 C 4 H 4 )], in which the diamide ligands have been converted to xanthene bridged dicarbamates. The reaction of [{K( TCHP NON)Mg} 2 (μ-N 2 )] with CO 2 , proceeded via reductive coupling of the heterocumulene to give the oxalate dianion, in addition to the insertion of CO 2 into all Mg─N bonds of the magnesium-dinitrogen complex, forming dimeric [{K( TCHP NON-C 2 O 4 )Mg} 2 (μ-O 4 C 2 )] 2 . When treated with THF this yields monomeric [{K(THF)( TCHP NON-C 2 O 4 )Mg(THF)} 2 (μ-O 4 C 2 )]. Related chemistry results from the reaction of a dianionic magnesium(I) compound with CO 2 . In contrast, C─C bond formation was not observed in the reaction of [{K( TCHP NON)Mg} 2 (μ-N 2 )] with a CO 2 analog, i.e., the carbodiimide CyNCNCy (Cy = cyclohexyl). Instead, H abstraction by a proposed radical intermediate gave polymeric formamidinate complex [K( TCHP NON)Mg{(CyN) 2 CH}] ∞ . Reaction of CO 2 with the magnesium hydride complex [{K( TCHP NON)Mg(μ-H)} 2 ] gave the unusual trimeric magnesium formate complex [{K( TCHP NON-CO 2 )Mg}(μ-O 2 CH)] 3 in which CO 2 has inserted into only one Mg─N bond of each TCHP NON ligand. This study highlights the capacity of [{K( TCHP NON)Mg} 2 (μ-N 2 )] to act as a masked dimagnesium(I) diradical in reductive coupling or cross-coupling of the simple gaseous reagents, C 2 H 4 , CO, CO 2 and H 2 , to give value-added organic fragments.}, archive = {J_ANGEW}, author = {Dat T. Nguyen and Rahul Mondal and Matthew J. Evans and Joseph M. Parr and Cameron Jones}, doi = {10.1002/anie.202500264}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500264}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Assembly of functionalized organic fragments via reductive activation and (Cross)-coupling of C2H4, CO, CO2 and/or h2 using a magnesium-dinitrogen complex}, volume = {64}, year = {2025}, }
• (2025). In situ high selectivity contact-electroreduction of CO2 to methanol using an imine-mediated metal-free vitrimer catalyst. ANGEW, 64(19), e202500222. (www)

  @article{ , abstract = {Metal catalysts for the CO 2 reduction reaction (CO 2 RR) face challenges such as high cost, limited durability, and environmental impact. Although various structurally diverse and functional metal-free catalysts have been developed, they often suffer from slow kinetics, low selectivity, and nonrecyclability, significantly limiting their practical applications. In this study, we introduce a recyclable nonmetallic polymer material (vitrimer) as a catalyst for a new platform in contact-electrocatalysis. This approach harnesses the contact charges generated between water droplets and vitrimer to drive CO 2 RR, achieving methanol selectivity exceeding 90%. The imine groups within the vitrimer play a dual role, facilitating CO 2 adsorption and enriching friction-generated electrons, thereby mediating efficient electron transfer between the imine groups and CO 2 to promote CO 2 RR. After 84 h of CO 2 RR, the system achieved a methanol production rate of 13 nmol·h −1 , demonstrating the excellent stability of the method. Moreover, the vitrimer retains its high-performance electrocatalytic activity even after recycling. Mechanistic studies reveal that, compared to traditional metal catalysts, the N─O bond in the imine, which adsorbs the key intermediate *OCH 3 , breaks more readily to produce methanol, resulting in enhanced product selectivity and yield. This efficient and environmentally friendly contact-electroreduction strategy for CO 2 offers a promising pathway toward a circular carbon economy by leveraging natural water droplet-based contact-electrochemistry.}, archive = {J_ANGEW}, author = {Nannan Wang and Haisong Feng and Jing Yang and Jie Zheng and Yong-Wei Zhang and Nikos Hadjichristidis and Zibiao Li}, doi = {10.1002/anie.202500222}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500222}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ high selectivity contact-electroreduction of CO2 to methanol using an imine-mediated metal-free vitrimer catalyst}, volume = {64}, year = {2025}, }
• (2025). Size-controlled self-assembly for bimodal in vivo imaging. ANGEW, 64(19), e202500144. (www)

  @article{ , abstract = {Contrast agents (CAs) are essential in biomedical imaging to aid in the diagnosis and therapy monitoring of disease. However, they are typically restricted to one imaging modality and have fixed properties such as size, shape, toxicity profile, or photophysical characteristics, which hampers a comprehensive view of biological processes. Herein, rationally designed dye assemblies are introduced as a unique CA platform for simultaneous multimodal and multiscale biomedical imaging. To this end, a series of amphiphilic aza-BODIPY dyes are synthesized with varying hydrophobic domains ( C 1 , C 8 , C 12, and C 16 ) that self-assemble in aqueous media into nanostructures of tunable size (50 nm–1 µm) and photophysical properties. While C 1 exhibits oblique-type exciton coupling and negligible emission, C 8 - C 16 bearing longer alkyl chains undergo J -type aggregation with NIR absorption and emission and excellent photoacoustic properties. Given these advantageous features, aza-BODIPY specific, semi-quantitative fluorescence reflectance and photoacoustic imaging both in vitro and in vivo are established. Additionally, in vitro cell viability as well as murine in vivo biodistribution analysis with ex vivo validation showed excellent biocompatibility and a size-dependent biodistribution of nanostructures to different organ beds. These results broaden the scope of aqueous self-assembly to multimodal imaging and highlight its great potential for rationalizing numerous biomedical questions.}, archive = {J_ANGEW}, author = {Antonia Albers and Shivadharshini Kuberasivakumaran and Zulema Fernández and Constantin G. Daniliuc and Yongsheng Li and Myongsoo Lee and Christiane Geyer and Emily Hoffmann and Cornelius Faber and Anne Helfen and Carsten Grashoff and Max Masthoff and Gustavo Fernández}, doi = {10.1002/anie.202500144}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Size-controlled self-assembly for bimodal in vivo imaging}, volume = {64}, year = {2025}, }
• (2025). Cleavable strand-fusing cross-linkers as additives for chemically deconstructable thermosets with preserved thermomechanical properties. ANGEW, 64(19), e202500104. (www)

  @article{ , abstract = {Permanently cross-linked polymer networks—thermosets—are often difficult to chemically deconstruct. The installation of cleavable bonds into the strands of thermosets using cleavable comonomers as additives can facilitate thermoset deconstruction without replacement of permanent cross-links, but such monomers can lead to reduced thermomechanical properties and require high loadings to function effectively, motivating the design of new and optimal cleavable additives. Here, we introduce “strand-fusing cross-linkers” (SFCs), which fuse two network strands via a four-way cleavable cross-link. SFCs enable deconstruction of model polydicyclopentadiene (pDCPD) thermosets with as little as one-fifth of the molar loading needed to achieve deconstruction using traditional cleavable comonomers. SFCs function under traditional oven curing as well as low-energy frontal ring-opening metathesis polymerization (FROMP) conditions and lead to improved thermomechanical properties, for example, glass transition temperatures, compared to prior cleavable comonomer designs. This work motivates the development of increasingly improved cleavable additives to enable thermoset deconstruction without compromising material performance.}, archive = {J_ANGEW}, author = {Shuyi Zhang and Zhenchuang Xu and Keith E. L. Husted and David J. Lundberg and Christopher M. Brown and Yuyan Wang and Peyton Shieh and Kwangwook Ko and Jeffrey S. Moore and Jeremiah A. Johnson}, doi = {10.1002/anie.202500104}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cleavable strand-fusing cross-linkers as additives for chemically deconstructable thermosets with preserved thermomechanical properties}, volume = {64}, year = {2025}, }
• (2025). Spiro-driven ferroelectric coordination polymer exhibiting distinct phase transitions under thermal and pressure stimuli. ANGEW, 64(19), e202500027. (www)

  @article{ , abstract = {Controllable strategies for the design of molecular ferroelectrics have been actively pursued in recent years due to their promising applications in modern electronic devices. In this work, we present a spiro-driven approach for the design of a new class of molecular ferroelectrics. Using 2-morpholinoethanol (MEO) as a bidentate chelating ligand and the SCN⁻ anion as a bridging co-ligand, we obtained a neutral chain-like ferroelectric coordination polymer, [Cd(MEO)(SCN) ₂ ]. Interestingly, it undergoes both a thermal-induced phase transition, driven by ring-conformational flipping of the spiro-like [Cd(MEO)] fragment, and a pressure-induced transition, triggered by significant deformation of the spring-like [Cd(SCN) ₂ ] ∞ helical chain. Unlike most previously reported ferroelectric coordination polymers, which often rely on organic cationic guests, this work introduces a new avenue for designing neutral ferroelectric coordination polymers. Overall, the spiro-driven strategy provides valuable insights and a novel structural motif for the development of advanced molecular ferroelectrics.}, archive = {J_ANGEW}, author = {Zi-Yi Du and Miao Xie and Wenbo Qiu and Ding-Chong Han and Shi-Yong Zhang and Ying Zeng and Weizhao Cai and Takayoshi Nakamura and Rui-Kang Huang and Chun-Ting He}, doi = {10.1002/anie.202500027}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202500027}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spiro-driven ferroelectric coordination polymer exhibiting distinct phase transitions under thermal and pressure stimuli}, volume = {64}, year = {2025}, }
• (2025). Regulating the dynamics of interpenetrated porous frameworks for inverse C2H6/C2H4 separation at elevated temperature. ANGEW, 64(19), e202425638. (www)

  @article{ , abstract = {Selective adsorption of ethane (C 2 H 6 ) from mixtures containing ethylene (C 2 H 4 ) is of interest for the direct production of high purity C 2 H 4 . However, the extremely similar molecular properties of these gases make this process challenging, particularly at elevated temperatures, an implication of saved energy consumption. To address such challenge, we present a new approach for regulating the temperature-dependent dynamics in hydrogen-bonded interpenetrated frameworks. As a single H-bond linked interpenetrated porous framework, NTU-101-NH 2 exhibits emerging structural dynamics in response to C 2 H 6 (37 kPa) and C 2 H 4 (53 kPa) and has shown a record ability to produce polymer-grade C 2 H 4 (15.7 mL g −1 ) at 328 K, as the shifting of the interpenetrated frameworks here requires a relatively weak stimulus, allowing the optimization of adsorption at a higher temperatures range. Meanwhile, the robust and conveniently prepared NTU-101-NH 2 shows good cyclic separation performance. In comparison, the framework response of the percussor NTU-101 , connected by three H-bonds, occurs at 293 K and has a moderate separation ability (10.2 mL g −1 ). This work showcases the first adsorbent for direct C 2 H 4 purification at elevated temperatures, and the insights into the hydrogen-bonded frameworks will pave the way for designing soft families capable of challenging separations with reduced energy requirements.}, archive = {J_ANGEW}, author = {Wei Yang and Jiaqi Wang and Kui Tan and Hao-Long Zhou and Muyu Zhang and Rajamani Krishna and Jingui Duan and Ling Huang}, doi = {10.1002/anie.202425638}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425638}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating the dynamics of interpenetrated porous frameworks for inverse C2H6/C2H4 separation at elevated temperature}, volume = {64}, year = {2025}, }
• (2025). Spin polarization-boosting ultrafast carrier dynamics and exciton dissociation in fe nanoparticle-loading graphitic carbon nitride toward efficient CO2 photoreduction. ANGEW, 64(19), e202425630. (www)

  @article{ , abstract = {The regulation of exciton properties plays a crucial role in enhancing the activity of photocatalysts, primarily due to the rapid recombination of photoinduced electron–hole pairs caused by the strong Coulomb interaction between them. In this study, we explore the spin polarization effect in nanohybrids composed of graphitic carbon nitride (g-C₃N₄) and iron (Fe) nanoparticles, which accelerates exciton dissociation and spin-selective electron transfer, thereby improving the selective photoreduction of CO₂ into CO. Mechanistic studies reveal that the Fe 2 ⁺/Fe 3 ⁺ redox pairs, embedded in the iron oxide layer on the surface of Fe nanoparticles, function as ultrafast charge transfer shuttles via a double exchange interaction (Fe 2 ⁺─O─Fe 3 ⁺). This process facilitates spin-selective electron transfer from g-C₃N₄ to Fe species, thereby contributing to the efficient conversion of CO₂. This work provides novel insights into the design of spin-dependent photocatalysts for efficient solar energy conversion.}, archive = {J_ANGEW}, author = {Haoqiang Chi and Yecheng Leng and Cheng Ding and Tianhao Li and Yongcai Zhang and Junyang Yuan and Wenguang Tu and Wa Gao and Yingfang Yao and Xi Zhu and Yong Zhou and Zhigang Zou}, doi = {10.1002/anie.202425630}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425630}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spin polarization-boosting ultrafast carrier dynamics and exciton dissociation in fe nanoparticle-loading graphitic carbon nitride toward efficient CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). High-density post-perovskite for ultra-sensitive hard X-ray detection. ANGEW, 64(19), e202425448. (www)

  @article{ , abstract = {The density properties of semiconductors play a crucial role in applications, such as radiation detection, electronic devices, and aerospace technologies. However, controlling the density of semiconductors often leads to significant alterations in their electronic structure, which can result in the loss of their original semiconductor properties. Perovskite semiconductors, known for their excellent carrier transport properties, face limitations in hard X-ray detection due to their relatively low density and loose atomic packing. This study explores a series of post-perovskite semiconductors with densities exceeding 5 g cm⁻ 3 , achieved through edge- and face-sharing connectivity of octahedra and strong polarization between metal and chalcogenide ions. These dense materials retain semiconductor properties while exhibiting superior electrical transport characteristics. When applied to hard X-ray detection, the post-perovskite materials demonstrated superior attenuation cross-sections compared to the heaviest 3D CsPbI 3 perovskite and 0D Cs 3 Bi 2 I 9 perovskite. Specifically, the BiCuSCl 2 post-perovskite detector exhibited a high sensitivity of 4126 µC Gy air −1 cm −2 and a minimum detection limit of 4.3 nGy air s −1 . The enhanced density also mitigates ionic migration, ensuring excellent electrical stability. These findings underscore the potential of post-perovskite semiconductors for advanced optoelectronic and radiation detection applications.}, archive = {J_ANGEW}, author = {Mengling Xia and Yuzhu Li and Chenxing Li and Yinsheng Xu and Guangda Niu}, doi = {10.1002/anie.202425448}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425448}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-density post-perovskite for ultra-sensitive hard X-ray detection}, volume = {64}, year = {2025}, }
• (2025). Isoselenourea-catalyzed enantioselective pyrazolo-heterocycle synthesis enabled by self-correcting amide and ester acylation. ANGEW, 64(19), e202425305. (www)

  @article{ , abstract = {Pyrazole heterocycles are prevalent in a wide range of medicinal and agrochemical compounds, and as such, the development of methods for their enantioselective incorporation into molecular scaffolds is highly desirable. This manuscript describes the effective formation of fused pyrazolo-pyridones and -pyranones in high enantioselectivity (up to >99:1 er) via an isoselenourea (HyperSe) catalyzed enantioselective [3 + 3]-Michael addition-cyclization process using readily available pyrazolylsulfonamides or pyrazolones as pronucleophiles and α,β-unsaturated anhydrides as starting materials. Mechanistic analysis indicates an unusual self-correcting reaction pathway involving preferential [1,2]-addition of the pronucleophile to initially generate an intermediate amide or ester that can be intercepted by isoselenourea acylation, leading to productive formation of the fused heterocyclic products with high enantiocontrol. The scope and limitations of this process are developed across a range of examples, with insight into the factors leading to the observed enantioselectivity provided by density functional theory (DFT) analysis.}, archive = {J_ANGEW}, author = {Martha I. Prindl and Matthew T. Westwood and Alister S. Goodfellow and Aidan P. McKay and David B. Cordes and Michael Bühl and Andrew D. Smith}, doi = {10.1002/anie.202425305}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425305}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isoselenourea-catalyzed enantioselective pyrazolo-heterocycle synthesis enabled by self-correcting amide and ester acylation}, volume = {64}, year = {2025}, }
• (2025). Regio- and enantioconvergent hydroallylation of acrylates enabled by γ-silyl-substituted allyl acetates. ANGEW, 64(19), e202425256. (www)

  @article{ , abstract = {Transition-metal-catalyzed asymmetric allylic substitution provides an efficient route to chiral organic molecules featuring an allyl moiety, key intermediates in the synthesis of biologically active compounds. However, the use of unsymmetrical 1,3-disubstituted allyl electrophiles has been severely constrained by the challenges of achieving both regio- and stereoselectivity simultaneously. Herein, we present γ-silyl-substituted allyl acetates as highly effective electrophiles for a regio- and enantioconvergent hydroallylation, enabling the construction of vicinal stereogenic centers. This method delivers allylated products in 44%–93% yield with 79:21 to >95:5 dr and 88% to >99% ee. Additionally, the silyl group in the products can be readily converted into other functional groups, such as acyl and aryl groups, enhancing their synthetic utility.}, archive = {J_ANGEW}, author = {Hirotsugu Suzuki and Ryoichi Nishikawa and Yuki Sato and Kaisei Sekino and Takanori Matsuda}, doi = {10.1002/anie.202425256}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425256}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regio- and enantioconvergent hydroallylation of acrylates enabled by γ-silyl-substituted allyl acetates}, volume = {64}, year = {2025}, }
• (2025). Mechanistic insights into H2O dissociation in overall photo-/Electro-catalytic CO2 reduction. ANGEW, 64(19), e202425195. (www)

  @article{ , abstract = {Photo-/electro-catalytic CO 2 reduction with H 2 O to produce fuels and chemicals offers a dual solution to address both environmental and energy challenges. For a long time, catalyst design in this reaction system has primarily focused on optimizing reduction sites to improve the efficiency or guide the reaction pathway of the CO 2 reduction half-reaction. However, less attention has been paid to designing activation sites for H 2 O to modulate the H 2 O dissociation half-reaction. Impressively, the rate-determining step in overall CO 2 reduction is the latter, and it influences the evolution direction and formation energy of carbon-containing intermediates through the proton-coupled electron transfer process. Herein, we summarize the mechanism of the H 2 O dissociation half-reaction in modulating CO 2 reduction performance based on cutting-edge research. These analyses aim to uncover the potential regulatory mechanisms by which H 2 O activation influences CO 2 reduction pathways and conversion efficiency, and to establish a mechanism-structure-performance relationship that can guide the design and development of high-efficiency catalytic materials. A summary of advanced characterization techniques for investigating the dissociation mechanism of H 2 O is presented. We also discuss the challenges and offer perspectives on the future design of activation sites to improve the performance of photo-/electro-catalytic CO 2 reduction.}, archive = {J_ANGEW}, author = {Minzhi Ma and Yuanxing Fang and Zeai Huang and Sixin Wu and Weiwei He and Suxiang Ge and Zhi Zheng and Ying Zhou and Wenjun Fa and Xinchen Wang}, doi = {10.1002/anie.202425195}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425195}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanistic insights into H2O dissociation in overall photo-/Electro-catalytic CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Homologation of alkenes using acetylene as a c2 feedstock. ANGEW, 64(19), e202425169. (www)

  @article{ , abstract = {The preparation of diverse homologs from lead compounds has been a common and important practice in medicinal, mechano, polymeric, and many other branches of chemistry. The homologation of alkenes, though important, remains challenging due to the difficulty of (CH 2 ) n insertion into the main carbon chain of alkenes compared to chains containing other polar functional groups. Here, we report the homologation of both terminal and internal alkenes by using acetylene as a cheap and abundant C 2 feedstock. The process involves an in-situ transformation of alkenes into boranes and then into elongated alkenes, during which direct (CH 2 ) n insertion is avoided. The reaction can be carried out iteratively to achieve up to a 12-carbon elongation.}, archive = {J_ANGEW}, author = {Tairan Cheng and Siju Li and Jiayao Qiu and Zedong Yang and Huanfeng Jiang and Shifa Zhu}, doi = {10.1002/anie.202425169}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Homologation of alkenes using acetylene as a c2 feedstock}, volume = {64}, year = {2025}, }
• (2025). Size effect of surface defects dictates reactivity for nitrogen electrofixation. ANGEW, 64(19), e202425112. (www)

  @article{ , abstract = {Electrocatalytic nitrogen reduction reaction (eNRR) offers a sustainable pathway for ammonia (NH 3 ) production. Defect engineering enhances eNRR activity but can concurrently amplify the competing hydrogen evolution reaction (HER), posing challenges for achieving high selectivity. Herein, VO x with systematically tuned defect sizes is engineered to establish a structure–activity relationship between defect size and eNRR performance. In situ spectroscopy and theoretical calculations reveal that medium-sized defects (VO x -MD, 1–2 nm) provide an optimal electronic environment for enhanced N 2 adsorption and activation while maintaining spatial flexibility to facilitate efficient hydrogenation. Consequently, VO x -MD exhibits outstanding eNRR performance, achieving an NH 3 yield rate of 81.94 ± 1.45 µg h −1 mg −1 and a Faradaic efficiency of 31.97 ± 0.75 % at −0.5 V (vs RHE). These findings highlight the critical role of defect size in governing eNRR activity, offering a scalable strategy for designing advanced catalysts for competitve electrocatalytic reactions.}, archive = {J_ANGEW}, author = {Yuntong Sun and Gonggong Lu and Zhiqi Wang and Xuheng Li and Yinghao Li and Nicole L. D. Sui and Wenjun Fan and Ao Wang and Bo Yuan and Junjie Wang and Jong-Min Lee}, doi = {10.1002/anie.202425112}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Size effect of surface defects dictates reactivity for nitrogen electrofixation}, volume = {64}, year = {2025}, }
• (2025). Single-molecule solvolysis reaction dynamics under electrostatic catalysis and proton tunneling. ANGEW, 64(19), e202425097. (www)

  @article{ , abstract = {A central goal of chemical mechanism research is to provide a comprehensive interpretation of chemical reaction pathways to clarify the evolution patterns of reactions. In this work, we present an unprecedented comprehensive monitoring of the elementary reaction pathways of the S N 1 solvolysis on an in situ real-time single-molecule electrical detection platform. Through precise control of oriented external electric fields, we capture two short-lived protonated intermediates at the single-molecule level and elucidate their roles in the reaction. Both temperature- and isotope-dependent experiments, in combination with theoretical simulations, reveal crucial roles for the hydrogen-bonded acetic-acid-mediated triple-proton-transfer and the proton tunneling effect in the interconversion of these two intermediates. This work highlights the precise manipulation of chemical reactions by electrostatic fields and opens up a universal route to discover unknown intermediates or novel phenomena in the processes of material transformation and life activities.}, archive = {J_ANGEW}, author = {Xinmiao Xie and Jiajia Yang and Yong Yan and Jie Hao and Chen Yang and Yilin Guo and Haobin Wang and Bingchen Zhong and Wei Huang and Ganglong Cui and Weihai Fang and Linghai Xie and Xuefeng Guo}, doi = {10.1002/anie.202425097}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202425097}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-molecule solvolysis reaction dynamics under electrostatic catalysis and proton tunneling}, volume = {64}, year = {2025}, }
• (2025). Why mental health literacy can improve STEM. ANGEW, 64(19), e202424871. (www)

  @article{ , abstract = {In recent years, an increasing number of articles have outlined the mental health crisis in academia. Despite its widely appreciated significance, most of the related research is published in journals focusing on education, social science, psychology, or psychiatry. Despite stakeholders in science, technology, engineering, and mathematics (STEM) being disproportionately affected, they are often left in the dark about important findings unless they seek out relevant information themselves. This contribution attempts to spark interdisciplinary discussion between psychology, psychiatry, and STEM by highlighting relevant research, advocating for increased knowledge on mental health, and elaborating on what benefits improved mental health literacy could have for both the individual and the academic system in its entirety.}, archive = {J_ANGEW}, author = {Christian W. Pester and Klaus Lieb and Sarah K. Schäfer}, doi = {10.1002/anie.202424871}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424871}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Why mental health literacy can improve STEM}, volume = {64}, year = {2025}, }
• (2025). Identifying key properties that drive redox mediator activity in lactiplantibacillus plantarum. ANGEW, 64(19), e202424867. (www)

  @article{ , abstract = {Lactiplantibacillus plantarum is known to utilize exogenous small molecule quinone mediators to perform extracellular electron transfer (EET), allowing it to produce a detectable current in a bioelectrochemical system (BES). Utilization of quinone mediators by L. plantarum requires a type-II NADH dehydrogenase (Ndh2); however, structural variations in the core of 1,4-naphthoquinone EET mediators have shown to yield significantly different current outputs. Herein, we assembled a library of 40 quinone-based EET mediators to probe the important physicochemical properties and biochemical interactions responsible for Ndh2-dependent EET in L. plantarum . The library was designed with inspiration from naturally occurring metabolites, and assembly was focused on structural modifications that diversified polarity, reduction potential, and predicted free energy of binding to Ndh2 (ΔG comp ), as these properties are hypothesized to drive EET activity. In general, Ndh2-dependent EET activity in an iron(III) nanoparticle reduction assay significantly correlates to the mediator's polarity and ΔG comp . Five mediators were analyzed in BESs with L. plantarum , and each generated Ndh2-dependent current over background signal. Importantly, an amine-containing mediator yielded incredibly stable current output over the course of the experiment (up to 5 days). These findings improve our understanding of structure-activity relationships for quinone-mediated EET and provide stable mediators for bioelectronic sensing applications.}, archive = {J_ANGEW}, author = {Benjamin T. Blackburn and Robyn A. C. Alba and Vladimir O. Porokhin and Rong Cai and Arden Hatch and Soha Hassoun and Caroline M. Ajo-Franklin and Emily Mevers}, doi = {10.1002/anie.202424867}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424867}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identifying key properties that drive redox mediator activity in lactiplantibacillus plantarum}, volume = {64}, year = {2025}, }
• (2025). In-cell fast photochemical oxidation interrogates the native structure of integral membrane proteins. ANGEW, 64(19), e202424779. (www)

  @article{ , abstract = {Integral membrane proteins (IMPs) are pivotal for cellular functions but challenging to investigate. Here, IC-FPOMP (in-cell fast photochemical oxidation of MPs) is introduced, a method enabling in situ footprinting of IMPs within live cells. IC-FPOMP generates reactive oxygen radicals from various precursors (TiO 2 nanoparticles or H 2 O 2 ) near the membrane. Leveraging a laser and a 96-well plate platform, high-throughput and rapid footprinting of IMPs are achieved. IC-FPOMP of two human IMPs (human glucose transporter-hGLUT1 and human gamma-glutamyl carboxylase-hGGCX) are successful, providing footprinting of both the transmembrane and extramembrane regions. Comparative analysis of hGLUT1 in liposomes versus cells shows that the membrane may impact the transporter‘s conformation differently. In-cell drug screening targeting hGLUT1 reveals drug-binding behavior in vivo. In summary, IC-FPOMP offers insights into IMP structure-function relationships in cells and facilitates drug discovery.}, archive = {J_ANGEW}, author = {Jie Sun and Mierxiati Saimi and Don Rempel and Qing Cao and Mengqi Chai and Weikai Li and Michael L. Gross}, doi = {10.1002/anie.202424779}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424779}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-cell fast photochemical oxidation interrogates the native structure of integral membrane proteins}, volume = {64}, year = {2025}, }
• (2025). Electronic excitation and high-energy reactions originate from anionic microdroplets formed by electrospray or pneumatic nebulization. ANGEW, 64(19), e202424662. (www)

  @article{ , abstract = {Formation of energetic species at the surface of aqueous microdroplets, including abundant hydroxyl radicals, oxidation products, and ionized N 2 and O 2 gas, has been previously attributed to the high electric field at the droplet surface. Here, evidence for a new mechanism for electronic excitation involving electron emission from negatively charged water droplets is shown. Droplet evaporation can lead to the emission of ions and droplet fission, but unlike positively charged droplets, negatively charged droplets can also shed charge by electron emission. With nanoelectrospray, no anions or negatively charged droplets are produced with a positive electrospray potential. In contrast, abundant O 2 +• and H 3 O + (H 2 O) are formed with negative electrospray. When toluene vapor is introduced with negative electrospray, abundant toluene radical cations and fragments are produced. Both O 2 +• and toluene radical cations are produced with pneumatic nebulization. The electrons produced from evaporating negatively charged droplets can be accelerated by an external electric field in electrospray, or by the field generated between droplets with opposite polarities produced by pneumatic nebulization. This electron emission/ionization mechanism leads to electronic excitation >10 eV, and it may explain some of the surprising chemistries that were previously attributed to the high intrinsic electric field at the surface of aqueous droplets.}, archive = {J_ANGEW}, author = {Casey J. Chen and Veena S. Avadhani and Evan R. Williams}, doi = {10.1002/anie.202424662}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424662}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic excitation and high-energy reactions originate from anionic microdroplets formed by electrospray or pneumatic nebulization}, volume = {64}, year = {2025}, }
• (2025). Multi-shelled hollow covalent organic framework nanospheres for stable potassium storage. ANGEW, 64(19), e202424641. (www)

  @article{ , abstract = {Multi-shelled hollow covalent organic framework nanospheres (MH-COFs) with at least two shells integrate the merits of the porous crystalline covalent organic framework (COF) matrix with the complex hollow architecture, which can motivate new functions for exceptional performance. However, the fabrication of MH-COFs is still uncultivated and remains a formidable challenge. Herein, we reported a facile template-free protocol for the general synthesis of different MH-COFs by controlling the simultaneous processes of surface crystallization and core etching of the crystalline-inhomogeneity nanospheres of COFs precursor. The crystalline-inhomogeneity solid covalent organic polymer nanospheres (COPs) with robust crystalline surface but vulnerable amorphous core were designed. Subsequently, an acetic acid aqueous solution treatment of crystalline-inhomogeneity COPs not only induced selective etching of the vulnerable cores but also promote the further crystallization of the surface layers, thereby producing hollow COFs. A further step-by-step expansion of seeded growth for inhomogeneous COP layers and then similar acid solution treatment can output the intriguing MH-COFs. An extraordinarily stable K-ion battery anode with high capacity was demonstrated with a MH-COFs/S nanocomposite fabricated by covalently bonding chain sulfur into the MH-COFs matrix. This work opened a simple but powerful avenue in designing complex hollow COFs architectures to boost their potential for applications.}, archive = {J_ANGEW}, author = {Yan-Fei Chen and Ying Fang and Ning-Ning Zhu and Xiao Luo and Guo-Yu Zhu and Menghua Yang and Run-Hang Chen and Xian Zeng and Ji-Miao Xiao and Lin Liu and Guo-Hong Ning and De-Shan Bin and Dan Li}, doi = {10.1002/anie.202424641}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-shelled hollow covalent organic framework nanospheres for stable potassium storage}, volume = {64}, year = {2025}, }
• (2025). Compensating k ions through an organic salt in electrolytes for practical K-ion batteries. ANGEW, 64(19), e202424516. (www)

  @article{ , abstract = {K-ion batteries face significant challenges due to a severe shortage of active K ions, with cathode materials typically containing less than 70% K ions and first-cycle irreversible reactions consuming up to 20% more. Conventional K-ion compensation methods fail to supply sufficient K ions without compromising cell integrity. To address this, we introduce potassium sulfocyanate (KSCN) as an electrolyte additive capable of delivering up to 100% active K ions. During initial charging, KSCN undergoes oxidative decomposition at 3.6 V, releasing active K ions and forming the cosolvent thiocyanogen ((SCN) 2 ). This molecule, meeting diverse electrochemical properties, was identified using unsupervised machine learning and cheminformatics. The approach demonstrated full KSCN conversion and excellent compatibility with all cell components. The presence of (SCN) 2 cosolvent enhanced the rate capability of anodes by promoting K-ion desolvation. In a hard carbon|K 0.5 Mg 0.15 [Mn 0.8 Mg 0.05 ]O 2 pouch cell, this approach tripled the capacity through supplying 58% active K ions, showcasing a practical solution for active K-ion compensation in K-ion batteries.}, archive = {J_ANGEW}, author = {Wenwen Wang and Guanbin Wu and Pai Wang and Shu Chen and Ruijie Luo and Huajing Li and Yongning Zhou and Zulipiya Shadike and Yue Gao}, doi = {10.1002/anie.202424516}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Compensating k ions through an organic salt in electrolytes for practical K-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Prediction and validation of mechanical flexibility in molecular crystals: Dispersion interactions dictate bending. ANGEW, 64(19), e202424496. (www)

  @article{ , abstract = {Mechanically flexible crystals are a rapidly growing class of functional molecular materials. Typically, such flexible crystals are discovered by serendipity. Herein, we have predicted mechanical flexibility in a series of molecular crystals based on a structure screening approach that combines interaction topology and the presence of nitrile···nitrile interactions—a supramolecular motif hitherto not associated with bending property. Further, we have experimentally validated plastic/elastic bending properties in a series of crystal structures thus predicted. However, four out of five of these crystals showed the bending direction along π···π stacking despite the fact that the direction of strongest interaction anisotropy was rendered by the nitrile···nitrile interaction motifs. This is contrary to the commonly perceived anisotropy model and underscores the dominant role of dispersion forces over the electrostatically stabilized motifs in dictating the bending phenomena in molecular crystals. The interaction energies of these motifs have been evaluated using accurate structures from X-ray quantum crystallography. Analyses combining elastic tensors, interaction anisotropy indices, thermal expansion studies, and high-pressure simulations quantify the relative roles of the nitrile···nitrile motif and π···π stacking in mechanical flexibility. Our results point to the possibility of expanding the realm of flexible molecular materials to novel structural types aided by predictive computational models.}, archive = {J_ANGEW}, author = {Ashi Singh and Atiqur Rahman and Srijan Mondal and Mark A. Spackman and Bo B. Iversen and Sajesh P. Thomas}, doi = {10.1002/anie.202424496}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Prediction and validation of mechanical flexibility in molecular crystals: Dispersion interactions dictate bending}, volume = {64}, year = {2025}, }
• (2025). Site-selective C─H bond functionalization of sugars. ANGEW, 64(19), e202424455. (www)

  @article{ , abstract = {Non-typical C-functionalized sugars represent a prominent yet hardly accessible class of biologically-active compounds. The available synthetic methodologies toward such sugar derivatives suffer either from an extensive use of protecting groups, requiring long and laborious synthetic manipulations, or from limited predictability and noncontrollable site-selectivity of the employed C-functionalization reactions. In this work, we disclose an alternative synthetic methodology toward nontypical sugars that allows facile, site-selective, and stereocontrolled C-functionalization of sugars through a traceless tethering approach. The described silyl-based redox-active tethering group appends directly to the unprotected sugar substrate and mediates the C-functionalization reaction through a photochemically-promoted 1,6-hydrogen atom transfer (HAT) mechanism, while transforming into a readily-removable silyl protecting group. The protocol is compatible with a variety of unprotected carbohydrate substrates featuring sensitive aglycons and a diverse set of coupling partners, providing a straightforward and scalable route to pharmaceutically relevant C-functionalized carbohydrate conjugates.}, archive = {J_ANGEW}, author = {Elena V. Stepanova and Andrey Shatskiy and Ivan Doroshenko and Peter Dinér and Markus D. Kärkäs}, doi = {10.1002/anie.202424455}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424455}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-selective C─H bond functionalization of sugars}, volume = {64}, year = {2025}, }
• (2025). Highly ordered polymorphism of small molecule acceptor delivering efficient and stable binary organic solar cells. ANGEW, 64(19), e202424430. (www)

  @article{ , abstract = {Advancements in narrow bandgap organic small molecule acceptors (SMAs) has promoted organic solar cell (OSC) efficiencies beyond 20%. Achieving this milestone necessitates precise control over the active layer morphology, particularly its crystallinity and phase distribution, to optimize light absorption, charge transport, and suppress charge recombination. However, controlling SMA morphology remains a significant challenge due to their strong aggregation tendency. Existing methods, including high-temperature annealing, and introducing high boiling point additives, frequently yield disordered polymorphs with limited scalability. Here, we report a novel approach of utilizing 4-bromochlorobenzene as a volatile solid additive to induce the formation of a highly ordered polymorph of BTP-eC9 through mild annealing at 60 °C. This marks the first demonstration of such an ordered SMA polymorph, exhibiting optical properties comparable to ideal crystals, including enhanced anisotropy, refractive index, and extinction coefficients. The specific polymorph further enables the formation of a well-organized PM6 donor arrangement, establishing an optimal bicontinuous network morphology. Consequently, the OSCs based on PM6:BTP-eC9 achieve a power conversion efficiency of 19.53%, which further increases to 20.32% with the addition of an antireflection layer. This work provides a scalable and effective strategy for enhancing OSC performance and highlights the critical role of polymorphism in optimizing photovoltaic performance.}, archive = {J_ANGEW}, author = {Panpan Zhang and Ni Gao and Bo Du and Zhigang Xu and Shangrong Wu and Keteng Zhu and Xiao Ma and Haijun Bin and Yongfang Li}, doi = {10.1002/anie.202424430}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424430}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly ordered polymorphism of small molecule acceptor delivering efficient and stable binary organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Ionic liquid-mediated oxidative degradation of polycaprolactone into adipic acids over Pt/TiO2 in water. ANGEW, 64(19), e202424236. (www)

  @article{ , abstract = {Upgrading polyester waste into high value-added chemicals can achieve carbon recycling, which is of great significance for sustainable development. Herein, we report a one-pot protocol to oxidatively degrade polycaprolactone (PCL) with air into adipic acid (AA) mediated by ionic liquid (IL, e.g., 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, [BMIm][NTf 2 ]) in water. In this protocol, IL catalyzes the hydrolysis of PCL into 6-hydroxyhexanoic acid (6-HHA) and further mediates the oxidation of 6-HHA into AA over TiO 2 -supported Pt nanocatalysts, reaching the highest AA yield of 85.6% under relatively mild conditions (140 °C, 1.5 MPa). Mechanism investigation indicates that both O 2 •– and •OH derived from oxygen and water are involved in the oxidation of 6-HHA to form 6-oxohexanoic acid via two pathways, which further convert into AA. The IL inhibits the overoxidation of AA, thus leading to a high selectivity toward AA. This protocol provides a green and feasible way to degrade PCL and also to access AA.}, archive = {J_ANGEW}, author = {Yusi Wang and Hui Zhang and Wei Zeng and Yanfei Zhao and Rongxiang Li and Minhao Tang and Buxing Han and Zhimin Liu}, doi = {10.1002/anie.202424236}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424236}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ionic liquid-mediated oxidative degradation of polycaprolactone into adipic acids over Pt/TiO2 in water}, volume = {64}, year = {2025}, }
• (2025). Photo-RAFT polymerization under microwatt irradiation via unimolecular photoinduced electron transfer. ANGEW, 64(19), e202424225. (www)

  @article{ , abstract = {Photoinduced radical addition fragmentation chain transfer (PET-RAFT) polymerization typically requires high light intensity (>5 mW cm − 2 ), limiting energy efficiency, and scalability. We demonstrate that adding a base to PET-RAFT systems drastically enhances the reactivity of acidic chain transfer agents (CTAs) with Zn-based photocatalysts (Zn porphyrin and Zn phthalocyanine). This approach enables complete polymerization under microwatt light intensity (0.25 mW cm − 2 ), a significant improvement over traditional PET-RAFT, which showed no conversion under the same conditions. Both acrylates and methacrylates polymerized efficiently with excellent chain-end fidelity. Reactivity was triggered chemically (via base addition) or electrochemically (via electrolytic reduction). Mechanistic studies reveal that base addition promotes a CTA-Zn photocatalyst complex, shifting the activation from bimolecular to more efficient unimolecular PET-RAFT.}, archive = {J_ANGEW}, author = {Giovanni Lissandrini and Davide Zeppilli and Francesca Lorandi and Krzysztof Matyjaszewski and Abdirisak A. Isse and Laura Orian and Marco Fantin}, doi = {10.1002/anie.202424225}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424225}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-RAFT polymerization under microwatt irradiation via unimolecular photoinduced electron transfer}, volume = {64}, year = {2025}, }
• (2025). Mechanochemically enabled formal reductive cross-coupling reaction between aryl ethers and aryl fluorides. ANGEW, 64(19), e202424186. (www)

  @article{ , abstract = {Reductive cross-coupling reactions involving two electrophilic reagents have become increasingly important in modern synthetic chemistry. Previous studies have investigated electrophilic reagents featuring zero or one inactive bond; however, reactions involving electrophilic reagents with two inactive bonds remain unexplored. This study presents the first nickel-catalyzed reductive cross-coupling reaction under mechanical conditions, involving aryl ethers and aryl fluorides, both of which contain inactive bonds. The reaction successfully synthesized a series of multifunctional biphenyl compounds, specifically including several sparingly soluble substrates that are challenging to prepare in a solvent system. Mechanistic studies have demonstrated that nickel and magnesium play a crucial role in the activation of C─F bonds. This novel coupling reaction offers a beneficial approach for polymer degradation and the development of luminescent materials.}, archive = {J_ANGEW}, author = {Tianfen Liu and Xuemei Zhang and Qingqing Wang and Zhong Lian}, doi = {10.1002/anie.202424186}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202424186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanochemically enabled formal reductive cross-coupling reaction between aryl ethers and aryl fluorides}, volume = {64}, year = {2025}, }
• (2025). A highly crystalline covalent organic framework with rich redox active sites as cathode material for lithium batteries. ANGEW, 64(19), e202423992. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have been regarded as promising cathode materials for lithium batteries. However, they generally show low practical capacity. Here, the design, preparation, and battery application of a highly crystalline 2D truxenone-based COF (TRO-BT-COF) with rich redox active sites, realizing a high practical capacity is reported. In situ characterizations and theoretical calculations indicate that the lithiation reaction proceeds successively on C═O and C═N groups of TRO-BT-COF. One ring of TRO-BT-COF can theoretically store 27 Li + ions through two stages. Consequently, the highly crystalline TRO-BT-COF displays a high discharge capacity of 435 mAh g −1 when used as a cathode material for lithium batteries. This work provides a facile approach to achieve COF electrode materials with high practical capacity for lithium batteries.}, archive = {J_ANGEW}, author = {Can Wang and Youxuan Ni and Chunyan Zhu and Yixin Li and Zhenhua Yan and Yong Lu and Jun Chen}, doi = {10.1002/anie.202423992}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423992}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly crystalline covalent organic framework with rich redox active sites as cathode material for lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Trap-enabled long exciton lifetime in low-toxicity quantum dots for enhanced photochemistry. ANGEW, 64(19), e202423960. (www)

  @article{ , abstract = {Prolonging exciton lifetime in colloidal quantum dots (QDs) is crucial to their photochemical applications. Previously, this was achieved through a mechanism called thermally activated delayed photoluminescence (TADPL) for QDs surface-anchored with molecular triplet energy acceptors, in which the molecular triplets sensitized by QDs can repopulate QD-excitons through thermally activated reverse energy transfer. Here, we demonstrate a novel TADPL mechanism achieved by engineering the surface trap states of QDs. Rapid exciton trapping and thermally activated slow detrapping prolong the exciton lifetime of low-toxicity ZnSe-based QDs from the timescale of ∼10 ns to ∼100 µs. Such a long exciton lifetime allows direct engagement of QDs in diffusion-assisted energy transfer, without needing surface-anchored molecules as triplet transmitters, for solution-phase photochemical applications such as photon upconversion and [2 + 2] cycloaddition. This advantage not only greatly streamlines the design of QD-based photochemical systems but also avoids the reliability issue associated with the anchoring between QDs and molecules, as well as enabling facile tuning of the TADPL wavelength range not limited by the availability of molecular triplet acceptors.}, archive = {J_ANGEW}, author = {Shan He and Lei Wang and Xin Zhang and Yongshun Lv and Zixiang Zhou and Rongxin Zhang and Ying Liang and Guijie Liang and Jun Du and Kaifeng Wu}, doi = {10.1002/anie.202423960}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423960}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Trap-enabled long exciton lifetime in low-toxicity quantum dots for enhanced photochemistry}, volume = {64}, year = {2025}, }
• (2025). Explainable synthesizability prediction of inorganic crystal polymorphs using large language models. ANGEW, 64(19), e202423950. (www)

  @article{ , abstract = {We evaluate the ability of machine learning to predict whether a hypothetical crystal structure can be synthesized and explain those predictions to scientists. Fine-tuned large language models (LLMs) trained on a human-readable text description of the target crystal structure perform comparably to previous bespoke convolutional graph neural network methods, but better prediction quality can be achieved by training a positive-unlabeled learning model on a text-embedding representation of the structure. An LLM-based workflow can then be used to generate human-readable explanations for the types of factors governing synthesizability, extract the underlying physical rules, and assess the veracity of those rules. These explanations can guide chemists in modifying or optimizing non-synthesizable hypothetical structures to make them more feasible for materials design.}, archive = {J_ANGEW}, author = {Seongmin Kim and Joshua Schrier and Yousung Jung}, doi = {10.1002/anie.202423950}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423950}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Explainable synthesizability prediction of inorganic crystal polymorphs using large language models}, volume = {64}, year = {2025}, }
• (2025). Molybdenum-catalyzed ammonia synthesis by using zero-valent metal powder with alcohols or water. ANGEW, 64(19), e202423858. (www)

  @article{ , abstract = {We have recently achieved a highly effective ammonia formation from dinitrogen using samarium diiodide and water under ambient reaction conditions. However, further research is needed to establish a carbon-free green ammonia production route without carbon dioxide emissions. In this study, we have developed a novel molybdenum-catalyzed nitrogen fixation method using a combination of zero-valent metal powders as reductants and alcohols or H 2 O as a proton source under ambient reaction conditions. In this reaction system, samarium compounds serve as crucial electron mediators for the molybdenum complexes. Remarkably, the combination of zinc powder and water in the presence of samarium triiodide facilitates highly selective ammonia production over dihydrogen under ambient reaction conditions, yielding up to 900 equiv of ammonia per Mo atom in the catalyst. Intriguingly, using magnesium powder, known for its potent reducing capability, reduces the requisite amount of samarium compounds to catalytic levels. We believe that the novel insights gained from this reaction system represent a substantial step toward achieving green ammonia production.}, archive = {J_ANGEW}, author = {Taichi Mitsumoto and Yoshiaki Nishibayashi}, doi = {10.1002/anie.202423858}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423858}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molybdenum-catalyzed ammonia synthesis by using zero-valent metal powder with alcohols or water}, volume = {64}, year = {2025}, }
• (2025). Elucidating relay catalysis on copper clusters with satellite single atoms for enhanced urea electrosynthesis. ANGEW, 64(19), e202423706. (www)

  @article{ , abstract = {Relay catalysis represents significant efficacy in alleviating competition among different reactants during coupling reactions. However, a comprehensive understanding of the reaction mechanism underlying relay catalysis for the urea electrosynthesis remains challenging. Herein, we have developed a catalyst (Cu AC -Cu SA @NC) comprising Cu atomic clusters (Cu AC ) with satellite Cu─N 4 single atoms (Cu SA ) sites on the nitrogen-doped porous interconnected carbon skeleton (NC), enabling elucidation of a relay catalysis process for co-reduction of CO 2 and NO 3 − . The designed Cu AC -Cu SA @NC catalyst exhibits an approximately threefold higher urea yield rate compared to that of Cu SA @NC at −1.3 V versus RHE. Ex-situ experimental results and in-situ attenuated total reflection surface-enhanced infrared absorption spectroscopy analysis reveal a formation sequence between the *NH 2 and *NH 2 CO species on Cu AC -Cu SA @NC with increasing reduction potential. The combination of theoretical calculations further elucidates that the relay catalysis pathway involves “Cu AC ” sites facilitating the conversion of *NO 3 to *NO x , followed by a hydrogenation process to form *NH 2 with *H from water dissociation promoted by “Cu SA ” sites, which subsequently couples with *CO 2 to produce urea. This work provides novel insights into the investigation of coupling reactions, but not limit to, urea synthesis.}, archive = {J_ANGEW}, author = {Xinyue Ma and Baoguang Mao and Zeqiang Yu and Dan Wang and Jing Xia and Jianhua Hou and Xiangmin Meng and Husitu Lin and Chuangang Hu}, doi = {10.1002/anie.202423706}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423706}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elucidating relay catalysis on copper clusters with satellite single atoms for enhanced urea electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Formation and metallomimetic reactivity of a transient dicoordinate alkylborylene. ANGEW, 64(19), e202423669. (www)

  @article{ , abstract = {While existing literature has primarily focused on carbene-stabilized amino- and arylborylenes of the form [(carbene)BR] (R = substituent), herein we report the generation and metallomimetic reactivity of the first carbene-stabilized alkylborylene [(CAAC Me )BCy] (CAAC Me = 1-(2,6-di iso propylphenyl)-3,3,5,5-tetramethylpyrrolidin-2-ylidene, Cy = cyclohexyl). Furthermore, the transition metal-like decarbonylation reactions of a borylene complex, [(CAAC Me )BCy(CO)], derived from borylene [(CAAC Me )BCy] and CO, are described. Additional findings described include i) the identification of the coordination stages of the ligand to boron towards forming complexes [(CAAC Me )BCyL] in the reduction route from starting material [(CAAC Me )BCyBr 2 ] and in the photolysis route from carbonyl complex [(CAAC Me )BCy(CO], and ii) insights from quantum-chemical computations regarding the molecular and electronic structure of the borylene at various stages.}, archive = {J_ANGEW}, author = {Yannick Konrad and Arumugam Jayaraman and Ivo Krummenacher and Holger Braunschweig}, doi = {10.1002/anie.202423669}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formation and metallomimetic reactivity of a transient dicoordinate alkylborylene}, volume = {64}, year = {2025}, }
• (2025). Chlorinated bithiophene imide-based n-type polymers: Synthesis, Structure–Property correlations, and applications in organic electronic devices. ANGEW, 64(19), e202423616. (www)

  @article{ , abstract = {Developing electron-deficient (hetero)arenes with optimized geometries and electronic properties is imperative for advancing n -type polymers and organic electronic devices. We report here the design and synthesis of two chlorinated imide-functionalized electron-deficient heteroarenes, namely chlorine-substituted bithiophene imide (ClBTI) and its fused dimer (ClBTI2). The corresponding polymers show a near-planar framework, appropriate frontier molecular orbital levels, and good solubility. When integrated into organic thin-film transistors, ClBTI2-based n-type polymer afforded unipolar electron mobility of up to 0.48 cm 2 V −1 s −1 . The binary all-PSCs based on PM6 and new polymers show a power conversion efficiency (PCE) exceeding 1%. Interestingly, by introducing these polymers with ordered structure, high crystallinity, and sizable electron mobility as the third component into the host system PM6:PY-IT, continuous interpenetrating networks with large fibrillar structures can be formed. Investigations of charge transfer kinetics and energy loss analyses unveiled that ClBTI2-based n-type polymer P(ClBTI2-BTI) enables optimized charge transport, reduced charge recombination, and minimized non-radiative loss within the all-polymer ternary blends, yielding a remarkable PCE of 19.35% (certified: 19.20%) through optimizing the state-of-the-art PM6:PY-IT blend. The structure–property–performance relationships provide valuable insights into the design of electron-deficient (hetero)arenes and n-type polymers, marking a great progress in the development of high-performance n-type polymers for organic electronic devices.}, archive = {J_ANGEW}, author = {Suxiang Ma and Henan Li and Wenchang Wu and Sergio Gámez-Valenzuela and Ruijie Ma and Qingqing Bai and Jianbin Zhong and Sang Young Jeong and Qian Liu and Hao Zhang and Guangye Zhang and Wei Zhang and Junwu Chen and Enmin Huang and Bin Liu and Kui Feng and Han Young Woo and Li Niu and Huiliang Sun and Xugang Guo}, doi = {10.1002/anie.202423616}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chlorinated bithiophene imide-based n-type polymers: Synthesis, Structure–Property correlations, and applications in organic electronic devices}, volume = {64}, year = {2025}, }
• (2025). Targeted degradation of ZBP1 with covalent PROTACs for anti-inflammatory treatment of infections. ANGEW, 64(19), e202423524. (www)

  @article{ , abstract = {Z-DNA binding protein 1 (ZBP1) has emerged as a critical pathogen-sensing protein that upon activation, triggers necroptotic signaling cascades, leading to a potent inflammatory response and potentially causing significant tissue damage. However, available drugs specifically developed for the effective inhibition or degradation of ZBP1 is still lacking so far. In this study, we developed a potent covalent recognition-based PROTAC (C-PROTAC) molecule for the degradation of ZBP1. It consists of a DNA aptamer as the recognition moiety and an E3 enzyme-recruiting unit, connected by a linker containing N -acyl- N -alkyl sulfonamides (NASA) groups. The DNA aptamer specifically binds to ZBP1, while the NASA-containing linker facilitates the formation of a covalent bond between the PROTAC and the target protein. The E3 ligase-recruiting unit then directs the ubiquitin-proteasome system to degrade the ZBP1-PROTAC complex. This approach combines the high specificity of DNA aptamers with the efficiency of covalent binding and the degradation-inducing capabilities of PROTACs, providing a powerful tool for targeted protein degradation. The successful application of this technology to ZBP1 highlights its potential for the selective elimination of disease-associated proteins and the development of novel therapeutic strategies.}, archive = {J_ANGEW}, author = {Rentang Huang and Yusi Hu and Yi-Fan Wang and Shiyu Zhang and Zhi-Gang Wang and Dai-Wen Pang and Shu-Lin Liu}, doi = {10.1002/anie.202423524}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Targeted degradation of ZBP1 with covalent PROTACs for anti-inflammatory treatment of infections}, volume = {64}, year = {2025}, }
• (2025). Singlet-oxygen-driven cooperative photocatalytic coupling of biomass valorization and hydrogen peroxide production using covalent organic frameworks. ANGEW, 64(19), e202423368. (www)

  @article{ , abstract = {Traditional H 2 O 2 photocatalysis primarily depends on photoexcited electrons and holes to drive oxygen reduction and water oxidation, respectively. However, singlet oxygen ( 1 O 2 ), often underappreciated, plays a pivotal role in H 2 O 2 production. Meanwhile, photocatalytic biomass conversion has attracted attention, yet studies combining H 2 O 2 synthesis with biomass valorization remain rare and typically yield low-value products. Herein, a strategy of photocatalytic valorization of furfuryl alcohol (FFA) coupled with the efficient co-production of H 2 O 2 is reported, enabled by covalent organic frameworks (COFs) induced, 1 O 2 -participated Achmatowicz rearrangement. This study introduces polyimide-based COF-N 0-3 with tailored nitrogen content, representing an unprecedently efficient platform for 1 O 2 production. Remarkably, reducing the nitrogen content of the COF enhances 1 O 2 production, significantly boosting the H 2 O 2 generation rate. In FFA, the primary pathway for H 2 O 2 production is Achmatowicz rearrangement, achieving a rate ten times higher than that reliant on oxygen reduction reaction in pure water, reaching 4549 µmol g⁻¹ h⁻¹. Mechanism studies revealed 1 O 2 selectively engaged FFA, bypassing hole oxidation to trigger the Achmatowicz rearrangement, producing valuable 6-hydroxy-(2H)-pyranone with 99% conversion and 92% selectivity. This work establishes a coupling strategy for simultaneous synthesis of H 2 O 2 and biochemicals, offering a transformative approach to sustainable photocatalysis.}, archive = {J_ANGEW}, author = {Qiang Xue and Hanxi Li and Peng Jin and Xukai Zhou and Feng Wang}, doi = {10.1002/anie.202423368}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423368}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Singlet-oxygen-driven cooperative photocatalytic coupling of biomass valorization and hydrogen peroxide production using covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Photoisomerization of azobenzene-extended charybdotoxin for the optical control of kv1.2 potassium channel activity. ANGEW, 64(19), e202423278. (www)

  @article{ , abstract = {Natural peptides from animal venoms effectively modulate ion channel activity. While photoswitches regulate small compound pharmacology, their application to natural peptides rich in disulfide bridges and active on ion channels is novel due to larger pharmacophores. A pilot study integrating azobenzene photoswitches into charybdotoxin (ChTx), known for blocking potassium channels is initiated. Two click-chemistry-compatible azobenzene are synthesized differing in length and amide orientation (Az 1 & Az 2 ). Az 1 is grafted onto ChTx at various amino acid positions using L-azidohomoalanine mutation. ChTx monomers outperformed dimers, particularly with azobenzene at position 14, by exhibiting optimal photoswitching activity. In the cis configuration, Az 1 altered ChTx's pharmacophore, reducing potassium channel blockage, while conversely, Az 2 increased ChTx potency. This study pioneers photoswitch application to complex peptides, leveraging structure-activity relationships. Successful integration depends on precise azobenzene positioning and chemical grafting guided by SAR insights. This advancement underscores the adaptability of photoswitch technology to intricate peptide structures, offering new avenues for pharmacological modulation.}, archive = {J_ANGEW}, author = {Yanis Achouba and Basile Peres and Steven Ascoët and Hervé Meudal and Cécile Caumes and Claude Zoukimian and Hugo Millet and Maureen Choteau-Bodor and Cathy Carvalhosa and Mikael Croyal and Fella Bouchama and Heike Wulff and Stéphane Téletchéa and Rémy Béroud and Eléna Ishow and Céline Landon and Ahcène Boumendjel and Jérôme Montnach and Michel De Waard}, doi = {10.1002/anie.202423278}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423278}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoisomerization of azobenzene-extended charybdotoxin for the optical control of kv1.2 potassium channel activity}, volume = {64}, year = {2025}, }
• (2025). Establishing an efficient electron transfer system for p450 enzyme OleP to improve the biosynthesis of murideoxycholic acid by redox partner engineering. ANGEW, 64(19), e202423209. (www)

  @article{ , abstract = {The electron transfer from NAD(P)H to heme is a rate-limiting step in the redox partner-mediated catalysis of P450 enzyme. However, due to the lack of efficient engineering strategies, it is difficult to improve the properties of redox partner. Herein, we construct an effective approach to modify the redox partner for a typical P450 enzyme (OleP) that can catalyze the stereoselective conversion of lithocholic acid to murideoxycholic acid. First, the combination of computational modeling and experimental validation was performed to rapidly identify the most suitable redox partner (PetH/PetF). Next, the interactions between PetF and OleP were investigated and the engineering on PetF was conducted to enhance the efficiency of electron transfer. Using a novel microplate screening method, a superior mutant (PetF F64D ) was efficiently selected, which exhibited a significant enhancement in MDCA conversion yield from 32.5% to 80.9% and total turnover number (TTN) from 406.2 to 1617.9. Finally, through a combination of molecular dynamics simulations, the analysis of electron transfer pathway, and the calculations of electron transfer rate, the mechanism of electron transfer was investigated. The applied engineering strategies, high-throughput screening methods, and analytical approaches provide a feasible way to construct an ideal redox partner for other P450 enzymes.}, archive = {J_ANGEW}, author = {Chixiang Sun and Yongchao Wang and Baodong Hu and Jianan Wang and Jingwen Zhou and Jianghua Li and Jian Chen and Guocheng Du and Binju Wang and Xinrui Zhao}, doi = {10.1002/anie.202423209}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423209}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Establishing an efficient electron transfer system for p450 enzyme OleP to improve the biosynthesis of murideoxycholic acid by redox partner engineering}, volume = {64}, year = {2025}, }
• (2025). A general and mild two-step strategy using bioderived diols and CO2 for chemically recyclable polycarbonates and closed-loop CO2 fixation. ANGEW, 64(19), e202423162. (www)

  @article{ , abstract = {Developing chemically recyclable polymers using CO 2 and sustainable co-feedstocks is an important strategy for achieving carbon-neutral production of new polymers and mitigating plastic pollution. Herein, a series of six-membered cyclic carbonate monomers with different alkyl α -substituents were synthesized using CO 2 and bioderived 1,3-alkanediol as raw materials at room temperature and atmospheric pressure. The organocatalytic ring-opening polymerization was systematically studied using a range of common and readily available organocatalysts. Phosphazene base ( t -BuP 2 ) was identified as the most effective catalyst, offering excellent control over the entire polymerization. The regioselectivity of the synthesized polycarbonates, ranged from 0.74 to 0.99, with the highest value achieved when the side group was isopropyl (highest steric hindrance). Notably, the α -substituent in the monomers reduced the ring strains, allowing the resulting polycarbonates to be fully recycled to the monomers without decarboxylation. The recycling process effectively traps CO 2 in a closed loop between monomers and polymers, preventing its release into the atmosphere. The alkyl side groups enhanced the hydrophobicity of the polycarbonates, thereby reducing the likelihood of CO 2 release through hydrolysis during their lifecycle, achieving a robust CO 2 closed-loop fixation. The utility of CO 2 -based aliphatic polycarbonates as adhesives and the ability of copolymerization with l -lactide were explored.}, archive = {J_ANGEW}, author = {Jiaming Tian and Nikos Hadjichristidis and Xin Wang and Zhengbiao Zhang}, doi = {10.1002/anie.202423162}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202423162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A general and mild two-step strategy using bioderived diols and CO2 for chemically recyclable polycarbonates and closed-loop CO2 fixation}, volume = {64}, year = {2025}, }
• (2025). Isotope techniques in chemical wastewater treatment: Opportunities and uncertainties. ANGEW, 64(19), e202422892. (www)

  @article{ , abstract = {A comprehensive and in-depth analysis of reaction mechanisms is essential for advancing chemical water treatment technologies. However, due to the limitations of conventional experimental and analytical methods, the types of reactive species and their generation pathways are commonly debatable in many aqueous systems. As highly sensitive diagnostic tools, isotope techniques offer deeper insights with minimal interference from reaction conditions. Nevertheless, precise interpretations of isotope results remain a significant challenge. Herein, we first scrutinized the fundamentals of isotope chemistry and highlighted key changes induced by the isotope substitution. Next, we discussed the application of isotope techniques in kinetic isotope effects, presenting a roadmap for interpreting KIE in sophisticated systems. Furthermore, we summarized the applications of isotope techniques in elemental tracing to pinpoint reaction sites and identify dominant reactive species. Lastly, we propose future research directions, highlighting critical considerations for the rational design and interpretation of isotope experiments in environmental chemistry and related fields.}, archive = {J_ANGEW}, author = {Hongyu Zhou and Xiaoguang Duan and Bingkun Huang and Shuang Zhong and Cheng Cheng and Virender K. Sharma and Shaobin Wang and Bo Lai}, doi = {10.1002/anie.202422892}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422892}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isotope techniques in chemical wastewater treatment: Opportunities and uncertainties}, volume = {64}, year = {2025}, }
• (2025). Artificial carbon neutrality through aprotic CO2 splitting. ANGEW, 64(19), e202422888. (www)

  @article{ , abstract = {Global climate change mitigation necessitates global efforts to reduce CO 2 emissions. Natural photosynthesis exemplifies an ingenious approach to carbon neutrality, converting CO 2 into O 2 and glucose through light and dark reactions. Inspired by the hydrogen-involved processes in photosynthesis, an aprotic electrochemical strategy for CO 2 splitting into O 2 and carbon using lithium as a reducing mediator is presented. The designed electrochemical device features a gas cathode with a nanoscale Co catalyst and a metallic lithium anode. When CO 2 is introduced to the cathode, it undergoes a two-step lithium-related electrochemical reduction, converting it sequentially into Li 2 CO 3 and Li 2 O. Li 2 O is then oxidized to produce O 2 gas at the expense of renewable electrical energy. This process achieves an impressive O 2 yield exceeding 94.7%, significantly outperforming the efficiency of natural photosynthesis. Moreover, the O 2 yield can be further increased to 98.6% by employing an optimized RuCo catalyst. This study offers a new practical and controllable pathway to produce O 2 from CO 2 , strongly promoting the sustainable development of human society for realizing carbon neutrality as well as exploring and conquering nature.}, archive = {J_ANGEW}, author = {Wei Li and Xiaowei Mu and Sixie Yang and Di Wang and Yonggang Wang and Haoshen Zhou and Ping He}, doi = {10.1002/anie.202422888}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422888}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial carbon neutrality through aprotic CO2 splitting}, volume = {64}, year = {2025}, }
• (2025). Self-assembled monolayer of N-heterocyclic carbene as a primer in a dual-layer coating for corrosion protection on iron. ANGEW, 64(19), e202422879. (www)

  @article{ , abstract = {The development of highly stable coatings on iron is essential for mitigating corrosion formation. Herein, it is demonstrated that a self-assembled monolayer of N-Heterocyclic Carbene (NHC) can be electrodeposited on iron foil and function as a binder for a secondary, crosslinked polymer network coating. The dual layer coating, constructed of a monolayer of NHCs and a polymer film, as a primary and a secondary coating, respectively, effectively preventes corrosion formation with a protective efficiency of 99.6 ± 0.2 %, as determined by polarization measurements in 3.5 wt.% NaCl solution. Spectroscopic analysis identified the formation of a chemical interaction between the NHC monolayer and the polymer film. The strong anchoring of NHC to iron along with its chemical interaction with the polymer film induced high stability and durability of the dual-layer coating to effectively protect the coated iron from corrosion formation.}, archive = {J_ANGEW}, author = {Linoy Amar and Rajarshi Mondal and Omer Blumen and Lihi Rekanati and Iris Berg and Sara Harpaz and Daniel Sharon and Elad Gross}, doi = {10.1002/anie.202422879}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422879}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled monolayer of N-heterocyclic carbene as a primer in a dual-layer coating for corrosion protection on iron}, volume = {64}, year = {2025}, }
• (2025). NIR-sensitized activated formation of lophyl radicals by heptamethine cyanines enables dry film photoresists. ANGEW, 64(19), e202422700. (www)

  @article{ , abstract = {The near-infrared ( NIR ) sensitized generation of lophyl radicals ( L· ) by heptamethine cyanine led to initiation of radical photopolymerization of multifunctional acrylates when different hexa-arylbisimidazoles ( HABI s) and N -phenylglycine ( NPG ) operated as coinitiator. The latter functioned as donor. For a deeper understanding, heptamethine cyanines were used following a photoinduced electron transfer ( PET ). HABI derivatives with electron-donating and -withdrawing substituents demonstrated that those with electron acceptors resulted in a higher photopolymerization efficiency of multifunctional acrylates. Tri-(propylene glycol) diacrylate ( TPGDA ) and tri-methylolpropane triacrylate ( TMPTA ) served as the monomers. Sensitizers ( Sens ) exposed with a high intense NIR-light source at 808 nm exhibiting a positive charge in the cyanine pattern significantly operate more efficiently for radical photopolymerization than a Sens without a positive charge. Differences in efficiency of PET can give an explanation for these differences. The heat generated by the cyanine's internal conversion from S 1 to S 0 additionally influenced the endothermic reaction between L· and NPG . These systems worked in practical applications for dry film photoresists ( DFR s), reported here for the first time.}, archive = {J_ANGEW}, author = {Xianglong He and Yayu Shao and Weifeng Ma and Xun Sun and Zehao Jin and Yulian Pang and Yangyang Xin and Yingquan Zou and Bernd Strehmel}, doi = {10.1002/anie.202422700}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422700}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NIR-sensitized activated formation of lophyl radicals by heptamethine cyanines enables dry film photoresists}, volume = {64}, year = {2025}, }
• (2025). Kinetic redox shotgun proteomics reveals specific lipopolysaccharide effects on intestinal epithelial cells, mitigated by a mn superoxide dismutase mimic. ANGEW, 64(19), e202422644. (www)

  @article{ , abstract = {Overproduction of reactive oxygen species and antioxidant superoxide dismutases (SOD1, SOD2) dysregulation contribute to chronic inflammation such as generated in inflammatory bowel diseases (IBD). A kinetic redox shotgun proteomic strategy (OcSILAC for Oxidized cysteine Stable Isotope Labelling by Amino acids in Cell culture) was used to explore the lipopolysaccharide (LPS) effects including LPS-induced oxidation and inflammation cascades on a dedicated intestinal epithelial cell line (HT29-MD2) together with the potential mitigating role of a Mn-based SOD-mimic Mn1 . While LPS induced transient oxidative damages at early times (15 min), cells incubated with Mn1 showed, in this time frame, a significantly reduced cysteine oxidation, highlighting Mn1 antioxidant properties. Over time, cysteine oxidation of LPS-treated cells was counteracted by an overexpression of antioxidant proteins (SOD1, NQO1) and a late (6 h) preponderant increase in SOD2 level. Mn1 , when co-incubated with LPS, attenuated the level of most LPS-modified proteins, that is, proteins involved in the inflammatory response. Our results highlight Mn1 as a potentially effective antioxidant and anti-inflammatory agent to consider in the treatment of IBD, as well as a useful tool for exploring the interconnection between oxidative stress and inflammation.}, archive = {J_ANGEW}, author = {Martha Zoumpoulaki and Giovanni Chiappetta and Jean Bouvet and Namita-Raju John and Gabrielle Schanne and Pauline Gehan and Samuel Diebolt and Shakir Shakir and Elodie Quévrain and Emilie Mathieu and Sylvie Demignot and Philippe Seksik and Nicolas Delsuc and Joelle Vinh and Clotilde Policar}, doi = {10.1002/anie.202422644}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Kinetic redox shotgun proteomics reveals specific lipopolysaccharide effects on intestinal epithelial cells, mitigated by a mn superoxide dismutase mimic}, volume = {64}, year = {2025}, }
• (2025). Developing the tandem structure to regulate interfacial chemistry and promote ion transport kinetics toward high-voltage lithium metal batteries. ANGEW, 64(19), e202422539. (www)

  @article{ , abstract = {The chemical properties of the solid electrolyte interphase (SEI) layer and cathode electrolyte interphase (CEI) are crucial for achieving high-energy-density lithium metal batteries, especially under extreme operating conditions. Herein, we propose a delicately designed tandem separator (CYANO-COF|PP|SnF 2 ) to regulate the chemical stability of dual interfaces. The cyano group in CYANO-COF induces a stable CN-enriched CEI on the surface of high-nickel LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811) cathode through the adsorption/coordination effect with transition metals (TMs), inhibiting irreversible phase transitions, TMs dissolution, and other side reactions. Meanwhile, a straightforward in-situ conversion is used to construct an artificial hybrid SEI layer comprising LiF and Li–Sn alloy. As demonstrated theoretically and experimentally, the hybrid SEI with enhanced electron-blocking ability and rapid transmission characteristics can decrease the electron from the Li anode into the SEI and allow Li + to rapidly diffuse through the SEI layer, achieving even dendrite-free lithium plating at the SEI/Li interface. With the synergistic effect of dual interfaces, the NCM811||Li battery maintains a capacity retention of 81.8% within 200 cycles at 4.5 V and 55 °C. This work emphasizes the significance of regulating the chemical properties of double interfaces and provides new insights into the rational design for tandem separators.}, archive = {J_ANGEW}, author = {Qi An and Qing Liu and Panpan Mao and Lingyan Duan and Hai-ye Zhu and Lu Liu and Guiquan Zhao and Yunchun Zha and Li Yang and Mengjiao Sun and Yufeng Fan and Fanyu Xie and Guangzhi Hu and Hong Guo}, doi = {10.1002/anie.202422539}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422539}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Developing the tandem structure to regulate interfacial chemistry and promote ion transport kinetics toward high-voltage lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Full recovery of epoxy resin wastes into bisphenol a and epoxy monomers via lewis acid. ANGEW, 64(19), e202422472. (www)

  @article{ , abstract = {Epoxy resins (EPs) are important thermosetting plastics and difficult to recycle because of their stable cross-linked structure. In this study, we report a full recovery strategy for the conversion of EPs into high-value platform compounds, i.e., bisphenol A (BPA) and epoxy monomers such as 4,4′-methylenebis ( N , N ′-diglycidylaniline) (AG80), which involves the selective breaking of the C(sp 3 )─O bond using commercially available boron trichloride (BCl 3 ), the reconstruction of the broken C(sp 3 )─N bond and the cyclization of the hydroxy groups. The yield of BPA is 93 wt% with a purity of 99%, and the yield of AG80 is 96 wt% with an epoxy value of 0.43. 100% recovery of EP elements was achieved theoretically, and the actual mass recovery of the EPs is as high as 91%. Because of its versatility, simplicity of operation, mild reaction conditions, and recyclability of all solvents and by-products, this approach shows the potential in solving the current recycling challenges associated with EP waste.}, archive = {J_ANGEW}, author = {Xiaohui Li and Lulu Liu and Jing Yu and Xuehui Liu and Shimei Xu and Gang Wu and Yu-Zhong Wang}, doi = {10.1002/anie.202422472}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Full recovery of epoxy resin wastes into bisphenol a and epoxy monomers via lewis acid}, volume = {64}, year = {2025}, }
• (2025). Precise PBAEs: A highly efficient single-molecularly defined gene-delivery system. ANGEW, 64(19), e202422134. (www)

  @article{ , abstract = {Gene-delivery polymers have wide therapeutic applications. The structures (e.g., molecular weight, polymer sequence, end groups, and topology) of gene-delivery polymers are of crucial importance to their properties including transfection efficiency, toxicity, and targeting capability. Thus, precise control over the structures of gene-delivery polymers is extremely beneficial for property optimizations and manufacturing reproducibility. However, sequence-defined gene-delivery polymers with high efficiency and low toxicity are rare, limited by synthetic strategies. In this work, we developed a method that enables poly( β -amino esters), one of the most promising gene-delivery polymers, to be synthesized with precisely controlled and vastly variable molecular weight, end group, and topology. This synthetic strategy creates a new family of gene-delivery polymers with defined structures, offering significant potentials and revealing new design principles.}, archive = {J_ANGEW}, author = {Rong Ma and Yan Chang and Qimingxing Chen and Jianfeng Li and Bo Qiao}, doi = {10.1002/anie.202422134}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202422134}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise PBAEs: A highly efficient single-molecularly defined gene-delivery system}, volume = {64}, year = {2025}, }
• (2025). Universal albumin drugs-cored spherical nucleic acid (ad-SNA) platform for targeted drug delivery. ANGEW, 64(19), e202421949. (www)

  @article{ , abstract = {Albumin-based drug delivery system, exemplified by FDA-approved treatments like Abraxane, have demonstrated significant potential in cancer therapy. However, albumin carriers still suffer from poor tumor-targeting capability, leading to low efficacy and systemic side effects on healthy cells in applications. Here, we report a general method for modification of albumin drugs by aptamer coating shell that are hydrophobically inserted into the albumin surface, for constructing albumin drugs-cored spherical nucleic acid (adSNA). This adSNA platform allows for the versatile loading of various therapeutic agents, including chemotherapy drugs, polyphenols, cuproptosis inducers, and near-infrared (NIR) photosensitizers, enabling targeted tumor delivery. Compared with covalent method, the hydrophobic insertion method has been proven to be of greater simplicity, higher aptamer-grafting efficiency, superior tumor-targeting capabilities, and comparable stability under physiological conditions. In a proof-of-concept study, we delivered NIR-II photothermal agents and heat shock protein inhibitors for tumor-specific mild photothermal therapy. Compared to traditional photothermal therapy (PTT), this approach utilizes NIR-II PTT agents to achieve greater tissue penetration while downregulating heat shock proteins in tumor cells, resulting in precise thermal ablation at lower temperatures. In addition, the adSNAs are straightforward to synthesize and scalable for large-scale production, offering significant potential to advance the development of clinical targeted drugs.}, archive = {J_ANGEW}, author = {Xuan Wang and Linxin Tian and Yuqing Li and Wei Yao and Jiawei Zhu and Huayuan Zhou and Ganghui Chen and Tongkai Chen and Zhuang Liu and Weihong Tan and Yu Yang}, doi = {10.1002/anie.202421949}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202421949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Universal albumin drugs-cored spherical nucleic acid (ad-SNA) platform for targeted drug delivery}, volume = {64}, year = {2025}, }
• (2025). Ultrahigh molecular weight Ethylene–Acrylate copolymers synthesized with highly active neutral nickel catalysts. ANGEW, 64(19), e202421904. (www)

  @article{ , abstract = {Molecular weight is a crucial parameter in catalytic olefin polymerization to determine the thermomechanical properties of polymers. Elevating the molecular weight of ethylene–acrylate copolymer, a typical polar polyolefin has been a persistent challenge. This study presents the direct synthesis of ultrahigh molecular weight (UHMW) ethylene–acrylate copolymers using a highly active, neutral, single-component phosphine-phenolate nickel catalyst under mild conditions. The coordination-insertion copolymerization of ethylene and various acrylates, such as methyl acrylate, n -butyl acrylate, and t -butyl acrylate, can yield ethylene–acrylate copolymers with UHMWs ( M n ) ranging from 1000 to 2700 kDa, with exceptional activities of up to 4.03 × 10 6 g mol −1 h −1 . A relatively large-scale synthesis (30–50 g) of UHMW ethylene–acrylate copolymers was notably achieved. The properties of these UHMW ethylene–acrylate copolymers were comprehensively evaluated, demonstrating that these copolymers retained the bulk properties of ultrahigh molecular weight polyethylene (UHMWPE) while exhibiting improved surface and dyeing properties. In particular, the tensile strength of the ethylene–acrylate copolymers significantly increased with higher molecular weights, reaching 44 MPa (147 MPa after a predrawing ratio of 3.1), which is comparable to that of UHMWPE.}, archive = {J_ANGEW}, author = {Qingkun Yang and Xiaohui Kang and Yu Liu and Hongliang Mu and Zhongbao Jian}, doi = {10.1002/anie.202421904}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202421904}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrahigh molecular weight Ethylene–Acrylate copolymers synthesized with highly active neutral nickel catalysts}, volume = {64}, year = {2025}, }
• (2025). A magnetic field-assisted lithium-oxygen batteries with enhanced reaction kinetics by spin-polarization strategy. ANGEW, 64(19), e202421361. (www)

  @article{ , abstract = {Lithium–oxygen (Li–O 2 ) batteries have attracted significant attention due to their ultrahigh theoretical energy density, but are obstructed by the sluggish reaction kinetics at the cathode and high overpotential. Our previous researches have proved that energy fields such as light, force, and heat are effective strategies to improve the reaction kinetics of Li–O 2 batteries. Herein, we proposed a novel magnetic field-assisted Li–O 2 batteries via a spin polarization strategy. By doping magnetic Mn 2+ ions with spin polarization characteristics into CsPbBr 3 (Mn–CsPbBr 3 ) perovskite, a magnetic field-responsive cathode was designed and prepared. The incorporation of Mn 2+ ions drives the charge redistribution and spin polarization of CsPbBr 3 , which remarkably improve the carrier separation efficiency and the oxygen species adsorption energy. The Increased spin-polarization of the magnetic elements by Zeeman effect in an external magnetic field results in the enhanced oxygen reduction and evolution reaction. In the magnetic field, a low overpotential of 0.40 V was obtained for Li–O 2 batteries with Mn–CsPbBr 3 cathodes, demonstrating an ultralow overpotential of 0.12 V and an ultrahigh energy efficiency of 96.3% with the further illumination. The introduction of magnetic fields into the Li–O 2 battery system provides a new avenue for improving the reaction kinetics of rechargeable Li–O 2 battery.}, archive = {J_ANGEW}, author = {Xin-Yuan Yuan and De-Hui Guan and Xiao-Xue Wang and Jian-You Li and Cheng-Lin Miao and Ji-Jing Xu}, doi = {10.1002/anie.202421361}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202421361}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A magnetic field-assisted lithium-oxygen batteries with enhanced reaction kinetics by spin-polarization strategy}, volume = {64}, year = {2025}, }
• (2025). Enantioselective acylation of benzylic C(sp3)−H bond enabled by a cooperative photoredox and N-heterocyclic carbene catalysis. ANGEW, 64(19), e202421151. (www)

  @article{ , abstract = {Organocatalyzed direct and asymmetric functionalization of benzylic C(sp 3 )─H bond is attractive yet challenging. Herein, we report the enantioselective acylation of benzylic C(sp 3 )─H bond via a cooperative photoredox and N-heterocyclic carbene (NHC) catalysis, affording the corresponding chiral α-aryl ketones in moderate to good yields with good to excellent enantioselectivities (up to 99:1 er). The rational design of novel NHCs guided by the initial evaluation of available catalysts and their application promotes the asymmetric transformation. Mechanistic experiments and density functional theory (DFT) calculations support the formation of benzyl radical and ketyl radical intermediates and rationalize the coupling of these radical species via open-shell singlet transition states to be the enantiodetermining step. This redox neutral protocol features mild conditions and is free of transition-metals (TMs) and pre-functionalized radical precursors.}, archive = {J_ANGEW}, author = {Cao-Bo Li and Xue-Ning Li and Zhi-Cheng Li and Jikun Li and Zhi-Xiang Wang and Zhong-Hua Gao and Song Ye}, doi = {10.1002/anie.202421151}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202421151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective acylation of benzylic C(sp3)−H bond enabled by a cooperative photoredox and N-heterocyclic carbene catalysis}, volume = {64}, year = {2025}, }
• (2025). Chemical process development in the pharmaceutical industry in Europe—Insights and perspectives from industry scientists. ANGEW, 64(19), e202420719. (www)

  @article{ , abstract = {Chemical process development is a critical component in the development process for active pharmaceutical ingredients (APIs). With interfaces to drug discovery and API manufacturing, chemical process development activities must deliver scalable, safe, cost-efficient, sustainable, and reliable processes for novel as well as marketed APIs. Despite its importance for the pharmaceutical industry and society, the domain of chemical process development, together with its advances and challenges, is often not well known to nonpractitioners. As industry scientists, we provide a scientific perspective on the state of affairs in chemical process development, which we believe will be of value to a broader audience, including academic researchers, students, and professionals from related fields.}, archive = {J_ANGEW}, author = {Joachim Krueger and André P. Dieskau and Jorma Hassfeld and Joerg Gries and Oliver Block and Hilmar Weinmann and Daniel Kaufmann and Stefan Hildbrand and Volker Kraft and Robert Moeckel and Juan R. Dehli and Ulrich Scholz and Carl Friedrich Nising}, doi = {10.1002/anie.202420719}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202420719}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical process development in the pharmaceutical industry in Europe—Insights and perspectives from industry scientists}, volume = {64}, year = {2025}, }
• (2025). Rational screening of siloxane molecules as electrolyte additives for high-temperature sodium-ion batteries. ANGEW, 64(19), e202420573. (www)

  @article{ , abstract = {Sodium-ion batteries hold great promise for large-scale energy storage but face significant challenges at extreme temperatures. Especially at high temperatures, side reactions and electrode dissolution are exacerbated by repeated cycling. It is, therefore, essential to optimize the electrolyte formulation. Here, a series of siloxane molecules are screened to boost the high-temperature performance of the anode materials in SIBs. Octamethyltrisiloxane (MDM), as a result of this screening, prefers to interact with anions due to the unique electron-donating of Si→CH 3 . This association then weakens the P─F bond and facilitates the formation of a NaF-rich solid electrolyte interphase. Additionally, MDM inhibits the hydrolysis of PF 6 − , reducing the deleterious species in the electrolyte. Therefore, commercial Sn microparticles show a reversible capacity of 752 mAh g −1 at 60 °C after 750 cycles at 2 A g −1 , much better than the case without MDM. This result exceeds the reported data at high temperatures. MDM as an electrolyte additive also improves the high-temperature performance of Bi and hard carbon. The results provide useful guidance for the rational selection of electrolyte additives for high-temperature sodium-ion batteries.}, archive = {J_ANGEW}, author = {Yanan Sun and Cheng Zheng and Qian Yao and Hongyu Lv and Xiaojian Ma and Jian Yang}, doi = {10.1002/anie.202420573}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202420573}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational screening of siloxane molecules as electrolyte additives for high-temperature sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Unlocking the ConPeT mechanism: Correspondence on “Catalytic asymmetric redox-neutral [3 + 2] photocycloadditions of cyclopropyl ketones with vinylazaarenes enabled by consecutive photoinduced electron transfer”. ANGEW, 64(19), e202420009. (www)

  @article{ , abstract = {Recently, in a communication to this journal, Qiao, Jang, and coworkers described an asymmetric photoredox reaction promoted by TADF cyanoarene photocatalysts (specifically 4DPAPN (3,4,5,6-tetrakis(diphenylamino)phthalonitrile)). The authors claimed that the high reduction potential required for the reaction in acetonitrile was achieved by the radical anion of the photocatalyst in its excited state, which initiated the reaction. This mechanism is usually named consecutive photoinduced electron transfer (ConPeT), in which two photons are involved: the first one to excite the photocatalyst and generate the radical anion 4DPAPN •– and the second photon to promote 4DPAPN •– to its excited state * 4DPAPN •– . Employing ultrafast transient absorption spectroscopy, here we report that, although two photons are indeed involved in this transformation, the excited state * 4DPAPN •– is short-lived, not emissive, and not quenched by the organic substrate employed in the reaction, opposite to what was claimed by the authors. The photocatalyst in the excited state * 4DPAPN •– can generate a solvated electron that is able to reduce the substrate involved in this chemistry. It is worth noting that a different photochemical mechanism is likely to be operative in CH 2 Cl 2 , where solvated electrons are much less stabilized and reduction of the solvent might occur.}, archive = {J_ANGEW}, author = {Marco Villa and Andrea Fermi and Francesco Calogero and Andrea Gualandi and Paola Franchi and Marco Lucarini and Barbara Ventura and Pier Giorgio Cozzi and Paola Ceroni}, doi = {10.1002/anie.202420009}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202420009}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking the ConPeT mechanism: Correspondence on “Catalytic asymmetric redox-neutral [3 + 2] photocycloadditions of cyclopropyl ketones with vinylazaarenes enabled by consecutive photoinduced electron transfer”}, volume = {64}, year = {2025}, }
• (2025). Single-cell force spectroscopy uncovers root zone- and bacteria-specific interactions. ANGEW, 64(19), e202419510. (www)

  @article{ , abstract = {Understanding root–bacteria interactions with plant growth-promoting rhizobacteria (PGPR) is key to developing effective biofertilizers for sustainable agriculture. We performed single-cell force spectroscopy using the atomic force microscope (AFM) to study the primary attachment of two PGPR, Bacillus velezensis and Pseudomonas defensor , to different regions of Arabidopsis thaliana roots. Force measurements with individual cells uncovered distinct attachment strategies by each strain, involving binding via micrometer-long polymers from both bacteria and root surfaces. Flagella differentially affected the binding interactions of each PGPR; their removal altered binding characteristics differently for each strain, highlighting the importance of flagella in early root colonization. Using silica beads to mimic the negatively charged bacteria, we demonstrated the influence of electrostatic forces on root–bacteria interactions. We also examined interactions with abiotic surfaces of varying surface energies, revealing the roles of hydrophilic and hydrophobic forces in initial binding. Our measurements show that differences in the physicochemical properties of bacteria and roots are responsible for variations in primary attachment strategies between PGPR strains and root regions. Parallel fluorescence measurements corroborated our AFM single-cell analysis. Overall, our results provide a nanoscale view of bacterial attachment to roots, offering key insights into how beneficial bacteria colonize roots, crucial for enhancing biofertilizer effectiveness.}, archive = {J_ANGEW}, author = {Yilei Xue and Mackenzie Eli W. Loranger and Yifan Jia and Nesha May O. Andoy and Wolfgang Moeder and Keiko Yoshioka and Ruby May A. Sullan}, doi = {10.1002/anie.202419510}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202419510}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-cell force spectroscopy uncovers root zone- and bacteria-specific interactions}, volume = {64}, year = {2025}, }
• (2025). Combining two mechanistically distinct reactions from a single iron complex: A tandem approach to thermally stable and recyclable polymers. ANGEW, 64(19), e202418908. (www)

  @article{ , abstract = {A shift from petrochemical feedstocks to renewable resources has the potential to address some of the environmental concerns associated with petrochemical extraction, thereby making the production of plastics a sustainable process. Consequently, there is a growing interest in the development of selective techniques for the conversion of abundant renewable feedstocks into environmentally friendly polymers. We present a one-pot iron-based catalytic system, which is active, efficient, and selective under mild conditions for producing of renewable copolymers. We demonstrate that this system can function as a tandem catalyst for the production of poly(silylether)s (PSEs), followed by the ring-opening polymerization of lactide. This effective approach provides direct access to novel thermally stable copolymers. Furthermore, we detail the quantitative chemical recycling of such copolymers, underscoring their potential as new environmentally friendly materials.}, archive = {J_ANGEW}, author = {Kanokon Upitak and Christophe M. Thomas}, doi = {10.1002/anie.202418908}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202418908}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Combining two mechanistically distinct reactions from a single iron complex: A tandem approach to thermally stable and recyclable polymers}, volume = {64}, year = {2025}, }
• (2025). Merging hydrogen-atom-transfer and the truce-smiles rearrangement for synthesis of β-arylethylamines from unactivated allylsulfonamides. ANGEW, 64(19), e202418869. (www)

  @article{ , abstract = {Arylethylamines are crucial elements in pharmaceutical molecules, making methods for their synthesis highly significant. The Truce–Smiles rearrangement is a well-developed strategy to synthesize arylethylamine motifs via aryl migration. However, most examples require amide substrates to activate the alkene to attack by a radical precursor. This strategy both limits the product scope to amide-containing compounds as well as necessitating the incorporation of specific functional groups arising from the initial radical addition. In this work, we overcome these limitations, delivering a hydrogen-atom transfer from a cobalt catalyst to unactivated alkenes to yield β-arylethylamines with simple alkyl chains. DFT studies reveal that increasing the steric hindrance in at least one of the ortho positions on the migrating aromatic group promotes ipso over ortho addition, a selectivity that contrasts with previous methods.}, archive = {J_ANGEW}, author = {Hanqi Zhou and Danijela Lunic and Nil Sanosa and Diego Sampedro and Ignacio Funes-Ardoiz and Christopher J. Teskey}, doi = {10.1002/anie.202418869}, journal = {Angewandte Chemie International Edition}, month = {5}, number = {19}, pages = {e202418869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Merging hydrogen-atom-transfer and the truce-smiles rearrangement for synthesis of β-arylethylamines from unactivated allylsulfonamides}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Chiral communication between enantiomeric sergeants and achiral soldiers in racemic triblock copolymers with heterochiral cores for triggering multiple helicity inversions. ANGEW, 64(18), e202581862. (www)

  @article{ , archive = {J_ANGEW}, author = {Zixiang He and Haotian Ma and Zeyu Tang and Xiaoxiao Cheng and Wei Zhang}, doi = {10.1002/anie.202581862}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202581862}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Chiral communication between enantiomeric sergeants and achiral soldiers in racemic triblock copolymers with heterochiral cores for triggering multiple helicity inversions}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Enabling unconventional “Alternating-distal” n2 reduction pathway for efficient ammonia electrosynthesis. ANGEW, 64(18), e202581861. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202581861}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202581861}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Enabling unconventional “Alternating-distal” n2 reduction pathway for efficient ammonia electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: High-throughput computational screening of small molecular crystals for sustainable piezoelectric materials (Angew. chem. int. ed. 18/2025). ANGEW, 64(18), e202507410. (www)

  @article{ , archive = {J_ANGEW}, author = {Shubham Vishnoi and Geetu Kumari and Robert Guest and Pierre-André Cazade and Sarah Guerin}, doi = {10.1002/anie.202507410}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202507410}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: High-throughput computational screening of small molecular crystals for sustainable piezoelectric materials (Angew. chem. int. ed. 18/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Straightforward formation of borirenes from boroles and dialkynes (Angew. chem. int. ed. 18/2025). ANGEW, 64(18), e202506308. (www)

  @article{ , archive = {J_ANGEW}, author = {Pedro H. R. Oliveira and Marieli O. Rodrigues and Caren D. G. da Silva and Josina Bohlen and Merle Arrowsmith and Arumugam Jayaraman and Lukas Lubczyk and Felipe Fantuzzi and Eufrânio N. da Silva Júnior and Holger Braunschweig}, doi = {10.1002/anie.202506308}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202506308}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Straightforward formation of borirenes from boroles and dialkynes (Angew. chem. int. ed. 18/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Data-driven accelerated discovery coupled with precise synthesis of single-atom catalysts for robust and efficient water purification (Angew. chem. int. ed. 18/2025). ANGEW, 64(18), e202506096. (www)

  @article{ , archive = {J_ANGEW}, author = {Keng-Qiang Zhong and Fu-Yun Yu and Di Zhang and Zheng-Hao Li and Dong-Hua Xie and Ting-Ting Li and Yun Zhang and Li Yuan and Hao Li and Zhen-Yu Wu and Guo-Ping Sheng}, doi = {10.1002/anie.202506096}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202506096}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Data-driven accelerated discovery coupled with precise synthesis of single-atom catalysts for robust and efficient water purification (Angew. chem. int. ed. 18/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Elucidating the role of electric fields in fe oxidation via an environmental atom probe (Angew. chem. int. ed. 18/2025). ANGEW, 64(18), e202506093. (www)

  @article{ , archive = {J_ANGEW}, author = {Sten V. Lambeets and Naseeha Cardwell and Isaac Onyango and Mark G. Wirth and Eric Vo and Yong Wang and Pierre Gaspard and Cornelius F. Ivory and Daniel E. Perea and hierry Visart de Bocarmé and Jean-Sabin McEwen}, doi = {10.1002/anie.202506093}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202506093}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Elucidating the role of electric fields in fe oxidation via an environmental atom probe (Angew. chem. int. ed. 18/2025)}, volume = {64}, year = {2025}, }
• (2025). Nikki a. thiele. ANGEW, 64(18), e202504787. (www)

  @article{ , archive = {J_ANGEW}, author = {Nikki A. Thiele}, doi = {10.1002/anie.202504787}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202504787}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nikki a. thiele}, volume = {64}, year = {2025}, }
• (2025). Enabling unconventional “Alternating-distal” n2 reduction pathway for efficient ammonia electrosynthesis. ANGEW, 64(18), e202502957. (www)

  @article{ , abstract = {The general understanding on the reaction path is that the electrocatalytic N 2 reduction follows either individual associative alternating or distal pathways, where efficient N 2 activation and selective NH 3 production are very challenging. Herein, an unconventional “alternating-distal” pathway was achieved by shifting the “*NHNH 2 →*NH 2 NH 2 ” to “*NHNH 2 →*NH + NH 3 ” step to boost NH 3 synthesis with an amorphous CeMnO x electrocatalyst. In this unconventional process, N 2 activation was realized through π back donation on the Mn site, while the Mn/Ce dual active sites could regulate the intermediate configurations to avoid the nitrogen-containing by-product formation. Such “alternating-distal” pathway was affirmed by in situ spectroscopic analyses and theoretical calculations. In a neutral media, an average ammonia production rate of 82.8 µg h −1 mg −1 and an outstanding Faradaic efficiency of 37.3% were attained. This work validated an unconventional mechanism in electrocatalytic ammonia synthesis, which might be extended to other catalytic process with multiple possible reaction paths.}, archive = {J_ANGEW}, author = {Chu Zhang and Qing Wang and Zeyu Li and Hengjie Liu and Lixiang Zhong and Jiawei Liu and Zheng Wang and Runjie Wu and Pin Song and Wen-Jie Chen and Zeming Qi and Chunshuang Yan and Li Song and Qingyu Yan and Chade Lv}, doi = {10.1002/anie.202502957}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202502957}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enabling unconventional “Alternating-distal” n2 reduction pathway for efficient ammonia electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Oxygen vacancy-enhanced selectivity in aerobic oxidation of benzene to phenol over TiO2 photocatalysts. ANGEW, 64(18), e202502823. (www)

  @article{ , abstract = {Photocatalytic oxidation of benzene to phenol using molecular oxygen (O 2 ) is a promising alternative to the traditional cumene process. However, the selectivity toward phenol is often poor due to the ring-opening reaction induced by the superoxide radical (⋅O 2 − ), which is predominantly produced from the single-electron reduction of O 2 . Herein, we demonstrate that introducing abundant oxygen vacancies (OVs) on the surface of titanium dioxide (TiO 2 ) facilitates the activation of O 2 through a two-electron reduction process instead of a single-electron reduction. This effectively suppresses the generation of ⋅O 2 − , thereby reducing phenol decomposition and significantly enhancing the selectivity. In addition, these OVs can trap the electrons to promote chare separation and serve as the adsorption sites for O 2 activation. As a result, the introduction of abundant OVs on the surface of TiO 2 not only enhances phenol yield but also importantly improves selectivity toward phenol. This finding enriches our understanding of how OVs influence reaction pathways and product selectivity, providing valuable insights for the design and tailoring of OV-rich photocatalysts for selective organic oxygenations.}, archive = {J_ANGEW}, author = {Shengyang Zhong and Dexi Yu and Yuhui Ma and Yuhong Lin and Xiaoyi Wang and Zhenzhen Yu and Meirong Huang and Yidong Hou and Masakazu Anpo and Jimmy C. Yu and Jinshui Zhang and Xinchen Wang}, doi = {10.1002/anie.202502823}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202502823}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen vacancy-enhanced selectivity in aerobic oxidation of benzene to phenol over TiO2 photocatalysts}, volume = {64}, year = {2025}, }
• (2025). Unveiling the intrinsic superior SHG performance of ce4+ fluoride masked by subtle ce3+ impurity and its effective removal. ANGEW, 64(18), e202502143. (www)

  @article{ , abstract = {Owing to its unique electronic configuration [Xe]4 f 0 , Ce 4+ -compound is a highly desired in the field of advanced nonlinear optical materials, yet its synthesis remains a great challange. Herein, we report a series of cerium fluorides, including a pure Ce 4+ -fluoride, high-performance Na 2 (Ce 4+ )F 6 ; three mixed valance state samples, (Mix1–3, with increasing Ce 3+ concentration); and a fully reduced pure Ce 3+ -fluoride Na 1.5 (Ce 3+ ) 1.5 F 6 . In particular, Na 2 (Ce 4+ )F 6 , shows an SHG response (4×KDP), and a wide band gap (4.77 eV), which are the strongest and widest among all Ce-containing materials to date. With systematic studies, we demonstrate that the subtle Ce 3+ impurity significantly reduces performance. By being aware of this fact and consciously controlling experimental conditions, we can ensure the synthesis of pure Na 2 (Ce 4+ )F 6 , which exhibits excellent overall performance and shows great potential for future applications. This work not only reinforced the crucial role of Ce 4+ in significantly enhancing the key performance, but also provided invaluable experimental evidence and theoretical support for the future design of more efficient and superior functional materials.}, archive = {J_ANGEW}, author = {Meng-Yue Li and Xin Liu and Rui Xi Wang and Li-Ming Wu and Ling Chen and Qi Wu}, doi = {10.1002/anie.202502143}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202502143}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the intrinsic superior SHG performance of ce4+ fluoride masked by subtle ce3+ impurity and its effective removal}, volume = {64}, year = {2025}, }
• (2025). Light-intersecting photoclick reactions for bioorthogonal labeling on single cells: Dibenzo[b,f][1,4,5]thiadiazepine-11,11-dioxide as a photoswitchable reporter. ANGEW, 64(18), e202501936. (www)

  @article{ , abstract = {The advancement of ring-strain preloaded dipolaro-/dienophiles plays a crucial role in bioorthogonal chemistry, enabling multiple high-precision conjugations toward biomolecules simultaneously. However, durability of these ring-strain preloaded reagents in vivo is a concern, as the ring-strain is not reloadable once released during delivery process. In situ conversion of light-energy into ring-strain is a promising approach to ensure both biostability and spatiotemporal control endowed by light. Herein, we advance a seven-membered cyclic azobenzene photoswitch, dibenzo[ b , f ][1,4,5]thiadiazepine-11,11-dioxide (DBTDD), bridged by a sulphone moiety. The photoisomerization from Z -DBTDD to ring-strain-loaded E -DBTDD enables an accelerated cycloaddition with various photogenerated dipoles to establish novel photoclick reactions, featuring a dual-λ (405 nm+445 nm) synergistic control. In reactions with monoarylsydnones, a higher photo-stationary ratio of E -DBTDD, achieved by varying the power density of 445 nm laser, presented an ultrafast cycloaddition rate ( k E =6.6×10 7 M −1 s −1 ) with a 13.8-fold acceleration compared with Z -DBTDD, which is superior to established ring-strain reporters (e.g., BCN-OH, sTCO-OH, DBTD). Then, bioorthogonal photoclick labeling of DBTDD tagged artificial phospholipid on living cell membranes was realized at subcellular resolution via an essential dual-λ intersecting lithography with an elevated efficiency by adjusting the 445 nm power density.}, archive = {J_ANGEW}, author = {Zhihao Liu and Cefei Zhang and Sitong Li and Yuqiao Zhou and Fengying Lan and Xiaohu Zhao and Zhishan Su and Changwei Hu and Pengchi Deng and Zhipeng Yu}, doi = {10.1002/anie.202501936}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501936}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-intersecting photoclick reactions for bioorthogonal labeling on single cells: Dibenzo[b,f][1,4,5]thiadiazepine-11,11-dioxide as a photoswitchable reporter}, volume = {64}, year = {2025}, }
• (2025). Ionic-fence effect in au nanoparticle-loaded UiO-66 Metal–Organic frameworks for highly chemoselective hydrogenation. ANGEW, 64(18), e202501821. (www)

  @article{ , abstract = {The chemoselective reaction are vital for fine chemicals, which requires economical and environmentally friendly catalysts. In order to improve the selectivity of multi-reaction competition, herein, we propose a novel ionic-fence strategy to synthesize heterogeneous catalyst for efficient hydrogenation. Practically, UIO-66 metal–organic frameworks (MOF) modified with pyridinium-linker has been constructed through post-synthetic chains with paired anion via quaternization and ion exchange to form ionic-fence MOF (IFMOF-Cl), which can manage the adsorption mode of nitro substrate, further confine the formation of metal nanoparticles with high dispersity. The optimal Au@IFMOF-Cl catalyst demonstrates satisfactory selectivity for hydrogenation of nitro group compared to acetylene group in 4-nitrophenylacetylene. Specifically, it owns a high yield of 4-aminophenylacetylene (~97 %) with ultra-high catalytic efficiency (3880 h −1 TOF) and long stability, far superior to other catalysts without ionic fence effect. Adsorption experiments and density functional theory studies reveal that the incorporation of ionic fence could modulate the adsorption energy of nitro group, which is responsible for the high selectivity enhancement. Notably, this ionic-fence strategy exhibits comprehensive universality towards a wide range of substrates (23 kinds in total), providing a promising avenue for precisely engineering the internal microenvironments of catalysts to achieve highly selective synthesis of fine chemicals.}, archive = {J_ANGEW}, author = {Yicheng Zhong and Peisen Liao and Pingping Jiang and Yuhao Zhang and Jiawei Kang and Sizhuo Xie and Rongyu Feng and Yanan Fan and Qinghua Liu and Guangqin Li}, doi = {10.1002/anie.202501821}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501821}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ionic-fence effect in au nanoparticle-loaded UiO-66 Metal–Organic frameworks for highly chemoselective hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Atomic symbiotic-catalyst for low-temperature zinc-air battery. ANGEW, 64(18), e202501649. (www)

  @article{ , abstract = {Atomic-level designed electrocatalysts, including single-/dual-atom catalysts, have attracted extensive interests due to their maximized atom utilization efficiency and increased activity. Herein, a new electrocatalyst system termed as “atomic symbiotic-catalyst”, that marries the advantages of typical single-/dual-atom catalysts while addressing their respective weaknesses, was proposed. In atomic symbiotic-catalyst, single-atom MN x and local carbon defects formed under a specific thermodynamic condition, act synergistically to achieve high electrocatalytic activity and battery efficiency. This symbiotic-catalyst shows greater structural precision and preparation accessibility than those of dual-atom catalysts owing to its reduced complexity in chemical space. Meanwhile, it outperforms the intrinsic activities of conventional single-atom catalysts due to multi-active-sites synergistic effect. As a proof-of-concept study, an atomic symbiotic-catalyst comprising single-atom MnN 4 moieties and abundant sp 3 -hybridized carbon defects was constructed for low-temperature zinc-air battery, which exhibited a high peak power density of 76 mW cm −2 with long-term stability at −40 °C, representing a top-level performance of such batteries.}, archive = {J_ANGEW}, author = {Ge Meng and Zaimei Huang and Lei Tao and Zechao Zhuang and Qingcheng Zhang and Qilin Chen and Hui Yang and Huaping Zhao and Chenliang Ye and Yu Wang and Jian Zhang and Wei Chen and Shixuan Du and Yihuang Chen and Dingsheng Wang and Huile Jin and Yong Lei}, doi = {10.1002/anie.202501649}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501649}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic symbiotic-catalyst for low-temperature zinc-air battery}, volume = {64}, year = {2025}, }
• (2025). π-extended heli(aminoborane)s with highly bright circularly polarized luminescence and narrowband emission. ANGEW, 64(18), e202501645. (www)

  @article{ , abstract = {Helical molecular carbons (HMCs) possess high absorption/luminescence dissymmetry factors ( g abs / g lum ) and significant luminescence quantum yield ( Φ lum ), resulting in a high circularly polarized luminescence (CPL) brightness ( B CPL ), which is essential for the development of CPL materials for practical applications. Herein, we designed and synthesized a series of boron-nitrogen (BN)-doped HMCs, named π-extended heli(aminoborane)s ( E[10]HAB-A , E[10]HAB-B and E[10]HAB-C ), consisting of laterally π-extended [10]helicene skeleton with alternating N and B atoms at the inner rim. The aromaticity, electronic structures, and photophysical properties of E[10]HAB-A/B/C were systematically investigated through experiments and theoretical calculations. E[10]HAB-A/B/C displayed remarkable photophysical properties, including high molar extinction coefficient and bright narrowband emission. The isolated enantiomers of E[10]HAB-A/B/C exhibited intense circular dichroism (CD) and CPL, in which E[10]HAB-A shows g abs and g lum values up to 0.024 and 0.017, simultaneously with high Φ lum of 82 % and a narrow full width at half maximum of 16 nm. Accordingly, E[10]HAB-A exhibits a B CPL as high as 583 M −1 cm −1 , which is the largest value among the reported BN-doped HMCs. Our study indicates that inner rim BN-doping and π-extension are effective strategies to achieve high Φ lum and balanced g lum values in HMCs.}, archive = {J_ANGEW}, author = {Yang Yu and Chang Wang and Faan-Fung Hung and Long Jiang and Chi-Ming Che and Junzhi Liu}, doi = {10.1002/anie.202501645}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π-extended heli(aminoborane)s with highly bright circularly polarized luminescence and narrowband emission}, volume = {64}, year = {2025}, }
• (2025). Mapping the catalytic cycle of ru-catalyzed ammonia oxidation. ANGEW, 64(18), e202501617. (www)

  @article{ , abstract = {This study presents a mechanism of ammonia oxidation catalyzed by [ Ru II (NH 3 )][PF 6 ] 2 ( Ru =Ru(tpy)(dmabpy)) complexes. All intermediates, including the elusive [ Ru III (NH 2 )] 2+ and [ Ru IV (NH)] 2+ , were detected, with several intermediates characterized spectroscopically. The catalytic cycle follows multiple reaction pathways branching at the key intermediates [ Ru III (NH 2 )] 2+ and [ Ru II (N 2 H 4 )] 2+ . The competition between the pathways is influenced by ammonia concentration and the local proton concentration generated during electrooxidation at the anode. In the N−N bond-forming steps, dimerization of [ Ru III (NH 2 )] 2+ and nucleophilic attack of [ Ru IV (NH)] 2+ by ammonia compete, while in the subsequent [ Ru II (N 2 H 4 )] 2+ oxidation, direct oxidation competes with proton-catalyzed disproportionation. These findings provide molecular-level insights into the catalytic cycle and offer guidance for developing more efficient ruthenium-based ammonia oxidation catalysts.}, archive = {J_ANGEW}, author = {Bowei Yuan and Guilherme L. Tripodi and M.T.G.M. Derks and Aleksandr Y. Pereverzev and Shaodong Zhou and Jana Roithová}, doi = {10.1002/anie.202501617}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501617}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mapping the catalytic cycle of ru-catalyzed ammonia oxidation}, volume = {64}, year = {2025}, }
• (2025). Ultrasensitive gas sensor of mixed-dimensional heterostructures combining borophene and BC2N quantum dots: Enhanced detection through binary cooperative effects. ANGEW, 64(18), e202501550. (www)

  @article{ , abstract = {The emergence of mixed-dimensional van der Waals heterostructures has inspired worldwide interests in recent years, opening up new avenues for potential nanotechnology applications. Herein, we proposed a mixed-dimensional heterostructure composed of borophene sheets and BC 2 N quantum dots. The gas sensing performance of the heterostructure was evaluated through a combination of theoretical calculations and experimental methods. Specifically, first-principles calculation results show that NO 2 is the most strongly interacting molecule and induces the largest amount of charge transfer between the molecule and the heterostructure, suggesting exceptional sensitivity and selectivity of the heterostructure to NO 2 gas. Following the theoretical insights, a borophene-BC 2 N heterostructure gas sensor was developed and its gas detection abilities were assessed with exposure to various gases at room temperature. Remarkably, this sensor displayed a sensitivity of 1170 % to 30 ppm NO 2 and remain a high sensitivity of 108 % even to 0.2 ppm NO 2 . These results highlight borophene-BC 2 N heterostructure as a superior NO 2 gas sensor, demonstrating enhanced sensing via BC 2 N quantum dots and integrated theoretical-experimental approaches.}, archive = {J_ANGEW}, author = {Zhilin Zhao and Xiang Liu and Yi Liu and Zitong Wu and Ke Xiong and Guoan Tai}, doi = {10.1002/anie.202501550}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrasensitive gas sensor of mixed-dimensional heterostructures combining borophene and BC2N quantum dots: Enhanced detection through binary cooperative effects}, volume = {64}, year = {2025}, }
• (2025). Silver molybdate nanoparticles for enhanced tumor immunotherapy through pyroptosis conversion and ferroptosis induction. ANGEW, 64(18), e202501530. (www)

  @article{ , abstract = {Pyroptosis holds great potential in tumor therapy due to its strong immunogenicity. Several strategies, including ion interference therapy (IIT), are developed to induce pyroptosis. However, the mechanism by which metal oxoanions induced pyroptosis remained unclear. It was reported that MoO 4 2− ions could stimulate immune responses, but their pyroptosis-inducing mechanisms were not fully understood. Herein, we synthesized uniform and dispersed silver molybdate (Ag 2 MoO 4 ) nanoparticles (AMO) via a solvothermal method. AMO responded to H 2 O 2 and glutathione (GSH) stimuli, releasing Ag + and MoO 4 2− ions, generating reactive oxygen species (ROS), and depleting GSH, thereby inducing ferroptosis and pyroptosis. The MoO 4 2− also inhibited cell migration and upregulated GSDME expression, converting apoptosis into caspase-3/GSDME-mediated pyroptosis. Additionally, DNA damage and ROS activated the cGAS-STING pathway, enhancing innate immunity. In vivo experiments demonstrated that the combination of AMO and the immune checkpoint inhibitor αPD-1 significantly inhibited tumor growth. This combination promoted dendritic cells (DCs) maturation, increased effector T cell numbers, induced M1 macrophage polarization, and alleviated immunosuppression. This study contributed to a deeper understanding of metal oxoanion-mediated pyroptosis, supporting its potential application in cancer immunotherapy.}, archive = {J_ANGEW}, author = {Hao Chen and Binbin Ding and Jia Tan and Qi Meng and Jing Li and Wenying Zhang and Pan Zheng and Bin Liu and Ping'an Ma and Jun Lin}, doi = {10.1002/anie.202501530}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501530}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Silver molybdate nanoparticles for enhanced tumor immunotherapy through pyroptosis conversion and ferroptosis induction}, volume = {64}, year = {2025}, }
• (2025). Large-area, ultra-thin organic films with both photochromic and phosphorescence properties. ANGEW, 64(18), e202501448. (www)

  @article{ , abstract = {Polyethylene terephthalate ( PET ), polystyrene ( PS ), and polyvinyl chloride ( PVC ) are the most commonly used polymers in plastic products. Therefore, endowing these polymers with unique optical properties would significantly enhance their overall technological value. Herein, we synthesized a phosphorescent molecule, 2,2′-diphenyl-3,3′-bibenzofuran ( DBF ), with notable reversible photochromic properties (switching between colorless and deep red) as the guest and constructed a doped system with the above polymers as the hosts. All doped materials exhibited both room-temperature phosphorescence and reversible photochromic properties. The guest molecule exhibited strong reversible cyclization activity and small conformational changes during the reaction process, as well as moderate rigidity of the host matrix, which enabled the uncommon coexistence of these two properties in the doped system. Finally, DBF/PET was successfully formed into a transparent and uniform film with a length of 200 m, a width of 20 cm, a thickness of only 60–70 μm. This film exhibited excellent thermal-stability, sensitivity, and resistance to photo-fatigue, indicating its applicability in industrial production.}, archive = {J_ANGEW}, author = {Chuanli Chen and Weijing Zhang and Zeng Wang and Xin Wang and Jianhui Yang and Yue Ren and Ziqi Huang and Wenbo Dai and Xiaobo Huang and Yunxiang Lei}, doi = {10.1002/anie.202501448}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501448}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Large-area, ultra-thin organic films with both photochromic and phosphorescence properties}, volume = {64}, year = {2025}, }
• (2025). 3D cluster-based covalent organic framework for efficient CO2 photoreduction. ANGEW, 64(18), e202501391. (www)

  @article{ , abstract = {Copper clusters exhibit superior catalytic activity for the CO 2 reduction reaction (CO 2 RR), and their defined structures endow them with unique advantages for modeling the catalytic mechanism at the atomic level. Additionally, the construction of highly stable and regularly structured covalent organic frameworks (COFs) based on copper clusters still presents significant challenges. Herein, we reported two highly stable and reactive cluster-based COFs (termed Cu 4 COF-1 and Cu 4 COF-2) constructed via a stepwise assembly strategy. The epitaxially amino-modified Cu 4 cluster (Cu 4 - NH 2 ) was initially synthesized based on coordination bonds. Then, Cu 4 COFs were obtained by the covalent linkage of Cu 4 - NH 2 clusters and organic linkers. Compared with isolated Cu 4 clusters, the Cu 4 COFs exhibit greater stability, a narrower band gap, a larger specific surface area, and better charge transfer ability, which endow them with superior photocatalytic CO 2 RR performance under visible light. In-situ infrared spectroscopy and density functional theory (DFT) calculations revealed that the covalently linked Cu 4 COFs could efficiently lower the energy barrier for the formation of the critical *COOH intermediate, thereby enhancing the photocatalytic activity. This study offers a solid basis for the atomically precise construction of novel metal-cluster-based COF catalysts.}, archive = {J_ANGEW}, author = {Yue Xu and Jian-Peng Dong and Le Wang and Rong-Li Geng and Rui Wang and Ya-Nan Si and Shuang-Quan Zang and Thomas C. W. Mak}, doi = {10.1002/anie.202501391}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {3D cluster-based covalent organic framework for efficient CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). High-throughput computational screening of small molecular crystals for sustainable piezoelectric materials. ANGEW, 64(18), e202501232. (www)

  @article{ , abstract = {Organic molecular crystals are ideally placed to become next-generation piezoelectric materials due to their diverse chemistries that can be used to engineer tailor-made solid-state assemblies. Using crystal engineering principles and techniques such as cocrystallization, these materials can be engineered to have a wide range of electromechanical properties. For materials that have been structurally characterized by methods such as X-ray diffraction, computational chemistry is an effective tool to predict their electromechanical properties, allowing researchers to screen these molecular crystals and identify materials best suited to their chosen application. Here, we present our database of small molecular crystals and their density functional theory (DFT) predicted electromechanical properties, CrystalDFT ( https://actuatelab.ie/CrystalDFT ). We highlight the broad range of electromechanical properties amongst this primary dataset, and in particular, the high number of crystals that have a naturally occurring (unpoled) longitudinal piezoelectric response ( d 11 / d 22 / d 33 ). This longitudinal electromechanical coupling is a prerequisite for several conventional sensing and energy harvesting applications, the presence of which is notably rare amongst the literature on biomolecular crystal piezoelectricity to date.}, archive = {J_ANGEW}, author = {Shubham Vishnoi and Geetu Kumari and Robert Guest and Pierre-André Cazade and Sarah Guerin}, doi = {10.1002/anie.202501232}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501232}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-throughput computational screening of small molecular crystals for sustainable piezoelectric materials}, volume = {64}, year = {2025}, }
• (2025). Cyclodextrin-initiated N-carboxyanhydride polymerization for the design of stereostructural dobby polypeptides with jellyfish-type architecture. ANGEW, 64(18), e202501058. (www)

  @article{ , abstract = {Strict criteria of biomedical materials in synthesis efficiency, structure determinacy, and biological safety pose formidable challenges for the synthesis of dobby polypeptides. Herein we reported a cyclodextrin (CD)-initiated, 1,1,3,3-Tetramethylguanidine (TMG)-catalyzed one-step N-carboxyanhydride (NCA) ring-opening polymerization (ROP) strategy to synthesize a series of dobby polypeptides that fulfill the criteria of biomedical materials. By leveraging TMG's catalytic mechanisms in nucleophilicity enhancement for CD hydroxyl groups and active center creation for NCA monomers, this strategy achieves efficient NCA polymerization within 2 hours and high monomer conversion up to 93.5 %. Meticulous characterizations illustrate that CD-centric polypeptides present jellyfish-type stereochemical structures, in which the arm number, length, orientation and initiation sites are precisely determined. Simultaneously, CD-centric polypeptides possess excellent self-assembling capacities to guide nanostructure fabrication, exhibiting broad-spectrum small-molecule drug encapsulation. Additionally, natural CD applied in multipoint initiation of core-first NCA ROP fundamentally improves the biodegradability and biosafety of dobby polypeptides, thus facilitating their biomedical applications.}, archive = {J_ANGEW}, author = {Guoqiao Xu and Guping Tang and Hongzhen Bai}, doi = {10.1002/anie.202501058}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501058}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyclodextrin-initiated N-carboxyanhydride polymerization for the design of stereostructural dobby polypeptides with jellyfish-type architecture}, volume = {64}, year = {2025}, }
• (2025). Oxygen-mediated hydrogen spillover promotes stable synthesis of vinyl chloride on ru single-atom catalysts. ANGEW, 64(18), e202501040. (www)

  @article{ , abstract = {Ru single-atom catalysts hold great promise for the robust synthesis of vinyl chloride through acetylene hydrochlorination. However, the easy over-chlorination of Ru atoms during reaction suppress the catalytic activity and stability. Herein, we have synthesized an oxygen doped Ru single-atom catalyst by a sequential oxygen etching strategy, which delivers the remarkable yield of vinyl chloride monomer (>99.38 %) and stability (>900 h, 180 h −1 ), far beyond those reported Ru counterparts. Experimental results and theoretical calculations reveal that the asymmetric structure of single-atom Ru promotes an unconventional oxygen-mediated hydrogen spillover after the activation of hydrogen chloride, which enables the reaction to proceed through Eley-Rideal mechanism with a reduced energy barrier of acetylene hydrochlorination compared to the traditional Langmuir–Hinshelwood pathway. As a result, the enhanced reaction kinetics further restrict over-chlorination of single-atom Ru, thereby ensuring the excellent durability. This work offers a strategy for designing multifunctional catalysts with enhanced performances for acetylene hydrochlorination.}, archive = {J_ANGEW}, author = {Yurui Fan and Haomiao Xu and Mingming Wang and Zhisong Liu and Hongyuan Qi and Wenjun Huang and Lei Ma and Feng Yu and Zan Qu and Pengfei Xie and Bin Dai and Naiqiang Yan}, doi = {10.1002/anie.202501040}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202501040}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen-mediated hydrogen spillover promotes stable synthesis of vinyl chloride on ru single-atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Redox-mediated TEMPO-based donor-acceptor covalent organic framework for efficient photo-induced hydrogen peroxide generation. ANGEW, 64(18), e202500924. (www)

  @article{ , abstract = {Molecular engineering of covalent organic frameworks (COFs) offers an alternative approach to conventional anthraquinone oxidation via photo-induced H 2 O 2 production from O 2 reduction. Despite their potential, reported photocatalysts suffer limited proton mobility, low selectivity, and insufficient charge separation and utilization. Herein, we report a nitroxyl radical (TEMPO) decorated two-dimensional (2D) donor-acceptor (D-A)-COF photocatalyst via a one-pot strategy. Under visible light irradiation, highly crystalline TAPP-TPDA-TEMPO-COF ( TT-T-COF ) exhibits a remarkable photocatalytic H 2 O 2 yield of 10066 μmol g −1 h −1 in two-phase water-benzyl alcohol (10 % BA) system through direct two-electron (2 e − ) pathway. The mechanistic study by DFT calculations and in situ DRIFT spectra suggests Yeager-type adsorption of *O 2 ⋅ − intermediate on the nitroxyl radical site (N−O⋅). The efficient photocatalytic performance and stability of TT-T-COF are attributed to the involvement of the nitroxyl radical, which enhances selective O 2 adsorption, establishes a distinct electron density distribution, and facilitates photogenerated charge separation compared to TT-HT-COF and TT-COF counterparts. This study uncovers a new perspective for constructing metal-free, redox-mediated radical-based COFs for sustainable energy conversion, storage, and biomedical applications.}, archive = {J_ANGEW}, author = {Junlan Chen and Shichen Yan and Futong Wang and Fuwen Lin and Jing Lin and Rahul Anil Borse and Yaobing Wang}, doi = {10.1002/anie.202500924}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-mediated TEMPO-based donor-acceptor covalent organic framework for efficient photo-induced hydrogen peroxide generation}, volume = {64}, year = {2025}, }
• (2025). Selective hydrogenolysis of biomass-derived aromatic alcohols over 2D-Mo2COx MXene by a reversible redox-relay mechanism. ANGEW, 64(18), e202500881. (www)

  @article{ , abstract = {Selective CH 2 −OH hydrogenolysis of biomass-derived aromatic alcohols to produce methyl aromatics is crucial for synthesizing sustainable fuels and chemicals; yet traditional metal–acid bifunctional catalysis possesses significant challenges owing to its complex reaction network. Herein, a 2D-Mo 2 CO x MXene was fabricated, demonstrating an efficient hydrogenolysis of 5-hydroxymethyl furfural into 5-methyl furfural, achieving an impressive yield (99.5 %) at the mild reaction temperature of 90 °C. Catalytic mechanism investigations reveal that 2D-Mo 2 CO x facilitate the activation and cleavage of the CH 2 −OH bond through a redox mechanism, driven by the strong CH 2 −OH affinity of the Mo–Mo metallic plane. In the absence of H 2 , hydrogen from O−H group is the source for methyl formation from CH 2 −OH. Under a H 2 atmosphere, H 2 is activated to remove residual oxygen species, boosting selective hydrogenolysis while suppressing furan and CH=O hydrogenation. Furthermore, the catalyst exhibited broad universality for synthesizing methyl aromatics from various furfuryl alcohols, benzyl alcohols, and hydroxycyclopentenones. This study presents a novel redox-relay mechanism in advanced MXene catalysis, offering a straightforward hydrogenolysis pathway for challenging substrates.}, archive = {J_ANGEW}, author = {Yangye Hu and Jianxin Cai and Guoqiang Shen and Zepeng Zhao and Yong Liu and Shuting Liu and Shaobo Tu and Yajie Tian and Haijiao Lu and Jun Wang and Shuguang Deng and Qiang Deng}, doi = {10.1002/anie.202500881}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500881}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective hydrogenolysis of biomass-derived aromatic alcohols over 2D-Mo2COx MXene by a reversible redox-relay mechanism}, volume = {64}, year = {2025}, }
• (2025). Hydrogen bonding-induced inversion and amplification of circularly polarized luminescence (CPL) in supramolecular assemblies of axially chiral luminogens. ANGEW, 64(18), e202500879. (www)

  @article{ , abstract = {Herein, we report the self-assembly and chiroptical properties of two axially chiral π-conjugated luminogens, R- NMI and S- NMI , each equipped with two pyridyl moieties for hydrogen (H)-bonding with chiral diacids. The two enantiomers display aggregation-induced emission enhancement (AIEE) and increased CD and CPL signals in the self-assembled state with a high g lum value of 1.5 (±0.06)×10 −2 in 1:9 dioxane:methylcyclohexane. Crystallographic analysis confirmed mirror-image helical structures for R -NMI and S -NMI involving both intra- and intermolecular π-π stacking, leading to elongated hexagonal platelets. Supramolecular co-assembly of R- NMI with D - and L -tartaric acids ( D -TA and L -TA ) could remarkably modulate and invert the chiroptical properties of R- NMI , which is unachievable with control chiral monoacids. The co-assembled structures were driven by pyridine-carboxylic acid H-bonding as revealed from the crystal structure analysis, which was also supported by computational studies. Strikingly, R -NMI+ D -TA leads to an exceptionally high fourfold amplification in the g lum value [5.4 (±0.04)×10 −2 ] with an inverted sign, which additionally demonstrates intriguing temperature-dependent switching. In contrast, R -NMI+ L -TA results in a threefold reduction in the g lum value [0.54 (±0.015)×10 −3 ], also with an inverted sign compared to R -NMI alone, establishing a clear strategy for chiral discrimination between the two enantiomers of TA .}, archive = {J_ANGEW}, author = {Sandipan Ghorai and Soumyadip Show and Anindita Das}, doi = {10.1002/anie.202500879}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500879}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen bonding-induced inversion and amplification of circularly polarized luminescence (CPL) in supramolecular assemblies of axially chiral luminogens}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic conversion of polyester-derived alcohol into value-added chemicals by engineering atomically dispersed pd catalyst. ANGEW, 64(18), e202500814. (www)

  @article{ , abstract = {Photoreforming presents a promising strategy for upcycling waste polyester-derived alcohol into valuable chemicals. However, it remains a great challenge due to its low performance and unsatisfactory selectivity toward high-value C 2 products. Here, we report the highly efficient and selective conversion of ethylene glycol (EG, a monomer of polyethylene terephthalate (PET)) to glycolaldehyde using atomically dispersed Pd species supported on TiO 2 catalyst. A glycolaldehyde production rate of 5072 μmol g cat −1 h −1 with a selectivity of 90.0 % and long-term durability can be achieved. Experimental and theoretical results show that Pd single atoms can enhance the photocatalytic activity by enriching the photogenerated holes, which are the dominant species for the selective oxidation of EG to glycolaldehyde. More importantly, the adsorption of EG molecules on the catalysts is significantly promoted, which is subsequently transformed into RO⋅ radicals, a crucial intermediate in producing glycolaldehyde. Additionally, Pd single atoms on TiO 2 enable the reduction of the glycolaldehyde desorption barrier, thereby facilitating high selectivity and inhibiting further oxidation to C 1 products. This work provides new insights into the photocatalytic conversion of polyester wastes by atomic engineering.}, archive = {J_ANGEW}, author = {Wenjing Zhang and Xuewei Hao and Xinlin Liu and Mingyu Chu and Shengming Li and Xuchun Wang and Feng Jiang and Lu Wang and Qiao Zhang and Jinxing Chen and Dingsheng Wang and Muhan Cao}, doi = {10.1002/anie.202500814}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500814}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic conversion of polyester-derived alcohol into value-added chemicals by engineering atomically dispersed pd catalyst}, volume = {64}, year = {2025}, }
• (2025). Self-assembled triple-targeted radiosensitizer enhances hypoxic tumor targeting and radio-immunotherapy efficacy. ANGEW, 64(18), e202500645. (www)

  @article{ , abstract = {Targeted delivery of radiosensitizers and real-time monitoring of hypoxia are crucial for overcoming radiotherapy resistance in hypoxic tumors. Here, we report A-Cy-Ni-RGD, a triple-targeted nitroimidazole (Ni)-linked radiosensitizer that self-assembles into nanoparticles (A-Cy-Ni-RGD NPs) for bimodal near-infrared fluorescence (NIR FL) and photoacoustic (PA) imaging-guided radio-immunotherapy. A-Cy-Ni-RGD NPs specifically accumulate in α v β 3 -positive tumors, where they are hydrolyzed by carboxylesterase to form Cy-Ni-RGD NPs, with enhanced FL at 710 nm and dual PA signals at 680 and 730 nm. Under hypoxic conditions, nitroreductase (NTR) further reduces these NPs, covalently labeling endogenous proteins and increasing NP size. This process partially alleviates aggregation-caused quenching effect, increasing the FL 710 signal and decreasing the PA 730 signal, enabling real-time tracking of tumor-specific delivery and hypoxia. Following low-dose X-ray irradiation (2 Gy), elevated NTR expression promotes further Cy-Ni-RGD NPs reduction, enhancing proteins labeling and causing DNA damage. Moreover, radiosensitization with A-Cy-Ni-RGD NPs triggers robust immunogenic cell death, stimulating antitumor immunity that inhibits tumor growth and metastasis, significantly prolonging survival in mice with orthotopic 4T1 tumors. This work underscores the potential of self-assembling, triple-targeted radiotheranostic agents for improving tumor targeting, imaging, and radiotherapy efficacy in hypoxic tumors.}, archive = {J_ANGEW}, author = {Yuyang Tian and Lian Wang and Ruifang Chen and Yinxin Miao and Yili Liu and Weijing Huang and Leyi Fang and Shaohai Liu and Jiewei Luo and Xiaolian Sun and Yan Zhang and Deju Ye}, doi = {10.1002/anie.202500645}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled triple-targeted radiosensitizer enhances hypoxic tumor targeting and radio-immunotherapy efficacy}, volume = {64}, year = {2025}, }
• (2025). Trade-off between toxicity and efficiency in tin- versus lead-based halide perovskites. ANGEW, 64(18), e202500557. (www)

  @article{ , abstract = {Toxicity remains one of the major challenges that prevent Pb-based halide perovskites from widespread utilization. Ideally, non-toxic alternatives can be identified while still maintaining the superior power conversion efficiency of the Pb-based perovskite solar cells. Using the currently most promising candidate, the Sn-based halide perovskites, as an example, we show that a trade-off exists between toxicity and efficiency in the Sn- versus Pb-based halide perovskites. Indeed, the dominant nonradiative recombination center in the Sn-based halide perovskites differs from the one in its Pb-based counterparts, resulting in the nonradiative capture coefficient in CsSnI 3 being an order of magnitude higher than that in CsPbI 3 . We attribute this difference to the band alignment. Our results indicate that development of halide perovskites beyond the Pb and Sn bases is essential for efficient yet environmentally friendly perovskite solar cells.}, archive = {J_ANGEW}, author = {Xie Zhang and Jimmy-Xuan Shen and Mark E. Turiansky and Chris G. Van de Walle}, doi = {10.1002/anie.202500557}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500557}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Trade-off between toxicity and efficiency in tin- versus lead-based halide perovskites}, volume = {64}, year = {2025}, }
• (2025). Dynamic liquid crystal elastomers for body heat- and sunlight- driven self-sustaining motion via material-structure synergy. ANGEW, 64(18), e202500527. (www)

  @article{ , abstract = {Self-sustained actuators powered by natural, low-energy sources based on liquid crystal elastomers (LCEs) are attractive as they offer high safety, abundant energy availability, and practicality in applications. However, achieving stable self-sustaining motion with low-energy sources requires high actuation strain rates within a narrow temperature range near ambient conditions – a great challenge as LCEs with low nematic-to-isotropic transition temperatures (T ni ) generally exhibit reduced actuation strain and strain rates. To address this, we synthesized a carbon nanotube-doped LCE with a low T ni and reversible Diels–Alder crosslinks, termed DALCE, and readily (re)fabricated it into specific structures (e.g., twisted-and-coiled or bimorph shapes). By leveraging material-structure synergy, we achieved both low T ni and high actuation strain rates, enabling self-rolling, self-breathing and autonomous twisting-untwisting movements powered by ambient/body temperature or natural sunlight. This low-energy, self-sustained actuator design opens new possibilities for LCE-based biomedical applications and naturally powered automatic devices.}, archive = {J_ANGEW}, author = {Qing Liu and Zhi-Chao Jiang and Xue Jiang and Jing Zhao and Ying Zhang and Yue Liu and Jun-Bo Hou and Yao-Yu Xiao and Wei Pu and Yue Zhao}, doi = {10.1002/anie.202500527}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500527}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic liquid crystal elastomers for body heat- and sunlight- driven self-sustaining motion via material-structure synergy}, volume = {64}, year = {2025}, }
• (2025). Direct photopatterning of zeolitic imidazolate frameworks via photoinduced fluorination. ANGEW, 64(18), e202500476. (www)

  @article{ , abstract = {Precise and effective patterning strategies are essential for integrating metal–organic frameworks (MOFs) into microelectronics, photonics, sensors, and other solid-state devices. Direct lithography of MOFs with light and other irradiation sources has emerged as a promising patterning strategy. However, existing direct lithography methods often rely on the irradiation-induced amorphization of the MOFs structures and the breaking of strong covalent bonds in their organic linkers. High-energy sources (such as X-rays or electron beams) and large irradiation doses – conditions unfavorable for scalable patterning – are thus required. Here, we report a photoinduced fluorination chemistry for patterning various zeolitic imidazolate frameworks (ZIFs) under mild UV irradiation. Using UV doses as low as 10 mJ cm −2 , light-sensitive fluorine-containing molecules covalently bond to ZIFs and enhance their stability in water. This creates a water-stability contrast between ZIFs in exposed and unexposed regions, enabling scalable direct photolithography of ZIFs with high resolution (2 μm) on 4-inch wafers and flexible substrates. The patterned ZIFs preserve their original crystallinity and porous properties while gaining increased hydrophobicity. This allows for the demonstration of a water-responsive fluorescent MOFs array with implications in sensing and multicolor information encryption.}, archive = {J_ANGEW}, author = {Xiaoli Tian and Wenjun Li and Fu Li and Mingfeng Cai and Yilong Si and Hao Tang and Haifang Li and Hao Zhang}, doi = {10.1002/anie.202500476}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500476}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct photopatterning of zeolitic imidazolate frameworks via photoinduced fluorination}, volume = {64}, year = {2025}, }
• (2025). Chiral communication between enantiomeric sergeants and achiral soldiers in racemic triblock copolymers with heterochiral cores for triggering multiple helicity inversions. ANGEW, 64(18), e202500444. (www)

  @article{ , abstract = {Amplification of asymmetry in complex supramolecular/polymer system results from the delicate interplay of chiral and achiral structures. Here, a novel approach to the racemic sergeants and soldiers (S&S) effect, using enantiomeric sergeants ( Sgt .) and achiral soldiers ( Sold .), achieves unique precise control over both intensity and sign of global chirality. Chiroptical assemblies of different dimensions in racemic S&S copolymers can be constructed in situ via polymerization-induced chiral self-assembly (PICSA). We systemically investigated chiral communication pathways between chiral-chiral, chiral-achiral, and two oppositely configured azobenzene (Azo) segments, which robustly affect the global chiroptical activity of the racemic S&S assemblies. Chain length-, Sgt./Sold . ratios-, and temperature-dependent CD/UV/Vis, small-angle X-ray scattering (SAXS), wide-angle X-ray diffraction (WAXD), differential scanning calorimetry (DSC) and polarized optical microscopy (POM) results provided insights into the kinetics for chiroptical inversions. LC phase transitions, the helical preferences of the Sgt . and Sold . units, and the stability of the “chiral core” allow racemic S&S copolymer assemblies to exhibit chiral conflict between heterochiral blocks in an enantioselective fashion.}, archive = {J_ANGEW}, author = {Zixiang He and Haotian Ma and Zeyu Tang and Xiaoxiao Cheng and Wei Zhang}, doi = {10.1002/anie.202500444}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral communication between enantiomeric sergeants and achiral soldiers in racemic triblock copolymers with heterochiral cores for triggering multiple helicity inversions}, volume = {64}, year = {2025}, }
• (2025). GOAT: A global optimization algorithm for molecules and atomic clusters. ANGEW, 64(18), e202500393. (www)

  @article{ , abstract = {In this work, we propose a new Global Optimization Algorithm (GOAT) for molecules and clusters of atoms and show how it can find the global energy minima for both systems without resorting to molecular dynamics (MD). This avoids the potential millions of time-consuming gradient calculations required by a long MD run. Because of that, it can be used with any regular quantum chemical method, even with the costlier hybrid DFT. We showcase its accuracy by running it on various systems, from organic molecules to water clusters, metal complexes, and metal nanoparticles, comparing it with state-of-the-art methods such as the Conformer-Rotamer Ensemble Sampling Tool (CREST). We also discuss its underlying theory and mechanisms for succeeding in challenging cases. GOAT is, in general, more efficient and accurate than previous algorithms in finding global minima and succeeds in cases where others cannot due to the free choice for the Potential Energy Surface (PES).}, archive = {J_ANGEW}, author = {Bernardo de Souza}, doi = {10.1002/anie.202500393}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500393}, shortjournal = {Angew. Chem. Int. Edit.}, title = {GOAT: A global optimization algorithm for molecules and atomic clusters}, volume = {64}, year = {2025}, }
• (2025). Water-stable 2-pyridylboron reagents: Pd-catalyzed 2-pyridylation reaction of aryl halides. ANGEW, 64(18), e202500315. (www)

  @article{ , abstract = {The stability of 2-pyridylation reagents is a long-standing issue in cross-coupling chemistry due to hydrolysis. However, as the use of pyridine-based pharmaceuticals continues to increase, there is a high demand for stable and reactive 2-pyridylation reagents. Herein, a general strategy to prepare water-stable 2-pyridylboron reagents has been developed. The application of the water-stable 2-pyridylboron reagents in a neutral Suzuki–Miyaura coupling with a halide scavenger enables an efficient 2-pyridylation reaction of aryl halides.}, archive = {J_ANGEW}, author = {Wei Li and Yu Chen and Ruyi Yuan and Xuhao Jia and Yingming Yao and Li Zhang}, doi = {10.1002/anie.202500315}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500315}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Water-stable 2-pyridylboron reagents: Pd-catalyzed 2-pyridylation reaction of aryl halides}, volume = {64}, year = {2025}, }
• (2025). Tandem assembly and etching chemistry towards mesoporous conductive Metal–Organic frameworks for sodium storage over 50,000 cycles. ANGEW, 64(18), e202500287. (www)

  @article{ , abstract = {Despite two-dimensional (2D) conductive metal–organic frameworks (cMOFs) being attractive due to their intrinsic electrical conductivity and redox activity for energy applications, alleviating the constrained mass transfer within long-range micropore channels remains a significant challenge. Herein, we present a tandem assembly and etching chemistry, to incorporate perpendicularly aligned mesopores into the micropores of cMOFs, via a bi-functional modulator. Synchrotron spectral and morphological analyses demonstrate that the elaborate ammonia modulator first coordinates with Zn 2+ forming defects during the initial self-assembly of cMOF oligomers, which then initiates mesoporous cMOFs via in situ etching. In situ spectroscopy and theoretical simulations further reveal that such a unique perpendicular mesoporous structure shorts the micropore channels by two orders of magnitude and relaxes the inherent ion stacking within micropores, leading to five times faster Na + transport and a remarkable rate capability at 250 C and sodium storage lifespan over 50,000 cycles. Our protocol opens up a new avenue for introducing mesopores into microporous cMOFs for advanced energy applications and beyond.}, archive = {J_ANGEW}, author = {Jiahao Chen and Gaoyang Li and Fanxing Bu and Jiazhuang Tian and Lin Liu and Yifeng Wang and Jie Zhang and Xingjin Li and Xiang Li and Zhuo Yang and Dongliang Chao and Dongyuan Zhao}, doi = {10.1002/anie.202500287}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500287}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem assembly and etching chemistry towards mesoporous conductive Metal–Organic frameworks for sodium storage over 50,000 cycles}, volume = {64}, year = {2025}, }
• (2025). High-connectivity 3D covalent organic frameworks with pdp net for efficient C2H2/CO2 separation. ANGEW, 64(18), e202500161. (www)

  @article{ , abstract = {High-connectivity 3D covalent organic frameworks (COFs) have garnered significant attention due to their structural complexity, stability, and potential for functional applications. However, the synthesis of 3D COFs using mixed high-nodal building units remains a substantial challenge. In this work, we introduce two novel 3D COFs, JUC-661 and JUC-662, which are constructed using a combination of D 2h -symmetric 8-nodal and D 3h -symmetric 6-nodal building blocks. These COFs feature an unprecedented [8+6]-c pdp net with rare mesoporous polyhedral cages (~3.9 nm). Remarkably, JUC-661 and JUC-662 exhibit outstanding separation capabilities, achieving adsorption selectivities of 4.3 and 5.9, respectively, for C 2 H 2 /CO 2 (1/1, v/v) mixtures. Dynamic breakthrough experiments confirm their excellent separation capability, maintaining this performance even under conditions of 100 % humidity. Monte Carlo simulations and DFT calculations indicate that the exceptional adsorption performance is attributed to the well-defined pore cavities of the COFs, with fluorination of the building unit further enhancing C 2 H 2 selectivity through improved electrostatic and host–guest interactions. This study expands the structural diversity of COFs and highlights their potential for low-energy separation processes.}, archive = {J_ANGEW}, author = {Jie Zhang and Haorui Zheng and Fengqian Chen and Zitao Wang and Hui Li and Fuxing Sun and Dan Zhao and Valentin Valtchev and Shilun Qiu and Qianrong Fang}, doi = {10.1002/anie.202500161}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-connectivity 3D covalent organic frameworks with pdp net for efficient C2H2/CO2 separation}, volume = {64}, year = {2025}, }
• (2025). Ring expansion via palladium-catalyzed aryne insertion into C−C bonds of benzocyclobutenones. ANGEW, 64(18), e202500148. (www)

  @article{ , abstract = {Insertion of arynes into cyclic C−C bonds provides a straightforward approach for ring expansion with an ortho -phenylene moiety; however, the current scope of substrates has been restricted to enolizable ketones. Here we report the first example of aryne-insertion into non-enolizable ketones through Pd-catalyzed C−C bond activation of benzocyclobutenones. 2-Haloaryl boronates were employed as an unconventional aryne precursor. The reaction shows a wide substrate scope and high functional group tolerance. The mechanistic studies reveal an interesting dual role of the Pd catalyst for both aryne generation and C−C bond activation.}, archive = {J_ANGEW}, author = {Cole J. Wagner and Guangbin Dong}, doi = {10.1002/anie.202500148}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500148}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ring expansion via palladium-catalyzed aryne insertion into C−C bonds of benzocyclobutenones}, volume = {64}, year = {2025}, }
• (2025). Regiodivergent and enantioselective allylic C−H alkylation of allyl ethers: Optimization, scope, mechanism and application. ANGEW, 64(18), e202500125. (www)

  @article{ , abstract = {Vinyl ethers and allyl ethers are important motifs in natural products and pharmaceuticals. Among various methods toward their synthesis, direct allylic C−H functionalization of allyl ethers is one of the most efficient approaches. In this study, one of two regioisomers, a vinyl ether or an allyl ether, could be obtained, depending on whether a Lewis acid co-catalyst was present. Furthermore, branched allyl ethers were smoothly prepared in excellent regio- and enantioselectivity (up to 20 : 1 b / l , 99 % ee) by synergistic catalysis with an achiral Pd(0) complex and a chiral Lewis acid catalyst.}, archive = {J_ANGEW}, author = {Hongkai Wang and Lijuan Song and Jing Huang and Fule Wu and Zhuang Yang and Yangbin Liu and Yun-Dong Wu and Xiaoming Feng}, doi = {10.1002/anie.202500125}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500125}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regiodivergent and enantioselective allylic C−H alkylation of allyl ethers: Optimization, scope, mechanism and application}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of the marine diterpenoids caucanolide e and f by alkyne gem-hydrogenation: Rigorous reassignment of two almost indistinguishable diastereomers. ANGEW, 64(18), e202500124. (www)

  @article{ , abstract = {As the spectra of the diastereomeric marine seco -cembranoids caucanolide E and F are almost identical, the isolation team had not been able to firmly assign their stereostructure. The puzzle has now been solved by a synthetic approach predicated on biogenetic considerations, which suggested that both natural products are 10 S configured but differ in the configuration of their C8 stereocenter. Under this proviso, they can be distinguished by comparison with synthetic samples that are deliberately 8 S ,10 S and 8 S ,10 R configured: only one natural product can match sign and magnitude of the [α] D of one of these reference compounds; this particular caucanolide must be the 8 S ,10 S isomer. Both reference compounds needed for this benchmarking exercise were accessible from a single precursor via ruthenium catalyzed gem -hydrogenation of an enyne to furnish an alkoxyfuran in the first place, followed by hydrolysis; this key transformation leverages the electrophilic character of the pianostool ruthenium carbene intermediates passed through. The recorded data showed that the assignment proposed in the literature is incorrect and needs to be reversed; this conclusion was independently confirmed by a combined NMR/DFT approach using a CP3 probability analysis.}, archive = {J_ANGEW}, author = {Ricardo Molina Betancourt and Markus Leutzsch and Alois Fürstner}, doi = {10.1002/anie.202500124}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500124}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of the marine diterpenoids caucanolide e and f by alkyne gem-hydrogenation: Rigorous reassignment of two almost indistinguishable diastereomers}, volume = {64}, year = {2025}, }
• (2025). Selective gold recycling from electronic waste using a highly stable porous aromatic Framework/Polymer and its application for CO2 electroreduction. ANGEW, 64(18), e202500092. (www)

  @article{ , abstract = {Recycling gold from electronic waste represents a sustainable and environmentally friendly strategy for both resource recovery and waste reduction. In this study, we designed an innovative and highly stable porous aromatic framework (PAF)/polymer composite, PAF-147/polydopamine (PDA), as an efficient adsorbent for selective gold recovery for the first time. The maximum gold adsorption capacity of PAF-147/PDA reached 1700 mg g −1 . Furthermore, it could rapidly extract over 95 % of gold from solutions in a pH range of 0–10 within just 2 minutes. Importantly, as a real application demonstration, the PAF-147/PDA composite selectively recovered 99 % of gold from the leachate of discarded central processing units. When the recovered Au-containing composite was applied to electrocatalytic CO 2 reduction, the Faradaic efficiency for CO production exceeded 95 % across acidic, neutral, and alkaline electrolytes, outperforming most reported gold-based catalysts due to the cooperation effect of the composite and Au. This work opens a new way for the combination of selective gold recovery from electronic waste with highly efficient CO 2 conversion.}, archive = {J_ANGEW}, author = {Tianwei Xue and Guangkuo Xu and Chengbin Liu and Ruiqing Li and Yanyin Wu and Yuyu Guo and Shan Gong and Zeyu Shao and Xiangcheng Cai and Haoyu Zou and Linxiao Cui and Jia Zhao and Zhihong Gao and Shuliang Yang and Jun Li and Buxing Han and Li Peng}, doi = {10.1002/anie.202500092}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective gold recycling from electronic waste using a highly stable porous aromatic Framework/Polymer and its application for CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Manipulating σ-hole interactions in halogenated additives for high-performance organic solar cells with 19.8 % efficiency. ANGEW, 64(18), e202500085. (www)

  @article{ , abstract = {The incorporation of volatile solid additives has emerged as an effective strategy for enhancing the performance of organic solar cells (OSCs). However, the influence of the electronic structure of these additives on morphological evolution remains insufficiently understood. Herein, 1,4-Dibromobenzene (DBB) and 1,4-Difluoro-2,5-dibromobenzene (DFBB) are introduced as volatile additives into OSCs. Theoretical calculations indicate that DFBB has a higher electrostatic potential extremum and stronger σ-holes interaction compared to DBB, enabling more robust intermolecular interactions with acceptors. The synergistic halogen interactions between DFBB and the active layer matrix balances the differences in crystallinity between the donor and acceptor during the film formation process, promotes the formation of dense molecular packing and ordered orientation, optimizes the vertical composition distribution, and promotes the formation of domain sizes close to the exciton diffusion distance. Consequently, the PM6 : L8-BO-based device treated with DFBB achieves an efficiency of 19.2 % with a fill factor (FF) of 80.8 %, which is superior to the control and DBB. Further validation across various systems, including PM6 : Y6, PM6 : BTP-eC9, and D18 : L8-BO, highlights similar efficiency enhancements, with the D18 : L8-BO system achieving an outstanding PCE of 19.8 %. This work demonstrates that the modulation of σ-hole interactions in volatile additives can effectively optimize multi-scale morphology for high-performance OSCs.}, archive = {J_ANGEW}, author = {Wenzhao Xiong and Yongjie Cui and Ziyue Zhang and Shenbo Zhu and Zhibo Wang and Zhaohan Chai and Huawei Hu and Yiwang Chen}, doi = {10.1002/anie.202500085}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating σ-hole interactions in halogenated additives for high-performance organic solar cells with 19.8 % efficiency}, volume = {64}, year = {2025}, }
• (2025). Data-driven accelerated discovery coupled with precise synthesis of single-atom catalysts for robust and efficient water purification. ANGEW, 64(18), e202500004. (www)

  @article{ , abstract = {The development of advanced catalysts frequently employs trial-and-error methods and is lack of highly controlled synthesis, resulting in unsatisfactory development efficiency and performance. Here we propose a data-driven prediction coupled with precise synthesis strategy to accelerate the development of single-atom catalysts (SACs) for efficient water purification. The data-driven approach enables the rapid screening and prediction of high-performance SACs from 43 metals-N 4 structures comprising transition and main group metal elements, followed by validation and structural modulation for improved performance through a highly controllable hard-template method. Impressively, a well-designed Fe-SAC with a high loading of Fe-pyridine-N 4 sites (~3.83 wt %) and highly mesoporous structure, exhibits ultra-high decontamination performance (rate constant of 100.97 min −1 g −2 ), representing the best Fenton-like activities for sulfonamide antibiotics to date. Furthermore, the optimized Fe-SAC shows excellent robust environmental resistance and cyclic stability with almost 100 % degradation efficiency of sulfonamide antibiotics for 100-h continuous operation. Density functional theory calculations reveal that Fe-pyridine-N 4 sites can reduce the energy barrier of intermediate O* formation, the rate-determining step, resulting in highly selective generation of singlet oxygen. The integration of data-driven method with precise synthesis strategy provides a novel paradigm for the rapid development of high-performance catalysts for environmental field as well as other important fields including sustainable energy and catalysis.}, archive = {J_ANGEW}, author = {Keng-Qiang Zhong and Fu-Yun Yu and Di Zhang and Zheng-Hao Li and Dong-Hua Xie and Ting-Ting Li and Yun Zhang and Li Yuan and Hao Li and Zhen-Yu Wu and Guo-Ping Sheng}, doi = {10.1002/anie.202500004}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202500004}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Data-driven accelerated discovery coupled with precise synthesis of single-atom catalysts for robust and efficient water purification}, volume = {64}, year = {2025}, }
• (2025). Terpyridine- and quarterpyridine-based cationic covalent organic frameworks for visible-light-catalytic H2O2 synthesis. ANGEW, 64(18), e202425617. (www)

  @article{ , abstract = {This paper presents multipyridine-containing covalent organic frameworks (COFs) with precisely defined position and number of pyridinium cationic groups. Specifically, three terpyridine- and quarterpyridine-based trialdehydes were synthesized, and utilized as the starting monomers to polymerize with trimethylpyridinium bromide to yield vinylene-linked iTPy-COF, iTPPy-COF and iQPPy-COF, respectively. Thus constructed donor-acceptor cationic COFs exhibit considerably high visible-light catalytic efficiency for hydrogen peroxide (H 2 O 2 ) synthesis by the dual-channel mechanisms of oxygen reduction reaction (ORR) and water oxidation reaction (WOR). In pure water and O 2 atmosphere, the H 2 O 2 production rate (HPR) of iTPPy-COF after 1 h reaction is as high as 7955 μmol g −1 h −1 . Even though in air, its HPR value still reaches 6249 μmol g −1 h −1 . Moreover, it is found that changing the arm lengths and ratios of pyridine to benzene ring in the frameworks significantly affects the photocatalytic capability. The structure–property relationship is investigated in terms of the variations of electronic structures through the theoretical simulations and measurements of photophysical parameters such as fluorescence lifetimes, photocurrent intensities, and impedances of charge transfer, which offers new insights into the engineering of multipyridine-based cationic COFs for highly efficient H 2 O 2 photosynthesis.}, archive = {J_ANGEW}, author = {Jun Zhang and Fei Xue and Zhonggang Wang}, doi = {10.1002/anie.202425617}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202425617}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Terpyridine- and quarterpyridine-based cationic covalent organic frameworks for visible-light-catalytic H2O2 synthesis}, volume = {64}, year = {2025}, }
• (2025). Novel low-cytotoxic and highly efficient type i photoinitiators for visible LED-/Sunlight-induced photopolymerization and high-precision 3D printing. ANGEW, 64(18), e202425598. (www)

  @article{ , abstract = {The development of photoinitiators (PIs) combining high initiation ability, low-toxicity, and availability for high-precision 3D printing is a key challenge and an urgent problem to be solved nowadays in photopolymerization. In this study, carbazole chalcone glyoxylate oxime ester derivatives (denoted as Cs, C1−C5) containing both glyoxylate and oxime ester moieties with good light absorption properties in the visible range have been designed as type I PIs for the free radical photopolymerization (FRP) of trimethylolpropane triacrylate (TMPTA) and ethoxylated trimethylolpropane triacrylate (ETPTA) under 405 nm and 450 nm light-emitting diodes (LEDs) as well as sunlight irradiation. The reaction properties and mechanism of Cs are firstly predicted by molecular modeling/molecular design, which anticipate that C5 could exhibit the best photoinitiation ability, this structure being more prone to decarboxylation. Subsequent experimental results clearly show that the photoinitiation ability of C5 outperforms that of the benchmark commercial PIs (methyl benzoylformate (MBF), diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO)), and phenylbis (2,4,6-trimethylbenzoyl)-phosphine oxide (BAPO) under the same conditions. Compared to TPO, the photoinitiation ability of C5 improved by 40 %, 132 %, and 47 % exposed to LED@405 nm, LED@450 nm, and sunlight. In addition, C5 is successfully applied to 3D printing for the manufacture of large-scale and high-resolution object. The photochemical mechanism of C5 is systematically and comprehensively analyzed using a combination of steady state photolysis, decarboxylation reaction, fluorescence experiments, and electron spin resonance-spin trapping (ESR-ST) technology. It is found that both glyoxylate and oxime ester in C5 are highly active and capable of undergoing decarboxylation reactions to produce CO 2 and free radicals, which is consistent with the results predicted by molecular modeling. Furthermore, the low-toxicity of C5 is evidenced by cytotoxicity assays. The comprehensive molecular modeling and experimental approach adopted in this research has led to the development of novel PIs that are highly efficient and low-toxic, and can be used for high-precision 3D printing, which offers broad application prospects in the fields of environmental sustainability, visible light curing, and biomedical science.}, archive = {J_ANGEW}, author = {Tong Gao and Zheng Liu and Jiansong Yin and Ji Feng and Céline Dietlin and Fabrice Morlet-Savary and Michael Schmitt and Tatiana Petithory and Laurent Pieuchot and Jing Zhang and Frédéric Dumur and Jacques Lalevée and Pu Xiao}, doi = {10.1002/anie.202425598}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202425598}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Novel low-cytotoxic and highly efficient type i photoinitiators for visible LED-/Sunlight-induced photopolymerization and high-precision 3D printing}, volume = {64}, year = {2025}, }
• (2025). Water in electrocatalysis. ANGEW, 64(18), e202425590. (www)

  @article{ , abstract = {Renewable electricity-powered electrocatalysis technologies occupy a central position in clean energy conversion and the pursuit of a net-zero carbon emission future. Water can serve multiple roles in electrocatalytic reactions, for instance, as a reaction medium, reactant, modifier, promoter, etc. This significantly influences the mass transport, active site, intermediate adsorption and reaction kinetics, ultimately determining the electrocatalytic performance (e.g., activity, selectivity, and stability) as well as device efficiency. As the heart location where electrocatalytic reactions occur, the typical electrical-double layer is established at a water-electrode interface. Therefore, the comprehension and regulation of water are crucial topics in electrocatalysis, which encourages us to organize this review. We begin with the fundamental understanding on structure of water and its behavior under electrochemical conditions. Subsequently, we delve into the “water effect” by elucidating specific functions of water in electrocatalysis. Recent advances in manipulating water to enhance electrocatalytic efficiency of representative reactions such as hydrogen evolution/oxidation, oxygen evolution/reduction, CO 2 reduction, N 2 reduction and organic electrosynthesis, are also highlighted. We finally discuss the remaining challenges and future opportunities in this field.}, archive = {J_ANGEW}, author = {Yuliang Yuan and Jin Li and Yiting Zhu and Yan Qiao and Zhenye Kang and Zhitong Wang and Xinlong Tian and Hongwen Huang and Wenchuan Lai}, doi = {10.1002/anie.202425590}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202425590}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Water in electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Pathway engineering in pd-based supramolecular cage synthesis via inner-outer steric synergy. ANGEW, 64(18), e202425369. (www)

  @article{ , abstract = {For artificial supramolecular architectures designed to mimic biological systems, achieving different pathway synthesis is challenging due to the requirement of multiple stable and interconvertible intermediates. Here, we propose a novel “inner-outer steric synergy” strategy and investigate controllable pathway engineering for the synthesis of specific structures. Firstly, three structures ( Ring - Pd 2 L A 2 , Bowl - Pd 2 L A 3 and Cage - Pd 2 L A 4 ) with interconversion properties were selectively formed by assembling externally modified ligand L A with Pd(II). Furthermore, Ring-Pd 2 L A 2 can further assemble with the ligand L B with inner steric hindrance to generate heteroleptic trans -Pd 2 L A 2 L B 2 cage, while Bowl-Pd 2 L A 3 , as an intermediate, can assemble with L B to form Pd 2 L A 3 L B . It is noteworthy that Ring-Pd 2 L A 2 , Bowl-Pd 2 L A 3 , and Cage-Pd 2 L A 4 can interconvert under specific conditions, enabling the synthesis of Pd 2 L A 3 L B and trans -Pd 2 L A 2 L B 2 through 10 and 16 pathways, respectively. This research not only introduces a novel strategy for constructing heteroleptic cages but also demonstrates the achievement of pathway engineering.}, archive = {J_ANGEW}, author = {Ziteng Guo and Hao Yu and Junjuan Shi and Ningxu Han and Guanglu Wu and Houyu Zhang and Bingling Li and Ming Wang}, doi = {10.1002/anie.202425369}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202425369}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pathway engineering in pd-based supramolecular cage synthesis via inner-outer steric synergy}, volume = {64}, year = {2025}, }
• (2025). Super-concentrated alkali hydroxide electrolytes for rechargeable zn batteries. ANGEW, 64(18), e202425261. (www)

  @article{ , abstract = {Increasing the salt concentration of an electrolyte to over 10 M brings new solute-solvent interactions that define an emerging class of super-concentrated electrolytes for rechargeable batteries. To this class we introduce a super-concentrated alkaline electrolyte. Nearly saturated with KOH (at 15 M), the aqueous solution displays a broad electrochemical stability window (>2.5 V on Au) while retaining an exceptionally high ionic conductivity (>0.27 S/cm at 25 °C). Without a solid-electrolyte interphase, we can confirm the role of electron transfer kinetics in determining the stability as opposed to the thermodyanmic effect computed based on activity coefficients. The compositionally simple solution also allows spectroscopies and ab-initio molecular dynamics simulation to identify a novel mechanism of OH − structural diffusion, where unlike the conventional Grotthuss mechanism through hydrogen-bond networks, electrostatic forces sustain proton hopping and break the common stability-conductivity tradeoff. A high ZnO solubility in the electrolyte further mitigate the issue of passivation when a Zn anode is deeply discharged. These unique properties enable a NiOOH||Zn battery to deliver a cumulative capacity >10 Ah/cm 2 at 40 mA/cm 2 to meet practical needs of safe, inexpensive energy storage.}, archive = {J_ANGEW}, author = {Yilin Ma and Jiajia Huang and Shengyong Gao and Liangyu Li and Zhibin Yi and Diwen Xiao and Cheuk Kai Kevin Chan and Bin Wang and Ding Pan and Qing Chen}, doi = {10.1002/anie.202425261}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202425261}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Super-concentrated alkali hydroxide electrolytes for rechargeable zn batteries}, volume = {64}, year = {2025}, }
• (2025). Can electroactive tracer molecules reveal viscoelastic structure by measuring non-fickian diffusion?. ANGEW, 64(18), e202425114. (www)

  @article{ , abstract = {We find that viscous and viscoelastic fluids are distinguishable by gauging Non-Fickian diffusion of dissolved electroactive molecules. Typically, such fluids are differentiated by measuring the mean-squared-displacement <Δ r 2 > of embedded tracer particles (~1 μm) diffusing over time ( t ). From the relationship <Δ r 2 >=6D t α ( D =particle diffusivity), log plots of <Δ r 2 >vs. t α reveal regimes encoded in the slope α . For Fickian diffusion α =1, whereas α <1 and α >1, indicate Non-Fickian sub- and super-diffusion, respectively. Here, we electrolyzed redox reporters as molecular tracers in selected fluids. The current ( I ) relationship I v 1/2 ( v =scan-rate) was recast as I 2 vs.1/ t α to introduce α as Non-Fickian quantifier in log plots. When viscosity increased at high concentration of small-molecules, D for the redox reporter declined but α remained constant at ~1 (Fickian). In contrast, both D and α (<1) decreased in viscoelastic hydrogels confirming a molecular sub-diffusive regime. These results agree with particle microrheology on the same fluid types using optical methods that are inapplicable to molecules. By quantifying Non-Fickian diffusion of electroactive molecular tracers, our method can uncover diffusion-structure relationships to identify regulators in neurodegenerative liquid-solid transitions of protein aggregates. Unlike tracer particles, the diffusivity of tracer molecules is controlled by the applied potential and electrode size.}, archive = {J_ANGEW}, author = {Lei Wu and Alfonso Ramirez and Ivy D. Vo and Ellinor Haglund and Julio C. Alvarez}, doi = {10.1002/anie.202425114}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202425114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Can electroactive tracer molecules reveal viscoelastic structure by measuring non-fickian diffusion?}, volume = {64}, year = {2025}, }
• (2025). Integration of through-space conjugation of an adjacent arene with a Nitrogen/Carbonyl framework for narrowband emission. ANGEW, 64(18), e202424950. (www)

  @article{ , abstract = {Organic luminescent materials featuring noncovalent through-space conjugation (TSC) have attracted considerable attention. However, the presence of multiple vibrational energy levels and weak spatial electron delocalization typically results in broad emission peaks for TSC-based emitters, significantly impeding their extensive application in optoelectronic technologies. Herein, two TSC emitters, TSFQ-TRZ and TSFQ-Ph , were synthesized by integrating a fused nitrogen/carbonyl skeleton with various adjacent arene 2,4,6-triphenyl-1,3,5-triazine (TPTRZ) and phenyl group segments through a rigid spiro spacer. These emitters exhibited narrow emissions, with full widths at half-maximum of 19 nm and 25 nm, respectively. Experimental and theoretical investigations unveiled that the TPTRZ segment introduces steric hindrance, while simultaneously suppressing molecular vibrations through intramolecular interactions—a key factor in achieving narrow emissions. Leveraging this narrow blue emission, electroluminescent devices employing TSFQ-TRZ as the emitter achieved an impressive maximum external quantum efficiency of 26.7 %, which further increased to 28.3 % when sensitized by phosphorescent emitter. This work demonstrates highly efficient, narrowband emissions from TSC-based emitters, thereby expanding their potential applications in the electroluminescence field.}, archive = {J_ANGEW}, author = {Rui-Hong Liu and Zi-Qi Feng and Shi-Jie Ge and Yu Wang and Zhe-Hong Yu and Jian-Rong Wu and Hong-Yan Yan and Dong-Ying Zhou and Liang-Sheng Liao and Zuo-Quan Jiang}, doi = {10.1002/anie.202424950}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424950}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integration of through-space conjugation of an adjacent arene with a Nitrogen/Carbonyl framework for narrowband emission}, volume = {64}, year = {2025}, }
• (2025). Maximizing the accessibility of acid sites within zeolite catalysts for syngas conversion. ANGEW, 64(18), e202424946. (www)

  @article{ , abstract = {Mass transport within zeolites is pivotal in determining the accessibility of active sites to reactants and hence the catalytic performance. However, there lacks of quantitative guidance for synthesis of desired zeolites with reduced diffusion limitation. Herein, we take mordenite (MOR) zeolite as a model, which is characterized by 12-membered rings (MR) channels as transport path towards the active sites within the 8MR side pockets for syngas conversion to light olefins. By correlating the effective diffusion lengths ( ) with the Thiele modulus and the effectiveness factors of reaction rates over a composite catalyst ZnAlO x -MOR, we determine that the shortest 12MR channel length ( ) of 60 nm in this study is close to the threshold length necessary for full access to the 8MR acid sites. As a result, it exhibits excellent catalytic performance with CO conversion reaching 33 % and ethylene selectivity 69 %. Furthermore, the methodology is general and essential for further development of efficient zeolite catalysts with fully accessible active sites.}, archive = {J_ANGEW}, author = {Haodi Wang and Feng Jiao and Jingyao Feng and Yinchan Zhang and Zhaochao Xu and Xiulian Pan and Xinhe Bao}, doi = {10.1002/anie.202424946}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424946}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Maximizing the accessibility of acid sites within zeolite catalysts for syngas conversion}, volume = {64}, year = {2025}, }
• (2025). Synthetic approaches to molecule-2D transition metal dichalcogenide heterostructures. ANGEW, 64(18), e202424932. (www)

  @article{ , abstract = {The integration of 2D materials with molecular chemistry to create molecule-2D material heterostructures presents a compelling strategy for advancing material design and applications. This approach provides precise control over the structure and properties of 2D materials, effectively addressing challenges in their production and fabrication. Among these, molecule-2D transition metal dichalcogenide (mTMD) heterostructures have garnered significant attention due to their distinctive electronic, optical, and catalytic properties, as well as the intriguing emergent states and phenomena resulting from interactions with adjacent molecular and material layers. Achieving the desired electronic and optical properties in these heterostructures hinges on carefully controlling the interactions at the molecule/TMD interfaces. This minireview highlights recent progress in mTMD heterostructures, emphasizing the principles underlying interface interactions, molecular arrangement, and innovative synthetic methodologies.}, archive = {J_ANGEW}, author = {Sofiia Zuieva and Xin Chen}, doi = {10.1002/anie.202424932}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthetic approaches to molecule-2D transition metal dichalcogenide heterostructures}, volume = {64}, year = {2025}, }
• (2025). Discovery of covalent and cell-active ALKBH5 inhibitors with potent antileukemia effects in vivo. ANGEW, 64(18), e202424928. (www)

  @article{ , abstract = {The N 6 -methyladenosine (m 6 A) demethylase ALKBH5 is the only other identified m 6 A eraser except for FTO, and dysregulated ALKBH5 functions were closely associated with leukemogenesis. However, the development of ALKBH5 inhibitors is slow compared to FTO inhibitors. Inspired by a non-catalytic C200-covalent strategy, a series of maleimide derivatives were designed and synthesized as potent and covalent ALKBH5 inhibitors in this work. The analog 18 l exhibited excellent inhibitory effects on ALKBH5 (IC 50 =0.62 μM), and exerted a strong antiproliferative effect on NB4 cells with IC 50 of 0.63 μM. The K d value of 18 l binding to ALKBH5 was 804 nM, while no binding was observed with FTO. This result indicated that 18 l was a highly selective inhibitor of ALKBH5 rather than FTO. Additionally, proteomic experiments showed that 18 l directly targeted ALKBH5 in cells and altered m 6 A levels on mRNA, blocked the related downstream signal pathways, promoted differentiation, and induced apoptosis. Furthermore, 18 l exerted excellent in vivo antitumor activity with TGI TV values of 66.3 % at 1 mg/kg in NB4 tumor xenograft models.}, archive = {J_ANGEW}, author = {Hengbo Wu and Gan-Qiang Lai and Ruixiang Cheng and Hui Huang and Ju Wang and Zeyu Liu and Jing Gao and Hu Zhou and Chunpu Li and Cai-Guang Yang and Hong Liu}, doi = {10.1002/anie.202424928}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424928}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Discovery of covalent and cell-active ALKBH5 inhibitors with potent antileukemia effects in vivo}, volume = {64}, year = {2025}, }
• (2025). Tandem switch-triggered on-demand synthesis of aromatic amines in high yields. ANGEW, 64(18), e202424847. (www)

  @article{ , abstract = {Tandem catalysis stands as a beacon of chemical sustainability. Although bifunctional catalysts have achieved wide success in two-step tandem reactions, achieving multi-step catalysis with three or more distinct and potentially incompatible catalytic sites and components remains an ambitious challenge. Here, we present a “tandem switch” strategy that transforms these incompatibilities into functional advantages, enabling on-demand production of primary, secondary, and tertiary aromatic amines, all with yields exceeding 96 %. A kinetic switch, enabled by phosphotungstic acid functionalization of the Ni−Ni(Al)O heterojunction catalyst, modulates the Ni−Ni and Ni−O boundary microenvironment to simultaneously accelerate the rate-determining steps in nitrobenzene hydrogenation, N-alkylation, and aza-Michael addition. Meanwhile, a thermodynamic switch, controlled by the competitive adsorption of ethanol, hydrogen, and acrylonitrile, stepwise minimizes Gibbs free energy to ensure a seamless reaction cascade. Hence, by toggling these tandem switches on or off, we achieve selective regulation of nitrobenzene conversion pathways into the production of targeted aromatic amine. Techno-economic analysis shows the developed process significantly reduces material and energy consumption for sustainable amine production.}, archive = {J_ANGEW}, author = {Zhou Chen and Keng Sang and Lei Ye and Jian Zhang and Xinyue Wang and Wenyao Chen and Gang Qian and Jing Zhang and Jichang Liu and Xinggui Zhou and Jing He and De Chen and Weikang Yuan and Xuezhi Duan}, doi = {10.1002/anie.202424847}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem switch-triggered on-demand synthesis of aromatic amines in high yields}, volume = {64}, year = {2025}, }
• (2025). Dominant face-on oriented perylene-diimide interlayers for high-performance organic solar cells. ANGEW, 64(18), e202424502. (www)

  @article{ , abstract = {Electron transport properties of cathode interlayers are crucial to high-performance organic solar cells (OSCs). We propose a novel approach to enhance electron transport of cathode interlayers through controlling a preferential face-on molecular orientation of non-ionic perylene-diimide- (PDI) based cathode interlayers with restricted n-doping effects. 1-(2,5,8-trioxadec-10-yl)-1,2,3-triazole (TOT) units as bulky and extended side chains were incorporated into brominated-PDIs via click chemistry to yield PDIBr-TOT. TOT side chains impart PDI-based interlayers with a dominant face-on orientation, meanwhile leading to a negligible doping effect due to their weak electron-donating properties. Impressively, at a slight doping level, higher electron mobility is gained through efficient vertical charge transport channels built by preferred face-on molecular orientations of PDIBr-TOT, beating the results acquired through strong doping effects of traditional PDIBr−N with an edge-on orientation. Thus, PDIBr-TOT can suppress exciton recombination and lower the surface energies for good contact with active layers, consequently leading to increases in fill factor and short-circuit current. Integrating PDIBr-TOT with various active layers, a remarkable efficiency of 19.52 % is obtained. Moreover, device stability is enhanced by restrained doping effects. Modulating face-on orientations of cathode interlayers prescribed here will encourage further innovative designs of high-performance cathode interlayers towards OSC advances.}, archive = {J_ANGEW}, author = {Zhihui Chen and Qi Li and Huijun Tang and Junjie Wen and Yanyi Zhong and Jiangbin Zhang and Kai Han and Yao Liu}, doi = {10.1002/anie.202424502}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dominant face-on oriented perylene-diimide interlayers for high-performance organic solar cells}, volume = {64}, year = {2025}, }
• (2025). A sequential release micro-nano system for colitis therapy via gut microbiota and immune regulation. ANGEW, 64(18), e202424409. (www)

  @article{ , abstract = {Commencing with the breakdown of the intestinal barrier, various pathogenic factors, such as dysbiosis of the gut microbiota, harmful inflammatory cytokines, and immune system imbalance, collectively contribute to the development of colitis. Numerous interventions focusing on single factors have been developed to provide short-term therapeutic benefits, but the continued existence of unresolved pathogenic factors can lead to disease exacerbation. Here we have designed a multicomponent system-inulin microspheres encapsulating selenium-containing nanomicelles, aiming to tackle the multiple factors associated with colitis. This micro-nano drug delivery platform achieves sequential release of drugs in the inflamed colon, with each component of the system functioning independently and jointly. The outer layer of inulin supplies nutrients for probiotics. The inner core comprises selenocystamine and 3-oxolithocholic acid, which polarize macrophages towards an anti-inflammatory phenotype and regulate adaptive immunity by inhibiting T H 17-cell differentiation, respectively. In an acute colitis mouse model, this therapeutic system ameliorates colonic inflammation, enhances the abundance of gut microbiota, and modulates the mucosal immune system, showing potential in preventing colitis.}, archive = {J_ANGEW}, author = {Dongdong Zhu and Xiaocao Ma and Jingguo Wang and Tiantian Chen and Jiahui Yang and Yan Liu and Zhun Lin and Minhao Wu and Tony Y. Hu and Yuanqing Zhang}, doi = {10.1002/anie.202424409}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424409}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A sequential release micro-nano system for colitis therapy via gut microbiota and immune regulation}, volume = {64}, year = {2025}, }
• (2025). Promoting li+-solvents desolvation by engineering nickel single atoms into graphene membrane toward fast sulfur redox kinetics. ANGEW, 64(18), e202424390. (www)

  @article{ , abstract = {Lithium-sulfur (Li−S) batteries featuring high energy density are expected to be next-generation energy storage devices, but are severely impeded by the suppressive Li + -solvents desolvation process at the electrode/electrolyte interface. Herein, a novel electrochemical in situ doping coupled with a self-assembly strategy is proposed to fabricate the graphene membrane anchored by Ni single atoms (Ni-SA-G), aimed at promoting the dissociation kinetics of Li + -solvents complex by combining electrocatalysis and nanochannel sieving effect. Theoretical simulation and in situ Raman spectroscopy characterizations revealed that the Ni-O 5 configuration within the Ni-SA-G membrane is capable of lowering the Li + -solvent dissociation energy barrier and promoting free Li + migration, thereby delivering the fast sulfur redox kinetics. In addition, taking advantage of the Ni-SA-G membrane with a special transport channel, the large-sized solvent molecules and polysulfides were sieved and confined to a great degree. As a result, the Li−S batteries with the Ni-SA-G on separator as cathode front-faces exhibit a high capacity of 1169 mAh g −1 with a good rate performance and outstanding long-term cycling stability, where a capacity decay of only 0.024 % per cycle after 700 cycles can be achieved. Furthermore, the cell with a sulfur loading of 4.78 mg cm −2 delivers a high areal capacity of 4.0 mAh cm −2 at 0.2 C.}, archive = {J_ANGEW}, author = {Songjie He and Juan Yang and Zhibin Liu and Siyu Liu and Jiayi Yu and Jieshan Qiu}, doi = {10.1002/anie.202424390}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting li+-solvents desolvation by engineering nickel single atoms into graphene membrane toward fast sulfur redox kinetics}, volume = {64}, year = {2025}, }
• (2025). Robust peptide-functionalized gold nanoparticles via ethynyl bonding for high-fidelity bioanalytical applications. ANGEW, 64(18), e202424351. (www)

  @article{ , abstract = {While Au−S bonds have been widely applied in preparing gold nanoparticle (AuNP) bioconjugates for biosensing, cell imaging, and biomedical research, biothiols in complex biological environments can seriously interfere with the stability of the conjugates due to ligand exchange. Herein, we communicate a robust and fast strategy for constructing peptide-functionalized AuNP conjugates (PFCs) using the Au−C≡C bond, which can be completed within two minutes. The resulting Au−C≡C PFCs exhibited better stability and resistance to biothiols than the corresponding Au−S PFCs, and also demonstrated excellent stability in high salt concentration, a wide range of pH values, and varying temperatures. The mechanism of Au−C≡C conjugation was confirmed using molecular dynamics simulation and X-ray photoelectron spectroscopy (XPS). The Au−C≡C PFCs significantly improved the signal fidelity in an intracellular caspase imaging assay. Overall, the developed strategy provides a promising approach for constructing AuNP nanoprobes, allowing reliable detection and broadening the potential for diverse biological applications.}, archive = {J_ANGEW}, author = {Jinlian Du and Haili Xu and Xinyue Zhu and Keyu Long and Jiaqi Lang and Ling Jiang and Erhu Xiong and Juewen Liu and Ronghua Yang}, doi = {10.1002/anie.202424351}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424351}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust peptide-functionalized gold nanoparticles via ethynyl bonding for high-fidelity bioanalytical applications}, volume = {64}, year = {2025}, }
• (2025). Hole-mediated lattice oxygen redox design for perovskite oxide catalysts. ANGEW, 64(18), e202424347. (www)

  @article{ , abstract = {Present design and application of perovskite oxide catalysts assume lattice oxygen redox (LOR) mechanisms that depend on lattice oxygen activity without consideration of the entire redox cycle. Herein, using in situ characterizations and theoretical calculations, we uncover a hole-mediated LOR cycle on p-type Sr-deficient SrFeO 3–δ (SFO-Srv) perovskites in CO oxidation reaction. Sr vacancies activate surface lattice oxygen of SFO-Srv and promote formation of highly covalent Fe (4–x)+ -O (2–x)– sites. In situ electrical conductivity measurement demonstrates that holes directly participate in the entire LOR cycle, and are reversibly consumed and regenerated in reducing/oxidizing atmosphere via Fe (4–x)+ -O (2–x)– sites of SFO-Srv. Hole-mediated LOR in SFO-Srv, as revealed by in situ soft X-ray absorption spectroscopy, occurs through changing in covalency of Fe−O bonds, O 2p hole state, and electron density of Fe sites. 18 O 2 labeling experiment further confirms an improved Mars–van Krevelen pathway in the hole-mediated LOR cycle, which accounts for a ten-times enhancement of SFO-Srv for CO reaction rate over that of SFO alone.}, archive = {J_ANGEW}, author = {Xinbo Li and Xiyang Wang and Yaowen Wang and Jingze Shao and Yimin A. Wu and Subhajit Jana and Haozhe Liu and Yue Peng and Zhiyao Wu and Zhen Li and Yingge Cong and Yawen Zhang and Guangshe Li and Liping Li}, doi = {10.1002/anie.202424347}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424347}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hole-mediated lattice oxygen redox design for perovskite oxide catalysts}, volume = {64}, year = {2025}, }
• (2025). Engineering oxygen intermediates adsorption on amorphous NiFe alloys for highly active and selective electrochemical biomass conversion. ANGEW, 64(18), e202424345. (www)

  @article{ , abstract = {Electrochemical 5-hydroxymethylfurfural (HMF) oxidation reaction (HMFOR) offers a promising route to transform biomass into value-added chemicals. However, the competing oxygen evolution reaction (OER) greatly limits the HMFOR selectivity. Herein, we report a facile doping strategy to engineer oxygen intermediates adsorption on amorphous NiFe alloys to boost highly selective electrochemical HMF oxidation to produce 2,5-furandicarboxylic acid (FDCA), among which, amorphous Mn-doped NiFeB alloy displays a low HMFOR onset potential of 1.35 V vs . RHE, achieving 100 % HMF conversion with 88 % FDCA selectivity at an applied potential of 1.4 V vs . RHE, outperforming amorphous NiFeB (73 % FDCA selectivity) and Mo-doped NiFeB (65 % FDCA selectivity) alloys. Experimental characterizations suggest that the introduction of Mn/Mo into amorphous NiFeB alloy can increase/decrease its electronic density and thus strengthen/weaken oxygen intermediates adsorption. Operando experiments indicate that the amorphous Mn-doped NiFeB alloy can significantly reduce the onset potential to form active Ni 3+ species, which spontaneously react with HMF via nucleophile dehydrogenation to form FDCA. Furthermore, in situ infrared spectroscopy measurements verify that the HMF oxidation pathway follows the 5-hydroxymethyl-2-furancarboxylic acid (HMFCA) route rather than the 2,5-diformyfuran (DFF) route.}, archive = {J_ANGEW}, author = {Lei Shi and Weizheng Cai and Feng Zhang and Siqi Li and Xinyang Liu and Yunyi Liu and Peidong Ren and Bin Li and Song Liu and Bin Liu}, doi = {10.1002/anie.202424345}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424345}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering oxygen intermediates adsorption on amorphous NiFe alloys for highly active and selective electrochemical biomass conversion}, volume = {64}, year = {2025}, }
• (2025). Bio-inspired self-assembly of enzyme-micelle systems for semi-artificial photosynthesis. ANGEW, 64(18), e202424222. (www)

  @article{ , abstract = {Supramolecular surfactants provide a versatile platform to construct systems for solar fuel synthesis, for example via the self-assembly of amphiphilic photosensitizers and catalysts into diverse supramolecular structures. However, the utilization of amphiphilic photosensitizers in solar fuel production has predominantly focused on yielding gaseous products, such as molecular hydrogen (H 2 ), carbon monoxide (CO), and methane (CH 4 ) with turnover numbers (TONs) of synthetic catalysts typically in the range of hundreds to thousands. Inspired by biological lipid-protein interactions, we present herein a bio-hybrid assembly strategy that utilizes photosensitizers as surfactants to form micellar scaffolds that interface with enzymes, namely hydrogenases and formate dehydrogenases, for semi-artificial photosynthesis. Specifically, surfactants with a tris(2,2’-bipyridine)ruthenium(II) head group provide high photocatalytic activity upon association with the enzymes as their positively charged [Ru(bpy) 3 ] 2+ complex electrostatically interacts with the enzymes favorably to enable direct electron transfer at the micelle-enzyme interface. Time-resolved absorption and emission spectroscopy support the beneficial charge carrier dynamics of the reductively quenched [Ru(bpy) 3 ] + species when the enzymes are introduced in the micellar solution. Thus, a biohybrid concept is introduced for solar fuel synthesis using a biomimetic enzyme-micellar system, providing also a platform for other photocatalytic transformations using enzymes in the future.}, archive = {J_ANGEW}, author = {Yongpeng Liu and Santiago Rodríguez-Jiménez and Hongwei Song and Andrea Pannwitz and Dongseok Kim and Ana M. Coito and Rita R. Manuel and Sophie Webb and Lin Su and Shannon A. Bonke and Ross D. Milton and Inês A. C. Pereira and Sylvestre Bonnet and Leif Hammarström and Erwin Reisner}, doi = {10.1002/anie.202424222}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424222}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bio-inspired self-assembly of enzyme-micelle systems for semi-artificial photosynthesis}, volume = {64}, year = {2025}, }
• (2025). Iridium-catalyzed asymmetric allylic alkylation of boron enolates to construct acyclic all-carbon quaternary stereocenters. ANGEW, 64(18), e202424141. (www)

  @article{ , abstract = {Enolates are ubiquitous intermediates in organic synthesis. Among them, boron enolates exhibit distinctive reactivity patterns and selectivities due to the presence of a boron atom, making their synthesis highly attractive. Although methods for accessing ketone- or ester-derived boron enolates are well-developed, much less progress has been made in the development of aldehyde-derived boron enolates due to aldehydes′ high tendency toward self-condensation. Therefore, the practical applications of aldehyde-derived boron enolates are significantly hindered. We present herein an efficient method for the preparation of aldehyde-derived boron enolates via the 1,2-hydroboration of ketenes with boranes, avoiding the use of acidic R 2 BCl/R 2 BOTf and bases and leading to improved functional group tolerance. Utilizing this convenient protocol, we developed an Ir-catalyzed asymmetric allylic alkylation of boron enolates, yielding a wide array of chiral aldehydes bearing acyclic all-carbon quaternary centers with high chemo-, regio-, and enantioselectivity, which are prevalent in various natural products and bioactive molecules. The synthetic utility and practicality of this method are demonstrated through gram-scale reactions and asymmetric syntheses of the ent-5HT1 A antagonist as well as biological activity studies in inhibiting the growth of plant pathogens.}, archive = {J_ANGEW}, author = {Liu Yang and Mengzhi Yang and Zhenchao Wang and Wanxiang Zhao}, doi = {10.1002/anie.202424141}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iridium-catalyzed asymmetric allylic alkylation of boron enolates to construct acyclic all-carbon quaternary stereocenters}, volume = {64}, year = {2025}, }
• (2025). Direct observation of electron donation onto the reactants and a transient poisoning mechanism during CO2 electroreduction on ni single atom catalysts. ANGEW, 64(18), e202424087. (www)

  @article{ , abstract = {Single atom catalysts (SACs) are an important class of materials that mediate chemical reduction reactions, a key subset of which is Ni within a carbon support for the electrochemical CO 2 reduction reaction (CO 2 RR). However, how the metal atom/clusters and the carbon-based support act in concert to catalyze CO 2 RR is not well understood, with most reports attributing activity solely to the Ni-N x /C moieties. To address this gap, we have undertaken a mechanistic investigation, employing in situ X-ray absorption spectroscopy (XAS) coupled with electrochemical studies and density functional theory (DFT) calculations to further understand how Ni single atoms work in conjunction with the nitrogen-doped carbon matrix to promote CO 2 RR to CO, and how the presence of impurities such as those present in CO 2 -containing waste flue gases (including NO x , and CN − ) changes the catalyst upon reduction. In contrast to previous works, we do not find strong evidence for a purely metal-based reduction upon application of negative reductive potentials. Instead, we present evidence for an increase in the equatorial vs. axial splitting of Ni, consistent with electrons moving onto the reactants via the Ni single atom 3d z 2 orbital. In addition, we demonstrate a transient poisoning mechanism of the Ni SAC by nitrite and thiocyanate, explaining the recovery of activity during CO 2 RR. These insights can aid the design of practical CO 2 valorization technologies.}, archive = {J_ANGEW}, author = {Josh Leverett and Ghazal Baghestani and Thanh Tran-Phu and Jodie A. Yuwono and Priyank Kumar and Bernt Johannessen and Darcy Simondson and Haotien Wen and Shery L. Y. Chang and Antonio Tricoli and Alexandr N. Simonov and Liming Dai and Rose Amal and Rahman Daiyan and Rosalie K. Hocking}, doi = {10.1002/anie.202424087}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202424087}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct observation of electron donation onto the reactants and a transient poisoning mechanism during CO2 electroreduction on ni single atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Achieving highly reversible Mn2+/MnO2 conversion reaction in electrolytic zn-MnO2 batteries via electrochemical-chemical process regulation. ANGEW, 64(18), e202423999. (www)

  @article{ , abstract = {Despite the widespread interest in electrolytic Zn-MnO 2 batteries with excellent output voltage and high theoretical capacity, the spontaneous disproportionation reaction of free Mn 3+ along with the disorderly deposited inactive MnO 2 results in the low Mn 2+ /MnO 2 conversion reversibility, which seriously affects their cycling stability. Here, we propose a novel aqueous SiO 2 colloidal electrolyte with FeSO 4 mediator (denoted as SF electrolyte) based on a bidirectional electrochemical-chemical model to achieve dual regulation of the MnO 2 deposition/dissolution process. During the charging process, the SiO 2 colloidal particles located at the carbon felt interface and the electrolyte bulk phase simultaneously provide sufficient disproportionation sites for the diffused Mn 3+ to guide the orderly rapid deposition of MnO 2 . Meanwhile, the introduction of Fe 2+ mediators during the discharge process can sufficiently react with MnO 2 on the SiO 2 particles in the electrolyte, thereby further enabling the efficient conversion of Mn 2+ /MnO 2 . Consequently, electrolytic Zn-MnO 2 battery with SF electrolyte can stably run for 550 cycles at 10 mAh cm −2 and achieve superior reversibility at a high area capacity of 20 mAh cm −2 . This work demonstrates the feasibility of colloidal electrolytes in modulating electrochemical-chemical processes to stabilize electrolytic Zn-MnO 2 batteries.}, archive = {J_ANGEW}, author = {Hengyue Chen and Pengchao Ruan and Hao Zhang and Zeinhom M. El-Bahy and Mohamed M. Ibrahim and Bingan Lu and Jiang Zhou}, doi = {10.1002/anie.202423999}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202423999}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving highly reversible Mn2+/MnO2 conversion reaction in electrolytic zn-MnO2 batteries via electrochemical-chemical process regulation}, volume = {64}, year = {2025}, }
• (2025). Elucidating the role of electric fields in fe oxidation via an environmental atom probe. ANGEW, 64(18), e202423434. (www)

  @article{ , abstract = {We quantify the effects of intensely applied electric fields on the Fe oxidation mechanism. The specimen are pristine Fe single crystals exposing a variety of surface structures identified by field ion microscopy. These crystals are simultaneously exposed to low pressures of pure oxygen gas, on the order of 10 −7 mbar, while applying intense electric fields on their surface of several tens of volts per nanometer. The local composition of the different surface structures is probed directly and in real time using an Environmental Atom Probe and successfully compared with first principles-based models. We found that rough Fe{244} and Fe{112} facets are more reactive toward oxygen than compact Fe{024} and Fe{011} facets. Results demonstrate that the influence of an electric field on the oxidation kinetics depends on the timescales that are involved as the system evolves toward equilibrium. The initial oxidation kinetics show that strong increases in electric fields facilitate the formation of an oxide. However, as one approaches equilibrium, high field values mitigate this formation. Ultimately, this study elucidates how high externally applied electric fields can be used to dynamically exploit reaction dynamics at the nanoscale towards desired products in a catalytic reaction at mild reaction conditions.}, archive = {J_ANGEW}, author = {Sten V. Lambeets and Naseeha Cardwell and Isaac Onyango and Mark G. Wirth and Eric Vo and Yong Wang and Pierre Gaspard and Cornelius F. Ivory and Daniel E Perea and Thierry Visart de Bocarmé and Jean-Sabin McEwen}, doi = {10.1002/anie.202423434}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202423434}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elucidating the role of electric fields in fe oxidation via an environmental atom probe}, volume = {64}, year = {2025}, }
• (2025). Synthesis of α-N-heteroaryl ketones by nickel-catalyzed chemo-, regio- and enantioselective carbonylation of alkenes and N-alkenyl heteroarenes. ANGEW, 64(18), e202423426. (www)

  @article{ , abstract = {Enantioenriched α-aminoketones serve as important substructures in life science and precursors for the synthesis of diverse value-added targets in organic and biochemistry. However, direct access to enantioenriched α-aminoketones from simple and readily available starting materials remains a formidable challenge. Herein, we report an unprecedented nickel-catalyzed asymmetric cross-coupling protocol for the synthesis of enantioenriched α- N -heteroaryl ketones from alkenes and enamines in the presence of a carbon monoxide surrogate. The success of this reaction relies on the sorting of two different alkenes along with the control of regio- and enantioselectivity. This reductive-oxidative carbonylation of enamines and unactivated alkenes featuring the use of a carbon monoxide surrogate allows for the gas-free streamlined assembly of enantioenriched α- N -heteroaryl ketones from two distinct alkenes.}, archive = {J_ANGEW}, author = {Xiao-Yi Chen and Qiong Yu and Wei Shu}, doi = {10.1002/anie.202423426}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202423426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of α-N-heteroaryl ketones by nickel-catalyzed chemo-, regio- and enantioselective carbonylation of alkenes and N-alkenyl heteroarenes}, volume = {64}, year = {2025}, }
• (2025). Straightforward formation of borirenes from boroles and dialkynes. ANGEW, 64(18), e202423391. (www)

  @article{ , abstract = {We report a selective one-step synthesis of perarylated borirenes by reaction of antiaromatic boroles with 1,4-diarylbuta-1,3-diynes. Mechanistic studies, both experimental and computational, reveal key intermediates, including boranorbornadiene and 7-borabicyclo[4.1.0]heptadiene species, which are all in equilibrium with each other, ultimately leading to borirene formation by migration of the boranediyl bridge from the cyclohexadiene ring to the remaining exocyclic alkyne residue.}, archive = {J_ANGEW}, author = {Pedro H. R. Oliveira and Marieli O. Rodrigues and Caren D. G. Da Silva and Josina L. Bohlen and Merle Arrowsmith and Arumugam Jayaraman and Lukas Lubczyk and Felipe Fantuzzi and Eufrânio N. da Silva Júnior and Holger Braunschweig}, doi = {10.1002/anie.202423391}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202423391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Straightforward formation of borirenes from boroles and dialkynes}, volume = {64}, year = {2025}, }
• (2025). Manganese-ketenimine intermediates as active catalysts in the michael addition of unactivated nitriles to α,β-unsaturated ketones. ANGEW, 64(18), e202423275. (www)

  @article{ , abstract = {The Michael addition of unactivated nitriles to α,β-unsaturated ketones is a challenging yet desirable strategy for installing alkyl cyano-groups (R-CN) in organic molecules. However, despite formidable efforts, using acetonitrile as a Michael donor in these reactions has remained a significant challenge. Herein, we report a highly active manganese(I) complex [(PC NHC P)Mn(CO) 2 H] ( 1 ), which chemoselectively catalyzes the 1,4-addition of unactivated nitriles (incl. acetonitrile) to α,β-unsaturated ketones. The developed methodology operates under mild conditions, does not require any additives or bases, features low catalyst loadings (1 mol %), fast reaction times (2–8 hours), and is compatible with a wide variety of functional groups, including halides, trifluoromethyl, alkenyl, alkynyl, and (hetero)aryl groups. Extensive mechanistic studies revealed that after base-free activation of the nitrile, either the N-bound manganese-ketenimine (propionitrile or benzyl cyanide) or the C-bound manganese-cyanoalkyl (acetonitrile) complex is formed. The difference in stability of these two species explains why more sterically hindered and presumably less activated nitriles ( i.e ., propionitrile, and butyronitrile) show higher reactivity than their corresponding more activated congeners ( i.e ., acetonitrile). Finally, the practicality of our approach was demonstrated through a gram-scale reaction and subsequent derivatizations of the obtained product into important organic motifs such as ene-lactams and tetrahydropyridines.}, archive = {J_ANGEW}, author = {Kartick Dey and Akhanda Gorai and Katarzyna Młodzikowska-Pieńko and Natalia Fridman and Idan Avigdori and Renana Gershoni-Poranne and Graham de Ruiter}, doi = {10.1002/anie.202423275}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202423275}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manganese-ketenimine intermediates as active catalysts in the michael addition of unactivated nitriles to α,β-unsaturated ketones}, volume = {64}, year = {2025}, }
• (2025). Tuning zn2+ deposition kinetics towards deep-reversible zinc metal batteries with all-climate adaptability. ANGEW, 64(18), e202423252. (www)

  @article{ , abstract = {Uncontrollable Zn dendrites and severe hydrogen evolution reaction (HER) hamper the practical application of aqueous zinc-metal batteries, which closely related to the deposition kinetics and thermodynamic stability of Zn anode. In this work, we returned to the classic perspectives of kinetics and thermodynamics, introducing a small amount of reduced glutathione (RGSH) to reshape the kinetic behavior of Zn 2+ deposition and increasing the thermodynamic energy barrier of HER. Specifically, the steric hindrance effect of RGSH tuned the electrochemical reduction kinetics to match Zn 2+ migration and increased the proportion of Zn 2+ in the bulk phase migration, thereby inducing dendrite-free deposition behavior with ordered (002) texturing. Meanwhile, RGSH with abundant hydrogen bond donors and acceptors reconfigures the coordination network of water molecules for all-climate adaptability, eliminating the accumulation of “dead Zn” at low temperature and the HER corrosion at high temperature. As a result, the advanced Zn||Zn symmetric cells deliver an extra-long cycling performance (over 4600 h) and a wide temperature tolerance (−20 °C~70 °C). Additionally, the NH 4 V 4 O 10 ||Zn full cell can operate stably for over 1000 cycles with 84.3 % capacity retention. Surprisingly, the practical NH 4 V 4 O 10 ||Zn pouch cell with limited N/P ratio (2.3) reserved 84.1 % capacity after 150 cycles.}, archive = {J_ANGEW}, author = {Yining Chen and Shuang Zhou and Jianwen Li and Xin Zhang and Chuancong Zhou and Xiaodong Shi and Chunxiao Zhang and Guozhao Fang and Shuquan Liang and Zhi Su and Anqiang Pan}, doi = {10.1002/anie.202423252}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202423252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning zn2+ deposition kinetics towards deep-reversible zinc metal batteries with all-climate adaptability}, volume = {64}, year = {2025}, }
• (2025). Towards ultra-stable wide-temperature zinc-ion batteries by using ion-sieving organic framework membrane. ANGEW, 64(18), e202423118. (www)

  @article{ , abstract = {Aqueous zinc-ion batteries (AZIBs) offer notable advantages in safety and cost-efficiency, but Zn dendrite growth and unstable interfacial reactions hinder their commercial viability. A crucial factor in addressing these challenges lies in optimizing the separator to regulate ion transport and stabilize electrode interfaces. Herein, we propose a covalent organic framework (COF)-based separator with quasi-single-ion conduction, specifically a Zn 2+ -substituted sulfonate COF (COF-Zn) membrane, designed to tackle these issues. Featuring a high Zn transference number (0.87) and a thin 25 μm profile, the COF-Zn separator allows for reduced electrolyte usage (20 μL mg −1 ) while effectively minimizing cathode dissolution. Its quasi-single-ion conductivity and electronegative properties improve Zn anode's stability by lowering water activity. This separator enables ultra-stable AZIBs, as demonstrated in various full cells including Zn//4,5,9,10-pyrenetetrone (PTO), Zn//I 2 and Zn//V 2 O 5 . Remarkably, the Zn//PTO cell achieves an energy density of 260 Wh kg −1 , 100 % capacity retention under reduced electrolyte conditions, and stable all-weather cycling from −40 to +100 °C with a customized electrolyte.}, archive = {J_ANGEW}, author = {Jie Xu and Yuting Yang and Qingyu Dai and Zhangyu Zheng and Yongjie Cao and Yuwen Cheng and Bo Peng and Lianbo Ma and Yonggang Wang}, doi = {10.1002/anie.202423118}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202423118}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards ultra-stable wide-temperature zinc-ion batteries by using ion-sieving organic framework membrane}, volume = {64}, year = {2025}, }
• (2025). Copper(I) halide complex featuring blue thermally activated delayed fluorescence and aggregate induced emission for efficient X-ray scintillation and imaging. ANGEW, 64(18), e202422995. (www)

  @article{ , abstract = {Developing solution-processable and stable scintillators with high light yields, low detection limits and high imaging resolutions holds great significance for flexible X-ray imaging. However, attaining an optimal equilibrium among X-ray absorption capacity, exciton utilization efficiency, and decay lifetime of scintillators remains a substantial challenge. Here, a new Cu(I) halide complex was synthesized in a mild condition. It exhibits intense blue thermally activated delayed fluorescence (TADF), remarkable aggregation-induced emission (AIE) characteristic, as well as good water-oxygen stability and photochemical stability. Notably, the complex shows excellent radiation resistance and efficient radioluminescence (RL) with an ultra-low detection limit of 42.5 nGy air s −1 . This superior scintillation performance can be attributed to the synergistic effect of effective X-ray absorption by the heavy Cu 2 I 2 core, the high radiation-induced exciton utilization rate in TADF process, and the remarkable suppression of non-radiative transitions by the restriction of intramolecular motions in solid state. Furthermore, the favourable solution processability of the complex facilitates the successful fabrication of a flexible film, achieving high-quality X-ray imaging with a resolution of 17.3 lp mm −1 . This work highlights the potential of hybrid Cu(I) halides with AIE-TADF effects for high-energy radiation detection and imaging, opening up new avenues for the exploration of cost-effective and high-performance scintillators.}, archive = {J_ANGEW}, author = {Jiaxin Jiang and Yunfang Zhao and Zhijia Li and Yangxingyu Ye and Zhiyuan Wu and Feilong Jiang and Lian Chen and Maochun Hong}, doi = {10.1002/anie.202422995}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202422995}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper(I) halide complex featuring blue thermally activated delayed fluorescence and aggregate induced emission for efficient X-ray scintillation and imaging}, volume = {64}, year = {2025}, }
• (2025). Crystal-facet-controlled internal electric field in MOF/COF heterojunction towards efficient photocatalytic overall water splitting. ANGEW, 64(18), e202422940. (www)

  @article{ , abstract = {Covalently integrating two type of crystalline porous materials, metal–organic frameworks (MOFs) and covalent organic frameworks (COFs), to form heterostructure photocatalysts inheriting their structural merits has shown inherent advantages in hydrogen evolution reaction. However, how to control the internal electric field in aimed MOF/COF heterojunction to achieve an improved photocatalytic activity is still ambiguous. Herein, for the first time, we report a rational control of the internal electric field in MOF/COF heterojunction by engineering the crystal facet of MOFs to achieve enhanced photocatalytic overall water splitting (OWS) activity. A new type of covalently connected MOF/COF photocatalytic system based on NH 2 -MIL-125(Ti) and TpBpy-COF was synthesized. As confirmed, the exposed crystal facet of MOFs greatly affected the resultant activity of MOF/COF system. The combination of decahedron NH 2 -MIL-125(Ti) and TpBpy-COF shows an optimal OWS activity with the H 2 and O 2 evolution rates of 331.6 and 165.7 μmol g −1 h −1 under visible light, respectively, which is the best performance in COFs or COF-based photocatalyst at present. The great influence of formed anisotropic facets on internal electric field of the S-scheme MOF/COF heterojunction interface is fully confirmed by various characterizations, and the active crystal facet of NH 2 -MIL-125(Ti) for water oxidation reaction is further proved.}, archive = {J_ANGEW}, author = {Xiaoyu Chu and Shikai Liu and Bing-Bing Luan and Ying Zhang and Yuming Xi and Lu-Hua Shao and Feng-Ming Zhang and Ya-Qian Lan}, doi = {10.1002/anie.202422940}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202422940}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystal-facet-controlled internal electric field in MOF/COF heterojunction towards efficient photocatalytic overall water splitting}, volume = {64}, year = {2025}, }
• (2025). Pallada-electrocatalysis enables distal regioselective and atroposelective olefination reactions. ANGEW, 64(18), e202422876. (www)

  @article{ , abstract = {Regioselective and enantioselective C-H functionalization is a valuable method for synthesizing chiral and complex molecules. However, it often requires large amounts of toxic oxidants and high temperature, making it environmentally and economically adverse. Additionally, these traditional approaches generally suffer from regioselectivity and enantioselectivity issues. To overcome these limitations, a new mechanism is needed to control both of these simultaneously. Herein, we report the first Pd catalyzed regioselective distal and atroposelective olefination of simple arenes/biaryls via an electrooxidative reaction pathway. This unique electro-oxidative strategy with Pd(II) catalysis demonstrates unprecedented access to ‘regio-resolved’ reactions, furnishing chiral molecule synthesis under dynamic kinetic resolution without the conventional requirement of metal-based oxidants and thermal energy. Both electroanalytical studies and DFT calculations suggest the involvement of a Pd(II)/Pd(IV) catalytic cycle via a crucial Pd(III) intermediate that initiates both the distal and atroposelective olefination reactions.}, archive = {J_ANGEW}, author = {Subir Panja and Avishek Pan and Swastik Biswas and Chandan Das and Aritra Guha and Roshan Y. Nimje and T. G. Murali Dhar and Anuradha Gupta and Arvind Mathur and Arnab Dutta and Lisa Roy and Debabrata Maiti}, doi = {10.1002/anie.202422876}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202422876}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pallada-electrocatalysis enables distal regioselective and atroposelective olefination reactions}, volume = {64}, year = {2025}, }
• (2025). Cascade lanthanide-triplet energy transfer for nanocrystal-sensitized organic photon upconversion. ANGEW, 64(18), e202422575. (www)

  @article{ , abstract = {Sensitized organic photon upconversion via triplet-triplet annihilation (TTA) shows significant potential for energy conversion and photocatalysis, but achieving efficient upconversion across multiple wavelengths with single-wavelength near-infrared (NIR) excitation remains a daunting challenge. Here, we report a strategy utilizing lanthanide-doped nanocrystals (LnNCs) to sensitize TTA upconversion in multiple organic emitters under NIR excitation, achieving an anti-Stokes shift of up to 1.1 eV. This approach leverages a cascade lanthanide-triplet energy transfer design, adopting an interfacial energy transfer pathway via lanthanide ions to surface energy relay molecules for extended triplet sensitization. It allows consecutive transfer of photon energy from LnNCs to TTA emitters, mitigating energy mismatch between the triplet levels of emitters and excitation photon energies. The use of LnNCs enhances energy transfer efficiency through the unique spin-orbital coupling and narrow-band absorption properties of lanthanide ions. Our approach offers tunable upconversion emission, minimized energy loss during sensitization, and improved chemical stability of LnNCs. Additionally, we demonstrate the utility of this system in NIR-induced photopolymerization, showcasing its potential for applications such as 3D printing and photocatalysis.}, archive = {J_ANGEW}, author = {Zhijie Ju and Renren Deng}, doi = {10.1002/anie.202422575}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202422575}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cascade lanthanide-triplet energy transfer for nanocrystal-sensitized organic photon upconversion}, volume = {64}, year = {2025}, }
• (2025). The substituent-effect in NHCP-plumbylenes with a phosphaplumbene character. ANGEW, 64(18), e202422186. (www)

  @article{ , abstract = {This work explores the use of plumbylene-phosphinidenes to address the challenge of isolating P=Pb bonds. Herein, we report the synthesis of three N -heterocyclic carbene phosphinidene (NHCP) substituted chlorotetrylene dimers [(IDipp)PECl] 2 (E=Ge, Sn, Pb; IDipp=C([N-(2,6- i Pr 2 -C 6 H 3 )CH] 2 )). Substituent attachment via salt metathesis (E=Sn, Pb) enables the isolation of NHCP-silyl-substituted stannylene (IDipp)PSn(SiTms 2 SiTol 3 ) as well as NHCP-silyl- and NHCP-aryl-substituted plumbylenes (IDipp)PPb(SiTms 2 SiTol 3 ) and (IDipp)PPb( m Ter) ( m Ter=2,6-Mes 2 C 6 H 3 , Tms=Trimethylsilyl). Access to these structures not only expands this chemistry to the heaviest of group 14 elements but also provides a deeper understanding of the substituent effect on NHCP-tetrylene bonding. Computational studies demonstrate that both silyl- and aryl-substituted species exhibit partial multiple bond character, with the silyl-substituted species showing higher bond orders and reduced polarization. This is further supported by the short P−E bond lengths observed in their solid-state structures. Finally, the formal [2+2] cycloaddition of diphenylketene to (IDipp)PPb( m Ter) provides experimental evidence for the ability of NHCP-plumbylenes to serve as synthetic equivalents of P=Pb double bonds.}, archive = {J_ANGEW}, author = {Martin E. Doleschal and Arturo Espinosa Ferao and Arseni Kostenko and Fiona J. Kiefer and Shigeyoshi Inoue}, doi = {10.1002/anie.202422186}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202422186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The substituent-effect in NHCP-plumbylenes with a phosphaplumbene character}, volume = {64}, year = {2025}, }
• (2025). Mixing functionality in polymer electrolytes: A new horizon for achieving high-performance all-solid-state lithium metal batteries. ANGEW, 64(18), e202422169. (www)

  @article{ , abstract = {Solid polymer electrolytes (SPEs) are a key materials component for all-solid-state lithium metal batteries (ASSLMBs). In these membrane-like films, accelerating Li + migration while enhancing the mechanical strength of SPEs is challenging. Herein, we introduce a new concept of supramolecularly organized, cross-linked polymer electrolyte (PCPE) by mixing an ion-conducting, multi-arm boron-containing oligomer (MBO) solid plasticizer into a polyethylene oxide (PEO)-lithium salt matrix. Studies reveal that the Lewis acid-base interaction between the Lewis-acidic boron sites of MBO and lithium-salt anions induces an amorphous MBO-salt assembly subphase with percolating nanochannels for rapid Li + transport. Meanwhile, due to the structural compatibility of the multiple linear arms of MBO with PEO, a supramolecular polymer network is obtained which partly crystallizes around the ionic nanodomains, offering an PCPE with improved mechanical strength hosting interconnected ion transport pathways. The resulting PCPE shows simultaneously enhanced ionic conductivity, improved mechanical properties, and film interface stability, which enable a dendrite-free Li/Li symmetric cell which could be cycled over 2600 h. Excellent electrochemical performance is also demonstrated in a close-to-practical high capacity ASSLMBs.}, archive = {J_ANGEW}, author = {Yufeng Ren and Suli Chen and Mateusz Odziomek and Junhong Guo and Pengwu Xu and Haijiao Xie and Zhihong Tian and Markus Antonietti and Tianxi Liu}, doi = {10.1002/anie.202422169}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202422169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mixing functionality in polymer electrolytes: A new horizon for achieving high-performance all-solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Solvent chemistry manipulated iodine redox thermodynamics for durable iodine batteries. ANGEW, 64(18), e202422163. (www)

  @article{ , abstract = {The diverse valences of iodine enable it with multi-electron transfer capability for energy dense batteries. However, previous studies indicate that the primary I − /I 2 redox couple exhibits distinct behaviors depending on electrolyte choice, with the mechanistic basis of aqueous versus nonaqueous systems remaining unclear. Here, we elucidated the solvent effect on iodine redox, particularly focusing on polyiodide formation and their molecular interaction correlations. We validate that a thermodynamically one-step conversion reaction (I 2 ↔ I − ) occurs in the protic solvents, while it is a two-step transformation (I 2 ↔ I 3 − ↔ I − ) in aprotic solvents. This distinction arises from strong electron-donating properties in aprotic solvents that facilitate charge transfer with iodine, promoting complexation with iodide as solvent⋅I 3 − species. Conversely, protic solvents form additional hydrogen bonds with iodine, alleviating polarization and reducing interaction with iodide. Furthermore, to address the limitations of single protic electrolytes – characterized by sluggish dissolution-precipitation and slow ion migration rates – we propose a hybrid electrolyte combining water and ethylene glycol. These hybrids enhance iodine redox kinetics, inhibits I 3 − generation, and modifies the Zn 2+ solvation structure to mitigate zinc anode corrosion and dendrite. The Zn−I 2 batteries demonstrates exceptional long-term cycling stability in a wide temperature range, highlighting its potential for practical applications.}, archive = {J_ANGEW}, author = {Tingting Liu and Chengjun Lei and Wei Yang and Huijian Wang and Wenjiao Ma and Jinye Li and Xiao Liang}, doi = {10.1002/anie.202422163}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202422163}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent chemistry manipulated iodine redox thermodynamics for durable iodine batteries}, volume = {64}, year = {2025}, }
• (2025). Atropisomerism in triarylboranes: Lewis base assisted rotation at C−B stereogenic axis in asymmetrical boron lewis acids. ANGEW, 64(18), e202421931. (www)

  @article{ , abstract = {The synthesis, properties and structural requirements for atropisomerism at the C−B bond in boron Lewis acids such as triarylboranes have been understudied so far. We report the first series of atropisomeric triarylboranes constituted of a naphthyl rotor and a dihydro-9-bora-anthracenyl stator subunits, connected by a C−B stereogenic axis. Through systematic crystallographic, kinetic, photophysical and quantum chemical studies, the mechanisms, rates and barriers of diastereomerization and enantiomerization were determined. The orthogonal arrangement between the naphthyl and the dihydro-9-bora-anthracenyl scaffold moiety hamper the rotation of these two moieties around their Csp 2 −B bonds, enabling chiral resolution leading to enantiopure triarylboranes of high configurational stability. Furthermore, we fully elucidated a Lewis-base assisted pathway controlling the rotation speed at the C−B stereogenic axis, enabling the atropisomerical behavior of these triarylboranes be controlled by a Lewis base.}, archive = {J_ANGEW}, author = {Thu-Hong Doan and Aurélien Chardon and Nicolas Vanthuyne and Tárcius N. Ramos and Nikolay Tumanov and Luca Fusaro and Muriel Albalat and Laurent Collard and Johan Wouters and Benoît Champagne and Guillaume Berionni}, doi = {10.1002/anie.202421931}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202421931}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atropisomerism in triarylboranes: Lewis base assisted rotation at C−B stereogenic axis in asymmetrical boron lewis acids}, volume = {64}, year = {2025}, }
• (2025). Gate-tunable circular photogalvanic effects in two-dimensional perovskite ferroelectric-based transistor toward multi-state memory. ANGEW, 64(18), e202421463. (www)

  @article{ , abstract = {Spintronics has long been an exciting branch of condensed matter science, among which the spin splitting of energy bands in an inversion asymmetric material endows the circular photogalvanic effects (CPGE) toward high-performance spin-based optoelectronic devices. Here, we have successfully achieved gate-tunable CPGE in a biaxial perovskite ferroelectric ( n -HA) 2 CsPb 2 Br 7 ( 1 , n -HA is n -heptanamine), involving the broken symmetry from its spontaneous polarization. Strikingly, under left- and right-circularly polarized light, this CPGE acquires a large anisotropy factor for photocurrents up to ~1.04, far beyond most organic semiconductors and chiral counterparts (<0.2). It is the large splitting coefficient along the k y direction (~1.476 eV Å) that contributes to the significant realization of CPGE in 1 . Notably, this spin-based CPGE of 1 has been modulated via the gate-voltage manipulation in its transistor-type devices, leading to multi-state memory behaviors. That is, six distinct conductance states are obtained under circularly polarized light, containing the original, high/low-state responses L (-1,0,1) to the left circularly polarized light, as well as three right components R (-1,0,1). This study establishes a pathway for further exploration toward multi-state memory in the field of ferroelectric integrated devices.}, archive = {J_ANGEW}, author = {Wuqian Guo and Haojie Xu and Fapeng Sun and Yi Liu and Yu Ma and Wei Liu and Yue Zhao and Zhihua Sun and Junhua Luo}, doi = {10.1002/anie.202421463}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202421463}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gate-tunable circular photogalvanic effects in two-dimensional perovskite ferroelectric-based transistor toward multi-state memory}, volume = {64}, year = {2025}, }
• (2025). Chemical proteomics reveals human off-targets of fluoroquinolone induced mitochondrial toxicity. ANGEW, 64(18), e202421424. (www)

  @article{ , abstract = {Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. In this study, focusing on the most commonly prescribed FQs Ciprofloxacin and Levofloxacin, whole proteome analyses revealed prominent mitochondrial dysfunction in human cells, specifically of the complexes I and IV of the electron transport chain (ETC). Furthermore, global untargeted chemo-proteomic methodologies such as photo-affinity profiling with FQ-derived probes, as well as derivatization-free thermal proteome profiling, were applied to elucidate human protein off-targets of FQs in living cells. Accordingly, the interactions of FQs with mitochondrial AIFM1 and IDH2 have been identified and biochemically validated for their contribution to mitochondrial dysfunction. Of note, the FQ induced ETC dysfunction via AIFM1 activates the reverse carboxylation pathway of IDH2 for rescue, however, its simultaneous inhibition further enhances mitochondrial toxicity. This off-target discovery study provides unique insights into FQ toxicity enabling the utilization of identified molecular principles for the design of a safer FQ generation.}, archive = {J_ANGEW}, author = {Till Reinhardt and Yassmine El Harraoui and Alex Rothemann and Adrian T. Jauch and Sigrid Müller-Deubert and Martin F. Köllen and Timo Risch and Lianne JHC Jacobs and Rolf Müller and Franziska R. Traube and Denitsa Docheva and Stefan Zahler and Jan Riemer and Nina C. Bach and Stephan A. Sieber}, doi = {10.1002/anie.202421424}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202421424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical proteomics reveals human off-targets of fluoroquinolone induced mitochondrial toxicity}, volume = {64}, year = {2025}, }
• (2025). Tailoring molecular diffusion in core-shell zeolite imidazolate framework composites realizes efficient kinetic separation of xylene isomers. ANGEW, 64(18), e202420953. (www)

  @article{ , abstract = {The separation of xylene isomers is a critical and energy-intensive process in the petrochemical industry, primarily due to their closely similar molecular structures and boiling points. In this work, we report the synthesis and application of a novel core–shell zeolitic imidazolate framework (ZIF) composite, ZIF-65@ZIF-67, designed to significantly enhance the kinetic separation of xylene isomers through a synergistic “shell-gated diffusion and core-facilitated transport” strategy. The external ZIF-67 shell selectively restricts the diffusion of larger isomers (MX and OX), while the internal ZIF-65 core accelerates the diffusion of PX, thereby amplifying the diffusion differences among the isomers. This architecture yields remarkable improvements in both selectivity and diffusion rates, as demonstrated by vapor-phase adsorption studies and molecular dynamics simulations. The ZIF-65@ZIF-67 composite exhibits up to 12.5 times higher PX/OX selectivity in liquid-phase adsorption and 3.4 times higher dynamic selectivity in fixed-column breakthrough experiments compared to the individual ZIF components. Theoretical simulations further corroborate the heterogeneous diffusion control mechanism, revealing the time-dependent diffusion regulation within the core–shell architecture. This work underscores the great potential of core–shell MOF composites in optimizing molecular sieving processes for industrially significant separations and highlights a new route for enhancing kinetic separation efficiency in complex multicomponent systems.}, archive = {J_ANGEW}, author = {Linghe Yang and Guangtong Hai and Ying Liu and Fang Zheng and Fuxing Shen and Lihang Chen and Baojian Liu and Zhiguo Zhang and Qiwei Yang and Qilong Ren and Yong Luo and Zongbi Bao}, doi = {10.1002/anie.202420953}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202420953}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring molecular diffusion in core-shell zeolite imidazolate framework composites realizes efficient kinetic separation of xylene isomers}, volume = {64}, year = {2025}, }
• (2025). Synthetic high-throughput microarrays of peptidoglycan fragments as a novel sero-diagnostic tool for patient antibody profiling. ANGEW, 64(18), e202420874. (www)

  @article{ , abstract = {Peptidoglycan (PGN) is a complex biopolymer crucial for cell wall integrity and function of all bacterial species. While the strong inflammatory properties of PGN and its derived muropeptides are well-documented in human innate immune responses, adaptive immunity, including antibody responses to PGN, remain inadequately characterized. Microarray technology represents a cost- and time-efficient method for studying such interactions. Our laser-based technology enables the high-throughput synthesis of biomolecules on functionalized glass slides. Here, this on-chip synthesis was developed for PGN fragments, to generate a variety of 216 stem peptides and attach six different glycan moieties that are major structural components of bacterial cell walls. Thereby, 864 PGN fragments from different Gram-negative and Gram-positive species were generated. The arrays were validated with four different monoclonal antibodies against PGN or poly- N -acetyl glucosamine and identified their epitopes. Finally, proof of concept for antibody profiling in patient samples was performed by comparing a panel of well-characterized plasma samples of epidermolysis bullosa (EB) patients suffering from (chronic) wounds with Staphylococcus aureus infection. EB patients show an increased response to the muramyl dipeptide. Therefore, this novel high-throughput PGN glycopeptide microarray technology promises to identify distinct antibody profiles against human microbiomes in diseases, notably in those involving the intestine.}, archive = {J_ANGEW}, author = {Alexandra Tsouka and Yanyan Fu and Manuel G. Ricardo and Peter H. Seeberger and Yue Wang and Gerald B. Pier and Detlef Schuppan and Louis Boon and Jan Maarten van Dijl and Maria C. Bolling and Girbe Buist and Felix F. Loeffler and Jon D. Laman}, doi = {10.1002/anie.202420874}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202420874}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthetic high-throughput microarrays of peptidoglycan fragments as a novel sero-diagnostic tool for patient antibody profiling}, volume = {64}, year = {2025}, }
• (2025). Bridging the oxo wall: A new perspective on high-valent metal-oxo species and their reactivity in mn, fe, and co complexes. ANGEW, 64(18), e202419953. (www)

  @article{ , abstract = {The “oxo-wall” is a well-established concept in the area of bioinorganic chemistry, which refers to the instability of the terminal metal-oxo complexes in the +4 oxidation state, with tetragonal C 4v symmetry beyond group 8 elements. This leads to a diverse and highly reactive chemistry of Co-oxo complexes, as evidenced in the literature, ranging from challenging C−H bond activation to efficient water oxidation. Despite extensive research on first-row terminal metal-oxo complexes and the “oxo-wall” concept, studies correlating the reactivity of these species across the periodic table remain scarce. In this work, using a combination of DFT and ab initio CASSCF calculations, we have explored the structure, bonding, and reactivity of [M IV/V (15-TMC)(O)(CH 3 CN)] m+ (M= Mn, Fe and Co) species. Our study reveals several intriguing outcomes: (i) while existing literature typically indicates the presence of either Co IV =O or Co III –O • species beyond the wall, we propose a quantum mechanical mixture of these two species (termed as Co IV =O Co III –O • ), with the per cent of mixing dictated by ligand architecture and symmetry considerations; (ii) we observe that the oxyl radical character increases beyond the wall, correlating with larger N trans -M−O tilt angles; and (iii) we identify an inverse relationship between the percentage of M–O • character and the kinetic barriers for C−H bond activation. These findings offer a new perspective on the roles of oxidation states, spin states, and the nature of the metal ion in reactivity.}, archive = {J_ANGEW}, author = {Asmita Sen and Sunita Sharma and Gopalan Rajaraman}, doi = {10.1002/anie.202419953}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {18}, pages = {e202419953}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bridging the oxo wall: A new perspective on high-valent metal-oxo species and their reactivity in mn, fe, and co complexes}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Reductant-free enantioselective aza-reformatsky reaction enabled by synergistic visible light photocatalysis and lewis acid catalysis. ANGEW, 64(17), e202581762. (www)

  @article{ , archive = {J_ANGEW}, author = {Mingyi Jiang and Zengcheng Yu and Linhan Yang and Fei Wang and Weidi Cao and Xiaohua Liu and Xiaoming Feng}, doi = {10.1002/anie.202581762}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202581762}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Reductant-free enantioselective aza-reformatsky reaction enabled by synergistic visible light photocatalysis and lewis acid catalysis}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Electrochemical redox synergism-enhanced liquid metal locomotion for unrestricted circuit substrate patterning. ANGEW, 64(17), e202581761. (www)

  @article{ , archive = {J_ANGEW}, author = {Yi Fan and Yigang Shen and Wenli Zhang and Guochao Zeng and Tete Liu and Yilan Wang and Shuli Wang and Jing Zheng and Xu Hou}, doi = {10.1002/anie.202581761}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202581761}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Electrochemical redox synergism-enhanced liquid metal locomotion for unrestricted circuit substrate patterning}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Catalyst improved stereoselectivity and regioselectivity control to access completely alternating poly(lactic-co-glycolic acid) with enhanced properties (Angew. chem. int. ed. 17/2025). ANGEW, 64(17), e202506759. (www)

  @article{ , archive = {J_ANGEW}, author = {Xuanhua Guo and Hassan Ahmed and Guangqiang Xu and Qinggang Wang}, doi = {10.1002/anie.202506759}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202506759}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Catalyst improved stereoselectivity and regioselectivity control to access completely alternating poly(lactic-co-glycolic acid) with enhanced properties (Angew. chem. int. ed. 17/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Boosting C─O bond cleavage and reverse water-gas shift activity via enriched in-plane sulfur vacancies in single-layer molybdenum disulfide (Angew. chem. int. ed. 17/2025). ANGEW, 64(17), e202506409. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhiyuan Zheng and Xin Shang and Weijue Wang and Xiaofeng Yang and Xiong Su and Yanqiang Huang}, doi = {10.1002/anie.202506409}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202506409}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Boosting C─O bond cleavage and reverse water-gas shift activity via enriched in-plane sulfur vacancies in single-layer molybdenum disulfide (Angew. chem. int. ed. 17/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Reinventing the high-rate energy storage of hard carbon: The order-degree governs the trade-off of Desolvation–Solid electrolyte interphase at interfaces (Angew. chem. int. ed. 17/2025). ANGEW, 64(17), e202505563. (www)

  @article{ , archive = {J_ANGEW}, author = {Meiqi Liu and Zhou Jiang and Xiangyu Wu and Fuxi Liu and Wenwen Li and Detian Meng and Aofei Wei and Ping Nie and Wei Zhang and Weitao Zheng}, doi = {10.1002/anie.202505563}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202505563}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Reinventing the high-rate energy storage of hard carbon: The order-degree governs the trade-off of Desolvation–Solid electrolyte interphase at interfaces (Angew. chem. int. ed. 17/2025)}, volume = {64}, year = {2025}, }
• (2025). Yao-yao zhang. ANGEW, 64(17), e202504657. (www)

  @article{ , archive = {J_ANGEW}, author = {Yao-Yao Zhang}, doi = {10.1002/anie.202504657}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202504657}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Yao-yao zhang}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Exceptional CO2 hydrogenation to ethanol via precise single-atom ir deposition on functional p islands (Angew. chem. int. ed. 17/2025). ANGEW, 64(17), e202504650. (www)

  @article{ , archive = {J_ANGEW}, author = {Lingyue Liu and Jinjie Liu and Guangchao Li and Xiuwen Shi and Jun Yin and Shourong Zheng and Ka-Fu Yung and Hong Bin Yang and Tsz Woon Benedict Lo}, doi = {10.1002/anie.202504650}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202504650}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Exceptional CO2 hydrogenation to ethanol via precise single-atom ir deposition on functional p islands (Angew. chem. int. ed. 17/2025)}, volume = {64}, year = {2025}, }
• (2025). Heteroatom-assisted regio- and stereoselective hydrosilylation of unsymmetric internal alkynes by scandium catalyst. ANGEW, 64(17), e202502665. (www)

  @article{ , abstract = {The catalytic hydrosilylation of alkynes with hydrosilanes is the most straightforward and atom-efficient method for the synthesis of silylalkenes. However, the hydrosilylation of unsymmetrical internal alkynes often encounters regio- and stereoselectivity challenges. Herein, we report the regio- and syn -stereoselective hydrosilylation of unsymmetrical internal alkynes bearing heteroatom functional groups with hydrosilanes by half-sandwich scandium catalyst. This protocol offers an atom-efficient route for the synthesis of a new family of heteroatom (O, S or N)-functionalized multisubstituted silylalkenes from a variety of internal homopropargyl thioethers, ethers and tertiary amines and hydrosilanes, featuring 100 % atom-efficiency, broad substrate scope, and excellent regio- and syn -stereoselectivity (>19 : 1 r.r. and >19 : 1 syn / anti ). The mechanistic details have been elucidated by control experiments and isolation and examination of some key reaction intermediates. It was revealed that an interaction between the heteroatom (O, S or N) in the internal alkynes and the Sc center was critical for achieving the unprecedented high selectivity.}, archive = {J_ANGEW}, author = {Yuanhong Ma and Aniket Mishra and Tenggang Jiao and Wendi Chang and Shao-Jie Lou and Masayoshi Nishiura and Xuefeng Cong and Zhaomin Hou}, doi = {10.1002/anie.202502665}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202502665}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heteroatom-assisted regio- and stereoselective hydrosilylation of unsymmetric internal alkynes by scandium catalyst}, volume = {64}, year = {2025}, }
• (2025). In situ self-assembly of artificial topological nanostructures enhances in vivo efficacy of PCSK9 inhibitory peptides. ANGEW, 64(17), e202502559. (www)

  @article{ , abstract = {Optimizing the stability and affinity of peptides in vivo is critical for their development as alternatives to approved monoclonal antibodies. In recent years, efforts in academia and industry have focused on modifying Pep2-8, a classical antagonistic peptide targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), to enhance its specificity and affinity. However, developing effective PCSK9 inhibitory peptides remains challenging, especially given the limited examples of their successful in vivo applications. Here, we designed transformable inhibitory peptide (TIP) against PCSK9 based on the modular structure of Pep2-8. Upon encountering PCSK9, TIP undergoes in situ self-assembly at the epidermal growth factor-like domain A (EGF-A) binding domain of PCSK9 to form artificial topological nanostructures (ATNs). The ATNs not only enhance peptide stability and prolong in vivo retention time but also strengthen PCSK9 binding through multivalent synergistic effects. We demonstrate that compared to Pep2-8, TIP forms ATNs which increasing its binding affinity for PCSK9 by approximately 18.7-fold in vitro. In high-fat diet mouse models, TIP significantly increase hepatic LDLR levels (2.0-fold) and reduced LDL-C and TC levels. We envision that the in situ formation of ATNs by peptides enhances in vivo stability and affinity, which offering an approach for development as antibody alternatives in clinical.}, archive = {J_ANGEW}, author = {Qin Li and Zhaode Mu and Yuhan Dong and Zubin Ouyang and Jianli Zuo and Yijie Wu and Yuxuan Yang and Si Sun and Hongwen Liang and Lijuan Bai}, doi = {10.1002/anie.202502559}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202502559}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ self-assembly of artificial topological nanostructures enhances in vivo efficacy of PCSK9 inhibitory peptides}, volume = {64}, year = {2025}, }
• (2025). Direct upcycling of degraded LiCoO2 towards high-performance cathodes via a multifunctional organic lithium salt. ANGEW, 64(17), e202502176. (www)

  @article{ , abstract = {Direct recycling of spent lithium-ion batteries (LIBs) is a promising technology for resource sustainability and environmental conservation. However, the lithium sources for cathode regeneration are typically mono-functional, resulting in low performance enhancement of the recycled material. Herein, we report a one-step direct upcycling method to recycling degraded lithium cobalt oxide (D-LCO) with lithium lignosulfonate (Li−L). Li−L as a multifunctional organic lithium salt can spontaneously attach to the surface of the D-LCO molecules, thus providing replenishment of Li and doping of elemental sodium and sulfur during the regeneration process. Benefiting from the more stable structure of regenerated LCO supported by Na and S elements, the diffusion efficiency of Li ions and electrons can be improved during charging/discharging. As a result, the cell with upcycling LCO cathode exhibits a high capacity of 220.7 mAh g −1 at 0.1 C and retention rate of 89.7 % after 300 cycles at 10 C with a maximum cut-off voltage of 4.6 V. More importantly, life-cycle analysis shows that the upcycling method performs optimally in environmental protection and energy conservation, as well as economic benefits, providing a prospective pathway for the large-scale application of recycling spent batteries.}, archive = {J_ANGEW}, author = {Difan Fang and Feng Wu and Xixue Zhang and Xiaodong Zhang and Yusheng Ye and Renjie Chen and Li Li}, doi = {10.1002/anie.202502176}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202502176}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct upcycling of degraded LiCoO2 towards high-performance cathodes via a multifunctional organic lithium salt}, volume = {64}, year = {2025}, }
• (2025). Broadband-light-induced [2+2] cycloaddition and thermoinduced cycloreversion-powered dynamic molecular crystals. ANGEW, 64(17), e202502107. (www)

  @article{ , abstract = {Photomechanically responsive dynamic molecular crystals are central to developing efficient, rapid, and robust materials capable of conversion of light energy to mechanical work. However, unlike some other, mainly photochromic molecular solar thermal energy storage (MOST) systems, solids that undergo photoinduced [2+2] cycloaddition have not been thoroughly explored for powering reversible actuation, despite that this reaction system carries potential in the heavily strained bonds of the cyclobutane ring. In this study, we propose that broadband-light-induced [2+2] cycloaddition can be used to store energy and actuate dynamic organic crystals by irradiation with visible light. The prototypical material, pyrenylvinylpyrylium tetrafluoroborate ( 1 – PVPyL ), undergoes a topochemical [2+2] cycloaddition induced not only by ultraviolet radiation (365 nm) but also by monochromatic green light (532 nm), red light (620 nm) and broadband visible light in a single-crystal-to-single-crystal (SCSC) manner, causing its crystals to bend. The crystals effectively act as energy depots, where the reverse deformation can be initiated by heating and the stored energy is released via thermal cycloreversion reaction. Given the ubiquity of the [2+2] cycloaddition in the solid state, the current study invites the development of new dimeric MOST architectures that utilize sunlight for energy storage and thermal triggers for energy release. Within a broader scope, this approach provides a platform for fabrication of visible-light-driven crystal actuators capable of harnessing sunlight.}, archive = {J_ANGEW}, author = {Jiangbin Zhong and Jingbo Sun and Chao Chen and Xiqiao Yang and Kaiqi Ye and Liang Li and Panče Naumov and Ran Lu}, doi = {10.1002/anie.202502107}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202502107}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Broadband-light-induced [2+2] cycloaddition and thermoinduced cycloreversion-powered dynamic molecular crystals}, volume = {64}, year = {2025}, }
• (2025). Boosting lithium storage performance of small-molecule organic cathodes through synergistic molecular engineering and nanostructure design. ANGEW, 64(17), e202502088. (www)

  @article{ , abstract = {Small-molecule organic carbonyl compounds (SMOCCs) featuring high theoretical capacities are promising cathodes for lithium-ion batteries (LIBs), but facing challenges in cycling stability and rate performance owing to their high solubility in organic electrolytes and low conductivity. Herein, we propose a novel architecture wherein nanosized SMOCCs with N-heterocycle-extended π-conjugation are uniformly immobilized on reduced graphene oxide (rGO). This approach leverages the N-heterocycles to create additional active sites and strengthen π-π interactions with rGO, while the homogeneous distribution of nanosized SMOCCs on rGO facilitates efficient charge transport and electrolyte infiltration. As a demonstration, we synthesize a composite material using dipyrido[3’,2’:5,6;2′′,3′′:7,8]quinoxalino[2,3-i]dipyrido[3,2-a:2’,3’-c] phenazine-10,21-dione (DQDPD) as the active component, which exhibits remarkable electrochemical properties in LIBs, including an ultrahigh capacity of 505 mAh g −1 at 0.2 A g −1 , exceptional cycle stability with 82 % capacity retention after 3000 cycles at 5 A g −1 , and outstanding rate capability of 290 mAh g −1 at 10 A g −1 . Our approach, which integrates molecular engineering and nanostructure design, provides a novel paradigm for simultaneously realizing high capacity, long lifespan, and rapid rate capability in SMOCCs.}, archive = {J_ANGEW}, author = {Huiling Peng and Yu Han and Lei Zhang and Yaheng Geng and Zehao Yu and Chen Xu and Yizhi Yuan and Zhiqun Zhou and Xiao Liang and Jian Zhu and Zhiqiang Zhu}, doi = {10.1002/anie.202502088}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202502088}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting lithium storage performance of small-molecule organic cathodes through synergistic molecular engineering and nanostructure design}, volume = {64}, year = {2025}, }
• (2025). Chemoselective functionalization of tertiary C−H bonds of allylic ethers: Enantioconvergent access to sec,tert-vicinal diols. ANGEW, 64(17), e202501924. (www)

  @article{ , abstract = {While enantioenriched alcohols are highly significant in medicinal chemistry, total synthesis, and materials science, the stereoselective synthesis of tertiary alcohols with two adjacent stereocenters remains a formidable challenge. In this study, we present a dual catalysis approach utilizing photoredox and nickel catalysts to enable the unprecedented chemoselective functionalization of tertiary allylic C−H bonds in allyl ethers instead of cleaving the C−O bond. The resulting allyl-Ni intermediates can undergo coupling with various aldehydes, facilitating a novel enantioconvergent approach to access extensively functionalized homoallylic sec,tert -vicinal diols frameworks. This protocol exhibits nice tolerance towards functional groups, a broad scope of substrates, excellent diastereo- and enantioselectivity (up to 20 : 1 dr, 99 % ee ). Mechanistic studies suggested that allyl-Ni II acts as the nucleophilic species in the coupling reaction with carbonyls.}, archive = {J_ANGEW}, author = {Yuqing Chen and Xin Wang and Jing-Ran Shan and Zhixian Wu and Renxu Cao and Yonghong Liu and Yunhe Jin and Erjun Hao and K. N. Houk and Lei Shi}, doi = {10.1002/anie.202501924}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemoselective functionalization of tertiary C−H bonds of allylic ethers: Enantioconvergent access to sec,tert-vicinal diols}, volume = {64}, year = {2025}, }
• (2025). Reactivity and magnetic coupling of triangulene dimers linked via para-biphenyl units. ANGEW, 64(17), e202501874. (www)

  @article{ , abstract = {Triangulene and its homologues are promising building blocks for high-spin low-dimensional networks with long-range magnetic order. Despite the recent progress in the synthesis and characterization of coupled triangulenes, key parameters such as the number of organic linking units or their dihedral angles remain scarce, making further studies crucial for an essential understanding of their implications. Here, we investigate the synthesis and reactivity of two triangulene dimers linked by two ( Dimer 1 ) or one ( Dimer 2 ) para -biphenyl units, respectively, on a metal surface in an ultra-high vacuum environment. First-principles calculations and model Hamiltonians reveal how spin excitation and radical character depend on the rotation of the para -biphenyl units. Comprehensive scanning tunneling microscopy (STM) in combination with density functional theory (DFT) calculations confirm the successful formation of Dimer 1 on Au(111). Non-contact atomic force microscopy (nc-AFM) measurements resolve the twisted conformation of the linking para -biphenyl units for Dimer 1 . On the contrary, the inherent flexibility of Dimer 2 induces the planarization of the para -biphenyl, resulting in the spontaneous formation of two additional five-membered rings per dimer connected by a single C−C bond ( Dimers 2′ ). Furthermore, scanning tunneling spectroscopy (STS) measurements confirm the antiferromagnetic (S=0) coupling of the observed dimers, underscoring the critical influence of dihedral angles and structural flexibility of the linking units in π-electron magnetic nanostructures.}, archive = {J_ANGEW}, author = {Elena Pérez-Elvira and Marco Lozano and Qiang Huang and Ji Ma and Aurelio Gallardo and Ana Barragán and Koen Lauwaet and José M. Gallego and Rodolfo Miranda and Pavel Jelínek and David Écija and Diego Soler-Polo and Xinliang Feng and José I. Urgel}, doi = {10.1002/anie.202501874}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501874}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reactivity and magnetic coupling of triangulene dimers linked via para-biphenyl units}, volume = {64}, year = {2025}, }
• (2025). Synergy from the stepped hollow FeHCFe nanocubes and the dimorphic polypyrrole for high-performance electrochemical water desalination. ANGEW, 64(17), e202501797. (www)

  @article{ , abstract = {Saline water desalination serves as an important route to increase freshwater supply, while capacitive deionization (CDI) has emerged as a promising technique to tackle this issue. To boost the successful application of CDI, development of advanced electrode materials is vital. Herein, we innovatively designed and synthesized a sophisticated Prussian blue/dimorphic polypyrrole composite for the hybrid CDI (HCDI). Specifically, the nanoparticle-like polypyrrole (PPy) in situ distributed on the surface of stepped hollow FeHCFe nanocubes, while the coexisting nanotube-like PPy interconnected the discrete stepped hollow FeHCFe nanocubes. The introduction of PPy nanoparticles/nanotubes promoted both electron and ion dynamics, and improved the electrochemical activity of FeHCFe. Meanwhile, the FeHCFe nanocubes with concave stepwise architecture on each side offered large accessible contact area for electrolyte, reduced Na + migration path, improved tolerance for lattice expansion, and optimized redox sites for Na + storage. Through such unique structural design and synergistic combination, the FeHCFe/PPy with appropriate component ratio achieved a remarkable desalination capacity and a fast desalination rate along with excellent cycling performance, outperforming other related materials. Moreover, the treated solution can meet the drinking water standard within 6 min via the use of six tandem HCDI cells. Density functional theory (DFT) revealed the mechanism of Na + capture process and provided a fundamental understanding of the rapid Na + migration and large Na + storage capability. This study provides insights into ration design of superior electrode materials for high-performance electrochemical water desalination.}, archive = {J_ANGEW}, author = {Yu Liu and Kunyue Luo and Wenle Xing and Wenjun Yin and Jing Feng and Shuaishuai Pi and Zixiao Kang and Jie Liang and Lin Tang and Wangwang Tang}, doi = {10.1002/anie.202501797}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501797}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergy from the stepped hollow FeHCFe nanocubes and the dimorphic polypyrrole for high-performance electrochemical water desalination}, volume = {64}, year = {2025}, }
• (2025). Crystallization thermodynamics regulation of 1.85 eV wide-bandgap perovskite for efficient and stable perovskite-organic tandem photovoltaics. ANGEW, 64(17), e202501764. (www)

  @article{ , abstract = {Wide-band gap perovskite with adjustable band gaps can be integrated with organic solar cells to form tandem solar cells (TSCs), thereby surpassing the Shockley–Queisser limit. However, increasing Br content to elevate the band gap above 1.8 eV complicates crystallization, leading to inferior film quality and defects due to the unmanageable evolution of intermediate phases. Surface passivation improves crystallization but hard to moderate the inhomogeneous component distributions and defects in the bulk phase. Here, we introduce a diammonium salt as an additive to regulate the homogeneity and crystallization of perovskite film, eliminating the low-dimensional intermediate phase for orientated crystallization of 1.85 eV perovskite, resulting in efficient wide-band gap perovskite solar cells with an impressive open-circuit voltage ( V oc ) of 1.379 V and operational stability remaining 85 % of their initial efficiency after illumination for 1200 h. Furthermore, perovskite-organic TSCs achieve a champion power conversion efficiency of 24.03 % and a high V oc of 2.108 V, one of the highest V oc for perovskite-organic TSCs.}, archive = {J_ANGEW}, author = {Guanshui Xie and Huan Li and Jun Fang and Xin Wang and Haichen Peng and Dongxu Lin and Nuanshan Huang and Lin Gan and Wenjia Li and Ruixuan Jiang and Tongle Bu and Fuzhi Huang and Sisi He and Longbin Qiu}, doi = {10.1002/anie.202501764}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501764}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystallization thermodynamics regulation of 1.85 eV wide-bandgap perovskite for efficient and stable perovskite-organic tandem photovoltaics}, volume = {64}, year = {2025}, }
• (2025). An azo polymer with abundant active sites and extended conjugation as a stable cathode for high-performance zinc-organic batteries. ANGEW, 64(17), e202501743. (www)

  @article{ , abstract = {Developing stable cathodes with high capacity and rapid redox kinetics is pivotal for aqueous zinc-organic batteries (ZOBs). A huge challenge lies in balancing the density of active sites and electronic conductivity of organic cathodes. Herein, an azo polymer from 4,5,9,10-pyrene-tetraone (PTAP) possessing high active components and extended conjugated structure was achieved. The extended conjugated system linked by the azo groups facilitates extensive electron delocalization and a low band gap, which endows the PTAP with enhanced electronic conductivity reaching 4.26×10 −3 S m −1 . The azo groups themselves serve as active centers for two-electron transfer, leading to a significant increase in the density of redox-active sites and charge storage efficiency. Moreover, strong intramolecular interactions and unique solvation structure bolster the anti-solubility of PTAP. Consequently, PTAP-based ZOBs exhibited high reversible capacities and rate performance, delivering 442.45 mAh g −1 at 0.2 A g −1 and maintaining 248.61 mAh g −1 even at 10 A g −1 . Additionally, a ZOB showed remarkable long-term stability after cycling over 900 hours at 5 A g −1 . Mechanistic studies further revealed that multi-step coupling of carbonyl and azo groups accompanied by the Zn 2+ /H + dual-ion insertion is responsible for rapid 12-electron transfer in PTAP. This work provides new insight into the rational design of advanced organic cathodes for high capacity and long life ZOBs.}, archive = {J_ANGEW}, author = {Chengwei Ye and XiaoYa Zhou and Shaochun Tang}, doi = {10.1002/anie.202501743}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501743}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An azo polymer with abundant active sites and extended conjugation as a stable cathode for high-performance zinc-organic batteries}, volume = {64}, year = {2025}, }
• (2025). “Self-catalysis” acceleration of carrier transport in one-dimensional covalent organic frameworks with mortise-tenon stacking. ANGEW, 64(17), e202501614. (www)

  @article{ , abstract = {Covalent Organic Frameworks (COFs) are promising in the field of photonic energy conversion. However, most efforts have been concentrated on the design of ligand geometric structures and chemical bonding relationships, while understanding the impact of stacking methods on photonic energy conversion remains a significant challenge. In this work, four COFs (1D-COF, 1D-MeCOF, 1D- t BuCOF and 2D-COF) with the same main-chain structure but different stacking methods are designed and synthesized, using photocatalytic hydrogen evolution as a model reaction. Mortise-tenon stacked 1D-MeCOF exhibits far superior photocatalytic hydrogen evolution performance to other stacking methods, and it maintains high efficiency and stability in natural seawater systems. Extensive characterization demonstrates that such a unique mortise-tenon stacking structure of 1D-MeCOF inhibits interchain slippage, enhances π-stacking, and maximizing light absorption capabilities. Furthermore, unidirectional carrier transport characteristics of one-dimensional structure can generate a strong photo-induced self-built electric field, which acts as “self-catalysis” to accelerate carrier transport. This work provides an effective design strategy and mechanistic insights on the stacking engineering of photonic energy conversion materials.}, archive = {J_ANGEW}, author = {Zhe Zhang and Yuxin Liu and Yuhang Qi and Zhuochen Yu and Xiao-bo Chen and Chunguang Li and Zhan Shi and Shouhua Feng}, doi = {10.1002/anie.202501614}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501614}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Self-catalysis” acceleration of carrier transport in one-dimensional covalent organic frameworks with mortise-tenon stacking}, volume = {64}, year = {2025}, }
• (2025). Synthesis of NIR-II fluorophores by a C(sp2)−C(sp2/sp) coupling reaction driven by charge-transfer interaction. ANGEW, 64(17), e202501566. (www)

  @article{ , abstract = {Here, we report a C(sp 2 )−C(sp 2 /sp) coupling reaction driven by charge transfer interaction. Due to the strong intermolecular noncovalent interaction, an essential electron donor-acceptor (EDA) complex is formed, confirmed solidly by absorption spectra, 1 H NMR and single crystal X-ray diffraction. The EDA complex lowers the activation barrier ( E a =9.17 kcal/mol) and facilitates the formation of the C−C bond, which is the rate-limiting step revealed by H/D and 12 C/ 13 C KIE studies. Kinetic investigations reveal that the reaction is a second-order reaction. Furthermore, high-level theoretical calculations support the proposed mechanism. The mono- and di-substituted products were obtained by varying the reaction conditions. A series of structurally diverse and novel second near-infrared (NIR-II) fluorophores based on benzo[1,2-c : 4,5-c’]bis([1,2,5]thiadiazole) (BBTD) were synthesized by utilizing this coupling reaction.}, archive = {J_ANGEW}, author = {Jie Li and Xin-Xin Liu and Ling-Ya Peng and Li-Ya Niu and Wenguang Wang and Ganglong Cui and Qing-Zheng Yang}, doi = {10.1002/anie.202501566}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501566}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of NIR-II fluorophores by a C(sp2)−C(sp2/sp) coupling reaction driven by charge-transfer interaction}, volume = {64}, year = {2025}, }
• (2025). Linkage microenvironment and oxygen electroreduction reaction performance correlationship of iron phthalocyanine-based polymers. ANGEW, 64(17), e202501506. (www)

  @article{ , abstract = {Iron phthalocyanine-based conjugated polymers (PFePc) offer well-defined sites, rendering them ideal model systems to elucidate structure–property relationships towards oxygen reduction reaction (ORR), but have struggled to achieve improved catalytic activity due to uniform electron distribution of iron center and difficulty in molecular-level structure design. Although rationally linkage microenvironmental regulation is an effective approach to adjusting activity, the underlying fundamental mechanism is incompletely understood. Herein, systematic DFT calculations and experimental investigation of PFePc analogous reveal that the incorporation of the electron-withdrawing benzophenone linkage into the PFePc backbone (PFePc-3) drives the delocalization of Fe d -orbital electrons, downshifts the d -band energy level, thereby tailoring the key OH* intermediate interaction, demonstrating enhanced ORR performance with a half-wave potential of 0.91 V, a high mass activity of 21.43 A g −1 , and a high turnover frequency of 2.18 e s −1 site −1 . Magnetic susceptibility measurements and electron paramagnetic resonance spectroscopy reveal that linkage regulation can induce a 3 d electron with high spin-state (t 2g 3 e g 2 ) of PFePc-3, significantly accelerating the ORR kinetics. In situ scanning electrochemical microscopy and variable-frequency square wave voltammetry further highlight the rapid kinetics of PFePc-3 to the high accessible site density (6.14×10 19 site g −1 ) and fast electron outbound propagation mechanism.}, archive = {J_ANGEW}, author = {Mingtao Huang and Qiao Gu and Yonggan Wu and Yuanhao Wei and Yangfan Pei and Ting Hu and Dirk Lützenkirchen-Hecht and Kai Yuan and Yiwang Chen}, doi = {10.1002/anie.202501506}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501506}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Linkage microenvironment and oxygen electroreduction reaction performance correlationship of iron phthalocyanine-based polymers}, volume = {64}, year = {2025}, }
• (2025). Weakening solvent-solute interactions for high-efficiency screen-printed perovskite solar cells. ANGEW, 64(17), e202501350. (www)

  @article{ , abstract = {Screen printing has emerged as a leading candidate for industrial-scale fabrication of perovskite photovoltaics. However, strong solvent-solute interaction in conventional formulations accelerates the preferential crystallization of perovskites at points, hindering the progressive phase evolution from point to line to plane. In this work, we introduced halogen ions to weaken solvent-solute interactions, achieving the reduced Pb⋅⋅⋅O coordination strength counterbalanced by enhanced Pb−I bonding interactions. This weakened interaction delays formamidinium iodide participation in rapid phase transitions to α-formamidinium lead iodide, enabling controlled crystallization kinetics. The optimized screen-printed perovskite solar cells demonstrate remarkable power conversion efficiencies (PCE) of 21.8 % for 0.05 cm 2 devices and 18.95 % for 5 cm×5 cm mini-modules (active area: 12.60 cm 2 ). Furthermore, this strategy exhibits broad process compatibility, achieving 23–24 % PCEs for both blade-coating and spin-coating devices fabricated under ambient conditions (25–30 °C, 35–50 % relative humidity). These breakthroughs highlight the universal potential of coordination engineering for scalable perovskite photovoltaics.}, archive = {J_ANGEW}, author = {Qing Yao and Zihan Gu and Changshun Chen and Yuan Jiang and Zhenhuang Su and Jinpei Wang and Tingting Niu and Tengfei Pan and Yingdong Xia and Lirong Zheng and Xingyu Gao and Jing Zhang and Xiaozheng Duan and Lingfeng Chao and Yonghua Chen}, doi = {10.1002/anie.202501350}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Weakening solvent-solute interactions for high-efficiency screen-printed perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Dual defects-induced iron single atoms immobilized in Metal–Organic framework-derived hollow BiOBr microtubes for low-barrier photocatalytic nitrogen reduction. ANGEW, 64(17), e202501297. (www)

  @article{ , abstract = {The rational design of single-atom catalysts with precise coordination environment and high separation efficiency of photogenerated carriers is critical yet challenging to achieve efficient photocatalytic nitrogen reduction. Herein, we design and construct a defective photocatalyst featuring Fe single atoms immobilized in hollow BiOBr microtube using a plasma-assisted synthesis strategy, where the Bi-based metal–organic framework is used as sacrificial template. The dual vacancies of oxygen (V O ) and bromine (V Br ) are created in the BiOBr microtube and induce the formation of coordinatively unsaturated FeO 5 configuration, where four oxygen atoms are from [Bi 2 O 2 ] 2+ units and one oxygen atom is located in the V Br . Specially, the hollow catalyst with dual defects and FeO 5 moiety exhibits 1.4 and 2.2 times higher ammonia production activity than another two V Br -featuring catalysts with coordinatively saturated FeO 6 configuration and unsaturated FeO 4 configuration, respectively. As revealed by experimental and theoretical calculation results, the optimized catalyst with the FeO 5 configuration reduces the energy barrier of electron transfer from Fe 3d orbitals to antibonding orbitals of N 2 molecules, which favors the formation of a key *NNH intermediate in the N 2 fixation reaction and the resultant efficient ammonia production.}, archive = {J_ANGEW}, author = {Xiaosong Wang and Rong Gao and Guilan Fan and Yan Guo and Chenhui Han and Yuliang Gao and Ao Shen and Limin Wu and Xiaojun Gu}, doi = {10.1002/anie.202501297}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501297}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual defects-induced iron single atoms immobilized in Metal–Organic framework-derived hollow BiOBr microtubes for low-barrier photocatalytic nitrogen reduction}, volume = {64}, year = {2025}, }
• (2025). Improving light-responsive efficiency of type II porous liquid by tailoring the functionality of host. ANGEW, 64(17), e202501191. (www)

  @article{ , abstract = {Light-responsive porous liquids (LPLs) attract significant attention for their controllable gas uptake under light irradiation, while their preparation has remained a great challenge. Here we report the fabrication of type II LPLs with enhanced light-responsive efficiency by tailoring the host's functionality for the first time. The functionality of light-responsive metal-organic cage (MOC-RL, constructed from dicopper and responsive ligands) is modified by introducing the second long-chain alkyl ligand, producing MOC-RL-AL as a new host. A spatially hindered solvent based on polyethylene glycol, IL-NTf 2 , is designed and can dissolve MOC-RL-AL due to the suitable interaction, creating a type II LPL (PL-RL-AL). Under light irradiation, the variation in propylene adsorption for PL-RL-AL increases by 58.0 % compared to PL-RL. The enhanced light-responsive efficiency is caused by easier control in accessibility of internal cavities within MOCs and increased number of external cavities between MOCs and IL-NTf 2 . This makes PL-RL-AL the first LPL with the probability for propylene/propane separation.}, archive = {J_ANGEW}, author = {Yang Liu and Han-Yan Jin and Meng-Meng Li and Mingrui Zuo and Manish Kumar Dinker and Jiahui Kou and Juntao Yan and Lifeng Ding and Lin-Bing Sun}, doi = {10.1002/anie.202501191}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202501191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving light-responsive efficiency of type II porous liquid by tailoring the functionality of host}, volume = {64}, year = {2025}, }
• (2025). Elucidating the biosynthesis and function of an autoinducing peptide in clostridium acetobutylicum. ANGEW, 64(17), e202500904. (www)

  @article{ , abstract = {Clostridia produce autoinducing peptides (AIPs) regulated by the accessory gene regulator (Agr) quorum sensing system, playing a critical role in intercellular communication. However, the biosynthetic pathway and regulatory functions of clostridial AIPs remain inadequately characterized. In this study, we employed chemical quantification, genetic investigations, and in vitro reconstitution experiments to elucidate the native Ca -AIP in Clostridium acetobutylicum , a prominent industrial producer of acetone, butanol, and ethanol. Our findings identified a signal peptidase (Cac1760) and two CAAX metalloproteases (Cac0077 and Cac2478) as key players in N-terminal cleavage, while AgrB was found to be essential for C-terminal processing during Ca -AIP biosynthesis. Notably, overexpression of agrBD led to a 4.4-fold enhancement in Ca -AIP formation, which corresponded with an increase in butanol production from 12.5 to 14.9 g/L, while preserving vegetative cell morphology. The direct involvement of Ca -AIP in both butanol production and maintenance of cell morphology was further validated through exogenous supplementation. Collectively, these results provide novel insights into the biosynthesis of AIPs and propose a promising strategy for optimizing microbial processes in industrial applications.}, archive = {J_ANGEW}, author = {Chao Zhu and Zixuan Wang and Xiaoyu Zhou and Youduo Wu and Wei Kang and Ren'an Wu and Chuang Xue}, doi = {10.1002/anie.202500904}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500904}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elucidating the biosynthesis and function of an autoinducing peptide in clostridium acetobutylicum}, volume = {64}, year = {2025}, }
• (2025). Defect imide double antiperovskites AE5AsPn(NH)2 (AE=Ca, sr; Pn=Sb, bi) as potential solar cell absorber materials. ANGEW, 64(17), e202500768. (www)

  @article{ , abstract = {An abundance of oxide, halide and chalcogenide perovskites have been explored, demonstrating outstanding properties, while the emerging nitride perovskites are extremely rare due to their challenging synthesis requirements. By inverting the ion type in the perovskite structure, the corresponding antiperovskite structure is obtained. Among them, ternary antiperovskite nitrides X 3 A N ( X =Ba, Sr, Ca, Mg; A =As, Sb) have recently been identified as exhibiting excellent optoelectronic properties. To explore the unrealized composition space of nitride perovskites, the ammonothermal method was applied, yielding three new layered quaternary imide-based defect-antiperovskites, namely AE 5 As Pn (NH) 2 ( AE =Ca, Sr; Pn =Sb, Bi). These new compounds feature distorted square-pyramidal coordination around the imide-group (Ca 5 NH). Layers with Ca 2+ vacancies are found with an alternating As 3− and Pn 3− ( Pn 3− =Sb 3− , Bi 3− ) coordination along the A -site, forming a two-dimensional (2D) structure. All three AE 5 As Pn (NH) 2 compounds show suitable direct band gaps within the visible light spectrum. Density functional theory calculations reveal favorable band dispersion, as well as transport and optical properties, especially along the out-of-plane direction, demonstrating their 3D character of electronic transport. The narrow tunable direct band gaps and favorable charge carrier properties make AE 5 As Pn (NH) 2 promising candidates for solar cell absorber materials.}, archive = {J_ANGEW}, author = {Thanh G. Chau and Dan Han and Florian Wolf and Stefan S. Rudel and Yuxuan Yao and Harald Oberhofer and Thomas Bein and Hubert Ebert and Wolfgang Schnick}, doi = {10.1002/anie.202500768}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500768}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Defect imide double antiperovskites AE5AsPn(NH)2 (AE=Ca, sr; Pn=Sb, bi) as potential solar cell absorber materials}, volume = {64}, year = {2025}, }
• (2025). Reductant-free enantioselective aza-reformatsky reaction enabled by synergistic visible light photocatalysis and lewis acid catalysis. ANGEW, 64(17), e202500756. (www)

  @article{ , abstract = {Classical aza -Reformatsky reaction generally involves excess reductants. Herein, we developed a visible light-induced catalytic asymmetric aza -Reformatsky reaction via a chiral Lewis acid-assisted direct excitation of imines without additional reductants, enabling the carbon–iodine bond cleavage of iododifluoromethyl ketones and the subsequent enantioselective radical coupling. This protocol provided an ingenious access to chiral β -amino ketones containing a gem -difluorine moiety. The mechanistic studies including radical trapping experiment, NMR experiment, electron paramagnetic resonance experiment, cyclic voltammetry experiment and spectroscopic analysis rationalized the reaction process.}, archive = {J_ANGEW}, author = {Mingyi Jiang and Zengcheng Yu and Linhan Yang and Fei Wang and Weidi Cao and Xiaohua Liu and Xiaoming Feng}, doi = {10.1002/anie.202500756}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500756}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reductant-free enantioselective aza-reformatsky reaction enabled by synergistic visible light photocatalysis and lewis acid catalysis}, volume = {64}, year = {2025}, }
• (2025). Water-resistant organic room-temperature phosphorescence from block copolymers. ANGEW, 64(17), e202500610. (www)

  @article{ , abstract = {Room-temperature phosphorescence (RTP) polymers have demonstrated significant potential for various applications due to their unique luminescent properties. However, most conventional RTP polymers are vulnerable to moisture and water, which can disrupt the hydrogen bonding network within the polymer and accelerate the non-radiative decay of triplet excitons of phosphors, leading to the quenching of RTP. Herein, we present a universal strategy to achieve water-resistant RTP polymers by designing amphiphilic block copolymers with microphase-separated structures. Specifically, the rigid hydrophilic phase, which is rich in carboxyl groups, forms hydrogen bonds that suppress non-radiative decay of the chromophores, resulting in RTP. Meanwhile, the hydrophobic phase effectively prevents water molecules from penetrating and disrupting the rigid polymer network. By combining the functions of both the hydrophilic and hydrophobic phases, the resulting RTP copolymers exhibit good water-resistant properties. Even after being immersed in water for one month, the copolymers maintain a green afterglow with a lifetime of 629 ms. Moreover, the water-resistant nature of these RTP polymers has also been demonstrated in potential applications of afterglow displays and anti-counterfeiting. This research offers valuable insights into the design of RTP materials with stability in aqueous environments and broadens the scope of their potential applications in diverse settings.}, archive = {J_ANGEW}, author = {Huan Chen and Yuanyuan Zhang and Jingyi Shan and Mengyang Dong and Zhao Qian and Anqi Lv and Hu-Jun Qian and Huili Ma and Zhongfu An and Long Gu and Wei Huang}, doi = {10.1002/anie.202500610}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500610}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Water-resistant organic room-temperature phosphorescence from block copolymers}, volume = {64}, year = {2025}, }
• (2025). Oxygen-coordinated cr single-atom catalyst for oxygen reduction reaction in proton exchange membrane fuel cells. ANGEW, 64(17), e202500500. (www)

  @article{ , abstract = {Carbon-supported metal single-atom catalysts (M-SACs) are promising oxygen reduction reaction (ORR) catalysts. Their ORR activity and selectivity are significantly affected by the heteroatoms that coordinate the central metal atoms. Previous reports found that oxygen-coordinated M-SACs promoted a 2e − ORR rather than the 4e − ORR that is more desirable for fuel cells. Herein, we report for the first time that oxygen-coordinated M-SACs are capable of promoting the 4e − ORR in acid media. We prepared a Cr(acac)-NC catalyst with the central Cr atom coordinated by two O atoms. The Cr(acac)-NC catalyst not only exhibits excellent ORR activity and stability in acid media, but also delivers high proton exchange membrane fuel cell (PEMFC) performance comparable to N-coordinated M-SACs. Density functional theory (DFT) calculations reveal that Cr−O2 moieties located on the zigzag edge of the carbon support are the ORR-active sites.}, archive = {J_ANGEW}, author = {Junming Luo and Yating Zhang and Zhe Lu and Chao Liu and Yueshan Xu and Hui Chen and Qi Wang and Daoxiong Wu and Dai Dang and Yijie Deng and Peng Rao and Peilin Deng and Jing Li and Zhengpei Miao and Xinlong Tian}, doi = {10.1002/anie.202500500}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500500}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen-coordinated cr single-atom catalyst for oxygen reduction reaction in proton exchange membrane fuel cells}, volume = {64}, year = {2025}, }
• (2025). Temperature-inert weakly solvating electrolytes for low-temperature lithium-ion batteries with micro-sized silicon anodes. ANGEW, 64(17), e202500367. (www)

  @article{ , abstract = {Cost-effective micro-sized silicon (μSi) anodes with high specific capacity are promising for high-energy-density lithium-ion batteries but face significant volume changes during cycling. Constructing anion-derived, inorganic-rich solid-electrolyte interphase by electrolyte engineering is considered a viable strategy for stabilizing μSi anodes. However, at low temperatures, temperature-dependent anion-dominated solvation and sluggish Li + desolvation hinder cyclability and capacity retention. Here we introduce a unique temperature-inert weakly solvating electrolyte (TIWSE) that preserves the anion-dominated solvation sheath and has weak solvent coordination capability, enabling stable cycling of μSi anodes in subzero environments. The crucial role of NO 3 − anions with a high donor number in regulating competitive coordination in TIWSE is unveiled. As a result, μSi||LiNi 0.8 Co 0.1 Mn 0.1 O 2 full cells with TIWSE demonstrate impressive capacity retention of 91.8 % at −20 °C and 80.8 % at 30 °C after 100 cycles, along with a high specific capacity of 137.4 mAh g −1 at 6 C. Furthermore, a 1-Ah pouch cell of Si−C||LiNi 0.8 Co 0.1 Mn 0.1 O 2 shows remarkable cycling stability with 89.3 % capacity retention over 300 cycles at 30 °C and 77.3 % retention at −20 °C, demonstrating the practical applicability. This work highlights the importance of solvation chemistry in addressing low-temperature challenges and offers new insights into high-energy μSi-based lithium-ion batteries operating under harsh conditions.}, archive = {J_ANGEW}, author = {Xiaoyu Sang and Kangjia Hu and Jiaxin Chen and Zhangci Wang and Henghui Xu and Yunhui Huang and Xianluo Hu}, doi = {10.1002/anie.202500367}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500367}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Temperature-inert weakly solvating electrolytes for low-temperature lithium-ion batteries with micro-sized silicon anodes}, volume = {64}, year = {2025}, }
• (2025). A versatile strategy to transform cationic polymers for efficient and organ-selective mRNA delivery. ANGEW, 64(17), e202500306. (www)

  @article{ , abstract = {The progress of mRNA therapeutics underscores the imperative demand for the development of targeted delivery systems. While cationic polymers hold promise as genetic vectors, their poor in vivo efficacy and numerous variants highlight the urgent need for a universal functionalization strategy to bolster their delivery capabilities. Here, we present a versatile strategy to transform low-cost commercial cationic polymers into phospholipidated and alkylated polymers (PAPs), enabling efficient and organ-selective mRNA delivery in vivo. This straightforward post-functionalization method can be readily broadened to a diverse array of existing cationic polymers, enhancing their cellular uptake, endosomal escape, and mRNA release functionalities. Consequently, PAPs facilitate up to 30,500-fold higher mRNA expression compared to their unmodified counterparts in vivo. Notably, the one-component PAPs enable spleen-specific mRNA delivery, with their vaccine application validated in a mouse melanoma model following intravenous administration. Better still, PAPs can synergize with different helper lipids to formulate four-component lipid nanoparticles (LNPs), achieving respective lung- and liver-specific mRNA delivery. Noteworthy is that these organ-selective mRNA delivery systems significantly outperform previous polymer and LNP benchmarks. This transformation strategy for cationic polymers represents a generalized methodology to give highly effective mRNA carriers, highlighting substantial potential for clinical translation of mRNA therapies with organ-targeting requirements.}, archive = {J_ANGEW}, author = {Lixin Lin and Kexin Su and Xinyue Zhang and Lu Shi and Xinxin Yan and Qiuli Fu and Ke Yao and Daniel J. Siegwart and Shuai Liu}, doi = {10.1002/anie.202500306}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500306}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A versatile strategy to transform cationic polymers for efficient and organ-selective mRNA delivery}, volume = {64}, year = {2025}, }
• (2025). Multichannel photon stimulated C−C coupling for CO2 reduction in a mixed Water/Acetonitrile solvent. ANGEW, 64(17), e202500270. (www)

  @article{ , abstract = {Designing effective photocatalysts for carbon dioxide reduction reaction (CO 2 RR) requires a precise understanding of the dynamically photocatalytic mechanism under real conditions (e.g. solvent, light field). Herein, we coupled ab-initio non-adiabatic molecular dynamics (NAMD) simulation and density functional theory (DFT) calculation to theoretically reveal the detailed dynamic process for C−C Coupling under light field on Co-supported monolayer black phosphorus (BP) catalyst Co@BP. Specially, Co@BP features excellent property for photocatalyst: high stability, long-lived photogenerated carriers and stronger reducing ability. Thermodynamically, it shown that a dramatic difference in catalytic properties with 99.99 % selectivity for HCOOH in solvent-free condition ( E a =0.29 eV) and 99.34 % selectivity for CH 2 CH 2 in solution ( E a =0.33 eV). Slow-growth based MD simulation results uncover that mixed solvent of water/acetonitrile (H 2 O/ACN) is beneficial for the formation of C 2+ product and the optimal ratio H 2 O/ACN (1 : 9) mixture solvent for the conversion of CO 2 to CH 2 CH 2 . Under light irradiation, we found that multichannel photons enable adsorbed CHO* to couple with CHO species diffusing from nearby active sites, further forming C 2 intermediates in solution. This work highlights the importance of the reaction medium on the photogenerative carrier dynamics and offers a strategy to regulate product selectivity in photocatalytic CO 2 conversion.}, archive = {J_ANGEW}, author = {Fu-Li Sun and Cun-biao Lin and Zhi-rui Luo and Qing Chen and Wen-Xian Chen and Gui-Lin Zhuang}, doi = {10.1002/anie.202500270}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500270}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multichannel photon stimulated C−C coupling for CO2 reduction in a mixed Water/Acetonitrile solvent}, volume = {64}, year = {2025}, }
• (2025). Atomic-level elucidation of lattice-hydrogens in copper catalysts for selective CO2 electrochemical conversion toward c2 products. ANGEW, 64(17), e202500191. (www)

  @article{ , abstract = {Copper is the most efficient and practical electrocatalyst for the electrochemical reduction of carbon dioxide (ECR) to give multicarbon (C 2+ ) products, but the mechanism by which such products are formed – though known to involve lattice-hydrogens – remains elusive, and the selectivity of the reaction is poor. Herein, we report the synthesis of [AuCu 24 (dppp) 6 H 22 ] + , a copper hydride nanocluster bearing exposed Cu 3 H 3 units in specific surface cavities, and our use of it to study the mechansim and selectivity of the reduction of CO 2 to C 2+ products. Results of in situ infrared spectroscopy and theoretical calculations showed that these Cu 3 H 3 units can effectively lower the energy barrier to the formation of the *COCOH intermediate, which allowed the competition between the C 1 and C 2 pathways to be elucidated. Isotope labeling experiments and catalyst recrystallization studies corroborated the theoretical simulations, identifying the lattice-hydrogen (H − ) in the Cu 3 H 3 active unit as being indispensable for the formation of C 2 H 4 . The molecular design guidelines which this work has facilitated constitute a new approach towards the of copper-based catalysts that convert CO 2 to C 2+ products based on lattice-hydrogen engineering.}, archive = {J_ANGEW}, author = {Xiaoshuang Ma and Cong Fang and Mei Ding and Yang Zuo and Xiaoyan Sun and Shuxin Wang}, doi = {10.1002/anie.202500191}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic-level elucidation of lattice-hydrogens in copper catalysts for selective CO2 electrochemical conversion toward c2 products}, volume = {64}, year = {2025}, }
• (2025). Polycyclic aromatic hydrocarbons with a boron-doped Zigzag/Armchair topology: A boron-edging strategy for organic narrowband emitters. ANGEW, 64(17), e202500110. (www)

  @article{ , abstract = {Control over molecular topologies and/or heteroatom doping of polycyclic aromatic hydrocarbons (PAHs) may alter their electronic structures and achieve desirable physical properties. Herein, this work challenges boron-doping and edge-transformation of π-extended PAHs. We successfully synthesized a series of large-size PAHs featuring a boron-doped zigzag/armchair edge topology through one-pot multifold Scholl cyclization reaction. Two of them possess the desired C 3 -symmetric and unexpected unsymmetrical C 54 B 3 nanographene frameworks, respectively, thus illustrating triply boron-edging manipulations of hexa- peri -hexabenzocoronene. Detailed studies reveal that such boron-doped edge topology significantly inhibits their excited-state molecular vibrations and thereby produces narrowband emission characteristics. The full width at half maximum (FWHM) values of their fluorescence spectra are as small as 12–18 nm, which have never been observed for pristine boron-doped π-system and are among the smallest values reported for organic emitters. Their solution-processed organic light-emitting diodes (OLEDs) display extremely narrowband electroluminescence, and additionally, the obtained FWHM of only 23 nm represents the narrowest one reported for red OLEDs.}, archive = {J_ANGEW}, author = {Xinyu Tian and Zengming Fan and Zeyi Li and Shitong Zhang and Zhiqiang Li and Xuming Zhuang and Yue Wang and Chuandong Dou}, doi = {10.1002/anie.202500110}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500110}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polycyclic aromatic hydrocarbons with a boron-doped Zigzag/Armchair topology: A boron-edging strategy for organic narrowband emitters}, volume = {64}, year = {2025}, }
• (2025). Enhanced cathode-electrolyte interphase for prolonged cycling stability of aluminum-selenium batteries using locally concentrated ionic liquid electrolytes. ANGEW, 64(17), e202500041. (www)

  @article{ , abstract = {Al−Se batteries (ASeBs) with high theoretical specific capacity and discharge voltage are promising energy storage devices. However, the detrimental shuttle effect occurring in conventional ionic liquid electrolytes (ILEs) challenges their development. Herein, a thicker cathode/electrolyte interphase (CEI) is constructed via employing locally concentrated IL electrolytes (LCILEs) to overcome these issues. It is demonstrated that LCILEs facilitate the incorporation of Emim + into the electrode/electrolyte interphases, and, meanwhile, more Al−Cl species deposits are observed in the CEI. The formed CEI effectively prevents the dissolution of poly-selenides, inhibiting their related parasitic reactions. These result in ASeBs, employing the LCILE, to deliver a specific discharge capacity of 218 mAh g −1 at 0.5 A g −1 after 100 cycles at 20 °C, while the cell using the neat ILE only maintains 38 mAh g −1 under the same conditions. Moreover, an Al−S cell operated in LCILEs reaches 578 mAh g −1 at 0.1 A g −1 after 150 cycles, which is also significantly better than 317 mAh g −1 in the neat ILE. This study provides an LCILE-based strategy to reinforce the CEI in order to suppress the shuttle effect, realizing Al-chalcogen batteries with better performance.}, archive = {J_ANGEW}, author = {Cheng Xu and Thomas Diemant and Shuting Zhang and Xu Liu and Stefano Passerini}, doi = {10.1002/anie.202500041}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202500041}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced cathode-electrolyte interphase for prolonged cycling stability of aluminum-selenium batteries using locally concentrated ionic liquid electrolytes}, volume = {64}, year = {2025}, }
• (2025). A nanotherapeutic agent for synergistic tumor therapy: Co-activation of photochemical-biological effects. ANGEW, 64(17), e202425631. (www)

  @article{ , abstract = {Single-mode photodynamic therapy (PDT) based on photochemical reactions is limited by the tumor microenvironment, which reduces the ablation efficiency for solid tumors. Making it vital to seek ways to improve the tumor therapeutic effect. Based on this, we propose a dual-mode intelligent nanotherapeutic system (HAP@BMPns) based on photochemical-biological effects. HAP@BMPns is composed of an acid-responsive high-calcium biomimetic nanomaterial (HAP) and photosensitizer (BMP), which can spontaneously activate photochemical (Type-I PDT) and biological effects for synergistic cancer therapy. HAP@BMPns breaks down upon entering tumor cells under acidic conditions, releasing a large amount of Ca 2+ and BMP. Triggering intracellular Ca 2+ overload, which induces mitochondrial damage, leading to apoptosis. Synchronously, Type-I PDT of BMP under two-photon (800 nm) laser irradiation becomes activated, resulting in enhanced destruction of tumor cells by the photochemical effect. Cell studies have indicated that HAP@BMPns (41.6 μg/mL) exhibits a strong inhibitory efficiency on tumor cells growth, with low (22.4 %) survival rate. However, the individual components, i. e. BMP (5.0 μM) and HAP (41.6 μg/mL) display low inhibitory efficiency with high survival rates (55.9 % and 63.0 % respectively). Therefore, this dual-mode synergistic treatment strategy using acid-triggered photochemical-biological effects significantly enhances the ablation of solid tumors, realizing the synergistic effect. We hope that this design strategy can provide guidance for the design and development of a tumor therapeutic platform.}, archive = {J_ANGEW}, author = {Junwei Liu and Yang Liu and Songsong Zhi and Yonggang Yang and Heejeong Kim and Dapeng Wu and Ge Wang and Tony D. James and Juyoung Yoon and Hua Zhang}, doi = {10.1002/anie.202425631}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202425631}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A nanotherapeutic agent for synergistic tumor therapy: Co-activation of photochemical-biological effects}, volume = {64}, year = {2025}, }
• (2025). Unlocking enhanced catalysis stability in acidic oxygen evolution: Structural insights for PEM applications under high-current density. ANGEW, 64(17), e202425569. (www)

  @article{ , abstract = {In proton exchange membrane water electrolysis (PEMWE), catalysts for acidic oxygen evolution reaction (OER) that demonstrate high current density and stability are essential. Herein, we synthesized La-doped RuO 2 (La-RuO 2 @TM) nanorod composite catalysts in situ on titanium mesh (TM) using a one-step low-temperature pyrolysis method. La-RuO 2 @TM displays excellent catalytic performance (1.533 V at 100 mA cm −2 ) and remarkable stability, showing no significant degradation in performance over 450 hours of operation. Density functional theory (DFT) calculations indicate that the formation of the La-O−Ru local structure modulates the adsorption strength of reaction intermediates, alleviates metal (Ru) leaching, and reduces oxygen loss, significantly enhancing the material‘s durability in acidic OER. The PEM electrolyzer utilizing La-RuO 2 @TM operates at 1.815 V with a current density of 1.0 A cm −2 , maintaining stable performance for 120 h at 60 °C. This study offers valuable insights for designing efficient and durable acidic OER catalysts.}, archive = {J_ANGEW}, author = {Xin-Yi Zhang and Hang Yin and Cong-Cong Dang and Hong Nie and Zhi-Xiong Huang and Shuo-Hang Zheng and Miao Du and Zhen-Yi Gu and Jun-Ming Cao and Xing-Long Wu}, doi = {10.1002/anie.202425569}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202425569}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking enhanced catalysis stability in acidic oxygen evolution: Structural insights for PEM applications under high-current density}, volume = {64}, year = {2025}, }
• (2025). Reinventing the high-rate energy storage of hard carbon: The order-degree governs the trade-off of desolvation-solid electrolyte interphase at interfaces. ANGEW, 64(17), e202425507. (www)

  @article{ , abstract = {In alkali metal-ion battery systems, the electrolyte enables being decomposed on the electrode surface to form a solid electrolyte interphase (SEI) film. In principle, a thin, uniform SEI film facilitates the enhancement of the performance of the cell. Herein, we successfully distinguish the effects of desolvation behavior and SEI process on the kinetic behavior of hard carbon (HC) electrodes by adopting the strategy of switching the electrolyte interface model to modulate the properties of SEI film. Our findings reveal that although the SEI film is generally responsible for significantly affecting the HC's capacity, the equally crucial desolvation process must not be overlooked. The trade-off between the two factors is found to be determined by the structural features of HCs. Specifically, in the context of a more ordered HC, the desolvation of ions emerges as the rate-limiting step for Na + transport across the electrode/electrolyte interface, exerting a more pronounced effect rather than the SEI. Thus, a close correlation was established between the SEI, solvation structure effects, hard carbon structure, and electrode performance. This linkage is thereof fundamental for the strategic design of electrolytes and the targeted enhancement of cell performance.}, archive = {J_ANGEW}, author = {Meiqi Liu and Zhou Jiang and Xiangyu Wu and Fuxi Liu and Wenwen Li and Detian Meng and Aofei Wei and Ping Nie and Wei Zhang and Weitao Zheng}, doi = {10.1002/anie.202425507}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202425507}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reinventing the high-rate energy storage of hard carbon: The order-degree governs the trade-off of desolvation-solid electrolyte interphase at interfaces}, volume = {64}, year = {2025}, }
• (2025). Closed-loop recyclable lithium and sodium conducting covalent adaptable networks. ANGEW, 64(17), e202425497. (www)

  @article{ , abstract = {Within the past two decades, covalent adaptable networks (CANs) have emerged as a novel class of dynamically crosslinked polymers, combining the benefits of thermosets and thermoplastics. Although some CANs with charged side chains have been reported, CANs with negatively charged backbones remain very limited. The integration of permanent charge into the backbones upon their formation could open up important new applications. Here, we introduce a series of aliphatic spiroborate-linked ionic covalent adaptable networks (ICANs), representing a new category of dynamic ionomer thermosets. These ICANs were synthesized using a catalyst-free, scalable, and environment-friendly method. Incorporating lithium or sodium as counter cations in these networks yielded promising ion conductivity without the need of plasticizers. The dynamic nature of the spiroborate linkages in these materials allows for rapid reprocessing and recycling under moderate conditions. Furthermore, their potential as flexible solid-state electrolytes is demonstrated in a device that maintained robust conducting performance under extreme physical deformation, coupled with effective self-healing properties. This research opens new possibilities for future development of dynamic ionomer thermosets and their potential applications in flexible electronic devices.}, archive = {J_ANGEW}, author = {Hongxuan Chen and Lacey J. Wayment and Huan Jiang and Zepeng Lei and Shaofeng Huang and Ashley Ley and Zihao Yue and Zhehao Yuan and Yinghua Jin and Kai Yu and Wei Zhang}, doi = {10.1002/anie.202425497}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202425497}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Closed-loop recyclable lithium and sodium conducting covalent adaptable networks}, volume = {64}, year = {2025}, }
• (2025). σ-π hyperconjugation as a design strategy for high-performance fluorescent covalent organic frameworks. ANGEW, 64(17), e202425436. (www)

  @article{ , abstract = {Realizing efficient solid-state fluorescence in covalent organic frameworks (COFs) represents a persistent and fundamental challenge in materials science, hindering their application in next-generation optoelectronics. Herein, a transformative strategy leveraging σ-π hyperconjugation is introduced to enhance the fluorescence properties of COFs. The incorporation of a methyl group into a pyrene-based COF monomer yields an unprecedented fluorescence quantum yield increase of more than 100-fold, accompanied by significantly enhanced optoelectronic performance. This enhancement arises from σ-π hyperconjugation, which redistributes electron density, converting pyrene from an electron donor to an electron acceptor and facilitating efficient electronic transitions. Additionally, a COF-based fluorescent acoustic sensor, fabricated via electrospinning, demonstrates real-time speech pattern recognition when integrated with machine learning algorithms, showcasing potential in language-assistive technologies. This study pioneers the exploration of hyperconjugation in COFs, offering a new paradigm for the precise modulation of optoelectronic properties and bridging fundamental research with real-world applications.}, archive = {J_ANGEW}, author = {Yin-sheng Liu and Rui Xue and Kai Zhu and Bing Yan}, doi = {10.1002/anie.202425436}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202425436}, shortjournal = {Angew. Chem. Int. Edit.}, title = {σ-π hyperconjugation as a design strategy for high-performance fluorescent covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Breaking the limitation of laminar flow in thrombolytic therapy with reconfigurable vortex-like nanobot swarms. ANGEW, 64(17), e202425189. (www)

  @article{ , abstract = {Laminar blood flow represents the normal physiological state of blood circulation, but it also acts as a natural physiological barrier for the effective diffusion of drugs to the lesion site. Here, we report a bioinspired strategy in which reconfigurable vortex-like swarms of magnetic swimming nanobots actively disrupt the laminar flow to deliver drugs in a manner similar to how bacteria seek food. The drug was released from the cavity of biodegradable, submicron pentosan flask-like nanobots, aggregates as the dynamic rotating drug fluid under a rotating magnetic field. The vortex-like nanobot swarm successfully overcame the laminar barrier near the thrombus in a rat inferior vena cava stenosis thrombosis model, which was observed by ultrasound blood flow imaging. Furthermore, the clinical feasibility of nanobots swarm for enhancing thrombolytic efficacy through drug aggregation after breaking the laminar flow was further confirmed in a rat deep vein thrombosis model. This bionic active targeting approach overcomes the laminar flow barrier and restricts the release of drugs by the swarm-induced vortex fluid to facilitate targeted drug delivery, which is expected to be an innovative method to enhance drug delivery efficiency.}, archive = {J_ANGEW}, author = {Tingxin Yang and Tieyan Si and Yingjie Wu and Jinhong Liu and Luru Dai and Xiankun Lin and Mingjun Xuan and Xiaoping Leng and Qiang He}, doi = {10.1002/anie.202425189}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202425189}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking the limitation of laminar flow in thrombolytic therapy with reconfigurable vortex-like nanobot swarms}, volume = {64}, year = {2025}, }
• (2025). Facilitating OH* generation on atomic Pd–Cu dual sites towards efficient glycerol electrooxidation to formate. ANGEW, 64(17), e202425006. (www)

  @article{ , abstract = {The electrocatalytic glycerol oxidation reaction (GOR) represents a mild and sustainable pathway to produce value-added chemicals such as formate. However, the rational design and controlled synthesis of efficient catalysts to achieve highly selective C−C bond cleavage of glycerol towards formate remains a great challenge. Herein, atomic Pd doped Cu 3 N hollow nanocubes with Pd−Cu dual sites were prepared via the unique Kirkendall process, exhibiting superior electrocatalytic GOR activity and selectivity towards formate with a maximum Faraday efficiency of 91.6 %. In situ spectroscopic characterization and theoretical calculations reveal that Pd atoms located in partial Cu substituent sites could facilitate the generation of active *OH and enhance the adsorption of glycerol molecule on adjacent Cu sites, while Pd atoms located in Cu 3 N unit center could effectively reduce the energy barrier of C−C bond cleavage for the rate determining step. Our work provides new insights into the development of well-defined dual-site catalysts to boost glycerol electrooxidation to formate.}, archive = {J_ANGEW}, author = {Junjun Li and Yizhen Zhang and Liya Zhang and Qi Zhou and Jiangrong Yang and Yu Fu and Le Yu and Yuanmiao Sun and Zhenhua Li and Yuchen Qin and Ding Yi and Hui Zhang and Dingsheng Wang and Zhicheng Zhang}, doi = {10.1002/anie.202425006}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202425006}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facilitating OH* generation on atomic Pd–Cu dual sites towards efficient glycerol electrooxidation to formate}, volume = {64}, year = {2025}, }
• (2025). High-performance white circularly polarized photoluminescence and electroluminescence from multi-emission enantiomers. ANGEW, 64(17), e202424918. (www)

  @article{ , abstract = {A pair of multi-emission enantiomers, ( R )- DO-PSeZ and ( S )- DO-PSeZ , was designed and synthesized by integrating Se-induced conformationally isomeric donors with a chiral carbonyl-containing acceptor into a unified molecular framework. The enantiomers showed white emission with blue, yellow and red multi-emission bands in solution and film at CIE coordinates of (0.39, 0.35) and (0.33, 0.34), respectively. Doped film of the enantiomers achieved a high photoluminescence quantum yield of 42 %, accompanied by mirror-image white circularly polarized photoluminescence (WCPPL) signals with a | g PL | value of 2.6×10 −3 . Moreover, the enantiomers also showed white circularly polarized electroluminescence (WCPEL) in organic light-emitting diodes with CIE coordinates of (0.29, 0.33) and EQE max of 3.1 %. Notably, this work represents the first single-molecule multi-emission WCPL materials and achieved the highest performance for white OLEDs based on single-molecule organic materials with phosphorescent properties. Furthermore, leveraging Bragg reflection from dual-layer cholesteric liquid crystals, the enantiomers achieved | g PL | and | g EL | values of 1.85 and 1.88, respectively, marking the highest reported values for WCPPL and WCPEL to date.}, archive = {J_ANGEW}, author = {Pei Zhao and Wei-Chen Guo and Hai-Yan Lu and Chuan-Feng Chen}, doi = {10.1002/anie.202424918}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424918}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance white circularly polarized photoluminescence and electroluminescence from multi-emission enantiomers}, volume = {64}, year = {2025}, }
• (2025). Direct asymmetric α-alkylation of β-ketocarbonyl compounds with simple olefins by photoredox-nickel-hydrogen atom transfer triple catalysis. ANGEW, 64(17), e202424915. (www)

  @article{ , abstract = {Although the asymmetric α-alkylation of carbonyl compounds with activated olefins has already been established, extending this methodology to less activated or nonactivated olefins remains a significant challenge due to the polarity mismatch in these ionic processes. An alternative approach involves the activation of the parent carbonyl compounds into electrophilic α-carbonyl radicals, which could potentially overcome this limitation. However, the lack of efficient catalytic systems has impeded the wide adoption of this strategy, particularly in realm of the catalytic asymmetric reactions. Here, we present a cooperative triple catalytic system that integrates photoredox, chiral Lewis acid, and hydrogen atom transfer (HAT) catalysts to achieve a direct asymmetric α-alkylation of β-ketocarbonyl compounds using simple olefins as alkylating agents. By combining a multifunctional chiral nickel Lewis acid with an iridium photoredox catalyst and a thiophenol catalyst under visible light, we have developed a highly efficient process that is temporally synchronized to facilitate a novel mechanism of electron and hydrogen transfer. This triple catalytic approach enables the intermolecular coupling of β-ketocarbonyl compounds with both less and non-activated olefins. This redox-neutral protocol provides an atom- and step-economic route to enantioselectively synthesize high-value molecules featuring an all-carbon quaternary stereocenter from feedstock chemicals, while only consuming photons.}, archive = {J_ANGEW}, author = {Xue-Song Zhou and Zi-Qing Li and Wen-Yuan Qu and Zhihan Zhang and Wen-Jing Xiao and Jia-Rong Chen}, doi = {10.1002/anie.202424915}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424915}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct asymmetric α-alkylation of β-ketocarbonyl compounds with simple olefins by photoredox-nickel-hydrogen atom transfer triple catalysis}, volume = {64}, year = {2025}, }
• (2025). Structural regulation of three-dimensional covalent organic frameworks for efficient photoredox catalysis toward atom transfer radical polymerization. ANGEW, 64(17), e202424860. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have emerged as a thriving class of photocatalysts in various chemical transformations. However, the utilization of COFs as photoredox catalysts for atom transfer radical polymerization is rarely known. Herein, we designed and synthesized a series of phenazine-based functional 3D COFs with the dia topology. Structural regulation over interpenetration folds and energy levels of COFs was implemented through the substituent effects. These COFs can work as effective photoredox catalysts toward atom transfer radical polymerization. Notably, DADP-CF 3 -COF with trifluoromethyl group exhibits much higher catalytic activity than other COFs, allowing the efficient synthesis of polymers with controllable molecular weights, low dispersity, and high conversion. This work not merely realizes the structural regulation of 3D COFs through substituent effects, but also exhibits brilliant prospects for the utilization of COFs as efficient catalysts in a bunch of challenging chemical transformations.}, archive = {J_ANGEW}, author = {Sheng Niu and Zhenyang Hu and Xiaoyi Xu and Zuping Xiong and Hongzheng Chen and Alex K.-Y. Jen and Ning Huang}, doi = {10.1002/anie.202424860}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424860}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural regulation of three-dimensional covalent organic frameworks for efficient photoredox catalysis toward atom transfer radical polymerization}, volume = {64}, year = {2025}, }
• (2025). N-heterocyclic carbene vs. thiophene – Chiral adsorption and unidirectional rotation on au(111). ANGEW, 64(17), e202424715. (www)

  @article{ , abstract = {N -Heterocyclic carbenes are highly effective ligands for anchoring functional organic molecules to metal surfaces and nanoparticles, facilitating the formation of self-assembled monolayers. However, their adsorption on surface is difficult to predict and control, and there is an ongoing debate on the geometry of NHC derivatives on gold surfaces and on the role of gold adatoms. We present two single molecules based on a benzimidazole NHC, one equipped with a thiophene substituent, and the other ending with a Br atom. By low temperature scanning tunneling microscopy we show that both molecules adsorb planar on Au(111) and are chiral on the surface. Our results indicate that in both cases a complex between NHC and a gold adatom is formed. Upon voltage pulses with the STM tip, both complexes move excited by inelastic tunneling electrons. For the derivative with thiophene, we observe a stepwise 60° unidirectional rotation around the S atom. The direction of rotation is determined by both the chirality and the position of the applied pulse. On the contrary, the NHC derivative without thiophene moves laterally on the surface. Adsorption, binding to gold atoms, and motion are discussed with the support of density functional theory calculations and image simulations.}, archive = {J_ANGEW}, author = {Natasha Khera and Ningwei Sun and Soyoung Park and Pranjit Das and Kwan Ho Au-Yeung and Suchetana Sarkar and Franz Plate and Roberto Robles and Nicolas Lorente and Franziska S.-C. Lissel and Francesca Moresco}, doi = {10.1002/anie.202424715}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424715}, shortjournal = {Angew. Chem. Int. Edit.}, title = {N-heterocyclic carbene vs. thiophene – Chiral adsorption and unidirectional rotation on au(111)}, volume = {64}, year = {2025}, }
• (2025). Au(I)-, Au(II)-, Au(III)-fluoride complexes: Synthesis and applications in organic transformations. ANGEW, 64(17), e202424656. (www)

  @article{ , abstract = {The synthesis and reactivity of organometallic gold-fluoride complexes in oxidation states of Au (I) , Au (II) , and Au (III) , up to and including 2024, are reviewed herein. Despite the flourishing field of gold catalysis, these complexes had long been elusive due to their instability. A widespread interest in C−C and C−F coupling reactions has resulted in several reports of these complexes in recent years. The use of a variety of supporting ligands have facilitated access to these complexes, which has allowed their reactivity to be further studied and understood, thereby laying the ground for future reaction development. This review highlights these advances, organised by the formal oxidation state of the gold centre and the supporting ligand.}, archive = {J_ANGEW}, author = {Alexi T. Sedikides and Rhian C. Walters and Alice C. Dean and Alastair J. J. Lennox}, doi = {10.1002/anie.202424656}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424656}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Au(I)-, Au(II)-, Au(III)-fluoride complexes: Synthesis and applications in organic transformations}, volume = {64}, year = {2025}, }
• (2025). Electrochemical redox synergism-enhanced liquid metal locomotion for unrestricted circuit substrate patterning. ANGEW, 64(17), e202424637. (www)

  @article{ , abstract = {The critical challenge in advancing liquid metal circuits (LMCs) lies in achieving interfacial compatibility with diverse substrates while dynamically balancing fabrication efficiency and quality to ensure robust conductive stability. Here we introduce an electrochemical redox synergistic liquid metal (E- rs LM) that enables the controllable generation of diverse intermetallic bond transition layers (Cu, Au, or Fe-based) between liquid metal and unrestricted substrate surfaces, applicable in pH-universal electrolytes. It involves enhanced locomotion of the liquid metal, driven by synergistic electrochemical energy transduction from cyclic changes in gallium redox states. Characterized by expansion-contraction-expansion, it enables unique self-propelled bouncing, tuning spreading speed (up to ~26.8 mm/s) and elongation rate (up to 1192 %) with a volume of only 80 μL. Additionally, we demonstrate the adaptability of E- rs LM fabrication across 30 different substrates, highlighting its versatility. The patterning displays the superimposed efficiency and self-indicated quality, leading to superior conductivity (with time-cost savings of 30.7 % and 13.4 % in heating-cooling cycles, and a nearly 90 % reduction in output resistance). The practical viability of these circuits is further showcased by the assembly of integrated circuits, marking a significant step in expanding LMCs applications beyond laboratory-scale prototypes.}, archive = {J_ANGEW}, author = {Yi Fan and Yigang Shen and Wenli Zhang and Guochao Zeng and Tete Liu and Yilan Wang and Shuli Wang and Jing Zheng and Xu Hou}, doi = {10.1002/anie.202424637}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical redox synergism-enhanced liquid metal locomotion for unrestricted circuit substrate patterning}, volume = {64}, year = {2025}, }
• (2025). Capturing the progressive conformational evolutions of sterically-congested dihydrophenazines via crystallization. ANGEW, 64(17), e202424597. (www)

  @article{ , abstract = {To gain a deeper understanding of the sequential multistep excited-state structural evolutions of N , N ′-diphenyl-dihydrodibenzo[ a , c ]phenazine ( DPAC ) luminophores, we strategically freeze distinct conformations by crystallization, allowing to capture the progressive conformational transformations within a DPAC -based framework by utilizing single-crystal X-ray diffractometry. Our focus lies in the innovative modification of DPAC via the synthesis of cyano (CN)-substituted derivatives DPAC- n CN ( n =1–4, with n indicating the number of CN groups). The incorporation of electron-withdrawing CN groups modulates electron delocalization and lowers energy barriers, facilitating access to conformational polymorphism within the crystals. Unlike the limited diversity observed in the crystallization behaviour of DPAC , the DPAC-2CN to DPAC-4CN derivatives exhibit distinct crystalline forms, with conformational diversity increasing in tandem with the number of CN substituents. Notably, the single DPAC-4CN molecule features multi-colored crystals transitioning from blue to red, with the folding angle of the polycyclic dihydrodibenzo[ a , c ]phenazine ring progressive varying from ~130° to ~172°. Additionally, DPAC-4CN ’s red crystals with high-energy planar conformation (~172°) can experience a sudden jumping when subjected to stimuli. This study not only advances the understanding of conformational dynamics in dihydrophenazines but also paves a new way for the development of dynamic crystal materials.}, archive = {J_ANGEW}, author = {Ziyu Chen and Xin Jin and Ruizi Shen and Wen Li and Lu Sun and Jianhua Su and Da-Hui Qu and Zhiyun Zhang and He Tian}, doi = {10.1002/anie.202424597}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424597}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Capturing the progressive conformational evolutions of sterically-congested dihydrophenazines via crystallization}, volume = {64}, year = {2025}, }
• (2025). Residual monomer-induced side reactions in gel polymer electrolytes: Unveiled high-ni cathode failure in lithium batteries. ANGEW, 64(17), e202424568. (www)

  @article{ , abstract = {Coupling gel polymer electrolytes (GPEs) with high-Ni cathodes (NCM) has emerged as a compelling approach for high-energy lithium-ion batteries, capable of circumventing NCM failure modes in liquid electrolytes. However, a detailed origin of capacity decay caused by residual monomers from an uncontrollable curing process has been largely ignored. Here, we report an in-depth investigation into the side reactions of unreacted monomers within typical GPEs at the NCM cathode interfaces by utilizing multiscale spectroscopy combined with theoretical calculations. We evaluate conversion rate-interphase structure correlation, revealing that interfacial evolution is highly dependent on residual monomer content. Specifically, the degradation chemistry in NCM cathodes with thermally cured gel polymer electrolytes (TC-GPEs) is governed by monomer-initiated interphase reconstruction, leading to an imbalanced interphase growth mode with organic-rich species and retarded diffusion kinetics through the electrode. We further reveal that organic ether/ester-based byproducts, caused by the oxidative decomposition of unreacted monomers during the initial charging step, are the key factor in the acceleration of NCM failure modes. This study elucidates the multiscale fading mechanism in the NCM||GPE system, providing improved insights into interphase issues in typical GPEs and facilitating the further development of long-life NCM||GPE prototypes for commercial applications.}, archive = {J_ANGEW}, author = {Min Su Choi and Sang Goo Kang and Jaehoon Choi and Jeonghyun Ko and Jong Hyeok Park}, doi = {10.1002/anie.202424568}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424568}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Residual monomer-induced side reactions in gel polymer electrolytes: Unveiled high-ni cathode failure in lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Revisiting photocatalytic CO2 reduction to methanol: A perspective focusing on metal-organic frameworks. ANGEW, 64(17), e202424537. (www)

  @article{ , abstract = {Photocatalytic CO 2 reduction to CH 3 OH, particularly with metal-organic frameworks (MOFs) as photocatalysts, has garnered significant attention due to its long-term potential to harness sunlight for converting CO 2 into a valuable fuel and chemical feedstock. Numerous studies in the literature report the successful formation of CH 3 OH from photocatalytic CO 2 reduction, sometimes supplemented with sacrificial agents, with claims substantiated by isotopic labelling measurements. However, in this Scientific Perspective, we note that much of the existing evidence has not been obtained under sufficiently rigorous experimental conditions to conclusively confirm the formation of a highly reactive product like CH 3 OH from the chemically stable CO 2 molecule. This Scientific Perspective outlines best practices designed to provide robust evidence for CH 3 OH formation in photocatalytic processes, which could be instrumental in clarifying the state-of-the-art and accelerating the development of this technology toward practical applications.}, archive = {J_ANGEW}, author = {Vitor Fernandes de Almeida and Sergio Navalón and Amarajothi Dhakshinamoorthy and Hermenegildo Garcia}, doi = {10.1002/anie.202424537}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424537}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revisiting photocatalytic CO2 reduction to methanol: A perspective focusing on metal-organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Machine learning-driven mass discovery and high-throughput screening of fluoroether-based electrolytes for high-stability lithium metal batteries. ANGEW, 64(17), e202424493. (www)

  @article{ , abstract = {Developing novel fluoroether electrolytes with high-voltage stability is an effective strategy to improve the performance of lithium metal batteries (LMB). However, the vast chemical space of fluoroether is underexplored due to the absence of effective tools to evaluate the potential used in high-voltage LMB. Herein, a framework was developed in combination of Voting ensemble algorithms and graph convolution neural network (GCNN), allowing the fast assessment of oxidative stability of non-aqueous liquid electrolytes, synthesizability of solvents as well as the solvation ability of them to dissolve lithium salts. Potential fluoroether solvent candidates for high-voltage LMB were screened out from a virtual library comprising 5576 electrolytes constructed by a combination of 1510 solvents and 4 salts. Among them, two fluorinated ethers, 1,1,1,3,3,3-hexafluoro-2-(2-methoxyethoxy) propane and 7,7,8,8-tetrafluoro-3,12-dimethoxy-2,5,10,13-tetraoxatetradecane, were successfully synthesized and showed satisfactory high-voltage stability, sufficient solvation ability and satisfactory cycling with almost 99.5 % coulombic efficiency in Li||NMC811 full cell. This work provided an efficient framework for the discovery of solvents with high-voltage tolerance in a vast structural space prior to experimental synthesis, accelerating the development of advanced electrolyte for high-energy-density rechargeable batteries.}, archive = {J_ANGEW}, author = {Qingqing Jia and Hongguang Liu and Xueping Wang and Qiantu Tao and Lifeng Zheng and Junjie Li and Wei Wang and Ziteng Liu and Xu Gu and Tianyu Shen and Shaoyi Hou and Zhong Jin and Jing Ma}, doi = {10.1002/anie.202424493}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning-driven mass discovery and high-throughput screening of fluoroether-based electrolytes for high-stability lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Modulated π-bridge of thioxothiazolidine derivatives for passivating bilateral interfaces and grain boundaries in n-i-p perovskite solar cells. ANGEW, 64(17), e202424472. (www)

  @article{ , abstract = {Additive engineering has emerged as the predominant approach for enhancing the performance of perovskite solar cells (PSCs). Donor-π-acceptor (D-π-A) dyes with tailored configurations have proven to be a viable and effective strategy for passivating defects and optimizing interfacial contacts. In this study, we present two asymmetrical D-π-A dyes, designated as TZR and TNR. These dyes are designed and synthesized with identical hole- and electron-transporting backbones but feature distinct π-bridge groups. They are incorporated into the precursor solution of PbI 2 to facilitate in situ passivation of both interfaces and grain boundaries (GBs) during the formation of the perovskite film (two-step process). These dyes effectively penetrate both buried and upper interfaces, allowing for the passivation of defects originating from the GBs, and both interfaces. This significantly reduces defects while enhancing charge transport properties. Notably, the π-bridge composed of benzo[1,2,5]-thiadiazole in TZR contains unpaired electrons from nitrogen and sulfur atoms. An impressive power conversion efficiency (PCE) of 25.11 % is achieved. This performance significantly surpasses that of TNR-based and pristine devices, achieving PCEs of 24.47 % and 22.88 %, respectively. Furthermore, we observed a significant improvement in the stability of the unencapsulated device, attributed to the exceptional hydrophobicity of the D-π-A dyes. This study offers valuable insights into achieving high-performance PSCs through careful molecular design.}, archive = {J_ANGEW}, author = {Zhichao Lin and Yibing Wu and Xinhua Ouyang}, doi = {10.1002/anie.202424472}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulated π-bridge of thioxothiazolidine derivatives for passivating bilateral interfaces and grain boundaries in n-i-p perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Selective hydrodisulfuration of alkenes with dithiosulfonate. ANGEW, 64(17), e202424209. (www)

  @article{ , abstract = {In this study, we have discovered the versatility of the dithiosulfonate reagent (ArSO 2 -SSR) in transition metal catalyzed selective hydrodisulfuration of unactivated alkenes. The hydrodisulfuration displays a unique Markovnikov selectivity with a Salen-cobalt complex, while an anti -Markovnikov selectivity is observed when employing a nickel/bidentate N -donor ligand. Furthermore, precise control over nickel/ligand enables the successful achievement of remote site-selective hydrodisulfuration for both internal and terminal alkenes via a chain-walking process. In these processes, silanes are employed as a hydride source. Mechanistic insights into these innovative catalytic systems are also elucidated. Experimental findings suggest that Markovnikov hydrodisulfuration is likely to proceed through radical substitution on dithiosulfonate reagents, while nickel catalyzed anti -Markovnikov selectivity and remote site-selectivity likely occur via the radical addition of the reductively formed dithiosulfonate radical anion ([ArSO 2 -SSR]⋅ − ) to alkyl Ni (II) species (alkyl-Ni (II) L n X) and subsequent reductive elimination on Ni (III) intermediate (alkyl–Ni (III) L n (X)-SSR) as the key steps based on DFT calculation analysis.}, archive = {J_ANGEW}, author = {Wenhao Li and Haonan Wei and Baoxu Wang and Xihang He and Yao Jiang and Mengna Nie and Hang Yan and Zijing Hu and Qianwen Gao and Shuanglin Qu and Xi Wang}, doi = {10.1002/anie.202424209}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424209}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective hydrodisulfuration of alkenes with dithiosulfonate}, volume = {64}, year = {2025}, }
• (2025). Ortho-carborane-derived halogen bonding organocatalysts. ANGEW, 64(17), e202424072. (www)

  @article{ , abstract = {Multidentate neutral halogen bonding catalysts based on iodinated icosahedral ortho -carborane moieties are introduced. Co-crystallization-studies, calorimetric measurements, and 1 H NMR titrations demonstrate their strong binding to halides and neutral compounds, further underlined by quantum-chemical calculations. Thus, their superior Lewis acidity compared to traditional perfluorinated halogen-bond donors has been shown. The iodocarborane catalysts also outperformed the latter in a halide abstraction reaction and catalyzed a nitro-Michael addition reaction, which was previously out of reach for neutral halogen-bonding-based organocatalysts.}, archive = {J_ANGEW}, author = {Christoph J. Vonnemann and Elric Engelage and Jas S. Ward and Kari Rissanen and Sandro Keller and Stefan M. Huber}, doi = {10.1002/anie.202424072}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424072}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ortho-carborane-derived halogen bonding organocatalysts}, volume = {64}, year = {2025}, }
• (2025). A wide band gap germanate with the largest second harmonic generation response created by hypoxic strategy. ANGEW, 64(17), e202424053. (www)

  @article{ , abstract = {Nonlinear optical material is one of the core components for modern laser equipment. The second harmonic generation (SHG) intensity and optical band gap are two key indicators of such materials. Herein, a wide band gap germanate, Li 3 (OH)PbGeO 4 , with the largest SHG intensity has been created successfully by hypoxic strategy via traditional hydrothermal reactions. The cations in this structure all coordinate with oxygen anions at their lowest coordination number, forming polar PbO 3 triangular pyramid and noncentrosymmetric GeO 4 , LiO 4 tetrahedrons. Li 3 (OH)PbGeO 4 exhibits a remarkable SHG response of about 27×KH 2 PO 4 (KDP), 54 % higher than the previous record. The band gap of Li 3 (OH)PbGeO 4 can reach to 3.74 eV, exceeding most inorganic germanates with SHG intensity larger than 3×KDP. Structural analysis and PAWED calculations indicate that its strong SHG response is due to the synergistic effects from PbO 3 , GeO 4 and LiO 4 groups. Furthermore, Li 3 (OH)PbGeO 4 can also present compelling broadband white-light emission with a high color-rendering index of up to 93. Our work not only breaks the record of SHG intensity in germanates but also provides an effective strategy in exploring new inorganic optical functional crystals.}, archive = {J_ANGEW}, author = {Qi-Chang Song and Chun-Li Hu and Fang Kong and Jiang-Gao Mao}, doi = {10.1002/anie.202424053}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202424053}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A wide band gap germanate with the largest second harmonic generation response created by hypoxic strategy}, volume = {64}, year = {2025}, }
• (2025). Gold self-assembly on copper electrodes promotes n-propanol formation in electrochemical CO2 reduction. ANGEW, 64(17), e202423882. (www)

  @article{ , abstract = {The electrochemical CO 2 reduction reaction (CO 2 RR) offers a promising route to mitigate greenhouse gas emissions by converting CO 2 into valuable chemicals. Among multi-carbon products, n-propanol is particularly appealing due to its high energy density (~27 MJ/L) and broad industrial applications. However, achieving high selectivity for n-propanol remains a formidable challenge, requiring catalysts capable of facilitating complex reaction pathways and avoiding competing side reactions. In this study, we present a Cu/Cys/Au catalyst architecture that is prepared through a self-assembled monolayer (SAM) that significantly enhances the Faradaic efficiency for n-propanol production. Specifically, Cu substrates are modified with cysteamine SAMs to uniformly anchor a Au 3+ -dimercaptosuccinate complex, which enable uniform Au electrodeposition. The resulting Cu/Cys/Au electrode achieves a Faradaic efficiency of 29.1 % for n-propanol at −1.2 V vs. RHE, representing a significant improvement over conventional Au−Cu electrocatalysts. Control studies reveal the necessity of both Au and Cu for selective n-propanol formation, while mixed SAMs with varying cysteamine and propanethiol ratios allow for precise tuning of Au coverage on Cu. These findings underscore the potential of SAM-based strategies for precise surface engineering, offering a pathway for selective CO 2 RR electrocatalysts.}, archive = {J_ANGEW}, author = {Nikhil C. Bhoumik and Quinn A. Padovan and Tania Akter and David K. Stem and Christopher J. Barile}, doi = {10.1002/anie.202423882}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423882}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gold self-assembly on copper electrodes promotes n-propanol formation in electrochemical CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Higher contrast in 1H-observed NMR ligand screening with the PEARLScreen experiment. ANGEW, 64(17), e202423879. (www)

  @article{ , abstract = {For initial hit identification in fragment-based drug design, NMR is one of the preferred methods, with the well-established ligand screening experiments T 1ρ , waterLOGSY and STD. Here, we present a new, perfect echo-based experiment with superior binding sensitivity, the PEARLScreen. The sensitivity enhancement is based on longer relaxation delays as well as active exchange broadening, enabled by the perfect echo scheme. This allowed a reduction of the protein concentration by up to one order of magnitude in comparison to the conventional experiments on the same screening setup without losing binding sensitivity. The experiment was tested throughout the whole field range of commercially available spectrometers from 80 to 1200 MHz, where at the highest field even a reduction of the required protein amount by a factor of 40 is within reach, thanks to larger compound mixtures and enhanced exchange effects. Based on the superior performance already on standard NMR setups, we expect the PEARLScreen to become the standard screening experiment for 1 H-detected ligand screening.}, archive = {J_ANGEW}, author = {Nils Lorz and Barbara Czarniecki and Sandra Loss and Benno Meier and Alvar D. Gossert}, doi = {10.1002/anie.202423879}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423879}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Higher contrast in 1H-observed NMR ligand screening with the PEARLScreen experiment}, volume = {64}, year = {2025}, }
• (2025). Desymmetrization/Kinetic resolution of planar chiral [2.2]Paracyclophanes by bioinspired peptide-iminophosphorane catalysis. ANGEW, 64(17), e202423702. (www)

  @article{ , abstract = {Planar chiral [2.2]paracyclophanes, particularly pseudo-disubstituted derivatives, are privileged scaffolds for chiral ligands and catalysts in asymmetric synthesis and have widespread applications in materials science. However, catalytic asymmetric approaches for the enantioselective synthesis of pseudo-disubstituted [2.2]paracyclophanes remain underexplored. In this study, we introduce a novel class of peptide-iminophosphorane organosuperbases to induce planar chirality in spatially stacked [2.2]paracyclophanes. This efficient protocol enables the enantioselective synthesis of a diverse array of structurally distinct pseudo-gem, pseudo-ortho, and pseudo-para [2.2]paracyclophanes, achieving high yields and excellent enantioselectivities via desymmetrization or kinetic resolution. Moreover, the products can be readily diversified through various functional group transformations. Mechanistic investigations provide valuable insights into the unique stereocontrol exhibited by this peptide-iminophosphorane catalytic system.}, archive = {J_ANGEW}, author = {Zhengdong Wu and Siqiang Fang and Jiajia He and Jixing Che and Zanjiao Liu and Xin Wei and Zhishan Su and Tianli Wang}, doi = {10.1002/anie.202423702}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Desymmetrization/Kinetic resolution of planar chiral [2.2]Paracyclophanes by bioinspired peptide-iminophosphorane catalysis}, volume = {64}, year = {2025}, }
• (2025). Zinc(II)-enhanced excimer probe for recognition of MDMB-CA synthetic cannabinoids. ANGEW, 64(17), e202423576. (www)

  @article{ , abstract = {Specific recognition with optical responses towards the analytes which are structurally diverse and weak chemical-active remains a big challenge but is of great significance. Here, a zinc(II) enhanced fluorescent emission probe was developed by conjugated modulating and metal bridging to specifically recognize synthetic cannabinoids (SCs). The transformed luminescence mechanism from excimer emission to fluorescence resonance energy transfer was demonstrated upon the integration of coordination and non-covalent interactions towards target SCs. As a result, the specific and instant detection of the certain type SCs (MDMB-CA series) was achieved in complicated sample medium. Hence, we envisage that this work would not only offer a novel recognition strategy for SCs, but also advance the development of the optical sensing probe especially for analyzing the substances with diverse structures and weak chemical-activity, as well as for fighting against the illicit drugs.}, archive = {J_ANGEW}, author = {Yihang Wang and Jiahao Dong and Yuan Liu and Longlong Liang and Yuwan Du and Xincun Dou}, doi = {10.1002/anie.202423576}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423576}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zinc(II)-enhanced excimer probe for recognition of MDMB-CA synthetic cannabinoids}, volume = {64}, year = {2025}, }
• (2025). Bimodal ionic conduction through polymer films due to nano confinement. ANGEW, 64(17), e202423548. (www)

  @article{ , abstract = {Kinetic and selectivity of ionic conduction through polymer films is a key factor in the function of many systems including membrane technology, energy devices, sensors, and corrosion. Typically, the ionic conduction is accelerated by increasing the ionic strength of the electrolyte. However, counterintuitively, polymer films with very high electrochemical impedance demonstrate the opposite effect, i. e. ionic conduction slows down by increasing the ionic strength of the electrolyte. This bimodal nature of ionic conduction was discovered five decades ago and yet the mechanism has remained poorly understood. This minireview explains the long-standing anomaly through the lens of recent advances in nano-confinement electrochemistry. Emerging evidence shows that changes in solvation shells occurs due to the size of the channel through which ionic diffusion takes place. These solvation shells can significantly affect the mobility of ions, their interactions with functional groups of the polymer, and the overall conductivity of the electrolyte. At dimensions only a few nanometers, partially hydrated ions form stronger bonds with polymer slowing down the ionic conduction. Increasing ionic strength will add ion-pairing interactions further reducing ions mobility. The interplay of solvated ions, polymer chemistry, and ionic content offer an explanation for the anomalous bimodal ionic conduction.}, archive = {J_ANGEW}, author = {Sina S. Jamali and Navid Kashaninejad and Yulin Zhong and Nam-Trung Nguyen}, doi = {10.1002/anie.202423548}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423548}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bimodal ionic conduction through polymer films due to nano confinement}, volume = {64}, year = {2025}, }
• (2025). A versatile carbonylative approach to ureas and carbamates through light activated nickel catalyzed formation of aliphatic isocyanates. ANGEW, 64(17), e202423519. (www)

  @article{ , abstract = {We describe the development of a nickel-catalyzed route to prepare aliphatic isocyanates via carbonylation chemistry. Unlike thermal reactions, where the affinity of Ni(0) for carbon monoxide has traditionally limited its use in carbonylations, mechanistic studies suggest that visible light excitation of a Xantphos-bound nickel catalyst can enable a radical pathway for the carbonylation of alkyl halides, while the CO-bound nickel drives the formation of a reactive acyl azide product for rapid Curtius rearrangement. Coupling this transformation with subsequent nucleophilic reactions has opened a unique and modular pathway to apply carbonylations to the synthesis of an array of diversely substituted, unsymmetrical ureas and carbamates, including those of relevance to drug design.}, archive = {J_ANGEW}, author = {Cuihan Zhou and Dushyant Singh and Bruce A. Arndtsen}, doi = {10.1002/anie.202423519}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423519}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A versatile carbonylative approach to ureas and carbamates through light activated nickel catalyzed formation of aliphatic isocyanates}, volume = {64}, year = {2025}, }
• (2025). Full-scale regulation enabled high-performance sodium o3-type layered cathodes. ANGEW, 64(17), e202423479. (www)

  @article{ , abstract = {O3-type cathodes hold considerable promise in achieving rapid commercialization due to high energy density. However, severe structural/interfacial deterioration, along with kinetic hindrance, typically resulting in rapid capacity fading and serious safety risk at elevated cut-off voltages. Herein, inspired from solubility limitation of hetero-elements, synchronous surface-to-bulk multifunctionally full-scale modified O3-NaNi 1/3 Fe 1/3 Mn 1/3 O 2 is proposed to maintain its state of health (SOH). The perovskite-type CaZrO 3 protective layer in situ formed on the surface of primary particles, helps to construct a stable cathode-electrolyte-interphase architecture, mitigate the unexpected interfacial side reactions and prevent transition metal dissolution. Simultaneously, Ca 2+ pillars, robust Zr−O bonds and the highly electronegative F − are adequately anchored into ternary lattice sites of Na-TM−O, respectively, thereby reinforcing the TMO 6 octahedra and facilitating Na + diffusion. Notably, the intrinsic lattice strain is effectively alleviated due to an additional intergrowth phase transition of P3-OP2. More impressively, migration of Jahn-Teller distorted Fe 4+ O 6 is further restrained, originating from the strengthened coordination environment under deep-desodiation state. Consequently, as-designed NFM-CZF achieves an impressive rate capability and a remarkable capacity retention of 83.8 % after 300 cycles at 2 C. This elaborate work shed valuable insight into mechanism of regulating internal full Wyckoff-site and external surface structure for sodium-ion batteries with enhanced durability.}, archive = {J_ANGEW}, author = {Ningyun Hong and Shuncheng Zhang and Jianwei Li and Haoji Wang and Jiangnan Huang and Xinyu Hu and Baichao Zhang and Fang Hua and Jingyao Zeng and Weishun Jian and Chao Sun and Nesrin Bugday and Wentao Deng and Guoqiang Zou and Hongshuai Hou and Zhanggui Hu and Zhen Long and Yicheng Wu and Xiaobo Ji}, doi = {10.1002/anie.202423479}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423479}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Full-scale regulation enabled high-performance sodium o3-type layered cathodes}, volume = {64}, year = {2025}, }
• (2025). An artificial copper-michaelase featuring a genetically encoded bipyridine ligand for asymmetric additions to nitroalkenes. ANGEW, 64(17), e202423182. (www)

  @article{ , abstract = {Artificial metalloenzymes (ArMs) are an attractive approach to achieving “new to nature” biocatalytic transformations. In this work, a novel copper-dependent artificial Michaelase (Cu_Michaelase) comprising a genetically encoded copper-binding ligand, i. e. (2,2-bipyridin-5-yl)alanine (BpyA), was developed. For the first time, such an ArM containing a non-canonical metal-binding amino acid was successfully optimized through directed evolution. The evolved Cu_Michaelase was applied in the copper-catalyzed asymmetric addition of 2-acetyl azaarenes to nitroalkenes, yielding various γ-nitro butyric acid derivatives, which are precursors for a range of high-value-added pharmaceutically relevant compounds, with good yields and high enantioselectivities (up to >99 % yield and 99 % ee). Additionally, the evolved variant could be further used in a preparative-scale synthesis, providing chiral products for diverse derivatizations. X-ray crystal structure analysis confirmed the binding of Cu(II) ions to the BpyA residues and showed that, in principle, there is sufficient space for the 2-acetyl azaarene substrate to coordinate. Kinetic studies showed that the increased catalytic efficiency of the evolved enzyme is due to improvements in apparent K M for both substrates and a notable threefold increase in apparent k cat for 2-acetyl pyridine. This work illustrates the potential of artificial metalloenzymes exploiting non-canonical metal-binding ligands for new-to-nature biocatalysis.}, archive = {J_ANGEW}, author = {Ru Jiang and Fabrizio Casilli and Andy-Mark W. H. Thunnissen and Gerard Roelfes}, doi = {10.1002/anie.202423182}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423182}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An artificial copper-michaelase featuring a genetically encoded bipyridine ligand for asymmetric additions to nitroalkenes}, volume = {64}, year = {2025}, }
• (2025). Identifying the key photosensitizing factors over Metal–Organic frameworks for selective control of 1O2 and o2⋅− generation. ANGEW, 64(17), e202423157. (www)

  @article{ , abstract = {The reaction pathway, product selectivity and catalytic efficiency of photo-oxidation are highly dependent on the specific reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and superoxide (O 2 ⋅ − ), generated via the sensitization of O 2 by photosensitizers. Studies on uncovering the role of photosensitizing factors on the selective control of 1 O 2 and O 2 ⋅ − generation are significant but remain underexplored. Here, we constructed a photosensitizing metal–organic framework molecular platform (UiO-1–UiO-4) by elaborately engineering Ir(III) complex ligands with pyrenyl group for modulating photosensitizing factors and elucidating their impact on ROS generation. Impressively, the ratios of 1 O 2 and O 2 ⋅ − generation varied from 0 : 100 for UiO-1 to 94 : 6 for UiO-4 by modulating photosensitizing factors. UiO-2 and UiO-4 were respectively immobilized in a continuous-flow reactor, achieving gram-scale photosynthesis of phenol and juglone with high purity (>94 %) via O 2 ⋅ − and 1 O 2 pathway, respectively. Investigations reveal that UiO-4 with ligand localized excited state and long excited state lifetime contributed to triggering energy transfer to afford 1 O 2 , whereas UiO-1 with charge-transfer state and negative reduction potential facilitates charge transfer to produce O 2 ⋅ − . This work offers a novel insight into regulating ROS generation by modulating the photosensitizing factors at the molecular level.}, archive = {J_ANGEW}, author = {Xiao-Liang Ma and Li-Hua Ma and Song Guo and Zhi-Ming Zhang and Tong-Bu Lu}, doi = {10.1002/anie.202423157}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423157}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identifying the key photosensitizing factors over Metal–Organic frameworks for selective control of 1O2 and o2⋅− generation}, volume = {64}, year = {2025}, }
• (2025). Structural and mechanistic insight into the enantioselectivity of (R)-selective styrene monooxygenases: A tug-of-war between proximal and distal residues. ANGEW, 64(17), e202423117. (www)

  @article{ , abstract = {Group E flavoprotein monooxygenases (GEMs) are well-known for catalyzing enantioselective epoxidation reactions. However, engineering their enantioselectivity remains a significant challenge, largely due to a limited understanding of the underlying mechanisms. Among these enzymes, ( R )-selective styrene monooxygenases (( R )-SMOs) stand out due to their unusual enantio-switch behavior when catalyzing the reactions of p -substituted styrenes. This unique property provides an exceptional opportunity to investigate the enantiocontrol mechanisms within GEMs. In this study, we resolved the first crystal structure of an ( R )-SMO, Se StyA, derived from Streptomyces . By integrating this structural information with molecular docking and molecular dynamics (MD) simulations, we identified four key residues critical to enantiodivergency: two distal residues (S178 and A219) and two proximal residues (A59 and A312). Strikingly, a “tug-of-war” mechanism was revealed through saturation mutagenesis, wherein the side-chain sizes of proximal and distal residues exerted opposing influences on enantioselectivity at the C=C bond. Leveraging this mechanistic insight, we successfully engineered SMOs with excellent ( R )- or ( S )-enantioselectivity.}, archive = {J_ANGEW}, author = {Zhi-Pu Li and Lanteng Wang and Yan Liu and Xiao-Qiong Pei and M. Qaiser Fatmi and Zhuanglin Shen and Jian Zhao and Hui Lin and Jiahai Zhou and Zhong-Liu Wu}, doi = {10.1002/anie.202423117}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202423117}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural and mechanistic insight into the enantioselectivity of (R)-selective styrene monooxygenases: A tug-of-war between proximal and distal residues}, volume = {64}, year = {2025}, }
• (2025). Boosting C-O bond cleavage and reverse water-gas shift activity via enriched in-plane sulfur vacancies in single-layer molybdenum disulfide. ANGEW, 64(17), e202422953. (www)

  @article{ , abstract = {The reduction of CO 2 to CO provides a promising approach to the production of valuable chemicals through CO 2 utilization. However, challenges persist with the rapid deactivation and insufficient activity of catalysts. Herein, we developed a soft-hard dual-template method to synthesize layered MoS 2 using inexpensive and scalable templates, enabling facile regulation of sulfur vacancies by controlling the number of layers. The concentration of in-plane vacancies keeps increasing with the reduction of MoS 2 layer number, contributing to 100 % CO selectivity over single-layer MoS 2 and a stable performance over 300-hour reaction at 600 °C. The space-time-yield of CO reached 35.7 g CO g cat −1 h −1 , outperforming most current catalysts. Multiple characterizations and theoretical calculations revealed that in-plane sulfur vacancy sites endowed enhanced production of CO via direct dissociation of CO 2 , showing an intrinsic activity of above 5.8 times higher than that of edge sulfur vacancy sites. The rate-limiting step was shifted from C−O cleavage in edge to sulfur vacancy regeneration in plane with a lower energy barrier. Our findings exemplified the specified design and synthesis of MoS 2 for high-temperature CO 2 reduction through the effective manipulation of distinct vacancy sites, shedding light on their potential industrial application.}, archive = {J_ANGEW}, author = {Zhiyuan Zheng and Xin Shang and Weijue Wang and Xiaofeng Yang and Xiong Su and Yanqiang Huang}, doi = {10.1002/anie.202422953}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202422953}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting C-O bond cleavage and reverse water-gas shift activity via enriched in-plane sulfur vacancies in single-layer molybdenum disulfide}, volume = {64}, year = {2025}, }
• (2025). Exceptional CO2 hydrogenation to ethanol via precise single-atom ir deposition on functional p islands. ANGEW, 64(17), e202422744. (www)

  @article{ , abstract = {The thermocatalytic hydrogenation of CO 2 to ethanol has attracted significant interest because ethanol offers ease of transport and substantial value in chemical synthesis. Here, we present a state-of-the-art catalyst for the CO 2 hydrogenation to ethanol achieved by precisely depositing single-atom Ir species on P cluster islands situated on the In 2 O 3 nanosheets. The Ir 1 -P x /In 2 O 3 catalyst achieves an impressive ethanol yield of 3.33 mmol g −1 h −1 and a turnover frequency (TOF) of 914 h −1 under 1.0 MPa (H 2 /CO 2 =3 : 1) at 180 °C, nearly 8 times higher than that of the unmodified Ir 1 /In 2 O 3 catalyst. Additionally, at a more industrially relevant pressure of 5.0 MPa, the TOF of the Ir 1 -P x /In 2 O 3 catalyst can reach up to 2108 h −1 , surpassing previously reported catalysts. Combined in situ characterization and theoretical studies reveal that the hydrogenation process is significantly enhanced by the Ir 1 -P x entities. Specifically, the Ir atom facilitates CO 2 activation and C−C coupling, while the surrounding P island exhibits exceptional H 2 dissociation ability. These three steps have been found crucial for the CO 2 hydrogenation reaction. This discovery opens new opportunities for the regulation of the microenvironment of current catalysts by providing essential chemical functionalities that enhance intricate and complex reaction processes.}, archive = {J_ANGEW}, author = {Lingyue Liu and Jinjie Liu and Guangchao Li and Xiuwen Shi and Jun Yin and Shourong Zheng and Ka-Fu Yung and Hong Bin Yang and Tsz Woon Benedict Lo}, doi = {10.1002/anie.202422744}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202422744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exceptional CO2 hydrogenation to ethanol via precise single-atom ir deposition on functional p islands}, volume = {64}, year = {2025}, }
• (2025). Expanding the molecular switches toolbox: Photoreloadable dithienylethene mechanophores. ANGEW, 64(17), e202422549. (www)

  @article{ , abstract = {Molecular switches are often thought of as nanoscopic equivalents to the electrical buttons and knobs ubiquitous in everyday life. However, mechanical force is rarely used to reversibly trigger rearrangements at the atomic scale, due to the difficulty in selectively breaking certain bonds, while keeping others intact. Here, we introduce two new mechanophores based on dithienylethene (DTE), which can be toggled between two states by ultraviolet light and sonication. Attaching various lengths of poly(ϵ-caprolactone) either to the 2,2′ or the 5,5′ positions of the DTE core allowed us to study the kinetics of its mechanochemical cycloreversion. We employed computational methods to understand the root causes of the observed mechano-regiochemical differences. Lastly, we show that our best performing DTE-polymer conjugate can undergo numerous switching cycles by the alternating action of electromagnetic radiation and mechanical force.}, archive = {J_ANGEW}, author = {Medeina Steponavičiūtė and Debashis Majee and Bisheng Zhao and Liviu Ungur and Stanislav Presolski}, doi = {10.1002/anie.202422549}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202422549}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expanding the molecular switches toolbox: Photoreloadable dithienylethene mechanophores}, volume = {64}, year = {2025}, }
• (2025). Noble gas provides a solution to the synthesis-on-inert-surfaces challenge for extended covalent nanostructures. ANGEW, 64(17), e202422521. (www)

  @article{ , abstract = {A key milestone in the field of On-Surface Synthesis (OSS) is the development of generic protocols for covalent coupling on inert surfaces. Typically, metal surfaces are used in OSS, but the strong interactions distort the intrinsic properties of the synthesized nanostructures and therefore compromise their applicability. Inert surfaces, on the other hand, preserve the nanostructures’ unique properties, but present challenges during synthesis: Activation energies are generally higher than on metal surfaces, hence thermally activated coupling on inert surfaces is severely hampered by competing premature desorption of the reactants. Using the coupling of 1,3,5-tris(4-mercaptophenyl)benzene (TMB) via carbon-sulfur-carbon thioether bonds, we demonstrate that annealing in a noble gas atmosphere instead of in a vacuum kinetically inhibits desorption. This allows covalent coupling on both inert graphite and even more weakly interacting graphene surfaces. We anticipate generic potential for this approach, with future experiments exploring the expandability of ambient pressure annealing to a portfolio of other coupling protocols.}, archive = {J_ANGEW}, author = {Lukas Grossmann and Sascha Korn and Rochus Breuer and Michael Schmittel and Heiko B. Weber and Wolfgang M. Heckl and Markus Lackinger}, doi = {10.1002/anie.202422521}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202422521}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Noble gas provides a solution to the synthesis-on-inert-surfaces challenge for extended covalent nanostructures}, volume = {64}, year = {2025}, }
• (2025). Lactate-modulating nanozyme-mediated mitochondrial respiration block for tumor immunosuppression remodeling. ANGEW, 64(17), e202422203. (www)

  @article{ , abstract = {Abnormal lactate metabolism in tumor cells leads to immune escape in the tumor microenvironment. Intervening in specific lactate metabolic pathways while blocking downstream pyruvate influx holds great promise for overcoming conventional lactate-targeted therapy limitations such as short half-life, insufficient lactate consumption, and pathological microenvironment elasticity. Herein, a nanocatalytic medicine based on carbondoping engineered copper nitride enzyme (Cu 3 N−C NE) with enhanced lactate oxidase (LOX) activity was carefully designed. Computational results revealed that the introduction of C favors activation of the hydroxyalkyl C−H bond in lactate by the polarization of adjacent hydroxyl groups, correspondingly facilitating the abstraction of hydrogen atoms from the desired α-C−H and α-C−O−H groups in lactate via the hydrogen atom-transfer (HAT) process. The Cu 3 N−C NEs could downregulate lactate levels in tumor cells for robust remodeling of the immunosuppressive microenvironment and further block as-generated pyruvate to influx into the mitochondrial respiration, achieving lactate homeostasis reprogramming. Our study provides a proof-of-concept design of next-generation lactate-modulation nanomedicine via heteroatom-doping and evolution with the additional potential to expedite the industrial production of lactate to pyruvate.}, archive = {J_ANGEW}, author = {Senfeng Zhao and Jianing Hou and Liu Deng and Ziyu Qi and Na Tao and Wenjie Ruan and Jia Zheng and Wei Wang and Qianqian Xu and Qimanguli Saiding and Na Kong and You-Nian Liu and Wei Tao}, doi = {10.1002/anie.202422203}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202422203}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lactate-modulating nanozyme-mediated mitochondrial respiration block for tumor immunosuppression remodeling}, volume = {64}, year = {2025}, }
• (2025). Molecular origin of the stretchability and fatigue-resistance of rotaxane-based mechanically interlocked polymer networks. ANGEW, 64(17), e202422104. (www)

  @article{ , abstract = {Rotaxane-based polymer networks leveraging host–guest recognition have recently emerged as a versatile platform for developing smart materials. Despite numerous studies on these polymers, their unique mechanical properties are mostly associated with the sliding motion of the macrocycle along the axle, leaving the impact of the presence or absence of interlocked structures on the mechanical performance of materials yet to be directly demonstrated. In this work, we present a densely (pseudo)rotaxane-based supramolecular polymeric network (SPN) and a mechanically interlocked network (MIN) as model systems to explore how the mechanical interlocking unit dominates the material properties. Specifically, we have achieved a significant transition from SPN to MIN by finely tuning the stopper size, just substituting a methyl with a dimethyl group attached to the phenyl ring. Although their stereochemical structures are similar, a subtle increase in the stopper size can lead to striking improvements in stretchability and anti-fatigue performance. The stopper size-relevant dethreading behavior, as evidenced by a combined approach of solid-state NMR spectroscopy and rheology, is the underlying molecular mechanism for the difference in the macroscopic mechanical properties. We anticipate that the fundamental understanding gained from this work will advance the development of rotaxane-based materials with emergent functions and applications.}, archive = {J_ANGEW}, author = {Lin Cheng and Wenbin Wang and Ruixue Bai and Wei You and Yuling Liang and Zhiwei Yan and Rongchun Zhang and Xuzhou Yan and Wei Yu}, doi = {10.1002/anie.202422104}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202422104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular origin of the stretchability and fatigue-resistance of rotaxane-based mechanically interlocked polymer networks}, volume = {64}, year = {2025}, }
• (2025). Highly entangled hydrogels by photoiniferter-mediated polymerization. ANGEW, 64(17), e202421970. (www)

  @article{ , abstract = {We report the synthesis of ultra-high molecular weight (UHMW) poly( N,N -dimethylacrylamide) (PDMAm) hydrogels with extremely low crosslinking densities by trithiocarbonate photoiniferter-mediated reversible deactivation radical polymerization (RDRP). Fixing the photoiniferter to crosslinker ratio and gradually increasing the targeted degree of polymerization ( DP target ) allowed for simultaneous control over the crosslinking density and the average molecular weight ( M n ) of the primary chains, both below and above the critical molecular weight of entanglement ( M c ). Interestingly, a plateau in storage moduli ( G’ ) was observed for UHMW PDMAm hydrogels with a sufficiently high DP target (>5,000), indicating a transition to the entanglement-dominated regime, with no contribution from crosslinks to the overall modulus, thus indicating the formation of highly entangled hydrogels. These hydrogels exhibit enhanced properties such as high toughness and resistance to swelling despite their vanishingly small crosslinking densities. Furthermore, even when equipped with cleavable crosslinkers, the UHMW PDMAm hydrogels resist degradation due to dense entanglements which act as transient crosslinks preventing the gels from swelling, while sparse covalent crosslinks help to maintain their structural integrity and avoid chain disentanglement. This approach allows simple synthesis of elastic and tough hydrogels with a well-defined structure and tuneable contributions from both crosslinks and entanglements.}, archive = {J_ANGEW}, author = {Gavin Irvine and Konstantinos Myronidis and Fulvio Pinto and Maciej Kopeć}, doi = {10.1002/anie.202421970}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202421970}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly entangled hydrogels by photoiniferter-mediated polymerization}, volume = {64}, year = {2025}, }
• (2025). High-performance zinc halogen aqueous battery exploiting [BrCl2]− storage in ketjenblack by reconstructing electrolyte structure. ANGEW, 64(17), e202421905. (www)

  @article{ , abstract = {Halogen redox couples offer distinct merits due to high redox potential and low cost, but they usually suffer from poor reversibility. Here, we report highly reversible [Br 2 Cl] − /Br − and [BrCl 2 ] − /Cl − redox couples via harnessing interhalogen chemistry within nanoporous Ketjenblack (KB) carbon as a host for zinc-based aqueous batteries. The tunable halogen reactions are facilitated by controllable coordinating chemistry of [ZnCl 4- x Br x ] 2− in a hydrated deep eutectic solvent electrolyte comprising ZnCl 2 , ZnBr 2 , and choline chloride (C 5 H 14 ClNO). In an optimized electrolyte, the KB electrode delivers a high discharge capacity of 535 mAh g KB −1 or 214 mAh g −1 when the stored [BrCl 2 ] − is counted at 100 mA g −1 , with an average discharge voltage of ~1.6 V, and a record high energy density of 788 Wh kg KB −1 or 315 Wh kg −1 , when considering the mass of [BrCl 2 ] − as well. Benefiting from the interhalogen coordination chemistry and KB pore host, the pouch cell delivers an areal capacity of 2.3 mAh cm −2 at 0.5 mA cm −2 , storing an energy density of ~80 Wh kg −1 based on the mass of both electrodes. This work offers a new strategy to enhance the reversibility of static aqueous halogen batteries for energy storage applications.}, archive = {J_ANGEW}, author = {Jiajin Zhao and Yadi Qi and Yan Chen and Mengyan Zhang and Ziqi An and Wenfeng Wang and Binbin Nian and Yuan Li and Shumin Han and Lu Zhang}, doi = {10.1002/anie.202421905}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202421905}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance zinc halogen aqueous battery exploiting [BrCl2]− storage in ketjenblack by reconstructing electrolyte structure}, volume = {64}, year = {2025}, }
• (2025). Aqueous Zr/HfIV-oxo cluster speciation and separation. ANGEW, 64(17), e202421819. (www)

  @article{ , abstract = {Many industrial separations of chemically-similar elements are achieved by solvent extraction, exploiting differences in speciation and solubility across aqueous-organic interfaces. We recently identified [OM 4 (OH) 6 (SCN) 12 ] 4− (OM 4 , M=Zr/Hf IV ) tetrahedral oxoclusters as the main species in industrial processes that produce nuclear-grade Zr and Hf from crude ore. However, isostructural/isoelectronic OM 4 -oxoclusters do not explain selective extraction of Hf into the organic phase. Here we have characterized heterometal Hf−Zr clusters in solution and the solid-state yielding key information about their fundamentally different chemistry that engenders separation. Clusters prepared with both ammonium (industrial process) and tetramethylammonium counter cations revealed that 1) heterometal clusters (instead of a mixture of homometal clusters) assemble, and 2) Hf-rich OM 4 selectively precipitates over Zr-rich OM 4 , providing a separation process that does not require an organic extractant. Mass spectrometry, small-angle X-ray scattering, solution-state 1 H nuclear magnetic resonance (NMR) spectroscopy, and solid-state 17 O NMR evidence both mixed-metal speciation and selective Hf-precipitation. Raman spectroscopy suggests greater Zr-ligand lability than Hf-ligand lability, consistent with higher aqueous solubility of Zr-rich clusters, enabling both extraction and precipitation-based separation. Fundamentally, we also identify a key difference between these chemically similar elements that has enabled diversification of Zr-polyoxocation chemistry over the last decade, while Hf-polyoxocation chemistry lags.}, archive = {J_ANGEW}, author = {Alexander Roseborough and Ryan Loughran and Lev N. Zakharov and Christopher A. Colla and May Nyman}, doi = {10.1002/anie.202421819}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202421819}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aqueous Zr/HfIV-oxo cluster speciation and separation}, volume = {64}, year = {2025}, }
• (2025). Quantum chemical understanding of the o2 release process from nature's water splitting cofactor. ANGEW, 64(17), e202421383. (www)

  @article{ , abstract = {Natural photosynthesis plays a vital role in the supply of energy and oxygen necessary for the survival of biological organisms. The current leading proposal of the O−O bond formation in photosystem II suggests the coupling between the central μ-oxo (O5) and the additional oxygenic ligand (Ox) of the manganese-calcium oxide cofactor. However, the subsequent process through which molecular dioxygen is formed and released remains elusive. In this report, quantum chemical calculations reveal that the O 2 release process is initiated by the cleavage of the Mn−O5 bond, without a preliminary conformational change of the peroxide [O5-Ox] 2− group. Subsequently, the [O5-Ox] moiety is converted from the superoxide to the weakly bound quasi-O 2 where the Mn−Ox bond is cleaved, and after a twist of the quasi-O 2 unit, the free O 2 is ultimately released. Alternative pathways display significantly slower kinetics, due to the lower structural stabilities of the rate-limiting transition states. The cause of the difference is associated with the Jahn-Teller axial orientation and the local ring strain within the Mn cluster. These findings contribute to unravelling the intricate mechanism involved in an important step of photosynthetic oxygen evolution for a deeper understanding of nature's water oxidation catalysis.}, archive = {J_ANGEW}, author = {Yu Guo and Lars Kloo and Licheng Sun}, doi = {10.1002/anie.202421383}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202421383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantum chemical understanding of the o2 release process from nature's water splitting cofactor}, volume = {64}, year = {2025}, }
• (2025). Self-accelerated controllable phase transformation for practical liquid metal electrode. ANGEW, 64(17), e202421020. (www)

  @article{ , abstract = {Despite the high theoretical capacity, the deposition of solid alkali metals can trigger dendrites growth, causing safety risk, capacity and life decay. While liquid NaK alloy is dendrite-free, their fluidity may cause leakage or even short circuit. In this work, a novel controllable phase transformation strategy was proposed enabled NaK anode to be processed in near-solid and work in liquid, effectively overcoming the challenges of dendrite formation and leakage. Specifically, a near-solid anode was fabricated by liquid metal (LM)-assisted mechanochemistry reaction, which can be easily shaped and integrated into batteries without leakage risk. Then self-accelerated phase transformation continues within the battery, driven by an LM-mediated in situ replacement reaction, converts the near-solid electrode into liquid state and enabling dendrite-free operation. For the first time, a cylindrical cell with liquid NaK alloy anode was successfully matched and demonstrated excellent electrochemical performances. This innovation not only enhances safety but also advancing the practical application of liquid metal electrodes in energy storage systems.}, archive = {J_ANGEW}, author = {Chichu Qin and Li Huang and Xuan Zhong and Zhiyong Xia and Guanwu Li and Guanqing Cheng and Lu Huang and Yingpeng Wu}, doi = {10.1002/anie.202421020}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202421020}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-accelerated controllable phase transformation for practical liquid metal electrode}, volume = {64}, year = {2025}, }
• (2025). Engineering surface tension of active layer solutions to form uniform films on water surface for large-area flexible organic photovoltaic modules. ANGEW, 64(17), e202420226. (www)

  @article{ , abstract = {Fabricating large-area uniform thin (about 100 nm) active layer films via solution processing is still challenging to realize efficient scalable organic photovoltaic (OPV) modules. In this work, we report a method to fabricate large-area active layer films with the help of Marangoni force via engineering the surface tension of their solutions. Silicone oil was first adopted as an additive to substantially reduce surface tension of the active layer solutions from 34.8 to 20.6 mN/m. Large-area (up to 700 cm 2 ) thin active layer films formed spontaneously on water by Marangoni force due to the increased surface tension difference between the active layer solution and water. The films were then transferred onto charge transporting layer to fabricate devices. The active layer films fabricated by Marangoni force-assisted coating (MAC) displayed power conversion efficiencies (PCE), 17.4 ±0.3 % for PM6:BTP-eC9, 17.9±0.7 % for D18:N3 and 16.4±0.3 % for PM6:QM-1. Furthermore, large-area (32.5 cm 2 ) OPV modules were fabricated based on the MAC method with a PCE of 14.3 %. This is the first example that MAC method is used to successfully fabricate efficient OPV modules via the surface tension engineering of active layer films with silicone oil used as a low surface tension additive.}, archive = {J_ANGEW}, author = {Kai Feng and Xianmin Zhou and Yerun Gao and Jianping Chen and Junfeng Liu and Xinlu Liu and Qi Luo and Qijin Zhou and Zedong Xiong and Xiaoru Wang and Ming Shao and Hongwei Han and Yinhua Zhou}, doi = {10.1002/anie.202420226}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202420226}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering surface tension of active layer solutions to form uniform films on water surface for large-area flexible organic photovoltaic modules}, volume = {64}, year = {2025}, }
• (2025). Two-dimensional perovskites for photocatalytic CO2 reduction. ANGEW, 64(17), e202418708. (www)

  @article{ , abstract = {The photocatalytic conversion of Carbon dioxide (CO 2 ) into valuable chemicals is one of the most promising approaches to addressing the CO 2 emission problem. However, several issues still need to be resolved to increase the efficiency of photocatalytic reactions. Perovskites possess superior light absorption capacity, tunable band gaps, high defect tolerance, and diverse dimensionality. Among them, two-dimensional (2D) perovskites are more stable under photocatalytic conditions and have exciting excitonic characteristics compared to three-dimensional (3D) perovskites. 2D perovskites have unique physical and chemical properties, such as high stability, polaron formation, quantum well structures, and high exciton binding energies, which remain underexplored for photocatalytic CO 2 reduction (pCO 2 RR). Tuning these properties is easier in 2D perovskites than in 3D perovskites by varying the layer thickness and spacer cations. Therefore, 2D perovskite photocatalysts are emerging as promising materials for reducing CO 2 into valuable products. This review discusses the classification and synthesis methods of 2D perovskites, the unique properties that make them favorable for photocatalysis, and recent advances in applying 2D perovskites for pCO 2 RR by monitoring the operational methodology. It also emphasizes the potential for future developments in photocatalysis using 2D perovskites.}, archive = {J_ANGEW}, author = {Jagmeet Kaur and Sebastian C. Peter}, doi = {10.1002/anie.202418708}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202418708}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-dimensional perovskites for photocatalytic CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Solvent-dependent chirality transmission and amplification from cellulose derivative to achiral helical polymer for achieving full-color and white circularly polarized luminescence. ANGEW, 64(17), e202418463. (www)

  @article{ , abstract = {Cellulose derivatives represent a promising natural chiral platform for creating circularly polarized luminescence (CPL) materials owing to their excellent processability and structural diversity. However, achieving full-color and white CPL emissions based on cellulose derivatives remains challenging. The present work reports the first success in achieving full-color and white CPL emissions leveraging chirality transmission and amplification from cellulose derivative to achiral helical polymer. Importantly, such chirality transfer displays a dependence on the hydrogen bond accepting ability of solvent, making it effortless to precisely regulate chiral intensity by single or combined solvents. Moreover, the induced chirality in helical polymer is further transferred to the introduced racemic fluorescent dyes, resulting in full-color and white-light CPL emissions with a maximum luminescence dissymmetry factor ( g lum ) and photoluminescence quantum yield (PLQY) up to 1.5×10 −2 and 62.9 %, respectively. Further spatially separating the chiral and fluorescent components allows inversion of CPL handedness and precise modulation of CPL intensity. Notably, circularly polarized white organic light-emitting diodes and chiral logic gate with multiple information outputs are successfully developed. This work gives an impetus to construct cellulosic chiroptical materials, offering more insights into chirality transfer between biomacromolecules and synthetic helical polymers.}, archive = {J_ANGEW}, author = {Hai Zhong and Biao Zhao and Jianping Deng}, doi = {10.1002/anie.202418463}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202418463}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-dependent chirality transmission and amplification from cellulose derivative to achiral helical polymer for achieving full-color and white circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Catalyst improved stereoselectivity and regioselectivity control to access completely alternating poly(lactic-co-glycolic acid) with enhanced properties. ANGEW, 64(17), e202417075. (www)

  @article{ , abstract = {The poly(lactic-co-glycolic acid) (PLGA) with completely alternating sequence has attracted growing attention as an ideal candidate in controlled drug delivery. However, the approach to completely alternating PLGA remains a challenge. Herein, we report the successful synthesis of completely alternating PLGA via highly regioselective and stereoselective ring-opening polymerization. The chiral (BisSalen)Al catalyst promoted a robust polymerization of enantiopure 3-methyl glycolide (MeG) with highly glycolyl site selectivity, affording alternating PLGA with regioselectivity up to more than 99 %. Impressively, the completely alternating PLGA exhibited a well-defined melting temperature T m of 143.1 °C. Moreover, a stereocomplex between PLLGA and PDLGA was also formed with the improved T m of 211.8 °C. The In vitro degradation and drug release experiments revealed the linear degradation and controlled drug release behavior of completely alternating PLGA, which can be used as an ideal carrier for mild long-acting drug delivery. Meanwhile, the reason of the high regioselectivity was investigated through the control experiments and DFT calculation. This highly regioselective (BisSalen)Al catalyst opens a door to providing completely alternating polymers.}, archive = {J_ANGEW}, author = {Xuanhua Guo and Hassan Ahmed and Guangqiang Xu and Qinggang Wang}, doi = {10.1002/anie.202417075}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202417075}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalyst improved stereoselectivity and regioselectivity control to access completely alternating poly(lactic-co-glycolic acid) with enhanced properties}, volume = {64}, year = {2025}, }
• (2025). A green and efficient recycling strategy for spent lithium-ion batteries in neutral solution environment. ANGEW, 64(17), e202414899. (www)

  @article{ , abstract = {Traditional acid or/and ammonia leaching techniques are usually applied to extract valuable metals during hydrometallurgical recovery of spent lithium-ion batteries. However, the excessive and repeated use of acids and bases inevitably increases the environmental burden and safety threats. Herein, considering the advantages of neutral pH solution system in terms of safety and environmental protection, neutral leaching has been pioneeringly proposed to achieve a low-cost and harmless hydrometallurgical process. Specifically, benefited from the ligand complexation reaction of glycine, the valuable metals can be efficiently leached within neutral environment. More importantly, a strategy of solid-solid reduction with primary batteries effect is employed to achieve an efficient neutral leaching within rapid time, breaking through the reaction limitation of shrinking core model. As anticipated, an efficient leaching of 99.99 % Li, 96.86 % Ni, 92.35 % Co, and 90.59 % Mn can be achieved within 15 minutes, which has extended applications for various kinds of layered cathodes. Therefore, it is sturdily confirmed that the intractable problem, the effective extraction is available only under the aggressive acid/alkali-ion conditions, is well-solved within a mild leaching atmosphere. This green and efficient strategy in neutral solution environment opens a new pathway to realize the large-scale pollution-free recycling of spent batteries.}, archive = {J_ANGEW}, author = {Zhilong Xu and Long Ye and Yun Yu and Haiqiang Gong and Zhiming Xiao and Lei Ming and Bao Zhang and Zhen Yao and Jiexi Wang and Xing Ou}, doi = {10.1002/anie.202414899}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202414899}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A green and efficient recycling strategy for spent lithium-ion batteries in neutral solution environment}, volume = {64}, year = {2025}, }
• (2025). Target agnostic photoaffinity labelling by sulfonylhydrazones. ANGEW, 64(17), e202408701. (www)

  @article{ , abstract = {Photoaffinity labeling is a widely used methodology for interrogating small molecule-protein interactions. However, these applications are limited by the few photo-crosslinkers that typically modify the affinity and the binding mode of the original ligand. Here, we report the development of new target agnostic photoaffinity warheads, sulfohydrazones that form a reactive carbene upon UV irradiation. Careful optimization of the reaction conditions allowed us to effectively label five different amino acid residues in proteins. Our approach turned biologically relevant hydrazones and sulfohydrazones to intrinsically irreversible covalent binders without structural modifications by photoactivation as demonstrated on monoamine oxidase A (MAO-A) enzyme and STAT5b (Signal transducer and activator of transcription 5b) transcription factor. Sulfohydrazones are readily accessible by transforming the corresponding carbonyl group of a ligand or a suitable tag that extends the application domain of the method for any ligands exemplified by conditional labelling of the acetylcholine esterase enzyme and the oncogenic mutant of GTP-ase KRas G12D .}, archive = {J_ANGEW}, author = {Kristóf Garami and Nikolett Péczka and László Petri and Tímea Imre and Tamás Langó and Zoltán Szabó and Zoltán Orgován and Pál Szabó and György Miklós Keserü and Péter Ábrányi-Balogh}, doi = {10.1002/anie.202408701}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {17}, pages = {e202408701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Target agnostic photoaffinity labelling by sulfonylhydrazones}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Multicomponent reaction integrating Selenium(II)–Nitrogen exchange (SeNEx) chemistry and copper-catalyzed Azide–Alkyne cycloaddition (CuAAC). ANGEW, 64(16), e202581662. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202581662}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202581662}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Multicomponent reaction integrating Selenium(II)–Nitrogen exchange (SeNEx) chemistry and copper-catalyzed Azide–Alkyne cycloaddition (CuAAC)}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: The interplay between component denticity and flexibility promotes the formation of [AgI⋅⋅⋅AgI]-stabilised links and knots. ANGEW, 64(16), e202581661. (www)

  @article{ , archive = {J_ANGEW}, author = {Aleksandra Sarwa and Andrei Khmara and Krzysztof A. Konieczny and Dagmara Kulesza and Eugeniusz Zych and Bartosz Trzaskowski and Bartosz Szyszko}, doi = {10.1002/anie.202581661}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202581661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: The interplay between component denticity and flexibility promotes the formation of [AgI⋅⋅⋅AgI]-stabilised links and knots}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Helically chiral mixed-valence systems comprising n heterotriangulenes: Stabilization of the cationic species by π expansion (Angew. chem. int. ed. 16/2025). ANGEW, 64(16), e202506101. (www)

  @article{ , archive = {J_ANGEW}, author = {Jan Borstelmann and Simon Zank and Marcel Krug and Georg Berger and Nina Fröhlich and Gabriel Glotz and Frederik Gnannt and Lars Schneider and Frank Rominger and Felix Deschler and Timothy Clark and Georg Gescheidt and Dirk M. Guldi and Milan Kivala}, doi = {10.1002/anie.202506101}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202506101}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Helically chiral mixed-valence systems comprising n heterotriangulenes: Stabilization of the cationic species by π expansion (Angew. chem. int. ed. 16/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Giant bulk photovoltaic effect in a chiral polar crystal based on helical one-dimensional lead halide perovskites (Angew. chem. int. ed. 16/2025). ANGEW, 64(16), e202506098. (www)

  @article{ , archive = {J_ANGEW}, author = {Ayumi Ishii and Ryohei Sone and Tomohide Yamada and Mizuki Noto and Hikari Suzuki and Daiki Nakamura and Kei Murata and Takuya Shiga and Kazuyuki Ishii and Masayuki Nihei}, doi = {10.1002/anie.202506098}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202506098}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Giant bulk photovoltaic effect in a chiral polar crystal based on helical one-dimensional lead halide perovskites (Angew. chem. int. ed. 16/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Single-step synthesis of dimethyl ether from syngas over nanoparticle-derived bifunctional Pd/CeO2/Al2O3 catalysts (Angew. chem. int. ed. 16/2025). ANGEW, 64(16), e202505854. (www)

  @article{ , archive = {J_ANGEW}, author = {Bing Wang and Zairan Yu and Shuang Chen and Nicola Da Roit and Dieter Schild and Michael Zimmermann and Yuemin Wang and Silke Behrens}, doi = {10.1002/anie.202505854}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202505854}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Single-step synthesis of dimethyl ether from syngas over nanoparticle-derived bifunctional Pd/CeO2/Al2O3 catalysts (Angew. chem. int. ed. 16/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Photo-patternable and healable polymer semiconductor enabled by dynamic covalent disulfide bonding (Angew. chem. int. ed. 16/2025). ANGEW, 64(16), e202505567. (www)

  @article{ , archive = {J_ANGEW}, author = {Xiang Xue and Cheng Li and Xiaobo Yu and Kaiyuan Chenchai and Xinyue Zhang and Xisha Zhang and Guanxin Zhang and Deqing Zhang}, doi = {10.1002/anie.202505567}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202505567}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Photo-patternable and healable polymer semiconductor enabled by dynamic covalent disulfide bonding (Angew. chem. int. ed. 16/2025)}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: Correction to “Green syngas production from natural lignin, sunlight, and water over pt-decorated InGaN nanowires”. ANGEW, 64(16), e202504104. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202504104}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202504104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: Correction to “Green syngas production from natural lignin, sunlight, and water over pt-decorated InGaN nanowires”}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: RETRACTION: Brønsted acid Catalysis—Controlling the competition between monomeric versus dimeric reaction pathways enhances stereoselectivities. ANGEW, 64(16), e202503912. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202503912}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202503912}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: RETRACTION: Brønsted acid Catalysis—Controlling the competition between monomeric versus dimeric reaction pathways enhances stereoselectivities}, volume = {64}, year = {2025}, }
• (2025). Angewandte chemie novit – Elevating top-tier chemistry research. ANGEW, 64(16), e202503680. (www)

  @article{ , archive = {J_ANGEW}, author = {Charlotte Gers-Panther and Frank Maaß and Nathalie Weickgenannt}, doi = {10.1002/anie.202503680}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202503680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Angewandte chemie novit – Elevating top-tier chemistry research}, volume = {64}, year = {2025}, }
• (2025). Photobiocatalytic reaction: From single component to triple components. ANGEW, 64(16), e202502489. (www)

  @article{ , abstract = {Despite remarkable advances in photoenzymatic methodologies, the development of photoenzymatic multicomponent reactions remains a significant challenge. In this Highlight, we showcase a recent breakthrough by Prof. Xiaoqiang Huang and co-workers, who achieved enantioselective triple-component radical sorting via visible light-induced biocatalysis under mild conditions. This innovative approach opens new avenues for the synthesis of complex molecules with high precision and efficiency, marking a remarkable advance in the field of enzymatic photocatalysis.}, archive = {J_ANGEW}, author = {Rui-Tao Sun and Peng Chen and Sheng-Zhen Xu and Liang-Qiu Lu and Wen-Jing Xiao}, doi = {10.1002/anie.202502489}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202502489}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photobiocatalytic reaction: From single component to triple components}, volume = {64}, year = {2025}, }
• (2025). H-bonds in carbon quantum dot-anchored C3N5 to boost proton-coupled electron transfer for piezoelectric-driven hydrogen peroxide synthesis under ambient conditions. ANGEW, 64(16), e202502390. (www)

  @article{ , abstract = {Tuning proton-coupled electron transfer (PCET) is a promising strategy to boost the oxygen reduction reaction (ORR) for hydrogen peroxide (H 2 O 2 ) synthesis, but the slow transmission rate of protons and electrons to active sites remains a significant bottleneck. To address this, we developed an H-bond-driven PCET process based on carbon quantum dot-anchored C 3 N 5 (CQDs-C 3 N 5 ) for piezo-catalytic H 2 O 2 synthesis. CQDs-C 3 N 5 exhibited a remarkable piezo-catalytic synthesis rate of 5025 μmol g −1 h −1 under ambient conditions, surpassing that of most reported piezoelectric materials. This efficiency is attributed to the intermolecular H-bonds between CQDs and C 3 N 5 , which significantly accelerate PCET in the ORR. The piezoelectric-generated charges, from the dipole field of the C 3 N 5 plane, and protons in water, were rapidly transferred to the C rings of CQDs via H-bond networks. This process facilitated the adsorption of oxygen onto the C2 sites adjacent to the carboxyl groups of CQDs, which in turn led to the formation of H 2 O 2 through a rapidly protonated, indirect 2e − pathway. Additionally, a piezo-self-Fenton reaction system was constructed for oxytetracycline-rich wastewater purification, with effectively effects on chemical oxygen demand, antibiotic-resistant bacteria and antibiotic-resistant genes degradation, etc . This study highlights the critical role of H-bond networks for tuning PCET in the ORR and provides a comprehensive understanding for the precise control of catalytic reaction kinetics through molecular structural engineering.}, archive = {J_ANGEW}, author = {Zhi Li and Kangbo Tong and Haojie Dong and Yatai Li and Kai Wang and Tengda Ding and Yang Yun and Yingtang Zhou and Mingshan Zhu}, doi = {10.1002/anie.202502390}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202502390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {H-bonds in carbon quantum dot-anchored C3N5 to boost proton-coupled electron transfer for piezoelectric-driven hydrogen peroxide synthesis under ambient conditions}, volume = {64}, year = {2025}, }
• (2025). Mass activity elucidation of cobalt-based oxygen evolution catalysts utilizing depth-resolved spectroscopy in the presence of various cations with chloride. ANGEW, 64(16), e202501579. (www)

  @article{ , abstract = {The oxygen evolution reaction (OER) in water electrolysis is a kinetically sluggish reaction that requires catalysts with high electrocatalytic activity. Cobalt oxide (CoO x ) is among the best performing OER catalysts and has been reported to have “bulk activity” with active sites distributed within the material. Herein, we examined the distribution of OER activity over μg cm −2 loaded CoO x deposited on anti-corrosive Ti substrate in 1 M KOH with and without various cations with chloride (X−Cl, X=Li, Na, K). Depth-resolved X-ray absorption spectroscopy and depth-profiling X-ray photoelectron spectroscopy were employed. In a thin sample with ~20 nm thickness, uniform oxidation was observed, but a thicker sample with ~80 nm thickness had active oxidized phases close to the surface and an unexpected inactive Co 0 phase concurrently occupying about three-quarters of the CoO x layer in the depth direction, which accounted for the mass activity loss. The formation of Co 0 in the bulk is attributed to the galvanic replacement reaction between CoO x and the metallic Ti substrate, which is not observed on the carbon substrate. Operando Raman spectroscopy demonstrated that the type of cations rather than Cl − impacts the OER performance likely due to their interaction with superoxo species.}, archive = {J_ANGEW}, author = {Hiroki Komiya and Keisuke Obata and Oki Sekizawa and Kiyofumi Nitta and Ke Xu and Melody Wada and Kazuhiro Takanabe}, doi = {10.1002/anie.202501579}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202501579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mass activity elucidation of cobalt-based oxygen evolution catalysts utilizing depth-resolved spectroscopy in the presence of various cations with chloride}, volume = {64}, year = {2025}, }
• (2025). Activating organic electrode for zinc batteries via adjusting solvation structure of zn ions. ANGEW, 64(16), e202501359. (www)

  @article{ , abstract = {Zinc-organic batteries, combining the low cost and high capacity of Zn anodes with the tunable and sustainable properties of organic cathodes, have garnered significant attention. Herein, we present a zinc-organic battery featuring a poly(benzoquinonyl sulfide) (PBQS) cathode, a Zn anode, and an N,N-dimethylformamide (DMF)-based electrolyte, which delivers a high capacity (200 mAh g −1 ), excellent rate capability, and an ultra-long cycle life (10,000 cycles) when tested with a low PBQS loading (2 mg cm −2 ). The charge storage mechanism in the PBQS cathode involves solvated Zn 2+ adsorption and consequent Zn 2+ coordination with PBQS companied by de-solvation process, as confirmed by in situ FT-IR analysis. However, sluggish Zn 2+ de-solvation leads to a loss of Zn 2+ coordination capacity when tested with higher PBQS loading (8 mg cm −2 ) even at a low current density of 0.2 A g −1 . Remarkably, the addition of 2 % H 2 O to the DMF electrolyte incorporates 0.24 H 2 O into the primary solvation sheath of Zn 2+ , significantly facilitating the de-solvation process. As a result, the PBQS cathode (8 mg cm −2 ) retains its Zn 2+ storage capacity when using the modified electrolyte. This approach offers a new strategy for improving the rate performance of organic electrodes, complementing existing conductivity enhancements.}, archive = {J_ANGEW}, author = {Xiaomeng Yu and Kang Zhou and Chang Liu and Junjie Li and Jing Ma and Lei Yan and Ziyang Guo and Yonggang Wang}, doi = {10.1002/anie.202501359}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202501359}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activating organic electrode for zinc batteries via adjusting solvation structure of zn ions}, volume = {64}, year = {2025}, }
• (2025). Leveraging carbon quantum dot spacers as dual Proton/Electron boosters to upgrade TiO2@Polydopamine photocatalysts for pH-resilient conversion of o2 into H2O2. ANGEW, 64(16), e202501357. (www)

  @article{ , abstract = {Photocatalytic synthesis of H 2 O 2 is a proton-coupled electron transfer (PCET) process, which is generally jeopardized by the kinetic mismatch between photogenerated electron transfer and proton supply. To address the challenge, here we proposed a new core–shell design of nanocomposite catalysts comprising of carbon quantum dot (CD)-topped TiO 2 nanoparticles encapsulated by polydopamine (PDA) shells, which delivered stable catalytic activity across a pH range of 1–9, exhibiting a photocatalytic generation rate of H 2 O 2 that reached 18.14 mmol g −1 h −1 in methanol and 8.66 mmol g −1 h −1 in water. This extraordinary, pH-tolerant photocatalytic generation of H 2 O 2 was benefited from the innovative use of CDs, interspaced between the TiO 2 cores and PDA shells, not only as a reservoir of protons to buffer the local acidic microenvironment but also as a proton/electron dual booster to sustain an excellent kinetic match between the proton and photogenerated electron transfer, thus enabling the O 2 reduction to selectively proceed via two-electron reaction pathway over a wide pH span.}, archive = {J_ANGEW}, author = {Linjia Li and Qijing Bu and Tao Lang and Rui Zhang and Youyu Pang and Yuling Zhang and Yanhong Lin and Dejun Wang and Tengfeng Xie and Dayang Wang}, doi = {10.1002/anie.202501357}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202501357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging carbon quantum dot spacers as dual Proton/Electron boosters to upgrade TiO2@Polydopamine photocatalysts for pH-resilient conversion of o2 into H2O2}, volume = {64}, year = {2025}, }
• (2025). Smart targeting layer on silver nanowire electrodes achieving efficiency breakthroughs in ITO-free conventional flexible organic solar cells. ANGEW, 64(16), e202501270. (www)

  @article{ , abstract = {Silver nanowire (AgNW) electrodes, known for their intrinsic flexibility and tunable optoelectronic properties, have garnered considerable attention for use in flexible organic solar cells (OSCs). However, in conventional OSCs, their low work function (WF) causes energy-level mismatches with classic aqueous hole transport layers (HTLs), while their poor hydrophilicity hinders the formation of optimized HTL morphology and crystallinity, posing challenges to their integration into high-performance OSCs. To address these issues, functionally targeted molecules with a thiol group at one end and strong electron-withdrawing, hydrophilic functional groups at the other are precisely engineered to wrap around the AgNW electrodes. The thiol group facilitates the formation of robust self-assembled molecules (SAMs) on the AgNW electrodes through stable S−Ag chemical bonds at room temperature. The strong electron-withdrawing groups generate notable molecular and interfacial dipoles that effectively raise the WF of AgNW electrodes. Notably, the hydrophilic groups not only improve electrode wettability but also promote strong hydrogen bonding interactions with HTL, leading to substantial improvements in the morphology and crystallinity of the HTL. This precision wrapping strategy enables the fabrication of high-efficient conventional flexible OSCs, achieving a record power conversion efficiency of 18.84 % (certified at 18.56 %) for flexible OSCs based on ITO-free transparent electrodes.}, archive = {J_ANGEW}, author = {Jinfeng Xia and Juan Zhu and Haiyang Chen and Guang Zeng and Juanyong Wan and Ben Zhang and Seunglok Lee and Jiacheng Xu and Jianlei Cao and Xiaoxiao Wu and Junyuan Ding and Leishuo Yang and Weijie Chen and Changduk Yang and Yaowen Li and Yongfang Li}, doi = {10.1002/anie.202501270}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202501270}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Smart targeting layer on silver nanowire electrodes achieving efficiency breakthroughs in ITO-free conventional flexible organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Click chemistry: The certainty of chance (Nobel lecture)**. ANGEW, 64(16), e202501229. (www)

  @article{ , archive = {J_ANGEW}, author = {K. Barry Sharpless and M. G. Finn and Hartmuth C. Kolb}, doi = {10.1002/anie.202501229}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202501229}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Click chemistry: The certainty of chance (Nobel lecture)**}, volume = {64}, year = {2025}, }
• (2025). Regulating the spatially folded arrangement of donor and acceptor units to achieve efficient orange-red thermally activated delayed fluorescence. ANGEW, 64(16), e202501179. (www)

  @article{ , abstract = {Achieving efficient long-wavelength organic light-emitting diodes (OLEDs) remains a challenge due to the energy gap law, which leads to increased non-radiative decay rates as the emission wavelength shifts to longer regions. Herein, a strategy of constructing folded three-dimensional architectures is proposed to explore new orange-red thermally activated delayed fluorescence (TADF) emitters with through-space charge transfer characteristics. Innovatively, naphthalene is selected as a bridge to connect O-bridged triphenylamine donor and planar dibenzo[a,c]phenazine acceptor respectively via simple Suzuki–Miyaura Coupling. In this way, a series of rigid orange-red emitters with “U”-shaped, folded “Z”-shaped and “W”-shaped configurations are elaborately constructed by modifying end groups, adjusting the numbers of naphthalene and donor, and regulating the linkage sites. The excited state natures and photophysical properties of the emitters can be effectively regulated and optimized by changing three-dimensional architectures. Finally, the prepared emitter QX36 achieves a lower non-radiative transition rate, a higher radiative rate and a higher photoluminescence quantum efficiency. Solution-processed OLEDs based QX36 present the excellent electroluminescent performance with a maximum external quantum efficiency (EQE) of up to 32.3 % and EQE of 20.6 % at 1000 cd m −2 , which are the leading values of solution-processed orange-red OLEDs. This work demonstrates the promising potential of folded TADF based naphthalene backbone as emitters for future efficient solution-processed long-wavelength OLEDs.}, archive = {J_ANGEW}, author = {Maoqiu Li and Lei Hua and Jinyang Zhao and Yuchao Liu and Shouke Yan and Zhongjie Ren}, doi = {10.1002/anie.202501179}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202501179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating the spatially folded arrangement of donor and acceptor units to achieve efficient orange-red thermally activated delayed fluorescence}, volume = {64}, year = {2025}, }
• (2025). Step-edge guided homoepitaxy enables highly reversible zn Plating/Stripping. ANGEW, 64(16), e202501176. (www)

  @article{ , abstract = {Metal anodes are of profound impact towards the realization of energy-dense rechargeable batteries. However, the “hostless” metal redox always presents the disordered plating/stripping, aggravated by the side reactions and local anisotropy that cause the formation of excessive dendrites/voids and quickly lead to battery failure. Here we report step-edge guided homoepitaxy enabling ordered layer-by-layer Zn plating/stripping regardless of the (dis)charging conditions. Through engineering the atomic terrace height on the mono-oriented Zn(0002) foil anodes, both in-plane and out-of-plane epitaxy aligned to the underlying Zn lattice are demonstrated via the favored edge nucleation and strong interfacial interaction driven by the surface/interface energy minimization, achieving the electrochemical homoepitaxy of continuous, submillimeter-scale Zn(0002) crystal with nearly 100 % theoretical density. Accordingly, we achieve a high Coulombic efficiency of 99.8 %, high depths of discharge exceeding 51 % and 82 % along with record-high lifetimes of over a thousand and hundreds of hours, respectively, in zinc metal batteries. The breakthrough results provide new insights on the intrinsic metal plating/stripping from the view of reversible homoepitaxy for rechargeable energy-dense metal batteries.}, archive = {J_ANGEW}, author = {Shuang Chen and Zhen Luo and Yufan Xia and Xingxing Wu and Kebing Wang and Mi Yan and Hongge Pan and Ben Bin Xu and Yinzhu Jiang}, doi = {10.1002/anie.202501176}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202501176}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Step-edge guided homoepitaxy enables highly reversible zn Plating/Stripping}, volume = {64}, year = {2025}, }
• (2025). Efficient methane purification using a robust and recoverable hydrogen-bonded organic framework. ANGEW, 64(16), e202500970. (www)

  @article{ , abstract = {Efficient separation and purification of methane is a key step in promoting its wide application as an environmentally friendly energy carrier and an important chemical raw material. Development of single solid adsorbents simultaneously combining robust structure, high separation capacity, and easy performance recovery is highly desired but quite a challenge for realizing methane depuration. In the present study, we report an ultramicroporous hydrogen-bonded organic framework compound constructed from a tetracyano bithiophene-functionalized ligand. Similar to the acting principle of enzymes, multisite supramolecular interactions endow the material with not only extraordinary chemical stability in wide pH range including 12 M HCl and 20 M NaOH solutions but also highly selective recognition of acetylene and carbon dioxide over methane. The packing densities and adsorption selectivities toward acetylene and carbon dioxide are the highest reported for the hydrogen-bonded organic framework materials. Dynamic breakthrough experiments demonstrate its highly efficient methane purification ability from binary and even ternary mixed gases, with not only methane productivities up to 2.34 mol kg −1 but also moderate regeneration energy. Furthermore, the title compound can be easily regenerated in almost quantitative yield via simple rato-evaporation of its dichloromethane solution once its activity is attenuated or lost.}, archive = {J_ANGEW}, author = {Shengjie Lin and Ye Liang and Peiren Ke and Limin Wang and Deli Chen and Lin Zhang and Yabing He}, doi = {10.1002/anie.202500970}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500970}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient methane purification using a robust and recoverable hydrogen-bonded organic framework}, volume = {64}, year = {2025}, }
• (2025). Multicomponent reaction integrating Selenium(II)–Nitrogen exchange (SeNEx) chemistry and copper-catalyzed Azide–Alkyne cycloaddition (CuAAC). ANGEW, 64(16), e202500942. (www)

  @article{ , abstract = {Multicomponent reactions (MCRs) are powerful tools for rapidly constructing compound libraries with sufficient molecular diversity and complexity. Herein, to fully leverage a third aspect of molecular diversity enabled by the selenium–nitrogen exchange (SeNEx) reaction between alkynes and benzoselenazolones, a novel CuI-catalyzed three-component reaction has been successfully developed. This reaction integrates SeNEx with CuAAC click chemistry, enabling rapid and regioselective synthesis of 1,4,5-trisubstituted 5-seleno-1,2,3-triazoles with high atom economy and good to excellent yields (65 examples, 50%–95%). Notably, this MCR demonstrates excellent functional group tolerance and features modular, predictable, robust, mild reaction conditions, and operational simplicity (air and water compatibility). Extensive mechanism studies have revealed that this reaction proceeds by a unique SeNEx-CuAAC tandem reaction pathway, distinguishing it from conventional copper(I)-catalyzed interrupted click reactions. Importantly, a mononuclear σ-bound copper(I)-acetylide Cu1 was synthesized and confirmed to be an efficient catalyst for the SeNEx reaction. This discovery provides crucial mechanistic insights into the preferential reactivity of alkynyl groups toward SeNEx over CuAAC. Furthermore, preliminary biological activity screening identified compound 14 as a potent inhibitor of Escherichia coli -glucuronidase (EcGUS), with an IC 50 value of 3.16 µM. These findings underscore the significant potential of this MCR in synthetic chemistry, medical chemistry, and chemical biology.}, archive = {J_ANGEW}, author = {Wei Hou and Xiaohui Zhou and Zhikun Yang and Huhui Xia and Yan Wang and Keren Xu and Shaoneng Hou and Shuning Zhang and Dongmei Cui and Peixiang Ma and Wei Zhou and Hongtao Xu}, doi = {10.1002/anie.202500942}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500942}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multicomponent reaction integrating Selenium(II)–Nitrogen exchange (SeNEx) chemistry and copper-catalyzed Azide–Alkyne cycloaddition (CuAAC)}, volume = {64}, year = {2025}, }
• (2025). Triplet exciplex mediated multi-color ultra-long afterglow mate-rials. ANGEW, 64(16), e202500847. (www)

  @article{ , abstract = {Organic long-lived phosphorescent materials demonstrating ultra-long photoluminescence have practical advantages owing to their flexible design and easy processability. However, the exact photophysical process underpinning the persistent-luminescent continues to elude full understanding, and the principles governing the compatibility of hosts and guests remain elusive. In this work, a new type of nonradiative energy transfer mechanism is proposed for the bi-component RTP system. Different from Förster resonance energy transfer or Dexter-type energy transfer, this energy transfer mechanism primarily relies on a triplet exciplex to exchange the electron. This facilitates the formation of triplet excitons that are otherwise difficult to excite directly. An evaluation methodology is devised to gauge the potential of a specific dopant-host combination toward generating pronounced afterglow. According to this framework, the enhancement of the afterglow is proportional to the decrease in the activation energy (Δ G ≠ ) associated with the electron transfer reaction between the dopant and the host. Notably, when the Δ G ≠ too larger, no observable afterglow occurs, as higher Δ G ≠ values significantly impede the electron transfer reaction between the two components. Furthermore, the remarkable dependence of afterglow intensity on the dopant concentration renders the bi-component RTP system highly promising for applications requiring ultra-high sensitivity and broad-spectrum detection capabilities.}, archive = {J_ANGEW}, author = {Liangwei Ma and Yiwei Liu and Xin Jin and Tao Jiang and Lei Zhou and Qiaochun Wang and He Tian and Xiang Ma}, doi = {10.1002/anie.202500847}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triplet exciplex mediated multi-color ultra-long afterglow mate-rials}, volume = {64}, year = {2025}, }
• (2025). Spin state regulation for peroxide activation: Fundamental insights and regulation mechanisms. ANGEW, 64(16), e202500791. (www)

  @article{ , abstract = {Peroxides are widely used in environmental applications due to their strong oxidizing properties, however, traditional activation methods often face challenges such as uncontrolled reactive oxygen species (ROS) generation and high energy barriers. Recent advancements in spin state regulation provide a promising alternative to enhance the efficiency of peroxide activation. This review provides an overview of spin fundamentals and discusses the key factors affecting spin state in catalytic materials, including crystal field configuration, ligand environment, and valence changes. Subsequently, the role of electron spin state in peroxide activation is comprehensively analyzed, with a focus on how spin state regulation can tune adsorption energy, lower energy barriers, facilitate electron transfer between transition metals and peroxides, and promote selective ROS generation. Finally, this review briefly outlines the practical applications of peroxide activation in water treatment and concludes with a summary and perspectives on future research directions. This review aims to provide a comprehensive perspective on the role of spin state regulation in advancing peroxide activation strategies.}, archive = {J_ANGEW}, author = {Zicong Jiang and Kangbo Tong and Zhi Li and Hengcong Tao and Mingshan Zhu}, doi = {10.1002/anie.202500791}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500791}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spin state regulation for peroxide activation: Fundamental insights and regulation mechanisms}, volume = {64}, year = {2025}, }
• (2025). Extendable synthesis of organic cations for in situ construction of hybrid metal halides with near-unity photoluminescence and strong second harmonic generation. ANGEW, 64(16), e202500786. (www)

  @article{ , abstract = {The A-site organic components of organic–inorganic hybrid metal halides (OIHMHs) significantly impact their crystal structure and optoelectronic properties. However, chemical modification of A-site cations has been mostly limited to commercial organic precursors, which restricts the structural variability of OIHMHs for optimal functionalities. Herein we have proposed an extendable synthesis approach to the direct procurability of various organic cations with desireable structures for the in situ construction of a library of OIHMH materials. The template condensation reaction between dimethyl sulfoxide and acetone derivatives yields A-site organic cations with exquisite control of modularization and regioselectivity within the OIHMH crystallization system. The as-fabricated OIHMHs demonstrated highly efficient linear optical photoluminescence or nonlinear optical second harmonic generation, promising potential applications in photonic devices. This in situ synthetic strategy offers a structural extension of OIHMHs and establishes a fundamental methodological platform for screening functional OIHMH materials.}, archive = {J_ANGEW}, author = {Wenqing Han and Puxin Cheng and Junjie Guan and Quanwen Li and Yue Wang and Zhihua Wang and Theo Rasing and Yongshen Zheng and Jialiang Xu and Xian-He Bu}, doi = {10.1002/anie.202500786}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Extendable synthesis of organic cations for in situ construction of hybrid metal halides with near-unity photoluminescence and strong second harmonic generation}, volume = {64}, year = {2025}, }
• (2025). Polar three-dimensional organic-inorganic hybrid perovskite realize highly sensitive self-driven ultraviolet photodetection. ANGEW, 64(16), e202500765. (www)

  @article{ , abstract = {Bulk photovoltaic effect (BPVE) triggered by spontaneous polarization in polar organic–inorganic hybrid perovskites (OIHPs) has brought unprecedented development opportunities for self-powered ultraviolet photodetection. However, the currently reported ultraviolet optoelectronic devices are dominated by low-dimensional hybrid perovskites, in which low carrier mobility limits the photoelectric conversion efficiency. Herein, we report for the first time a polar three-dimensional OIHPs, namely MHyPbBr 3 ( 1 , MHy=methylhydrazine), that achieves high-performance self-driven ultraviolet photodetection. Benefitting from the large spontaneous polarization and excellent semiconductor attributes, 1 exhibits 0.33 V BPVE and high carrier mobility lifetime product ( μτ ) of 1.972×10 −3 cm −2 V −1 under ultraviolet illumination. Notably, such merits contribute to efficient self-driven photodetection, where responsivity ( R ) and detectivity ( D *) reach up to 198 mA W −1 and 1.42×10 13 Jones, surpassing most reported ultraviolet photodetectors. Furthermore, based on the reversible phase transition of 1 , we have achieved controllable ultraviolet photoelectric detection. This work will shed light on the fabrication of high-response self-driven ultraviolet optoelectronic devices.}, archive = {J_ANGEW}, author = {Hang Li and Zicong Wang and Qianwen Guan and Chengmin Ji and Ruiqing Li and Huang Ye and Zhenyue Wu and Chengshu Zhang and Junhua Luo}, doi = {10.1002/anie.202500765}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500765}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polar three-dimensional organic-inorganic hybrid perovskite realize highly sensitive self-driven ultraviolet photodetection}, volume = {64}, year = {2025}, }
• (2025). Enhanced interfacial electric field of an S-scheme heterojunction by an ultrasonication-triggered piezoelectric effect for sonocatalytic therapy of bacterial infections. ANGEW, 64(16), e202500441. (www)

  @article{ , abstract = {Sonodynamic therapy indicates advantages in combating antibiotics-resistant bacteria and deep tissue infections, but challenges remain in the less efficient charge transfer and reactive oxygen species (ROS) generation of sonosensitizers. Herein, an effective bactericidal strategy is developed through enhancing the interfacial electric field (IEF) of S-scheme heterojunctions by an ultrasonication-triggered piezoelectric effect. Hollow barium titanate (hBT) nanoparticles (NPs) were prepared through template etching, followed by in situ assembly of tetrakis (4-carboxyphenyl)porphyrin (TCPP) with Zn 2+ to obtain hBT@ZnTCPP. Both experimental and theoretical evidences support the notion that an IEF is generared from ZnTCPP to hBT. Compared to metalloporphyrins with Fe 3+ , Mn 3+ , Cu 2+ and Ni 2+ , the stronger reduction of ZnTCPP induced by elevation of the orbital energy level of porphyrins after Zn 2+ coordination leads to formation of S-scheme heterojunctions. The ultrasonication-activated polarization field enhances IEF and boosts energy band bending of hBT@ZnTCPP to promote electron-hole separations and ROS generations. Planktonic methicillin-resistant Staphylococcus aureus and their derived biofilms are completely destroyed within 5 min under ultrasonication through up-regulating genes of glucose catabolism and ion transportation and down-regulating genes of ribosomal synthesis and transmembrane transporter. Thus, this study demonstrates molecular-level modulation of energy levels for S-scheme heterojunction formation to achieve efficient sonocatalytic therapy of bacterial infections.}, archive = {J_ANGEW}, author = {Junwu Wei and Guiyuan Zhang and Shuang Xie and Zhanlin Zhang and Tianyu Gao and Mengxue Zhang and Xiaohong Li}, doi = {10.1002/anie.202500441}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500441}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced interfacial electric field of an S-scheme heterojunction by an ultrasonication-triggered piezoelectric effect for sonocatalytic therapy of bacterial infections}, volume = {64}, year = {2025}, }
• (2025). Ether-embedded covalent organic frameworks enable efficient photocatalytic CO2 reduction. ANGEW, 64(16), e202500329. (www)

  @article{ , abstract = {The photocatalytic conversion of carbon dioxide (CO 2 ) into valuable solar fuels is a promising strategy for addressing energy crises and mitigating the greenhouse effect. However, the challenge of efficiently regulating photogenerated electrons to CO 2 active sites remains a key hurdle for high-performance CO 2 reduction. Herein, an embedded functional group, ether group is introduced into porphyrin-triazine COFs to regulate the transfer behavior of photogenerated electrons. The ether-embedded COFs (TOT-TAPP, BOD-TAPP and QOB-TAPP) demonstrate significantly faster charge transport and higher photoactivity compared with the corresponding non-ether-embedded counterpart COFs. The theoretical calculations and in situ characterizations reveal that the ether group could not only accelerate the separation of photogenerated charge carriers, but also lead to a more substantial accumulation of electrons at the CO 2 adsorption region (C=N imine bond), thus greatly promoting the efficiency of CO 2 photoreduction.}, archive = {J_ANGEW}, author = {Desen Zhou and Qi Chen and Jun Zhang and Tielin Wang and Zhao-Qing Liu}, doi = {10.1002/anie.202500329}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500329}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ether-embedded covalent organic frameworks enable efficient photocatalytic CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Abnormal blueshift of mn d−d emission unlocked by decreasing phonon coupling under high pressure. ANGEW, 64(16), e202500318. (www)

  @article{ , abstract = {Mn d−d emission has been a star transition-metal activated phosphors that were extensively used in optoelectronic devices. However, due to the complex and elusive luminescence mechanism, the full potential of this material remains largely untapped. Here, we designed a core–shell structure of MnS@CdS quantum dots (QDs) to investigate the effect of the internal strain on the Mn emission. Upon pressure processing, an unexpected blueshift of Mn emission was achieved. When the pressure reached a pressure of 2.1 GPa, the conventional redshift of Mn emission reappeared. Remarkable color transition from red to orange and then back to red was observed during pressure treatment. Further analysis revealed that the application of external pressure facilitated the diffusion of Mn atoms into the CdS shell, strengthened host-dopant coupling and mitigated the lattice mismatch rate within the MnS@CdS QDs. These factors resulted in a reduction in phonon coupling strength and an increase in energy transfer efficiency from the exciton of the CdS host lattice to the Mn dopants, thus ultimately accounting for the abnormal blueshift of Mn d−d emission. Our findings represent a significant breakthrough in the quest for precise control and regulation of Mn-related emission, offering insights into the underlying luminescence mechanism of Mn emission.}, archive = {J_ANGEW}, author = {Feng Wang and Pengfei Lv and Guanjun Xiao and Bo Zou}, doi = {10.1002/anie.202500318}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500318}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Abnormal blueshift of mn d−d emission unlocked by decreasing phonon coupling under high pressure}, volume = {64}, year = {2025}, }
• (2025). Multifunctional polymer interphase with fast kinetics for ultrahigh-rate zn metal anode. ANGEW, 64(16), e202500295. (www)

  @article{ , abstract = {Polymer interphase on Zn anodes obviates dendrite growth and significant side reactions including corrosion and hydrogen evolution in aqueous zinc ion batteries (AZIBs), however has drawbacks of slow kinetics and large overpotential for Zn plating/stripping that prevent practical application especially under high-rate conditions. Here, a multifunctional polymer interphase with fast kineticsis reported, using poly(phenazine-alt-pyromellitic anhydride) (PPPA) as an electrolyte additive. PPPA, with linear π-conjugated structure and enriched polar pyridine (conjugated cyclic −C=N−) and carbonyl (C=O) groups, preferentially adsorbs on the Zn anode to form a stable solid-electrolyte interphase (SEI) layer in situ. The PPPA SEI is efficient to block direct contact between water molecules and Zn anode, and regulate the interfacial solvation structure and Zn depostion. Importantly, the expanding π-conjugated structure of PPPA is shown to provide abundant 2D open channels for rapid Zn 2+ transport, and the delocalized π electrons form a space electrostatic field to facilitate de-solvation and diffusion of Zn 2+ . As a result, the Zn metal anode with PPPA/ZnSO 4 electrolyte exhibits high Coulombic efficiency of 98.3 % at current density of 20 mA  cm −2 , and excellent cycle lifespan for over 2000 cycles (400 h) at current density 50 mA cm −2 and plating/stripping capacity of 5 mAh cm −2 . The Zn||MnO 2 full battery exhibited a discharge capacity of 74.4 mAh g −1 after 5000 cycles at the current density of 2000 mA g −1 , demonstrating practical feasibility. It is concluded that judicious engineering of polymer additives and interphase will benefit the development of commercial AZIBs with fast kinetics for high-rate applications.}, archive = {J_ANGEW}, author = {Pan Xue and Can Guo and Wenbin Gong and Yuting Chen and Xiang Chen and Xiaoge Li and Jingyi Yang and Qichong Zhang and Kenneth Davey and Kaiping Zhu and Jianfeng Mao and Zaiping Guo}, doi = {10.1002/anie.202500295}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500295}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multifunctional polymer interphase with fast kinetics for ultrahigh-rate zn metal anode}, volume = {64}, year = {2025}, }
• (2025). Unraveling the essential role of consecutive protonation steps in photocatalytic CO2 reduction when using au nanorods in a MOF. ANGEW, 64(16), e202500269. (www)

  @article{ , abstract = {The proton-coupled electron transfer process (PCET) plays a crucial role in both natural and artificial photosynthesis, including CO 2 fixation chemistry. However, difficulties in capturing the transient intermediates generated during the protonation process impede the clarification of the fundamental mechanism behind photocatalytic CO 2 reduction. Herein, we report a general killing two birds with one stone strategy by spatially confining Au nanorods within a typical porphyrin metal–organic framework (MOF). Interestingly, 2.4-fold increase in CH 4 /CO selectivity and 12-fold increase in CH 4 production were observed after loading of Au nanorods, indicative of a strengthened protonation process in the photocatalytic CO 2 reduction. More importantly, the plasmonic effect from Au nanorods simultaneously boosted the in situ Raman signals of *CO and *CHO intermediates on the Au−O−Zr active site. The evident protonation process was further clarified in a control H/D kinetic isotope experiment. This work highlights the significance of successive protonation steps for boosting CH 4 production in photocatalytic CO 2 reduction.}, archive = {J_ANGEW}, author = {Tianyi Huang and Jianyu Han and Zhongqiu Li and Yixin Hong and Xiaofei Gu and Yafeng Wu and Yuanjian Zhang and Songqin Liu}, doi = {10.1002/anie.202500269}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the essential role of consecutive protonation steps in photocatalytic CO2 reduction when using au nanorods in a MOF}, volume = {64}, year = {2025}, }
• (2025). Oxygen-coordinated single-atom nickel catalysts derived from water-induced Metal–Organic framework aerogel for efficient water oxidation. ANGEW, 64(16), e202500261. (www)

  @article{ , abstract = {Research on metal–organic framework (MOF) aerogels is relatively scarce, primarily constrained by the limited availability of synthetic methods. Herein, a water-induced rapid conversion process of MOF powder to MOF aerogel is demonstrated, where the macroscopic transition is essentially due to the reassembly of microscopic constituent units and the rapid alteration of morphological structure. The derived catalyst possesses abundant holes left by the acid leaching process, leading to the high enrichment of O-coordinated single-atom Ni sites on the concomitant carbon edges. Consequently, such a catalyst exhibits excellent catalytic activity for oxygen evolution reaction (OER) in alkaline media, only requiring a low overpotential of 279 mV to drive the benchmark current density of 10 mA cm −2 . Density functional theory calculations further reveal the reduced OER energy barrier over the edge-enriched O-coordinated single-atom Ni sites, as compared with internal O-coordinated sites and traditional N-coordinated sites. This is primarily attributed to the optimization effect of distinctive O-coordinated structure and synergistic edge effect on the electronic structure of active Ni centers.}, archive = {J_ANGEW}, author = {Jiawei Zhu and Jia-Wei Zhao and Deyan Luan and Xiong Wen (David) Lou}, doi = {10.1002/anie.202500261}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500261}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen-coordinated single-atom nickel catalysts derived from water-induced Metal–Organic framework aerogel for efficient water oxidation}, volume = {64}, year = {2025}, }
• (2025). Multiple deuterium atom transfer perdeuteration of unactivated alkenes under base-assisted Cobalt/Photoredox dual catalysis. ANGEW, 64(16), e202500233. (www)

  @article{ , abstract = {A radical approach for hydrogenative perdeuteration of unactivated alkenes under cobalt/photoredox dual catalysis is described. The addition of a suitable base plays a key role in controlling two competing pathways by switching the catalytic performance of cobalt/photoredox catalysis. Base-assisted cobalt/photoredox dual catalysis promoted a hydrogen isotope exchange reaction of alkenes to afford deuterated alkenes via multiple repeating deuterium atom transfer/hydrogen atom abstraction processes, while consecutive reductive deuteration of alkenes proceeded in the absence of a base to afford polydeuterated alkanes. One-pot hydrogenative perdeuteration and perdeutero-arylation were also developed, providing access to various polydeuterated aliphatic compounds.}, archive = {J_ANGEW}, author = {Akihiko Suzuki and Kosuke Higashida and Tatsuhiko Yoshino and Shigeki Matsunaga}, doi = {10.1002/anie.202500233}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500233}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple deuterium atom transfer perdeuteration of unactivated alkenes under base-assisted Cobalt/Photoredox dual catalysis}, volume = {64}, year = {2025}, }
• (2025). Preparation of degradable and sequence-controlled aliphatic polysulfones by group transfer radical polymerization. ANGEW, 64(16), e202500153. (www)

  @article{ , abstract = {The incorporation of sulfur atoms into polymer backbones for the synthesis of sulfur-containing polymers, such as aliphatic polysulfones, not only enhances degradability but also imparts many distinctive properties to these materials. Traditional synthetic methods encounter substantial challenges in achieving sequence-controlled aliphatic polysulfones with high molecular weights (MW), which significantly limits their applications. We report a novel approach for synthesizing aliphatic polysulfones using the strategy of sulfonyl radical-mediated group transfer radical polymerization (GTRP). This protocol employs a practical SO 2 -free pathway and produces a series of ABC sequence-defined high-MW polymers (up to 199.2 kg/mol). The resultant aliphatic polysulfone exhibits remarkable full-degradability at ambient temperature under strong basic conditions, and offers optical properties – including refractive index and Abbe number – comparable to those of commercially utilized polycarbonate. Additionally, density functional theory (DFT) calculations have been performed to corroborate the non-desulfonylative Smiles rearrangement mechanism implicated in the GTRP process.}, archive = {J_ANGEW}, author = {Kexiong Gao and Xianjin Wang and Tongkun Wang and Silin Song and Chen Zhu}, doi = {10.1002/anie.202500153}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500153}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Preparation of degradable and sequence-controlled aliphatic polysulfones by group transfer radical polymerization}, volume = {64}, year = {2025}, }
• (2025). The ratio of sp2 and sp3 hybridized carbon determines the performance of carbon-based catalysts in H2O2 electrosynthesis from o2. ANGEW, 64(16), e202500145. (www)

  @article{ , abstract = {Introducing oxygen- or carbon-containing functional groups is a widely adopted strategy to optimize the performance of carbon-based catalysts for the two-electron oxygen reduction reaction (2 e − ORR). Nevertheless, the specific contributions of these functional groups to enhance activity and selectivity are not well-defined and continue under debate. In this study, we systematically modified carbon materials by controlling the contents of oxygen functional groups (OFGs) and carbon functional groups (CFGs). Surface compositions were accurately quantified using X-ray photoelectron spectroscopy, and 2 e − ORR performance was evaluated using a rotating ring-disk electrode (RRDE) in 0.1 M KOH. Through reliable statistical analyses, including partial least squares regression and linear regression, we explored the correlations between the surface compositional features – specifically the ratios of OFGs, CFGs, and sp 2 / sp 3 hybridized carbon – and the catalytic performance metrics such as onset potential and H 2 O 2 selectivity. Our findings challenge existing paradigms by demonstrating that the sp 2 / sp 3 ratio is a critical factor in determining catalytic selectivity and a certain correlate with the 2 e − ORR onset potential. By tuning this ratio, we achieved nearly 100 % H 2 O 2 selectivity within 0.4–0.6 V vs. RHE, and onset potential approached the thermodynamic potential (0.766 V vs. RHE for the O 2 /HO 2 - process), pointing a new direction in designing and developing advanced electrocatalysts for sustainable H 2 O 2 synthesis.}, archive = {J_ANGEW}, author = {Dayu Zhu and Hsi-wen Wu and Wye-Khay Fong and Rico F. Tabor and Jie Zhang}, doi = {10.1002/anie.202500145}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202500145}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The ratio of sp2 and sp3 hybridized carbon determines the performance of carbon-based catalysts in H2O2 electrosynthesis from o2}, volume = {64}, year = {2025}, }
• (2025). Integrating two photochromics into one three-dimensional covalent organic framework for synergistically enhancing multiple photocatalytic oxidations. ANGEW, 64(16), e202425668. (www)

  @article{ , abstract = {While photocatalytic oxidations are a category of important reactions in wide chemical synthesis, the fabrication of effective photocatalysts for broad oxidation reactions is still of a great challenge. Herein, by rationally integrating two photochromics, porphyrin and triphenylamine, a three-dimensional photoactive covalent organic framework (COF) is successfully constructed for photocatalytic oxidations. Characterization studies not only show the formation of a crystalline and three-dimensional porous framework, but also reveal its effective photochemical semiconductor properties derived from the porphyrin and triphenylamine moieties. Electron paramagnetic resonance measurements indicate that the COF is an effective photocatalyst for the generation of both singlet oxygen ( 1 O 2 ) and superoxide radical anions (⋅O 2 − ). Synergistically enhanced efficiency in all photocatalytic reactions of photocatalytic aerobic oxidation of alkylbenzenes and silanes as well as thioanisoles, and cross-dehydrogenative coupling reaction of N-phenyltetrahydroisoquinoline and indole is confirmed by both experimental and theoretical studies, demonstrating its promising potential for broad photocatalytic oxidation reactions.}, archive = {J_ANGEW}, author = {Ling-Bao Xing and Ke Cheng and Hailian Li and Kaikai Niu and Tian-Xiang Luan and Shuo Kong and William W. Yu and Pei-Zhou Li and Yanli Zhao}, doi = {10.1002/anie.202425668}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425668}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating two photochromics into one three-dimensional covalent organic framework for synergistically enhancing multiple photocatalytic oxidations}, volume = {64}, year = {2025}, }
• (2025). Spatially separated redox centers in anthraquinone-grafted metal-organic frameworks for efficient piezo-photocatalytic H2O2 production. ANGEW, 64(16), e202425656. (www)

  @article{ , abstract = {Piezo-photocatalytic production of hydrogen peroxide (H 2 O 2 ) from water and air is promising but its large-scale application is still challenging as insufficient reaction active sites and low reaction efficiency. We have applied molecular engineering methods to design an anthraquinone molecularly (AQ) grafted metal–organic framework piezo-photocatalyst (UiO-66-AQ) for H 2 O 2 generation from water and air. The catalyst achieves a peak H 2 O 2 yield of 7872.4 μM g −1 h −1 by facilitating two critical reactions: single-electron water oxidation (WOR) and two-electron oxygen reduction (ORR) on spatially separated redox sites. Experiments and computational simulations reveal efficient charge separation through a ligand-to-chain transfer mechanism. Electrons and holes are selectively transferred to AQ and UiO-66 promoting ORR and WOR under ultrasound and visible light. The high reaction rate of ORR (rapid generation of endoperoxide) compensates for the slow kinetics of WOR (generation of OH*) and greatly increases the rate of full-reaction of H 2 O 2 production. Additionally, a continuous flow tubular reactor equipped with UiO-66-AQ catalytic membranes affords 96 % removal of organic dyes by a in situFenton process under visible light and water flow, confirming the significant potential of the catalyst for practical applications. This work deepens the understanding of directional carrier migration at piezo-photocatalytic spatial separation sites, opening new pathways for environmentally friendly and efficient H 2 O 2 synthesis.}, archive = {J_ANGEW}, author = {Cheng Chen and Kaiye Gu and Peifang Wang and Zhao-Qing Liu and Yanhui Ao}, doi = {10.1002/anie.202425656}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425656}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatially separated redox centers in anthraquinone-grafted metal-organic frameworks for efficient piezo-photocatalytic H2O2 production}, volume = {64}, year = {2025}, }
• (2025). NIR-II emissive oligonucleotides grafted π-conjugated polymers for low-temperature photothermal and gene combined therapy. ANGEW, 64(16), e202425654. (www)

  @article{ , abstract = {In order to address the strong hydrophobicity and function limitation of NIR-II emissive phototheranostic π-conjugated polymers (CPs), appropriate modifications are necessary to impart water dispersibility and functionality to CPs. This study uses DNA as the hydrophilic and functional unit to modify CPs, synthesizing CP-g-DNA amphiphilic copolymers and producing water-dispersible oligonucleotide-modified π-conjugated polymer nanoparticles (OCPNs) by self-assembly. In addition to DNA′s gene regulation abilities that can combine with the low-temperature photothermal therapy of CPs for enhanced tumor therapy, OCPNs display unique characteristics as novel nanomaterials. On one side, DNA changes the π–π interactions and results in a two-fold enhancement in NIR-II fluorescence emission, which greatly benefits tumor imaging. On the other side, DNA varies the surface properties of OCPNs and the nano-bio interactions. OCPNs exhibit multiple cellular internalization pathways, including caveolae/lipid raft-mediated uptake for cytoplasm delivery, which may enhance gene transfection combined with the photothermal-promoted lysosome escape. Moreover, OCPNs can quickly accumulate in tumors due to their higher tissue penetration capability. Taken together, a strategy of using DNA to enable and advance the phototheranostic applications of CPs has been demonstrated, and the distinct properties of OCPNs will open up new biological application opportunities in the future.}, archive = {J_ANGEW}, author = {Guiling Fan and Shengxin Hou and Ying Gu and Hengfeng Jiang and Wenkang Zhang and Weitao Wu and Mengying Wang and Leilei Tian}, doi = {10.1002/anie.202425654}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NIR-II emissive oligonucleotides grafted π-conjugated polymers for low-temperature photothermal and gene combined therapy}, volume = {64}, year = {2025}, }
• (2025). Post-deposition treatment of Sb2Se3 enables defect passivation and increased carrier transport dimension for efficient solar cell application. ANGEW, 64(16), e202425639. (www)

  @article{ , abstract = {Post-deposition treatment in thin film preparation can compensate for the inability of directly deposited films by fundamentally altering the chemical, electrical, morphological and defect properties. However, as an emerging photovoltaic material, the synthesis of Sb 2 Se 3 film has so far been unable to effectively adjust the carrier transport and defect properties, thereby hindering performance improvement. In this study, we report that P 2 O 5 can serve as a post-deposition treatment material to modify the chemical and electrical properties of Sb 2 Se 3 thin films. Through experimental analysis, we discover that P atoms from P 2 O 5 can occupy the Se vacancy and convert the deep-level anti-site defect (Sb Se ) to a shallower defect (P Se ), rendering efficient defect passivation. Simultaneously, P-doping induced lattice distortion closes the ribbon spacing of (Sb 4 Se 6 ) n , promoting efficient carrier transport from one dimension to three dimensions. This structure reduces the restriction of carrier transport in low-dimensional materials, which suppresses the carrier non-radiative recombination and improves the carrier transport efficiency. As a result, we achieved a champion power conversion efficiency of 9.50 % in thermal evaporation derived Sb 2 Se 3 superstrate solar cells. This study provides a novel strategy and guidance for passivating deep-level defects and modifying the crystal structure of low-dimensional solar cell materials.}, archive = {J_ANGEW}, author = {Bo Che and Zhiyuan Cai and Haonan Xu and Shuwei Sheng and Qi Zhao and Peng Xiao and Junjie Yang and Changfei Zhu and Xusheng Zheng and Rongfeng Tang and Tao Chen}, doi = {10.1002/anie.202425639}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425639}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Post-deposition treatment of Sb2Se3 enables defect passivation and increased carrier transport dimension for efficient solar cell application}, volume = {64}, year = {2025}, }
• (2025). Synergistic zn and MoS2 tailored Co−N/C environments enabling bifunctional ORR/OER electrocatalysis for advanced Li−O2 batteries. ANGEW, 64(16), e202425502. (www)

  @article{ , abstract = {To better adapt lithium-oxygen batteries (LOBs) and overcome their sluggish oxygen reduction and evolution reactions (ORR/OER) kinetics, designing efficient bifunctional ORR/OER catalytic materials is essential. In this study, we successfully constructed a bifunctional ZnCo−N/C@MoS 2 catalyst by tailoring the Co−N/C center with Zn incorporation and MoS 2 encapsulation. Surprisingly, Zn atoms, which are typically considered to promote the Co atoms isolation, exhibit a promoting effect on the ORR performance of Co−N/C centers and enhance their stability under harsh conditions. Introducing MoS 2 establishes Mo−N coupling centers, enhancing electron transfer and adjusting the charge density of Co active centers, thereby compensating OER activity limitation of ZnCo−N/C. In Li−O 2 batteries, Zn and MoS 2 synergistically optimize intermediate interactions and regulate LiO 2 formation/decomposition, while Zn′s environmental adaptability and MoS 2 ′s encapsulating protection jointly enhance operational stability. Results show that ZnCo−N/C@MoS 2 , serving as the oxygen electrode in Li−O 2 batteries, achieves a low overpotential of 1.01 V, an ultra-high specific capacity of 25,026 mAh g −1 , and a long cycle life of 298 cycles. This work achieves bifunctionality in single-atom catalysts through precise dual modulation of the catalytic environment, providing a novel strategy for the development of lithium-oxygen batteries.}, archive = {J_ANGEW}, author = {Zhiyang Wang and Qi Zhang and Wenhong Liu and Hao Luo and Xianghua Kong and Qingchun Yang and Dawei Zhang and Yan Yu}, doi = {10.1002/anie.202425502}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic zn and MoS2 tailored Co−N/C environments enabling bifunctional ORR/OER electrocatalysis for advanced Li−O2 batteries}, volume = {64}, year = {2025}, }
• (2025). Efficient infrared-detecting organic semiconductors featuring a tetraheterocyclic core with reduced ionization potential. ANGEW, 64(16), e202425420. (www)

  @article{ , abstract = {Infrared organic semiconductors are crucial in organic optoelectronics, yet high-performance materials with photoresponse beyond 1.1 μm (the limit of crystalline silicon) remain scarce due to the limit of building blocks including strong electron-donating units. Here, we report an asymmetric tetraheterocycle (TPCT) with a reduced ionization potential of 6.18 eV relative to those reported dithiophene-based electron-donating blocks, and TPCT-2F and TPCTO-2F constructed with TPCT as the core exhibit absorption onset up to 1 μm and 1.4 μm, respectively. Especially, TPCTO-2F possesses a narrow band gap of 1.00 eV and displays a small Urbach energy of 22.0 meV comparable to or even lower than those of some typical inorganic short-wave infrared (SWIR) semiconductors (13–44 meV). The organic photodetectors (OPDs) based on TPCT-2F achieve a peak detectivity ( D *) of 2.2×10 13 Jones at 810 nm under zero bias, among the highest values for reported OPDs and on par with commercial silicon photodetectors. Impressively, TPCTO-2F-based OPDs demonstrate a wide response from 0.3 to 1.4 μm and high D * comparable to germanium photodetector at wavelengths <1.2 μm with a maximum D * of 2.3×10 11 Jones at 1.06 μm in SWIR region.}, archive = {J_ANGEW}, author = {Huiqing Hou and Wei Wang and Tengfei Li and Zhenzhen Zhang and Xiaodan Miao and Guilong Cai and Xinhui Lu and Yuanping Yi and Yuze Lin}, doi = {10.1002/anie.202425420}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425420}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient infrared-detecting organic semiconductors featuring a tetraheterocyclic core with reduced ionization potential}, volume = {64}, year = {2025}, }
• (2025). Redirecting on-surface cycloaddition reactions in a self-assembled ordered molecular array on graphite. ANGEW, 64(16), e202425185. (www)

  @article{ , abstract = {The synthesis of atomically precise carbon nanostructures in ultra-high vacuum has seen extensive progress on metal surfaces. However, this remains challenging on chemically inert surfaces. It is because the thermally activated C−C coupling encounters a severe “desorption problem” on weakly interacting substrates. In this study, we report an extraordinary [2+2]+[2+2] cycloaddition triggered by mild annealing (~210°C) in a highly ordered π-conjugated molecular array on graphite using scanning tunneling microscopy. In contrast to irregular dendritic fragments typically obtained on metal substrates, large supramolecular islands are observed here with cycloaddition products and other polymers over 30 %, which are embedded as defective individuals or chains (grain boundaries). First-principles calculations reveal that the energy barriers of the multiple dehydrohalogenation and cycloaddition reactions are reduced by catalytic Fe atoms but remain energetically unfavorable. A distinct driving mechanism is proposed for redirecting the reactions on graphite surface, where additional intermolecular coupling, steric hindrance, and interfacial interactions play significant roles. This study introduces a new paradigm for understanding on-surface synthesis on non-metal substrates.}, archive = {J_ANGEW}, author = {Yu Li Huang and Ke Yang and Jing Yang and Sisheng Duan and Yihe Wang and Mingyue Sun and Yong-Wei Zhang and Ming Yang and Andrew Thye Shen Wee}, doi = {10.1002/anie.202425185}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425185}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redirecting on-surface cycloaddition reactions in a self-assembled ordered molecular array on graphite}, volume = {64}, year = {2025}, }
• (2025). Photo-patternable and healable polymer semiconductor enabled by dynamic covalent disulfide bonding. ANGEW, 64(16), e202425172. (www)

  @article{ , abstract = {Apart from charge transport property, polymer semiconductors with patternable and healable functions are highly demanding for the fabrication of organic circuits. Herein, by leveraging the dynamic covalent disulfide bonding of thioctic acid (TA) groups, we successfully integrate photo-patterning and thermal-healing capabilities into a single diketopyrrolopyrrole (DPP)-based polymer semiconductor for the first time. The results show that the thin film of DPP-based conjugated donor-acceptor polymer with TA groups in the side chains exhibits excellent photo-patterning capability under 365 nm UV light irradiation, with sensitivity ( S ) of 210 mJ⋅cm −2 and contrast ( γ ) of 1.2. Importantly, the patterning process has minimal impact on thin film morphology, interchain stacking, and charge transport mobility. Moreover, the patterned thin films, which were initially scratched, can be well healed after exposure to chloroform vapor and further thermal annealing, and simultaneously the charge mobility can be restored. In comparison, the scratched thin film of PDPP4T without TA groups in the side chains achieves only 82.6 % recovery of scratch depth and 54.5 % recovery of charge mobility under the same conditions. These results demonstrate the feasibility of constructing multifunctional polymer semiconductors by incorporating TA groups in the side chains, offering a new pathway to lithography-compatible, self-healing smart flexible devices.}, archive = {J_ANGEW}, author = {Xiang Xue and Cheng Li and Xiaobo Yu and Kaiyuan Chenchai and Xinyue Zhang and Xisha Zhang and Guanxin Zhang and Deqing Zhang}, doi = {10.1002/anie.202425172}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425172}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-patternable and healable polymer semiconductor enabled by dynamic covalent disulfide bonding}, volume = {64}, year = {2025}, }
• (2025). Robust fully screen-printed perovskite solar cells based on synergistic ostwald ripening. ANGEW, 64(16), e202425162. (www)

  @article{ , abstract = {Fully screen-printed process for low-cost manufacturing significantly enhances the commercial competitiveness of perovskite solar cells (PSCs). However, the controllable crystallization in screen-printed perovskite thin films using high-viscosity ionic liquids has been suggested to be difficult, which hampers further development of fully screen-printed perovskite devices in terms of application expansion and performance improvement. Here, we report a synergistic ripening strategy to fully control crystallization by employing methylamine propionate (MAPa) ionic liquid and water (H 2 O, moisture in the air). We found that a reversible and sustainable ripening process was activated by integrating MAPa/H 2 O in both externally and internally into perovskite crystals. MAPa effectively prevents the loss of organic salts and maintains the dispersion of Pb-I framework, preventing the perovskite component loss and decomposition. H 2 O and organic salts trends to form hydration complexes, which lowers the energy barrier and enhances the reactivity of the humidity-induced Ostwald ripening reaction. These improvements allow the screen-printed perovskite thin films achieve controlled secondary growth and ion exchange, thereby reducing defects and optimizing energy level alignment. The resulting fully screen-printed PSCs exhibits a record power conversion efficiency of 19.47 % and an operational stability over 1,000 h with maintaining 91.6 % of the highest efficiency under continuous light stress at maximum power point.}, archive = {J_ANGEW}, author = {Changshun Chen and Chunyu Guo and Qing Yao and Jinpei Wang and Yutian Xu and Dengke Wang and Xiao Huang and Xueqin Ran and Yingdong Xia and Lingfeng Chao and Yonghua Chen}, doi = {10.1002/anie.202425162}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust fully screen-printed perovskite solar cells based on synergistic ostwald ripening}, volume = {64}, year = {2025}, }
• (2025). Insights into co-catalytic single-atom-support interactions for boosting sulfur reduction electrocatalysis. ANGEW, 64(16), e202425144. (www)

  @article{ , abstract = {The use of single-atom catalysts (SACs) with abundant electrocatalytic centers has been identified as the most desirable strategy to inhibit the shuttle effect in lithium-sulfur batteries. However, the co-contribution from SAC and its support via their interactions for accelerating the sulfur reduction reactions (SRR) has so far received little attention, since the underlying mechanism remains elusive. Herein, guided by density functional theory calculations, Cobalt-SACs supported on a graphitic carbon nitride substrate (Co-GCN), are selected to elucidate the co-catalytic role in enhancing the SRR. The inherent high charge polarity of GCN, combined with its unique tri-s-triazine structure, offers multiple binding sites for lithium polysulfides (LiPSs) through Li−N bonds, as well as N/C-coordinated frameworks for anchoring Co-SACs. This structural configuration further amplifies the interaction with LiPSs via Co−S bonds. Consequently, both Co-SACs and GCN actively participate in sulfur reduction electrocatalysis by binding LiPS intermediates, lowering the conversion energy barrier of SRR. Benefitting from such unique synergy, the battery demonstrates outstanding rate performance (718.9 mAh g −1 at 5.0 C) and yields a high areal capacity of up to 13.8 mAh cm −2 (1584.3 mAh g −1 ) under a high areal sulfur loading of 8.7 mg cm −2 but a low electrolyte/sulfur ratio of 5.0 μL mg −1 .}, archive = {J_ANGEW}, author = {Tianqi You and Huiyue Sun and Wuxing Hua and Shuang Geng and Zhonghao Hu and Yongqi Shang and Qunzhi Huang and Shuxi Dai and Ke Chen}, doi = {10.1002/anie.202425144}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insights into co-catalytic single-atom-support interactions for boosting sulfur reduction electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). ‘Tearing effect’ of Alloy–Support interaction for alloy redispersion in NiRu/TiO2 hydrogenation catalysts. ANGEW, 64(16), e202425066. (www)

  @article{ , abstract = {Supported alloy catalysts have been extensively applied to many significant industrial chemical processes due to the abundant active sites with distinguishable geometry and electron states. However, a detailed in situ investigation of the interaction between support and alloy nanoparticles is still lacking. Here, a subversive ‘tearing effect’ on the interface of TiO 2 -supported NiRu alloy nanoparticles is in situ discovered by environmental transmission electron microscopy (ETEM) with a dramatic redispersion process of alloy nanoparticles from ~25 nm to 2–3 nm under the repeated hydrogen reduction. Dual-driven by the distinct alloy-support interaction involving the restructuring of alloy nanoparticles and growth of TiO x overlayer, larger NiRu alloy nanoparticles spontaneously disintegrate into atoms migrating on support. Atoms are finally captured by the defects generated on TiO 2 during the repeat reduction, which also confines the further growth of the newly alloy nanoparticles. Owing to this specific alloy-support interaction, smaller alloy nanoparticles on TiO 2 support are much more stable than the bigger ones, which holds promise for industrial applications as durable catalysts. This novel metal-support interaction with the ‘tearing effect’ revealed on supported alloy catalysts provides new knowledge on the structure-performance relationships in all the alloy catalysts for hydrogenation reactions.}, archive = {J_ANGEW}, author = {Sibei Zou and Liwei Cao and Xingmo Zhang and Chaoqi Chen and Mizuki Tada and Satoshi Muratsugu and Rongying Tian and Haoyue Sun and Ang Li and Xiaodong Han and Xiaozhou Liao and Jun Huang and Assaad R. Masri}, doi = {10.1002/anie.202425066}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425066}, shortjournal = {Angew. Chem. Int. Edit.}, title = {‘Tearing effect’ of Alloy–Support interaction for alloy redispersion in NiRu/TiO2 hydrogenation catalysts}, volume = {64}, year = {2025}, }
• (2025). Engineering the catalytic superlattices for highly reversible sodium-ion storage with a high compositional conversion degree. ANGEW, 64(16), e202425063. (www)

  @article{ , abstract = {A major obstacle of transition metal disulfides in sodium-ion batteries is compositional irreversible conversion, leading to fast capacity decay. Here, we propose to engineer a catalytic superlattice structure for achieving a record-high compositional reversible conversion degree (≈100 %). The superlattice is constructed by alternately stacking MoS 2 layers and nitrogen/oxygen co-doped reduced graphene oxide-supported single-atom metal layers (MoS 2 /M-ONG SL, M=Fe, Co, Ni, Cu, Zn) with 100 % MoS 2 /M-ONG interfaces, in which the metal atoms bridge the two layers through S−M-O chemical bonds. Using MoS 2 /Co-ONG SL as a model, the unique superlattice structure shows excellent electron and Na + transport properties during discharge and charge. Moreover, the Co-ONG boosts Na 2 S adsorption and decomposition by forming Co-3d and S-3p hybridization. As a result, the MoS 2 /Co-ONG SL shows a high compositional reversible conversion degree(≈100 %), as proven by a series of in-/ex situ spectroscopic analyses. As a result, the MoS 2 /Co-ONG SL exhibits a stable cycling stability of 300.7 mAh g −1 after 2000 cycles at 2 A g −1 , with an ultrasmall capacity decay rate of 0.41 % per 100 cycles. This work offers a noteworthy perspective on the design and fabrication of conversion-type materials, emphasizing the crucial role of interface engineering in achieving excellent bidirectional reaction kinetics.}, archive = {J_ANGEW}, author = {Jingyi Wang and Tongfeng Liu and Biao Chen and Zijia Qi and Haonan Xie and Guangxuan Wu and Liyang Xiao and Jingwen Zhou and Liying Ma and Fang He and Chunnian He and Wenbin Hu and Naiqin Zhao}, doi = {10.1002/anie.202425063}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202425063}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering the catalytic superlattices for highly reversible sodium-ion storage with a high compositional conversion degree}, volume = {64}, year = {2025}, }
• (2025). The last piece of the puzzle: Access to 7-connected zirconium Metal–Organic frameworks for hexane separation. ANGEW, 64(16), e202424859. (www)

  @article{ , abstract = {Zirconium metal–organic frameworks (Zr-MOFs) exhibit a wide range of Zr 6 cluster connectivities, from 3-connected to 12-connected, enabling diverse structural designs. However, odd-numbered connectivities, especially the 7-connected Zr-MOFs, are exceptionally rare due to geometric symmetry challenges. To address this, we developed a geometric pre-assembly strategy to achieve targeted cluster connectivity. Using this approach, we synthesized NU-5001 {[Zr 6 O 4 (OH) 4 (H4-L) 2 ]}, a Zr-MOF featuring 7-connected Zr 6 clusters, derived from the precursor 6-connected Zr-MOF, NU-5000 {[Zr 6 O 4 (OH) 4 (H3-L) 2 ]}. NU-5000, constructed with a tritopic chiral linker H3-L {( R )-4,4’,4’’-[6’-chloro-2,2’-diethoxy-(1,1’-binaphthalene)-4,4’,6-triyl]tribenzoic acid}, forms a (3,6)-connected ant topology. Introducing a tetratopic chiral linker, 1,1’-bi-2-naphthol tetracarboxylic acid H4-L {( R )-4,4’,4’’,4’’’-[2,2’-diethoxy-(1,1’-binaphthalene)-4,4’,6,6’-tetrayl]tetrabenzoic acid}, enabled an additional connection, resulting in NU-5001 with a (3,4,7)-connected topology. The H4-L linker acts as either fully 4-connected or 3-connected with one arm uncoordinated. Additionally, NU-5001M {[Zr 6 O 4 (OH) 4 (H4-L) (H3-L)]}, an isostructural variant, was synthesized using a mix of H3-L and H4-L linkers. NU-5001’s unique pore structure and slight flexibility enable distinct adsorption behaviors for hexane isomers, highlighting its potential for kinetic separations. This work completes the Zr 6 cluster connectivity landscape and demonstrates the feasibility of tuning Zr-MOF connectivities through rational linker design, paving the way for rare, low-symmetry frameworks with tailored properties.}, archive = {J_ANGEW}, author = {Xianhui Tang and Lei Jia and Xiaoliang Wang and Shengyi Su and Yongwei Chen and Xiang-Jing Kong and Zi-Ming Ye and Haomiao Xie and Wei Gong and Enping Du and Yan Liu and Kent O. Kirlikovali and Omar K. Farha and Yong Cui}, doi = {10.1002/anie.202424859}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424859}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The last piece of the puzzle: Access to 7-connected zirconium Metal–Organic frameworks for hexane separation}, volume = {64}, year = {2025}, }
• (2025). Switchable polymerization from monomer mixtures to synthesize oxygen-rich block copolymers with dual recyclability and degradability. ANGEW, 64(16), e202424856. (www)

  @article{ , abstract = {Switchable catalysis from monomer mixtures has been emerging as a powerful technique to synthesize various useful block copolymers, yet represents a significant challenge in polymer chemistry. Herein, we present the synthesis of well-defined polyacetal/polycarbonate block copolymers through switchable polymerization from mixtures of terminal epoxides, internal epoxides, o -phthalaldehyde (OPA) and CO 2 . The exclusive chemoselectivity of terminal epoxide or internal epoxide was achieved by controlling the reaction atmosphere. The dynamic equilibrium of acetal anion and alkoxy anion is the key to the successful switch from terminal epoxides/OPA copolymerization to internal epoxides/CO 2 copolymerization. Computational studies elucidated the kinetic and thermodynamic preferences underlying this selective polymerization. The acid/base labile nature of the block copolymers enables their sequence-controlled chemical recycling/degradation. These novel polyacetal/polycarbonate block copolymers with facilely sequence-controlled polymerization/depolymerization capabilities will enable their further tailored applications and contribute to the development of a circular plastic economy.}, archive = {J_ANGEW}, author = {Di Xie and Zhi-Hua Jia and Yan-Li Zhang and Xin-Lei Cai and Long-Nv Liu and Guan-Wen Yang and Xiaohui Kang and Xianming Zhang and Yao-Yao Zhang}, doi = {10.1002/anie.202424856}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424856}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switchable polymerization from monomer mixtures to synthesize oxygen-rich block copolymers with dual recyclability and degradability}, volume = {64}, year = {2025}, }
• (2025). Unlocking the power of photothermal agents: A universal platform for smart immune NIR-agonists for precise cancer therapy. ANGEW, 64(16), e202424830. (www)

  @article{ , abstract = {Selective ablation of tumor cells allows safe eradication, thereby minimizing off-target damage, while specifically inducing immunogenic cell death (ICD) rather than commonly non-immunogenic apoptosis of tumor cells enables activation of anti-tumor immune response against residual cancer cells, including metastatic lesions. Herein, we present a general strategy leveraging a novel photothermal agent (PTA) that concomitantly enables precise tumor killing and activation of anti-tumor immunity. The unique PTA scaffold exhibits unexpected inherent endoplasmic reticulum (ER)-targeting capability and potent near-infrared (NIR) photothermal activity, inducing NIR-controlled immunogenic pyroptosis in various tumor cell lines via targeting ER stress in an oxygen-independent manner. Moreover, both ER-targeting and NIR-activity of our scaffold can be modulated on demand by chemical caging/uncaging, allowing quick activation with diverse biological and bioorthogonal molecular triggers. The potency of this universal platform is demonstrated via its application to develop a membrane protein-activatable NIR-agonist that selectively activates ICD in tumor sites while priming anti-tumor immunity, minimizing off-target effects and enhancing efficacy against mouse breast tumors. This versatile approach could lead to customization of various personalized and effective immune NIR-agonists for specific photoimmunotherapy applicable to diverse solid tumors.}, archive = {J_ANGEW}, author = {Hao Zhang and Xiaona Xu and Yahui Cao and Zihui Chen and Weiqing Liu and Xinyi Lu and Changhua Li}, doi = {10.1002/anie.202424830}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking the power of photothermal agents: A universal platform for smart immune NIR-agonists for precise cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Inverse electron demand Diels–Alder reaction on M3N@C80 (M=Lu, sc): Reactivity and reversibility enable chemical separation of metallofullerenes. ANGEW, 64(16), e202424776. (www)

  @article{ , abstract = {Endohedral metallofullerenes are chemically more inert compared to empty fullerenes, primarily due to their intramolecular electron transfer. In this work, we report an inverse electron demand Diels–Alder (IEDDA) reaction on M 3 N@C 80 (M=Lu, Sc), where they show significantly higher reactivity than empty fullerenes. The molecular structures of the [4+2] cycloadducts were unambiguously characterized. Moreover, the cycloadducts can fully revert to pristine M 3 N@C 80 via retro-cycloaddition upon thermal treatment. With the unusual reactivity and reversibility, the IEDDA reaction enables an effective separation approach for metallofullerenes from their soot extracts, opening path to efficient and economical scale-up synthesis of metallofullerenes in laboratory and industrial settings.}, archive = {J_ANGEW}, author = {Yue Sun and Laura Abella and Thomas J. Emge and Sheng Zhu and Yanbang Li and Ian Ferraro and Anyin Li and Steven Stevenson and Josep M. Poblet and Antonio Rodríguez-Fortea and Jianyuan Zhang}, doi = {10.1002/anie.202424776}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inverse electron demand Diels–Alder reaction on M3N@C80 (M=Lu, sc): Reactivity and reversibility enable chemical separation of metallofullerenes}, volume = {64}, year = {2025}, }
• (2025). Practical high-voltage lithium metal batteries enabled by the in-situ fabrication of main-chain fluorinated polymer electrolytes. ANGEW, 64(16), e202424685. (www)

  @article{ , abstract = {Polymer electrolytes are crucial for advancing safe, high-energy-density lithium batteries. Therefore, such electrolytes must possess stability with high-voltage cathodes and lithium metal, ensuring efficient interfacial contact and high room-temperature ionic conductivity. In this study, we present a novel main-chain fluorinated polymer electrolyte, FEOP, synthesized through cationic ring-opening polymerization. FEOP integrates high oxidative resistance of polytetrafluoroethylene with lithium metal compatibility of polyether, achieving an oxidation potential of up to 5.6 V and an anion-involved solvation structure. The exceptional stability enables NCM811 cells to deliver an impressive cycling life of 2000 cycles at 1 C up to 4.5 V. Furthermore, at ultra-high cut-off voltages of 4.7 and 4.9 V, both NCM811 and LNMO cells demonstrate stable cycling over 700 cycles, marking the longest lifespan for polymer-based batteries under these challenging conditions. Moreover, 4.7 V solid-state lithium metal pouch cells incorporating FEOP exhibit an energy density of 405.3 Wh kg −1 and maintain stable cycling over 70 cycles, while successfully passing industry-standard nail penetration tests. Moreover, FEOP demonstrate excellent compatibility with ultra-high-loading electrode (70 mg cm −2 ), achieving an exceptional areal capacity of 16.2 mAh cm −2 . These results provide a solid foundation for designing practical electrolytes that enable next-generation high-energy-density and high-safety solid-state batteries.}, archive = {J_ANGEW}, author = {Jie Zhu and Peiran Bian and Guolin Sun and Jinping Zhang and Genglin Lou and Xingchen Song and Ruiqi Zhao and Jie Liu and Nuo Xu and Aihong Li and Xiangjian Wan and Yanfeng Ma and Chenxi Li and Hongtao Zhang and Yongsheng Chen}, doi = {10.1002/anie.202424685}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424685}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Practical high-voltage lithium metal batteries enabled by the in-situ fabrication of main-chain fluorinated polymer electrolytes}, volume = {64}, year = {2025}, }
• (2025). Identical grain atomic force microscopy elucidates facet-dependent restructuring of copper for CO2 electroreduction. ANGEW, 64(16), e202424530. (www)

  @article{ , abstract = {Studies on the catalyst restructuring during the electrochemical CO 2 reduction reaction (eCO 2 RR) are limited and mostly focused on Cu (001) or (111) single crystals as model systems. A comprehensive overview of the dynamic restructuring of different Cu facets is lacking. Here, we first reveal the facet-dependent restructuring of polycrystalline Cu electrodes through electron backscatter diffraction (EBSD) and identical grain atomic force microscopy (AFM). This combined analysis provides new insights into the evolution of crystal domains (EBSD) and surface topography (AFM) at varying conditions (e.g., applied potential and oxidative-reductive pulses). The statistic slope distribution function was applied to study the restructuring asymmetry on five Cu facets (i.e., planar vs. atom stepped). We find that planar Cu (001) shows a square-shaped morphology after eCO 2 RR with 4-fold asymmetry restructuring behavior, while triangular features dominate on Cu (111), evidenced by surface changes with 3-fold asymmetry. 2-fold restructuring is observed for Cu (114), (212), and (124) with atom steps, resulting in forming elongated structures. Therefore, the surface restructuring is dominated by the asymmetry of its facet lattice structure (i.e., planar vs. atom-stepped). This work underscores the potential of combining techniques to elucidate the relationship between surface restructuring and crystal facets on different length scales.}, archive = {J_ANGEW}, author = {Hui Wang and Laurens D. B. Mandemaker and Jim de Ruiter and Xiang Yu and Ward van der Stam and Bert M. Weckhuysen}, doi = {10.1002/anie.202424530}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424530}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identical grain atomic force microscopy elucidates facet-dependent restructuring of copper for CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Creation of dopant-plasmon synergism in double perovskites for bias-free photoelectrochemical synthesis of bromohydrins and hydrogen peroxide. ANGEW, 64(16), e202424395. (www)

  @article{ , abstract = {The integration of photoexcited charge carriers into the synthesis of valuable chemicals offers substantial sustainability benefits, particularly by replacing toxic and costly oxidants and reductants typically used in conventional processes. The efficiency of such transformations is fundamentally governed by the ability to optimize light absorption and charge carrier dynamics within photoelectrodes/photocatalysts. Herein, we present a Cu + /Cu 2+ -substituted double perovskite Cs 2 AgBiBr 6 photoanode, embedded with plasmonic Ag nanoparticles, for bias-free photoelectrochemical production of bromohydrins and H 2 O 2 . Spectroscopic analyses, coupled with three-dimensional finite-difference time-domain simulations, demonstrate that the inclusion of Ag nanoparticles significantly enhances electromagnetic energy utilization and improves carrier separation efficiency. The synergistic effect of the Cu 2+ and Ag nanoparticles results in a 7-fold increase in the yield of 2-bromo-1-phenylethanol, compared to pristine Cs 2 AgBiBr 6 , alongside an impressive H 2 O 2 productivity of 25.8 μmol h −1 cm −2 . Experimental and theoretical investigations reveal that the Cu 2+ substitution strengthens Br − adsorption and oxidation, promoting the bromohydroxylation of alkenes via electrophilic addition in the bulk solution. These findings offer critical insights into the design of advanced metal halide perovskites for sustainable and solar-driven chemical transformations.}, archive = {J_ANGEW}, author = {Linqian Li and Qiang Luo and Yifan Wang and Xueli Zhang and Yating Wen and Ning Wang and Thamraa AlShahrani and Shengqian Ma}, doi = {10.1002/anie.202424395}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424395}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Creation of dopant-plasmon synergism in double perovskites for bias-free photoelectrochemical synthesis of bromohydrins and hydrogen peroxide}, volume = {64}, year = {2025}, }
• (2025). Giant bulk photovoltaic effect in a chiral polar crystal based on helical one-dimensional lead halide perovskites. ANGEW, 64(16), e202424391. (www)

  @article{ , abstract = {Chiral polar crystals composed of one-dimensional (1D) conducting materials exhibit unique physical phenomena. The present study focused on helical 1D-structured lead halide perovskite derivatives with chiral naphthylethylamine as organic cations, ( R or S -NEA)[PbI 3 ]( R -NEA= R -(+)-1-(1-naphthyl)ethylamine, S -NEA= S -(−)-1-(1-naphthyl)ethylamine). A thermally controlled crystallization method has successfully yielded crystals with a polar chiral space group of C 2. The crystals show significantly intense signals of circular dichroism (CD) originating from the asymmetrical electronic transition characteristic of helical 1D structure. In addition, generation of an anomalous zero-bias photocurrent (bulk photovoltaic effect (BPVE)) was observed with an open-circuit voltage up to 15 V, which is five times larger than the band gap. This study suggests that parallel arrangements of the helical semiconducting materials are the promising way to obtain chiral polar crystal exhibiting high performance BPVE.}, archive = {J_ANGEW}, author = {Ayumi Ishii and Ryohei Sone and Tomohide Yamada and Mizuki Noto and Hikari Suzuki and Daiki Nakamura and Kei Murata and Takuya Shiga and Kazuyuki Ishii and Masayuki Nihei}, doi = {10.1002/anie.202424391}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Giant bulk photovoltaic effect in a chiral polar crystal based on helical one-dimensional lead halide perovskites}, volume = {64}, year = {2025}, }
• (2025). Binding-site purification of actives (B-SPA) enables efficient large-scale progression of fragment hits by combining multi-step array synthesis with HT crystallography. ANGEW, 64(16), e202424373. (www)

  @article{ , abstract = {Fragment approaches are long-established in target-based ligand discovery, yet their full transformative potential lies dormant because progressing the initial weakly binding hits to potency remains a formidable challenge. The only credible progression paradigm involves multiple cycles of costly conventional design-make-test-analyse medicinal chemistry. We propose an alternative approach to fragment elaboration, namely performing large numbers of parallel and diverse automated multiple step reactions, and evaluating the binding of the crude reaction products by high-throughput protein X-ray crystallography. We show it is effective and low-cost to perform, in parallel, large numbers of non-uniform multi-step reactions, because, even without compound purification, crystallography provides a high-quality readout of binding. This can detect low-level binding of weakly active compounds, which the target binding site extracts directly from crude reaction mixtures. In this proof-of-concept study, we have expanded a fragment hit, from a crystal-based screen of the second bromodomain of pleckstrin homology domain-interacting protein (PHIP(2)), using array synthesis on low-cost robotics. We were able to implement 6 independent multi-step reaction routes of up to 5 steps, attempting the synthesis of 1876 diverse expansions, designs entirely driven by synthetic tractability. The expected product was present in 1108 (59%) crude reaction mixtures, detected by liquid chromatography mass spectrometry (LCMS). 22 individual products were resolved in the crystal structures of crude reaction mixtures added to crystals, providing an initial structure activity relationship map. 19 of these showed binding pose stability, while, through binding instability in the remaining 3 products, we could resolve a stereochemical preference for mixtures containing racemic compounds. One compound showed biochemical potency (IC 50 =34 μM) and affinity (K d =50 μM) after resynthesis. This approach therefore lends itself to routine fragment progression, if coupled with algorithmically guided compound and reaction design and new formalisms for data analysis.}, archive = {J_ANGEW}, author = {Harold Grosjean and Anthony Aimon and Storm Hassell-Hart and Warren Thompson and Lizbé Koekemoer and James Bennett and Anthony Bradley and Cameron Anderson and Conor Wild and William J. Bradshaw and Edward A. FitzGerald and Tobias Krojer and Oleg Fedorov and Philip C. Biggin and John Spencer and Frank von Delft}, doi = {10.1002/anie.202424373}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424373}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Binding-site purification of actives (B-SPA) enables efficient large-scale progression of fragment hits by combining multi-step array synthesis with HT crystallography}, volume = {64}, year = {2025}, }
• (2025). Atomically dispersed metal catalysts for oxygen reduction reaction: Two-electron vs. four-electron pathways. ANGEW, 64(16), e202424161. (www)

  @article{ , abstract = {Developing eco-friendly electrochemical devices for electrosynthesis, fuel cells (FCs), and metal-air batteries (MABs) requires precisely designing the electronic pathway in the oxygen reduction reaction (ORR) process. Understanding the principle of developing low-cost, highly active, and stable catalysts helps to reduce the usage of noble metals in ORR. Atomically dispersed metal catalysts (ADMCs) emerge as promising alternatives to replace commercial noble metals due to their high utilization of active metal atoms, high intrinsic activity, and controllable coordination environments. In this review, the research tendency and reaction mechanisms in ORR are first summarized. The basic principles concerning the geometric size and chemical coordination of two-electron ORR (2e − ORR) catalysts were then discussed, aiming to outline the evolution of material design from 2e − ORR to four-electron ORR (4e − ORR). Subsequently, recent advances in ADMCs primarily investigated for the 4e − ORR are well-documented. These advances encompass studies on M−N−C coordination, light heteroatom doping, dual-metal atoms-based coordination, and interaction between nanoparticle (NPs)/nanoclusters (NCs) and atomically dispersed metals (ADMs). Finally, the setups for 2/4e − ORR applications, key challenges, and opportunities in the future design of ADMCs for the ORR are highlighted.}, archive = {J_ANGEW}, author = {Ao Yu and Yang Yang}, doi = {10.1002/anie.202424161}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomically dispersed metal catalysts for oxygen reduction reaction: Two-electron vs. four-electron pathways}, volume = {64}, year = {2025}, }
• (2025). [C2N4H7O][NH2SO3]: High-performance ultraviolet nonlinear optical crystal with ditrigon coupled guanylurea group. ANGEW, 64(16), e202424153. (www)

  @article{ , abstract = {The Development of high-performance short-wave ultraviolet (UV) nonlinear optical (NLO) crystals is critical in the field of optoelectronic functional crystals. High-performance NLO functional units are crucial for achieving desired target crystals. In this study, a promising group, guanylurea ([C 2 N 4 H 7 O] + , abbreviated as GU), was investigated using a unit coupling strategy. Furthermore, by modifying the KBe 2 BO 3 F 2 template structure at the molecular level, the first metal-free guanylurea sulfamate [C 2 N 4 H 7 O][NH 2 SO 3 ] was successfully synthesized. This crystal achieved an effective balance between the short UV cutoff edge (227 nm), strong second-harmonic generation (SHG) response (6.2×KDP), and large birefringence (0.225@1064 nm). In addition, the remarkable phase-matching capability provides the potential for a fourth-harmonic generation (266 nm) in the Nd: YAG laser. Theoretical calculations indicated that GU and its favorable arrangement were primarily responsible for the large SHG effect and birefringence. Our study demonstrates that the GU group is promising for the development of UV NLO crystals.}, archive = {J_ANGEW}, author = {Xin Wen and Yuchen Yan and Jingyao Lu and Xuemei Shi and Piao Tang and Jindong Chen and Guangsai Yang and Guang Peng and Haohai Yu and Huaijin Zhang and Zhanggui Hu and Jiyang Wang and Ning Ye}, doi = {10.1002/anie.202424153}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424153}, shortjournal = {Angew. Chem. Int. Edit.}, title = {[C2N4H7O][NH2SO3]: High-performance ultraviolet nonlinear optical crystal with ditrigon coupled guanylurea group}, volume = {64}, year = {2025}, }
• (2025). Transient dangling active sites of Fe(III)−N−C single-atom catalyst for efficient electrochemical CO2 reduction reaction. ANGEW, 64(16), e202424150. (www)

  @article{ , abstract = {The Fe single-atom catalyst (SAC) with an oxidation state of III anchored on the N-doped carbon substrate (Fe(III)−N−C) delivers superior activity for catalyzing the electrochemical CO 2 reduction reaction (eCO 2 RR) to produce CO, but its mechanism remains contentious and the commonly adopted FeN 4 -C model is not a conformant model for Fe(III)−N−C but for Fe(II)−N−C. Herein, employing the grand-canonical ensemble modeling with the density functional theory method benchmarked against the high-level wavefunction theory method, we first identify the conformant model for Fe(III)−N−C to be FeN 1 C 3 -C, and we then unveil that the Fe(III)N 1 C 3 -C SAC generates a novel type of dangling active site transiently under working conditions, in which the Fe single-atom leaves from the anchoring site by breaking all the Fe−C bonds but retains a stable binding to the substrate by the Fe−N bond. Thus, we further elucidate that this flexible dangling active site of Fe(III)−N−C renders a convoluted reaction network with facile CO 2 activation, which delivers superior activity for eCO 2 RR. Our findings provide a novel understanding of the structure–activity relationship for Fe−N−C and concrete insights into the design of highly active SACs.}, archive = {J_ANGEW}, author = {Yun-Ze Qiu and Xiao-Meng Liu and Wenying Li and Jun Li and Hai Xiao}, doi = {10.1002/anie.202424150}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424150}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transient dangling active sites of Fe(III)−N−C single-atom catalyst for efficient electrochemical CO2 reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Hydrogenation of organic molecules via direct mechanocatalysis. ANGEW, 64(16), e202424139. (www)

  @article{ , abstract = {Mechanochemical hydrogenation of unsaturated C−C and C−O, as well as N−O and C−X bonds is successfully achieved without the use of solvents, ligands, or catalyst powders via ball milling. A variety of catalysts are electroplated onto the walls of the milling vessel, allowing for simple recycling and reuse of the catalytic material. Hydrogen gas is directly introduced into the milling vessel, eliminating the need for hydrogen donor compounds which contribute to waste production and suboptimal atom economy. This approach enables the quantitative hydrogenation of unsaturated carbon-carbon bonds, achieving near-complete conversion within just 20 minutes at ambient temperature and pressures as low as 1.5 bar. Carbonyls, nitro groups, and organohalides were converted within reaction times of up to 12 hours. Mechanistic investigations suggest the reaction to be following established mechanisms for hydrogenation. Finally, chemoselective hydrogenation of various reducible functional groups was explored, demonstrating the versatility and efficiency of this solvent-free mechanochemical approach with simple catalyst recycling for hydrogenation reactions.}, archive = {J_ANGEW}, author = {Maike Mayer and Maximilian Wohlgemuth and Anastasia Salomé Straub and Sven Grätz and Lars Borchardt}, doi = {10.1002/anie.202424139}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424139}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogenation of organic molecules via direct mechanocatalysis}, volume = {64}, year = {2025}, }
• (2025). Boosting Li−CO2 battery performance via high-entropy alloy catalysts: Insights into configurational entropy effect. ANGEW, 64(16), e202424121. (www)

  @article{ , abstract = {Li−CO 2 batteries have attracted considerable attention for their ability to combine CO 2 fixation and conversion with high-density energy storage. However, sluggish kinetics of CO 2 reduction and evolution reactions at cathodes lead to large overpotentials and poor cyclic stability. To address this issue, it is critical to develop advanced cathode catalysts. High-entropy alloys (HEAs), a new class of catalysts, have exhibited exceptional catalytic activities in various electrochemical reactions. Nevertheless, the intrinsic relationship between mix configurational entropy (▵S mix ) and catalytic properties of HEAs remains unclear. Herein, we prepared a series of quinary FeCoNiCuRu alloys with different ▵S mix values supported on carbon nanofibers as cathode catalysts in Li−CO 2 batteries. Experimental and computational results reveal a positive correlation between ▵S mix and catalytic activity, attributed to charge redistribution among elements with different electronegativities. The Li−CO 2 battery using the alloy catalyst with the maximum ▵S mix value delivers the largest capacity of 6160 mAh g −1 , the lowest charge potential plateau below 4.0 V, and remarkable cycling stability (550 cycles/5500 h), surpassing most reported Ru-based catalysts. Furthermore, fabrication of pouch cells with low noble metal loading demonstrates the practical potential of HEAs for Li−CO 2 batteries. This work provides insights into high-entropy engineering for advanced electrocatalysts in Li−CO 2 batteries.}, archive = {J_ANGEW}, author = {Zhang Wen and Xiaowei Mu and Xinyi Sun and Zhenming Xu and Mingbo Zheng and Haoshen Zhou and Ping He}, doi = {10.1002/anie.202424121}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424121}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting Li−CO2 battery performance via high-entropy alloy catalysts: Insights into configurational entropy effect}, volume = {64}, year = {2025}, }
• (2025). Electrolyte design using “Porous water” for high-purity carbon monoxide electrosynthesis from dilute carbon dioxide. ANGEW, 64(16), e202424104. (www)

  @article{ , abstract = {Electrosynthesis of high-purity carbon monoxide (CO) from captured carbon dioxide (CO 2 ) remains energy-intensive due to the unavoidable CO 2 regeneration and post-purification stages. Here, we propose a direct high-purity CO electrosynthesis strategy employing an innovative electrolyte, termed porous electrolyte (PE), based on “porous water”. Zeolite nanocrystals within PE provide permanent pores in the liquid phase, enabling physical CO 2 adsorption through an intraparticle diffusion model, as demonstrated by molecular dynamics simulations and in situ spectral analysis. Captured CO 2 spontaneously desorbs under applied reductive potential, driven by the interfacial CO 2 concentration gradient, and is subsequently reduced electrochemically. The high CO 2 concentration in PE enhances mass transfer, and surface ion exchange between Si−OH groups and K + ions on the zeolite surface generates a stronger interfacial electric field, promoting electron transfer steps. This optimized kinetics for mass and electron transfer confers heightened intrinsic activity toward CO 2 electroreduction. The PE-based electrolysis system demonstrated superior CO Faradaic efficiency and partial current density compared to the conventional CO 2 -fed system. A circular system using PE and a Ni−N/C cathode realized continuous production of high-purity CO (97.0 wt %) from dilute CO 2 (15 %) and maintained >90.0 wt % under 150 mA cm −2 , with significantly reduced energy consumption and costs.}, archive = {J_ANGEW}, author = {Wei Zhang and Minyang Dai and Zhouliangzi Zeng and Yahan Wang and Yan Zhang and Wenpeng Ni and Shuangyin Wang and Shiguo Zhang}, doi = {10.1002/anie.202424104}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte design using “Porous water” for high-purity carbon monoxide electrosynthesis from dilute carbon dioxide}, volume = {64}, year = {2025}, }
• (2025). Highly precise prediction of micro- and supra-pKa based on 3D descriptors integrating non-covalent interactions. ANGEW, 64(16), e202424069. (www)

  @article{ , abstract = {Accurate p K a prediction is crucial for understanding proton dissociation in complex molecular systems. However, existing models often face challenges in addressing subtle stereoelectronic effects and conformational flexibility. This study presents H-SPOC, a localized 3D descriptor that captures covalent and non-covalent interactions and incorporates solvent effects to predict site-specific p K a values accurately. H-SPOC was validated on multiple benchmark datasets, including SAMPL6, SAMPL7, and SAMPL8, where it outperformed state-of-the-art methods. H-SPOC also proved versatile across various applications, including 2-acetoxybenzoic acid (the main components of aspirin) non-equilibrium conformations, glycine‘s microstate distributions, and the stereoelectronic anomalies of Janus Sponge and Meldrum's Acid. It addressed challenging supra-p K a predictions in crystalline environments and accurately correlated p K a with reaction rates, selectivity, tautomerism, and pharmacokinetic properties. With its chemically intuitive design and computational efficiency, H-SPOC provides an efficient framework for rapid and precise micro- and supra-p K a predictions, offering significant potential in drug discovery, catalysis, and materials science.}, archive = {J_ANGEW}, author = {Siyuan Liu and Qi Yang and Long Zhang and Sanzhong Luo}, doi = {10.1002/anie.202424069}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly precise prediction of micro- and supra-pKa based on 3D descriptors integrating non-covalent interactions}, volume = {64}, year = {2025}, }
• (2025). Localized alkaline microenvironments enhanced upon tip effects for efficient antibacterial applications. ANGEW, 64(16), e202424067. (www)

  @article{ , abstract = {The electrochemical disinfection mechanism primarily relies on a high-voltage pulsed electric field and electrocatalytic generation of highly oxidative radicals but suffers from shortcomings of either high voltages (dozens of kV) or significant gas supply. This study proposes an in situ electrocatalytic sterilization strategy that forms localized alkaline microenvironments in neutral electrolytes under a constant current of −12 mA at a relatively lower voltage (−0.5 V vs. RHE). The nanowire cathode surface can effectively adsorb hydronium ions (H 3 O + ) from the solution during H 2 evolution, leading to a rapid increase in hydroxide ions (OH − ) concentration in the surrounding solution. This leads to a high diffusion zone of OH − , creating a localized alkaline microenvironment. Scanning electrochemical microscopy (SECM) and finite element analysis (FEA) reveal that the nanowire-derived tip-enhanced effect significantly enhances OH − accumulation around the cathode, effectively inactivating Escherichia coli ( E. coli ) at 10 7 CFU/mL within 3 minutes at −0.5 V. The resulting increase in OH − concentration drives rapid sterilization by inhibiting bacterial ATP synthesis and inducing oxidative stress. This method can efficiently inactivate microorganisms in a short time, while having minimal impact on the overall pH of the environment, making it a safe and environmentally friendly approach.}, archive = {J_ANGEW}, author = {Junrong Chen and Hao Liu and Yanjing Wang and Shang Wang and Yang-Yu Liu and Zhujun Fu and Hao Shi and Tong Sun and Yuanhong Xu}, doi = {10.1002/anie.202424067}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202424067}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Localized alkaline microenvironments enhanced upon tip effects for efficient antibacterial applications}, volume = {64}, year = {2025}, }
• (2025). The interplay between component denticity and flexibility promotes the formation of [AgI⋅⋅⋅AgI]-stabilised links and knots. ANGEW, 64(16), e202423962. (www)

  @article{ , abstract = {A subtle interplay between the flexibility of the 2,2’-bipyridyl-based diamine and the denticity of the coordination domain formed upon self-assembly enabled the formation of four distinct topologies stabilised by [Ag⋅⋅⋅Ag] 2+ pairs. The reactions utilising 2,6-diformylpyridine resulted in the formation of silver(I)-stabilised molecular tweezer, trefoil knot, and Solomon link. The 1,8-naphthyridine-based dialdehyde promoted the formation of [2]catenanes and trefoil knot, demonstrating very close Ag I ⋅⋅⋅Ag I distances. Two of the studied assemblies demonstrated interesting luminescent properties in the solid state.}, archive = {J_ANGEW}, author = {Aleksandra Sarwa and Andrei Khmara and Krzysztof A. Konieczny and Dagmara Kulesza and Eugeniusz Zych and Bartosz Trzaskowski and Bartosz Szyszko}, doi = {10.1002/anie.202423962}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423962}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The interplay between component denticity and flexibility promotes the formation of [AgI⋅⋅⋅AgI]-stabilised links and knots}, volume = {64}, year = {2025}, }
• (2025). Tailoring sodium carboxymethylcellulose binders for high-voltage LiCoO2 via thermal pulse sintering. ANGEW, 64(16), e202423796. (www)

  @article{ , abstract = {Polyvinylidene fluoride (PVDF), as the commercial cathode binder for lithium-ion batteries, presents several practical challenges, including insufficient conductivity, weak adhesion to active materials, and the use of toxic N-methylpyrrolidone for slurry preparation. However, while most water-soluble binders can address the aforementioned issues, they fail to meet the requirements of high-voltage cathodes. In this work, we innovatively employed a thermal pulse sintering strategy to modify carboxymethyl cellulose sodium (CMC), enabling their application in 4.6 V LiCoO 2 (93 % capacity retention after 200 cycles). This strategy facilitates the decomposition of electrochemically active carboxyl groups, leading to ring opening reactions that generate numerous ether linkages (-C−O−C-) without introducing undesirable side effects on LiCoO 2 . The resulting components form additional charge carrier (i.e., Li + and e − ) pathways on the cathode surface. Additionally, the heating process also promotes uniform coating of the binder on the surface of LiCoO 2 , creating a protective layer that inhibits interfacial side reactions. Through proposing a scalable and economic manufacturing technology of multifunctional binder, this work enlightens the avenues for practical high-energy-density batteries.}, archive = {J_ANGEW}, author = {Shiming Chen and Hengyao Zhu and Jiangxiao Li and Zu-Wei Yin and Taowen Chen and Xiangming Yao and Wenguang Zhao and Haoyu Xue and Xin Jiang and Yongsheng Li and Hengyu Ren and Jun Chen and Jun-Tao Li and Luyi Yang and Feng Pan}, doi = {10.1002/anie.202423796}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423796}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring sodium carboxymethylcellulose binders for high-voltage LiCoO2 via thermal pulse sintering}, volume = {64}, year = {2025}, }
• (2025). Integrating circular polarized luminescence and long persistent luminescence in cu8 cage-like clusters via ligand engineering. ANGEW, 64(16), e202423787. (www)

  @article{ , abstract = {Copper clusters with diverse luminescent properties are of particular interest. In this study, a series of Cu 8 clusters with cage-like structures was synthesized and characterized. By employing a stepwise ligand engineering strategy that progressively introduced circularly polarized luminescence (CPL) and long persistent luminescence (LPL) properties, we successfully synthesized R / S- Cu 8 −Cl , the first copper cluster to demonstrate both CPL and LPL. The CPL originates from the chiral metal core induced by the chiral alkynyl ligand, whereas the LPL is attributed to the inherent properties of chlorine-modified triphenylphosphine, which is retained and modified after ligation. The polymethyl methacrylate (PMMA) film containing Cu 8 clusters displays lifetimes of up to 75.18 ms at room temperature and an afterglow exceeding 1.5 s, marking the longest luminescent lifetime recorded for molecular copper-cluster-based materials known to date. Additionally, R / S- Cu 8 −Cl shows excitation-dependent luminescence and variations in luminescence when UV light is switched on and off, highlighting its potential for advanced anti-counterfeiting applications. This work not only presents innovative cage-like copper cluster structures but also offers new approaches for designing multifunctional clusters.}, archive = {J_ANGEW}, author = {Hao Zheng and Yan Li and Wen-Wen Zhan and Jie Zhou and Guanyi Wu and Chengkai Zhang and Di Sun and Yang Yang}, doi = {10.1002/anie.202423787}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423787}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating circular polarized luminescence and long persistent luminescence in cu8 cage-like clusters via ligand engineering}, volume = {64}, year = {2025}, }
• (2025). Intrinsic distortion against jahn-teller distortion: A new paradigm for high-stability na-ion layered mn-rich oxide cathodes. ANGEW, 64(16), e202423728. (www)

  @article{ , abstract = {Layered manganese-rich oxides (LMROs) are widely recognized as the leading cathode candidates for grid-scale sodium-ion batteries (SIBs) owing to their high specific capacities and cost benefits, but the notorious Jahn-Teller (J-T) distortion of Mn 3+ always induces severe structural degradation and consequent rapid cathode failure, impeding the practical implementation of such materials. Herein, we unveil the “intrinsic distortion against J-T distortion” mechanism to effectively stabilize the layered frameworks of LMRO cathodes. The intrinsic distortion simply constructed by introducing bulk oxygen vacancies is systematically confirmed by advanced synchrotron X-ray techniques, atomic-scale imaging characterizations, and theoretical computations, which can counteract the J-T distortion during cycling due to their opposite deformation orientations. This greatly decreases and uniformizes the lattice strain within the ab plane and along the c axis of the material, thereby alleviating the P2-P′2 phase transition as well as suppressing the edge dislocation and intragranular crack formation upon repeated cycles. As a result, the tailored P2-Na 0.72 Mg 0.1 Mn 0.9 O 2 cathode featuring intrinsic distortion delivers a considerably enhanced cycling durability (91.9 % capacity retention after 500 cycles) without sacrificing the Mn 3+ /Mn 4+ redox capacity (186.5 mAh g −1 at 0.3 C). This intrinsic distortion engineering paves a brand-new and prospective avenue toward achieving high-performance LMRO cathodes for SIBs.}, archive = {J_ANGEW}, author = {Junteng Jin and Yao Wang and Xudong Zhao and Yang Hu and Tianyu Li and Hui Liu and Yi Zhong and Lifang Jiao and Yongchang Liu and Jun Chen}, doi = {10.1002/anie.202423728}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423728}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intrinsic distortion against jahn-teller distortion: A new paradigm for high-stability na-ion layered mn-rich oxide cathodes}, volume = {64}, year = {2025}, }
• (2025). Helically chiral mixed-valence systems comprising N-heterotriangulenes: Stabilization of the cationic species by π-expansion. ANGEW, 64(16), e202423516. (www)

  @article{ , abstract = {We report the efficient stabilization of nitrogen-centered radical cations in a dimeric N -heterotriangulene bridged by a rigid π-conjugated [5]helicene backbone ( NTH ). The rigid scaffold exhibits helical chirality, allowing the enantiomers to be separated and their chiroptical properties studied, including circular dichroism (CD) and circularly polarized luminescence (CPL). Successive oxidation towards the radical cation NTH ⋅ + and dication NTH 2+ reveals strong electronic communication between the two nitrogen-centers, as demonstrated by X-ray crystallography, electrochemistry, UV/Vis/nIR spectroscopy and electron paramagnetic resonance (EPR) spectroscopy. CD measurements of the enantiomerically pure cations reveal strong Cotton effects in the nIR region extending up to 2000 nm. Density functional theory confirms the observed enhanced electronic communication, classifying NTH ⋅ + as a Robin-Day Class III mixed-valence charge-transfer (MV–CT) system. NTH 2+ exhibits a quinoidal structure with partial diradical character and open-shell singlet ground state, as shown by variable temperature EPR measurements. Time-resolved transient absorption spectroscopy shows the photo-induced generation of NTH ⋅ + in the presence of a suitable electron acceptor.}, archive = {J_ANGEW}, author = {Jan Borstelmann and Simon Zank and Marcel Krug and Georg Berger and Nina Fröhlich and Gabriel Glotz and Frederik Gnannt and Lars Schneider and Frank Rominger and Felix Deschler and Timothy Clark and Georg Gescheidt and Dirk M. Guldi and Milan Kivala}, doi = {10.1002/anie.202423516}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Helically chiral mixed-valence systems comprising N-heterotriangulenes: Stabilization of the cationic species by π-expansion}, volume = {64}, year = {2025}, }
• (2025). Quasi-solid fiber-shaped lithium-ion batteries with fire resistance. ANGEW, 64(16), e202423419. (www)

  @article{ , abstract = {Flexible batteries such as scalable fiber-shaped lithium-ion batteries (FLIBs) hold great potential for powering wearable electronics due to their excellent electrochemical performance, flexibility, and weavability. However, the use of organic liquid electrolytes raises serious safety concerns, including leakage and combustion hazards. In this study, we develop fire-resistant lithium cobalt oxide/graphite FLIBs by employing an in situ polymerized gel polymer electrolyte (GPE) incorporating 1,3,3,5,5-pentafluoro-1-ethoxy-cyclotriphosphazene (PFPN) as a flame retardant and triethylene glycol dimethacrylate (TEGDMA) as a crosslinker. This in situ polymerization of GPE is well-suited for continuous FLIB production and enhances the electrolyte/electrode interface. The resulting GPE eliminates the inherent flammability of liquid electrolytes with zero self-extinguishing time, attributed to a dual flame-retardant mechanism: gas-phase free radical scavenging and condensed-phase carbon formation. Notably, the FLIBs using the flame-retardant GPEs demonstrate no thermal runaway and maintain nonflammability under various abusive conditions, including mechanical abuse (cutting or collision), electrical abuse (overcharging or overdischarging), and thermal abuse (overheating or fire hazards). Additionally, these FLIBs achieve excellent cycling stability over 500 cycles, and retain 99.4 % of capacity after 10,000 bending cycles, highlighting their outstanding durability. This work presents an effective and straightforward approach to greatly enhance the safety and practicality of FLIBs for wearable applications.}, archive = {J_ANGEW}, author = {Xiangran Cheng and Chenhao Lu and Xiaocheng Gong and Chuanfa Li and Jifeng Wang and Jiahe Qu and Yunting Zhang and Tianbing Song and Yanan Zhang and Haibo Jiang and Chuang Wang and Yao Long and Yuanhong Cao and Ying Wang and Wei Li and Huisheng Peng and Bingjie Wang}, doi = {10.1002/anie.202423419}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423419}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quasi-solid fiber-shaped lithium-ion batteries with fire resistance}, volume = {64}, year = {2025}, }
• (2025). Achieving room-temperature phosphorescence in solution phase from carbon dots confined in nanocrystals. ANGEW, 64(16), e202423388. (www)

  @article{ , abstract = {Carbon dots (CDs) have attracted growing interest in the construction of room-temperature phosphorescent (RTP) materials. However, in the solution phase of CDs, it is still challenging to obtain efficient and stable phosphorescent emission due to the intense quenching effect by dissolved oxygen and solvent molecules. Herein, we report robust phosphorescence in the solution phase, achieved by encapsulating citrate-derived CDs into NaYF 4 nanocrystals via a one-step method of high-temperature coprecipitation. Combined characterizations show that the triplet emission from CDs is related to the abundance of C=O in the CDs, the formation of ionic-bond networks around the CDs, and the spatial confinement and quenching inhibition effects of NaYF 4 nanocrystals. Notably, the transition of CDs@NaYF 4 from hydrophobicity to hydrophilicity can be easily achieved by simple surface modulation of NaYF 4 nanocrystals, which allows the RTP of CDs to be maintained in either polar or nonpolar solvents. In addition, CDs@NaYF 4 exhibits stable afterglow in different pH environments, suggesting its excellent stability. Finally, we demonstrated the application of CDs@NaYF 4 in 3D printing, oily anti-counterfeiting patterns, and cell imaging. Our work can serve the controllable preparation of solution-phase RTP materials and their various applications.}, archive = {J_ANGEW}, author = {Xiaoyan He and Weilan Huang and Yihao Zheng and Xiaokai Xu and Haopeng Wei and Ping Liang and Xianfeng Yang and Chaofan Hu and Xuejie Zhang and Bingfu Lei and Xingcai Zhang and Jianting Ye and Yingliang Liu and Jianle Zhuang}, doi = {10.1002/anie.202423388}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423388}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving room-temperature phosphorescence in solution phase from carbon dots confined in nanocrystals}, volume = {64}, year = {2025}, }
• (2025). Single-step synthesis of dimethyl ether from syngas over nanoparticle-derived bifunctional Pd/CeO2/Al2O3 catalysts. ANGEW, 64(16), e202423273. (www)

  @article{ , abstract = {The single-step syngas-to-dimethyl ether (STD) process offers both economic and technical advantages over the current two-step industrial process that utilizes Cu/ZnO/Al 2 O 3 catalysts. Here, we report a highly active bifunctional Pd/CeO 2 /γ-Al 2 O 3 catalyst, in which Pd colloids dispersed in a nanoscale CeO 2 matrix serve as the key building block for the methanol-active component, efficiently catalysing the STD reaction. For Pd/CeO 2 /γ-Al 2 O 3 with a high Pd-CeO 2 interface concentration, CO conversion and dimethyl ether yield are significantly increased compared to Pd supported on Al 2 O 3 . Systematic investigations using spectroscopic and microscopic techniques reveal the formation of highly dispersed palladium clusters/particles confined within the nanoparticulate CeO 2 matrix. The superior catalytic performance in both activity and stability observed for the Pd/CeO 2 /γ-Al 2 O 3 in the STD reaction stems from the active cationic palladium interfacial species and the presence of adjacent O vacancies.}, archive = {J_ANGEW}, author = {Bing Wang and Zairan Yu and Shuang Chen and Nicola Da Roit and Dieter Schild and Michael Zimmermann and Yuemin Wang and Silke Behrens}, doi = {10.1002/anie.202423273}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423273}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-step synthesis of dimethyl ether from syngas over nanoparticle-derived bifunctional Pd/CeO2/Al2O3 catalysts}, volume = {64}, year = {2025}, }
• (2025). Three-dimensional Metal–Organic frameworks with selectively activated aromatic rings for high-capacity and high-rate lithium-ion storage. ANGEW, 64(16), e202423186. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) are considered promising candidates for anode materials in Li-ion batteries (LIBs) owing to their designable structure, abundant active sites, and well-organized porosity. However, the structural factors governing active site utilization and Li-ion storage kinetics remain inadequately understood. In particular, the Li-ion storage behaviors of aromatic rings with high LUMO energy levels and situated in varying chemical environments remain a highly debated issue. Herein, a new cobalt-based MOF (Co-NTTA, NTTA ligand: 5,5′,5′′-((4,4′,4′′-nitrilotris (benzoyl)) tris-(azanediyl)) triisophthalic acid), featuring aromatic rings situated in diverse local environments, is deliberately designed and synthesized. Experimental characterizations and first-principles calculations have verified the occurrence of a reversible electrochemical reaction involving a total of 51 electrons among the NTTA ligands, cobalt cations, and Li + ions. Unlike the traditional concept of superlithiation, the three inner aromatic rings are selectively activated by π-aromatic conjugation networks and π π stacking, contributing to a reversible 6-electron pseudocapacitive Li + intercalation reaction. Conversely, the three outer aromatic rings remain inert toward Li + ions. Impressively, the Co-NTTA MOF anode, with selectively activated aromatic rings, delivers a reversible capacity of up to 956 mAh g −1 at 200 mA g −1 and demonstrates exceptional high-rate durability, further supporting a 4.3 V lithium-ion hybrid electrochemical capacitor with high energy/power density.}, archive = {J_ANGEW}, author = {Sha Li and Jiande Lin and Huiqun Wang and Shiyuan Zhou and Xiangyang Guo and Xiao Zhan and Hongwei Tao and Haitao Hu and Zhengyou He and Honggang Liao and Dongping Zhan and Li Zhang}, doi = {10.1002/anie.202423186}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three-dimensional Metal–Organic frameworks with selectively activated aromatic rings for high-capacity and high-rate lithium-ion storage}, volume = {64}, year = {2025}, }
• (2025). High-density catalytic sites grafting on 2D-metal oxides for acceptorless alcohol dehydrogenation. ANGEW, 64(16), e202423169. (www)

  @article{ , abstract = {Installing well-defined high density single-atomic catalyst (SAC) sites is highly desired for the synergistic cooperative effect in efficient chemical synthesis but elusive to synthesize due to unavoidable atomic segregation into clusters or particulates. We implemented a 2D-nanoconfined SAC grafting strategy. Inside a bilayer silica envelope, single metal hydroxide layer, pre-loaded with the catalytic metal (Pt, Pd, Ir) precursors, underwent controlled thermal conversion to the homogeneously embedded SACs decorated onto the in situ generated 1 nm-thin transition metal oxide (TMO) nanosheet. Ultranarrow confined slit-space exclusively availed laterally emerging cation vacancies of TMO host, as atomic scale sockets to capture SACs within 2D-plane while vertically restricting the atomic aggregation into nanoparticulates. High density SACs stably decorated on isolated TMO nanosheet, could be obtained in a controllable manner. Well-defined SACs on TMO were conveniently employed for acceptorless dehydrogenation of a variety of alcohols with quite high activities outperforming reported catalysts. In-depth, mechanistic investigation revealed the dramatic enhancement in acceptorless dehydrogenation reaction rates by following distinct reaction pathways (concerted or stepwise) depending on the density of SACs cooperativity effect. Such advantageous effect is distinct from the reactions on isolated metal sites in low-density SACs or nanoparticle surface.}, archive = {J_ANGEW}, author = {Yu-Rim Hong and Nitee Kumari and Junwon Kim and Ankur Maji and Min Gyu Kim and Kyu-Min Jo and Si-Young Choi and Ji Hoon Shim and In Su Lee}, doi = {10.1002/anie.202423169}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-density catalytic sites grafting on 2D-metal oxides for acceptorless alcohol dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Urea complete conversion to compound fertilizer in industrial-scale tandem reactors. ANGEW, 64(16), e202423092. (www)

  @article{ , abstract = {A compound fertilizer with NH 4 H 2 PO 4 and KH 2 PO 4 offer significant advantages in enhancing both crop yield and quality. Ammonia (NH 3 ) is essential for the synthesis of the compound fertilizer, which was produced by an energy intensive chemical process. Developing efficient and environmental friendly methods to produce ammonia-containing compound fertilizers is crucial and extremely challenging. Here, we present a tandem catalysis system capable of achieving complete conversion of abundant urea into compound fertilizer in industrial-scale reactors by combining electrochemical and subsequent chemical processes. In a typical cycle, with the use of 200 g urea, 1580 g of solid compound fertilizer (KH 2 PO 4 and NH 4 H 2 PO 4 ) and 232 L of pure H 2 are produced without any further separation process. The key to the realization of this system is to precisely control the rate of urea consumption and NO 2 − formation in electrochemical process. By maintaining a precise molar concentration ratio of urea to NO 2 − at 1/2 in electrolyte, urea can completely react with NO 2 − to form N 2 , while CNO − can be converted into NH 4 + to form compound fertilizer in the second step of H 3 PO 4 treatment, achieving complete conversion of urea without by-products formation. This method remarkably reduces H 2 production potential while allowing for extraction of ammonia from urea-containing wastewater or urine to create pure compound fertilizer at an anticipated lower price than that of current market.}, archive = {J_ANGEW}, author = {Jun Hu and Shan-Qing Li and Xintong Gao and Fei Zhang and Zhi-Xiang Yuan and Tong Wu and Qing-Feng Jin and Ping Chen and Yao Zheng and Shi-Zhang Qiao}, doi = {10.1002/anie.202423092}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202423092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Urea complete conversion to compound fertilizer in industrial-scale tandem reactors}, volume = {64}, year = {2025}, }
• (2025). A metastable oxygen redox cathode for lithium-ion batteries. ANGEW, 64(16), e202422789. (www)

  @article{ , abstract = {Simultaneously harnessing cation and anion redox activities in the cathode is crucial for the development of high energy-density lithium-ion batteries. However, achieving long-term stability for both mechanisms remains a significant challenge due to pronounced anisotropic volume changes at low lithium content, unfavorable cation migration, and oxygen loss. Here, we demonstrate exceptionally stable cation and anion redox behavior in a metastable, cobalt-free layered oxide, Li 0.693 [Li 0.153 Ni 0.190 Mn 0.657 ]O 2 (LLNMO). After 50 cycles at 50 mA/g (~0.2 C), the cathode retains 97.4 % of its initial capacity (222.4 mAh/g) with negligible voltage decay. This remarkable stability is attributed to its metastable O6-type structure (R-3m symmetry) with unique local geometry. The face-sharing connectivity between lithium layers and alternating transition metal (TM) layers effectively suppresses TM migration-induced voltage decay during anion redox. Additionally, the structure balances interlayer cation/cation and anion/anion repulsions, resulting in minimal expansion and contraction during de-/lithiation (<2.3 % along the c -axis) and excellent structural reversibility. These findings highlight that layered oxides with a metastable framework are promising cathode candidates for next-generation ultra-high-energy lithium-ion batteries.}, archive = {J_ANGEW}, author = {Yanfang Wang and Cheng Li and Yingzhi Li and Raquel de Benito and Jacob Williams and Joshua M. Stratford and Zhiqiang Li and Chun Zeng and Ning Qin and Hongzhi Wang and Yulin Cao and Dominic Gardner and Wilgner Lima da Silva and Sahil Tippireddy and Qingmeng Gan and Fangchang Zhang and Wen Luo and Joshua W. Makepeace and Ke-Jin Zhou and Kaili Zhang and Fucai Zhang and Phoebe K. Allan and Zhouguang Lu}, doi = {10.1002/anie.202422789}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202422789}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A metastable oxygen redox cathode for lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Mitigating diffusion-induced intragranular cracking in single-crystal LiNi0.5Mn1.5O4 via extended solid-solution behavior. ANGEW, 64(16), e202422726. (www)

  @article{ , abstract = {Single-crystal cathodes have been investigated for their inherent resistance to intergranular cracking due to the absence of grain boundaries. However, these materials exhibit significant intragranular cracking, and the underlying mechanisms remain unclear. In this study, we examined the impact of extended solid-solution reactions on mitigating crack formation in magnesium-doped single-crystal LiNi 0.5 Mn 1.5 O 4 (Mg-SC-LNMO) cathodes. With Mg acting as a structural pillar, the overall volume change was reduced by nearly 50 %, the two-phase reaction was effectively suppressed, and the Li-ion diffusion coefficient was doubled. Continuum modeling based on experimental observations demonstrates that Mg doping significantly reduces the internal stress induced by lithium diffusion, thereby preserving the mechanical integrity of single-crystal LNMO. This improvement leads to enhanced electrochemical performance and durability. Our study provides new insights into mechanically robust single-crystal cathodes and proposes a design strategy to improve the durability of next-generation Li-ion batteries.}, archive = {J_ANGEW}, author = {Hyeonsol Shin and Agwu Ndukwe and Taemin Kim and Ji Hoon Lee and Guanchen Li and Hyeon Jeong Lee}, doi = {10.1002/anie.202422726}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202422726}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mitigating diffusion-induced intragranular cracking in single-crystal LiNi0.5Mn1.5O4 via extended solid-solution behavior}, volume = {64}, year = {2025}, }
• (2025). Conformal reconstruction and dual-vacancy engineering breaks kinetics limitations for energetic aqueous dual-cation storage. ANGEW, 64(16), e202422403. (www)

  @article{ , abstract = {Efficient aqueous energy storage with non-metallic ions is highly desired but challenged by achieving kinetically favorable surface/interface storage chemistry. Herein, by refining the surface proton environment, layered double hydroxides (LDHs) with hydrogen-aluminum dual vacancies and 3D diffusion channels are demonstrated upon conformal surface reconstruction. An energetic NH 4 + /H + dual-ion co-intercalation chemistry is enabled, leading to a remarkable gravimetric specific capacity of up to 604 mAh g −1 and long-cycle stability. Combining in-situ Raman spectroscopy and in-situ electrochemical quartz crystal microbalance (EQCM) techniques, we reveal and visualize the conformal reconstruction process and the reversible dual-cation storage mechanism. Density functional theory (DFT) calculation shows that the dual-vacancy coupling helps the dissolution of inert Al from LDHs for enriching active sites. At the same time, the residual Al shows the pining effect on the [MnO 6 ] octahedron to restrain the Jahn–Teller distortion. The manganese sites adjacent to Al vacancies promote the adsorption of NH 4 + /H + and the H vacancies facilitate the adsorption of NH 4 + , responsible for an optimal dual-cation storage chemistry. This work demonstrates how the dual vacancies emerge to modulate the carrier migration and thereby the capacity, providing a viable solution of surface/interface optimization for efficient aqueous energy storage.}, archive = {J_ANGEW}, author = {Chenxi Li and Wei Guo and Jinxin Wang and Wanbin Dang and Qiuyu Zhang}, doi = {10.1002/anie.202422403}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202422403}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformal reconstruction and dual-vacancy engineering breaks kinetics limitations for energetic aqueous dual-cation storage}, volume = {64}, year = {2025}, }
• (2025). An authentic Al=Si double bond. ANGEW, 64(16), e202422007. (www)

  @article{ , abstract = {Aluminatasilenes are the elusive heavier counterparts of the well-known borataalkenes in which the B=C double bond is formally replaced by an Al=Si moiety. We report the isolation of a four-membered anionic AlSi 3 cycle with a bona fide Al=Si double bond, which is obtained by the reaction of 2 eq. of disilenide Tip 2 Si=SiTipLi with H 2 AlCl (Tip=2,4,6-triisopropylphenyl). X-ray crystallography, UV/Vis spectroscopy and computational analysis confirm the double bond character with a very short Al−Si bond of 2.283(1) Å and high Wiberg bond index (WBI) of 1.31. Intramolecular C−H activation by the Al=Si bond and the reactions with sulfur sources confirm typical double bond reactivity.}, archive = {J_ANGEW}, author = {Nasrina Parvin and Ankur and Bernd Morgenstern and David Scheschkewitz}, doi = {10.1002/anie.202422007}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202422007}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An authentic Al=Si double bond}, volume = {64}, year = {2025}, }
• (2025). Intrinsically photothermal-driven and reconfigurable liquid crystal elastomer actuators enabled by multifunctional dynamic covalent organic photothermal molecules. ANGEW, 64(16), e202421915. (www)

  @article{ , abstract = {Intrinsically photothermal-responsive soft actuators possessing reconfigurability have attracted great attention due to their ability to change their actuation mode to satisfy diverse practical applications. However, challenges remain in designing and fabricating organic photothermal molecules featuring polymerizable or cross-linkable groups, especially those with multifunctional properties. Here, a novel class of versatile light-driven reconfigurable liquid crystal elastomer (LCE) materials, denoted as PUOLCE, has been developed. The multifunctional dynamic covalent organic photothermal molecules, serving as chain extenders, photothermal agents, and dynamic covalent bond precursors, are chemically bonded into LCEs, thereby endowing the LCEs with photothermal-responsiveness and dynamic properties. The intrinsic photothermal effect of PUOLCE allows the exchange reaction of dynamic oxime-carbamate bonds to undergo rapid welding under near-infrared (NIR) light. Leveraging the NIR-assisted welding strategy, the PUOLCE-based building units are capable of assembling into various complex actuators with new deformation modes. Besides, the assembled actuators can be easily reconfigured to perform different mechanical tasks (e.g., flower blooming, grasping objects, and elevating objects) under NIR illumination. Furthermore, the PUOLCE actuators can be controlled globally or locally for light-driven locomotion by controlling the area exposed to the NIR irradiation. This work provides insights into the development of adaptive soft actuators with tunable shape-morphing capabilities.}, archive = {J_ANGEW}, author = {Yangyang Zhu and Jiaxiang Huang and Hao Mi and Zhentian Xu and Yun Ai and Sihui Gong and Chunquan Li and Meng Wang and Lie Chen}, doi = {10.1002/anie.202421915}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202421915}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intrinsically photothermal-driven and reconfigurable liquid crystal elastomer actuators enabled by multifunctional dynamic covalent organic photothermal molecules}, volume = {64}, year = {2025}, }
• (2025). Ligand-enabled nondirected and regioselective arylation of internal alkenes with simple arenes. ANGEW, 64(16), e202420443. (www)

  @article{ , abstract = {Regioselective functionalization of internal alkenes has become a highly efficient approach for preparing stereochemically defined multi-substituted olefins. Unlike traditional methods that require directing groups, activating groups, or active chemical bonds (e.g., halide, pseudo halide, organometallic reagent, etc.), there remains a strong demand for nondirected and selective functionalization of unactivated alkenes with simple coupling partners, both in academic research or industrial applications. Herein, we report the development of a pyridone-oxazoline ( Pyoox ) type ligand that combines the features of both pyridone and pyridine-oxazoline in assisting Pd-catalyzed olefination. This ligand enables the activation of simple (hetero) arenes and internal alkenes within a single reaction system. A nondirected and regioselective arylation from simple raw materials has been achieved, providing a straightforward route to various trisubstituted olefins in moderate to excellent yields, with excellent regio-/stereocontrol. Experimental and computational studies on mechanisms offer insight into the distinctive properties and performance of this ligand-promoted catalysis. The synthetic utility of this method is further demonstrated by the simplified synthesis and late-stage diversification of bioactive molecules.}, archive = {J_ANGEW}, author = {Tianming Liu and Xi Deng and Yue Gao and Haofan Li and Yu Du and Weiping Su}, doi = {10.1002/anie.202420443}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202420443}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-enabled nondirected and regioselective arylation of internal alkenes with simple arenes}, volume = {64}, year = {2025}, }
• (2025). Cyclometalated Iridium(III) schiff base complexes for chemiluminogenic bioprobes. ANGEW, 64(16), e202419856. (www)

  @article{ , abstract = {Chemiluminogenic bioimaging has emerged as a promising paradigm due to its independence from light excitation, thereby circumventing challenges related to light penetration depth and background autofluorescence. However, the availability of effective chemiluminophores remains limited, which substantially impedes their bio-applications. Herein, we discovered for the first time that cyclometalated iridium(III) Schiff base complexes can unexpectedly generate chemiluminescence. Notably, the chemiluminescence reaction was rapid, with a half-life of only 0.86 s, significantly faster than previously reported examples. Unlike conventional chemiluminescent scaffolds, the distinguishing feature of the chemiluminogenic iridium(III) complex is its unique intramolecular imine-to-amide conversion upon reaction with reactive oxygen species (ROS). Intriguingly, the chemiluminogenicity of these complexes is not influenced by the cyclometalating ligands but is closely associated with the Schiff base ligand, allowing for tuning of the emission colors via altering the cyclometalating ligands. Additionally, we formulated one of the Schiff base complexes ( 1 ) as water-soluble chemiluminogenic nanoparticles (CLNPs) and successfully employed them as activatable chemiluminescence bioprobes for precise and rapid imaging of hypochlorite-related biological events both in vitro and in vivo . We believe that this significant finding of the development of chemiluminogenic Schiff base complexes will greatly facilitate the designing of innovative chemiluminophores for theranostic applications.}, archive = {J_ANGEW}, author = {Jing-Hui Zhu and Xin He and Yingnan Wu and Haiqiao Huang and Dekai Yang and Jianyuan Li and Mingrui Gu and Lei Wang and Mingle Li and Xiaoqiang Chen and Xiaojun Peng}, doi = {10.1002/anie.202419856}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {16}, pages = {e202419856}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyclometalated Iridium(III) schiff base complexes for chemiluminogenic bioprobes}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: An amorphous donor-acceptor conjugated polymer with both high charge carrier mobility and luminescence quantum efficiency. ANGEW, 64(15), e202581562. (www)

  @article{ , archive = {J_ANGEW}, author = {Mingcong Wang and Guangjie Xia and Chen Yang and Lu Zhang and Mark Nikolka and Weimin Zhang and Camila Cendra and Wanli Liu and Shunan Zhao and Jinfeng Zeng and Cao Zou and Julien Gorenflot and Alberto Salleo and Frédéric Laquai and Henning Sirringhaus and Iain McCulloch and Hu Chen}, doi = {10.1002/anie.202581562}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202581562}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: An amorphous donor-acceptor conjugated polymer with both high charge carrier mobility and luminescence quantum efficiency}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Liquid metal nanobiohybrids for high-performance solar-driven methanogenesis via multi-interface engineering. ANGEW, 64(15), e202581561. (www)

  @article{ , archive = {J_ANGEW}, author = {Wenzhi Gu and Jing Hu and Lei Li and Mingqiu Hong and Dong Zhang and Jiajing Chen and Jie Ye and Shungui Zhou}, doi = {10.1002/anie.202581561}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202581561}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Liquid metal nanobiohybrids for high-performance solar-driven methanogenesis via multi-interface engineering}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: Low temperature atomic layer deposition of (00l)-oriented elemental bismuth (Angew. chem. int. ed. 15/2025). ANGEW, 64(15), e202506105. (www)

  @article{ , archive = {J_ANGEW}, author = {Jorge Luis Vazquez Arce and Alessio Amoroso and Nicolas Perez and Jaroslav Charvot and Dominik Naglav Hansen and Panpan Zhao and Jun Yang and Sebastian Lehmann and Angelika Wrzesińska Lashkova and Fabian Pieck and Ralf Tonner Zech and Filip Bureš and Annalisa Acquesta and Yana Vaynzof and Anjana Devi and Kornelius Nielsch and Amin Bahrami}, doi = {10.1002/anie.202506105}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202506105}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: Low temperature atomic layer deposition of (00l)-oriented elemental bismuth (Angew. chem. int. ed. 15/2025)}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: DNA framework-ensembled aptamers enhance fluid stability in circulating tumor cells capture for tumor treatment evaluation (Angew. chem. int. ed. 15/2025). ANGEW, 64(15), e202506102. (www)

  @article{ , archive = {J_ANGEW}, author = {Yirong Chen and Fan Li and Shuyang Zhang and Feng Liu and Chenzhou Mao and Min Li and Jinhua Jiang and Yueyue Zhang and Chunhai Fan and Xiaolei Zuo}, doi = {10.1002/anie.202506102}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202506102}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: DNA framework-ensembled aptamers enhance fluid stability in circulating tumor cells capture for tumor treatment evaluation (Angew. chem. int. ed. 15/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Tandem catalysis for plastic depolymerization: In situ hydrogen generation via methanol APR for sustainable PE hydrogenolysis (Angew. chem. int. ed. 15/2025). ANGEW, 64(15), e202506095. (www)

  @article{ , archive = {J_ANGEW}, author = {Junsung Lee and Taeeun Kwon and Ki Hyuk Kang and Wangyun Won and Insoo Ro}, doi = {10.1002/anie.202506095}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202506095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Tandem catalysis for plastic depolymerization: In situ hydrogen generation via methanol APR for sustainable PE hydrogenolysis (Angew. chem. int. ed. 15/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: High-performance overall water splitting dominated by direct ligand-to-cluster photoexcitation in Metal−Organic frameworks (Angew. chem. int. ed. 15/2025). ANGEW, 64(15), e202505566. (www)

  @article{ , archive = {J_ANGEW}, author = {Qia-Chun Lin and Wei-Ming Liao and Jiayu Li and Bowei Ye and Da-Tang Chen and Xiao-Xiang Zhou and Peng-Hui Li and Meng Li and Ming-De Li and Jun He}, doi = {10.1002/anie.202505566}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202505566}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: High-performance overall water splitting dominated by direct ligand-to-cluster photoexcitation in Metal−Organic frameworks (Angew. chem. int. ed. 15/2025)}, volume = {64}, year = {2025}, }
• (2025). Jeffrey lipshultz. ANGEW, 64(15), e202504527. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202504527}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202504527}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Jeffrey lipshultz}, volume = {64}, year = {2025}, }
• (2025). Innovative asymmetric CoSA-N-Ti3C2Tx catalysis: Unleashing superoxide radicals for rapid self-coupling removal of phenolic pollutant. ANGEW, 64(15), e202502307. (www)

  @article{ , abstract = {The polymerization pathway of contaminants rivals the traditional mineralization pathway in water purification technologies. However, designing suitable oxidative environments to steer contaminants toward polymerization remains challenging. This study introduces a nitrogen-oxygen double coordination strategy to create an asymmetrical microenvironment for Co atoms on Ti 3 C 2 T x MXenes, resulting in a novel Co-N 2 O 3 microcellular structure that efficiently activates peroxymonosulfate. This unique activation capability led to the complete removal of various phenolic pollutants within 3 min, outperforming the representative Co single-atom catalysts reported in the past three years. Identifying and recognizing reactive oxygen species highlight the crucial role of ⋅O 2 − . The efficient pollutant removal occurs through a ⋅O 2 − -mediated radical pathway, functioning as a self-coupling reaction rather than deep oxidation. Theoretical calculations demonstrate that the electron-rich pollutants transfer more electrons to the catalyst surface, inducing the reduction of dissolved oxygen to ⋅O 2 − in the Co-N 2 O 3 microregion. In a practical continuous flow-through application, the system achieved 100 % acetaminophen removal efficiency in 6.5 h, with a hydraulic retention time of just 0.98 s. This study provides new insights into the previously underappreciated role of ⋅O 2 − in pollutant purification, offering a simple strategy for advancing aggregation removal technology in the field of wastewater treatment.}, archive = {J_ANGEW}, author = {Miao Li and Zhiyan Feng and Xingzhong Yuan and Chenxu Guo and Chencheng Qin and Zihan Shu and Zhiyan Guo and Edison Huixiang Ang and Wenwei Li and Yan Wu and Hou Wang}, doi = {10.1002/anie.202502307}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202502307}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Innovative asymmetric CoSA-N-Ti3C2Tx catalysis: Unleashing superoxide radicals for rapid self-coupling removal of phenolic pollutant}, volume = {64}, year = {2025}, }
• (2025). Ligand-engineered hydrophilic perovskite enabling surface potential-driven anions exchange for multicolor biosensing. ANGEW, 64(15), e202501312. (www)

  @article{ , abstract = {The difficulty in designing zwitterionic ligands impedes the water-dispersed CsPbX 3 perovskite nanocrystals (NCs) and their application as fast anion exchange (FAE) probes in biosensing. This study proposes a design paradigm for zwitterionic ligands predicated upon revealing the mechanism of the S N 2 reaction between unsaturated alkylamines (Cn′) and haloalkanoic acids (HAAs). Among them, the C=C bond can enhance the nucleophilicity of Cn′ and promote the electrostatic adsorption of HAAs onto Cn′, i.e., the geometric preorganization process, thereby initiating the S N 2 reaction. Moreover, an appropriate “bridge” length enables HAAs to balance the geometric preorganization process and the Sigma hole intensity of the C−Br bond. Zwitterionic ligands derived from oleylamine (C18′) and 5-bromovaleric acid (5-BVA) endow CsPbBr 3 NCs with water dispersibility, an almost 100 % photoluminescence quantum yield, and enhanced surface potential, facilitating the capture of halide ions and driving the FAE reaction. Using AgI nanoparticles (NPs) as latent anion exchangers, a third FAE strategy is presented for multicolor biosensing. Such a robust biosensing strategy can generate wavelength shift and chromatic difference for biological target molecules, exemplified by H 2 S, and is ultimately applicable to multicolor assay in biological, environmental and food samples, demonstrating the immense potential of perovskite-based FAE probes in biosensing.}, archive = {J_ANGEW}, author = {Shuo Wang and Yi Liu and Gaoqiong Deng and Wanjun Long and Hengye Chen and Yuxiu Xiao and Yuanbin She and Haiyan Fu}, doi = {10.1002/anie.202501312}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202501312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-engineered hydrophilic perovskite enabling surface potential-driven anions exchange for multicolor biosensing}, volume = {64}, year = {2025}, }
• (2025). Oligomerized electron acceptors with alkynyl linkages to suppress electron-phonon coupling for low-energy-loss organic solar cells. ANGEW, 64(15), e202501302. (www)

  @article{ , abstract = {A novel series of alkynyl-linked oligomerized electron acceptors have been synthesized via Sonogashira coupling. The alkynyl linkages can enhance molecular planarity and aggregation, suppress electron-phonon coupling, and reduce non-radiative losses. Binary organic solar cells (OSCs) achieved an efficiency of 17.90%, with a non-radiative loss of 0.185 eV, while ternary OSCs reached a remarkable efficiency of 19.52%. Oligomerized electron acceptors, featuring molecular weights akin to polymers and well-defined chemical structures, have emerged as promising candidates for organic solar cells (OSCs) due to their consistent batch-to-batch reproducibility and improved thermal stability. In this study, we developed a series of oligomerized electron acceptors incorporating alkynyl linkages via an efficient Sonogashira coupling reaction between alkyne-substituted Y-type precursors and multi-substituted iodobenzenes. This method produced monomeric (S-Alkyne-YF), dimeric (D-Alkyne-YF), and trimeric (T-Alkyne-YF) configurations, enabling systematic control over molecular size and substituent arms. The alkynyl linkages, characterized by high bond strength and planar geometry, enhanced molecular planarity and aggregation in films, thus facilitating precise control over morphology and phase separation in the photoactive layers. Notably, the inclusion of these linkages effectively suppressed electron-phonon coupling, resulting in reduced non-radiative energy losses and elevated photocarrier lifetime. OSCs based on PM6:T-Alkyne-YF achieved a power conversion efficiency of 17.90%, a low non-radiative energy loss of 0.185 eV, and an open-circuit voltage of 0.943 V. Furthermore, integrating T-Alkyne-YF into the D18:N3 blend yielded an exceptional PCE of 19.52%. These results underscore the potential of alkynyl-linked oligomerized acceptors in advancing highly efficient and stable OSCs, offering a viable pathway for reducing electron-phonon coupling and enhancing device performance.}, archive = {J_ANGEW}, author = {Fan Yang and Haisheng Fang and Erqin Guo and Chengyi Xiao and Ziheng Lu and Yuwen Wang and Haiyun Fan and Andong Zhang and Wenbin Lai and Weiwei Li}, doi = {10.1002/anie.202501302}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202501302}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oligomerized electron acceptors with alkynyl linkages to suppress electron-phonon coupling for low-energy-loss organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Realizing a 3 c fast-charging practical sodium pouch cell. ANGEW, 64(15), e202501208. (www)

  @article{ , abstract = {Sodium-ion batteries (SIBs), endowed with relatively small Stokes radius and low desolvation energy of Na + , are reckoned as a promising candidate for fast-charging endeavors. However, the C-rate charging capability of practical energy-dense sodium-ion pouch cells is currently limited to ≤1 C, due to the high propensity for detrimental metallic Na plating on the hard carbon (HC) anode at elevated rates. Here, an ampere-hour-level sodium-ion pouch cell capable of 3 C charging is successfully developed via phosphorus (P)-sulfur (S) interphase chemistry. By rational electrolyte regulation, desired P−S constituents, namely, Na 3 PO 4 and Na 2 SO 4 , are generated in the solid-electrolyte interphase with favorable Na + interface kinetics. Specifically, Na + desolvation energy barrier has been greatly lowered by the weak ion-solvent coordination near the inner Helmholtz plane on Na 3 PO 4 interphase, while Na 2 SO 4 expedites charge carrier mobility due to its intrinsically high ionic conductivity. Consequently, an energy-dense (126 Wh kg −1 ) O3-Na(Ni 1/3 Fe 1/3 Mn 1/3 )O 2 ||HC pouch cell capable of 3 C charging (100 % state of charge) without Na plating can be achieved, with a great capacity retention of 91.5 % over 200 cycles. Further, the assembled power-type Na 3 V 2 (PO 4 ) 3 ||HC pouch cell displays an impressive fast-charging capability of 50 C, which surpasses that of previously reported high-power SIBs. This work serves as an enlightenment for developing fast-charging SIBs.}, archive = {J_ANGEW}, author = {Jinhui Zhao and Hao Lan and Guangze Yang and Qiaonan Zhu and Shuai Dong and Li Jiang and Gongkai Wang and Wenshuo Wei and Liqiang Wu and Bin Zhou and Daojun Yang and Jiangchun Chen and Jie Yang and Mirtemir Kurbanov and Hua Wang}, doi = {10.1002/anie.202501208}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202501208}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Realizing a 3 c fast-charging practical sodium pouch cell}, volume = {64}, year = {2025}, }
• (2025). A bis-perylene diimide macrocycle chiroptical switch. ANGEW, 64(15), e202501122. (www)

  @article{ , abstract = {Helical assemblies of organic dyes are ubiquitous chiral organic materials, with valuable properties including chiroptical switching due to the dynamic nature of supramolecular chirality. Herein, we report a novel chiral bis-perylene diimide macrocycle, which acts as a discrete molecular model for a chiral supramolecular assembly. Point chirality is installed through amino acid-derived imide groups which, upon macrocyclization, is translated into helical chirality in the perylene diimide dimer. In solution, the macrocycle's chiroptical properties are switchable, with both the sign (+/−) and amplitude (on/off) of the signal tuned using solvent and molecular recognition stimuli respectively. The chiral structure–property relationships identified from this macrocycle are important for the design of high fidelity supramolecular chiroptical switches.}, archive = {J_ANGEW}, author = {Denis Hartmann and Samuel E. Penty and Martijn A. Zwijnenburg and Robert Pal and Timothy A. Barendt}, doi = {10.1002/anie.202501122}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202501122}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bis-perylene diimide macrocycle chiroptical switch}, volume = {64}, year = {2025}, }
• (2025). Synergizing interfacial electric field regulation and in situ robust interphases for stable lithium metal batteries at high currents. ANGEW, 64(15), e202501005. (www)

  @article{ , abstract = {Efficient cycling of lithium (Li) metal batteries (LMBs) under extremely high current conditions is critical for their practical applications. Here, we report a novel additive containing fluorine, nitrogen, and iodine elements (designated as FCS) to stabilize Li metal anodes in glyme-based ether electrolytes under high current conditions. Experimental results and molecular dynamics (MD) simulations demonstrate that the cation of FCS selectively adsorbs on the electrode surface, optimizing the inner Helmholtz plane (IHP) structure and effectively regulating the surface electric field, thereby promoting homogeneous Li deposition. Simultaneously, the preferential decomposition of the FCS produces a mechanically robust and ionically conductive solid electrolyte interphase (SEI) comprising LiF, Li 3 N, and LiI components. Consequently, with the FCS additive, Li||Cu cells demonstrate a remarkably average Coulombic efficiency (CE) of 98.12 % at an extremely high current of 20 mA cm −2 over 400 cycles. Additionally, Li||SPAN cells maintain a reversible capacity of 1126 mAh g −1 at 0.5 A g −1 after 200 cycles. This work presents a new approach to simultaneously tune the Helmholtz plane and SEI using trace amounts of additive, paving the way for stable and efficient LMBs under high-current conditions.}, archive = {J_ANGEW}, author = {Weixiang Xie and Junxiong Wu and Xiaoyan Li and Zhengguang Song and Lijuan Tong and Yuhui Miao and Manxian Li and Xuan Li and Manxi Wang and Yue Chen and Xiaochuan Chen and Yuming Chen}, doi = {10.1002/anie.202501005}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202501005}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergizing interfacial electric field regulation and in situ robust interphases for stable lithium metal batteries at high currents}, volume = {64}, year = {2025}, }
• (2025). Photoexcited transition-metal catalyzed carbon-halogen bond formation. ANGEW, 64(15), e202500929. (www)

  @article{ , abstract = {Transition-metal catalysis has proven useful in facilitating carbon-halogen (C−X) bond formation. Despite the vast number of methodologies reported to furnish these bonds, limitations have remained, warranting continued development. The recent surge of metallaphotoredox-based transformations has provided a novel gateway to bypass these limitations. Through the use of photoexcited species, the formation of C−X bonds arise through new mechanistic pathways, finding alternatives to high reaction temperatures and stoichiometric additives. The discovery of this novel strategy has provided access to molecular space that has not been previously attainable. Herein, we report the recent advances on transition-metal photocatalyzed C−X bond formation, in hopes of easing the synthetic endeavours for chemists in industrial and academic laboratories.}, archive = {J_ANGEW}, author = {Ramon Arora and Philip Samokhin and Mark Lautens}, doi = {10.1002/anie.202500929}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500929}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoexcited transition-metal catalyzed carbon-halogen bond formation}, volume = {64}, year = {2025}, }
• (2025). Photoelectrocatalyzed alkylation of phosphonites by direct decarboxylative c(sp3)-P coupling. ANGEW, 64(15), e202500744. (www)

  @article{ , abstract = {A photoelectrocatalytic method is presented that achieves direct decarboxylative C(sp 3 )-P coupling, providing a modular route to alkylphosphinates and alkylphosphonates from readily available carboxylic acids. The success of this reaction hinges on the synergistic combination of electrochemical anodic oxidation and photocatalytic ligand to metal charge transfer (LMCT) decarboxylation. By employing P(III) reagents as limiting reagents, our approach enables efficient alkyl modification of medicinally important nucleosides and complex molecules derived phosphonites, which were challenging to access by existing methods. Detailed mechanistic studies elucidate the critical roles of Fe catalysts and additives, offering valuable insights into the reaction pathway and laying the foundation for future advancements in photoelectrocatalytic C(sp 3 )-heteroatom bond-forming reactions.}, archive = {J_ANGEW}, author = {Kang-Ning Yuan and Tian Xie and Jia-Bao Wang and Dali Wang and Ming Shang}, doi = {10.1002/anie.202500744}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoelectrocatalyzed alkylation of phosphonites by direct decarboxylative c(sp3)-P coupling}, volume = {64}, year = {2025}, }
• (2025). Single-crystal-to-single-crystal synthesis of a polymer in two distinct topologies. ANGEW, 64(15), e202500646. (www)

  @article{ , abstract = {A squaramide-based monomer, designed for topochemical azide-alkyne cycloaddition (TAAC) polymerization, crystallizes as two polymorphs, M1 and M2 , both having crystal packing suitable for topochemical polymerization. The hydrogen-bonding between squaramide units bias the molecular organization in both the polymorphs. 3D packing of H-bonded stacks of monomer lead to juxtaposition of azide and alkyne units of adjacent molecules in a transition-state-like arrangement for their regiospecific cycloaddition reaction. The monomers are arranged as supramolecular sheets and supramolecular helices in polymorph M1 and M2 respectively. Both the polymorphs undergo slow and spontaneous regiospecific TAAC polymerization at room temperature, but react quickly at higher temperatures, resulting in 1,4-traizolyl-linked polymer, with distinct mechanical responses. Upon heating, single crystals of polymorph M1 show expansion followed by contraction without any permanent dimensional change, whereas crystals of polymorph M2 undergo splitting. At moderate temperatures, both the polymorphs undergo single-crystal-to-single-crystal (SCSC) polymerization, resulting in two polymer-polymorphs with distinct topologies that can be studied at atomic resolution by single-crystal X-ray crystallography. The polymorph M1 reacts to polymer P1 with β-sheet-like topology, and polymorph M2 reacts to polymer P2 having polymer chains of helical conformation. Nanoindentation experiments with crystals of these polymers revealed their distinct mechanical properties.}, archive = {J_ANGEW}, author = {Javed R. Pathan and Haripriya Balan and Kaustav Das and C. Malla Reddy and Kana M. Sureshan}, doi = {10.1002/anie.202500646}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500646}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-crystal-to-single-crystal synthesis of a polymer in two distinct topologies}, volume = {64}, year = {2025}, }
• (2025). Towards solid-state batteries using a calcium hydridoborate electrolyte. ANGEW, 64(15), e202500613. (www)

  @article{ , abstract = {Solid-state batteries created from abundant elements, such as calcium, may pave the way for cheaper and safer electrical energy storage. Here we report a new type of solid calcium hydridoborate electrolyte, Ca(BH 4 ) 2 ⋅ 2NH 2 CH 3 , with a high ionic conductivity of σ(Ca 2+ ) ~10 −5 S cm −1 at T =70 °C, which is assigned to a relatively open and flexible structure with apolar moieties and weak dihydrogen bonds that facilitate migration of Ca 2+ ions in the solid state. The compound display a low electronic conductivity, providing an ionic transport number close to unity ( t ion =0.9916). Calcium plating is observed for a Ca|Ca(BH 4 ) 2 ⋅ 2NH 2 CH 3 |Pt electrochemical cell and the electrodes are investigated using scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDS) that reveal a rugged Ca anode surface owing to the stripping process and the presence of Ca-containing domains on the Pt working electrode from the plating process. Improved electrochemical reversiblity was achieved in a three-electrode cell configuration using a Ca x Sn counter and reference electrode and a Sn working electrode, Ca x Sn | Ca(BH 4 ) 2 ⋅ 2NH 2 CH 3 | Sn, providing reversible Ca plating and stripping.}, archive = {J_ANGEW}, author = {Lasse N. Skov and Jakob B. Grinderslev and Therese S. S. Kjær and Lasse R. Kristensen and Torben R. Jensen}, doi = {10.1002/anie.202500613}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500613}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards solid-state batteries using a calcium hydridoborate electrolyte}, volume = {64}, year = {2025}, }
• (2025). A strategy of enhancing polarization to achieve excellent energy storage performance in simple Bi0.5K0.5TiO3-based relaxors. ANGEW, 64(15), e202500516. (www)

  @article{ , abstract = {Dielectric energy storage capacitors are indispensable components in advanced electronic and electrical systems. Excellent performance requires the dielectric materials possessing low residual polarization ( P r ), high breakdown strength ( E b ), and large maximum polarization ( P m ). The first two parameters can be typically achieved through chemical regulation, while the P max is closely related to the matrix. Theoretical calculations demonstrate that a strong coupling of A -O bonds and a large lattice can enhance polarization, thus identifying the prototype Bi 0.5 K 0.5 TiO 3 as a favorable matrix. Here, ultrahigh energy density of 16.5 J/cm 3 and high efficiency of 88.2 % are achieved in 0.76Bi 0.5 K 0.5 TiO 3 -0.24Ca 0.5 Sr 0.5 HfO 3 binary system. This system exhibits the highest comprehensive performance among all reported Bi 0.5 K 0.5 TiO 3 -based ceramics. The large perovskite framework facilitated by the large ionic radius of K + enhances the local polarity of Bi−O and Ca−O, resulting in a large P m of 57.4 μC/cm 2 under an ultrahigh E b of 82 kV/mm. The highly disordered local polar clusters at the nanoscale lead to negligible P r and high η . This work not only provides a unique design concept to enhance the comprehensive energy storage performance from the perspective of local structure, but also offers insight into the origin of high performance.}, archive = {J_ANGEW}, author = {Weiwei Cao and Tianyi Sun and Huajie Luo and Tianyu Li and Kaina Wang and Kai Li and Xingcheng Wang and Chenjie Lou and Na Wang and Bing Xie and Ji Zhang and Matthew G Tucker and Mingxue Tang and Hui Liu and Jun Chen}, doi = {10.1002/anie.202500516}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A strategy of enhancing polarization to achieve excellent energy storage performance in simple Bi0.5K0.5TiO3-based relaxors}, volume = {64}, year = {2025}, }
• (2025). Rigidly locked pyrene excimers in planar chiral pyrenophanes for intense and stable circularly polarized photoluminescence and electrochemiluminescence. ANGEW, 64(15), e202500472. (www)

  @article{ , abstract = {Aiming at the construction of novel platforms with excellent performances in both circularly polarized photoluminescence (CP-PL) and electrochemiluminescence (CP-ECL), a new family of pyrenophanes with rigidly locked pyrene dimers and varied bridges has been designed and synthesized. Attributed to densely packed pyrene excimers, the resultant pyrenophanes revealed tunable bridge-dependent emission behaviors, as investigated by femtosecond time-resolved transient absorption spectroscopy. More importantly, all these planar chiral pyrenophanes display strong CP-PL with large dissymmetry factor ( g PL ) values up to 0.034, and such excellent performances remain stable in a wide range of solvents, temperatures, and concentrations. Attractively, the highest g ECL values up to 0.014 reported so far has been achieved for the CP-ECL emissions of the chiral pyrenophanes. Attributed to their unique structural features and outstanding CPL performances, these novel pyrenophanes could serve as promising platforms for both fundamental investigations on pyrene excimers and practical applications such as chiral sensing.}, archive = {J_ANGEW}, author = {Lin-Tao Bao and Rui-Hua Zhang and Xiaoyue Yuan and Xueli Wang and Peicong Wu and Xu-Qing Wang and Jinquan Chen and Anwei Zhu and Hai-Bo Yang and Wei Wang}, doi = {10.1002/anie.202500472}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rigidly locked pyrene excimers in planar chiral pyrenophanes for intense and stable circularly polarized photoluminescence and electrochemiluminescence}, volume = {64}, year = {2025}, }
• (2025). Molecular engineering of amino acid crystals with enhanced piezoelectric performance for biodegradable sensors. ANGEW, 64(15), e202500334. (www)

  @article{ , abstract = {Amino acid crystals have emerged as promising piezoelectric materials for biodegradable and biocompatible sensors; however, their relatively low piezoelectric coefficients constrain practical applications. Here, we introduce a fluoro-substitution strategy to overcome this limitation and enhance the piezoelectric performance of amino acid crystals. Specifically, we substituted hydrogen atoms on the aromatic rings of L-tryptophan, L-phenylalanine, and N-Cbz-L-phenylalanine with fluorine, resulting in significantly elevated piezoelectric coefficients. Density functional theory calculations further indicate that fluorination strengthens polarization by modifying molecular dipole moments. Consequently, these fluoro-substituted crystals achieve piezoelectric coefficients of up to 50.36 pm/V, surpassing those of other organic piezoelectric materials such as polyvinylidene fluoride (PVDF), poly(L-lactic acid) (PLLA), and gelatin. When integrated into flexible, biodegradable force sensors, the fluoro-substituted crystals exhibit a broad sensing range, high sensitivity, and stable in vivo operation over extended periods. This work establishes a versatile route for boosting piezoelectricity in biomaterials, thereby broadening their scope in biomedical applications.}, archive = {J_ANGEW}, author = {Yuanqi Cheng and Tianjian Wang and Haoqi Zhu and Xueli Hu and Jing Mi and Lan Li and Yu Zhang and Jiapeng Yang and Liang Dong and Ying Li and Wenxu Sun and Xiaomei Lu and Wei Wang and Yi Cao and Bin Xue}, doi = {10.1002/anie.202500334}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500334}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular engineering of amino acid crystals with enhanced piezoelectric performance for biodegradable sensors}, volume = {64}, year = {2025}, }
• (2025). Chemically patterning lithiophilic interphase to harmonize spatial electrons and thermal catalysis dynamics for safe lithium metal batteries. ANGEW, 64(15), e202500323. (www)

  @article{ , abstract = {Lithium metal batteries have garnered significant attention as promising energy storage solutions. However, their performance is often compromised by the risks associated with highly active metallic lithium, unrestricted electrode expansion, and excessive dendrites growth. Here we introduce an advanced lithiophilic anode substrate designed by chemically patterning technology for multiple security enhancements. The innovative lithiophilic array harmonizes spatial Li + to prepare compact and reversible electrodes. The composite electrodes feature an enhanced C−F component in the solid-electrolyte interface, which protects the deposited lithium metal from unwanted side reactions, thereby stabilizing electrochemical cycling. Notably, the thermal safety can be revealed through the substrate‘s excellent catalytic ability to convert smoke and toxic gases during extreme thermal runaway. This work demonstrates a novel approach to integrating battery cycling stability with thermal safety, paving the way for more reliable and secure energy storage systems.}, archive = {J_ANGEW}, author = {Yisha Wang and Feng Xu and Edison Huixiang Ang and Liu Yang and Tianyang Cui and Haoteng Sun and Mingtong Zhang and Tianxiang Yang and Hanqi Zhang and Jixin Zhu and Yuan Hu}, doi = {10.1002/anie.202500323}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500323}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemically patterning lithiophilic interphase to harmonize spatial electrons and thermal catalysis dynamics for safe lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). The first kleinman-type second-harmonic generation circular dichroism On/Off switchable ferroelectrics. ANGEW, 64(15), e202500285. (www)

  @article{ , abstract = {Chiral ferroelectrics have recently received considerable interest due to their unique chiroptical properties. They can adopt Kleinman symmetry second-harmonic generation (SHG)-active chiral-polar point groups in the ferroelectric phase while Kleinman symmetry SHG-inactive chiral-nonpolar point groups in the paraelectric phase, providing a great opportunity to realize on/off switching of SHG circular dichroism (SHG-CD) response. However, the SHG-CD effect was rarely explored in chiral ferroelectrics, and the on/off switchable SHG-CD has never been reported. Herein, we report the first crown ether-based chiral ferroelectrics ( R / S -CS)Ca(18-crown-6) (CS=camphor-10-sulfonic acid), which undergo a 422 F 2 type ferroelectric phase transition at around 336 K from Kleinman symmetry SHG-active point group 2 to Kleinman symmetry SHG-inactive point group 422. Notably, they exhibit obvious SHG-CD responses with an anisotropy factor of up to 0.31. More importantly, the SHG-CD response can be switched between SHG-CD active (SHG-CD on) and inactive (SHG-CD off) states during the ferroelectric phase transition, which is unprecedented. To the best of our knowledge, this is the first example of Kleinman-type SHG-CD on/off switchable ferroelectric. Our findings open up a new way to switch SHG-CD response based on chiral ferroelectrics, which would greatly inspire the further exploration of switchable SHG-CD effects in chiral ferroelectrics.}, archive = {J_ANGEW}, author = {Hang Peng and Yan Qin and Xiao-Gang Chen and Xian-Jiang Song and Ren-Gen Xiong and Wei-Qiang Liao}, doi = {10.1002/anie.202500285}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500285}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The first kleinman-type second-harmonic generation circular dichroism On/Off switchable ferroelectrics}, volume = {64}, year = {2025}, }
• (2025). Charge polarization boosting electrochemical urea synthesis by co-reduction of CO2 and nitrite in dilute concentrations with a unity carbon selectivity. ANGEW, 64(15), e202500262. (www)

  @article{ , abstract = {Synthesis of urea through electrocatalytic coupling reaction of CO 2 with nitrite (NO 2 − ) represents a sustainable means to substitute the conventional energy-intensive urea synthetic protocol. The direct conversion of dilute NO 2 − in real wastewaters to urea with high efficiency is still a significant challenge, as C-intermediates tend to go through an extensive reduction achieving mostly C-containing productions due to the lack of N-intermediates, originating from slow diffusion rate of NO 2 − . Herein, we report the charge-polarized Fe δ− -Cu δ+ dual sites in metal/carbon heterojunction material (Cu@Fe−N−C) for co-reduction of CO 2 and dilute NO 2 − solution (100 ppm NO 2 − -N). The electron-rich single Fe atoms dispersed N-doped carbon (Fe−N−C) restrain *CO desorption, and the electron-deficient Cu nanoparticles (Cu) promote the deep reduction of NO 2 − to *NH 2 . As a result, the obtained Cu@Fe−N−C exhibits a high Faradaic efficiency for urea of 50.05 % with a yield of 850.57 mg h −1 g −1 at −0.35 V ( vs . RHE) in a flow cell. Moreover, C urea-selectivity reaches to 100 % and a near-unity selectivity for the value-added urea and NH 3 is realized. The present results provide a valuable reference for the design of new catalysts for efficient synthesis of C−N compounds in dilute NO 2 − solution.}, archive = {J_ANGEW}, author = {Zhihao Feng and Lu-Hua Zhang and Yabo Guo and Jiangyi Guo and Fei Li and Fengshou Yu}, doi = {10.1002/anie.202500262}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Charge polarization boosting electrochemical urea synthesis by co-reduction of CO2 and nitrite in dilute concentrations with a unity carbon selectivity}, volume = {64}, year = {2025}, }
• (2025). Manipulating dynamic light-driven solid-liquid transition and static reversible photochromism by an organic cocrystal strategy. ANGEW, 64(15), e202500238. (www)

  @article{ , abstract = {Developing of molecular crystalline materials with light-induced multiple dynamic deformation in space dimension and photochromism on time scales has attracted much attention for its potential applications in actuators, sensoring and information storage. Nevertheless, organic crystals capable of both photoinduced dynamic effects and static color change are rare, particularly for multi-component cocrystal system. In this study, we first report the construction of charge transfer cocrystal allows their light-induced solid-to-liquid transition and photochromic behaviors to be controlled by trans-stilbene (TSB) as an electron donor and 3,4,5,6-tetrafluorophthalonitrile (TFP) as an electron acceptor. In this case, the dynamic photo-responsive solid-to-liquid phase transition is due to the photoisomerization of TSB under UV light irradiation, while the accumulation of melted droplets during solid-state photochemical process causes mechanical deformation of TSB-TFP cocrystals. The subsequent reversible photochromic behavior is attributed to the emergence of free radicals through a photo-induced electron transfer. Moreover, TSB-TFP microcrystals present typical excitation wavelength dependent emission (EWDE) fluorescence by surfactant-mediated method. This work realizes the dynamic-static photochemical cascade processes in response to UV light irradiation in an organic cocrystal system, providing the effective method for a new type of smart photo-responsive materials.}, archive = {J_ANGEW}, author = {Shuzhen Li and Xueyong Huang and Menghao Xing and Dongpu Zhao and Sitong Li and Xiaoyu Cao}, doi = {10.1002/anie.202500238}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500238}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating dynamic light-driven solid-liquid transition and static reversible photochromism by an organic cocrystal strategy}, volume = {64}, year = {2025}, }
• (2025). Flow electroreductive nickel-catalyzed cyclopropanation of alkenes using gem-dichloroalkanes. ANGEW, 64(15), e202500203. (www)

  @article{ , abstract = {Cyclopropanes are valuable motifs in organic synthesis, widely featured in pharmaceuticals and functional materials. Herein, we report an efficient electrochemical methodology for the cyclopropanation of alkenes, leveraging a nickel-catalyzed process in continuous-flow. The developed protocol demonstrates broad substrate scope, accommodating both electron-rich and electron-poor alkenes with high functional group tolerance. Beyond dichloromethane as a feedstock methylene source, the methodology enables the synthesis of methylated, deuterated, and chloro-substituted cyclopropanes. Mechanistic investigations suggest the electro-generation of a nickel carbene as key intermediate. Notably, the reaction operates under ambient conditions, tolerates air and moisture, and achieves scalability through continuous-flow technology, offering a straightforward route to multi-gram quantities with enhanced throughput.}, archive = {J_ANGEW}, author = {Morgan Regnier and Clara Vega and Dimitris I. Ioannou and Zhenyu Zhang and Timothy Noël}, doi = {10.1002/anie.202500203}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500203}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flow electroreductive nickel-catalyzed cyclopropanation of alkenes using gem-dichloroalkanes}, volume = {64}, year = {2025}, }
• (2025). Integrated two-in-one strategy for efficient neutral hydrogen peroxide electrosynthesis via phosphorous doping in 2D mesoporous carbon carriers. ANGEW, 64(15), e202500177. (www)

  @article{ , abstract = {Herein, we demonstrate a two-in-one strategy for efficient neutral electrosynthesis of H 2 O 2 via two-electron oxygen reduction reaction (2e − ORR), achieved by synergistically fine-modulating both the local microenvironment and electronic structure of indium (In) single atom (SA) sites. Through a series of finite elemental simulations and experimental analysis, we highlight the significant impact of phosphorous (P) doping on an optimized 2D mesoporous carbon carrier, which fosters a favorable microenvironment by improving the mass transfer and O 2 enrichment, subsequently leading to an increased local pH levels. Consequently, an outstanding 2e − ORR performance is observed in neutral electrolytes, achieving over 95 % selectivity for H 2 O 2 across a broad voltage range of 0.1 to 0.5 V vs RHE. In a flow cell, the production rate of H 2 O 2 exceeds 22.54 mol g cat −1 h −1 while maintaining high stability at industrial-level current densities. These results are comparable to, if not better than, those achieved under alkaline conditions. Further analysis, both experimental and theoretical, indicates that the P dopant occupies the second coordination sphere of the In SA, which shows optimized OOH* binding strength for an enhanced 2e − ORR kinetic.}, archive = {J_ANGEW}, author = {Chunhong Qi and Weichao Bao and Jingsan Xu and Yu Li and Fangfang Xu and Minghao Li and Lianjun Wang and Wan Jiang and Pengpeng Qiu and Wei Luo}, doi = {10.1002/anie.202500177}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500177}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated two-in-one strategy for efficient neutral hydrogen peroxide electrosynthesis via phosphorous doping in 2D mesoporous carbon carriers}, volume = {64}, year = {2025}, }
• (2025). Cyano-modified multi-resonance thermally activated delayed fluorescent emitters towards pure-green OLEDs with a CIEy value of 0.74. ANGEW, 64(15), e202500108. (www)

  @article{ , abstract = {The development of pure-green organic emitters with ideal emission peaks and ultra-narrow full-widths at half-maximum (FWHMs) remains a formidable challenge. Herein, we report two new green emitters, CNBN and MCNBN , which achieve extremely narrow FWHMs by synergistic rigid π-extension and cyano-substitution of a sky-blue multi-resonance thermally activated delayed fluorescence (MR-TADF) core. The introduction of cyano groups induces red-shifts in the emission to the green region and dramatically minimizes the FWHMs. In toluene solution, CNBN and MCNBN exhibit narrowband emission with a maximum at 501 nm and 510 nm with ultra-narrow FWHMs of 14 nm/0.066 eV and 15 nm/0.071 eV, respectively. Given the near-unity photoluminescence quantum yields and almost 100 % horizontal dipole orientation, the electroluminescent (EL) devices based on CNBN and MCNBN deliver external quantum efficiencies (EQEs) exceeding 30 % with FWHMs of 16 nm/0.072 eV and 17 nm/0.080 eV, respectively. Notably, the MCNBN -based device achieves pure-green emission with a maximum at 517 nm with Commission Internationale de l’Éclairage coordinates of (0.17, 0.74), closely aligning with the BT.2020 green standard.}, archive = {J_ANGEW}, author = {Zhuixing Xue and Yuxuan Hu and Shengbing Xiao and Jiahui Liu and Jingsheng Miao and Chuluo Yang}, doi = {10.1002/anie.202500108}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500108}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyano-modified multi-resonance thermally activated delayed fluorescent emitters towards pure-green OLEDs with a CIEy value of 0.74}, volume = {64}, year = {2025}, }
• (2025). Forward- and retro-vapofluorochromism of sponge-like macrocycle crystals. ANGEW, 64(15), e202500022. (www)

  @article{ , abstract = {Achieving dynamic multicolor emission through solid-state molecular motion is of significant importance for advancing applications in organic solid-state luminescent materials. Herein, we report macrocycle crystals with unique forward- and retro-vapofluorochromic behavior, which is realized by reversible amine vapor uptake and amine-“squeeze” induced guest release. The forward-vapofluorochromism occurs when aliphatic amines penetrate guest-free macrocycle crystals to form host-guest complex crystals. These fluorescent properties can be reversibly toggled by exposing the amine-loaded crystals to another amine vapor through competitive guest replacement inside the crystals. Notably, retro-vapofluorochromism is achieved by exposing amine-loaded crystals to α-methylbenzylamine (MBA). Mechanistic studies show that MBA molecules do not penetrate the crystals, but rather “squeeze” the crystals to release loaded amines, driving the amine-loaded crystals back to the guest-free phase. The demonstrated forward- and retro-vapofluorochromism has already been successfully integrated into a highly secure five-layer information encryption system.}, archive = {J_ANGEW}, author = {Jingwei Huang and Haohui Feng and Linnan Zhang and Kecheng Jie}, doi = {10.1002/anie.202500022}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202500022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Forward- and retro-vapofluorochromism of sponge-like macrocycle crystals}, volume = {64}, year = {2025}, }
• (2025). Clone-resolved chemical depletion of t cells via cellular proximity chemistry. ANGEW, 64(15), e202425628. (www)

  @article{ , abstract = {T cells play a pivotal role in the development of autoimmune diseases. To mitigate autoimmune inflammation without inducing global immunosuppression, it is crucial to selectively eliminate autoreactive T cell clones while preserving the normal T cell repertoire. In this study, we applied cellular proximity chemistry to develop a T-cell depletion method with clonal precision. Using engineered dendritic cells (DCs) with surface-bound photosensitizers, we generated reactive oxygen species (ROS) at immune synapses, leading to the targeted death of antigen-specific T cells in close proximity. This process induces lipid oxidation in T cell membranes, triggering ferroptosis-like cell death. The method enables the selective elimination of specific T cell clones without affecting others, in which the clonal resolution was demonstrated by TCR sequencing. Finally, we demonstrated the efficacy of this approach in a type 1 diabetes model by selectively depleting the pathogenic 8.3 T cell clone, thereby protecting islet β cells and preserving overall T cell function. This strategy offers a promising avenue for immunosuppressive therapy that targets pathogenic T cells while maintaining overall immune integrity.}, archive = {J_ANGEW}, author = {Yunze Wu and Tao Deng and Lin Song and Wenqi Zhu and Da Zhong and Jinbiao Jiao and Wannan Li and Lingyu Zhong and Tian Tian and Lei Dong and Jie P. Li}, doi = {10.1002/anie.202425628}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425628}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Clone-resolved chemical depletion of t cells via cellular proximity chemistry}, volume = {64}, year = {2025}, }
• (2025). Lewis and brønsted acids synergy in photocatalytic aerobic alcohol oxidations. ANGEW, 64(15), e202425551. (www)

  @article{ , abstract = {Photocatalytic chemical transformations for green organic synthesis has attracted much interest. However, their development is greatly hampered by the lack of sufficient reactive sites on the photocatalyst surface for the adsorption and activation of substrate molecules. Herein, we demonstrate that the introduction of well-defined Lewis and Brønsted acid sites coexisting on the surface of TiO 2 (SO 4 2− /N-TiO 2 ) creates abundant active adsorption sites for photoredox reactions. The electron-deficient Lewis acid sites supply coordinatively unsaturated surface sites to adsorb molecular oxygen, and the Brønsted acid sites are liable to donate protons to form hydrogen bonds with the OH groups of alcohols like benzyl alcohol (BA). These coexistent acid sites result in a strong synergistic effect in photocatalytic aerobic oxidation of BA. For example, the conversion of BA to benzaldehyde was found to be 88.6 %, being much higher than those of pristine TiO 2 (14.7 %), N-doped TiO 2 (N-TiO 2 , 24.6 %), sulfated TiO 2 (SO 4 2− / TiO 2 , 35.4 %), and even their sum. The apparent quantum efficiency (AQE) was determined to be 58.1 % at 365 nm and 12.9 % at 420 nm over SO 4 2− /N-TiO 2 . This strategy to create effective synergistic Lewis and Brønsted acids on the catalyst surfaces enables us to apply it to other semiconducting photocatalytic organic transformations.}, archive = {J_ANGEW}, author = {Dexi Yu and Junhua Zou and Lingdong Zeng and Yidong Hou and Wei Lin and Ling Wu and Masakazu Anpo and Jimmy C. Yu and Jinshui Zhang and Xinchen Wang}, doi = {10.1002/anie.202425551}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425551}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lewis and brønsted acids synergy in photocatalytic aerobic alcohol oxidations}, volume = {64}, year = {2025}, }
• (2025). Insights into the electrolyte hydrolysis and its impacts on the interfacial chemistry of a li+-intercalated anode during high-temperature calendar aging. ANGEW, 64(15), e202425491. (www)

  @article{ , abstract = {Calendar aging occurring during high-temperature storage has long plagued practical realization of long-life, high-safety lithium-ion batteries (LIBs). Generally, the aging process is ascribed to the hydrolysis reaction of fluorine-containing electrolyte salt that generates hydrofluoric acid and chemically corrodes the anode surface. Nevertheless, the underlying mechanism about electrolyte degradation, HF generation and surface corrosion remains concealed for various electrolytes. In this work, we employed in situ liquid time-of-flight secondary ion mass spectroscopy to resolve the chemical evolution during high-temperature calendar aging in the bulk of the electrolyte and at the anode/electrolyte interface. Two conventional salts, LiPF 6 and Li bis(fluorosulfonyl)imide (LiFSI), were employed for comparison. We identify that the high-temperature hydrolysis of LiPF 6 preferentially occurs when the anion aggregates ([PF 6 +LiPF 6 ] − ) are attacked by trace H 2 O. HPO 2 F 2 , HF and LiF are generated and assist formation of an inorganics-rich solid electrolyte interphase (SEI), improving anode stability against parasitic reactions. The LiFSI-based electrolyte does not involve hydrolysis, which facilities the formation of an organics-rich SEI. Nevertheless, the SEI does not passivate the anode surface and could induce severe corrosions via electron tunneling at a high temperature. Our work offers original insights into rational design of electrolyte and interface for high-energy, long-calendar-life LIBs.}, archive = {J_ANGEW}, author = {Yu Zhang and Zhen-Zhen Shen and Yanyan Zhang and Min Niu and Liwei Dong and Wen-Peng Wang and Di-Xin Xu and Ge Li and Ling-Yan Jiang and Fuyi Wang and Rui Wen and Chunhui Yang and Jia-Yan Liang and Sen Xin and Yu-Guo Guo}, doi = {10.1002/anie.202425491}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425491}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insights into the electrolyte hydrolysis and its impacts on the interfacial chemistry of a li+-intercalated anode during high-temperature calendar aging}, volume = {64}, year = {2025}, }
• (2025). Selective interface engineering with large π-conjugated molecules enables durable zn anodes. ANGEW, 64(15), e202425487. (www)

  @article{ , abstract = {Undesirable dendrite growth and side reactions at the electrical double layer (EDL) of Zn/electrolyte interface are critical challenges limiting the performance of aqueous zinc ion batteries. Through density functional theory calculations, we demonstrate that grafting large π-conjugated molecules (e.g. bilirubin, biliverdin, lumirubin, and hemoglobin) onto Zn surface induces preferential adsorption on non-(002) facets, leading to interfacial charge redistribution, upshifted Zn d-band center, and enhanced H + fixation capability. Among these, bilirubin (BR) is identified as the most effective, preferentially adsorbing onto non-Zn(002) facets to inhibit hydrogen evolution reaction and promote Zn(002) planar growth during plating. This approach results in average Coulombic efficiency of 99.86 % over 4000 cycles in Zn||BR-1@Cu cells and prolonged lifespan exceeding 1600 h in BR-1@Zn||BR-1@Zn cells at 10 mA cm −2 and 1 mAh cm −2 . Even under harsh conditions of 25 mA cm −2 and 10 mAh cm −2 , BR-1@Zn||BR-1@Zn cell maintains a lifespan of over 400 h. Furthermore, BR-1@Zn||MnO 2 and BR-1@Zn||NVO full cells achieve 76.4 % and 86.1 % capacity retention after 800 and 1400 cycles at 1.0 A g −1 , respectively. This study underscores the importance of grafting large π-conjugated molecules to allow selective Zn(002) exposure, Zn d-band center upshift, and EDL structure regulation, paving the way towards durable Zn anodes.}, archive = {J_ANGEW}, author = {Feng Zhang and Qiangqiang Meng and Jia-Wei Qian and Jingwei Chen and Wei-Xu Dong and Kai Chen and Yang-Feng Cui and Shi Xue Dou and Li-Feng Chen}, doi = {10.1002/anie.202425487}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425487}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective interface engineering with large π-conjugated molecules enables durable zn anodes}, volume = {64}, year = {2025}, }
• (2025). Overcoming boundaries: Towards the ambient aqueous synthesis of covalent organic frameworks. ANGEW, 64(15), e202425426. (www)

  @article{ , abstract = {The synthesis of covalent organic frameworks (COFs) has traditionally been carried out under strict solvothermal and anaerobic conditions. The utilization of organic solvents in such reactions not only carries significant costs but also imposes a great burden on the environment. The fabrication of COFs using alternative synthetic pathways has, therefore, seen rapid development in recent years and much attention has been placed on green and sustainable methods in particular. The synthesis of COFs in purely aqueous media, however, remains challenging due to the delicate nature of the chemical reactions and the crystallization process in water. This mini-review discusses different synthetic strategies for the construction of crystalline COFs in aqueous media and offers a perspective on the future development of facile COF synthesis in ambient conditions.}, archive = {J_ANGEW}, author = {Michelle Åhlén and Xueying Kong and Wei Zhao and Félix Zamora and Chao Xu}, doi = {10.1002/anie.202425426}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Overcoming boundaries: Towards the ambient aqueous synthesis of covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Gradient design with low-tortuosity overcoming kinetic limitations in high-loading solid-state cathodes. ANGEW, 64(15), e202425357. (www)

  @article{ , abstract = {The extensive commercialization of practical solid-state batteries (SSBs) necessitates the development of high-loading solid-state cathodes with fast charging capability. However, electrochemical kinetics are severely delayed in thick cathodes due to tortuous ion transport pathways and slow solid-solid ion diffusion, which limit the achievable capacity of SSBs at high current densities. In this work, we propose a conductivity gradient cathode with low-tortuosity to enable facile ion transport and counterbalance ion concentration gradient, thereby overcoming the kinetic limitations and achieving fast charging capabilities in thick cathodes. The LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathodes deliver a room-temperature (RT) capacities of 147 and 110 mAh g −1 at 5 C and 10 C, respectively, and meanwhile achieve a RT areal capacity of 3.3 mAh cm −2 at 3 C, enabling SSBs simultaneously high energy and power densities. The universality of this strategy is demonstrated in LiFePO 4 cathodes, providing a novel solution for fast charging and large-scale application of high-loading SSBs.}, archive = {J_ANGEW}, author = {Guangzeng Cheng and Jinping Yu and Yonghui Wang and Zhengyu Ju and Yue Zhu and Weiqian Tian and Jingwei Chen and Huanlei Wang and Jingyi Wu and Guihua Yu}, doi = {10.1002/anie.202425357}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gradient design with low-tortuosity overcoming kinetic limitations in high-loading solid-state cathodes}, volume = {64}, year = {2025}, }
• (2025). All-in-one photoacid generators with Green/Red-light responsiveness and cooperative functionality. ANGEW, 64(15), e202425313. (www)

  @article{ , abstract = {Photoacid generators ( PAG s) are invaluable molecular tools that exhibited tremendous potential in emerging interdisciplinary researches of life-science, nanotechnology and smart materials. However, current PAG s are primarily mono-functional in terms of acid generation and rely on UV/deep-blue light excitation, posing a fundamental hurdle to their broader adoption. Developing cooperatively functioned PAG s with long-wavelength light responsiveness presents a formidable challenge due to the absence of suitable molecular scaffolds. Here, we introduce a newly-developed perylene bisimides PAG motif ( PBI-PAG ) that integrates desired multi-functionality and visible-light photo-reactivity. Taking advantages of characteristic opto-electronic properties of PBI scaffold, PBI-PAG s are capable of quantitative releasing (>99 %) a palette of acids upon green/red light (560–605 nm) excitation. Concurrently, a photo-generated counterpart is functioned as a photo-sensitizer that could perform cooperatively with acid as an anti-metastasis cancer therapy agent. These two processes constitute the first example of a cooperatively functioned PAG operated at substrate-adaptive wavelengths.}, archive = {J_ANGEW}, author = {Huichao Guo and Zhiwei Zhang and Yuhao Chen and Haochen Yang and Long Deng and Jinghong Dai and Muyu Cong and Bangsen Wang and Da-Hui Qu and Wei-Hong Zhu and Junji Zhang and He Tian}, doi = {10.1002/anie.202425313}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425313}, shortjournal = {Angew. Chem. Int. Edit.}, title = {All-in-one photoacid generators with Green/Red-light responsiveness and cooperative functionality}, volume = {64}, year = {2025}, }
• (2025). Tuning the acid hardness nature of cu catalyst for selective nitrate-to-ammonia electroreduction. ANGEW, 64(15), e202425262. (www)

  @article{ , abstract = {Electrocatalytic nitrate reduction reaction (NO 3 RR) in alkaline electrolyte presents a sustainable pathway for energy storage and green ammonia (NH 3 ) synthesis. However, it remains challenging to obtain high activity and selectivity due to the limited protonation and/or desorption processes of key intermediates. Herein, we propose a strategy to regulate the acid hardness nature of Cu catalyst by introducing appropriate modifier. Using density functional theory calculations, we firstly identified that the BaO-modified Cu showed optimal Gibbs free energies for key NO 3 RR steps, including the protonation of *NO and the desorption of *NH 3 . Experimentally, the BaO-modified Cu catalyst exhibited 97.3 % Faradaic efficiency (FE) for NH 3 with a yield rate of 356.9 mmol h −1 g cat −1 . It could also maintain high activity across a wide range of applied potentials and nitrate substrate concentrations. Detailed experimental and theoretical studies revealed that the Ba species could modulate the local electronic states of Cu, enhance the electron transfer rate, and optimize the adsorption/protonation/desorption processes of the N-containing intermediates, leading to the excellent catalytic performance for NO 3 − -to-NH 3 .}, archive = {J_ANGEW}, author = {Ruhan Wang and Shunhan Jia and Limin Wu and Libing Zhang and Xinning Song and Xingxing Tan and Chaofeng Zheng and Weixiang Li and Xiaodong Ma and Qingli Qian and Xinchen Kang and Qinggong Zhu and Xiaofu Sun and Buxing Han}, doi = {10.1002/anie.202425262}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning the acid hardness nature of cu catalyst for selective nitrate-to-ammonia electroreduction}, volume = {64}, year = {2025}, }
• (2025). Unlocking hexafluoroisopropanol as a practical anion-binding catalyst for living cationic polymerization. ANGEW, 64(15), e202425178. (www)

  @article{ , abstract = {Living cationic polymerization (LCP) is a classical technique for precision polymer synthesis; however, due to the high sensitivity of cationic active species towards chain-transfer/termination events, it is notoriously difficult to control polymerization under mild conditions, which inhibits its progress in advanced materials engineering. Here, we unlock a practical anion-binding catalytic strategy to address the historical dilemma in LCP. Our experimental and mechanistic studies demonstrate that commercially accessible hexafluoroisopropanol (HFIP), when used in high loading, can create higher-order HFIP aggregates to tame dormant-active species equilibrium via non-covalent anion-binding principle, in turn inducing distinctive polymerization kinetics behaviors that grant efficient chain propagation while minimizing competitive side reactions. This unique control mechanism delivers unprecedented polymerization activity and controllability across various electron-rich vinyl monomers under mild conditions, and provides easy access to high molecular weight polymers, block copolymers, and end-functionalized telechelic polymers. Also, the minimalistic structure of HFIP coupled with its convenient removal and recycle renders this approach easy to scale up, without concern for cost, sustainability and complicated work-up processes associated with previous systems. This study presents another universal and sustainable strategy for cationic macromolecular engineering, and will also stimulate further exploration of innovative non-covalent catalysis that enables more challenging living polymerization systems.}, archive = {J_ANGEW}, author = {Maosheng Li and Xiaodie Ma and Youhua Tao}, doi = {10.1002/anie.202425178}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425178}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking hexafluoroisopropanol as a practical anion-binding catalyst for living cationic polymerization}, volume = {64}, year = {2025}, }
• (2025). Crystalline, porous figure-eight-noded covalent organic frameworks. ANGEW, 64(15), e202425103. (www)

  @article{ , abstract = {Figure-eight macrocycles represent a fascinating class of π-conjugated units characterized by unique aesthetics and non-contact molecular crossing at the center. Despite progress in synthesis over the past century, research into inorganic, organic, and polymeric figure-eight materials remains in its infancy. Here we report the first examples of figure-eight covalent organic frameworks by condensing figure-eight knots to create extended porous figure-eight π architectures. A distinct feature is that polymerization interweaves figure-eight knots into double-decker layers, which upon supramolecular polymerization organize well-defined layer frameworks. The figure-eight frameworks exhibit a band gap of 2.3 eV and emit bright orange florescence with benchmark quantum yields. Remarkably, the donor-acceptor figure-eight skeletons convert the figure-eight knots into reduction centers and the linkers into oxidation sites upon light irradiation, enable charge transport and accumulation through π columns, while the built-in hydrophilic micropores allow rapid water and oxygen delivery via capillary effect. With these distinct features, the figure-eight frameworks function as a photocatalyst to produce hydrogen peroxide at high rate and efficiency with water/saltwater, oxygen/air, and light as sole inputs. This work paves a way to a new class of molecular frameworks, underpinning the study of well-defined figure-eight materials to explore unprecedented structures and functions so far we untouched.}, archive = {J_ANGEW}, author = {Yaling Li and Shanshan Tao and Yongzhi Chen and Xingyao Ye and Haipei Shao and Ming Lin and Yongfeng Zhi and Donglin Jiang}, doi = {10.1002/anie.202425103}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425103}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystalline, porous figure-eight-noded covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Where does the proton go? structure and dynamics of hydrogen-bond switching in aminophosphine chalcogenides. ANGEW, 64(15), e202425049. (www)

  @article{ , abstract = {Aminophosphates are the focus of research on prebiotic phosphorylation chemistry. Their bifunctional nature also makes them a powerful class of organocatalysts. However, the structural chemistry and dynamics of proton-binding in phosphorylation and organocatalytic mechanisms are still not fully understood. Aminophosphine chalcogenides, preserving the central H 2 N−P + −Ch − structural motif, represent well-suited molecular models that mimic proton-binding, hydrogen-bond switching and supramolecular self-assembling behavior of catalytically and prebiotically relevant molecules. Through spectroscopic (IR, 1 H DOSY, 15 N NMR), molecular dynamics, and computational investigations, the dynamic proton switching capability of aminophosphate analogs was demonstrated. It was shown under which conditions the amino (NH 2 ) or chalcogen (Ch) functions in H 2 N−P + −Ch − structural units are protonated. In fact, all conceivable modes of hydrogen-bonding were identified, revealing substantial differences between the oxygen derivative and the heavier congeners. Using coordinating anions, supramolecular zigzag- and cube-shaped arrangements were found in the solid-state and in solution. After break-up of the cube structure, the sulfides and selenides no longer form stable interactions with HCl molecules. In the absence of coordinating anions, however, protonation of the chalcogen function is preferred. In contrast to the oxygen derivative, the heavier protonated congeners show dynamic intramolecular proton-hopping between the chalcogen and the amino function.}, archive = {J_ANGEW}, author = {Tanja Huber and Gabriel Mayer and Manuel Kümper and Wagner Silva and Nicolò Fontana and Alexander Falk and Simon H. F. Schreiner and Johannes Gramüller and Alexander Scrimgeour and Emily Groß and Ruth M. Gschwind and Dominik Horinek and Patrick Nuernberger and Jonathan O. Bauer}, doi = {10.1002/anie.202425049}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425049}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Where does the proton go? structure and dynamics of hydrogen-bond switching in aminophosphine chalcogenides}, volume = {64}, year = {2025}, }
• (2025). High-entropy aqueous electrolyte induced formation of water-poor zn2+ solvation structures and gradient solid-electrolyte interphase for long-life zn-metal anodes. ANGEW, 64(15), e202425008. (www)

  @article{ , abstract = {Electrolyte engineering has emerged as an effective strategy for stabilizing Zn-metal anodes. However, a single solute or solvent additive is far from sufficient to meet the requirements for electrolyte cycling stability. Here, we report a new-type high-entropy electrolyte composed of equal molar amounts of Zn(OTf) 2 and LiOTf, along with equal volumes of H 2 O, triethyl phosphate, and dimethyl sulfoxide, which enhances electrolyte stability by increasing solvation entropy. Specifically, this well-designed high-entropy electrolyte reduces the content of solvated and free water molecules while forming a robust gradient solid-electrolyte interphase on the Zn anode surface, protecting the Zn anode from water-induced corrosion. Moreover, the cationic electrostatic shielding layer on the Zn anode effectively suppresses the “tip effect”, enabling the uniform deposition of Zn. The synergistic effects of this mixed electrolyte effectively leverage the properties of individual additives, significantly extending the cycle life of Zn-metal anodes. Consequently, the resulting Zn//Zn symmetric cell using this high-entropy electrolyte can operate over 8000 h at 1 mA cm −2 and 0.5 mAh cm −2 . To highlight, in a Zn//V 2 O 5 ⋅H 2 O pouch cell, it retains 83.1 % of initial capacity after 420 cycles at 1 A g −1 . Such multifunctional high-entropy electrolyte design provides a meaningful reference for stable Zn-metal anodes.}, archive = {J_ANGEW}, author = {Lin Lin and Zhipeng Shao and Shizhuo Liu and Peng Yang and Kaiping Zhu and Wubin Zhuang and Chaowei Li and Gengde Guo and Wenhui Wang and Guo Hong and Bing Wu and Qichong Zhang and Yagang Yao}, doi = {10.1002/anie.202425008}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202425008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy aqueous electrolyte induced formation of water-poor zn2+ solvation structures and gradient solid-electrolyte interphase for long-life zn-metal anodes}, volume = {64}, year = {2025}, }
• (2025). A ZnO-based catalytic system for the synthesis of hydrogen peroxide from air. ANGEW, 64(15), e202424984. (www)

  @article{ , abstract = {Hydrogen peroxide (H 2 O 2 ) has a wide range of applications as an eco-friendly and sustainable oxidant. However, the clean, efficient and convenient synthesis of this compound remains challenging. This work demonstrates a rationally designed electron-self-supplied catalytic system capable of generating H 2 O 2 from water and atmospheric oxygen without extra energy input. This catalytic system is made of a ZnO coating containing oxygen vacancies and a Zn substrate. The ZnO catalyst layer obtains electrons from the Zn substrate to synthesize H 2 O 2 . The H 2 O 2 concentration produced by this catalytic system is up to 17.9 mM without any secondary processing. This remarkably high concentration is attributed to the formation of a liquid film on the hydrophilic ZnO surface that promotes the oxygen reduction reaction by accelerating the transfer of oxygen from the ambient air to the catalyst surface. By integrating with atmospheric fog collection, this system can continuously collect H 2 O 2 directly from the air.}, archive = {J_ANGEW}, author = {Lan Wang and Chunyao Fang and Boran Xu and Yunlong Yu and Youmei Liu and Xianbiao Fu and Ang Cao and Qiangqiang Sun and Shaobing Zhou}, doi = {10.1002/anie.202424984}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424984}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A ZnO-based catalytic system for the synthesis of hydrogen peroxide from air}, volume = {64}, year = {2025}, }
• (2025). Porous 3 d-4 f coordination clusters for selective visible-light photocatalytic CO2 reduction to CO. ANGEW, 64(15), e202424805. (www)

  @article{ , abstract = {We report herein two families of porous coordination clusters (PCCs) with 216 nuclearity (M 120 RE 96 or PCC-216MR) and 300 nuclearity (Co 144 Gd 156 or PCC-300CG). For the first family M could be either nickel or cobalt, and RE = Pr, Nd, Sm, Eu, and Gd; while the latter features the highest nuclearity of transition-rare earth metal clusters. Characterized by their cube-like, hollow structures, these clusters exhibit the ability to absorb N 2 and CO 2 . Besides, these clusters can be dissolved in both aqueous and acetonitrile/methanol solutions, and capable of acting as homogeneous catalysts for converting CO 2 to CO under visible light. The gadolinium analogues of these clusters all show turnover numbers over 10000 and turnover frequencies over 1 s −1 . In particular, the nickel based bimetallic cluster (PCC-216NG) demonstrates nearly 100 % selectivity for the reduction product, which may open a new direction for the design and development of PCCs based catalysts.}, archive = {J_ANGEW}, author = {Wei-Peng Chen and Kai-Peng Bai and Man-Ting Lv and Shuang Ni and Chang Huang and Qing-Yuan Yang and Yan-Zhen Zheng}, doi = {10.1002/anie.202424805}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424805}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porous 3 d-4 f coordination clusters for selective visible-light photocatalytic CO2 reduction to CO}, volume = {64}, year = {2025}, }
• (2025). Coordination self-assembly induced hot exciton fluorescence and multi-source excitation long afterglow. ANGEW, 64(15), e202424795. (www)

  @article{ , abstract = {Metal-organic complexes with long afterglow luminescence have attracted extensive attention due to potential applications in display, sensing and information security. However, most of the metal-organic complex long afterglow materials reported so far are limited to the use of UV light as the excitation source, and the ambiguity of the structure-activity relationship makes the development of metal-organic complexes extremely limited. Herein, a series of metal-organic complexes with ultralong emission lifetime is constructed by coordination assembly of Zn(II) with three isomers. These complexes can emit afterglow when excited by UV light, blue LED, cell phone flashlight or even near-infrared light (800 nm) under ambient conditions, and the afterglow is also observed at 360 K. More interestingly, the inactivation pathway of the triplet exciton was altered by the strategy of supramolecular self-assembly, which leads to these complexes having hot exciton fluorescence (HEF) emission that is not present in the ligand. The relationship between structure and optical properties is investigated in detail by experiments and theoretical calculations. This work provides guidance for studying the modulation of optical properties by coordination interactions.}, archive = {J_ANGEW}, author = {Zhong-Hao Wang and Chen-Hui Liu and Hui-Li Sun and Lin Zheng and Mei Pan}, doi = {10.1002/anie.202424795}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424795}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coordination self-assembly induced hot exciton fluorescence and multi-source excitation long afterglow}, volume = {64}, year = {2025}, }
• (2025). Design, synthesis and application of chiral spirocyclic bisindoles. ANGEW, 64(15), e202424773. (www)

  @article{ , abstract = {While modifications of the privileged catalyst backbones, such as 1,1’-spirobiindane-7,7’-diol (SPINOL), have led to the development of diverse useful chiral catalysts, the incorporation of heteroarenes in such chiral spirocyclic structures has limitedly known. Herein we report the design of a type of chiral spirocyclic bisindole skeletons where the electronically distinct heteroarenes serve as direct anchor for functional sites. Separate approaches for the synthesis of two different families of such skeletons have been developed via chiral phosphoric acid and rhodium catalysis, respectively. Both strategies provided expedient access to the highly enantioenriched spiro-bisindoles, owing to not only the high nucleophilicity of the indole ring, but also the robust asymmetric control. These new skeletons have been demonstrated as backbones of effective chiral catalysts for both transition metal catalysis and organocatalysis.}, archive = {J_ANGEW}, author = {Jing-Yi Wang and Jianwei Sun}, doi = {10.1002/anie.202424773}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424773}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design, synthesis and application of chiral spirocyclic bisindoles}, volume = {64}, year = {2025}, }
• (2025). Switching CO2 electroreduction toward c2+ products and CH4 by regulating the dimerization and protonation in Platinum/Copper catalysts. ANGEW, 64(15), e202424749. (www)

  @article{ , abstract = {Copper (Cu)-based catalysts exhibit distinctive performance in the electrochemical CO 2 reduction reaction (CO 2 RR) with complex mechanism and sophisticated types of products. The management of key intermediates *CO and *H is a necessary factor for achieving high product selectivity, but lack of efficient and versatile strategies. Herein, we designed Pt modified Cu catalysts to effectively modulate the competitive coverage of those intermediates. The Pt single-atoms and Pt nanoparticles modified Cu catalysts (denoted as Cu-Pt 1 and Cu-Pt NPs ) precisely regulated the protonation and dimerization, with the faradaic efficiency (FE) of C 2+ products up to 70.4 % and the FE of CH 4 reaching 57.7 %, respectively. CO stripping experiments reveal that Pt 1 sites could enhance the adsorption of *CO, while Pt NPs exhibit *CO tolerance for H 2 O dissociation. In situ spectroscopic results further confirms that high coverage of *CO is achieved on Cu-Pt 1 , while *CHO on Cu-Pt NPs might generate by additional water dissociation. As elucidated by theoretical studies, the interfacial sites of Cu-Pt 1 would favor the *CO coverage promoting the evolution of *OCCO for C 2+ products while Pt NPs supplementarily accelerate H 2 O dissociation achieving *CHO for CH 4 . This work provides insights for efficient and targeted CO 2 conversion by atomically design of active sites with engineered key intermediates coverage.}, archive = {J_ANGEW}, author = {Tailei Hou and Jiexin Zhu and Hongfei Gu and Xinyuan Li and Yiqing Sun and Ze Hua and Ruiwen Shao and Cheng Chen and Botao Hu and Liqiang Mai and Shenghua Chen and Dingsheng Wang and Jiatao Zhang}, doi = {10.1002/anie.202424749}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switching CO2 electroreduction toward c2+ products and CH4 by regulating the dimerization and protonation in Platinum/Copper catalysts}, volume = {64}, year = {2025}, }
• (2025). Rational design two- or four-electron reaction pathway covalent organic frameworks for efficient and selective electrocatalytic hydrogen peroxide production. ANGEW, 64(15), e202424720. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) are often employed in oxygen reduction reactions (ORR) for hydrogen peroxide production due to their tunable structures and compositions. However, COF electrocatalysts require precise structural engineering, such as heteroatoms or metal site doping, to modulate the reaction pathway during the ORR process. In this work, we designed a tetraphenyl- p -phenylenediamine based COF electrocatalyst, namely TPDA-BDA, which exhibited excellent two-electron (2e) ORR performance with high H 2 O 2 selectivity of 89.7 % and faraday efficiency (FE) of 86.7 %, higher than the reported COFs to date for H 2 O 2 electrosynthesis. The theoretical and experimental results showed that the rate-determining step energy barrier for reduction of O 2 to OOH* intermediates was significantly reduced by replacing of bipyridine with biphenyl blocks, changing from 4e to 2e ORR reaction pathway. Also, the donor-acceptor characteristic and narrower optical band gap of TPDA-BDA COF enhanced the electronic conductivity and reduction ability, thus elevating the catalytic activity. As a result, the H 2 O 2 selectivity was maintained above 85 % even after 50 h stability test. This work reveals the structure-property relationship of COF electrocatalysts and provides a new strategy for rational design of high performance 2e ORR COF electrocatalysts for efficient and selective hydrogen peroxide production.}, archive = {J_ANGEW}, author = {Jiayi Liu and Wenjing Zhang and Jin Shen and Liang Feng and Yao Yao and Qiang Peng}, doi = {10.1002/anie.202424720}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424720}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design two- or four-electron reaction pathway covalent organic frameworks for efficient and selective electrocatalytic hydrogen peroxide production}, volume = {64}, year = {2025}, }
• (2025). Spatial confinement of a dual activatable DNAzyme sensor in the cavity of a DNA nanocage for logic-gated molecular imaging. ANGEW, 64(15), e202424684. (www)

  @article{ , abstract = {Despite intense interest in design of DNAzyme sensors for molecular detection and imaging in living cells, their intracellular applications are still hampered by limited spatial control and poor bio-stability. Here we present controlled spatial confinement of a rationally designed, microRNA (miRNA)-activatable DNAzyme sensor probe (mDz) within the cavity of DNA nanocage, enabling efficient intracellular delivery with improved bio-stability for AND-gate molecular imaging. The mDz that possesses inactive DNAzyme activity is designed by the introduction of a blocking DNA strand, while miR-21 mediated strand displacement reaction allows for the formation of an intact DNAzyme structure for metal-ion-mediated catalytic reaction. Furthermore, the DNA nanocage serves as a nanocarrier for intracellular delivery of mDz, in which the cavity is accessible to the dual targets for logic-gated molecular imaging, while the confinement effect can provide steric protection of mDz by obstructing nuclease from entering the cavity of the DNA nanocage, resulting in enhanced bio-stability and improved molecular imaging precision. This strategy paves a way for the engineering of activatable DNA nanosensors with both self-delivery and self-protection capabilities to detect diverse intracellular targets.}, archive = {J_ANGEW}, author = {Tingting Tu and Shuangyan Huan and Xueyan Feng and Guoliang Ke and Lele Li and Xiao-Bing Zhang}, doi = {10.1002/anie.202424684}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatial confinement of a dual activatable DNAzyme sensor in the cavity of a DNA nanocage for logic-gated molecular imaging}, volume = {64}, year = {2025}, }
• (2025). Structural isomerism of {Ag14}10+ nanocluster encapsulated by bowl-like polyoxometalates. ANGEW, 64(15), e202424499. (www)

  @article{ , abstract = {The structural isomerism of atomically precise nanoclusters provides a preeminent theoretical model to investigate the structure−property relationships. Herein, we synthesized three bowl-like polyoxometalate (POM)-encapsulated Ag nanoclusters (denoted as {Ag 14 (Sb 3 W 30 ) 2 }-1 , {Ag 14 (Sb 3 W 30 ) 2 }-1 a , and {Ag 14 (Sb 3 W 30 ) 2 }-2 ) via a facile one-pot solvothermal approach. Among them, for the first time, an unprecedented isomeric {Ag 14 } 10+ nanoclusters are obtained in polyoxoanions {Ag 14 (Sb 3 W 30 ) 2 }-1 and {Ag 14 (Sb 3 W 30 ) 2 }-2 , which should be probably induced by the different distribution of coordinating O atoms in two isomeric bowl-like {Sb 3 W 30 } ligands. Clusters {Ag 14 (Sb 3 W 30 ) 2 }-1 and {Ag 14 (Sb 3 W 30 ) 2 }-2 exhibit distinct electronic structures and physicochemical properties due to the different geometric structures of the {Ag 14 } 10+ nanoclusters, but both clusters can effectively catalyze the visible-light-driven hydrogen evolution with over 22,000 turnovers (TONs) after 6-hour photocatalysis.}, archive = {J_ANGEW}, author = {Manzhou Chi and Jianyu Wei and Zichen Zhao and Xiaoyi Liu and Wanting Sun and Yeqin Feng and Hongjin Lv and Guo-Yu Yang}, doi = {10.1002/anie.202424499}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424499}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural isomerism of {Ag14}10+ nanocluster encapsulated by bowl-like polyoxometalates}, volume = {64}, year = {2025}, }
• (2025). Metal-free multicatalytic decarbonylation of aldehydes driven by light. ANGEW, 64(15), e202424459. (www)

  @article{ , abstract = {A metal-free dual photo- and organocatalytic decarbonylation of aliphatic aldehydes is described for the first time. On the one hand, a wide range of tertiary aldehydes are smoothly decarbonylated thanks to the combination of thioxanthone as photocatalyst and diphenyl disulfide as organocatalyst. On the other hand, by simply using 4-CzIPN as photocatalyst instead of thioxanthone, various secondary aldehydes readily undergo decarbonylation in an orthogonal manner, via the in situ formation of 1,4-dihydropyridines. Both methodologies are compatible with various functional groups and are readily applied to the decarbonylation of complex molecules.}, archive = {J_ANGEW}, author = {Augustin Nouaille and Francesco Terzani and Yara Fakih and Jérôme Hannedouche and Emmanuel Magnier and Corinne Gosmini and Guillaume Dagousset}, doi = {10.1002/anie.202424459}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-free multicatalytic decarbonylation of aldehydes driven by light}, volume = {64}, year = {2025}, }
• (2025). Amplified production of a DNA decoy catalyzed by intracellular MicroRNA. ANGEW, 64(15), e202424421. (www)

  @article{ , abstract = {DNA decoys inhibit cellular transcription factors and are expected to be among the nucleic acid drugs used to downregulate the transcription process. However, spatially controlling the on/off efficacy of DNA decoys to avoid side effects on normal cells is challenging. To reduce undesired decoy function in normal cells, we adopted catalytic hairpin assembly (CHA) to produce a DNA duplex from a hairpin DNA pair in response to a specific microRNA (miRNA). We designed the DNA hairpin pairs to form a DNA decoy that binds to nuclear factor kappa B (NF-κB), whose overexpression is related to many diseases, including cancer. The transformation of the DNA hairpin pair to the NF-κB DNA decoy was catalyzed by miR-21, which is expressed in various types of cancers. Intracellular CHA progression and the inhibitory effect against NF-κB were observed only in miR-21 overexpressing cancer cells. The intracellular miR-21-catalyzed production of the NF-κB DNA decoy has the potential to reduce side effects on normal cells, thereby strengthening the therapeutic profile of the CHA-decoy system. The ability to customize the combination of catalytic miRNA and target transcription factors would allow our technology to serve as a “personalized drug discovery system” for a variety of challenging diseases, including cancer.}, archive = {J_ANGEW}, author = {Soshu Yasuda and Kunihiko Morihiro and Shuichiro Koga and Akimitsu Okamoto}, doi = {10.1002/anie.202424421}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424421}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amplified production of a DNA decoy catalyzed by intracellular MicroRNA}, volume = {64}, year = {2025}, }
• (2025). Shifting lithium amide reactivity to the radical domain: Regioselective radical C−H functionalization of 3-iodooxetane for the synthesis of 1,5-dioxaspiro[2.3]hexanes. ANGEW, 64(15), e202424346. (www)

  @article{ , abstract = {Strained spiro-heterocycles (SSHs) have gained significant attention within the medicinal chemistry community as promising sp 3 -rich bioisosteres for their aromatic and non-spirocyclic counterparts. We herein report access to an unprecedented spiro-heterocycle—1,5-dioxaspiro[2.3]hexane. Our synthetic approach leverages a lithium-amide induced single-electron transfer to benzophenones generating an N -centered radical and a ketyl radical anion—reminiscent of a frustrated radical pair. This pair works synergistically to selectively abstract the β-hydrogen from 3-iodooxetane, initiating an exergonic radical-radical coupling reaction. This process enables the formation of the desired bond between the oxetane core and benzophenone derivatives, ultimately yielding the novel 1,5-dioxaspiro[2.3]hexane core. The stability and synthetic utility of the novel 1,5-dioxaspiro[2.3]hexane motif are showcased. An in-depth mechanistic investigation is presented, including cyclic voltammetry studies, as well as computational calculations and experiments to support the mechanism of this new single electron synthetic tactic.}, archive = {J_ANGEW}, author = {Philipp Natho and Marco Colella and Annarita Vicenti and Giuseppe Romanazzi and Faizan Ullah and Nadeem S. Sheikh and Andrew J. P. White and Francesco Pasca and Renzo Luisi}, doi = {10.1002/anie.202424346}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424346}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Shifting lithium amide reactivity to the radical domain: Regioselective radical C−H functionalization of 3-iodooxetane for the synthesis of 1,5-dioxaspiro[2.3]hexanes}, volume = {64}, year = {2025}, }
• (2025). Synergizing mg single atoms and ru nanoclusters for boosting the ammonia borane hydrolysis to produce hydrogen. ANGEW, 64(15), e202424316. (www)

  @article{ , abstract = {Development of efficient catalysts with high H 2 O molecule activation ability holds great importance for H 2 production. Herein, enzyme-mimic Mg single atoms catalysts (SACs) coordinated by B/N-doped carbon nanotube (BNC), was constructed as a high-performance support for ruthenium (Ru) nano-clusters. Dual functions of Mg SACs were discovered, where the Mg atoms beneath Ru catalysts built an interfacial electron polarization, inducing electron transfer from Ru to the Mg-BNC support. In addition, the oxyphilic Mg SACs adjacent to the Ru catalysts could actively participate in H 2 O adsorption. The combination of experimental characterization, reaction kinetics study and density functional theory (DFT) calculations validated a stronger intrinsic H 2 O activation capability at the positive Ru sites. Meanwhile, the synergistic Mg SACs jointly contribute to the acceleration of the sluggish H 2 O dissociation process in ammonia borane (AB) hydrolysis reaction, resulting in exceptional hydrogen production activity and catalytic stability, outperforming most state-of-the-art Ru-based catalysts. This work provides a new strategy for utilizing alkaline earth metals as both the electronic promoter and the reactant activator, offering inspiration for the development of advanced heterogeneous catalysts.}, archive = {J_ANGEW}, author = {Shumin Xie and Shuheng Tian and Jialei Yang and Ning Wang and Qixin Wan and Maolin Wang and Jinxun Liu and Jing Zhou and Pengfei Qi and Kunyan Sui and Xingyun Li and Ding Ma and Xiu Song Zhao}, doi = {10.1002/anie.202424316}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424316}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergizing mg single atoms and ru nanoclusters for boosting the ammonia borane hydrolysis to produce hydrogen}, volume = {64}, year = {2025}, }
• (2025). Topological supramolecular complexation of metal-organic polyhedra for tunable interconnected hierarchical microporosity in amorphous form. ANGEW, 64(15), e202424238. (www)

  @article{ , abstract = {The precise engineering of microporosity is challenging due to the interference at the sub-nm scale from unexpected structural flexibility and molecular packing. Herein, the concept of topological supramolecular complexation is proposed for the feasible fabrication of hierarchical microporosity with broad tunability in amorphous form. The 2.5 nm metal-organic polyhedra (MOP) are complexed with quadridentate ligands through hydrogen and coordination bonding while the mismatch between the MOPs’ cuboctahedron and ligands’ tetrahedron topology leads to frustrated packing with extrinsic microporosity. Amorphous supramolecular frameworks can be obtained that integrate the intrinsic microporosity of the MOPs with the extrinsic porosity from the frustrated packing. The topologies, sizes and flexibility of ligands as well as ligand/MOP ratios are systemically varied, and the pore size distribution can be precisely adjusted. The hierarchical structures ranging from molecular packing to the morphologies of meso-scale assemblies are probed using ultra-small, small- and wide-angle X-ray scattering, enabling the quantitative evaluation of the micropores interconnectivity for the understanding of gas permeation performance. Gas separation membranes with permselectivity surpassing the Robeson upper bound can be designed. The findings not only give insight into the microscopic mechanism of supramolecular frustrated packing from topological design, but also pave new avenues for the cost-effective fabrications of microporous frameworks.}, archive = {J_ANGEW}, author = {Yuan Liu and Binghui Xue and Jiadong Chen and Jinling Cai and Panchao Yin}, doi = {10.1002/anie.202424238}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424238}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topological supramolecular complexation of metal-organic polyhedra for tunable interconnected hierarchical microporosity in amorphous form}, volume = {64}, year = {2025}, }
• (2025). Prescribing DNA origami barrel-directed subtractive patterning of nanoparticles for crystalline superstructure assembly. ANGEW, 64(15), e202424230. (www)

  @article{ , abstract = {Long-range ordered lattices formed by the directed arrangement of colloidal particles hold significant promise for applications such as photonic crystals, plasmonic metamaterials, and semiconductor electronics. Harnessing regioselective interactions through DNA-mediated assembly is a promising approach to advancing colloidal assembly. Despite efforts to engineer microscale patchy particles using sequence-specific binding properties of DNA, the control of patch formation on nanoscale isotropic spherical nanoparticles remains challenging. We demonstrate a subtractive patterning strategy using barrel-shaped DNA origami (DNA barrel) to selectively block surfaces of DNA-coated gold nanospheres and create regiospecific patches. By designing binding positions and geometric parameters of DNA barrels, we can achieve controlled accessibility to nanosphere surfaces, forming patchy nanoparticles with tunable patch numbers and sizes. This strategy enables the construction of multidimensional superstructures with well-defined stereo relationships, represented by an unprecedented graphane-like bilayered superlattice. Furthermore, we developed a geometrical model that accounts for anisotropic particle bonding and steric hindrance, elucidating the relationship between architectural outcomes and the structural parameters of DNA-barrel-directed patchy nanoparticles, and enabling reverse engineering designs of potential assembly symmetries. This approach opens new avenues for generating nanoparticle assemblies with distinct symmetries and properties.}, archive = {J_ANGEW}, author = {Longjiang Ding and Wenhe Ma and Xiaoliang Chen and Haozhi Wang and Haitao Song and Chunhai Fan and Xiaoguo Liu and Guangbao Yao}, doi = {10.1002/anie.202424230}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424230}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Prescribing DNA origami barrel-directed subtractive patterning of nanoparticles for crystalline superstructure assembly}, volume = {64}, year = {2025}, }
• (2025). Assisted solubilization strategy in spiro-OMeTAD for thermally and mechanically stable perovskite solar cells. ANGEW, 64(15), e202424191. (www)

  @article{ , abstract = {The ions migration and de-doping reactions caused by conventional doping seriously jeopardizes the thermal stability of perovskite solar cells (PVSCs) based on spiro-OMeTAD as hole transport layer (HTL), which poses a significant challenge for subsequent commercialization. To address these issues, a novel assisted solubilization strategy has been firstly developed using deep eutectic solvent (DES) synthesized from N-(cyanomethyl)acetamide (NCMA) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). NCMA can form multiple strong interaction modes with LiTFSI through N−H⋅⋅⋅O hydrogen bonding and Li−O/Li−N coordination, which effectively inhibits Li + ions migration at high temperature and increases solubility of LiTFSI in chlorobenzene without acetonitrile and 4-tert-butylpyridine (tBP), fundamentally solving de-doping reaction. In addition, the molecular network with abundant functional groups in DES improves fracture energy of perovskite/spiro-OMeTAD interface and enhances interfacial adhesion via strong chelation with perovskite and Ag electrode. Consequently, benefiting from tBP removement and inhibited ions migration, the optimized PVSCs achieve a power conversion efficiency (PCE) of 25.02 %, and the unencapsulated device retains over 90 % of initial PCE at 85 °C, 40 % RH for 1200 h (ISOS-D-2 standard). This innovative assisted solubilization strategy represents a critical step toward improving device stability and accelerating the commercialization of PVSCs.}, archive = {J_ANGEW}, author = {Xueying Wang and Yang Zhong and Yikun Liu and Xiao Luo and Binlou Gao and Licheng Tan and Yiwang Chen}, doi = {10.1002/anie.202424191}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Assisted solubilization strategy in spiro-OMeTAD for thermally and mechanically stable perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Paired photoproduction of H2O2 and 3,4-dihydroisoquinoline over covalent pyrene-(Thio)urea frameworks with electron push-pull effect. ANGEW, 64(15), e202424110. (www)

  @article{ , abstract = {Pairing photocatalytic 1,2,3,4-tetrahydroisoquinoline semi-dehydrogenation reaction (THIQ-SDR) with two-electron oxygen reduction reaction (2e − ORR) is a green solar to chemical strategy by simultaneously utilizing the photo-excited electrons and holes. However, it is still short of high-efficiency photocatalyst to drive two reactions above. In the present work, crystalline pyrene-thiourea/urea covalent organic frameworks (COF−Py−S and −O) were synthesized and demonstrated as high-performance metal-free photocatalysts. In particular, COF−Py−S exhibited higher 2e − ORR to H 2 O 2 yield rate of ~19 mmol g −1 h −1 under visible light and finally solid H 2 O 2 products (Na 2 CO 3 ⋅ 1.5H 2 O 2 ) was collected after long-time irradiation. Under natural sunlight conditions, the H 2 O 2 production rate over COF−Py−S further increased to ~51 mmol g −1 h −1 , among the best COF photocatalysts. COF−Py−S also showed high THIQ-SDR conversion (~100 %) with 3,4-dihydroisoquinoline (DHIQ) selectivity of ~92 %. Theoretical calculations reveal stronger electron push-pull effect of COF−Py−S than COF−Py−O, enhancing its photoinduced charge carries, and a four-step 2e − ORR mechanism with thiourea as the active sites has been confirmed as well as the mechanism of THIQ-SDR to DHIQ, featuring lower energy barriers for O 2 adsorption and *HOOH desorption over thiourea units. This work provides a paired photosynthesis strategy of H 2 O 2 and DHIQ over high-efficiency pyrene-(thio)urea COF photocatalysts with electron push-pull effect.}, archive = {J_ANGEW}, author = {Tao Yang and Fantao Kong and Yue Chen and Aiguo Kong and Xiangzhi Cui and Jianlin Shi}, doi = {10.1002/anie.202424110}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424110}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Paired photoproduction of H2O2 and 3,4-dihydroisoquinoline over covalent pyrene-(Thio)urea frameworks with electron push-pull effect}, volume = {64}, year = {2025}, }
• (2025). The proximal protonation source in Cu−NHx−C single atom catalysts selectively boosts CO2 to methane electroreduction. ANGEW, 64(15), e202424098. (www)

  @article{ , abstract = {Regulating the coordination environment of active sites has proved powerful for tapping into their catalytic activity and selectivity in homogeneous catalysis, yet the heterogeneous nature of copper single-atom catalysts (SACs) makes it challenging. This work reports a bottom-up approach to construct a SAC (rGO@Cu−N(H x )−C) by inlaying preformed amine coordinated Cu 2+ units into reduced graphene oxide (rGO), permitting molecular level revelation on how the proximal N-site functional groups (N−H or N−CH 3 ) impact on the carbon dioxide reduction reaction (CO 2 RR). It is demonstrated that the N−H moiety of rGO@Cu−NH x −C can serve as an in situ protonation agent to accelerate the CO 2 -to-methane reduction kinetics, delivering a methane current density (163 mA/cm 2 ) 2.42-times that with the -CH 3 substituted counterpart rGO@Cu−N−C. Operando spectroscopic studies and theoretical calculations elucidate that the high methane faradaic efficiency (77.1 %) achieved here is enabled by opening up the energetically favorable formyl pathway (*OCHO pathway) against the traditional *CO pathway that normally leads to various CO 2 RR products other than methane. Our strategy sets the stage to precisely modulate single-atom catalysts for efficient and selective electrochemical CO 2 reduction.}, archive = {J_ANGEW}, author = {Rongming Cai and Hong Zhu and Fei Yang and Min Ju and Xianzhen Huang and Jian Wang and M. Danny Gu and Jiali Gao and Shihe Yang}, doi = {10.1002/anie.202424098}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424098}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The proximal protonation source in Cu−NHx−C single atom catalysts selectively boosts CO2 to methane electroreduction}, volume = {64}, year = {2025}, }
• (2025). SN2−Reaction− bonding-heterointerface strengthens buried adhesion and orientation for advanced perovskite solar cells. ANGEW, 64(15), e202424046. (www)

  @article{ , abstract = {Traditionally weak buried interaction without customized chemical bonding always goes against the formation of high-−quality perovskite film that highly determines the efficiency and stability of perovskite solar cells. To address this issue, herein, we propose a bimolecular nucleophilic substitution reaction (S N 2) driving strategy to idealize the robust buried interface by simultaneously decorating underlying substrate and functionalizing [PbX 6 ] 4− octahedral framework with iodoacetamide and thiol molecules, respectively. Theoretical and experimental results demonstrate that a strong S N 2 reaction between exposed halogen and thiol group in two molecules occurs, which not only benefits the reinforcement of buried adhesion, but also triggers target-point-oriented crystallization, synergistically upgrading the upper perovskite film quality and accelerating interfacial charge extraction–transfer behavior. Benefiting from the suppressed nonradiative recombination, as a result, an all-air-processed carbon–based all-inorganic CsPbI 2 Br device achieves an enhanced efficiency of 15.14 %, more importantly, with significantly prolonged long-term stability under harsh conditions. This unique reaction–driven buried interface provides a new path for manipulating perovskite growth and obtaining advanced perovskite photovoltaics.}, archive = {J_ANGEW}, author = {Naimin Liu and Jialong Duan and Chenlong Zhang and Jinyue Zhang and Yueyang Bi and Linzheng Ma and Dongmei Xu and Jun Gao and Xingxing Duan and Jie Dou and Qiyao Guo and Benlin He and Yuanyuan Zhao and Qunwei Tang}, doi = {10.1002/anie.202424046}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424046}, shortjournal = {Angew. Chem. Int. Edit.}, title = {SN2−Reaction− bonding-heterointerface strengthens buried adhesion and orientation for advanced perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Regulating interphase chemistry by targeted functionalization of hard carbon anode in ester-based electrolytes for high-performance sodium-ion batteries. ANGEW, 64(15), e202424028. (www)

  @article{ , abstract = {Commercial hard carbon (HC) anode suffers from unexpected interphase chemistry rooted in the parasitic reactions between surface oxygen-functional groups and ester-based electrolytes. Herein, an innovative strategy is proposed to regulate interphase chemistry by tailoring targeted functional groups on the HC surface, where highly active undesirable oxygen-functional groups are skillfully converted into a Si−O−Si molecular layer favorable for anchoring anions. Then, an inorganic/organic hybrid solid electrolyte interphase with low interfacial charge transfer resistance and enhanced cycling durability is constructed successfully. Consequently, the modified HC anode delivers an excellent rate capability of 206.2 mAh g −1 at 0.5 A g −1 and a remarkable capacity retention of 92.5 % after 1000 cycles at 1.0 A g −1 . Moreover, the coin-type full-cell equipped with Na 2 Fe[Fe(CN) 6 ] cathode exhibits an exceptional capacity retention ratio of 80.9 % after 800 cycles at 1C. The present simple and effective interfacial modification strategy offers a promising and alternative avenue for promoting the development and practicability of HC anode in ester-based electrolytes for sodium-ion batteries.}, archive = {J_ANGEW}, author = {Guangxiang Zhang and Chuankai Fu and Shuyang Gao and Haoquan Zhao and Chi Ma and Ziwei Liu and Shuai Li and Zhijin Ju and Hua Huo and Pengjian Zuo and Geping Yin and Tiefeng Liu and Yulin Ma}, doi = {10.1002/anie.202424028}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202424028}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating interphase chemistry by targeted functionalization of hard carbon anode in ester-based electrolytes for high-performance sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Taming the ion-dipole interaction via rational diluent selection for low-temperature li-metal batteries. ANGEW, 64(15), e202423940. (www)

  @article{ , abstract = {Developing advanced electrolytes with high Li affinity is crucial for achieving long-cycling lithium metal batteries (LMBs). However, the strong Li + -solvent interactions in conventional electrolytes often induce difficult Li + desolvation especially under low-temperature conditions, resulting in the formation of fragile electrode interfaces involving solvents, and thus dissatisfactory cycling stability of LMBs. Herein, by introducing various diluents into the lithium hexafluorophosphate in 1, 2-dimethoxyethane electrolyte, we reveal that Li + desolvation is influenced by not only the diluent-solvent interaction but also the diluent-anion interaction. Based on these findings, a diluent selection parameter (DSP), which is calculated based on the product of interaction energies of diluent-solvent/diluent-Li + and diluent-anion/diluent-Li + , is proposed for diluent selection. A diluent with a larger DSP is more favorable for promoting Li + desolvation and improving the low-temperature performance of LMBs. With the rationally selected 1, 2-dichloroethane diluent (DSP=3.95), the Li Cu cell enables high Li reversibility (98.5 % after 300 cycles). Li LiFePO 4 cell barely loses capacity at −20 °C for 300 cycles. The Li LiNi 0.8 Co 0.1 Mn 0.1 O 2 cell with the anode-to-cathode capacity ratio of 2.7 retains 87 % capacity retention after 100 cycles. This work provides new insights into taming strong Li-solvent interactions and offers a new paradigm for advanced electrolyte design.}, archive = {J_ANGEW}, author = {Zhenglu Zhu and Yan Li and Jie Ji and Xiaoqun Qi and Junqing Pan and Jiwei Ma and Long Qie and Yunhui Huang}, doi = {10.1002/anie.202423940}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423940}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Taming the ion-dipole interaction via rational diluent selection for low-temperature li-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Multiple protophilic redox-active sites in reticular organic skeletons for superior proton storage. ANGEW, 64(15), e202423936. (www)

  @article{ , abstract = {Protons (H + ) with the smallest size and fastest redox kinetics are regarded as competitive charge carriers in the booming Zn-organic batteries (ZOBs). Developing new H + -storage organic cathode materials with multiple ultralow-energy-barrier protophilic sites and super electron delocalization routes to propel superior ZOBs is crucial but still challenging. Here we design multiple protophilic redox-active reticular organic skeletons (ROSs) for activating better proton storage, triggered by intermolecular H-bonding and π–π stacking interactions between 2,6-diaminoanthraquinone and 2,4,6-triformylphloroglucinol nanofibrous polymer. ROSs expose reticular electron delocalization geometries to fully access build-in protophilic carbonyl sites and promote ultrarapid H + migration with an ultralow activation energy (0.13 vs. 0.29 eV of Zn 2+ ions), thus delivering high capacity (359 mAh g −1 ) and large-current survivability (100 A g −1 ). Moreover, the extended interconnected reticular structures strengthen the anti-dissolution of ROSs in aqueous electrolytes, affording long-lasting proton-storage activity in ZOBs to a superior level (60,000 cycles at 20 A g −1 ). Systematic studies identify the source of excellent charge storage as high-kinetics H + -coupled five-electron redox process of carbonyl motifs in superstable ROSs. These findings can be of importance for evoking superior proton activity in multiple redox organics to build advanced Zn-organic batteries.}, archive = {J_ANGEW}, author = {Yehui Zhang and Ziyang Song and Qi Huang and Yaokang Lv and Lihua Gan and Mingxian Liu}, doi = {10.1002/anie.202423936}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423936}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple protophilic redox-active sites in reticular organic skeletons for superior proton storage}, volume = {64}, year = {2025}, }
• (2025). A high-capacity manganese-metal battery with dual-storage mechanism. ANGEW, 64(15), e202423921. (www)

  @article{ , abstract = {As a promising post lithium-ion-battery candidate, manganese metal battery (MMB) is receiving growing research interests because of its high volumetric capacity, low cost, high safety and high energy-to-price ratio. However, the low energy density, mainly constrained by scarce choices and unsatisfying capacity of cathodes, strictly bottlenecks the development of MMBs. In this work, a new class of cathodes based on novel dual-storage mechanism (DSM) are reported. Working principles of DSM are revealed and deeply understood via ex situ X-ray diffraction and X-ray photoelectron spectroscopy. Besides, a proof-of-concept DSM-based Cu 1.8 S cathode, which shows the highest specific capacity of 220 mAh g −1 and 97.1 % higher energy density than previously reported cathodes in storing Mn 2+ ions, is presented. The key determinants on DSM and design strategies for next-generation cathodes are revealed via theoretical calculations. This work provides a new class of high-capacity cathode materials for MMBs, which is expected to draw inspirations to further enhance the energy density of MMBs.}, archive = {J_ANGEW}, author = {Dongyang Shen and Guili Zhao and Taoli Jiang and Hongxu Liu and Ruihao Luo and Zuodong Zhang and Ziwei Zhang and Jinghao Chen and Jingwen Xu and Yuancheng Feng and Peiyan Tong and Shunxin Tan and Yidi Wang and Zhenshan Lv and Xiangyang Li and Wei Chen}, doi = {10.1002/anie.202423921}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423921}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A high-capacity manganese-metal battery with dual-storage mechanism}, volume = {64}, year = {2025}, }
• (2025). Towards the stable chelation of Radioantimony(V) for targeted auger theranostics. ANGEW, 64(15), e202423878. (www)

  @article{ , abstract = {Antimony-119 ( 119 Sb) is one of the most attractive Auger-electron emitters identified to date, but it remains practically unexplored for targeted radiotherapy because no chelators have been identified to stably bind this metalloid in vivo. In a departure from current studies focused on chelator development for Sb(III), we explore the chelation chemistry of Sb(V) using the tris-catecholate ligand TREN-CAM. Through a combination of radiolabeling, spectroscopic, solid-state, and computational studies, the radiochemistry and structural chemistry of TREN-CAM with 1XX/nat Sb(V) were established. The resulting [ 1XX Sb]Sb–TREN-CAM complex remained intact for several days in human serum, signifying high stability under biological conditions. Finally, the first in vivo single photon emission computed tomography and positron emission tomography imaging studies were carried out using 117 Sb, the diagnostic analogue of 119 Sb. These studies revealed marked differences in the uptake and distribution of activity in mice administered unchelated [ 117 Sb]Sb(OH) 6 – versus [ 117 Sb]Sb–TREN-CAM, suggesting that 117 Sb is largely retained by TREN-CAM over the time course of the study. Collectively, these findings demonstrate the most physiologically stable complex of no-carrier-added 1XX Sb yet reported, offering new promise for the clinical implementation of radioantimony in nuclear medicine. Our results also establish the feasibility of 117 Sb as an elementally matched partner to 119 Sb for theranostic applications.}, archive = {J_ANGEW}, author = {Aeli P. Olson and Briana R. Schrage and Md Faizul Islam and Lesta S. Fletcher and Francesca Verich and Morgan A. Dierolf and Eduardo Aluicio-Sarduy and Kaelyn V. Becker and Darren M. Driscoll and Nidhi Girish and Megan E. Simms and Vilmos Kertesz and Frankie D. White and Eszter Boros and Alexander S. Ivanov and Jonathan W. Engle and Nikki A. Thiele}, doi = {10.1002/anie.202423878}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423878}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards the stable chelation of Radioantimony(V) for targeted auger theranostics}, volume = {64}, year = {2025}, }
• (2025). Reconfiguring terminal species of bituminous coal to steer hard carbon toward high-capacity and fast sodium storage. ANGEW, 64(15), e202423864. (www)

  @article{ , abstract = {Hard carbons derived from coal precursors have shown bright industrial prospect as the low cost anode materials of sodium-ion batteries. However, it is of extreme necessity yet challenge to regulate carbon microstructure toward superior sodium energy storage. In this study, we propose a powerful chemical reconfiguration tactic to steer hard carbons toward high-capacity and fast sodium storage. The functional species on the edge/plane terminals of bituminous coal are finely reconfigured by nitri-oxidation treatment for effectively inhibiting the reordering of carbon layers under high temperature, thereby creating rich ultramicropores/closed pores and expanded interlayer spacing. These structural merits enable the hard carbon to garner an enhanced capacity of 356 mAh g −1 along with a high initial Coulombic efficiency of 88.1 % and long lifespan. More impressively, the sodium storage kinetics is substantially sped up with a large capacity of 215 mAh g −1 retained at a high-rate of 2 A g −1 . This work will afford a fresh methodology for precursor modulation to accelerate the real-world practice of hard carbons toward advanced sodium-ion batteries.}, archive = {J_ANGEW}, author = {Yaxin Huang and Zhidong Hou and Jianfang Wang and Yongli Li and Ting Ma and Ding Nan and Chunguang Wei and Jian-Gan Wang}, doi = {10.1002/anie.202423864}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reconfiguring terminal species of bituminous coal to steer hard carbon toward high-capacity and fast sodium storage}, volume = {64}, year = {2025}, }
• (2025). Halogenated trityl cations as easy-to-access super electrophiles. ANGEW, 64(15), e202423857. (www)

  @article{ , abstract = {Herein, we present the easy-to-access synthesis of the perfluorotrityl cation ( 15F + ) with commercial GaCl 3 and the further functionalization of the para -fluorine atoms of 15F + via halodefluorination using trimethylsilyl halides TMSX (X=Cl, Br). This gives access to equally reactive halogenated trityl derivatives ( p -3Cl12F + and p -3Br12F + ), which can be handled at room temperature. The impact of the para -exchange on the electronic structure is determined by NMR and UV/Vis spectroscopy. Finally, the new synthons′ high hydride ion affinities are demonstrated computationally and experimentally by hydride abstraction from the short-chain, linear alkanes n -pentane and n -butane.}, archive = {J_ANGEW}, author = {Johanna Schlögl and Amelie L. Brosius and Ahmet N. Toraman and Anja Wiesner and Simon Steinhauer and Carsten Müller and Sebastian Riedel}, doi = {10.1002/anie.202423857}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423857}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogenated trityl cations as easy-to-access super electrophiles}, volume = {64}, year = {2025}, }
• (2025). Robust mechanically interlocked network ionogels. ANGEW, 64(15), e202423847. (www)

  @article{ , abstract = {Ionogels have attracted considerable attention as versatile materials due to their unique ionic conductivity and thermal stability. However, relatively weak mechanical performance of many existing ionogels has hindered their broader application. Herein, we develop robust, tough, and impact-resistant mechanically interlocked network ionogels ( IG MINs) by incorporating ion liquids with mechanical bonds that can dissipate energy while maintain structural stability. Profiting from the dynamic yet stable nature of the mechanically interlocked networks, IG MINs exhibit high tensile strength (9.6 MPa), fracture energy (39 kJ/m 2 ), and toughness (25.9 MJ/m 3 ), along with a high elongation rate (473 %) and excellent impact resistance and shape memory, resulting in overall performance that surpasses most reported ionogels. Furthermore, in the application of strain sensors for monitoring the gait of crawling robots, the toughness and robustness of IG MINs ensure their ability to consistently output stable electrical signals during the stretching and contraction processes, thereby highlighting their practical application potential. Our work provides a new research strategy for toughening ionogels and promotes the development of mechanically interlocked materials.}, archive = {J_ANGEW}, author = {Mengling Yang and Jinhao Li and Chunyu Wang and Li Yang and Zhiwei Fan and Wenbin Wang and Guoquan Liu and Lin Cheng and Shaolei Qu and Zhaoming Zhang and Jiang Zou and Wei Yu and Guoying Gu and Xuzhou Yan}, doi = {10.1002/anie.202423847}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust mechanically interlocked network ionogels}, volume = {64}, year = {2025}, }
• (2025). Nanopore-based high-resolution detection of multiple post-translational modifications in protein. ANGEW, 64(15), e202423801. (www)

  @article{ , abstract = {Protein post-translational modifications (PTMs) play crucial roles in various cellular processes. Despite their significance, only a few PTMs have been extensively studied at the proteome level, primarily due to the scarcity of reliable, convenient, and low-cost sensing methods. Here, we present a straightforward and effective strategy for detecting PTMs on short peptides through host-guest interaction-assisted nanopore sensing. Our results demonstrate that the identity of 13 types of PTMs in a specific position of a phenylalanine-containing peptide could be determined via current blockage during translocation of the peptide through α-hemolysin nanopores in the presence of cucurbit[7]uril. Furthermore, we extend this strategy by incorporating a short peptide into the probe, enabling the discrimination of various PTMs, positional isomers, and even multiple PTMs on the target peptide. With ongoing improvements, our method holds promise for practical applications in sensing PTMs in biologically relevant samples, offering an efficient alternative to traditional mass spectrometry approaches.}, archive = {J_ANGEW}, author = {Ziyi Li and Yakun Yi and Yun Zhang and Yuanyuan Xiao and Qianyuan Ren and Ke Zhou and Lei Liu and Hai-Chen Wu}, doi = {10.1002/anie.202423801}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423801}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanopore-based high-resolution detection of multiple post-translational modifications in protein}, volume = {64}, year = {2025}, }
• (2025). Chemiluminescence resonance energy transfer for targeted photoactivation of ion channels in living cells. ANGEW, 64(15), e202423792. (www)

  @article{ , abstract = {The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate oxidative stress-sensitive membrane channels in situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on a conjugated oligomer, oligo( p -phenylenevinylene)-imidazolium (OPV−Im), designed for the activation of transient receptor potential melastatin 2 (TRPM2) calcium channels in situ by superoxide anion (O 2 ⋅ − ) without requiring external light sources. The OPV−Im oligomer targeted the cell membrane efficiently, leading to the activation of TRPM2 channels in situ by the CRET process and subsequent intracellular calcium overload. This cascade resulted in mitochondrial damage and inhibition of autophagy, ultimately inducing cell apoptosis. Additionally, this strategy could be applied for the selective killing of tumor cells that overexpress TRPM2 ion channels and for inhibiting the growth of three-dimensional (3D) tumor spheroids. Our system offers a novel approach for regulating ion channel activity and oxidative stress in living cells compared to optogenetics and photodynamic therapy.}, archive = {J_ANGEW}, author = {Gang Song and Zhiwen Yang and Junjie Cheng and Hongrui Lin and Yiming Huang and Fengting Lv and Haotian Bai and Shu Wang}, doi = {10.1002/anie.202423792}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423792}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemiluminescence resonance energy transfer for targeted photoactivation of ion channels in living cells}, volume = {64}, year = {2025}, }
• (2025). Chemical energy lights up europium-based ultra-bright afterglow for bioanalysis application. ANGEW, 64(15), e202423791. (www)

  @article{ , abstract = {Photochemical afterglow materials are gaining great attention for the property to continuously emit light after the excitation source is removed. However, their limited luminescence quantum yield (QY) and brightness hinder the use in biological applications. In this study, we introduce a novel photochemical afterglow system that combines a newly designed photoenergy cache unit (PCU) with an emitter through coordination covalent bonds. The PCU boasts a dark state to significantly emit photons only through chemiexcitation in the process of photochemical reactions, facilitating direct energy transfer to the emitter and resulting in bright afterglow. The related mechanisms further guided us to achieve the highest reported afterglow luminescence quantum yield of 27.5 %. The system can be encapsulated and dispersed in aqueous solutions for in vivo bioimaging in living mice under mild and simple conditions (low concentration, low excitation power, short excitation time, short exposure time), and also for in vitro diagnostic through lateral flow immunoassay, enabling the highly sensitive detection of the inflammatory biomarker serum amyloid A (SAA) and demonstrating excellent correlation with clinical test results. This study offers new insights into enhancing luminescence QY and brightness of afterglow, highlighting the potential of such systems for further biomedical applications.}, archive = {J_ANGEW}, author = {Yuetian Pei and Yiwei Fan and Kuangshi Sun and Donghao Hu and Yawei Liu and Jiamiao Yin and Lei Chen and Ming Xu and Weigang Yan and Xin Liu and Fuyou Li}, doi = {10.1002/anie.202423791}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423791}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical energy lights up europium-based ultra-bright afterglow for bioanalysis application}, volume = {64}, year = {2025}, }
• (2025). Photochromic color tuning of copper-doped zinc sulfide nanocrystals by control of local dopant environments. ANGEW, 64(15), e202423776. (www)

  @article{ , abstract = {Inorganic photochromic materials offer several advantages over organic compounds, including relatively inexpensive and higher thermal stability. However, tuning their color with the same component has remained a significant challenge. In this study, we demonstrate that the photochromic color of Cu-doped ZnS nanocrystals (NCs), which is initially pale yellow before light irradiation, can be tuned from gray to brown by adjusting the surface stoichiometry of Zn and S, which is controlled through the use of thiol and non-thiol ligands. Several experiments and quantum chemical calculations using model clusters revealed that the color change is determined by the distribution of Cu, which significantly contributes to the coloration, specifically whether it resides on the Zn-rich or S-rich surface. In contrast, particle size and Cu concentration were found to have little effect on the photochromic color. This study expands the diversity of photochromic responses in inorganic NCs and marks an important step toward the development of further advanced photochromic nanomaterials.}, archive = {J_ANGEW}, author = {Mayu Kimura and Daisuke Yoshioka and I-Ya Chang and Akinori Irizawa and Daisuke Shibata and Shin Imada and Yoichi Kobayashi}, doi = {10.1002/anie.202423776}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photochromic color tuning of copper-doped zinc sulfide nanocrystals by control of local dopant environments}, volume = {64}, year = {2025}, }
• (2025). Force-trainable liquid crystal elastomer enabled by mechanophore-induced radical polymerization. ANGEW, 64(15), e202423584. (www)

  @article{ , abstract = {In nature, organisms adapt to environmental changes through training to learn new abilities, offering valuable insights for developing intelligent materials. However, replicating this “adaptive learning” in synthetic materials presents a significant challenge. This study introduces a feasible approach to train liquid crystal elastomers (LCEs) by integrating a mechanophore tetraarylsuccinonitrile into their main chain, addressing the challenge of enabling synthetic materials to exchange substances with their environment. Inspired by biological training, the LCEs can self-strengthen and acquire new functionalities through mechanical stress-induced radical polymerization. The research not only enhances the mechanical performance of LCEs, but also endows them with the ability to learn properties such as flexibility, light responsiveness, and fluorescence. These advancements are crucial for overcoming the limitations of current materials, paving the way for the creation of advanced intelligent soft materials with autonomous self-improvement, akin to the adaptive skills of living organisms.}, archive = {J_ANGEW}, author = {Yiyi Xu and Yinliang Huang and Jinyu Wang and Shuai Huang and Hong Yang and Quan Li}, doi = {10.1002/anie.202423584}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Force-trainable liquid crystal elastomer enabled by mechanophore-induced radical polymerization}, volume = {64}, year = {2025}, }
• (2025). Exceptional battery-level safety of high energy density lithium-ion batteries through non-flammable and low-exothermic localize high concentration electrolytes. ANGEW, 64(15), e202423554. (www)

  @article{ , abstract = {The poor safety performance of high energy density lithium-ion batteries (LIBs) is drawing increasing public concern. To enhance the safety performance on the battery level, it is indispensable to design safe electrolytes that are both non-flammable and low exothermic under abusive conditions. By rational design, a safe localize high concentration electrolyte (LHCE) with non-flammability and extremely low exothermicity is formulated. Compared with conventional LiPF 6 -organocabonate electrolytes and previous LHCEs, the heat generated by the reaction between the safe LHCE and fully charged electrodes under abusive conditions is significantly reduced. Because of the non-flammability and low-exothermicity of the safe LHCE, high energy density LIB (1800 mAh Gr||LiNi 0.7 Mn 0.2 Co 0.1 O 2 , fully charged to 4.3 V) with the safe LHCE successfully passes the nail penetration test. Because of the excellent interphasial properties of the safe LHCE, the cycle life and the rate capability of high energy density LIBs are significantly improved when the safe LHCE is adopted. This work sheds light on the design principles of electrolytes for achieving battery-level safety.}, archive = {J_ANGEW}, author = {Huamin Qiu and Hao Jia and Yifan Zhou and Jun Wang and Wenguang Zhao and Kaiyang Xu and Zimu Li and Shuqin Song and Yi Wang}, doi = {10.1002/anie.202423554}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423554}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exceptional battery-level safety of high energy density lithium-ion batteries through non-flammable and low-exothermic localize high concentration electrolytes}, volume = {64}, year = {2025}, }
• (2025). Synergistic cancer photoimmunotherapy by harnessing near-infrared-activated nanoparticles containing charge transfer complexes. ANGEW, 64(15), e202423550. (www)

  @article{ , abstract = {Phototherapy—which includes photothermal therapy (PTT) and photodynamic therapy (PDT)—has evoked interest as a promising cancer treatment modality on account of its noninvasiveness, spatiotemporal precision, and minimal side effects. C. Wang et al. recently reported a near-infrared-activated charge transfer complex-based nanoparticle which consists of a donor (D) and an acceptor (A). Experimental results have demonstrated a potent immunotherapeutic effect of integrating programmed cell death protein 1 antibody combination therapy in preclinical models. Incorporating D–A interactions into nanosystems for photoimmunotherapy (PIT) is still a novel approach. This approach offers a multifaceted strategy for synergistic cancer PIT which holds promising potential to transform cancer treatment paradigms.}, archive = {J_ANGEW}, author = {Aaron J. Lim and Kade P. Littlefield and Zaid Alkalani and Yuanning Feng}, doi = {10.1002/anie.202423550}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic cancer photoimmunotherapy by harnessing near-infrared-activated nanoparticles containing charge transfer complexes}, volume = {64}, year = {2025}, }
• (2025). Boosting CO2 hydrogenation by synergistic incorporation of pure silica silicalite-1 zeolite and CeO2 into cu catalysts. ANGEW, 64(15), e202423438. (www)

  @article{ , abstract = {Chemical conversion of CO 2 is providing an opportunity to mitigate the global warming induced by the overconsumption of fossil fuel. Cu has been regarded as one of the most powerful contenders in catalyzing CO 2 conversion, yet the precise manipulation of its surface state and the nearby chemical environment continues to pose a formidable challenge. In this work, we report a high-efficiency catalyst by utilizing CeO 2 and pure silicon zeolite (S1) to co-activate Cu species. In CO 2 -to-methanol (CTM) conversion, the space-time yield of methanol (STY MeOH ) of the obtained CuCe/S1 catalysts reaches 87.23 g kg Cu −1 h −1 , which represents a fivefold increase compared to that of the Cu/CeO 2 catalysts. The following mechanistic investigations reveal that S1 serves as a pivotal stabilizer for the small-sized CeO 2 particles, thereby significantly enhancing the synergistic interaction between Cu species and CeO 2 . The crafted interaface possesses abundant oxygen vacancies and a high content of Cu + , significantly enhancing the adsorption of CO 2 and inhibiting the formation of CO. Our discovery presents a promising new direction for catalyst upgrading and performance enhancement for CTM processes in the foreseeable future.}, archive = {J_ANGEW}, author = {Jing Xu and Ke Wang and Meng Zhao and Rui Zhang and Wenjie Cui and Li Liu and Xiao Wang and Jing Wang and Shuyan Song and Hongjie Zhang}, doi = {10.1002/anie.202423438}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423438}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting CO2 hydrogenation by synergistic incorporation of pure silica silicalite-1 zeolite and CeO2 into cu catalysts}, volume = {64}, year = {2025}, }
• (2025). Rational design of cobalt-based prussian blue analogues via 3 d transition metals incorporation for superior na-ion storage. ANGEW, 64(15), e202423356. (www)

  @article{ , abstract = {Understanding the relationship between structure regulation and electrochemical performance is key to developing efficient and sustainable sodium-ion batteries (SIBs) materials. Herein, seven Cobalt-M-based (M=V, Mn, Fe, Co, Ni, Cu, Zn) Prussian blue analogues (CoM-PBAs) are designed as anodes for SIBs via a universal low-energy co-precipitation approach with the strategic inclusion of 3d transition metals. Density Functional Theory (DFT) simulation and experimental validation reveal that a moderate p -band center of cyanide linkages (−CN−) is more favorable for Na + intercalation and diffusion, while the d -band center of metal cations is linearly related to electrode stability. Among seven CoM-based PBAs, CoV-PBAs possess the best sodium-ion adsorption/diffusion kinetics and overall cycling performance, including high specific capacity (565 mAh/g at 0.1 A/g), cycling stability (over 15000 cycles with 97.7 % capacity retention), and superior rate capability (174.7 mAh/g at 30 A/g). In situ / ex situ techniques further demonstrate that the π-electron regulation by V introduction enhances the reversibility and kinetics of redox reactions. Moreover, the study identified the “ p -band center” and “ d -band center” may serve as key descriptors for quantifying the capability and stability of other-type bimetal Co-based anodes (oxides, phosphides, sulfides, and selenides) with similar theoretical capacity, offering a potentially transformative approach for selecting practical SIB electrode materials.}, archive = {J_ANGEW}, author = {Zhongxin Jing and Muhammad Mamoor and Lingtong Kong and Lu Wang and Bin Wang and Ming Chen and Fengbo Wang and Guangmeng Qu and Yueyue Kong and Dedong Wang and Xiyu He and Chang Wang and Xintong Zhang and Yufei Zhang and Gang Wang and Liqiang Xu}, doi = {10.1002/anie.202423356}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423356}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design of cobalt-based prussian blue analogues via 3 d transition metals incorporation for superior na-ion storage}, volume = {64}, year = {2025}, }
• (2025). Activatable photosensitizers: From fundamental principles to advanced designs. ANGEW, 64(15), e202423348. (www)

  @article{ , abstract = {Photodynamic therapy (PDT) is a promising treatment that uses light to excite photosensitizers in target tissue, producing reactive oxygen species and localized cell death. It is recognized as a minimally invasive, clinically approved cancer therapy with additional preclinical applications in arthritis, atherosclerosis, and infection control. A hallmark of ideal PDT is delivering disease-specific cytotoxicity while sparing healthy tissue. However, conventional photosensitizers often suffer from non-specific photoactivation, causing off-target toxicity. Activatable photosensitizers (aPS) have emerged as more precise alternatives, offering controlled activation. Unlike traditional photosensitizers, they remain inert and photoinactive during circulation and off-target accumulation, minimizing collateral damage. These photosensitizers are designed to “turn on” in response to disease-specific biostimuli, enhancing therapeutic selectivity and reducing off-target effects. This review explores the principles of aPS, including quenching mechanisms stemming from activatable fluorescent probes and applied to activatable photosensitizers (RET, PeT, ICT, ACQ, AIE), as well as pathological biostimuli (pH, enzymes, redox conditions, cellular internalization), and bioresponsive constructs enabling quenching and activation. We also provide a critical assessment of unresolved challenges in aPS development, including limitations in targeting precision, selectivity under real-world conditions, and potential solutions to persistent issues (dual-lock, targeting moieties, biorthogonal chemistry and artificial receptors). Additionally, it provides an in-depth discussion of essential research design considerations needed to develop translationally relevant aPS with improved therapeutic outcomes and specificity.}, archive = {J_ANGEW}, author = {Nahyun Kwon and Hanyi Weng and Maneesha A. Rajora and Gang Zheng}, doi = {10.1002/anie.202423348}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activatable photosensitizers: From fundamental principles to advanced designs}, volume = {64}, year = {2025}, }
• (2025). Reaction of NHOs with bisphosphanes – Designing diradicaloids, zwitterions and radicals. ANGEW, 64(15), e202423347. (www)

  @article{ , abstract = {The linkage of an imidazole-based N -heterocyclic olefin (NHO), containing a terminal CH 2 donor group, with a phosphorus-centered diradical molecular fragment leads to an open-shell singlet diphospha-indenylide system, a new class of P -heterocycles, which can be interpreted both as a phosphorus-centered diradicaloid and as a zwitterion with a permanent, overall charge separation between the N - and P -heterocyclic ring systems. The rotation of the imidazole ring, which is thermally possible due to a central C−C bond with a weakened π-component, changes both the charge separation and diradical character depending on the dihedral angle, as quantum mechanical calculations indicate. By varying the bulkiness of substituents at the imidazole-based NHO, it was possible to obtain different diphospha-indenylide species with different rotation angles in the solid state and hence varying diradical character. Imidazolium-diphospha-indenylides represent a new class of NHO-based zwitterions with diradical character. Their synthesis, structure, and activation chemistry are described, as well as the quantum mechanical description of the electronic structure in these unusual heterocycles. In addition, along the synthesis route to diphospha-indenylide, we also succeeded in isolating a highly reactive monoradical anion, which was also fully characterized.}, archive = {J_ANGEW}, author = {Karsten Paul Lüdtke and Edgar Zander and Florian Taube and Jan-Erik Siewert and Björn Corzilius and Christian Hering-Junghans and Jonas Bresien and Axel Schulz}, doi = {10.1002/anie.202423347}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423347}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reaction of NHOs with bisphosphanes – Designing diradicaloids, zwitterions and radicals}, volume = {64}, year = {2025}, }
• (2025). Liquid metal nanobiohybrids for high-performance solar-driven methanogenesis via multi-interface engineering. ANGEW, 64(15), e202423336. (www)

  @article{ , abstract = {Nanobiohybrids for solar-driven methanogenesis present a promising solution to the global energy crisis. However, conventional semiconductor-based nanobiohybrids face challenges such as limited tunability and poor biocompatibility, leading to undesirable spontaneous electron and proton transfer that compromise their structural stability and CH 4 selectivity. Herein, we introduced eutectic gallium–indium alloys (EGaIn), featuring a self-limiting surface oxide layer surrounding the liquid metal core after sonication, integrated with Methanosarcina barkeri ( M. b ). The well-designed M. b –EGaIn nanobiohybrids exhibited superior performance, achieving a maximum CH 4 yield of 455.64±15.99 μmol g −1 , long-term stability across four successive 7-day cycles, and remarkable CH 4 selectivity of >99 %. These improvements stem from enhanced proton-coupled electron transfer involving hydrogen atoms at the core–shell interface, further facilitated by the elevated expression of hydrogenases at the abiotic–biotic interface. This study provides an insightful concept for nanobiohybrid design through multi-interface engineering, advancing sustainable and scalable CO 2 -to-biofuel conversion under ambient conditions.}, archive = {J_ANGEW}, author = {Wenzhi Gu and Jing Hu and Lei Li and Mingqiu Hong and Dong Zhang and Jiajing Chen and Jie Ye and Shungui Zhou}, doi = {10.1002/anie.202423336}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423336}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Liquid metal nanobiohybrids for high-performance solar-driven methanogenesis via multi-interface engineering}, volume = {64}, year = {2025}, }
• (2025). Monitoring the fate of zn in the Cu/ZnO/ZrO2 catalyst during CO2-to-methanol synthesis at high conversions by operando spectroscopy. ANGEW, 64(15), e202423281. (www)

  @article{ , abstract = {In the frame of developing a sustainable chemical industry, heterogeneously catalyzed CO 2 hydrogenation to methanol has attracted considerable interest. However, the Cu−Zn based catalyst system employed in this process is very dynamic, especially in the presence of the products methanol and water. Deactivation needs to be prevented, but its origin and mechanism are hardly investigated at high conversion where product condensation is possible. Here, we report on the structural dynamics of a Cu/ZnO/ZrO 2 catalyst at 90 bar and 40 % CO 2 conversion (at equilibrium conditions), investigated in a dedicated metal-based spectroscopic cell specially fabricated using additive manufacturing. This particular reactor configuration aims to mimic the high CO 2 conversion part of the catalyst bed and can induce product condensation, which is monitored by operando X-ray absorption spectroscopy. While Cu remained mostly stable throughout the experiment, Zn underwent strong restructuring. The chosen reaction conditions, including the use of CO 2 as carbon source and in situ product condensation, were selected to provide insights under industrial conditions. This work is highlighting the importance of spectroscopic investigations at high conversion levels, offering insights into chemical transformations during deactivation, extending the concept of spatially resolved studies, and thus providing guidance for the design of more stable catalysts.}, archive = {J_ANGEW}, author = {Mariam L. Schulte and Vera Truttmann and Dmitry E. Doronkin and Lorena Baumgarten and Alexander Nicolai and Diego Alejandro Montalvo Beltran and Florian J. Summ and Christoph Kiener and Lucas Warmuth and Stephan Pitter and Erisa Saraçi and Jan-Dierk Grunwaldt}, doi = {10.1002/anie.202423281}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423281}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Monitoring the fate of zn in the Cu/ZnO/ZrO2 catalyst during CO2-to-methanol synthesis at high conversions by operando spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Surface hydroxylated S/O dual-vacancy S-scheme hollow [In2S3-x/In2O3-x](OH)y heterojunction for photothermal-promoted low-temperature Methanol/Water reforming into hydrogen. ANGEW, 64(15), e202423269. (www)

  @article{ , abstract = {To enable highly efficient in situ hydrogen release from methanol/water reforming at lower temperature, the integration of solar-energy offers a promising approach to activate methanol/water and substantially lower the activation energy of this reaction. Herein, we present a novel dual-vacancy defective hollow heterostructure derived from Metal–Organic Frameworks, featuring abundant surface hydroxyl groups and S/O vacancies, for photothermal-promoted methanol solution reforming into hydrogen. The [In 2 S 3-x /In 2 O 3-x ](OH) y exhibits exceptional photothermal H 2 evolution activity, achieving a production rate of 215.2 mmolg cat −1 h −1 , 16-fold higher than its thermocatalytic activity, with an apparent quantum efficiency of 66.8 % at 365 nm and solar-to-hydrogen efficiency (STH) of 1.1 % under AM 1.5G simulated solar illumination, and excellent durability over 82 h, cumulating 2.61×10 3 mmolg cat −1 . The synergistic effects of dual-vacancies and the hollow heterostructure significantly enhance the photothermal effect, lowering the activation energy barrier for methanol/water, enabling H 2 production at temperatures even as 80 °C under non-alkaline conditions. Furthermore, the incorporated surface hydroxyl groups facilitate the generation of active surface hydroxyls from water, further driving activation and cleavage of C−H bonds in methanol, thereby markedly reducing the apparent reaction activation energy by 12.5 %. This work provides a new strategy for effective H 2 production from aqueous methanol reforming under mild conditions, holding great promise for energy-demanding industrial applications.}, archive = {J_ANGEW}, author = {Yunhong Pi and Wenting Lin and Jianxian Li and Jingyao Yang and Ziyu Zengcai and Quanming Chen and Juan Guo and Tiejun Wang}, doi = {10.1002/anie.202423269}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface hydroxylated S/O dual-vacancy S-scheme hollow [In2S3-x/In2O3-x](OH)y heterojunction for photothermal-promoted low-temperature Methanol/Water reforming into hydrogen}, volume = {64}, year = {2025}, }
• (2025). Inhibiting interfacial electron leakage via an artificial rectified layer for longevous zinc metal anodes. ANGEW, 64(15), e202423244. (www)

  @article{ , abstract = {Dendrites and water-induced side reactions impose greatly challenge on the implementation of aqueous zinc ion batteries. To tackle these problems, an artificial rectified layer (ARL) with hydrophobic, zincophilic and insulating features was in situ synthesized on Zn surface rapidly to prevent the electron leakage from Zn anode to aqueous electrolyte, which is the underlying logic for uneven Zn deposition and parasitic side reactions. The ARL also displays a high Zn 2+ transference number of 0.71 and can build fast Zn 2+ transport channels to homogenize the interfacial ion flux and electric field according to the calculated work function and multi-physics phase simulation results. Therefore, the Zn anode with ARL shows preferred plating along with (002) crystal facet and an admirable Coulombic efficiency of 99.86 % over 3200 cycles. Zn symmetric cells can withstand large current density up to 40 mA cm −2 and operate stably at 44.2 % depth of discharge for 250 hours, surpassing most of published reports. The ARL also enables the Zn||MnO 2 full batteries to circulate over 2600 cycles with a high-capacity retention of 80.1 % and low self-discharge at 1 A g −1 . This work provides a different perspective to comprehend and design satisfactory solid electrolyte interphase for Zn metal anodes.}, archive = {J_ANGEW}, author = {Guang-Yuan Yin and Hong-Rui Wang and Min-Yang Zhou and Tao Long and Meng-Sha Ding and Bin Xie and Xiong-Wei Wu and Jiabao Li and Wei Ling and Jiayu Dai and Xian-Xiang Zeng}, doi = {10.1002/anie.202423244}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423244}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inhibiting interfacial electron leakage via an artificial rectified layer for longevous zinc metal anodes}, volume = {64}, year = {2025}, }
• (2025). Sabatier principle inspired bifunctional alloy interface for stable and high-depth discharging zinc metal anodes. ANGEW, 64(15), e202423236. (www)

  @article{ , abstract = {Achieving stable Zn anodes that can effectively couple with Zn-free cathodes is essential for advancing high-performance Zn metal batteries. Here, we propose a Sabatier principle inspired bifunctional transition-metal (TM) interface to enable homogeneous Zn dissolution during discharging and dendrite-free Zn deposition during charging. Among various TM-coated Zn (TM@Zn) electrodes, Cu@Zn exhibits the highest reversibility and structural stability, attributed to the optimal interaction between Cu and Zn. The heteroatomic interaction-dependent electrochemical performance parallels the Sabatier principle. Morphological analyses reveal that bare Zn anodes display detrimental etching pits during stripping, which is different from the uniform dissolution for Cu@Zn electrodes. During subsequent plating, the conductive interface serves as a secondary current collector for uniform Zn deposition in Cu@Zn, thus demonstrating a bifunctional nature. Atomic observations disclose the working mechanisms of this interface as a gradual phase transition from Cu to CuZn 5 during cycling. The Cu@Zn anodes exhibit an ultralong cycling lifespan of over 8000 h at a low current of 1 mA cm −2 and over 250 h at a high depth of discharge of 80 %. They also demonstrate practical feasibility by maintaining 88.7 % capacity retention after 1000 cycles in Cu@Zn||VO 2 full cells. This work provides new insights into the Sabatier chemistry inspired bifunctional layers for Zn metal battery system.}, archive = {J_ANGEW}, author = {Jingya Yu and Zizheng Song and Qi Qi and Xiaobin Hui and Yiyuan Ma and Feiyang Chen and Kai Qi and Qi Meng and Renjie Li and Lyuchao Zhuang and Kang Cheung Chan and Zibin Chen and Bao Yu Xia and Zheng-Long Xu}, doi = {10.1002/anie.202423236}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423236}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sabatier principle inspired bifunctional alloy interface for stable and high-depth discharging zinc metal anodes}, volume = {64}, year = {2025}, }
• (2025). High-performance overall water splitting dominated by direct ligand-to-cluster photoexcitation in Metal–Organic frameworks. ANGEW, 64(15), e202423070. (www)

  @article{ , abstract = {Expanding the spectral response of photocatalysts to facilitate overall water splitting (OWS) represents an effective approach for improving solar spectrum utilization efficiency. However, the majority of single-phase photocatalysts designed for OWS primarily respond to the ultraviolet region, which accounts for a small proportion of sunlight. Herein, we present a versatile strategy to achieve broad visible-light-responsive OWS photocatalysis dominated by direct ligand-to-cluster charge transfer (LCCT) within metal–organic frameworks (MOFs). Three synthesized OWS MOFs, namely Fe 2 MCbz (M 2+ = Mn 2+ , Co 2+ , Ni 2+ ), exhibited intrinsic OWS capability without the requirement for extra photosensitizer or sacrificial agent or cocatalyst. Among these, Fe 2 NiCbz was identified as the superior performer, and when dispersed with polyacrylonitrile nanofibers using electrospinning technology, it achieved the highest OWS rates of 170.2 and 85.1 μmol g −1 h −1 for H 2 and O 2 evolution, surpassing all previously documented MOF-based photocatalysts. Experimental and theoretical analyses revealed that direct LCCT played a crucial role in enhancing the photocatalytic efficiency, with exceptional performance of Fe 2 NiCbz attributed to its well-optimized energy level structures and highly efficient charge transfer mechanism. This work not only sets a benchmark in OWS MOF photocatalysts but also paves the way for maximizing solar spectrum utilization, thereby advancing renewable hydrogen production strategy.}, archive = {J_ANGEW}, author = {Qia-Chun Lin and Wei-Ming Liao and Jiayu Li and Bowei Ye and Da-Tang Chen and Xiao-Xiang Zhou and Peng-Hui Li and Meng Li and Ming-De Li and Jun He}, doi = {10.1002/anie.202423070}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance overall water splitting dominated by direct ligand-to-cluster photoexcitation in Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Logic-gated DNA intelligent nanorobots for cellular lysosome interference and enhanced therapeutics. ANGEW, 64(15), e202423004. (www)

  @article{ , abstract = {Environment-recognizing DNA nanodevices have proven promising for cellular manipulation and disease treatment, whereas how to sequentially respond to different cellular microenvironments remains a challenge. To this end, here we elaborate a logic-gated intelligent DNA nanorobot (Gi-DR) for the cascade response to inter- and intra-cellular microenvironments, thereby achieving lysosome-targeted cargo delivery for subcellular interference and tumor treatment with enhanced efficacy. Utilizing G-quadruplexes to respond to high-level K + in cancer cell surrounding, this Gi-DR nanorobot can activate an aptamer-based transmembrane DNA machine that delivers molecular payloads to cellular lysosome. Accordingly, the nanoassembly of Gi-DR is promoted by the folding of heterodimeric i-motifs in the acidic microenvironment. Such a design allows the extra-/intra-cellular behaviors of the Gi-DR nanorobot to be programmed by an YES-AND logic circuit, with environmental K + and H + as two inputs. As a consequence, DNA nanostrips are controllably formed in living cells, interfering with lysosomal function and thereby preventing cellular proliferation. Further, a therapeutic agent (i.e. ligand-drug conjugate) is delivered into target cancer cells for synergistic tumor treatment in vivo, exhibiting the super-enhanced cancer cell lethality and anti-tumor efficacy. It well illustrates that our designed logic-gated DNA nanorobot has broad application prospects in modulating cellular function and precision disease treatment.}, archive = {J_ANGEW}, author = {Qiwei Wang and Ruixue Chang and Xiuping Li and Ying Zhang and Xiangshan Fan and Lili Shi and Tao Li}, doi = {10.1002/anie.202423004}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202423004}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Logic-gated DNA intelligent nanorobots for cellular lysosome interference and enhanced therapeutics}, volume = {64}, year = {2025}, }
• (2025). Ligand-directed actinide oxo-bond manipulation in actinyl thiacalix[4]arene complexes. ANGEW, 64(15), e202422974. (www)

  @article{ , abstract = {Understanding the chemistry of the inert actinide oxo bond in actinyl ions AnO 2 2+ is important for controlling actinide behavior in the environment, during separations, and in nuclear waste (An=U, Np, Pu). The thioether calixarene TC4A (4- tert -butyltetrathiacalix[4]arene) binds equatorially to the actinyl cation forming a conical pocket that differentiates the two trans- oxo groups. The ‘ate’ complexes, [A] 2 [UO 2 (TC4A)] (A=[Li(DME) 2 ], HNEt 3 ) and [HNEt 3 ] 2 [AnO 2 (TC4A)] (An=U, Np, Pu), enable selective oxo chemistry. Silylation of the U VI oxo groups by bis(trimethylsilyl)pyrazine occurs first at only the unencapsulated exo oxo and only one silylation is needed to enable migration of the endo oxo out of the cone, whereupon a second silylation affords the stable U IV cis- bis(siloxide) [A] 2 [U(OSiMe 3 ) 2 (TC4A)]. Calculations confirm that only one silylation event is needed to initiate oxo rearrangement, and that the putative cis dioxo isomer of [UO 2 (TC4A)] 2− would be stable if it could be accessed synthetically, at only 23 kcal.mol −1 in energy above the classical trans dioxo. Calculations for the transuranic cis [AnO 2 (TC4A)] 2− (An=Np, Pu) are at higher energies, 30–35 kcal.mol −1 , retaining the U complexes as the more obvious target for a cis -dioxo actinyl ion. The aryloxide (OAr) groups of the macrocycle are essential in stabilizing this as-yet unseen uranyl geometry as further bonding in the TC4A U-O Ar groups stabilizes the U=O ‘yl’ bonds, explaining the stability of the putative cis [UO 2 (TC4A)] 2− in this ligand framework.}, archive = {J_ANGEW}, author = {Mikaela M. Pyrch and Rachel L. Meyer and Thayalan Rajeshkumar and Piper A. Cooke and David J. Fiszbein and Emi Ito and Nicholas J. Katzer and Cambell S. Conour and Stefan G. Minasian and Laurent Maron and Polly L. Arnold.}, doi = {10.1002/anie.202422974}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422974}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-directed actinide oxo-bond manipulation in actinyl thiacalix[4]arene complexes}, volume = {64}, year = {2025}, }
• (2025). Steady state free precession NMR without fourier transform: Redefining the capabilities of 19F NMR as a discovery tool. ANGEW, 64(15), e202422971. (www)

  @article{ , abstract = {The 2024 Zurich perfluorinated compounds (PFCs) summit reiterated the urgent need for non-selective analytical approaches for PFC detection. 19 F NMR holds great potential, however, sensitivity limitations lead to long analysis times and/or the possibility of not detecting low concentration species. Steady State Free Precession (SSFP) NMR collects the signal in a steady state regime, allowing 100’s of acquisitions in the timespan of a single traditional NMR scan. Unfortunately, data truncation from SSFP leads to artifacts and spectral broadening with Fourier transform, hindering interpretation. When non-Fourier based time-domain analysis is used, namely, complete reduction to amplitude frequency tables (CRAFT), limitations of SSFP are eliminated while sensitivity gains are retained. This work introduces the combined approach, then applies it for the measurement of PFCs in environmental and biological samples. In all cases, the approach reduces analysis time from many hours to minutes and/or greatly increases the range of compounds detected. For example, when PFOA was spiked into human blood, the detection limit improved ~50-fold vs standard NMR, while in a standard mixture, the approach detected compounds missed by LC-MS/MS. The technique can be adapted to any nucleus providing a facile approach to reduce experiment time and improve sensitivity of NMR in general.}, archive = {J_ANGEW}, author = {Jeremy R. Gauthier and Flavio Kock and Katelyn Downey and Tiago Moraes and Luísa Souza Almeida and Derek C. G. Muir and Robert J. Letcher and Luiz Colnago and Krish Krishnamurthy and Scott Mabury and Andre J. Simpson}, doi = {10.1002/anie.202422971}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422971}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Steady state free precession NMR without fourier transform: Redefining the capabilities of 19F NMR as a discovery tool}, volume = {64}, year = {2025}, }
• (2025). Direct CO2 activation and conversion to ethanol via reactive oxygen species. ANGEW, 64(15), e202422967. (www)

  @article{ , abstract = {The growing demand for energy and the excessive use of fossil fuels represents one of the main challenges for humanity. Storing solar energy in the form of chemical bonds to generate solar fuels or value-added chemicals without creating additional environmental burdens is a key requirement for a sustainable future. Here we use biomimetic artificial photosynthesis and present a dPCN-224(H) MOF-based photocatalytic system, which uses reactive oxygen species (ROS) to activate and convert CO 2 to ethanol under atmospheric conditions, at room temperature and in 2–5 h reaction time. The system provides a CO 2 -to-ethanol conversion efficiency (CTE) of 92 %. Furthermore, this method also allows the conversion of CO 2 through direct air capture (DAC), making it a rapid and versatile method for both dissolved and gaseous CO 2 .}, archive = {J_ANGEW}, author = {Alina Meindl and Daniel Heffernan and Jürgen Kudermann and Nicole Strittmatter and Mathias O. Senge}, doi = {10.1002/anie.202422967}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422967}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct CO2 activation and conversion to ethanol via reactive oxygen species}, volume = {64}, year = {2025}, }
• (2025). Tailoring the surface curvature of the supporting carbon to tune the d-band center of Fe−N−C single-atom catalysts for zinc-urea-air batteries. ANGEW, 64(15), e202422920. (www)

  @article{ , abstract = {The catalytic activities of the Fe−N−C single-atom catalysts (SACs) are associated with the varying atomic interactions through its characteristic coordination geometry. Yet, modulation of the surface curvature of carbon acting as a supporting body has not been investigated. Herein, we report the superior catalytic activity for the oxygen reduction reaction (ORR) and enhanced performance for urea oxidation reaction (UOR) of single Fe atoms anchored on a highly curved N-doped carbon dodecahedron with concave morphology (Fe SA/NhcC). Theoretical calculations and in situ spectroscopy disclose that the curvature of the carbon support helps to shorten the bond length of Fe−N, spatially redistributing the charges around the Fe and thereby lowering the d-band center toward optimal adsorption for oxygenated species. The Fe SA/NhcC catalyst displays an ultrahigh half-wave potential of 0.926 V for ORR and a small potential difference of 0.686 V for bifunctional ORR/UOR. A rechargeable Zn-urea-air battery with the Fe SA/NhcC cathode displays robust discharge durability, excellent cycling lifespan and higher energy efficiency compared to conventional Zn-air batteries. This work provides new insight into promoting the catalytic activity of SACs through varying the surface curvature of the supporting carbon, tailoring geometric configuration and electronic states of SACs.}, archive = {J_ANGEW}, author = {Qichen Wang and Lulu Lyu and Xu Hu and Wenqi Fan and Chunyan Shang and Qirui Huang and Zhipeng Li and Zhen Zhou and Yong-Mook Kang}, doi = {10.1002/anie.202422920}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422920}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring the surface curvature of the supporting carbon to tune the d-band center of Fe−N−C single-atom catalysts for zinc-urea-air batteries}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of the tridecasaccharide motif from angelica sinensis APS-1 II polysaccharide with anti-leukemia activity and structure-activity relationship studies. ANGEW, 64(15), e202422887. (www)

  @article{ , abstract = {A polysaccharide APS-1 II from a medicinal plant Angelica sinensis (Oliv.) Diels represents a potential therapeutic agent against leukemia. However, the synthetic accessibility of the highly branched and complex APS-1 II polysaccharide with multiple 1, 2- cis -glycosidic linkages remains a difficult task, impeding the in-depth structure–activity relationship biological studies and the development of carbohydrates-based therapeutics against leukemia. Here, we report the first chemical synthesis of tridecasaccharide repeating unit together with shorter sequences 4-mer, 6-mer and 9-mer from APS-1 II polysaccharide via one-pot orthogonal glycosylation strategy based on glycosyl ortho -(1-phenylvinyl)benzoates, which precluded the potential issues such as aglycone transfer associated with one-pot assembly with thioglycosides. The synthetic pathway also features the following aspects: 1) three contiguous and challenging 1, 2- cis -Fuc bonds were highly stereoselectively constructed via the newly developed stereoselective 1, 2- cis -fucosylation method; 2) several 1, 2- trans -glycosidic linkages were formed via neighboring group participation effect, while 1,2- cis -Glc linkage was stereoselectively assembled via N , N -dimethylformamide reagent modulation; 3) the final [1+1+2+9] one-pot assembly of the target tridecasaccharide via strategic utilizations of glycosyl N -phenyltrifluoroacetimidates, ortho -alkynylbenzoates and ortho -(1-phenylvinyl)benzoates. Biological studies revealed that human leukemia K562 and mouse L1210 cells could be effectively inhibited by tridecasaccharide repeating unit and substructure nonasaccharide.}, archive = {J_ANGEW}, author = {Fuqiang Guo and Qiang Tan and Jiahui Guo and Kaifeng Li and Xiufang Wang and Wei Cao and Guozhi Xiao}, doi = {10.1002/anie.202422887}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422887}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of the tridecasaccharide motif from angelica sinensis APS-1 II polysaccharide with anti-leukemia activity and structure-activity relationship studies}, volume = {64}, year = {2025}, }
• (2025). A “Flexible” solvent molecule enabling high-performance lithium metal batteries. ANGEW, 64(15), e202422791. (www)

  @article{ , abstract = {Electrolyte chemistries are crucial for achieving high cycling performance and high energy density in lithium metal batteries. The localized high-concentration electrolytes (LHCEs) exhibit good performance in lithium metal batteries. However, understanding how the intermolecular interactions between solvents and diluents in the electrolyte regulate the solvation structure and interfacial layer structure remains limited. Here, we reported a new LHCE in which strong hydrogen bonding between diluents and solvents alters the conformation and polarity of “flexible” solvent molecules, thereby effectively regulating the solvation structure of Li + ion and promoting the formation of robust electrode interfaces. The endpoint H of the “flexible” chain O-CH-CH 3 of the 2,5-dimethyltetrahydrofuran (2,5-THF) solvent and the F of the benzotrifluoride (BTF) diluent can form strong hydrogen bonds, which expand the maximum bond angle of the 2,5-THF molecule from 119° to 123°. The expanded bond angle increases the steric hindrance of the 2,5-THF molecule and decreases its polarity. This leads to an increase in the anion content within the solvation structure, which in turn enhances the performance of both the lithium metal anode and the sulfurized polyacrylonitrile (SPAN) cathode. As a result, the lithium metal anode shows a Coulombic efficiency (CE) of as high as 99.4 %. The assembled Li||SPAN battery based on our developed LHCE exhibits impressive stability with an average CE of 99.8 % over 700 cycles. Moreover, the Li||SPAN pouch cell can be stably cycled with a high energy density of 301.4 Wh kg −1 . This molecular-level understanding of the correlation between molecular interactions and solvation structures provides new insights into the design of advanced LHCEs for high-performance lithium metal batteries.}, archive = {J_ANGEW}, author = {Lu Chen and Qing Zhang and Chunlei Song and Yanxin Jiang and Xitong Sheng and Hongji Pan and Liu Yang and Shumin Wu and Lin Zeng and Delong Sun and Chong Wang and Tianshuai Wang and Yiju Li and Tianshou Zhao}, doi = {10.1002/anie.202422791}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422791}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A “Flexible” solvent molecule enabling high-performance lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Low temperature atomic layer deposition of (00l)-oriented elemental bismuth. ANGEW, 64(15), e202422578. (www)

  @article{ , abstract = {This study presents the first successful demonstration of growing elemental bismuth (Bi) thin films via thermal atomic layer deposition (ALD) using Bi(NMe 2 ) 3 as the precursor and Sb(SiMe 3 ) 3 as the co-reactant. The films were deposited at a relatively low temperature of 100 °C, with a growth per cycle (GPC) of 0.31–0.34 Å/cycle. Island formation marked the initial growth stages, with surface coverage reaching around 80 % after 1000 cycles and full coverage between 2000 and 2500 cycles. Morphological analysis revealed that the Bi grains expanded and became more defined as the number of ALD cycles increased. This coalescence is further supported by X-ray diffraction (XRD) patterns, which show a preferential shift in growth orientation from the (012) plane to the (003) plane as the film thickness increases. X-ray photoemission spectroscopy (XPS) confirmed the presence of metallic Bi with minimal surface oxidation. Temperature-dependent sheet resistance measurements highlight the semimetallic nature of Bi, with a room temperature resistivity of ≈200 μΩcm for the 2500 cycles Bi. Temperature-dependent sheet resistance was also associated with a transition in carrier-type dominance from holes at higher temperatures to electrones at lower temperatures.}, archive = {J_ANGEW}, author = {Jorge Luis Vazquez-Arce and Alessio Amoroso and Nicolas Perez and Jaroslav Charvot and Dominik Naglav-Hansen and Panpan Zhao and Jun Yang and Sebastian Lehmann and Angelika Wrzesińska-Lashkova and Fabian Pieck and Ralf Tonner-Zech and Filip Bureš and Annalisa Acquesta and Yana Vaynzof and Anjana Devi and Kornelius Nielsch and Amin Bahrami}, doi = {10.1002/anie.202422578}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low temperature atomic layer deposition of (00l)-oriented elemental bismuth}, volume = {64}, year = {2025}, }
• (2025). Targeted docking of localized hydrogen bond for efficient and reversible zinc-ion batteries. ANGEW, 64(15), e202422547. (www)

  @article{ , abstract = {Hydrogen bond (HB) chemistry, a pivotal feature of aqueous zinc-ion batteries, modulates electrochemical processes through weak electrostatic interactions among water molecules. However, significant challenges persist, including sluggish desolvation kinetics and inescapable parasitic reactions at the electrolyte-electrode interface, associated with high water activity and strong Zn 2+ -solvent coordination. Herein, a targeted localized HB docking mechanism is activated by the polyhydroxy hexitol-based electrolyte, optimizing Zn 2+ solvation structures via dipole interaction and reconstructing interfacial HB networks through preferential parallel adsorption. By combining in situ spectroscopic characterizations with theoretical calculations, we elucidate the dynamic evolution of localized HB networks, which enhance Zn 2+ deposition kinetics and homogeneity, suppress water-induced side reactions, and mitigate vanadium framework collapse. Our findings support that the targeted HB docking strategy facilitates fast interfacial ion transport kinetics and enables high reversibility, with a substantially prolonged symmetric cell lifespan exceeding 5000 h. This work markedly advances the efficient and reversible zinc-based batteries.}, archive = {J_ANGEW}, author = {Pinji Wang and Tian Chen Li and Yanfen Liu and Congjian Lin and Yangfeng Cui and Haobin Song and Bingan Lu and Shuquan Liang and Hui Ying Yang and Jiang Zhou}, doi = {10.1002/anie.202422547}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422547}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Targeted docking of localized hydrogen bond for efficient and reversible zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Catalytic amino group transfer reactions mediated by photoinduced nitrene formation from rhodium-hydroxamates. ANGEW, 64(15), e202422461. (www)

  @article{ , abstract = {Herein, we report a photocatalytic platform to access transient nitrenoids by designing photo-responsive neutral rhodium-hydroxamate complexes. Combined experimental and computational mechanistic studies, including electron paramagnetic resonance (EPR) and mass spectrometric analysis, suggest that electrophilic Fischer-type Rh-acylnitrenoid intermediates could be generated via photoactivation of corresponding Rh-hydroxamates via N-O bond homolysis and redox event. Moreover, catalytic acylnitrenoid transfer was explored toward the amidation of various hydrocarbons, amines, and alcohols to furnish new N−C, N−N, and N−O bonds.}, archive = {J_ANGEW}, author = {Hoimin Jung and Jeonguk Kweon and Jong-Min Suh and Andrés Arribas and Dongwook Kim and Mi Hee Lim and Sukbok Chang}, doi = {10.1002/anie.202422461}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic amino group transfer reactions mediated by photoinduced nitrene formation from rhodium-hydroxamates}, volume = {64}, year = {2025}, }
• (2025). Abstraction of hydride from alkanes and dihydrogen by the perfluorotrityl cation. ANGEW, 64(15), e202422190. (www)

  @article{ , abstract = {Lewis acids play a central role in a large variety of chemical transformations. The reactivity of the strongest Lewis acids is typically studied in the context of affinity towards hard bases, such as fluoride or oxygenous species. Carbocations can be viewed as soft Lewis acids, possessing significant affinity for softer bases, such as hydride. This work presents the ambient-temperature isolation of salts of the perfluorotrityl cation ((C 6 F 5 ) 3 C + or F 15 Tr + ) in combination with halogenated carborane anions. The F 15 Tr + cation exhibits remarkable hydride affinity, illustrated by the observation of hydride abstraction from dihydrogen, and of the rapid abstraction of hydride from −CH 2 −groups in alkanes. Theoretical studies support the favorability of hydride abstraction from dihydrogen, and indicate that the hydride abstraction from alkanes proceeds via a concerted hydride transfer process that is sensitive to steric effects.}, archive = {J_ANGEW}, author = {Derek W. Leong and Achyut R. Gogoi and Tapas Maity and Chun-I Lee and Nattamai Bhuvanesh and Osvaldo Gutierrez and Oleg V. Ozerov}, doi = {10.1002/anie.202422190}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Abstraction of hydride from alkanes and dihydrogen by the perfluorotrityl cation}, volume = {64}, year = {2025}, }
• (2025). Promiscuity guided evolution of decarboxylative aldolases for synthesis of tertiary γ-hydroxy amino acids. ANGEW, 64(15), e202422109. (www)

  @article{ , abstract = {Many applications of enzymes benefit from activity on structurally diverse substrates. Here, we sought to engineer the decarboxylative aldolase UstD to perform a challenging C−C bond forming reaction with ketone electrophiles. The parent enzyme had only low levels of activity, portending multiple rounds of directed evolution and a possibility that mutations may inadvertently increase the specificity of the enzyme for a single model screening substrate. We show how to intentionally guide UstD towards generality through multi-generational directed evolution using substrate-multiplexed screening (SUMS). Mutations outside of the active site that impact catalytic function were immediately revealed by shifts in promiscuity, even when the overall activity was lower. By re-targeting these distal residues that couple to the active site with saturation mutagenesis, broadly activating mutations were readily identified. When analyzing active site mutants, SUMS identified both specialist enzymes that would have more limited utility as well as generalist enzymes with complementary activity on diverse substrates. These new UstD enzymes catalyze convergent synthesis of non-canonical amino acids bearing tertiary alcohol side chains. This methodology is easy to implement and enables the rapid and effective evolution of enzymes to catalyze desirable new functions.}, archive = {J_ANGEW}, author = {Meghan E. Campbell and Amanda R. Ohler and Matthew J. McGill and Andrew R. Buller}, doi = {10.1002/anie.202422109}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422109}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promiscuity guided evolution of decarboxylative aldolases for synthesis of tertiary γ-hydroxy amino acids}, volume = {64}, year = {2025}, }
• (2025). Valence state hydrogen channel enhances sustained and controllable electrocatalytic hydrogen evolution in diabetic skin wound healing. ANGEW, 64(15), e202422091. (www)

  @article{ , abstract = {Diabetes significantly increases the risk of serious health issues, including prolonged skin inflammation and delayed wound healing, owing to inferior glucose control and suppression of the immune system. Although traditional hydrogen (H 2 ) therapy is slightly effective, its ability to tailor the release of H 2 on the skin is limited. Accordingly, this study proposed a novel strategy for electrocatalytic H 2 release under neutral conditions to promote wound healing in diabetic mice and rabbit. Herein, a defect-engineered cobalt phosphide (CoP) catalyst was designed by introducing a neutral single-metal electrocatalytic Hydrogen valence state channel into CoP. By effectively regulating the formation and transfer of *H active species during the CoP catalytic process, a considerable enhancement in neutral electrocatalytic H 2 evolution performance was achieved (−78.0 mV@-10.0 mA cm −2 ). Based on this superior catalytic performance, we developed a flexible electrode (namely, CoP/flexible gold electrode made by screen printing (FGSP) by combining a convenient electrolysis platform with continuous electrolyte supply and FGSP, enabling customized H 2 release and accelerating wound healing in diabetic mice and rabbits. Notably, the designed flexible electrode features adjustable dimensions, interchangeable substrates, and material adaptability, meeting the diverse needs of clinical and basic research and demonstrating significant potential for applications in clinical medicine.}, archive = {J_ANGEW}, author = {Xianzhu Luo and Xiangcheng Zhang and Xue Wen and Rui Wang and Qingguo Zhang and Pan Luo and Fabiao Yu and Hongshuai Cao}, doi = {10.1002/anie.202422091}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422091}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Valence state hydrogen channel enhances sustained and controllable electrocatalytic hydrogen evolution in diabetic skin wound healing}, volume = {64}, year = {2025}, }
• (2025). Platinum-nickel oxide cluster-cluster heterostructure enabling fast hydrogen evolution for anion exchange membrane water electrolyzers. ANGEW, 64(15), e202422062. (www)

  @article{ , abstract = {Carbon black has been extensively employed as the support for noble metal catalysts for electrocatalysis applications. However, the nearly catalytic inertness and weak interaction with metal species of carbon black are two major obstacles that hinder the further improvement of the catalytic performance. Herein, we report a surface functionalization strategy by decorating transition metal oxide clusters on the commercial carbon black to offer specific catalytic activity and enhanced interaction with metal species. In the case of NiO x cluster-decorated carbon black, a strongly coupled cluster-cluster heterostructure consisting of Pt clusters and NiO x clusters (Pt−NiO x /C) is formed and delivers greatly enhanced alkaline hydrogen evolution kinetics. The NiO x clusters can not only accelerate the hydrogen evolution process as the co-catalyst, but also optimize the adsorption of H intermediates on Pt and stabilize the Pt clusters. Notably, the anion exchange membrane water electrolyzer with Pt−NiO x /C as the cathode catalyst (with a loading of only 50 μ g Pt cm −2 ) delivers the most competitive electrochemical performance reported to date, requiring only 1.90 V to reach a current density of 2 A cm −2 . The results demonstrate the significance of surface functionalization of carbonaceous supports toward the development of advanced electrocatalysts.}, archive = {J_ANGEW}, author = {Xinying Zheng and Xiaozhong Zheng and Mingxia Gao and Yongfeng Liu and Hongge Pan and Wenping Sun}, doi = {10.1002/anie.202422062}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Platinum-nickel oxide cluster-cluster heterostructure enabling fast hydrogen evolution for anion exchange membrane water electrolyzers}, volume = {64}, year = {2025}, }
• (2025). Soluble covalent organic frameworks as efficient lithiophilic modulator for high-performance lithium metal batteries. ANGEW, 64(15), e202422040. (www)

  @article{ , abstract = {Lithium metal batteries (LMBs) are regarded as the potential alternative of lithium-ion batteries due to their ultrahigh theoretical specific capacity (3860 mAh g −1 ). However, severe instability and safety problems caused by the dendrite growth and inevitable side reactions have hindered the commercialization of LMBs. To solve them, in this contribution, a design strategy of soluble lithiophilic covalent organic frameworks (COFs) is proposed. By introducing polyethylene glycol as the side chains, two COFs ( CityU-28 and CityU-29 ) not only become soluble for the facile coating technique, but also can facilitate the lithium-ion migration in batteries. Furthermore, when coated on the lithium anode of LMB, both COFs can act as artificial solid electrolyte interphase to prevent dendrite growth thus enabling the long-term stability of the cells. Notably, the symmetric CityU-29@Li cell can work for more than 5000 h at a current density of 2 mA cm −2 and an areal capacity of 1 mAh cm −2 . A remarkable capacity retention of 78.9 % after 1500 cycles and a Coulombic efficiency of about 99.9 % at 1.0 C can also be realized in CityU-29@Li||LiFePO 4 full cell. This work could provide a universal design strategy for soluble COFs and enlighten their application in diverse scenarios, especially energy-related fields.}, archive = {J_ANGEW}, author = {Shen Xu and Tuoya Naren and Yanwei Zhao and Qianfeng Gu and Ting Wai Lau and Chun-Sing Lee and Fu-Rong Chen and Jun Yin and Libao Chen and Qichun Zhang}, doi = {10.1002/anie.202422040}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202422040}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Soluble covalent organic frameworks as efficient lithiophilic modulator for high-performance lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Renewable terephthalates and aromatic diisocyanates from galactose. ANGEW, 64(15), e202421540. (www)

  @article{ , abstract = {Aromatic diisocyanates, invaluable commodity chemicals for polymer manufacturing, are produced annually on megaton scales from petroleum-derived diamines via phosgenation. Existing routes toward renewable alternatives are sparse and limited by access to functionalized aromatic starting materials, such as terephthalates. Herein, we report the development of a robust route to renewable terephthalates and aromatic diisocyanates from D-galactose via Eastwood olefination and Diels–Alder cycloaddition, followed by a mild electrochemical decarboxylative aromatization. This process was developed and applied on gram-scale to synthesize terephthalates, which were transformed into aromatic diisocyanates via Curtius rearrangement in flow. We demonstrate gram-scale preparation of 1,4-phenylene diisocyanate and 2,5-toluene diisocyanate and formulation of these monomers to prepare fully renewable thermoplastic polyurethanes. Preparation of these renewable aromatic diisocyanates proceeds without the use of high-pressure gases or costly transition-metals and represents a novel route to fully renewable aromatic diisocyanates.}, archive = {J_ANGEW}, author = {Matthew W. Halloran and Roxanne Naumann and Aanchal Jaisingh and Nathan A. Romero and Michael D. Burkart}, doi = {10.1002/anie.202421540}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202421540}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Renewable terephthalates and aromatic diisocyanates from galactose}, volume = {64}, year = {2025}, }
• (2025). Catalysis-driven active transport across a liquid membrane. ANGEW, 64(15), e202421234. (www)

  @article{ , abstract = {Biology has mastered energy transduction, converting energy between various forms, and employing it to drive its vital processes. Central to this is the ability to use chemical energy for the active transport of substances, pumping ions and molecules across hydrophobic lipid membranes between aqueous (sub)cellular compartments. Biology employs information ratchet mechanisms, where kinetic asymmetry in the fuel-to-waste (i. e., substrate-to-product) conversion results in catalysis-driven active transport. Here, we report an artificial system for catalysis-driven active transport across a hydrophobic phase, pumping a maleic acid cargo between aqueous compartments. We employ two strategies to differentiate the conditions in either compartment, showing that active transport can be driven either by adding fuel to a single compartment, or by differentiating the rates of activation and/or hydrolysis when fuel is present in both compartments. We characterize the nonequilibrium system through complete kinetic analysis. Finally, we quantify the energy transduction achieved by the catalysis-driven active transport and establish the emergence of positive and negative feedback mechanisms within the system.}, archive = {J_ANGEW}, author = {Kaiyuan Liang and Federico Nicoli and Shaymaa Al Shehimy and Emanuele Penocchio and Simone Di Noja and Yuhan Li and Claudia Bonfio and Stefan Borsley and Giulio Ragazzon}, doi = {10.1002/anie.202421234}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202421234}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalysis-driven active transport across a liquid membrane}, volume = {64}, year = {2025}, }
• (2025). An amorphous donor-acceptor conjugated polymer with both high charge carrier mobility and luminescence quantum efficiency. ANGEW, 64(15), e202421199. (www)

  @article{ , abstract = {Organic semiconducting polymers play a pivotal role in the development of field-effect transistors (OFETs) and organic light-emitting diodes (OLEDs), owing to their cost-effectiveness, structural versatility, and solution processability. However, achieving polymers with both high charge carrier mobility (μ) and photoluminescence (PL) quantum yield (Φ) remains a challenge. In this work, we present the design and synthesis of a novel donor-acceptor π-conjugated polymer, TTIF-BT , featuring a di-Thioeno[3,2-b] ThioenoIndeno[1,2-b] Fluorene ( TTIF ) backbone as the donor component. TTIF-BT exhibits comparable hole mobility and enhanced interchain-mediated emissions compared to state-of-the-art semiconducting IDT-BT , leading to a remarkable Φ ⋅ μ value of ~0.084 cm 2 V −1 s −1 . Through time-resolved absorption and PL techniques, we propose a model to extract the spectral weight of interchain-mediated emissions, yielding 62 % in TTIF-BT . Our results introduce a high-performance semiconducting polymer, which has potential use in next-generation organic optoelectronic devices, including electrically-driven polymer lasers and active-matrix display technologies.}, archive = {J_ANGEW}, author = {Mingcong Wang and Guangjie Xia and Chen Yang and Lu Zhang and Mark Nikolka and Weimin Zhang and Camila Cendra and Wanli Liu and Shunan Zhao and Jinfeng Zeng and Cao Zou and Julien Gorenflot and Alberto Salleo and Frédéric Laquai and Henning Sirringhaus and Iain McCulloch and Hu Chen}, doi = {10.1002/anie.202421199}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202421199}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An amorphous donor-acceptor conjugated polymer with both high charge carrier mobility and luminescence quantum efficiency}, volume = {64}, year = {2025}, }
• (2025). Tandem catalysis for plastic depolymerization: In situ hydrogen generation via methanol aqueous phase reforming for sustainable polyethylene hydrogenolysis. ANGEW, 64(15), e202420748. (www)

  @article{ , abstract = {Depolymerizing plastic waste through hydrogen-based processes, such as hydrogenolysis and hydrocracking, presents a promising solution for converting plastics into liquid fuels. However, conventional hydrogen production methods rely heavily on fossil fuels, exacerbating global warming. This study introduces a novel approach to plastic waste hydrogenolysis that utilizes in situ hydrogen generated via the aqueous phase reforming (APR) of methanol, a biomass-derived chemical offering a more sustainable alternative. Our results show that a bimetallic Ru−Pt/TiO 2 catalyst achieved high conversion (85.1 %) and selectivity (81.0 %) towards liquid fuels and lubricant oils in a tandem process combining polyethylene (PE) hydrogenolysis and methanol APR. By tuning the metal loading, we identified that Pt enhances hydrogen production through methanol APR, while Ru drives C−C bond cleavage, which is crucial for PE hydrogenolysis. Isotope labeling analysis confirmed that hydrogen generated from methanol APR is effectively utilized in the PE hydrogenolysis reaction. This method was also successfully applied to post-consumer polyolefin waste, with selectivity toward valuable products ranging from 75.0 % to 88.9 %. This study highlights an innovative strategy to reduce reliance on fossil-fuel-derived hydrogen in plastic waste depolymerization, promoting both sustainability and environmental protection.}, archive = {J_ANGEW}, author = {Junsung Lee and Taeeun Kwon and Ki Hyuk Kang and Wangyun Won and Insoo Ro}, doi = {10.1002/anie.202420748}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202420748}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem catalysis for plastic depolymerization: In situ hydrogen generation via methanol aqueous phase reforming for sustainable polyethylene hydrogenolysis}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of α-hydroxy allyl ketones via BINAP-CuH-catalyzed hydroacylation. ANGEW, 64(15), e202420106. (www)

  @article{ , abstract = {Catalytic hydrocupration of unsaturated carbon-carbon bonds to generate organometallic nucleophiles has recently become an attractive alternative to conventional stoichiometric reagents in the stereoselective synthesis. Herein, we have developed an efficient and economical method to synthesize enantiopure α -hydroxy allyl ketones via a copper hydride (CuH)-catalyzed hydroacylation of alkoxyallenes, a significant advancement given the scarcity of reports on such scaffolds in the literature. DFT calculations reveal that this reaction proceeds through the nucleophilic attack of a kinetically favourable Z -selective allyl-copper intermediate on acid anhydrides via a six-membered chair-like transition state, stabilized by strongly attractive non-covalent interactions that ultimately leads to high level of enantioselectivities using the simple BINAP ligand. This method successfully overcomes the challenges of over-reduction of carbonyl functionality in the presence of CuH-complex, olefin isomerization and the presence of a highly enolizable α -stereocenter, which can lead to erosion in enantioselectivities, making our strategy highly desirable. The reaction exhibits a wide range of substrate scope including symmetrical as well as carbonic anhydrides with both aromatic, and aliphatic substitutions. In addition, α -substituted acid anhydrides provide exclusive syn -selective α,α′ -disubstituted allyl ketones in excellent enantiomeric ratios, where the nucleophilic allylation occurs on one of the carbonyls containing the matched α- stereocenter, confirmed with mechanistic studies.}, archive = {J_ANGEW}, author = {Sundaram Maurya and N. Navaneetha and Prativa Behera and Jagadeesh Babu Nanubolu and Lisa Roy and Rambabu Chegondi}, doi = {10.1002/anie.202420106}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202420106}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of α-hydroxy allyl ketones via BINAP-CuH-catalyzed hydroacylation}, volume = {64}, year = {2025}, }
• (2025). Interfacial asymmetrically coordinated Zn−MOF for high-efficiency electrosynthetic oxime. ANGEW, 64(15), e202419550. (www)

  @article{ , abstract = {Oximes are important intermediates for various chemicals synthesis such as pharmaceuticals, among which one vital precursor for producing neurological disease, antimicrobial and anticancer agents is piperidone oxime (PDO). Compared with conventional thermocatalytic method, it's more attractive to synthesize PDO via green electrocatalytic technology especially utilizing waste nitrogen oxides gas as nitrogen source. However, there are great challenges in catalyst design for high-efficiency electrosynthetic oxime due to the low electron transport rate and multiple competing reactions. Herein, we propose an interfacial coordination strategy based on metal–organic frameworks (MOF) electrocatalyst for the first time to promote oxime electrosynthesis, by building Zn−O bridges between graphite felt (GF) and zeolitic imidazolate framework (ZIF-7/CGF). Specially, ZIF-7/CGF delivers a Faraday efficiency (FE) of 75.9 % with yield up to 73.1 % for 1-methyl-4-piperidone oxime, which is far superior to the catalyst without Zn−O bridges (a FE of 10.7 % and yield of 10.3 %). In-depth mechanism study shows that the introducing Zn−O bridges can promote the electron transfer and induce Zn sites transforming into distorted tetrahedron (Zn-N 3 O) coordination mode, which benefits for intermediates adsorption and conversion. The developed strategy presents wide universalities towards various oximes electrosynthesis and adapts to other MOF materials (ZIF-8, ZIF-4). This work provides new insights for electrosynthetic organic chemicals and upgrading nitrogen cycle through rational design surficial coordinated electrocatalysts.}, archive = {J_ANGEW}, author = {Jiawei Kang and Peisen Liao and Runan Xiang and Wenpei Liao and Chenyu Yang and Shihan Wang and Qinghua Liu and Guangqin Li}, doi = {10.1002/anie.202419550}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {15}, pages = {e202419550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial asymmetrically coordinated Zn−MOF for high-efficiency electrosynthetic oxime}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Zinc coordination-polymer-mediated self-assembly of nanoparticles into “Brick-and-mortar” membranes for hydrogen separation. ANGEW, 64(14), e202581462. (www)

  @article{ , archive = {J_ANGEW}, author = {Xinxin Li and Chengli Jiao and Xiaoqian Zhang and Xiaoya Xu and Saeed Gul and Fangyi Liang and Jürgen Caro and Heqing Jiang}, doi = {10.1002/anie.202581462}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202581462}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Zinc coordination-polymer-mediated self-assembly of nanoparticles into “Brick-and-mortar” membranes for hydrogen separation}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Fluorescent artificial receptor for dopamine based on molecular recognition-driven dynamic covalent chemistry in a lipid nanoreactor. ANGEW, 64(14), e202581461. (www)

  @article{ , archive = {J_ANGEW}, author = {Bohdan Kozibroda and Jean-Marie Lehn and Andrey S. Klymchenko}, doi = {10.1002/anie.202581461}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202581461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Fluorescent artificial receptor for dopamine based on molecular recognition-driven dynamic covalent chemistry in a lipid nanoreactor}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: In-tandem electrochemical reduction of nitrate to ammonia on ultrathin-sheet-assembled Iron–Nickel alloy nanoflowers. ANGEW, 64(14), e202505571. (www)

  @article{ , archive = {J_ANGEW}, author = {Kartick Chandra Majhi and Hongjiang Chen and Asma Batool and Qi Zhu and Yangxin Jin and Shengqin Liu and Patrick H.-L. Sit and Jason Chun-Ho Lam}, doi = {10.1002/anie.202505571}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202505571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: In-tandem electrochemical reduction of nitrate to ammonia on ultrathin-sheet-assembled Iron–Nickel alloy nanoflowers}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: From autonomous chemical micro-/Nanomotors to rationally engineered bio-interfaces. ANGEW, 64(14), e202505569. (www)

  @article{ , archive = {J_ANGEW}, author = {Miaomiao Ding and Bin Chen and Daniela A. Wilson and Yingfeng Tu and Fei Peng}, doi = {10.1002/anie.202505569}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202505569}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: From autonomous chemical micro-/Nanomotors to rationally engineered bio-interfaces}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: Molecular design for dual circularity: Polyester with complementary mechanical and chemical recyclability under mild conditions. ANGEW, 64(14), e202505568. (www)

  @article{ , archive = {J_ANGEW}, author = {Yue Han and Pingxia Zhang and Heng Zhou and Tong Zhao and Karin Odelius and Minna Hakkarainen}, doi = {10.1002/anie.202505568}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202505568}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: Molecular design for dual circularity: Polyester with complementary mechanical and chemical recyclability under mild conditions}, volume = {64}, year = {2025}, }
• (2025). Outside front cover: A metastable state facilitates low temperature CO oxidation over pt nanoparticles. ANGEW, 64(14), e202505562. (www)

  @article{ , archive = {J_ANGEW}, author = {Samantha L. Le and Christopher R. O'Connor and Taek-Seung Kim and Christian Reece}, doi = {10.1002/anie.202505562}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202505562}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside front cover: A metastable state facilitates low temperature CO oxidation over pt nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Hyeon jeong lee. ANGEW, 64(14), e202503727. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202503727}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202503727}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hyeon jeong lee}, volume = {64}, year = {2025}, }
• (2025). Selective and efficient upcycling of polyesters from waste plastic blends enabled by a rationally designed manganese pincer catalyst. ANGEW, 64(14), e202502923. (www)

  @article{ , abstract = {Herein, we report a new class of earth-abundant pincer manganese catalysts that not only enable the efficient conversion of single-component post-consumer polyesters with a turnover number (TON) of up to 5300, but more importantly, allow the selective upcycling of polyesters from waste plastic blends (e.g., nylon, PA; polyethylene, PE; polyurethane, PU; polyvinyl chloride, PVC; cotton) or contaminants such as pigment, aluminum, or glass into highly valuable oxygenated products under mild conditions. Detailed mechanistic studies combined with DFT calculations revealed that the exceptional efficiency of this protocol is due to the use of rationally designed quinaldine-based PNN H -type Mn complexes with an extended π-system and an N−H moiety on the side arm to simultaneously enhance the stability and reactivity of the catalyst. In addition, the incorporation of dual metal-ligand cooperation (MLC) relay catalysis more effectively facilitates the key steps of this transformation, including H 2 activation and hydrogen bond-assisted hydride transfer.}, archive = {J_ANGEW}, author = {Yue Hu and Yanwei Gu and Yongjing Dong and Yiqing Wang and Juanfang Xu and Yingying Han and Chijian Zhang and Yinjun Xie}, doi = {10.1002/anie.202502923}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202502923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective and efficient upcycling of polyesters from waste plastic blends enabled by a rationally designed manganese pincer catalyst}, volume = {64}, year = {2025}, }
• (2025). Disturbance-triggered instant crystallization activating bioinspired emissive gels. ANGEW, 64(14), e202501054. (www)

  @article{ , abstract = {Many marine organisms feature sensitive sensory-perceptual systems to sense the surrounding environment and respond to disturbance with intense bioluminescence. However, it remains a great challenge to develop artificial materials that can sense external disturbance and simultaneously activate intense luminescence, although such materials are attractive for visual sensing and intelligent displays. Herein, we present a new class of bioinspired smart gels constructed by integrating hydrophilic polymeric networks, metastable supersaturated salt and fluorophores containing heterogenic atoms. Upon external disturbance, the composite gels undergo an instant and reversible soft-rigid state transition, simultaneously turning on intense fluorescence and activating ultralong afterglow emission with a maximum lifetime of 877.15 ms. The experimental results and molecular dynamics simulations reveal that the disturbance-induced luminescence mainly results from the geometrical confinement of aggregated fluorophores and enhanced molecular interactions to immensely suppress the non-radiative dissipation. Given their versatile and sensitive disturbance-responsiveness, dynamic interactive painting and 3D smart optical displays are demonstrated. This study paves a new avenue to achieve disturbance-sensing soft materials and promotes the development of smart visual sensors and interactive optical displays.}, archive = {J_ANGEW}, author = {Min Qi and Jianxiang Huang and Junjie Wei and Jiayin Zhou and Depeng Liu and Longqiang Li and Wuzhen Luo and Guangqiang Yin and Tao Chen}, doi = {10.1002/anie.202501054}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202501054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Disturbance-triggered instant crystallization activating bioinspired emissive gels}, volume = {64}, year = {2025}, }
• (2025). Monomer design enables mechanistic mapping of anionic ring-opening polymerization of aromatic thionolactones. ANGEW, 64(14), e202500581. (www)

  @article{ , abstract = {Degradable chalcogenide polyesters, e.g., polythioesters (PTEs), typically exhibit improved thermal, mechanical, and optical properties. Anionic ring-opening polymerization (ROP) of thionolactones, an intrinsically promising yet underexplored approach to accessing PTEs, however, is still limited by: intolerance of metal catalysts, inadequate control over chain growth, and the absence of aromatic system. Monomer design-boosted mechanistic studies may address the above challenges. Here, we present a new and highly reactive thionolactone synthesized from 1,1′-binaphthyl-2,2′-diol (BINOL). Our investigations into polymerization kinetics and thermodynamics have underscored the importance of rapid initiation, eventually leading to the discovery of tetrabutylammonium 2-naphthyl-thiocarboxylate as a distinctive initiator that enables genuinely controlled and living polymerization of thionolactones. Ultimately, the atropisomerism inherent in BINOL has resulted in the creation of axially chiral PTE materials with tailored molecular weights, enantiomeric compositions, and topologies.}, archive = {J_ANGEW}, author = {Shaoqiu Zheng and Shu-Sen Chen and Yang-Yang Li and Minjian Liao and Xuhui Liang and Ke Li and Xiaopeng Li and Jinming Hu and Dian-Feng Chen}, doi = {10.1002/anie.202500581}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202500581}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Monomer design enables mechanistic mapping of anionic ring-opening polymerization of aromatic thionolactones}, volume = {64}, year = {2025}, }
• (2025). Tunable catalytic vertex wall chemistry in metal-free covalent organic frameworks for enhanced oxygen reduction. ANGEW, 64(14), e202500336. (www)

  @article{ , abstract = {Metal-free covalent organic frameworks (COFs) have emerged as promising catalysts for the oxygen reduction reaction (ORR) because of their unique structural properties and notable stability. To enhance both catalytic activity and selectivity, a variety of linkers and linkages have been investigated in efforts to precisely engineer COFs. However, the impact of vertex structures within COFs on ORR catalysis remains largely underexplored. Here, to modulate COF catalytic performance, we introduce tunable catalytic vertex wall chemistry by introducing diverse triazine and thiophene units. The catalytic vertex wall approach allows the fine-tuning of electronic surface states, leading to improved intermediate adsorption characteristics and accelerated ORR activity. Remarkably, the engineered COF achieved a half-wave potential of 0.76 V, surpassing COFs modified by linker or linkage strategies. Theoretical calculations suggest that this enhanced activity arises from the strong binding affinity of OOH* intermediates to carbon atoms adjacent to the thiophene vertex, facilitating OOH* reduction to a O 2 molecule, which is the rate-limiting step of the ORR. These findings reveal the pivotal role of vertex wall engineering in conjugated COF frameworks, and offer critical insights to advance COFs design toward superior ORR performance.}, archive = {J_ANGEW}, author = {Changqing Li and Zhaoying Wang and Yucheng Jin and Zhongping Li and Jong-Pil Jeon and Songlin Zhao and Yanhua Shao and Feng Tang and Won-Yeong Kim and Runnan Guan and Jeong-Min Seo and Zonghoon Lee and Sang-Young Lee and Jong-Beom Baek}, doi = {10.1002/anie.202500336}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202500336}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tunable catalytic vertex wall chemistry in metal-free covalent organic frameworks for enhanced oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). Pi-stacking geometry directed supramolecular secondary building units shaping hydrogen-bonded frameworks for intensive NH3 adsorption. ANGEW, 64(14), e202500268. (www)

  @article{ , abstract = {Exploiting supramolecular secondary building units (SSBUs) for developing porous crystalline materials represents an exciting breakthrough that extends the boundaries of reticular chemistry. However, shaping polynuclear clusters sustained by non-covalent interactions for the assembly of hydrogen-bonded frameworks remains a critical challenge. This study presents a novel strategy to stabilize SSBUs by tuning the π-stacking geometry of conjugated building blocks, facilitating the creation of hydrogen-bonded frameworks with tailored architectures for demanding gas separation. Specifically, parallel-displaced π–π stackings of aromatic heterocycles bearing carboxyls promote the formation of SSBUs bridged by ammonium cations [NH 4 + ] 8 [COO − ] 8 ( SSBU-4 ), enabling the assembly of hydrogen-bonded frameworks with permanent porosity and structural diversity influenced by the solvent effect. Comparatively, the non-heterocyclic building units exhibit geometrically- or energetically-unfavorable π stackings, resulting in fragile frameworks that collapse after removing disordered guests. Significantly, the heterocycle conjugated frameworks contain abundant open Brønsted acid N−H sites within pore channels, demonstrating remarkable NH 3 adsorption ability among diverse industrial gases with a high capacity (275.7 mL/g, at 273 K, 100 kPa) as compared to reported porous molecular crystals.}, archive = {J_ANGEW}, author = {Xiaojun Ding and Qiang Gao and Yi Su and Jing Chen and Gang Ye}, doi = {10.1002/anie.202500268}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202500268}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pi-stacking geometry directed supramolecular secondary building units shaping hydrogen-bonded frameworks for intensive NH3 adsorption}, volume = {64}, year = {2025}, }
• (2025). Transient allosteric regulation of catalysis by effector switching in a Pt2L4 cage. ANGEW, 64(14), e202500214. (www)

  @article{ , abstract = {The complexity of allosteric enzymatic regulation continues to inspire synthetic chemists seeking to emulate interconnected biological systems. In this work, a Pt 2 L 4 cage capable of catalyzing the cyclization reaction of an alkynoic tosyl amide is orthogonally coupled to a diacid-catalyzed carbodiimide-hydration cycle. This new Pt-catalyzed cyclization reaction is demonstrated to exhibit electronic regulation by inclusion of different guest effectors. The orthogonal diacid-catalyzed carbodiimide hydration cycle produces transiently diverse guests that influence the rate of the Pt-catalyzed cyclization reaction to different extents. Further complexity can be introduced to the system through displacing the transiently-formed, weakly bound anhydride guest with the stronger binding fumaronitrile, affecting the catalytic rate to a larger extent for the duration of the orthogonal reaction cycle. The modulation of a Pt-catalyzed cyclization reaction can thus be regulated transiently over the course of the reaction— either up- or down-regulating the turnover frequency (TOF)—via coupling with a temporally controllable orthogonal process. This study demonstrates that principles of allosteric enzymatic regulation can also be applied to simple artificial systems.}, archive = {J_ANGEW}, author = {Zoe Ashbridge and Joost N. H. Reek}, doi = {10.1002/anie.202500214}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202500214}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transient allosteric regulation of catalysis by effector switching in a Pt2L4 cage}, volume = {64}, year = {2025}, }
• (2025). Liquid crystal-engineered polydimethylsiloxane: Enhancing intrinsic thermal conductivity through high grafting density of mesogens. ANGEW, 64(14), e202500173. (www)

  @article{ , abstract = {The increasing power and integration of electronic devices have intensified serious heat accumulation, driving the demand for higher intrinsic thermal conductivity in thermal interface materials, such as polydimethylsiloxane (PDMS). Grafting mesogens onto PDMS can enhance its intrinsic thermal conductivity. However, the high stability of the PDMS chain limits the grafting density of mesogens, restricting the improvement in thermal conductivity. This work proposes a new strategy to efficiently introduce mesogens onto PDMS through ring-opening copolymerization of liquid crystal cyclosiloxane and octamethylcyclotetrasiloxane, enhancing the grafting density. The relationship between the grafting density and intrinsic thermal conductivity of liquid crystal polydimethylsiloxane (LC-PDMS) is investigated by nonequilibrium molecular dynamics (NEMD) simulations. Based on the simulation results, LC-PDMS with enhanced intrinsic thermal conductivity is synthesized. When the grafting density of mesogens reaches 77.4 %, its intrinsic thermal conductivity coefficient ( λ ) increases to 0.56 W/(m⋅K), showing a 180.0 % improvement over ordinary PDMS (0.20 W/(m⋅K)). The LC-PDMS also exhibits the low dielectric constant ( ϵ , 2.69), low dielectric loss tangent (tan δ , 0.0027), high insulation performance (volume resistivity, 3.51×10 13 Ω⋅cm), excellent thermal stability (heat resistance index, 217.8 °C) and excellent hydrophobicity (water contact angle, 137.4°), fulfilling the comprehensive requirements of advanced thermal interface materials.}, archive = {J_ANGEW}, author = {Haitian Zhang and Yongqiang Guo and Yizhi Zhao and Qiuyu Zhu and Mukun He and Hua Guo and Xuetao Shi and Kunpeng Ruan and Jie Kong and Junwei Gu}, doi = {10.1002/anie.202500173}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202500173}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Liquid crystal-engineered polydimethylsiloxane: Enhancing intrinsic thermal conductivity through high grafting density of mesogens}, volume = {64}, year = {2025}, }
• (2025). In-tandem electrochemical reduction of nitrate to ammonia on ultrathin-sheet-assembled iron-nickel alloy nanoflowers. ANGEW, 64(14), e202500167. (www)

  @article{ , abstract = {The development of alternative routes for ammonia (NH 3 ) synthesis with high Faradaic efficiency (FE) is crucial for energy conservation and to achieve zero carbon emissions. Electrocatalytic nitrate (NO 3 − ) reduction to NH 3 (e-NO 3 RRA) is a promising alternative to the energy-intensive, fossil-fuel-driven Haber–Bosch process. The implementation of this innovative NH 3 synthesis technique requires an efficient electrocatalyst and in-depth mechanistic understanding of e-NO 3 RRA. In this study, we developed an ultrathin sheet (μm) iron–nickel nanoflower alloy through electrodeposition and used it for e-NO 3 RRA under alkaline conditions. The prepared Fe−Ni alloy exhibited an FE of 97.28±1.36 % at −238 mV RHE and an NH 3 yield rate up to 3999.1±242.59 μg h −1 cm −2 . Experimental electrolysis, in situ Raman spectroscopy, and density functional theory calculations showed that the adsorption and reduction of NO 3 − to NO 2 − occurred on the Fe surface, whereas subsequent hydrogenation of NO 2 − to NH 3 occurred preferentially on the Ni surface. The catalysts exhibited comparable FE for at least 10 cycles, with a long-term stability of 216 h. Electron paramagnetic resonance results confirmed that adsorbed hydrogen was consumed during e-NO 3 RRA. This work introduces a sustainable, robust, and efficient Fe−Ni alloy electrocatalyst, offering an environmentally friendly approach for synthesizing NH 3 from NO 3 − -contaminated water.}, archive = {J_ANGEW}, author = {Kartick Chandra Majhi and Hongjiang Chen and Asma Batool and Qi Zhu and Yangxin Jin and Shengqin Liu and Patrick H.-L. Sit and Jason Chun-Ho Lam}, doi = {10.1002/anie.202500167}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202500167}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-tandem electrochemical reduction of nitrate to ammonia on ultrathin-sheet-assembled iron-nickel alloy nanoflowers}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic conversion of methane to ethane and propane using cobalt-cluster-activated GaN nanowires. ANGEW, 64(14), e202500158. (www)

  @article{ , abstract = {The photocatalytic nonoxidative coupling of methane (PNOCM) offers a promising route to synthesize valuable C 2+ hydrocarbons while minimizing side reactions. Oxide-based photocatalysts have been predominant in this field, but suffering from limited conversion rates, selectivity, and durability due to poor C−C coupling as well as overoxidation of CH 4 by lattice oxygen. Here, we introduce an advancement in PNOCM for methane conversion into ethane and propane using GaN, one of the most produced semiconductors, together with trace amounts of metallic cobalt clusters (0.1 wt %). The photocatalytic system exhibits outstanding stability, maintaining performance over 110 hours, achieving conversion rates of approximately 192.3 mmol g −1 h −1 for ethane and ~17.9 mmol g −1 h −1 for propane, with virtually no coke byproducts detected, representing the highest activity and stability ever reported to our knowledge. This high activity is attributed to the critical methane activation and C−C coupling on Co cluster, which can be greatly accelerated via the ultrafast photogenerated charge transfer from p-GaN to Co cluster. Additionally, the GaN support further synergistically enhances methane activation by in situ generating N−H and O−H species under reaction, as well as provides a vital anti-overoxidation effect to CH 4 for high selectivity and stability.}, archive = {J_ANGEW}, author = {Zhengwei Ye and Zhuoran Long and Bingxing Zhang and Ishtiaque Ahmed Navid and Jan Paul Menzel and Yifan Shen and Shubham Mondal and Facheng Guo and Theodore B. Norris and Victor S. Batista and Zetian Mi}, doi = {10.1002/anie.202500158}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202500158}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic conversion of methane to ethane and propane using cobalt-cluster-activated GaN nanowires}, volume = {64}, year = {2025}, }
• (2025). Fabrication strategies of mn2+-based scintillation screens for X-ray detection and imaging. ANGEW, 64(14), e202425661. (www)

  @article{ , abstract = {Scintillators play a pivotal role in multiple fields such as medical imaging, radioactive contaminant detection, non-destructive testing, high-energy physics and homeland security. However, the traditional inorganic scintillators are faced with the shortcomings of high fabrication cost and low light yield. In recent years, organic–inorganic hybrid metal halides have become the promising alternatives for their excellent luminescence properties, favorable air and irradiation stability, and low-cost preparation. Among them, organic–inorganic hybrid Mn(II) halides (OIMnHs) have attracted wide attention due to their particular flexible molecular structure design, easy synthesis and low toxicity. This minireview summarizes the latest progress in high performance Mn 2+ -Based scintillation screens. Herein, the scintillation mechanism of OIMnHs scintillators is firstly discussed. Then, the different synthesis methods of OIMnHs scintillators are briefly described, including solvent diffusion, cooling crystallization, evaporative crystallization and solid-state mechanochemical synthesis. After that, the recent strategies of OIMnHs for forming scintillation screens applying to X-ray imaging are emphatically reviewed, which are growing large single crystals, fabricating to glass or ceramic and blending with polymers. The fabrication progress and applications of OIMnHs-based scintillation screens were introduced and the structure–property relationship of these screens was discussed. Finally, the challenges of this new scintillator material are summarized, and the potential research directions for future exploration are proposed.}, archive = {J_ANGEW}, author = {Jiali Fan and Haibo Li and Wei Liu and Gangfeng Ouyang}, doi = {10.1002/anie.202425661}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fabrication strategies of mn2+-based scintillation screens for X-ray detection and imaging}, volume = {64}, year = {2025}, }
• (2025). Proximal oblique-packing of heptamethine cyanines through spiro-connection boosts triplet state generation in near-infrared. ANGEW, 64(14), e202425422. (www)

  @article{ , abstract = {Near-infrared (NIR) triplet dyes are the cornerstones of cutting-edge biomedical and material applications. The difficulty in rational development of triplet dyes increases exponentially as the absorption wavelength shifts deeper into the NIR range. Although classical H-/J-typed packing of NIR dyes has the potential to enhance intersystem crossing (ISC) compared with that in single-chromophore dyes, the triplet state quantum yields remain limited in such strategy. Herein, proximal oblique-packed (V-shaped) heptamethine cyanines ( SZ780 ) through spiro-connection were achieved. Multi-channel ultrafast ISC were direct observed in SZ780 and a record high ISC rate constant (up to ~10 11 s −1 ) is registered among all the reported NIR triplet dyes. SZ780 exhibits a triplet state quantum yield of 18.9 % upon excitation at 750 nm, which is almost an order of magnitude higher than that of the monomer ( IR780 , 2.1 %) and nearly threefold increase compared to that of the H-packed dimer ( SC780 ) (6.7 %). Moreover, SZ780 efficiently generates singlet oxygen under 808 nm light irradiation, inducing cancer cell apoptosis in vivo. These findings demonstrate that constructing V-aggregated dyes system by spiro-connection offers a powerful approach for the design of high-performance NIR triplet sensitizers.}, archive = {J_ANGEW}, author = {Xueli Wang and Jie Zhou and Mingkang Wang and Yuze Wang and Zhetao Shen and Haitao Sun and Zhubin Hu and Xiao Luo and Youjun Yang and Jinquan Chen}, doi = {10.1002/anie.202425422}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425422}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proximal oblique-packing of heptamethine cyanines through spiro-connection boosts triplet state generation in near-infrared}, volume = {64}, year = {2025}, }
• (2025). Metabolism-inspired chemical reaction networks for chemically driven dissipative oligoesterification. ANGEW, 64(14), e202425407. (www)

  @article{ , abstract = {Metabolism is a complex network of chemical reactions in which transient biomolecules are continuously produced and degraded. Mimicking this dynamic process in synthetic systems poses a considerable challenge, as it requires designs that enable the exchange of energy and matter among transient molecules. In this study, we explored a chemically driven oligoesterification process operating within a highly intricate reaction network and constructed a dynamic library of transient oligoesters. Our kinetic analysis uncovered an intriguing phenomenon: oligoesters undergo parasitic exchanges, consuming one another to sustain the system's dynamics before reaching thermodynamic equilibrium. This discovery opens new opportunities for designing synthetic systems that replicate the complexity and self-sustaining behavior of metabolic processes.}, archive = {J_ANGEW}, author = {Yeonsoo Lim and Gyunam Park and Hojin An and Jonghwa Han and Joonhyun Bae and Ji-Hyun Kim and Yan Lee and Kyungtae Kang and Jaeyoung Sung and Sunbum Kwon}, doi = {10.1002/anie.202425407}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425407}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metabolism-inspired chemical reaction networks for chemically driven dissipative oligoesterification}, volume = {64}, year = {2025}, }
• (2025). Dual-asymmetric solid additive enables eco-friendly all-polymer solar cells with over 19 % efficiency and excellent stability. ANGEW, 64(14), e202425267. (www)

  @article{ , abstract = {The optimization of morphology in all-polymer solar cells (all-PSCs) often relies on the use of solvent additives. However, their tendency to remain trapped in the device due to high boiling points leads to performance degradation over time. In this study, we introduce a novel approach involving the design and synthesis of one dual-asymmetric solid additive featuring mono-brominated-asymmetric dithienothiophene (SL-1). Leveraging the synergistic effects of asymmetric substitution and core structures, fine-tuning the molecule dipole moment enhancing solid additive interactions with host materials, thereby regulating polymer aggregation and influencing blend morphology during device fabrication. This results in highly ordered π–π stacking and a favorable phase-separated morphology within all-polymer active layer. Our work achieved a record efficiency of 19.19 % in eco-friendly all-PSCs, significantly outperforming SL-0 (18.37 %) and SL-2 (16.60 %), both featuring an asymmetric core. Furthermore, SL-1-treated all-PSCs retain over 90 % of their initial efficiency after 2140 hours of operation, with an extrapolated T 80 lifetime reaching 12400 hours. This represents a significant improvement in stability compared to devices treated with solvent additive (1-CN), which typically exhibits a T 90 lifetime of 700 hours. Our findings underscore the efficacy of utilizing dual-asymmetric solid additives as a straightforward and viable strategy for optimizing all-polymer morphology. SL-1 represents a promising advancement towards eco-friendly fabrication and application of high-efficiency and stable all-PSCs.}, archive = {J_ANGEW}, author = {Qiming Liang and Henan Li and Wan Xu and Junyi Lu and Ruijie Ma and Qingqing Bai and Xiaokang Sun and Mingqing Chen and Liangxiang Zhu and Qian Liu and Yuting Guo and Guangye Zhang and Qifan Xue and Agnieszka Iwan and Pei Cheng and Hanlin Hu and Hua Wang and Junwu Chen and Li Niu and Huiliang Sun}, doi = {10.1002/anie.202425267}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425267}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-asymmetric solid additive enables eco-friendly all-polymer solar cells with over 19 % efficiency and excellent stability}, volume = {64}, year = {2025}, }
• (2025). Ultrafast synthesis of nanoscale metal borides for efficient hydrogen evolution. ANGEW, 64(14), e202425257. (www)

  @article{ , abstract = {Nanoscale metal borides, with exceptional physicochemical properties, have been attracted widespread attention. However, traditional synthesis methods of metal borides often lead to surface coking and large particle sizes. Herein, we have employed a flash Joule heating (FJH) technique to enable the ultrafast synthesis of metal boride nanomaterials. The synthesized materials encompass a wide range of diverse categories, including alkaline-earth metal borides (CaB 6 ), transition metal borides (TiB 2 , VB 2 , CrB 2 , MoB, MoB 2 , MnB 2 , MnB 4 , FeB, CoB, NiB), noble-metal borides (RuB 2 , RuB 1.1 ), and rare-earth metal borides (LaB 6 , CeB 6 ). As an example, the RuB 2 demonstrates highly desirable electrocatalytic performance for all-pH hydrogen evolution reaction (HER). Especially, under the acidic condition, it exhibits an overpotential as low as 15 mV at a current density of 10 mA cm −2 , with a nearly 100 % faradic efficiency. Additionally, in situ Raman spectra confirm that both Ru and B sites serve as active sites for the HER. Moreover, the stability of RuB 2 can be further enhanced by optimizing the microenvironments of the anolyte composition (H + , K + ). More importantly, the experimental and density functional theory (DFT) calculations reveal that the co-existence of H + and K + localized around the RuB 2 plays a crucial role in further enhancing the stability.}, archive = {J_ANGEW}, author = {Tingting Liu and Chen Chen and Zonghua Pu and Qiufeng Huang and Jiadong Jiang and Min Han and Wei Chen and Guangtao Yu and Yuzhi Sun and Shengyun Huang and Qingjun Chen and Abdullah M. Al-Enizi and Ayman Nafady and Xueqin Mu and Shichun Mu}, doi = {10.1002/anie.202425257}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425257}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrafast synthesis of nanoscale metal borides for efficient hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). A two-in-one strategy to simultaneously boost the site density and turnover frequency of Fe−N−C oxygen reduction catalysts. ANGEW, 64(14), e202425196. (www)

  @article{ , abstract = {Site density (SD) and turnover frequency (TOF) are the two fundamental kinetic descriptors that determine the oxygen reduction activity of iron-nitrogen-carbon (Fe−N−C) catalysts that represent the most promising alternatives to precious and scarce platinum. However, it remains a grand challenge to simultaneously optimize these two parameters in a single Fe−N−C catalyst. Here we show that treating a typical Fe−N−C catalyst with ammonium iodine (NH 4 I) vapor via a one-step chemical vapor deposition process not only increases the surface area and porosity of the catalyst (and thus enhanced exposure of active sites) via the etching effect of the in situ released NH 3 , but also regulates the electronic structure of the Fe−N−C moieties by the iodine dopants incorporated into the carbon matrix. As a result, the NH 4 I-treated Fe−N−C catalyst possesses both high values in the SD of 2.15×10 19 sites g −1 (×2 enhancement compared to the untreated counterpart) and TOF of 3.71 electrons site −1 s −1 (×3 enhancement) that correspond to a high mass activity of 12.78 A g −1 , as determined by in situ nitrite stripping technique. Moreover, this catalyst exhibits an excellent oxygen reduction activity in base with a half-wave potential ( E 1/2 ) of 0.924 V and acceptable activity in acid with E 1/2 =0.795 V, and superior power density of 249.1 mW cm −2 in a zinc-air battery.}, archive = {J_ANGEW}, author = {Jianbin Liu and Yao Liu and Bing Nan and Dashuai Wang and Christopher Allen and Zhichao Gong and Guanchao He and Kaixing Fu and Gonglan Ye and Huilong Fei}, doi = {10.1002/anie.202425196}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425196}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A two-in-one strategy to simultaneously boost the site density and turnover frequency of Fe−N−C oxygen reduction catalysts}, volume = {64}, year = {2025}, }
• (2025). High-efficiency carbon perovskite solar cells via cathode interface engineering by using CuPc hole-transporting layers. ANGEW, 64(14), e202425191. (www)

  @article{ , abstract = {Carbon perovskite solar cells (C-PSCs) represent a promising photovoltaic (PV) technology that addresses the long-term operating stability needed to compete with commercial Si solar cells. However, the poor interface contacts between the carbon electrode and the perovskite result in a gap between C-PSC′s performances and state-of-the-art PSCs based on metallic back electrodes. In this work, Cu (II) phthalocyanine (CuPc) was rediscovered as an effective hole-transporting material (HTM) to be coupled with carbon electrodes. In particular, based on computational studies and VASP calculations, it is found that the tetragonal structure of CuPc could efficiently coordinated to perovskite (P) layer via N and Cu atoms to Pb and I atoms, respectively. By systematically optimizing the concentration of the CuPc HTL solution, and screening the coupling of CuPc HTL with two types of carbon electrodes, based on carbon black:graphite (C-G) mixture and reduced graphene oxide (RGO), respectively, a maximum power conversion efficiency (PCE) of 21.4 % (the mean PCE value of 18.57 %) has been achieved. In addition, our cells exhibit satisfactory stability under thermal aging at 85°C, showing less than 20% PCE loss after more than 200 hours. Furthermore, they maintain excellent shelf-life stability, with only 1.3% PCE loss over 20 days under ambient conditions (ISOS-D1). These findings represent a significant step forward in developing commercially competitive C-PSCs, as they combine both high PCE and stability.}, archive = {J_ANGEW}, author = {Zohreh Zaman and Hashem Shahroosvand and Sebastiano Bellani and Francesco Bonaccorso and Mohammad Khaja Nazeeruddin}, doi = {10.1002/anie.202425191}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-efficiency carbon perovskite solar cells via cathode interface engineering by using CuPc hole-transporting layers}, volume = {64}, year = {2025}, }
• (2025). Passivating lattice oxygen in ZnO nanocrystals to reduce its interactions with the key intermediates for a selective photocatalytic methane oxidation to methanol. ANGEW, 64(14), e202425186. (www)

  @article{ , abstract = {An inevitable overoxidation process is considered as one of the most challenging problems in the direct conversion of methane (CH 4 ) to methanol (CH 3 OH), which is limited by the uncontrollable cracking of key intermediates. Herein, we have successfully constructed a photocatalyst, the Fe-doped ZnO hollow polyhedron (Fe/ZnOHP), for the highly selective photoconversion of CH 4 to CH 3 OH under mild conditions. In situ experiments and density functional theory calculations confirmed that the introduction of Fe was able to decrease the energy level of the O 2 p orbital, which passivated the activity of lattice oxygen in ZnO nanocrystals. This passivation effect greatly weakened the interaction between *CH 3 and lattice oxygen, thus facilitating the conversion of *CH 3 O to *CH 3 intermediate rather than the direct desorption of *CH 3 O. As a result, Fe/ZnOHP exhibited excellent CH 3 OH generation rate (ca. 1009 μmol g cat −1 h −1 ) and selectivity (ca. 96 %) in the photocatalytic conversion of CH 4 at room temperature and low pressure.}, archive = {J_ANGEW}, author = {Ruimin Lan and Zhuofeng Hu and Haoran Liu and Kui Shen and Hui Wang and Tingting Hou and Yingwei Li}, doi = {10.1002/anie.202425186}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425186}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Passivating lattice oxygen in ZnO nanocrystals to reduce its interactions with the key intermediates for a selective photocatalytic methane oxidation to methanol}, volume = {64}, year = {2025}, }
• (2025). Engineering covalent aptamer chimeras for enhanced autophagic degradation of membrane proteins. ANGEW, 64(14), e202425123. (www)

  @article{ , abstract = {Targeted degradation of membrane proteins represents an attractive strategy for eliminating pathogenesis-related proteins. Aptamer-based chimeras hold great promise as membrane protein degraders, however, their degradation efficacy is often hindered by the limited structural stability and the risk of off-target effects due to the non-covalent interaction with target proteins. We here report the first design of a covalent aptamer-based autophagosome-tethering chimera (CApTEC) for the enhanced autophagic degradation of cell-surface proteins, including transferrin receptor 1 (TfR1) and nucleolin (NCL). This strategy relies on the site-specific incorporation of sulfonyl fluoride groups onto aptamers to enable the cross-linking with target proteins, coupled with the conjugation of an LC3 ligand to hijack the autophagy-lysosomal pathway for targeted protein degradation. The chemically engineered CApTECs exhibit enhanced on-target retention and improved structural stability. Our results also demonstrate that CApTECs achieve remarkably enhanced and prolonged degradation of membrane proteins compared to the non-covalent designs. Furthermore, the CApTEC targeting TfR1 is combined with 5-fluorouracil (5-FU) for synergistic tumor therapy in a mouse model, leading to substantial suppression of tumor growth. Our strategy may provide deep insights into the LC3-mdiated autophagic degradation, affording a modular and effective strategy for membrane protein degradation and precise therapeutic applications.}, archive = {J_ANGEW}, author = {Yang Shi and Yangfang Yun and Rong Wang and Zheng Liu and Zhenkun Wu and Yu Xiang and Jingjing Zhang}, doi = {10.1002/anie.202425123}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202425123}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering covalent aptamer chimeras for enhanced autophagic degradation of membrane proteins}, volume = {64}, year = {2025}, }
• (2025). Pyridoxal-inspired photo-decarboxylase catalysis: Photochemical decarboxylation of unprotected amino acids. ANGEW, 64(14), e202424843. (www)

  @article{ , abstract = {A photochemical organocatalytic method for the protodecarboxylation of unprotected amino acids is reported. Inspired by pyridoxal 5′-phosphate-dependent decarboxylase enzymes, the catalytic activation of amino acid substrates by 3-hydroxyisonicotinaldehyde enables a photochemical decarboxylation event, which can be leveraged in combination with a thiol co-catalyst. The necessary and sufficient structural features of the pyridoxal-like framework for photoactivity are determined using ultraviolet-visible absorption spectroscopy. A broad scope of unprotected amino acids can be decarboxylated in this system, with selectivity between multiple carboxylates realized on the possible basis of hyperconjugation. The ability to engage simple amino acids in decarboxylative functionalization at ambient conditions using a pyridoxal-mimicking organocatalyst enables new possibilities for the translation of biogenic amino acids into medicinally valuable amines.}, archive = {J_ANGEW}, author = {Dong-Hang Tan and Agniva Das and Vincent Huang and Timothy D. Schoch and Abubakar Lawal Mohammed and Jeffrey M. Lipshultz}, doi = {10.1002/anie.202424843}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424843}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pyridoxal-inspired photo-decarboxylase catalysis: Photochemical decarboxylation of unprotected amino acids}, volume = {64}, year = {2025}, }
• (2025). Nanoconfinement-enabled resistance to water matrix components for selective degradation of micropollutants. ANGEW, 64(14), e202424827. (www)

  @article{ , abstract = {Despite recent substantial advances in water treatment, the ability to selectively degrade trace micropollutants in real waters with complex matrix components remains a grand challenge. Here we report rational crafting of graphene oxide (GO)-wrapped defective TiO 2 composite catalysts that creates nanoscopic confinement over the TiO 2 surface within GO, thereby enabling the selective degradation of micropollutants through effectively excluding natural organic matter (NOM) and anions from the nanoconfined catalytic sites. In contrast to unconfined counterparts, the nanoconfined composite catalysts retain high degradation efficiency when exposed to various concentrations of NOM and anions, even in real water samples. Oxygen vacancies in TiO 2 promote electron separation and oxygen adsorption, leading to a 4.9-fold increase in hydroxyl radical concentration within the nanoconfined space compared to the bulk solution. In situ X-ray photoemission spectroscopy and Raman spectroscopy unveil the nanoconfined catalytic sites on the TiO 2 surface, where micropollutants smaller than the pores of GO are effectively degraded, while NOM with a larger size is excluded by GO. Furthermore, the formation of toxic disinfection byproducts is well controlled due to the exclusion of NOM. This work provides a simple yet viable strategy for designing 2D material-wrapped catalysts to selectively degrade target micropollutants in complex real waters.}, archive = {J_ANGEW}, author = {Shaoxiong He and Zhuofeng Hu and Chun He and Shuanghong Tian and Gangfeng Ouyang and Zhiqun Lin and Jingyun Fang}, doi = {10.1002/anie.202424827}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424827}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanoconfinement-enabled resistance to water matrix components for selective degradation of micropollutants}, volume = {64}, year = {2025}, }
• (2025). Amine-functionalized triazolate-based Metal–Organic frameworks for enhanced diluted CO2 capture performance. ANGEW, 64(14), e202424747. (www)

  @article{ , abstract = {Efficient CO 2 capture at concentrations between 400–2000 ppm is essential for maintaining air quality in a habitable environment and advancing carbon capture technologies. This study introduces NICS-24 (National Institute of Chemistry Structures No. 24), a Zn-oxalate 3,5-diamino-1,2,4-triazolate framework with two distinct square-shaped channels, designed to enhance CO 2 capture at indoor-relevant concentrations. NICS-24 exhibits a CO 2 uptake of 0.7 mmol/g at 2 mbar and 25 °C, significantly outperforming the compositionally related Zn-oxalate 1,2,4-triazolate – CALF-20 (0.17 mmol/g). Improved performance is attributed to amino-functions that enhance CO 2 binding and enable superior selectivity over N 2 and O 2 , achieving 8-fold and 30-fold improvements, respectively, in simulated CO 2 /N 2 and CO 2 /O 2 atmospheric ratios. In humid environments, NICS-24 retained structural integrity but exhibited an 85 % reduction in CO 2 capacity due to competitive water adsorption. Breakthrough sorption experiments, atomistic NMR analysis, and DFT calculations revealed that water preferentially adsorbs over CO 2 due to strong hydrogen-bonding interactions within the framework. Gained understanding of the interaction between CO 2 and H 2 O within the MOF framework could guide the modification via rational design with improved performance under real-world conditions.}, archive = {J_ANGEW}, author = {Klara Klemenčič and Andraž Krajnc and Andreas Puškarić and Matej Huš and Dana Marinič and Blaž Likozar and Nataša Zabukovec Logar and Matjaž Mazaj}, doi = {10.1002/anie.202424747}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424747}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amine-functionalized triazolate-based Metal–Organic frameworks for enhanced diluted CO2 capture performance}, volume = {64}, year = {2025}, }
• (2025). Synthesis and reactivity of six-membered cyclic diaryl λ3-bromanes and λ3-chloranes. ANGEW, 64(14), e202424559. (www)

  @article{ , abstract = {Despite the remarkable advancements in hypervalent iodine chemistry, exploration of bromine and chlorine analogues remains in its infancy due to their difficult synthesis. Herein, we introduce six-membered cyclic λ 3 -bromanes and λ 3 -chloranes. Through single-crystal X-ray structural analyses and conformational studies, we delineate the crucial bonding patterns pivotal for the thermodynamic stability of these compounds. Notably, these investigations reveal pronounced π–π stacking phenomena within the crystal lattice of hypercoordinated bromine(III) and chlorine(III) species. Their reactivity profile is explored as they are radical precursors or electrophilic reagents in metal-free intermolecular biaryl couplings, O - and S -arylations, and Cu(I)-promoted intramolecular biaryl couplings which is complementary to the known reactivity of five-membered bromanes and chloranes. Mechanistic insights are provided, elucidating the pathways governing their reactivity and underscoring the potential in organic synthesis.}, archive = {J_ANGEW}, author = {Dhananjay Bhattacherjee and Benson M. Kariuki and Bruno A. Piscelli and Rodrigo A. Cormanich and Thomas Wirth}, doi = {10.1002/anie.202424559}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424559}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and reactivity of six-membered cyclic diaryl λ3-bromanes and λ3-chloranes}, volume = {64}, year = {2025}, }
• (2025). Superconjugated anthraquinone carbonyl-based covalent organic framework as anode material for high-performance aqueous ammonium-ion batteries. ANGEW, 64(14), e202424494. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have recently been emerged as promising anode candidates for aqueous ammonium ion batteries (AAIBs), but suitable COFs need to be developed and the energy storage mechanisms need to be further investigated. Here we report an anthraquinone carbonyl-containing COF as anode for AAIBs, which exhibits a high specific capacity of 141 mAh g −1 at 0.1 A g −1 and good cycling stability with 90 % retention after 8000 cycles at 6 A g −1 . We find that the anthraquinone carbonyls (denoted as C=O 1 ) with superconjugated structure in the COF can form hydrogen bonds with NH 4 + ions, thus serving as optimal sites and providing the major contribution to NH 4 + ion storage, whereas another type of carbonyls (denoted as C=O 2 ) in the same COF suffers from enol-keto tautomerism, which prevents the formation of hydrogen bonds and is therefore unfavourable for NH 4 + ion storage. This is further verified by the theoretical calculations where the hydrogen bonding rate of C=O 1 groups is much faster than that of C=O 2 . This work not only provides insights into understanding the mechanism of NH 4 + ion storage, but also offers new ideas for the design of advanced COF-based materials for AAIBs.}, archive = {J_ANGEW}, author = {Jiahui Liu and Keyan Guo and Wen Guo and Jiaqi Chang and Yongsheng Li and Fuxi Bao}, doi = {10.1002/anie.202424494}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424494}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Superconjugated anthraquinone carbonyl-based covalent organic framework as anode material for high-performance aqueous ammonium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Super strong bonding at the interface between ETL and perovskite for robust flexible optoelectronic devices. ANGEW, 64(14), e202424483. (www)

  @article{ , abstract = {Organic-inorganic hybrid perovskites have demonstrated great potential for flexible optoelectronic devices due to their superior optoelectronic properties and structural flexibility. However, mechanical deformation-induced cracks at the buried interface and delamination from the substrate severely constrain the optoelectronic performance and device lifespan. Here, we design a two-site bonding strategy aiming to reinforce the mechanical stability of the SnO 2 /perovskite interface and perovskite layer using a multifunctional organic salt, 4-(trifluoromethoxy)phenylhydrazine hydrochloride (TPH). This approach significantly enhances the bonding at the buried interface between the electron transport layer and perovskite layer, which is demonstrated by TPH-modified SnO 2 /perovskite interface remaining intact after 10,000 bending cycles. Meanwhile, TPH mitigates void formation, enhances perovskite crystallinity at the buried interface, and inhibits ion migration inside the devices. Furthermore, incorporating TPH in perovskite bulk decreases the nucleation activation energy and accelerates nucleation, leading to high-quality perovskite film. Consequently, power conversion efficiencies (PCEs) of 21.64 % and 23.61 % are achieved for target flexible and rigid perovskite solar cells, respectively. The target flexible device retained 92.3 % of its initial PCE after 25,000 bending cycles. This approach provides a robust solution for enhancing the mechanical durability of flexible perovskite optoelectronic devices.}, archive = {J_ANGEW}, author = {Jingjing Hui and Jun Zhan and Jinxia Zhang and Xiaowen Gao and Cong Wang and Yiyi Li and Jin Li and Kewei Wang and Zeyu He and Qi Li and Yi Wang and Yongqi Liang and Langxing Chen and Yukui Zhang and Dongsheng Xu}, doi = {10.1002/anie.202424483}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424483}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Super strong bonding at the interface between ETL and perovskite for robust flexible optoelectronic devices}, volume = {64}, year = {2025}, }
• (2025). Spontaneous hydrogen production coupled with glucose valorization through modulating au-pt coordination on ultrathin Au3Pt twin nanowires. ANGEW, 64(14), e202424476. (www)

  @article{ , abstract = {Organics electrooxidation coupled hydrogen production has attracted increasing attention due to the low operation voltage. Nevertheless, the spontaneous production of hydrogen coupled with organics valorization remains challenging. Herein, we develop ultrathin Au / Pt twin nanowire (NW) catalysts for both electrochemical glucose oxidation and hydrogen evolution reaction towards a spontaneous hydrogen production system. The more Pt−Au coordination and the localized tensile strain generated on twin boundaries of Au 3 Pt NWs facilitate the selective glucose electro-oxidation to gluconic acid (GNA) compared to Pt NWs (a low onset potential of 0.07 V RHE and selectivity >90 %). In situ spectroscopy and theoretical calculations reveal that Au 3 Pt NWs could reduce the energy barriers for GNA generation and alleviate the poisoning of Pt sites via a ′Pt-to-Au site transfer′ mechanism, which facilitates the desorption of strongly absorbed gluconolactone. Therefore, the asymmetric cell equipped with Au 3 Pt NWs catalysts realizes the spontaneous hydrogen production and glucose valorization with a peak power of 50 mW, which outputs the voltage of 0.24 V at 50 mA cm −2 , outperforming the state-of-the-art electrolyzers for hydrogen production. The production of 1 kg H 2 of the device is accompanied with $64.2 valorization of the anode product ($1200 ton −1 for GNA), and 5.36 kW h of generated electricity.}, archive = {J_ANGEW}, author = {Hao Shi and Tanyuan Wang and Zijie Lin and Shuxia Liu and Xuan Liu and Ruixin Zhou and Zhao Cai and Yunhui Huang and Qing Li}, doi = {10.1002/anie.202424476}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424476}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spontaneous hydrogen production coupled with glucose valorization through modulating au-pt coordination on ultrathin Au3Pt twin nanowires}, volume = {64}, year = {2025}, }
• (2025). Easily water-synthesisable iron-chloranilate frameworks as high energy and high-power cathodes for sustainable alkali-ion batteries. ANGEW, 64(14), e202424416. (www)

  @article{ , abstract = {Achieving high battery performance from low-cost, easily synthesisable electrode materials is crucial for advancing energy storage technologies. Metal–organic frameworks (MOFs) combining inexpensive transition metals and organic ligands are promising candidates for high-capacity cathodes. Iron-chloranilate-water frameworks are herein reported to be produced in aqueous media under mild conditions. Removal of reticular water from known [Fe 2 (CAN) 3 (H 2 O) 4 ] ⋅ 4H 2 O yields a new supramolecular metal–organic framework (SMOF), [Fe 2 (CAN) 3 (H 2 O) 4 ]. Removing coordination water, a new 2D honeycomb-like MOF forms, Fe 2 (CAN) 3 , stable without counterions and solvent. This MOF adopts the unusual ABC layer-stacking, as determined using a combination of ab initio random structure searching, electron diffraction, and Rietveld refinement of powder XRD data. Magnetometry, Mossbauer and Raman spectroscopy confirm that all three [Fe 2 (CAN) 3 (H 2 O) x ]⋅ y H 2 O phases contain HS-Fe 3+ and CAN 2− , with magnetic ordering temperatures increasing (5→20 K) as the Fe−CAN connectivity increases. The SMOF and MOF show reversible (de)insertion of >4Li + /f.u. at average 2,59 V and 2,76 V vs Li + /Li, respectively. [Fe 2 (CAN) 3 ] achieves 146 mAh/g at 1 C, thus specific energy (563 Wh/kg) and power (446 W/kg) in Li half-cells competitive with conventional LiFePO 4 (~580 Wh/kg and ~450 W/kg). Beyond Li, [Fe 2 (CAN) 3 ] delivers 394 Wh/kg and 421 Wh/kg, for Na and K half-cells respectively, becoming a competitive cathode for sustainable batteries.}, archive = {J_ANGEW}, author = {Víctor Durán-Egido and James P. Darby and Matthew J. Cliffe and José S. Garitaonandia and Paloma Grande-Fernández and Andrew J. Morris and Javier Carretero-González and Elizabeth Castillo-Martínez}, doi = {10.1002/anie.202424416}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Easily water-synthesisable iron-chloranilate frameworks as high energy and high-power cathodes for sustainable alkali-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Carving Metal–Organic–Framework glass based Solid–State electrolyte via a Top–Down strategy for Lithium–Metal battery. ANGEW, 64(14), e202424288. (www)

  @article{ , abstract = {Traditional polymer solid electrolytes (PSEs) suffer from low ions conductivity, poor kinetics and safety concerns. Here, we present a novel porous MOF glass gelled polymer electrolyte (PMG-GPE) prepared via a top-down strategy, which features a unique three-dimensional interconnected graded-aperture structure for efficient ions transport. Comprehensive analyses, including time-of-flight secondary ion mass spectrometry (TOF-SIMS), Solid-state 7 Li magic-angle-spinning nuclear magnetic resonance (MAS NMR), Molecular Dynamics (MD) simulations, and electrochemical tests, quantify the pore structures, revealing their relationship with ions conductivity that increases and then decreases as macropore proportion rises. The introduced dispersed macropores (17 % fraction) can serve as bridges, connecting adjacent transport units to accelerate ions transport. Taking advantage of the cross-linked ion-conductive paths constructed by hierarchical pore structures, the PMG-GPE achieves a high ions conductivity of 1.9 mS cm −1 . Additionally, the robust mechanical properties of PMG-GPE effectively suppress dendrite growth and penetration, outperforming crystal MOF-based electrolytes. The prepared Li symmetric batteries with PMG-GPE demonstrate a high critical current density of 5.1 mA cm −2 (two times higher than crystal MOF-electrolytes) and stable cycling for over 6000 hours without short circuits. Furthermore, a Li/PMG-GPE/LFP half-cell exhibits exceptional capacity retention of 83.12 % after 1400 cycles. These findings highlight the potential of structural design in advancing PSE performance, offering a promising pathway for the commercialization of high-performance solid-state batteries.}, archive = {J_ANGEW}, author = {Yang Xiang and Ning Yu and Jianbo Li and Huixiang Xu and Shuang Chen and Yufan Xia and Zhen Luo and Xu Li and Zhu Liu and Maowen Xu and Yinzhu Jiang and Xuan Zhang}, doi = {10.1002/anie.202424288}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424288}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carving Metal–Organic–Framework glass based Solid–State electrolyte via a Top–Down strategy for Lithium–Metal battery}, volume = {64}, year = {2025}, }
• (2025). Ligand engineering regulation toward zn ions and zn substrate for all-climate zn metal batteries. ANGEW, 64(14), e202424272. (www)

  @article{ , abstract = {The regulation of artificial interphase for advanced Zn anode is an effective solution to achieve superior electrochemical performance for aqueous batteries. However, the deployment of atomically precise architectures and ligand engineering to achieve functionalization-oriented regulatory screening is lacking, which is hindered by higher requirements for synthetic chemistry and structural chemistry. Herein, we have first performed ligand engineering which selected zinc ion trapping ligands (−CH 3 ) based on the coordination effect, and zinc substrate binding ligands (−N=N−C 6 H 5 ) based on the electrostatic interaction. Correspondingly, octa nuclear Zn(II)-Siloxane-PhPz/BiPhPz/TriPhPz Cluster ( OZSPC / OZSBPC / OZSTPC ) are accurately synthesized, and OZSBPC is verified to serve as the most suitable artificial interphase via balancing the interactions with both Zn 2+ and Zn substrate (“Zn−Zn effect”). Consequently, at −30 °C, the assembled OZSBPC -Zn symmetric cells run for 3000 h and the assembled full cells with OZSBPC -Zn anode could be stable for 10,000 cycles. The pouch cells using OZSBPC -Zn anode deliver a reversible capacity of ~1.2 Ah and the energy density of 41 Wh kg total −1 with excellent cycling performance. The successful structural design of OZSBPC explores a novel well-defined structural design concept as one criterion for artificial interface as well as motivates batteries systems to meet the requirements of industrialization.}, archive = {J_ANGEW}, author = {Zhengchunyu Zhang and Tianyang Xu and Kun Xu and Zihan Jiang and Di Sun and Cheng Wang and Jinkui Feng and Baojuan Xi and Shenglin Xiong}, doi = {10.1002/anie.202424272}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424272}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand engineering regulation toward zn ions and zn substrate for all-climate zn metal batteries}, volume = {64}, year = {2025}, }
• (2025). Lowering linker symmetry to access zirconium Metal–Organic frameworks for inverse Alkane/Alkene separations. ANGEW, 64(14), e202424260. (www)

  @article{ , abstract = {Enriching the structural diversity of metal–organic frameworks (MOFs) is of great importance in developing functional porous materials with specific properties. New MOF structures can be accessed through the rational design of organic linkers with diverse geometric conformations, and their structural complexity can be enhanced by choosing linkers with reduced symmetry. Herein, a series of Zr-based MOFs with unprecedented topologies were developed through a linker desymmetrization and conformation engineering approach. A tritopic carboxylate linker with reduced symmetry and flexible triangular geometry was designed to construct three Zr-based MOFs (denoted as NU-57, NU-58, and NU-59) by modulating synthetic conditions. Notably, the conformational flexibility and reduced symmetry of the linker generated two unprecedented topologies in NU-58 and NU-59. Furthermore, solvent removal in NU-58 via thermal activation process produced missing linker defects. Finally, the adsorption behavior of these MOFs toward alkanes and alkenes was studied to gain insights into their structure–property relationships, which demonstrated that NU-57 and NU-58 exhibit unusual reverse selectivity for alkanes in alkane/alkene separations. Overall, this work highlights the rational design of linkers using a desymmetrization strategy as a powerful method to enrich the structural diversity of MOFs and to access novel MOFs with unique properties.}, archive = {J_ANGEW}, author = {Chenghui Zhang and Filip Formalik and Daofei Lv and Fanrui Sha and Kent O. Kirlikovali and Xiaoliang Wang and Xianhui Tang and Shengyi Su and Haomiao Xie and Yongwei Chen and Zhibo Li and Randall Q. Snurr and Omar K. Farha}, doi = {10.1002/anie.202424260}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424260}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lowering linker symmetry to access zirconium Metal–Organic frameworks for inverse Alkane/Alkene separations}, volume = {64}, year = {2025}, }
• (2025). Interstitial doping in ultrafine nanocrystals for efficient and durable water splitting. ANGEW, 64(14), e202424195. (www)

  @article{ , abstract = {Transition metal-based catalysts with high efficiency and stability for overall water splitting (OWS) offer significant potential for reducing green hydrogen production costs. Utilizing sputtering deposition technology, we propose a deposition-diffusion strategy to fabricate heterojunction coatings composed of ultrafine FeCoNi-C-N transition metal interstitial solid solution (TMISS) nanocrystals and amorphous nitrided carbon (NC) on the pre-deposited NC micro column arrays. The diffusion of C and N atoms results in the formation of uniformly distributed TMISS nanocrystals, with an average diameter of ~1.9 nm, thus maximizing atomic utilization. The unique crystalline-amorphous heterojunction interface enhances electrocatalytic stability. Furthermore, the electronic regulation of metal sites by interstitial C and N atoms not only optimizes the adsorption-dissociation process in hydrogen evolution reaction (HER), but also accelerates the surface reconstruction of hydroxyl oxides to enhance the oxygen evolution reaction (OER) activity. As a result, the as-prepared coating achieved overpotentials of only 62 mV and 237 mV for the HER and OER at 10 mA cm −2 in alkaline electrolytes, and exhibited excellent OWS performance and long-term stability at high current densities. This work presents a new perspective for synthesizing TMISS nanocrystals and promotes their application in bifunctional electrocatalysts.}, archive = {J_ANGEW}, author = {Minming Jiang and Jiang Xu and Yujie Chen and Luqi Wang and Qi Zhou and Paul Munroe and Linlin Li and Zong-Han Xie and Shengjie Peng}, doi = {10.1002/anie.202424195}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424195}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interstitial doping in ultrafine nanocrystals for efficient and durable water splitting}, volume = {64}, year = {2025}, }
• (2025). Regulating water molecules via bioinspired covalent organic framework membranes for zn metal anodes. ANGEW, 64(14), e202424184. (www)

  @article{ , abstract = {The Zn metal anode in aqueous zinc-ion batteries (AZIBs) faces daunting challenges including undesired water-induced parasitic reactions and sluggish ion migration kinetics. Herein, we develop three-dimensional covalent organic framework (COF) membranes with bioinspired ion channels toward stabilized Zn anodes. These COFs, featured by zincophilic pyridine-N sites, enable effective regulation of water molecules at the anode-electrolyte interphase. Systematic experimental analysis and theoretical simulations reveal the optimized COF-320N membrane functions as ion pumps, accordingly facilitating Zn 2+ transport and inhibiting direct contact between Zn anode and free water molecules. Consequently, the bio-inspired strategy achieves improved Zn 2+ transference number (0.61), rapid de-solvation kinetics, and suppressed hydrogen evolution. The assembled Zn||MnO 2 pouch cell integrated with COF-320N membrane exhibits favorable electrochemical performances. Such a bioinspired concept for optimizing Zn anodes opens new pathways in developing advanced energy storage devices.}, archive = {J_ANGEW}, author = {Sida Zhang and Jiashu Chen and Weigen Chen and Yiwen Su and Qianzhi Gou and Ruduan Yuan and Ziyi Wang and Kaixin Wang and Wentao Zhang and Xiqian Hu and Zhixian Zhang and Pinyi Wang and Fu Wan and Jie Liu and Beibei Li and Yifei Wang and Guangping Zheng and Meng Li and Jingyu Sun}, doi = {10.1002/anie.202424184}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424184}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating water molecules via bioinspired covalent organic framework membranes for zn metal anodes}, volume = {64}, year = {2025}, }
• (2025). COF-assisted construction of steric mass-charge channels to boost activity for high-performance fuel cells. ANGEW, 64(14), e202424179. (www)

  @article{ , abstract = {The two-dimensional lamellar materials disperse platinum sites and minimize noble-metal usage for fuel cells, while mass transport resistance at the stacked layers spurs device failure with a significant performance decline in membrane electrode assembly (MEA). Herein, we implant porous and rigid sulfonated covalent organic frameworks (COF) into the graphene-based catalytic layer for the construction of steric mass-charge channels, which highly facilitates the activity of oxygen reduction reactions in both the rotating disk electrode (RDE) measurements and MEA device tests. Specifically, the normalized mass activity is remarkably boosted by 3.7 times to 1.56 A mg pt −1 after additions of suitable COF modifications in the RDE tests. Especially, an excellent maximum power density of 1.015 W cm −2 is realized on the MEA in H 2 /Air condition, representing a 22 % improvement through such constructions of steric mass-charge channels. Meanwhile, the open-circuit voltage of fuel cells demonstrates only 0.8 % reductions after 10,000 cycles of stability tests. We further extended such methodology of constructing mass-charge channels to granular PtCo and commercial Pt/C catalysts, which demonstrates a significant impetus for stimulating the catalytic activity in fuel cells.}, archive = {J_ANGEW}, author = {Guobin Wen and Liancheng Sun and Yanzhou Qin and Shengnan Liu and Luyao Ma and Ningce Zhang and Shuxuan Liu and Yan Yin and Bohua Ren and Shuangyin Wang}, doi = {10.1002/anie.202424179}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {COF-assisted construction of steric mass-charge channels to boost activity for high-performance fuel cells}, volume = {64}, year = {2025}, }
• (2025). Distinct valence states of the [4Fe4S] cluster revealed in the hydrogenase CrHydA1. ANGEW, 64(14), e202424167. (www)

  @article{ , abstract = {Iron-sulfur clusters play a crucial role in electron transfer for many essential enzymes, including [FeFe]-hydrogenases. This study focuses on the [4Fe4S] cluster ([4Fe] H ) of the minimal [FeFe]-hydrogenase from Chlamydomonas reinhardtii ( Cr HydA1) and employs advanced spectroscopy, site-directed mutagenesis, molecular dynamics simulations, and QM/MM calculations. We provide insights into the complex electronic structure of [4Fe] H and its role in the catalytic reaction of Cr HydA1, serving as paradigm for understanding [FeFe]-hydrogenases. We identified at least two distinct species within the apo-form of Cr HydA1, designated 4Fe−R and 4Fe−A, with unique redox potentials and pH sensitivities. Our findings revealed that these species arise from a complex interplay of structural heterogeneity and valence isomer rearrangements, influenced by second-sphere residues. We propose that the interconversion between 4Fe−R and 4Fe−A could provide control over electron transfer in the absence of accessory FeS clusters typically found in other [FeFe]-hydrogenases. The insights gained from this study not only enhance our understanding of [FeFe]-hydrogenases but also provide a crucial foundation for future investigations into analysis of other FeS clusters across diverse biological systems.}, archive = {J_ANGEW}, author = {Melanie Heghmanns and Shalini Yadav and Sergius Boschmann and Victor R. Selve and Astrit Veliju and Claudia Brocks and Thomas Happe and Dimitrios A. Pantazis and Müge Kasanmascheff}, doi = {10.1002/anie.202424167}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424167}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Distinct valence states of the [4Fe4S] cluster revealed in the hydrogenase CrHydA1}, volume = {64}, year = {2025}, }
• (2025). Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells. ANGEW, 64(14), e202424060. (www)

  @article{ , abstract = {Fluorogenic RNA aptamers have revolutionized the visualization of RNAs within complex cellular processes. A representative category of them employs the derivatives of green fluorescent protein chromophore, 4-hydroxybenzlidene imidazolinone (HBI), as chromophores. However, the structural homogeneity of their chromophoric backbones causes severe cross-reactivity with other homologous chromophores. This limitation impairs their multiplexing capabilities, which are essential for the simultaneous visualization of multiple RNA species in live cells. Herein, we rationally designed a series of red-shifted chromophores and employed SELEX-independent engineering to develop a novel fluorogenic RNA aptamer, mSquash. mSquash displays specific and intense fluorescence upon binding with our red-shifted chromophore DFHBFPD (Ex/Em=501/624 nm). The mSquash/DFHBFPD allows orthogonal imaging of selected RNA targets alongside the established Broccoli/DFHBI-1T (Ex/Em=472/501 nm), facilitating multiplexed live cell imaging of various targets. Moreover, we expanded the application of fluorescent RNA to photoactive imaging by constructing two genetically encoded photoactivatable fluorescent RNAs for the first time. This innovative approach allows photoactivatable control of fluorescent RNAs via specific light wavelengths (365 nm and 450 nm), enabling spatiotemporal dual-color imaging of RNAs in live cells. Our findings represent a significant advancement in fluorescent RNA-based orthogonal imaging and spatiotemporal analysis of RNAs.}, archive = {J_ANGEW}, author = {Peng Yin and Chunzheng Huang and Li Zhang and Zhenzhen Li and Caijun Zhong and Shi Kuang and Chunyang Lei and Yan Huang and Zhou Nie}, doi = {10.1002/anie.202424060}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424060}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells}, volume = {64}, year = {2025}, }
• (2025). Two-dimensional layered germanium iodide perovskite ferroelectric semiconductors. ANGEW, 64(14), e202424058. (www)

  @article{ , abstract = {The discovery of ferroelectricity in two-dimensional (2D) semiconductors has opened a new and exciting chapter in next-generation electronics and spintronics due to their lattice-dimensionality-induced unique behaviors and fascinating functionalities brought by spontaneous polarization. The emerging layered halide perovskites with 2D lattices provide a great platform for generating reduced symmetry and low-dimensional ferroelectricity. Herein, inspired by the approach of reduced lattice dimensionality, a series of 2D layered germanium iodide perovskite ferroelectric semiconductors A 2 CsGe 2 I 7 [where A=PA (propylammonium), BA (butylammonium) and AA (amylammonium)] was firstly developed, which demonstrates remarkable semiconducting features including narrow direct band gap (~1.8 eV) and high conductivity over 32.23 nS/cm. Emphatically, these layered germanium iodide perovskites manifest large in-plane ferroelectric polarization over ~10.0 μC/cm 2 , mainly attributed to the large off-centering ion displacement induced by stereo-active lone-pairs of Ge 2+ . More specifically, in contrast to three-dimensional ferroelectric CsGeI 3 , the representative 2D layered BA 2 CsGe 2 I 7 manifests a superior polarization-sensitive bulk photovoltaic effect with a polarization ratio of 1.68 and high short circuit current density up to 81.25 μA/cm 2 , which is superior to those of reported layered halide perovskite ferroelectrics. This work provides an exciting pathway for the development of 2D ferroelectric semiconductors as well as sheds light on their further applications in photoelectronic fields.}, archive = {J_ANGEW}, author = {Xiaoqi Li and Jie Bie and Qianxi Wang and Kai Li and Yicong Lv and Xiantan Lin and Shuang Chen and Zhihua Sun and Xitao Liu and Junhua Luo}, doi = {10.1002/anie.202424058}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424058}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-dimensional layered germanium iodide perovskite ferroelectric semiconductors}, volume = {64}, year = {2025}, }
• (2025). Amorphization stabilizes te-based aqueous batteries via confining free water. ANGEW, 64(14), e202424056. (www)

  @article{ , abstract = {Tellurium (Te), with its rich valence states (−2 to +6), could endow aqueous batteries with potentially high specific capacity. However, achieving complete and stable hypervalent Te 0 /Te 4+ electrochemistry in an aqueous environment poses significant challenges, owing to the sluggish reduction kinetics, easy dissolution of Te 4+ species, and a controversial energy storage mechanism. Herein, we demonstrate a crystallographic regulation strategy for robust aqueous Te redox electrochemistry. With strong hydrogen bonding, NH 4 Ac confines free water, prompting the amorphization of TeO 2 (a-TeO 2 ). In situ synchrotron characterization, spectroscopy analysis, electrochemical evaluation, and theoretical calculations reveal a specific 4 e − solid-solid transition pathway (Te to a-TeO 2 ) with accelerated diffusion and charge transfer kinetics, attributed to a closer unoccupied electron orbital to the Fermi level and a reduced water desorption energy barrier in a-TeO 2 . Impressively, the a-TeO 2 /Te redox exhibits a high reversible capacity of 834 mAh g −1 (99% of Te redox utilization), superior rate performance (644 mAh g −1 at 10 A g −1 ), and an ultralong lifespan (over 3000 cycles). These findings prove a new tactic to advance aqueous Te redox electrochemistry toward high-energy aqueous batteries.}, archive = {J_ANGEW}, author = {Yanyan Zhang and Wanhai Zhou and Boya Wang and Tengsheng Zhang and Xiaoyu Yu and Xinran Li and Gaoyang Li and Hongrun Jin and Minghua Chen and Wei Li and Dongyuan Zhao and Xin Liu and Dongliang Chao}, doi = {10.1002/anie.202424056}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424056}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amorphization stabilizes te-based aqueous batteries via confining free water}, volume = {64}, year = {2025}, }
• (2025). Modulating perovskite surface energetics through tuneable ferrocene interlayers for high-performance perovskite solar cells. ANGEW, 64(14), e202424041. (www)

  @article{ , abstract = {Achieving rational control over chemical and energetic properties at the perovskite/electron transport layer (ETL) interface is crucial for realizing highly efficient and stable next-generation inverted perovskite solar cells (PSCs). To address this, we developed multifunctional ferrocene (Fc)-based interlayers engineered to exhibit adjustable passivating and electrochemical characteristics. These interlayers are designed to reduce non-radiative recombination, and to modulate the work function (WF) and uniformity of the perovskite surface, thereby enhancing device performance. The key role played by the highest occupied molecular orbital energies ( E HOMO ) of the Fc compounds relative to the perovskite valance band maximum ( E VBM ) is revealed. This relationship is pivotal in controlling band bending and optimizing charge extraction. Notably, the conformationally flexible and more easily oxidized ferrocenyl-bis-furyl-2-carboxylate ( 2 ) is found to more effectively bind with undercoordinated Pb 2+ surface sites and modulate interfacial energetics, resulting in inverted PSCs achieving champion efficiencies of 25.16 %. These cells also displayed excellent stability, retaining >92 % of the initial efficiency after 1,000 h of maximum power point operation at 65 °C. By correlating the broadly tunable Fc- E HOMO with a decreased and homogenized perovskite surface WF, our work advances our understanding of Fc-based interlayers and opens new pathways for their application in high-efficiency solar technologies.}, archive = {J_ANGEW}, author = {Francesco Vanin and William D. J. Tremlett and Danpeng Gao and Qi Liu and Bo Li and Shuai Li and Jianqiu Gong and Xin Wu and Zhen Li and Ryan K. Brown and Liangchen Qian and Chunlei Zhang and Xianglang Sun and Xintong Li and Xiao Cheng Zeng and Zonglong Zhu and Nicholas J. Long}, doi = {10.1002/anie.202424041}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424041}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating perovskite surface energetics through tuneable ferrocene interlayers for high-performance perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Defect-induced electron localization promotes D2O dissociation and nitrile adsorption for deuterated amines. ANGEW, 64(14), e202424039. (www)

  @article{ , abstract = {Electrochemical reductive deuteration of nitriles is a promising strategy for synthesizing deuterated amines with D 2 O as the deuterated source. However, this reaction suffers from high overpotentials owing to the sluggish D 2 O dissociation kinetics and high thermodynamic stability of the C≡N triple bond. Here, low-coordinated copper (LC−Cu) is designed to decrease the overpotential for the electrosynthesis of the precursor of Melatonin-d 4 , 5-methoxytryptamine- d 4 , by 100 mV with a 68 % yield (Faradaic efficiency), which is 4 times greater than that of high-coordinated copper (HC−Cu). The low coordinated sites induced an enrichment of electrons to concentrate K + ions hydrated deuterium water (K⋅D 2 O) and decrease the energy of the Volmer step via the polarization effect, leading to a continuous supplementation of *D for the reductive deuteration of nitriles. Moreover, the enhanced local electric field changes the adsorption configuration of nitriles from a semibridge model to a flat model, leading to faster reduction kinetics of nitriles with a high reaction rate at lower potentials. High deuterium incorporation, a wide substrate scope, and easy gram-scale synthesis over LC−Cu at 300 mA rationalize the design concept. Furthermore, the enhanced antitumor and antioxidation effects of Melatonin-d 4 highlight the great promise of deuterated drugs.}, archive = {J_ANGEW}, author = {Rui Li and Meng He and Chuanqi Cheng and Fanpeng Chen and Lijun Yang and Jian-Zhong Cui and Cuibo Liu and Bin Zhang}, doi = {10.1002/anie.202424039}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424039}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Defect-induced electron localization promotes D2O dissociation and nitrile adsorption for deuterated amines}, volume = {64}, year = {2025}, }
• (2025). Dendritic platinum nanoparticles shielded by pt-S PEGylation as intracellular reactors for bioorthogonal uncaging chemistry. ANGEW, 64(14), e202424037. (www)

  @article{ , abstract = {Beyond their classical role as cytotoxics, Platinum (Pt) coordination complexes recently joined the selected group of transition metals capable of performing bioorthogonal reactions in living environments. To minimize their reactivity towards nucleophiles, which limit their catalytic performance, we investigated the use of Pt(0) with different forms, sizes and surface functionalization. We report herein the development of PEGylated Pt nanodendrites with the capacity to activate prodyes and prodrugs in cell culture and in vivo. Their dendritic morphology together with their surface shielding through Pt−S-bonded PEGylation synergistically contributed to create catalytic nanoreactors compatible with the highly-crowded and reductive environment of the cell cytoplasm, thereby facilitating in situ bioorthogonal drug uncaging in cancer cells in 2D and 3D culture, including in microfluidic systems, and xenografted in zebrafish.}, archive = {J_ANGEW}, author = {Jose I. Garcia-Peiro and M. Carmen Ortega-Liebana and Catherine Adam and Álvaro Lorente-Macías and Jana Travnickova and E. Elizabeth Patton and Paula Guerrero-López and J. Manuel Garcia-Aznar and Jose L. Hueso and Jesus Santamaria and Asier Unciti-Broceta}, doi = {10.1002/anie.202424037}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424037}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dendritic platinum nanoparticles shielded by pt-S PEGylation as intracellular reactors for bioorthogonal uncaging chemistry}, volume = {64}, year = {2025}, }
• (2025). Dual active site covalent organic framework anode enables stable aqueous proton batteries. ANGEW, 64(14), e202424025. (www)

  @article{ , abstract = {Aqueous proton batteries (APBs) have attracted increasing interest owing to their potential for grid-scale energy storage with extraordinary sustainability and excellent rate abilities. However, there are limited anode materials and it remains a great challenge to effectively balance capacity and cycling performance. Here, we report a covalent organic framework containing C=O and C=N dual active sites (TABQ-COF) as a high-capacity and long-cycle anode for proton batteries. The proton storage ability of the dual active sites and the up to nine proton redox chemistry mechanisms for each repetitive unit have been demonstrated by experiments and density functional theory calculations. The insoluble TABQ-COF electrode displayed a remarkably high specific capacity of 401 mAh g −1 , outstanding cycling stability (100 % capacity retention after 7500 cycles) and high rate performance (90 mAh g −1 at 50 A g −1 ). When coupling with a MnO 2 cathode, the constructed TABQ-COF//MnO 2 battery achieves a reversible capacity of 247 mAh g −1 at 5 A g −1 , with a remarkable capacity retention of 100 % over 10000 cycles. Furthermore, the TABQ-COF//MnO 2 battery can operate well and shows high capacity and cycle stability in a frozen electrolyte at −40°C, implying great potential for energy storage at extreme temperatures.}, archive = {J_ANGEW}, author = {Qi Zhao and Youxuan Ni and Yong Lu and Weiwei Xie and Haixia Li and Zhenhua Yan and Kai Zhang and Yixin Li and Jun Chen}, doi = {10.1002/anie.202424025}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202424025}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual active site covalent organic framework anode enables stable aqueous proton batteries}, volume = {64}, year = {2025}, }
• (2025). Unlocking advanced architectures of single-crystal Metal–Organic frameworks. ANGEW, 64(14), e202423939. (www)

  @article{ , abstract = {The synthesis of metal–organic frameworks (MOFs) with diverse geometries has captivated considerable interest due to their manifestation of novel and extraordinary properties. While much progress has been made in shaping regular polyhedral single-crystal MOFs, the creation of more complex, topologically intricate nanostructures remains a largely unexplored frontier. Here, we present a refined site-specific anisotropic assembly and etching co-mediation approach to fabricate a series of hierarchical MOF nanohybrids and single-crystal MOFs. This approach yields ZIF-8&mSiO 2 nanohybrids with diverse topologies, alongside derived single-crystal MOF nanoparticles exhibiting intricate morphologies such as hexapods, nested nanocages, and octopods. Our method involves the selective growth of six mSiO 2 nanoplates on the {100} facets of ZIF-8 nanocubes, forming the cubic-shaped ZIF-8&mSiO 2 nanohybrids, with the concurrent etching of the {110} facets of initial ZIF-8 nanocubes. By fine-tuning this balance between the growth and etching, we achieved precise morphological control, transforming cubic nanohybrids into intricate hexapods nanohybrids. Additionally, secondary epitaxial growth of homo- or hetero-MOFs on these hybrids led to ZIF-8&mSiO 2 &MOF composites with six mSiO 2 inlays. Finally, selective alkaline etching of the mSiO 2 compartments result in single-crystal MOF nanoparticles with unprecedented and sophisticated morphologies, such as hexapods, nested nanocages, octopods. This work advances the field of MOF nanostructure design, opening new avenues for the development of sophisticated, multifunctional materials.}, archive = {J_ANGEW}, author = {Minchao Liu and Zirui Lv and Yao Peng and Yufang Kou and Tiancong Zhao and Hongyue Yu and Jia Jia and Lifei Gao and Cheng Shang and Fan Zhang and Dongyuan Zhao and Xiaomin Li}, doi = {10.1002/anie.202423939}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423939}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking advanced architectures of single-crystal Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). A metastable state facilitates low temperature CO oxidation over pt nanoparticles. ANGEW, 64(14), e202423880. (www)

  @article{ , abstract = {The dynamic response of heterogeneous catalytic materials to their environment opens a wide variety of possible surface states which may have increased catalytic activity. In this work, we find that it is possible to generate a surface state with increased catalytic activity over metallic 2 nm Pt nanoparticles by performing a thermal treatment of the CO*-covered Pt catalyst. This state is characterised by its ability to oxidise CO to CO 2 at room temperature. By combining pressure pulse experiments with in situ spectroscopy we correlate the formation of this high-activity state with the desorption of weakly bound CO* molecules from well-coordinated Pt sites. This high-activity state is metastable, degrading after elevated thermal treatments or upon readsorption of CO at room temperature. We conclude that this metastable state is highly localised to the surface of the nanoparticle, however its exact atomic structure remains open to speculation.}, archive = {J_ANGEW}, author = {Samantha L. Le and Christopher R. O'Connor and Taek-Seung Kim and Christian Reece}, doi = {10.1002/anie.202423880}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423880}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A metastable state facilitates low temperature CO oxidation over pt nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Surface reconstruction of an integrated CoO-Co2Mo3O8 electrode enabling efficient ampere-level hydrogen evolution in alkaline water or seawater. ANGEW, 64(14), e202423863. (www)

  @article{ , abstract = {To accelerate the water dissociation in the Volmer step and alleviate the destruction of bubbles to the physical structure of catalysts during the alkaline hydrogen evolution, an integrated electrode of cobalt oxide and cobalt-molybdenum oxide grown on Ni foam, named CoO-Co 2 Mo 3 O 8 , is designed. This integrated electrode enhances the catalyst-substrate interaction confirmed by a micro-indentation tester, and thus hinders the destruction of the physical structure of catalysts caused by bubbles. Electrochemical testing shows the occurrence of a surface reconstruction of the integrated electrode, and CoO is transformed into Co(OH) 2 , denoted as Co(OH) 2 -Co 2 Mo 3 O 8 . Theoretical calculations determine that Co(OH) 2 -Co 2 Mo 3 O 8 has significantly low activation barrier for water dissociation and presents easy hydroxide desorption, which accelerate the catalytic reaction. Electrochemical experiments show that Co(OH) 2 -Co 2 Mo 3 O 8 exhibits outstanding activity, reaching current density values of −100 and −1000 mA cm −2 with overpotentials only 57.8 and 195.8 mV, respectively. Furthermore, it demonstrates excellent stability at −500 and −1000 mA cm −2 for 200 h. Combined with the previously reported anode, the two-electrode system also provides the stable operation from 100 to 1000 mA cm −2 for 600 h in alkaline solution, and over 200 h at 500 and 1000 mA cm −2 in alkaline seawater.}, archive = {J_ANGEW}, author = {Jiajia Lu and Peng-Jun Deng and Yang Liu and Shengyu Jing and Panagiotis Tsiakaras}, doi = {10.1002/anie.202423863}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423863}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface reconstruction of an integrated CoO-Co2Mo3O8 electrode enabling efficient ampere-level hydrogen evolution in alkaline water or seawater}, volume = {64}, year = {2025}, }
• (2025). Crystal-facet engineering of mesoporous CuS cascade nanoreactors enhances photocatalytic C−C coupling of CO2-to-C2H4. ANGEW, 64(14), e202423861. (www)

  @article{ , abstract = {Crystal-facet heterojunction engineering of mesoporous nanoreactors with highly redox-active represents an efficacious strategy for the transformation of CO 2 into valuable C 2 products (e.g., C 2 H 4 ). Herein, hollow mesoporous cube-like CuS nanoreactors (~860 nm) with controlled anisotropic crystal-facets are prepared through an interfacial-confined ion dynamic migration-rearrangement strategy. The regulation of the S 2− ion concentration facilitates the modulation of the highly active (110) to (100) crystal-facet ratios from 0.119 to 0.288, and induces the formation of anisotropic crystal-facet heterojunctions. The controllable crystal-facet heterojunctions trigger the directional charge carrier migration, and are accompanied with the formation of tandem S-defect sites (Cu 0 -S 1 @S 3 ). Both of them promote the efficient electron-hole pair dissociation and attain asymmetric C−C coupling. The hollow mesoporous CuS nanoreactors with optimized crystal-facet ratio of 0.224 (HMe-CuS-3) deliver a high selectivity of 72.7 % for the photocatalytic reduction of CO 2 to acetylene (C 2 H 2 ). Further constructed Au-(110) and Co 3 O 4 -(100) spatially separated cascade nanoreactors (SS-Au@Co 3 O 4 -CuS) achieve CO 2 -C 2 H 4 photoreduction, in which the Co-sites enhance H 2 O dissociation to provide protons and the protonation of *CO to *COH. The *COH is further captured by Au-sites to accomplish the asymmetric *CO-*COH coupling and subsequent protonation, ensuring a high C 2 H 4 generation rate of 4.11 μmol/g/h with a selectivity as high as 90.6 %.}, archive = {J_ANGEW}, author = {Jiaming Zhang and Linlin Duan and Wei Zhang and Bing Ma and Jiangwei Zhang and Jinying Li and Aixia Wang and Peiting Guo and Dongyuan Zhao and Yuzhu Ma}, doi = {10.1002/anie.202423861}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423861}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystal-facet engineering of mesoporous CuS cascade nanoreactors enhances photocatalytic C−C coupling of CO2-to-C2H4}, volume = {64}, year = {2025}, }
• (2025). Tunable organic-inorganic p-π-d electron conjugation triggers d-π hybridization in quinonized MnO2 superlattice toward ultrastable and high-rate Zn−MnO2 batteries. ANGEW, 64(14), e202423824. (www)

  @article{ , abstract = {Zn-MnO 2 batteries with two-electron transfer harvest high energy density, high working voltage, inherent safety, and cost-effectiveness. Zn 2+ as the dominant charge carriers suffer from sluggish kinetics due to the strong Zn 2+ −MnO 2 coulombic interaction, which is also the origin of pestilent MnO 2 lattice deformation and performance degradation. Current studies particularly involve H + insertion-dominating chemistry, where the long-term cycle stability remains challenging due to the accumulative Zn 2+ insertion and structural collapse. Herein, a simultaneously enhanced and stabilized Zn 2+ /H + co-insertion chemistry is proposed by the quinone-hybridized MnO 2 superlattice, a first-of-this-kind structure with a distinctive organic–inorganic-extended p-π-d conjugation, which enables a tunable interlayer d-π hybridization. Theoretical and experimental results substantiate that the interlayer d-π hybridization triggers the enhancement of polarons occupancy near Fermi level, the downward shift of O p-band center, the elevated Mn t 2g occupation and thus improved [MnO 6 ] stability upon unprecedentedly high Zn 2+ contribution. The notable d-π hybridization endows MnO 2 superlattice an ultrahigh specific capacity (435.9 mAh g −1 at 0.25 A g −1 ), state-of-the-art cycle stability (~100 % capacity retention after 30,000 cycles at 10 A g −1 ) with substantially enhanced rate performance. Our findings enlighten a new paradigm in the adjustment of Zn 2+ /H + co-insertion chemistry towards high-performance rechargeable aqueous batteries.}, archive = {J_ANGEW}, author = {Anqi Zhang and Tiande Chen and Ran Zhao and Yahui Wang and Jingjing Yang and Xiaomin Han and Xinran Wang and Chuan Wu and Ying Bai}, doi = {10.1002/anie.202423824}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423824}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tunable organic-inorganic p-π-d electron conjugation triggers d-π hybridization in quinonized MnO2 superlattice toward ultrastable and high-rate Zn−MnO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Porous organic polymers incorporating shape-persistent cyclobenzoin macrocycles for organic solvent separation. ANGEW, 64(14), e202423809. (www)

  @article{ , abstract = {The recovery and separation of organic solvents is highly important for the chemical industry and environmental protection. In this context, porous organic polymers (POPs) have significant potential owing to the possibility of integrating shape-persistent macrocyclic units with high guest selectivity. Here, we report the synthesis of a macrocyclic porous organic polymer ( np -POP) and the corresponding model compound by reacting the cyclotetrabenzil naphthalene octaketone macrocycle with 1,2,4,5-tetraaminobenzene and 1,2-diaminobenzene, respectively, under solvothermal conditions. Co-crystallization of the macrocycle and the model compound with various solvent molecules revealed their size-selective inclusion within the macrocycle. Building on this finding, the np -POP with a hierarchical pore structure and a surface area of 579 m 2 g −1 showed solvent uptake strongly correlated with their kinetic diameters. Solvents with kinetic diameters below 0.6 nm – such as acetonitrile and dichloromethane – showed high uptake capacities exceeding 7 mmol g −1 . Xylene separation tests revealed a high overall uptake (~34 wt %), with o -xylene displaying a significantly lower uptake (~10 wt % less than other isomers), demonstrating the possibility of size and shape selective separation of organic solvents.}, archive = {J_ANGEW}, author = {Timur Ashirov and Jay Lim and Alexandra Robles and Thamon Puangsamlee and Patrick W. Fritz and Aurelien Crochet and Xiqu Wang and Connor Hewson and Paul Iacomi and Ognjen Š. Miljanić and Ali Coskun}, doi = {10.1002/anie.202423809}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423809}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porous organic polymers incorporating shape-persistent cyclobenzoin macrocycles for organic solvent separation}, volume = {64}, year = {2025}, }
• (2025). Tiny-ligand solvation electrolyte enabled fast-charging aqueous batteries. ANGEW, 64(14), e202423808. (www)

  @article{ , abstract = {The H-bond network among H 2 O molecules enables ultrafast diffusion of H + and OH − via a hopping mechanism, making aqueous batteries attractive competitors for next-generation fast-charging energy storages. Ideal aqueous electrolyte for the widely used lithium-ion batteries is expected to have the wide electrochemical stability window (>5 volts), fast charging (≤15 minutes) without gas evolution, and low cost. However, the hydrogen evolution reaction (HER) associated with narrow voltage window of water (1.23 V) limits their practical applications. Herein, we built a new guideline for designing tiny-ligand electrolytes by utilizing sterically hindered groups with low binding energy. Cosolvent tetraethyl orthocarbonate (TEOC), with large-sized ethoxy groups and hydrogen-bond-captured ability, forces free H 2 O and anion TFSI − into the Li + first solvation shell. Hence, inhibition of HER takes place by means of immobilized H 2 O activity and formation of hydrogen-bonding networks —C−O⋅⋅⋅H between TEOC and H 2 O. This unique structure with ultra-small sheath volume thereby facilitates the formation of LiF-rich SEI and fast ion-conduction. The lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) in TEOC/H 2 O electrolyte exhibits wide electrochemical window of 5.7 V, enabling LiMn 2 O 4 /Li 4 Ti 5 O 12 pouch cells to achieve 1200 cycles under rapid 10 C rate. This engineering of tiny-ligand solvation opens new pathways for developing advanced electrolyte that balance performance with sustainability.}, archive = {J_ANGEW}, author = {Yanxin Shang and Nan Chen and Yuejiao Li and Shi Chen and Zhujie Li and Shengxi Li and Xuening Ren and Yusheng Ye and Li Li and Feng Wu and Renjie Chen}, doi = {10.1002/anie.202423808}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423808}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tiny-ligand solvation electrolyte enabled fast-charging aqueous batteries}, volume = {64}, year = {2025}, }
• (2025). Stereochemistry-tuned hydrogen-bonding synergistic covalent adaptable networks: Towards recycled elastomers with excellent creep-resistant performance. ANGEW, 64(14), e202423712. (www)

  @article{ , abstract = {Covalent adaptable networks (CANs) offer innovative solutions for the reprocessing and recycling of thermoset polymers. However, achieving a balance between easy reprocessing and creep resistance remains a challenge. This study focuses on designing and synthesizing polyurethane (PU) materials with tailored properties by manipulating the stereochemistry of diamine chain extenders. By employing cis- and trans- configurations of diamine extenders, we developed a series of PU materials with varying mechanical properties and creep resistance. The trans -configured materials ( R , R -DAC-PU or S , S -DAC-PU) exhibited superior creep resistance and mechanical strength due to dense hydrogen bonding networks. The cis -configured materials ( Cis -DAC-PU) exhibited enhanced processability and elasticity. Under 0.1 MPa stress, R , R -DAC-PU showed a mere 3.5 % strain change at 170 °C over 60 minutes, highlighting its superior creep resistance. Both configurations can be recycled via urea bond exchange reactions using hot pressing or solvothermal methods. Density Functional Theory (DFT) calculations indicate that both the ( R , R -DCA-UB-U) 2 and ( S , S -DCA-UB-U) 2 segments form six hydrogen bonds with shorter bond lengths, leading to stronger hydrogen-bonding interactions. Conversely, the ( Cis -DCA-UB-U) 2 segment forms four hydrogen bonds with longer bond lengths, resulting in weaker interactions. This work highlights the critical role of stereochemistry in designing high-performance, recyclable polymer materials with tailored properties.}, archive = {J_ANGEW}, author = {Zhenghuai Feng and Miao Xie and Jialiang Lai and Zhanhua Wang and Hesheng Xia}, doi = {10.1002/anie.202423712}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423712}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereochemistry-tuned hydrogen-bonding synergistic covalent adaptable networks: Towards recycled elastomers with excellent creep-resistant performance}, volume = {64}, year = {2025}, }
• (2025). Comprehensive passivation of surface and bulk defects in perovskite for high efficiency carbon-based CsPbI3 solar cells. ANGEW, 64(14), e202423655. (www)

  @article{ , abstract = {Carbon-based perovskite solar cells (C-PSCs) have the advantages of high stability and low cost, but their mean efficiency has become an obstacle to commercialization. Defects, which are widely distributed on the surface and bulk of films, are an important factor in C-PSCs for low efficiency. The conventional post-treatment method through forming a low-dimensional (LD) perovskite layer usually fails in manipulating the bulk defects. Herein, we propose a strategy of combining wet film (uncrystallized) treatment with dry film treatment to in situ form LD perovskite throughout the grain boundaries inside of the film and on the surface of the film, thereby simultaneously passivating the bulk and surface defects in the CsPbI 3 film. As a result, the photoluminescence lifetime is significantly improved from 22.5 ns to 92.1 ns. The assembled CsPbI 3 C-PSCs based on the above strategy deliver a champion efficiency of 19.65 %, which is a new record efficiency for inorganic C-PSCs.}, archive = {J_ANGEW}, author = {Jianxin Zhang and Xin Peng and Haosheng Wu and Guizhi Zhang and Yueying Chen and Weizi Cai and Zhenxiao Pan and Huashang Rao and Xinhua Zhong}, doi = {10.1002/anie.202423655}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423655}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Comprehensive passivation of surface and bulk defects in perovskite for high efficiency carbon-based CsPbI3 solar cells}, volume = {64}, year = {2025}, }
• (2025). Exploiting lattice carbon-induced modulation effect in nickel towards efficient alkaline hydrogen oxidation. ANGEW, 64(14), e202423647. (www)

  @article{ , abstract = {Doping with non-metallic heteroatom is an effective approach to tailor the electronic structure of Ni for enhancing its alkaline hydrogen oxidation reaction (HOR) catalytic performance. However, the modulation of HOR activity of Ni by lattice carbon (LC) atoms has rarely been reported, especially to reveal the rule between the doping effect and activity caused by the content of LC atoms. Here, hydrogen is proposed as a scavenger for LC atoms in the pyrolytic reduction process to finely control the content of LC atoms in Ni. With the removal of LC atoms in Ni lattice, the electronic structure changes from Ni 3 C-like electronic structure to quasi-Ni structure. Furthermore, a volcanic relationship between the LC content and HOR activity of Ni is established for the first time. The C less -Ni (LC 0.44 -Ni) with optimized LC content shows the best activity owing to the weakened hydrogen binding energy (HBE) and optimal hydroxyl binding energy (OHBE). This work provides an inspiration for the design of high-performance catalysts by tailoring the electronic structure of the metal via LC atoms doping.}, archive = {J_ANGEW}, author = {Jian He and Liu Luo and Jinchi Li and Shiqi Chen and Shuqi Yu and Liang Zeng and Yao Wang and Yungui Chen}, doi = {10.1002/anie.202423647}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423647}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploiting lattice carbon-induced modulation effect in nickel towards efficient alkaline hydrogen oxidation}, volume = {64}, year = {2025}, }
• (2025). Ultrafast water purification by template-free nanoconfined catalysts derived from municipal sludge. ANGEW, 64(14), e202423629. (www)

  @article{ , abstract = {Nanoconfinement at the interface of heterogeneous Fenton-like catalysts offers promising avenues for advancing oxidation processes in water purification. Herein, we introduce a template-free strategy for synthesizing nanoconfined catalysts from municipal sludge (S-NCCs), specifically engineered to optimize reactive oxygen species (ROS) generation and utilization for rapid pollutant degradation. Using selective hydrofluoric acid corrosion, we create an architecture that confines atomically dispersed Fe centers within a micro-mesoporous carbon matrix in situ. This method maximizes the utilization of silicon and aluminum content from sludge, prevents metal agglomeration, and precisely regulates the chemical environment of Fe active sites. As a result, the S-NCCs promote a transition from nonradical to hybrid radical/nonradical reaction mechanisms, significantly enhancing ROS efficiency, stability, and pollutant degradation rates. These catalysts demonstrate exceptional pollutant removal performance, achieving a 261-fold increase in degradation efficiency for compounds such as phenol and sulfamethoxazole compared to unconfined analogs, outperforming most state-of-the-art Fenton-like systems. Our findings highlight the transformative potential of nanoconfined catalysis in environmental applications, providing an effective and scalable solution for sustainable water purification.}, archive = {J_ANGEW}, author = {Chao-Hai Gu and Meng Du and Ru-Yi Han and Ai-Yong Zhang and Han-Qing Yu and Mingyang Xing}, doi = {10.1002/anie.202423629}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423629}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrafast water purification by template-free nanoconfined catalysts derived from municipal sludge}, volume = {64}, year = {2025}, }
• (2025). Quantifying asymmetric coordination to correlate with oxygen reduction activity in fe-based single-atom catalysts. ANGEW, 64(14), e202423556. (www)

  @article{ , abstract = {Precisely manipulating asymmetric coordination configurations and examining electronic effects enable to tunethe intrinsic oxygen reduction reaction (ORR) activity of single-atom catalysts (SACs). However, the lackof a definite relationship between coordination asymmetry and catalytic activity makes the rational design of SACs ambiguous. Here, we propose a concept of “asymmetry degree” to quantify asymmetric coordination configurations and assess the effectiveness of active moieties in Fe-based SACs. A theoretical framework is established, elucidating the volcanic relationship between asymmetry degree and ORR activity by constructing a series of Fe-based SAC models doped with non-metal atoms (B, P, S, Se, and Te) in the first or second coordination sphere, which aligns with Sabatier principle. The predicted ORR activity of Fe asymmetric active moieties is then experimentally validated using asymmetry degree. The combined computational and experimental results suggest that single-atom moiety with a moderate asymmetry degree exhibits optimal intrinsic ORR activity, because breaking the square-planar symmetry of FeN 4 can alter the electronic population of the Fe 3d-orbital, thereby optimizing the adsorption-desorption strength of intermediates and thus enhancing the intrinsic ORR activity. This fundamental understanding of catalytic activity from geometric and electronic aspects offers a rational guidance to design high-performance SACs with asymmetric configurations.}, archive = {J_ANGEW}, author = {Yanhui Cao and Yuan Liu and Xuerong Zheng and Jingxia Yang and Haozhi Wang and Jinfeng Zhang and Xiaopeng Han and Yida Deng and Günther Rupprechter and Wenbin Hu}, doi = {10.1002/anie.202423556}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423556}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantifying asymmetric coordination to correlate with oxygen reduction activity in fe-based single-atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Tailored polymer-inorganic bilayer SEI with proton holder feature for aqueous zn metal batteries. ANGEW, 64(14), e202423531. (www)

  @article{ , abstract = {Conventional solid-electrolyte interface (SEI) in aqueous Zn-ion batteries mainly acts as a physical barrier to prevent hydrogen evolution reaction (HER), while such SEI is prone to structural deterioration stemming from uneven Zn deposition at high current densities. Herein, we propose an in situ structural design of polymer-inorganic bilayer SEI with a proton holder feature by aniline-modulated electrolytes. The Zn(OTF) 2 exhibits a lower LUMO energy level in comparison to aniline, resulting in the formation of a bilayer structure characterized by an inner ZnF 2 layer and an outer polyaniline (PANI) layer. The ZnF 2 with high stiffness and strength effectively suppresses Zn dendrites. Meanwhile, the PANI regulates the current distribution, minimizing the concentration gradient, and delays the Sand's time of dendrites growth. Furthermore, the =N− in PANI is capable of reversible proton holder, thereby inhibiting HER. With this bilayer SEI, the Zn anode achieves an impressive cycle life of 126 h under 40 mA cm −2 & 40 mAh cm −2 (depth of discharge, DOD=70.8 %), solving the bottleneck of single-layer inorganic SEI that could not be cycled under these conditions. The Zn || NaVO pouch battery with bilayer SEI exhibits a high capacity of 1.2 Ah and a cycle life of 350 h with 78 % capacity retention. At −30 °C, the same battery delivers a capacity of 335 mAh and a cycle life of 507 h with 72 % capacity retention, attributed to the modulation mechanism of the hydrogen bonding in the electrolyte. Our findings offer profound insights into the design of SEI with tailored structure and functionality, paving the way for the next generation of advanced high-performance batteries.}, archive = {J_ANGEW}, author = {Mangwei Cui and Lidong Yu and Jin Hu and Sisi He and Chunyi Zhi and Yan Huang}, doi = {10.1002/anie.202423531}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423531}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailored polymer-inorganic bilayer SEI with proton holder feature for aqueous zn metal batteries}, volume = {64}, year = {2025}, }
• (2025). Aminopeptidase N-activated self-immolative hydrogen sulfide donor for inflammatory response-specific wound healing. ANGEW, 64(14), e202423527. (www)

  @article{ , abstract = {Hydrogen sulfide (H 2 S) plays crucial inflammatory modulating roles, representing a promising candidate for anti-inflammatory therapies. However, current H 2 S delivery approaches lack sufficient specificity against inflammatory response. Herein, regarding the overexpressed aminopeptidase N (APN) at the inflammation sites, an APN-activated self-immolative carbonyl sulfide (COS)/H 2 S donor ( AlaCOS ) was developed for inflammatory response-specific H 2 S delivery. The compound showed sustained H 2 S generation upon APN activation in the presence of carbonic anhydrase (CA), and the responsiveness could be well regulated by modulating the amino acid sequence. Due to the inflammatory response-specific sustained H 2 S delivery, AlaCOS provided potent anti-inflammatory capability, which was further validated by RNA sequencing. In vivo experiments on a full-thickness cutaneous wound murine model also showed the strong promoting effect on wound healing, mainly due to the regulation of the inflammatory response by AlaCOS . By introducing a caged coumarin fluorophore to the molecular architecture, self-reporting fluorescence could be generated accompanied with APN-mediated COS/H 2 S release, which achieved the visualization of H 2 S delivery in vitro and in vivo. This work not only offers a useful tool for studying the bioactivity of H 2 S on inflammation, but also provides new insights for developing novel therapies to cope with inflammation-associated diseases.}, archive = {J_ANGEW}, author = {Fan Rong and Wenxin Bao and Guanyi Li and Yuxuan Ge and Wangyang Zhu and Bin Hao and Yaxue Zhao and Yunsheng Yuan and Yin Wang}, doi = {10.1002/anie.202423527}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423527}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aminopeptidase N-activated self-immolative hydrogen sulfide donor for inflammatory response-specific wound healing}, volume = {64}, year = {2025}, }
• (2025). A needle in a haystack: Transient porosity in a closed pore square lattice coordination network. ANGEW, 64(14), e202423521. (www)

  @article{ , abstract = {Guest transport through discrete voids (closed pores) in crystalline solids is poorly understood. Herein, we report the gas sorption properties of a nonporous coordination network, {[Co(bib) 2 Cl 2 ] ⋅ 2MeOH} n ( sql-bib-Co-Cl-α ), featuring square lattice ( sql ) topology and the bent linker 1,3-bis(1 H -imidazol-1-yl)benzene (bib). The as-synthesized sql-bib-Co-Cl-α has 11.3 % (313 Å 3 ) of its unit cell volume in closed pores occupied by methanol (MeOH). Upon desolvation and air exposure, sql-bib-Co-Cl-α underwent a single-crystal to single-crystal (SC-SC) phase transformation to sql-bib-Co-Cl-β′ , wherein MeOH was replaced by water. Activation (vacuum or N 2 flow) resulted in dehydration and retention of the closed pores, affording sql-bib-Co-Cl-β with 7.7 % (194 Å 3 ) guest-accessible space. sql-bib-Co-Cl-β was found to preferentially adsorb C 2 H 2 (at 265 K) over CO 2 (at 195 K) through gate-opening mechanisms, at gate-opening pressures of 59.8 and 27.7 kPa, respectively, while other C2 gases were excluded. PXRD was used to monitor transformations between the three phases of sql-bib-Co-Cl , while in situ DSC, in situ SCXRD under CO 2 pressure, and computational studies provided insight into the guest transport mechanism, which we attribute to the angular, flexible nature of the bib ligand. Further, the preferential adsorption of C 2 H 2 over CO 2 and other C2 gases suggests that transiently porous sorbents might have utility in separations.}, archive = {J_ANGEW}, author = {Kyriaki Koupepidou and Alan C. Eaby and Debobroto Sensharma and Sousa Javan Nikkhah and Tao He and Matteo Lusi and Matthias Vandichel and Leonard J. Barbour and Soumya Mukherjee and Michael J. Zaworotko}, doi = {10.1002/anie.202423521}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423521}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A needle in a haystack: Transient porosity in a closed pore square lattice coordination network}, volume = {64}, year = {2025}, }
• (2025). One-step ethylene purification from ternary mixture through adaptive recognition sites. ANGEW, 64(14), e202423496. (www)

  @article{ , abstract = {One-step adsorptive purification of ethylene (C 2 H 4 ) from ternary mixture comprising of acetylene (C 2 H 2 ), ethylene (C 2 H 4 ) and carbon dioxide (CO 2 ) is a great challenge in the chemical industry. Herein, a microporous metal–organic framework ( FJI-H38) has been reported, which possesses high-density electronegative O/N binding sites and appropriate pore size. Notably, at 0.01 bar and 298 K FJI-H38 shows excellent trapping capability for C 2 H 2 (1.64 mmol/g) and CO 2 (2.33 mmol/g), while the uptake of C 2 H 4 is only 0.41 mmol/g, which endows FJI-H38 high C 2 H 2 /C 2 H 4 and top-level CO 2 /C 2 H 4 selectivity simultaneously. Polymer-grade C 2 H 4 (≥99.95 %) with record-high productivity can be successfully obtained from ternary C 2 H 2 /CO 2 /C 2 H 4 mixture in one step under various conditions. Even at 318 K, the separation performance has no obvious decrease. Such excellent separation performance is due to the adaptive recognition of C 2 H 2 and CO 2 by FJI-H38 through the synergistic effect of appropriate pore size and the match of electrostatic potentials, where C 2 H 2 and CO 2 can be stabilized by the O/N and aromatic ring sites.}, archive = {J_ANGEW}, author = {Danhua Song and Shuixiang Zou and Zhenyu Ji and Yashuang Li and Hengbo Li and Yunzhe Zhou and Cheng Chen and Qihui Chen and Mingyan Wu}, doi = {10.1002/anie.202423496}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-step ethylene purification from ternary mixture through adaptive recognition sites}, volume = {64}, year = {2025}, }
• (2025). Total syntheses of bryostatins 1, 7, 9 and 9-n3. ANGEW, 64(14), e202423465. (www)

  @article{ , abstract = {Bryostatins are a family of marine natural products that have garnered significant interests, as evidenced by over 40 clinical trials. However, their extremely low natural abundance has severely limited further research. Despite significant efforts, which have led to the total synthesis of seven bryostatin members by eight independent research groups, these complex molecules present persistent challenges for stereocontrolled, large-scale, and especially divergent synthesis. Here, we report the divergent total syntheses of bryostatins 1, 7, 9 and 9-N 3 . Notably, 1.5 g of bryostatin 1 was obtained in a single sequence of the final three steps. Key transformations include Ni-catalyzed reductive cross-coupling to rapidly assemble the northern fragment, the flow chemistry-assisted visible light-induced alkyl radical conjugate addition to convergently construct the southern fragment, and an intramolecular geminal bis(silyl) Prins cyclization to establish the cis-Z selectivity on the B-ring. The syntheses consist of 20–22 steps in the longest linear sequence and 33–35 total steps, with overall yields ranging from 3.3 % to 4.5 %.}, archive = {J_ANGEW}, author = {Qianyou Guo and Yufan Yang and Hongyun Zhang and Dongxu Wang and Bing Li and Dongyang Jiang and Xiaoyu Tu and Xin Gao and Chao Zhang and Yong Qin and Lu Gao and Wanshu Wang and Zhenlei Song}, doi = {10.1002/anie.202423465}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423465}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total syntheses of bryostatins 1, 7, 9 and 9-n3}, volume = {64}, year = {2025}, }
• (2025). Harnessing adsorbate-adsorbate interaction to activate C−N bond for exceptional photoelectrochemical urea oxidation. ANGEW, 64(14), e202423457. (www)

  @article{ , abstract = {The photoelectrochemical (PEC) urea oxidation reaction (UOR) presents a promising half-reaction for green hydrogen production, but the stable resonance structure of the urea molecule results in sluggish kinetics for breaking the C−N bond. Herein, we realize the record PEC UOR performance on a NiO-modified n-Si photoanode (NiO@Ni/n-Si) by harnessing the adsorbate-adsorbate interaction. We quantificationally unveil a dependence of the UOR activation barrier on the coverage of photogenerated surface high-valent Ni-oxo species (Ni IV =O) by employing operando PEC spectroscopic measurements and theoretical simulations. The strong attraction between Ni IV =O and adsorbed urea facilitates their N−O coupling while weakening the C−N bonding within urea, manifesting as the decreased UOR activation energy from 0.74 to 0.41 eV when the surface coverage of Ni IV =O is enhanced from zero to full, corresponding to more than two orders of magnitude enhancement for the UOR rate. Furthermore, an industrial-grade photocurrent density of 100 mA cm −2 is achieved at a potential as low as 1.08 V RHE by stimulating the Ni IV =O accumulation under 10 Suns, which is 300 mV lower than the potential required for most reported electrochemical counterparts. This work opens new prospects for achieving high-performance PEC urea oxidation via adsorbate-adsorbate interaction.}, archive = {J_ANGEW}, author = {Kun Dang and Lei Wu and Siqin Liu and Shenlong Zhao and Yuchao Zhang and Jincai Zhao}, doi = {10.1002/anie.202423457}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423457}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing adsorbate-adsorbate interaction to activate C−N bond for exceptional photoelectrochemical urea oxidation}, volume = {64}, year = {2025}, }
• (2025). Electrocatalytic acetylene semi-hydrogenation to ethylene with high energy efficiency. ANGEW, 64(14), e202423381. (www)

  @article{ , abstract = {Electrocatalytic acetylene semi-hydrogenation (EASH) provides a petroleum-independent strategy for ethylene production. However, the challenges of high overpotentials and strong hydrogen evolution competition reaction over conventional electrocatalysts at industrial current densities result in substantial energy consumption, limiting the practical application of EASH technology. Herein, zinc-doped copper catalysts are designed and prepared via a facile impregnation and electroreduction relay method. The as-prepared Cu-2.7Zn catalyst exhibits an ethylene partial current density of −0.29 A cm −2 with a Faradaic efficiency of 96 % and a reaction potential of −0.62 V versus reversible hydrogen electrode (RHE), surpassing the previously reported electrocatalysts. The combined results of experimental tests and theoretical calculations demonstrate zinc doping significantly enhances acetylene adsorption and accelerates reaction kinetics, leading to a notable decrease in overpotential. Furthermore, the increased *H-*H binding energy barrier and the improved ethylene desorption on Cu-2.7Zn effectively suppress hydrogen evolution and acetylene over-hydrogenation, contributing to the enhancement of ethylene Faradaic efficiency.}, archive = {J_ANGEW}, author = {Cong Dou and Yanmei Huang and Bohang Zhao and Weiwei Lei and Bin Zhang and Yifu Yu}, doi = {10.1002/anie.202423381}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423381}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrocatalytic acetylene semi-hydrogenation to ethylene with high energy efficiency}, volume = {64}, year = {2025}, }
• (2025). Revealing the CO tolerance mechanism in acidic hydrogen oxidation reactions on platinum-based catalyst surfaces. ANGEW, 64(14), e202423301. (www)

  @article{ , abstract = {The presence of trace CO impurity gas in hydrogen fuel can rapidly deactivate platinum-based hydrogen oxidation reaction (HOR) catalysts due to poisoning effects, yet the precise CO tolerance mechanism remains debated. Our designed Au@PtX bifunctional core–shell nanocatalysts exhibit excellent performance of CO tolerance in acidic solution during HOR and possess exceptional Raman spectroscopy enhancement. Through capturing and analyzing in situ Raman spectroscopy evidences on *OH, metal-O species and *CO evolution under 0.3 V, we confirm that oxygen-containing species on PtRu and PtSn catalysts promote the oxidation and desorption of *CO. While Ru enhances *CO adsorption on Pt, the primary CO tolerance performance of PtRu arises from *CO oxidation via a bifunctional pathway. Additionally, electronic structure of Sn reduces *CO adsorption on Pt sites, complementing the bifunctional mechanism to further enhance the CO tolerance performance of PtSn. These discoveries significantly deepen our understanding of the anti-poisoning mechanism of Pt-based catalysts in the HOR process and offer valuable insights for rational catalyst design.}, archive = {J_ANGEW}, author = {Zi-Han Chen and Xing Chen and Wei Kang and Shisheng Zheng and Quan-Feng He and Qiong-Qiong Li and Yu-Xing Zhang and Yu-Cheng Hou and Jing-Hua Tian and Jin-Chao Dong and Jian-Feng Li}, doi = {10.1002/anie.202423301}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423301}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing the CO tolerance mechanism in acidic hydrogen oxidation reactions on platinum-based catalyst surfaces}, volume = {64}, year = {2025}, }
• (2025). Strategic nitrogen site alignment in covalent organic frameworks for enhanced performance in aqueous zinc-iodide batteries. ANGEW, 64(14), e202423265. (www)

  @article{ , abstract = {Aqueous zinc-iodine batteries (AZIBs) are gaining attention as next-generation energy storage systems due to their high theoretical capacity, enhanced safety, and cost-effectiveness. However, their practical application is hindered by challenges such as slow reaction kinetics and the persistent polyiodide shuttle effect. To address these limitations, we developed a novel class of covalent organic frameworks (COFs) featuring electron-rich nitrogen sites with varied density and distribution (N 1 -N 4 ) along the pore walls. These nitrogen sites enhance iodine species confinement and mass transport. Our experimental and theoretical studies reveal that the continuous and optimized distribution of nitrogen sites within the COF structure significantly reduces internal resistance and boosts redox activity. Moreover, the N 4 -COF demonstrates superior performance compared to other porous materials, due to its high density and strategic alignment of active sites. The I 2 @N 4 -COF cathode achieves a remarkable specific capacity of 348 mAh g −1 at 1 C, almost 1.8 times greater than that of the I 2 @N 1 -COF, while also maintaining excellent cycling stability. This integration of a porous framework with aligned nitrogen sites in the N 4 -COF structure not only enhances iodine redox behavior but also offers a promising design strategy for developing high-performance AZIB electrodes.}, archive = {J_ANGEW}, author = {Liying Yin and Xiaoyu Guo and Junfang Hu and Kaimeng Yan and Lin Liu and Xiaoyuan Shi and Fengchao Cui and Guangshan Zhu and Ning Zhang}, doi = {10.1002/anie.202423265}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423265}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strategic nitrogen site alignment in covalent organic frameworks for enhanced performance in aqueous zinc-iodide batteries}, volume = {64}, year = {2025}, }
• (2025). From autonomous chemical micro-/Nanomotors to rationally engineered bio-interfaces. ANGEW, 64(14), e202423207. (www)

  @article{ , abstract = {Developing micro-/nanomotors that convert a chemical energy input into a local gradient field and motion is an appealing but challenging task that holds particular promise for the intersection of materials and nanoengineering. Over the past two decades, remarkable advancements have refined these out-of-equilibrium chemically powered micro-/nanomotors, enabling them to orchestrate in situ chemical transformations that dynamically change local environments. The ionic products, radicals, gases, and electric fields from these active materials reshape the microenvironment, paving the way for ecofriendly disease interventions. This review discusses the state-of-the-art reactions that propel these energy-consuming micro-/nanomotors and elucidates the emerging implications of their products on biological systems. Particular emphasis has been placed on their potential for neural modulation, reactive oxygen species (ROS) regulation, synergistic tumor therapy, antibacterial strategies, and tissue regeneration. Collectively, these sketches provide a landscape of therapeutic modalities, heralding a new era of biomedicine. By harnessing the in situ product field of this active matter, we envision a paradigm shift toward active therapies that transcend conventional approaches, promising breakthroughs in disease diagnosis, treatment, and prevention.}, archive = {J_ANGEW}, author = {Miaomiao Ding and Bin Chen and Daniela A. Wilson and Yingfeng Tu and Fei Peng}, doi = {10.1002/anie.202423207}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423207}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From autonomous chemical micro-/Nanomotors to rationally engineered bio-interfaces}, volume = {64}, year = {2025}, }
• (2025). Optimized directed evolution of e. coli leucyl-tRNA synthetase adds many noncanonical amino acids into the eukaryotic genetic code including ornithine and nϵ-acetyl-methyllysine. ANGEW, 64(14), e202423172. (www)

  @article{ , abstract = {Site-specific incorporation of noncanonical amino acids (ncAAs) into proteins in eukaryotes has predominantly relied on the pyrrolysyl-tRNA synthetase/tRNA pair. However, access to additional easily engineered pairs is crucial for expanding the structural diversity of the ncAA toolbox in eukaryotes. The Escherichia coli -derived leucyl-tRNA synthetase (EcLeuRS)/tRNA pair presents a particularly promising alternative. This pair has been engineered to charge a small yet structurally diverse group of ncAAs in eukaryotic cells. However, expanding the substrate scope of EcLeuRS has been difficult due to the suboptimal yeast-based directed evolution platform used for its engineering. In this study, we address this limitation by optimizing the yeast-based directed evolution platform for efficient selection of ncAA-selective EcLeuRS mutants. Using the optimized selection system, we demonstrate rapid isolation of many novel EcLeuRS mutants capable of incorporating various ncAAs in mammalian cells, including ornithine and N ϵ -acetyl-methyllysine, a recently discovered post-translational modification in mammalian cells.}, archive = {J_ANGEW}, author = {Elise D. Ficaretta and Tarah J. Yared and Subrata Bhattacharjee and Lena A. Voss and Rachel L. Huang and Abhishek Chatterjee}, doi = {10.1002/anie.202423172}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423172}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimized directed evolution of e. coli leucyl-tRNA synthetase adds many noncanonical amino acids into the eukaryotic genetic code including ornithine and nϵ-acetyl-methyllysine}, volume = {64}, year = {2025}, }
• (2025). Manipulating charge distribution at organic-inorganic interface via optimizing substituents for sustainable water electrolysis. ANGEW, 64(14), e202423145. (www)

  @article{ , abstract = {The space charge effect induced by high-quality heterojunctions is essential for efficient electrocatalytic processes. Herein, we delicately manipulate intermolecular charge transfer by modifying substituents (−g=-CH 3 , -H, -NO 2 ) with various electron donating/withdrawing capabilities in CoPc-g/CoS organic–inorganic heterostructures. CoPc-CH 3 , as a typical electron donor, transfers more electrons to CoS due to the presence of -CH 3 , forming the strongest space electric field and thus regulating the dual active sites at the interface. Furthermore, oxygen-containing intermediates preferentially adsorb on the positively charged CoPc-CH 3 side, and the rapid accumulation of electrons on the CoS side decelerates catalyst dissolution at the oxygen evolution reaction (OER) potential, ensuring the stable OER process under the optimized adsorbate evolution mechanism. As a result, CoPc-CH 3 /CoS catalyst exhibits the lowest overpotential and remains stable for 150 h at 0.5 A cm −2 in the membrane electrode assembly electrolyzer. The method provides a novel strategy for accurately regulating the space electric field of heterojunctions.}, archive = {J_ANGEW}, author = {Ling Jiang and Yixin Hao and Mingzheng Gu and Liming Deng and Qiao Chen and Xiaojun Zhang and Linlin Li and Shengjie Peng and Guangfeng Wang}, doi = {10.1002/anie.202423145}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423145}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating charge distribution at organic-inorganic interface via optimizing substituents for sustainable water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Upcycling polynorbornene derivatives into chemically recyclable multiblock linear and thermoset plastics. ANGEW, 64(14), e202423111. (www)

  @article{ , abstract = {Synthetic polymers have found widespread use, but their ineffective end-of-life treatment is causing a significant environmental and human health crisis. Here, we demonstrate the upcycling of polynorbornene derivatives (pNBEs) through their deconstruction into distinct oligomeric buildings blocks that can be repolymerized into chemically recyclable pNBEs-like multiblock polymers via dehydrogenative polymerization. The resulting materials exhibit diverse mechanical properties, while integrating high melting temperatures ( T m as high as 133 °C). Notably, this method could also enable the selective deconstruction of permanently cross-linked polydicyclopentadiene (pDCPD) thermosets into telechelic-OH functionalized oligomers, overcoming the significant challenges posed by their robust network structure in recycling and degradation. The resulting pDCPD oligomers can subsequently be repolymerized with macrodiols to create multiblock thermosets with tunable mechanical properties, including Young's modulus and tensile elongation. After use, upcycled plastics could be effectively deconstructed back to the oligomers for recovery and repolymerization. Overall, this work establishes an approach that can be utilized to upcycle pNBEs into previously inaccessible multiblock thermosets and thermoplastics with full recyclability, and may be generalizable to a range of polymers to shift their end-of-life waste disposal toward sustainable recovery and reuse.}, archive = {J_ANGEW}, author = {Kun Liu and Megan E. Battson and Zhitao Hu and Yucheng Zhao and Emma M. Rettner and Joel Miscall and Nicholas A. Rorrer and Garret M. Miyake}, doi = {10.1002/anie.202423111}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423111}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Upcycling polynorbornene derivatives into chemically recyclable multiblock linear and thermoset plastics}, volume = {64}, year = {2025}, }
• (2025). Dissociation–Precipitation chemistry of lithium polysulfides and its correlation to dynamic evolution of Cathode–Electrolyte interphase in highly solvating electrolyte. ANGEW, 64(14), e202423046. (www)

  @article{ , abstract = {Lithium–sulfur (Li−S) batteries has been regarded as one of the most promising next-generation energy storage systems due to their high theoretical energy density. However, the practical application of Li−S batteries is still hindered by the unstable cathode-electrolyte interphase and the early passivation of charge product (Li 2 S), leading to poor cycling stability and low S utilization. Herein, we propose an electrolyte engineering strategy using highly solvating hexamethylphosphoramide (HMPA) as a co-solvent to elucidate the dissociation–precipitation chemistry of lithium polysulfides (LiPSs). The multimode optical spectroscopies confirm that this electrolyte engineering is able to effectively regulate the solvation of LiPSs to initiate a radical-assisted conversion pathway and control three-dimensional (3D) Li 2 S electrodeposition to boost sulfur utilization. More importantly, the dynamic evolution of cathode–electrolyte interphase, featuring with S-/P-containing species, is also assessed by both distribution of relaxation times technology and X-ray photoelectron spectroscopy, which can suppress the passivation of Li 2 S to enhance conversion reversibility. As a proof-of-concept, a Li−S cell with high S loading mass of 7.75 mg cm −2 demonstrates an extremely high area capacity of 7.86 mAh cm −2 at a current density of 1.30 mA cm −2 , representing a significant advancement in promoting the development of practical high-energy-density Li−S batteries.}, archive = {J_ANGEW}, author = {Luyi Chen and Jiawei Lai and Xiaoxian Guan and Hanqin Zou and Jingwen Liu and Lin Peng and Jian Wang and Yue-Peng Cai and Qifeng Zheng}, doi = {10.1002/anie.202423046}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423046}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dissociation–Precipitation chemistry of lithium polysulfides and its correlation to dynamic evolution of Cathode–Electrolyte interphase in highly solvating electrolyte}, volume = {64}, year = {2025}, }
• (2025). Breaking anionic solvation barrier for safe and durable potassium-ion batteries under ultrahigh-voltage operation. ANGEW, 64(14), e202423044. (www)

  @article{ , abstract = {Ultrahigh-voltage potassium-ion batteries (PIBs) with cost competitiveness represent a viable route towards high energy battery systems. Nevertheless, rapid capacity decay with poor Coulombic efficiencies remains intractable, mainly attributed to interfacial instability from aggressive potassium metal anodes and cathodes. Additionally, high reactivity of K metal and flammable electrolytes pose severe safety hazards. Herein, a weakly solvating fluorinated electrolyte with intrinsically nonflammable feature is successfully developed to enable an ultrahigh-voltage (up to 5.5 V) operation. Through breaking the anionic solvation barrier, synergistic interfacial modulation can be achieved by the formation of robust anion-derived inorganic-rich electrode-electrolyte interfaces on both the cathode and anode. As proof of concept, a representative KVPO 4 F cathode can sustain 1600 cycles with 84.4 % of capacity retention at a high cutoff voltage of 4.95 V. Meanwhile, K plating/stripping process in our designed electrolyte also demonstrates optimized electrochemical reversibility and stability with effectively inhibited potassium dendrites. These findings underscore the critical impact of anion-dominated solvation configuration on synergistic interfacial modulation and electrochemical properties. This work provides new insights into rational design of ultrahigh-voltage and safe electrolyte for advanced PIBs.}, archive = {J_ANGEW}, author = {Yong-Li Heng and Zhen-Yi Gu and Han-Hao Liu and Hao-Jie Liang and Yating Deng and Jian Zhao and Xiao-Tong Wang and Zi-Hang Xue and Hong-Yan Lü and Xing-Long Wu}, doi = {10.1002/anie.202423044}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423044}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking anionic solvation barrier for safe and durable potassium-ion batteries under ultrahigh-voltage operation}, volume = {64}, year = {2025}, }
• (2025). The role of open-shell organic radical in enhancing anti-tumor photocatalysis reaction of NIR light-activated photosensitizer. ANGEW, 64(14), e202423023. (www)

  @article{ , abstract = {Open-shell radical materials, which are characterized by unpaired electrons, have led to revolutionary breakthroughs in material science due to their unique optoelectronic properties. However, the involvement of organic radicals in photodynamic therapy (PDT) has rarely been reported or discussed. This work studies two photosensitizer analogs. 4AM-OS with extended π-conjugation exhibits open-shell radical characters and enhanced type-I photodynamic activity compared with closed-shell 2AM-CS. 4AM-OS displays the thermally accessible triplet-state character, resulting in more unpaired electrons delocalized along the π-conjugated backbone at higher temperatures. Accordingly, the temperature-dependent photodynamic activity of 4AM-OS confirms its association with the open-shell electronic structure. As the unpaired electrons in open-shell 4AM-OS are more delocalized and generate additional electronic energy states, photo-induced charge transfer is promoted to facilitate type-I photodynamic reactions. This observation addresses the challenge associated with near-infrared (NIR) photosensitizers, such as 4AM-OS, which often demonstrate low efficacy in PDT due to the limited energy provided by NIR light despite its superior tissue penetration depth. Overall, clarifying the beneficial role of organic radicals in photodynamic reactions will bring revolutionary breakthroughs to developing high-performance NIR photosensitizers and promoting the efficacy of PDT for deep-seated lesions.}, archive = {J_ANGEW}, author = {Heng Li and Ying Gu and Yafei Ding and Jia Huang and Zhiqiang Yang and Pengbo Ding and Mengying Wang and Liang Han and Bing Yang and Liang Guo and Yuanzhu Zhang and Feng He and Leilei Tian}, doi = {10.1002/anie.202423023}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202423023}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The role of open-shell organic radical in enhancing anti-tumor photocatalysis reaction of NIR light-activated photosensitizer}, volume = {64}, year = {2025}, }
• (2025). Mapping dynamic protein clustering with AIEgen-active chemigenetic probe. ANGEW, 64(14), e202422996. (www)

  @article{ , abstract = {Protein clustering/disassembling is a fundamental process in biomolecular condensates, playing a crucial role in cell fate decision and cellular homeostasis. However, the inherent features of protein clustering, especially for its reversible behavior and subtle microenvironment variation, present significant hurdles in probe chemistry for tracking protein clustering dynamics. Herein, we report a bilateral-tailored chemigenetic probe, in which an “amphiphilic” aggregate-induced emission luminogen (AIEgen) QMSO 3 Cl is covalently conjugated to a protein tag that is genetically fused to protein-of-interest (POI). Prior to target POI, the “amphiphilic” AIE-active QMSO 3 Cl achieves a completely dark state in both aqueous biological environment and lipophilic organelles, thereby ensuring an ultra-low intrinsic background interference. Upon reaching POI, the combination of synthetic molecule and genetically encoded protein allows for protein clustering-dependent ultra-sensitive response, with a substantial lighting-up fluorescence (67.5-fold) as protein transitions from disassembling to clustering state. Such ultra-high signal-to-noise ratio enables to monitor the dynamic and fate of inositol requiring enzyme 1 (IRE1) clustering/disassembling under both acute and chronic endoplasmic reticulum (ER) stress in living cells. For the first time, we have demonstrated the use of chemigenetic probe to reveal therapy-induced ER stress and screen drugs in a three-dimensional scenario: microviscosity change, clustering dynamic, and cluster morphology. This chemigenetic probe design strategy would greatly facilitate the advancement of mapping protein dynamics in cell homeostasis and medicine research.}, archive = {J_ANGEW}, author = {Chenxu Yan and Wendi Zhu and Runqi Li and Qin Xu and Dan Li and Weixu Zhang and Ling Leng and Andong Shao and Zhiqian Guo}, doi = {10.1002/anie.202422996}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422996}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mapping dynamic protein clustering with AIEgen-active chemigenetic probe}, volume = {64}, year = {2025}, }
• (2025). Design of an ultrafast and controlled visible light-mediated photoiniferter RAFT polymerization for polymerization-induced self-assembly (PISA). ANGEW, 64(14), e202422975. (www)

  @article{ , abstract = {In this contribution, we designed a new xanthate RAFT agent by introducing (5,6,7,8-tetrahydro-2-naphthalenyl)oxy (TNO) as the Z group, namely 2-[(((5,6,7,8-Tetrahydro-2-naphthalenyl)oxycarbonothioyl)thio)ethyl propanoate] (TNXEP). Due to the presence of the TNO group, TNXEP enabled highly controlled and ultrafast photoiniferter RAFT polymerization under violet (λ=405 nm) and blue (λ=450 nm) light. This approach was effectively extended to aqueous media for polymerization-induced self-assembly (PISA), facilitating the synthesis of polymeric nanoparticles. Leveraging the rapid photolysis and extended absorption of TNXEP, we demonstrated the first photoiniferter PISA system realizing ultrafast polymerization (>90 % monomer conversion in minutes) under visible light irradiation. Enhanced visible light penetration improved photopolymerization uniformity, enabling rapid and scalable production of polymeric nanoparticles at a 30 g scale in just 10 minutes, with tunable morphologies, including spheres, worms, and vesicles.}, archive = {J_ANGEW}, author = {Zilong Wu and Zhengyan He and Yuchen Zhou and Tongtong Kou and Kaili Gong and Fuchun Nan and Terefe Tafese Bezuneh and Shiguo Han and Cyrille Boyer and William W. Yu}, doi = {10.1002/anie.202422975}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422975}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of an ultrafast and controlled visible light-mediated photoiniferter RAFT polymerization for polymerization-induced self-assembly (PISA)}, volume = {64}, year = {2025}, }
• (2025). Saturated f2-rings from alkenes. ANGEW, 64(14), e202422899. (www)

  @article{ , abstract = {A general method to convert simple exocyclic alkenes into saturated F 2 -rings has been developed. The reaction involves reagent C 6 F 5 I(OAc) 2 . The reaction efficiently works on the mg-, g-, and even multigram scale.}, archive = {J_ANGEW}, author = {Yin Li and Xiao-Bin Liu and Vadym Sham and Ivan Logvinenko and Jiang-Hao Xue and Jun-Yunzi Wu and Jia-Luo Fu and Shuang Lin and Yuan Liu and Qingjiang Li and Pavel K. Mykhailiuk and Honggen Wang}, doi = {10.1002/anie.202422899}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422899}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Saturated f2-rings from alkenes}, volume = {64}, year = {2025}, }
• (2025). Multi-targeting macrocyclic peptides as nanomolar inhibitors of self- and cross-seeded amyloid self-assembly of α-synuclein. ANGEW, 64(14), e202422834. (www)

  @article{ , abstract = {Amyloid self-assembly of α-synuclein (αSyn) is linked to the pathogenesis of Parkinson's disease (PD). Type 2 diabetes (T2D) has recently emerged as a risk factor for PD. Cross-interactions between their amyloidogenic proteins may act as molecular links. In fact, fibrils of islet amyloid polypeptide (IAPP) (T2D) can cross-seed αSyn amyloidogenesis and αSyn and IAPP colocalize in PD brains. Inhibition of both self- and IAPP-cross-seeded αSyn amyloidogenesis could thus interfere with PD pathogenesis. Here we show that macrocyclic peptides, designed to mimic IAPP self-/cross-interaction sites and previously found to inhibit amyloidogenesis of IAPP and/or Alzheimer's disease (AD) amyloid-β peptide Aβ40(42), are nanomolar inhibitors of both self- and IAPP-cross-seeded amyloid self-assembly of αSyn. Anti-amyloid function is mediated by nanomolar affinity interactions with αSyn via three αSyn regions which are identified as key sites of both αSyn self-assembly and its cross-interactions with IAPP. We also show that the peptides block Aβ42-mediated cross-seeding of αSyn as well. Based on their broad spectrum anti-amyloid function and additional drug-like features, these peptides are leads for multifunctional anti-amyloid drugs in PD, T2D, AD, and their comorbidities, while the identified αSyn key segments are valuable targets for novel, multi-site targeting amyloid inhibitors in PD and related synucleinopathies.}, archive = {J_ANGEW}, author = {Simon Hornung and Dominik P. Vogl and Denise Naltsas and Beatrice Dalla Volta and Markus Ballmann and Beatrice Marcon and Muhammed Muazzam Kamil Syed and Yiyang Wu and Anna Spanopoulou and Regina Feederle and Luzia Heidrich and Jürgen Bernhagen and Thomas Koeglsperger and Günter U. Höglinger and Gerhard Rammes and Hilal A. Lashuel and Aphrodite Kapurniotu}, doi = {10.1002/anie.202422834}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422834}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-targeting macrocyclic peptides as nanomolar inhibitors of self- and cross-seeded amyloid self-assembly of α-synuclein}, volume = {64}, year = {2025}, }
• (2025). Mesoporous single-crystal FeFe(CN)6 microspheres for superior potassium-ion storage. ANGEW, 64(14), e202422723. (www)

  @article{ , abstract = {Metal hexacyanoferrates (HCFs), also known as Prussian blue analogues, are ideal cathodes for potassium-ion batteries (PIBs) due to their nontoxicity and cost-effectiveness. Nevertheless, obtaining metal HCF cathode materials with both long-term cycling stability and high rate performance remains a daunting challenge. In this study, we present mesoporous single-crystalline iron hexacyanoferrate (MSC-FeHCF) microspheres, featuring a single-crystalline structure that contains interconnected pores spanning the entire crystal lattice. This unique architecture not only enables the electrolyte to fully penetrate into the single crystal, but also shorten the K + diffusion distance. Additionally, the confinement effect of mesopores on interior water mitigates the excessive side reactions. The stress during battery cycling can be dispersed through multiple paths to alleviate the internal strain. The MSC-FeHCF microspheres exhibit unprecedented long-term cycling performance, achieving a specific discharge capacity of 123.5 mAh g −1 at 30 mA g −1 and 87.1 mAh g −1 after 2000 cycles at 500 mA g −1 , providing 85.8 % of the initial capacity. More importantly, the MSC-FeHCF microspheres exhibit high rate capability, delivering 86.7 mAh g −1 at 3 A g −1 . This study introduces an innovative strategy for engineering metal HCF cathode materials, thereby opening a novel avenue for the development of high-efficiency electrode materials for PIBs.}, archive = {J_ANGEW}, author = {Yifan Xu and Yichen Du and Lili Song and Shilin Zhang and Zeyu Yuan and Jie Wang and Huining Liu and Liang Sun and Xiaosi Zhou and Zaiping Guo}, doi = {10.1002/anie.202422723}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422723}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mesoporous single-crystal FeFe(CN)6 microspheres for superior potassium-ion storage}, volume = {64}, year = {2025}, }
• (2025). W-mediated electron accumulation in Ru−O−W motifs enables ultra-stable oxygen evolution reaction in acid. ANGEW, 64(14), e202422707. (www)

  @article{ , abstract = {The development of efficient and durable oxygen evolution reaction (OER) catalysts is crucial for advancing proton exchange membrane water electrolysis (PEMWE) technology, especially in the pursuit of non-iridium alternatives. Herein, we report a Zn, W co-doped Ru 3 Zn 0.85 W 0.15 O x (RZW) ternary oxide catalyst that exhibits a low overpotential of 200 mV and remarkable stability for over 4000 hours at 10 mA cm −2 in 0.1 M HClO 4 . The incorporation of highly electronegative W facilitates the efficient capture of electrons released from the sacrificial Zn species during OER, and subsequently mediated to Ru sites. The observed enhancement in electron density within the stable Ru−O−W motifs substantially improves the anti-overoxidation properties of the Ru active sites. Our findings highlight the importance of strategic metal doping in modulating the electronic structure of OER catalysts during operation, thereby facilitating the development of practical and long-lasting water electrolysis technologies.}, archive = {J_ANGEW}, author = {Kai Zhou and Heng Liu and Zhongliang Liu and Xiaoning Li and Nana Wang and Mingyue Wang and Tianrui Xue and Yongjun Shen and Hao Li and Huihui Li and Chunzhong Li}, doi = {10.1002/anie.202422707}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {W-mediated electron accumulation in Ru−O−W motifs enables ultra-stable oxygen evolution reaction in acid}, volume = {64}, year = {2025}, }
• (2025). Towards surface-enhanced homogeneous catalysis: Tailoring the enrichment of metal complexes at ionic liquid surfaces. ANGEW, 64(14), e202422693. (www)

  @article{ , abstract = {When talking about homogeneous catalyst systems, it has long been assumed that the system at hand consists of a transition metal complex in solution with the liquid interface representing the composition of the bulk solution. Now, in light of considerable developments in the study of metal complexes dissolved in ionic liquids with their negligible vapor pressures, more detailed studies of the composition at the liquid/gas interface became possible. These investigations revealed pronounced surface enrichment and segregation effects of high relevance for practical applications. This article reviews recent advancements in tailoring the interfacial composition of ionic liquid-based catalytic systems. A particular focus is dedicated to surface enrichment phenomena, and a variety of parameters are presented for deliberate control of the local concentration of the complexes at the surface, that is, the nature of the ligands, the bulk concentration, the temperature, and the nature of the IL solvent. As experimental methods, angle-resolved X-ray photoelectron spectroscopy (ARXPS) and vacuum-based pendant-drop surface tension measurements were applied. The reviewed results are intended to provide the basis for the advancement of catalytic systems with high surface areas, such as in supported ionic liquid phase (SILP) catalysis, where the interface design is directly interconnected with catalytic performance.}, archive = {J_ANGEW}, author = {Daniel Hemmeter and Marco Haumann and Federico J. Williams and Thomas M. Koller and Peter Wasserscheid and Karsten Meyer and Florian Maier and Hans-Peter Steinrück}, doi = {10.1002/anie.202422693}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422693}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards surface-enhanced homogeneous catalysis: Tailoring the enrichment of metal complexes at ionic liquid surfaces}, volume = {64}, year = {2025}, }
• (2025). Impact of pressure on metavalent bonding in BiTe influencing electronic topological transitions. ANGEW, 64(14), e202422652. (www)

  @article{ , abstract = {BiTe, a member of the (Bi 2 ) m (Bi 2 Te 3 ) n homologous series, possesses natural van der Waals-like heterostructure with a Bi 2 bilayer sandwiched between the two [Te−Bi−Te−Bi−Te] quintuple layers. BiTe exhibits both the quantum states of weak topological and topological crystalline insulators, making it a dual topological insulator and a suitable candidate for spintronics, quantum computing and thermoelectrics. Herein, we demonstrate that the chemical bonding in BiTe is to be metavalent, which plays a significant role in the pressure dependent change in the topology of the electronic structure Fermi surface. The enhancement of the metavalent bonding character with pressure in BiTe is evidenced from first-principles density functional theory (DFT) calculations. Due to the change in the Fermi surface topology, we have visualized electronic topological transitions (ETT) at ~1 and ~3 GPa through pressure dependent synchrotron X-ray diffraction analysis and Raman spectroscopy. The correlation between the metavalent bonding and ETT offers insights into chemical bonding influenced transitions in quantum materials.}, archive = {J_ANGEW}, author = {Riddhimoy Pathak and Anjana Joseph and Prabir Dutta and Boby Joseph and Jyoti Duhan and Sushmita Chandra and Chandrabhas Narayana and Koushik Pal and Kanishka Biswas}, doi = {10.1002/anie.202422652}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422652}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Impact of pressure on metavalent bonding in BiTe influencing electronic topological transitions}, volume = {64}, year = {2025}, }
• (2025). Ruthenium-catalyzed deconstruction of polyolefins: A strategy to up-cycle waste polyethylene to value-added alkene. ANGEW, 64(14), e202422609. (www)

  @article{ , abstract = {Synthesis of value-added products from post-consumer waste polyolefins is fascinating as well as challenging. Here we report ruthenium-catalyzed up-cycling of the polyethylene to long-chain alkene derivatives. The developed methodology mainly involves two steps i.e., dehydrogenation of polyethylene through hydrogen atom transfer and its metathesis using the HG-II catalyst. The dehydrogenation of polyethylene using ruthenium catalysis derived up to 3.38 %, of double bonds; with 90 % of the recovered polyolefin material. The obtained unsaturated polyethylene was subjected to cross-metathesis with ethylene using HG-II catalytic system. This resulted in the synthesis of predominantly dodecene (C12) derivatives, with 58 % selectivity, along with other derivatives of varying chain lengths. The overall reaction produced terminal and internal olefins in the ratio 1:0.8 respectively. The dehydrogenation of polyethylene and its deconstruction was confirmed by NMR spectroscopy, Gel Permeation Chromatography (GPC) and Differential Scanning Calorimetry (DSC). The origin of C12 selectivity has been demonstrated by control experiments. The scope of the methodology was extended to post-consumer waste polyethylene which gave high conversion to value-added dodecene derivatives as a major product.}, archive = {J_ANGEW}, author = {Ganeshdev Padhi and Kishor V. Khopade and Nageswararao Moyilla and Raghavendrakumar Rangappa and Samir H. Chikkali and Nagaraju Barsu}, doi = {10.1002/anie.202422609}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422609}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ruthenium-catalyzed deconstruction of polyolefins: A strategy to up-cycle waste polyethylene to value-added alkene}, volume = {64}, year = {2025}, }
• (2025). Supramolecular switching of liquid-liquid phase separation for orchestrating enzyme kinetics. ANGEW, 64(14), e202422601. (www)

  @article{ , abstract = {Dynamic liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) and associated assembly and disassembly of biomolecular condensates play crucial roles in cellular organization and metabolic networks. These processes are often regulated by supramolecular interactions. However, the complex and disordered structures of IDPs, coupled with their rapid conformational fluctuations, pose significant challenges for reconstructing supramolecularly-regulated dynamic LLPS systems and quantitatively illustrating variations in molecular interactions. Inspired by the structural feature of IDPs that facilitates LLPS, we designed a simplified phase-separating molecule, Nap-o-Nap , consisting of two naphthalene moieties linked by an ethylene glycol derivative. This compound exhibits LLPS under physiological conditions, forming coacervate microdroplets that undergo multiple cycles of disassembly and reassembly upon stoichiometric addition of Cucurbit[7]uril and Adamantane, respectively, based upon competitive host–guest interactions. Importantly, such reversible control offers a unique route to quantify entropically dominant nature (Δ S =14.0 cal ⋅ mol −1 ⋅ K −1 ) within the LLPS process, in which the binding affinity of host–guest interactions (Δ G =−14.9 kcal ⋅ mol −1 ) surpass that of the LLPS of Nap-o-Nap (Δ G =−2.1 kcal ⋅ mol −1 ), enabling the supramolecular regulation process. The supramolecularly switched LLPS, along with selective client recruitment and exclusion by resultant coacervates, provides a promising platform for either boosting or retarding enzymatic reactions, thereby orchestrating biological enzyme kinetics.}, archive = {J_ANGEW}, author = {Deyi Wang and Lingying Zhou and Xiaokun Zhang and Zixiang Zhou and Zehuan Huang and Ning Gao}, doi = {10.1002/anie.202422601}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422601}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular switching of liquid-liquid phase separation for orchestrating enzyme kinetics}, volume = {64}, year = {2025}, }
• (2025). Retrieving the stability and practical performance of activation-unstable mesoporous Zr(IV)-MOF for highly efficient self-calibrating acidity sensing. ANGEW, 64(14), e202422517. (www)

  @article{ , abstract = {The practical applications of activation-unstable mesoporous metal-organic frameworks (MOFs) are often constrained by their structural instability. However, enhancing their stability could unlock valuable functionalities. Herein, we stabilized the otherwise unstable, post-activated structure of a novel mesoporous Zr(IV)-MOF, NKM-809, which constructed from a pyridine-containing amphiprotic linker (PPTB). We applied two strategies: mixed-linker synthesis and linker installation. In the mixed-linker approach, we incorporated an auxiliary linker, TPTB, which resembles PPTB, during synthesis to improve the framework's stability. In the linker installation approach, we introduced a ditopic carboxylate linker (BPDC) into the coordination-unsaturated sites of NKM-809. These strategies produced stabilized derivatives, named NKM-808.X (X=χ PPTB ) and NKM-809-BPDC, which exhibit pH-responsive dual-wavelength fluorescence at distinct emission wavelengths. Remarkably, these emissions shift oppositely upon protonation and dissociation, distinguishing them as highly sensitive, self-calibrating acidity sensors. In NKM-809-BPDC, an additional quenching of the linker-emission (419 nm) minimizes inherent interference, enabling integrated quality and lifespan self-monitoring. Theoretical calculations identified transitions between (n, π*) and (π, π*) emission states during the sensing process and highlighted the role of a stable mesoporous network in achieving stronger protonation response. These findings showcase the potential of stabilized mesoporous MOFs for practical applications, alongside valuable insights into strategies for optimizing such materials.}, archive = {J_ANGEW}, author = {Feifan Lang and Lulu Zhang and Yang Li and Xiao-Juan Xi and Jiandong Pang and Wenjun Zheng and Hong-Cai Zhou and Xian-He Bu}, doi = {10.1002/anie.202422517}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422517}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Retrieving the stability and practical performance of activation-unstable mesoporous Zr(IV)-MOF for highly efficient self-calibrating acidity sensing}, volume = {64}, year = {2025}, }
• (2025). Accelerating tumor immunotherapy through a synergistic strategy of increasing throttle and relaxing brake. ANGEW, 64(14), e202422502. (www)

  @article{ , abstract = {Tumor immunotherapy has been widely used clinically, but it is still hindered by weak antitumor immunity and immunosuppressive tumor microenvironment (TME). Here, a kind of simple disodium hydrogen phosphate nanoparticle (Na 2 HPO 4 NP) is prepared to “accelerate” tumor immunotherapy by “increasing throttle” and “relaxing brake” simultaneously. The obtained Na 2 HPO 4 NPs release a large amount of Na + and HPO 4 2− ions within tumor cells, thereby activating the caspase 1/GSDMD-mediated pyroptosis pathway to achieve immune activation. Meanwhile, alkalescent Na 2 HPO 4 NPs can further consume lactic acid through acid-base neutralization, and regulate adenosine (Ado) metabolism via nanomaterial-induced biocatalytic process to relieve two-tier immunosuppression. Collectively, Na 2 HPO 4 NPs effectively activate the antitumor immune process in vivo, and dramatically inhibit primary and distal tumor growth. This work will provide unique inspiration and strategy for the regulation of both positive and negative directions in immunotherapy.}, archive = {J_ANGEW}, author = {Binbin Ding and Jing Li and Jia Tan and Hao Chen and Pan Zheng and Ping'an Ma and Jun Lin}, doi = {10.1002/anie.202422502}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerating tumor immunotherapy through a synergistic strategy of increasing throttle and relaxing brake}, volume = {64}, year = {2025}, }
• (2025). Bias-free solar-driven ammonia coupled to c3-dihydroxyacetone production through photoelectrochemistry. ANGEW, 64(14), e202422443. (www)

  @article{ , abstract = {Conversion of solar energy into value-added chemicals through photoelectrochemistry (PEC) holds great potential for advancing sustainable development but limits by high onset potential which affects energy conversion efficiencies. Herein, we utilized a CuPd cocatalyst-modified Sb 2 (S,Se) 3 photocathode (CuPd/TSSS) to achieve an ultra-low onset potential of 0.83 V RHE for photoelectrochemical ammonia synthesis. Meanwhile, we achieved unbiased NH 3 production by synthesizing major value-added C 3 -dihydroxyacetone (DHA) through glycerol oxidation on the BiVO 4 photoanode with the loading Pd cocatalyst, instead of a traditional solar water oxidation reaction. The PEC integrated system stably produced 11.98 μmol cm −2 of NH 3 and 201.9 mmol m −2 of DHA over 5 h with ~80 % faradaic efficiency without applying additional bias. In situ analysis and theoretical calculations confirmed high catalytic activity for ammonia synthesis at the CuPd/TSSS photocathode and enhanced selectivity for DHA at the Pd/BiVO 4 photoanode. This design represents a breakthrough in directly utilizing solar energy, nitrate-containing wastewater, and biomass waste for ammonia and highly value-added C 3 production, which addresses increasing energy demands while decreasing environmental impact.}, archive = {J_ANGEW}, author = {Kerong Su and Shijie Ren and Rui-Ting Gao and Guang-En Bai and Limin Wu and Lei Wang}, doi = {10.1002/anie.202422443}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422443}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bias-free solar-driven ammonia coupled to c3-dihydroxyacetone production through photoelectrochemistry}, volume = {64}, year = {2025}, }
• (2025). Broad-temperature optical thermometry via dual sensitivity of self-trapped excitons lifetime and higher-order phonon anharmonicity in lead-free perovskites. ANGEW, 64(14), e202422424. (www)

  @article{ , abstract = {Broad-temperature optical thermometry necessitates materials with exceptional sensitivity and stability across varied thermal conditions, presenting challenges for conventional systems. Here, we report a lead-free, vacancy-ordered perovskite Cs 2 TeCl 6 , that achieves precise temperature sensing through a novel combination of self-trapped excitons (STEs) photoluminescence (PL) lifetime modulation and unprecedented fifth-order phonon anharmonicity. The STEs PL lifetime demonstrates a highly temperature-sensitive response from 200 to 300 K, ideal for low-to-intermediate thermal sensing. In contrast, the E g phonon mode undergoes significant linewidth broadening due to five-phonon scattering processes, with a distinct nonlinear temperature dependence up to 500 K. This fifth-order anharmonic effect enhances Raman-based temperature sensitivity, yielding a specific sensitivity (Sr) of 0.577 % K –1 at 330 K and remaining above 0.5 % K –1 at elevated temperatures. This study presents the first evidence of fifth-order anharmonic effects enhancing Raman-based temperature sensitivity, establishing Cs 2 TeCl 6 as a versatile candidate for broad-temperature optical thermometry and opening new avenues for precise non-contact temperature sensing in advanced technological applications.}, archive = {J_ANGEW}, author = {Guangming Niu and Jutao Jiang and Xiangyu Zeng and Xin Liu and Xiaowei Wang and Yutong Zhang and Li Che and Laizhi Sui and Guorong Wu and Kaijun Yuan and Xueming Yang}, doi = {10.1002/anie.202422424}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422424}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Broad-temperature optical thermometry via dual sensitivity of self-trapped excitons lifetime and higher-order phonon anharmonicity in lead-free perovskites}, volume = {64}, year = {2025}, }
• (2025). Dehydration-enhanced ion recognition of triazine covalent organic frameworks for high-resolution Li+/Mg2+ separation. ANGEW, 64(14), e202422423. (www)

  @article{ , abstract = {The precise and rapid extraction of lithium from salt-lake brines is critical to meeting the global demand for lithium resources. However, it remains a major challenge to design ion-transport membranes with accurate recognition and fast transport path for the target ion. Here, we report a triazine covalent organic framework (COF) membrane with high resolution for Li + and Mg 2+ that enables fast Li + transport while almost completely inhibiting Mg 2+ permeation. The remarkably high rejection of Mg 2+ by the COF membrane is achieved via imposed ion dehydration and the construction of the energy well. The proper hydrophilic environment of the COF channel promotes the dissociation of Li + from the negatively charged functional groups, allowing Li + for hopping transport supported by the sulfonate side-chains to shorten the diffusion path of Li + . Under high-salinity electrodialysis conditions, the COF membrane demonstrates robust Li + /Mg 2+ separation performance (No Mg 2+ were detected in the collected solution), achieving efficient lithium recovery and high product purity (Li 2 CO 3 : 99.3 %). This membrane design strategy enables high energy efficiency and powerful lithium extraction in the electrodialysis lithium extraction process, and can be generalized to other energy and separation related membranes.}, archive = {J_ANGEW}, author = {Wentong Meng and Sifan Chen and Ming Wu and Feng Gao and Yang Hou and Xiaoli Zhan and Wei Hu and Lijun Liang and Qinghua Zhang}, doi = {10.1002/anie.202422423}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422423}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dehydration-enhanced ion recognition of triazine covalent organic frameworks for high-resolution Li+/Mg2+ separation}, volume = {64}, year = {2025}, }
• (2025). Aluminadichalcogeniranes and aluminatrichalcogenetanes: Heavier analogs of dioxiranes and trioxetanes. ANGEW, 64(14), e202422335. (www)

  @article{ , abstract = {Dioxiranes and their heavier chalcogen analogs have long been recognized as pivotal reagents and intermediates in synthetic chemistry, while trioxetanes have largely remained theoretical constructs. In this work, we present the synthesis of neutral, isoelectronic aluminum/chalcogen analogs of dioxiranes and trioxetanes, specifically aluminadiselenirane, aluminaditellurirane, aluminatriselenetane, aluminatritelluretane, and a mixed Se/Te analog of aluminatrichalcogenetane. These compounds, featuring strained AlCh 2 and AlCh 3 ring (Ch=Se, Te), exhibit significant polarization between the aluminum and chalcogen components. Reactivity studies have revealed that both aluminadiselenirane and aluminaditellurirane show pronounced ambiphilic behavior when interacting with proximal substrates, undergoing facile ring-opening (cyclo)additions. Additionally, the coordination chemistry of aluminatriselenetane with a Lewis acid has been documented. These investigations not only broaden the repertoire of unique main group species but also provide access to heterocyclic structures that present synthetic challenges through conventional methods.}, archive = {J_ANGEW}, author = {Xin Zhang and Lingbing Kong and Liu Leo Liu}, doi = {10.1002/anie.202422335}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422335}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aluminadichalcogeniranes and aluminatrichalcogenetanes: Heavier analogs of dioxiranes and trioxetanes}, volume = {64}, year = {2025}, }
• (2025). AA-stacked hydrogen-substituted graphdiyne for enhanced lithium storage. ANGEW, 64(14), e202422089. (www)

  @article{ , abstract = {Graphdiyne (GDY) has been considered a promising electrode material for application in electrochemical energy storage. However, studies on GDY featuring an ordered interlayer stacking are lacking, which is supposed to be another effective way to increase lithium binding sites and diffusion pathways. Herein, we synthesized a hydrogen-substituted GDY (HsGDY) with a highly-ordered AA-stacking structure via a facile alcohol-thermal method. Such unique architecture enables a rapid lithium transfer through the well-organized pore channels and endows a stronger adsorption capability to lithium atom as compared to the arbitrarily-stacked mode. The resultant HsGDY exhibits a reversible capacity of 1040 mA h g −1 at 0.05 A g −1 ranking among the most powerful GDY-based electrode materials, and an excellent rate performance as well as a long-term cycling stability. The successful preparation of gram-level high-quality HsGDY products in batches implies the potential for large-scale lithium-storage applications.}, archive = {J_ANGEW}, author = {Yuanyuan Liu and Zhengrun Chen and Chenyu Lai and Xiang Li and Zhou Qu and Chunxi Li and Manhua Peng and Hongwei Fan and Fei Ding and Lin Zhang}, doi = {10.1002/anie.202422089}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422089}, shortjournal = {Angew. Chem. Int. Edit.}, title = {AA-stacked hydrogen-substituted graphdiyne for enhanced lithium storage}, volume = {64}, year = {2025}, }
• (2025). Highly tension-strained copper concentrates diluted cations for selective proton-exchange membrane CO2 electrolysis. ANGEW, 64(14), e202422054. (www)

  @article{ , abstract = {Electrolysis of carbon dioxide (CO 2 ) in acid offers a promising route to overcome CO 2 loss in alkaline and neutral electrolytes, but requires concentrated alkali cations (typical ≥3 M) to mitigate the trade-off between low pH and high hydrogen evolution reaction (HER) rate, causing salt precipitation. Here we report a strategy to resolve this problem by introducing tensile strain in a copper (Cu) catalyst, which can selectively reduce CO 2 to valuable multicarbon products, particularly ethylene, in a pH 1 electrolyte with 1 M potassium ions. We find that the tension-strained Cu creates an electron-rich surface that concentrates diluted potassium ions, contributing to CO 2 activation and HER suppression. With this catalyst, we show constant ethylene Faradaic efficiency (FE) of 44.3 % over 100 hours at 400 mA cm −2 and a cell voltage of 3.1 volts in a proton-exchange membrane electrolyser. Moreover, selective electrosynthesis of ethylene oxide using the as-produced ethylene was demonstrated in an integrated system.}, archive = {J_ANGEW}, author = {Ye-Cheng Li and Xiao-Long Zhang and Xiao-Lin Tai and Xue-Peng Yang and Peng-Cheng Yu and Shi-Chen Dong and Li-Ping Chi and Zhi-Zheng Wu and Yu-Cai Zhang and Shu-Ping Sun and Pu-Gan Lu and Lei Zhu and Fei-Yue Gao and Yue Lin and Min-Rui Gao}, doi = {10.1002/anie.202422054}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly tension-strained copper concentrates diluted cations for selective proton-exchange membrane CO2 electrolysis}, volume = {64}, year = {2025}, }
• (2025). Hierarchical interface enabled by a guest-anionic chemistry for high-rate aqueous zinc-ion batteries. ANGEW, 64(14), e202422036. (www)

  @article{ , abstract = {The poor reversibility of the zinc anode caused by interfacial side reactions and dendritic growth poses significant constraints on the practical application of aqueous zinc-ion batteries. Herein, a co-solute, acesulfame potassium, with strongly polar, zincophilic guest anions is introduced into a conventional low-concentration aqueous electrolyte. This regulation enhances the electrolyte‘s ionic conductivity and accelerates the desolvation process of zinc ions at the electrode/electrolyte interface. Furthermore, the introduced acesulfame anions give rise to the formation of a stable solid electrolyte interface with a hierarchical crystalline-amorphous bilayer structure that effectively suppresses side reactions and allows for uniform zinc ion diffusion-deposition. Results show that the zinc anode in the designed electrolyte possesses remarkable reversibility, achieving stable operation under a ultrahigh current density of 40 mA cm −2 and 67.6 % depth of discharge, surpassing most previous reports. Zn//I 2 full cells assembled with this electrolyte exhibit high rate capability (135.0 mAh g −1 at 20 A g −1 ) and remarkable lifespan (96.3 % capacity retention after 40,000 cycles at 10 A g −1 ). A large-sized Zn//I 2 pouch cell is also demonstrated, delivering a total capacity of 170 mAh with 78.8 % capacity retention after 600 cycles at 3.3 mA cm −2 , highlighting the potential of the guest-anionic chemistry in practical applications.}, archive = {J_ANGEW}, author = {Guangmeng Qu and Yongzheng Zhao and Chuanlin Li and Yanjun Zhai and Yueyue Kong and Xiyu He and Lingtong Kong and Chang Wang and Ming Chen and Kepeng Song and Zhuoxin Liu and Liqiang Xu}, doi = {10.1002/anie.202422036}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422036}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hierarchical interface enabled by a guest-anionic chemistry for high-rate aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Light-induced enhancement of energetic charge carrier extraction and modulation of local charge density to impact selectivity in plasmonic nanometals. ANGEW, 64(14), e202422034. (www)

  @article{ , abstract = {Localized surface plasmon resonance (LSPR) metals exhibit remarkable light-absorbing property and unique catalytic activity, attracting significant attention in photocatalysts recently. However, the practical application of plasmonic nanometal is hindered by challenge of energetic electrons extraction and low selectivity. The energetic carriers generated in nanometal under illumination have extremely short lifetimes, leading to rapid energy loss. In this work, silver nanometals modified with five distinct sulfhydryl ligands (re-Ag-S-R) were synthesized via photoreduction of superlattice precursors. Modified surface efficiently extracts and preserves excited state electrons of plasmonic nanometals. By modulation the local charge density at catalytic active sites through substituents with varying electron-donating and electron-withdrawing properties, the selectivity of the photocatalytic carbon dioxide reduction reaction and hydrogen evolution reaction was influenced. The results demonstrated opposite selectivity between methoxy-modified re-Ag-S-OCH 3 (CO selectivity of 96.73 %) and amino-modified re-Ag-S-NH 2 (H 2 selectivity of 96.66 %) despite their similar structures. The changes in excited states and surface contact potentials induced by LSPR were monitored using femtosecond transient absorption (fs-TA) spectroscopy and Kelvin probe force microscopy (KPFM). Meanwhile, the detailed discussion of the LSPR mechanism in plasmonic nanometals will serve as valuable references and foundational elements for future research in this area.}, archive = {J_ANGEW}, author = {Yanjun Liu and Xingyue He and Xiao Liu and Bo Li and Jian-Gong Ma and Peng Cheng}, doi = {10.1002/anie.202422034}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202422034}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-induced enhancement of energetic charge carrier extraction and modulation of local charge density to impact selectivity in plasmonic nanometals}, volume = {64}, year = {2025}, }
• (2025). Synergistic electrode and electrolyte polarities lead to outstanding organic potassium-based batteries. ANGEW, 64(14), e202421928. (www)

  @article{ , abstract = {Organic materials are promising as battery electrodes due to their flexible design, low cost, and sustainability. Although high electrolyte concentrations are known to suppress organic cathode dissolution, the organic cathode solubility depends on the interplay between the electrode and electrolyte polarities, which remains unexplored. Here, we elucidate the delicate interplay of electrode and electrolyte polarities to achieve stable cycling of organic cathode. Notably, we demonstrate that the solubility of low-polar organic cathodes initially increases and subsequently decreases in electrolytes with increasing polarity. In contrast, high-polar organic cathodes display increasing solubility in electrolytes with increasing polarity. When the polarities of the organic cathodes and the electrolyte are tuned, the batteries show high-capacity retention and Coulombic efficiency. For example, polyaniline||potassiated graphite (KC 8 ) pouch cells deliver 2500 cycles with an average Coulombic efficiency of 99.85 %. These new insights into low- and high-polar organic cathode behavior in electrolytes lay a theoretical foundation for designing new organic battery electrodes and optimizing their electrolyte formulation.}, archive = {J_ANGEW}, author = {Binyu Gui and Xiaoteng Yang and Hongwei Fu and Peng Peng and Wang Lyu and Apparao M. Rao and Jiang Zhou and Ling Fan and Bingan Lu}, doi = {10.1002/anie.202421928}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202421928}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic electrode and electrolyte polarities lead to outstanding organic potassium-based batteries}, volume = {64}, year = {2025}, }
• (2025). Molecular design for dual circularity: Polyester with complementary mechanical and chemical recyclability under mild conditions. ANGEW, 64(14), e202421431. (www)

  @article{ , abstract = {The plastic waste accumulation requires facile yet effective solutions. Currently mechanical recycling typically leads to downcycling, while the environmental footprint of chemical recycling is often unacceptable. Here, we introduce a dual circularity concept, where rational molecular design paves the way for complementary closed-loop mechanical and chemical recyclability under mild conditions. Very small changes in macromolecular structures, thermal and mechanical properties were observed, after as many as six repeated mechanical recycling cycles, showing that a wide processing window could be the key for closing the mechanical recycling loop. Facile, time and energy efficient closed-loop chemical recycling into products with identical performance to original ones was also realized, thanks to the abundant free volume and accessible ester-functionalities. With these design criteria at hand, dual circulation in recyclability can be realized; proceeding with mechanical recycling when we can, and switching to chemical recycling when we must.}, archive = {J_ANGEW}, author = {Yue Han and Pingxia Zhang and Heng Zhou and Tong Zhao and Karin Odelius and Minna Hakkarainen}, doi = {10.1002/anie.202421431}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202421431}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular design for dual circularity: Polyester with complementary mechanical and chemical recyclability under mild conditions}, volume = {64}, year = {2025}, }
• (2025). High-performance intrinsically-stretchable organic solar cells enabled by electron acceptors with flexible linkers. ANGEW, 64(14), e202421430. (www)

  @article{ , abstract = {Intrinsically stretchable organic solar cells (IS-OSCs) are emerging as promising candidates for powering next-generation wearable electronics. However, developing molecular design strategies to achieve both high efficiency and mechanical robustness in IS-OSCs remains a significant challenge. In this work, we present a novel approach by synthesizing a dimerized electron acceptor (DY-FBrL) that enables rigid OSCs with a high power conversion efficiency (PCE) of 18.75 % and a crack-onset strain (COS) of 18.54 %. The enhanced PCE and stretchability of DY-FBrL-based devices are attributed to its extended π-conjugated backbone and elongated side chains. Furthermore, we introduce an innovative polymerized acceptor (PDY-FL), synthesized via the polymerization of DY-FBrL. While PDY-FL-based devices exhibit a slightly lower PCE of 14.13 %, they achieve a significantly higher COS of 23.45 %, representing one of the highest PCEs reported for polymerized acceptors containing only flexible linkers. Consequently, IS-OSCs fabricated using DY-FBrL and PDY-FL achieve notable PCEs of 14.31 % and 11.61 %, respectively. Additionally, the device stretchability improves progressively from Y6 (strain at PCE 80% =11 %), to DY-FBrL (strain at PCE 80% =23 %), and PDY-FL (strain at PCE 80% =31 %). This study presents a promising molecular design strategy for tailoring electron acceptor structures, offering a new pathway to develop high-performance IS-OSCs with enhanced mechanical properties.}, archive = {J_ANGEW}, author = {Yafei Ding and Shilong Xiong and Waqar Ali Memon and Di Zhang and Zhi Wang and Mingpeng Li and Zihao Deng and Heng Li and Ming Shao and Feng He}, doi = {10.1002/anie.202421430}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202421430}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance intrinsically-stretchable organic solar cells enabled by electron acceptors with flexible linkers}, volume = {64}, year = {2025}, }
• (2025). High-energy-density li-CO2 battery at elevated temperatures: Advances with fluorine-substituted graphdiyne and ionic liquid. ANGEW, 64(14), e202420892. (www)

  @article{ , abstract = {Li-CO 2 batteries demonstrate promising prospects in terms of high-density energy storage and efficient CO 2 fixation. However, their practical application is impeded by sluggish reaction kinetics and leakage of volatile and flammable organic electrolytes, especially for high temperature application scenarios, leading to large polarization and limited cycling stability. Herein, we fabricate a highly rechargeable and stable Li-CO 2 battery with high temperature adaptability by employing fluorine-substituted graphdiyne (FGDY) as cathode catalysts and imidazolium-based ionic liquid as electrolyte solvents. The employed FGDY, which possesses homogeneous sp-hybridized carbon, high specific surface area, and uniform pores, significantly enhances the battery reaction kinetics. Consequently, the fabricated Li-CO 2 batteries operate consistently at a large current density of 5.0 A⋅g −1 at 80 °C while showcasing high discharge capacity of 29050 mAh⋅g −1 along with excellent cycling stability. As proof of concept, Li-CO 2 pouch cells achieve a high energy density of 536 Wh⋅kg −1 based on the total mass of the device, and show outstanding cycling stability at 80 °C. This study underscores the effectiveness of graphdiyne-derived carbon catalysts in achieving high-performance Li-CO 2 batteries.}, archive = {J_ANGEW}, author = {Junxiang Zhang and Ding Ding and Qisheng Fang and Jianli Cheng and Heyu Xiao and Bin Wang}, doi = {10.1002/anie.202420892}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202420892}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-energy-density li-CO2 battery at elevated temperatures: Advances with fluorine-substituted graphdiyne and ionic liquid}, volume = {64}, year = {2025}, }
• (2025). Fluorescent artificial receptor for dopamine based on molecular recognition-driven dynamic covalent chemistry in a lipid nanoreactor. ANGEW, 64(14), e202419905. (www)

  @article{ , abstract = {Molecular recognition and detection of small bioactive molecules, like neurotransmitters, remain a challenge for chemists, whereas nature found an elegant solution in the form of protein receptors. Here, we introduce a concept of a dynamic artificial receptor that synergically combines molecular recognition with dynamic imine bond formation inside a lipid nanoreactor, inducing a fluorescence response. The designed supramolecular system combines a lipophilic recognition ligand derived from a boronic acid, a fluorescent aldehyde based on push-pull styryl pyridine and a phenol-based catalyst. The recognition ligand specifically captures dopamine inside lipid nanodroplets and thus triggers imine bond formation with the aldehyde, producing the emission color change. The rational design of the fluorescent aldehyde, the catalyst, and the recognition ligand allows dramatic acceleration of the imine bond formation required for rapid sensing of dopamine. The nanoprobe enables dopamine detection with micromolar sensitivity and singe-nanoprobe imaging of dopamine gradients through its robust two-color ratiometric response. It displays remarkable selectivity without the interference of competing biogenic primary amines and biological media: blood serum, plasma, urine and cell lysate. The proposed concept of a dynamic artificial receptor offers a solution to the long-standing problem of molecular recognition and sensing of small molecules in complex biological media.}, archive = {J_ANGEW}, author = {Bohdan Kozibroda and Jean-Marie Lehn and Andrey S. Klymchenko}, doi = {10.1002/anie.202419905}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202419905}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorescent artificial receptor for dopamine based on molecular recognition-driven dynamic covalent chemistry in a lipid nanoreactor}, volume = {64}, year = {2025}, }
• (2025). Zinc coordination-polymer-mediated self-assembly of nanoparticles into “Brick-and-mortar” membranes for hydrogen separation. ANGEW, 64(14), e202416919. (www)

  @article{ , abstract = {Zeolitic imidazolate framework-8 (ZIF-8) with high stability and porosity is a promising candidate for hydrogen separation membranes. However, most ZIF-8 polycrystalline membranes exhibit low H 2 /CO 2 (kinetic diameters of 2.9/3.3 Å) mixed gas selectivity, due to the intercrystalline defects and the unprecise molecular sieving originated from framework flexibility of ZIF-8 structure with a theoretical aperture size of 3.4 Å. Here, inspired by nacre's “brick-and-mortar” structure, we develop mixed matrix type composite membranes in which dominant crystalline ZIF-8 nanoparticles (bricks) are interconnected by ultrathin zinc coordination polymer interlayers (mortar) via self-assembling. Driven by coordination bonds between Zn 2+ from precursor colloid and branched polyethyleneimine (PEI), a zinc coordination polymer network is formed to connect ZIF-8 nanoparticles through interactions between Zn 2+ of coordination polymer and surface terminal groups on ZIF-8 nanoparticles, thus eliminating intercrystalline void defects and providing a highly selective H 2 transport pathway. Meanwhile, the micropores and large cavities in ZIF-8 allow fast H 2 transport. Benefitting from both highly selective pathway and fast H 2 transport through porous ZIF-8, the optimized ZIF-8-PEI membrane exhibits a record-high H 2 permeability of ~1.78×10 5 Barrer with a high mixed gas H 2 /CO 2 selectivity of 176, surpassing state-of-the-art performance. This bioinspired multifunctional membrane expands the scope of molecular sieving membrane.}, archive = {J_ANGEW}, author = {Xinxin Li and Chengli Jiao and Xiaoqian Zhang and Xiaoya Xu and Saeed Gul and Fangyi Liang and Jürgen Caro and Heqing Jiang}, doi = {10.1002/anie.202416919}, journal = {Angewandte Chemie International Edition}, month = {4}, number = {14}, pages = {e202416919}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zinc coordination-polymer-mediated self-assembly of nanoparticles into “Brick-and-mortar” membranes for hydrogen separation}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Electrochemical CO2 fixation and release cycle featuring a trinuclear zinc complex for direct air capture. ANGEW, 64(13), e202581361. (www)

  @article{ , archive = {J_ANGEW}, author = {Masakazu Murase and Naonari Sakamoto and Takeshi Uyama and Takamasa Nonaka and Masataka Ohashi and Shunsuke Sato and Takeo Arai and Toshiyuki Itoh}, doi = {10.1002/anie.202581361}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202581361}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Electrochemical CO2 fixation and release cycle featuring a trinuclear zinc complex for direct air capture}, volume = {64}, year = {2025}, }
• (2025). Outside back cover: Conduction band and defect engineering for the prominent visible-light responsive photocatalysts. ANGEW, 64(13), e202505560. (www)

  @article{ , archive = {J_ANGEW}, author = {Akira Yamakata and Kosaku Kato and Takafumi Ogawa and Kanta Ogawa and Makoto Ogawa and Daichi Kato and Chengchao Zhong and Akihide Kuwabara and Ryu Abe and Hiroshi Kageyama}, doi = {10.1002/anie.202505560}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202505560}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Outside back cover: Conduction band and defect engineering for the prominent visible-light responsive photocatalysts}, volume = {64}, year = {2025}, }
• (2025). Inside front cover: General and versatile nanoarchitectonics for amino acid-based glasses via co-assembly of organic counterions. ANGEW, 64(13), e202504469. (www)

  @article{ , archive = {J_ANGEW}, author = {Xianbao Li and Yang Yang and Zhiqi Zhao and Shiwei Bai and Qi Li and Junbai Li}, doi = {10.1002/anie.202504469}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202504469}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside front cover: General and versatile nanoarchitectonics for amino acid-based glasses via co-assembly of organic counterions}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: An anionic mesoionic carbene (anMIC) and its transformation to metallo MIC-boranes: Synthesis and properties. ANGEW, 64(13), e202504464. (www)

  @article{ , archive = {J_ANGEW}, author = {Richard Rudolf and Andrej Todorovski and Vera Lederer and Nicolas I. Neuman and Hartmut Schubert and Biprajit Sarkar}, doi = {10.1002/anie.202504464}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202504464}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: An anionic mesoionic carbene (anMIC) and its transformation to metallo MIC-boranes: Synthesis and properties}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Control of interlocking mode in Pd4L8 cage catenanes (Angew. chem. int. ed. 13/2025). ANGEW, 64(13), e202504288. (www)

  @article{ , archive = {J_ANGEW}, author = {Pedro Montes-Tolentino and Alexander S. Mikherdov and Christoph Drechsler and Julian J. Holstein and Guido H. Clever}, doi = {10.1002/anie.202504288}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202504288}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Control of interlocking mode in Pd4L8 cage catenanes (Angew. chem. int. ed. 13/2025)}, volume = {64}, year = {2025}, }
• (2025). A general strategy for the synthesis of metal-backboned molecules with different metals. ANGEW, 64(13), e202502327. (www)

  @article{ , abstract = {Metal-backboned molecules have been recently explored as a new class of materials with remarkable physical and chemical properties. However, their backbones are mainly composed of Ni atoms and poses challenges in incorporating a wide range of metallic elemental species, which has severely hindered their further development. Herein, we have designed a general synthesis strategy and obtained new metal-backboned molecules with a variety of metals including Cu, Ru, Rh, Pd, Ag and Pt in the backbones through a ligand-assisted strategy under screening reaction conditions. The metal backbone with seven Cu atoms has been carefully demonstrated for the synthesis. The intriguing optical properties, electronic band gaps and thermal properties for the metal-backboned molecules have been further explored. This work provides a new avenue on the synthesis of high-performance metal-backboned molecule materials for promising applications in the future.}, archive = {J_ANGEW}, author = {Yanruzhen Wu and Yifeng Zhang and Kaiwen Zeng and Xiangran Cheng and Jiatian Song and Huisheng Peng}, doi = {10.1002/anie.202502327}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202502327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A general strategy for the synthesis of metal-backboned molecules with different metals}, volume = {64}, year = {2025}, }
• (2025). Soumitra maity. ANGEW, 64(13), e202502300. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202502300}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202502300}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Soumitra maity}, volume = {64}, year = {2025}, }
• (2025). Highly effective and durable integrated-chainmail electrode for h2 production through H2S electrolysis. ANGEW, 64(13), e202502032. (www)

  @article{ , abstract = {H 2 S is a prevalent yet toxic gas commonly encountered during fossil fuel extraction, whose electrolysis not only addresses pollution concerns but also facilitates hydrogen production. However, the advancement of H 2 S electrolysis at high current density has been impeded by the lack of stable and highly active electrodes that can endure the corrosive effects of H 2 S poisoning. Herein, we present an integrated-chainmail electrode that features dual-level chainmail structure with graphene encapsulating nickel foam (Ni@NC foam) to enhance H 2 S electrolysis. The electrode comprises a primary chainmail, formed by graphene coating on the surface of nickel foam, and a secondary chainmail, created by graphene encapsulating nickel nanoparticles. This integrated-chainmail structure significantly enhances both the activity and stability of nickel foam, which delivers an industrial-scale high current density exceeding 1 A cm −2 at 1.12 V versus reversible hydrogen electrode, above five times higher than nickel foam. Moreover, the Ni@NC foam remains stable over 300 hours of test, demonstrating a lifespan at least ten times longer than nickel foam. In a demo for H 2 S removal from simulated natural gas, the Ni@NC foam as the electrodes exhibits a hydrogen production rate of 272 ml min −1 , while reducing electricity consumption by 43 % compared with traditional water electrolysis.}, archive = {J_ANGEW}, author = {Mo Zhang and Zuochao Wang and Liumo Jiang and Xin Bo and Xiaoju Cui and Dehui Deng}, doi = {10.1002/anie.202502032}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202502032}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly effective and durable integrated-chainmail electrode for h2 production through H2S electrolysis}, volume = {64}, year = {2025}, }
• (2025). A mechanochromic rotaxane that releases azetidine-trityl-maleimide, a versatile fluorescent probe. ANGEW, 64(13), e202501499. (www)

  @article{ , abstract = {Force sensing at the molecular level has enabled the study of materials failure and it offers great promises for the investigation of mechanobiological processes. Traditional force probes rely on the reversible or irreversible activation of mechanochromic precursors to assess transient or permanent changes in polymer networks. A promising approach involves force-controlled release of sensing molecules, as the accumulation of chromic molecules at specific sites would enable the recording of deformation histories. However, many fluorescent probes are limited by environmental sensitivity, specific release conditions, or low release efficiency. Maleimide-based dyes, especially amino maleimides, offer a robust alternative due to their small size, structural versatility, and tuneable fluorescence properties. Here, we present a mechanochromic rotaxane device that releases an azetidine-trityl-maleimide (ATM) fluorescent probe via a retro-[4+2] cycloaddition reaction. ATM is a rigidochromic, chemically stable, and environmentally insensitive probe, generated exclusively through rotaxane actuation, underscoring the unique mechanochemical properties of rotaxanes. This device holds potential for applications in material science and biology, such as the investigation of polymer networks and active tissues.}, archive = {J_ANGEW}, author = {Mengjiao Wu and Guillaume De Bo}, doi = {10.1002/anie.202501499}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202501499}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A mechanochromic rotaxane that releases azetidine-trityl-maleimide, a versatile fluorescent probe}, volume = {64}, year = {2025}, }
• (2025). Afterglow Copper(I) iodine cluster scintillator. ANGEW, 64(13), e202500481. (www)

  @article{ , abstract = {Copper(I) iodine clusters have drawn intense attention due to their advantageous photophysical properties, such as a high luminescence efficiency, large Stokes shift, and tunable luminescence lifetimes. In this work, a copper(I) iodine cluster ( Cu 2 I 2 -CH 3 CN ) was synthesized, which exhibits unique afterglow emission, ultrahigh quantum yield (90.1 % in solid state) and aggregation-induced emission (AIE) behavior. It was found that thermally activated delayed fluorescence (TADF) and long-lifetime phosphorescence occur simultaneously in Cu 2 I 2 -CH 3 CN . The unique photoluminescence properties of Cu 2 I 2 -CH 3 CN were attributed to the large spin-orbit coupling (SOC) and long-term rigidity of the crystal. The high quantum efficiency, TADF characteristics, and heavy-atom composition of Cu 2 I 2 -CH 3 CN endow it with excellent X-ray excited luminescence (XEL) properties, making it a promising X-ray scintillator. A flexible scintillator screen made of Cu 2 I 2 -CH 3 CN was successfully fabricated and used for X-ray imaging with a spatial resolution of 23.6 LP mm −1 .}, archive = {J_ANGEW}, author = {Ying-Nan Zhao and Qi Yang and Bo-Han Yao and Ruo-Yu Cao and Han Zhang and Shi-Long Wei and Dong-Hui Wei and Kai Li and Yu-Bing Si and Shuang-Quan Zang}, doi = {10.1002/anie.202500481}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202500481}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Afterglow Copper(I) iodine cluster scintillator}, volume = {64}, year = {2025}, }
• (2025). An organic crystalline ternary pseudo-heterojunction with contrasting luminescent and mechanical properties prepared by thermotropic phase transition. ANGEW, 64(13), e202500151. (www)

  @article{ , abstract = {Advancements in crystal engineering have enabled the precise tuning of the physical properties of organic crystals, thereby enhancing their potential in advanced optoelectronics. Here, we design an organic compound which crystallizes into distinct polymorphs with contrasting luminescent and mechanical behaviors. Controlled growth conditions yield flexible (Cry- O : orange fluorescence) and brittle (Cry- Y : yellow fluorescence) crystals which exhibit unique fluorescence shifts and reversible spectral changes between room and low temperatures, alongside unidirectional phase transitions upon thermal stimulation. The optical and mechanical differences between the polymorphs O and Y stem from their distinct molecular packing arrangements and intermolecular interactions. Notably, Cry- O undergoes sequential phase transitions upon heating to 98 and 132 °C, enabling the creation of a ternary “pseudo-heterojunction” structure, facilitating the integration of multiple functional phases into a single material. These findings not only enhance the understanding of structure–property relationships of organic materials but also demonstrate the potential of polymorphism-driven property tuning for optoelectronic devices, thermal management systems, and optical sensors.}, archive = {J_ANGEW}, author = {Jianqun Qi and Linfeng Lan and Hongyu Zhang}, doi = {10.1002/anie.202500151}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202500151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An organic crystalline ternary pseudo-heterojunction with contrasting luminescent and mechanical properties prepared by thermotropic phase transition}, volume = {64}, year = {2025}, }
• (2025). G-C3N4 S-scheme homojunction through van der waals interface regulation by intrinsic polymerization tailoring for enhanced photocatalytic h2 evolution and CO2 reduction. ANGEW, 64(13), e202425439. (www)

  @article{ , abstract = {The effective S-scheme homojunction relies on the precise regulation of band structure and construction of advantaged charge migration interfaces. Here, the electronic structural properties of g-C 3 N 4 were modulated through meticulous polymerization of self-assembled supramolecular precursors. Experimental and DFT results indicate that both the intrinsic bandgap and surface electronic characteristics were adjusted, leading to the formation of an in-situ reconstructed homojunction interface facilitated by intrinsic van der Waals forces. The homojunction catalyst, composed of g-C 3 N 4 nanodots and ultra-thin g-C 3 N 4 nanoflakes, exhibited a significant S-scheme carrier separation mechanism, which enhances the utilization of electrons and holes. Consequently, under AM 1.5 light irradiation (~100 mW/cm 2 ), the g-C 3 N 4 homojunction photocatalyst achieved a remarkable hydrogen evolution rate of 580 μmol h −1 . Furthermore, a reversed CH 4 selectivity in CO 2 reduction was observed, yielding 80.30 μmol g −1 h −1 with a selectivity of 96.86 %, in contrast to the performance of bulk g-C 3 N 4 , which produced only 2.22 μmol g −1 h −1 with the 15.69 % CH 4 selectivity. These findings not only highlight the significant potential of the g-C 3 N 4 homojunction photocatalyst for hydrogen production and CO 2 reduction but also propose a superior and effective strategy for optimizing the structural properties of g-C 3 N 4 , which are crucial for the design of photocatalytic reactions.}, archive = {J_ANGEW}, author = {Xianglin Zhu and Enlong Zhou and Xishi Tai and Huibin Zong and Jianjian Yi and Zhimin Yuan and Xingling Zhao and Peng Huang and Hui Xu and Zaiyong Jiang}, doi = {10.1002/anie.202425439}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202425439}, shortjournal = {Angew. Chem. Int. Edit.}, title = {G-C3N4 S-scheme homojunction through van der waals interface regulation by intrinsic polymerization tailoring for enhanced photocatalytic h2 evolution and CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Vesicle-encapsulated chemosensing ensembles allow monitoring of transmembrane uptake coupled with enzymatic reactions. ANGEW, 64(13), e202425157. (www)

  @article{ , abstract = {Compartmentalized models with coupled catalytic networks are considered as “protocells” in the context of research related to the origin of life. To model the kinetics of a simple cellular uptake-metabolism process, we use a compartmentalized protocell system that combines liposome-encapsulated intravesicular reporter pairs with co-encapsulated enzymes to monitor the membrane transport of a substrate (analyte uptake) and its subsequent enzymatic reaction inside the vesicles (metabolism to the product). The intravesicular chemosensing ensembles consist of the macrocycles cucurbit[7]uril or p -sulfonatocalix[4]arene and matching fluorescent dyes to set up suitable reporter pairs. When these macrocycle/dye reporter pairs are co-encapsulated with enzymes (trypsin, protein kinase A, or butyrylcholinesterase), it is possible to monitor first the transport of different substrates (polylysine, protamine, H-LRRWSLG-OH, or butyrylcholine) through added pores (outer membrane proteins F and C), with synthetic carriers (amphiphilic calixarenes), or by direct permeation (only for butyrylcholine). The subsequent enzymatic conversions of the substrates after they have entered the corresponding protocells can be monitored as consecutive reactions. The new type of in vitro assays can be applied to different enzymes and analytes, affording a comprehensive chemosensing system of high chemical complexity.}, archive = {J_ANGEW}, author = {Ruixue Jiang and Mohamed Nilam and Claudio Piselli and Mathias Winterhalter and Dong-Sheng Guo and Sin-Yi Yu and Andreas Hennig and Werner M. Nau}, doi = {10.1002/anie.202425157}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202425157}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vesicle-encapsulated chemosensing ensembles allow monitoring of transmembrane uptake coupled with enzymatic reactions}, volume = {64}, year = {2025}, }
• (2025). Dynamic kinetic resolution allows control of remote stereochemistry in asymmetric hydrogen borrowing alkylation. ANGEW, 64(13), e202424959. (www)

  @article{ , abstract = {A catalytic asymmetric method for the synthesis of γ-substituted ketones via hydrogen borrowing alkylation of both racemic linear precursors and 1,5-diols is described. The base mediated racemization of an intermediate cyclohexenone to facilitates a dynamic kinetic resolution, affording highly enantioenriched cyclohexanes in excellent yields, which could be further functionalized by removal of the Ph* group. DFT modelling revealed the mode of enantioinduction to be a stepwise process comprising of a hydride transfer and a coordination change to a π-allylic enolate complex with the iridium catalyst.}, archive = {J_ANGEW}, author = {Daniella M. J. Cheang and Jessica L. Crompton and Mostafa M. Amer and Francisco Battiti and Bastian Bjerkem Skjelstad and Kirsten E. Christensen and Peter Barton and Fernanda Duarte and Timothy J. Donohoe}, doi = {10.1002/anie.202424959}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424959}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic kinetic resolution allows control of remote stereochemistry in asymmetric hydrogen borrowing alkylation}, volume = {64}, year = {2025}, }
• (2025). The first antimony borosulfates unveil a modular system MIIIMI[B(SO4)2]4 (MIII=Bi3+, sb3+, lu3+; MI=H3O+, NO2+, li+, na+, k+, rb+, cs+). ANGEW, 64(13), e202424952. (www)

  @article{ , abstract = {Recently we reported the synthesis and characterization of Bi(H 3 O)[B(SO 4 ) 2 ] 4 , at that time representing only the second tectosilicate analogous borosulfate. Inspired by this structure type, we herein present the first modular system within borosulfate chemistry. M III M I [B(SO 4 ) 2 ] 4 (M III =Bi 3+ , Sb 3+ , Lu 3+ ; M I =H 3 O + , NO 2 + , Li + , Na + , K + , Rb + , Cs + ) were synthesised under solvothermal conditions and show a large variability towards their mono- and trivalent cation while retaining the same three-dimensional anionic network. Based on their combination, the titled compounds crystallize in the tetragonal space groups I (no. 82), P (no. 81) and the monoclinic space group C 2 (no. 5) all connected via group-subgroup relations. Our initial characterization includes single-crystal as well as powder X-ray diffraction, vibrational spectroscopy and thermal analysis of the new compounds.}, archive = {J_ANGEW}, author = {Erich Turgunbajew and Henning A. Höppe}, doi = {10.1002/anie.202424952}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424952}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The first antimony borosulfates unveil a modular system MIIIMI[B(SO4)2]4 (MIII=Bi3+, sb3+, lu3+; MI=H3O+, NO2+, li+, na+, k+, rb+, cs+)}, volume = {64}, year = {2025}, }
• (2025). Aryl silicon nucleophiles in bismuth catalysis. ANGEW, 64(13), e202424698. (www)

  @article{ , abstract = {We present a catalytic protocol utilizing bismuth for the synthesis of aromatic fluorinated thiosulfones, showcasing a seminal example of aryl silicon nucleophiles in Bi catalysis. This catalytic process is enabled by a series of Bi-based organometallic transformations, including an unprecedented transmetalation of aryl silicates to Bi(III) complexes and the formal migratory insertion of sulfur dioxide (SO 2 ) into the Bi-C bond. The protocol is compatible with a wide range of anionic and neutral Ar-Si compounds, including heterocycles. Stoichiometric investigations of individual organometallic steps provide strong evidence supporting a Bi-redox-neutral catalytic cycle.}, archive = {J_ANGEW}, author = {Teresa Faber and Sophia Engelhardt and Josep Cornella}, doi = {10.1002/anie.202424698}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aryl silicon nucleophiles in bismuth catalysis}, volume = {64}, year = {2025}, }
• (2025). Regulation of TADF by internal and external heavy atom effect in D-A MOF for heterocrystal based temperature-compensated photonic device. ANGEW, 64(13), e202424593. (www)

  @article{ , abstract = {The application of temperature-compensated photonic device is hampered by poor accuracy and overly simplistic functions of propagation in photonic integrated circuits (PICs) field. Herein, we report a new library of donor-acceptor metal–organic framework (D−A MOF) with thermally activated delayed fluorescence (TADF) and the fabricating of temperature-compensated photonic device by virtue of the unique temperature response character of TADF emitters. Highly tunable through-space charge transfer (TSCT) of TADF was realized within the D−A MOFs through a novel strategy that synergistically combines the internal heavy atom effect (HAE) with an external HAE, induced by the incorporation of heavy atoms into different components, achieving the regulable photophysical indicators including adjustable PL wavelength (534 to 592 nm) and surging quantum yield (5.02 %–47.39 %). Further investigation of the impact of external HAE on TADF was conducted through crystal structures and Hirshfeld surface plots of four D−A regimes featuring substituent-based linkers. Notably, temperature-compensated photonic device based on heterocrystal was fabricated through integrating D−A MOFs with contrary temperature response. The emission signal output of the heterojunction remained nearly stable in 215 K to 295 K range, highlighting the promising potential application of TADF D−A MOF featuring sensitive temperature response in PICs field.}, archive = {J_ANGEW}, author = {Bo Zhang and Chang-Tai Li and Han-Yu Wang and Han Fang and Rui Feng and Mei-Hui Yu and Wei Li and Ze Chang and Xian-He Bu}, doi = {10.1002/anie.202424593}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulation of TADF by internal and external heavy atom effect in D-A MOF for heterocrystal based temperature-compensated photonic device}, volume = {64}, year = {2025}, }
• (2025). La3+ doped nickel-manganese oxide as high-capacity cathode for sodium-ion batteries guided by bayesian optimization. ANGEW, 64(13), e202424572. (www)

  @article{ , abstract = {In sodium-ion batteries, the layered transition metal oxides used as cathode often experience interlayer sliding of interlayer spacing and lattice variations during charge/discharge, leading to structural damage and capacity degradation. To address this challenge, a La 3+ doping strategy guided by Bayesian optimization has been employed to prepare the high-performance O3-NaNi 0.39 Mn 0.50 Cu 0.06 La 0.05 O 2 (NMCL) cathode material. Density functional theory calculations reveal that the O 2p orbital overlaps with the t 2g orbital of transition metals in NMCL, facilitating the formation of Na−O−La bonds and promoting the oxygen redox reaction kinetics. During the Na + (de)intercalation process, NMCL exhibits significant negative lattice expansion, characterized by an increase in the c lattice parameter and exceptionally low volume expansion of 1.8 % and 3.1 %, respectively. Consequently, it delivers an excellent specific capacity of 243.3 mAh g −1 over a wide voltage range of 2.0 V to 4.5 V, which can be attributed to La 3+ doping that promotes oxidation of O 2− to peroxide O 2 n− ( n <2) during charge.}, archive = {J_ANGEW}, author = {Jie Feng and Dapeng Liu and Jin Sun and Xiangrui Gong and Tingting You and Ying Jiang and Yu Zhang}, doi = {10.1002/anie.202424572}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {La3+ doped nickel-manganese oxide as high-capacity cathode for sodium-ion batteries guided by bayesian optimization}, volume = {64}, year = {2025}, }
• (2025). Nickel nanocluster-stabilized unsaturated Ni–N3 atomic sites for efficient CO2-to-CO electrolysis at industrial-level current. ANGEW, 64(13), e202424552. (www)

  @article{ , abstract = {Unsaturated Ni single-atom catalysts (SACs), Ni-N x ( x =1,2,3), have been investigated to break the conventional Ni-N 4 structural limitation and provide more unoccupied 3d orbitals for CO 2 reduction reaction (CO 2 RR) intermediates adsorption, but their intrinsically low structural stability has seriously hindered their applications. Here, we developed a strategy by integrating Ni nanoclusters to stabilize unsaturated Ni-N 3 atomic sites for efficient CO 2 electroreduction to CO at industrial-level current. Density Functional Theory (DFT) calculations revealed that the incorporation of Ni nanocluster effectively stabilizes the unsaturated Ni-N 3 atomic sites and modulates their electronic structure to enhance the adsorption of the key intermediate *COOH during CO 2 RR. Guided by these insights, we prepared an optimal composite catalyst, Ni 6 @Ni-N 3 , which features a Ni 6 N 6 nanocluster surrounded by six Ni-N 3 single atoms sites, through low-temperature pyrolysis. The morphology and coordinative structure of Ni 6 @Ni-N 3 were confirmed by an aberration-corrected transmission electron microscope (AC-TEM) and X-ray absorption spectroscopy (XAS). As a result, Ni 6 @Ni-N 3 demonstrated a remarkably high CO Faradaic efficiency (FE CO ) of 99.7 % and a turnover frequency (TOF) of 83984.2 h −1 at 500 mA cm −2 under −1.15 V RHE , much better than those of Ni-N 4 with a lower FE CO of 86 % at 100 mA cm −2 and a TOF of 39309.9 h −1 under identical potential. XAS analyses of Ni 6 @Ni-N 3 before and after long-term CO 2 RR testing confirmed the excellent stability of its coordinative environment. This work highlights a generalizable approach for stabilizing unsaturated single-atom catalysts, paving the way for their application in high-performance CO 2 RR.}, archive = {J_ANGEW}, author = {Wuyi Zhang and Asad Mehmood and Ghulam Ali and Hui Liu and Liyuan Chai and Jun Wu and Min Liu}, doi = {10.1002/anie.202424552}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424552}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel nanocluster-stabilized unsaturated Ni–N3 atomic sites for efficient CO2-to-CO electrolysis at industrial-level current}, volume = {64}, year = {2025}, }
• (2025). Covalent organic frameworks with carbon-centered radical sites for promoting the 4e− oxygen reduction reaction. ANGEW, 64(13), e202424449. (www)

  @article{ , abstract = {Radical covalent organic frameworks (RCOFs) have demonstrated significant potential in redox catalysis and energy conversion applications. However, the synthesis of stable RCOFs with well-defined neutral carbon radical centers is challenging due to the inherent radical instability, limited synthetic methods and characterization difficulties. Building upon the understanding of stable carbon radicals and structural modulations for preparing crystalline COFs, herein we report the synthesis of a crystalline carbon-centered RCOF through a facile post-oxidation process. Moreover, the RCOF demonstrated outstanding catalytic activity in the 4e − oxygen reduction reaction (ORR) with a half-wave potential of 0.82 V (vs. RHE) and electron transfer number of 3.98, among the highest in reported COF-based electrocatalysts. The promoted 4e − and suppressed 2e − ORR pathway (99.5 % vs. 0.5 %) can be attributed to facilitated reaction initiation and smoother transition steps at the carbon radical sites, which is practically beneficial for minimizing peroxide formation, thus contributing to safer and more sustainable fuel cell and metal-air battery applications. Overall, our study not only provided a facile strategy for preparing stable RCOFs with well-defined neutral carbon radical centers but also demonstrated their capability to fine-tune the redox catalytic activity of COF materials, which could be potentially useful in electrocatalysis and energy conversion applications.}, archive = {J_ANGEW}, author = {Tingting Xu and Huaqun Zhou and Xiaofei Zhang and Tun Seng Herng and Jun Ding and Chunyan Chi and Jun Zhu}, doi = {10.1002/anie.202424449}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424449}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent organic frameworks with carbon-centered radical sites for promoting the 4e− oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Engineering lattice dislocations of TiO2 support of PdZn−ZnO dual-site catalysts to boost CO2 hydrogenation to methanol. ANGEW, 64(13), e202424435. (www)

  @article{ , abstract = {CO 2 hydrogenation to methanol using green hydrogen derived from renewable resources provides a promising method for sustainable carbon cycle but suffers from high selectivity towards byproduct CO. Here, we develop an efficient PdZn−ZnO/TiO 2 catalyst by engineering lattice dislocation structures of TiO 2 support. We discover that this modification orders irregularly arranged atoms in TiO 2 to stabilize crystal lattice, and consequently weakens electronic interactions with supported active phases. It facilitates the transformation of metallic Pd into PdZn alloy, effectively suppressing CO production through inhibiting the reverse water-gas shift reaction mediated by the carboxylate pathway on Pd 0 sites. Moreover, it enables the efficient transfer of hydrogen species via hydrogen spillover from PdZn alloy to ZnO for compensating the poor hydrogen dissociation ability of ZnO, thereby creating both more oxygen vacancies essential for CO 2 activation and a hydroxyl-rich environment conducive to hydrogenation of intermediates. These collective modifications on PdZn−ZnO dual sites synergistically induce the propensity of the formate pathway for methanol synthesis. Consequently, compared to the unmodified catalyst, our as-designed catalyst increases methanol selectivity from 64.2 to 80.0 %, reduces CO selectivity from 35.0 to 19.8 %, and achieves an impressive methanol space-time yield of 9028.0 mg MeOH g Pd+Zn −1 h −1 at a similar CO 2 conversion (~8.0 %).}, archive = {J_ANGEW}, author = {Xiaoshen Li and Qingpeng Cheng and Yingtian Zhang and Yunhao Liu and Yu Pan and Dejian Zhao and Shaohui Xiong and Wei Liu and Xueyang Jiang and Jiayan Yan and Xiang Duan and Ye Tian and Xingang Li}, doi = {10.1002/anie.202424435}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424435}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering lattice dislocations of TiO2 support of PdZn−ZnO dual-site catalysts to boost CO2 hydrogenation to methanol}, volume = {64}, year = {2025}, }
• (2025). Cobalt-catalyzed enantioselective reductive coupling of imines and internal alkynes. ANGEW, 64(13), e202424394. (www)

  @article{ , abstract = {Chiral allylamines are important structural components in natural products, pharmaceuticals, and chiral catalysts. Herein, we report a cobalt-catalyzed enantioselective reductive coupling of imines with internal alkynes to synthesize chiral allylamines. The reaction is catalyzed by a cobalt complex derived from commercially available bisphosphine ligand utilizing zinc as the electron donor. The substrate scope is extensive. Symmetric and unsymmetric alkyl and aryl alkynes have been successfully coupled with various imines derived from aryl and alkyl aldehydes. Tri- and tetra-substituted allyl amines were isolated in high yields, with enantiomeric excess surpassing >99.9 % and regioselectivities exceeding >20 : 1. These chiral allyl amines can serve as versatile platforms for subsequent transformations while preserving their stereochemical integrity. Extensive experimental and computational mechanistic studies were performed to elucidate the mechanism. These investigations have indicated that an in situ cobalt(I) catalyst enables the oxidative cyclization of alkynes and imines, and a spin crossover occurs during the enantio-determining step. Zinc plays a pivotal role in facilitating the transmetallation of the resulting azacobaltacycle. The observed enantioselectivity was interpreted by the stabilization of the transition state through higher stabilizing interaction energy from high negative polarization, dispersion, and C−H⋅⋅⋅π interactions.}, archive = {J_ANGEW}, author = {Kakoli Maji and Angshuman Palai and Dibyendu Mallick and Biplab Maji}, doi = {10.1002/anie.202424394}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424394}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-catalyzed enantioselective reductive coupling of imines and internal alkynes}, volume = {64}, year = {2025}, }
• (2025). Electrolyte chemistry towards ultra-high voltage (4.7 v) and ultra-wide temperature (−30 to 70 °C) LiCoO2 batteries. ANGEW, 64(13), e202424353. (www)

  @article{ , abstract = {LiCoO 2 batteries for 3 C electronics demand high charging voltage and wide operating temperature range, which are virtually impossible for existing electrolytes due to aggravated interfacial parasitic reactions and sluggish kinetics. Herein, we report an electrolyte design strategy based on a partially fluorinated ester solvent (i.e., DFEA) that achieves a balance between weak Li + -solvent interactions, sufficient salt dissociation, high interfacial stability, and superior thermal stability to address the aforementioned challenges. The resulting high-voltage wide-temperature electrolyte (HWE) not only possesses low desolvation energy, fast Li + transport, high oxidation stability, excellent thermal-abuse tolerance and non-flammability, but also enables the formation of both inorganic-rich cathode electrolyte interphase (CEI) and solid electrolyte interphase (SEI). Owing to the above merits, this HWE endows the highly stable operation of LiCoO 2 cathodes under an ultra-high voltage of 4.7 V and Graphite || LiCoO 2 batteries in an ultra-wide temperature range of −30 to 70 °C. Meanwhile, a 1.7 Ah-level 4.6 V Graphite || LiCoO 2 pouch cell with a high energy density of 240 Wh kg −1 also delivers excellent cycling stability, representing a significant advancement in the design of electrolytes towards ultra-high voltage and ultra-wide temperature batteries.}, archive = {J_ANGEW}, author = {Wenming Yang and Wen Chen and Hanqing Zou and Jiawei Lai and Xueyi Zeng and Yuping Zhang and Xing Zeng and Kui Ding and Shiwei Zhang and Liang Ma and Zhongliang Li and Qifeng Zheng}, doi = {10.1002/anie.202424353}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte chemistry towards ultra-high voltage (4.7 v) and ultra-wide temperature (−30 to 70 °C) LiCoO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Interfacial oxygen vacancy-copper pair sites on inverse CeO2/Cu catalyst enable efficient CO2 electroreduction to ethanol in acid. ANGEW, 64(13), e202424248. (www)

  @article{ , abstract = {Renewable electricity-driven electrochemical reduction of CO 2 offers a promising route for the production of high-value ethanol. However, the current state of this technology is hindered by low selectivity and productivity, primarily due to a limited understanding of the atomic-level active sites involved in ethanol formation. Herein, we identify that the interfacial oxygen vacancy-neighboring Cu (O v -Cu) pair sites are the active sites for CO 2 electroreduction to ethanol. A linear correlation between the density of O v -Cu pair sites and ethanol productivity is experimentally evidenced. Moreover, a high Faradaic efficiency of 48.5 % and a partial current density of 344.0 mA cm −2 for ethanol production are achieved over the inverse CeO 2 /Cu catalyst with a high density of O v -Cu pair sites in acid. Mechanistic studies that combine density functional theory calculations and spectroscopic techniques propose an O v -involved mechanism where interfacial O v sites directly activate and dissociate CO 2 into *CO in a thermodynamically spontaneous manner, thus favoring the subsequent *CHO formation and asymmetric CHO-CO coupling. Besides, the asymmetric O v -Cu pair sites could preferentially stabilize the *CH 2 CHOH intermediate, resulting in the favorable formation of ethanol over ethylene. Our findings provide new atomic-level insights into CO 2 electroreduction to ethanol, paving the way for the rational design of future catalysts.}, archive = {J_ANGEW}, author = {Yan Qiao and Shenyu Shen and Chenghui Mao and Yongchun Xiao and Wenchuan Lai and Yanan Wang and Xingyu Zhong and Yangfan Lu and Jiong Li and Jingjie Ge and Hsien-Yi Hsu and Yaqiong Su and Minhua Shao and Zheng Hu and Hongwen Huang}, doi = {10.1002/anie.202424248}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424248}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial oxygen vacancy-copper pair sites on inverse CeO2/Cu catalyst enable efficient CO2 electroreduction to ethanol in acid}, volume = {64}, year = {2025}, }
• (2025). Asymmetric gem-hydroboration and gem-hydrogenation of ynamides: A new gateway to chiral fischer carbene complexes and their catalytic transformations. ANGEW, 64(13), e202424212. (www)

  @article{ , abstract = {Ynamides, when reacted with H 2 or HBpin in the presence of [Cp*RuCl] 4 , convert into chiral-at-metal Fischer carbenes by regioselective gem -hydrogenation or gem -hydroboration of the polarized triple bond, respectively. gem -Hydroboration concomitantly affords a carbogenic borylated stereocenter adjacent to the ruthenium carbene unit, the configuration of which can be controlled using an Evans auxiliary. These are the first examples of asymmetric gem -addition reactions to alkynes known in the literature; representative pianostool ruthenium carbene complexes formed by this unconventional route were characterized by crystallographic and spectroscopic means. They undergo various stoichiometric reactions and can even entertain catalytic asymmetric transformations, such as hydrogenative cyclopropanations or a novel type of borylative cycloisomerization.}, archive = {J_ANGEW}, author = {Juan Carlos Babón Molina and Luis Renken and Markus Leutzsch and Ricardo Molina Betancourt and Alois Fürstner}, doi = {10.1002/anie.202424212}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424212}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric gem-hydroboration and gem-hydrogenation of ynamides: A new gateway to chiral fischer carbene complexes and their catalytic transformations}, volume = {64}, year = {2025}, }
• (2025). Functionalization of pyridines at the c4 position via metalation and capture. ANGEW, 64(13), e202424172. (www)

  @article{ , abstract = {The functionalization of pyridines at positions remote to the N-atom remains an outstanding problem in organic synthesis. The inherent challenges associated with overriding the influence of the embedded N-atom within pyridines was overcome using n- butylsodium, which provided an avenue to deprotonate and functionalize the C4-position over traditionally observed addition products that are formed with organolithium bases. In this work, we show that freshly generated 4-sodiopyrdines could undergo transition metal free alkylation reactions directly with a variety of primary alkyl halides bearing diverse functional groups. In addition, after transmetalation to zinc chloride a simple and efficient Negishi cross-coupling protocol was formulated for a variety of aromatic and heteroaromatic halides. The robustness of this protocol was demonstrated through the late-stage installation of 4-pyridyl fragments into a variety of complex active pharmaceutical ingredients including loratadine and prochlorperazine. Furthermore, through rapid injection NMR investigations, we are able to directly observe the evolution of anionic intermediates and determined that two distinct mechanistic pathways lead to the observed site selectivity: (1) the C4-H within 2,6-disubstituted pyridines could be removed directly and (2) the C4 selectivity of unsubstituted pyridine originates from the intermolecular exchange of metalation sites via a thermodynamic pathway.}, archive = {J_ANGEW}, author = {Han-Hsiang Hsu and Seokmin Kang and Cheng-Chun Chen and Md Raja Sk and Andy A. Thomas}, doi = {10.1002/anie.202424172}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424172}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functionalization of pyridines at the c4 position via metalation and capture}, volume = {64}, year = {2025}, }
• (2025). Symmetry breaking of FeN4 moiety via edge defects for acidic oxygen reduction reaction. ANGEW, 64(13), e202424135. (www)

  @article{ , abstract = {Fe−N−C catalysts, with a planar D 4h symmetric FeN 4 structure, show promising as noble metal-free oxygen reduction reaction catalysts. Nonetheless, the highly symmetric structure restricts the effective manipulation of its geometric and electronic structures, impeding further enhancements in oxygen reduction reaction performance. Here, a high proportion of asymmetric edge-carbon was successfully introduced into Fe−N−C catalysts through morphology engineering, enabling the precise modulation of the FeN 4 active site. Electrochemical experimental results demonstrate that FeN 4 @porous carbon (FeN 4 @PC), featuring enriched asymmetric edge-FeN 4 active sites, exhibits higher acidic oxygen reduction reaction catalytic activity compared to FeN 4 @flaky carbon (FeN 4 @FC), where symmetric FeN 4 is primarily distributed within the basal-plane. Synchrotron X-ray absorption spectra, X-ray emission spectra, and theoretical calculations indicate that the enhanced oxygen reduction reaction catalytic activity of FeN 4 @PC is attributed to the higher oxidation state of Fe species in the edge structure of FeN 4 @PC. This finding paves the way for controlling the local geometric and electronic structures of single-atom active sites, leading to the development of novel and efficient Fe−N−C catalysts.}, archive = {J_ANGEW}, author = {Bing Tang and Qianqian Ji and Xilin Zhang and Runchuan Shi and Jin Ma and Zechao Zhuang and Mei Sun and Huijuan Wang and Ruiqi Liu and Hengjie Liu and Chao Wang and Zhiying Guo and Lanlu Lu and Peng Jiang and Dingsheng Wang and Wensheng Yan}, doi = {10.1002/anie.202424135}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424135}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Symmetry breaking of FeN4 moiety via edge defects for acidic oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Cationic magnetically active nitrogen-doped polycyclic aromatic hydrocarbon with record low band gap. ANGEW, 64(13), e202424128. (www)

  @article{ , abstract = {Polycyclic aromatic hydrocarbons (PAHs) have attracted significant interest in material chemistry, particularly if they own extremely low band gaps and magnetic properties. However, challenges remain regarding the synthetic accessibility and energy saturation issues. In this study, we introduce NR-11 , which consists of eleven aromatic rings in its main conjugation and is separately doped with two electron-rich nitrogen atoms. This unique structure imparts intriguing oxidation characteristics to NR-11 . The cationic radical NR-11 + ⋅ exhibits enhanced stability and demonstrates strong absorption in the range of 1250 nm to 3000 nm, peaking at 2570 nm. As a result, the optical energy gap of NR-11 + ⋅ is one of the lowest reported to date. Additionally, X-ray crystal structure analysis reveals that NR-11 + ⋅ displays unusual symmetry-broken charge separation. For the dication, variable-temperature NMR and variable-temperature EPR studies indicate that NR-11 2+ exhibits a high diradical character with a ▵E S-T of approximately −1 kcal/mol. Additionally, its spins are polarized at two ends of the PAH. Meanwhile, its strong absorption in the near-infrared II region suggests promise in photoacoustic (PA) conversion applications. This work underscores the significance of cationic species of extended long PAHs, highlighting their exceptional properties and potential applications.}, archive = {J_ANGEW}, author = {Yanxia Huang and Laiyun Zhou and Ruiying Zhang and Yeda Ding and Dan Shi and Lingyun Zhu and Lisen Lin and Yuanming Li and Qing Wang}, doi = {10.1002/anie.202424128}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424128}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cationic magnetically active nitrogen-doped polycyclic aromatic hydrocarbon with record low band gap}, volume = {64}, year = {2025}, }
• (2025). Tuning atomically dispersed metal sites in nanozymes for sensing applications. ANGEW, 64(13), e202424070. (www)

  @article{ , abstract = {Nanozymes with atomically dispersed metal sites (ADzymes), especially single-atom nanozymes, have attracted widespread attention in recent years due to their unique advantages in mimicking the active sites of natural enzymes. These nanozymes not only maximize exposure of catalytic sites but also possess superior catalytic activity performance, achieving challenging catalytic reactions. These advantages position ADzymes as highly promising candidates in the field of sensing and biosensing. This review summarizes the classification and properties of ADzymes, systematically highlighting some typical regulation strategies involving central metal, coordination environment, etc., to achieve their catalytical activity, specificity, and multifunctionality. Then, we present the recent advances of ADzymes in different sensing fields, including colorimetry, fluorescence, electrochemistry, chemiluminescence, photoelectrochemistry, and electrochemiluminescence. Taking advantage of their unique catalytic performance, the resultant ADzymes show great potential in achieving the goal of sensitivity, selectivity and accuracy for the detection of various targets. Specifically, the underlying mechanisms in terms of signal amplification were discussed in detail. Finally, the current challenges and perspectives on the development of advanced ADzymes are discussed.}, archive = {J_ANGEW}, author = {Mingwang Liu and Weiqing Xu and Yinjun Tang and Yu Wu and Wenling Gu and Dan Du and Yuehe Lin and Chengzhou Zhu}, doi = {10.1002/anie.202424070}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202424070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning atomically dispersed metal sites in nanozymes for sensing applications}, volume = {64}, year = {2025}, }
• (2025). Catalytic asymmetric total synthesis of (+)-chamaecydin and (+)-isochamaecydin and their stereoisomers. ANGEW, 64(13), e202423944. (www)

  @article{ , abstract = {A modular approach was developed for the first catalytic asymmetric total syntheses of naturally occurring C 30 terpene quinone methides and their non-natural stereoisomers, which feature the presence of an unprecedented spiro[4.4]nonane-containing 6–6–6-5–5–3 hexacyclic skeleton. Resting on a chiral phosphinamide-catalyzed enantioselective reduction of 2,2-disubstituted cyclohexane-1,3-dione, a concise route for the synthesis of enantioenriched 6–6 bicyclic fragment was developed. The 6–6 ring fragment and the five-membered ring fragment were unified via a metal-halogen exchange/intermolecular addition reaction. Subsequently, the central 6–5 bicyclic ring system was constructed through a Michael/aldol cascade. The successful establishment of these strategic transformations allowed for an efficient and rapid construction of spiroannulated 6–6–6–5–5 pentacarbocyclic core via a convergent manner. Finally, the total syntheses of naturally occurring (+)-chamaecydin and (+)-isochamaecydin and their corresponding 1’,5’-stereoisomers have been achieved divergently by appropriately orchestrating the reaction sequence including isopropyl incorporation, oxidation state adjustment, and carbonyl group-directed regio- and stereoselective cyclopropanation at a late stage.}, archive = {J_ANGEW}, author = {Yuan-He Zhang and Le-Hua Deng and Dong-Xing Tan and Fu-She Han}, doi = {10.1002/anie.202423944}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423944}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic asymmetric total synthesis of (+)-chamaecydin and (+)-isochamaecydin and their stereoisomers}, volume = {64}, year = {2025}, }
• (2025). From guest-induced crystallization to molecular imprinting: Calculation-guided discovery of hydrogen-bonded tetrazole frameworks for p-xylene separation. ANGEW, 64(13), e202423932. (www)

  @article{ , abstract = {Exploring host–guest interactions to regulate hydrogen-bonding assembly offers a promising approach for developing advanced porous crystal materials (PCMs). However, screening compatible guests with appropriate geometries and host–guest interactions that could inhibit the dense packing of building blocks remains a primary challenge. This study presents a novel guest-induced crystallization (GIC) strategy, guided by thermodynamic calculations, to develop porous hydrogen-bonded organic frameworks (HOFs) using structurally challenging tetrazole building units. Thermodynamic principles are established from the crystal structure data and the density functional theory calculation of the formation energy ( ΔE ). This provides criteria to identify available guests in GIC, enabling the successful discovery of a hidden HOF that is kinetically challenging to crystallize. Furthermore, the potential application for p -xylene (PX) separation is predicted by analyzing the ΔE of guest-induced HOFs. A high PX selectivity (PX/ m -xylene=6.1, PX/ o -xylene=7.2, and PX/ethylbenzene=4.1) is achieved through selective inclusion of PX from C8 aromatic isomers within the guest-induced HOFs. Significantly, the guest-free HOF ( HOF-PX-a ), bearing PX-templated cavities derived from molecular imprinting, shows a record-high PX/ethylbenzene selectivity (21.7) in liquid adsorption. This work elucidates the underpinning self-assembly rules of GIC for HOF construction, providing exciting new opportunities for the predictable assembly of PCMs for molecular recognition and target-specific separations.}, archive = {J_ANGEW}, author = {Yi Su and Qiang Gao and Xiaojun Ding and Gang Ye}, doi = {10.1002/anie.202423932}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From guest-induced crystallization to molecular imprinting: Calculation-guided discovery of hydrogen-bonded tetrazole frameworks for p-xylene separation}, volume = {64}, year = {2025}, }
• (2025). Orderly arranged cubic quantum dots along supramolecular templates of naphthalenediimide aggregates. ANGEW, 64(13), e202423912. (www)

  @article{ , abstract = {Precise control of assembled structures of quantum dots (QDs) is crucial for realizing the desired photophysical properties, but this remains challenging. Especially, the one-dimensional (1D) control is rare due to the nearly isotropic nature of QDs. Herein, we propose a novel strategy for controlling the 1D-arrangement range of cubic perovskite QDs in solution based on the morphological modification of a supramolecular polymer (SP) template. The original template with a short and tangled fibrous structure is prepared in a low-polarity solvent mixture via self-assembly of a naphthalenediimide-functionalized cholesterol derivative with an adhesion group for QDs. Mixing this template with QDs leads to the co-aggregation into short-range 1D-arrays of QDs on the templates. Notably, subsequent heating and cooling of the co-aggregate solution forms longer-range 1D-arrays of QDs with lateral growth, where arranged QDs are sandwiched between reconstructed SP templates. Furthermore, the longer-range 1D-array of QDs is achieved via an alternative route involving the pre-organization of templates into longer and dispersed fibers by heating and cooling of the original template, succeeded by co-assembly with QDs. Finally, we reveal continuous fluorescence resonance energy transfer between 1D-arranged QDs by an in-depth analysis of the photoluminescence decay curves.}, archive = {J_ANGEW}, author = {Amrutha Manoj Lena and Mitsuaki Yamauchi and Hideyuki Murakami and Naoki Kubo and Sadahiro Masuo and Kyohei Matsuo and Hironobu Hayashi and Naoki Aratani and Hiroko Yamada}, doi = {10.1002/anie.202423912}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423912}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orderly arranged cubic quantum dots along supramolecular templates of naphthalenediimide aggregates}, volume = {64}, year = {2025}, }
• (2025). Nitrogen-bridged S−N−Cu sites for CO2 photoreduction to ethanol with 99.5 % selectivity in pure water. ANGEW, 64(13), e202423859. (www)

  @article{ , abstract = {Solar-driven CO 2 reduction to ethanol is extremely challenging due to the limited efficiency of charge separation, sluggish kinetics of C−C coupling, and unfavorable formation of oxygenate intermediates. Here, we elaborately design a red polymer carbon nitride (RPCN) consisting of S−N and Cu−N 4 dual active sites (Cu/S-RPCN) to address this challenge, which achieves an impressive ethanol evolution rate of 50.4 μmol g −1 h −1 with 99.5 % selectivity for CO 2 photoreduction in pure water. Cu and S atoms within the Cu−N−S configuration can serve as trapping centers for electrons and holes, respectively, providing spatial separation for photogenerated charge carriers. The incorporation of S atoms optimizes the adsorption of *CO on Cu atoms and reduces the energy barrier for the formation of *CO−COH intermediate. The adsorption strength of *OCHCH 2 OH intermediate on the Cu atoms via the O−Cu−C configuration can affect the selectivity of the C 2 products as the cleavage of the Cu−O/Cu−C bonds determines the ethanol/ethylene pathway. The S−N−Cu structure weakens the Cu−O bond, thereby promoting the production of ethanol. This work provides a novel approach to fine-tune the surrounding microenvironment of metal atoms on carbon nitride for highly effective photocatalytic conversion of CO 2 to ethanol.}, archive = {J_ANGEW}, author = {Weilin Li and Zheyang Liu and Baker Rhimi and Min Zhou and Jing Li and Kaiqi Nie and Binhang Yan and Zhifeng Jiang and Weidong Shi and Yujie Xiong}, doi = {10.1002/anie.202423859}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423859}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitrogen-bridged S−N−Cu sites for CO2 photoreduction to ethanol with 99.5 % selectivity in pure water}, volume = {64}, year = {2025}, }
• (2025). Reinforcing coverage of self-assembled monomolecular layers for inverted perovskite solar cells with efficiency of 25.70 %. ANGEW, 64(13), e202423827. (www)

  @article{ , abstract = {Self-assembled monolayers (SAM) as hole transport layers have been widely used in high-efficiency inverted perovskite solar cells (PSCs) exceeded 26 %. However, the poor coverage and non-uniform distribution on the substrate of SAM further restrict the improvement of device performance. Herein, we utilize the mixed SAM strategy via the MeO-2PACz along with perfluorotripropylamine (FC-3283) to improve the SAM coverage, aiming to accelerate the carrier transport, promote the perovskite growth, regulate the surface energy levels and suppress the nonradiative recombination. The champion device with the mixed-SAM achieves an efficiency of 25.70 % (certified efficiency of 25.6 %) with long-term stability (maintained the initial efficiency of 90 % after 1000 h and 180 h under ISOS-L-1 and ISOS-L-2).}, archive = {J_ANGEW}, author = {Xiwen Zhang and Yang Wang and Kun Zhang and Mingquan Tao and Haodan Guo and Lutong Guo and Zhaofei Song and Jinxu Wen and Yongrui Yang and Yuqing Hou and Yanlin Song}, doi = {10.1002/anie.202423827}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423827}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reinforcing coverage of self-assembled monomolecular layers for inverted perovskite solar cells with efficiency of 25.70 %}, volume = {64}, year = {2025}, }
• (2025). Solution-processed blue narrowband OLED devices with external quantum efficiency beyond 35 % through horizontal dipole orientation induced by electrostatic interaction. ANGEW, 64(13), e202423812. (www)

  @article{ , abstract = {The multiple resonance thermally activated delayed fluorescence (MR-TADF) device has drawn great attention due to their outstanding efficiency and color purity. However, the efficiency of solution-processed MR-TADF devices is still far behind their vacuum-deposited counterparts, due to the uncontrollable horizontal emitting dipole orientation for emitters during solution process, resulting in low light out-coupling efficiency. Here, we proposed a new strategy namely electrostatic interaction between a dendritic host with high positive electrostatic potential (ESP) and dendritic emitter with multiple negative ESP sites, which could induce high horizontal dipole ratio (Θ || ) up to 83.0 % in solution-processed films. For this couple, the largest plane of dendritic host tends to anchor on the substrate, and thus the strong positive electrostatic site mainly lies at the exposed tetraphenylsilicon, which could electrostatically attract the multiple negative electrostatic sites of the dendritic emitter, realizing horizontal dipole orientation. Moreover, the highly twisted structure of dendritic host and dendron encapsulation of emitter could effectively suppress aggregation, leading a high photoluminescence quantum yield of 98.6 %. As a result, the solution-processed blue MR-TADF devices exhibit a record-break external quantum efficiency of 35.3 %, as well as narrow bandwidth of 17 nm and pure blue color with CIE coordinates of (0.137, 0.176).}, archive = {J_ANGEW}, author = {Kaiyuan Zhang and Xingdong Wang and Mengyu Wang and Shumeng Wang and Lixiang Wang}, doi = {10.1002/anie.202423812}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423812}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solution-processed blue narrowband OLED devices with external quantum efficiency beyond 35 % through horizontal dipole orientation induced by electrostatic interaction}, volume = {64}, year = {2025}, }
• (2025). Control of interlocking mode in Pd4L8 cage catenanes. ANGEW, 64(13), e202423810. (www)

  @article{ , abstract = {Precise control over the catenation process in interlocked supramolecular systems remains a significant challenge. Here, we report a system in which a lantern-shaped Pd 2 L 4 cage can dimerize to form two distinct Pd 4 L 8 catenanes with different interlocking degree: a previously described quadruply interlocked double cage motif of D 4 symmetry and an unprecedented triply interlocked structure of C 2h symmetry. While the former structure features a linear arrangement of four Pd(II) centers, separated by three mechanically linked pockets, the new motif has a staggered shape. Both assemblies are topological isomers, coexisting in equilibrium in solution. The triply interlocked species is thermodynamically more stable due to extended noncovalent interactions between the ligands, as supported by X-ray structure analysis and electronic structure calculations. Notably, the degree of interlocking in the double cage system can be controlled by a change of temperature and through anion exchange. Cage-to-cage transformations were followed by NMR, MS and TIMS methods.}, archive = {J_ANGEW}, author = {Pedro Montes-Tolentino and Alexander S. Mikherdov and Christoph Drechsler and Julian J. Holstein and Guido H. Clever}, doi = {10.1002/anie.202423810}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423810}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Control of interlocking mode in Pd4L8 cage catenanes}, volume = {64}, year = {2025}, }
• (2025). Machine learning-assisted prediction of photothermal metal-phenolic networks. ANGEW, 64(13), e202423799. (www)

  @article{ , abstract = {Photothermal therapy (PTT) demonstrates significant potential in cancer treatment, wound healing, and antibacterial therapy, with its efficacy largely depending on the performance of photothermal agents (PTAs). Metal-phenolic network (MPN) materials are ideal PTA candidates due to their low cost, good biocompatibility and excellent ligand-to-metal charge transfer properties. However, not all MPNs exhibit significant photothermal properties, and the vast chemical space of MPNs (over 700,000 potential combinations) complicates the screening of high-photothermal materials. To address this challenge, this study introduces machine learning (ML) methods for predicting the photothermal performance of MPNs. A database of photothermal properties of 80 modular MPNs was constructed, and the ML process was optimized through feature engineering and model training. The selected extreme gradient boosting model (XGBoost) successfully identified 1,654 high photothermal MPNs from a virtual database of 44,438. Subsequent experimental validation revealed a remarkable success rate of 70 % in predicting high photothermal MPNs. Additionally, several previously unreported high photothermal MPNs were discovered, demonstrating advantages in photothermal antibacterial applications. This study offers an innovative ML-driven approach for the efficient screening of MPN materials, providing a solid foundation for PTA design in PTT and other biomedical applications.}, archive = {J_ANGEW}, author = {Dongqi Fan and Xu Chen and Shan Wang and Jinglei Zhan and Yuan Chen and Houqi Zhou and Dize Li and Han Tang and Qingqing He and Tao Chen}, doi = {10.1002/anie.202423799}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423799}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning-assisted prediction of photothermal metal-phenolic networks}, volume = {64}, year = {2025}, }
• (2025). Size-adjustable high-entropy alloy nanoparticles as an efficient platform for electrocatalysis. ANGEW, 64(13), e202423765. (www)

  @article{ , abstract = {The high entropy alloy (HEA) possesses distinctive thermal stability and electronic characteristics, which exhibits substantial potential for diverse applications in electrocatalytic reactions. The nanosize of HEA also has a significant impact on its catalytic performance. However, accurately controlling nanosize and synthesizing small HEA nanomaterials remains a challenge, especially for the ultrasmall HEA nanoparticles. Herein, we firstly calculate and illustrate the impact of size on the electronic structure of HEA as well as the adsorption energies of crucial intermediates involved in typical electrocatalytic processes, such as the hydrogen evolution reaction (HER), oxygen reduction reaction (ORR), CO 2 electroreduction (CO 2 RR) and NO 3 − electroreduction (NO 3 RR). Under the guidance of theoretical calculations, we synthesize a range of ultrasmall PtRuPdCoNi HEA nanoparticles with adjustable sizes (1.7, 2.3, 3.0, and 3.9 nm) using a one-step spatially confined approach, without any further treatment. Experimentally, the smaller size of HEAs is more favorable for the HER and ORR performances, aligning well with theoretical predictions. Specifically, HEA nanoparticles sized at 1.7 nm (HEA-1.7) endows a 16 mV overpotential at current density of 10 mA cm −2 , yielding a mass activity of 31.9 A mg NM −1 of noble metal in HER, significantly outperforming commercial Pt/C catalyst. This strategy can also be easily applicable to other reduction reactions (e.g. CO 2 , NO 3 − ) attributed to the richness of metal components and size adjustability, presenting a promising platform for various electrocatalytic applications as advanced catalysts.}, archive = {J_ANGEW}, author = {Huizhu Cai and Hengpan Yang and Sizhen He and Da Wan and Yan Kong and Deliang Li and Xingxing Jiang and Xue Zhang and Qi Hu and Chuanxin He}, doi = {10.1002/anie.202423765}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423765}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Size-adjustable high-entropy alloy nanoparticles as an efficient platform for electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). A BODIPY-containing covalent organic framework as a highly porous photosensitizer for environmental remediation and pollutants adsorption. ANGEW, 64(13), e202423676. (www)

  @article{ , abstract = {The direct incorporation of borondipyrromethene (BODIPY) subunits into the structural backbone of covalent organic frameworks (COFs) gives facile access to porous photosensitizers but is still a challenging task. Here, we introduce β -ketoenamine-linked BDP-TFP-COF , which crystallizes in AA-stacking mode with hcb topology. A comprehensive characterization reveals high crystallinity and enhanced stability in a variety of solvents, excellent mesoporosity (SA BET =1042 m 2 g −1 ), broad light absorption in the visible region, and red emission upon the exfoliation of few-layer COF nanosheets. The versatility of multifunctional BODIPY-COFs is highlighted in various applications. Pollutants Bisphenol A (BPA, q max =426 mg g −1 ) and Methylene Blue (MB, q max =96 mg g −1 ) have been efficiently removed from H 2 O. Fluorescence quenching or enhancement of exfoliated BDP-TFP-COF nanosheets have been utilized for dual-mode sensing of MB or NEt 3 , respectively. Ultimately, the photosensitizing effect of the BODIPY units is retained in the COF. Thus, BPD-TFP-COF was established as a metal-free triplet photosensitizer, which efficiently oxidized a mustard gas simulant under visible light irradiation.}, archive = {J_ANGEW}, author = {Roberto Sánchez-Naya and Florian Beuerle}, doi = {10.1002/anie.202423676}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423676}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A BODIPY-containing covalent organic framework as a highly porous photosensitizer for environmental remediation and pollutants adsorption}, volume = {64}, year = {2025}, }
• (2025). Sym- and asym-expanded heterohelicene isomers featuring extended multi-resonance skeleton for narrowband deep-blue fluorescence. ANGEW, 64(13), e202423670. (www)

  @article{ , abstract = {Expanded heterohelicenes composed of alternating linearly and angularly fused multi-resonance (MR) skeletons have gained wide interest owing to their promising narrowband emissions. Herein, a pair of sym - and asym -expanded heterohelicene isomers was obtained by merging boron/oxygen (B/O)-embedded MR triangulene and indolo[3,2,1- jk ]carbazole units via one-pot synthesis. Owing to their fully resonating extended helical skeleton, the target heterohelicenes exhibit a significantly narrowed spectra bandwidth while emission red-shifting, thus affording deep-blue narrowband emission with a peak at approximately 460 nm, full-width-at-half-maximum (FWHM) of only 18 nm, and near-unity photoluminescence quantum yields. In comparison to the symmetrical structure, the asym -expanded heterohelicene displays suppressed aggregation within doped films, thereby showing superior narrowband electroluminescence in devices with CIE coordinates of (0.12, 0.18) and a high external quantum efficiency of up to 25 %, which retains 18.1 % even at a high luminance of 10,000 cd m −1 . Overall, this work provides a novel paradigm for the development of narrowband expanded heterohelicenes.}, archive = {J_ANGEW}, author = {Xuan Zeng and Xiaofeng Luo and Guoyun Meng and Xuewen Wang and Dongdong Zhang and Lian Duan}, doi = {10.1002/anie.202423670}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423670}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sym- and asym-expanded heterohelicene isomers featuring extended multi-resonance skeleton for narrowband deep-blue fluorescence}, volume = {64}, year = {2025}, }
• (2025). Stabilizing lattice oxygen of Bi2O3 by interstitial insertion of indium for efficient formic acid electrosynthesis. ANGEW, 64(13), e202423658. (www)

  @article{ , abstract = {Bismuth oxide (Bi 2 O 3 ) emerges as a potent catalyst for converting CO 2 to formic acid (HCOOH), leveraging its abundant lattice oxygen and the high activity of its Bi−O bonds. Yet, its durability is usually impeded by the loss of lattice oxygen causing structure alteration and destabilized active bonds. Herein, we report an innovative approach via the interstitial incorporation of indium (In) into the Bi 2 O 3 , significantly enhancing bond stability and preserving lattice oxygen. The optimized In-Bi 2 O 3 -100 catalyst achieves over 90 % Faradaic efficiency for HCOOH production across a wide potential range, in both H-cells and flow cells, maintaining robust stability after 100 hours of continuous operation. In situ surface-enhanced infrared absorption spectroscopy and theoretical calculations reveal that the interstitial In doping precisely tunes the adsorption of CO 2 * and OCHO* intermediate, facilitating rapid conversion. Further in situ Raman spectroscopy confirms the role of In bolstering the oxidized structure's stability within Bi 2 O 3 , critical for sustaining lattice oxygen during electrochemical CO 2 reduction.}, archive = {J_ANGEW}, author = {Junjie Wang and Wu Tang and Zhaozhao Zhu and Yingxi Lin and Lei Zhao and Haiyuan Chen and Xueqiang Qi and Xiaobin Niu and Jun Song Chen and Rui Wu}, doi = {10.1002/anie.202423658}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilizing lattice oxygen of Bi2O3 by interstitial insertion of indium for efficient formic acid electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Antimicrobial phenolic materials: From assembly to function. ANGEW, 64(13), e202423654. (www)

  @article{ , abstract = {Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug-resistant pathogens that globally cause high mortality rates. These pathogens can persist on surfaces and spread in public and healthcare settings. Advances have been made in developing antimicrobial materials to reduce the transmission of pathogens, including materials composed of naturally sourced polyphenols and their derivatives, which exhibit antimicrobial potency, broad-spectrum activity, and a lower likelihood of promoting resistance. This review provides an overview of recent advances in the fabrication of antimicrobial phenolic biomaterials, where natural phenolic compounds act as active antimicrobial agents or encapsulate other antimicrobial agents (e.g., metal ions, antimicrobial peptides, natural biopolymers). Various forms of phenolic biomaterials synthesized through these two strategies, including antimicrobial particles, capsules, hydrogels, and coatings, are summarized, with a focus on their application in wound healing, bone repair and regeneration, oral health, and antimicrobial coatings for medical devices. The potential of these advanced phenolic biomaterials provides a promising therapeutic approach for combating antimicrobial-resistant infections and reducing microbial transmission.}, archive = {J_ANGEW}, author = {Wanjun Xu and Zhixing Lin and Christina Cortez-Jugo and Greg G. Qiao and Frank Caruso}, doi = {10.1002/anie.202423654}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antimicrobial phenolic materials: From assembly to function}, volume = {64}, year = {2025}, }
• (2025). Leveraging multivalent assembly towards high-temperature liquid-phase phosphorescence. ANGEW, 64(13), e202423650. (www)

  @article{ , abstract = {High-temperature phosphorescence (HTP) materials have attracted considerable attention owing to their expanded application prospects, whereas they still suffer from severe deactivation in polar media, limiting their reliability and utility. Here, we present an efficient multivalent assembly strategy to achieve high-temperature liquid-phase phosphorescence (HTLP). The supramolecular assembly of multivalent modules leads to extremely robust hydrogen-bonding networks, which firmly immobilize the organic phosphors and protect triplet excitons from annihilation in high-temperature polar media, resulting in excellent HTLP emission. Moreover, the photophysical properties of HTLP are significantly enhanced by boosting multivalent interactions using multitopic phosphors, demonstrating a visible afterglow of 5 s in boiling water, more than 2 s in dimethylsulfoxide at 460 K (187 °C), and a long lifetime of 70.3 ms in N -methylpyrrolidone at 476 K (203 °C). Based on their fluidity and robust HTLP emission, in situ microcracks detection of high-temperature operating instruments and spatial-time-temperature-resolved anticounterfeiting are demonstrated.}, archive = {J_ANGEW}, author = {Wuzhen Luo and Liming Chen and Guangqiang Yin and Chaojun Yue and Shiye Xie and Jiayin Zhou and Weihao Feng and Yujing Nie and Huakai Qiu and Feiming Li and Shunyou Cai and Yijiang Li and Zhixiong Cai and Tao Chen}, doi = {10.1002/anie.202423650}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423650}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging multivalent assembly towards high-temperature liquid-phase phosphorescence}, volume = {64}, year = {2025}, }
• (2025). Delocalized nonbonding orbitals of thioxanthone in polycyclic aromatic hydrocarbons for reduced energy gap and narrowband emission. ANGEW, 64(13), e202423602. (www)

  @article{ , abstract = {Chalcogen-containing carbonyls, specifically thioxanthone (TX), hold great potential in organic light-emitting diodes (OLEDs). While the development of narrowband OLEDs with chalcogen-containing carbonyls remains challenging due to difficulties in achieving both high device efficiency and narrow emission spectra. Herein, via a strategic incorporation of the TX moiety, two orange-red narrowband emitters, 2TXBN and BNTXBN, are designed and synthesized for the first time. Both 2TXBN and BNTXBN exhibit bright orange-red emissions with peaks at 582 and 585 nm, respectively, along with narrow full widths at half maxima of 30 and 32 nm. Notably, 2TXBN demonstrates delocalization of the nonbonding orbital within the TX segment, which raises the first triplet energy level and reduces the singlet-triplet energy gap. This electronic structural adjustment effectively shortens the delayed fluorescence lifetime, leading to enhanced device performance. Accordingly, OLED employing 2TXBN as the emitter achieves remarkable performance, with a maximum external quantum efficiency of 31.0 %, a current efficiency of 69.0 cd A −1 , and a power efficiency of 76.0 lm W −1 , highlighting the efficacy of the nonbonding orbital delocalization strategy in achieving bathochromic-shifted narrowband OLED materials.}, archive = {J_ANGEW}, author = {Zhihai Yang and Denghui Liu and Xiangyi Cheng and Tong Wang and Zhizhi Li and Guo-Xi Yang and Zijian Chen and Juntao Hu and Yu Fu and Xuewei Nie and Yongxia Ren and Yitong Zeng and Yuling Chen and Kunkun Liu and Mengke Li and Shi-Jian Su}, doi = {10.1002/anie.202423602}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Delocalized nonbonding orbitals of thioxanthone in polycyclic aromatic hydrocarbons for reduced energy gap and narrowband emission}, volume = {64}, year = {2025}, }
• (2025). Covalent adaptable poly[2]rotaxane networks via dynamic C−N bond transalkylation. ANGEW, 64(13), e202423578. (www)

  @article{ , abstract = {Covalent adaptable networks (CANs), a novel class of crosslinked polymers with dynamic covalent bonds, have gained significant attention for combining the durability of thermosets with the reprocessability of thermoplastics, making them promising for emerging applications. Here, we report the first example of poly[2]rotaxane-type covalent adaptable networks ( PR CANs), in which oligo[2]rotaxane backbones characterized by densely packed mechanical bonds, are cross-linked through dynamic C−N bonds. The oligo[2]rotaxane backbones could guarantee the mechanical properties of the CANs. Under an external force, the synergy of numerous microscopic motions of the cascade [2]rotaxane units, progressively introducing the initially hidden short chains, expands the polymer network, imparting good stretchability to the PR CANs (217 %). On the other hand, the dissociation of host-guest recognition, followed by the motion of mechanical bonds, constitutes a unique energy dissipation pathway, ultimately enhancing the toughness of PR CANs (7.6 MJ/m 3 ). In contrast, the control CAN, which lacks movable mechanical bonds, demonstrates significantly lower stretchability (40 %) and toughness (1.5 MJ/m 3 ). Moreover, the dynamic C−N bond can undergo high efficiency of 1,2,3-triazole alkylation and trans-N-alkylation exchanges at 1,2,3-triazolium sites at elevated temperatures, with good reprocessability and without compromising their mechanical performance. This work demonstrates the great potential of oligo[2]rotaxanes as a novel polymer backbone for the development of sustainable materials with excellent mechanical properties.}, archive = {J_ANGEW}, author = {Ruixue Bai and Wenbin Wang and Wenzhe Gao and Zhaoming Zhang and Wei Yu and Xuzhou Yan}, doi = {10.1002/anie.202423578}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent adaptable poly[2]rotaxane networks via dynamic C−N bond transalkylation}, volume = {64}, year = {2025}, }
• (2025). Accurate molecular sensing based on a modular and customizable CRISPR/Cas-assisted nanopore operational nexus (CANON). ANGEW, 64(13), e202423473. (www)

  @article{ , abstract = {Solid-state nanopore is a promising single molecular detection technique, but is largely limited by relatively low resolution to small-size targets and laborious design of signaling probes. Here we establish a universal, CRISPR/Cas-Assisted Nanopore Operational Nexus (CANON), which can accurately transduce different targeting sources/species into different DNA structural probes via a “Signal-ON” mode. Target recognition activates the cleavage activity of a Cas12a/crRNA system and then completely digest the blocker of an initiator. The unblocked initiator then triggers downstream DNA assembly reaction and generate a large-size structure easy for nanopore detection. Such integration of Cas12a/crRNA with DNA assembly establishes an accurate correspondence among the input targets, output DNA structures, and the ultimate nanopore signals. We demonstrated dsDNA, long RNA (i.e., Flu virus gene), short microRNA (i.e., let-7d) and non-nucleic acids (i.e., Pb 2+ ) as input paradigms. Various structural assembly reactions, such as hybridization chain reaction (HCR), G-HCR and duplex polymerization strategy (DPS), are adapted as outputs for nanopore signaling. Simultaneous assay is also verified via transferring FluA and FluB genes into HCR and G-HCR, respectively. CANON is thus a modular sensing platform holding multiple advantages such as high accuracy, high resolution and high universality, which can be easily customized into various application scenes.}, archive = {J_ANGEW}, author = {Huaning Wang and Rujian Zhao and Bing Zhang and Yao Xiao and Chunmiao Yu and Yesheng Wang and Chunxu Yu and Yidan Tang and Yanru Li and Baiyang Lu and Bingling Li}, doi = {10.1002/anie.202423473}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423473}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accurate molecular sensing based on a modular and customizable CRISPR/Cas-assisted nanopore operational nexus (CANON)}, volume = {64}, year = {2025}, }
• (2025). Confining phosphoric acid in quaternized COF channels for ultra-stable and fast anhydrous proton transport. ANGEW, 64(13), e202423458. (www)

  @article{ , abstract = {Phosphoric acid (H 3 PO 4 ) doping is a widely employed strategy to facilitate anhydrous proton transport in high-temperature proton exchange membrane fuel cells (HT-PEMFCs). However, significant H 3 PO 4 leaching during long-term operation poses critical challenges to maintaining membrane stability and proton conductivity. Herein, H 3 PO 4 is incorporated into positively charged nanochannels of quaternized covalent organic framework membranes (QACOFMs), leveraging strong electrostatic interactions and confinement effects to achieve exceptional H 3 PO 4 retention under hydration conditions. Moreover, the shortened hydrogen bond length between H 3 PO 4 (O−H…O <2.7 Å) and the highly interconnected hydrogen bond network in the H 3 PO 4 @QACOFMs facilitate ultra-fast anhydrous proton transport. As a result, the H 3 PO 4 @QACOFMs exhibit superior anhydrous proton transport in a broader temperature range (60 °C–200 °C) and the highest proton conductivity reaches about 379.7 mS cm −1 at 200 °C.}, archive = {J_ANGEW}, author = {Xiao Pang and Benbing Shi and Yawei Liu and Hong Wu and Jianliang Shen and Jingyuan Guan and Xiaoyao Wang and Chunyang Fan and Li Cao and Tianhao Zhu and Yan Kong and Zhongyi Jiang}, doi = {10.1002/anie.202423458}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423458}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Confining phosphoric acid in quaternized COF channels for ultra-stable and fast anhydrous proton transport}, volume = {64}, year = {2025}, }
• (2025). Anchoring sn nanoparticles in necklace-like B,N,F-doped carbon fibers enables anode-less 5V-class li-metal batteries. ANGEW, 64(13), e202423454. (www)

  @article{ , abstract = {Li metal batteries (LMBs), particularly with a limited Li metal anode and a 5V-class cathode, offer significantly higher energy density compared to the state-of-the-art Li-ion batteries. However, the limited Li anode poses severe challenges to cycling stability due to low efficiency and large volume expansion issues associated with Li. Herein, we design a lightweight and functionalized host composed of Sn nanoparticles embedded into necklace-like B,N,F-doped carbon macroporous fibers (Sn@B/N/F-CMFs) toward anode-less 5V-class LMBs. The macroporous framework can decrease the local current density to homogenize Li deposition and release structural stress to realize high areal capacity of over 40 mAh cm −2 . The lithiophilic B,N,F-doped carbon and Sn nanoparticles can function as high-affinity Li + binding sites to uniformize Li nucleus growth on the internal and external surface of hollow fibers. Accordingly, the Sn@B/N/F-CMFs enable stable dendrite-free Li plating/stripping behaviors for 1700 h even in the carbonate-based electrolyte. When coupled with a 5V-class LiNi 0.5 Mn 1.5 O 4 cathode, the assembled anode-less pouch cell also displays stable cycling performance even under harsh conditions.}, archive = {J_ANGEW}, author = {Yuan Tian and Zhihao Pei and Deyan Luan and Xiong Wen (David) Lou}, doi = {10.1002/anie.202423454}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423454}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anchoring sn nanoparticles in necklace-like B,N,F-doped carbon fibers enables anode-less 5V-class li-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Chiral nanofibers of camptothecin trigger pyroptosis for enhanced immunotherapy. ANGEW, 64(13), e202423446. (www)

  @article{ , abstract = {Camptothecin (CPT), a chemotherapeutic agent, demonstrates significant potential in cancer therapy. However, as a drug, CPT molecule suffers from poor water solubility, limited bioavailability, and insufficient immune response. Herein, we construct CPT nanofibers (CNF) with a right-handed chiral property via supramolecular self-assembly, which significantly overcomes the solubility barriers associated with bioavailability and improves tumor immune prognosis. The CNF exhibits high chiral asymmetry factor ( g abs ) (~0.11) and remarkable structure stability under pH 6.5 condition. By formulating chiral CNF with mitochondrial-targeted DSPE-PEG-TPP, CNF accumulates specifically in the mitochondria of cancer cells, leading to mitochondrial dysfunction and a 3.42-fold increase in reactive oxygen species (ROS) generation compared to the CPT molecule. This ROS amplification activates the caspase-1/gasdermin D (GSDMD) pathway, inducing pyroptosis that promotes M1 macrophage polarization and enhances CD8 + T-cell-dependent antitumor immunity. Consequently, CNF achieves 1.8-fold greater growth inhibition of distant tumor and reduces tumor metastasis compared to the CPT molecule. Our innovative platform, assembling CPT molecules into chiral CNF structure, is highly anticipated to overcome the current clinical limitations of CPT molecules and offer a new direction for the development of next-generation immunotherapy strategies.}, archive = {J_ANGEW}, author = {Fengli Gao and Xiaxin Qiu and Sravan Baddi and Sijia He and Shuting Wang and Changli Zhao and Xiaoqiu Dou and Chuanliang Feng}, doi = {10.1002/anie.202423446}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423446}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral nanofibers of camptothecin trigger pyroptosis for enhanced immunotherapy}, volume = {64}, year = {2025}, }
• (2025). CeO2 modification promotes the oxidation kinetics for adipic acid electrosynthesis from KA oil oxidation at 200 mA cm−2. ANGEW, 64(13), e202423432. (www)

  @article{ , abstract = {Electrocatalytic oxidation of cyclohexanol/cyclohexanone in water provides a promising strategy for obtaining adipic acid (AA), which is an essential feedstock in the polymer industry. However, this process is impeded by slow kinetics and limited Faradaic efficiency (FE) due to a poor understanding of the reaction mechanism. Herein, NiCo 2 O 4 /CeO 2 is developed to enable the electrooxidation of cyclohexanol to AA with a 0.0992 mmol  h −1 cm −2 yield rate and 87 % Faradaic efficiency at a lower potential. Mechanistic investigations demonstrate that cyclohexanol electrooxidation to AA is a gradual oxidation process involving the dehydrogenation of cyclohexanol to cyclohexanone, the generation of 2-hydroxy cyclohexanone, and subsequent C−C cleavage. Theoretical calculations reveal that electronic interactions between CeO 2 and NiCo 2 O 4 decrease the energy barrier of cyclohexanone oxidation to 2-hydroxy cyclohexanone and inhibit the *OH to *O step, leading to AA electrosynthesis with a high yield rate and FE. Kinetic analysis further elucidates the effect of CeO 2 on promoting cyclohexanone adsorption and activation on the electrode surface, thus facilitating the reaction kinetics. Moreover, a two-electrode flow reactor is constructed to produce 72.1 mmol AA and 10.4 L H 2 by using KA oil as the anode feedstock at 2.5 A (200 mA cm −2 ), demonstrating promising potential.}, archive = {J_ANGEW}, author = {Shuoshuo Guo and Changhong Wang and Huizhi Li and Tieliang Li and Cuibo Liu and Ying Gao and Bo-Hang Zhao and Bin Zhang}, doi = {10.1002/anie.202423432}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423432}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CeO2 modification promotes the oxidation kinetics for adipic acid electrosynthesis from KA oil oxidation at 200 mA cm−2}, volume = {64}, year = {2025}, }
• (2025). Phosphorescent liquid crystalline polymer-based circularly polarized luminescence optical waveguides for enhanced photonic signal processing and information encryption. ANGEW, 64(13), e202423395. (www)

  @article{ , abstract = {Efficient circularly polarized luminescence (CPL) optical waveguides have significant potential for advancing photonic and optoelectronic devices. However, the development of CPL optical waveguides materials (OWMs) with low optical loss coefficient remains a considerable challenge. To overcome this, we design and synthesize CPL OWMs based on room-temperature phosphorescent liquid crystalline polymers (LCPs). Experimental results demonstrate that these LCPs exhibit a nematic liquid crystal phase and a phosphorescence lifetime of approximately 0.145 ms. By introducing a chiral dopant, we induce a chiral arrangement in the LCPs, followed by crosslinking via photo-cycloaddition and removal of the chiral dopants through solvent soaking. The resulting polymers exhibit stable solvent resistance and highly efficient circularly polarized phosphorescence (CPP) properties, with dissymmetric factors ( g RTP ) in the range of 0.16 to 0.17. Notably, the CPP-active OWMs exhibit efficient circularly polarized photonic signal waveguiding, with an optical loss coefficient of approximately 0.175 dB/mm. Ultimately, these CPP-active OWMs are sucessfully applied in information encryption, decryption, and optical switching, paving the way for advanced photonic and optoelectronic devices.}, archive = {J_ANGEW}, author = {Jie Li and Yan Guan and Tian-Tian Hao and Jiang Huang and Yi Chen and Heng Li and Pengfei Duan and He-Lou Xie}, doi = {10.1002/anie.202423395}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423395}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phosphorescent liquid crystalline polymer-based circularly polarized luminescence optical waveguides for enhanced photonic signal processing and information encryption}, volume = {64}, year = {2025}, }
• (2025). Chlorine-doped SnO2 nanoflowers on nickel hollow fiber for enhanced CO2 electroreduction at ampere-level current densities. ANGEW, 64(13), e202423370. (www)

  @article{ , abstract = {Renewable energy-driven electrochemical CO 2 reduction has emerged as a promising technology for a sustainable future. However, achieving efficient production of storable liquid fuels at ampere-level current densities remains a significant hurdle in the large-scale implementation of CO 2 electroreduction. Here we report a novel catalytic electrode comprising chlorine-doped SnO 2 nanoflowers arrayed on the exterior of three-dimensional nickel hollow fibers. This electrode demonstrates exceptional electrocatalytic performance for converting CO 2 to formate, achieving a remarkable formate selectivity of 99 % and a CO 2 single-pass conversion rate of 93 % at 2 A cm −2 . Furthermore, it exhibits excellent stability, maintaining a formate selectivity of above 94 % for 520 h at a current density of 3 A cm −2 . Experimental results combined with theoretical calculations confirm that the enhanced mass transfer facilitated by the hollow fiber penetration effect, coupled with the well-retained Sn 4+ species and Sn−Cl bonds, synergistically elevates the activity of CO 2 conversion. The incorporation of chlorine into SnO 2 enhances electron transport and CO 2 adsorption, substantially lowering the reaction energy barrier for the crucial intermediate *OCHO formation, and boosting the formate production.}, archive = {J_ANGEW}, author = {Yiheng Wei and Xiaotong Wang and Jianing Mao and Yanfang Song and Huanyi Zhu and Xiaohu Liu and Cheng Luo and Shoujie Li and Aohui Chen and Guihua Li and Xiao Dong and Wei Wei and Wei Chen}, doi = {10.1002/anie.202423370}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423370}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chlorine-doped SnO2 nanoflowers on nickel hollow fiber for enhanced CO2 electroreduction at ampere-level current densities}, volume = {64}, year = {2025}, }
• (2025). Topological insulator heterojunction with electric dipole domain to boost polysulfide conversion in lithium-sulfur batteries. ANGEW, 64(13), e202423357. (www)

  @article{ , abstract = {The heterojunction materials are considered as promising electrocatalyst candidates that empower advanced lithium-sulfur (Li−S) batteries. However, the detailed functional mechanism of heterojunction materials to boost the sulfur redox reaction kinetics remains unclear. Herein, we construct a multifunctional potential well-type Bi 2 Te 3 /TiO 2 topological insulator (TI) heterojunction with electric dipole domain to elucidate the synergistic mechanism, which facilitates rapid mass transport, strengthens polysulfide capture ability and accelerates polysulfide conversion. Therefore, the Li−S battery with Bi 2 Te 3 /TiO 2 TI heterojunction modified separator achieves high utilization of sulfur cathode, delivering a high reversible specific capacity of 1375 mAh g −1 at 0.2 C and long cycling capability with a negligible capacity decay of 0.022 % per cycle over 1000 cycles at 1 C. Even with the high sulfur loading of 13.2 mg cm −2 and low E/S ratio of 3.8 μL mg −1 , a high area capacity of 11.2 mAh cm −2 and acceptable cycling stability can be obtained. This work provides guidance for designing high-efficiency TI heterojunctions to promote the practical application of Li−S batteries.}, archive = {J_ANGEW}, author = {Hedong Chen and Yecheng Qiu and Zhiyuan Cai and Wenhao Liang and Lin Liu and Manman Li and Xianhua Hou and Fuming Chen and Xunzhu Zhou and Tengfei Cheng and Liqing He and Jiazhao Wang and Xiao Zhang and Shixue Dou and Lin Li}, doi = {10.1002/anie.202423357}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topological insulator heterojunction with electric dipole domain to boost polysulfide conversion in lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Establishing the link between oxygen vacancy and activity enhancement in acidic water oxidation of trigonal iridium oxide. ANGEW, 64(13), e202423353. (www)

  @article{ , abstract = {Developing durable IrO 2 -based electrocatalysts with high oxygen evolution reaction (OER) activity under acidic condition is crucial for proton exchange membrane electrolyzers. While oxygen defects are considered potentially important in OER, their direct relationship with catalytic activity has yet to be established. In this study, we introduced abundant oxygen vacancies through Re doping in 2D IrO 2 (Re 0.03 Ir 0.97 O 2 ), demonstrating their decisive role in enhancing OER performance. The Re 0.03 Ir 0.97 O 2 catalyst exhibited excellent OER performance with an overpotential of 193 mV at 10 mA cm −2 and sustained activity for over 650 hours, significantly surpassing the undoped catalyst. Moreover, it maintained operation at a cell voltage of 1.70 V (~1200 mA cm −2 ) for over 140 hours without significant performance degradation. Theoretical calculations coupled with cyclic voltammetry, transient potential scanning and in situ characterizations confirmed the adsorbate evolving mechanism on Re 0.03 Ir 0.97 O 2 , as well as the critical role of Re-induced oxygen vacancies in enhancing OER performance. These findings highlight that oxygen defects directly influence OER activity, providing guidance for the application of oxygen vacancy engineering in electrocatalyst design.}, archive = {J_ANGEW}, author = {Wenxiang Zhu and Mengjie Ma and Dongdong Gao and Jinxin Chen and Hui Huang and Kun Feng and Qun Wang and Jie Wu and Penghao Li and Jinzeng Guo and Zhenglong Fan and Jun Zhong and Qi Shao and Fan Liao and Yang Liu and Mingwang Shao and Zhenhui Kang}, doi = {10.1002/anie.202423353}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Establishing the link between oxygen vacancy and activity enhancement in acidic water oxidation of trigonal iridium oxide}, volume = {64}, year = {2025}, }
• (2025). A low-symmetry copper benzenehexathiol coordination polymer with in-plane electrical anisotropy. ANGEW, 64(13), e202423341. (www)

  @article{ , abstract = {Electrically conductive coordination polymers (ECCPs), particularly those incorporating benzenehexathiol (BHT) ligands, are emerging as a distinctive class of electronic materials with tunable semiconducting and metallic properties. However, the exploration of novel ECCPs with low-symmetry structures and electrical anisotropy remains under development. Here, we report the on-water surface synthesis of a novel ECCP, namely Cu 5 BHT, which exhibits a low-symmetry structure and unique in-plane electrical anisotropy that differs from the well-known Cu 3 BHT phase. Utilizing imaging and diffraction techniques, we elucidate the unit cell and crystal structure of Cu 5 BHT, revealing an asymmetric arrangement of the kagome resembling lattice connected by two different secondary building units: square planar CuS 4 and non-planar Cu 2 S 4 . Theoretical studies indicate that Cu 5 BHT is metallic and exhibits in-plane electrical anisotropy due to the structure arranged in interconnected well-conducting CuS 4 chains and less-conducting Cu 2 S 4 slabs oriented along single crystal direction. Single-crystal electrical measurements confirm a metallic character characterized by the increase of conductance upon cooling. Notably, the measured conductance along different crystal directions within the ab plane unambiguously reveals a significant anisotropy, with an anisotropic factor reaching ~8. This work demonstrates a novel low-symmetry ECCP and highlights its potential for achieving in-plane electrical anisotropy.}, archive = {J_ANGEW}, author = {Zhiyong Wang and Hio-Ieng Un and Tsai-Jung Liu and Baokun Liang and Miroslav Polozij and Mike Hambsch and Jonas F. Pöhls and R. Thomas Weitz and Stefan C. B. Mannsfeld and Ute Kaiser and Thomas Heine and Henning Sirringhaus and Xinliang Feng and Renhao Dong}, doi = {10.1002/anie.202423341}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423341}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A low-symmetry copper benzenehexathiol coordination polymer with in-plane electrical anisotropy}, volume = {64}, year = {2025}, }
• (2025). 1.5D chiral perovskites mediated by hydrogen-bonding network with remarkable spin-polarized property. ANGEW, 64(13), e202423314. (www)

  @article{ , abstract = {In this study, we developed new chiral hybrid perovskites, ( R / S -MBA)(GA)PbI 4 , by incorporating achiral guanidinium (GA + ) and chiral R / S -methylbenzylammonium ( R / S -MBA + ) into the perovskite framework. The resulting materials possess a distinctive structural configuration, positioned between 1D and 2D perovskites, which we describe as 1.5D. This structure is featured by a hydrogen-bonding-network-induced arrangement of zigzag inorganic chains, further forming an organized layered architecture. The structural dimensionality affects both electronic and spin-related properties. Density functional theory (DFT) calculations reveal Rashba splitting induced by the inversion asymmetry of the crystal structure, while circularly polarized transient absorption spectroscopy confirms spin lifetime on the nanosecond timescale. Magnetic conductive-probe atomic force microscopy (mCP-AFM) measurements demonstrate exceptional chiral-induced spin selectivity (CISS) with maximum spin polarization degrees of (92±1)% and (−94±2)% for ( R -MBA)(GA)PbI 4 and ( S -MBA)(GA)PbI 4 , respectively. These findings underscore the potential of ( R / S -MBA)(GA)PbI 4 as promising candidates for next-generation spintronic devices, also highlight the critical role of chemical environment in sculpturing the structural dimension and spin-polarized property of chiral perovskites.}, archive = {J_ANGEW}, author = {Shuo Sun and Jiawei Jiang and Menghui Jia and Yunfei Tian and Yin Xiao}, doi = {10.1002/anie.202423314}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {1.5D chiral perovskites mediated by hydrogen-bonding network with remarkable spin-polarized property}, volume = {64}, year = {2025}, }
• (2025). Tailoring water-in-DMSO electrolyte for ultra-stable rechargeable zinc batteries. ANGEW, 64(13), e202423302. (www)

  @article{ , abstract = {Rechargeable zinc batteries (RZBs) are hindered by two primary challenges: instability of Zn anode and deterioration of the cathode structure in traditional aqueous electrolytes, largely attributable to the decomposition of active H 2 O. Here, we design and synthesize a non-flammable water-in-dimethyl sulfoxide electrolyte to address these issues. X-ray absorption spectroscopy, in situ techniques and computational simulations demonstrate that the activity of H 2 O in this electrolyte is extremely compressed, which not only suppresses the side reactions and increases the reversibility of Zn anode, but also diminishes the cathode dissolution and proton intercalation. The hybrid solid-electrolyte interface (SEI), formed in situ, helps Zn−Zn symmetric cell a prolonged lifespan exceeding 10000 h at 0.5 mA cm −2 and 600 h at a 60 % discharge depth. The versatility of this electrolyte endows the Zn-VO 2 full batteries ultra-stable cycling performance. This work provides insights into electrolyte structure–property relationships, and facilitates the design of high-performance RZBs.}, archive = {J_ANGEW}, author = {Huaizheng Ren and Sai Li and Liang Xu and Lei Wang and Xinxin Liu and Yue Liu and Liang Zhang and Han Zhang and Yuxin Gong and Chade Lv and Dongping Chen and Jianxin Wang and Qiang Lv and Yaqiang Li and Huakun Liu and Dianlong Wang and Tao Cheng and Bo Wang and Dongliang Chao and Shixue Dou}, doi = {10.1002/anie.202423302}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423302}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring water-in-DMSO electrolyte for ultra-stable rechargeable zinc batteries}, volume = {64}, year = {2025}, }
• (2025). One-pot transition-metal-free synthesis of π-extended bipolar polyaromatic hydrocarbons. ANGEW, 64(13), e202423282. (www)

  @article{ , abstract = {The development of straightforward synthetic methods for photoactive polycyclic aromatic hydrocarbons (PAHs) that avoid Pd-catalyzed or radical-based processes remains a challenge. Such methods are essential to reducing the cost and environmental impact of organic photodevices. In this work, we present a one-pot synthetic approach for creating novel bipolar PAHs with extended π-conjugation, which are not accessible via conventional Pd-catalyzed routes. Our cascade process operates exclusively under basic conditions, utilizing cesium carbonate and molecular sieves to facilitate the coupling of electron-deficient 4-fluoronaphthalene-1,8-dicarboximide with halogenated electron-rich moieties. This results in the regio- and chemoselective formation of new 6- and/or 5-membered conjugated rings via consecutive SN Ar reactions, as confirmed through experimental and computational studies. The resulting PAHs exhibit strong emissive properties, with quantum yields ranging from 34 % to 99 %. This work provides a simple and efficient synthetic strategy for producing novel semiconducting materials, offering a new framework for designing bipolar PAHs with distinct optical characteristics.}, archive = {J_ANGEW}, author = {Krzysztof Bartkowski and Emran Masoumifeshani and Urszula Klimczak and Martyna Kotowska and Bartłomiej Furman and Cina Foroutan-Nejad and Marcin Lindner}, doi = {10.1002/anie.202423282}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423282}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-pot transition-metal-free synthesis of π-extended bipolar polyaromatic hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). CsPbBr3 superstructures with circularly polarized photolumines-cence obtained by the self-assembly and annealing of nanoclusters. ANGEW, 64(13), e202423272. (www)

  @article{ , abstract = {We report a two-step approach to fabricate CsPbBr 3 superstructures with strongly circularly polarized photoluminescence by self-assembly of nanoclusters on a substrate, followed by their annealing. In the first step, the nanoclusters self-assemble upon solvent evaporation, a process that forms mesoscopic superstructures whose geometrical arrangement at the μm-scale confers them optical chirality. In the second step, mild annealing of such superstructures induces the coalescence of the nanoclusters, accompanied by a continuous red shift of the photoluminescence up to 530 nm, with preservation of the μm-scale wires bundles and the chiral properties of the sample (g lum =0.1). The successful chirality transfer from the initial nanoclusters assemblies to these final CsPbBr 3 superstructures provides a convenient way to obtain circularly polarized emitters.}, archive = {J_ANGEW}, author = {Baowei Zhang and Jian Xiao and Zhengkun Xie and Maowei Jiang and Haoqiang Song and Stefano Toso and Shuangquan Zang and Liberato Manna and Siyu Lu}, doi = {10.1002/anie.202423272}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423272}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CsPbBr3 superstructures with circularly polarized photolumines-cence obtained by the self-assembly and annealing of nanoclusters}, volume = {64}, year = {2025}, }
• (2025). Heteroarchitectural gas diffusion layer promotes CO2 reduction coupled with biomass oxidation at ampere-level current density. ANGEW, 64(13), e202423263. (www)

  @article{ , abstract = {Achieving high product selectivity at ampere-level current densities is essential for the industrial application of electrochemical CO 2 reduction. However, the operational stability of CO 2 electrolyzers at large current density has long been hindered by flooding of gas diffusion layer (GDL). Herein, a new heteroarchitectural GDL is designed to overcome flooding. Such GDL is constructed by sequentially sputtering the conductive silver and titanium boride (TiB 2 ) onto a polytetrafluoroethylene substrate. Assembled with Cu catalyst in a flow cell, a maximum ethylene Faradaic efficiency of 64.7 % was achieved at a current density of 1.2 A cm −2 in 6 M KOH. Furthermore, the GDL is capable of stable operation for over 40 hours at 400 mA cm −2 . Theoretical calculations and in situ experiments demonstrate enhanced intermediates adsorption on the TiB 2 -supported Cu surface, thereby reducing the energy barrier for C−C coupling. When coupling the CO 2 reduction reaction with 5-hydroxymethylfurfural oxidation reaction, Faradaic efficiencies of 49.2 % for ethylene and 85.4 % for 2,5-furandicarboxylic acid were achieved at 1.2 A cm −2 . This work provides a highly stable GDL for efficient CO 2 conversion at ampere-level current density and paves the way for integrating biomolecules conversion in stack-level devices.}, archive = {J_ANGEW}, author = {Chenbao Lu and Pengfei Shi and Senhe Huang and Chongqing Yang and Jinhui Zhu and Jichao Zhang and Changchun Ke and Yuezeng Su and Xiaodong Zhuang and Tianfu Wang}, doi = {10.1002/anie.202423263}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423263}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heteroarchitectural gas diffusion layer promotes CO2 reduction coupled with biomass oxidation at ampere-level current density}, volume = {64}, year = {2025}, }
• (2025). Ultrastable imidazole-linked porous organic cages for ammonia capture and detection. ANGEW, 64(13), e202423226. (www)

  @article{ , abstract = {Here, we report the facile synthesis of imidazole-linked porous organic cages (IPOCs) via an in situ cyclization reaction protocol. Specifically, three IPOCs with [2+4] lantern-like structures and one with a [3+6] triangular prism structure were successfully prepared through condensation reactions between tetraformyl-functionalized calix[4]arene and bis(o-phenylenediamine) monomers in a single pot. Notably, these IPOCs exhibit high porosity, with Brunauer–Emmett–Teller (BET) specific surface areas reaching up to 1162 m 2 g −1 . Moreover, they demonstrate excellent chemical stability in both strong acidic and alkaline solutions. Furthermore, IPOC-2 and IPOC-4 display a remarkable NH 3 capturing capability, with uptakes of up to 11.5 mmol g −1 at 1 bar and 298 K, surpassing most reported porous organic materials. Additionally, IPOC-1 exhibits highly efficient fluorescent quenching sensing of aqueous NH 3 , with a detection limit as low as 3.35×10 −6 M. These findings strongly suggest the potential for widespread use of imidazole linkages in the development of robust functional porous organic cage materials for diverse applications.}, archive = {J_ANGEW}, author = {Guoshi Zhang and Ning Xu and Miao Yang and Wenjing Wang and Kongzhao Su and Daqiang Yuan}, doi = {10.1002/anie.202423226}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423226}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrastable imidazole-linked porous organic cages for ammonia capture and detection}, volume = {64}, year = {2025}, }
• (2025). Autocatalytic interfacial synthesis of self-standing amide-linked covalent organic framework membranes. ANGEW, 64(13), e202423220. (www)

  @article{ , abstract = {The synthesis of crystalline covalent organic frameworks (COFs) has in principle relied on reversible dynamic chemistry. A general method to synthesize irreversibly bonded COFs is urgently demanded for driving the COF chemistry to a new era. Here we report a universal two-step method for the straightforward synthesis of irreversibly amide-linked COF (AmCOF) membranes by autocatalytic interfacial polymerization (AIP). Highly crystalline amide and imine bilinker COF (AICOF) membranes are readily synthesized by AIP strategy which ingeniously leverages interfacial polymerization to generate amide units followed by an autocatalytic condensation that forms imine bonds. Then, the fully amide-linked AmCOF membranes with Turing structures can be prepared through irreversible linker renovation. The universality of this method has been exemplified by nine AmCOF membranes. Among them, the AmCOF-1 membrane exhibits superior performance for H 2 O 2 photosynthesis (4353 μmol g −1 h −1 ) and high stability, enabling continuous production of H 2 O 2 under sunlight for 150 h without sacrificial agents. Mechanistic investigations reveal that the greatly improved properties are attributable to the built-in robust amide knots, facilitating full separation of electrons and holes, ultra-long exciton diffusion length, and fast dissociation of excitons within the AmCOF channels.}, archive = {J_ANGEW}, author = {Lei Fang and Hui Xu and Suyu Qiu and Tao Ye and Tianqi Wang and Jin Shang and Cheng Gu and Susumu Kitagawa and Liangchun Li}, doi = {10.1002/anie.202423220}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423220}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Autocatalytic interfacial synthesis of self-standing amide-linked covalent organic framework membranes}, volume = {64}, year = {2025}, }
• (2025). Porphyrin-based vinylene-linked 3D covalent organic framework with unprecedented cya topology for photocatalytic H2O2 production. ANGEW, 64(13), e202423205. (www)

  @article{ , abstract = {Designing and realizing new topologies represent one of the most important ways toward developing new structures and functionalities for molecule-based frameworks including SOFs, MOFs, and COFs. Herein, Aldol condensation between 5,10,15,20-tetrayl(tetrakis(([1,1′:3′,1′′-terphenyl]-4,4′′-dicarbaldehyde)))-porphyrin (TTEP) and 2,4,6-trimethyl-1,3,5-triazine (TMT) affords the vinylene-linked 3D covalent organic framework Por-COF- cya . Powder X-ray diffraction (PXRD) in combination with structural simulation reveals its high crystalline structure with an unprecedented cya topology in the molecule-based frameworks reported thus far. Por-COF- cya displayed polycrystallinity and possessed high permanent porosity. Especially, the incorporation of light-harvesting porphyrin unit and vinylene linkages in Por-COF- cya enables a conjugation effect within the framework, endowing it with a photocatalytic H 2 O 2 production rate of 2209 μmol g −1 h −1 in pure aqueous solution under visible-light irradiation (λ >420 nm). Inclusion of the guest molecules TTF into the pores of Por-COF- cya results in a donor-acceptor system TTF@Por-COF- cya , enhancing the photocatalytic activity with H 2 O 2 production rate of 6994 μmol g −1 h −1 . This work paves a new way for the development of new topological functional molecule-based frameworks toward diverse application potentials.}, archive = {J_ANGEW}, author = {Zihan Gong and Ying Gao and Jing Li and Zichen Cai and Naifang Liu and Jianzhuang Jiang}, doi = {10.1002/anie.202423205}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423205}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porphyrin-based vinylene-linked 3D covalent organic framework with unprecedented cya topology for photocatalytic H2O2 production}, volume = {64}, year = {2025}, }
• (2025). In situ growth of metal-organic layer on polyoxometalate-etching Cu2O to boost CO2 reduction with high stability. ANGEW, 64(13), e202423204. (www)

  @article{ , abstract = {Low-cost Cu 2 O with a suitable band gap holds great potential for solar utilization. However severe photocorrosion and weak CO 2 capture capability have significantly hindered their application in artificial photosynthesis. Herein, polyoxometalate (POM)-etching and in situ growth of metal–organic framework (MOF) can simultaneously incorporate electron-sponge and HKUST protective layer into Cu 2 O. The resulting ternary composites Cu 2 O@POM@HKUST-n (POM=PMo 12 O 40 and PW 12 O 40 ) with dual hetero-interfaces can efficiently convert CO 2 to HCOOH with 5226 μmol g −1 yield, over 5 and 55 times higher than that of Cu 2 O (1010 μmol g −1 ) and Cu 2 O@HKUST (95.02 μmol g −1 ). In situ XPS and DFT studies reveal that Cu mainly existed in the form of Cu 2 O and Cu-MOF, while a unique Cu x+ (1<x≤2) surface layer formed upon the Cu 2 O matrix surrounding POMs for CO 2 absorption and activation. Systematic investigations demonstrate that the electron-sponge can efficiently capture electrons from excited Cu 2 O to promote the generation of a Cu x+ surface layer, while the closely surface-coating metal-organic layer can act as protective layer and CO 2 adsorbent. This dual function concurrently contributes to promote photocatalysis and prevent Cu 2 O degradation. Remarkably, the composites exhibit much enhanced photochemical stability and can be used for over 60 h without noticeable activity loss.}, archive = {J_ANGEW}, author = {Yu-Jie Wang and Xin Cheng and Na-Na Ma and Wei-Yi Cheng and Peng Zhang and Fang Luo and Wen-Xiong Shi and Shuang Yao and Tong-Bu Lu and Zhi-Ming Zhang}, doi = {10.1002/anie.202423204}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423204}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ growth of metal-organic layer on polyoxometalate-etching Cu2O to boost CO2 reduction with high stability}, volume = {64}, year = {2025}, }
• (2025). Highly efficient photocatalytic CO2-to-CO on ni-based cationic polymer with TiO2-assisted exfoliation and stabilization. ANGEW, 64(13), e202423200. (www)

  @article{ , abstract = {Porous organic polymers have shown great potential in photocatalytic CO 2 reduction due to their unique tunable structure favoring gas adsorption and metal sites integration. However, efficient photocatalysis in porous polymers is greatly limited by the low surface reactivity and electron mobility of bulk structure. Herein, we incorporate TiO 2 nanoparticles and Ni(II) sites into a layered cationic imidazolium polymer (IP), in which the imidazolium moieties and free anions can stabilize the key intermediates and enhance the reaction kinetics of CO 2 reduction. During the photocatalytic reaction, the layered TiO 2 /NiIP is in situ exfoliated to nanosheets (NSs) with more accessible active sites and shorten electron transport pathways. The formed TiO 2 /NiIP-NSs exhibit an impressively high CO production rate as 54.9 mmol ⋅ g −1 ⋅ h −1 with selectivity of 99.9 %. The embedding with TiO 2 nanoparticles could improve the electron transport efficiency so as to facilitate the photochemical stripping process of layered polymer. Moreover, the exfoliated nanosheets with assistance of TiO 2 possess excellent stability during the recycling experiments in comparison to the rapidly declined activity of NiIP-NSs. This work presents a new strategy to construct highly efficient photocatalysts for CO 2 reduction.}, archive = {J_ANGEW}, author = {Can Wu and Ke Song and Xiting Zhang and Bien Tan and Rongzhen Liao and Zhao-Qing Liu and Huaiyong Zhu and Jingyu Wang}, doi = {10.1002/anie.202423200}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423200}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient photocatalytic CO2-to-CO on ni-based cationic polymer with TiO2-assisted exfoliation and stabilization}, volume = {64}, year = {2025}, }
• (2025). Efficient and robust Europium(III)-based hybrid lanthanide scintillators for advanced X-ray imaging. ANGEW, 64(13), e202423155. (www)

  @article{ , abstract = {Scintillators that convert ionizing radiation into low-energy photons are essential for medical diagnostics and industrial inspections. Despite advances in X-ray scintillators, challenges remain in achieving high efficiency, environmental compatibility, stability, and flexibility. Here, we present experimental investigations of a new type of europium(III)-based hybrid ternary complex scintillators for improved X-ray detection and imaging. Benefiting from the synergistic interaction between dual organic ligands and lanthanide ions, the Eu(TTA) 3 Phen complex demonstrates exceptional radioluminescence and light yield under X-ray excitation, with a detection limit of 19.97 nGy s −1 , well below typical radiation doses used in medical diagnostics. Moreover, lanthanide complex Eu(TTA) 3 Phen exhibited excellent thermal and photostability, showing minimal degradation even after extended X-ray exposure. By integrating with flexible polymer matrices, a high-transmission Eu(TTA) 3 Phen-PMMA composite film was fabricated for X-ray radiography, demonstrating high spatial resolution (<10 um) and superior image quality across various target samples. These findings hold substantial promise for next-generation X-ray imaging applications, offering high sensitivity, stability, flexibility, and versatility, making them ideally suited for advanced radiographic systems.}, archive = {J_ANGEW}, author = {Yimei Zhang and Tingli Du and Han Duan and Binqi Chen and Jiahui Zhang and Qin Xiao and Geng Chen and Dongxin Guo and Hong Liao and Si Zhou and Kezhi Zheng}, doi = {10.1002/anie.202423155}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423155}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient and robust Europium(III)-based hybrid lanthanide scintillators for advanced X-ray imaging}, volume = {64}, year = {2025}, }
• (2025). Mesoporous cu nanoplates with exposed cu+ sites for efficient electrocatalytic transfer semi-hydrogenation of alkynes. ANGEW, 64(13), e202423112. (www)

  @article{ , abstract = {Electrocatalytic transfer alkyne semi-hydrogenation with H 2 O as hydrogen source is industrially promising for selective electrosynthesis of high value-added alkenes while inhibiting byproduct alkanes. Although great achievements, their development has remarkably restricted by designing atomically sophisticated electrocatalysts. Here, we reported single-crystalline mesoporous copper nanoplates ( meso -Cu PLs) as a robust yet highly efficient electrocatalyst for selective alkene electrosynthesis from transfer semi-hydrogenation reaction of alkyne in H 2 O. Anisotropic meso -Cu PLs were prepared through a facile epitaxial growth strategy with functional C 22 H 45 N(CH 3 ) 2 -C 3 H 6 -SH as concurrent mesopore-forming and structure-controlled surfactant. Different to nonporous Cu counterparts with flat surface, meso -Cu PLs with spherical mesopores exposed abundant Cu + sites, which not only stabilized active H* radicals from electrocatalytic H 2 O splitting without coupling into molecular H 2 but also accelerated kinetically the desorption of semi-hydrogenated alkenes. With 4-aminophenylacetylene (4-AP) as the substrate, anisotropic meso -Cu PLs delivered superior electrocatalytic transfer semi-hydrogenation performance with up to 99 % of 4-aminostyrene selectivity and 100 % of 4-AP conversion as well as good cycle stability. Meanwhile, meso -Cu PLs were electrocatalytically applicable for transfer semi-hydrogenation of various alkynes. This work thus paved an alternative paradigm for designing robust mesoporous metal electrocatalysts with structurally functional metal sites applied in the selective electrosynthesis of industrially value-added chemicals in H 2 O.}, archive = {J_ANGEW}, author = {Hao Lv and Lizhi Sun and Deqing Tang and Ben Liu}, doi = {10.1002/anie.202423112}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mesoporous cu nanoplates with exposed cu+ sites for efficient electrocatalytic transfer semi-hydrogenation of alkynes}, volume = {64}, year = {2025}, }
• (2025). Efficient alkaline-free electrooxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid using electrochemically-charged NixCo1-x(OH)2 as a redox mediator. ANGEW, 64(13), e202423109. (www)

  @article{ , abstract = {Converting biomass-derived molecules like 5-hydroxymethylfurfural (HMF) into value-added products alongside hydrogen production using renewable energy offers significant opportunities for sustainable chemical and energy production. Yet, HMF electrooxidation requires strong alkaline conditions and membranes for efficient conversion. These harsh conditions destabilize HMF, leading to humin formation and reduced product purity, meanwhile membranes increase costs. Addressing these challenges, we introduce a two-step, decoupling system that operates without strong alkaline conditions and eliminates the need of membranes. In this system, nickel-cobalt hydroxides serve as effective redox mediators, driving HMF oxidation in pure water. The experimental results showed that Ni 0.85 Co 0.15 OOH effectively promotes the dehydrogenation of substrate and achieves a highly efficient oxidation of HMF in pure water, with the selectivity of product 2,5-furandicarboxylic acid (FDCA) approaching 100 %. This system has been expanded to oxidize various substrates, achieving yields exceeding 92 % for the corresponding acids of functionalized compounds such as furfuryl alcohol, furfural, benzyl alcohol, and benzaldehyde. By replacing fixed electrodes with flow electrodes, the scalability of decoupling strategy was evaluated for the harvesting of pure solid FDCA, highlighting the broad prospects in practical applications.}, archive = {J_ANGEW}, author = {Jifang Zhang and Yue Shen and Zenglong Wu and Xinyuan Zhang and Jian Kang and Yijin Wu and Shengbo Zhang and Shan Chen and Guozhong Wang and Haimin Zhang and Huajie Yin and Huijun Zhao}, doi = {10.1002/anie.202423109}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423109}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient alkaline-free electrooxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid using electrochemically-charged NixCo1-x(OH)2 as a redox mediator}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-localization transfer regulation in 3D COFs enhances photocatalytic acetylene semi-hydrogenation to ethylene. ANGEW, 64(13), e202423091. (www)

  @article{ , abstract = {In this work, a series of new crystalline three-dimensional covalent organic frameworks (3D COFs) based on [8+4] construction was designed and successfully realized efficient photocatalytic acetylene (C 2 H 2 ) hydrogenation to ethylene (C 2 H 4 ). By regulating the hydrogen-localization transfer effect in these 3D COFs, the Cz−Co−COF−H containing cobalt glyoximate active centers exhibited excellent C 2 H 2 -to-C 2 H 4 performance, with an average C 2 H 4 yield of 1755.33 μmol g −1 h −1 in pure C 2 H 2 , also showed near 100 % conversion of C 2 H 2 in 1 % C 2 H 2 contained crude C 2 H 4 mixtures (industry-relevant conditions), and finally obtain polymer grade C 2 H 4 . In contrast, the Cz−Co−COF−BF 2 only showed one fifth activity due to lack of hydrogen-localization transfer. The density functional theory (DFT), projected density of states (PDOS) and molecular dynamics “slow-growth” kinetic calculations based on precise 3D COF structures confirmed that the rapid hydrogen species transfer, enhanced water dissociation and suitable C 2 H 2 adsorption in COFs jointly contributed efficient photocatalytic acetylene hydrogenation (PAH). This work provides new opportunity towards rational design and development of crystalline photocatalysts for C 2 H 2 hydrogenation.}, archive = {J_ANGEW}, author = {Pei Huang and Ming-Yi Yang and Shuai-Bing Zhang and Ze-Hui Li and Han Zhang and Si-Miao Wang and Yan-Yu Peng and Mi Zhang and Shun-Li Li and Meng Lu and Ya-Qian Lan}, doi = {10.1002/anie.202423091}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423091}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-localization transfer regulation in 3D COFs enhances photocatalytic acetylene semi-hydrogenation to ethylene}, volume = {64}, year = {2025}, }
• (2025). Discrete hybrid vanadium-oxo cluster as a targeted tool for selective protein oxidative modifications and cleavage. ANGEW, 64(13), e202423078. (www)

  @article{ , abstract = {Understanding the impact of oxidative modification on protein structure and functions is essential for developing therapeutic strategies to combat macromolecular damage and cell death. However, selectively inducing oxidative modifications in proteins under physiological conditions remains challenging. Herein we demonstrate that [V 6 O 13 {(OCH 2 ) 3 CCH 2 OH} 2 ] 2− (V 6 -OH) hybrid metal-oxo cluster can be used for selective protein oxidative cleavage and modifications. We present the first example of a protein-bound hybrid vanadate cluster, where its interactions with protein surfaces and the redox activity of vanadium enable selective oxidative modifications. Single Crystal X-ray Diffraction (SC-XRD) of the V 6 -OH and hen egg white lysozyme (HEWL) complex revealed that the binding is dictated both by the inorganic core and the organic ligands attached to it. Selective oxidation or cleavage of HEWL occurs under physiological conditions by producing reactive oxygen species (ROS) in presence of ascorbate (Asc) as a reducing agent. The outcome of the oxidative reaction can be tuned by varying the concentration of V 6 -OH to result either in selective oxidation of the amino acid side chains or peptide bond cleavage. LC–MS and crystallography revealed that oxidative modifications were mainly concentrated near the cluster binding sites, providing spatial control of ROS production. This study advances our understanding of vanadium's role in biological systems and demonstrates the potential of hybrid metal-oxo clusters in protein modification.}, archive = {J_ANGEW}, author = {Mhamad Aly Moussawi and Francisco de Azambuja and Tatjana N. Parac-Vogt}, doi = {10.1002/anie.202423078}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423078}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Discrete hybrid vanadium-oxo cluster as a targeted tool for selective protein oxidative modifications and cleavage}, volume = {64}, year = {2025}, }
• (2025). Competitive coordination and dual interphase regulation of MOF-modified solid-state polymer electrolytes for high-performance sodium metal batteries. ANGEW, 64(13), e202423075. (www)

  @article{ , abstract = {Solid-state polymer electrolytes (SPEs) have emerged as prominent candidates for solid-state sodium metal batteries (SMBs) due to their enhanced flexibility and reduced interfacial resistance. However, their performance is limited by poor Na + conductivity at room temperature, disordered ion transport properties and unstable interfaces. Herein, a three-dimensional (3D) interconnected copper metal–organic framework (Cu-MOF) on polyacrylonitrile (PAN) fibers is introduced into polyethylene oxide (PEO)-based SPEs to construct a composite electrolyte (PPNM). The open metal sites (OMS) of the Cu-MOF compete with Na + , effectively coordinating with TFSI − anions and oxygen atoms in PEO, thereby reducing concentration polarization, weakening the Na + −O binding strength and facilitating Na + migration. By harnessing the multifunctional properties of Cu-MOF and PAN, the PPNM electrolyte exhibits superior ionic conductivity (1.03×10 −4 S cm −1 ) and a high Na + transference number (0.58) at room temperature. The strong anchoring of TFSI − anions by Cu-MOF promotes the formation of inorganic-rich (NaF and Na 3 N) cathode electrolyte interphase (CEI) and solid electrolyte interphase (SEI) layers, enhancing dual interfacial stability. The Na 3 V 2 (PO 4 ) 3 @C/PPNM/Na full cells realize robust cycling performance for 2000 cycles at 200 mA g −1 . This work provides a facile strategy for regulating the Na + coordination state and interphase engineering in solid-state SMBs.}, archive = {J_ANGEW}, author = {Wenyue Tian and Guangliang Lin and Shaohui Yuan and Ting Jin and Qinglun Wang and Lifang Jiao}, doi = {10.1002/anie.202423075}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423075}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Competitive coordination and dual interphase regulation of MOF-modified solid-state polymer electrolytes for high-performance sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Vacancy-activated B-doping for efficient 2e− oxygen reduction through suppressing H2O2 decomposition at high overpotential. ANGEW, 64(13), e202423056. (www)

  @article{ , abstract = {The production of hydrogen peroxide (H 2 O 2 ) through two-electron oxygen reduction reaction (2e − ORR) has emerged as a more environmentally friendly alternative to the traditional anthraquinone method. Although oxidized carbon catalysts have intensive developed due to their high selectivity and activity, the yield and conversion rate of H 2 O 2 under high overpotential still limited. The produced H 2 O 2 was rapidly consumed by the increased intensity of H 2 O 2 reduction, which could ascribe to decomposition of peroxide radicals under high voltage in the carbon catalyst. To overcome this issue, a B doped carbon have been developed to catalyze 2e − ORR with high efficient through suppressing H 2 O 2 decomposition at high potential. Thus, thermal reducing of oxygen containing groups (OCGs) on graphite could construct defects and vacancies, which in situ convert to B−C x subunits on the edge of graphene sheets. The introduction of B−C x effectively prevented the decomposition of the *O−O bond and provided suitable adsorption capacity for *OOH, achieving excellent selectivity for the 2e − ORR across a wide voltage range. Finally, a remarkable H 2 O 2 yield of 7.91 mmol cm −2 h −1 was delivered at an industrial current density of 600 mA cm −2 , which could provide “green” pathway for scale-upable synthesis H 2 O 2 .}, archive = {J_ANGEW}, author = {Wangyang Cui and Zhiyuan Zhen and Yuanyuan Sun and Xiaofeng Liu and Jinhui Chen and Sijia Liu and Hao Ren and Yan Lin and Mingbo Wu and Zhongtao Li}, doi = {10.1002/anie.202423056}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202423056}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vacancy-activated B-doping for efficient 2e− oxygen reduction through suppressing H2O2 decomposition at high overpotential}, volume = {64}, year = {2025}, }
• (2025). Formamidine as an easy-on and easy-off linker for reversible crosslinking of two alkyl amines in peptide stapling and conjugation. ANGEW, 64(13), e202422844. (www)

  @article{ , abstract = {Amino groups are abundant in both natural and synthetic molecules, offering highly accessible sites for modifying native biorelevant molecules. Despite significant progress with more reactive thiol groups, methods for ligating two amino groups with reversible linkers for bioconjugation applications remain elusive. Herein, we report the use of oxidative decarboxylative condensation of glyoxylic acid to crosslink or ligate two alkyl amines via a compact formamidine linkage, applicable in both intra- and intermolecular contexts. This linking chemistry exhibits unique hetero-coupling selectivity between primary and secondary alkyl amines. Although the formamidine linkage is stable under pH-neutral buffers and acidic conditions, it can be readily cleaved with ethylenediamine or hydrazine under mild conditions in alcohol solvents or aqueous media, fully restoring the amino groups. This study introduces a rare ‘easy-on and easy-off’ strategy for connecting two native amines in peptide stapling and biomolecule conjugation.}, archive = {J_ANGEW}, author = {Xin Chu and Zhang Zhang and Xiaoxi Xu and Wenli Guan and Shuai Jiang and Shaokun Cai and Tianxi Yang and Gang He and Chuanzheng Zhou and Gong Chen}, doi = {10.1002/anie.202422844}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422844}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formamidine as an easy-on and easy-off linker for reversible crosslinking of two alkyl amines in peptide stapling and conjugation}, volume = {64}, year = {2025}, }
• (2025). A zero-gap electrolyzer enables supporting electrolyte-free seawater splitting for energy-saving hydrogen production. ANGEW, 64(13), e202422840. (www)

  @article{ , abstract = {Membrane-assisted direct seawater splitting (DSS) technologies are actively studied as a promising route to produce green hydrogen (H 2 ), whereas the indispensable use of supporting electrolytes that help to extract water and provide electrochemically-accelerated reaction media results in a severe energy penalty, consuming up to 12.5 % of energy input when using a typical KOH electrolyte. We bypass this issue by designing a zero-gap electrolyzer configuration based on the integration of cation exchange membrane and bipolar membrane assemblies, which protects stable DSS operation against the precipitates and corrosion in the absence of additional supporting electrolytes. The heterolytic water dissociation function of the bipolar membrane in situ creates an asymmetric acidic-alkaline environment, kinetically facilitating H 2 and O 2 evolution reactions. When working in natural seawater without any chemical inputs, this zero-gap electrolyzer sustains nearly 100 % Faradaic efficiency toward H 2 for 120 h at a current density of 100 mA cm −2 . With the high-integrity merit, our electrolyzer can be facilely scaled up into practical cell stacks with significantly increased active area and promising prospects for volume/space-sensitive application scenarios. This electrolyzer concept opens an underexplored design space for energy-saving H 2 production from low-grade saline water sources, being complementary to, and potentially competitive with the pre-purification Schemes.}, archive = {J_ANGEW}, author = {Yongwen Ren and Faying Fan and Shu Zhang and Zhaohan Liu and Yaojian Zhang and Fu Sun and Jiedong Li and Lin Chen and Zhe Wang and Jingwen Zhao and Jieshan Qiu and Guanglei Cui}, doi = {10.1002/anie.202422840}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422840}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A zero-gap electrolyzer enables supporting electrolyte-free seawater splitting for energy-saving hydrogen production}, volume = {64}, year = {2025}, }
• (2025). On the role of hydrogen migrations in the taxadiene system. ANGEW, 64(13), e202422788. (www)

  @article{ , abstract = {Taxa-4,11-diene is made by the taxa-4,11-diene synthase (TxS) from Taxus brevifolia . The unique reactivity of the taxane system is characterised by long distance hydrogen migrations in the biosynthesis. This study demonstrates that selective long range hydrogen migrations also play a role in the high energy process of the EI-MS fragmentation of taxa-4,11-diene. A TxS enzyme variant was generated that produces cyclophomactene, a compound that is formed through a concerted process involving a long range proton shift and a ring closure that can also be described as the addition of a methylcarbinyl cation to an olefin. Based on a previous computational study the cyclisation mechanism towards taxa-4,11-diene was suggested to involve two long distance proton migrations instead of one direct transfer. A substrate analog with a shifted double bond was converted with TxS to obtain experimental evidence for this proposal.}, archive = {J_ANGEW}, author = {Heng Li and Bernd Goldfuss and Jeroen S. Dickschat}, doi = {10.1002/anie.202422788}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422788}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On the role of hydrogen migrations in the taxadiene system}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic dehalogenation of aryl halides mediated by the flexible Metal–Organic framework MIL-53(Cr). ANGEW, 64(13), e202422776. (www)

  @article{ , abstract = {The catalytic potential of flexible metal–organic frameworks (MOFs) remains underexplored, particularly in liquid-phase reactions. This study employs MIL-53(Cr), a prototypical “breathing” MOF capable of structural adaptation via pore size modulation, as a photocatalyst for the dehalogenation of aryl halides. Powder X-ray diffraction and Pair Distribution Function analyses reveal that organic solvents influence pore opening, while substrates and products dynamically adjust the framework configuration during catalysis. This structural flexibility enables precise tuning of photocatalytic efficiency via solvent-mediated control of the pore aperture. The results demonstrate that the dynamic behavior of MIL-53(Cr) facilitates enhanced catalytic activity and selectivity, advancing the application of flexible MOFs as tunable, enzyme-mimicking catalysts. These findings pave the way for the rational design of next-generation flexible photocatalysts.}, archive = {J_ANGEW}, author = {Tian Luo and Henrik S. Jeppesen and Alexander Schoekel and Nadine Bönisch and Fei Xu and Rong Zhuang and Qiang Huang and Irena Senkovska and Volodymyr Bon and Thomas Heine and Agnieszka Kuc and Stefan Kaskel}, doi = {10.1002/anie.202422776}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic dehalogenation of aryl halides mediated by the flexible Metal–Organic framework MIL-53(Cr)}, volume = {64}, year = {2025}, }
• (2025). Expediting glycospace exploration: Therapeutic glycans via automated synthesis. ANGEW, 64(13), e202422766. (www)

  @article{ , abstract = {Glycans regulate a vast spectrum of disease-related processes, yet effectively leveraging these important mediators in a therapeutic context remains a frontier in contemporary medicine. Unlike many other classes of clinically important biopolymers, carbohydrates derive from discrete biosynthetic pathways and are not produced directly from genes. The conspicuous absence of a biological blueprint to achieve amplification creates a persistent challenge in obtaining well-defined glycostructures for therapeutic translation. Isolating purified sugars from biological sources is not without challenge, rendering synthetic organic chemistry the nexus of this advancing field. Chemical synthesis has proven to be an unfaltering pillar in the production of complex glycans, but laborious syntheses coupled with purification challenges frequently introduce reproducibility issues. In an effort to reconcile these preparative challenges with the societal importance of glycans, automated glycan synthesis was conceptualised at the start of the 21st century. This rapidly expanding, multifaceted field of scientific endeavor has effectively merged synthetic chemistry with technology and engineering to expedite the precision synthesis of target glycans. This minireview describes the structural diversity and function of glycans generated by automated glycan synthesis platforms over the last five years. The translational impact of these advances is discussed together with current limitations and future directions.}, archive = {J_ANGEW}, author = {James Suri and Ryan Gilmour}, doi = {10.1002/anie.202422766}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422766}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expediting glycospace exploration: Therapeutic glycans via automated synthesis}, volume = {64}, year = {2025}, }
• (2025). Optimizing acidic oxygen evolution reaction via modulation doping in van der waals layered iridium oxide. ANGEW, 64(13), e202422740. (www)

  @article{ , abstract = {Anodic oxygen evolution reaction (OER) exhibits a sluggish four-electron transfer process, necessitating catalysts with exceptional catalytic activity to enhance its kinetic rate. Van der Waals layered oxides are ideal materials for catalyst design, yet its stability for acidic OER remains large obstacle. Doping provides a crucial way to improve the activity and stability simultaneously. However, doping in Van der Waals layered oxides remains a great challenge since it easily leads to lattice distortion or even the crystal structure damage. In this work, we successfully doping acid-resistant niobium (Nb) into Van der Waals layered edge-shared 1T phase iridium oxide (1 T-IrO 2 ) via alkali-assisted thermal method. 1 T-IrO 2 with a 5 % Nb doping (Nb 0.05 Ir 0.95 O 2 ) only required an overpotential of 191 mV to achieve a current density of 10 mA cm −2 in 0.5 M H 2 SO 4 , 56 mV lower than that of 1T-IrO 2 . When applied in proton exchange membrane water electrolyzer, Nb 0.05 Ir 0.95 O 2 show stable operation at a high current density of 1.2 A cm −2 for over 50 days. Density functional theory calculation reveals that doping Nb changes the potential-determining step from the *OOH deprotonation process in 1 T-IrO 2 to the *O−OH coupling process in Nb 0.05 Ir 0.95 O 2 .}, archive = {J_ANGEW}, author = {Jia Ke and Wenxiang Zhu and Yujin Ji and Jinxin Chen and Chenchen Li and Yue Wang and Qun Wang and Wei-Hsiang Huang and Zhiwei Hu and Youyong Li and Qi Shao and Jianmei Lu}, doi = {10.1002/anie.202422740}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422740}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimizing acidic oxygen evolution reaction via modulation doping in van der waals layered iridium oxide}, volume = {64}, year = {2025}, }
• (2025). Reductive carbon materials: Tailoring chemistry and electronic properties to improve sodium-ion batteries. ANGEW, 64(13), e202422714. (www)

  @article{ , abstract = {The development of versatile strategies for preparing functional carbon materials is essential for advancing a wide range of applications in materials science. Precursor design plays a pivotal role in governing the chemistry and structure of carbon materials for target applications. In this work, we report the synthesis of Meldrum's acid derivatives through Knoevenagel condensation with aromatic heterocycles such as pyrrole, furan, and thiophene, which serve as precursors for carbonaceous materials with tailored chemical and electronic properties. The thermal condensation of these precursors proceeds via highly reactive, electron-rich ketene intermediates, playing a crucial role in the formation of the carbon materials. The resulting heteroatom-doped carbon materials exhibit tunable chemical, physico-chemical, and structural properties, which we have correlated with their energy storage performances. Eventually, we deem this strategy of high interest for designing high-performance carbonaceous materials with tunable properties for a broad range of applications, from electrochemical energy storage to conversion, water filtration, environmental remediation, and beyond.}, archive = {J_ANGEW}, author = {Elif Begüm Yılmaz and Enis Oğuzhan Eren and Tim Horner and Zihan Song and Yasaman Sheidaei and Inke Siewert and Evgeny Senokos and Paolo Giusto}, doi = {10.1002/anie.202422714}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422714}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reductive carbon materials: Tailoring chemistry and electronic properties to improve sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). An anionic mesoionic carbene (anMIC) and its transformation to metallo MIC-boranes: Synthesis and properties. ANGEW, 64(13), e202422702. (www)

  @article{ , abstract = {Neutral mesoionic carbenes (MICs) based on a 1,2,3-triazole core have had a strong impact on various branches of chemistry such as homogeneous catalysis, electrocatalysis, and photochemistry/photophysics. We present here the first general synthesis of anionic mesoionic carbenes (anMICs, 2 ) based on a 1,2,3-triazole core and a borate backbone. The free anMIC is stable in solution under an inert atmosphere at low temperatures, and can be stored for several weeks. Analysis of donor properties shows that these anMICs are extremely strong σ-donors, bypassing the donor properties of strong donors such as MICs, NHCs, anionic NHCs and N-heterocyclic olefins. The room temperature conversion of the free anMICs leads to three equally interesting compound classes: an amide-coordinated borane based on a MIC-borane backbone ( 2BR 3 ), a polymeric triazolide ( 1Li ) and an amide-coordinated metallo-MIC-borane. The metallo-MIC-borane ( 3Li ) is an interesting precursor for the synthesis of further amide-coordinated MIC-borane compounds. Quantum chemical calculations have been used to elucidate the mechanism of transformation of the anMICs. We thus introduce three new categories of mesoionic compounds here with potential for different branches of chemistry and beyond.}, archive = {J_ANGEW}, author = {Richard Rudolf and Andrej Todorovski and Vera Lederer and Nicolás I. Neuman and Hartmut Schubert and Biprajit Sarkar}, doi = {10.1002/anie.202422702}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An anionic mesoionic carbene (anMIC) and its transformation to metallo MIC-boranes: Synthesis and properties}, volume = {64}, year = {2025}, }
• (2025). Amide-directed highly enantioselective hydrogenation of diverse acyclic multisubstituted alkenes under mild conditions. ANGEW, 64(13), e202422698. (www)

  @article{ , abstract = {Enantioselective hydrogenation of tetrasubstituted alkenes to form 1,2-contiguous stereocenters is a particularly appealing but highly challenging transformation in asymmetric catalysis. Despite the notable progress achieved in enantioselective hydrogenation over the past decades, enantioselective hydrogenation of all-carbon tetrasubstituted alkenes containing multiple alkyl groups remains an unsolved challenge. Here, we report a rhodium-catalyzed highly diastereo- and enantioselective hydrogenation of diverse acyclic multisubstituted alkenes under mild conditions. The coordination assistance of the amide group to the metal center generates a highly active catalyst that effectively overcomes the low reactivity of substrates and precisely controls the stereoselectivity. The generality of this catalyst system is exemplified by its efficacy across at least three types of alkenes including β,γ-unsaturated amides, α,β-unsaturated amides, and enamides.}, archive = {J_ANGEW}, author = {Hou-Xiang Lu and Shou-Lin Lu and Bi-Jie Li}, doi = {10.1002/anie.202422698}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amide-directed highly enantioselective hydrogenation of diverse acyclic multisubstituted alkenes under mild conditions}, volume = {64}, year = {2025}, }
• (2025). Li+ quasi-grotthuss topochemistry transport enables direct regeneration of spent lithium-ion battery cathodes. ANGEW, 64(13), e202422610. (www)

  @article{ , abstract = {Direct regeneration of spent lithium-ion batteries offers economic benefits and a reduced CO 2 footprint. Surface prelithiation, particularly through the molten salt method, is critical in enhancing spent cathode repair during high-temperature annealing. However, the sluggish Li + transport kinetics, which predominantly relies on thermally driven processes in the traditional molten salt methods, limit the prelithiation efficiency and regeneration of spent cathodes. Here, we introduce a special molecular configuration (benzoate) into molten salts that facilitates rapid Li + transport to the surface of LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM) via a quasi-Grotthuss topochemistry mechanism. This approach effectively avoids the phase transitions that could adversely degrade the electrochemical performance due to insufficient lithiation during the repair process. Computational and experimental analyses reveal that the system enables fast Li + migration through the topological hopping of benzoate in organic lithium salt, rather than relying solely on thermally driven diffusion, thereby significantly improving the prelithiation and repair efficiency of spent NCM cathodes. Benefiting from the quasi-Grotthuss Li + topochemistry transport, the degraded structure and Li vacancies in the spent cathode are effectively eliminated, yieding the regenerated cathode with good cycling stability comparable to commercial counterparts. The proposed Li + transport mechanism presents a promising route for the efficient and sustainable regeneration of spent cathodes.}, archive = {J_ANGEW}, author = {Yujia He and Kai Jia and Zhihong Piao and Zhenjiang Cao and Mengtian Zhang and Pengfei Li and Zhichao Li and Zhiyuan Jiang and Guorui Yang and Huan Xi and Guangmin Zhou and Wei Tang and Zhiguo Qu and R. Vasant Kumar and Shujiang Ding and Kai Xi}, doi = {10.1002/anie.202422610}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422610}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Li+ quasi-grotthuss topochemistry transport enables direct regeneration of spent lithium-ion battery cathodes}, volume = {64}, year = {2025}, }
• (2025). A self-supporting flexible electrode for tracking and reversible quantification of mg2+ and ca2+ in the brains of freely behaving animal. ANGEW, 64(13), e202422602. (www)

  @article{ , abstract = {Monitoring dynamic neurochemical signals in the brain of free-moving animals remains great challenging in biocompatibility and direct implantation capability of current electrodes. Here we created a self-supporting polymer-based flexible microelectrode (rGPF) with sufficient bending stiffness for direct brain implantation without extra devices, but demonstrating low Young's modulus with remarkable biocompatibility and minimal position shifts. Meanwhile, screening by density functional theory (DFT) calculation, we designed and synthesized specific ligands targeting Mg 2+ and Ca 2+ , and constructed Mg−E and Ca−E sensors with high selectivity, good reversibility, and fast response time, successfully monitoring Mg 2+ and Ca 2+ in vivo up to 90 days. Using this powerful tool, we discovered for the first time that, during the 4-aminopyridine-induced seizure in the live brain, extracellular Mg 2+ inhibited Ca 2+ influx. Moreover, the timing of initial changes in Mg 2+ and Ca 2+ levels during seizures aligned with neural pathways, which had not been previously reported.}, archive = {J_ANGEW}, author = {Shidi Wang and Yuandong Liu and Lin-chun Peng and Wei Duan and Yousheng Shu and Yang Tian}, doi = {10.1002/anie.202422602}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A self-supporting flexible electrode for tracking and reversible quantification of mg2+ and ca2+ in the brains of freely behaving animal}, volume = {64}, year = {2025}, }
• (2025). A malleable collagen-mimic that undergoes moisture-induced hardening for gluing hydrophilic surfaces. ANGEW, 64(13), e202422593. (www)

  @article{ , abstract = {A collagen-inspired helical protein-mimic has been synthesized via topochemical polymerization of a designed tripeptide monomer. In the monomer crystal, molecules arrange in a head-to-tail manner, forming supramolecular helices. The azide and alkyne of adjacent molecules in the supramolecular helix are proximally preorganized in a ready-to-react arrangement. On heating, the monomer crystals undergo regiospecific single-crystal-to-single-crystal azide-alkyne cycloaddition polymerization, yielding triazolyl- polypeptide. Polymerization softens the crystals, making the polymer malleable and mouldable. The polymer grains absorb moisture and form agglomerates through water-bridged adhesion, which hardens over time. The weight-bearing capacity of a mould made from this polymer increased by 50-fold due to moisture-induced hardening. We have demonstrated that this collagen-mimic can glue both biological specimens such as wood and bone and synthetic materials such as glass and paper. In vitro studies established the biocompatibility, making it an attractive bioinspired material for potential application as a bioadhesive.}, archive = {J_ANGEW}, author = {Rishika Rai and Divina Xavier and Sourav Pathak and Francis B. Fernandez and Manoj Komath and Kana M. Sureshan}, doi = {10.1002/anie.202422593}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A malleable collagen-mimic that undergoes moisture-induced hardening for gluing hydrophilic surfaces}, volume = {64}, year = {2025}, }
• (2025). Intensifying interfacial reverse hydrogen spillover for boosted electrocatalytic nitrate reduction to ammonia. ANGEW, 64(13), e202422585. (www)

  @article{ , abstract = {Rational regulation of active hydrogen (*H) behavior is crucial for advancing electrocatalytic nitrate reduction reaction (NO 3 RR) to ammonia (NH 3 ), yet in-depth understanding of the *H generation, transfer, and utilization remains ambiguous, and explorations for *H dynamic optimization are urgently needed. Herein we engineer a Ni 3 N nanosheet array intimately decorated with Cu nanoclusters (NF/Ni 3 N−Cu) for remarkably boosted NO 3 RR. From comprehensive experimental and theoretical investigations, the Ni 3 N moieties favors water dissociation to generate *H, and then *H can rapidly transfer to the Cu via unique reverse hydrogen spillover mediating interfacial Ni−N−Cu bridge bond, thus increasing *H coverage on the Cu site for subsequent deoxygenation/hydrogenation. More impressively, such intriguing reverse hydrogen spillover effect can be further strengthened via elegant engineering of the Ni 3 N/Cu heterointerface with more intimate contact. Consequently, the NF/Ni 3 N−Cu with Cu nanoclusters intimate anchoring presents record NH 3 yield rate of 1.19 mmol h −1 cm −2 and Faradaic efficiency of 98.7 % at −0.3 V vs. RHE, being on par with the state-of-the-art ones. Additionally, with NF/Ni 3 N−Cu as the cathode, a high-performing Zn−NO 3 − battery can be assembled. This contribution illuminates a novel pathway to optimize *H behavior via distinct reverse hydrogen spillover for promoted NO 3 RR and other hydrogenation reactions.}, archive = {J_ANGEW}, author = {Xiao Ouyang and Wei Qiao and Yuting Yang and Baojuan Xi and Yu Yu and Yilu Wu and Jingyun Fang and Ping Li and Shenglin Xiong}, doi = {10.1002/anie.202422585}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422585}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intensifying interfacial reverse hydrogen spillover for boosted electrocatalytic nitrate reduction to ammonia}, volume = {64}, year = {2025}, }
• (2025). Mastering the copolymerization behavior of ethyl cyanoacrylate as gel polymer electrolyte for lithium-metal battery application. ANGEW, 64(13), e202422510. (www)

  @article{ , abstract = {Polymers with strong electron-withdrawing groups (e.g., cyano-containing polymers) are attractive for a wide range of applications due to their high dielectric constant and outstanding electrochemical stability. However, the polymerization of such monomers is difficult to control with trace of water affording instant reactions, and copolymerization with other monomers without using strong acid is even more challenging. The present study demonstrates a facile approach enabling efficient and controllable copolymerization of ethyl cyanoacrylate (ECA) without adding undesired additives, achieving mechanically robust and high ion-conduction gel polymer electrolyte (GPE) for safe and long cycle-life lithium-metal batteries (LMBs). The incorporated dual-lithium salts, i.e., lithium difluoro(oxalato)borate (LiDFOB) and lithium bis(trifluoromethanesulphonyl)imide (LiTFSI) not only facilitate radical polymerization of ECA monomers by suppressing their anionic polymerization, but also promote the formation of high-ionic conducting GPE. The incorporated methyl methacrylate (MMA) monomer accelerates the radical polymerization of ECA (confirmed by DFT calculations), achieving controlled copolymerization of ECA-based copolymers. The mechanically robust polymer network made by the ECA copolymer enables LMBs with both LFP cathodes and high-voltage LCO cathodes (4.5 V) operatable at different temperatures with ultra-long cycle life at 1 C (capacity retention of 81.1 % and 83.8 %, respectively, over 1000 cycles).}, archive = {J_ANGEW}, author = {Weixing Min and Lengwan Li and Mingli Wang and Shuaijiang Ma and Hao Feng and Weirong Wang and Hang Ding and Tianhui Cheng and Zhenxi Li and Tomonori Saito and Huabin Yang and Peng-Fei Cao}, doi = {10.1002/anie.202422510}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422510}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mastering the copolymerization behavior of ethyl cyanoacrylate as gel polymer electrolyte for lithium-metal battery application}, volume = {64}, year = {2025}, }
• (2025). Isolation and structure elucidation of the heterocumulene anions [NCC-l]− (L=CO, CS, n2). ANGEW, 64(13), e202422496. (www)

  @article{ , abstract = {Cumulenes are molecules characterized by a series of consecutive double bonds. They serve as important reagents and intermediates in the synthesis of polymers and a wide variety of functionalized compounds, including various heterocycles. Understanding the properties of cumulenes and developing synthetic routes to these often highly reactive species is essential for unlocking new applications. Here, we report the synthesis and isolation of the cyanodiazomethanide [NCCNN] − and cyanothioketenyl anion [NCCCS] − . These 5-atomic anions exhibit unexpected stabilities but distinct structural differences. Despite the explosive nature of diazoacetonitrile, the [NCCNN] − anion was sufficiently stable at 0 °C to allow for first reactivity studies and its structure elucidation revealing a bent structure. The thioketenyl anion is stable at room-temperature and can be accessed from the cyanoketenyl anion [NCCCO] − via a [2+2] cycloaddition and cycloreversion sequence with COS elimination. Comparative structural, spectroscopic and computational studies including those on the cyanoketenyl anion [NCCCO] − , demonstrate that the degree of bending of these heterocumulene anions [NCC-L] − can be explained by a transition in the bonding situation from a cumulene structure to an anionic carbone, with the strongly π accepting CS ligand leading to a linear structure of the thioketenyl anion.}, archive = {J_ANGEW}, author = {Quentin Le Dé and Yihao Zhang and Lili Zhao and Felix Krischer and Kai-Stephan Feichtner and Gernot Frenking and Viktoria H. Gessner}, doi = {10.1002/anie.202422496}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isolation and structure elucidation of the heterocumulene anions [NCC-l]− (L=CO, CS, n2)}, volume = {64}, year = {2025}, }
• (2025). Multiple near-infrared chromisms of a heteromerous overcrowded ethylene with large permanent dipole moment. ANGEW, 64(13), e202422448. (www)

  @article{ , abstract = {An overcrowded ethylene composed of electron-donating anion, naphthoxide, and electron-accepting cation, acridinium, has been synthesized. It is in equilibrium between a folded conformer having a smaller permanent dipole moment with visible light absorption and a twisted conformer having a larger permanent dipole moment with NIR light absorption. The overcrowded ethylene shows multiple NIR chromisms, such as solvatochromism, thermochromism, mechanochromism, vapochromism, halochromism, and amphoteric electrochromisms, which are caused by the conformational change between folded and twisted conformers or by controlling the energy difference between the HOMO of the donor moiety and the LUMO of the acceptor moiety. The small difference between the HOMO energy level of naphthoxide moiety and the LUMO energy level of acridinium moiety, and their weak interaction are crucial for NIR absorption and large dipole moment in the twisted conformer. The drastic change in the ratio of folded and twisted conformers by changing the polarity of solvents, the detection of CO 2 , and the disappearance of NIR absorption by electrochemical oxidation and reduction are noteworthy for this new type of organic dye.}, archive = {J_ANGEW}, author = {Akihiro Shimizu and Yuki Misaki and Chihiro Kondo and Ayane Kayama and Takashi Hirose and Hiroyasu Sato and Ryo Shintani}, doi = {10.1002/anie.202422448}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422448}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple near-infrared chromisms of a heteromerous overcrowded ethylene with large permanent dipole moment}, volume = {64}, year = {2025}, }
• (2025). Cell-active, arginine-targeting irreversible covalent inhibitors for non-kinases and kinases. ANGEW, 64(13), e202422372. (www)

  @article{ , abstract = {Targeted covalent inhibitors (TCIs) play an essential role in the fields of kinase research and drug discovery. TCI strategies to target more common amino acid side-chains have yet to be demonstrated. Targeting other amino acids would also expand the pharmaceutical industry‘s toolbox for targeting other tough-to-drug proteins. We report herein a glyoxal-based, arginine-reactive strategy to generate potent and selective small-molecule TCIs of Mcl-1 (an important anti-apoptotic protein) by selectively targeting the conserved arginine (R263) in the protein. We further validated the generality of this strategy by developing glyoxal-based, irreversible covalent inhibitors of AURKA (a cancer-related kinase) that showed exclusive reactivity with a solvent-exposed arginine (R220) of this enzyme. We showed the resulting compounds were potent, selective and cell-active, capable of covalently engaging endogenous AURKA in MV-4–11 cells with long residence time. Finally, we showed the potential application of glyoxal-based TCIs in targeting an acquired drug-resistance mutant of ALK kinase (G1202R).}, archive = {J_ANGEW}, author = {Peng Chen and Lu Wang and Xuan Wang and Jie Sun and Fengfei Miao and Zuqin Wang and Fang Yang and Menghua Xiang and Mingxi Gu and Shengrong Li and Jianzhong Zhang and Peiyan Yuan and Xiaoyun Lu and Zhi-Min Zhang and Liqian Gao and Shao Q. Yao}, doi = {10.1002/anie.202422372}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422372}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cell-active, arginine-targeting irreversible covalent inhibitors for non-kinases and kinases}, volume = {64}, year = {2025}, }
• (2025). Multicomponent polymerization toward Poly(BODIPY-sulfonamide)s as unique SO2 generators for sonodynamic and gas combination therapy. ANGEW, 64(13), e202422362. (www)

  @article{ , abstract = {In this work, a multicomponent polymerization (MCP) approach involving bipyrroles, sulfonyl azides, and diynes was developed to afford a library of poly(bipyrrole-sulfonylimide)s (PPSIs) in high yields and molecular weights, which were further modified to form unique sulfur dioxide (SO 2 ) generators. Bipyrroles served as carbon-based nucleophiles to undergo Cu-catalyzed C−C coupling during the MCP. Upon post-MCP modification by transforming the bipyrrole unit to boron dipyrromethene (BODIPY) and the sulfonylimide moiety to sulfonamide, poly(BODIPY-sulfonamide)s (PBSAs) were obtained as potent anticancer therapeutic agents. This study disclosed the decomposition and SO 2 -releasing ability of PBSAs under ultrasound (US) irradiation. Furthermore, one of these polymers having a reactive oxygen species-cleavable thioketal linker was modified with triethylene glycol chains to give PBSA-EG , which was further studied for in vitro and in vivo US-induced anti-cancer therapy. Upon tail veil administration of PBSA-EG nanoparticles into tumor-bearing mice followed by US irradiation, remarkable tumor suppression was observed. This study demonstrates that the innovative and efficient MCP method can construct polymers bearing the BODIPY-sulfonamide moieties, which show a great potential as safe and potent materials for combined gas and sonodynamic therapy against cancer.}, archive = {J_ANGEW}, author = {Shuxin Liu and Juan Li and Aiguo Wang and Dennis K. P. Ng and Nan Zheng}, doi = {10.1002/anie.202422362}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422362}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multicomponent polymerization toward Poly(BODIPY-sulfonamide)s as unique SO2 generators for sonodynamic and gas combination therapy}, volume = {64}, year = {2025}, }
• (2025). General and versatile nanoarchitectonics for amino acid-based glasses via co-assembly of organic counterions. ANGEW, 64(13), e202422272. (www)

  @article{ , abstract = {Amino acid-based biomolecular glasses represent an emerging material to meet the demand for sustainable development. However, most amino acids are difficult to vitrify due to their strong crystallization tendency, limiting further advancements of this field. In this study, we demonstrate that the introduction of counterions effectively suppresses crystallization, as hydrogen bonds within the system stabilize the disordered structures. Based on this, we propose a counterion co-assembly strategy to synthesize a wide range of amino acid-based glasses. This strategy enables the facile fabrication of glass with customizable shapes, high mechanical rigidity, and tunable multicolor fluorescence, ranging from blue to red depending on the excitation wavelength. Furthermore, this strategy allows the integration and enhancement of counterion properties within the glass matrix. Through the co-assembly of phosphorescent counterions, we synthesized a series of long-persistent luminescent glasses with significantly extended afterglow lifetimes. This work presents an effective approach for the synthesis of amino acid-based glasses and provides insights into the development of supramolecular glasses with tailored functionalities.}, archive = {J_ANGEW}, author = {Xianbao Li and Yang Yang and Zhiqi Zhao and Shiwei Bai and Qi Li and Junbai Li}, doi = {10.1002/anie.202422272}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422272}, shortjournal = {Angew. Chem. Int. Edit.}, title = {General and versatile nanoarchitectonics for amino acid-based glasses via co-assembly of organic counterions}, volume = {64}, year = {2025}, }
• (2025). Enzymatic cascades for stereoselective and regioselective amide bond assembly. ANGEW, 64(13), e202422185. (www)

  @article{ , abstract = {Amide bond formation is fundamental in nature and is widely used in the synthesis of pharmaceuticals and other valuable products. Current methods for amide synthesis are often step and atom inefficient, requiring the use of protecting groups, deleterious reagents and organic solvents that create significant waste. The development of cleaner and more efficient catalytic methods for amide synthesis remains an urgent unmet need. Herein, we present novel biocatalytic cascade reactions for synthesising various amides under mild aqueous conditions from readily available organic nitriles combining nitrile hydrolysing enzymes and amide bond synthetase enzymes. These cooperative biocatalytic cascades enable kinetic resolution of racemic nitriles and provide a highly enantioselective biocatalytic extension of the Strecker reaction. The regioselective non-directed C−H bond amidation of simple arenes was demonstrated through the incorporation of photoredox catalysis to the front end of the cascade. C−H bond amidation of simple aromatic precursors was also achieved via a CO 2 fixation cascade combining enzymatic carboxylation and amide bond synthesis in one-pot.}, archive = {J_ANGEW}, author = {Daniele Torri and Luis Bering and Luke R. L. Yates and Stuart M. Angiolini and Guangcai Xu and Sebastian Cuesta-Hoyos and Sarah A. Shepherd and Jason Micklefield}, doi = {10.1002/anie.202422185}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202422185}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzymatic cascades for stereoselective and regioselective amide bond assembly}, volume = {64}, year = {2025}, }
• (2025). Bioinspired photo-thermal catalytic system using covalent organic framework-based aerogel for synchronous seawater desalination and H2O2 production. ANGEW, 64(13), e202421990. (www)

  @article{ , abstract = {Efficient utilization of solar energy is widely regarded as a crucial solution to addressing the energy crisis and reducing reliance on fossil fuels. Coupling photothermal and photochemical conversion can effectively improve solar energy utilization yet remains challenging. Here, inspired by the photosynthesis system in green plants, we report herein an artificial solar energy converter (ASEC) composed of light-harvesting units as solar collector and oriented ionic hydrophilic channels as reactors and transporters. Based on such architecture, the obtained ASEC (namely ASEC-NJFU-1) can efficiently realize parallel production of freshwater and H 2 O 2 from natural seawater under natural light. The total solar energy conversion (SEC) of ASEC-NJFU-1 reaches up to 8047 kJ m −2 h −1 , corresponding to production rates of freshwater and H 2 O 2 are 3.56 kg m −2−1 h −1 and 19 mM m −2 h −1 , respectively, which is a record-high value among all photothermal-photocatalytic systems reported to date. Mechanism investigation of combining spectrum and experimental studies indicated that the high SEC performance for ASEC-NJFU-1 was attributed to the presence of plant bioinspired architecture with carbon nanotubes as solar-harvestor and COF-based oriented aerogel as reactors and transporters. Our work thus establishes a novel artificial photosynthesis system for highly efficient solar energy utilization.}, archive = {J_ANGEW}, author = {Yaning Xu and Shiyan Ai and Tiantian Wu and Chengxu Zhou and Qing Huang and Baiyan Li and Dan Tian and Xian-He Bu}, doi = {10.1002/anie.202421990}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202421990}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bioinspired photo-thermal catalytic system using covalent organic framework-based aerogel for synchronous seawater desalination and H2O2 production}, volume = {64}, year = {2025}, }
• (2025). Scalable and low-energy synthesis of Metal–Organic frameworks by a seed-mediated approach. ANGEW, 64(13), e202421942. (www)

  @article{ , abstract = {The synthesis of metal–organic frameworks (MOFs) by low energy input has been a long-term target for practical applications yet remains a great challenge. Herein, we developed a low-energy MOF growth strategy at a temperature down to 50 °C by simply introducing seeds into the reaction system. The MOFs are continuously grown on the surface of the seeds at a growth rate dozens of times higher than that of conventional solvothermal synthesis at low temperature, while the resulting MOFs possess high crystallinity, porosity, and stability similar to solvothermal seeds. Remarkably, the obtained MOFs feature high-density structural defects with Lewis acidity, thereby displaying more than one order of magnitude higher activity than the MOFs obtained by the conventional solvothermal method in the iodination reaction of substituted arenes. This low-energy synthetic approach is readily scaled up, which would be a significant step forward in the dream of the MOF industry.}, archive = {J_ANGEW}, author = {Wentao Han and Minghao Shi and Hai-Long Jiang}, doi = {10.1002/anie.202421942}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202421942}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable and low-energy synthesis of Metal–Organic frameworks by a seed-mediated approach}, volume = {64}, year = {2025}, }
• (2025). Cationic, Iodine(III)-mediated and directed diastereoselective oxidation of inert C−H bonds in cyclic hydrocarbons. ANGEW, 64(13), e202421872. (www)

  @article{ , abstract = {Over the past three decades, the functionalization of unactivated C−H bonds has become a workhorse of synthesis. In the field of C−H bond oxygenation, most established methods hinge on single-electron reactivity, encountering challenges pertaining to regio- and/or stereocontrol. Herein, we describe a conceptually distinct strategy relying on the unique features of carbocation chemistry. Our iodine(III)-mediated method achieves the diastereoselective oxygenation of remote C−H bonds at traditionally unreactive sites and enables late-stage functionalization at steroidal frameworks as well as an unusual chirality relay.}, archive = {J_ANGEW}, author = {Nicolas G.-Simonian and Bogdan R. Brutiu and Daniel Kaiser and Nuno Maulide}, doi = {10.1002/anie.202421872}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202421872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cationic, Iodine(III)-mediated and directed diastereoselective oxidation of inert C−H bonds in cyclic hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). Electrochemical CO2 fixation and release cycle featuring a trinuclear zinc complex for direct air capture. ANGEW, 64(13), e202420703. (www)

  @article{ , abstract = {CO 2 capture technology can mitigate greenhouse gas emissions and global warming. CO 2 capture driven by electrochemical reactions is attractive because the operation is carried out at normal temperature and pressure and involves a simple input system using electrical energy. Although promising metal complexes with high CO 2 fixation performance have been reported, there are few studies on systems that combine electrochemical reactions and metal complexes. Here, we demonstrated stable CO 2 fixation-release cycles using an electrochemical system with trinuclear Zn(II) complex (Zn 3 L ) as the CO 2 fixative and an ionic liquid as a supporting electrolyte for the stable operation. This system showed a faster CO 2 fixation rate than that of an aqueous alkaline solution at the same concentration. Continuous release and refixation of CO 2 were achieved by decomposition and reconstruction of the complex structure induced by H + and OH − supplied from a bipolar membrane equipped in the electrolytic cell. The CO 2 fixation-release cycle was demonstrated even for dilute CO 2 (450 ppm) in air, where the CO 2 capture rate reached approximately 46 % of CO 2 contained in the air under an air flow condition of 200 mL ⋅ min −1 . This case, combining electrochemical drive and metal complexes, will provide a new option for CO 2 capture technology.}, archive = {J_ANGEW}, author = {Masakazu Murase and Naonari Sakamoto and Takeshi Uyama and Takamasa Nonaka and Masataka Ohashi and Shunsuke Sato and Takeo Arai and Toshiyuki Itoh}, doi = {10.1002/anie.202420703}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202420703}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical CO2 fixation and release cycle featuring a trinuclear zinc complex for direct air capture}, volume = {64}, year = {2025}, }
• (2025). Expanding polycyclic tetramate macrolactam (PoTeM) core structure diversity by chemo-enzymatic synthesis and bioengineering. ANGEW, 64(13), e202420335. (www)

  @article{ , abstract = {Polycyclic tetramate macrolactams (PoTeMs) represent a growing class of bioactive natural products that are derived from a common tetramate polyene precursor, lysobacterene A, produced by an unusual bacterial iterative polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS). The structural and functional diversity of PoTeMs is biosynthetically elaborated from lysobacterene A by pathway-specific cyclizing and modifying enzymes. This results in diverse core structure decoration and cyclization patterns. However, approaches to directly edit the PoTeM carbon skeleton do currently not exist. We thus set out to modify the PoTeM core structure by exchanging the natural l -ornithine-derived building block by l -lysine, hence extending macrocycle size by an additional CH 2 group. We developed streamlined synthetic access to lysobacterene A and the corresponding extended analog and achieved cyclization of both precursors by the cognate PoTeM cyclases IkaBC in vitro. This chemo-enzymatic approach corroborated the catalytic competence of IkaBC to produce a larger macrolactam yielding homo-ikarugamycin. We thus engineered the adenylation domain active site of IkaA to directly accept l -lysine, which upon co-expression with IkaBC delivered a recombinant bacterial homo-ikarugamycin producer. Our work establishes an entirely new PoTeM structural framework and sets the stage for the biotechnological diversification of the PoTeM natural product class in general.}, archive = {J_ANGEW}, author = {Sebastian Schuler and Manuel Einsiedler and Julia K. Evers and Mert Malay and Valdet Uka and Sabine Schneider and Tobias A. M. Gulder}, doi = {10.1002/anie.202420335}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202420335}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expanding polycyclic tetramate macrolactam (PoTeM) core structure diversity by chemo-enzymatic synthesis and bioengineering}, volume = {64}, year = {2025}, }
• (2025). Universal reagent for mild and stereospecific nucleophilic substitution of alcohols with amines. ANGEW, 64(13), e202420312. (www)

  @article{ , abstract = {A user-friendly reagent for mild and general activation of alcohols towards bimolecular nucleophilic substitution (S N 2) leveraging diverse nucleophiles, including primary and secondary amines is reported herein. The new ion-paired reagent discovery was based upon the putative zwitterionic betaine intermediate of the Mitsunobu reaction and enabled the one-step conversion of enantioenriched alcohols to valuable chiral C−X bonds (where X=N, C, S, O or halide). The described activating reagent has also been applied to a one-step methylation reaction using methanol and to an intermolecular amination/intramolecular cyclization sequence that generates heterocycles, such as tetrahydroisoquinolines. This work provides the first evidence by X-ray crystallography of a protonated betaine as intermediate in the Mitsunobu reaction.}, archive = {J_ANGEW}, author = {William S. Bechara and Irina K. Sagamanova and Léa Thai-Savard and Maxime Dauphinais and Sophie Régnier and Charlotte Noël and Scott B. D. Jarvis and André B. Charette}, doi = {10.1002/anie.202420312}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202420312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Universal reagent for mild and stereospecific nucleophilic substitution of alcohols with amines}, volume = {64}, year = {2025}, }
• (2025). Electrocatalytic water splitting in isoindigo-based covalent organic frameworks. ANGEW, 64(13), e202419836. (www)

  @article{ , abstract = {Developing a low-cost, robust, and high-performance electrocatalyst capable of efficiently performing both the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER) under both basic and acidic conditions is a major challenge. This area of research has attracted much attention in recent decades due to its importance in energy storage and conversion. Herein, we report the synthesis of two imine-linked isoindigo-based covalent organic networks I-TTA and I-TG (I=Isoindigo, TTA=4,4′,4′′-(1,3,5-triazine-2,4,6-triyl)-trianiline, TG=triamino-guanidinium hydrochloride salt). By introducing two amine core units with different planarity, such as triazine and ionic guanidinium units, we control the morphology, crystallinity, and corresponding electrocatalytic properties of the materials. The combination of isoindigo dialdehyde with a planar triazine core, leads to the formation of thin, highly crystalline, planar two dimensional (2D) nanosheets covalent organic framework (COF), I-TTA whereas its combination with ionic non-planar guanidinium core leads to an amorphous covalent organic polymer (COP), I-TG with a fibrous morphology. The sheet-like crystalline I-TTA COF shows better electrocatalytic activity compared to the amorphous fibrous I-TG COP. I-TTA exhibits a current density of 10 mA cm −2 at an overpotential of ~134 mV for HER (in 0.5 M H 2 SO 4 ) and ~283 mV for OER (in 1 M KOH). The electrocatalytic activity of the I-TTA COF in the OER exceeds that of other metal-free COFs. The catalytic activity is maintained even after 24 hours of chronoamperometry and 500 cycles of cyclic voltammetry (CV) at high scan rates.}, archive = {J_ANGEW}, author = {Gobinda Das and Suprobhat Singha Roy and Fayrouz Abou Ibrahim and Areej Merhi and Huda N. Dirawi and Farah Benyettou and Akshaya Kumar Das and Thirumurugan Prakasam and Sabu Varghese and Sudhir Kumar Sharma and Serdal Kirmizialtin and Ramesh Jagannathan and Felipe Gándara and Samer Aouad and Mark A. Olson and Subrata Kundu and Bilal R. Kaafarani and Ali Trabolsi}, doi = {10.1002/anie.202419836}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202419836}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrocatalytic water splitting in isoindigo-based covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Conduction band and defect engineering for the prominent visible-light responsive photocatalysts. ANGEW, 64(13), e202419624. (www)

  @article{ , abstract = {Controlling trap depth is crucial to improve photocatalytic activity, but designing such crystal structures has been challenging. In this study, we discovered that in 2D materials like BiOCl and Bi 4 NbO 8 Cl, composed of interleaved [Bi 2 O 2 ] 2+ and Cl- slabs, the trap depth can be controlled by manipulating the slab stacking structure. In BiOCl, oxygen vacancies (V O ) create deep electron traps, while chlorine vacancies (V Cl ) produce shallow traps. The depth is determined by the coordination around anion vacancies: V O forms strong σ bonds with Bi-6p dangling bonds below the conduction band minimum (CBM), while those around Cl are parallel, forming weak π-bonding. The strong re-hybridization makes the trap depth deeper. In Bi 4 NbO 8 Cl, V Cl also creates shallow traps, but V O does not produce deep traps although Bi-6p orbitals are also forming strong σ bonding. This difference is attributed to the difference of the energy level of CBM. In both cases, the CBM consists of Bi-6p orbitals extending into the Cl layers. However, these orbitals are isolated in BiOCl, but those in Bi 4 NbO 8 Cl are bonded with each other between neighboring [Bi 2 O 2 ] 2+ layers. This unique bonding-based CBM prevents the formation of deep electron traps, and significantly enhances H 2 evolution activity by prolonging the lifetime of highly reactive free electrons.}, archive = {J_ANGEW}, author = {Akira Yamakata and Kosaku Kato and Takafumi Ogawa and Kanta Ogawa and Makoto Ogawa and Daichi Kato and Chengchao Zhong and Akihide Kuwabara and Ryu Abe and Hiroshi Kageyama}, doi = {10.1002/anie.202419624}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202419624}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conduction band and defect engineering for the prominent visible-light responsive photocatalysts}, volume = {64}, year = {2025}, }
• (2025). Improving photocatalytic hydrogen generation via polycitric acid-based carbon nanodots. ANGEW, 64(13), e202418626. (www)

  @article{ , abstract = {Bottom-up syntheses of carbon nanodots (CND) using solvothermal treatment of citric acid are known to afford nanometer-sized, amorphous polycitric acid-based materials. The addition of suitable co-reactants in the form of in situ synthesized N -hetero-π-conjugated chromophores facilitates hereby the overall functionalization. Reports regarding the influence of CND on the properties of, for example, N -hetero-π-conjugated chromophores are scarce. Thus, our incentive was to design a CND model that features phenazine (P-CND) – a well-known N -hetero-π-conjugated chromophore – to investigate the influence of the CND matrix on its redox chemistry as well as photochemistry. The scope of our work was to go beyond investigating the electrochemical properties of the resulting P-CND by shedding light onto differences relative to nano-aggregates of phenazine (PNZ NA ), which served as reference. In particular, chemical as well as electrochemical reduction of PNZ NA initiated a reaction cascade that affords the primary reduction intermediate, that is, the reduced and protonated (PNZ-H)⋅. In accordance with existing literature, the final product of a bimolecular disproportionation was 5,10-dihydrophenazine (PNZ-H 2 ). Reducing P-CND also resulted in the formation of (PNZ-H)⋅. But, no evidence for a subsequent bimolecular disproportionation was gathered. Instead, (PNZ-H)⋅ as an integrative part of P-CND was found to be actively involved in a H 2 generation reaction. A more than twofold increase in efficiency compared to PNZ NA under identical conditions was the consequence.}, archive = {J_ANGEW}, author = {Daniel Langford and Yana Reva and Yifan Bo and Kirill Gubanov and Mingjian Wu and Ayşe Günay-Gürer and Lukas A. Mai and Ryan W. Crisp and Iryna Engelmann and Erdmann Spiecker and Rainer H. Fink and Axel Kahnt and Bikash Jana and Dirk M. Guldi}, doi = {10.1002/anie.202418626}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {13}, pages = {e202418626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving photocatalytic hydrogen generation via polycitric acid-based carbon nanodots}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Improving electrocatalytic CO2 reduction over iron tetraphenylporphyrin with triethanolamine as a CO2 shuttle. ANGEW, 64(12), e202581262. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhiyuan Yin and Mengchun Zhang and Yuchi Long and Haitao Lei and Xialiang Li and Xue-Peng Zhang and Wei Zhang and Ulf-Peter Apfel and Rui Cao}, doi = {10.1002/anie.202581262}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202581262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Improving electrocatalytic CO2 reduction over iron tetraphenylporphyrin with triethanolamine as a CO2 shuttle}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Ultrasensitive characterization of native bacterial biofilms via dynamic nuclear polarization-enhanced solid-state NMR. ANGEW, 64(12), e202581261. (www)

  @article{ , archive = {J_ANGEW}, author = {Chang-Hyeock Byeon and Ted Kinney and Hakan Saricayir and Kasper Holst Hansen and Faith J. Scott and Sadhana Srinivasa and Meghan K. Wells and Frederic Mentink-Vigier and Wook Kim and Ümit Akbey}, doi = {10.1002/anie.202581261}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202581261}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Ultrasensitive characterization of native bacterial biofilms via dynamic nuclear polarization-enhanced solid-state NMR}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Alcohol self-aggregation: The preferred configurations of the ethanol trimer (Angew. chem. int. ed. 12/2025). ANGEW, 64(12), e202503026. (www)

  @article{ , archive = {J_ANGEW}, author = {S. Indira Murugachandran and Isabel Peña and Al Mokhtar Lamsabhi and Manuel Yáñez and M. Eugenia Sanz}, doi = {10.1002/anie.202503026}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202503026}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Alcohol self-aggregation: The preferred configurations of the ethanol trimer (Angew. chem. int. ed. 12/2025)}, volume = {64}, year = {2025}, }
• (2025). Bimalendu adhikari. ANGEW, 64(12), e202502868. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202502868}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202502868}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bimalendu adhikari}, volume = {64}, year = {2025}, }
• (2025). Back cover: Diastereoselective polypseudorotaxane formation with planar chiral pillar[5]arenes via co-crystallization processes (Angew. chem. int. ed. 12/2025). ANGEW, 64(12), e202502767. (www)

  @article{ , archive = {J_ANGEW}, author = {Kiichi Yasuzawa and Keisuke Wada and Shixin Fa and Yuuya Nagata and Kenichi Kato and Shunsuke Ohtani and Motohiro Mizuno and Tomoki Ogoshi}, doi = {10.1002/anie.202502767}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202502767}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Diastereoselective polypseudorotaxane formation with planar chiral pillar[5]arenes via co-crystallization processes (Angew. chem. int. ed. 12/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Simultaneous fabrication of p and m helices in one-component chiral system by methanol-water mediated dual assembly pathway (Angew. chem. int. ed. 12/2025). ANGEW, 64(12), e202502496. (www)

  @article{ , archive = {J_ANGEW}, author = {Laiben Gao and Kaikai Yang and Chao Xing and Biyan Lin and Changli Zhao and Xiaoqiu Dou and Chuanliang Feng}, doi = {10.1002/anie.202502496}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202502496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Simultaneous fabrication of p and m helices in one-component chiral system by methanol-water mediated dual assembly pathway (Angew. chem. int. ed. 12/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Mechanics-photophysics correlation in tough, stretchable and long-lived room temperature phosphorescence ionogels deciphered by dynamic mechanical analysis (Angew. chem. int. ed. 12/2025). ANGEW, 64(12), e202502399. (www)

  @article{ , archive = {J_ANGEW}, author = {Xipeng Yang and Ningyan Li and Binbin Wang and Panyi Chen and Song Ma and Yifan Deng and Shaoyu Lü and Yu Tang}, doi = {10.1002/anie.202502399}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202502399}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Mechanics-photophysics correlation in tough, stretchable and long-lived room temperature phosphorescence ionogels deciphered by dynamic mechanical analysis (Angew. chem. int. ed. 12/2025)}, volume = {64}, year = {2025}, }
• (2025). Metal nanoclusters as highly efficient, versatile type-II photoinitiators via generating radicals from non-conventional hydrogen donors. ANGEW, 64(12), e202502217. (www)

  @article{ , abstract = {Development of highly efficient photocatalysis or photoinitiation systems that are applicable to various types of illumination source is critical to virtually all the light-driven applications. Here, we report a generalizable strategy to achieve highly sensitive, versatile photoinitiation systems based on the combination of metal nanoclusters with non-conventional hydrogen donors (co-initiators). Discovery of this type-II photoinitiation pathway in metal nanoclusters not only improves their two-photon initiation sensitivity by up to three-orders-of-magnitude, it further opens the door for metal nanoclusters to trigger the photopolymerization using the low-power UV light-emitting diodes. Different from molecular type-II photoinitiators, we found that the selection rules of hydrogen donors for metal nanoclusters are largely dependent on their ligand structures. More importantly, using electron paramagnetic resonance and mass spectroscopy, we for the first time demonstrate that the photoexcited metal nanoclusters can function as versatile hydrogen atom abstractors which generate various types of previously unreported thiyl and nitrogen-centered radicals. This finding indicates the broad opportunity of the future application of metal nanoclusters in light-driven organic synthesis and radical chemistry.}, archive = {J_ANGEW}, author = {Zijie Chen and Jin Tang and Letian Zheng and An Ren and Liang Ma and Qi Li}, doi = {10.1002/anie.202502217}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202502217}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal nanoclusters as highly efficient, versatile type-II photoinitiators via generating radicals from non-conventional hydrogen donors}, volume = {64}, year = {2025}, }
• (2025). Divergent total syntheses of six crinipellin-type diterpenoids through tandem 4π-Electrocyclization/Dicycloexpansion. ANGEW, 64(12), e202501008. (www)

  @article{ , abstract = {Crinipellins are a significant class of naturally occurring highly congested tetraquinane diterpenoids, with many members exhibiting bio-important antibacterial and anticancer activities. However, their complex structures, particularly their dense 5/5/5/5 tetracyclic frameworks, have made efficient synthesis challenging, leading chemists to attempt to create highly efficient and divergent routes. This study presents a concise, divergent synthesis of six crinipellins, completed in just 9–11 steps using commercially available materials. Particular highlights include: (1) a vital one-step 4π-electrocyclization/dicycloexpansion cascade that rapidly constructs the angular/fused tetraquinane scaffold with two contiguous quaternary carbons, and (2) strategic functionalizations through iso -propylation, methylation, and Wacker oxidation/dehydrogenation, enabling the divergent syntheses of the six crinipellin members without using protecting groups. This approach provides a versatile platform for accessing additional crinipellin derivatives, which we believe will benefit medicinal and biological research.}, archive = {J_ANGEW}, author = {Tian Ke and Si-Hua Hou and Yun-Peng Wang and Kun Fang and Jing-Han Hu and Ka Lu and Yong-Qiang Tu}, doi = {10.1002/anie.202501008}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202501008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent total syntheses of six crinipellin-type diterpenoids through tandem 4π-Electrocyclization/Dicycloexpansion}, volume = {64}, year = {2025}, }
• (2025). Validation and mechanistic studies of the headspace effect in MOF synthesis. ANGEW, 64(12), e202500531. (www)

  @article{ , abstract = {The influence of headspace volume and composition on metal–organic framework (MOF) synthesis has been largely overlooked with no mechanisms currently invoking these factors. Herein, we reveal that an increased volume of oxygen in the headspace during the synthesis of zinc carboxylate-based MOFs (MOF-5, MOF-177, and IRMOF-8) as well as UiO-66 and ZJU-28 accelerates crystal formation. Investigation into the underlying mechanism of this phenomenon elucidates the critical roles played by all reagents, and some of their byproducts, in MOF synthesis. These insights are the key to developing more efficient and sustainable synthetic strategies for MOF production.}, archive = {J_ANGEW}, author = {Julia C. Donovan and Keenan R. Wright and Adam J. Matzger}, doi = {10.1002/anie.202500531}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202500531}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Validation and mechanistic studies of the headspace effect in MOF synthesis}, volume = {64}, year = {2025}, }
• (2025). Metal−Organic framework with constrained flexibility for benchmark separation of hexane isomers. ANGEW, 64(12), e202500519. (www)

  @article{ , abstract = {Flexible metal−organic frameworks (MOFs) are promising candidates for adsorptive separations, but achieving a balance among flexibility, adsorption capacity, and selectivity remains challenging. Herein, we report a novel flexible MOF, Ni(bhdc)(ted) 0.5 (ZUL−C6), incorporating hybrid three-dimensional alkane-bridged ligands, which realizes high-capacity molecular sieving for hexane isomer separation - a critical process in the petroleum industry. The alkyl-rich, confined pore system within the ZUL−C6 framework facilitated a strong affinity for n-hexane and 3-methylpentane. However, the narrow pore size and the constrained flexibility limited the uptake of 2,2-dimethylbutane (<4.0 mg/g), accompanied by a high gate-opening pressure. The gating behavior was elucidated by guest-loaded single-crystal (SC) X-ray diffraction and density functional theory (DFT) simulations, which revealed a unique SC to SC transformation driven by the non-centrosymmetric rotation of the 3D bhdc linker and distortion of the metal cluster and pillar units, along with a high deformation energy barrier. As a result, ZUL−C6 exhibited not only significantly higher uptake and selectivity than the industrially used 5 A molecular sieve, but also the record-high nHEX/3MP breakthrough uptake (92.8/73.9 mg/g) and unprecedented 22DMB producing time (309.2 min/g, corresponding to the productivity of 770 mmol/kg and yield of 92.8 %) among reported MOFs.}, archive = {J_ANGEW}, author = {Kuishan Wen and Jingyi Zhou and Tian Ke and Jinjian Li and Yuanyuan Jin and Qianglong Zhang and Zhiguo Zhang and Zongbi Bao and Qilong Ren and Qiwei Yang}, doi = {10.1002/anie.202500519}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202500519}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal−Organic framework with constrained flexibility for benchmark separation of hexane isomers}, volume = {64}, year = {2025}, }
• (2025). Selective and potent molecular glue degraders for NIMA-related kinase 7. ANGEW, 64(12), e202500169. (www)

  @article{ , abstract = {Molecular glue degraders (MGDs) represent a promising strategy for targeted protein degradation within cells. While chemoproteomics has unveiled hundreds of potential MGD targets, very few proteins are degraded by highly selective and potent MGDs. Here, we developed a novel glutarimide analog with a tetrahydroimidazo[1,2- a ]pyrazine scaffold that exhibited strong NIMA-related kinase 7 (NEK7) degradation potential. Further optimization led to the identification of LC-04-045 as a leading NEK7 MGD candidate, demonstrating potent activity with a half-maximal degradation (DC 50 ) of 7 nM and a maximum degradation (D max ) of 90 % in MOLT-4 cells. Notably, LC-04-045 displayed high selectivity for NEK7 across the proteome. Mechanistic studies indicated that the degradation was mediated by the ubiquitin-proteasome system (UPS) and relied on the glycine 57 (G57)-containing degron motif in NEK7. Additionally, two amino acids adjacent to the degron motif were found to be crucial for modulating the compound's selectivity and potency, underscoring the significance of neighbouring residues in MGD design. Moreover, LC-04-045 effectively inhibited secretion of the downstream cytokines, including IL-1β and IL-18, highlighting the potential therapeutic applications of NEK7 MGDs in treating inflammatory diseases.}, archive = {J_ANGEW}, author = {Lu Chen and Lu Huang and Wuqiang Wen and Pingping Zeng and Yuanyuan Wu and Qiangqiang Han and Xi Chen and Zhixiang Guo and Haijun Yu and Wenchao Lu and Baishan Jiang}, doi = {10.1002/anie.202500169}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202500169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective and potent molecular glue degraders for NIMA-related kinase 7}, volume = {64}, year = {2025}, }
• (2025). Improving electrocatalytic CO2 reduction over iron tetraphenylporphyrin with triethanolamine as a CO2 shuttle. ANGEW, 64(12), e202500154. (www)

  @article{ , abstract = {Delivering CO 2 molecules to catalyst sites is a vital step in the CO 2 reduction reaction (CO 2 RR). Achievements have been made to develop efficient catalysts, but few efforts have been dedicated to improving CO 2 delivering in solutions. Herein, we report on electrocatalytic CO 2 -to-CO conversion using Fe tetraphenylporphyrin (FeTPP) as a catalyst and triethanolamine as a CO 2 shuttle. Compared to ethanol, the electrocatalytic CO 2 RR current with triethanolamine increases by more than three times. We show that triethanolamine can effectively capture a CO 2 molecule to form a zwitterionic alkylcarbonate through the collaboration between its tripodal alcohol and amine units. This alkylcarbonate can release the bound CO 2 molecule for activation at the Fe site upon its interaction with FeTPP. In addition to shuttling CO 2 , alkylcarbonates can also provide protons to assist the C−O bond cleavage. Therefore, this work is significant to demonstrate a new strategy to improve electrocatalytic CO 2 RR by shuttling CO 2 .}, archive = {J_ANGEW}, author = {Zhiyuan Yin and Mengchun Zhang and Yuchi Long and Haitao Lei and Xialiang Li and Xue-Peng Zhang and Wei Zhang and Ulf-Peter Apfel and Rui Cao}, doi = {10.1002/anie.202500154}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202500154}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving electrocatalytic CO2 reduction over iron tetraphenylporphyrin with triethanolamine as a CO2 shuttle}, volume = {64}, year = {2025}, }
• (2025). Poly(2-hydroxymethyl-2-oxazoline) as super-hydrophilic antifouling polymer. ANGEW, 64(12), e202424873. (www)

  @article{ , abstract = {Non-ionic “super-hydrophilic” polymers generally possess strong non-fouling characteristics and, therefore, can suppress non-specific and unwanted interactions with blood proteins when attached to in vivo nanomedicine ranging from drug or gene delivery to diagnostics. In this contribution, we revitalize a protected alcohol functionalized 2-oxazoline monomer, 2-acetoxymethyl-2-oxazoline, that was first reported almost fifty-five years ago and explore the possibility of making “super-hydrophilic” poly(2-oxazoline)s for biomedical applications. The synthesis of the 2-acetoxymethyl-2-oxazoline monomer and its cationic ring-opening homopolymerization and copolymerization kinetics are reported. The monomer showed unanticipated and intriguing reactivity during homopolymerization as it very slowly polymerizes at low temperature while the polymerization rate constant at high temperature is amongst the highest known values. Additionally, first order kinetic plots for the copolymerisation of AcOMeOx with EtOx at high temperature revealed that AcOMeOx is incorporated at a slower rate than EtOx confirming its lower nucleophilicity, while EtOx was accelerated in the copolymerization indicating chain-end activation by the ester side-chains. Subsequently, controlled hydrolysis of the resulting poly(2-acetoxymethyl-2-oxazoline) (PAcOMeOx) generates the alcohol (−OH) side chain functional poly(2-hydroxymethyl-2-oxazoline) (PHOMeOx). The relative hydrophilicity of PHOMeOx was analyzed and compared with the previously reported most hydrophilic poly(2-oxazoline)s, such as poly(2-methoxymethyl-2-oxazoline) and poly(2-methyl-2-oxazoline), revealing that PHOMeOx is the most hydrophilic poly(2-oxazoline) reported to date. Finally, the cytocompatibility of these different hydrophilic polymers with MDA-MB-231 breast cancer cells was explored where all polymers revealed high cytocompatibility. Most importantly, strong anti-fouling properties of the most hydrophilic PHOMeOx against serum protein were observed during the cell association studies. Hence, the “super-hydrophilic” and anti-fouling PHOMeOx might be an interesting candidate to be explored in the area of polymeric drug and gene delivery as well as anti-fouling surfaces.}, archive = {J_ANGEW}, author = {Somdeb Jana and Milan Roels and Meike N. Leiske and Yann Bernhard and Bruno G. De Geest. and Kristof Van Hecke and Richard Hoogenboom}, doi = {10.1002/anie.202424873}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424873}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Poly(2-hydroxymethyl-2-oxazoline) as super-hydrophilic antifouling polymer}, volume = {64}, year = {2025}, }
• (2025). Halogenated Donor–Acceptor cyclopropanes as Donor–Acceptor cyclopropene surrogates. ANGEW, 64(12), e202424823. (www)

  @article{ , abstract = {Herein we report (3+2)-cycloaddition reactions of halogenated donor–acceptor cyclopropanes (HDACs) as surrogates for donor–acceptor cyclopropenes. Upon reaction with a variety of 2π-components, cycloaddition followed by elimination generates the unsaturated five-membered ring products. A series of HDACs were shown to be effective in reactions with thioketones. Five further cycloaddition reactions were used to showcase the broad applicability of these donor–acceptor cyclopropene surrogates. Kinetic studies allowed the proposal of a plausible mechanism for this reaction.}, archive = {J_ANGEW}, author = {Gwyndaf A. Oliver and Simon Kolb and Malini George and Daniel B. Werz}, doi = {10.1002/anie.202424823}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424823}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogenated Donor–Acceptor cyclopropanes as Donor–Acceptor cyclopropene surrogates}, volume = {64}, year = {2025}, }
• (2025). Surface-like NOx reduction at an atomically-precise tricopper cluster. ANGEW, 64(12), e202424772. (www)

  @article{ , abstract = {The combustion of nitrogen-containing fuels and increasing use of nitrogen-rich fertilizers is accumulating NO x pollutants in the environment. Copper is an attractive catalyst material for reductive NO x remediation, yet ambiguity persists regarding the elementary bond-making and bond-breaking steps occurring at the catalyst interface. Starting from a molecular tricuprous μ 3 -oxo complex ( 1 ), an unusually reduced and highly reactive surface-like cluster ( 2 ) has been prepared. Characterization data and electronic structure calculations are consistent with 2 featuring σ-aromaticity that primes the tricopper core for two-electron chemistry. Cluster 2 mediates catalytic reductive coupling of NO to N 2 , proceeding through N 2 O, via sequential oxygen atom transfer steps. Stoichiometric reduction of NO 3 − and NO 2 − is also disclosed, mapping the complete denitrification cycle at an atomically-precise molecular cluster.}, archive = {J_ANGEW}, author = {Andrew W. Beamer and Joshua A. Buss}, doi = {10.1002/anie.202424772}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface-like NOx reduction at an atomically-precise tricopper cluster}, volume = {64}, year = {2025}, }
• (2025). Engineering two-dimensional nanomaterials for photothermal therapy. ANGEW, 64(12), e202424768. (www)

  @article{ , abstract = {Two-dimensional (2D) nanomaterials offer a transformative platform for photothermal therapy (PTT) due to their unique physicochemical properties and exceptional photothermal conversion efficiencies. This Minireview summarizes the photothermal mechanisms of common 2D nanomaterials and details their synthesis, surface modification, and optimization strategies. Recent advances leveraging 2D nanomaterials for enhanced PTT are highlighted, with particular emphasis on synergistic therapeutic modalities. Despite the significant potential of 2D nanomaterials in PTT, challenges persist, including scalable and reproducible manufacturing, precise targeted delivery, understanding of the underlying biological interactions, and comprehensive assessment of long-term biocompatibility and toxicity. Looking forward, emerging technologies such as machine learning are expected to play a crucial role in accelerating the design and optimization of 2D nanomaterials for PTT, enabling the prediction of optimal structures, properties, and therapeutic efficacy, and ultimately paving the way for personalized nanomedicine.}, archive = {J_ANGEW}, author = {Haoyuan Zhang and Min Yang and Qingyuan Wu and Jiajia Xue and Huiyu Liu}, doi = {10.1002/anie.202424768}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424768}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering two-dimensional nanomaterials for photothermal therapy}, volume = {64}, year = {2025}, }
• (2025). Functional polyolefins and composites. ANGEW, 64(12), e202424529. (www)

  @article{ , abstract = {Polyolefins are simple hydrocarbons that require additional chemical modifications or functional additives to give them custom functions. Recent research in the development of functional polyolefins has surpassed the traditional approach of simply improving surface properties by incorporating polar moieties. Creating custom functionalized polyolefins by using specific functional units has attracted increasing attention. This review summarizes advances in preparing custom functionalized polyolefin materials using functional units such as comonomers, chain-transfer agents, post-polymerization modification reagents, and functional fillers. Exploring new functional units and innovative synthetic strategies will further enhance the performance and expand the applications of functional polyolefins.}, archive = {J_ANGEW}, author = {Chen Tan and Guifu Si and Chen Zou and Changle Chen}, doi = {10.1002/anie.202424529}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424529}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functional polyolefins and composites}, volume = {64}, year = {2025}, }
• (2025). Fluorescent macrocyclic arenes: Synthesis and applications. ANGEW, 64(12), e202424276. (www)

  @article{ , abstract = {Fluorescent macrocyclic arenes have attracted increasing interest in macrocyclic and supramolecular chemistry due to their exceptional photophysical properties and versatile applications. Classical macrocyclic arenes modified with fluorescent groups at the upper or bottom rims have long provided valuable platforms across various fields. Recently, a large number of novel fluorescent macrocyclic arenes directly composed of polycyclic aromatic or heteroaromatic building blocks including naphthalene, anthracene, tetraphenylethene, pyrene, fluorene, carbazole, acridan, phenothiazine, coumarin, triphenylamine, benzothiadiazole and so on, have been reported, and they have shown specific fluorescent property, and also exhibited broad applications in molecular recognition, sensing, bioimaging and functional materials. In this review, we focus on the recent advances in the synthesis and applications of fluorescent macrocyclic arenes containing polycyclic aromatic or heteroaromatic skeletons emerged in the past decade. By categorizing these fluorescent macrocyclic arenes based on the different building blocks, this review provides a comprehensive summary of their synthesis, properties and applications.}, archive = {J_ANGEW}, author = {Xiao-Ni Han and Ying Han and Chuan-Feng Chen}, doi = {10.1002/anie.202424276}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424276}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorescent macrocyclic arenes: Synthesis and applications}, volume = {64}, year = {2025}, }
• (2025). Molecular customization of anode-electrolyte interfaces for enhanced stability and reversibility in aqueous zinc-carbon capacitors. ANGEW, 64(12), e202424255. (www)

  @article{ , abstract = {Aqueous zinc-carbon capacitors display application potential in green power and high-end equipment owing to their high security, large power and sustainability. The water-rich zinc anode-electrolyte interface (AEI) and disordered zinc-ion diffusion are the culprits triggering corrosion reactions and dendrite growth, threatening the sustainability of aqueous zinc-carbon capacitors. Herein, a polyfunctional biomolecular, vitamin B 6 , is introduced into the traditional aqueous electrolyte for customizing the functional AEI and fine-regulating the interfacial coordination environment of zinc ions. Specifically, the preferential anchoring of pyridine nitrogen enables trace vitamin (2.0 g L −1 ) to construct a robust AEI and suppress corrosion reactions. The hydroxyl function zone provides high-octane guidance for zinc-ion diffusion at the AEI, resulting in flat zinc (002) oriented growth. Consequently, the Zn//Zn symmetrical cell features an ultrahigh cumulative capacity of 4.0 Ah cm −2 under 34 % depth of discharge. The vitamin-optimized zinc-carbon capacitor features extended operational lifetimes exceeding 8 months (200 thousand cycles at 5.0 A g −1 ), and demonstrates a high areal capacity of averaging 0.68 mAh cm −2 and exceptional durability over 2000 hours at 1.0 A g −1 under a high discharge depth of zinc anode (averaging 11.6 %). This work offers valuable insights into sustainable and cost-effective zinc-carbon capacitors.}, archive = {J_ANGEW}, author = {Yang Xu and Jingzhu Chen and Tao Li and Hexian Ma and Zhuoran Lv and Shicong Zhang and Hui Bi and Fuqiang Huang and Tianquan Lin}, doi = {10.1002/anie.202424255}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424255}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular customization of anode-electrolyte interfaces for enhanced stability and reversibility in aqueous zinc-carbon capacitors}, volume = {64}, year = {2025}, }
• (2025). Synergistic enhancement of plasma-driven ammonia synthesis using a AuCu3/Cu composite catalyst. ANGEW, 64(12), e202424165. (www)

  @article{ , abstract = {Green ammonia synthesis using fluctuating renewable energy supply in decentralized process is a goal that has been long sought after. Ammonia synthesis with non-thermal plasma under mild conditions is a promising technology, but it faces the critical challenge of low energy efficiency. Herein, we develop an easily-scalable AuCu 3 /Cu catalyst, which consists of a decimeter-scale metallic Cu antenna and nano-scale AuCu 3 catalytic sites on metallic Cu surface, significantly enhancing the energy efficiency and ammonia yield in a radio-frequency (RF) plasma system. Compared to plasma alone, the single-pass ammonia yield over AuCu 3 /Cu increases by a factor of 20, approaching 10 %. Mechanistic studies indicate that Cu antenna can amplify the millimeter-scale local electric field, thereby facilitating the generation of active nitrogen species, including nitrogen radicals and vibration-excited nitrogen molecules. Due to the downshifted d-band center and unique Cu−Au interface structure, the AuCu 3 nanoalloy modified on Cu antenna surface significantly reduces hydrogenation barriers of active NH X ( x =0,1,2) species (the rate-determining step) and facilitates ammonia desorption at lower temperature. The synergistic effect of Cu antenna and surface AuCu 3 nanoalloy comprehensively enhances ammonia synthesis through both the nitrogen radical-mediated Eley-Rideal pathway and the vibration-excited nitrogen molecule-mediated Langmuir–Hinshelwood pathway.}, archive = {J_ANGEW}, author = {Zhenlu Li and Shize Liu and Qingyun Zhan and Jiayang Li and Zihao Zhang and Yumeng Qian and Yiyu Cai and Xiaoyue Mu and Lu Li}, doi = {10.1002/anie.202424165}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202424165}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic enhancement of plasma-driven ammonia synthesis using a AuCu3/Cu composite catalyst}, volume = {64}, year = {2025}, }
• (2025). Multifaceted hidden catalysis revealed by mechanistic analysis of FeBr3-catalysed arene borylation. ANGEW, 64(12), e202423929. (www)

  @article{ , abstract = {Arene borylation reactions provide direct access to aryl organoboranes, including aryl boronic esters. Precious metals, namely Ir, Rh, Pt, remain the go-to for metal-catalysed borylation reactions, however, significant efforts have been expended in developing Earth-abundant metal alternatives. The iron-catalysed borylation of 2-aryl pyridine derivatives with 9-borabicyclo[3.3.1]nonane (H- B -9-BBN) offers unique reactivity by using only FeBr 3 as the catalyst, without added ligand(s). Mechanistic analysis of this borylation reaction revealed an alternative, hidden catalysis pathway whereby the iron salt acts not as a borylation catalyst, but as an initiator for the generation of a catalytically active haloborane, Br- B -9-BBN. The roles of iron salt, Br- B -9-BBN, and HBr in catalyst formation, the mode of catalytic turnover, and catalyst regeneration were all determined using single-turnover and catalytic studies. The borylation reaction was found to proceed by a catalytic electrophilic borylation using, in situ generated, Br- B -9-BBN. These studies highlight a new, orthogonal method of generating haloboranes and their previously unobserved role as hidden catalysts within arene borylation reactions.}, archive = {J_ANGEW}, author = {Luke Britton and Andrew D. Bage and Sarah L. McOnie and Stephen P. Thomas}, doi = {10.1002/anie.202423929}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423929}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multifaceted hidden catalysis revealed by mechanistic analysis of FeBr3-catalysed arene borylation}, volume = {64}, year = {2025}, }
• (2025). Simultaneous high current density and selective electrocatalytic CO2-to-CH4 through intermediate balancing. ANGEW, 64(12), e202423915. (www)

  @article{ , abstract = {The electrochemical reduction of CO 2 to CH 4 is promising for carbon neutrality and renewable energy storage but confronts low CH 4 selectivity, especially at high current densities. The key challenge lies in promoting *CO intermediate and *H coupling while minimizing side reactions including C−C coupling and H−H coupling, which is particularly difficult at high current density due to abundant intermediates. Here we report a cooperative strategy to address this challenge using Cu-based catalysts comprising Cu−N coordination polymer and CuO component that can simultaneously manage the key intermediates *CO and *H. A fast CO 2 -to-CH 4 conversion rate of 3.14 mmol cm −2 h −1 is achieved at 1,300 mA cm −2 with a Faradaic efficiency of 51.7 %. In situ spectroscopy and theoretical calculations show that the increased Cu−Cu distance in the Cu−N coordination polymer component favors multistep *CO hydrogenation over the dimerization, and the CuO component ensures an adequate supply of *H, together contributing to the selective CO 2 -to-CH 4 conversion at high current densities. This work develops a cooperative strategy for the electrosynthesis of CH 4 with simultaneous high current density and high selectivity by rational catalyst design, paving the way for its applications.}, archive = {J_ANGEW}, author = {Shuqi Hu and Yumo Chen and Zhiyuan Zhang and Heming Liu and Xin Kang and Jiarong Liu and Shanlin Li and Yuting Luo and Bilu Liu}, doi = {10.1002/anie.202423915}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423915}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous high current density and selective electrocatalytic CO2-to-CH4 through intermediate balancing}, volume = {64}, year = {2025}, }
• (2025). Molecular micellar aggregate electrolytes enable durable electrochemical proton storage. ANGEW, 64(12), e202423908. (www)

  @article{ , abstract = {Proton electrochemistry holds eminent potential for developing high capacity and rate energy storage devices in the post-lithium era. However, the decomposition of water in acidic aqueous electrolytes causes electrode corrosion, leading to capacity fading. Herein, we report a judicious design of molecular micellar aggregates as non-aqueous electrolytes for stable and high-voltage electrochemical proton storage. The key to our strategy lies in introducing cetyltrimethylammonium bromide (CTAB), forming micelles to improve the miscibility of acetonitrile (ACN) and H 3 PO 4 , afford channel for proton transport, and electrostatically interact with phosphate ions of H 3 PO 4 to further promote proton transport. Such aggregates impart rapid and stable electrochemical proton storage with a widened operating voltage (1.8 V vs. 1.5 V in aqueous electrolyte). By optimizing CTAB content, proton transport can be enhanced. Asymmetric full proton battery using the optimal CTAB electrolyte achieves a maximum energy density of 102.8 Wh kg −1 and a maximum power density of 10.1 kW kg −1 . Our simple yet robust route to micellar aggregate electrolytes enables stable proton storage, underscoring its potential for grid-scale energy storage, emergency power supplies, and portable electronics.}, archive = {J_ANGEW}, author = {Xiaoyu Dong and Zhiwei Li and Zhiyuan Wu and Fanhao Meng and Hong Xiao and Hai Xu and Xiaogang Zhang and Zhiqun Lin and Hui Dou}, doi = {10.1002/anie.202423908}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423908}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular micellar aggregate electrolytes enable durable electrochemical proton storage}, volume = {64}, year = {2025}, }
• (2025). Partially interstitial silicon-implanted ruthenium as an efficient electrocatalyst for alkaline hydrogen evolution. ANGEW, 64(12), e202423756. (www)

  @article{ , abstract = {To enhance the alkaline hydrogen evolution reaction (HER), it is crucial, yet challenging, to fundamentally understand and rationally modulate potential catalytic sites. In this study, we confirm that despite calculating a low water dissociation energy barrier and an appropriate H adsorption free energy (ΔG *H ) at Ru-top sites, metallic Ru exhibits a relatively inferior activity for the alkaline HER. This is primarily because the Ru-top sites, which are potential H adsorption sites, are recessive catalytic sites, compared with the adjacent Ru-hollow sites that have a strong ΔG *H . To promote the transformation of Ru-top sites from recessive to dominant catalytic sites, interstitial Si atoms are implanted into the hollow sites. However, complete interstitial implantation leads to a high water dissociation energy barrier at the RuSi intermetallic surface. Thus, we present a partial interstitial incorporation strategy to form a Ru−RuSi heterostructure that not only converts the Ru-top sites from recessive to dominant catalytic sites but also preserves the low water dissociation energy barrier at the Ru surface. Moreover, the spontaneously formed built-in electric fields bidirectionally optimize the adsorption ability of the Ru sites, thereby greatly reducing the thermodynamic energy barrier and enhancing the alkaline HER.}, archive = {J_ANGEW}, author = {Liqiang Hou and Zijian Li and Haeseong Jang and Min Gyu Kim and Jaephil Cho and Wenwu Zhong and Shangguo Liu and Xien Liu}, doi = {10.1002/anie.202423756}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423756}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Partially interstitial silicon-implanted ruthenium as an efficient electrocatalyst for alkaline hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Chalcogen bonding catalysis enables ring-opening of cyclopropene and ring expansion of aryl ketones. ANGEW, 64(12), e202423746. (www)

  @article{ , abstract = {Catalytic transformation of carbene species constitutes a fundamental part in organic synthesis, and the research in this direction has been dominated by transition metals while organic catalysts are difficult to mimic such transition-metal-like reactivity. It would significantly advance carbene chemistry if organic catalysts enable achieving classical metal-carbene approaches otherwise unrealizable reactions. Herein, we report that chalcogen bonding catalysis can solve reactivity problem to achieve an elusive Buchner ring expansion of aryl ketones appending a cyclopropene moiety as carbene precursor. In this work, the ring-opening of cyclopropene and the ring-expansion of aryl systems were added in the field of noncovalent catalysis. This work demonstrates that chalcogen bonding can mediate carbene transformations beyond the known ionic approach. In contrast, transition metals such as rhodium, palladium, and copper complexes, could not solve the reactivity problem to achieve ring expansion of aryl ketones but instead these metal-carbene approaches prefer the formation of furan side product. In addition, a thermal approach even being conducted at 200 °C could not achieve this ring expansion reaction. Mechanistic investigation suggests Se⋅⋅⋅π interaction with cyclopropene facilitates the ring-opening of cyclopropene and chalcogen bonding with carbene intermediate changes the reaction pathway, thus overriding the furan reaction pathway.}, archive = {J_ANGEW}, author = {Haofu Zhu and Xiaomei Yang and Yi Liu and Hang Zhou and Yao Wang}, doi = {10.1002/anie.202423746}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chalcogen bonding catalysis enables ring-opening of cyclopropene and ring expansion of aryl ketones}, volume = {64}, year = {2025}, }
• (2025). Surface coverage tuning for suppressing over-oxidation: A case of photoelectrochemical alcohol-to-Aldehyde/Ketone conversion. ANGEW, 64(12), e202423730. (www)

  @article{ , abstract = {Suppressing over-oxidation is a crucial challenge for various chemical intermediate synthesis in heterogeneous catalysis. The distribution of oxidative species and the substrate coverage, governed by the direction of electron transfer, are believed to influence the oxidation extent. In this study, we presented an experimental realization of surface coverage modulation on a photoelectrode using a photo-induced charge activation method. Through the surface coverage modulation, both pre-oxidized alcohol substrates and surface coverage were increased, which not only improved the reaction kinetics but also suppressed the over-oxidation of the generated aldehydes/ketones. As a demonstration, the Faradaic efficiency for the conversion of glycerol to dihydroxyacetone increased from 31.8 % to 46.8 % (with selectivity rising from 47.6 % to 71.3 %), from 73.4 % to 87.8 % for benzyl alcohol to benzyl aldehyde (selectivity increasing from 76.7 % to 92.4 %) and from 4.2 % to 53.6 % for ethylene glycol to glycolaldehyde (selectivity increasing from 6.2 % to 62.7 %). Our findings offer a promising strategy for the production of high-value carbon products in heterogeneous catalysis.}, archive = {J_ANGEW}, author = {Chaoran Dong and Cheng Lin and Panjie Li and Jong Hyeok Park and Jinyou Shen and Kan Zhang}, doi = {10.1002/anie.202423730}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423730}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface coverage tuning for suppressing over-oxidation: A case of photoelectrochemical alcohol-to-Aldehyde/Ketone conversion}, volume = {64}, year = {2025}, }
• (2025). Inverting methanol dehydrogenation selectivity by crowding atomic ni species over α-MoC catalysts. ANGEW, 64(12), e202423682. (www)

  @article{ , abstract = {Metal carbides with earth-abundant elements are widely regarded as promising alternatives to noble metal catalysts. Although comparable catalytic performances have been observed for metal carbides in several types of reactions, precise control of reaction pathways on them remains a formidable challenge, partially due to strong adsorption of reactants or intermediates. In this study, we show that bimolecular dehydrogenation of methanol to methyl formate and H 2 is kinetically favored on bare α -MoC catalysts, while monomolecular dehydrogenation to CO and H 2 becomes the dominant pathway when α -MoC is decorated with crowding atomic Ni species. Under optimal conditions, excellent selectivities of the target products (>90 %) were achieved in both cases, with unprecedented production rates of methyl formate and H 2 for the former and latter mechanisms, respectively. Kinetic, spectroscopic, and computational assessments were integrated to clarify the mechanism driving this remarkable selectivity inversion. Isolated Ni sites bound to α -MoC exhibit superior dehydrogenation activity, which promotes complete cleavage of C−H bonds in methanol-derived intermediates rather than the C−O coupling between them. Our study offers an effective approach to modulating the selectivity of carbide-based catalysts in alcohol dehydrogenation towards different target products.}, archive = {J_ANGEW}, author = {Yuzhen Ge and Zirui Gao and Yao Xu and Ming Xu and Xuetao Qin and Mi Peng and Shuai Wang and Rui Gao and Wu Zhou and Ding Ma}, doi = {10.1002/anie.202423682}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423682}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inverting methanol dehydrogenation selectivity by crowding atomic ni species over α-MoC catalysts}, volume = {64}, year = {2025}, }
• (2025). Isomerism effect of 3D dimeric acceptors for non-halogenated solvent-processed organic solar cells with 20 % efficiency. ANGEW, 64(12), e202423562. (www)

  @article{ , abstract = {Organic photovoltaic materials that can be processed via non-halogenated solvents are crucial for the large-area manufacturing of organic solar cells (OSCs). However, the limited available of electron acceptors with adequate solubility and favorable molecular packing presents a challenge in achieving efficient non-halogenated solvent-processed OSCs. Herein, inspired by the three-dimensional dimeric acceptor CH8-4, we employed a molecular isomerization strategy to synthesize its isomers, CH8-4A and CH8-4B, by tuning the position of fluorine (F) atom in the central unit. The differing intramolecular fluorine-sulfur non-covalent interactions among these isomers led to differences in molecular pre-aggregation abilities (CH8-4B<CH8-4<CH8-4A) in o -xylene ( o -XY) solution, which significantly influence the film-forming process and the resultant morphological characteristics. Among these, the blend film of CH8-4, characterized by moderate molecular pre-aggregation, achieved optimal bi-continuous donor/acceptor phase separation. Consequently, the o -xylene processed PM6 : CH8-4 device achieved a power conversion efficiency (PCE) of 18.1 %, outperforming that of two other devices. By incorporating L8-BO-D as a guest acceptor, we attained an impressive PCE of 20.0 % for the CH8-4-based ternary device, alongside a high PCE nearing 16 % for the mini-module (13.5 cm 2 ). Our findings underscore the potential of isomerism in 3D dimer acceptors to enhance the performance of eco-friendly OSCs.}, archive = {J_ANGEW}, author = {Jia Wang and Peiran Wang and Tianqi Chen and Wenkai Zhao and Jiaying Wang and Baofa Lan and Wanying Feng and Hang Liu and Yongsheng Liu and Xiangjian Wan and Guankui Long and Bin Kan and Yongsheng Chen}, doi = {10.1002/anie.202423562}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423562}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isomerism effect of 3D dimeric acceptors for non-halogenated solvent-processed organic solar cells with 20 % efficiency}, volume = {64}, year = {2025}, }
• (2025). Spherical Mg/Cu co-doped Na4Fe3(PO4)2P2O7 cathode materials with mitigated diffusion-induced stresses and enhanced cyclic stability. ANGEW, 64(12), e202423296. (www)

  @article{ , abstract = {Na 4 Fe 3 (PO 4 ) 2 P 2 O 7 (NFPP) has been regarded as the promising cathode material for sodium-ion batteries (SIBs). However, the practical applications of NFPP are hindered by its high-volume changes, poor intrinsic electron conductivity and sluggish Na+ ions diffusion kinetics. Herein, a spray-drying and solid-state reaction method have been utilized to fabricate the spherical trace amount Mg/Cu co-doped Na 4 Fe 3 (PO 4 ) 2 P 2 O 7 (NFMCPP). The Mg/Cu co-doping can effectively mitigate the lattice volume change and promote the electronic conductivity of NFMCPP by reducing band gap between the conduction and valence bands. While, the unique spherical structured NFMCPP with a carbon film even coated on its surface ensures rapid electron transport. Moreover, small NFMCPP particles with spherical geometry demonstrate an alleviated diffusion-induced stress and enhanced structural stability, due to the high sphericity structure enables fluent Na + extraction/insertion, leads to a low high-stress concentration and uniform stress/strain distribution during extensive (de)sodiation process. Consequently, the optimized spherical NFMCPP cathode materials exhibit an excellent rate capability and cyclic stability.}, archive = {J_ANGEW}, author = {Fan Peng and Pengyuan Dong and Changdong Chen and Youqi Chu and Wenxue Min and Anjie Lai and Hao Wang and Chenghao Yang}, doi = {10.1002/anie.202423296}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423296}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spherical Mg/Cu co-doped Na4Fe3(PO4)2P2O7 cathode materials with mitigated diffusion-induced stresses and enhanced cyclic stability}, volume = {64}, year = {2025}, }
• (2025). High-temperature-mediated assembly of polyoxometalate-induced ordered carbonaceous superstructures. ANGEW, 64(12), e202423242. (www)

  @article{ , abstract = {Constructing hierarchical superstructures through one-step bottom-up synthesis poses significant challenges due to strong interactions between additives and micelles, which hinders the formation of heterogeneous configurations. Here, we propose a high-temperature-mediated method to weaken these interactions and manipulate the thermal instability of micellar templates. This approach successfully synthesizes hierarchical superstructures that combine a carbonaceous nanosheet substrate with polyoxometalate (POM)-induced, highly ordered discontinuous nanodots in a single preparation step. The surface nanodots have a diameter of approximately 19 nm and are spaced about 32 nm apart. Besides, the nanodots with various arrangements can be generated by simply adjusting the amount of POM. Importantly, the superstructure features more exposed POM catalytic sites than conventional carbonaceous hybrids lacking surface architectures, resulting in excellent electrochemical performance in lithium-sulfur (Li−S) batteries. This high-temperature-mediated approach offers new insights for designing hierarchical superstructures and functional materials with enhanced activities.}, archive = {J_ANGEW}, author = {Xie Zhang and Xucheng Lv and Xiangbowen Du and Menghui Qi and Shanjun Mao and Yong Wang}, doi = {10.1002/anie.202423242}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423242}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-temperature-mediated assembly of polyoxometalate-induced ordered carbonaceous superstructures}, volume = {64}, year = {2025}, }
• (2025). 3,6-bis(methylthio)-9H-carbazole based self-assembled monolayer for highly efficient and stable inverted perovskite solar cells. ANGEW, 64(12), e202423206. (www)

  @article{ , abstract = {The photovoltaic performance of inverted perovskite solar cells (PSCs) relies on effectively managing the interface between the hole extraction layer and the light-absorbing perovskite layer. In this study, we have synthesised (4-(3,6-bis(methylthio)-9 H -carbazol-9-yl)butyl)phosphonic acid (MeS-4PACz), which forms a self-assembled monolayer (SAM) on the fluorine-doped tin oxide (FTO) electrode. The molecule‘s methylthio substituents generate a favourable interfacial dipole moment and interact with the perovskite layer. This interaction results in well-aligned energy levels among the FTO/SAM/perovskite layers, promoting efficient hole extraction and significantly reducing carrier recombination losses. Additionally, the methylthio groups passivate iodide vacancies and interact with Pb 2+ ions of the perovskite, reducing defect-induced trap states and enhancing the crystalline growth of the perovskite layer. Consequently, inverted PSCs incorporating MeS-4PACz achieve a power conversion efficiency of 25.13 %, along with outstanding photostability.}, archive = {J_ANGEW}, author = {Shahid Ameen and Dongmin Lee and Abdullah Bin Faheem and Jung Geon Son and Youngwan Lee and Hyunjoon Yoo and Sujung Park and Yun Seop Shin and Jaehwi Lee and Jongdeuk Seo and Hyungsu Jang and Jina Roe and Ji Won Song and Shinuk Cho and Yongsup Park and Kyung-Koo Lee and Jin Young Kim and Dong Suk Kim and BongSoo Kim}, doi = {10.1002/anie.202423206}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423206}, shortjournal = {Angew. Chem. Int. Edit.}, title = {3,6-bis(methylthio)-9H-carbazole based self-assembled monolayer for highly efficient and stable inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Precise supramolecular nanoarchitectonics for simultaneous enhanced photoluminescence and photocatalysis in a co-assembly by a biomimetic isolation-conduction strategy. ANGEW, 64(12), e202423174. (www)

  @article{ , abstract = {Limited by the two mutually exclusive physicochemical processes of separation and recombination of photogenerated carriers, achieving photoluminescence and photocatalysis simultaneously is extremely challenging but essential for ever-growing complex issues and specialized scenarios. Here we proposed a biomimetic isolation-conduction strategy induced by an arene-perfluoroarene (A−P) interaction for enabling photoluminescence and photocatalytic hydrogen evolution reaction (HER) activity in the co-assembly of aromatic monomers and octafluoronapthalene ( OFN ). Inspired by the isolation-conduction effect of periodic isolation of myelin sheaths on the axons of vertebrate nerve fibers by node of Ranvier, we use OFN as a molecular isolator embedded in the aromatic monomers array to block the singlet-to-triplet pathway, while the enlarged intermolecular dipoles resulting from the A−P interactions facilitate the conduction of photogenerated carriers in the isolated regions. The resultant co-assembly exhibits an enhanced monomeric green emission compared to the corresponding monocomponent self-assembly with weak red emission. Meanwhile, it also has an enhanced photocatalytic HER performance with a rate of 2.45 mmol g −1 h −1 , which is 15.2 times more than the self-assembled one. On this basis, a sequential fluoric wastewater reuse system that includes real-time fluorescence detection/removal of perfluorooctanoic acids and photocatalytic HER device is constructed.}, archive = {J_ANGEW}, author = {Zhao Gao and Jianxiang Sun and Lulu Shi and Wei Yuan and Hongxia Yan and Wei Tian}, doi = {10.1002/anie.202423174}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423174}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise supramolecular nanoarchitectonics for simultaneous enhanced photoluminescence and photocatalysis in a co-assembly by a biomimetic isolation-conduction strategy}, volume = {64}, year = {2025}, }
• (2025). Near-infrared light-induced spin-state switching based on Fe(II)−Hg(II) spin-crossover network. ANGEW, 64(12), e202423095. (www)

  @article{ , abstract = {The development of molecular switches with tunable properties has garnered considerable interest over several decades. A novel spin-crossover ( SCO ) material based on iron(II) complexes incorporating 4-acetylpyridine (4-acpy) and [Hg(SCN) 4 ] 2− anions was synthesized and formulated as [Fe(4-acpy) 2 ][Hg( μ -SCN) 4 ] ( 1 ). Compound 1 is crystallized in a three-dimensional network in the non-centrosymmetric orthorhombic space group Pna 2 1 with two octahedral [Fe(4-acpy) 2 (NCS) 4 ] entities featuring two distinct Fe centers (Fe1 and Fe2). Crystallographic, magnetic, and Mössbauer measurements reveal an incomplete SCO exclusively at Fe2, with transition temperature T 1/2 ≈102 K. Photomagnetic studies conducted at 10 K with lasers ranging from 405 to 1310 nm evidence light-induced excited spin-state trapping ( LIESST ) and reverse-LIESST effects, with a unique near-infrared-responsive LIESST phenomenon at 1064 and 1310 nm. Advanced photocrystallographic studies at 40 K provide precise structural evidence for these metastable states. The optical and vibrational properties consistently corroborate with magnetic and photomagnetic studies. Additionally, temperature- and light-dependent terahertz (THz) absorptions are associated with phonon vibrations around Fe2 centers, through SCO behavior, as supported by ab initio calculation. The Fe(II)−Hg(II) systems can be promising benchmarks for exploring synergistic switching effects in structural, magnetic, and spectroscopic properties.}, archive = {J_ANGEW}, author = {Guanping Li and Olaf Stefanczyk and Kunal Kumar and Laurent Guérin and Kosei Okuzono and Kevin Tran and Maximilian Seydi Kilic and Koji Nakabayashi and Kenta Imoto and Asuka Namai and Yuiga Nakamura and Sumit Ranjan Maity and Franz Renz and Guillaume Chastanet and Shin-ichi Ohkoshi}, doi = {10.1002/anie.202423095}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared light-induced spin-state switching based on Fe(II)−Hg(II) spin-crossover network}, volume = {64}, year = {2025}, }
• (2025). Photosynthesis of H2O2 using phenothiazine-based covalent-organic frameworks mimicking coenzyme q. ANGEW, 64(12), e202423055. (www)

  @article{ , abstract = {Mimicking natural enzymes through artificial enzyme engineering represents a powerful strategy to fine-tune the performance of photocatalysts, while the manipulation of electron transfer systems through atomic precision control is challenging. Herein, we reported a series of covalent organic frameworks (COFs) based on progressively oxidized phenothiazine (PTH) core as the platform for emulating Coenzyme Q, achieved through meticulous stepwise adjustments of their redox states. Compared to the original PTH-S-COF , the COFs with incrementally oxidized sulfur sites exhibited enhanced charge transfer efficiencies, facilitating efficient electron donation to O 2 and thereby providing a favorable pathway for H 2 O 2 synthesis. Notably, the PTH-SO 2 -COF achieved a remarkable synthesis rate of 7755 μmol g −1 h −1 , marking a 720 % improvement over the PTH-S-COF baseline. Furthermore, upon adjusting the sacrificial agent ratio, this rate soared to an impressive 13565 μmol g −1 h −1 , surpassing the most reported photo-active COFs. In situ characterizations and simulations verified that three H 2 O 2 evolution pathways (2e − ORR, 4e − OER, and 4e − ORR) all involved in the H 2 O 2 production process. As a result, our findings introduce a novel pathway for the development of high-performance COF-based photocatalysts through the innovative application of artificial enzyme-mimicking techniques.}, archive = {J_ANGEW}, author = {Yaoyao Peng and Lewang Yuan and Kang-Kai Liu and Zong-Jie Guan and Shangbin Jin and Yu Fang}, doi = {10.1002/anie.202423055}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423055}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photosynthesis of H2O2 using phenothiazine-based covalent-organic frameworks mimicking coenzyme q}, volume = {64}, year = {2025}, }
• (2025). Tunable mechanically interlocked semi-crystalline networks. ANGEW, 64(12), e202423029. (www)

  @article{ , abstract = {High-performance polymers based on dynamic chemistry have been widely explored for multi-field advanced applications. However, noncovalent sacrificial bond-mediated energy dissipation mechanism causes a trade-off between mechanical toughness and resilience. Herein, we achieved the synchronous boost of seemingly conflicting material properties including mechanical robustness, toughness and elasticity via the incorporation of mechanical chemistry into traditional semi-crystalline networks. Detailed rheological tests and all-atom molecular dynamics simulation reveal that the excellent mechanical robustness and toughness are attributed to the dissociation of crystalline domains threading through the sieve-shape macrocycles. Reversible nano-crystalline domains and ring-sliding-effect accelerated segment motion efficiently reduce energy dissipation to achieve instantaneous resilience. Moreover, the model polymers demonstrate that the multiple dynamic components endow the resulting polymer with excellent reprocessability under mild conditions. This mechanically interlocked semi-crystalline polymer exhibits potential applications as a thermal/photo actuator. This work reveals the synergic effects of mechanically interlocked sites and tunable crystalline domains, thus providing a reliable guide for the comprehensive improvement of material performance.}, archive = {J_ANGEW}, author = {Wen-Yu Qin and Chen-Yu Shi and Guo-Quan Liu and He Tian and Da-Hui Qu}, doi = {10.1002/anie.202423029}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423029}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tunable mechanically interlocked semi-crystalline networks}, volume = {64}, year = {2025}, }
• (2025). In-situ growth of metallocluster inside heterometal-organic cage to switch electron transfer for targeted CO2 photoreduction. ANGEW, 64(12), e202423018. (www)

  @article{ , abstract = {Construction of metal-organic cages (MOCs) with internal modifications is a promising avenue to build enzyme-like cavities and unlocking the mystery of highly catalytic activity and selectivity of enzymes. However, current interests are mainly focused on single-metal-node cages, little achievement has been expended to metallocluster-based architectures, and the in situ endogenous generation of metal clusters. Herein, based on the hard-soft-acids-bases (HSAB), the metallocluster-based heterometallic MOC ( Cu 3 VMOP ) constructed of [Cu 3 OPz 3 ] + and [V 6 O 6 (OCH 3 ) 9 (SO 4 )(CO 2 ) 3 ] 2− clusters was obtained by one-pot method. In addition, Cu 4 I 4 was generated in situ in the cage to form Cu 4 I 4 @Cu 3 VMOP by the coordination-driven hierarchical self-assembly strategy. As catalysts for CO 2 reduction, Cu 3 VMOP produces HCOOH and CH 3 COOH as the main reduction product with yield of CH 3 COOH up to 0.9 mmol g −1 , ranking among the highest value of reported materials, whereas Cu 4 I 4 @Cu 3 VMOP exhibited targeted CO 2 -to-HCOOH conversion with 100 % formic acid selectivity and the yield outperforms that of Cu 3 VMOP by 5 fold. Theoretical calculations and femtosecond time-resolved transient absorption reveal that endogenous Cu 4 I 4 not only regulates orbital arrangements and enhances localized electron states to generate a long-lived charge-separated state, but also raises *CO coupling energy barrier, resulting in the targeted conversion of CO 2 to formic acid.}, archive = {J_ANGEW}, author = {Yang Yang and Man Dong and Qi Wu and Chao Qin and Weichao Chen and Yun Geng and Shuangxue Wu and Chunyi Sun and Kuizhan Shao and Zhongmin Su and Xinlong Wang}, doi = {10.1002/anie.202423018}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423018}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-situ growth of metallocluster inside heterometal-organic cage to switch electron transfer for targeted CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). BN-acene ladder with enhanced charge transport for organic field-effect transistors. ANGEW, 64(12), e202423002. (www)

  @article{ , abstract = {The in-depth research on the charge transport properties of BN-embedded polycyclic aromatic hydrocarbons (BN-PAHs) still lags far behind studies of their emitting properties. Herein, we report the successfully synthesis of novel ladder-type BN-PAHs ( BCNL1 and BCNL2 ) featuring a highly ordered BC 3 N 2 acene unit, achieved via a nitrogen-directed tandem C−H borylation. Single-crystal X-ray diffraction analysis unambiguously revealed their unique and compact herringbone packing structures. Micro-sized single-crystalline organic field-effect transistors (OFETs) demonstrated that an enhanced charge transport capability, with BCNL2 achieving a hole mobility of up to 0.62 cm 2 V −1 s −1 –three orders of magnitude higher than that of BCNL1 ( μ h max =6 × 10 −4 cm 2 V −1 s −1 ), ranking among the highest values for BN-PAHs-based OFETs. Detailed calculations attribute this significant enhancement in the hole mobility to the marked reduction in reorganization energy ( λ ) of BCNL2 , resulting from the five-membered pyrrole ring annulation and molecular skeleton elongation. This work provides insight into molecular design principles for potential BN-PAHs in optoelectronic applications.}, archive = {J_ANGEW}, author = {Chenglong Li and Yanan Sun and Ning Xue and Yongkang Guo and Ruijun Jiang and Yuanhui Wang and Yujian Liu and Lang Jiang and Xuguang Liu and Zhaohui Wang and Wei Jiang}, doi = {10.1002/anie.202423002}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202423002}, shortjournal = {Angew. Chem. Int. Edit.}, title = {BN-acene ladder with enhanced charge transport for organic field-effect transistors}, volume = {64}, year = {2025}, }
• (2025). A kinetically stabilized dianthraceno[2,3-a:3′,2′-h]-s-indacene: Stable kekulé diradical polycyclic hydrocarbon with triplet ground state. ANGEW, 64(12), e202422994. (www)

  @article{ , abstract = {High-spin polycyclic hydrocarbons (PHs) hold significant potential in organic spintronics and organic magnets. However, their synthesis is very challenging due to their extremely high reactivity. Herein, we report the successful synthesis and isolation of a kinetically blocked derivative ( 1 ) of dianthraceno[2,3- a : 3′,2′- h ]- s -indacene, which represents a rare persistent triplet diradical of a Kekulé PH. Its triplet ground state was unambiguously confirmed by electron paramagnetic resonance and superconducting quantum interference device measurements. Its structure was also unequivocally confirmed through X-ray crystallographic analysis, and its electronic properties were systematically investigated by both experiments and theoretical calculations. The key design principle is to extend the π-conjugation for achieving the decrease of the bonding interaction and the increase of the exchange interaction between unpaired electrons, which are essential for accessing the stable triplet ground state. Due to kinetic blocking, 1 shows a reasonable stability with a half-life time of 64 h under ambient conditions. It has a narrow HOMO–LUMO energy gap and displays amphoteric redox behavior. Notably, its dication and dianion exhibit a closed-shell ground state and near-infrared absorption, and the structures were identified by X-ray crystallographic analysis. This study will shed new light on the design and synthesis of novel stable PHs with high-spin multiplicity.}, archive = {J_ANGEW}, author = {Qing Jiang and Lei Wang and Haipeng Wei and Yuchen Peng and Guangyan Xu and Zhaoyang Li and Pengfei Liu and Zhenni Hu and Weiwei Niu and Yifan Chen and Hui Tang and Wangdong Zeng and Guangwu Li}, doi = {10.1002/anie.202422994}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422994}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A kinetically stabilized dianthraceno[2,3-a:3′,2′-h]-s-indacene: Stable kekulé diradical polycyclic hydrocarbon with triplet ground state}, volume = {64}, year = {2025}, }
• (2025). Organocatalytic asymmetric construction and application of axially chiral spiro-bisindoles. ANGEW, 64(12), e202422951. (www)

  @article{ , abstract = {Spiro skeletons have emerged as a privileged class of chiral carriers across various research fields, including asymmetric catalysis and functional materials, due to their remarkable configurational rigidity. However, limited structural diversity of spiro frameworks significantly restricts the expansion of their applications. Here we present a new class of axially chiral spiro-bisindole frameworks and report their first enantioselective construction via a chiral phosphoric acid-catalyzed intramolecular dehydrative cyclization reaction. Unlike the classical SPINOL backbone, incorporation of indole moieties in place of phenol enhances the nucleophilicity of ketone substrates, thereby eliminating the need for a tedious pre-activation process. By leveraging the retained active sites of indole, the resulting highly enantioenriched spiro-bisindoles can be rapidly transformed into other valuable structures. More importantly, axially chiral fluorescent molecules with good asymmetry factors and quantum fluorescence efficiency are readily accessed, opening a new avenue for developing chiral fluorescent materials. Control experiments demonstrate the pivotal role of both unmasked N−H bonds in achieving good efficiency and enantiocontrol.}, archive = {J_ANGEW}, author = {Hao-Wen Zhao and Fei Jiang and Sihan Chen and Jingliang Hu and Shao-Hua Xiang and Wei-Yi Ding and Wei Lu and Bin Tan}, doi = {10.1002/anie.202422951}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422951}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organocatalytic asymmetric construction and application of axially chiral spiro-bisindoles}, volume = {64}, year = {2025}, }
• (2025). Hybrid enzyme-electrocatalyst cascade modified gas-diffusion electrodes for methanol formation from carbon dioxide. ANGEW, 64(12), e202422882. (www)

  @article{ , abstract = {We propose a hybrid electrocatalytic-bioelectrocatalytic reaction cascade integrated on a gas diffusion electrode for CO 2 reduction under selective formation of methanol. Ag-Bi 2 O 3 selectively reduces gaseous CO 2 to formate at neutral pH conditions. A subsequent enzymatic cascade comprising formaldehyde dehydrogenase and alcohol dehydrogenase, which are both nicotinamide adenine dinucleotide (NAD)-dependent, further reduce formate sequentially to formaldehyde and methanol. The enzymatically oxidized redox cofactor NAD + is regenerated through the enzyme diaphorase which is electrochemically coupled to the electrode by embedding it into a cobaltocene-based low-potential redox polymer. Methanol formation is confirmed using a highly selective biosensor based on alcohol oxidase in combination with horseradish peroxidase integrated into a specifically adapted redox polymer. The proposed hybrid electrocatalytic-bioelectrocatalytic cascade is an example for a general strategy for enhancing the selectivity of electrocatalytic reactions and/or to replace bioelectrochemically challenging steps such as the synthesis of formate from CO 2 using highly oxygen-sensitive formate dehydrogenases by more robust inorganic electrocatalysts.}, archive = {J_ANGEW}, author = {Panpan Wang and Xin Wang and Shubhadeep Chandra and Anna Lielpetere and Thomas Quast and Felipe Conzuelo and Wolfgang Schuhmann}, doi = {10.1002/anie.202422882}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422882}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hybrid enzyme-electrocatalyst cascade modified gas-diffusion electrodes for methanol formation from carbon dioxide}, volume = {64}, year = {2025}, }
• (2025). Rapidly generated, ultra-stable, and switchable photoinduced radicals: A solid-state photochromic paradigm for reusable paper light-writing. ANGEW, 64(12), e202422856. (www)

  @article{ , abstract = {Although photochromic molecules have attracted widespread interest in various fields, solid-state photochromism remains a formidable challenge, owing to the substantial conformational constraints that hinder traditional molecular photoisomerization processes. Benefiting from the significant color change upon radical generation, chemical systems enabling a photoinduced radical (PIR) behavior through photoinduced electron transfer (PET) could be ideal candidates for solid-state photochromism within minimized need of conformational freedom. However, the transient nature of radicals causes a dilemma in this Scheme. Herein, we present a general crystal engineering strategy for rapidly generated (7-s irradiation to saturation) and ultra-stable (lasting 12 weeks) PIRs in the solid state, based on the anti-parallel alignment of para- hydroxyphenyl groups of persulfurated arenes to form a strong non-covalent network for efficient PET and radical stabilization. Using this strategy, a PIR platform was constructed, with a superior photochromic behavior remaining in different solid forms (even in the fully-ground sample) due to their transcendent crystallization ability. On this basis, our compounds can be further processed into reusable papers for light-writing, accompanied by water fumigation for modulating the reversible process. This work provides new insights into addressing solid-state photochromism and can inspire a wide range of optical material design from the switchable radical perspective.}, archive = {J_ANGEW}, author = {Xiaoyan Xu and Ihor Sahalianov and Hao Sun and Zhongyu Li and Shengliang Wu and Boru Jiang and Hans Ågren and Glib V. Baryshnikov and Man Zhang and Liangliang Zhu}, doi = {10.1002/anie.202422856}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422856}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapidly generated, ultra-stable, and switchable photoinduced radicals: A solid-state photochromic paradigm for reusable paper light-writing}, volume = {64}, year = {2025}, }
• (2025). In situ growth of covalent organic frameworks on carbon nanotubes for high-performance potassium-ion batteries. ANGEW, 64(12), e202422851. (www)

  @article{ , abstract = {Redox-active covalent organic frameworks (COFs) have been demonstrated as promising organic electrodes in many electrochemical devices. However, their inherently low conductivity significantly hinders the full utilization of their internal redox-active sites. To address this issue, a simple solvothermal method is used to in situ polymerize 2,4,6-triformylphloroglucinol (TP) and p -phenylenediamine (PA) on the surface of carbon nanotubes (CNTs), generating a nanocable-like COF-based nanocomposite, TpPa-COF@CNT nanocables, which contain abundant β-ketoenamine groups. By combining the high specific surface area and dense active sites of COFs with the superior conductivity of CNTs, the TpPa-COF@CNT nanocables as the anode in potassium-ion batteries displayed excellent performance. The reason is that the isomerization between the enolic and keto forms reinforces the stability of molecular architecture, while the transformation of active sites from C=N to C=O improves the K + adsorption capability. Notably, the TpPa-COF@CNT nanocable anode exhibits a high reversible capacity of 446.1 mAh g −1 at 0.1 A g −1 and maintains 282.5 mAh g −1 even after 2000 cycles at a higher current density of 2.0 A g −1 . Additionally, a full battery assembled with 3,4,9,10-Perylenetetracarboxylic dianhydride heat-treated at 450 °C as the cathode retains a reversible capacity of 273.6 mAh g −1 after 200 cycles at 0.1 A g −1 .}, archive = {J_ANGEW}, author = {Dongbo Yan and Lili Song and Fangyuan Kang and Xiangyin Mo and Yanqi Lv and Jianlu Sun and Haowei Tang and Xiaosi Zhou and Qichun Zhang}, doi = {10.1002/anie.202422851}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422851}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ growth of covalent organic frameworks on carbon nanotubes for high-performance potassium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Unveiling the photoluminescence mechanism of carbonized polymer dots: Evolution and synergistic photoluminescence of multiple molecular fluorophores. ANGEW, 64(12), e202422822. (www)

  @article{ , abstract = {Carbonized polymer dots (CPDs) are a class of exceptional fluorescent materials with diverse applications. However, their photoluminescence (PL) mechanism remained enigmatic and controversial, hindering further development and application. While molecular fluorophores explain primary fluorescence in some CPDs, the overall PL of CPDs still cannot be fully explained, such as their excitation-dependent behaviors, let alone the modulation of PL. Besides, the extracted molecular fluorophores are dissociative, raising questions including the purity of CPDs and whether the PL of CPDs nanoparticles come from these molecular fluorophores. Here, the emission around 510 nm of citric acid-ethylenediamine CPDs (CA-EDA CPDs) was proved to be contributed by a molecular fluorophore, which evolved from another molecular fluorophore following the quantum confinement effect. Further research revealed the whole PL mechanism of CA-EDA CPDs to be the evolution and synergistic PL of multiple molecular fluorophores linked on CPDs nanoparticle. The evolution of molecular fluorophores had also been observed in another two systems, indicating the universality of this mechanism, and a new approach for regulating the optical properties of CPDs was put forward inspired by this mechanism. This study not only refined the PL mechanism but also paved the way for future advancements of CPDs.}, archive = {J_ANGEW}, author = {Xiao Han and Chunlei Xia and Han Wu and Yadian Xie and Rui Li and Bowen Sui and Yue Yu and Bo Wang and Bai Yang}, doi = {10.1002/anie.202422822}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422822}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the photoluminescence mechanism of carbonized polymer dots: Evolution and synergistic photoluminescence of multiple molecular fluorophores}, volume = {64}, year = {2025}, }
• (2025). Breaking performance barriers in KBe2BO3F2 (KBBF) analogs by functional group self-polymerization. ANGEW, 64(12), e202422818. (www)

  @article{ , abstract = {Enhancing the conversion efficiency of all-solid-state lasers through the rational design of crystal materials with superior linear and nonlinear optical (NLO) properties remains a formidable challenge. Herein, we present a novel approach to optimizing these properties in KBe 2 BO 3 F 2 (KBBF)-analog crystals via functional group self-polymerization. This strategy led to the synthesis of two new optical crystals: noncentrosymmetric CsAs 2 O 3 Br and centrosymmetric CsAs 4 O 6 Br. By incorporating highly optically active [AsO 3 ] 3− units into the classical 2D [Be 2 BO 3 F] ∞ − framework, we facilitated the self-assembly of [As 2 O 3 ] ∞ layers, forming a densely packed and highly ordered structure that enhances macroscopic optical activity. CsAs 2 O 3 Br exhibited an extraordinary second-harmonic generation (SHG) response, 20.5 times stronger than KH 2 PO 4 (KDP), while CsAs 4 O 6 Br demonstrated exceptional birefringence (0.26 at 546 nm), setting new performance benchmarks among KBBF analogs. Theoretical analyses reveal that these superior properties arise from the efficient alignment and high density of self-polymerized functional units. This work represents a significant advancement in the design of high-performance UV NLO materials, particularly for fourth-harmonic generation, and paves the way for future innovations in photonic technologies, including solar-blind UV laser systems and advanced photonic devices.}, archive = {J_ANGEW}, author = {Wei Zeng and Yao Tian and Hongmei Zeng and Zhien Lin and Guohong Zou}, doi = {10.1002/anie.202422818}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422818}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking performance barriers in KBe2BO3F2 (KBBF) analogs by functional group self-polymerization}, volume = {64}, year = {2025}, }
• (2025). Reversing surface charge for highly-active organic photovoltaic catalysts. ANGEW, 64(12), e202422779. (www)

  @article{ , abstract = {Organic photovoltaic materials typically exhibit low charge separation and transfer efficiency and severe exciton/carrier recombination due to high exciton binding energy and short exciton diffusion lengths, limiting the enhancement of photocatalytic hydrogen evolution performance. Here, we introduce a surface charge reversal strategy to regulate the charge character of organic photovoltaic catalyst (OPC). Compared to OPC nanoparticles (NPs) stabilized by an anionic surfactant ((−) NPs), NPs stabilized by a cationic surfactant ((+) NPs) exhibit a raised Fermi level, larger surface band bending and Schottky barrier, thereby enhancing charge separation and transfer efficiency while suppressing charge carrier recombination. As a result, (+) NPs demonstrate better photocatalytic performance than (−) NPs, independent of the chemical structure of OPCs and surfactant molecules. Under the illumination of AM1.5G, 100 mW cm −2 , the PM6: 2FBP-4F NPs stabilized by cationic surfactant (dodecyltrimethylammonium bromide, DTAB) exhibit much higher photocatalytic activity for hydrogen evolution (up to 946.1±15.76 mmol h −1 g −1 ) than that of PM6: 2FBP-4F NPs stabilized by anionic surfactant, among the best results reported so far for photocatalytic hydrogen evolution under simulated sunlight.}, archive = {J_ANGEW}, author = {Shichao Wu and Zhenzhen Zhang and Yuhsuan Lee and Yawen Li and Xuefeng Tai and Wenqin Si and Shuming Bai and Yuze Lin}, doi = {10.1002/anie.202422779}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422779}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversing surface charge for highly-active organic photovoltaic catalysts}, volume = {64}, year = {2025}, }
• (2025). Promoting hydrogen transfer in electrochemical CO2 reduction via a hydrogen on demand pathway. ANGEW, 64(12), e202422775. (www)

  @article{ , abstract = {The proceeding of electrochemical CO 2 reduction reaction (CO 2 RR) requires the formation of active hydrogen species for CO 2 protonation, while traditional catalysts fail to balance the rate of hydrogen supply and CO 2 protonation. Herein, we propose a “hydrogen on demand” mechanism, in which the polarity of the adsorbed CO 2 is enhanced to allow the capture of hydrogen from water without forming free hydrogen species, realizing the matching rate of hydrogen supply and CO 2 protonation. As a proof of concept, we construct Zn−N sites modified by Se atoms, allowing the proceeding of CO 2 RR under the “hydrogen on demand” mechanism with superior efficiency. The catalyst achieves an industrial CO current of −539.7 mA cm −2 , faradaic efficiencies of CO >90 % over a broad window from −0.5 to −1.1 V vs. reversible hydrogen electrode and a high turnover frequency of 7.6×10 4 h −1 in flow cell. In situ characterization and theoretical calculations reveal that the introduced Se sites enhance the electron localization around the Zn sites, thus increasing the polarity of adsorbed CO 2 − with improved ability to acquire hydrogen species from water to facilitate the protonation process.}, archive = {J_ANGEW}, author = {Jianfa Chen and Chenghong Hu and Youxia Liu and Yiming Wei and Kui Shen and Liyu Chen and Yingwei Li}, doi = {10.1002/anie.202422775}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422775}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting hydrogen transfer in electrochemical CO2 reduction via a hydrogen on demand pathway}, volume = {64}, year = {2025}, }
• (2025). Catalytic reductive amination and tandem Amination–Alkylation of esters enabled by a cationic iridium complex. ANGEW, 64(12), e202422742. (www)

  @article{ , abstract = {Reported herein is a convenient and efficient method for one-pot, catalytic reductive amination, as well as the first multi-component tandem reductive amination—functionalization of bench-stable and readily available common carboxylic esters. This method is based on the cationic [Ir(COD) 2 ]BArF-catalyzed chemoselective hydrosilylation of esters, followed by one-pot acid-mediated amination and nucleophilic addition. The reaction was conducted under mild conditions at a very low catalyst loading (0.1 mol % of Ir), which could be further reduced to 0.001 mol %, as demonstrated by a reaction at a 15 g scale. The method is highly versatile, allowing the use of esters with or without α- protons for the N- mono-alkylation of primary and secondary amines to produce diverse secondary and tertiary amines, as well as α- branched/functionalized amines. The method is highly chemoselective and tolerates a variety of functional groups such as bromo, trifluoromethyl, ester, and cyano groups. The value of the method was demonstrated by the one-step catalytic synthesis of two bio-relevant N- mono-methyl α- amino esters and the antiparkinsonian agent piribedil, as well as by the use of two shorter chain triglycerides as alkylating feedstock.}, archive = {J_ANGEW}, author = {Guang-Sheng Lu and Zhong-Lei Ruan and Yan Wang and Jin-Fang Lü and Jian-Liang Ye and Pei-Qiang Huang}, doi = {10.1002/anie.202422742}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422742}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic reductive amination and tandem Amination–Alkylation of esters enabled by a cationic iridium complex}, volume = {64}, year = {2025}, }
• (2025). Supercritical ethane processing of ZIF-8 membranes towards pressure-resistant C3H6/C3H8 separation. ANGEW, 64(12), e202422709. (www)

  @article{ , abstract = {ZIF-8 membranes have shown great promise in industrial-scale C 3 H 6 /C 3 H 8 separation. Nonetheless, sustainable preparation of pressure-resistant ZIF-8 membranes remains a grand challenge. In this study, we pioneered the use of supercritical ethane (scC 2 H 6 ) as reaction medium for preparing pressure-resistant ZIF-8 membranes. Membrane growth in neutral organic environment was proven to have less disturbance to structure integrity compared with supercritical CO 2 (scCO 2 ). Gas permeation results indicated that obtained ZIF-8 membrane exhibited an ideal C 3 H 6 /C 3 H 8 selectivity of 172.1 with C 3 H 6 permeance of 5.9×10 −9 mol ⋅ m −2 ⋅ s −1 ⋅ Pa −1 . Of particular note, the membrane maintained stable C 3 H 6 /C 3 H 8 selectivity of ~150 with C 3 H 6 flux of ~1.6×10 −3 mol ⋅ m −2 ⋅ s −1 at operation pressure of 6 bar, which was significantly different from ZIF-8 membranes obtained from scCO 2 reaction medium. Through combining with advantages of zero pollutant discharge and full ligand recovery, our protocol holds great promise in sustainable preparation of pressure-resistant ZIF-8 membranes towards practical application in high-purity C 3 H 6 production.}, archive = {J_ANGEW}, author = {Kunpeng Yu and Taotao Ji and Mingming Wu and Sixing Chen and Yunlei Gao and Jiahui Yan and Shengyan Meng and Wenjing Hu and Xiao Fan and Wenwen Dong and Jianzhong Yin and Yi Liu}, doi = {10.1002/anie.202422709}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422709}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supercritical ethane processing of ZIF-8 membranes towards pressure-resistant C3H6/C3H8 separation}, volume = {64}, year = {2025}, }
• (2025). Exogenously and endogenously sequential regulation of DNA nanodevices enables organelle-specific signal amplification in subcellular ATP profiling. ANGEW, 64(12), e202422651. (www)

  @article{ , abstract = {Adenosine triphosphate (ATP), the primary energy currency in cells, is dynamically regulated across different subcellular compartments. The ATP interplay between mitochondria and endoplasmic reticulum (ER) underscores their coordinated roles in various biochemical processes, highlighting the necessity for precise profiling of subcellular ATP dynamics. Here we present an exogenously and endogenously dual-regulated DNA nanodevice for spatiotemporally selective, subcellular-compartment specific signal amplification in ATP sensing. The system allows for exogenous NIR light-controlled spatiotemporal localization and activation of the aptamer sensor in mitochondria or ER, while a specific endogenous enzyme in the organelles further drives signal amplification via the consumption of molecular beacon fuels, resulting in significantly enhanced sensitivity and spatial precision for the subcellular ATP profiling in the organelle of interest. Furthermore, we demonstrate the application of this system for robust monitoring of ATP fluctuations in mitochondria and ER following drug interventions. This advancement provides a powerful tool for improving our understanding of cellular energetics at the subcellular level and holds potential for the development of targeted therapeutics.}, archive = {J_ANGEW}, author = {Xueyan Feng and Deyu Yi and Lele Li and Mengyuan Li}, doi = {10.1002/anie.202422651}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exogenously and endogenously sequential regulation of DNA nanodevices enables organelle-specific signal amplification in subcellular ATP profiling}, volume = {64}, year = {2025}, }
• (2025). Cephalopod-inspired MXene-integrated mechanochromic cholesteric liquid crystal elastomers for visible-infrared-radar multispectral camouflage. ANGEW, 64(12), e202422636. (www)

  @article{ , abstract = {Multispectral camouflage materials that provide adaptable features across a wide spectrum, from visible light to radar frequencies, play a vital role in sophisticated multi-band electromagnetic (EM) applications. However, conventional single-band stealth is difficult to align with the growing demand for multi-band compatibility and intelligent adaptation. Herein, we report the design and synthesis of cephalopod-inspired MXene-integrated cholesteric liquid crystal elastomers (MXene-CLCEs) with multispectral camouflage capability, which was fabricated through in situ thiol-acrylate Michael addition and free-radical photopolymerization of CLCE precursor and isocyanate-mediated robust covalent chemical bonding of MXene nanocoating at the interface. The resulting MXene-CLCE exhibits dynamic structural color changes, tunable infrared radiation, and switchable microwave shielding across wide ranges upon mechanical stretching, with its infrared stealth and microwave shielding properties being realized through the reconfiguration of surface morphology from planar to cracked states via mechanical actuation. A visible-to-infrared camouflage octopus-patterned MXene-CLCE is demonstrated to achieve a stealth effect across the visible-infrared spectrum upon mechanical stretching. As an illustration, proof-of-concept pneumatic-driven octopus-inspired soft models are demonstrated, which enables dynamic visible-infrared camouflage and microwave shielding switching between two compatible states. The research herein can offer new perspectives on the development of bioinspired smart camouflage materials and their application in various emerging fields such as smart optical stealth, dynamic thermal management, and switchable electromagnetic devices.}, archive = {J_ANGEW}, author = {Yuan Liu and Ran Bi and Xuan Zhang and Yuanhao Chen and Cristian Valenzuela and Yanzhao Yang and Huan Liu and Le Yang and Ling Wang and Wei Feng}, doi = {10.1002/anie.202422636}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422636}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cephalopod-inspired MXene-integrated mechanochromic cholesteric liquid crystal elastomers for visible-infrared-radar multispectral camouflage}, volume = {64}, year = {2025}, }
• (2025). Barrierless electron transfer in a photosynthetic reaction center model. ANGEW, 64(12), e202422633. (www)

  @article{ , abstract = {Vibrational spectroscopy is the ultimate tool to reveal whether any donor-acceptor system is truly delocalized and therefore characterized by a single-welled potential energy surface, or if it is marginally localized with a barrier that defines two minima. Our femtosecond IR absorption investigations on cyanide-bridged mixed valence systems show a broad, intense and downshifted CN vibration signature, revealing, for the first time, an asymmetric, fully delocalized Class III photoinduced mixed valence system.}, archive = {J_ANGEW}, author = {Tobias Ullrich and Ivana Ramírez-Wierzbicki and Leonardo D. Slep and Alejandro Cadranel}, doi = {10.1002/anie.202422633}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422633}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Barrierless electron transfer in a photosynthetic reaction center model}, volume = {64}, year = {2025}, }
• (2025). Striking impact of solvent polarity on the strength of hydrogen-bonded complexes: A nexus between theory and experiment. ANGEW, 64(12), e202422594. (www)

  @article{ , abstract = {The binding free energy of hydrogen-bonded complexes is generally inversely proportional to the solvent dielectric constant. This occurs because the solvent-accessible surface area of the complex is always smaller than that of the individual subsystems, leading to a reduction in solvation energy. The present study explores the potential for stabilizing hydrogen-bonded complexes in a solvent with higher polarity. Contrary to the established understanding, we have demonstrated that the hydrogen-bonded complex (CH 3 CH 2 COOH⋅⋅⋅2,4,6-trimethylpyridine) can be better stabilized in a solvent with higher polarity. In this case, a significant charge transfer between the subsystems results in an increased dipole moment of the complex, leading to its stabilization in a more polar solvent. The expected inverse relationship between binding free energy and solvent dielectric constant is observed when the charge transfer between the subsystems is low. Thus, the magnitude of the charge transfer between subsystems is possibly the key factor in determining the stabilization or destabilization of H-bonded complexes in different solvents. Here, we present a comprehensive study that combines experimental and theoretical approaches, including nuclear magnetic resonance (NMR), infrared (IR) spectroscopies and quantum chemical calculations to validate the findings.}, archive = {J_ANGEW}, author = {Rabindranath Lo and Debashree Manna and Jaroslav Vacek and Petr Bouř and Tao Wu and Zuzana Osifová and Ondřej Socha and Martin Dračínský and Pavel Hobza}, doi = {10.1002/anie.202422594}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422594}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Striking impact of solvent polarity on the strength of hydrogen-bonded complexes: A nexus between theory and experiment}, volume = {64}, year = {2025}, }
• (2025). Anchorable polymers enabling ultra-thin and robust hole-transporting layers for high-efficiency inverted perovskite solar cells. ANGEW, 64(12), e202422571. (www)

  @article{ , abstract = {Currently, the development of polymeric hole-transporting materials (HTMs) lags behind that of small-molecule HTMs in inverted perovskite solar cells (PSCs). A critical challenge is that conventional polymeric HTMs are incapable of forming ultra-thin and conformal coatings like self-assembly monolayers (SAMs), especially for substrates with rough surface morphology. Herein, we address this challenge by designing anchorable polymeric HTMs (CP1 to CP5). Specifically, coordinative pyridyl groups are introduced as side-chains on poly-triarylamine (PTAA) backbone with varied contents by copolymerization method, resulting in chemical interactions between polymeric HTMs and substrates. The strong interaction allows them to be processed into ultra-thin, uniform, and robust hole-transporting layers through employing low-concentration solutions (0.1 mg mL −1 , vs. 2.0–5.0 mg mL −1 for conventional PTAA), greatly decreasing charge transport losses. Moreover, upon systematically tuning the pyridyl substitution ratio, the energy levels, surface wetting, solution processability, and defect passivation capability of such anchorable HTMs are simultaneously optimized. Based on the optimal CP4, we achieved highly efficient inverted PSCs with power conversion efficiencies (PCEs) up to 26.21 %, which is on par with state-of-the-art SAM-based inverted PSCs. Furthermore, these devices exhibit enhanced stabilities under repeated current–voltage scans and reverse bias ageing compared with SAM-based devices.}, archive = {J_ANGEW}, author = {Liqing Zhan and Shuo Zhang and Zhihao Li and Wenzhuo Li and Huidong Zhang and Jingwen He and Xiaoyu Ji and Shuaijun Liu and Furong Yu and Songran Wang and Zhijun Ning and Zhen Li and Martin Stolterfoht and Liyuan Han and Wei-Hong Zhu and Yisheng Xu and Yongzhen Wu}, doi = {10.1002/anie.202422571}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anchorable polymers enabling ultra-thin and robust hole-transporting layers for high-efficiency inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Photochromic dysprosium single-molecule magnet featuring reversible redox transformation of polyoxomolybdate moiety. ANGEW, 64(12), e202422557. (www)

  @article{ , abstract = {A photochromic dysprosium-based single-molecule magnet [Dy(CyPh 2 PO) 2 (H 2 O) 5 ](PMo 12 O 40 ) ⋅ 3CyPh 2 PO⋅H 2 O ( 1-Dy ) is synthesized via cocrystal engineering of a polyoxomolybdate (POMo) anion and an Ising-type cation with pseudo pentagonal bipyramidal geometry. Upon ultraviolet irradiation, Mo VI -to-Mo V single-electron photoreduction occurs in the POMo moiety, resulting in significant changes of optical and magnetic properties. The emergence of intervalence charge-transfer transitions in heteropoly blue state 1-Dy* facilitates photothermal conversion in near-infrared region. Meanwhile, the coercive field of hysteresis loop is altered from 0.72 T ( 1-Dy ) to 0.04 T ( 1-Dy* ) at 2 K, which might be contributed to the magnetic interaction between Dy III and Mo V . After dark treatment, 1-Dy* can convert to the initial state with the recovery of magnetic memory effect. These results presented herein provide a blueprint for developing versatile opto-magnetic materials via the coupling of photochemical regulation and magnetic interaction.}, archive = {J_ANGEW}, author = {Hui Kong and Jing-Yu Wang and Jia-Chuan Liu and Lu Zhang and Pei-Yu Liao and Yu-Quan Qi and Zheng Liu and Si-Guo Wu and Ming-Liang Tong}, doi = {10.1002/anie.202422557}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422557}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photochromic dysprosium single-molecule magnet featuring reversible redox transformation of polyoxomolybdate moiety}, volume = {64}, year = {2025}, }
• (2025). Conformer-mediated helical chirality in 2D layered hybrid perovskites. ANGEW, 64(12), e202422550. (www)

  @article{ , abstract = {Two-dimensional (2D) chiral hybrid perovskites A 2 PbI 4 (A: chiral organic ion) enable chirality controlled optoelectronic and spin-based properties. A + organic sublattice induces chirality into the semiconducting [PbI 4 ] 2− inorganic sublattice through non-covalent interactions at organic–inorganic interface. Often, the A + cations in the lattice have different orientations, leading to asymmetry in the non-covalent interactions. In a novel approach, we use different conformers of A + cations to create asymmetry in the non-covalent interactions, thereby, achieving chiral perovskites with rare helical enantiomorphic structures. We prepared ( R -IdPA) 2 PbI 4 and ( S -IdPA) 2 PbI 4 (IdPA: 1-iodopropan-2-ammonium) which crystallize in the helical enantiomorphic space groups P4 3 2 1 2 and P4 1 2 1 2, respectively. The gauche- and anti-conformers of IdPA + are arranged alternatively in the hybrid structure. Importantly, the anti-conformer of IdPA + ion have significantly stronger electrostatic, N−H⋅⋅⋅I hydrogen bonding, and I⋅⋅⋅I halogen bonding interactions with the [PbI 4 ] 2− sublattice, compared to the gauche-conformer. This periodic asymmetry in non-covalent interactions caused by the alternative arrangement of gauche- and anti-conformers induces chirality in the inorganic sublattice with four-fold screw axes (4 3 and 4 1 ). The enantiomers ( R -/ S -IdPA) 2 PbI 4 show mirror-image like circular dichroism from excitonic absorption of the inorganic sublattice. This conformer-based design of chiral hybrid perovskites in helical space groups broadens material choices for advanced optoelectronic applications.}, archive = {J_ANGEW}, author = {Taniya Dutta and Diptikanta Swain and Angshuman Nag}, doi = {10.1002/anie.202422550}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformer-mediated helical chirality in 2D layered hybrid perovskites}, volume = {64}, year = {2025}, }
• (2025). Arraying and guest inclusion of soluble metal-organic nanotubes composed of macrocyclic paddle-wheel metal complexes. ANGEW, 64(12), e202422546. (www)

  @article{ , abstract = {A new series of metal-organic nanotubes was constructed through one-dimensional assembly using molecular triangles or molecular squares composed of paddlewheel dirhodium complexes and bidentate axial ligands. The metal-organic nanotubes were significantly different from conventional solid metal–organic framework (MOF) motifs. They exhibit good solubility owing to the branched side chains at their periphery and demonstrate high orientation capabilities in thin films owing to their anisotropic structure. Furthermore, the nanotubes can accommodate guest molecules in nanochannels and orient them on a large scale on a glass substrate.}, archive = {J_ANGEW}, author = {Shin-ichiro Kawano and Ako Sasaki and Kentaro Tanaka}, doi = {10.1002/anie.202422546}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422546}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Arraying and guest inclusion of soluble metal-organic nanotubes composed of macrocyclic paddle-wheel metal complexes}, volume = {64}, year = {2025}, }
• (2025). Structure-activity relationships for s-block Metal/Co(III) heterodinuclear catalysts in cyclohexene oxide ring-opening copolymerizations. ANGEW, 64(12), e202422497. (www)

  @article{ , abstract = {In homogeneous catalysis, uncovering structure–activity relationships remains very rare but invaluable to understand and rationally improve performances. Here, generalizable structure–activity relationships apply to a series of heterodinuclear polymerization catalysts featuring Co(III) and s-block metals M(I/II) (M=Na(I), K(I), Ca(II), Sr(II), Ba(II)). These are shown to apply to polycarbonate production by the ring-opening copolymerizations (ROCOP) of cyclohexene oxide (CHO) and carbon dioxide (CO 2 ), conducted at high (20 bar) and low (1 bar) CO 2 pressures, and to polyester production by copolymerization of cyclohexene oxide and phthalic anhydride (PA). For the CHO/PA and high-pressure CHO/CO 2 copolymerizations, activity increases exponentially with s-block metal acidity peaking at the Co(III)K(I) catalyst, whilst for the low-pressure CHO/CO 2 copolymerization it increases linearly to the same metal combination. The polymerization kinetics fit second order rate laws and the correlations support dinuclear metallate mechanistic hypotheses. These relationships help understand and identify key metal complex structural features in synergic polymerization catalysis.}, archive = {J_ANGEW}, author = {Frederica Butler and Francesca Fiorentini and Katharina H. S. Eisenhardt and Charlotte K. Williams}, doi = {10.1002/anie.202422497}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422497}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structure-activity relationships for s-block Metal/Co(III) heterodinuclear catalysts in cyclohexene oxide ring-opening copolymerizations}, volume = {64}, year = {2025}, }
• (2025). Zeolite encapsulation to enhance interfacial gas availability for photocatalytic hydrogen peroxide production. ANGEW, 64(12), e202422495. (www)

  @article{ , abstract = {The photocatalytic oxidation of water with gaseous oxygen is environmentally benign for the synthesis of hydrogen peroxide (H 2 O 2 ), but it is currently constrained by the inadequate supply of gaseous oxygen at the catalyst surface in a solid–liquid–gas triple-phase reaction system. Herein, we address this challenge by employing the zeolite encapsulated catalysts that efficiently enrich gaseous oxygen and accelerate the H 2 O 2 synthesis in aqueous conditions. We focus on the classical titania photocatalyst, encapsulating it within siliceous MFI zeolite crystals. This encapsulation results in a significant enhancement in H 2 O 2 synthesis efficiency, achieving a yield that is ten times greater than that with unencapsulated TiO 2 . Mechanism study reveals that gaseous oxygen is notably concentrated within the microporous structure of the zeolite under aqueous conditions, thereby facilitating its interaction with the titania surface at the liquid-solid interface. In addition, the H 2 O 2 product could swiftly transfer through the micropores, thereby reducing the side reaction of decomposition. This design provides an alternative pathway to address the poor gas solubility of gaseous reactants in water, and paves the way for advancements in various other photocatalytic processes.}, archive = {J_ANGEW}, author = {Bei Cao and Yifeng Liu and Yue Zhao and Jiangshan Qu and Qin Zhou and Fengshou Xiao and Can Li and Liang Wang and Rengui Li}, doi = {10.1002/anie.202422495}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422495}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zeolite encapsulation to enhance interfacial gas availability for photocatalytic hydrogen peroxide production}, volume = {64}, year = {2025}, }
• (2025). High-entropy electrolytes with high disordered solvation structures for ultra-stable zinc metal anodes. ANGEW, 64(12), e202422395. (www)

  @article{ , abstract = {Aqueous zinc-ion batteries (ZIBs) are playing an increasingly important role in the field of energy storage owing to their low cost, high safety, and environmental friendliness. However, their practical applications are still handicapped by severe dendrite formation and side reactions (e.g., hydrogen evolution reaction and corrosion) on the zinc anodes. Herein, a low-concentration high-entropy (HE) electrolyte strategy is proposed to achieve high reversibility and ultra-durable zinc metal anode. Specifically, this HE electrolyte features multiple anions participating in coordination and highly disordered solvation shells, which would disrupt the intrinsic H-bond network between water molecules and suppress interfacial side reactions. Moreover, these diversified weakly solvated structures can lower the solvation energy of Zn 2+ solvation configurations and enhance zinc ion diffusion kinetics, thereby promoting uniform Zn deposition and electrode interface stability. Consequently, Zn||Zn symmetric cells exhibit over 2,000 hours of cycling stability, and Zn||Cu asymmetric cells achieve a high average Coulombic efficiency of 99.9 % over 500 cycles. Furthermore, the Zn||PANI full cell with the optimized HE-50 mM electrolyte delivers a high specific capacity of 110.7 mAh g −1 over 2,000 cycles at 0.5 A g −1 and a capacity retention of 70.4 % at 15 A g −1 after 10,000 cycles. Remarkably, even at a low temperature of −20 °C, the Zn||PANI full cells equipped with HE-50 mM electrolyte still demonstrate long-term cycling stability over 600 cycles with a high-capacity retention of 93.5 %. This research provides a promising strategy for the design of aqueous electrolytes, aiding in the development of low-cost, high-safety, and high-performance aqueous batteries.}, archive = {J_ANGEW}, author = {Haoran Wang and Shenzhen Deng and Shuai Wang and Wulong Li and Shixing Yuan and Jing Han and Hongyan Fu and Bingang Xu and Lei Wei}, doi = {10.1002/anie.202422395}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422395}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy electrolytes with high disordered solvation structures for ultra-stable zinc metal anodes}, volume = {64}, year = {2025}, }
• (2025). Cascade reaction enables heterointerfaces-enriched nanoarrays for ampere-level hydrogen production. ANGEW, 64(12), e202422393. (www)

  @article{ , abstract = {Designing high-performance electrocatalysts with superior catalytic activity and stability is essential for large-scale hydrogen production via water electrolysis. Heterostructure nanoarrays are promising candidates, though achieving both high activity and stability simultaneously, especially under high current densities, remains challenging. To this end, we have developed a cascade reaction process that constructs a series of heterostructure nanoarrays with rich heterointerfaces. This process involves treating nickel foam (NF) with molten KSCN and transition metal salts. Initially, NF reacts with KSCN to form Ni 9 S 8 nanoarrays and S 2− ions, which are subsequently captured by transition metal ions to form sulfides that are directly integrated onto the nanoarrays, resulting in abundant heterointerfaces. Both experimental and theoretical results indicate that these rich heterointerfaces significantly enhance the interfacial interaction between Ni 9 S 8 and RuS 2 within the nanoarrays (termed RH-Ni 9 S 8 /RuS 2 ), markedly improving both the intrinsic activity and stability for the hydrogen evolution reaction (HER). Impressively, the RH-Ni 9 S 8 /RuS 2 demonstrates exceptional HER performance, achieving a low overpotential of just 180 mV at 1000 mA cm −2 and maintaining stability for up to 500 h under such high-current-density conditions. This innovative approach paves the way for the interfacial design and synthesis of high-performance catalysts for ampere-level hydrogen production.}, archive = {J_ANGEW}, author = {Hongfang Du and Song He and Boxin Li and Ke Wang and Zhenkai Zhou and Junhui Li and Tingfeng Wang and Zhuzhu Du and Wei Ai and Wei Huang}, doi = {10.1002/anie.202422393}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422393}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cascade reaction enables heterointerfaces-enriched nanoarrays for ampere-level hydrogen production}, volume = {64}, year = {2025}, }
• (2025). One-step process for the regiodivergent double hydrocyanation of 1,3-butadiene. ANGEW, 64(12), e202422337. (www)

  @article{ , abstract = {In industry, the two important nitrile starting materials, adiponitrile and 2-methylglutaronitrile, are primarily manufactured through the well-known DuPont process, which consists of a tandem sequence including first hydrocyanation, isomerization and second hydrocyanation. However, this mature process has the intrinsic defects of step efficiency and regioselectivity. Herein, we report a nickel-catalyzed divergent, one-step double hydrocyanation of 1,3-butadiene to produce either adiponitrile or 2-methylglutaronitrile in high regioselectivity. The key to this success lies in the highly tunable binding pockets of the bidentate phosphite ligands, which creates a geometrically defined coordination space around the nickel center. The first hydrocyanation that produces either the linear or branched alkenyl nitrile was identified as the selectivity-determining step. Organometallic studies confirm the formation of well-defined diphosphite nickel diene complexes in solution, and the role of ligands in dictating regioselectivity was further rationalized by DFT computations. This result provides the first example of a highly selective nickel-catalyzed synthesis of adiponitrile and 2-methylglutaronitrile from butadiene, and it also represents a high-level of catalyst-controlled regioselectivity via the fine-tuning of ligand pocket geometry.}, archive = {J_ANGEW}, author = {Jinguo Long and Ting Wang and Hongyu Zhong and Mingdong Jiao and Bill Morandi and Lin He and Gui-Juan Cheng and Xianjie Fang}, doi = {10.1002/anie.202422337}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422337}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-step process for the regiodivergent double hydrocyanation of 1,3-butadiene}, volume = {64}, year = {2025}, }
• (2025). Temperature-swing synthesis of highly crystalline covalent organic framework films for fast and precise molecular separations. ANGEW, 64(12), e202422333. (www)

  @article{ , abstract = {Producing crystalline covalent organic framework (COF) films is intimately related to the elusive nucleation and growth processes, which is desirable for efficient molecular transport. Rational control over these processes and insights into the mechanisms are crucial to improve synthetic methodology and achieve COF films with regular channels. Here, we report the controllable synthesis of COF films via the temperature-swing strategy and explore their crystallization from monomer assemblies to film formation. A detailed time-dependent study reveals that COF crystallites preferentially coalesce at low temperature, progressing from assembled nanospheres to continuous films through lateral and vertical interactions. Moreover, appropriately elevating the synthesis temperature promotes crystal growth and eliminate the defects of weakly crystalline regions, contributing to highly crystalline and porous COF film with a surface area of 746 m 2 g −1 . The prepared COF composite membrane exhibits a methanol permeance of 79 L m −2 h −1 bar −1 , which is 4.5 times higher than the weakly crystalline counterpart. In addition, the molecular sieving test recognize great membrane selectivity to discriminate the antibiotic mixture with a high separation factor of 15.4. This work offers a feasible way for the rational design of the synthesis environment, enabling access to highly crystalline framework materials for targeting molecular separations.}, archive = {J_ANGEW}, author = {Kai Liu and Congcong Yin and Jinglin Gao and Yong Wang}, doi = {10.1002/anie.202422333}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422333}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Temperature-swing synthesis of highly crystalline covalent organic framework films for fast and precise molecular separations}, volume = {64}, year = {2025}, }
• (2025). Achieving high Solid–Liquid ratio through competitive coordination towards efficient recovery of metals from spent batteries. ANGEW, 64(12), e202422313. (www)

  @article{ , abstract = {The recycling of critical metals from spent lithium-ion batteries represents a significant step towards meeting the enhancing resource requirements in the new energy industry. Nevertheless, achieving effective leaching of metals from the stable metal-oxygen (MO 6 ) structure of spent ternary cathodes and separation of metal products simultaneously still remained a huge challenge towards industrial applications. Herein, a competitive coordination strategy was proposed to design a novel deep eutectic solvent (DESs), which improved both leaching and selective metal recycling capacity even at high solid–liquid ratio (1 : 10). The results demonstrated that the number of hydrogen bonds in designed ternary DESs was 16.5 % higher compared to those in the binary DESs, resulting in efficient reaction kinetics to break the metals-oxygen bond. More importantly, the competing-ligand (p-toluenesulfonic acid) could preferentially enter into the first nanostructure sheath and reduce the proportion of solvated oxalic acid (OxA) from 28.36 % to 17.76 % within the nanostructure, which enable OxA molecules to enhance the coordination interaction with metal for precipitating NiC 2 O 4 ⋅ 2H 2 O product (~95.7 % purity) from spent cathodes. This work achieved impressive profitability ($16.05 per kg feedstock) and effectively reduction of GHG emissions during the recycling process, making it applicable to critical sustainability initiatives.}, archive = {J_ANGEW}, author = {Jing Tan and Rui Huang and Kunpeng Li and Xu Yan and Lin Guo and Zaiping Guo and Wenchao Zhang and Liyuan Chai}, doi = {10.1002/anie.202422313}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422313}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving high Solid–Liquid ratio through competitive coordination towards efficient recovery of metals from spent batteries}, volume = {64}, year = {2025}, }
• (2025). Extended tetrathiafulvalene multi-redox systems incorporating 4,5-dihydroazuleno[2,1,8-ija]azulene cores. ANGEW, 64(12), e202422275. (www)

  @article{ , abstract = {The introduction of 4,5-dihydroazuleno[2,1,8- ija ]azulene as a central core between two 1,4-dithiafulvene (DTF) units provides a novel class of extended tetrathiafulvalene (TTF) electron donors. Herein we present the synthesis of such compounds with the azulenoazulene further expanded by annulation to benzene, naphthalene, or thiophene rings. Moreover, unsymmetrical donor-acceptor chromophores with one DTF and one carbonyl at the central core are presented. The effect of the odd-membered rings of the polycyclic aromatic hydrocarbon cores on the geometrical features and the extent of bond conjugation in these systems were investigated by UV/Vis absorption spectroscopy, (spectro)electrochemical studies, X-ray and electron diffraction, and computational studies. Altogether these studies reveal that, upon oxidation, the non-planar core of the bis(benzo)-fused dihydro-azulenoazulene-extended TTF generates a large 22π-aromatic system (together with two 6π-aromatic 1,3-dithiolium appendages) characterized by significant bond length equalizations. The dication formed by oxidation is EPR silent, indicating a singlet ground state. Computations reveal that the closed-shell singlet species and its open-shell singlet counterpart are nearly degenerate and of lower energy than a triplet species. According to cyclic voltammetry, the compounds can be oxidized further and present multi-redox systems.}, archive = {J_ANGEW}, author = {Viktor Bliksted Roug Pedersen and Michal Zalibera and Frédéric Lirette and Jérémie Ouellette and Arianna Lanza and Israel Fernández and Peter Rapta and Jean-François Morin and Mogens Brøndsted Nielsen}, doi = {10.1002/anie.202422275}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422275}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Extended tetrathiafulvalene multi-redox systems incorporating 4,5-dihydroazuleno[2,1,8-ija]azulene cores}, volume = {64}, year = {2025}, }
• (2025). Latent solvent-induced inorganic-rich interfacial chemistry to achieve stable potassium-ion batteries in low-concentration electrolyte. ANGEW, 64(12), e202422259. (www)

  @article{ , abstract = {Low-concentration electrolytes (LCEs) have attracted great attention due to their cost effectiveness and low viscosity, but suffer undesired organic-rich interfacial chemistry and poor oxidative stability. Herein, a unique latent solvent, 1,2-dibutoxyethane (DBE), is proposed to manipulate the anion-reinforced solvation sheath and construct a robust inorganic-rich interface in a 0.5 M electrolyte. This unique solvation structure reduces the desolvation energy, facilitating rapid interfacial kinetics and K + intercalation in graphite. Additionally, enhanced anion-cation interactions promote the formation of a thin and robust interfacial layer with excellent cycling performance of potassium-ion batteries (PIBs). Graphite||perylene-3,4,9,10-tetracarboxylic dianhydride full cell exhibits a good capacity retention of 80.3 % after 300 cycles, and delivers a high discharge capacity of 131.3 mAh g −1 even at 500 mA g −1 . This study demonstrates the feasibility of latent solvent-optimized electrolyte engineering, providing a pathway of superior electrochemical energy storage in PIBs.}, archive = {J_ANGEW}, author = {Qian Yang and Xunzhu Zhou and Tingting Huang and Zhuo Chen and Yu Zhang and Shuo Shi and Wen Zhang and Lin Li and Jiazhao Wang and Shixue Dou and Kaixiang Lei and Shijian Zheng}, doi = {10.1002/anie.202422259}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Latent solvent-induced inorganic-rich interfacial chemistry to achieve stable potassium-ion batteries in low-concentration electrolyte}, volume = {64}, year = {2025}, }
• (2025). Through space π-electrons communication in [2,2]-paracyclophanes: Unprecendented stabilization of radicals. ANGEW, 64(12), e202422253. (www)

  @article{ , abstract = {Efforts to understand radical stability have led to considerable progress in radical chemistry. In this article, we investigated a novel approach to enhancing the radical stability of carbon-centered radicals through space electron delocalization within [2,2]-paracyclophanes. Alkoxyamines possessing a paracyclophane scaffold exploit face-to-face π-π-interactions between the aromatic rings to effectively lower bond dissociation energy (BDE) for NO−C bond homolysis. Electron spin resonance (ESR) experiments and computational modeling have confirmed a better stability compared to the analogues without the paracyclophane core. Theoretical analyses further elucidate the role of through-space electron communication in enhancing radical stability. This study highlights promising applications in fields such as organic synthesis, material science, and drug design. By achieving a low BDE for homolysis, the alkoxyamines efficiently release radicals, enabling successful application in nitroxide-mediated polymerization (NMP) of styrene, which provides high control over polymer architecture. Additionally, preliminary anti-proliferative assays reveal that the alkoxyamines exhibit promising anti-cancer activities against lung, breast, and prostate cells, which is correlated to their ability to release radicals upon homolysis.}, archive = {J_ANGEW}, author = {Eléa Fauvel and Tataye Moussounda Moussounda Koumba and Firas El Kadiry and Sébastien Maria and Marion Rollet and Marc Maresca and Didier Siri and Jean-Louis Clément and Didier Gigmes and Malek Nechab}, doi = {10.1002/anie.202422253}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422253}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Through space π-electrons communication in [2,2]-paracyclophanes: Unprecendented stabilization of radicals}, volume = {64}, year = {2025}, }
• (2025). Divergent oxidation reactions of E- and Z-allylic primary alcohols by an unspecific peroxygenase. ANGEW, 64(12), e202422241. (www)

  @article{ , abstract = {Unspecific peroxygenases (UPOs) catalyze the selective oxygenation of organic substrates using only hydrogen peroxide as the external oxidant. The PaDa−I variant of the UPO from Agrocybe aegerita catalyses the oxidation of Z - and E -allylic alcohols with complementary selectivity, giving epoxide and carboxylic acid/aldehyde products respectively. Both reactions can be performed on preparative scale with isolated yields up to 80 %, and the epoxidations proceed with excellent enantioselectivity (>99 % ee ). The divergent reactions can also be used to transform E / Z mixtures of allylic alcohols, enabling both product series to be isolated from a single reaction. The utility of the epoxidation method is exemplified in the total synthesis of both enantiomers of the insect pheromone disparlure, including a highly enantioselective gram-scale transformation. These reactions provide further evidence for the potential of UPOs as catalysts for the scalable preparation of important oxygenated intermediates.}, archive = {J_ANGEW}, author = {Jiacheng Li and Cristina Duran and Balázs Pogrányi and Katy A. S. Cornish and Jared Cartwright and Sílvia Osuna and William P. Unsworth and Gideon Grogan}, doi = {10.1002/anie.202422241}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422241}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent oxidation reactions of E- and Z-allylic primary alcohols by an unspecific peroxygenase}, volume = {64}, year = {2025}, }
• (2025). Reaction-diffusion and crystallization kinetics modulation of two-step deposited tin-based perovskite film via reducing atmosphere. ANGEW, 64(12), e202422217. (www)

  @article{ , abstract = {The two-step deposition method effectively mitigates the efficiency decline observed in tin-based perovskite solar cells (TPVSCs) with increasing cell area, stemming from film in-homogeneity. However, the high solubility of SnI 2 in the conventionally used solvent isopropyl alcohol, coupled with the absence of effective modulation of reaction-diffusion process, results in inadequate film coverage and conversion. In this study, we introduce formic acid as the second-step solvent and introduce dithiothreitol (DTT) to regulate reaction-diffusion/crystallization kinetics meticulously. Moreover, this research underscores a fundamental principle that the suitable binding energy ranging from −1.38 to −10.10 kcal mol −1 between ligands and Sn 2+ significantly enhances the effectiveness of two-step crystallization control. Notably, a uniform perovskite film is achieved on large-scale substrate, and TPVSCs processed with DTT exhibit the highest efficiencies of 12.68 % for 0.04 cm 2 device and 11.30 % for 1 cm 2 device among tin-based perovskite devices in two-step sequential deposition method, even in the absence of dimethyl sulfoxide. This study lays the groundwork for the potential scale-up development of lead-free perovskite solar cells.}, archive = {J_ANGEW}, author = {Hongbo Zhou and Wangping Sheng and Huan Rao and Yang Su and Wenjian Zhu and Yang Zhong and Yikun Liu and Jiacheng He and Licheng Tan and Yiwang Chen}, doi = {10.1002/anie.202422217}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422217}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reaction-diffusion and crystallization kinetics modulation of two-step deposited tin-based perovskite film via reducing atmosphere}, volume = {64}, year = {2025}, }
• (2025). Optimizing s–p orbital overlap between sodium polysulfides and single-atom indium catalyst for efficient sulfur redox reaction. ANGEW, 64(12), e202422208. (www)

  @article{ , abstract = {P- block metal carbon-supported single-atom catalysts (C-SACs) have emerged as a promising candidate for high-performance room-temperature sodium-sulfur (RT Na−S) batteries, due to their high atom utilization and unique electronic structure. However, the ambiguous electronic-level understanding of Na-dominant s-p hybridization between sodium polysulfides (NaPSs) and p- block C-SACs limits the precise control of coordination environment tuning and electro-catalytic activity manipulation. Here, s-p orbital overlap degree (OOD) between the s orbitals of Na in NaPSs and the p orbitals of p- block C-SACs is proposed as a descriptor for sulfur reduction reaction (SRR) and sulfur oxidation reaction (SOR). Compared to NG and NG-supported InN 4 (NG-InN 4 ) SACs, the nitrogen-doped graphene-supported InN 5 (NG-InN 5 ) SACs show the largest s-p OOD, demonstrating the weakest shuttle effect and the lowest reaction energy barriers in both SRR and SOR. Accordingly, the designed catalysts allow the Na−S pouch batteries to retain a high capacity of 490.7 mAh g −1 at 2 A g −1 with a Coulombic efficiency of 96 % at a low electrolyte/sulfur (E/S) ratio of 4.5 μl mg −1 . This work offers an s-p orbital overlap descriptor describing the interaction between NaPSs and p- orbital-dominated catalysts for high-performance RT Na−S batteries.}, archive = {J_ANGEW}, author = {Guangxuan Wu and Tongfeng Liu and Zhoujie Lao and Yihao Cheng and Tianshuai Wang and Jing Mao and Haichang Zhang and Enzuo Liu and Chunsheng Shi and Guangmin Zhou and Chunnian He and Wenbin Hu and Naiqin Zhao and Ningning Wu and Biao Chen}, doi = {10.1002/anie.202422208}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422208}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimizing s–p orbital overlap between sodium polysulfides and single-atom indium catalyst for efficient sulfur redox reaction}, volume = {64}, year = {2025}, }
• (2025). Sub-nanometer pt nanowires with disordered shells for highly active electrocatalytic oxidation of formic acid. ANGEW, 64(12), e202422199. (www)

  @article{ , abstract = {Controlled synthesis of one-dimensional materials at atomic-scale dimensions represents a milestone in nanotechnology, offering the potential to maximize atom utilization while enhancing catalytic performance. However, achieving structural stability and durability at such fine scales requires precise control over material structure and local chemical environment. Here, we introduce dimethylamine (DMA) as a small-molecule modifier, in contrast to conventional long-chain surfactants, to interact with surface Pt atoms. This approach facilitates the removal of surface Pt atoms bonded to nitrogen atoms in DMA during solubilization in water, effectively stripping the size of Pt nanowires down to sub-nanometer. The resulting Pt subnanometer nanowires (subNWs) feature a monoatomic-layer surface composed of disordered, bonding-unsaturated Pt atoms, and an interior crystalline core as narrow as 0.58 nm in diameter. These unique structural characteristics confer the Pt subNWs with an electrochemically active surface-area of 189 m 2 ⋅ g −1 during formic acid oxidation. Furthermore, the amorphous-like surface structure lowers the free energy of *OCOH intermediates and inhibits the formation of toxic byproducts CO, demonstrating exceptional electrocatalytic activity of 18.1 A ⋅ mg −1 , surpassing most reported Pt-based electrocatalysts. Our work introduces a novel strategy for the controlled construction of nanowire-structures at sub-nanometer scale, effectively bridging the gap between ultrafine structural design and performance stability.}, archive = {J_ANGEW}, author = {Gui Liu and Ruichun Luo and Junhao Ma and Tianqi Guo and Jianxin Kang and Wenxiong Shi and Wu Zhou and Lin Guo}, doi = {10.1002/anie.202422199}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422199}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sub-nanometer pt nanowires with disordered shells for highly active electrocatalytic oxidation of formic acid}, volume = {64}, year = {2025}, }
• (2025). Synthesis of arenesulfenyl fluorides and fluorosulfenylation of alkenes, alkynes, and α-diazocarbonyl compounds. ANGEW, 64(12), e202422120. (www)

  @article{ , abstract = {Sulfenyl fluorides are organic compounds of sulfur in formal oxidation state +2 with the formula R−S−F. Although the chloride, bromide, and iodide analogues have been extensively described in the literature, arenesulfenyl fluorides remain essentially unstudied. These structures have been implicated as putative intermediates in established processes to access polyfluorinated sulfur species; however, definitive and direct evidence of their existence has not been obtained, nor has a systematic understanding of their reactivity. Here, we report the synthesis, isolation, and spectroscopic characterization of several arenesulfenyl fluorides, including structural analysis of 2,4-dinitrobenzenesulfenyl fluoride and 4-cyano-2-nitrobenzenesulfenyl fluoride by single-crystal X-ray diffraction. The functional group undergoes direct, efficient, and highly regioselective anti -addition to alkenes and alkynes, as well as insertion by carbenes. The resulting α- or β-fluoro thioether adducts can be readily transformed into useful fluorinated motifs, for example by modification of the sulfur groups (to sulfonamides or sulfonyl fluorides), by sulfur elimination (to generate formal C−H fluorination products), or by Julia–Kocienski olefination (to form vinyl fluorides). Thus, we establish that sulfenyl fluorides are unexpectedly accessible and stable compounds, which serve as versatile reagents for the production of fluorinated organic compounds.}, archive = {J_ANGEW}, author = {Nathan H. Faialaga and Dana P. Gephart and Breno D. Silva and Richard Y. Liu}, doi = {10.1002/anie.202422120}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422120}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of arenesulfenyl fluorides and fluorosulfenylation of alkenes, alkynes, and α-diazocarbonyl compounds}, volume = {64}, year = {2025}, }
• (2025). Bulk stereoselective cationic polymerization of vinyl ethers by the coordination of ZrCl4 with tunable spirocyclic phosphoric acids. ANGEW, 64(12), e202422085. (www)

  @article{ , abstract = {Control over stereochemistry in poly(vinyl ether)s leads to a notable change in their physical properties, yet remains a grand challenge. Here, we demonstrate the bulk stereoselective cationic polymerization of vinyl ethers using ZrCl 4 coordinated with a spirocyclic phosphoric acid (SPA). The widely variable substituents in SPAs exert a profound impact on the stereochemical and activity outcome of the polymerization: the % m of poly(vinyl ether)s linearly increases with the Hammett substituent constant (σ) of SPAs; the catalytic activity increases with the σ; the large steric hindrance groups lead to decreased polymerization activity. Mechanism studies suggest that the coordination of ZrCl 4 with three equivalents of SPAs generates the chiral complex. The complex can abstract chlorine from the initiator/chain end to form the chiral ion pair allowing the selective facial addition of incoming monomers. The catalyst system features characteristics of no solvent, low loads, high tacticity control, high monomer scope, and recyclability.}, archive = {J_ANGEW}, author = {Yinong Wu and Xiong Liu and Chengjian Zhang and Xinghong Zhang and Xufeng Lin}, doi = {10.1002/anie.202422085}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bulk stereoselective cationic polymerization of vinyl ethers by the coordination of ZrCl4 with tunable spirocyclic phosphoric acids}, volume = {64}, year = {2025}, }
• (2025). Constraining CO2 coverage on copper promotes CO2 electroreduction to multi-carbon products in strong acid. ANGEW, 64(12), e202422082. (www)

  @article{ , abstract = {Electrocatalytic CO 2 reduction (CO 2 R) to multi-carbon (C 2+ ) products in strong acid presents a promising approach to mitigate the CO 2 loss commonly encountered in alkaline and neutral systems. However, this process often suffers from low selectivity for C 2+ products due to the competing C 1 (e.g., CO and HCOOH) formation and complex C−C coupling kinetics. In this work, we report a CO 2 coverage constraining strategy by diluting CO 2 reactant feed to modulate the intermediate distribution and C−C coupling pathways for an enhanced electrosynthesis of C 2+ products in strong acid. Lowering the CO 2 feed concentration reduces CO 2 coverage on copper catalyst, enriching the surface coverage and optimizing the adsorption configuration of the key CO intermediate for C−C coupling. This approach efficiently suppresses the formation of undesired C 1 products. By employing a 20 % CO 2 feed, we achieved a significant improvement in C 2+ Faradaic efficiency, reaching 68 % at 100 mA cm −2 , approximately 1.7 times higher than the 41 % obtained using pure CO 2 . We demonstrated the direct electroreduction of a 30 % CO 2 feed—representative CO 2 concentration of typical industrial flue gases—in a full electrolyzer, achieving a C 2+ selectivity of 78 % and an energy efficiency of 23 % at 200 mA cm −2 .}, archive = {J_ANGEW}, author = {Wanfeng Yang and Yong Zhao and Yiqing Chen and Hangjuan Ren and Jiameng Sun and Zhangsheng Shi and Xindie Jin and Zhonghua Zhang and Xin Wang}, doi = {10.1002/anie.202422082}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422082}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constraining CO2 coverage on copper promotes CO2 electroreduction to multi-carbon products in strong acid}, volume = {64}, year = {2025}, }
• (2025). Beyond dimerization: Harnessing tetrameric coiled-coils for nanostructure assembly. ANGEW, 64(12), e202422075. (www)

  @article{ , abstract = {Versatile DNA and polypeptide-based structures have been designed based on complementary modules. However, polypeptides can also form higher oligomeric states. We investigated the introduction of tetrameric modules as a substitute for coiled-coil dimerization units used in previous modular nanostructures. Tetramerizing helical bundles can run in parallel or antiparallel orientation, expanding the number of topological solutions for modular nanostructures. Furthermore, this strategy facilitates the construction of nanostructures from two identical polypeptide chains. Importantly, tetrameric modules substantially stabilized protein nanostructures against air–water interface denaturation, enabling the determination of the first cryo-electron microscopy three-dimensional structure of a coiled-coil-based nanostructure, confirming the designed agreement of the modules forming a tetrahedral cage.}, archive = {J_ANGEW}, author = {Sara Vidmar and Tamara Šmidlehner and Jana Aupič and Žiga Strmšek and Ajasja Ljubetič and Fei Xiao and Guang Hu and Chuan Liu and Florian Beck and Philipp S. Erdmann and Roman Jerala}, doi = {10.1002/anie.202422075}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422075}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Beyond dimerization: Harnessing tetrameric coiled-coils for nanostructure assembly}, volume = {64}, year = {2025}, }
• (2025). Molecular conjugated-polymer electrode enables rapid proton conduction for electrosynthesis of ammonia from nitrate. ANGEW, 64(12), e202422072. (www)

  @article{ , abstract = {Electrosynthesis of ammonia (NH 3 ) from nitrate (NO 3 − ) using renewable energy holds promise as a supplementary alternative to the Haber−Bosch process for NH 3 production. Most research focuses on tuning the catalytic activity of metal catalysts by modification of the catalyst structures. However, the electrode supports which could influence the catalytic activity have not been well-explored. The state-of-the-art electrocatalysts for NO 3 − reduction to NH 3 still exhibit limited energy efficiency at ampere-level current density. Herein, we report a polyaniline-based molecular electrode with Cu catalyst for selective and energy-efficient NO 3 − reduction to NH 3 . In the electrode, the polyaniline promotes protonation of the key intermediate formed during NO 3 − reduction at Cu, which circumvents the limitation of the Cu catalyst in the efficiency-limiting proton transfer step. The molecular electrode produces NH 3 at a partial current density of 2.7 A cm −2 with an energy efficiency of 62 %, demonstrating much better electrochemical performance than common Cu-based electrocatalysts and indicating the great potential in molecular engineering of electrode supports for selective NO 3 − reduction.}, archive = {J_ANGEW}, author = {Xinhao Su and Feiyang Hong and Yanjie Fang and Yingke Wen and Bing Shan}, doi = {10.1002/anie.202422072}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422072}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular conjugated-polymer electrode enables rapid proton conduction for electrosynthesis of ammonia from nitrate}, volume = {64}, year = {2025}, }
• (2025). Engineering electrolyte network structure for improved kinetics and dendrite suppression in zn-S batteries. ANGEW, 64(12), e202422047. (www)

  @article{ , abstract = {Aqueous zinc-sulfur batteries (Zn−S) are promising alternatives to conventional lithium-ion technology due to their high energy density, low cost, and enhanced safety. However, challenges such as slow redox kinetics of sulfur cathode conversion and inadequate anode stability persist. This study demonstrates that by tuning the electrolyte structure with the introduction of propylene glycol methyl ether (PM) as a co-solvent and ZnI 2 as an electrolyte additive, and significant improvements at both electrodes could be achieved. Experimental and theoretical calculations reveal that the larger polar −OH and C−O−C electron-donating groups in the PM molecule can donate electrons for the redox reaction of I − /I 3 − . Its role as a redox mediator improves the reversibility of the sulfur cathodic transformation. Additionally, the dipole moment induced by the hydroxyl groups in PM enhances electron transfer from the zinc anode to the electrolyte and promote the decomposition of anions (OTF − ), improving the interfacial stability of the zinc anode. The synergistic effect of PM and the I − /I 3 − redox mediator pair enables the zinc-sulfur battery to deliver an impressive capacity of 1456 mAh g −1 and a high energy density of 471.8 Wh kg −1 at a current density of 0.2 A g −1 .}, archive = {J_ANGEW}, author = {Yinfeng Guo and Xiaoqing Zhu and Jia Zhang and Tao Zhang and Zilong Wang and Minghui Shan and Fei Wang and Changyong Chase Cao and Guiyin Xu and Meifang Zhu}, doi = {10.1002/anie.202422047}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422047}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering electrolyte network structure for improved kinetics and dendrite suppression in zn-S batteries}, volume = {64}, year = {2025}, }
• (2025). Cell-specific control of mammalian gene expression using DNA repair inducible ribozyme switches. ANGEW, 64(12), e202422042. (www)

  @article{ , abstract = {The ability to control gene expression is vital for elucidating gene functions and developing next-generation therapeutics. Current techniques are challenged by the lack of cell-specific control designs or immunogenicity risk from foreign proteins. We develop a DNA repair inducible ribozyme switch that enables cell-specific control of gene expression in cells and in vivo. This strategy designs plasmids with a DNA lesion (8-oxoG and O 6 -MeG) site-specifically installed within the ribozyme encoding region, generating active hammerhead ribozyme for mRNA degradation due to transcriptional mutagenesis, whereas DNA repair yields a single-base mismatch in the ribozyme to abrogate its activity. This strategy is demonstrated to allow specific control of gene expression in cancer cells with overexpressed DNA repair enzymes such as MutY DNA glycosylase and O 6 -methylguanine-DNA-methyltransferases. It also shows the capability of conditionally regulating the expression of different proteins for signal reporting and gene editing, enabling DNA repair monitoring and targeted gene therapy in cancer cells. This strategy is demonstrated using the inducible CRISPR/Cas9 system for in vivo editing of oncogenic Polo-like kinase 1 in a mouse model, resulting in significant tumor growth suppression. The DNA repair inducible ribozyme switch may provide a compact system for cell-specific gene expression control toward precise gene therapy.}, archive = {J_ANGEW}, author = {Jieling Hong and Zhen Jiang and Zhenkun Wu and Jian-Hui Jiang}, doi = {10.1002/anie.202422042}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422042}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cell-specific control of mammalian gene expression using DNA repair inducible ribozyme switches}, volume = {64}, year = {2025}, }
• (2025). Spiro-fused vs 575-ringed boron-doped polycyclic π-systems: Selective synthesis, reactivity and properties. ANGEW, 64(12), e202422031. (www)

  @article{ , abstract = {Incorporation of heteroatoms and/or non-hexagonal rings into polycyclic aromatic hydrocarbons (PAHs) can alter their intrinsic structures and physical properties. However, it is challenging to construct PAHs featuring boron/carbon composition and non-hexagonal combination. Herein, we disclose the selective synthesis of spiro-type and pentagon/heptagon-containing boron-doped polycyclic π-systems by the Scholl reaction. Two spiro-fused organoboranes 1 and 2 and one 575-ringed boron-doped nanographene 3 were synthesized. The key point is that the boron-edged π-system enabled unexpected spiro-formation via dearomatization, whereas the boron-centered π-system enabled desired 575-ringed π-extension via cyclodehydrogenation. The thus-obtained molecules exhibit the intriguing but fully distinct reactivity, electronic structures and properties, for instance, while 2 may react with Brønsted acid to display reversible chemochromism and further convert into 1 , 3 possesses very broad absorption, short excited-state lifetime and no fluorescence nature. As disclosed, the boron atom together with the spirocycle region or 575-ringed structural motif significantly contribute to their characteristic properties. Thus, this study sheds light on control over the Scholl reaction using organoborane π-systems and will promote the exploration of more sophisticated polycyclic π-systems as organic reactive and optical scaffolds.}, archive = {J_ANGEW}, author = {Yujia Liu and Xinyu Tian and Zeyi Li and Tianyu Zhang and Liuzhong Yuan and Yue Wang and Chuandong Dou}, doi = {10.1002/anie.202422031}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spiro-fused vs 575-ringed boron-doped polycyclic π-systems: Selective synthesis, reactivity and properties}, volume = {64}, year = {2025}, }
• (2025). Conditional relay activation of theranostic prodrug by pretargeting bioorthogonal trigger and fluorescence-guided visible light irradiation. ANGEW, 64(12), e202422023. (www)

  @article{ , abstract = {Bioorthogonalized light-responsive click-and-uncage platform has enabled precise cell surface engineering and timed payload release, but most of such photoactivatable prodrugs have “always-on” photoactivity leading to the dark toxicity. On the other hand, the conditionally activatable photocage is limited to the application of fluorogenic probe/photosensitizer liberation. Herein, we devise a conditionally activatable theranostic platform based on the tetrazine (Tz)-boron-dipyrromethene (BODIPY) construct, in which tetrazine serves as a quencher motif to disable both the fluorescence and photoresponsivity of BODIPY. The uncaged BODIPY upon the bioorthogonal transformation of the tetrazine reinstates fluorescence on-target to guide the subsequent visible light irradiation thereby releasing the therapeutic payload in situ . The proof of concept for such “light where is lit up”-activated theranostics was demonstrated by the tetrazine-BODIPY conjugated SN-38 ( 1 ) with masked fluorescence, up to 70 times-reduced cytotoxicity, and good photostability. Upon an inverse electron-demand Diels–Alder (IEDDA) reaction between tetrazine unit on 1 and a biotinylated trans -cyclooctene (biotin-TCO) as a pretargeted trigger on tumor cell surface, the green fluorescence from BODIPY was fully restored for cell-selective imaging, which guided the green light irradiation (500–520 nm) to activate the caged drug SN-38 exerting potent cytotoxicity against tumor cells, offering high spatiotemporal precision of disease diagnosis and therapy.}, archive = {J_ANGEW}, author = {Shihong Li and Jing Pang and Yuanjun Sun and Yuchen Zhang and Ya-Qiu Long}, doi = {10.1002/anie.202422023}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422023}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conditional relay activation of theranostic prodrug by pretargeting bioorthogonal trigger and fluorescence-guided visible light irradiation}, volume = {64}, year = {2025}, }
• (2025). A dynamic metal-organic radical emission system. ANGEW, 64(12), e202422009. (www)

  @article{ , abstract = {Developing new organic radical emission systems and regulating their luminescence properties presents a significant challenge. Herein, we build dynamic and multi-emission band radical luminescence systems by co-assembling inorganic metal salts with carbonyl compounds in ionic liquids. After the assembling, dual-band, and excitation wavelength-dependent emission was observed upon ultraviolet light irradiation, one emission band originates from carbonyl radical after light irradiation, the other band from the ligand-metal charge transfer (LMCT) state, which benefits from the charge transfer from the radicals to the metal salts. The dual emission centers also introduce excitation wavelength-dependent properties for the molecules. In addition, three-band emission covering the visible and near-infrared regions can be shown when two or three kinds of metal ions are simultaneously doped into the radical system driven by the ligand-metal-metal charge transfer (LMMCT). Interestingly, visible light can quickly quench the radical emission of systems, thus realizing a dynamic luminescence. The LMMCT effect and strong supramolecular interactions significantly improve the photoluminescence quantum yield by up to 67.2 %. Moreover, such materials can be successfully used for detecting radioactive metal ions and information encryption. This study develops a platform for manufacturing various metal-organic radical emission systems with diverse properties.}, archive = {J_ANGEW}, author = {Xiang Li and Yuan Wang and Glib V. Baryshnikov and Ihor Sahalianov and Hans Ågren and Yuri Tanuma and Zhiyun Zhang and Cheng Qian and Muyu Cong and Tao Yi and Hongwei Wu}, doi = {10.1002/anie.202422009}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202422009}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A dynamic metal-organic radical emission system}, volume = {64}, year = {2025}, }
• (2025). Enhanced stability and properties of benzene-1,3,5-tricarboxamide supramolecular copolymers through engineered coupled equilibria**. ANGEW, 64(12), e202421991. (www)

  @article{ , abstract = {Improving the stability of multi-component and functional assemblies such as supramolecular copolymers without impeding their dynamicity is key for their implementation as innovative materials. Up to now, this has been achieved by a trial-and-error approach, requiring the time-consuming characterization of a series of supramolecular coassemblies. We report herein that this is possible to significantly enhance the stability of supramolecular copolymers by a minimal change in the chemical nature of one of the interacting monomers. This is achieved by replacing an ester function by an ether function in the structure of a chiral benzene-1,3,5-tricarboxamide (BTA) monomer, used as “sergeant”, coassembled with achiral monomers, the “soldiers”. Pseudo-phase diagrams, constructed by probing the nature of the coassemblies with multifarious analytical techniques, confirm that the greater stability of the resulting copolymers is mainly due to the minimization of competing species. This leads to better rheological and catalytic properties of the corresponding supramolecular copolymers. Favouring coassembly over undesired assembly pathways must be considered as a blueprint for the development of better-performing supramolecular multi-component systems.}, archive = {J_ANGEW}, author = {Huanjun Kong and Antonio Valverde-González and Régina Maruchenko and Laurent Bouteiller and Matthieu Raynal}, doi = {10.1002/anie.202421991}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421991}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced stability and properties of benzene-1,3,5-tricarboxamide supramolecular copolymers through engineered coupled equilibria**}, volume = {64}, year = {2025}, }
• (2025). Unveiling the structure-fluorogenic property relationship of seoul-fluor-derived bioorthogonal tetrazine probes. ANGEW, 64(12), e202421982. (www)

  @article{ , abstract = {Tetrazine (Tz)-embedded fluorescent probes, known for their fluorogenicity following bioorthogonal inverse electron-demand Diels–Alder (iEDDA) reactions, are extensively used in bioimaging. Despite extensive research on fluorogenic Tz probes, there has been limited systematic exploration of their fluorogenic responses with various dienophiles. In this study, we elucidate the structure-fluorogenic property relationship of bioorthogonal Tz probes. We synthesized a series of Seoul-Fluor-Tz (SF Tz ) probes designed to exhibit differentiated turn-on fluorescence upon iEDDA reactions with three dienophiles: trans- cyclooctene (TCO), bicyclo[6.1.0]nonyne (BCN), and spiro[2.3]hex-1-ene (Sph). Our findings revealed that the fluorogenic properties of the SF Tz probes are highly dependent on the structures of Tz-dienophile adducts. By systematically modifying the electronic properties and employing quantum chemical calculations, we developed a series of SF Tz probes with optimal dienophile-dependent fluorescence. These probes enabled simultaneous dual-color imaging of different cellular targets using a single probe, providing a robust approach for advanced bioimaging applications that require precise and efficient multicolor labeling strategies.}, archive = {J_ANGEW}, author = {Hayoung Son and Dahham Kim and Sohee Kim and Wan Gi Byun and Seung Bum Park}, doi = {10.1002/anie.202421982}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421982}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the structure-fluorogenic property relationship of seoul-fluor-derived bioorthogonal tetrazine probes}, volume = {64}, year = {2025}, }
• (2025). Near-infrared chemiluminophore switches photodynamic processes via protein complexation for biomarker-activatable cancer therapy. ANGEW, 64(12), e202421962. (www)

  @article{ , abstract = {Despite the potential in cancer therapy, phototheranostic agents often face two challenges: limited diagnostic sensitivity due to tissue autofluorescence and suboptimal therapeutic efficacy due to the Type-II photodynamic process with the heavy oxygen reliance. In contrast, chemiluminescent theranostic agents without the requirement of real-time light excitation can address the issue of tissue autofluorescence, which however have been rarely reported for photodynamic therapy (PDT), not to mention less oxygen-dependent Type-I PDT. In this work, we synthesize near-infrared (NIR) chemiluminophores with the specific binding towards human serum albumin (HSA) to form chemiluminophore-protein complex for cancer detection and photodynamic therapy. Interestingly, after the complexation with HSA, the chemiluminescence (CL) intensities of chemiluminophores are enhanced by over 10-fold; meanwhile, the photodynamic process switches from Type-II (singlet-oxygen-generation dominated) to Type-I (superoxide anion and hydroxyl radical dominated), while the previously reported activated chemiluminophore with non-specific HSA binding can't switch photodynamic process. Based on the optimal chemiluminophore, a nitroreductase-activatable CL probe-protein complex is synthesized, which specially turns on its CL and Type-I PDT in hypoxic tumors for precision therapy. Thus, this study provides a complexation strategy to improve phototheranostic performance of chemiluminophores.}, archive = {J_ANGEW}, author = {Jingsheng Huang and Jing Liu and Jiayan Wu and Mengke Xu and Youshi Lin and Kanyi Pu}, doi = {10.1002/anie.202421962}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421962}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared chemiluminophore switches photodynamic processes via protein complexation for biomarker-activatable cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Isomerization-controlled aggregation in photoactive layer: An additive strategy for organic solar cells with over 19.5 % efficiency. ANGEW, 64(12), e202421953. (www)

  @article{ , abstract = {Morphology control of the photoactive layer is crucial for achieving high-performance organic solar cells (OSCs), yet it remains a significant challenge in this field. One effective approach is the additive strategy, which fine-tunes the morphology of the photoactive layer. However, the underlying mechanisms governing the impact of different types of additives from liquid, solid, to volatile solid, on the bulk heterojunction morphology and device performance are not fully understood. Herein, we present an aggregation regulation strategy for acceptor molecules by incorporating three novel isomeric additives: 4-bromo-1,2-dichlorobenzene (LCB), 1-bromo-2,4-dichlorobenzene (SCB), and 2-bromo-1,4-dichlorobenzene (VCB) into the blend active layer. This approach optimizes the bulk heterojunction morphology and enhances the photovoltaic performance of OSCs. Our results reveal that these additives induce stepwise regulation of acceptor molecule aggregation during film formation. The liquid additive LCB primarily extends solvent evaporation time, effectively preventing excessive aggregation, while the solid additive SCB significantly shortens the aggregation period during the film evolution, resulting in the most compact molecular π–π stacking. Furthermore, the volatile solid additive VCB fine-tunes the intermolecular interactions and crystallization within the active layer, promoting optimal molecular self-assembly and aggregation for ideal molecular stacking. Consequently, the power conversion efficiencies of 19.33 % and 19.51 % were achieved for the VCB-processed D18 : L8-BO- and PM6 : L8-BO-based OSCs, respectively, outperforming the LCB-processed and SCB-processed devices.}, archive = {J_ANGEW}, author = {Zihao Xia and Chuanlin Gao and Zhixiang Xie and Miaoxuan Wu and Hansheng Chen and Tongzi Li and Jiang Zhou and Ting Cai and Huawei Hu and Jing Shuai and Chen Xie and Guangye Zhang and Wenduo Chen and Shenghua Liu}, doi = {10.1002/anie.202421953}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421953}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isomerization-controlled aggregation in photoactive layer: An additive strategy for organic solar cells with over 19.5 % efficiency}, volume = {64}, year = {2025}, }
• (2025). A small-molecule approach enables RNA aptamers to function as sensors for reactive inorganic targets. ANGEW, 64(12), e202421936. (www)

  @article{ , abstract = {Fluorescent light-up aptamer (FLAP) systems are promising (bio)sensing platforms that are genetically encodable. However, FLAP-mediated detection of each distinct target necessitates either in vitro selection or engineering of nucleic acid sequences. Furthermore, an aptamer that binds an inorganic target or a chemical species with a short lifetime is challenging to realize. Here, we describe a small-molecule approach that makes it possible for a single FLAP system to detect chemically unique, non-fluorogenic, and reactive inorganics. We developed functionalized pre-ligands of RNA aptamers that bind benzylidene imidazolinones (Baby Spinach, Broccolli, Squash). Reactive inorganics, hydrogen sulfide (H 2 S/HS − ) and hydrogen peroxide (H 2 O 2 ), can specifically convert these pre-ligands into native ligands that fluoresce with FLAPs. Adaptation of this platform to live cells opened an opportunity for constructing whole-cell sensors: Escherichia coli transformed with a Baby Spinach-encoding plasmid and incubated with pre-ligands generated fluorescence in response to exogenous H 2 S/HS − or H 2 O 2 . Leveraging the functional group reactivity of small molecules eliminates the requirement of in vitro selection of a new aptamer sequence or oligonucleotide scaffold engineering for distinct molecular targets. Our method allows for detecting inorganic, short-lived species, thereby advancing FLAP systems beyond their current capabilities.}, archive = {J_ANGEW}, author = {Tushar Aggarwal and Liming Wang and Bryan Gutierrez and Hakan Guven and Huseyin Erguven and Sarah Cho and Enver Cagri Izgu}, doi = {10.1002/anie.202421936}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421936}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A small-molecule approach enables RNA aptamers to function as sensors for reactive inorganic targets}, volume = {64}, year = {2025}, }
• (2025). A generally applicable method for disentangling the effect of individual noncovalent interactions on the binding energy. ANGEW, 64(12), e202421922. (www)

  @article{ , abstract = {We introduce the fragment-pairwise Local Energy Decomposition (fp-LED) scheme for precise quantification of individual interactions contributing to the binding energy of arbitrary chemical entities, such as protein-ligand binding energies, lattice energies of molecular crystals, or association energies of large biomolecular assemblies. Using fp-LED, we can assess whether the contribution to the binding energy arising from noncovalent interactions between pairs of molecular fragments in any chemical system is attractive or repulsive, and accurately quantify its magnitude at the coupled cluster level - commonly considered as the “gold standard” of computational chemistry. Such insights are crucial for advancing molecular and material design strategies in fields like catalysis and therapeutic development. Illustrative applications across diverse fields demonstrate the versatility and accuracy of this theoretical framework, promising profound implications for fundamental understanding and practical applications.}, archive = {J_ANGEW}, author = {Ahmet Altun and Isaac F. Leach and Frank Neese and Giovanni Bistoni}, doi = {10.1002/anie.202421922}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421922}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A generally applicable method for disentangling the effect of individual noncovalent interactions on the binding energy}, volume = {64}, year = {2025}, }
• (2025). Mn doping at high-activity octahedral vacancies of γ-Fe2O3 for oxygen reduction reaction electrocatalysis in metal-air batteries. ANGEW, 64(12), e202421918. (www)

  @article{ , abstract = {γ-Fe 2 O 3 with the intrinsic cation vacancies is an ideal substrate for heteroatom doping into the highly active octahedral sites in spinel oxide catalysts. However, it is still a challenge to confirm the vacancy location of γ-Fe 2 O 3 through experiments and obtain enhanced catalytic performance by preferential occupation of octahedral sites for heteroatom doping. Here, a Mn-doped γ-Fe 2 O 3 incorporated with carbon nanotubes catalyst was developed to successfully achieve preferential doping into highly active octahedral sites by employing γ-Fe 2 O 3 as the precursor. Further, the vacancy in γ-Fe 2 O 3 was only located on octahedral sites rather than tetrahedral ones, which was first proved by direct experimental evidence through the clarification doping sites of Mn. Notably, the catalyst shows outstanding activity towards oxygen reduction reaction with the half-wave potential of 0.82 V and 0.64 V vs. reversible hydrogen electrode in alkaline and neutral electrolytes, respectively, as well as the maximum power density of 179 mWcm −2 and 403 mWcm −2 for Mg-air batteries and Al-air batteries, respectively. It could be attributed to the synergistic effect of the doping Mn on octahedral sites and the substrate γ-Fe 2 O 3 along with the modification of the adsorption/desorption properties for oxygen-containing intermediates as well as the optimization of the reaction energy barriers.}, archive = {J_ANGEW}, author = {Liuzhe Qiu and Zhong Wu and Yingjie Liu and Zhenbo Qin and Yichun Liu and Jinfeng Zhang and Yida Deng and Wenbin Hu}, doi = {10.1002/anie.202421918}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421918}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mn doping at high-activity octahedral vacancies of γ-Fe2O3 for oxygen reduction reaction electrocatalysis in metal-air batteries}, volume = {64}, year = {2025}, }
• (2025). Reconfigurable CMOS-compatible supercapacitor-diode empowering computation efficiency for human-machine interaction. ANGEW, 64(12), e202421913. (www)

  @article{ , abstract = {Biological system utilizes unidirectional ion flow to produce and transmit signals. To realize bioinspired artificial intelligence and thus seamless human-machine interaction, ion rectification devices should be developed. Here, a reconfigurable CMOS-compatible supercapacitor-diode (CAPode) is developed by resettling the pseudo-capacitive and electrochemical-double-layer-capacitive components of a lithium-ion pseudocapacitor into the positive and negative voltage regions respectively through engineering the redox peaks. This CAPode exhibits good ion rectification and charge-storage bifunction with high rectification ratio (RR) (RR I ~20, RR II ~0.83), large areal capacitance (17 mF cm −2 ) and long cycling stability (5000 cycles). More importantly, two main computing paradigms in the biological system are efficiently realized based on this CAPode by empowering the supercapacitor function into the diode: (I) multivalued ionic logic gates are constructed based on the tunable ion rectification characteristics induced by the bifunction of this CAPode for mimicking the dendritic computing; (II) all-CAPode based reservoir computing is implemented based on the reconfigurable volatile and nonvolatile charge-storage characteristics of this CAPode for mimicking the neuromorphic computing. This work paves a new way towards seamless and high-efficiency human-machine interaction.}, archive = {J_ANGEW}, author = {Dong Wang and Bofan Yang and Ziye Zhou and Zhihan Zhang and Zhengxiao Wu and Xiaodong Huang}, doi = {10.1002/anie.202421913}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reconfigurable CMOS-compatible supercapacitor-diode empowering computation efficiency for human-machine interaction}, volume = {64}, year = {2025}, }
• (2025). Artificial gold enzymes using a genetically encoded thiophenol-based noble-metal-binding ligand. ANGEW, 64(12), e202421912. (www)

  @article{ , abstract = {Incorporating noble metals in artificial metalloenzymes (ArMs) is challenging due to the lack of suitable soft coordinating ligands among natural amino acids. We present a new class of ArMs featuring a genetically encoded noble-metal-binding site based on a non-canonical thiophenol-based amino acid, 4-mercaptophenylalanine ( p SHF), incorporated in the transcriptional regulator LmrR through stop codon suppression. We demonstrate that p SHF is an excellent ligand for noble metals in their low oxidation states. The corresponding gold(I) enzyme was characterised by mass spectrometry, UV/Vis spectroscopy and X-ray crystallography and successfully catalysed hydroamination reactions of 2-ethynyl anilines with turnover numbers over 50. Interestingly, two equivalents of gold(I) per protein dimer proved to be required for activity. Up to 98 % regioselectivity in the hydroamination of an ethynylphenylurea substrate was observed, yielding the corresponding phenyl-dihydroquinazolinone product, consistent with a π-activation mechanism by single gold centres. The ArM was optimized by site saturation mutagenesis using an on-bead screening protocol. This resulted in a single mutant that showed higher activity for one class of substrates. This work brings the power of noble-metal catalysis into the realm of enzyme engineering and establishes thiophenols as alternative ligands for noble metals, providing new opportunities in coordination chemistry and catalysis.}, archive = {J_ANGEW}, author = {Mathijs J. Veen and Friso S. Aalbers and Henriëtte J. Rozeboom and Andy-Mark W. H. Thunnissen and Daniel F. Sauer and Gerard Roelfes}, doi = {10.1002/anie.202421912}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421912}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial gold enzymes using a genetically encoded thiophenol-based noble-metal-binding ligand}, volume = {64}, year = {2025}, }
• (2025). Thermally induced reversible martensitic phase transition and self-healing in nickel glycinamide crystals. ANGEW, 64(12), e202421769. (www)

  @article{ , abstract = {Martensitic phase transitions and self-healing in molecular compounds are extremely rare, and while they carry potential for rapid energy transduction, they are currently found only by serendipity. Here, we report the observation of both phenomena in a coordination compound of glycinamide (Glyam), [Ni(H 2 O) 2 (Glyam) 2 ]I 2 ( 1 ). Upon cooling to 205–213 K, the high-temperature polymorph of this material ( 1 RT ) transforms into twinned crystals of the low-temperature polymorph ( 1 LT(twinned) ), while upon heating, it is converted back to 1 RT in the temperature range 217–223 K. When this transformation occurs in single crystals, evolution of cracks is observed upon cooling that disappear upon heating. The forward transition 1 RT → 1 LT(twinned) is completed in a few seconds, while the reverse one, 1 LT(twinned) → 1 RT , proceeds up to several hours, contrary to the fast transition in polycrystalline samples. We determined the concomitant presence of 1 RT and 1 LT(twinned ) in the same single crystal. The crystal structure analysis revealed complex inter- and intramolecular displacements of atoms during the transition. To the best of our knowledge, this is only the second report where a thermally induced reversible martensitic phase transition and self-healing are observed in crystals of a coordination compound, and indicates the potential generality of these extraordinary phenomena.}, archive = {J_ANGEW}, author = {Darko Vušak and Panče Naumov and Želimir Jelčić and Dubravka Matković-Čalogović and Biserka Prugovečki}, doi = {10.1002/anie.202421769}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421769}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermally induced reversible martensitic phase transition and self-healing in nickel glycinamide crystals}, volume = {64}, year = {2025}, }
• (2025). Optimized adsorption of had and OHad over amorphous SrRuPtOxHy nanobelts towards efficient alkaline fuel cell catalysis. ANGEW, 64(12), e202421013. (www)

  @article{ , abstract = {PtRu-based catalysts toward hydrogen oxidation reaction (HOR) suffer from low efficiency, CO poisoning and over-oxidation at high potentials. In this work, an amorphization strategy is adopted for preparation of amorphous SrRuPtO x H y nanobelts (a-SrRuPtO x H y NBs). The a-SrRuPtO x H y NBs has optimized adsorption of intermediates (H and OH), increased number of active sites, highly weakened CO poisoning and enhanced anti-oxidation ability owing to the special amorphous structure. Consequently, a-SrRuPtO x H y NBs displays superior HOR performance with a mass activity of 7.5 A/mg Pt+Ru , 25 and 5 times of that of SrRuPt(OH) x NBs and commercial PtRu/C, respectively, and long-lasting stability. Besides, a peak power density of 750 mW/cm 2 and a specific power of 14.8 W/mg Pt+Ru have been achieved for a-SrRuPtO x H y NBs at a low loading of 0.05 mg Pt+Ru /cm 2 , surpassing many reported HOR catalysts. Mechanism investigation indicates that Pt and Ru are present in oxide/hydroxide forms and H in a-SrRuPtO x H y NBs participates in HOR. Ab initio molecular dynamics (AIMD) simulations and density functional theory (DFT) calculations show that there are three catalytic mechanisms participating in a-SrRuPtO x H y NBs, which all exhibit low catalytic barrier and highly improved HOR efficiency. This work provides a new strategy for designing high-performance catalysts towards fuel cells.}, archive = {J_ANGEW}, author = {Siyu Liu and Shangheng Liu and Jingliang Bao and Zhongliang Huang and Licheng Wei and Nanjun Chen and Zhiwei Hu and Wei-Hsiang Huang and Chih-Wen Pao and Qingyu Kong and Jiajia Han and Leigang Li and Xiaoqing Huang}, doi = {10.1002/anie.202421013}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202421013}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimized adsorption of had and OHad over amorphous SrRuPtOxHy nanobelts towards efficient alkaline fuel cell catalysis}, volume = {64}, year = {2025}, }
• (2025). Diastereoselective polypseudorotaxane formation with planar chiral pillar[5]arenes via co-crystallization processes. ANGEW, 64(12), e202420115. (www)

  @article{ , abstract = {As the number of chiral ring molecules in chiral polyrotaxane increases, the number of possible stereoisomers exponentially increases. Consequently, the selective synthesis of a specific stereoisomer becomes much more challenging. To address this problem, we co-crystallized poly(ethylene glycol) and a diastereomeric ring molecule, pillar[5]arene, in the solid state. The co-crystallization formed polypseudorotaxanes with a high diastereomeric excess (ca. 88 % de ), meaning that polypseudorotaxanes containing ( S , pS ) stereoisomer pillar[5]arene rings were synthesized selectively. By contrast, in solution and evaporation systems, the selectivity remained low (ca. 10 % de ). The results suggested that the packing effect by the co-crystallization contributed to the denser assembly of ring molecules on the polymeric chain, resulting in the diastereoselective formation. High diastereoselectivity was also observed even in higher-molecular-weight poly(ethylene glycol)s. These selectivities arose from the cooperative effects of the ring molecules on the polymeric chain, which were supported by calculating the stabilization energy.}, archive = {J_ANGEW}, author = {Kiichi Yasuzawa and Keisuke Wada and Shixin Fa and Yuuya Nagata and Kenichi Kato and Shunsuke Ohtani and Motohiro Mizuno and Tomoki Ogoshi}, doi = {10.1002/anie.202420115}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202420115}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diastereoselective polypseudorotaxane formation with planar chiral pillar[5]arenes via co-crystallization processes}, volume = {64}, year = {2025}, }
• (2025). Chemistry as a catalyst for transforming the health and wealth of south africa. ANGEW, 64(12), e202419681. (www)

  @article{ , abstract = {South Africa's rich natural resources remain a key driver of its chemical industrialisation but are tainted and constrained by its complex colonial history. Thirty years since the advent of democracy in South Africa, deep sociopolitical inequalities are amplified by an intolerable infectious disease burden amongst disadvantaged communities. In that respect, South Africa shares challenges with many other nations in the Global South; there are limited opportunities for the economic development and growth needed to uplift all strata of society. This Viewpoint examines the role of the chemical sciences in South Africa's unique history and the current state of its academic and industrial sectors, with a focus on the intersection of chemistry, healthcare and biomedical research. We argue that the opportunities offered through chemistry research and development, including local manufacturing, should be exploited and that scientific advancements should be tailored to and integrated with the socioeconomic realities of South Africa for an effective and multidisciplinary approach to improving healthcare outcomes. This Viewpoint aims to inspire a renewed focus on the pivotal role of chemical scientists and their broader societal contributions to combating the country's infectious disease burden and shaping a healthier future for South Africa.}, archive = {J_ANGEW}, author = {Clinton G. L. Veale and John G. Woodland and Kathryn J. Wicht and Kelly Chibale}, doi = {10.1002/anie.202419681}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202419681}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemistry as a catalyst for transforming the health and wealth of south africa}, volume = {64}, year = {2025}, }
• (2025). Mechanics-photophysics correlation in tough, stretchable and long-lived room temperature phosphorescence ionogels deciphered by dynamic mechanical analysis. ANGEW, 64(12), e202419114. (www)

  @article{ , abstract = {The development of tough, stretchable and long-lived room temperature phosphorescence (RTP) materials holds great significance for manufacturing and processing photoluminescent materials, but limited techniques are available to profile their mechanics-photophysics correlation. Here we report glassy ionogels, and their mechanical properties and photophysical properties are fused by dynamic mechanical analysis (DMA), functioning like a human brain that perceives a material instantaneously by linking sensory perception and cognition. Depending on two special temperatures presented in DMA curves, T loss (the peak of loss modulus ( E” )) and T g (glass transition temperature), the ionogels can vary from being either tough with persistent phosphorescence, extensible with effective phosphorescence or resilience with inefficient phosphorescence. Leveraging this method, we achieve stretchable and long-lived RTP ionogels with tensile yield strength of 53 MPa, tensile strain of 497 %, Young's modulus of 782 MPa, toughness of 111.2 MJ/m 3 , and lifetime of 113.05 ms. Our work provides a simple yet powerful method to reveal the mechanics-photophysics correlation of RTP ionogels, to predict their performance without laborious synthesis and characterization, opening new avenues for applications of RTP materials, including applications in harsh conditions (257 K or 347 K), shape memory and shape reconstruction.}, archive = {J_ANGEW}, author = {Xipeng Yang and Ningyan Li and Binbin Wang and Panyi Chen and Song Ma and Yifan Deng and Shaoyu Lü and Yu Tang}, doi = {10.1002/anie.202419114}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202419114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanics-photophysics correlation in tough, stretchable and long-lived room temperature phosphorescence ionogels deciphered by dynamic mechanical analysis}, volume = {64}, year = {2025}, }
• (2025). Ultrasensitive characterization of native bacterial biofilms via dynamic nuclear polarization-enhanced solid-state NMR. ANGEW, 64(12), e202418146. (www)

  @article{ , abstract = {Bacterial biofilms are major contributors to persistent infections and antimicrobial resistance, posing significant challenges to treatment. However, obtaining high-resolution structural information on native bacterial biofilms has remained elusive due to the methodological limitations associated with analyzing complex biological samples. Solid-state NMR (ssNMR) has shown promise in this regard, but its conventional application is hindered by sensitivity constraints for unlabeled samples. In this study, we utilized high-sensitivity Dynamic Nuclear Polarization (DNP) ssNMR to characterize native Pseudomonas fluorescens colony biofilms. The ~75-fold sensitivity enhancement provided by DNP enabled structural characterization without isotope labeling or chemical/physical modification. We successfully collected 1D 13 C/ 15 N, and 2D 1 H− 13 C, 1 H− 15 N and 13 C− 13 C ssNMR spectra within seconds, minutes or hours, facilitating the identification and quantification of biofilm extracellular matrix (ECM) components. Additionally, DNP ssNMR allowed quantitative detection of both flexible and rigid biofilm components by favorable freezing conditions. This study represents the first application of ultrasensitive DNP ssNMR to characterize a native bacterial biofilm, significantly expanding the capabilities of ssNMR for analyzing the composition and structure of a wide array of in vitro and ex vivo biofilms. The versatility of this approach will accelerate structure-guided efforts to combat infections caused by biofilm-forming microbes.}, archive = {J_ANGEW}, author = {Chang-Hyeock Byeon and Ted Kinney and Hakan Saricayir and Kasper Holst Hansen and Faith J. Scott and Sadhana Srinivasa and Meghan K. Wells and Frederic Mentink-Vigier and Wook Kim and Ümit Akbey}, doi = {10.1002/anie.202418146}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202418146}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrasensitive characterization of native bacterial biofilms via dynamic nuclear polarization-enhanced solid-state NMR}, volume = {64}, year = {2025}, }
• (2025). Simultaneous fabrication of p and m helices in one-component chiral system by methanol-water mediated dual assembly pathway. ANGEW, 64(12), e202417876. (www)

  @article{ , abstract = {The synergetic evolution of multiple chiral structures stemmed from same building units is ubiquitous in nature and vital to living systems, but achieving it in artificial systems remains a challenge. Herein, we report a methanol-water mediated dual assembly pathway strategy for simultaneous construction of P and M helices in one-component chiral system. The conformation of l -phenylaniline derivates (LBpyF) is controlled to folded state in CH 3 OH due to the hydrogen bonds as well as C−H⋅⋅⋅π interaction between LBpyF and CH 3 OH. Addition of H 2 O into above CH 3 OH solution of LBpyF results in the simultaneous occurrence of two self-assembly pathways and double networks of P and M helices were therefore formed, due to the synchronous process of 1) self-assembly of folded LBpyF into M-helices and 2) H 2 O induced unfolding of folded LBpyF molecules followed by self-assembly of them into P-helices. The bipyridine core, phenyl ring, amide unit all adapted into different stacking modes in M-helices and P-helices, and energy analysis indicated that the minority M-helices were more thermodynamically favored products. This study provides an approach to explore synergetic evolution of multiple chiral structures by manipulating the multiple assembly pathway.}, archive = {J_ANGEW}, author = {Laiben Gao and Kaikai Yang and Chao Xing and Biyan Lin and Changli Zhao and Xiaoqiu Dou and Chuanliang Feng}, doi = {10.1002/anie.202417876}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202417876}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous fabrication of p and m helices in one-component chiral system by methanol-water mediated dual assembly pathway}, volume = {64}, year = {2025}, }
• (2025). Printing cell embedded sacrificial strategy for microvasculature using degradable DNA biolubricant. ANGEW, 64(12), e202417510. (www)

  @article{ , abstract = {Microvasculature is essential for the continued function of cells in tissue and is fundamental in the fields of tissue engineering, organ repair and drug screening. However, the fabrication of microvasculature is still challenging using existing strategies. Here, we developed a general PRINting Cell Embedded Sacrificial Strategy (PRINCESS) and successfully fabricated microvasculatures using degradable DNA biolubricant. This is the first demonstration of direct cell printing to fabricate microvasculature, which eliminates the need for a subsequent cell seeding process and the associated deficiencies. Utilizing the shear-thinning property of DNA hydrogels as a novel sacrificial, cell-laden biolubricant, we can print a 70 μm endothelialized microvasculature, breaking the limit of 100 μm. To our best knowledge, this is the smallest endothelialized microvasculature that has ever been bioprinted so far. In addition, the self-healing property of DNA hydrogels allows the creation of continuous branched structures. This strategy provides a new platform for constructing complex hierarchical vascular networks and offers new opportunity towards engineering thick tissues. The extremely low volume of sacrificial biolubricant paves the way for DNA hydrogels to be used in practical tissue engineering applications. The high-resolution bioprinting technique also exhibits great potential for printing lymphatics, retinas and neural networks in the future.}, archive = {J_ANGEW}, author = {Jiezhong Shi and Yifei Wan and Haoyang Jia and Gregor Skeldon and Dirk Jan Cornelissen and Katrina Wesencraft and Junxi Wu and Gail McConnell and Quan Chen and Dongsheng Liu and Wenmiao Shu}, doi = {10.1002/anie.202417510}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202417510}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Printing cell embedded sacrificial strategy for microvasculature using degradable DNA biolubricant}, volume = {64}, year = {2025}, }
• (2025). Alcohol self-aggregation: The preferred configurations of the ethanol trimer. ANGEW, 64(12), e202415229. (www)

  @article{ , abstract = {An atomic-level knowledge of the aggregation of archetypal molecular systems is essential to accurately model supramolecular structures and the transition from gas to liquid phase. The structures and forces involved in ethanol aggregation have been investigated using microwave spectroscopy and extensive quantum chemical calculations. Four isomers of the ethanol trimer have been observed and identified based on comparisons between experimental and predicted spectroscopic parameters, and considering collisional relaxation in the supersonic expansion. All observed isomers exhibit O−H O hydrogen bonds between the hydroxyl groups forming a six-membered ring. Additionally, secondary C−H O hydrogen bonds and H H dispersion contacts participate in the stabilization of the complexes with remarkably similar energy contributions. Structures where there is a mixture of gauche and trans conformations of ethanol are favored, with gauche conformations being predominant and no evidence of homochirality synchronization. Our results underscore the critical changes involved in aggregation as the size of the system increases and shed light on the unique properties and behavior of ethanol in chemical and biological systems.}, archive = {J_ANGEW}, author = {S. Indira Murugachandran and Isabel Peña and Al Mokhtar Lamsabhi and Manuel Yáñez and M. Eugenia Sanz}, doi = {10.1002/anie.202415229}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {12}, pages = {e202415229}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alcohol self-aggregation: The preferred configurations of the ethanol trimer}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Contrasting mechanochromic luminescence of enantiopure and racemic pyrenylprolinamides: Elucidating solid-state excimer orientation by circularly polarized luminescence. ANGEW, 64(11), e202581162. (www)

  @article{ , archive = {J_ANGEW}, author = {Suguru Ito and Shin Wakiyama and Hao Chen and Masato Abekura and Hidehiro Uekusa and Ryoya Ikemura and Yoshitane Imai}, doi = {10.1002/anie.202581162}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202581162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Contrasting mechanochromic luminescence of enantiopure and racemic pyrenylprolinamides: Elucidating solid-state excimer orientation by circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Orthogonal-group-controlled site-selective I-branching of poly-N-acetyllactosamine chains reveals unique binding specificities of proteins towards I-antigens. ANGEW, 64(11), e202581161. (www)

  @article{ , archive = {J_ANGEW}, author = {Shumin Bao and Tangliang Shen and Congcong Chen and Jinghua Han and Virginia Tajadura-Ortega and MohammadHossein Shabahang and Zhenming Du and Ten Feizi and Wengang Chai and Lei Li}, doi = {10.1002/anie.202581161}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202581161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Orthogonal-group-controlled site-selective I-branching of poly-N-acetyllactosamine chains reveals unique binding specificities of proteins towards I-antigens}, volume = {64}, year = {2025}, }
• (2025). Inside cover: In/Outside catalytic sites of the pore walls in one-dimensional covalent organic frameworks for oxygen reduction reaction (Angew. chem. int. ed. 11/2025). ANGEW, 64(11), e202502955. (www)

  @article{ , archive = {J_ANGEW}, author = {Shuai Yang and Zejin He and Xuewen Li and Bingbao Mei and Yifan Huang and Qing Xu and Zheng Jiang}, doi = {10.1002/anie.202502955}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202502955}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: In/Outside catalytic sites of the pore walls in one-dimensional covalent organic frameworks for oxygen reduction reaction (Angew. chem. int. ed. 11/2025)}, volume = {64}, year = {2025}, }
• (2025). Back cover: Monodisperse chemical oligophosphorylation of peptides via protected oligophosphorimidazolide reagents (Angew. chem. int. ed. 11/2025). ANGEW, 64(11), e202502765. (www)

  @article{ , archive = {J_ANGEW}, author = {Kevin Qian and Björn Hanf and Christopher Cummins and Dorothea Fiedler}, doi = {10.1002/anie.202502765}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202502765}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Monodisperse chemical oligophosphorylation of peptides via protected oligophosphorimidazolide reagents (Angew. chem. int. ed. 11/2025)}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: Correction to “Tandem methanolysis and catalytic transfer hydrogenolysis of polyethylene terephthalate to p-xylene over Cu/ZnZrOx catalysts”. ANGEW, 64(11), e202502639. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202502639}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202502639}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: Correction to “Tandem methanolysis and catalytic transfer hydrogenolysis of polyethylene terephthalate to p-xylene over Cu/ZnZrOx catalysts”}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Regioregular poly(p-phenylene iminoborane): A strictly alternating BN-isostere of poly(p-phenylene vinylene) with stimuli-responsive behavior (Angew. chem. int. ed. 11/2025). ANGEW, 64(11), e202502494. (www)

  @article{ , archive = {J_ANGEW}, author = {Johannes Chorbacher and Jonas Klopf and Alexandra Friedrich and Maximilian Fest and Johannes S. Schneider and Bernd Engels and Holger Helten}, doi = {10.1002/anie.202502494}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202502494}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Regioregular poly(p-phenylene iminoborane): A strictly alternating BN-isostere of poly(p-phenylene vinylene) with stimuli-responsive behavior (Angew. chem. int. ed. 11/2025)}, volume = {64}, year = {2025}, }
• (2025). Anna vagstad. ANGEW, 64(11), e202502417. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202502417}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202502417}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anna vagstad}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Co-feeding CO2 for methylfuran aromatization over bifunctional zeolite-supported ZnMoO4 (Angew. chem. int. ed. 11/2025). ANGEW, 64(11), e202502407. (www)

  @article{ , archive = {J_ANGEW}, author = {Shengpeng Xia and Kun Zhao and Yunfei Gao and Yuyang Fan and Chenyang Wang and Tongpo Yu and Hong Wang and Jinyang Zhang and Zhandong Wang and Xing Zhu and Zengli Zhao and Anqing Zheng}, doi = {10.1002/anie.202502407}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202502407}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Co-feeding CO2 for methylfuran aromatization over bifunctional zeolite-supported ZnMoO4 (Angew. chem. int. ed. 11/2025)}, volume = {64}, year = {2025}, }
• (2025). Semirational protein engineering of a decarboxylative aldolase for the regiodivergent and stereodivergent synthesis of cyclic imino acids. ANGEW, 64(11), e202500080. (www)

  @article{ , abstract = {Aldolases are powerful C−C bond-forming enzymes for asymmetric organic synthesis because of their supreme stereoselectivity, compatibility with diverse electrophiles and nucleophiles, and promising scalability. Stereodivergent engineering of aldolases to tune the selectivity for the synthesis of stereoisomers of chiral molecules is highly desirable but has rarely been reported. Herein we report the semirational engineering of the decarboxylative aldolase UstD with a focused rational iterative site-specific mutagenesis (FRISM) strategy to perform a C−C bond-forming reaction with dione electrophiles. The variant obtained from a small mutant library showed divergent regioselectivity and diastereoselectivity compared to the wild-type enzyme, resulting in the production of 30 cyclic imino acids with stereocenters at the α and γ positions. Molecular dynamics simulation and kinetic data revealed the basis of selectivity.}, archive = {J_ANGEW}, author = {Yuqiu Lan and Chenghua Zhang and Chunping Tang and Yang Ye and Rui Zhang and Xiang Sheng and Cangsong Liao}, doi = {10.1002/anie.202500080}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202500080}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Semirational protein engineering of a decarboxylative aldolase for the regiodivergent and stereodivergent synthesis of cyclic imino acids}, volume = {64}, year = {2025}, }
• (2025). Enhanced azo dye removal through sequential ultrasound-assisted-treatment and photocatalysis using CdZnS. ANGEW, 64(11), e202425508. (www)

  @article{ , abstract = {The treatment of high-concentration azo dyes remains challenging due to the inherent limitations of conventional single-mode approaches. Here, we propose an integrated strategy that sequentially combines ultrasound-assisted adsorption with photocatalysis using CdZnS solid solutions to efficiently and rapidly remove high-concentration azo dyes. CdZnS exhibits high adsorption capacity and exceptional photocatalytic activity, enabling initial dye capture and enrichment, followed by significantly enhanced photocatalytic degradation. The adsorption of Congo Red (CR) on CdZnS solid solutions follows the Freundlich and pseudo-second-order models, demonstrating a multilayer adsorption behavior involving physical and chemical interactions. Ultrasound assistance during the first stage not only significantly reduces equilibrium time, but also results in enhanced negative charges in CdZnS that extend to the subsequent photocatalysis stage. This charge enhancement substantially improves CR photodegradation performance, establishing synergistic interactions between ultrasonic treatment and photodegradation. The system demonstrates excellent performance in treating both concentrated single dyes and complex dye mixtures, maintaining high efficiency over multiple treatment cycles. This integrated approach provides new insights for developing more effective technologies for dye degradation and practical wastewater treatment applications.}, archive = {J_ANGEW}, author = {Wenchao Li and Chi Cheng and Jiaqi Zhao and Yongxiu Song and Chuang Xue}, doi = {10.1002/anie.202425508}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202425508}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced azo dye removal through sequential ultrasound-assisted-treatment and photocatalysis using CdZnS}, volume = {64}, year = {2025}, }
• (2025). Manipulating the dynamics of chiral molecular bearings through subtle structural changes of guest molecules. ANGEW, 64(11), e202425308. (www)

  @article{ , abstract = {By introducing fluorine substituents, anisotropic rotational motion was induced in diamondoid guests trapped in cylindrical hosts arranged in a 2D honeycomb crystal. Despite the subtle structural changes, the substituent hindered flipping motions in the host and biased its rotations toward tilted precession. The fluorine substituent facilitated the dielectric response of the crystal, as revealed through dielectric constant measurements, which provided insight into the detailed dynamics of the anisotropic rotations. The up-down flipping motion of the guest within the 2D crystal was constrained by an energy barrier but remained manipulable under an external electric field. Consequently, the angular momentum of the spinning guest, with its C−F pole, was forced to align with the applied electric field.}, archive = {J_ANGEW}, author = {Yuki Kotani and Ryosuke Katsuno and Kohei Sambe and Seiya Terasaki and Taisuke Matsuno and Koki Ikemoto and Tomoyuki Akutagawa and Hiroyuki Isobe}, doi = {10.1002/anie.202425308}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202425308}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating the dynamics of chiral molecular bearings through subtle structural changes of guest molecules}, volume = {64}, year = {2025}, }
• (2025). Helical quintulene: Synthesis, chirality, and supramolecular assembly. ANGEW, 64(11), e202424991. (www)

  @article{ , abstract = {Quintulene is a quintuply symmetrical cycloarene with a positively curved molecular geometry. First described by Staab and Sauer in 1984, its successful synthesis was not achieved until 2020. Due to the challenges posed by its positive curvature, structural extensions of quintulene have been studied rarely. In this work, we report the synthesis of a chiral quintulene ( 1 ) featuring five [5]helicene units at its rim constructed through the introduction of steric hindrance. Single-crystal X-ray diffraction analysis confirmed the structure of 1 that showcases a unique chirality combining helicity and rotational symmetry. The enantiomers of 1 were separated and their chiroptical properties were examined, revealing the dissymmetric absorption and luminescence. Additionally, the bowl shape facilitates supramolecular assembly between 1 and fullerenes, with a binding constant to C 60 10-fold higher than to C 70 . This work expands the structural diversity of quintulene and bridges the structures of cycloarenes and multi-helicenes, paving the way for the structural design of chiral cycloarenes.}, archive = {J_ANGEW}, author = {Ling-Xi Huang and Hong-Rui Pan and Jiang-Feng Xing and Xin-Jing Zhao and Ze-Jia Li and Rong-Jie Xie and Yu-Huan Geng and Qing-Song Deng and Yuan-Zhi Tan}, doi = {10.1002/anie.202424991}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202424991}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Helical quintulene: Synthesis, chirality, and supramolecular assembly}, volume = {64}, year = {2025}, }
• (2025). Putting charge transfer degree as a bridge connecting surface-enhanced raman spectroscopy and photocatalysis. ANGEW, 64(11), e202424986. (www)

  @article{ , abstract = {To date, few systematic approach has been established for predicting catalytic performance by analyzing the spectral information of molecules adsorbed on photocatalyst surfaces. Effective charge transfer (CT) between the semiconductor photocatalysts and surface-absorbed molecules is essential for enhancing catalytic activity and optimizing light energy utilization. This study aimed to validate the surface-enhanced Raman spectroscopy (SERS) based on the CT enhancement mechanism in investigating the CT process during semiconductor photocatalytic C−C coupling model reactions. A copper ion doping strategy was employed to simultaneously enhance the SERS effect and catalytic activity of zinc oxide (ZnO) derived from metal-organic framework (MOF). By analyzing molecular fingerprint SERS spectra, we calculated the degree of CT (ρ CT ), revealing that SERS enhancement is attributed to the CT mechanism. In situ SERS spectra confirmed a high correlation between the catalytic activity and ρ CT of ZnO with varying copper ion doping levels. A range of photoelectric and spectroscopic tests validated the effectiveness of SERS in linking CT to photocatalytic performance, consistent with first-principles density functional theory (DFT) simulations. This finding is also validated in other semiconductor materials and catalytic reactions, demonstrating the broad applicability of ρ CT for predicting and evaluating SERS and catalytic activity.}, archive = {J_ANGEW}, author = {Junjie Chen and Mengyuan Li and Xinmeng Wang and Hongye Liu and Wenji Jiang and Bing Zhao and Wei Song}, doi = {10.1002/anie.202424986}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202424986}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Putting charge transfer degree as a bridge connecting surface-enhanced raman spectroscopy and photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Asymmetric functionalization harnessing radical-mediated functional-group migration. ANGEW, 64(11), e202424667. (www)

  @article{ , abstract = {Along with the renaissance of radical chemistry, the past decade has witnessed rapid development in radical-mediated rearrangement reactions. A wide diversity of radical approaches harnessing functional-group migration (FGM) have been devised to enhance both synthetic efficiency and molecular complexity. However, the application of FGM reactions to construct stereogenic centers remains underexplored owing to the inherent challenges of asymmetric radical reactions. In this Minireview, we summarize the emerging area of asymmetric functionalization involving radical-mediated FGM reactions. Enantioselectivity can be regulated by chiral substrates, auxiliaries or reagents, or achieved through asymmetric transition-metal catalysis. This synthetic strategy demonstrates its superiority in the production of valuable complex molecules that are otherwise difficult to obtain by conventional methods.}, archive = {J_ANGEW}, author = {Fushan Chen and Zhu Cao and Chen Zhu}, doi = {10.1002/anie.202424667}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202424667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric functionalization harnessing radical-mediated functional-group migration}, volume = {64}, year = {2025}, }
• (2025). Porous supramolecular crystalline materials for photocatalysis. ANGEW, 64(11), e202424452. (www)

  @article{ , abstract = {Porous supramolecular crystalline materials (PSCMs), such as hydrogen-bonded organic frameworks (HOFs), π frameworks, can be defined as a type of porous supramolecular assemblies stabilized by hydrogen-bonding, π - π stacking and other non-covalent interactions. Benefiting from the unique features of mild synthesis conditions, well-defined and synthetically tailorable structures, easy healing and regeneration, PSCMs have garnered widespread interest in research fields including molecular recognition, sensor, gas storage and separation. Moreover, they have emerged as promising photocatalysts because these PSCMs could be readily endowed with optical function, and the hydrogen-bonding and π-π stacking can offer channels for electron transfer to boost the photocatalytic activity. However, the research on PSCMs for photocatalysis is still at an early stage, and a review on this topic would help to promote the development of supramolecular chemistry. In this Minireview, we first introduce the synthesis methods for PSCMs, and then highlight their advantages in photocatalysis. Subsequently, we summarize the applications of PSCMs in photocatalysis including CO 2 reduction, H 2 evolution, H 2 O 2 production, organic transformation and pollutant degradation, and we put particular emphasis on delineating the structure-performance relationship. At the end, we discuss the challenges and perspectives in developing high-performance PSCM-based photocatalysts.}, archive = {J_ANGEW}, author = {Yun-Nan Gong and Di-Chang Zhong and Tong-Bu Lu}, doi = {10.1002/anie.202424452}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202424452}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porous supramolecular crystalline materials for photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Zeolite blending: A new approach to direct crystallization of aluminosilicate zeolite. ANGEW, 64(11), e202424442. (www)

  @article{ , abstract = {Various synthesis methods for zeolites have been developed to date; however, precise control over aluminum (Al) content remains a significant challenge. For instance, in the case of CON-type zeolites, it is especially difficult to obtain a Si/Al ratio below a value of approximately 100 by direct synthesis, and below approximately 30 by post-treatment. In this study, we have developed a novel direct synthesis method of the CON-type zeolite having desired Al content by applying the interzeolite conversion/interzeolite transformation, wherein precursor zeolites that possess common composite building units (CBUs) with the target zeolite are employed as the Al and Si source. Initially, a single zeolite was utilized as a precursor, resulting in the successful synthesis of a high Al CON-type zeolite (Si/Al=40). Finally, we developed a novel synthesis method of the CON-type zeolite; blending of two types of zeolites, MFI and Beta, as starting material in the IZC method led to the direct crystallization of the CON-type aluminosilicate with high Al content (Si/Al=20).}, archive = {J_ANGEW}, author = {Masato Sawada and Kensuke Okubo and Yao Lu and Samya Bekhti and Hiroto Toyoda and Liang Zhao and Hiroaki Onozuka and Susumu Tsutsuminai and Junko N. Kondo and Hermann Gies and Toshiyuki Yokoi}, doi = {10.1002/anie.202424442}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202424442}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zeolite blending: A new approach to direct crystallization of aluminosilicate zeolite}, volume = {64}, year = {2025}, }
• (2025). Fluoro-fucosylation enables the interrogation of the lea-LecB interaction by BioNMR spectroscopy. ANGEW, 64(11), e202423782. (www)

  @article{ , abstract = {Fucosylation patterns in cell-surface glycans are essential mediators of recognition and signalling. Aberrations in these signatures serve as vital diagnostic markers of disease progression, and so understanding fucose-protein interactions at the molecular level is crucial. Molecular editing of l -fucose (Fuc) at C2 with fluorine provides a platform to reconcile the ubiquity of fucosylation with the paucity of strategies to interrogate site-specific interactions. Through judicious introduction of a pseudo -equatorial fluorine [C(sp 3 )-F] adjacent to the anomeric position, β-selective fucosylation can be achieved with a range of diverse acceptors (>50 : 1): the selectivity of this process can be inverted through changes in the donor scaffold. Reaction development was driven by the desire to construct a fluorinated analogue of Lewis antigen a (F-Le a ), in which fluorine replaces a key OH group at C2. Le a is a ligand for Lectin B (LecB) in the pathogen Pseudomonas aeruginosa and thus delineating the importance of key interactions in this complex has ramifications for drug discovery. Independent syntheses of Le a and F-Le a , and systematic bioNMR analyses with both glycans has unequivocally established the essential role of O2 of fucose in the Le a -LecB complex.}, archive = {J_ANGEW}, author = {Kathrin Siebold and Elena Chikunova and Nils Lorz and Christina Jordan and Alvar D. Gossert and Ryan Gilmour}, doi = {10.1002/anie.202423782}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202423782}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluoro-fucosylation enables the interrogation of the lea-LecB interaction by BioNMR spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Cobalt-catalyzed hydroglycosylation of alkynes for the synthesis of vinyl α-C-glycosides. ANGEW, 64(11), e202423631. (www)

  @article{ , abstract = {Herein we report a cobalt-catalyzed hydroglycosylation of terminal alkynes, employing bench-stable ortho -iodobiphenyl ( o IB) substituted sulfides as glycosyl donors. This reaction occurs with high stereo- and regioselectivity to afford E -configured vinyl α - C -glycosides, a class of compounds nontrivial to access by previous methods. The use of a bis(oxazoline) ligand with bulky side chains is critical for the high selectivities observed. Aryl iodides have not been used previously as surrogates for alkyl (glycosyl) electrophiles in Co−H catalyzed reactions. The transformation features mild reaction conditions, simple reagents, and broad substrate scope. This method can be applied to the derivatization of bioactive compounds and the preparation of naturally occurring products. Mechanistic studies suggest this stereoconvergent process involves glycosyl radicals as key reaction intermediates.}, archive = {J_ANGEW}, author = {Jia-Xi Wang and Yuan Yao and Yingwei Wang and Dawen Niu}, doi = {10.1002/anie.202423631}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202423631}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-catalyzed hydroglycosylation of alkynes for the synthesis of vinyl α-C-glycosides}, volume = {64}, year = {2025}, }
• (2025). Meta-hydroxylation of pyridines, quinolines, and isoquinolines using dearomatized intermediates. ANGEW, 64(11), e202423512. (www)

  @article{ , abstract = {The functionalization of C−H bonds in heterocycles holds considerable importance in chemical synthesis and drug discovery. Recently, the regioselective introduction of various functionalities at the meta -position of azines, utilizing readily accessible dearomatized intermediates, has emerged as a highly attractive approach. Along these lines, the meta -hydroxylation of azines is an appealing but challenging transformation due to the inherent electronic nature of these heterocycles. Herein, we report a meta -selective hydroxylation of pyridines, quinolines and isoquinolines through easily accessible oxazinoaza-arene intermediates. The nucleophilic C3-position of these dienamine-type intermediates engages in highly regioselective hydroxylation upon treatment with electrophilic peroxides.}, archive = {J_ANGEW}, author = {Debkanta Bhattacharya and Armido Studer}, doi = {10.1002/anie.202423512}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202423512}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Meta-hydroxylation of pyridines, quinolines, and isoquinolines using dearomatized intermediates}, volume = {64}, year = {2025}, }
• (2025). Pd-catalyzed skeletal rearrangement via C(sp3)−C(sp3) activation to access α,β-unsaturated δ/γ-lactone. ANGEW, 64(11), e202423175. (www)

  @article{ , abstract = {The activation of non-polar aliphatic C−C bonds represents a significant challenge that remains to be addressed in the field of Pd(II) catalysis. In this study, we present a dual ligand approach as a means of addressing this issue. The process entails lactonization of cyclobutane and cyclopropane carboxylic acid via the activation of non-polar C( sp 3 )−C( sp 3 ) bond despite the high feasibility of both οrtho -C( sp 2 )−H and β or γ -C( sp 3 )−H activation. Density Functional Theory (DFT) calculations were performed to reveal the mechanistic insights and elucidate the role of dual ligands in facilitating this challenging transformation.}, archive = {J_ANGEW}, author = {Kartic Manna and Suman Maji and Akhilesh Sharma and Nikunj Kumar and Puneet Gupta and Debabrata Maiti}, doi = {10.1002/anie.202423175}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202423175}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pd-catalyzed skeletal rearrangement via C(sp3)−C(sp3) activation to access α,β-unsaturated δ/γ-lactone}, volume = {64}, year = {2025}, }
• (2025). High pressure synthesis of Pr2O5 – A unique Lanthanoid(IV) oxide peroxide. ANGEW, 64(11), e202422929. (www)

  @article{ , abstract = {Reacting praseodymium(IV) oxide with oxygen at 27 GPa in a diamond anvil cell yielded the oxide peroxide Pr 2 IV (O 2 )O 3 , which was characterized by single crystal X-ray diffraction on multi-grain samples, Raman spectroscopy and quantum theoretical calculations at various pressure points. The presence of tetravalent praseodymium ions is supported by electronic structure calculations, showing a band gap of ca. 1.2 eV, which is consistent with the anticipated chemical model of an ionic solid. Pr 2 (O 2 )O 3 thus far represents the most oxygen rich phase of any binary compound of a lanthanoid and oxygen and is the first example of a peroxide anion next to Pr 4+ . Additionally, these results demonstrate that instead of oxidizing the praseodymium ions past their +IV oxidation state, oxygen undergoes a comproportionation to form peroxide anions. Direct oxidation of the oxide anions by Pr 4+ -ions was ruled out by a control experiment in argon instead of oxygen, where no oxidation of oxide ions was observed.}, archive = {J_ANGEW}, author = {Niko T. Flosbach and Lukas Brüning and Pascal L. Jurzick and Elena Bykova and Marcus Ekholm and Igor A. Abrikosov and Mohammad Amirabbasi and Mohamed Mezouar and Björn Wehinger and Nico Giordano and Timofey Fedotenko and Vitali Prakapenka and Stella Chariton and Mathias S. Wickleder and Maxim Bykov}, doi = {10.1002/anie.202422929}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202422929}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High pressure synthesis of Pr2O5 – A unique Lanthanoid(IV) oxide peroxide}, volume = {64}, year = {2025}, }
• (2025). Contrasting mechanochromic luminescence of enantiopure and racemic pyrenylprolinamides: Elucidating solid-state excimer orientation by circularly polarized luminescence. ANGEW, 64(11), e202422913. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) and mechanochromic luminescence (MCL) have independently made substantial progress in recent years. However, the exploration of MCL in solid-state CPL materials, which holds practical significance, is still in its infancy. Herein, we report the MCL properties of readily accessible chiral pyrenylprolinamides bearing tert -butoxycarbonyl (Boc) or 2,2,2-trichloroethoxycarbonyl (Troc) groups. Enantiopure crystals of the Boc derivative display a greater MCL wavelength shift than racemic crystals, while the Troc derivative exhibit the opposite trend. Most notably, the enantiopure crystals show mechanochromic CPL. Unlike in previous examples, where CPL is quenched upon amorphization, robust CPL spectra were observed even in the amorphous states. By applying the excimer chirality rule, we have, for the first time, acquired insights into the excited-state structures within mechanically generated amorphous states. These findings offer a novel design strategy for developing mechanochromic CPL materials, paving the way for the future advancements in this emerging field.}, archive = {J_ANGEW}, author = {Suguru Ito and Shin Wakiyama and Hao Chen and Masato Abekura and Hidehiro Uekusa and Ryoya Ikemura and Yoshitane Imai}, doi = {10.1002/anie.202422913}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202422913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Contrasting mechanochromic luminescence of enantiopure and racemic pyrenylprolinamides: Elucidating solid-state excimer orientation by circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Porphyrin-based covalent organic frameworks for CO2 Photo/Electro-reduction. ANGEW, 64(11), e202422814. (www)

  @article{ , abstract = {Photo/electro-catalytic CO 2 reduction into high-value products are promising strategies for addressing both environmental problems and energy crisis. Duo to their advantageous visible light absorption ability, adjustable optic/electronic properties, definite active center, post-modification capability, and excellent stability, porphyrin-based covalent organic frameworks (COFs) have emerged as attractive photo/electro-catalysts towards CO 2 reduction. In this review, the research progress of the porphyrin-based COFs for photo/electro-catalytic CO 2 reduction is summarized including the design principles, catalytic performance, and reaction mechanism. In addition, this review also presents some challenges and prospects for the application of porphyrin-based COFs in photo/electro-catalytic CO 2 reduction, laying the base for both fundamental research and application efforts.}, archive = {J_ANGEW}, author = {Tingting Sun and Zhi Wang and Yuhui Wang and Qingmei Xu and Kang Wang and Jianzhuang Jiang}, doi = {10.1002/anie.202422814}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202422814}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porphyrin-based covalent organic frameworks for CO2 Photo/Electro-reduction}, volume = {64}, year = {2025}, }
• (2025). Cu(I)-catalyzed enantioselective epoxidation of aldehydes with α-trifluoromethyl diazosilanes. ANGEW, 64(11), e202422020. (www)

  @article{ , abstract = {Catalytic epoxidation of readily available aldehydes with diazo compounds is an atom economical strategy to synthesize epoxides. However, the asymmetric epoxidation reaction of aldehydes and fluorinated diazo compounds is challenging, because of the severe racemic background reaction. Herein, we report the first Cu(I)-catalyzed enantioselective epoxidation reaction between aldehydes and α-trifluoromethyl diazosilanes for the synthesis of chiral trifluoromethyl epoxides. This reaction features mild conditions, broad substrate scope, excellent diastereoselectivity and enantioselectivity. The observed positive nonlinear effect supports the ligand acceleration and the achievement of high enantioselectivity with a chiral ligand possessing lower enantiopurity. The gram scale reaction and down-stream transformation based on the removable silyl group demonstrated the synthetic potential of the reaction.}, archive = {J_ANGEW}, author = {Weilu Zhang and Suo Chen and Yunxiao Zhang and Shanshan Liu and Xiao Shen}, doi = {10.1002/anie.202422020}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202422020}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cu(I)-catalyzed enantioselective epoxidation of aldehydes with α-trifluoromethyl diazosilanes}, volume = {64}, year = {2025}, }
• (2025). Modulating built-in electric field strength in Ru/RuO2 interfaces through ni doping to enhance hydrogen conversion at ampere-level current. ANGEW, 64(11), e202421869. (www)

  @article{ , abstract = {Improving the alkaline hydrogen evolution reaction (HER) efficiency is essential for developing advanced anion exchange membrane water electrolyzers (AEMWEs) that operate at industrial ampere-level currents. Herein, we employ density functional theory (DFT) calculations to identify Ni-RuO 2 as the leading candidate among various 3d transition metal-doped M-RuO 2 (where metal M includes Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, and Zn). The incorporation of Ni atoms facilitates the partial reduction of RuO 2 , resulting in the formation of a Ni−Ru/RuO 2 interface having a significant built-in electric field (BIEF) during electrochemical reactions. The resulted BIEF enhances electron transfer across the interface, which is critical in lowering energy barriers and accelerating the hydrogen evolution reaction (HER) kinetics. As a result, the Ni-RuO 2 catalyst exhibits an overpotential of 134 mV at 1 A cm −2 and a low Tafel slope of 20.85 mV dec −1 , with just 0.03 mg cm −2 of Ru loading. The highly effective BIEF, therefore, plays a pivotal role in the catalyst‘s remarkable performance, allowing the Ni-RuO 2 -based AEMWE to require only 1.71 V to maintain stable operation at 1 A cm −2 over a 1000-hour period.}, archive = {J_ANGEW}, author = {Tao Liu and Lianqin Wang and Bin Chen and Haotian Liu and Sipu Wang and Yingjie Feng and Junfeng Zhang and Yan Yin and Michael D. Guiver}, doi = {10.1002/anie.202421869}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating built-in electric field strength in Ru/RuO2 interfaces through ni doping to enhance hydrogen conversion at ampere-level current}, volume = {64}, year = {2025}, }
• (2025). High-throughput design of single-atom catalysts with nonplanar and triple pyrrole-N coordination for highly efficient H2O2 electrosynthesis. ANGEW, 64(11), e202421864. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) with nonplanar configurations possess unique capabilities for tailoring the oxygen reduction reaction (ORR) catalytic performance compared with the ones with planar configurations, owing to the additional orbital rearrangement arising from the asymmetric coordination atoms. However, the systematic investigation of these nonplanar SACs has long been hindered by the difficulty in screening feasible nonplanar configurations and precisely controlling the coordination structures. Herein, we demonstrate a combined high-throughput screening and experimental verification of nonplanar SACs (ppy-MN 3 ) with metal atoms triple-coordinated by pyrrole-N, for highly active and selective 2e − ORR electrocatalysis. With the additional p -orbital rearrangement of N-ligands for ppy-MN 3 during catalysis, a new descriptor on the energy difference between d-band center of metal sites and p -band centers of N-ligands (Δϵ d−p ) is proposed to accurately identify the relationship between their catalytic activities and electronic structures, on top of the conventional d -band center theory. Consequently, ppy-ZnN 3 is identified with excellent 2e − ORR activity (η=0.08 eV) and selectivity, as well as a low 2e − ORR kinetic barrier under alkaline condition owing to a strong hydrogen bonding between OOH* intermediate and interfacial water, which is then experimentally verified by its high electrocatalytic H 2 O 2 yield (43 mol g −1 h −1 ) and selectivity (92 %) under alkaline condition. This study thus presents a proof-of-concept demonstration of the performance-oriented and precise coordination design of nonplanar SACs for efficient H 2 O 2 electrosynthesis, and, more importantly, provides an essential complement to the d -band theory for more accurately predicting the catalytic activities of catalysts with nonplanar configurations for series potential electrochemical processes.}, archive = {J_ANGEW}, author = {Jingjing Jia and Zhenxin Li and Zhiyuan Sang and Xiaoqing Liu and Wei Peng and Rui Chen and Qiao Jiang and Xia Li and Zhizhen Ren and Weichang Hao and Lichang Yin and Jiachen Liu and Feng Hou and Ji Liang}, doi = {10.1002/anie.202421864}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-throughput design of single-atom catalysts with nonplanar and triple pyrrole-N coordination for highly efficient H2O2 electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Precise manipulation on the structural defects of poly (Triazine imide) single crystals for efficient photocatalytic overall water splitting. ANGEW, 64(11), e202421861. (www)

  @article{ , abstract = {Conjugated polymers, represented by polymeric carbon nitrides (PCNs), have risen to prominence as new-generation photocatalysts for overall water splitting (OWS). Despite considerable efforts, achieving highly crystalline PCNs with minimal structural defects remains a great challenge, and it is also difficult to examine the exact impact of complex defect states on OWS process, which largely limits their quantum efficiency. Herein, we devise a ‘in-situ salt flux’ assisted copolymerization protocol by using nitrogen-rich and nitrogen-deficient monomers to precisely manipulate the structural defects of poly (triazine imide) (PTI) single crystals. Stoichiometric control between two comonomers enables continuous tunning of carbon- and nitrogen-vacancies within PTI, allowing the construction of a series of PTI crystals with different defect states. Theoretical and experimental results unveil the carbon vacancies are related with the radiative decay of excitons, while the nonradiative decay is mainly derived from the nitrogen vacancies. Owing to the effective suppression of both radiative and nonradiative losses, the as-synthesized PTI achieves a record apparent quantum efficiency of 37.8 % by one-step-excitation OWS. This work highlights the significance of rational control of the structural defects and describes clear structure-property-activity relationships in PTI photocatalyst, offering guidance for the development of polymer photocatalysts for solar fuel production.}, archive = {J_ANGEW}, author = {Hangyu Zhuzhang and Xiaocong Liang and Jiaxiang Li and Sikang Xue and Yifan Lin and Baisheng Sa and Sibo Wang and Guigang Zhang and Zhiyang Yu and Xinchen Wang}, doi = {10.1002/anie.202421861}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421861}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise manipulation on the structural defects of poly (Triazine imide) single crystals for efficient photocatalytic overall water splitting}, volume = {64}, year = {2025}, }
• (2025). Dynamically stable Cu0Cuδ+ pair sites based on in situ-exsolved cu nanoclusters on CaCO3 for efficient CO2 electroreduction. ANGEW, 64(11), e202421860. (www)

  @article{ , abstract = {Copper-based catalysts are the choice for producing multi-carbon products (C 2+ ) during CO 2 electroreduction (CO 2 RR), where the Cu 0 Cu δ+ pair sites are proposed to be synergistic hotspots for C−C coupling. Maintaining their dynamic stability requires precise control over electron affinity and anion vacancy formation energy, posing significant challenges. Here, we present an in situ reconstruction strategy to create dynamically stable Cu 0 Cu 0.18+ OCa motifs at the interface of exsolved Cu nanoclusters and CaCO 3 nanospheres (Cu/CaCO 3 ). In situ XAFS analysis confirmed the low-valency state of Cu δ+ during CO 2 RR. DFT calculations demonstrated that the nanocluster size arises from the balance between metal-support interactions and Cu−Cu cohesive energy, while the dynamic stability of rich interfacial Cu δ+ sites is attributed to their low electron affinity and high CO 3 2− vacancy formation energy, which collectively contribute to reduced reducibility. The transformed Cu/CaCO 3 exhibits an impressive C 2+ Faradaic efficiency of 83.7 % at a partial current density of 393 mA cm −2 , facilitated by adsorption of *CO with varying electronegativity at heterogeneous copper sites that lowers the C−C coupling energy barrier. Our findings establish insoluble carbonate as an effective anion pairing for Cu 0 Cu δ+ sites, highlighting the effectiveness of the in situ reconstitution strategy in producing a high density of dynamically stable Cu 0 Cu δ+ pair sites.}, archive = {J_ANGEW}, author = {Rongrong Zhang and Haibin Ma and Shuhe Han and Zhitan Wu and Xin Zhou and Zhongxin Chen and Jia Liu and Yukun Xiao and Wei Chen and Kian Ping Loh}, doi = {10.1002/anie.202421860}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421860}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamically stable Cu0Cuδ+ pair sites based on in situ-exsolved cu nanoclusters on CaCO3 for efficient CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Chiroptical response of carbon nanocages enhanced by achiral guests. ANGEW, 64(11), e202421859. (www)

  @article{ , abstract = {Opening up [60]fullerene makes itself inherently chiral without loss of congenital π-conjugation. An immoderately large aperture on [60]fullerene, however, renders the molecule less rigid and therefore it would reduce dissymmetry factors. Herein, we examined supramolecular technique in geometrical reinforcement of chiral open-[60]fullerenes by encasing achiral guests such as Ar, CO 2 , and CH 3 CN. At a lowest-energy transition, we confirmed a guest-dependency on chiroptical responses with increasing a dissymmetry factor by nearly twice to three times. It should be noted that the guests play a negligible role in electronic structures of the carbon cages. Instead, they are engaged in preclusion of an orifice shrinking not to reduce chiroptical response.}, archive = {J_ANGEW}, author = {Yoshifumi Hashikawa and Koki Fujimura and Yoshihiro Ueda and Norihisa Fukaya and Takeo Kawabata and Yasujiro Murata}, doi = {10.1002/anie.202421859}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421859}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiroptical response of carbon nanocages enhanced by achiral guests}, volume = {64}, year = {2025}, }
• (2025). Amplified cascade catalysis for RAFT polymerization. ANGEW, 64(11), e202421851. (www)

  @article{ , abstract = {We report a conceptually new amplified cascade catalysis that converts oxygen to hydroxyl radical for controlled RAFT polymerization. This catalysis consists of two sequential reactions, deoxygenation catalyzed by glucose oxidase and Fenton reaction catalyzed by ferrocene. The two catalysts can communicate with each other, leading to ferrocene recycling and hence amplification in radical generation. Ferrocene recycling was confirmed by UV/Vis spectroscopy, molecular docking simulation, electron paramagnetic resonance spectroscopy, as well as polymerization studies. This catalysis was applied to RAFT polymerization of various monomers, yielding well-defined homopolymers and diblock copolymers with controlled molecular weights and low dispersities. Poly( N , N -dimethyl acrylamide) with molecular weight over 1 million g mol −1 was also successfully synthesized under ambient conditions. Ferrocene-functionalized microspheres were prepared and used as recyclable Fenton catalyst for five consecutive polymerizations with minimal declination in monomer conversion, which further improved the ecofriendly character of this polymerization methodology.}, archive = {J_ANGEW}, author = {Yue Zhao and Shudi Zhang and Zesheng An}, doi = {10.1002/anie.202421851}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421851}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amplified cascade catalysis for RAFT polymerization}, volume = {64}, year = {2025}, }
• (2025). Light-driven carbon fixation using photosynthetic organelles in artificial photosynthetic cells. ANGEW, 64(11), e202421827. (www)

  @article{ , abstract = {Building an artificial photosynthetic cell from scratch helps to understand the working mechanisms of chloroplasts. It is a challenge to achieve carbon fixation triggered by photosynthetic organelles in an artificial cell. ATP synthase and photosystem II (PSII) are purified and reconstituted onto the phospholipid membrane to fabricate photosynthetic organelles. With the integration of phycocyanin, the ATP production yield increases by 2.51-fold due to the enhanced light harvesting capability. The carbon fixation pathway is established by converting α-oxoglutarate to acetyl-CoA and oxaloacetate with cascade enzyme reactions including the isocitrate dehydrogenase (IDH), aconitase (ACO), and ATP citrate lyase (ACL). The photosynthetic organelles, phycocyanin, and carbon fixation pathway are encapsulated into giant unilamellar vesicles to obtain artificial photosynthetic cells, which convert α-oxoglutarate to acetyl-CoA and oxaloacetate inside artificial cells upon light irradiation. The acetyl-CoA is the most important intermediate product in the cellular metabolic networks for the synthesis of cholesterol and fatty acids. Our results provide a way for efficient light energy conversion to produce ATP and fix CO 2 , and pave the path to build autonomous artificial cells with more complicated metabolic networks.}, archive = {J_ANGEW}, author = {Weichen Wang and Jingjing Zhao and Boyu Yang and Chao Li and Yongshuo Ren and Shubin Li and Xiangxiang Zhang and Xiaojun Han}, doi = {10.1002/anie.202421827}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421827}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-driven carbon fixation using photosynthetic organelles in artificial photosynthetic cells}, volume = {64}, year = {2025}, }
• (2025). Design of high-performance infrared nonlinear optical PAs3S3 with perfectly aligned polar molecular cage via a bipolar-axis-symmetry coupling strategy. ANGEW, 64(11), e202421825. (www)

  @article{ , abstract = {Strong polar molecular cages have recently emerged as novel functional building units for high-performance infrared nonlinear optical (IR NLO) crystals. However, these highly polar molecular cages often arrange themselves in a way that cancels out their polarity, leading to a more energetically stable state. As a result, most cage crystal formations tend to crystallize in centrosymmetric space groups, which conflicts with the primary requirement for NLO crystals. Herein, we address the challenge of polar molecular cage arrangement through bipolar-axis-symmetry coupling strategy, utilizing classical NLO parent compounds. By substituting the C 3v symmetric [B 3 O 6 ] groups with polar C 3v symmetric [PAs 3 S 3 ] cages within the β -BBO polar aixs lattice, we successfully synthesized a new compound, PAs 3 S 3 (PAS), which exhibits a consistent arrangement of polar molecular cages — crucial for maximizing NLO performance. Additionally, due to the non-covalent interactions among [PAs 3 S 3 ] polar molecular cages, PAS demonstrates an unexpectedly strong second harmonic generation (SHG) about 8 times that of AgGaS 2 , along with a significant band gap of 2.75 eV. Furthermore, PAS exhibits remarkable stability against air and moisture. These findings validate our design strategy and position PAS as a promising candidate for applications in IR NLO crystals.}, archive = {J_ANGEW}, author = {Chao Wang and Chensheng Lin and Xin Zhao and Shunda Yang and Tao Yan and Shenghao Fang and Lingli Wu and Ning Ye and Min Luo}, doi = {10.1002/anie.202421825}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421825}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of high-performance infrared nonlinear optical PAs3S3 with perfectly aligned polar molecular cage via a bipolar-axis-symmetry coupling strategy}, volume = {64}, year = {2025}, }
• (2025). Nitrogen-rich conjugated macrocycles: Synthesis, conductivity, and application in electrochemical CO2 capture. ANGEW, 64(11), e202421822. (www)

  @article{ , abstract = {Here we report a series of nitrogen-rich conjugated macrocycles that mimic the structure and function of semiconducting 2D metal–organic and covalent organic frameworks while providing greater solution processability and surface tunability. Using a new tetraaminotriphenylene building block that is compatible with both coordination chemistry and dynamic covalent chemistry reactions, we have synthesized two distinct macrocyclic cores containing Ni−N and phenazine-based linkages, respectively. The fully conjugated macrocycle cores support strong interlayer stacking and accessible nanochannels. For the metal–organic macrocycles, good out-of-plane charge transport is preserved, with pressed pellet conductivities of 10 −3 S/cm for the nickel variants. Finally, using electrochemically mediated CO 2 capture as an example, we illustrate how colloidal phenazine-based organic macrocycles improve electrical contact and active site electrochemical accessibility relative to bulk covalent organic framework powders. Together, these results highlight how simple macrocycles can enable new synthetic directions as well as new applications by combining the properties of crystalline porous frameworks, the processability of nanomaterials, and the precision of molecular synthesis.}, archive = {J_ANGEW}, author = {Phuong H. Le and Andong Liu and Leo B. Zasada and Jackson Geary and Ashlyn A. Kamin and Devin S. Rollins and Hao A. Nguyen and Audrey M. Hill and Yayuan Liu and Dianne J. Xiao}, doi = {10.1002/anie.202421822}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421822}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitrogen-rich conjugated macrocycles: Synthesis, conductivity, and application in electrochemical CO2 capture}, volume = {64}, year = {2025}, }
• (2025). Boosting electrocatalytic nitrate reduction through enhanced mass transfer in cu-bipyridine 2D covalent organic framework films. ANGEW, 64(11), e202421821. (www)

  @article{ , abstract = {Electrocatalytic nitrate reduction (NO 3 RR) is a promising method for pollutant removal and ammonia synthesis and involves the transfer of eight electrons and nine protons. As such, the rational design of catalytic interfaces with enhanced mass transfer is crucial for achieving high ammonia yield rates and Faradaic efficiency (FE). In this work, we incorporated a Cu-bipyridine catalytic interface and fabricated crystalline 2D covalent organic framework films with significantly exposed catalytic sites, leading to improved FE and ammonia yield (FE=92.7 %, NH 3 yield rate=14.9 mg ⋅ h −1 cm −2 in 0.5 M nitrate) compared to bulk catalysts and outperforming most reported NO 3 RR electrocatalysts. The film-like morphology enhances mass transfer across the Cu-bipyridine interface, resulting in superior catalytic performance. We confirmed the reaction pathway and mechanism through in situ characterizations and theoretical calculations. The Cu sites act as primary centers for adsorption and activation, while the bipyridine sites facilitate water adsorption and dissociation, supplying sufficient H* and accelerating proton-coupled electron transfer kinetics. This study provides a viable strategy to enhance mass transfer at the catalytic interface through rational morphology control, boosting the intrinsic activity of catalysts in the NO 3 RR process.}, archive = {J_ANGEW}, author = {Ying Zhu and Haiyan Duan and Christoph G. Gruber and Wenqiang Qu and Hui Zhang and Zhenlin Wang and Jian Zhong and Xinhe Zhang and Lupeng Han and Danhong Cheng and Dana D. Medina and Emiliano Cortés and Dengsong Zhang}, doi = {10.1002/anie.202421821}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421821}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting electrocatalytic nitrate reduction through enhanced mass transfer in cu-bipyridine 2D covalent organic framework films}, volume = {64}, year = {2025}, }
• (2025). Mass transfer-enhanced photothermal membranes with synergistic light utilization for high-turbidity wastewater purification. ANGEW, 64(11), e202421800. (www)

  @article{ , abstract = {The photo-Fenton process faces significant limitations in treating high-turbidity, colored wastewater due to light attenuation and impurity interference (blocked mass transfer). To address these issues, we developed a suspended photothermal Fenton membrane by loading a photothermal catalyst on a hydrophobically modified cotton filter paper, enabling precise suspension 1 mm below the water surface. This design achieved 89.49 % light utilization and high chemical oxygen demand (COD) removal, even in wastewater with extreme chromaticity (10 multiples) and turbidity (703 NTU). The enhanced photothermal conversion accelerated molybdenum co-catalyzed Fenton reactions and improved peroxymonosulfate (PMS) activation, maintaining over 90 % phenol removal for 15 days. Mechanistic simulations revealed improved mass transfer of reactive oxygen species (ROS) and pollutants at the solid–liquid interface, with PMS diffusion identified as the rate-limiting step. The membrane resisted fouling from suspended solids and maintained stable operation in soil-containing solutions for 10 days. This innovative approach offers an efficient solution for degrading pollutants in dark-colored, high-turbidity wastewater, overcoming traditional process limitations.}, archive = {J_ANGEW}, author = {Jiangchen Fu and Shaoze Xiao and Jiazhen Cao and Zhiyan Liang and Jiabin Chen and Yue Jiang and Mingyang Xing}, doi = {10.1002/anie.202421800}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421800}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mass transfer-enhanced photothermal membranes with synergistic light utilization for high-turbidity wastewater purification}, volume = {64}, year = {2025}, }
• (2025). Constrained heterogeneous CoFe2O4/ZnO/PMS fenton-like system for industrial wastewater remediation with recyclability and zero metal loss. ANGEW, 64(11), e202421797. (www)

  @article{ , abstract = {Although heterogeneous Fenton-like processes have attracted widespread attention in wastewater treatment, the mass leached active ions lead to secondary pollution and confuse the demarcation of reaction region. By constructing a constrained completely heterogeneous system and highlighting its reaction region concentrated within the slipping plane of particles, this work achieves efficient organic pollutants degradation without leaching of any free active metal components. Based on the Poisson–Boltzmann equation and electric double layer model, the specific existing of the constrained region is confirmed, and this neglected reaction region between solid interface and slipping plane in traditional heterogeneous Fenton-like reaction is clarified firstly. Due to the unique constrained property, this system demonstrates exceptional potentials application to natural water and actual industrial wastewater for its broad resistance to environmental interference. Furthermore, the alkalization aging process enables this system achieve catalyst recycle and zero metal ions emission with maintaining outstanding pollutants removing performance even in high-salt wastewater, exhibiting the superiority of the constrained completely heterogeneous system. This work demonstrated the important reaction region within slipping plane and provided a clearer boundary in heterogeneous Fenton-like system.}, archive = {J_ANGEW}, author = {Ming Yang and Wenyuan Liu and Qi Liu and Zhuan Chen and Jiazhen Cao and Jinming Luo and Mingyang Xing}, doi = {10.1002/anie.202421797}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421797}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constrained heterogeneous CoFe2O4/ZnO/PMS fenton-like system for industrial wastewater remediation with recyclability and zero metal loss}, volume = {64}, year = {2025}, }
• (2025). T2 occupancy as an effective and predictive descriptor for the design of high-performance spinel oxide peroxidase-like nanozymes. ANGEW, 64(11), e202421790. (www)

  @article{ , abstract = {Nanozymes are next generation of enzyme mimics. Due to the lack of activity descriptors, most nanozymes were discovered through trial-and-error strategies or by accident. While e g occupancy in an octahedral crystal field was proven as an effective descriptor, the t 2 in a tetrahedral crystal field has rarely been explored. Here, we first identified t 2 occupancy as an effective and predictive descriptor. Then, we predicted and demonstrated that spinel oxide nanozymes (AB 2 O 4 ) with a t 2 occupancy of around 4.4 at A site had the highest activity. Furthermore, we introduced O β content as a secondary descriptor. The dual descriptor strategy resulted in a three-dimensional volcanic curve, converging at a vertex. To surpass the limitations of volcanic curves, a dual site optimizing strategy was proposed, guiding the optimization of both A and B sites as Cu and Co, respectively. The designed CuCo 2 O 4 exhibited the highest activity, achieving around 100- and 2-fold enhancement compared to initial material and the state-of-the-art spinel oxide nanozyme LiCo 2 O 4 , respectively. Density functional theory calculations provided a theoretical basis for the catalytic process. This work provides a new strategy for the rational design of nanozymes, and t 2 occupancy may also be applicable to the design of other catalysts.}, archive = {J_ANGEW}, author = {Jiang Du and Zhenzhen Wang and Quan Wang and Xiang Gu and Xingfa Gao and Hui Wei}, doi = {10.1002/anie.202421790}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {T2 occupancy as an effective and predictive descriptor for the design of high-performance spinel oxide peroxidase-like nanozymes}, volume = {64}, year = {2025}, }
• (2025). Directing zn growth with biased adsorption of straight-chain molecules for superior zn anode stability. ANGEW, 64(11), e202421787. (www)

  @article{ , abstract = {Aqueous zinc ion batteries (AZIBs), which have attracted attentions in the field of energy storage, is affected by dendrites and side reactions of Zn anode, resulting in an unsatisfactory performance of AZIBs. Herein, we propose a biased adsorption strategy mediated by straight-chain molecule (Scm) for stabilizing Zn anode. The dual polar termini of Scms guaranties securely anchor themselves in a parallel orientation upon the Zn anode surface. This provides a comprehensive coverage, effectively sequestering water molecules from the Zn anode and precipitating the formation of a water-depleted electric double layer (EDL). Furthermore, the Scms selectively adsorb along the crystallographic planes, guiding the deposition of Zn 2+ . Consequently, the incorporation of these Scms successfully mitigates anode corrosion, HER, and dendrites. The Zn||Zn, Zn||Cu and Zn||V 6 O 13 cells with Scms display significantly enhanced electrochemical performance, especially at elevated temperature of 60 °C. This work highlights the potential of cost-effective, straight-chain electrolyte additives for enhancing Zn anode stability.}, archive = {J_ANGEW}, author = {Fangfang Wu and Junkang Zhang and Lu Ma and Pengchao Ruan and Yulong Chen and Shibo Meng and Ruilian Yin and Wenhui Shi and Wenxian Liu and Jiang Zhou and Xiehong Cao}, doi = {10.1002/anie.202421787}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421787}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Directing zn growth with biased adsorption of straight-chain molecules for superior zn anode stability}, volume = {64}, year = {2025}, }
• (2025). Surface-confined disordered hydrogen bonds enable efficient lithium transport in all-solid-state PEO-based lithium battery. ANGEW, 64(11), e202421777. (www)

  @article{ , abstract = {Polyethylene oxide (PEO)-based electrolytes are essential to advance all-solid-state lithium batteries (ASSLBs) with high safety/energy density due to their inherent flexibility and scalability. However, the inefficient Li + transport in PEO often leads to poor rate performance and diminished stability of the ASSLBs. The regulation of intermolecular H-bonds is regarded as one of the most effective approaches to enable efficient Li + transport, while the practical performances are hindered by the electrochemical instability of free H-bond donors and the constrained mobility of highly ordered H-bonding structures. To overcome these challenges, we develop a surface-confined disordered H-bond system with stable donor-acceptor interactions to construct a loosened chain segments/ions arrangement in the bulk phase of PEO-based electrolytes, realizing the crystallization inhibition of PEO, weak coordination of Li + and entrapment of anions, which are conducive to efficient Li + transport and stable Li + deposition. The rationally designed LiFePO 4 -based ASSLB demonstrates a long cycle-life of over 400 cycles at 1.0 C and 65 °C with a capacity retention rate of 87.5 %, surpassing most of the currently reported polymer-based ASSLBs. This work highlights the importance of confined disordered H-bonds on Li + transport in an all-solid-state battery system, paving the way for the future design of polymer-based ASSLBs.}, archive = {J_ANGEW}, author = {You Fan and Oleksandr I. Malyi and Huicai Wang and Xiangxin Cheng and Xiaobin Fu and Jingshu Wang and Haifeng Ke and Huarong Xia and Yanbin Shen and Zhengshuai Bai and Shi Chen and Huaiyu Shao and Xiaodong Chen and Yuxin Tang and Xiaojun Bao}, doi = {10.1002/anie.202421777}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421777}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface-confined disordered hydrogen bonds enable efficient lithium transport in all-solid-state PEO-based lithium battery}, volume = {64}, year = {2025}, }
• (2025). A catch-release strategy for the genomics-driven discovery of antiproliferative furan-functionalized peptides. ANGEW, 64(11), e202421760. (www)

  @article{ , abstract = {Furan-functionalized peptides are of significant pharmacological interest due to their pronounced bioactivities and unique potential for orthogonal bioconjugation and derivatization. However, naturally occurring peptides with furyl side chains are exceedingly rare. This study presents a streamlined method to predict and assess the microbial production of peptides incorporating 3-furylalanine (Fua) moieties. The approach integrates genome mining and the reversible, chemoselective tagging of furyl residues, utilizing their unique Diels–Alder reactivity, for mass-spectrometry-guided identification of candidate compounds. By employing the rhizonin Fua synthase as a bioinformatic handle and through heterologous reconstitution of Fua biosynthesis, we identified previously unknown Fua biosynthetic pathways in diverse bacterial phyla, including actinomycetes, cyanobacteria, actinobacteria, and γ-proteobacteria, suggesting that Fua-containing peptides are remarkably widely distributed. Metabolic profiling by reversible tagging facilitated the detection of Fua-containing metabolites in their native producers. The successful adaptation of this method for solid support enabled the direct enrichment of furyl-substituted peptides from complex mixtures. This multi-pronged approach enabled the discovery and characterization of two novel families of Fua cyclopeptides (rubriamides and typhamides) with potent antiproliferative effects against human tumor cells and nematodes. The innovative catch-and-release strategy, in conjunction with genome mining, represents a valuable tool for the discovery of new furan-substituted natural products.}, archive = {J_ANGEW}, author = {Friedrich J. Ehinger and Kirstin Scherlach and Felix Trottmann and Jonas Fiedler and Ingrid Richter and Christian Hertweck}, doi = {10.1002/anie.202421760}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421760}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A catch-release strategy for the genomics-driven discovery of antiproliferative furan-functionalized peptides}, volume = {64}, year = {2025}, }
• (2025). CO adsorption on a single-atom catalyst stably embedded in graphene. ANGEW, 64(11), e202421757. (www)

  @article{ , abstract = {Confined single metal atoms in graphene-based materials have proven to be excellent catalysts for several reactions and promising gas sensing systems. However, whether the chemical activity arises from the specific type of metal atom or is a direct consequence of the confinement itself remains unclear.}, archive = {J_ANGEW}, author = {Daniele Perilli and Valeria Chesnyak and Aldo Ugolotti and Mirco Panighel and Stefano Vigneri and Francesco Armillotta and Pardis Naderasli and Matus Stredansky and Monika Schied and Paolo Lacovig and Silvano Lizzit and Cinzia Cepek and Giovanni Comelli and Harald Brune and Cristina Africh and Cristiana Di Valentin}, doi = {10.1002/anie.202421757}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421757}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CO adsorption on a single-atom catalyst stably embedded in graphene}, volume = {64}, year = {2025}, }
• (2025). A gate-opening control strategy via Nitrate–Chloride anion exchange for enhanced hydrogen isotope separation in Metal–Organic frameworks. ANGEW, 64(11), e202421756. (www)

  @article{ , abstract = {Efficient separation of hydrogen isotopes, especially deuterium (D 2 ), is pivotal for advancing industries such as nuclear fusion, semiconductor processing, and metabolic imaging. Current technologies, including cryogenic distillation and Girdler sulfide processes, suffer from significant limitations in selectivity and cost-effectiveness. Herein, we introduce a novel approach utilizing an imidazolium-based Metal–Organic Framework (MOF), JCM-1, designed to enhance D 2 /H 2 separation through temperature-dependent gate-opening controlled by ion exchange. By substituting NO 3 − ions in JCM-1(NO 3 − ) with Cl − ions to form JCM-1(Cl − ), we precisely modulate the gate-opening threshold, achieving a significant enhancement in isotope selectivity. JCM-1(NO 3 − ) exhibited a D 2 /H 2 selectivity (S D2/H2 ) of 14.4 at 30 K and 1 bar, while JCM-1(Cl − ) achieved an exceptional selectivity of 27.7 at 50 K and 1 mbar. This heightened performance is attributed to the reduced pore aperture and higher gate-opening temperature resulting from the Cl − exchange, which optimizes the selective adsorption of D 2 . Our findings reveal that JCM-1 frameworks, with their finely tunable gate-opening properties, offer a highly efficient and adaptable platform for hydrogen isotope separation. This work not only advances the understanding of ion-exchanged MOFs but also opens new pathways for targeted applications in isotope separation and other gas separation processes.}, archive = {J_ANGEW}, author = {Hyunlim Kim and Younggyu Seo and Jaewoo Park and Eunsung Lee and Hyunchul Oh}, doi = {10.1002/anie.202421756}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421756}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A gate-opening control strategy via Nitrate–Chloride anion exchange for enhanced hydrogen isotope separation in Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Identifying n coordination types of single-atom catalysts by spin-modulated luminol cathodic electrochemiluminescence. ANGEW, 64(11), e202421755. (www)

  @article{ , abstract = {The type of coordinated N atoms in the metal-N coordination structure is of paramount importance to the catalytic property of N-modified carbon-based single-atom catalysts (SACs). Extended X-ray absorption fine structure (EXAFS) spectroscopy is a powerful tool for analyzing the coordination environments of SACs. Despite its efficacy, the limited availability of synchrotron light sources and the complexity of data analysis have constrained its broader application in identifying metal-N coordination types within SACs. In this work, two kind of CoN 4 SACs, were prepared by varying the N source. Then their electrochemiluminescence (ECL) behavior in the luminol/dissolved oxygen system during cathodic scanning were investigated. In comparison to CoN 4(pyridinic N) , for which the spin density displays d z2 orbital characteristics, CoN 4(pyrrolic N) exhibits d xz orbital features, which was more conducive to the subsequent cleavage of the O−O bond in O 2 ⋅ − to ⋅OH, resulting in the generation of more active intermediates *OH and the promotion of cathodic ECL emission. This work demonstrates that the ECL technique provides a novel method for the rapid identification of Co−N coordination types and the spin nature of the metal center in CoN 4 SACs.}, archive = {J_ANGEW}, author = {Mengru Liu and Mingxin Liu and Wenjie Chen and Feiming Li and Shunyou Cai and Shu-Juan Lin and Xi Chen and Zhixiong Cai}, doi = {10.1002/anie.202421755}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421755}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identifying n coordination types of single-atom catalysts by spin-modulated luminol cathodic electrochemiluminescence}, volume = {64}, year = {2025}, }
• (2025). Photochromic metal-organic frameworks based on host-guest strategy and different viologen derivatives for organic amines sensing and information anticounterfeiting. ANGEW, 64(11), e202421744. (www)

  @article{ , abstract = {The encapsulation of viologen derivatives in metal-organic frameworks (MOFs) to construct host-guest materials has been widely discussed owing to their distinctive spatial arrangement and physical/chemical properties. Herein, three new photochromic MOFs ( NWM-1–3 ) have been successfully synthesized by 1,1,2,2-Tetra(4-carboxylphenyl)ethylene (H 4 TCPE) ligand as well as three different viologen derivatives based on host-guest strategy. Remarkably, NWM-1–3 exhibit a notable reversible photochromism change from yellow to green under 365 nm UV irradiation. The distance between the electron-deficient N atom in the viologens and the electron-rich carboxylate oxygens satisfies the electron transfer (ET) pathway, and thus ET occurs upon irradiation, producing intermolecular viologen radicals. NWM-1 is able to produce colored responses to different volatile amines by ET and can be recognizable to the naked eye. Differential pulse voltammetry (DPV) analysis and comparative experiments have demonstrated that the host-guest strategy significantly enhances the electron-accepting ability of viologens, thereby achieving superior amine sensing performance. NWM-2 and 3 have been realized in various applications, such as security code, fingerprint, and QR codes for anticounterfeiting. This work provides new host-guest strategy for designing highly sensitive photochromic materials and color-tunable luminescent materials, advancing the development of assembled photochromic materials closer to commercialization.}, archive = {J_ANGEW}, author = {Yi-Dan Li and Lu-Fang Ma and Guo-Ping Yang and Yao-Yu Wang}, doi = {10.1002/anie.202421744}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421744}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photochromic metal-organic frameworks based on host-guest strategy and different viologen derivatives for organic amines sensing and information anticounterfeiting}, volume = {64}, year = {2025}, }
• (2025). Selective hydrogen isotope exchange catalysed by simple alkali-metal bases in DMSO. ANGEW, 64(11), e202421736. (www)

  @article{ , abstract = {Isotope Exchange processes are becoming the preferred way to prepare isotopically labelled molecules, avoiding the redesign of multistep synthetic protocols. In the case of deuterium incorporation, the most used strategy has employed transition metals, that offer high reactivity under mild reaction conditions. Despite their success, the trade-off is that these metals are precious, so expensive, and often exhibit high toxicity. Therefore, alternative transition-metal-free protocols would be a welcome addition to this field. In this report we show how the simple bases NaHMDS (HMDS=hexamethyldisilazide) and NaCH 2 SiMe 3 can efficiently and selectively promote deuteration of a wide range of C(sp 2 )−H and C(sp 3 )−H bonds in DMSO- d 6 , providing an easy and direct access to deuterated compounds. Heterocycles, fluoroarenes, N -heterocyclic carbenes, amides and other aromatic molecules could be deuterated under mild conditions using catalytic amounts of base. Mechanistic studies along with the isolation and characterisation of reaction intermediates have flagged up the importance of the metalated substrate and metalated solvent in solution, establishing an equilibrium between these compounds is crucial for the success of this approach. An alkali-metal effect was observed, with heavier alkali-metal amides being more reactive at room temperature, but their lower stability at higher temperatures made sodium bases the optimal reagents for Hydrogen Isotope Exchange.}, archive = {J_ANGEW}, author = {Melina S. Tschopp and Andreu Tortajada and Eva Hevia}, doi = {10.1002/anie.202421736}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421736}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective hydrogen isotope exchange catalysed by simple alkali-metal bases in DMSO}, volume = {64}, year = {2025}, }
• (2025). Transitioning room-temperature phosphorescence from solid states to aqueous phases via a cyclic peptide-based supramolecular scaffold. ANGEW, 64(11), e202421729. (www)

  @article{ , abstract = {Aqueous room-temperature phosphorescence (RTP) materials have garnered considerable attention for their significant potential across various applications such as bioimaging, sensing, and encryption. However, establishing a universally applicable method for achieving aqueous RTP remains a substantial challenge. Herein, we present a versatile supramolecular strategy to transition RTP from solid states to aqueous phases. By leveraging a cyclic peptide-based supramolecular scaffold, we have developed a noncovalent approach to molecularly disperse diverse organic phosphors within its rigid hydrophobic microdomain in water, yielding a series of aqueous RTP materials. Moreover, high-performance supramolecular phosphorescence resonance energy transfer (PRET) systems have been constructed. Through the facile co-assembly of a fluorescent acceptor with the existing RTP system, these PRET systems exhibit high energy transfer efficiencies (>80 %), red-shifted afterglow emission (520–790 nm), ultralarge Stokes shifts (up to 450 nm), and improved photoluminescence quantum yields (6.1–30.7 %). This study not only provides a general strategy for constructing aqueous RTP materials from existing phosphors, but also facilitates the creation of PRET systems featuring color-tunable afterglow emission.}, archive = {J_ANGEW}, author = {Ruicong Feng and Xianjia Yan and Yufeng Sang and Xindi Liu and Zhi Luo and Zhenhua Xie and Yubin Ke and Qiao Song}, doi = {10.1002/anie.202421729}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421729}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transitioning room-temperature phosphorescence from solid states to aqueous phases via a cyclic peptide-based supramolecular scaffold}, volume = {64}, year = {2025}, }
• (2025). Interface engineering of MOF nanosheets for accelerated redox kinetics in lithium-sulfur batteries. ANGEW, 64(11), e202421726. (www)

  @article{ , abstract = {Modifying the separator is considered as an effective strategy for achieving high performance lithium-sulfur (Li-S) batteries. However, most modification layers are excessively thick, with catalytic active sites primarily located within the material′s interior. This configuration severely impacts Li + transport and the efficient catalytic conversion of polysulfides. Therefore, there is an urgent need to develop a multifunctional separator that integrates ultrathin design, catalytic activity, and ion sieving capabilities. Herein, we successfully linked TCPP(Ni) as a secondary ligand with Zr-BTB nanosheets to create an ultra-thin separator modification layer (Zr-TCPP(Ni)) with efficient ion sieving and catalytic properties. The resultant multifunctional separators provide robust ion sieving capabilities that promote rapid Li + transport and intercept polysulfides shuttling. Therefore, The Zr-TCPP(Ni)@PP cell maintains 70.0 % of its initial capacity after 600 cycles at a high rate of 3 C, while achieving an impressive areal capacity of 4.55 mA h cm −2 even with high sulfur content of 80 wt% at 0.5 C. This work provides valuable insights for rational design of MOF interface engineering in high energy density Li-S batteries.}, archive = {J_ANGEW}, author = {Zhibin Cheng and Yiyang Chen and Jie Lian and Xingli Chen and Shengchang Xiang and Banglin Chen and Zhangjing Zhang}, doi = {10.1002/anie.202421726}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421726}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interface engineering of MOF nanosheets for accelerated redox kinetics in lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Cell-sensing analogue nanopore for rapid detection of protein-related targets. ANGEW, 64(11), e202421721. (www)

  @article{ , abstract = {Nanopores offer significant advantages in biosensing. Conventional nanopore sensors require probe modification within the pore, and there are two major obstacles: inhomogeneity of probe modification within the pore, and distortion of the detection signal due to the uncontrollable dynamics of the target within the pore. Here, we constructed a cell-sensing analogue nanopore (CeSa-nanopore), by coating the outer surface of the nanopore with cell membrane. The inhomogeneity of probe modification and the uncontrollable kinetics of target-probe binding were also addressed. Specific cells are selected to prepare CeSa-nanopore, for example, cells with high expression of angiotensin-converting enzyme 2 (ACE2) are used to achieve the detection of SARS-CoV-2. When SARS-CoV-2 binds to CeSa-nanopore the surface potential changes, causing a change in the ionic current, thus enabling its detection with a detection rate of 100 %. In addition, the detection of different proteins, such as follicle-stimulating hormone (FSH), can be achieved by changing the cell membrane coating. The identification of cancer cells in ascites can also be achieved by utilizing homologous targeting between cancer cells. Importantly, the use of CeSa-nanopores for the detection of these targets eliminates the need for pre-processing and significantly reduces detection time.}, archive = {J_ANGEW}, author = {Jun Dai and Yuxin Hu and Weiyong Liu and Hong Liu and Shixuan Wang and Fan Xia and Xiaoding Lou}, doi = {10.1002/anie.202421721}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421721}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cell-sensing analogue nanopore for rapid detection of protein-related targets}, volume = {64}, year = {2025}, }
• (2025). In vivo self-assembly of PROTACs by bioorthogonal chemistry for precision cancer therapy. ANGEW, 64(11), e202421713. (www)

  @article{ , abstract = {Proteolysis targeting chimeras (PROTACs) hold immense promise for targeted protein degradation; however, challenges such as off-target effects, poor drug-likeness properties, and the “hook effect” remain. This study introduces Nano-Click-formed PROTACs (Nano-CLIPTACs) for precise tumor protein degradation in vivo. Traditional PROTACs with high molecular weight were first divided into two smaller druglike precursors capable of self-assembling to form functional PROTACs through a bioorthogonal reaction. Then, optimal CLIPTACs precursors ( W4 and Z2 ) were encapsulated individually into cyclic RGDfC-peptide-modified liposomes to prepare Nano-CLIPTACs, enabling tumor-targeted delivery and subsequent in situ self-assembly to form PROTACs WZ42 within tumor cells. The degradation abilities of Nano-CLIPTACs in vitro and in vivo were further verified using a key oncology target, anaplastic lymphoma kinase (ALK), validating the safety, efficacy and “anti-hook effect” of this strategy. Overall, Nano-CLIPTACs represent a critical step towards the clinical translation of PROTACs technology for precise targeted anti-cancer therapies.}, archive = {J_ANGEW}, author = {Shaowen Xie and Jingjie Zhu and Yihan Peng and Fangyi Zhan and Feiyan Zhan and Chen He and Dazhi Feng and Jia Xie and Jingyu Liu and Huajian Zhu and Hong Yao and Jinyi Xu and Zhigui Su and Shengtao Xu}, doi = {10.1002/anie.202421713}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421713}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In vivo self-assembly of PROTACs by bioorthogonal chemistry for precision cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Engineering modular peptide nanoparticles for ferroptosis-enhanced tumor immunotherapy. ANGEW, 64(11), e202421703. (www)

  @article{ , abstract = {Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors are promising for treating tumors but have limited efficacy due to the immunosuppressive tumor microenvironment. In this study, we develop an orchestrated nanoparticle system using modular peptide assemblies, where the co-assembled sequences are designed for the specific binding to the hydrophobic and hydrophilic domains, guiding the assembly process and enabling the customization of nanoparticle properties. We exploit the modularity of this platform to integrate a hydrophobic ferroptosis precursor, an IDO1 inhibitor, and a hydrophilic peptidic PD−L1 antagonist for optimizing therapeutic outcomes through ferroptosis-enhanced tumor immunotherapy. The resulting nanoparticles induce immunogenic ferroptosis, enhance the intratumoral function of T lymphocytes, suppress regulatory T cells, and effectively modulate the immunosuppressive tumor microenvironment, thereby facilitating regression of tumor growth. This work provides a modular peptide-based nanoparticle engineering strategy and holds significant potential for advancing cancer treatment.}, archive = {J_ANGEW}, author = {Bihan Wu and Xuejiao Yang and Nan Kong and Juan Liang and Sangshuang Li and Huaimin Wang}, doi = {10.1002/anie.202421703}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421703}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering modular peptide nanoparticles for ferroptosis-enhanced tumor immunotherapy}, volume = {64}, year = {2025}, }
• (2025). C−H bond activation by sulfated zirconium oxide is mediated by a sulfur-centered lewis superacid. ANGEW, 64(11), e202421699. (www)

  @article{ , abstract = {Sulfated zirconium oxide ( SZO ) catalyzes the hydrogenolysis of isotactic polypropylene (iPP, M w =13.3 kDa, Đ =2.4, < mmmm >=94 %) or high-density polyethylene (HDPE, M n =2.5 kDa, Đ =3.6) to branched alkane products. We propose that this reactivity is driven by the pyrosulfate sites SZO , which open under mild conditions to transiently form adsorbed SO 3 and sulfate groups. This adsorbed SO 3 is a very strong Lewis acid that binds 15 N-pyridine or triethylphosphineoxide (TEPO) (Δ E ads >−39 kcal mol −1 ), reacts with Ph 3 CH to form Ph 3 C + , and mediates H/D exchange in dihydroanthracene- d 4 . DFT studies show that pyrosulfate sites open with a modest 26.1 kcal mol −1 barrier to form the adsorbed SO 3 and sulfate in the presence of a tetramer of propylene. Hydride abstraction from the tertiary C−H in this model is exothermic and subsequent β-scission forms cleaved products. Analysis of the energetics provided here brackets the hydride ion affinity (HIA) of the adsorbed SO 3 between 226.2 to 237.9 kcal mol −1 , among largest values reported for a formally neutral Lewis acid. This study explains how SZO , a classic heterogeneous catalyst, can form carbocations by a redox neutral hydride abstraction reaction by very strong Lewis sites.}, archive = {J_ANGEW}, author = {Ratchawi Jammee and Alexander Kolganov and Marc C. Groves and Evgeny A. Pidko and Orson L. Sydora and Matthew P. Conley}, doi = {10.1002/anie.202421699}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421699}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C−H bond activation by sulfated zirconium oxide is mediated by a sulfur-centered lewis superacid}, volume = {64}, year = {2025}, }
• (2025). Flexible fiber sensors for real-time monitoring of redox signaling molecules in exercise-mimicking engineered skeletal muscle. ANGEW, 64(11), e202421684. (www)

  @article{ , abstract = {Real-time monitoring of reactive oxygen and nitrogen species (RONS) in skeletal muscle provides crucial insights into the cause-and-effect relationships between physical activity and health benefits. However, the dynamic production of exercise-induced RONS remains poorly explored, due to the lack of sensing tools that can conform to soft skeletal muscle while monitor RONS release during exercise. Here we introduce dual flexible sensors via twisting carbon nanotubes into helical bundles of fibers and subsequent assembling electrochemical sensing components. These flexible sensors exhibit low bending stiffness, excellent H 2 O 2 and NO sensing abilities, outstanding biocompatibility and compliance with engineered skeletal muscle tissue. This allows real-time and simultaneous monitoring of H 2 O 2 and NO release from engineered skeletal muscle in response to different exercise-mimicking stretches, which reveals that warm-up activities before high-intensity exercise may enhance adaptive responses by down-regulating H 2 O 2 and up-regulating NO production. The proposed sensing strategy demonstrates great versatility in monitoring multiple biomarkers of soft tissue and organs.}, archive = {J_ANGEW}, author = {Jia-Xin Li and Wen-Ting Fan and Meng-Yuan Sun and Yi Zhao and Yi-Fei Lu and Yan-Bing Yang and Wei-Hua Huang and Yan-Ling Liu}, doi = {10.1002/anie.202421684}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flexible fiber sensors for real-time monitoring of redox signaling molecules in exercise-mimicking engineered skeletal muscle}, volume = {64}, year = {2025}, }
• (2025). A hydrolytically stable Metal–Organic framework for simultaneous desulfurization and dehydration of wet flue gas. ANGEW, 64(11), e202421681. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) have great prospects as adsorbents for industrial gas purification, but often suffer from issues of water stability and competitive water adsorption. Herein, we present a hydrolytically stable MOF that could selectively capture and recover trace SO 2 from flue gas, and exhibits remarkable recyclability in the breakthrough experiments under wet flue-gas conditions, due to its excellent resistance to the corrosion of SO 2 and the water-derived capillary forces. More strikingly, its SO 2 capture efficiency is barely influenced by the increasing humidity, even if the pore filling with water is reached. Mechanistic studies demonstrate that the delicate pore structure with diverse pore dimensions and chemistry leads to different adsorption kinetics and thermodynamics as well as segregated adsorption domains of SO 2 and H 2 O. Significantly, this non-competitive adsorption mechanism enables simultaneous desulfurization and dehydration by a single adsorbent, opening an avenue toward cost-effective and simplified processing flowcharts for flue gas purification.}, archive = {J_ANGEW}, author = {Jing-Jing Pang and Zhao-Quan Yao and Hong-Liang Huang and Lin Li and Quan-Wen Li and Nan Lu and Zi-Han Song and Jian Xu and Xian-He Bu}, doi = {10.1002/anie.202421681}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421681}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A hydrolytically stable Metal–Organic framework for simultaneous desulfurization and dehydration of wet flue gas}, volume = {64}, year = {2025}, }
• (2025). Iridium(III) blue phosphors with heteroleptic carbene cyclometalates: Isomerization, emission tuning, and OLED fabrications. ANGEW, 64(11), e202421664. (www)

  @article{ , abstract = {Ir(III) complexes are particularly noted for their excellent photophysical properties in giving blue OLED phosphors. In this study, two distinctive carbene pro-chelates LAH 2 + and LBH 2 + (or LCH 2 + ) were employed in preparation of heteroleptic Ir(III) complexes, to which LAH 2 + bears a cyano substituted benzoimidazolium along with N-mesityl appendage, while LBH 2 + (or LCH 2 + ) carries the symmetrical benzoimidazolium entity. Notably, the reversible equilibration at high temperature was observed for m , f - ct14 and m , f - ct15 with a single LA chelate. In contrast, only the mer -substituted m - ct16 was obtained upon employing two LA chelates. All Ir(III) complexes exhibited blue photoluminescence ( Φ PL 78 %) with short radiative lifetimes (τ rad 1.05 μs) in solution. The Ph OLED device with m - ct16 afforded an external quantum efficiency (EQE) of 22.8 % at 5000 cd ⋅ m −2 . Moreover, the hyper-OLED based on m - ct16 and v-DABNA exhibited EQE 1000 of 32.1 % (EQE recorded at 1000 cd ⋅ m −2 ) and J 90 of 15.0 mA cm −2 (current density at 90 % of max. EQE). Its suppressed efficiency roll-off (EQE of 32.1 % and 27.7 % at 1000 cd ⋅ m −2 and 10000 cd ⋅ m −2 ) demonstrated a milestone in fabrication of blue OLED devices.}, archive = {J_ANGEW}, author = {Yixin Wu and Manli Huang and Lin Cheng and Junyao Zhang and Yi Pan and Shek-Man Yiu and Kai Chung Lau and Jie Yan and Chuluo Yang and Yun Chi}, doi = {10.1002/anie.202421664}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iridium(III) blue phosphors with heteroleptic carbene cyclometalates: Isomerization, emission tuning, and OLED fabrications}, volume = {64}, year = {2025}, }
• (2025). Precise separation of complex ultrafine molecules through solvating two-dimensional covalent organic framework membranes. ANGEW, 64(11), e202421661. (www)

  @article{ , abstract = {Isoporous nanomaterials, with their proven potential for accurate molecular sieving, are of substantial interest in propelling sustainable membrane techniques. Covalent organic frameworks (COFs) are prominent due to their customizable isopores and chemistry. Still, the discrepancy in experimental and theoretical structures poses a challenge to developing COF membranes for molecular separations. Here, we report high-selectivity sieving of complex ultrafine molecules through solvating pore-to-pore-aligned two-dimensional COF membranes. Our structurally oriented membrane shows reversible interlayer expansion with intralayer shift in response to solvent exposure. This dynamic deformation induced by solvents leads to a reduction in the aperture of the membrane's sieving pores, which correlates with the number of COF layers. The resultant membranes yield largely improved molecular selectivity to discriminate binary and trinary complex mixtures, exceeding the conventional COF membranes. The membrane's robustness against solvents and physical aging permits extremely stable microporosity and reliable operation for over 3000 h. This exceptional performance positions our membrane as an alternative to enriching and purifying value-added chemicals, such as active pharmaceutical ingredients.}, archive = {J_ANGEW}, author = {Xiansong Shi and He Li and Ting Chen and Junyu Ren and Wei Zhao and Bidhan Chandra Patra and Chengjun Kang and Zhaoqiang Zhang and Dan Zhao}, doi = {10.1002/anie.202421661}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise separation of complex ultrafine molecules through solvating two-dimensional covalent organic framework membranes}, volume = {64}, year = {2025}, }
• (2025). Lattice modulation on singlet-triplet splitting of silver cluster boosting near-unity photoluminescence quantum yield. ANGEW, 64(11), e202421656. (www)

  @article{ , abstract = {Developing thermally activated delayed fluorescence (TADF)-active silver clusters with near-unity quantum efficiency is of practical importance in cutting-edge optoelectronic devices, but remains a tremendous challenge due to the difficulty of de novo synthesis and uncertainty of properties. Herein, we demonstrate a lattice modulation on parent TADF- active silver cluster, achieving TADF-driven photoluminescence quantum yield (PLQY) from 12 % to near-unity. Systematic experimental and calculated results reveal that the lattice modulation effectively lowers the singlet-triplet splitting (ΔE ST ) from 718 to 549 cm -1 , thereby facilitating thermally activated reverse intersystem crossing: T 5 →S 5 , leading to extremely efficient TADF by surpassing both phosphorescence and non-radiative decay, thus boosting the near-unity PLQY. Such high PLQY is extremely rare in the TADF-active silver clusters and even in the whole noble-metal clusters. This research showcases an unparalleled example of lattice modulation to realize near unity PLQY of TADF-active silver clusters.}, archive = {J_ANGEW}, author = {Wei-Dong Tian and Chengkai Zhang and Sayan Paul and Wei-Dan Si and Zhi Wang and Pan-Pan Sun and Anakuthil Anoop and Chen-Ho Tung and Di Sun}, doi = {10.1002/anie.202421656}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421656}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lattice modulation on singlet-triplet splitting of silver cluster boosting near-unity photoluminescence quantum yield}, volume = {64}, year = {2025}, }
• (2025). Interfacial water orientation in neutral oxygen catalysis for reversible ampere-scale zinc-air batteries. ANGEW, 64(11), e202421640. (www)

  @article{ , abstract = {The neutral oxygen catalysis is an electrochemical reaction of the utmost importance in energy generation, storage application, and chemical synthesis. However, the restricted availability of protons poses a challenge to achieving kinetically favorable oxygen catalytic reactions. Here, we alter the interfacial water orientation by adjusting the Brønsted acidity at the catalyst surface, to break the proton transfer limitation of neutral oxygen electrocatalysis. An unexpected role of water molecules in improving the activity of neutral oxygen catalysis is revealed, namely, increasing the H-down configuration water in electric double layers rather than merely affecting the energy barriers for reaction limiting steps. The proposed porous nanofibers with atomically dispersed MnN 3 exhibit record-breaking activity (E ORR@1/2 /E OER@10 mA = 0.85/1.65 V vs. RHE) and reversibility (2500 h), outperforming all previously reported neutral catalysts and rivaling conventional alkaline systems. In particular, practical ampere-scale zinc-air batteries (ZABs) stack are constructed with a capacity of 5.93 Ah and can stably operate under 1.0 A and 1.0 Ah conditions, demonstrating broad application prospects. This work provides a novel and feasible perspective for designing neutral oxygen electrocatalysts and reveals the future commercial potential in mobile power supply and large-scale energy storage.}, archive = {J_ANGEW}, author = {Yixin Hao and Luqi Wang and Hongjiao Huang and Hao Zhou and Gengyu Xing and Dongxiao Ji and Tianran Zhang and Aoming Huang and Ai-Yin Wang and Xiang-Rong Chen and Tsung-Yi Chen and Han-Yi Chen and Seeram Ramakrishna and Shengjie Peng}, doi = {10.1002/anie.202421640}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial water orientation in neutral oxygen catalysis for reversible ampere-scale zinc-air batteries}, volume = {64}, year = {2025}, }
• (2025). Dynamic passivation of perovskite films via gradual additive release for enhanced solar cell efficiency. ANGEW, 64(11), e202421637. (www)

  @article{ , abstract = {Modifying perovskites with functional additives has proven effective in refining the crystallization process and passivating the defects of perovskite films, thereby ensuring high photovoltaic efficiencies. However, conventional methods that involve pre-mixing additives into the precursor solution often face challenges due to discrepancies in the spatial distribution of slow-diffused additives relative to dynamically formed defect sites, resulting in limited passivation effectiveness. To address this issue, this study innovatively proposes a dynamic passivation strategy that utilizes a pre-passivator to gradually release active additives during the thermal crystallization process of perovskite films. By leveraging the principle of energy minimization, these timely-released additives can interact precisely and selectively with the high-energy defect sites generated during crystallization, thus facilitating efficient additive utilization and in situ real-time defect passivation. Through analysis of crystallization kinetics and carrier dynamic, it is demonstrated that this dynamic passivation approach significantly improves film quality and prolongs carrier lifetime, outperforming traditional pre-mixing tactics. Consequently, the final perovskite solar cell achieves an impressive solar conversion efficiency of 25.33 %, along with exceptional stability. This work provides strong support of tailored additive strategies aimed at further enhancing the efficiency of perovskite solar cells and their subsequent commercial applications.}, archive = {J_ANGEW}, author = {Yujie Zhu and Jing Zhang and Hang Su and Peijun Wang and Yutong She and Xinxin Zheng and Xin Liu and Jiarong Wu and Runkang Wang and Ying Wang and Deng Li and Shengzhong Frank Liu}, doi = {10.1002/anie.202421637}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic passivation of perovskite films via gradual additive release for enhanced solar cell efficiency}, volume = {64}, year = {2025}, }
• (2025). Hour-long afterglow in flexible polymeric materials through the introduction of electron Donor/Acceptor exciplexes. ANGEW, 64(11), e202421634. (www)

  @article{ , abstract = {The development of organic afterglow materials has garnered significant attention due to their diverse applications in smart devices, optoelectronics, and bioimaging. However, polymeric afterglow materials often suffer from short emission lifetimes, typically ranging from milliseconds to seconds, posing a significant challenge for achieving hour-long afterglow (HLA) polymers. This study presents the successful fabrication of transparent HLA polymers by introducing electron donor/acceptor exciplexes. Employing aromatic polyesters as the polymer electron acceptor and charge reservoirs, the resulting HLA polymers exhibited a remarkable green afterglow that persisted for 12 hours under ambient conditions, representing the longest duration achieved for polymeric afterglow materials to date. Intriguingly, these HLA polymers could be activated solely by sunlight, maintaining a green afterglow for over 6 hours at room temperature in air, which outperformed all previously reported afterglow polymers. The doped polymers exhibited superior flexibility and transparency, making them ideal candidates for flexible display applications. Furthermore, successfully spinning these doped polymers into fibers while retaining their HLA properties opens up exciting possibilities for their use in wearable smart devices.}, archive = {J_ANGEW}, author = {Jiaju Shi and Peng Zhang and Haiyang Gao and Fangming Zhu and Guodong Liang}, doi = {10.1002/anie.202421634}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421634}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hour-long afterglow in flexible polymeric materials through the introduction of electron Donor/Acceptor exciplexes}, volume = {64}, year = {2025}, }
• (2025). Enzymatic reaction network-driven polymerization-induced transient coacervation. ANGEW, 64(11), e202421620. (www)

  @article{ , abstract = {A living cell has a highly complex microenvironment whereas numerous enzyme-driven processes are active at once. These procedures are incredibly accurate and efficient, although comparable control has not yet been established in vitro. Here, we design an enzymatic reaction network (ERN) that combines antagonistic and orthogonal enzymatic networks to produce adjustable dynamics of ATP-fueled transient coacervation. Using horseradish peroxidase (HRP)-mediated Biocatalytic Atom Transfer Radical Polymerization (BioATRP), we synthesized poly(dimethylaminoethyl methacrylate), which subsequently formed coacervates with ATP. We rationally explored enzymatic control over coacervation and dissolution, using orthogonal and antagonistic enzyme pairs viz ., alkaline phosphatase, Creatine phosphokinase, hexokinase, esterase, and urease. ATP-fuelled coacervates also demonstrate the enzymatic catalysis to prove its potential to be exploited as a cellular microreactor. Additionally, we developed ERN-polymerization-induced transient coacervation (ERN-PIC), with complete control over the system, polymerization, coacervation, and dissolution. Notably, the coacervation process itself determines functional properties, as seen in selective cargo uptake. The strategy offers cutting-edge biomimetic applications, and insights into cellular compartmentalization by bridging the gap between synthetic and biological systems. The development of temporally programmed coacervation is promising for the spatial arrangement of multienzyme cascades, and offers novel ideas on the architecture of artificial cells.}, archive = {J_ANGEW}, author = {Surbhi Sharma and Andrea Belluati and Mohit Kumar and Shikha Dhiman}, doi = {10.1002/anie.202421620}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421620}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzymatic reaction network-driven polymerization-induced transient coacervation}, volume = {64}, year = {2025}, }
• (2025). Sub-5 Ångstrom porosity tuning in calixarene-derived porous liquids via supramolecular complexation construction. ANGEW, 64(11), e202421615. (www)

  @article{ , abstract = {Sub-Ångstrom-level porosity engineering, which is appealing in gas separations, has been demonstrated in solid carbon, polymer, and framework materials but rarely achieved in the liquid phase. In this work, a gas molecular sieving effect in the liquid phase at sub-5 Ångstrom scale is created via sophisticated porosity tuning in calixarene-derived porous liquids (PLs). Type II PLs are constructed via supramolecular complexation between the sodium salts of calixarene derivatives and crown ether solvents. The chemical structure variation and assembly behavior of the porous host upon PL construction are monitored by spectroscopy-, X-ray-, and neutron-scattering techniques. The presence of permanent porosity in calixarene-derived PLs is verified by pressure swing gas uptake, altered CO 2 physisorption behavior, and molecular simulations. Sub-5 Ångstrom porosity tuning within the PL phase is achieved by introducing bulky substituted groups on the benzene ring of the calixarene host, which then greatly affects the dynamic motion and transport behavior of CO 2 molecules and the Xe uptake performance. The approach being demonstrated in this work represents a promising pathway to tune and leverage the porosity effect for enhanced gas uptake capacity and selectivity in liquid sorbents.}, archive = {J_ANGEW}, author = {Errui Li and Arvind Ganesan and Hongjun Liu and Alexander S. Ivanov and Lilin He and Phattananawee Nalaoh and David M. Jenkins and Carlos Alberto Steren and Narges Mokhtari-Nori and Jianzhi Hu and Bo Li and De-en Jiang and Shannon M. Mahurin and Zhenzhen Yang and Sheng Dai}, doi = {10.1002/anie.202421615}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421615}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sub-5 Ångstrom porosity tuning in calixarene-derived porous liquids via supramolecular complexation construction}, volume = {64}, year = {2025}, }
• (2025). Propane activation on pt electrodes at room temperature: Quantification of adsorbate identity and coverage. ANGEW, 64(11), e202421613. (www)

  @article{ , abstract = {C−H bond activation is the first step in manufacturing chemical products from readily available light alkane feedstock and typically proceeds via carbon-intensive thermal processes. The ongoing emphasis on decarbonization via electrification motivates low-temperature electrochemical alternatives that could lead to sustainable chemicals production. Platinum (Pt) electrocatalysts have shown activity towards reacting alkanes; however, little is known about propane electrocatalytic activation and conditions suitable for enabling selective oxidation to valuable products. Herein, we utilize a combination of electrochemical mass spectrometry (ECMS) and density functional theory (DFT) calculations to elucidate the potential dependence of propane activation on Pt electrocatalysts. Results show a strong dependence of adsorption on the applied potential in room-temperature aqueous acidic electrolyte, with a maximum coverage of propane-derived adsorbates at 0.30 V vs RHE. Using charge deconvolution and deuterated experiments, the mechanism of adsorption was elucidated, and C 3 H 2 * was determined as the average dehydrogenated propane-derived adsorbate species. DFT calculations further corroborate these results, showing that the formation of deeply dehydrogenated species is energetically accessible at room temperature. The combined theoretical and experimental findings yield insights for selective activation of paraffinic C−H bonds at room temperature, aqueous conditions—a critical step towards decarbonized chemical manufacturing.}, archive = {J_ANGEW}, author = {Ashutosh Bhadouria and Joseph N. Heil and Durvesh E. Parab and Jeffrey P. Greeley and Brian M. Tackett}, doi = {10.1002/anie.202421613}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421613}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Propane activation on pt electrodes at room temperature: Quantification of adsorbate identity and coverage}, volume = {64}, year = {2025}, }
• (2025). Unraveling the multifunctional mechanism of fluoroethylene carbonate in enhancing high-performance room-temperature sodium-sulfur batteries. ANGEW, 64(11), e202421602. (www)

  @article{ , abstract = {Room-temperature sodium-sulfur (RT Na−S) batteries has attracted growing attentions in large-scale energy storage technology, while the serious shuttle effect and interface side reaction limit its practical application. Despite fluoroethylene carbonate (FEC) has been widely used as an electrolyte additive or co-solvent to facilitate the optimization of electrode-electrolyte interphase in RT Na−S batteries, its crucial influence and mechanism have not been clearly understood. Herein, we deeply reveal the two-steps cathode-electrolyte interphase (CEI) formation by using FEC as the exclusive electrolyte solvent. The results demonstrate that FEC participates in both rapid nucleophilic reaction and electrochemical decomposition on cathode, which can effectively in situ construct a unique “chocolate-cookie” shaped CEI consisted of NaF-rich double layers. This CEI eliminates the shuttle effect and ensures the solid-solid conversion of sulfur. Along with the stable F-rich solid-electrolyte interphase (SEI) formed on the Na anode, the RT Na−S battery delivers an impressive performance (456 mAh g −1 after 1000 cycles at 0.5 C) with almost 100 % Coulombic efficiency. This significantly simplifies electrolyte design and provides valuable insights into the application of FEC in practical Na−S batteries.}, archive = {J_ANGEW}, author = {Shixiao Weng and Yang Liu and Suwan Lu and Jingjing Xu and Jiangyan Xue and Haifeng Tu and Zhicheng Wang and Lingwang Liu and Yiwen Gao and Guochao Sun and Hong Li and Xiaodong Wu}, doi = {10.1002/anie.202421602}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the multifunctional mechanism of fluoroethylene carbonate in enhancing high-performance room-temperature sodium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Electrolyte decoupling strategy for metal oxide-based zinc-ion batteries free of crosstalk effect. ANGEW, 64(11), e202421574. (www)

  @article{ , abstract = {The crosstalk of transition metal ions between the metal oxide cathode and Zn anode restricts the practical applications of aqueous zinc-ion batteries (ZIBs). Herein, we propose a decoupled electrolyte (DCE) consisting of a nonaqueous-phase (N-phase) anolyte and an aqueous-phase (A-phase) catholyte to prevent the crosstalk of Mn 2+ , thus extending the lifespan of MnO 2 -based ZIBs. Experimental measurements and theoretical modelling verify that trimethyl phosphate (TMP) not only synergistically works with NH 4 Cl in the N-phase anolyte to enable fast Zn 2+ conduction while blocking Mn 2+ diffusion toward anode, but also modifies the Zn 2+ solvation structure to suppress the dendrite formation and corrosion on Zn anode. Meanwhile, the A-phase catholyte effectively accelerates the cathode reaction kinetics. The as-developed Zn|DCE|MnO 2 cell delivers 80.13 % capacity retention after 900 cycles at 0.5 A g −1 . This approach is applicable for other metal oxide cathode-based ZIBs, thereby opening a new avenue for developing ultrastable ZIBs.}, archive = {J_ANGEW}, author = {Mingkun Tang and Xin Zhao and Ran Han and Yao Wang and Yichen Ding and Zhichun Si and Baohua Li and Dong Zhou and Feiyu Kang}, doi = {10.1002/anie.202421574}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421574}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte decoupling strategy for metal oxide-based zinc-ion batteries free of crosstalk effect}, volume = {64}, year = {2025}, }
• (2025). Polyurethane elastomers strengthened by pseudo[1]rotaxanes based on pillararenes. ANGEW, 64(11), e202421557. (www)

  @article{ , abstract = {As a unique property of the interlocked structures, rotaxane allows for intramolecular motions between its wheel and axle components. Introduction of rotaxanes into polymers can endow them with distinctive macroscopic features and outstanding mechanical properties. Here, we prepare a copillar[5]arene with a hydroxyl and an amino-group on each end, which can spontaneously form a pseudo[1]rotaxane through intramolecular hydrogen bonds. This pseudo[1]rotaxane possesses a releasable extra alkyl chain, which is then incorporated into a linear polyurethane by reacting with a diisocyanate to prepare polyurethane elastomers with spring-like structures. The results of stress-strain test and dynamic mechanical analysis all indicate that sliding motions of the axle part on the pseudo[1]rotaxane in the polymer skeleton can greatly dissipate energy, which endows the elastomers with higher toughness and better fatigue resistance. Moreover, the addition of moderate amount of cuprous bromide to form cuprous-thioether coordination in the polymers can further improve the mechanical properties.}, archive = {J_ANGEW}, author = {Lang He and Jialin Wei and Zhiqiang Ren and Yunxia Li and Zibin Zhang and Guangfeng Li and Feihe Huang and Shijun Li}, doi = {10.1002/anie.202421557}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421557}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyurethane elastomers strengthened by pseudo[1]rotaxanes based on pillararenes}, volume = {64}, year = {2025}, }
• (2025). Diffusion/Modulator dual-mediated solid-Liquid/Vapor interfacial synthesis of crystalline covalent organic framework membranes. ANGEW, 64(11), e202421555. (www)

  @article{ , abstract = {Constructing oriented crystalline covalent organic framework (COF) membranes with controllable thickness for water purification is highly desirable. Herein, we present a simple and universal protocol to prepare high-quality COF membranes on the inner wall of a glass vessel using a diffusion/modulator dual-mediated solid–liquid/vapor interfacial synthesis strategy. By meticulous control of solvent and temperature, a thin supersaturated spreading liquid layer was formed on the glass wall surface and served as a confined microreactor for incubating crystal nuclei. This induced the aniline-modulated solid–liquid/vapor interfacial exchange reaction and upward growth of a highly ordered COF membrane. The experiments and theoretical simulations revealed the underlying mechanisms of solid–liquid/vapor interfacial nucleation, growth and crystallization. Using this strategy, we created 13 types of new, free-standing, imine-linked COF membranes with exceptional performances in crystallinity, porosity, stability, processability and adsorption capacity. As an application demonstration, a COF membrane-filled filter was coupled with high-performance liquid chromatography system for the automated removal of multitarget liquid-crystal monomers in real water samples (removal efficiency≥96 %). This study enriches the synthesis toolboxes of COF membranes and broadens their application scopes.}, archive = {J_ANGEW}, author = {Shenghuai Hou and Ganbing Zhang and Zhaoyu Qiao and Yuxuan Bai and Haoxin Di and Yetong Hua and Tiantian Hao and Hui Xu}, doi = {10.1002/anie.202421555}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421555}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diffusion/Modulator dual-mediated solid-Liquid/Vapor interfacial synthesis of crystalline covalent organic framework membranes}, volume = {64}, year = {2025}, }
• (2025). Improving the methane oxidation by self-adaptive optimization of liquid-metal catalysts. ANGEW, 64(11), e202421554. (www)

  @article{ , abstract = {Methane (CH 4 ), a major greenhouse gas and abundant carbon resource, presents significant challenges in catalysis due to its high symmetry and thermodynamic stability, which tend to cause over-oxidation to CO 2 . Traditional catalysts require high temperatures and pressures to facilitate CH 4 conversion, constrained by their rigid structures which lack the flexibility needed for optimizing complex reaction steps. This study introduces a novel Cu embedded liquid metal catalyst (Cu-LMC) based on gallium alloys, characterized by dynamic, self-adaptive structures that provide enhanced catalytic performance and selectivity. Our findings reveal that Cu-LMC achieves a high methane conversion to methanol yield (5.9 mol⋅g Cu −1 ⋅h −1 ) with a selectivity of 82 %. The results show that mild surface oxidation significantly boosts the catalytic performance of Cu-LMC by increasing active copper sites through the formation of a Cu−O−Ga configuration while preserving the catalyst‘s structural flexibility. In situ X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Fine Structure (XAFS) analyses, along with ab initio Molecular Dynamics (AIMD) simulations, demonstrate that the Cu-LMC enables self-adaptive structural adjustments that lower methanol desorption energy and increase the energy barrier for by-product formation, optimizing the overall methane conversion process. The results underscore the importance of designing catalysts with dynamic and adaptable structures to overcome traditional limitations and improve efficiency in catalytic reactions.}, archive = {J_ANGEW}, author = {Haoran Zhang and Yinhe Wang and Xiaokang Liu and Fan Wu and Xiaoqian Wang and Chunrong Ma and Xiao Han and Yihua Ran and Yan Zhang and Zhiwen Zhang and Qiang Xu and Zhandong Wang and Guozhen Zhang and Jing Wang and Jun Cai and Zhi Liu and Yu Zhang and Tao Yao and Jun Jiang and Yuen Wu}, doi = {10.1002/anie.202421554}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421554}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving the methane oxidation by self-adaptive optimization of liquid-metal catalysts}, volume = {64}, year = {2025}, }
• (2025). Towards rational design of confined catalysis in carbon nanotube by machine learning and grand canonical monte carlo simulations. ANGEW, 64(11), e202421552. (www)

  @article{ , abstract = {The microenvironment is recognized to be as crucial as active sites in heterogeneous catalysis. It was found that the catalytic activity of a set of chemical reactions can be significantly influenced by the confined space of carbon nanotubes (CNTs), with some reactions showing superior activity, while others experience a negative impact. The rational design of confined catalysis must rely on the accurate insights of confined microenvironment. However, the structural complexity of confined catalysts and the interaction with microenvironment hinders the deciphering of chemical origins behind experiments. In this work, Grand-canonical Monte Carlo (GCMC) simulations are conducted for confined catalysis in CNTs at various reaction atmospheres, accelerated by machine learning potentials. The statistical outcomes of GCMC simulations corroborate a general feature that the electronic interaction (binding energy) inside CNTs is weaker than outside cases. By using Random Forest (RF) model, we ascertain that the shortening of the bond lengths of catalysts within the confined space is the dominant factor, resulting in the weakened binding energy and the downshift of the d -band center. Using the bond length variation as a simplified descriptor, our microkinetic models successfully reproduced the seemingly contradictive experiments, namely, the observed enhancement and suppression for the same reaction.}, archive = {J_ANGEW}, author = {Chenyu Yang and Xiaoyan Fu and Dong Luan and Jianping Xiao}, doi = {10.1002/anie.202421552}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421552}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards rational design of confined catalysis in carbon nanotube by machine learning and grand canonical monte carlo simulations}, volume = {64}, year = {2025}, }
• (2025). Binder-mediated supramolecular polymerization with controllable gel-to-crystal transformation in metal-organic polyhedra. ANGEW, 64(11), e202421536. (www)

  @article{ , abstract = {Controlling supramolecular polymerization across various length scales through metal-organic polyhedra in aqueous media enables functional nanomaterial fabrication beyond traditional π-chromophoric systems. Herein, we present a straightforward strategy to tune the nano- and microscopic structural evolution of a co-assembled system. Ga-MOC ([Ga 8 (ImDC) 12 ] 12− , ImDC = imidazoledicarboxylate) is introduced as a discrete unit, while the Ni-ethylenediamine complex [Ni(en) 3 ] 2+ ( Ni-en ), served as the binder towards supramolecular polymerization. Comprehensive investigations revealed that adjusting the binder ratio in the bicomponent ( Ga-MOC and Ni-en ) co-assembly process allows precise control over nanostructure length and evolution by influencing both the kinetics and thermodynamics of the assembly. At higher concentrations, this assembly forms a hydrogel above a critical binder ratio. Furthermore, the binder′s ratio significantly influences the viscoelastic strength of the hydrogels by modulating the connectivity between the MOCs through hydrogen (H)-bonding. Intriguingly, the hydrogels gradually transformed into crystals without any external stimuli, with different timescales regulated by the binder ratio. Single crystal structure determination reveals a 3D structure composed of Ga-MOC and Ni-en , extended through charge-assisted H-bonding (CAHB) interactions, resulting through the transformation from a kinetically controlled gel state to a thermodynamically stable crystal product. This study provides an understanding of binder-mediated control over nanostructural evolution in co-assembled MOCs.}, archive = {J_ANGEW}, author = {Tarak Nath Das and Rohan Jena and Goutam Ghosh and Gustavo Fernández and Tapas Kumar Maji}, doi = {10.1002/anie.202421536}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421536}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Binder-mediated supramolecular polymerization with controllable gel-to-crystal transformation in metal-organic polyhedra}, volume = {64}, year = {2025}, }
• (2025). Conformationally stable and sterically hindered bicyclo[1.1.1]pentane-1,3-diammonium modification of FAPbI3 enhances the performance of perovskite solar cells. ANGEW, 64(11), e202421535. (www)

  @article{ , abstract = {Solution-processed α -FAPbI 3 perovskite films frequently exhibit structural defects and impurities that impede the durable operation of solar cells. In this study, we introduced a conformationally stable, sterically bulky molecular passivator, bicyclo[1.1.1]pentane-1,3-diammonium iodide (BCPDAI), by spin-coating from an isopropanol solution onto the perovskite film surface, followed by thermal annealing. This treatment effectively converted PbI 2 and δ -FAPbI 3 into a two-dimensional perovskite structure and significantly enhanced the crystal quality of α -FAPbI 3 . The BCPDAI-treated perovskite films exhibited smoother surface morphology and reduced trap densities for charge carriers, leading to improved power conversion efficiency in the solar cells. Notably, the BCPDAI-modified perovskite films provided the solar cells with enhanced operational stability. Theoretical calculations demonstrated that the high positive charge density of BCPDA 2+ confers greater binding energy at the perovskite surface and elevates the diffusion activation energy of the iodide anion.}, archive = {J_ANGEW}, author = {Ming Ren and Jing Zhang and Yaohang Cai and Lukas Pfeifer and Yanfei Mu and Yi Yuan and Min Zhang and Shaik M. Zakeeruddin and Michael Grätzel and Peng Wang}, doi = {10.1002/anie.202421535}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421535}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformationally stable and sterically hindered bicyclo[1.1.1]pentane-1,3-diammonium modification of FAPbI3 enhances the performance of perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Cooperative multiscale-assembly for directional and hierarchical growth of highly oriented porous organic cage single-crystal microtubes and arrays. ANGEW, 64(11), e202421523. (www)

  @article{ , abstract = {The directional assembly of porous organic molecules into long-range ordered architectures, featuring controlled hierarchical porosity and oriented pore channels with defined spatial arrangements, is a fundamental challenge in chemistry and materials science. Herein, using porous organic cages as starting units, we present a cooperative multiscale-assembly strategy enabling the simultaneous alignment of pore channels and directional hierarchical growth in a single step. At the microscopic level, we employed double solvents to manipulate the intermolecular packing of microporous tetrahedral [4+6] imine cages (CC1 and CC3), resulting in pore channel orientation. Concurrently, at the mesoscopic level, convective flow in the double-solvent system directed the spatial distribution of nuclei species, followed by diffusion limited growth, leading to the directional formation of single-crystal microtubes. By precisely controlling the direction of convective flow, the nanocages were successfully organized into 2D and 3D single-crystal microtube arrays while maintaining oriented micropores. This hierarchical porous architecture enhanced mass transfer, as confirmed by adsorption measurements. Interestingly, such 3D hierarchical microtube arrays can be utilized to immobilize Pd clusters and enzymes (lipase or Glucose oxidase) within the micro- and macropores, respectively, showing a 3.8- to 4-fold enhancement in one-pot tandem reaction activity compared to physical mixtures of individual analogues.}, archive = {J_ANGEW}, author = {Si-Hua Liu and Ke Zhao and Jun-Hao Zhou and Kang Dong and Hui Ai and Pai Liu and Jing-Wang Cui and Yun-Hong Zhang and Josep Puigmartí-Luis and Jian-Ke Sun}, doi = {10.1002/anie.202421523}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421523}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative multiscale-assembly for directional and hierarchical growth of highly oriented porous organic cage single-crystal microtubes and arrays}, volume = {64}, year = {2025}, }
• (2025). Discovery and total synthesis of a new class of minor immunosuppressive plant sesterterpenoids. ANGEW, 64(11), e202421497. (www)

  @article{ , abstract = {Plant sesterterpenoids are an extremely rare family of natural products that generally possess novel chemical structures and diverse biological activities. Herein, we report the discovery of an unprecedented group of minor plant sesterterpenoids, gracilisoids B−E ( 2–5 ), which feature two types of highly functionalized bicyclo[3.2.0]heptane carbon skeletons, along with their biogenetically related precursor gracilisoid A ( 1 ), from a Lamiaceae ethnomedicinal plant, Eurysolen gracilis . To confirm their structures and obtain adequate materials for biological research, the asymmetric total syntheses of gracilisoids A−E ( 1–5 ) and four new biogenetically-related congeners gracilisoids F−I ( 6–9 ) were achieved from commercially available (−)-citronellal by a bioinspired approach that involves a Norrish-Yang photocyclization/α-hydroxy ketone rearrangement tandem reaction and a late-stage biomimetic photooxidation as key steps. Biological investigations revealed that gracilisoids A−I ( 1–9 ) significantly inhibited IFN-γ production and/or T cell proliferation probably through inhibition of the STAT pathway. The findings herald the potential of these gracilisoids as novel immunosuppressive agents, and efficient synthetic approaches will facilitate a comprehensive evaluation of their value in future drug development.}, archive = {J_ANGEW}, author = {Yu Zheng and Lin-Lin Teng and Ting-Ting Zhou and Zhi-Wei Liu and Kai Guo and Hao Li and Tao Li and Liang-Liang Wang and Yan Liu and Sheng-Hong Li}, doi = {10.1002/anie.202421497}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421497}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Discovery and total synthesis of a new class of minor immunosuppressive plant sesterterpenoids}, volume = {64}, year = {2025}, }
• (2025). Quantitative formation of octa-substituted cyclobutanes by the [2+2] photocycloaddition of stiff-stilbenes. ANGEW, 64(11), e202421472. (www)

  @article{ , abstract = {The creation of new molecules with specific structural motifs is a primary goal in synthetic chemistry. In this context, cyclobutanes (CBs), the highly strained ring systems, are of great interest because of their wide applications from pharmaceutical chemistry to materials science. The [2+2] photocycloaddition is the most straightforward approach for CBs; however, access to fully substituted cyclobutanes presents a significant challenge due to the steric hindrance imposed by eight substituents. Here, we report an efficient synthesis of structurally unique, octa-substituted cyclobutanes from stiff-stilbene precursors, which is enabled by adaptable anion coordination through hydrogen bonding networks. The synthesized spiro-benzocyclopentyl-substituted cyclobutanes are confirmed by single-crystal structures. DFT calculations indicate that these cyclobutanes have high ring-strain energies (~20.1 kcal/mol) and can be completely converted back to stiff-stilbenes. Such a reversible cycloaddition/reversion process offers a promising platform for applications in responsive and energy storage materials.}, archive = {J_ANGEW}, author = {Xiao-Wen Sun and Yu Li and Mengxue Lu and Wei Zhao and Hongwei Ma and Xiao-Juan Yang and Biao Wu}, doi = {10.1002/anie.202421472}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantitative formation of octa-substituted cyclobutanes by the [2+2] photocycloaddition of stiff-stilbenes}, volume = {64}, year = {2025}, }
• (2025). Visible light-mediated [4+2] annulation of silylimines with olefins to 1-aminotetralins enabled by diradical hydrogen atom transfer of C−H bonds. ANGEW, 64(11), e202421464. (www)

  @article{ , abstract = {A facile photochemical, one-pot synthesis of highly functionalized 1-aminotetralins derivatives (>70 examples) from readily accessible o -alkyl and o -formyl aryl silylimines with olefins is described. A diradical-mediated hydrogen atom transfer (DHAT) of primary, secondary, and tertiary C(sp 3 )−H bonds of o -alkyl arylsilylimines and C(sp 2 )−H bonds of o -formyl arylsilylimines enabled a [4+2] annulation with olefins in excellent diastereoselectivity. This was accomplished upon irradiation at λ = 420 nm in the presence of thioxanthen-9-one (10 mol %) as the sensitizer via energy transfer. Moreover, sulfur-substituted o -alkyl silylimines can undergo such photochemical process in the absence of an external photosensitizer. This effective protocol is compatible with a variety of functional groups and can be applied to the modification of bioactive molecules. Based on mechanistic evidences and computational studies, it is suggested that the silyl substituent enables an efficient energy transfer leading to the formation of a key C,N-diradical and subsequent [4+2]-cyclization was supported by a better molecular orbital matching between the HSOMO of the 1,4-diradical intermediate and the LUMO of the olefins. Thus, upon irradiation, the excited silylimine unlocks a carbon-to-nitrogen DHAT and subsequent [4+2] cyclization that allows the divergent functionalization of benzylic C(sp 3 )−H bonds and C(sp 2 )−H bonds.}, archive = {J_ANGEW}, author = {Qian Liu and Yao Huang and Xiang Zhou and Israel Fernández and Yang Xiong}, doi = {10.1002/anie.202421464}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421464}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible light-mediated [4+2] annulation of silylimines with olefins to 1-aminotetralins enabled by diradical hydrogen atom transfer of C−H bonds}, volume = {64}, year = {2025}, }
• (2025). Ring-in-ring assembly facilitates the synthesis of a [12]Cycloparaphenylene ABC-type [3]Catenane. ANGEW, 64(11), e202421459. (www)

  @article{ , abstract = {Cycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem and explore the fundamental and functional properties of CPP rotaxanes and catenanes, researchers have resorted to unusual non-covalent and even to labor-intensive covalent template approaches. Herein, we report a ring-in-ring non-covalent template strategy that makes use of the surprisingly strong non-covalent inclusion of crown ethers into suitably sized CPPs. By threading a secondary ammonium salt through the crown ether and closing the third ring via CuAAC click reaction, we obtained a rare ABC-type hetero-[3]catenane comprising [12]CPP, 24-crown-8 and a dibenzylammonium macrocycle. X-ray crystallography shed light on the ring-in-ring pre-organization and the [3]catenane topology was confirmed by NMR and MS-MS studies. Molecular simulations provided insights into the intriguing ring- vs .-ring- vs .-ring dynamics of the [3]catenane, which are highly dependent on the protonation state of the dibenzylammonium site. This ring-in-ring assembly strategy opens new avenues for the synthesis of complex CPP architectures and their use in functional supramolecular systems.}, archive = {J_ANGEW}, author = {Wudi Shi and Yaning Hu and Luigi Leanza and Yevhenii Shchukin and Patrick A. Hoffmann and Meng-Hua Li and Chengbing Ning and Zhong-Yan Cao and Yuan-Qing Xu and Pingwu Du and Max von Delius and Giovanni M. Pavan and Youzhi Xu}, doi = {10.1002/anie.202421459}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ring-in-ring assembly facilitates the synthesis of a [12]Cycloparaphenylene ABC-type [3]Catenane}, volume = {64}, year = {2025}, }
• (2025). Two-level spatially localized proximity labeling for cross-biological-hierarchy measurement and manipulation. ANGEW, 64(11), e202421448. (www)

  @article{ , abstract = {Proximity labeling (PL) has emerged as a powerful technique for the in situ elucidation of biomolecular interaction networks. However, PL methods generally rely on single-biological-hierarchy control of spatial localization at the labeling site, which limits their application in multi-tiered biological systems. Here, we introduced another enzymatic reaction upstream of an enzyme-based PL reaction and targeted the two enzymes to markers indicating different biological hierarchies, establishing a two-level spatially localized proximity labeling (P 2 L) platform for in situ molecular measurement and manipulation. Using the cellular- and glycan-level as the hierarchical models, we demonstrated the ability of P 2 L to efficiently execute a two-step logic operation and to discriminate target cells with different levels of glycosylation within mixed cell populations. By mounting clickable handles via P 2 L, we reprogrammed the robust covalent assembly of cells at designated sites. The combination of P 2 L with proteomics led to the profiling of the protein microenvironment of specific glycans on target cells, revealing changes in tumor-cell-surface interactions under immune pressure from a glycan perspective. P 2 L provides not only a solution for revealing the heterogeneity of biological systems, but also new insights in the fields of intelligent logic computation, enzyme engineering, tissue engineering, etc.}, archive = {J_ANGEW}, author = {Liusheng Chen and Yiran Li and Yuna Guo and Guyu Wang and Nan Feng and Jiahui Sun and Yihong Zhong and Yunyan Yao and Lin Ding and Huangxian Ju}, doi = {10.1002/anie.202421448}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421448}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-level spatially localized proximity labeling for cross-biological-hierarchy measurement and manipulation}, volume = {64}, year = {2025}, }
• (2025). Elemental germanium activation and catalysis enabled by mechanical force. ANGEW, 64(11), e202421446. (www)

  @article{ , abstract = {In the realm of materials science and chemical industry, germanium emerges as a strategic resource with distinctive properties that extend its applicability beyond traditional electronics and optics into the promising field of chemical catalysis. Despite its significant role in advanced technological applications, the potential of elemental germanium as a catalyst remains unexplored. Leveraging recent developments in mechanochemistry, this study introduces a groundbreaking approach to activate elemental germanium via mechanical force, facilitating the Reformatsky reaction without the reliance on external reducing agents. Meanwhile, we have also demonstrated, for the first time, the catalytic activity of elemental germanium, successfully achieving this through the bromoalkylation of alkenes. These achievements mark a significant advancement in the field of catalysis and open up a new promising avenue for both academic research and industrial applications.}, archive = {J_ANGEW}, author = {Guangqing Guo and Jie Zhou and Xiaochun He and Na Li and Nan Lin and Xuemei Zhang and Zhong Lian}, doi = {10.1002/anie.202421446}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421446}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elemental germanium activation and catalysis enabled by mechanical force}, volume = {64}, year = {2025}, }
• (2025). Selection of plastic-binding DNA aptamers for microplastics detection. ANGEW, 64(11), e202421438. (www)

  @article{ , abstract = {Plastics are critical materials for modern technological applications, yet environmental contamination by microplastics has become a growing concern. In this study, DNA aptamers were isolated for two of the most abundant plastic materials: polyvinylchloride (PVC) and polystyrene (PS). These aptamers contain approximately 90 % cytosine and thymine but only 10 % purine content. Among them, the PVC-1 aptamer binds to PVC with a six-fold higher capacity than a random sequenced DNA. Among the tested plastic materials, PVC and PS exhibited the highest specific binding capacity. Using fluorophore-labeled PVC-1 aptamer, PS/PVC microplastics as low as 1 mg were detected, and the aptamer was selective for microplastics over other environmentally relevant materials, such as silica. Molecular dynamics simulations indicated that the aptamer attempted to maximize contact with the plastic surface for adsorption. This plastic-binding aptamer is expected to find applications in environmental monitoring and has fundamental implications for surface-binding aptamers.}, archive = {J_ANGEW}, author = {Mohamad Zandieh and Xin Luo and Yu Zhao and Chuanliang Feng and Juewen Liu}, doi = {10.1002/anie.202421438}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421438}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selection of plastic-binding DNA aptamers for microplastics detection}, volume = {64}, year = {2025}, }
• (2025). Multiscale engineered bionic solid-state electrolytes breaking the stiffness-damping trade-off. ANGEW, 64(11), e202421427. (www)

  @article{ , abstract = {All-solid-state lithium metal batteries (LMBs) are regarded as next-generation devices for energy storage due to their safety and high energy density. The issues of Li dendrites and poor mechanical compatibility with electrodes present the need for developing solid-state electrolytes with high stiffness and damping, but it is a contradictory relationship. Here, inspired by the superstructure of tooth enamel, we develop a composite solid-state electrolyte composed of amorphous ceramic nanotube arrays intertwined with solid polymer electrolytes. This bionic electrolyte exhibits both high stiffness (Young′s modulus=15 GPa, hardness=0.13 GPa) and damping (tan δ =0.08), breaking the trade-off. Thus, this composite electrolyte can not only inhibit Li dendrites growth but also ensure intimate contact with electrodes. Meanwhile, it also exhibits considerable Li + transference number (0.62) and room temperature ionic conductivity (1.34×10 −4 S cm −1 ), which is attributed to oxygen vacancies of the amorphous ceramic effectively decoupling the Li-TFSI ion pair. Consequently, the assembled Li symmetric battery shows an ultra-stable cycling (>2000 hours at 0.1 mA cm −2 at 60 °C, >500 hours at 0.1 mA cm −2 at 30 °C). Moreover, the LiFePO 4 /Li and LiNi 0.8 Co 0.1 Mn 0.1 O 2 /Li all-solid-state full cells both show excellent cycling performance. We demonstrate that this bionic strategy is a promising approach for the development of high-performance solid-state electrolytes.}, archive = {J_ANGEW}, author = {Junyu Hou and Wu Sun and Qunyao Yuan and Longjiang Ding and Yanhua Wan and Zuohui Xiao and Tianke Zhu and Xingyu Lei and Jingsen Lin and Rongrong Cheacharoen and Yunlei Zhou and Shaolei Wang and Farid Manshaii and Jin Xie and Wei Li and Jie Zhao}, doi = {10.1002/anie.202421427}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421427}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiscale engineered bionic solid-state electrolytes breaking the stiffness-damping trade-off}, volume = {64}, year = {2025}, }
• (2025). Amino-acid-induced circularly polarized luminescence of octahedral lanthanide cage. ANGEW, 64(11), e202421426. (www)

  @article{ , abstract = {Chiral metal organic cage compounds with excellent circularly polarized luminescent performance have broad application prospects in many fields. Herein, two lanthanide complexes with luminescent properties in the form of racemic hexagonal octahedral cages were synthesized using a tri ( β- diketone) ligand. Eu 6 (C 21 H 6 F 15 O 6 ) 8 (H 2 O) 6 exhibited red light emission with high quantum yields of 61 %. Then, we successfully synthesized lanthanide compounds with circularly polarized luminescent activity by chiral induction of the racemic mixture with arginine. The luminescence asymmetry factor was 0.53, and the circularly polarized luminescent merit figure reached 0.323. High-performance circularly polarized luminescent of racemic cage like compound systems have achieved using cheap and readily available chiral amino acid molecules through chiral induction.}, archive = {J_ANGEW}, author = {Teng Zhao and Yu-Fei Zhang and Guang-Hao Wang and Xuan-Xuan Wang and Peng-Fei Feng and Shuang-Quan Zang}, doi = {10.1002/anie.202421426}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amino-acid-induced circularly polarized luminescence of octahedral lanthanide cage}, volume = {64}, year = {2025}, }
• (2025). Adjusting TADF and phosphorescence for tailored dynamic time-dependent afterglow colored carbon dots spanning full visible region. ANGEW, 64(11), e202421421. (www)

  @article{ , abstract = {Time-dependent afterglow colored (TDAC) behavior differs from static afterglow by involving wavelength changes, enabling low-cost, high-level encryption and anti-counterfeiting. However, the existing carbon dot (CD)-based TDAC materials lack a clear mechanistic explanation and controllable wavelength changes, significantly hindering the progress of practical applications in this field. In this study, we synthesized CDs composites with customizable tunable TDAC wavelengths across the visible region. Furthermore, we elucidated the underlying mechanism of TDAC that exhibits sequential weakening and relative strengthening of long- and short-wavelength afterglow centers. This phenomenon arises due to strong emission with a short lifetime originating from long-wavelength thermally activated delayed fluorescence (TADF), along with weak emission having a longer lifetime originating from short-wavelength phosphorescence. The presence of surface-rich carboxyl groups on CDs determines the short-wavelength afterglow in their dispersed state while their high conjugation degree governs the long-wavelength afterglow in their aggregated state. Additionally, appropriate doping levels of CDs enhance color change phenomena during afterglow. Finally, by embedding CDs into different rigid matrix, the range of afterglow changes can be tailored arbitrarily within the visible light region. Leveraging these exceptional TDAC characteristics has allowed us to successfully develop advanced 4D coding technologies that facilitate multi-mode anti-counterfeiting and dynamic information encryption.}, archive = {J_ANGEW}, author = {Yongqiang Zhang and Yue Liu and Xueyan Ren and Yihong Kang and Shurong Ding and Siyu Lu}, doi = {10.1002/anie.202421421}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421421}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Adjusting TADF and phosphorescence for tailored dynamic time-dependent afterglow colored carbon dots spanning full visible region}, volume = {64}, year = {2025}, }
• (2025). Construction of axially chiral dialdehydes via rhodium-catalyzed enantioselective C−H amidation. ANGEW, 64(11), e202421412. (www)

  @article{ , abstract = {Achieving axially chiral biaryl dialdehydes through asymmetric catalysis remains significantly challenging due to the lack of efficient strategies. In this report, we developed a rhodium-catalyzed enantioselective C−H amidation through chiral transient directing group strategy. With this new approach, a series of axially chiral amido dialdehydes were achieved in up to 86 % yields with 99.5 : 0.5 er. Furthermore, detailed mechanistic studies indicated that both the imine formation and C−H bond cleavage steps were reversible. More interestingly, the X-ray crystallographic analysis of Int-2 showed probable C−H/π interaction between biaryl group and chiral amine moiety. This process offered a convenient route to access axially chiral dialdehyde derivatives. More broadly, it demonstrated a new tool through transient and C−H/π synergistic interactions, which would stimulate further development of asymmetric catalytic system in enantioselective C−H functionalization.}, archive = {J_ANGEW}, author = {Jie-Ying Yang and Ya-Ru Du and Fu-Qiang Cheng and Kun An and Yuefei Hu and Zhong-Yuan Li}, doi = {10.1002/anie.202421412}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421412}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of axially chiral dialdehydes via rhodium-catalyzed enantioselective C−H amidation}, volume = {64}, year = {2025}, }
• (2025). Counterions determine if metal-organic cages convert SO2 to sulfate or reversibly adsorb it. ANGEW, 64(11), e202421169. (www)

  @article{ , abstract = {The continuous emission of harmful gases into the atmosphere damages the environment, air quality, and public health worldwide. To mitigate their impact, materials that capture and chemically inactivate gases are required; however, integrating and precisely controlling both abilities within a single material remains challenging. Herein, we demonstrate for the first time that switching between SO 2 -physisorption and chemisorption is possible for porous materials by using different counterions, as illustrated with a series of Pd 6 L 8 Metal-Organic Cages (MOCs). Pd-MOCs bearing BF 4 − , PF 6 − , or SO 4 2− expressed reversible adsorption (up to 3.6 mmol g −1 ), cyclability, and SO 2 /CO 2 selectivity. NO 3 − promoted conversion of SO 2 to sulfate, as corroborated with M 6 L 8 cages built on Co(II), Cu(II), and Zn(II) ions. Noteworthy, the nitrate derivative of Pd 6 L 8 captures 6.0 mmol g −1 of SO 2 , cleanly transforms it to SO 4 2− within its cavity in 94 % yield at room temperature, it is quantitatively regenerated, and tolerates humid SO 2 ; such qualities are unprecedented for SO 2 adsorbents. The deliberate use of counterions for modulating adsorption could be applied to charged MOFs, COFs, or POCs, potentially leading to the development of new reactivity or catalysis pathways for advanced applications against contaminant gases.}, archive = {J_ANGEW}, author = {Edmundo G. Percástegui and Elí Sánchez-González and Sergio de Jesús Valencia-Loza and Sofía Cruz-Nava and Vojtech Jancik and Diego Martínez-Otero}, doi = {10.1002/anie.202421169}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Counterions determine if metal-organic cages convert SO2 to sulfate or reversibly adsorb it}, volume = {64}, year = {2025}, }
• (2025). Desymmetrization of 1,4-diynes by allylic alcohol-triggered redox enyne cycloisomerization. ANGEW, 64(11), e202421153. (www)

  @article{ , abstract = {We report herein an unprecedented desymmetrization of 1,4-diynes via a Rh-catalyzed asymmetric redox cycloisomerization. This method adopts allylic alcohol-containing diynes and provides efficient access to multi-functional pyrrolidines and tetrahydrofurans in high to excellent stereoselectivities. Mechanistic studies highlighted an innovative catalytic pathway that differs from the classical enyne cycloisomerization and involves initiation at the allylic alcohol moiety. Diverse derivatizations of the heterocyclic products including intriguing skeletal rearrangements have also been demonstrated.}, archive = {J_ANGEW}, author = {Fangyuan Wang and Wenxuan Lin and Chia Hui Yeh and Yu Lan and Yu Zhao}, doi = {10.1002/anie.202421153}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421153}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Desymmetrization of 1,4-diynes by allylic alcohol-triggered redox enyne cycloisomerization}, volume = {64}, year = {2025}, }
• (2025). Spatially preorganized hybridization chain reaction for the prompt diagnosis of inflammation. ANGEW, 64(11), e202421022. (www)

  @article{ , abstract = {Biological systems utilize precise spatial organization to facilitate and regulate information transmission within signaling networks. Inspired by this, artificial scaffolds that enable delicate spatial arrangements are desirable to increase the local concentration of reactants, expedite specific interactions, and minimize undesired interference. In this study, we presented an integrated biosensing nanodevice, termed TRI-HCR, in which hybridization chain reaction (HCR) probes were precisely organized on a triangular DNA origami nanostructure (TRI) with finely-tuned distance, quantity, and pattern. Compared to traditional HCR in the free form, this nanodevice demonstrated increased reaction rate and signal level. We further employed the optimized TRI-HCR for in vivo imaging of a nucleic acid biomarker of inflammatory diseases. In both acute gouty arthritis (AGA) and sepsis-associated acute kidney injury (SA-AKI) model mice, TRI-HCR was capable of diagnosing inflammation in the early stages, significantly earlier than histological examination. We anticipate that this precise spatial preorganization strategy for HCR holds promise for broader applications in early disease detection and monitoring.}, archive = {J_ANGEW}, author = {Bin Jia and Jingru Ge and Yuxuan Ma and Xiaolei Sun and Zhe Li and Shuoxing Jiang and Hanyang Yu}, doi = {10.1002/anie.202421022}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202421022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatially preorganized hybridization chain reaction for the prompt diagnosis of inflammation}, volume = {64}, year = {2025}, }
• (2025). Stereoselective preparation and palladium-catalyzed Suzuki–Miyaura cross-coupling of alkenyl sulfoximines. ANGEW, 64(11), e202420949. (www)

  @article{ , abstract = {Although numerous transition-metal catalyzed cross-coupling reactions of alkenyl electrophiles with a sulfur(VI) leaving group, mainly alkenyl sulfones, have been developed, most rely heavily on highly nucleophilic Grignard reagents, and the use of organoboron reagents remains challenging. We report herein facile preparation and the following Pd-catalyzed Suzuki–Miyaura cross-coupling reaction of alkenyl sulfoximine, a monoaza analog of sulfone. The condensation of alkyl sulfoximine with aldehydes, developed in this study, makes alkenyl sulfoximines more readily available. The resulting alkenes undergo an unprecedented oxidative addition of the C−S bond to the Pd center. This cross-coupling proceeds with retention of its original stereochemistry and provided alkenes bearing three different functionalities in a stereoselective fashion. DFT calculations highlight the critical role of boronic acid and in situ -generated boroxines in facilitating this transformation.}, archive = {J_ANGEW}, author = {Kosuke Yasui and Yuichiro Tomishima and Tomoya Miura and Ken Yamazaki and Koji Hirano}, doi = {10.1002/anie.202420949}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202420949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereoselective preparation and palladium-catalyzed Suzuki–Miyaura cross-coupling of alkenyl sulfoximines}, volume = {64}, year = {2025}, }
• (2025). Accessing a carboxyl-anhydride molecular switch-mediated recyclable PECT through upcycling end-of-use PET. ANGEW, 64(11), e202420839. (www)

  @article{ , abstract = {Poly(ethylene terephthalate) (PET), with an annual production of exceeding 70 million tons, is mainly utilized in disposable fields and subsequently contribute to severe environmental pollution. Conventional chemical recycling, which typically involves depolymerizing polymer into monomers, is limited due to the intricate recycling process, excess using unrecyclable solvents and low polymer conversion. Inspired by protein's molecular switches, we propose a novel polymer-to-polymer recycling strategy based on polycondensation principles upcycling waste PET to high-value recyclable poly(ethylene- co -1,4-cyclohexanedimethanol terephthalate) derivatives containing molecular switches. Upon deactivating the molecular switch, an acidification reaction occurs within the system, leading to a rapid and controllable reduction in molecular weight due to the imbalance of reactive group. Conversely, activating the molecular switch triggers a ring-closing reaction that detaches acid anhydrides, bringing about equal molar ratio of groups and thereby facilitating an increase in molecular weight. By simply incorporating a molecular switch into condensation products based on melt polycondensation, closed-loop recycling capability is achieved without necessitating excessive organic solvents or complex depolymerization processes. The present study not only presents a novel pathway for end-of-use PET upcycling but also introduces an innovative concept of molecular switching for the closed-loop recyclability of condensation polymers, thereby demonstrating significant potential for large-scale implementation.}, archive = {J_ANGEW}, author = {Hongjie Zhang and Mingyuan Fang and Shihao Niu and Miaomiao Wang and Mingyu Gao and Qiuquan Cai and Gangqiang Wang and Wenxing Chen and Wangyang Lu}, doi = {10.1002/anie.202420839}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202420839}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accessing a carboxyl-anhydride molecular switch-mediated recyclable PECT through upcycling end-of-use PET}, volume = {64}, year = {2025}, }
• (2025). Co-feeding CO2 for methylfuran aromatization over bifunctional zeolite-supported ZnMoO4. ANGEW, 64(11), e202420779. (www)

  @article{ , abstract = {Aromatization of biofuran offers promising approaches for sustainable biochemical production. However, this process is often hampered by low yields and severe coking on traditional zeolite catalysts. Herein, we report co-feeding CO 2 for 2-methylfuran (MF) aromatization (CCMA) over bifunctional ZSM-5 supported ZnMoO 4 . This bifunctional catalyst can achieve both MF and CO 2 conversions of >97 %, generating >85 % carbon yield of target arenes and CO with negligible alkenes (0.05 %). Meanwhile, coke formation is remarkably suppressed from 22.3 % to 8.6 %. ZnMoO 4 /ZSM-5 is capable of selectively manipulating the reaction intermediates and pathways of the CCMA reactions, favoring the cyclopentenones- and alkenes-based dehydro-aromatization rather than the benzofurans-based pathway. This finding challenges the prevailing understanding that MF aromatization follows a hydrocarbon pool mechanism. Moreover, the abundant surface oxygen vacancies of ZnMoO 4 facilitate the adsorption of CO 2 and its subsequent reaction with coke. These insights into reaction mechanism and catalyst design for co-conversion of CO 2 and biofuran can offer guidelines for process intensification in biomass utilization with a carbon-negative manner.}, archive = {J_ANGEW}, author = {Shengpeng Xia and Kun Zhao and Yunfei Gao and Yuyang Fan and Chenyang Wang and Tongpo Yu and Hong Wang and Jinyang Zhang and Zhandong Wang and Xing Zhu and Zengli Zhao and Anqing Zheng}, doi = {10.1002/anie.202420779}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202420779}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Co-feeding CO2 for methylfuran aromatization over bifunctional zeolite-supported ZnMoO4}, volume = {64}, year = {2025}, }
• (2025). Orthogonal-group-controlled site-selective I-branching of poly-N-acetyllactosamine chains reveals unique binding specificities of proteins towards I-antigens. ANGEW, 64(11), e202420676. (www)

  @article{ , abstract = {Poly- N -acetyllactosamine (poly-LacNAc) is ubiquitously expressed on cell surface glycoconjugates, serving as the backbone of complex glycans and an extended scaffold that presents diverse glycan epitopes. The branching of poly-LacNAc, where internal galactose (Gal) residues have β1-6 linked N -acetylglucosamine (GlcNAc) attached, forms the blood group I-antigen, which is closely associated with various physiological and pathological processes including cancer progression. However, the underlying mechanisms remain unclear as many of the I-antigen sequences are undefined and inaccessible. In this study, we developed a highly efficient orthogonal-group-controlled approach to access site-selectively I-branched poly-LacNAc chains. The approach relies on three orthogonal protecting groups, each of them “caps” one internal Gal residue of poly-LacNAc. These groups can be readily “decapped” by specific enzymes or chemical reduction to expose desired sites for GCNT2-catalyzed I-branching. This approach enabled the rapid preparation of a diverse library of 41 linear and branched poly-LacNAc glycans from a single precursor. Glycan microarray analysis using these complex glycans revealed unique recognitions of I-branches by lectins, anti-I mAbs, and galectins. Surprisingly, oxidized forms of linear poly-LacNAc strongly bound to several glycan-binding proteins (GBPs). These findings help to bridge the gap in recognition of I-branching and open new avenues for therapeutic development by targeting galectins.}, archive = {J_ANGEW}, author = {Shumin Bao and Tangliang Shen and Congcong Chen and Jinghua Han and Virginia Tajadura-Ortega and MohammadHossein Shabahang and Zhenming Du and Ten Feizi and Wengang Chai and Lei Li}, doi = {10.1002/anie.202420676}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202420676}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orthogonal-group-controlled site-selective I-branching of poly-N-acetyllactosamine chains reveals unique binding specificities of proteins towards I-antigens}, volume = {64}, year = {2025}, }
• (2025). Glucuronidase-instructed glycopeptide self-assembly for selective killing of cancer cells through lysosomal membrane permeabilization. ANGEW, 64(11), e202420596. (www)

  @article{ , abstract = {Current cancer treatments face significant challenges, including limited tumor specificity and drug resistance. Enzyme-instructed supramolecular peptide assembly targeting lysosomes offers a promising strategy to address these issues; however, self-assembling units that withstand lysosomal conditions are still scarce. Herein, we present a versatile glycopeptide incorporating glucuronic acid and glucose that undergoes glucuronidase-triggered self-assembly to form nanofibers, leading to lysosomal membrane permeabilization (LMP) in cancer cells. Mechanistic studies revealed that in glucuronidase-overexpressing HepG2 cells, glycopeptide assembly induces cytoskeletal disruption and apoptosis. The involvement of carbohydrate-binding receptor in enhancing the cellular entry of glycopeptides and improving proteolytic stability highlights the importance of glycan modification. Notably, combining this glycopeptide with cisplatin or Adriamycin results in synergistic cytotoxicity, including in drug-resistant cancer cell lines. These findings establish a novel, LMP-inducing glycopeptide scaffold for developing targeted approaches for cancer treatment.}, archive = {J_ANGEW}, author = {Zhongxin Xu and Changdong He and Xinyu Li and Lu Huang and Bo Cheng and Suwei Dong}, doi = {10.1002/anie.202420596}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202420596}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Glucuronidase-instructed glycopeptide self-assembly for selective killing of cancer cells through lysosomal membrane permeabilization}, volume = {64}, year = {2025}, }
• (2025). Excited-state and steric hindrances engineering enable fast spin-flip narrowband thermally activated delayed fluorescence emitters with enhanced quenching resistance. ANGEW, 64(11), e202420489. (www)

  @article{ , abstract = {Multi-resonance thermally activated delayed fluorescence (MR-TADF) materials have great potential for applications in ultrahigh-definition (UHD) organic light-emitting diode (OLED) displays, that benefit from their narrowband emission characteristic. However, key challenges such as aggregation-caused quenching (ACQ) effect and slow triplet-to-singlet spin-flip process, especially for blue MR-TADF materials, continue to impede their development due to planar skeletons and relatively large Δ E ST s. Here, an effective strategy that incorporates multiple carbazole donors into the parent MR moieties is proposed, synergistically engineering their excited states and steric hindrances to enhance both the spin-flip process and quenching resistance. As expected, the designed materials namely 5Cz-BNO and 5Cz-BN exhibit bright blue and green emissions with narrow full-width at half-maximums (FWHMs) around 23 nm, together with significantly improved reverse intersystem crossing (RISC) rates. The OLEDs based on 5Cz-BNO and 5Cz-BN with doping concentrations from 5 to 20 wt % achieve high maximum external quantum efficiency (EQE max ) values exceeding 30 % with suppressed efficiency roll-offs and improved operational stability. This work offers an effective approach for designing doping-insensitive blue and green MR-TADF materials with fast spin-flip processes by integrating the engineering of excited states and steric hindrances.}, archive = {J_ANGEW}, author = {Rui-Zhi An and Fang-Ming Zhao and Changjiao Shang and Meng Zhou and Lin-Song Cui}, doi = {10.1002/anie.202420489}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202420489}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Excited-state and steric hindrances engineering enable fast spin-flip narrowband thermally activated delayed fluorescence emitters with enhanced quenching resistance}, volume = {64}, year = {2025}, }
• (2025). Revealing the potential of a chimaera: A peptide-peptide nucleic acid molecule designed to interact with the SARS-CoV-2 nucleocapsid protein. ANGEW, 64(11), e202420134. (www)

  @article{ , abstract = {Numerous RNA-binding proteins have modular structures with folded domains and intrinsically disordered regions, making their atomic characterization difficult. This severely limits the investigation of their modalities of interaction as well as the evaluation of possible ways to interfere with this process. We report herein a rational strategy for the design and synthesis of a ligand able to interfere with the protein function, monitoring the interaction through solution nuclear magnetic resonance spectroscopy. Our approach employs a chimaera composed of two different fragments, a peptide and a peptide-nucleic acid, allowing to incorporate in the resulting molecule key features to address RNA-protein interactions. Focusing on two constructs of the Nucleocapsid protein from SARS-CoV-2, the globular N-terminal domain and a more extended one comprising also two flanking intrinsically disordered regions, we demonstrate the enhanced affinity of the designed peptide-peptide nucleic acid chimaera for the protein compared to a related peptide lacking π–π stacking contributions within the chain. Furthermore, we emphasize the increasingly recognized relevant and synergistic role of the intrinsically disordered regions in protein-ligand interaction.}, archive = {J_ANGEW}, author = {Angela Sofia Tino and Michael Quagliata and Marco Schiavina and Lorenzo Pacini and Anna Maria Papini and Isabella C. Felli and Roberta Pierattelli}, doi = {10.1002/anie.202420134}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202420134}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing the potential of a chimaera: A peptide-peptide nucleic acid molecule designed to interact with the SARS-CoV-2 nucleocapsid protein}, volume = {64}, year = {2025}, }
• (2025). Enhanced electroluminescence and stability of sky-blue perovskite light-emitting diodes. ANGEW, 64(11), e202419746. (www)

  @article{ , abstract = {Although remarkable breakthroughs have been witnessed in the field of perovskite light-emitting diodes (PeLEDs), achieving efficient and stable blue PeLEDs still remains as a critical challenge to towards commercial applications. Inspired by the protection effect and water-repellent properties of swan feathers, 2H,2H,3H,3H-heptadecafluoroundecanoic acid (HFUA) has been designed as adsorbed functional molecule for blue perovskites, which can simultaneously enhance the electroluminescence performance and moisture stability. The HFUA molecule features a long-chain structure where the carboxylic acid group acts as an anchor, coordinating with undercoordinated lead atoms in blue perovskites. The fluorine atoms at the opposite end of the chain form ionic bonds with the halogen octahedron, thereby stabilizing the octahedral structure. In addition, HFUA adsorption lowers the adsorption energy of organic spacers on the perovskite lattice, optimizing the reduced-dimensional phase distribution to facilitate smooth exciton transfer. Furthermore, the unique molecular structure of HFUA, rich in fluorine atoms, enhances the hydrophobicity of the perovskite surface, effectively inhibiting moisture penetration and preventing perovskite hydrolysis. The target blue PeLEDs obtain a maximum external quantum efficiency of 22.88 % at 490 nm and exhibit greatly improved air stability under humid and high-temperature conditions. Our findings provide a unique and effective strategy for producing efficient and stable blue PeLEDs.}, archive = {J_ANGEW}, author = {Bing-Feng Wang and Yi Yu and Yang Shen and Yuan-Hang Wu and Zhen-Huang Su and Yu-Tong Wang and Yu-Hang Zhang and Long-Xue Cao and Xing-Yu Gao and Jian-Xin Tang and Yan-Qing Li}, doi = {10.1002/anie.202419746}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202419746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced electroluminescence and stability of sky-blue perovskite light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Degradable adhesives as sustainable alternatives to acrylics via ring-opening radical polymerization of vinylcyclopropanes. ANGEW, 64(11), e202419498. (www)

  @article{ , abstract = {Acrylic pressure-sensitive adhesives (PSAs) are loosely crosslinked polymer networks widely used across various industries. However, the network structure and inert nature of the acrylic polymer backbone present sustainability challenges. To address these issues, efforts are being made to incorporate degradable units into the polymer backbone. Yet, two key obstacles remain: i) the polymer does not degrade into sufficiently small fragments, and ii) the adhesive and viscoelastic properties are often inferior to those of conventional acrylic polymers. In this study, we developed a PSA utilizing vinylcyclopropane (VCP)-based monomers and a VCP-based crosslinker, achieving molecular-level degradation while maintaining adhesive performance and viscoelastic properties comparable to traditional acrylic PSAs. Under optimized polymerization conditions, the polymer incorporates ozone-labile double bonds into its backbone, enabling controlled molecular degradation without compromising its properties. By synthesizing and strategically combining various VCP-based monomers, we developed PSAs with tailored adhesion and viscoelastic behavior on par with conventional acrylic PSAs. These advancements indicate that the degradable polymers and PSAs developed in this study are poised for practical application in the near future.}, archive = {J_ANGEW}, author = {Daewhan Kim and Changhoon Yu and Min Sang Kwon}, doi = {10.1002/anie.202419498}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202419498}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Degradable adhesives as sustainable alternatives to acrylics via ring-opening radical polymerization of vinylcyclopropanes}, volume = {64}, year = {2025}, }
• (2025). Monodisperse chemical oligophosphorylation of peptides via protected oligophosphorimidazolide reagents. ANGEW, 64(11), e202419147. (www)

  @article{ , abstract = {Protein poly- and oligophosphorylation are recently discovered post-translational modifications that remain poorly characterized due to (1) the difficulty of extracting endogenously polyphosphorylated species without degradation and (2) the absence of synthetic and analytical tools to prepare and characterize poly- and oligophosphorylated species in biochemical contexts. Herein, we report a methodology for the selective oligophosphorylation of peptides with monodisperse phosphate chain lengths (P n =3–6). A library of oligophosphorimidazolide (oligoP-imidazolide) reagents featuring benzyl and o -nitrophenylethyl protecting groups was synthesized in moderate-to-good yields (65–93 %). These oligoP-imidazolide reagents enabled the selective and simultaneous conjugation of multiple phosphate units to phosphoryl nucleophiles, circumventing tedious iterative processes. The generalizability of this approach is illustrated by a substrate scope study that includes several biologically relevant phosphopeptide sequences, culminating in the synthesis of >60 examples of peptide oligophosphates (P n =2–6). Moreover, we report the preparation of oligoP-diimidazolides (P n =3–5) and discuss their application in generating unique condensed phosphate-peptide conjugates. We also demonstrate that human phospho-ubiquitin (pS65-Ub) is amenable to functionalization by our reagents. Overall, we envision the methods described here will enable future studies that characterize these newly discovered but poorly understood phosphorylation modes.}, archive = {J_ANGEW}, author = {Kevin Qian and Björn Hanf and Christopher Cummins and Dorothea Fiedler}, doi = {10.1002/anie.202419147}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202419147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Monodisperse chemical oligophosphorylation of peptides via protected oligophosphorimidazolide reagents}, volume = {64}, year = {2025}, }
• (2025). On-demand nitric oxide generation via thermal decomposition of N-trityl dihydro-1,2-oxazines. ANGEW, 64(11), e202419113. (www)

  @article{ , abstract = {Inhaled nitric oxide (iNO) is a promising therapy for a variety of pulmonary conditions but is limited by the cost, portability, and safety limitations of the compressed gas cylinders used in conventional iNO delivery systems. On-demand generation of iNO via thermally controlled decomposition of an NO-genic precursor is an attractive alternative to systems based on compressed gas cylinders. However, most NO-releasing materials, which would form the basis of such a system, are designed for in vivo applications, but not for gas flow release at elevated temperatures. Novel NO donors with tunable kinetics suited for simple thermal generation are needed to realize such iNO delivery systems. Here we report the development of a new class of NO donors based on N -trityl 3,6-dihydro-1,2-oxazines. We show that amorphous solid dispersions of these molecules in porous polymers exhibit consistent, thermoresponsive NO release in good yields when heated above 90 °C in the presence of a carrier gas. We further demonstrate that these donors undergo NO release in aqueous media at 37 °C. Collectively, this work adds a new class of NO donor to the basis set of known NO-genic molecules and establishes a potential chemical basis for a low-power, small-footprint iNO delivery system.}, archive = {J_ANGEW}, author = {Shuxiao Li and Nathan W. Blackburn and Cassandra L. Ward and Matthew R. Dent and James R. Bour}, doi = {10.1002/anie.202419113}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202419113}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-demand nitric oxide generation via thermal decomposition of N-trityl dihydro-1,2-oxazines}, volume = {64}, year = {2025}, }
• (2025). In/Outside catalytic sites of the pore walls in one-dimensional covalent organic frameworks for oxygen reduction reaction. ANGEW, 64(11), e202418347. (www)

  @article{ , abstract = {Pore channels play a decisive role in mass transport in catalytic systems. However, the influences of the location of catalytic sites inside or outside of the pore walls on the performance were still under-explored due, because it is difficult to construct sites anchored in or outside of pore walls. Herein, one-dimensional covalent organic frameworks with precisely anchored active sites were used to explore the effects of channels on a typical oxygen reduction reaction (ORR) catalysis. Electrocatalytic evaluations showed that single Pt sites located inside of the channels exhibited higher kinetic activity compared to those anchored outside. The in situ spectroscopic analysis revealed that local reconstruction of Pt−Cl breaking and potential-induced anion transport occurred more effectively inside the channels. The superior anion transportability and kinetic activity of the inside-channel active sites also facilitated *OH desorption during the ORR process outperforming their outside-channel counterparts. The results of this study provide strategies for designing active sites in porous catalysts for heterogeneous catalysis.}, archive = {J_ANGEW}, author = {Shuai Yang and Zejin He and Xuewen Li and Bingbao Mei and Yifan Huang and Qing Xu and Zheng Jiang}, doi = {10.1002/anie.202418347}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202418347}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In/Outside catalytic sites of the pore walls in one-dimensional covalent organic frameworks for oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Low-dimensional hetero-interlayer enabling sub-bandgap photovoltaic conversion for perovskite solar cells. ANGEW, 64(11), e202416284. (www)

  @article{ , abstract = {Actualizing sub-band gap photovoltaic conversion is effective in remitting energy loss and pushing theoretical efficiency limits for perovskite solar cells (PSCs). Herein, a zero-dimensional organic metal halide based on hydroxyquinoline (HQ) is developed to sensitize PSCs for near-infrared region gain to implement sub-band gap photovoltaic conversion for enhancing power-conversion-efficiency (PCE) of PSCs. [ZnI 4 ] 2− skeletons containing heavy atoms intensify the direct singlet-to-triplet state transition of organic chromophores HQ. Meanwhile, the triplet energy of HQ is close to resonance with perovskite band gap, favoring the energy transfer to perovskite and exciting the additional electron-hole pairs, which was observed by transient absorption spectroscopy, confirming the sensitization of perovskite to increase sub-band gap photocurrent. HQ 2 ZnI 4 modifies electronic and crystal structure, optimizes energy-level arrangement, and acts as a protective layer, realizing considerable PCEs in small (6.25 mm 2 )-/larger-area (1 cm 2 ) devices and excellent operational stability. This low-cost strategy brings vitality to the light management of PSCs and expands low-dimensional materials.}, archive = {J_ANGEW}, author = {Yutong Wu and Bohong Chang and Hui Li and Lian Wang and Zhen Liu and Longwei Yin}, doi = {10.1002/anie.202416284}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202416284}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-dimensional hetero-interlayer enabling sub-bandgap photovoltaic conversion for perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Regioregular poly(p-phenylene iminoborane): A strictly alternating BN-isostere of poly(p-phenylene vinylene) with stimuli-responsive behavior. ANGEW, 64(11), e202416088. (www)

  @article{ , abstract = {Incorporation of BN units into π-conjugated organic compounds, as substitutes for specific CC couples, often leads to new hybrid materials with modified physical and chemical properties. Poly( p -phenylene iminoborane)s are derived from well-known poly( p -phenylene vinylene) (PPV) by replacement of the vinylene groups by B=N linking units. Herein, an unprecedented poly( p -phenylene iminoborane) is presented that features a strictly alternating sequence of BN units along the main chain. The synthesis thereof was achieved by AB-type polymerization of a monomer featuring an N and a B terminus. Monodisperse oligomers with up to three BN units in the chain were additionally prepared and structurally characterized. Associated with the introduction of a dipole in the regioregular backbone structure, they display notable fluorescence already in solution and large Stokes shifts, distinct from their previously reported BBNN-sequenced congeners. All compounds show aggregation-induced emission enhancement (AIEE) properties. Computational studies provided evidence for emission from either locally excited (LE) or twisted intramolecular charge transfer (TICT) states. These processes can be optionally addressed by various stimuli, giving rise to dual emission, solvatochromic, thermochromic, and reversible mechanochromic behavior.}, archive = {J_ANGEW}, author = {Johannes Chorbacher and Jonas Klopf and Alexandra Friedrich and Maximilian Fest and Johannes S. Schneider and Bernd Engels and Holger Helten}, doi = {10.1002/anie.202416088}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202416088}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioregular poly(p-phenylene iminoborane): A strictly alternating BN-isostere of poly(p-phenylene vinylene) with stimuli-responsive behavior}, volume = {64}, year = {2025}, }
• (2025). Divergent chemoenzymatic synthesis of sulfated ganglio-oligosaccharides for probing ligand requirements of glycan binding proteins. ANGEW, 64(11), e202415521. (www)

  @article{ , abstract = {Sulfoglycolipids are an important class of acidic glycosphingolipids that have been implicated in a multitude of biological processes. Little is known about the interactome of sulfated gangliosides, and it is not well understood how a possible interplay between sialylation and sulfation influences molecular recognition. Here, we describe a chemoenzymatic strategy that readily provided a panel of twenty-one sulfated and sialylated ganglio-oligosaccharides. It is based on the chemical synthesis of a core tetra- and pentasaccharide that are equipped with the orthogonal protecting groups allyloxycarbonate (Alloc), levulinate ester (Lev) and t -butyldimethylsilyl ether (TBS). Selective removal of one or more protecting groups followed by sulfation of the resulting alcohol(s) and deprotecting gave several ganglio-oligosaccharides. Compound lacking an internal sialic acid could be prepared by exposing several derivatives to a sialidase. Compounds having an unmodified terminal galactoside could enzymatically be sialylated to give hybrid structures, which could be further extended to provide 2,8-sialosides. The synthetic glycans were printed as a microarray which was used to examine ligand requirements of a series of glycan-binding proteins including antibodies, toxins, galectins and siglecs. It was found that sulfation regulates protein binding in complex manners and in general sulfation and sialylation of C-3 of the terminal Gal influences protein binding in different ways.}, archive = {J_ANGEW}, author = {Mehman I. Bunyatov and Margreet A. Wolfert and Geert-Jan Boons}, doi = {10.1002/anie.202415521}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202415521}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent chemoenzymatic synthesis of sulfated ganglio-oligosaccharides for probing ligand requirements of glycan binding proteins}, volume = {64}, year = {2025}, }
• (2025). Breaking aggregation state to achieve low-temperature fast charging of lithium metal batteries. ANGEW, 64(11), e202414613. (www)

  @article{ , abstract = {Insufficient ionic conductivity and elevated desolvation energy barrier of electrolytes limit the low-temperature applications of lithium metal batteries (LMBs). Weakly solvating electrolytes (WSEs), with limited lithium salt dissociation capability, are prone to desolvate and drive anion-rich aggregates (AGGs). However, significant AGGs result in increased viscosity and low ionic mobility, contributing to battery failure at low temperatures (≤−20 °C). Here, we propose and achieve a transformation of WSEs’ solvation structures from AGGs to contact ion pairs (CIPs) through modulating the overall solvation capability, thereby achieving the balance between weak Li + - solvent interactions and desired ion migration kinetics. Remarkably, CIPs-dominated electrolyte shows a ten-fold increase in ionic conductivity compared to conventional WSEs. The Li||LiFePO 4 (LFP) battery achieves more than 1400 cycles with 86.9 % capacity retention at 5 C. The practical 1.2 Ah LFP pouch cell delivered 69 % of the capacity at 25 °C when cycled at −40 °C. This strategy for solvation structure transformation in WSEs provides a novel approach for the development of electrolytes for low-temperature batteries.}, archive = {J_ANGEW}, author = {Xiaoyu Guo and Shengtao Xu and Rong Gu and Da Zhang and Shuaiqi Gong and Jinting Xu and Qingwei Gao and Qunjie Xu and Yulin Min}, doi = {10.1002/anie.202414613}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {11}, pages = {e202414613}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking aggregation state to achieve low-temperature fast charging of lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Self-assembly of amorphous 2D polymer nanodiscs with tuneable size, pH-responsive degradation and controlled drug release. ANGEW, 64(10), e202581062. (www)

  @article{ , archive = {J_ANGEW}, author = {Haoxiang Zeng and Ping Zeng and Jinsu Baek and Byeong-Su Kim and Markus Müllner}, doi = {10.1002/anie.202581062}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202581062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Self-assembly of amorphous 2D polymer nanodiscs with tuneable size, pH-responsive degradation and controlled drug release}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Conformational plasticity and binding affinity enhancement controlled by linker derivatization in macrocycles. ANGEW, 64(10), e202581061. (www)

  @article{ , archive = {J_ANGEW}, author = {Vanessa Buffa and Carlo Walz and Christian Meyners and Min Zheng and Wisely Oki Sugiarto and Maximilian Repity and Hanaa Achaq and Christian Brudy and Moritz Spiske and Matijas Cica and Felix Hausch}, doi = {10.1002/anie.202581061}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202581061}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Conformational plasticity and binding affinity enhancement controlled by linker derivatization in macrocycles}, volume = {64}, year = {2025}, }
• (2025). Back cover: Electrocatalytic micelle-driven hydrodefluorination for accessing unprotected monofluorinated indoles (Angew. chem. int. ed. 10/2025). ANGEW, 64(10), e202502488. (www)

  @article{ , archive = {J_ANGEW}, author = {Karanjeet Kaur and Raki Mandal and Justin R. Walensky and Fabrice Gallou and Sachin Handa}, doi = {10.1002/anie.202502488}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202502488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Electrocatalytic micelle-driven hydrodefluorination for accessing unprotected monofluorinated indoles (Angew. chem. int. ed. 10/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Bridging electrolyte bulk and interfacial chemistry: Dynamic protective strategy enable ultra-long lifespan aqueous zinc batteries (Angew. chem. int. ed. 10/2025). ANGEW, 64(10), e202502397. (www)

  @article{ , archive = {J_ANGEW}, author = {Qing Wu and Jinlong Zhang and Song Yang and Fusheng Luo and Zeyu Yan and Xiude Liu and Haibo Xie and Jun Huang and Yiwang Chen}, doi = {10.1002/anie.202502397}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202502397}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Bridging electrolyte bulk and interfacial chemistry: Dynamic protective strategy enable ultra-long lifespan aqueous zinc batteries (Angew. chem. int. ed. 10/2025)}, volume = {64}, year = {2025}, }
• (2025). Qi zhang. ANGEW, 64(10), e202502124. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202502124}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202502124}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Qi zhang}, volume = {64}, year = {2025}, }
• (2025). Natalie boehnke. ANGEW, 64(10), e202501902. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202501902}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202501902}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Natalie boehnke}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: Correction to “Capturing the interplay between TADF and RTP through mechanically flexible polymorphic optical waveguides”. ANGEW, 64(10), e202501737. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202501737}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202501737}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: Correction to “Capturing the interplay between TADF and RTP through mechanically flexible polymorphic optical waveguides”}, volume = {64}, year = {2025}, }
• (2025). Ultrasound-enhanced spleen-targeted mRNA delivery via fluorinated PEGylated lipid nanoparticles for immunotherapy. ANGEW, 64(10), e202500878. (www)

  @article{ , abstract = {Lipid nanoparticles (LNPs) based messenger RNA (mRNA) therapeutics hold immense promise for treating a wide array of diseases, while their nonhepatic organs targeting and insufficient endosomal escape efficiency remain challenges. For LNPs, polyethylene glycol (PEG) lipids have a crucial role in stabilizing them in aqueous medium, but they severely hinder cellular uptake and reduce transfection efficiency. In this study, we designed ultrasound (US)-assisted fluorinated PEGylated LNPs (F-LNPs) to enhance spleen-targeted mRNA delivery and transfection. Through liquid-to-gas phase transition, we enabled the controlled shedding of fluorinated PEG lipids from F-LNPs, facilitating cellular uptake, membrane fusion, and mRNA release. In vivo results demonstrated that US-assisted F-LNPs increased mRNA transfection approximately 4.0-fold in the spleen following intravenous administration. Notably, the F-LNPs achieved effective mRNA delivery to antigen-presenting cell subsets, such as dendritic cells, macrophages, and B cells. The targeted delivery of full-length ovalbumin-encoding mRNA vaccine induced significant CD8 + T cell response and exhibited excellent therapeutic effect against the ovalbumin-transduced B16F10 tumor model. These findings establish a novel strategy for spleen-specific mRNA delivery through the combination of fluorinated PEG lipids and US treatment, which holds substantial promise for enhancing the efficacy of immunotherapy, potentially broadening the scope of clinical applications for mRNA-based therapy.}, archive = {J_ANGEW}, author = {Minglong Chen and Jie Cen and Qiangqiang Shi and Bing Shao and Jiajia Tan and Xianjun Ye and Zhihua He and Yang Liu and Guoying Zhang and Jinming Hu and Jianqiang Bao and Shiyong Liu}, doi = {10.1002/anie.202500878}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202500878}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrasound-enhanced spleen-targeted mRNA delivery via fluorinated PEGylated lipid nanoparticles for immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Multi-resonance 1,4-BN-heteroarene for filterless narrowband photodetector. ANGEW, 64(10), e202500006. (www)

  @article{ , abstract = {As an emerging class of optoelectronic materials, multi-resonance (MR) 1,4-BN-heteroarenes have been extensively employed as narrowband electroluminescence materials, whereas their absorption feature has largely been neglected. Here we construct the first MR-molecule-based phototransistor for filterless narrowband photodetectors (NBPDs) by anchoring narrowband absorption MR molecules on a high-mobility semiconductor indium-zinc-oxide (IZO) film. The resulting device exhibits high-performance photodetection with a small full-width at half-maximum (FWHM) of 33 nm, which represents a new record for NBPDs based on intrinsic narrowband absorbing materials. These results demonstrate the great potential of MR materials as a new molecular platform for developing high-performance NBPDs.}, archive = {J_ANGEW}, author = {Rong-Rong Gao and Cheng Chen and Yan-Bo Huang and Xiao-Ye Wang}, doi = {10.1002/anie.202500006}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202500006}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-resonance 1,4-BN-heteroarene for filterless narrowband photodetector}, volume = {64}, year = {2025}, }
• (2025). Axially chiral TADF imidazolium salts for circularly polarized light-emitting electrochemical cells. ANGEW, 64(10), e202425094. (www)

  @article{ , abstract = {A pair of axially chiral thermally activated delayed fluorescent (TADF) enantiomers, R - TCBN-ImEtPF 6 and S - TCBN-ImEtPF 6 , with intrinsic ionic characteristics were efficiently synthesized by introducing imidazolium hexafluorophosphate to chiral TADF unit. The TADF imidazolium salts exhibited a high photoluminescence quantum yield (PLQY) of up to 92 %, a small singlet–triplet energy gap (▵ E ST ) of 0.04 eV, as well as reversible redox properties. Furthermore, the enantiomers showed distinct mirror-image CD and CPL activities with g lum values of −3.7×10 −3 and +3.4×10 −3 . Notably, by doping the axial TADF imidazolium salts into achiral TADF sensitizer, sandwich-structured light-emitting electrochemical cells (LECs) without the addition of ionic liquids (ILs) or ionic transition-metal compounds (iTMCs) were fabricated. When driven at 50 A m −2 , the LECs displayed an EQE of up to 5.2 % and strong circularly polarized electroluminescence (CPEL) with g EL values of +3.3×10 −3 and −3.0×10 −3 . This represents the first CP-LEC based on TADF materials and offers a promising strategy for the development of high-performance CPEL devices.}, archive = {J_ANGEW}, author = {Chao Feng and Ke Zhang and Bianxiang Zhang and Liheng Feng and Lei He and Chuan-Feng Chen and Meng Li}, doi = {10.1002/anie.202425094}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202425094}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Axially chiral TADF imidazolium salts for circularly polarized light-emitting electrochemical cells}, volume = {64}, year = {2025}, }
• (2025). Cover picture: One-step esterification of phosphoric, phosphonic and phosphinic acids with organosilicates: Phosphorus chemical recycling of sewage waste (Angew. chem. int. ed. 10/2025). ANGEW, 64(10), e202425010. (www)

  @article{ , archive = {J_ANGEW}, author = {Yuki Naganawa and Kei Sakamoto and Akira Fujita and Kazuya Morimoto and Manussada Ratanasak and Jun-ya Hasegawa and Masaru Yoshida and Kazuhiko Sato and Yumiko Nakajima}, doi = {10.1002/anie.202425010}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202425010}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: One-step esterification of phosphoric, phosphonic and phosphinic acids with organosilicates: Phosphorus chemical recycling of sewage waste (Angew. chem. int. ed. 10/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Benzylic C−H radical sulfation by persulfates (Angew. chem. int. ed. 10/2025). ANGEW, 64(10), e202425007. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhen Xia and Zhongyao Ye and Ting Deng and Ze Tan and Chunlang Song and Jiakun Li}, doi = {10.1002/anie.202425007}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202425007}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Benzylic C−H radical sulfation by persulfates (Angew. chem. int. ed. 10/2025)}, volume = {64}, year = {2025}, }
• (2025). Self-assembly of amorphous 2D polymer nanodiscs with tuneable size, pH-responsive degradation and controlled drug release. ANGEW, 64(10), e202424269. (www)

  @article{ , abstract = {Amphiphilic bottlebrush block copolymers (BBCs) with tadpole-like, coil-rod architecture can be used to self-assemble into functional polymer nanodiscs directly in water. The hydrophobic segments of the BBC were tuned via the ratio of ethoxy-ethyl glycidyl ether (EE) to tetrahydropyranyl glycidyl ether (TP) within the grafted polymer sidechains. In turn, this variation controlled the sizes, pH-responsiveness, and drug loading capacity of the self-assembled nanodiscs. Notably, as EE exhibited faster hydrolysis than TP, the nanodiscs featured variable degradation rates under mild acidic conditions, aiding small molecule release and time-dependent and complete degradation of discs into fully water-soluble copolymers. The nanodiscs demonstrated biocompatibility and cellular uptake by breast cancer cells, underscoring their potential development into drug delivery systems.}, archive = {J_ANGEW}, author = {Haoxiang Zeng and Ping Zeng and Jinsu Baek and Byeong-Su Kim and Markus Müllner}, doi = {10.1002/anie.202424269}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202424269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembly of amorphous 2D polymer nanodiscs with tuneable size, pH-responsive degradation and controlled drug release}, volume = {64}, year = {2025}, }
• (2025). Ph3PC – A monosubstituted c(0) atom in its triplet state. ANGEW, 64(10), e202424166. (www)

  @article{ , abstract = {This study introduces a novel class of carbon-centered diradicals: a monosubstituted C atom stabilized by a phosphine. The diradical Ph 3 P→C was photochemically generated from a diazophosphorus ylide precursor (Ph 3 PCN 2 ) and characterized by EPR and isotope-sensitive ENDOR spectroscopy at low temperatures. Ph 3 P→C features an axial zero-field splitting parameter D =0.543 cm −1 with a vanishingly small rhombicity | E |/ D =0.002. Time- and temperature-dependent measurements confirm a triplet ground state with a lifetime of approximately 10 min at 127 K in toluene-d 8 . Multireference electronic structure calculations predict a clear triplet ground state with a singlet-triplet gap greater than 20 kcal/mol. In contrast to divalent C(0) compounds, such as Ph 3 P→C←PPh 3 , in which carbon needs excitation into a highly-excited closed-shell 2s 0 2p 4 configuration, Ph 3 P→C can be explained by direct involvement of carbon in its natural 3 P state arising from the 2s 2 2p 2 configuration.}, archive = {J_ANGEW}, author = {Yury Kutin and Taichi Koike and Maria Drosou and Alexander Schnegg and Dimitrios A. Pantazis and Müge Kasanmascheff and Max M. Hansmann}, doi = {10.1002/anie.202424166}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202424166}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ph3PC – A monosubstituted c(0) atom in its triplet state}, volume = {64}, year = {2025}, }
• (2025). Kauzmann paradox, supercooling, and finding order in chaos. ANGEW, 64(10), e202423536. (www)

  @article{ , abstract = {Prediction of a liquidus state with lower entropy than the corresponding solid at Kauzmann temperature ( T k ), and associated entropy catastrophe/paradox, remains an enigma. Despite efforts to resolve this paradox for nearly 80 years, no unifying resolution has been reported. Potential resolutions to the Kauzmann paradox rely on an ideal glass transition, however, this limits the interpretation of T k as an equilibrium critical point rather than an instability. Focusing on entropy, statistical mechanics and non-equilibrium dynamics becomes a key tenet in resolving this paradox. Expansion in phase space beyond 2D and consideration of T k as a non-equilibrium critical point is necessary to understand the extent of liquid relaxation beyond T k . In this review, we provide an entropic perspective of the relaxation behavior of supercooled liquids, associated expanded phase diagram, and the potential resolution to the Kauzmann paradox. This work integrates the historical evolution of our understanding of entropy/thermodynamics with modern interpretation of quantum states through renormalization group and thermodynamic speed limits.}, archive = {J_ANGEW}, author = {Andrew Martin and Martin Thuo}, doi = {10.1002/anie.202423536}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202423536}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Kauzmann paradox, supercooling, and finding order in chaos}, volume = {64}, year = {2025}, }
• (2025). Stable luminescent diradicals: The emergence and potential applications. ANGEW, 64(10), e202423470. (www)

  @article{ , abstract = {Stable luminescent diradicals, characterized by the presence of two unpaired electrons, exhibit unique photophysical properties that are sensitive to external stimuli such as temperature, magnetic fields, and microwaves. This sensitivity allows the manipulation of their spin states and luminescence, setting them apart from traditional closed-shell luminescent molecules and luminescent monoradicals. As a result, luminescent diradicals are emerging as promising candidates for a variety of applications. This minireview discusses recent advances in the design and synthesis of luminescent diradicals, explores their photophysical properties and potential applications. It also examines the challenges and prospects in the development of these materials, shedding light on their potential to drive technological innovation.}, archive = {J_ANGEW}, author = {Yujie Zhu and Zihao Zhu and Saixue Wang and Qiming Peng and Alim Abdurahman}, doi = {10.1002/anie.202423470}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202423470}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable luminescent diradicals: The emergence and potential applications}, volume = {64}, year = {2025}, }
• (2025). Radical homopolymerization of arylsulfonylated α-olefins to synthesize polysulfones – A “SO2-free” approach. ANGEW, 64(10), e202421906. (www)

  @article{ , abstract = {Traditionally, α-olefins have been regarded as non-homopolymerizable substrates in textbook examples. However, they have the ability to copolymerize with sulfur dioxide, leading to the creation of alternating copolymers. These commodity poly(olefin sulfone)s exhibit a wide array of applications. Nevertheless, the synthesis process involving sulfur dioxide pose considerable hazards and practical difficulties. In this study, we report on the “SO 2 -free” radical homopolymerization of sulfonyl α-olefin monomers, resulting in the production of ABC sequence-controlled poly(vinylbenzothiazole-olefin-sulfone)s. This unique radical polymerization process is enhanced by 1,4/1,5-aryl migration, facilitated by the sulfonyl radicals involved in propagation. This demonstrated aryl group migration radical polymerization opens up new possibilities for synthesizing polysulfones with unprecedented main chain sequences and structures, which hold great promise as candidates for innovative polymeric materials.}, archive = {J_ANGEW}, author = {Bang An and Lixing Sun and Tingting Sun and Yifan Li}, doi = {10.1002/anie.202421906}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421906}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radical homopolymerization of arylsulfonylated α-olefins to synthesize polysulfones – A “SO2-free” approach}, volume = {64}, year = {2025}, }
• (2025). Engineered Metal–Organic framework with stereotactic anchoring and spatial separation of porphyrins for amplified ultrasound-mediated pyroptosis and cancer immunotherapy. ANGEW, 64(10), e202421402. (www)

  @article{ , abstract = {Ultrasound-mediated reactive oxygen species (ROS) generation is pivotal in specifically inducing pyroptosis of tumor cells. However, the effectiveness of pyroptosis is generally hindered by the constraints of ROS generation efficiency. Herein, a new porphyrin-based metal–organic framework (Fe(TCPP)-MOF) was rationally designed via an innovative dual-solvent strategy to amplify ROS generation for ultrasound-controlled pyroptosis. The crystal structure of Fe(TCPP)-MOF was elucidated by continuous rotation electron diffraction technique, revealing its regular and rigid conformation. The porphyrin molecules were precisely oriented and firmly confined within the scaffold, effectively restricting intramolecular motion. The ample distance of 6.8 Å between two porphyrin molecules, combined with the interaction region indicator visualization, confirmed the absence of π–π stacking interactions in the Fe(TCPP)-MOF framework, thereby avoiding the aggregation-caused quenching effect. Furthermore, the permanent porosity and expansive surface area of Fe(TCPP)-MOF enhanced its interaction with oxygen. These ingenious structural features endowed Fe(TCPP)-MOF with a unique ability to generate a large amount of singlet oxygen under ultrasound activation. Meanwhile, the impetus of ultrasound also accelerated the rate of the Fenton reaction catalyzed by iron ions, significantly boosting the generation of hydroxyl radicals. Benefiting from the dual amplification of ROS, Fe(TCPP)-MOF could efficiently induce tumor cells pyroptosis under ultrasound stimulation, thereby intensifying the potency of cancer immunotherapy.}, archive = {J_ANGEW}, author = {Sainan Liu and Qi Meng and Zhendong Liu and Jiwei Wang and Jing Li and Xinyu Ma and Yarui Hu and Zhanfeng Wang and Ping'an Ma and Jun Lin}, doi = {10.1002/anie.202421402}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered Metal–Organic framework with stereotactic anchoring and spatial separation of porphyrins for amplified ultrasound-mediated pyroptosis and cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Unsymmetric protonation driven highly efficient H2O2 photosynthesis in supramolecular photocatalysts via one-step two-electron oxygen reduction. ANGEW, 64(10), e202421356. (www)

  @article{ , abstract = {Photocatalytic hydrogen peroxide (H 2 O 2 ) production has emerged as an attractive alternative to the traditional anthraquinone process. However, its performance is often hindered by low selectivity and sluggish kinetics of oxygen reduction reaction (ORR). Herein, we report an anthrazoline-based supramolecular photocatalyst, SA - SADF - H + , featuring an unsymmetric protonation structure for H 2 O 2 photosynthesis from water and air. The introduction of unsymmetric protonation disrupts the initial mirror symmetry of SADF , significantly enhancing the molecular dipole and facilitating efficient charge separation and electron transfer. Additionally, this modification increases the hydrophilicity of SA - SADF - H + , enabling the interaction of water and dissolved oxygen with the catalytic sites. The altered electron density distribution creates numerous dual active sites for Yeager-type O 2 adsorption, facilitating an efficient ORR towards H 2 O 2 via a direct one-step two-electron pathway. Notably, SA-SADF - H + achieves an outstanding photocatalytic H 2 O 2 production at a rate of 4666.7 μmol L −1 h −1 , with a remarkable solar-to-chemical conversion (SCC) of 1.35 %, surpassing most organic photocatalytic systems. Furthermore, SA - SADF - H + demonstrates remarkable photocatalytic antibacterial activity, achieving 100 % antibacterial efficiency against Staphylococcus aureus within 60 min.}, archive = {J_ANGEW}, author = {Wenting Li and Bing Han and Yuhan Liu and Jingyi Xu and Huarui He and Gege Wang and Junshan Li and Yaxin Zhai and Xiaolin Zhu and Yongfa Zhu}, doi = {10.1002/anie.202421356}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421356}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unsymmetric protonation driven highly efficient H2O2 photosynthesis in supramolecular photocatalysts via one-step two-electron oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). Interface-engineering-induced C−C coupling for C2H4 photosynthesis from atmospheric-concentration CO2 reduction. ANGEW, 64(10), e202421353. (www)

  @article{ , abstract = {Producing ethylene (C 2 H 4 ) from carbon dioxide (CO 2 ) photoreduction under mild conditions is primarily restricted by the difficulty of C−C coupling. Herein, we designed highly active metal atom clusters anchored on semiconductor nanosheets, which established heteroatom sites on the interface to steer C−C coupling, realizing air-concentration CO 2 photoreduction into C 2 H 4 in pure water. As an example, the Pd nanoclusters loaded on ZnO nanosheets are prepared, demonstrated by the X-ray photoelectron spectroscopy and high-angle annular dark-field image. In situ Fourier transform infrared spectroscopy confirms the C−C coupling step over the Pd-ZnO nanosheets, while quasi in situ X-ray photoelectron spectroscopy illustrates the active sites of Pd and Zn atoms on the Pd-ZnO nanosheets during CO 2 photoreduction. Density functional theoretical calculations unveil the transition state energy barrier of C−C coupling of CO* and COH* intermediates are only 0.998 eV, hinting the easy C−C coupling to produce C 2 fuels. Therefore, the Pd-ZnO nanosheets realize C 2 H 4 photosynthesis by atmospheric-concentration CO 2 reduction with the formation rate of 1.03 μmol g −1 h −1 , while the ZnO nanosheets only acquired the carbon monoxide product.}, archive = {J_ANGEW}, author = {Peijin Du and Jinyu Ding and Chengyuan Liu and Peipei Li and Wenxiu Liu and Wensheng Yan and Yang Pan and Jun Hu and Junfa Zhu and Xiaodong Li and Qingxia Chen and Xingchen Jiao}, doi = {10.1002/anie.202421353}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interface-engineering-induced C−C coupling for C2H4 photosynthesis from atmospheric-concentration CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Anomalous role of carbon in pd-catalyzed selective hydrogenation. ANGEW, 64(10), e202421351. (www)

  @article{ , abstract = {Carbonaceous species, including subsurface carbidic carbon and surface carbon, play crucial roles in heterogeneous catalysis. Many reports suggested the importance of subsurface carbon in the selective hydrogenation of alkynes over Pd-based catalysts. However, the role of surface carbon has been largely overlooked. We demonstrate that subsurface carbon in Pd is not responsible for the selectivity in acetylene hydrogenation. In contrast, the structure of surface carbonaceous species plays a decisive role in hydrogenation selectivity. Electron microscopy and spectroscopy evidence, along with theoretical modelling, reveal that partial graphitization of surface carbonaceous species results in unique spatial confinement of surface reaction intermediates, thus altering the reaction energy landscape in favour of ethylene desorption as opposed to over-hydrogenation. This mechanism for selectivity control is analogous to enzyme catalysis, where the active centers selectively attract reactants and release products. Similar mechanism may be present in CO/CO 2 hydrogenation and alkane dehydrogenation reactions.}, archive = {J_ANGEW}, author = {Peng Zhai and Divakar R. Aireddy and Mark B. Berko and Ahmad Arshadi and Michael J. Zachman and David A. Cullen and Ye Xu and Kunlun Ding}, doi = {10.1002/anie.202421351}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421351}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anomalous role of carbon in pd-catalyzed selective hydrogenation}, volume = {64}, year = {2025}, }
• (2025). MOF-based dual-layer pickering emulsion: Molecular-level gating of water delivery at water-oil interface for efficient photocatalytic hydrogenation using H2O as a hydrogen source. ANGEW, 64(10), e202421341. (www)

  @article{ , abstract = {Biphasic system not only presents a promising opportunity for complex catalytic processes, but also is a grand challenge in efficient tandem reactions. As an emerging solar-to-chemical conversion, the visible-light-driven and water-donating hydrogenation combines the sustainability of photocatalysis and economic-value of hydrogenation. However, the key and challenging point is to couple water-soluble photocatalytic hydrogen evolution reaction (HER) with oil-soluble hydrogenation. Herein, we employed metal–organic frameworks (MOFs) and CdS nanorods to construct a MOF-CdS dual-layer Pickering emulsion (water in oil, W/O), which compartmented aqueous phase for photocatalytic HER and oil phase for hydrogenation. The hydrophobic MOF and hydrophilic CdS were isolated at the inner and outer layers of W/O emulsion, respectively. The molecularly regulated hydrophobicity of MOF controlled the water delivery onto CdS photocatalysts, which realized the synergistic regulation of HER and hydrogenation. In the photocatalytic hydrogenation of cinnamaldehyde, the highest yield of MOF-CdS Pickering emulsion reached 187.37 mmol ⋅ g −1 ⋅ h −1 , 30 times that of the counterpart without emulsion (6.44 mmol ⋅ g −1 ⋅ h −1 ). Its apparent quantum yield reached 43.24 % without co-catalysts. To our knowledge, this performance is at a top-level so far. Our work realized the precise regulation of water-oil interface to effectively couple two reactions in different phases, providing new perspective for challenging tandem catalysis.}, archive = {J_ANGEW}, author = {Kuo Yuan and Ying Zhang and Zhuang Yan and Qinbai Yun and Tianqun Song and Jun Guo and Jie Feng and Zheng Chen and Xiaotao Zhang and Zhiyong Tang and Wenping Hu and Tongbu Lu}, doi = {10.1002/anie.202421341}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421341}, shortjournal = {Angew. Chem. Int. Edit.}, title = {MOF-based dual-layer pickering emulsion: Molecular-level gating of water delivery at water-oil interface for efficient photocatalytic hydrogenation using H2O as a hydrogen source}, volume = {64}, year = {2025}, }
• (2025). Ion mobility mass spectrometry to probe sequences in supramolecular copolymers. ANGEW, 64(10), e202421328. (www)

  @article{ , abstract = {The analysis of the microstructure of supramolecular copolymers is difficult because of their dynamic character. Here, benzene-1,3,5-tricarboxamide (BTA) co-assemblies are analysed by ion mobility – mass spectrometry (IM–MS) to reveal the presence of various sequences. For example, the IM–MS mobilogram for hexamers composed of 4 units from a first monomer and 2 units from a second monomer is a broad distribution due to the presence of 9 possible isomeric sequences, which can be sorted out based on calculated collision cross-sections. This approach gives unprecedented information on supramolecular copolymer sequences.}, archive = {J_ANGEW}, author = {Cédric Przybylski and Patrick Brocorens and Laetitia-Eiko Xerri and Antoine Perennes and Geoffrey Gontard and Roberto Lazzaroni and Matthieu Raynal and Laurent Bouteiller}, doi = {10.1002/anie.202421328}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421328}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ion mobility mass spectrometry to probe sequences in supramolecular copolymers}, volume = {64}, year = {2025}, }
• (2025). Scalable and precise synthesis of structurally colored bottlebrush block copolymers: Enabling refined color calibration for sustainable photonic pigments. ANGEW, 64(10), e202421315. (www)

  @article{ , abstract = {Self-assembled bottlebrush block copolymers (BBCPs) offer a vibrant, eco-friendly alternative to traditional toxic pigments and dyes, providing vivid structural colors with significantly reduced environmental impact. Scaling up the synthesis of these polymers for practical applications has been challenging with conventional batch methods, which suffer from slow mass and heat transfer, inadequate mixing, and issues with reproducibility. Precise control over molecular weight and dispersity remains a significant challenge for achieving finely tuned color appearances. Here, we present an alternative strategy to overcome the challenges by integrating a rapid continuous flow technique with an in-line self-assembly procedure. This strategy enables the rapid, stable and large-scale synthesis of narrow-dispersed BBCPs, exceeding 2 kg/day, a significant improvement over conventional gram-scale methods. Furthermore, precise control over the degree of polymerization is achieved with an unprecedented interval accuracy of four repeat units. This level of precision enables refined color calibration in the resulting photonic pigments, effectively eliminating the need for labor-intensive and costly multiple batch syntheses.}, archive = {J_ANGEW}, author = {Bangbang Wang and Kunyu Zhang and Li Pan and Yuesheng Li and Dong-Po Song}, doi = {10.1002/anie.202421315}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421315}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable and precise synthesis of structurally colored bottlebrush block copolymers: Enabling refined color calibration for sustainable photonic pigments}, volume = {64}, year = {2025}, }
• (2025). Coaxial helices in chiral supramolecular aggregates from highly hindered chiral allenes. ANGEW, 64(10), e202421310. (www)

  @article{ , abstract = {Chiral allenes self-assembly following a cooperative mechanism into a supramolecular chiral aggregate consisting of two coaxial helices: the internal helix described by the allene stack and the external helix which consist in a 4-helix described by the four allene substituents. More precisely, this supramolecular aggregate possesses six axially chiral elements within its structure—the allene, the allene stack (internal helix) and the stacks of the four allene substituents (external 4-helix)—. Interestingly, slight variations in the magnitude of the tilting degree while keeping its P - or M - orientation (internal helix) can vary the orientation of the 4-axial motifs at the external helix. Thus, while ( P )- 1 produces a supramolecular helix with a Θ ca. 15° ( P int ) and a M 1 / P 2 / M 1’ / P 2’ orientation of the four axial motifs at the periphery, ( P )- 2 produces a supramolecular helix with a Θ ca. 23° ( P int ) and a P 1 / P 2 / P 1’ / P 2’ orientation of the four axial motifs at the external helix. As a result, the ECD spectra and the AFM images of the ( P )- 1 and ( P )- 2 supramolecular aggregates dominated by the 1 and 1’ substituents of the chiral allene indicate opposite handedness although the chirality of the building block and the orientation of the allene stack are the same}, archive = {J_ANGEW}, author = {María Lago-Silva and Manuel Fernández-Míguez and Zulema Fernández and María Magdalena Cid and Emilio Quiñoá and Rafael Rodríguez and Félix Freire}, doi = {10.1002/anie.202421310}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421310}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coaxial helices in chiral supramolecular aggregates from highly hindered chiral allenes}, volume = {64}, year = {2025}, }
• (2025). Rhodium-mediated assembly of new heterocycles: From borylenes to oxaboroles. ANGEW, 64(10), e202421302. (www)

  @article{ , abstract = {Base-stabilized rhodium borylene complex κ 2 - L (CO)Rh(BMes), 2 ; κ 2 - L = κ 2 -NN’-Rh, κ 1 -N−B-(2,5-[ i Pr 2 P=N(4- i PrC 6 H 4 )] 2 -N ’ (C 4 H 2 ) − ); Mes=mesityl, reacts with a series of alkynes (PhC≡C—R; R=Ph, Me, CO 2 Et, H) to yield unique structures whereby the alkyne has regioselectively added across boron and the carbon atom of a CO ligand. The resulting complexes, L Rh[C(O)C(Ph)C(R)B(Mes)], 3 R , react with additional CO to afford cycle-containing products, L (CO)Rh ), 5 R , that ultimately release highly functionalized organic heterocycles of the form =NPipp (Pipp=4- i PrC 6 H 4 ), 6 . These oxaboroles, which were assembled from a primary hydroborane, CO, an alkyne, and an azide-generated NPipp, are structurally analogous to two of the five boron-containing therapeutics approved by the FDA.}, archive = {J_ANGEW}, author = {Shou-Jen Hsiang and Paul G. Hayes}, doi = {10.1002/anie.202421302}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421302}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhodium-mediated assembly of new heterocycles: From borylenes to oxaboroles}, volume = {64}, year = {2025}, }
• (2025). Supramolecular rotor assembly for the design of a hybrid ferroelectric-antiferromagnetic multiferroic semiconductor. ANGEW, 64(10), e202421298. (www)

  @article{ , abstract = {Ferroelectric (FE)-antiferromagnetic (AFM) multiferroic materials have sparked growing interest due to their huge possibilities in energy-saving, photoelectric devices, nonvolatile storage, and switches. However, realizing FE-AFM properties in a hybrid molecular material is difficult because ferroelectric and magnetic orders are commonly mutually exclusive. Here, we report an FE-AFM multiferroic semiconductor [NH 4 (18-crown-6)] 2 [Mn(SCN) 4 ] ( NCMS ) by supramolecular assembly approach via molecular rotor synthon [NH 4 (18-crown-6)] and inorganic magnetic module [Mn(SCN) 4 ]. Interestingly, NCMS shows good ferroelectricity with a spontaneous polarization ( P s ) of 5.94 μC cm −2 higher than most crown-ether-based ferroelectrics. Especially, the realization of antiferromagnetism is for the first time in the crown ether hybrid perovskite ferroic systems. Additionally, semiconductor NCMS displays an X-ray radiation detection response with a large photo/dark current on-off ratio (197). Our study not only gives a deep insight into understanding multiferroic properties but also provides a novel and efficient approach to realizing high-performance hybrid multiferroic materials.}, archive = {J_ANGEW}, author = {Na Wang and Hua-Kai Li and Huai-Yi Shen and Le Ye and Ze-Jiang Xu and Mei-Ling Ren and Nian-Tao Yao and Chao Shi and Heng-Yun Ye and Le-Ping Miao}, doi = {10.1002/anie.202421298}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421298}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular rotor assembly for the design of a hybrid ferroelectric-antiferromagnetic multiferroic semiconductor}, volume = {64}, year = {2025}, }
• (2025). Precisely tailoring the second coordination sphere of a cobalt single-atom catalyst for selective hydrogenation of halogenated nitroarenes. ANGEW, 64(10), e202421277. (www)

  @article{ , abstract = {The development of highly efficient and cost-effective nonprecious metal catalysts for the selective hydrogenation of halogenated nitroarenes is very appealing yet challenging. Here, we demonstrate that the hydrogenation activity and selectivity of Co single-atom catalyst (SAC) can be tuned by tailoring the structure of second coordination sphere via P doping. As revealed by synchrotron radiation-based X-ray absorption spectroscopy characterizations, such a P doping on N-coordinated Co SAC results in the unsymmetric Co-N 4 P 1 coordination structure. With a combination of experimental characterizations and theoretical simulations, we find that tailoring the second coordination sphere can greatly improve H 2 dissociation and product desorption. As a result, the Co-N 4 P 1 SAC exhibits superior activity, selectivity and stability for the hydrogenation of halogenated nitroarenes to corresponding amines (20 examples, >99 % yields) at 80 °C under 0.5 MPa H 2 pressure, significantly outperforming most heterogeneous catalysts reported in the literature. We expect that this work opens a new avenue for the design of highly efficient nonprecious metal SACs for important hydrogenation reactions.}, archive = {J_ANGEW}, author = {Guangyu Chen and Juwen Gu and Wanbing Gong and Jiawei Li and Jiayi Li and Songbai Qiu and Ran Long and Huijun Zhao and Yujie Xiong}, doi = {10.1002/anie.202421277}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421277}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precisely tailoring the second coordination sphere of a cobalt single-atom catalyst for selective hydrogenation of halogenated nitroarenes}, volume = {64}, year = {2025}, }
• (2025). A small-molecule drug for the self-checking of mitophagy. ANGEW, 64(10), e202421269. (www)

  @article{ , abstract = {Mitophagy, particularly in the context of drugs that disrupt mitochondrial membrane potential (MMP), represents a critical focus in pharmacology. However, the discovery and evaluation of MMP-disrupting drugs are often hampered using commercially available marker molecules that target similar or identical zones. These markers can significantly interfere with, obscure, or amplify the functional effects of MMP-targeting drugs, frequently leading to clinical failures. In response to this challenge, we propose a “one-two punch” drug design strategy that integrates both target-zone drug functionality and non-target zone biological reporting within a single small-molecule drug. We have developed a novel proof-of-concept mitophagy self-check drug ( MitoSC ) that exhibits dual-color and dual-localization properties. The functional component of this system is a variable MitoSC that disrupts mitochondrial membrane potential (MMP) homeostasis, thereby inducing mitophagy. Upon activation, this component transforms into a blue-fluorescent monomer ( MitoSC-fun ) specifically within the mitochondrial target zone. Concurrently, the biological reporting component is represented by a red-fluorescent monomer ( MitoSC-rep ) that localizes to lysosomes, the non-target zone. As mitophagy progresses, the fluorescent signals from MitoSC-rep (lysosomes) and MitoSC-fun (mitochondria) converge, enabling real-time monitoring of the mitophagic process. This strategy combines potent drug functionality with robust biological reporting, thereby minimizing interference and eliminating the complexities associated with external detection. Our findings underscore the potential of a single-molecule drug to exert target-zone specific actions while simultaneously providing non-target zone self-checking, offering a new perspective for drug design.}, archive = {J_ANGEW}, author = {Yanan Gao and Qingjie Bai and Youxiao Ren and Xintian Shao and Mengrui Zhang and Luling Wu and Simon E. Lewis and Tony D. James and Xiaoyuan Chen and Qixin Chen}, doi = {10.1002/anie.202421269}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A small-molecule drug for the self-checking of mitophagy}, volume = {64}, year = {2025}, }
• (2025). Remote carbon monoxide spillover improves tandem urea electrosynthesis. ANGEW, 64(10), e202421266. (www)

  @article{ , abstract = {Electrocatalytic urea synthesis from carbon dioxide (CO 2 ) and nitrate (NO 3 − ) offers a promising alternative to traditional industrial methods. However, current catalysts face limitations in the supplies of CO* and N related * intermediates, and their coupling, resulting in unsatisfactory urea production efficiency and energy consumption. To overcome these challenges, we carried out tandem electrosynthesis approach using ruthenium dioxide-supported palladium-gold alloys (Pd 2 Au 1 /RuO 2 ). This catalyst system effectively catalyzes CO 2 -to-CO* conversion on Pd 2 Au 1 and NO 3 − -to-NH 2 * conversion on RuO 2 . Crucially, the minimized work function difference between two components promotes remote CO* spillover from Pd 2 Au 1 to RuO 2 , improving effective coupling of CO* and NH 2 * for urea production. Our catalyst demonstrated exceptional performance, achieving a record-high Faradaic efficiency for urea (FE urea ) of 75.6±0.5 % and a urea production rate ( r urea ) of 73.5±0.8 mmol g cat −1 h −1 . Notably, this was accomplished with an ultralow energy consumption of 18.9 kWh kg urea −1 . We also successfully demonstrate the long-term stability of our catalyst in a flow cell, achieving over 160 h of uninterrupted urea and formate production with consistent profitability. This achievement represents a significant step towards the large-scale practical application of sustainable urea electrosynthesis.}, archive = {J_ANGEW}, author = {Jia-Yuan Li and Yue-Fei Li and Lin-Sen Li and Zhao Jiang and Yu Chen and Bao Yu Xia}, doi = {10.1002/anie.202421266}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421266}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote carbon monoxide spillover improves tandem urea electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Bottom-up strategy to enhance long-range order of Poly(Heptazine imide) nanorods for efficient photocatalytic CO2 methanation. ANGEW, 64(10), e202421263. (www)

  @article{ , abstract = {Poly(heptazine imide) (PHI), one of the crystalline or long-range ordered allotropes of polymeric carbon nitride, is a promising polymeric photocatalyst; however, preparation of highly crystalline PHI remains a challenge. Herein, through a bottom-up strategy involving repair of structural defects and increase of specific surface area of melon precursor, we prepared PHI nanorods with dramatically improved long-range order. The resulting PHI exhibited a shift of product selectivity in CO 2 photoreduction from CO to CH 4 with a high methanation activity in contrast to the pristine PHI with relatively low long-range order. The improvement of long-range order for PHI remarkably enhanced the separation efficiency and transfer kinetics of photogenerated charges as well as the adsorption for *CO intermediate. This study revealed the relationship between the precursor structure and PHI crystal growth in ionothermal synthesis, and also showcased the great potential of highly crystalline PHI in artificial photosynthesis.}, archive = {J_ANGEW}, author = {Jiaming Wu and Keyan Li and Bing Zhou and Rui Li and Siyang Yan and Jiaxu Liu and Hainan Shi and Chunshan Song and Xinwen Guo}, doi = {10.1002/anie.202421263}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421263}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bottom-up strategy to enhance long-range order of Poly(Heptazine imide) nanorods for efficient photocatalytic CO2 methanation}, volume = {64}, year = {2025}, }
• (2025). Sequential infiltration synthesis of cadmium sulfide discrete atom clusters. ANGEW, 64(10), e202421259. (www)

  @article{ , abstract = {Exposure of soft material templates to alternating volatile chemical precursors can produce inorganic deposition within the permeable template (e.g. a polymer thin film) in a process akin to atomic layer deposition (ALD). While such sequential infiltration synthesis (SIS) processes have now been demonstrated for many metal oxides, we report an SIS process for a transition metal sulfide – CdS. Gas phase dimethyl cadmium and hydrogen sulfide precursors infiltrated into poly(4-vinylpyridine) thin films result in the 3D-nucleation of clusters consistent with a cubane-type Cd 4 S 4 core that are variably terminated with methyl, thiol and hydroxy capping ligands. First principles models and simulation of few-atom Cd-based clusters are consistent with electronic and vibrational spectroscopy and grazing-incidence total X-ray scattering measurements of 3D-cluster-arrays synthesized at 80 °C. The direct synthesis of few-atom transition metal sulfide clusters within polymer thin films will provide a versatile new route to precision architectures for light-absorbing materials including solar energy harvesting and conversion applications.}, archive = {J_ANGEW}, author = {Nuwanthaka P. Jayaweera and Shana Havenridge and Ashley R. Bielinski and Kihoon Kim and Niklas B. Thompson and Justin M. Hoffman and Amelia M. Wheaton and Prasenjit Sarkar and Rajesh Pathak and Jeffrey W. Elam and Cong Liu and Karen L. Mulfort and Alex B. F. Martinson}, doi = {10.1002/anie.202421259}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sequential infiltration synthesis of cadmium sulfide discrete atom clusters}, volume = {64}, year = {2025}, }
• (2025). Heterocoupling two similar benzyl radicals by dual Photoredox/Cobalt catalysis. ANGEW, 64(10), e202421256. (www)

  @article{ , abstract = {Transition-metal-regulated radical cross coupling enables the selective bonding of two distinct transient radicals, whereas the catalytic method for sorting two almost identical transient radicals, especially similar benzyl radicals, is still rare. Herein, we show that leveraging dual photoredox/cobalt catalysis can selectively couple two similar benzyl radicals. Using easily accessible methylarenes and phenylacetates (benzyl N -hydroxyphthalimide (NHPI) esters) as benzyl radical sources, a range of unsymmetrical 1,2-diarylethane classes via the 1°–1°, 1°–2°, 1°–3°, 2°–2°, 2°–3° and 3°–3° couplings were obtained with broad functional group tolerance. Besides the photochemical continuous flow synthesis, the one-pot procedure that directly uses phenylacetic acids and NHPI as the starting materials to avoid the pre-preparation of benzyl NHPI esters for the gram-scale synthesis is also feasible and affords good yields, showcasing the synthetic utility of our protocol.}, archive = {J_ANGEW}, author = {Wei Yang and Zhenyan Zhao and Yu Lan and Zhou Dong and Ruiying Chang and Yihang Bai and Shihan Liu and Shi-Jun Li and Linbin Niu}, doi = {10.1002/anie.202421256}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421256}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterocoupling two similar benzyl radicals by dual Photoredox/Cobalt catalysis}, volume = {64}, year = {2025}, }
• (2025). Rapid and scalable preparation of high-crystalline carboxyl-functionalized covalent triazine frameworks via friedel-crafts reaction. ANGEW, 64(10), e202421251. (www)

  @article{ , abstract = {The Friedel-Crafts reaction has been extensively applied to the preparation of various porous organic polymers because of its simple operation and abundant building blocks. However, due to its poor reversibility and excessive random reactive sites, the synthesis of crystalline organic polymers/frameworks by Friedel-Crafts reaction has never been realized so far. Herein, we develop a molecular confined Friedel-Crafts reaction strategy to achieve rapid preparation (within only 30 minutes) of highly crystalline covalent triazine frameworks (CTFs) with tailorable functionality for the first time. Theoretical calculations and detailed experiments revealed the critical role of carboxyl groups in aromatic benzene monomer during the CTFs crystallization, which can not only effectively cause a suitable activation barrier for the electrophilic attack of 2,4,6-trichloro-1,3,5-triazine through their electron-withdrawing properties, but also introduce anchoring effects (molecular confinement effects) to facilitate the ordered polymerization at specific sites in 2D planar direction. Benefiting from the convenient synthetic route and low-cost raw materials, we could unprecedentedly realize the kilogram-scale fabrication of carboxyl-functionalized high-crystalline CTFs. Moreover, thanks to the hydrophilic and ionizable properties of carboxyl groups, the obtained functionalized CTFs exhibited excellent aqueous dispersibility and superior solution processability.}, archive = {J_ANGEW}, author = {Lei Zhang and Tian Sun and Zhao Zhang and Ziyue Zhang and Yuxi Xu}, doi = {10.1002/anie.202421251}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421251}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid and scalable preparation of high-crystalline carboxyl-functionalized covalent triazine frameworks via friedel-crafts reaction}, volume = {64}, year = {2025}, }
• (2025). Direct synthesis of topology-controlled BODIPY and CO2-based zirconium metal-organic frameworks for efficient photocatalytic CO2 reduction. ANGEW, 64(10), e202421248. (www)

  @article{ , abstract = {Boron dipyrromethene (BODIPY)-based zirconium metal–organic frameworks (Zr-MOFs) possess strong light-harvesting capabilities and great potential for artificial photosynthesis without the use of sacrificial reagents. However, their direct preparation has not yet been achieved due to challenges in synthesizing suitable ligands. Herein, we reported the first successful direct synthesis of BODIPY-based Zr-MOFs, utilizing CO 2 as a feedstock. By controlling synthetic conditions, we successfully obtained two distinct Zr-MOFs. The first, CO 2 -Zr 6 -DEPB, exhibits a face-centered cubic ( fcu ) topology based on a Zr 6 ( μ 3 -O) 4 ( μ 3 -OH) 4 node, while the second, CO 2 -Zr 12 -DEPB, features a hexagonal closed packed ( hcp ) topology, structured around a Zr 12 ( μ 3 -O) 8 ( μ 3 -OH) 8 ( μ 2 -OH) 6 node. Both MOFs demonstrated excellent crystallinity, as verified through powder X-ray diffraction and high-resolution transmission electron microscopy analyses. These MOF catalysts displayed suitable photocatalytic redox potentials for the reduction of CO 2 to CO using H 2 O as the electron donor in the absence of co-catalyst or toxic sacrificial reagent. Under light irradiation, CO 2 -Zr 12 -DEPB and CO 2 -Zr 6 -DEPB offered high CO yields of 16.72 and 13.91 μmol g −1 h −1 , respectively, with nearly 100 % selectivity. CO 2 uptake and photoelectrochemical experiments revealed key insights into the mechanisms driving the different catalytic activities of the two MOFs. These BODIPY and CO 2 -based, light-responsive Zr-MOFs represent a promising platform for the development of efficient photocatalysts.}, archive = {J_ANGEW}, author = {Bo Song and Wentao Song and Yuhang Liang and Yong Liu and Bowen Li and He Li and Liang Zhang and Yanhang Ma and Ruquan Ye and Ben Zhong Tang and Dan Zhao and Yi Zhou and Bin Liu}, doi = {10.1002/anie.202421248}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421248}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct synthesis of topology-controlled BODIPY and CO2-based zirconium metal-organic frameworks for efficient photocatalytic CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Access to quaternary-substituted cyclobutylsilanes by ring opening of arylbicyclobutanes with silyllithium reagents. ANGEW, 64(10), e202421235. (www)

  @article{ , abstract = {Disclosed herein is the reaction of silyllithium reagents with quaternary-substituted arylbicyclobutanes to diastereoselectively form polysubstituted cyclobutylsilanes by C−C bond cleavage. The bicyclobutanes are generated in situ, by lithium-halogen exchange, from readily accessible (bromomethyl)iodocyclopropane precursors, rendering this a one-pot transformation. The trapping of a generated cyclobutyllithium intermediate with an electrophile was also demonstrated, providing a cyclobutane product with vicinal quaternary stereocenters. The utility of the cyclobutylsilane products was showcased by Tamao−Fleming oxidation to prepare a quaternary-substituted cyclobutanol.}, archive = {J_ANGEW}, author = {Zachary P. Sercel and Ilan Marek}, doi = {10.1002/anie.202421235}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421235}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Access to quaternary-substituted cyclobutylsilanes by ring opening of arylbicyclobutanes with silyllithium reagents}, volume = {64}, year = {2025}, }
• (2025). Initiator-free thiol-aldehyde photo polycondensation. ANGEW, 64(10), e202421231. (www)

  @article{ , abstract = {Traditional photopolymerizations generally require an initiator for initiating the polymerization while few cases have created degradable chemical bonds. Moreover, the migration instability and cytotoxicity of photo initiators are posing issues to human health and the environment. In this work, we discovered an initiator-free photo polycondensation system (IFPPC) between polymercaptans and aldehyde monomers, producing elastic and high strength plastic materials with exchangeable and degradable dithioacetal groups. IFPPC proceeds through a radical mechanism and is applicable in producing linear polymers and crosslinked networks. Nano-composites can also be obtained via an organic solvent-free Pickering emulsion polymerization using cellulose nanofibers as the stabilizer. The dithioacetal groups afford excellent stability under hydrolytic conditions and repeated thermal processing of cross-linked polymers, while their cleavage in aqueous solution of salts (silver nitrate, zinc iodide, copper bromide, etc.) results in fast degradation for recovering the aldehyde monomer. This is a successful demonstration of producing recyclable and degradable plastics through photo irradiation while avoiding the problematic issues of photo initiators.}, archive = {J_ANGEW}, author = {Wangmao Tian and Jie Wang and Yu Jin and Yaming Cheng and Kangle Yan and Chengcheng Hu and Cheng Chen and Baoxia Wang and Zhongkai Wang and Liang Yuan}, doi = {10.1002/anie.202421231}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421231}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Initiator-free thiol-aldehyde photo polycondensation}, volume = {64}, year = {2025}, }
• (2025). Bionic hollow porous carbon nanofibers for energy-dense and rapid zinc ion storage. ANGEW, 64(10), e202421230. (www)

  @article{ , abstract = {Suboptimal spatial utilization and inefficient access to internal porosity preclude porous carbon cathodes from delivering high energy density in zinc-ion hybrid capacitors (ZIHCs). Inspired by the function of capillaries in biological systems, this study proposes a facile coordination-pyrolysis method to fabricate thin-walled hollow carbon nanofibers (CNFs) with optimized pore structure and surface functional groups for ZIHCs. The capillary-like CNFs maximize the electrode/electrolyte interface area, facilitating the optimal utilization of energy storage sites. The precision-engineered pore sizes in the fiber walls are specifically tailored to accommodate solvated [Zn(H 2 O) 6 ] 2+ , thus enhancing ion storage capacity and supporting accelerated transport kinetics. The resultant ZIHCs achieve a battery-grade energy density of 132.8 Wh kg −1 (based on active material), remarkable stability (98.7 % retention after 80,000 cycles at 10 A g −1 ), along with practically high areal capacities. Combined in situ/ ex situ spectroscopic characterizations, kinetic analyses, and theoretical calculations revealed that the superior energy storage performance arises from the advantageous microstructure of the biomimetic CNFs and the reversible physical/chemical adsorption process. This investigation offers a novel strategy for designing high-efficiency zinc ion storage carbon nanomaterials and provides insights into the cathodic storage mechanisms essential for advancing ZIHCs.}, archive = {J_ANGEW}, author = {Guangjie Yang and Qian Zhang and Chenweijia He and Zhe Gong and Zhenlu Liu and Jian Song and Shaohua Jiang and Jingquan Han and Haoqi Yang and Xue Li and Zengxia Pei and Shuijian He}, doi = {10.1002/anie.202421230}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421230}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bionic hollow porous carbon nanofibers for energy-dense and rapid zinc ion storage}, volume = {64}, year = {2025}, }
• (2025). Employing octahedral net charge descriptors for designing high-performance aqueous proton batteries. ANGEW, 64(10), e202421224. (www)

  @article{ , abstract = {Recently, aqueous proton batteries have shown promise for electrochemical energy storage using MXene electrodes. However, designing high-performance MXene proton batteries remains challenging due to the inevitable hydrogen evolution reaction (HER), the vast chemical composition space of MXene, and the unclear proton transport mechanism. To tackle these challenges, we established a general descriptor based on structural units of MXenes, termed the octahedral net charge descriptor ( Q oct ). This descriptor correlates well with HER activity, capacity, and proton transport performance. Based on the descriptor, prediction reveals a dual-proton storage mechanism per site in N-functionalized MXene. Meanwhile, the accuracy of the descriptor is verified across a broader MXene chemical space. Additionally, the kinetic process shows the topological transformation energy barrier of the interfacial solution is profoundly influenced by Q oct , thereby impacting the proton transfer performance. This universal descriptor originates from the different electron filling states on the molecular orbitals of the octahedron. Overall, this work provides an efficient strategy for designing MXene proton batteries and can be extended to other battery and catalysis fields.}, archive = {J_ANGEW}, author = {Jun Zhao and Ninggui Ma and Yuhang Wang and Zhaowei Wang and Tairan Wang and Bochun Liang and Yaqin Zhang and Jian Han and Chunyi Zhi and Jun Fan}, doi = {10.1002/anie.202421224}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421224}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Employing octahedral net charge descriptors for designing high-performance aqueous proton batteries}, volume = {64}, year = {2025}, }
• (2025). Synthesis of Iron(IV) alkynylide complexes and their reactivity to form 1,3-diynes. ANGEW, 64(10), e202421222. (www)

  @article{ , abstract = {The isolation of thermally unstable and highly reactive organoiron(IV) complexes is a challenge for synthetic chemists. In particular, the number of examples where the C-based ligand is not part of the chelating ligand remains scarce. These compounds are of interest because they could pave the way to designing catalytic cycles of bond forming reactions proceeding via organoiron(IV) intermediates. Herein, we report the synthesis and characterization, including single-crystal X-ray diffraction, of a family of alkynylferrates(III) and Fe(IV) alkynylide complexes. The alkynylferrates(III) are formed by transmetalation of the Fe(III) precursor [(N 3 N’)Fe III ] (N 3 N’ 3− is tris(N- tert -butyldimethylsilyl-2-amidoethyl)amine) with lithium alkynylides, and their further one-electron oxidation enables the synthesis of the corresponding Fe(IV) alkynylides. The electronic structure of this family of organometallic Fe(III) and Fe(IV) complexes has been thoroughly investigated by spectroscopic methods (EPR, NMR, 57 Fe Mössbauer, X-Ray absorption (XAS) and emission (XES) spectroscopies) and theoretical calculations. While alkynylferrates(III) are sluggish to engage into C−C bond forming processes, the Fe(IV) alkynylides react to afford 1,3-diynes at room temperature. A bimolecular reductive elimination from a bimetallic Fe(IV) intermediate to form the 1,3-diynes is proposed based on the mechanistic investigations performed.}, archive = {J_ANGEW}, author = {Charafa Souilah and Sergio A. V. Jannuzzi and Felix J. Becker and Derya Demirbas and Daniel Jenisch and Sergei Ivlev and Xiulan Xie and Sergey Peredkov and Crispin Lichtenberg and Serena DeBeer and Alicia Casitas}, doi = {10.1002/anie.202421222}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421222}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of Iron(IV) alkynylide complexes and their reactivity to form 1,3-diynes}, volume = {64}, year = {2025}, }
• (2025). Highly durable rh single atom catalyst modulated by surface defects on fe-ce oxide solid solution. ANGEW, 64(10), e202421218. (www)

  @article{ , abstract = {Forming defect sites on catalyst supports and immobilizing precious metal atoms at these sites offers an efficient approach for preparing single-atom catalysts. In this study, we employed an Fe−Ce oxide solid solution (FC), which has surface oxygen that reduces more readily than that of ceria, to anchor Rh single atoms (Rh 1 ). When utilized in the selective catalytic reduction of NO with CO (CO-SCR), Rh 1 /FC reduced at 500 °C—characterized by less oxidic Rh state induced by an oxygen-deficient coordination—exhibited superior activity and durability compared to Rh 1 /ceria and Rh 1 /FC reduced at 300 °C. This Rh single-atom structure was sustained after 100 hours of CO-SCR at 400 °C. Reaction intermediates formed on the catalyst surface were analyzed using in situ diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) under NO and CO flow conditions. Additionally, the catalyst structure and the CO-SCR reaction mechanism were investigated using density functional theory (DFT). While Rh atoms located near surface Fe sites were found to be thermodynamically most stable, both NO and CO preferentially adsorbed on Rh sites. Fe plays a role in stabilizing Rh sites and facilitating oxygen transfer. This work provides valuable insights into the design of highly active and durable single-atom catalysts.}, archive = {J_ANGEW}, author = {Gunjoo Kim and Seokhyun Choung and Jae-eon Hwang and Yunji Choi and Seungeun Kim and Dongjae Shin and Jeong Woo Han and Hyunjoo Lee}, doi = {10.1002/anie.202421218}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421218}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly durable rh single atom catalyst modulated by surface defects on fe-ce oxide solid solution}, volume = {64}, year = {2025}, }
• (2025). A three-tiered golf anode towards ultralong-life Zn−Mn aqueous batteries. ANGEW, 64(10), e202421217. (www)

  @article{ , abstract = {Zn−Mn aqueous batteries (ZMABs) are widely recognized as a promising candidate for large-scale energy storage due to their cost-effectiveness, high safety and environmental friendliness. However, the practical application of ZMABs is hindered by inherent electrical contact loss, hydrogen evolution and dendrite growth on traditional anodes. Here, a three-tiered golf anode with high conductivity is developed to simultaneously enhance the reversibility of Zn and Mn metals. The three-tiered golf anode is achieved by inner zinc powder, intermediate carbon and outer bismuth layer, which can effectively enhance the Gibbs free energy and mitigate the volume change of the anode, thus enabling stable Zn−Mn cycling. As a proof of concept, Zn−Mn full cells (coupled to CNT@MnO 2 ) achieve an ultralong cycle life with 94.6 % capacity retention at 2 A g −1 after 16,000 cycles. This study presents valuable insights into the structural design of anodes aimed at enhancing the stability and durability of ZMABs.}, archive = {J_ANGEW}, author = {Qiang Hu and Xinrui Wang and Jiuzhi Cui and Jiabing Hou and Xingquan Liu and Jia-Lin Yang and Zhen-Yi Gu and Jingxin Zhao and Bingang Xu and Xing-Long Wu}, doi = {10.1002/anie.202421217}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421217}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A three-tiered golf anode towards ultralong-life Zn−Mn aqueous batteries}, volume = {64}, year = {2025}, }
• (2025). Electrolyte anions suppress hydrogen generation in electrochemical CO reduction on cu. ANGEW, 64(10), e202421196. (www)

  @article{ , abstract = {In this study, we employed electrochemical-mass spectrometry (EC-MS) to elucidate the role of halide anions in electrochemical CO 2 and CO reduction. We found that the undesired hydrogen evolution reaction (HER) was significantly suppressed by the anion used. Specifically, the rates of H 2 production decreased in the order KF > KCl > KI, meaning that I − most strongly suppressed HER. Interestingly, CO reduction products showed an inverse relationship to HER, with KI leading to the highest rate of CO reduction. By pairing our experimental findings with classical molecular dynamics simulations, we propose a mechanism wherein halide anions influence the dynamic interplay between CO reduction and HER by modulating the competition of H* and CO* for active sites on the Cu surface. We propose that this interaction is enabled by the interfacial concentration of K + being greater in the presence of F − than in I − . Our results highlight the need to more broadly consider the properties of ions at electrocatalytic interfaces and they point to thus far underappreciated avenues to optimize hydrocarbon production while suppressing hydrogen evolution.}, archive = {J_ANGEW}, author = {Lee Fuller and Gong Zhang and Seonmyeong Noh and Reid C. Van Lehn and Marcel Schreier}, doi = {10.1002/anie.202421196}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421196}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte anions suppress hydrogen generation in electrochemical CO reduction on cu}, volume = {64}, year = {2025}, }
• (2025). Enhanced electrochemiluminescence by knocking out gold active sites. ANGEW, 64(10), e202421185. (www)

  @article{ , abstract = {Electrochemiluminescence (ECL) of the conventional system of [Ru(bpy) 3 ] 2+ luminophore and amine-based coreactants is particularly inefficient on noble metal electrodes. This is due to the formation of a passivating oxide layer on the metal surface inhibiting the electro-oxidation of amines like tri- n -propylamine (TPrA) coreactant. Herein, we demonstrated the enhancement of ECL emission on gold surface by hydroxyl radicals attack that are chemically generated with Cu-Fenton reagent. These radicals selectively deactivate the gold active sites and knockout the metal surface asperities that counterintuitively led to an amplification of the ECL emission. Atomic force microscopy shows a massive smoothening of the surface. The electrochemical characterization proves that the involved ECL reaction mechanism switches from direct oxidation to catalytic route, where the kinetics of indirect TPrA oxidation is facilitated on deactivated gold surface. Besides, in situ smoothening of a rough electrode in presence of tandem [Ru(bpy) 3 ] 2+ /TPrA enables Cu 2+ sensing with good reliability and limit of detection. Such atomically smoothened and corrosion-resistant gold surface readily tuned the ECL reactivity and opened new directions on influence of topography and reactivity on ECL mechanisms, thus will be extremely useful for the future development of ECL imaging strategies and highly sensitive ECL sensors.}, archive = {J_ANGEW}, author = {Indhu Leka Kottaiveedu Sivakumar and Laurent Bouffier and Neso Sojic and Shanmugam Senthil Kumar}, doi = {10.1002/anie.202421185}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421185}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced electrochemiluminescence by knocking out gold active sites}, volume = {64}, year = {2025}, }
• (2025). Photoswitchable topological regulation of covalent macrocycles, molecular recognition, and interlocked structures. ANGEW, 64(10), e202421175. (www)

  @article{ , abstract = {Macrocycles represent one important class of functional molecules, and dynamic macrocycles with the potential of cleavability, adaptability, and topological conversion are challenging. Herein we report photoswitchable allosteric and topological control of dynamic covalent macrocycles and further the use in guest binding and mechanically interlocked molecules. The manipulation of competing ring-chain equilibria and bond formation/scission within reaction systems enabled light-induced structural regulation over dithioacetal and thioacetal dynamic bonds, accordingly realizing bidirectional switching between crown ether-like covalent macrocycles and their linear counterparts. The on-demand photoswitchable topological transformation of macrocycles further allowed guest recognition/release exhibiting controllable binding affinity and selectivity. To showcase the capability light-triggered assembly/disassembly of diverse mechanically interlocked structures, such as rotaxanes and catenanes, was achieved. The realization of photoswitchable topological conversion of covalent macrocycles, which has been rarely reported before, demonstrates the potential of light-triggered reactivity control and structural reconfiguration for enhanced complexity and sophisticated function. The strategies and results should be appealing to endeavors in molecular recognition, dynamic assemblies, molecular machines, and intelligent materials.}, archive = {J_ANGEW}, author = {Hanwei Lu and Hebo Ye and Jiafan Xin and Lei You}, doi = {10.1002/anie.202421175}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421175}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoswitchable topological regulation of covalent macrocycles, molecular recognition, and interlocked structures}, volume = {64}, year = {2025}, }
• (2025). In situ polymerization induced seed-root anchoring structure for enhancing stability and efficiency in perovskite solar modules. ANGEW, 64(10), e202421174. (www)

  @article{ , abstract = {The escape of organic cations over time from defective perovskite interface leads to non-stoichiometric terminals, significantly affecting the stability of perovskite solar cells (PSCs). How to stabilize the interface composition under environmental stress remains a grand challenge. To address this issue, we utilize thiol-functionalized particles as a “seed” and conduct in situ polymerization of 2,2,3,4,4,4-hexafluorobutyl methacrylate (HFMA) as a “root” at the bottom of the perovskite layer. In this process, the thiol group acts as the initiation site for the polymerization of HFMA, while the fluorine groups in HFMA firmly anchor the organic cations of the perovskite through multiple hydrogen bonds. This strategy resembles how seeds take root in soil to prevent soil erosion. This bionic seed-rooting structure effectively stabilizes the stoichiometry of the perovskite, thus suppressing the escape of organic cations. As a result, the perovskite films with seed-rooting structures exhibit enhanced stability under harsh vacuum thermal conditions (150 °C, <10 Pa). The resulting PCS achieves an efficiency of 25.64 % and a 22.4 cm 2 module efficiency of 22.61 %. After 1300 hours of 1-sun illumination at 85 % relative humidity and 65 °C (ISOS−L-3 protocol), the perovskite solar module maintains 90 % of its initial efficiency.}, archive = {J_ANGEW}, author = {Sibo Li and Xiaowei Xu and Xin Wang and Nuanshan Huang and Jun Fang and Dongxu Lin and Yueyue Shao and Jia Zhou and Aung Ko Ko Kyaw and Sisi He and Longbin Qiu}, doi = {10.1002/anie.202421174}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421174}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ polymerization induced seed-root anchoring structure for enhancing stability and efficiency in perovskite solar modules}, volume = {64}, year = {2025}, }
• (2025). Discovering cell-targeting ligands and cell-surface receptors by selection of DNA-encoded chemical libraries against cancer cells without predefined targets. ANGEW, 64(10), e202421172. (www)

  @article{ , abstract = {Small molecules that can bind to specific cells have broad application in cancer diagnosis and treatment. Screening large chemical libraries against live cells is an effective strategy for discovering cell-targeting ligands. The DNA-encoded chemical library (DEL or DECL) technology has emerged as a robust tool in drug discovery and has been successfully utilized in identifying ligands for biological targets. However, nearly all DEL selections have predefined targets, while target-agnostic DEL selections interrogating the entire cell surface remain underexplored. Herein, we systematically optimized a cell-based DEL selection method against cancer cells without predefined targets. A 104.96-million-member DEL was selected against MDA-MB-231 and MCF-7 breast cancer cells, representing high and low metastatic properties, respectively, which led to the identification of cell-specific small molecules. We further demonstrated cell-targeting applications of these ligands in cancer photodynamic therapy and targeted drug delivery. Finally, leveraging the DNA tag of DEL compounds, we identified α-enolase (ENO1) as the cell surface receptor of one of the ligands targeting the more aggressive MDA-MB-231 cells. Overall, this work offers an efficient approach for discovering cell-targeting small molecule ligands by using DELs and demonstrates that DELs can be a useful tool to identify specific surface receptors on cancer cells.}, archive = {J_ANGEW}, author = {Yuhan Gui and Rui Hou and Yuchen Huang and Yu Zhou and Shihao Liu and Ling Meng and Ying Li and Fong Sang Lam and Ruoyun Ding and Yan Cao and Gang Li and Xiaojie Lu and Xiaoyu Li}, doi = {10.1002/anie.202421172}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421172}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Discovering cell-targeting ligands and cell-surface receptors by selection of DNA-encoded chemical libraries against cancer cells without predefined targets}, volume = {64}, year = {2025}, }
• (2025). Atomically dispersed fe2 and ni sites for efficient and durable oxygen electrocatalysis. ANGEW, 64(10), e202421168. (www)

  @article{ , abstract = {Developing highly efficient, cost-effective, and robust electrocatalysts for the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) is paramount for the large-scale commercialization of renewable fuel cells and rechargeable metal-air batteries. Herein, a new ternary-atom catalyst that is composed of paired Fe sites and single Ni sites (as Fe 2 −N 6 and Ni−N 4 ) coordinated onto hollow nitrogen-doped carbon microspheres is developed. The as-synthesized catalyst exhibits remarkable activities toward both the ORR and OER in alkaline media, with superior performances to those of the control materials that contain only Fe 2 −N 6 or Ni−N 4 sites. Density functional theory calculations and in situ infrared (IR) spectroscopic studies clearly reveal that the Fe 2 −N 6 centers are the active sites for both ORR and OER, and their electrocatalytic activities are synergistically enhanced through optimization of their d-band centers by the Ni−N 4 sites. This ternary-atom catalyst can potentially be a promising, alternative, sustainable catalyst to commercially used Pt- and Ru-based catalysts to drive both the ORR and the OER in rechargeable zinc-air batteries and other related applications.}, archive = {J_ANGEW}, author = {Guiyuan Yang and Meihong Fan and Qing Liang and Xingquan He and Wei Zhang and Tewodros Asefa}, doi = {10.1002/anie.202421168}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421168}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomically dispersed fe2 and ni sites for efficient and durable oxygen electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). 4D printing of liquid crystal emulsions for smart structures with multiple functionalities. ANGEW, 64(10), e202421162. (www)

  @article{ , abstract = {3D printing, and more recently 4D printing, has emerged as a transformative technology for fabricating structures with complex geometries and responsive properties. However, employing functional colloidal solutions as inks for printing remains unexplored. In this work, we present a novel and versatile 4D printing approach for fabricating functional and complex-shaped objects using polymerizable liquid crystal (LC) emulsion droplets. Leveraging a digital light processing (DLP) 3D printing technique, we achieve rapid production of intricate 3D geometries with high resolution. The printed structures retain the LC ordering from the precursor droplets, imparting the final objects with shape memory properties, including shape fixation and recovery upon heating or light exposure. Light-responsive behavior is introduced post-printing by embedding an azo dye into the 3D structures. Additionally, we explore the potential to create intrinsically porous 3D structures by selectively removing non-reactive components from the printed geometries, adding an extra level of functionality to the printed objects. Furthermore, we incorporate chiral nematic LCs into the emulsion droplets, producing 3D objects with tunable reflective properties. To our knowledge, this is the first example of DLP 3D printing with emulsions, offering an effective and versatile pathway for developing 4D-printed materials with potential applications in optics, robotics, microfluidics, and biomedicine.}, archive = {J_ANGEW}, author = {Alberto Concellón and Philipp Mainik and Clara Vazquez-Martel and Cristina Álvarez-Solana and Eva Blasco}, doi = {10.1002/anie.202421162}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {4D printing of liquid crystal emulsions for smart structures with multiple functionalities}, volume = {64}, year = {2025}, }
• (2025). High-valent cobalt-difluoride in oxidative fluorination of saturated hydrocarbons. ANGEW, 64(10), e202421157. (www)

  @article{ , abstract = {The heme paradigm where Fe=O acts as the C−H oxidant and Fe−OH rebounds with the formed carbon-centered radical guides the design of the prototypical synthetic hydroxylation catalyst. We are exploring methods to evolve beyond the metal-oxo oxidant and hydroxide rebound, to incorporate a wider array of functional group. We have demonstrated the application of Co II (OTf) 2 (10 mol% catalyst; OTf=trimfluoromethanesulfonate) in combination with polydentate N-donor ligands (e. g. BPMEN=N,N′-dimethyl-N,N′-bis(pyrid-2-ylmethyl)ethane-1,2-diamine) and Selectfluor in the oxidative fluorination of saturated hydrocarbons in high yields. The addition of CsF to the reaction mixture induced near-quantitative yields of fluorinated saturated hydrocarbons (>90 % yield of fluorinated product). For 1-hydroxy, 1-acetyl, 1-carboxy-, and 1-acetamido-adamantane, we demonstrated selective fluorination at the 3-position. We propose two mechanisms for the Co II -catalyzed reaction: either (i) an N-radical, derived from Selectfluor, acted as the C−H oxidant followed by radical rebound with Co III −F; or (ii) a Co IV −(F) 2 species was the C−H oxidant followed by radical rebound with Co III −F. Our combined spectroscopic, kinetic, and chemical trapping evidence suggested that an N-radical was not the active oxidant. We concluded that a Co IV −(F) 2 species was the likely active oxidant and Co III −F was the likely F-atom donor to a carbon centered radical producing a C−F bond.}, archive = {J_ANGEW}, author = {Agnideep Das and Brendan Twamley and Oscar R. Kelly and Chakadola Panda and Paul Richardson and Aidan R. McDonald}, doi = {10.1002/anie.202421157}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421157}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-valent cobalt-difluoride in oxidative fluorination of saturated hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). Synergistic pathways in PLA breakdown and PTMC formation: A one-pot eutectic-driven recycling mechanism. ANGEW, 64(10), e202421150. (www)

  @article{ , abstract = {This study introduces a novel one-pot strategy for the chemical valorization of poly(lactic acid) (PLA), coupling its base-catalyzed depolymerization with the ring-opening polymerization (ROP) of trimethylene carbonate (TMC). The process exploits an eutectic mixture of lactide (LA) and TMC, which lowers the thermal input required for PLA degradation. Using potassium aryloxide (KOAr t Bu ) as a bifunctional catalyst, the PLA is first quickly hydrolyzed into oligomers or lactic acid, which subsequently initiate the slower polymerization of TMC. Notably, this transformation operates in the presence of residual water, eliminating the need for tedious drying steps. The method achieves selective PLA breakdown conversion and produces (oligo)lactic acid end-capped poly(trimethylene carbonate) (PTMC) with tunable molar mass, depending on water content.}, archive = {J_ANGEW}, author = {Sébastien Moins and Olivier Coulembier}, doi = {10.1002/anie.202421150}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421150}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic pathways in PLA breakdown and PTMC formation: A one-pot eutectic-driven recycling mechanism}, volume = {64}, year = {2025}, }
• (2025). Selective electroreduction of CO2 to CO over ultrawide potential window via implanting active site with long-range p regulation on periodic pores. ANGEW, 64(10), e202421149. (www)

  @article{ , abstract = {Electroreduction of CO 2 to CO represents a highly promising way for artificial carbon cycling, but obtaining high selectivity over a wide potential window remains a challenge due to the sluggish CO generation and diffusion kinetics. Here we report an integration of long-range P modified bismuth atomic site on an ordered macroporous carbon skeleton with mesoporous “wall” (MW-BiN 3 -POMC) for efficient electroreduction of CO 2 . In-depth in situ investigations with theoretical computations reveal that the incorporation of long-range P atom is able to strengthen the orbital interaction between the C 2p of CO 2 and Bi 6p, thereby establishing an electronic transport bridge for the activation of CO 2 molecule. Additionally, the ordered macropore with mesoporous wall effectively facilitates the diffusion of CO. As a result, MW-BiN 3 -POMC exhibits an ultrawide potential window of 1000 mV for high CO selectivity (>90 %) and a maximal CO partial current density of 414 mA cm −2 . Moreover, MW-BiN 3 -POMC can also be employed as the cathode to integrate the solar-driven electrolytic cell (anode of Co 3 O 4 -OMC) toward CO 2 reduction coupled with 5-hydroxymethylfurfural oxidation to simultaneously yield CO and 2,5-furandicarboxylic acid.}, archive = {J_ANGEW}, author = {Datong Chen and Fengliang Wang and Yang Liu and Wenyuan Lyu and Xin Zhao and Ruiqi Fang and Liyu Chen and Yingwei Li}, doi = {10.1002/anie.202421149}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421149}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective electroreduction of CO2 to CO over ultrawide potential window via implanting active site with long-range p regulation on periodic pores}, volume = {64}, year = {2025}, }
• (2025). Chiral Pd2L4 capsules from readily accessible tröger's base ligands inducing circular dichroism on fullerenes c60 and c70. ANGEW, 64(10), e202421137. (www)

  @article{ , abstract = {The induction of chirality on pristine fullerenes through non-covalent embedding in an asymmetric nano-confinement has only been rarely reported. Bringing molecules with such a unique electronic structure and broad application range into a chiral environment is particularly appealing for the development of chiroptical materials, enantioselective photoredox catalysts and systems showing chirality-induced spin selectivity (CISS). In this study, we report the formation of a chiral, configurationally stable Pd 2 L 4 capsule assembled from a C 2 -symmetric, ‘ribbon-shaped’ ligand with a Tröger's base naphthalimide (TbNaps) backbone, easily synthesized in three steps from commercially available compounds. Embedding chirality directly into the ligand backbone ensures a relatively lightweight receptor design whose aromatic panels create a strongly shielded inner cavity of about 700 Å 3 volume. Fullerenes C 60 and C 70 , as well as a pair of corannulenes, can be bound in acetonitrile (where unsubstituted fullerenes are insoluble) and X-ray structures of host-guest complexes were obtained. Tight interactions between the chiral host and the fullerene guests leads to the induction of a circular dichroism (CD) on the characteristic absorption bands of the forbidden π–π* transitions of the fullerenes, backed up by sTDA TD-DFT calculations and detailed investigation of the electronic excited states.}, archive = {J_ANGEW}, author = {Elie Benchimol and Helen M. O'Connor and Björn Schmidt and Nicola Bogo and Julian J. Holstein and June I. Lovitt and Sankarasekaran Shanmugaraju and Christopher J. Stein and Thorfinnur Gunnlaugsson and Guido H. Clever}, doi = {10.1002/anie.202421137}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421137}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral Pd2L4 capsules from readily accessible tröger's base ligands inducing circular dichroism on fullerenes c60 and c70}, volume = {64}, year = {2025}, }
• (2025). High-nuclearity polyoxometalate-based Metal–Organic frameworks for photocatalytic oxidative cleavage of C−C bond. ANGEW, 64(10), e202421132. (www)

  @article{ , abstract = {High-nuclearity polyoxometalate (POM) clusters are attractive building blocks (BBs) for the synthesis of metal–organic frameworks (MOFs) due to their high connectivity and inherently multiple metal centers as functional sites. This work demonstrates a strategy of step-wise growth on ring-shaped [P 8 W 48 O 184 ] 40− precursor, which produced two new high-nuclearity polyoxotungstates, a half-closed [H 16 P 8 W 58 O 218 ] 32− {W 58 } and a fully-closed [H 16 P 8 W 64 O 236 ] 32− {W 64 }. By in situ synthesis, unique MOFs of copper triazole-benzoic acid (HL) complexes incorporating the negatively-charged {W 58 } and {W 64 } as nodes, {Cu 11 (HL) 9 W 58 } HNPOMOF-1 and {Cu 9 (HL) 9 W 64 } HNPOMOF-2 , were constructed by delicately tuning the reaction conditions, mainly solution pH, which controls the formation of {W 58 } and {W 64 }, and at the same time the protonation of triazole-benzoic acid ligand thus its coordination mode to copper ion that creates the highest nuclearity POM-derived MOFs reported to date. HNPOMOF-1 features 3D framework possessing cage-like cavities filled with exposed carboxyl groups, while the inherent 2D layer-like HNPOMOF-2 allows for facile exfoliation into ultrathin nanosheets, and the resulted HNPOMOF-2 NS exhibits superior activity towards photocatalytic oxidative cleavage of C−C bond for a series of lignin models. This work not only provides a strategy to build high-nuclearity POM cluster-based frameworks, but also demonstrates their great potential as functional materials for green catalysis.}, archive = {J_ANGEW}, author = {Qixin Zhao and Yang Zeng and Zhiqiang Jiang and Zhenxuan Huang and De-Liang Long and Leroy Cronin and Weimin Xuan}, doi = {10.1002/anie.202421132}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421132}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-nuclearity polyoxometalate-based Metal–Organic frameworks for photocatalytic oxidative cleavage of C−C bond}, volume = {64}, year = {2025}, }
• (2025). Red room temperature phosphorescence from lignin. ANGEW, 64(10), e202421112. (www)

  @article{ , abstract = {Materials with red room-temperature phosphorescence (RTP) derived from sustainable resources are crucial but rarely reported. Here, we produced red RTP materials from lignin. Lignin was covalently modified with Upy (1-(6-isocyanatohexyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) urea) to obtain Lig-Upy. The Upy in the Lig-Upy promoted the interaction between the aromatic units of lignin and reduced energy gaps of these molecules. As a result, Lig-Upy exhibited red RTP centered at 625 nm with a lifetime of 24.2 ms. Moreover, the hydrogen bonding interactions in Lig-Upy varied when embedded into different matrices, such as polyvinyl alcohol (PVA) or sodium montmorillonite (MTM), inducing a change in RTP wavelength and lifetime. Utilizing these properties, Lig-Upy was used as building blocks for producing materials exhibiting time-dependent phosphorescent colors (TDPCs). Such TDPCs materials have exhibited great potential for visual decorations, information encryption and anti-counterfeiting logos for medicine bottles.}, archive = {J_ANGEW}, author = {Hongda Guo and Huanjie Cheng and Ruixia Liu and Xiaoxia Chen and Luyao Wang and Chenhui Yang and Shujun Li and Shouxin Liu and Jian Li and Qingjiang Pan and Tony D. James and Zhijun Chen}, doi = {10.1002/anie.202421112}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Red room temperature phosphorescence from lignin}, volume = {64}, year = {2025}, }
• (2025). 2,3: 6,7-naphthalenediimide-based chiral triangular macrocycle: Self-assembled helix, outer π-surface directed co-assembly and circularly polarized luminescence. ANGEW, 64(10), e202421108. (www)

  @article{ , abstract = {Here, we report the synthesis and self-assembly of a novel chiral 2,3 : 6,7-naphthalenediimide-based triangular macrocycle (NDI-Δ) and its chiroptical properties. The enantiomeric NDI-Δ is synthesized by condensation of ( RR ) or ( SS )-trans-1,2-cyclohexanediamine and 2,3,6,7-naphthalenetetracarboxylic 2,3 : 6,7-dianhydride, in which the chirality of the macrocycles is controlled by the diamine. With the rigid outer π-surface, the macrocycle exhibits unique chiroptical properties and self-assembly modes. The NDI-Δ shows circularly polarized luminescence (CPL) in solution and can self-assemble into helical structures with the inversion of CPL signal and the enhancement of | g lum |. Moreover, the NDI-Δ has a tailored electron-deficient outer π-surface, which can co-assemble with an electron-rich anthracene (AN) to form an intermolecular charge transfer (CT) complex, generating a yellow-green CT-CPL. Crystal structure analysis confirms that AN is mounted on the outer surface of NDI-Δ through π-π stacking and C−H π interactions. This work provides a critical example for the self-assembly of macrocycles into helical structures and outer π-surface directed CT complexes formation, opening up a new clue for designing chiral macrocycle-based chiroptical materials.}, archive = {J_ANGEW}, author = {Shengfu Wu and Xin Song and Jie Lu and Wenchao Hao and Minghua Liu}, doi = {10.1002/anie.202421108}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421108}, shortjournal = {Angew. Chem. Int. Edit.}, title = {2,3: 6,7-naphthalenediimide-based chiral triangular macrocycle: Self-assembled helix, outer π-surface directed co-assembly and circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). A bifunctional imidazolyl iodide mediator of electrolyte boosts cathode kinetics and anode stability towards low overpotential and long-life li-o2 batteries. ANGEW, 64(10), e202421107. (www)

  @article{ , abstract = {The addition of a redox mediator as soluble catalyst into electrolyte can effectively overcome the bottlenecks of poor energy efficiency and limited cyclability for Li-O 2 batteries caused by passivation of insulating discharge products and unfavorable byproducts. Herein we report a novel soluble catalyst of bifunctional imidazolyl iodide salt additive, 1,3-dimethylimidazolium iodide (DMII), to successfully construct highly efficient and durable Li-O 2 batteries. The anion I − can effectively promote the charge transport of Li 2 O 2 and accelerate the redox kinetics of oxygen reduction/oxygen evolution reactions on the cathode side, thereby significantly decreasing the charge/discharge overpotential. Simultaneously, the cation DMI + forms an ultrathin stably solid-electrolyte interphase film on Li metal, greatly inhibiting the shuttle effect of I − and improving the stability of anode. Using this DMII additive, our Li-O 2 batteries achieve an extremely low voltage of 0.52 V and ultra-long cycling stability over 960 h. Notably, up to 95.8 % of the Li 2 O 2 yield further proves the reversible generation/decomposition of Li 2 O 2 without the occurrence of side reactions. Both experimental and theoretical results disclose that DMII enables Li + easily solvated, testifying the dominance of the solution-induced reaction mechanism. This work provides the possibility to design the soluble catalysts towards high-performance Li-O 2 batteries.}, archive = {J_ANGEW}, author = {Jing Liu and Yuejiao Li and Yajun Ding and Lisha Wu and Jieqiong Qin and Tongle Chen and Caixia Meng and Feng Zhou and Xiangkun Ma and Zhong-Shuai Wu}, doi = {10.1002/anie.202421107}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421107}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bifunctional imidazolyl iodide mediator of electrolyte boosts cathode kinetics and anode stability towards low overpotential and long-life li-o2 batteries}, volume = {64}, year = {2025}, }
• (2025). An efficient ultra-narrowband yellow emitter based on a double-boron-embedded tetraazacyclophane. ANGEW, 64(10), e202421102. (www)

  @article{ , abstract = {Ultra-narrowband and highly modifiable multiple resonance thermally activated delayed fluorescence (MR-TADF) materials are crucial for realizing high-performance wide-color-gamut display applications. Despite progress, most MR-TADF emitters remain confined to blue and green wavelengths, with difficulties extending into longer wavelengths without significant spectral broadening, which compromises color purity in full-color organic light-emitting diode (OLED) displays. In this work, we present a novel tetraazacyclophane-based architecture embedding dual boron atoms to remarkedly enhance intramolecular charge transfer through the strategic positioning of boron and nitrogen atoms. This arrangement induces a substantial redshift while maintaining structural rigidity and molecular orbital symmetry, with a hole-electron central distance of 0 Å, allowing for ultra-narrowband emission. The resulting MR-TADF material, HBN , delivers yellow emission peaking at 572 nm (2.168 eV) with an impressively narrow full-width at half-maximum (FWHM) of 17 nm (0.064 eV) in dilute toluene. Moreover, the corresponding phosphorescent-sensitized fluorescence OLED achieves yellow emission maximum at 581 nm, with a narrow FWHM of 25 nm, a high maximum external quantum efficiency of 36.1 %, and a luminance exceeding 40,000 cd m −2 . These outstanding photoluminescent and electroluminescent performances validate the superiority of our molecular design strategy, highlighting its significant potential for cutting-edge optoelectronic applications.}, archive = {J_ANGEW}, author = {Jia-Jun Hu and Xiao Liang and Zhi-Ping Yan and Jia-Qi Liang and Hua-Xiu Ni and Li Yuan and Jing-Lin Zuo and You-Xuan Zheng}, doi = {10.1002/anie.202421102}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421102}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An efficient ultra-narrowband yellow emitter based on a double-boron-embedded tetraazacyclophane}, volume = {64}, year = {2025}, }
• (2025). A robust dual-layered solid electrolyte interphase enabled by cation specific adsorption-induced built-in electrostatic field for long-cycling solid-state lithium metal batteries. ANGEW, 64(10), e202421101. (www)

  @article{ , abstract = {Solid-state lithium (Li) metal batteries (SSLMBs) are considered as one of the most promising next-generation battery technologies due to their high energy density and intrinsic safety. However, interfacial issues such as side reactions and Li dendrite growth severely hinder the practical application of SSLMBs. In this contribution, we proposed a cationic built-in electrostatic field to drive the generation of an anion-derived dual-layered solid electrolyte interphase (SEI). The specific adsorption of tributylmethyl-phosphonium bis(trifluoromethanesulfonyl)imide (TMPB) cations onto negatively charged Li anode surface significantly prevents interfacial side reactions between vulnerable polyethylene oxide (PEO) and Li metal. More importantly, the formed cationic built-in electrostatic field induces the targeted trapping of Li-salt anions onto the Li metal surface, leading to the generation of an anion-derived dual-layered SEI, composed of a mechanically flexible organic-rich surface layer and a Li-ion conductive inorganic-rich bottom layer. As a result, the Li||Li cell demonstrated an extended lifespan of over 1900 hours with the reduced polarization voltage. The Li||LiFePO 4 full cell also exhibited excellent cycling stability, maintaining an average Coulombic efficiency of 99.7 % over 200 cycles at 0.5 C. This work provides valuable insights into mitigating interfacial degradation and promoting uniform Li deposition through surface electrostatic field regulation.}, archive = {J_ANGEW}, author = {Xi-Long Wang and Yuan Li and Jia Liu and Shi-Jie Yang and Jiang-Kui Hu and Wei-Qi Mai and Rui Wen and Hong Yuan and Jia-Qi Huang}, doi = {10.1002/anie.202421101}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421101}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A robust dual-layered solid electrolyte interphase enabled by cation specific adsorption-induced built-in electrostatic field for long-cycling solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Radar-terahertz-infrared compatible stealth coaxial silver Nanowire@Carbon nano-cable aerogel. ANGEW, 64(10), e202421090. (www)

  @article{ , abstract = {Achieving multi-spectrum compatible stealth in radar-terahertz-infrared bands with robust performance has great prospects for both military and civilian applications. However, the progress of materials encounters substantial challenges due to the significant variability in frequency coupling properties across different electromagnetic wave bands. Here, this work presents the design of a multi-scale structure and fabricates a lightweight aerogel (silver nanowire@carbon, AgNW@C) consisting of a regular coaxial nano-cable, with silver nanowire as the core and amorphous-graphitized hybrid carbon as the outer-layer. The design utilizes the one-dimensional conductive network and electric coupling heterogeneous interface, the low infrared emission of silver nanowires, and the thermal insulation caused by three-dimensional pore structure found in aerogels. This conception achieves the long-standing goal of multi-spectrum compatible stealth in an integrated material. The AgNW@C aerogel exhibits an optimal reflection loss of −66.50 dB and an effective absorption bandwidth of 8.80 GHz in the gigahertz band, while an average total shielding performance of 71.92 dB and over 50.00 dB reflection loss in the terahertz band. Furthermore, the AgNW@C aerogel demonstrates remarkable thermal infrared stealth capabilities with a low infrared emissivity of 0.28 and thermal insulation up to 150 °C under 200 °C. These exceptional multispectral stealth properties allow the aerogel for potential applications in military camouflage technology and electromagnetic protection.}, archive = {J_ANGEW}, author = {Hualong Peng and Bo Cai and Yu Zhang and Longcheng Gao and Pei-Yan Zhao and Lu Zhou and Shan Zhang and Wenhao Liang and Qi-Fan Xuan and Martin C. Koo and Chen-Ming Liang and Wen-Ping Li and Zhi-Ling Hou and Tao Zhou and Guang-Sheng Wang}, doi = {10.1002/anie.202421090}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421090}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radar-terahertz-infrared compatible stealth coaxial silver Nanowire@Carbon nano-cable aerogel}, volume = {64}, year = {2025}, }
• (2025). A high-entropy engineering on sustainable anionic redox mn-based cathode with retardant stress for high-rate sodium-ion batteries. ANGEW, 64(10), e202421089. (www)

  @article{ , abstract = {Manganese-based (Mn-based) layered oxides have emerged as competitive cathode materials for sodium-ion batteries (SIBs), primarily due to their high energy density, cost-effectiveness, and potential for mass production. However, these materials often suffer from irreversible oxygen redox reactions, significant phase transitions, and microcrack formation, which lead to considerable internal stress and degradation of electrochemical performance. This study introduces a high-entropy engineering strategy for P2-type Mn-based layered oxide cathodes (HE-NMCO), wherein a multi-ingredient cocktail effect strengthens the lattice framework by modulating the local environmental chemistry. This innovative approach fosters sustainable reversible oxygen activity, mitigates stress concentrations at grain boundaries, and accelerates Na + transport kinetics. The resulting robust lattice framework with optimized elemental interactions significantly improves structural integrity and reduces the formation of intragranular fractures. Consequently, HE-NMCO demonstrates remarkable cycling stability, retaining 93.5 % capacity after 100 deep (de)sodiation cycles, alongside an enhanced rate capability of 134.1 mAh g −1 at 5 C. Notably, comparative studies through multimodal characterization techniques highlight HE-NMCO′s superior reversibility in oxygen anion redox (OAR) reactions over extensive cycling, contrasting sharply with conventional NMCO cathode. This work elucidates the potential for advancing high energy and power density Mn-based cathodes for SIBs through local species diversity.}, archive = {J_ANGEW}, author = {Shiqi Liu and Fangzheng Liu and Shu Zhao and Zengqing Zhuo and Dongdong Xiao and Zhongyi Cui and Yulong Wang and Boya Wang and Tianhao Wu and Yuming Li and Lisi Liang and Houbing Huang and Wanli Yang and Haijun Yu}, doi = {10.1002/anie.202421089}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421089}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A high-entropy engineering on sustainable anionic redox mn-based cathode with retardant stress for high-rate sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Hydroalkylation of vinylarenes by transition-metal-free in situ generation of benzylic nucleophiles using tetramethyldisiloxane and potassium tert-butoxide. ANGEW, 64(10), e202421077. (www)

  @article{ , abstract = {Hydrosilanes and Lewis bases are known to promote various reductive defunctionalizations, rearrangements, and silylation reactions, facilitated by enigmatic silicon/Lewis base-derived reactive intermediates. Despite the wide variety of transformations enabled by this reagent combination, no examples of intermolecular C(sp 3 )−C(sp 3 ) forming reactions have been reported. In this work, we've identified 1,1,3,3-tetramethyldisiloxane (TMDSO) and KO t Bu as a unique reagent combination capable of generating benzylic nucleophiles in situ from styrene derivatives, which can subsequently react with alkyl halides to give a new C(sp 3 )−C(sp 3 ) linkage via formal hydroalkylation. Mechanistic experiments suggest that the reaction proceeds through a key hydrogen atom transfer (HAT) step from a hydrosilane reducing agent to styrene, affording a benzylic radical that undergoes reductive radical polar crossover (RRPC) and subsequent S N 2 alkylation.}, archive = {J_ANGEW}, author = {Piers St. Onge and Hana Nugraha and Stephen G. Newman}, doi = {10.1002/anie.202421077}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421077}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydroalkylation of vinylarenes by transition-metal-free in situ generation of benzylic nucleophiles using tetramethyldisiloxane and potassium tert-butoxide}, volume = {64}, year = {2025}, }
• (2025). In-situ cross-linked polymers for enhanced thermal cycling stability in flexible perovskite solar cells. ANGEW, 64(10), e202421063. (www)

  @article{ , abstract = {Flexible perovskite solar cells (FPSCs) are a promising emerging photovoltaic technology, with certified power conversion efficiencies reaching 24.9 %. However, the frequent occurrence of grain fractures and interface delamination raises concerns about their ability to endure the mechanical stresses caused by temperature fluctuations. In this study, we employ an in situ polymerization molecule with extended functional end groups to preserve mechanical integrity during thermal cycling. The AMPS-DEA molecule chemically anchors to grain boundaries and cross-links neighboring grains, protecting the structure from stress accumulation. Additionally, its hydroxyl groups form bidentate chelation with SnO 2 , enhancing interfacial adhesion and preventing delamination. More importantly, the relaxed residual stress provided by AMPS-DEA allows the perovskite layer to adapt to temperature changes, effectively matching adjacent layers and preventing mechanical failure. Our findings demonstrate that AMPS-DEA modification not only boosts PCE to 25.78 % in rigid PSCs and 24.54 % in flexible PSCs but also improves stability, maintaining over 95 % efficiency after 10,000 bending cycles and 200 thermal cycles.}, archive = {J_ANGEW}, author = {Zhihao Li and Chunmei Jia and Hongzhuo Wu and Ying Tang and Jinbo Zhao and Zhenhuang Su and Xingyu Gao and Shuai Qiu and Hongxing Yuan and Meng Li}, doi = {10.1002/anie.202421063}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421063}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-situ cross-linked polymers for enhanced thermal cycling stability in flexible perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Investigating interaction dynamics of an enantioselective peptide-catalyzed acylation reaction. ANGEW, 64(10), e202421062. (www)

  @article{ , abstract = {Modern nuclear magnetic resonance (NMR) methods like carbon relaxation dispersion in the rotating frame ( 13 C−R 1ρ ) and proton chemical exchange saturation transfer ( 1 H-CEST) are key methods to investigate molecular recognition in biomacromolecules and to detect molecular motions on the μs to s timescale, revealing transient conformational states. Changes in kinetics can be linked to binding, folding, or catalytic events. Here, we investigated whether these methods allow detection of changes in the dynamics of a small, highly selective peptide catalyst during recognition of its enantiomeric substrates. The flexible tetrapeptide Boc- l -(π-Me)−His− A Gly- l −Cha− l -Phe−OMe, used for the monoacetylation of cycloalkane-diols, is probed at natural abundance using 13 C-R 1ρ and 1 H-CEST. Indeed, we detected differences in dynamics of the peptide upon interaction with the diol. Importantly, these differ depending on the enantiomer of the substrate used. These enantiospecific influences of the substrates on the dynamics of the peptide are rationalized using computational techniques. We find that even though one enantiomer reacts faster, as confirmed by reaction monitoring, the other is more tightly bound in DCM (as confirmed by 1 H-saturation transfer difference (STD) measurements). These findings provide insights into the recognition of the substrates and explain the selectivity differences observed between the solvents toluene and DCM.}, archive = {J_ANGEW}, author = {Matthias Brauser and Katja Petzold and Christina M. Thiele}, doi = {10.1002/anie.202421062}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Investigating interaction dynamics of an enantioselective peptide-catalyzed acylation reaction}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of atropisomeric tri-axis naphthalenes via Diels–Alder reaction and dehydrative aromatization of isobenzofurans. ANGEW, 64(10), e202421060. (www)

  @article{ , abstract = {Atropisomers with multiple stereogenic axes have attracted much attention due to their increasing significance in the fields of natural products, chiral materials, and drug discoveries. However, the catalytic stereoselective construction of axially chiral ring scaffolds with more than two axes on a single benzene ring remains a challenging task. Herein, we present an efficient method for synthesizing triaxially chiral polysubstituted naphthalene scaffolds via sequential Ni(II)-catalyzed Diels–Alder reaction of isobenzofurans and TfOH-promoted dehydrative aromatization reaction. Using 1,3-biarylisobenzofurans and β-aryl-substituted α,β-unsaturated N -acyl pyrazoles as modular reaction partners, a series of naphthalenes with 1,3,4-triaxes were synthesized with excellent enantioselectivities and diastereoselectivities. Furthermore, by attaching two pyrene chromophores to this novel triaxially chiral ring scaffold, a circularly polarized luminescence (CPL)-active dye exhibiting a remarkable luminescence dissymmetry factor ( g lum =−0.019) and high fluorescence quantum efficiency (Ø FL =0.29) was obtained, highlighting the potential applications of atropisomers with multiple stereogenic axes in the design of chiroptical organic materials.}, archive = {J_ANGEW}, author = {Yuan-Bo Du and Qi-Tao Lu and Yun-Shu Cui and Kai-Wen Wu and Yu Wang and Yu-Zhen Zhang and Zheng Zhao and Jun-Li Hou and Quan Cai}, doi = {10.1002/anie.202421060}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421060}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of atropisomeric tri-axis naphthalenes via Diels–Alder reaction and dehydrative aromatization of isobenzofurans}, volume = {64}, year = {2025}, }
• (2025). Programmed charge transfer in conjugated polymers with pendant benzothiadiazole acceptor for simultaneous photocatalytic H2O2 production and organic synthesis. ANGEW, 64(10), e202421040. (www)

  @article{ , abstract = {While being important candidate for heterogeneous photocatalyst, conjugated polymer typically exhibits random charge transfers between the alternating donor and acceptor units, which severely limits its catalytic efficiency. Herein, inspired by natural photosystem, the concept of guiding the charge migration to specific reaction sites is employed to significantly boost photocatalytic performance of linear conjugated polymers (LCPs) with pendant functional groups via creating programmed charge-transfer channels from the backbone to its pendant moiety. The pendant benzothiadiazole, as revealed in both in situ X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) calculations, can act as electron “reservoir” that aggregates electrons at the active sites. Moreover, the presence of charge-transfer channels, evidenced by transient absorption spectroscopy (TAS), accelerates the electron transfer, preventing the recombination of electrons and holes. As a result, in this elaborately-designed architecture, the photogenerated electron can move smoothly towards the reduction sites, facilitating the reduction of O 2 into H 2 O 2 , while remaining holes are directed to oxidation centers, simultaneously oxidizing furfuryl alcohol to furoic acid. The optimized photocatalyst LCP-BT demonstrates a competitive catalytic performance with H 2 O 2 productivity of 868.3 μmol L −1 h −1 (9.8 times higher than conventional random charge-transfer polymer LCP-1) and furfuryl alcohol conversion over 95 % after 6 h.}, archive = {J_ANGEW}, author = {Sizhe Li and Rong Ma and Chuanjun Tu and Weijie Zhang and Run Li and Yan Zhao and Kai A. I. Zhang}, doi = {10.1002/anie.202421040}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421040}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programmed charge transfer in conjugated polymers with pendant benzothiadiazole acceptor for simultaneous photocatalytic H2O2 production and organic synthesis}, volume = {64}, year = {2025}, }
• (2025). Thermal modulation of exciton recombination for high-temperature ultra-long afterglow. ANGEW, 64(10), e202421036. (www)

  @article{ , abstract = {Developing smart materials with tunable high-temperature afterglow (HTA) luminescence remains a formidable challenge. This study presents a metal-free doping system using boric acid as matrix and polycyclic aromatic hydrocarbons as dopants. This composition achieves dynamically tunable afterglow combining a bright blue HTA lasting for over ten seconds even at 150 °C and an ultra-long yellow room-temperature phosphorescence below 110 °C. The observed HTA is attributed to the thermally released exciton recombination within the dopant molecules, which shows excellent temperature tolerance compared to traditional triplet related phosphorescence and thermally activated delayed fluorescence. The planarity of dopants is extensively investigated playing a pivotal role in modulating Dexter electron transfer (ET) for capturing released electrons and thereby affecting the overall performance of tunable HTA. This work provides an efficient and universal doping strategy to engineer tunable HTA through the synergistic action of thermally releasing electrons, Dexter ET and exciton recombination.}, archive = {J_ANGEW}, author = {Ping Jiang and Bingbing Ding and Jiayi Yao and Lei Zhou and Zhenyi He and Zizhao Huang and Chenjia Yin and He Tian and Xiang Ma}, doi = {10.1002/anie.202421036}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421036}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermal modulation of exciton recombination for high-temperature ultra-long afterglow}, volume = {64}, year = {2025}, }
• (2025). Polymer-MOF network enabling ultrathin coating for post-combustion carbon capture. ANGEW, 64(10), e202421028. (www)

  @article{ , abstract = {Permeance-selectivity trade-off and high temperature resilience are key challenges in development of membranes for post-combustion carbon capture. While mixed matrix membranes (MMMs) consisting of polymers and metal–organic frameworks (MOFs) offer the potential to address the challenges, they are limited by the low loading of MOFs in the thin film layer. Herein, we propose an inverse synthesis strategy to form polymer-MOF networks by copolymerizing monomers with functionalized UiO-66 nanoparticles. This process yields a finely dispersed, easily processable solution, enabling defect-free, thin polymer-MOF coatings with up to 40 wt % MOF loading within the polyethylene oxide-based polymers on polyacrylonitrile supports. The membrane with 40 wt % MOF demonstrated a 212 % increment in CO 2 permeance at 25 °C and maintained a selectivity of 20 at 60 °C, which is attributed to the stable diffusivity selectivity of MOFs at high temperature. Furthermore, the membrane was evaluated with mixed gas and 83 % relative humidity (RH) at 60 °C, achieving a CO 2 permeance up to 2793 GPU and a CO 2 /N 2 selectivity of 21.6. This work offers insights into the design of practical mixed matrix membranes, which not only paves the way towards energy efficient carbon capture from flue gas, but also provides more possibilities for other applications.}, archive = {J_ANGEW}, author = {Shuting Fan and Canzeng Liang and Fan Feng and Karchun Wong and Kaiyu Wang and Shuyue Jia and Nitesh Bhuwania and Sheng Zhang and Sui Zhang}, doi = {10.1002/anie.202421028}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421028}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polymer-MOF network enabling ultrathin coating for post-combustion carbon capture}, volume = {64}, year = {2025}, }
• (2025). Electron delocalized ni active sites in spinel catalysts enable efficient urea oxidation. ANGEW, 64(10), e202421027. (www)

  @article{ , abstract = {The urea oxidation reaction (UOR) has attracted much attention as an efficient alternative reaction to oxygen evolution reaction (OER) due to its low required overpotential. Despite significant progress in efficient nickel-based catalysts, the fundamental issues regarding product selectivity control and dissociation mechanism during the UOR process have not been clarified. Here, we report that tuning the electron delocalization strength of Ni sites significantly affects the OH − binding sites, altering urea molecule dissociation patterns in alkaline systems. Using spinel NiCo 2 O 4 as a model catalyst, the charge delocalization strength of nickel active centers is influenced by the degree of phosphorus-substituted anions. Specifically, complete phosphorus-substituted spinel enhances N 2 selectivity up to 26.8 % with a peak current density of 300 mA ⋅ cm −2 , while partial phosphorus-substituted spinel achieves a Faraday efficiency of 78.1 % for liquid products (NO x − ). Experiments and theory reveal that strong charge delocalization at Ni sites favors remote-site attack on urea molecules by hydroxide ions, whereas weak delocalization prefers nearby-site attack, enhancing UOR efficiency and suppressing OER in both pathways.}, archive = {J_ANGEW}, author = {Hui-Jian Zhang and Zi-Qiang Chen and Xiao-Tong Ye and Kang Xiao and Zhao-Qing Liu}, doi = {10.1002/anie.202421027}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421027}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron delocalized ni active sites in spinel catalysts enable efficient urea oxidation}, volume = {64}, year = {2025}, }
• (2025). Site-selective C(sp3)−H and switchable C(sp3)−H/C(sp2)−H functionalization enabled by electron-deficient Cp*CF3Ir(III) catalyst and photosensitizer. ANGEW, 64(10), e202421026. (www)

  @article{ , abstract = {A site-selective functionalization of a C( sp 3 )−H bond was achieved in the presence of an intrinsically more reactive C( sp 2 )−H bond by controlling the orientation of a directing group via a photo-induced E / Z isomerization of an oxime ether. By combining E / Z isomerization and an electron deficient Cp* CF3 Ir(III) catalyst, the scope of oxime ethers in C( sp 3 )−H functionalization was successfully expanded. Based on this strategy, the order of C−H activation was switchable and successive C( sp 3 )−H/C( sp 2 )−H and C( sp 2 )−H/C( sp 3 )−H double functionalizations were accomplished to construct densely functionalized structures.}, archive = {J_ANGEW}, author = {Yuki Hirata and Shunsuke Kimura and Kosuke Higashida and Tatsuhiko Yoshino and Shigeki Matsunaga}, doi = {10.1002/anie.202421026}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421026}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-selective C(sp3)−H and switchable C(sp3)−H/C(sp2)−H functionalization enabled by electron-deficient Cp*CF3Ir(III) catalyst and photosensitizer}, volume = {64}, year = {2025}, }
• (2025). Controlled introduction of sp3 quantum defects in fluorescent carbon nanotubes by mechanochemistry. ANGEW, 64(10), e202421021. (www)

  @article{ , abstract = {Precise control over low-dimensional materials holds an immense potential for their applications in sensing, imaging and information processing. The controlled introduction of sp 3 quantum defects (color centers) can be used to tailor the optoelectronic properties of single-walled carbon nanotubes (SWCNTs) in the tissue transparency (>800 nm) and the telecommunication window. However, an uncontrolled functionalization of SWCNTs with defects leads to a loss of the NIR fluorescence. Here, we use mechanochemistry with aryldiazonium salts to create quantum defects in SWCNTs. The reaction proceeds within 5 min without solvents or illumination and can be controlled by a varied mechanochemical energy impact. By working in the solid-state, this method presents an alternative synthetic route and marks a crucial step for tailoring photophysics of SWCNTs.}, archive = {J_ANGEW}, author = {Miriam Sander and Justus T. Metternich and Pascal Dippner and Sebastian Kruss and Lars Borchardt}, doi = {10.1002/anie.202421021}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421021}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled introduction of sp3 quantum defects in fluorescent carbon nanotubes by mechanochemistry}, volume = {64}, year = {2025}, }
• (2025). A conductive cu-based Metal–Organic framework ribbon with high-density redox-active centers as cathode for stable high-capacity lithium-ion batteries. ANGEW, 64(10), e202421008. (www)

  @article{ , abstract = {Conductive Cu-based metal–organic framework (Cu-MOF) materials hold significant potential as cathodes for lithium-ion batteries (LIBs) due to their flexible structural design, high electronic conductivity, and independence from costly resources. However, their practical application is often limited by their capacity and cyclability. In this study, we report a one-dimensional Cu-MOF (DDA−Cu, DDA=1, 5-Diamino-4, 8-dihydroxy-9, 10-anthraceneedione) featuring extended π-d conjugated coordination ribbon and high-density redox-active centers, making it a stable, high-capacity cathode for LIBs. The π-d conjugated Cu−O 3 N motifs embedded within the ribbon not only serve as redox-active centers for enhanced lithium-ion storage capacity but also contribute to structural robustness, enabling resistance against electrode solubility in organic electrolytes, thus ensuring superior cyclability. Furthermore, these π-d conjugated Cu−O 3 N units promote efficient charge transfer, leading to high electronic conductivity at room temperature. These advantageous properties allow the Cu-MOF cathode to deliver a remarkable capacity (353 mAh g −1 at 0.05 A g −1 ) and exceptional cyclability, achieving capacity retention of 78 % after 1000 cycles, surpassing state-of-the-art MOF electrodes. Additionally, this DDA−Cu demonstrates considerable wettability with the electrolyte, achieving outstanding performance even when tested in a lean electrolyte environment (2 μL mg −1 ) with a high mass loading of the MOF (6.8 mg cm −2 ).}, archive = {J_ANGEW}, author = {Menghua Yang and Ying Wang and Yan-Fang Huang and Ji-Miao Xiao and Guo-Yu Zhu and Ying Fang and Xian-Chao Zhou and Jian-Hua Long and Mo Xie and De-Shan Bin and Dan Li}, doi = {10.1002/anie.202421008}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A conductive cu-based Metal–Organic framework ribbon with high-density redox-active centers as cathode for stable high-capacity lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Rendering proteins fluorescent inconspicuously: Genetically encoded 4-cyanotryptophan conserves their structure and enables the detection of ligand binding sites. ANGEW, 64(10), e202421000. (www)

  @article{ , abstract = {Cyanotryptophans (CN-Trp) are privileged multimodal reporters on protein structure. They are similar in size to the canonical amino acid tryptophan and some of them exhibit bright fluorescence which responds sensitively to changes in the environment. We selected aminoacyl-tRNA synthetases specific for 4-, 5-, 6-, and 7-CN-Trp for high-yield in vivo production of proteins with a single, site-specifically introduced nitrile label. The absorption maximum of 4-CN-Trp is distinct from Trp, allowing the selective excitation of its intense fluorescence. 4-CN-Trp fluoresces in the visible range with an intensity rivalling that of 7-hydroxy-coumarin. Crystal structures of maltose binding protein demonstrate near-complete structural conservation when a native buried Trp residue is replaced by 4-CN-Trp. Besides presenting an inconspicuous tag for live cell microscopy, the intense fluorescence of 4-CN-Trp enables measurements of subnanomolar ligand binding affinities in isotropic solution, as demonstrated by the complex between rapamycin and the peptidyl–prolyl isomerase FKBP12 furnished with a 4-CN-Trp residue in the substrate binding pocket. Furthermore, 4-CN-Trp residues positioned at different locations of a protein containing multiple tryptophan residues permits using fluorescence quenching experiments to detect the proximity of individual Trp residues to the binding site of aromatic ligands.}, archive = {J_ANGEW}, author = {Haocheng Qianzhu and Elwy H. Abdelkader and Adarshi P. Welegedara and Edan Habel and Nathan Paul and Rebecca L. Frkic and Colin J. Jackson and Thomas Huber and Gottfried Otting}, doi = {10.1002/anie.202421000}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202421000}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rendering proteins fluorescent inconspicuously: Genetically encoded 4-cyanotryptophan conserves their structure and enables the detection of ligand binding sites}, volume = {64}, year = {2025}, }
• (2025). How carbene ligands transform AuAg alloy nanoclusters for electrocatalytic urea synthesis. ANGEW, 64(10), e202420993. (www)

  @article{ , abstract = {Metal nanoclusters stabilized by N-heterocyclic carbene (NHC) ligands have attracted increasing interest for their special structures and diverse applications. However, developing synthetic strategies and extending the database of NHC-protected nanoclusters are still challenging tasks. In this work, a novel and rapid synthetic method is developed to prepare AuAg alloy nanocluster ligated by carbene based on the reactivity of nanoclusters. The rod-like carbene-capped bimetal nanocluster, [Au 13 Ag 12 (PPh 3 ) 8 (BMIm) 2 I 8 ]SbF 6 (Au 13 Ag 12 : BMIm), was achieved and characterized by a series of techniques. The alloy nanocluster consists of two vertex-sharing icosahedrons and carbene ligands, phosphine ligands, and I atoms. Interestingly, the introduced carbene ligands show strong coordination capabilities with Au, enhancing the interaction between metal core and ligands. To the best of our knowledge, the carbene-capped Au 13 Ag 12 : BMIm nanocluster is the first of its kind to show higher thermostability and higher sensitivity to light compared with the homogeneously capped analogue nanocluster ([Au 13 Ag 12 (PPh 3 ) 10 I 8 ]SbF 6 ). Density functional theory calculations attribute these properties to a unique delocalization of electrons within the frontier orbitals. Finally, the Au 13 Ag 12 : BMIm anchored on NiFe-LDH exhibits remarkable electrocatalytic activity in the electrosynthesis of urea from NO 3 − and CO 2 , achieving a urea production rate of 29.5 mmol g cat −1 h −1 with a Faradaic efficiency of 34 % at −0.5 V (vs. RHE).}, archive = {J_ANGEW}, author = {Jingjing Zhang and Yifei Zhang and Zhaoxian Qin and Zhiwen Li and Zhaohui Tong and Zhen Zhao and José A. Gascón and Gao Li}, doi = {10.1002/anie.202420993}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420993}, shortjournal = {Angew. Chem. Int. Edit.}, title = {How carbene ligands transform AuAg alloy nanoclusters for electrocatalytic urea synthesis}, volume = {64}, year = {2025}, }
• (2025). Efficient hole extraction and *OH alleviation by pd nanoparticles on GaN nanowires in seawater for solar-driven h2 and H2O2 generation. ANGEW, 64(10), e202420796. (www)

  @article{ , abstract = {Photocatalytic seawater splitting into hydrogen and hydrogen peroxide (2H 2 O→H 2 ↑ + H 2 O 2 ) offers an ultimate solution for simultaneously generating green fuel and value-added chemicals by the two most earth-abundant resources i.e., solar energy and natural seawater. In this study, Pd nanoparticles are integrated with one-dimensional gallium nitride nanowires (Pd NPs/GaN NWs) on a silicon wafer to produce H 2 and H 2 O 2 from seawater powered by sunlight. In situ spectroscopic characterizations combined with computational investigations reveal that in this nanohybrid, Pd NPs function as an efficient hole extractor and *OH alleviator during photocatalysis. Meanwhile, the chloride ions in seawater facilitate the H 2 O→ H 2 + H 2 O 2 conversion by improving the charge dynamics and lowering the energy barrier of the key *OH self-coupling step over Pd sites in the catalytic system. As a result, the photocatalyst delivers an appreciable hydrogen production rate of 2.5 mmol⋅cm −2 ⋅h −1 with a light-to-hydrogen (LTH) efficiency of 4.38 % in natural seawater under concentrated light irradiation of 3 W⋅cm −2 without sacrificial agents and external energies. Notably, the water oxidation reaction produces 300 μmol/L of valuable H 2 O 2 over a duration of 2 hours under a light intensity of 3 W/cm 2 using a 20 mL water sample, achieving a light-to-chemical efficiency of 0.53 %. The photocatalyst shows excellent stability for up to 60 hours with a considerable turnover number of 1.42×10 7 moles H 2 per mole of Pd. The outdoor test further suggests the great potential for solar-driven seawater splitting into green fuels and chemicals.}, archive = {J_ANGEW}, author = {Muhammad Salman Nasir and Ying Zhao and Haotian Ye and Tao Wang and Bowen Sheng and Jun Song and Jinglin Li and Ping Wang and Xinqiang Wang and Zhen Huang and Baowen Zhou}, doi = {10.1002/anie.202420796}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420796}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient hole extraction and *OH alleviation by pd nanoparticles on GaN nanowires in seawater for solar-driven h2 and H2O2 generation}, volume = {64}, year = {2025}, }
• (2025). Unconventional interconnected high-entropy alloy nanodendrites for remarkably efficient C−C bond cleavage toward complete ethanol oxidation. ANGEW, 64(10), e202420752. (www)

  @article{ , abstract = {Developing ethanol oxidation electrocatalysts with high catalytic activity, durability, and resistance to CO poisoning remains a major challenge. In recent years, high-entropy alloys (HEAs) with unique physical and chemical properties have garnered substantial attention. Herein, a class of HEA nanodendrites are designed by a simple wet-chemical method. The mass activity and specific activity of the septenary PtIrRhCoFeNiCu high-entropy alloy catalyst are 2.13 A mg Pt −1 /1.05 A mg Pt+Ir+Rh −1 and 2.95 mA cm −2 , which reach 5.76-/2.84-fold and 5.57-fold improvements relative to commercial Pt/C (0.37 A mg Pt −1 and 0.53 mA cm −2 ), respectively. Remarkably, after the i-t test of up to 100,000 s and the accelerated durability test of 1500 cycles, 81.22 % and 68.54 % of the initial mass activity are well retained, respectively. The lattice distortion-associated local tensile strain as demonstrated by increased Pt−Pt bond length enhances ethanol adsorption and reduces reaction barriers. Moreover, hysteresis diffusion effect induced by lattice distortion in the HEA nanodendrites contributes to their superb ethanol oxidation stability. In situ infrared absorption spectroscopy reveals that the three HEA nanodendrites mainly follow C1 pathway with C−C bond breaking to form CO followed by CO oxidation especially at a wide range of high potentials. Theoretical calculations reveal that among these HEAs, PtIrRhCoFeNiCu possesses the lowest energy barrier for C−C bond scission due to synergy among Pt/Ir/Rh and water dissociation due to synergy among Co/Fe/Ni/Cu. This work provides insights to design unique HEA nanostructures with extraordinary catalytic performances and selectivity compared to conventional nanoparticles.}, archive = {J_ANGEW}, author = {Yan Wang and Huiying Meng and Renqin Yu and Jie Hong and Yifan Zhang and Zhonghong Xia and Yong Wang}, doi = {10.1002/anie.202420752}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420752}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unconventional interconnected high-entropy alloy nanodendrites for remarkably efficient C−C bond cleavage toward complete ethanol oxidation}, volume = {64}, year = {2025}, }
• (2025). CO cryo-sorption as a surface-sensitive spectroscopic probe of the active site density of single-atom catalysts. ANGEW, 64(10), e202420673. (www)

  @article{ , abstract = {Quantifying the number of active sites is a crucial aspect in the performance evaluation of single metal-atom electrocatalysts. A possible realization is using adsorbing gas molecules that selectively bind to the single-atom transition metal and then probing their surface density using spectroscopic tools. Herein, using in situ X-ray photoelectron spectroscopy (XPS) and near edge X-ray absorption fine structure (NEXAFS) spectroscopy, we detect adsorbed CO gas molecules on a FeNC oxygen reduction single atom catalyst. Correlating XPS and NEXAFS, we develop a simple surface- and chemically-sensitive protocol to accurately and quickly quantify the active site density. Density functional theory-based X-ray spectra simulations reaffirm the assignment of the spectroscopic fingerprints of the CO molecules adsorbed at Fe-N 4 -C sites, and provide additional unexpected structural insights about the active site needed to explain the low-temperature CO adsorption. Our work represents an important step towards an accurate quantitative catalytic performance evaluation, and thus towards developing reliable material design principles and catalysts.}, archive = {J_ANGEW}, author = {Beomgyun Jeong and Hafiz Ghulam Abbas and Benedikt P. Klein and Geunsu Bae and Adith Ramakrishnan Velmurugan and Chang Hyuck Choi and Geonhwa Kim and Dongwoo Kim and Ki-jeong Kim and Byeong Jun Cha and Young Dok Kim and Frédéric Jaouen and Reinhard J. Maurer and Stefan Ringe}, doi = {10.1002/anie.202420673}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420673}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CO cryo-sorption as a surface-sensitive spectroscopic probe of the active site density of single-atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Enantioselective Borylcupration/Cyclization of alkene-tethered oxime esters. ANGEW, 64(10), e202420479. (www)

  @article{ , abstract = {A copper-catalyzed enantioselective synthesis of borylated 1-pyrrolines from γ , δ -unsaturated oxime esters is reported. Twenty-four novel 1-pyrroline derivatives are reported in yields ranging from 26% to 96% and enantioselectivities from 74.5:25.5 er to 99:1 er. Examples derived from α -unsubstituted, non-fluorinated oxime esters are reported. The hydroxyl group following oxidation of the Bpin moiety acts as a directing group in highly diastereoselective reductions of the pyrrolines to the corresponding prolinol derivatives. Additionally, the Bpin group can be retained in the products following a simplified, chromatography-free workup procedure. DFT supports a reaction mechanism which proceeds through the formation of an ( R )-benzylic copper intermediate, followed by stereoretentive cyclization with respect to the configuration at the metalated carbon. The conclusions of the computational data are corroborated through control experiments and deuterium-labelling studies.}, archive = {J_ANGEW}, author = {Jonathan Bajohr and Shangyu Li and Bijan Mirabi and Colton E. Johnson and Mark Lautens}, doi = {10.1002/anie.202420479}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420479}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective Borylcupration/Cyclization of alkene-tethered oxime esters}, volume = {64}, year = {2025}, }
• (2025). Industrial-level paired electrosynthesis of valuable chemicals over a high-performance heterostructural electrode. ANGEW, 64(10), e202420353. (www)

  @article{ , abstract = {Paired electrosynthetic technology is of significance to realize the co-production of high-added value chemicals. However, exploiting efficient bifunctional electrocatalyst of the concurrent electrocatalysis to achieve the industrial-level performance is still challenging. Herein, an amorphous Co 2 P@MoO x heterostructure is rationally designed by in situ electrodeposition strategy, which is acted as excellent bifunctional catalysts for the electrocatalytic nitrite reduction reaction (NO 2 RR) and glycerol oxidation reaction (GOR). The membrane-electrode assembly (MEA) electrolyzer realizes a low voltage of 1.30 V, robust stability over 200 h at 100 mA cm −2 , high Faraday efficiencies and yield of NH 3 (above 95 %, 49.7 mg h −1 cm −2 ) and formate (above 95 %, 304.4 mg h −1 cm −2 ) at industrial-level current density of 500 mA cm −2 . In situ spectroscopy studies have shown that high-valence CoOOH is the main active material of GOR, and the main catalytic conversion pathway of NO 2 RR involves key *NH 2 OH reaction intermediates. In addition, theoretical calculations confirm that the Co 2 P@MoO x heterostructure has strong interfacial electronic interaction and optimized reaction energy barriers, which endows its intrinsically high electrocatalytic activity for the co-electrosynthesis of NH 3 and formate.}, archive = {J_ANGEW}, author = {Guorong Zhou and Han Cheng and Yilin Wu and Yun Tong and Ruihao Dai and Jiaye Zhu and Xiaonan Zheng and Cong Lin and Pengzuo Chen and Changzheng Wu}, doi = {10.1002/anie.202420353}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Industrial-level paired electrosynthesis of valuable chemicals over a high-performance heterostructural electrode}, volume = {64}, year = {2025}, }
• (2025). Precise regulation of intra-nanopore charge microenvironment in covalent organic frameworks for efficient monovalent cation transport. ANGEW, 64(10), e202420333. (www)

  @article{ , abstract = {Charged channels are considered an effective design for achieving efficient monovalent cation transport; however, it remains challenging to establish a direct relationship between charge microenvironments and ionic conductivity within the pores. Herein, we report a series of crystalline covalent organic frameworks (COFs) with identical skeletons but different charge microenvironments and explore their intra-pore charge-driven ion transport performance and mechanism differences. We found that the charged nature determines ion-pair action sites, modes, host-guest interaction, thereby influencing the dissociation efficiency of ion pairs, the hopping ability of cations, and the effective carrier concentration. The order of transport efficiency for Li + , Na + , and H + follows anion > zwitterion > cation > neutrality. Ionic COFs exhibit up to 11-fold higher ionic conductivity than neutral COFs. Notably, the ionic conductivity of anionic COF achieves 2.0 × 10 −4 S cm −1 for Li + at 30 °C and 3.8 × 10 −2 S cm −1 for H + at 160 °C, surpassing most COF-based ionic conductors. This COF platform for efficient ion migration and stable battery cycling in lithium-metal quasi-solid-state batteries has also been verified as proof of concept. This work offers new insights into the development and structure-activity relationship studies of the next generation of solid-state ionic conductors.}, archive = {J_ANGEW}, author = {Guoxing Jiang and Wenwu Zou and Zhaoyuan Ou and Weifeng Zhang and Junlang Huo and Shengguang Qi and Liming Wang and Li Du}, doi = {10.1002/anie.202420333}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420333}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise regulation of intra-nanopore charge microenvironment in covalent organic frameworks for efficient monovalent cation transport}, volume = {64}, year = {2025}, }
• (2025). Non-substituted aromatic pyridine N-oxide additives with an intrinsic N→O acceptor for ultra-long-life Zn||MnO2 batteries. ANGEW, 64(10), e202420183. (www)

  @article{ , abstract = {Various organic and inorganic reagents containing N/O functional groups have been developed as additives to aqueous electrolytes (e.g., ZnSO 4 , ZS) of zinc-ion batteries (ZIBs). However, finding an additive that can significantly enhance the durability of Zn anodes by inhibiting Zn dendrites and side reactions remains a considerable challenge. Herein, pyridine N-oxide (PNO), a non-substituted aromatic compound with a nitrogen positive charge-induced N→O bond, is explored as ZS additives for highly durable Zn plating/stripping electrolytes (i.e., PNO/ZS). The optimized PNO 0.03 /ZS mixture demonstrates exceptional stability for Zn anodes, achieving a cycle life exceeding 4200 h and a Coulombic efficiency of 99.9 % at 1 mA cm −2 and 1 mAh cm −2 . It maintains over 1000 h of life and a cumulative capacity of 2.5 Ah cm −2 , even when subjected to plating/stripping conditions intensified by a factor of 5. Importantly, it enables Zn|| α -MnO 2 cells to sustain high-current charge/discharge cycles for over 5000 cycles, retaining 80 % (125 mAh g −1 ) of the initial capacity, which is the best performance reported for similar additive systems. This exceptional stability is ascribed to the highly reversible Zn anode plating/stripping, facilitated by the suitable coordination interactions between the N→O acceptor of PNO and the Zn 2+ /H 2 O donor, effectively inhibiting side reactions.}, archive = {J_ANGEW}, author = {Qin Kang and Hongyu Liang and Zhaomin Zhu and Fuxu Xing and Bingzheng Zhu and Yuman Li and Shihao Wang and Shengda Tang and Hui Li and Li Pan and Lijun Yang and Tangming Mo and Yongfeng Bu}, doi = {10.1002/anie.202420183}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-substituted aromatic pyridine N-oxide additives with an intrinsic N→O acceptor for ultra-long-life Zn||MnO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Organic-free synthesis of high-silica zeolite y with aluminophosphate as the aluminum carrier. ANGEW, 64(10), e202420080. (www)

  @article{ , abstract = {The wide application of zeolite Y in petrochemical industry is well-known as one of the milestones in zeolite chemistry and heterogeneous catalysis. However, the traditional organic-free synthesis typically produces (hydro)thermally unstable zeolite Y with Si/Al atomic ratio (SAR) less than 2.5. Inspired by drug delivery process in which active components are kinetically controlled released, we develop a unique approach based on the pre-synthesized aluminum carrier to prepare one of the most siliceous zeolite Y with SAR up to 3.44 without using organics. The crystalline or amorphous aluminophosphates serve as the ideal carrier for the controlled incorporation of Al into zeolite framework during zeolite Y crystallization. Experimental and theoretical results reveal that the partial introduction of aluminophosphate as Al source would rationally regulate the crystallization kinetics, facilitating the formation of high-silica zeolite Y with random Al distribution. This approach enhances the hydrothermal stability and catalytic performance of zeolite Y in benchmark reaction.}, archive = {J_ANGEW}, author = {Qingdi Zhao and Jiejie Ling and Jilong Wang and Yan Gao and Hailang Liu and Zhenghan Zhang and Jingang Jiang and Akira Nakayama and Jian Li and Koki Muraoka and Peng Wu and Le Xu}, doi = {10.1002/anie.202420080}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202420080}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic-free synthesis of high-silica zeolite y with aluminophosphate as the aluminum carrier}, volume = {64}, year = {2025}, }
• (2025). Room temperature ethene to propene (ETP) tandem catalysis using single crystalline solid-state molecular pre-catalysts. ANGEW, 64(10), e202419923. (www)

  @article{ , abstract = {A tandem catalytic ensemble of solid-state molecular organometallic (SMOM) crystalline pre-catalysts are deployed under batch or flow conditions for the ethene to propene process (ETP). These catalysts operate at ambient temperature and low pressure, via sequential ethene dimerization, butenes isomerization and cross-metathesis. Under flow conditions the on-stream ethene conversion (55 %), initial propene selectivity (92 %), stability (71 % selectivity after 7 h) and low temperature/pressures are competitive with the best-in-class heterogeneous systems, marking a new, in crystallo , approach to ETP.}, archive = {J_ANGEW}, author = {Kristof M. Altus and Yiping Shi and Patrick Probst and Jack H. Heaton and Matthew R. Gyton and Leonardo Lari and Michael R. Buchmeiser and Philip W. Dyer and Andrew S. Weller}, doi = {10.1002/anie.202419923}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202419923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Room temperature ethene to propene (ETP) tandem catalysis using single crystalline solid-state molecular pre-catalysts}, volume = {64}, year = {2025}, }
• (2025). Cationic polyhedral chalcogenaboranes: Activation without breaking wade's rules. ANGEW, 64(10), e202419677. (www)

  @article{ , abstract = {Wade's rules are a well-established tool for the description of the geometry of inorganic clusters. Among others, they state that a decrease or increase in charge is always accompanied by a change in the number of skeletal electron pairs (SEPs). This work reports the synthesis of the first cationic chalcogenaboranes closo -[12-X-2-IPr-1-EB 11 H 10 ]BF 4 (IPr=1,3-(2,6- i Pr 2 C 6 H 3 )-imidazole-2-ylidene; X=H, I; E=S, Se 3 a/b , 4 a/b ) featuring the same SEP count as their neutral precursors, EB 11 H 11 , but bearing a positive charge. This ionisation significantly enhances the activity towards the electrophiles. It unlocks reactivity with very weak bases and offers the control of the regioselectivity towards hard/soft bases by the modulation of LUMO. The localisation of the positive charge within the borane cluster has been confirmed experimentally, spectroscopically and theoretically.}, archive = {J_ANGEW}, author = {Josef Holub and Šimon-Petr Náhlík and Zdeňka Růžičková and Maksim A. Samsonov and Drahomír Hnyk and Josef Cvačka and Jindřich Fanfrlík and Jan Vrána and Aleš Růžička}, doi = {10.1002/anie.202419677}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202419677}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cationic polyhedral chalcogenaboranes: Activation without breaking wade's rules}, volume = {64}, year = {2025}, }
• (2025). Operando nanoscale characterization reveals fe doping of ni oxide enhances oxygen evolution reaction via fragmentation and formation of dual active sites. ANGEW, 64(10), e202419521. (www)

  @article{ , abstract = {Efficient catalytic water splitting demands advanced catalysts to improve the slow kinetics of the oxygen evolution reaction (OER). Earth-abundant transition metal oxides show promising OER activity in alkaline media. However, most experimental information available is either from post-mortem studies or in situ space-averaged X-ray techniques in the micrometer range. Therefore, the composition of the active centers under operando conditions is still under debate. In this work, we combine nanoscopic and spectroscopic measurements on the hydroxylation of molecular beam epitaxy (MBE)-prepared Ni and NiFe oxides nanoislands with operando local investigations of Ni and NiFe hydroxide electrocatalysts under OER conditions to reveal the nature of the active centers in 2D OER catalysts. Our results reveal that Fe doping increases the active surface area by island fragmentation, and boosts the intrinsic activity by creating optimized active centers consisting of both Ni and Fe atoms. In addition, our findings show that operando characterization at the nanoscale is crucial to reveal the dynamic nature of the interface of 2D catalysts under reaction conditions.}, archive = {J_ANGEW}, author = {Yunchang Liang and Sofia O. Parreiras and Seunghwa Lee and Karla Banjac and Victor Boureau and José M. Gallego and Xile Hu and David Écija and Magalí Lingenfelder}, doi = {10.1002/anie.202419521}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202419521}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Operando nanoscale characterization reveals fe doping of ni oxide enhances oxygen evolution reaction via fragmentation and formation of dual active sites}, volume = {64}, year = {2025}, }
• (2025). Non-monotonic variation of potential-dependent surface diffusion at electrochemical interfaces in the presence of coadsorbates. ANGEW, 64(10), e202419390. (www)

  @article{ , abstract = {The influence of coadsorbed ions on adsorbate diffusion, an inherent effect at solid–liquid interfaces, was studied for adsorbed sulfur on Ag(100) electrodes in the presence of bromide or iodide. Quantitative in situ high-speed scanning tunnelling microscopy (video-STM) measurements were performed both in the potential regime of the c(2×2) halide adlayer at its saturation coverage and in the regime of a disordered adlayer where the halide coverage increases with potential. These studies reveal a surprising non-monotonic potential dependence of S a d diffusion with an initial increase with halide coverage, followed by a decrease upon halide adlayer ordering into the c(2×2) structure. Density functional theory (DFT) and Monte Carlo (MC) simulations only qualitatively reproduce the rise in S a d mobility with halide coverage, suggesting that many-adsorbate interactions and the presence of the electrolyte need to be considered.}, archive = {J_ANGEW}, author = {Chaolong Yang and Reihaneh Amirbeigiarab and Sönke Buttenschön and Eckhard Pehlke and Olaf M. Magnussen}, doi = {10.1002/anie.202419390}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202419390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-monotonic variation of potential-dependent surface diffusion at electrochemical interfaces in the presence of coadsorbates}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of discobahamin a and putative structure of discobahamin b via an isocyanide-based macrocyclization reaction. ANGEW, 64(10), e202419383. (www)

  @article{ , abstract = {We report in this paper the first total synthesis of discobahamin A, a 24-membered macrocyclopeptide containing an α -keto amide functional group. We assign the absolute configuration of 2-hydroxy-3-methylpentanoic acid (Hmp), the side chain capping the N-terminus of the macrocycle, as the (2 S , 3 S ) stereoisomer. A novel macrocyclization strategy was developed, utilizing an intramolecular Passerini reaction between ω -isocyano aldehyde and acetic acid. Notably, this macrocyclization proceeds via C(sp 3 )-C(sp 2 ) bond formation and de novo generation of an α -keto amide functional group. Furthermore, we synthesized both the proposed structure of discobahamin B and its diastereomer. However, the spectroscopic data for these two compounds do not fully align with those reported for discobahamin B.}, archive = {J_ANGEW}, author = {Baochao Yang and Qian Wang and Jieping Zhu}, doi = {10.1002/anie.202419383}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202419383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of discobahamin a and putative structure of discobahamin b via an isocyanide-based macrocyclization reaction}, volume = {64}, year = {2025}, }
• (2025). Dry-solid-electrochemical synthesis: A general method for large scale synthesis of single-atom catalysts with high metal loadings. ANGEW, 64(10), e202419374. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) with high metal loadings are highly desirable but still challenging for large scale synthesis. Here we report a new technique named as dry-solid-electrochemical synthesis (DSES) for a general large-scale synthesis of SACs with high metal loadings in an energy-conservation and environment-friendly way. With it, a series of pure carbon-supported metal SACs (Platinum up to 35.0 wt %, Iridium 21.2 wt %, Ruthenium 20.4 wt % and Iron 17.6 wt %) with high metal loadings were obtained. Particularly, a Pt SAC with Pt 23.9 wt % and remarkable oxygen reduction reaction (ORR) performance in fuel cells is synthesized on kilogram scale. Based on multiple control experiments, a unique redox mechanism for DSES process is proposed: metal precursors on conductive supports are reduced to metals via a homolytic cleavage of metal-halogen bonds by the attacking of electrons flowing through the dry solid phase. Such versatile technique paves a new economical and environment-friendly pathway for fabricating high-metal-loading SACs or atomic dispersion catalysts.}, archive = {J_ANGEW}, author = {Xue Gong and Jinpeng Bao and Xian Wang and Xin Wan and Yaheng Gu and Ce Han and Jianglan Shui and Xiaozhi Su and Junjie Ge and Wei Xing and Ping Song and Weilin Xu}, doi = {10.1002/anie.202419374}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202419374}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dry-solid-electrochemical synthesis: A general method for large scale synthesis of single-atom catalysts with high metal loadings}, volume = {64}, year = {2025}, }
• (2025). Bias-induced Ga−O-ir interface breaks the limits of adsorption-energy scaling relationships for high-performing proton exchange membrane electrolyzers. ANGEW, 64(10), e202419352. (www)

  @article{ , abstract = {Rationally manipulating the in situ formed catalytically active surface of catalysts remains a significant challenge for achieving highly efficient water electrolysis. Herein, we present a bias-induced activation strategy to modulate in situ Ga leaching and trigger the dynamic surface restructuring of lamellar Ir@Ga 2 O 3 for the electrochemical oxygen evolution reaction. The in situ reconstructed Ga−O−Ir interface sustains high water oxidation rates at oxygen evolution reaction (OER) overpotentials. We found that OER at the Ga−O−Ir interface follows a bi-nuclear adsorbate evolution mechanism with unsaturated IrO x as the active sites, while GaO x atoms play an indirect role in promoting water dissociation to form OH* and transferring OH* to Ir sites. This breaks the scaling relationship of the adsorption energies between OH* and OOH*, significantly lowering the energy barrier of the rate-limiting step and greatly increasing reactivity. The Ir@Ga 2 O 3 catalyst achieves lower overpotentials, a current density of 2 A cm −2 at 1.76 V, and stable operation up to 1 A cm −2 in scalable proton exchange membrane water electrolyzer (PEMWE) at 1.63 V, maintaining stable operation at 1 A cm −2 over 1000 hours with a degradation rate of 11.5 μV h −1 . This work prompted us to jointly address substrate–catalyst interactions and catalyst reconstruction, an underexplored path, to improve activity and stability in Ir PEMWE anodes.}, archive = {J_ANGEW}, author = {Yinnan Qian and Yirun Guo and Zijie Yang and Zhaoyan Luo and Lei Zhang and Qianling Zhang and Chuanxin He and Hao Zhang and Xueliang Sun and Xiangzhong Ren}, doi = {10.1002/anie.202419352}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202419352}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bias-induced Ga−O-ir interface breaks the limits of adsorption-energy scaling relationships for high-performing proton exchange membrane electrolyzers}, volume = {64}, year = {2025}, }
• (2025). Diplatinum single-molecular photocatalyst capable of driving hydrogen production from water via singlet-to-triplet transitions. ANGEW, 64(10), e202418884. (www)

  @article{ , abstract = {Solar-driven hydrogen production is regarded as one of the most ideal methods to achieve a sustainable society. In order to artificially establish efficient photosynthetic systems, efforts have been made to develop single-molecular photocatalysts capable of serving both as a photosensitizer (PS) and a catalyst (Cat) in hydrogen evolution reaction (HER). Although examples of such hybrid molecular photocatalysts have been demonstrated in the literature, their solar energy conversion efficiencies still remain quite limited. Here we demonstrate that a new dinuclear platinum(II) complex Pt 2 (bpia)Cl 3 (bpia=bis(2-pyridylimidoyl)amido) serves as a single-molecular photocatalyst for HER with its performance significantly higher than that of the PtCl(tpy)- and PtCl 2 (bpy)-type photocatalysts developed in our group (tpy=2,2':6′,2''-terpyridine, bpy=2,2′-bipyridine). The outstanding feature is that Pt 2 (bpia)Cl 3 can produce H 2 even by irradiating the lower-energy light above 500 nm, which is rationalized due to the direct population of triplet states via singlet-to-triplet transitions (i.e., S-T transitions) accelerated by the diplatinum core. To the best of our knowledge, Pt 2 (bpia)Cl 3 is the first example of a single-molecular photocatalyst enabling hydrogen production from water via the S-T transitions using lower-energy light (>580 nm).}, archive = {J_ANGEW}, author = {Toma Kunikubo and Raúl Castañeda and Muralee Murugesu and Jaclyn L. Brusso and Kosei Yamauchi and Hironobu Ozawa and Ken Sakai}, doi = {10.1002/anie.202418884}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202418884}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diplatinum single-molecular photocatalyst capable of driving hydrogen production from water via singlet-to-triplet transitions}, volume = {64}, year = {2025}, }
• (2025). Bridging electrolyte bulk and interfacial chemistry: Dynamic protective strategy enable ultra-long lifespan aqueous zinc batteries. ANGEW, 64(10), e202418524. (www)

  @article{ , abstract = {The main bottleneck of rechargeable aqueous zinc batteries (AZBs) is their limited cycle lifespans stemming from the unhealthy electrolyte bulk and fragile interface, especially in the absence of dynamic protection mechanism between them. To overcome this limitation, benefitting from their synergistic physical and chemical properties, chitin nanocrystals (ChNCs) are employed as superior colloid electrolyte to bridge electrolyte bulk and interfacial chemistry for ultra-long lifespan AZBs. This unique strategy not only enables continuous optimization of the electrolyte bulk and interfacial chemistry within the battery but also facilitates self-repairing of mechanical damage both internally and externally, thereby achieving comprehensive, persistent, and dynamic protection. As a result, the modified zinc (Zn) cells present high Zn plating/stripping coulombic efficiencies of 97.71 % ~99.81 % from 5 to 100 mA cm −2 , and remarkably service lifespan up to 8,200 h (more than 11 months). Additionally, the Zn//MnO 2 full cell exhibits a high capacity retention of 70.1 % after 3,000 cycles at 5 A g −1 . This dynamic protective strategy to challenge aqueous Zn chemistry may open up a new avenue for building better AZBs and beyond.}, archive = {J_ANGEW}, author = {Qing Wu and Jinlong Zhang and Song Yang and Fusheng Luo and Zeyu Yan and Xiude Liu and Haibo Xie and Jun Huang and Yiwang Chen}, doi = {10.1002/anie.202418524}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202418524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bridging electrolyte bulk and interfacial chemistry: Dynamic protective strategy enable ultra-long lifespan aqueous zinc batteries}, volume = {64}, year = {2025}, }
• (2025). Conformational plasticity and binding affinity enhancement controlled by linker derivatization in macrocycles. ANGEW, 64(10), e202418512. (www)

  @article{ , abstract = {Macrocycles are abundantly used by nature to enable cell-permeable bioactive molecules. Synthetic non-peptidic macrocycles are also increasingly considered as modalities for difficult-to-bind proteins but guidelines for macrocyclization are only beginning to emerge. Macrocycles are thought to constrain the available conformations but also to allow for residual flexibility, the latter being poorly understood. Here we show that even medium-sized macrocycles display an unexpected high conformational plasticity, even when bound to their protein target. Minor modification of the linker region of macrocycles can shift the conformational ensemble to distinct conformational subclasses, each constituting distinct three-dimensional scaffolds for further optimization. This led to several new ligands with improved affinity and beneficial physicochemical parameters for the FK506-binding protein 51, a promising target for depression, obesity and chronic pain. Importantly, none of the beneficial modifications could have been identified by classical medicinal chemistry as they only work in the macrocyclic context. Our results show that macrocyclization can do more than keeping loose ends together but rather provide a platform for multiple series of macrocycles with distinct binding modes.}, archive = {J_ANGEW}, author = {Vanessa Buffa and Carlo Walz and Christian Meyners and Min Zheng and Wisely Oki Sugiarto and Maximilian Repity and Hanaa Achaq and Christian Brudy and Moritz Spiske and Matijas Cica and Felix Hausch}, doi = {10.1002/anie.202418512}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202418512}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformational plasticity and binding affinity enhancement controlled by linker derivatization in macrocycles}, volume = {64}, year = {2025}, }
• (2025). Conformationally restricted macrocycles as improved FKBP51 inhibitors enabled by systematic linker derivatization. ANGEW, 64(10), e202418511. (www)

  @article{ , abstract = {Macrocycles are increasingly considered as promising modalities to target challenging intracellular proteins. However, strategies for transitioning from active linear starting points to improved macrocycles are still underdeveloped. Here we explored the derivatization of linkers as an approach for macrocycle optimization. Using the FK506-binding protein 51 (FKBP51) as a model system we prepared >140 macrocycles with systematically derivatized linkers. Two backbones were identified as promising frameworks for subsequent optimization. Surprisingly, co-crystal structure analyses revealed that these chemical templates represent an ensemble of three-dimensional (3D) conformations that can give rise to several distinct 3D-scaffolds. This resulted in a set of macrocycles with consistently improved affinity, plasma stability, and aqueous solubility compared to the linear precursors or the non-functionalized macrocycles. Our results highlight linkers as an opportunity for macrocyclic drug development, show how linker derivatization can improve the performance of macrocycles, and emphasizes the need to track macrocyclic scaffold evolution at a three-dimensional level.}, archive = {J_ANGEW}, author = {Moritz Spiske and Christian Meyners and Michael Bauder and Maximilian Repity and Christian Brudy and Wisely Oki Sugiarto and Hanaa Achaq and Thomas M. Geiger and Felix Hausch}, doi = {10.1002/anie.202418511}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202418511}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformationally restricted macrocycles as improved FKBP51 inhibitors enabled by systematic linker derivatization}, volume = {64}, year = {2025}, }
• (2025). Imine-based polymeric mixed Ionic–Electronic conductors featuring degradability and biocompatibility for transient bioinspired electronics. ANGEW, 64(10), e202417921. (www)

  @article{ , abstract = {Degradable features are highly desirable to advance next-generation organic mixed ionic–electronic conductors (OMIECs) for transient bioinspired artificial intelligence devices. It is highly challenging that OMIECs exhibit excellent mixed ionic-electronic behavior and show degradability simultaneously. Specially, in OMIECs, doping is often a tradeoff between structural disorder and charge carrier mobilities. Here, we describe a regiochemistry-driven backbone curvature approach to prepare OMIECs, enabling doped state ordered within efficient ionic-electronic conduction in organic electrochemical transistors (OECTs) and presenting degradable characteristics. Significantly, i -3gTIT shows an outstanding mobility (1.99 cm 2 V −1 s −1 ) and μ C* (302 F V −1 cm −1 s −1 ), and presents higher disorder-tolerance upon doping and faster degradation behavior than its regioisomer, o -3gTIT . Especially, the resulting OECT-based inverter shows a high voltage gain of 31.6 V V −1 at a low driving voltage of 0.6 V. Moreover, we demonstrate an application of transient OECT, i. e., biodegradable solid-state electrolyte of OECT-based artificial synapses. Remarkably, the regiochemistry-driven film crystallinity modulation enables the conversion from volatile to non-volatile operation in such synapses. The transient synapse based on i -3gTIT achieves over 90 % recognition accuracy for small digit handwritten images, showing potential in security neuromorphic computing. Our work is the first presentation enabling excellent mixed conduction of OMIECs with degradable features for transient bioinspired electronics.}, archive = {J_ANGEW}, author = {Junxin Chen and Shengyu Cong and Riping Liu and Jiayao Duan and Chaoyue Chen and Dongsheng Yu and Xiuyuan Zhu and Chong Ran and Du Cheng and Zhengke Li and Iain McCulloch and Wan Yue}, doi = {10.1002/anie.202417921}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202417921}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imine-based polymeric mixed Ionic–Electronic conductors featuring degradability and biocompatibility for transient bioinspired electronics}, volume = {64}, year = {2025}, }
• (2025). One-step esterification of phosphoric, phosphonic and phosphinic acids with organosilicates: Phosphorus chemical recycling of sewage waste. ANGEW, 64(10), e202416487. (www)

  @article{ , abstract = {Global concerns regarding the depletion and strategic importance of phosphorus resources have increased demand for the recovery and recycling. However, waste-derived phosphorus compounds, primarily as chemically inert phosphoric acid or its salts, present a challenge to their direct conversion into high-value chemicals. We aimed to develop an innovative technology that utilizes the large quantities of sewage waste, bypasses the use of white phosphorus, and enables esterification of phosphoric acid to produce widely applicable phosphate triesters. Tetraalkyl orthosilicates emerged as highly effective reagents for the direct triple esterification of 85 % phosphoric acid, as well as the esterification of organophosphinic and phosphonic acids. Furthermore, we achieved esterification of recovered phosphoric acid with tetraalkyl orthosilicate, thus pioneering a recycling pathway from sewage waste to valuable phosphorus chemicals. Experimental and theoretical investigations revealed a novel mechanism, wherein tetraalkyl orthosilicates facilitate multimolecular aggregation to achieve alkyl transfer from tetraalkylorthosilicate to phosphoric acid via multiple proton shuttling.}, archive = {J_ANGEW}, author = {Yuki Naganawa and Kei Sakamoto and Akira Fujita and Kazuya Morimoto and Manussada Ratanasak and Jun-ya Hasegawa and Masaru Yoshida and Kazuhiko Sato and Yumiko Nakajima}, doi = {10.1002/anie.202416487}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202416487}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-step esterification of phosphoric, phosphonic and phosphinic acids with organosilicates: Phosphorus chemical recycling of sewage waste}, volume = {64}, year = {2025}, }
• (2025). Electrocatalytic micelle-driven hydrodefluorination for accessing unprotected monofluorinated indoles. ANGEW, 64(10), e202416132. (www)

  @article{ , abstract = {Toxic organic solvents and electrolytes, traditionally indispensable for electro-organic synthesis, are now being reconsidered. In developing more sustainable electro-organic synthesis, we've harnessed the aqueous micelles as solvents and electrolyte-like structures when deformed under an electric field. The technology is showcased in synthetically highly valued hydrodefluorination reactions of difluorinated indoles. This mild electrosynthetic method produces monofluorinated unprotected indole scaffolds. Our approach minimizes waste and enhances atom economy, reducing reliance on expensive and hazardous solvents and electrolytes. The surfactant's potential for recycling was verified for two cycles. Cyclic voltammetry analysis has corroborated that PS-750-M micelles in water establish a more efficient platform for hydrodefluorination. Our technology simplifies the production of monofluorinated indoles, which are crucial for many drug-like molecules.}, archive = {J_ANGEW}, author = {Karanjeet Kaur and Raki Mandal and Justin R. Walensky and Fabrice Gallou and Sachin Handa}, doi = {10.1002/anie.202416132}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202416132}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrocatalytic micelle-driven hydrodefluorination for accessing unprotected monofluorinated indoles}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed reductive hydrolysis of nitriles to alcohols. ANGEW, 64(10), e202414689. (www)

  @article{ , abstract = {Nitriles are an abundant class of compounds that are widely used as versatile feedstocks to produce various chemicals including pharmaceuticals, and agrochemicals as well as materials. Here we report Ni-catalyzed reductive hydrolysis of nitriles to alcohols in the presence of molecular hydrogen. This conversion likely occurs in a domino reaction sequence that first involves the hydrogenation of nitrile to primary imine, then the hydrolysis of imine, and subsequent deamination to the aldehyde, which is finally hydrogenated to the desired alcohol. Crucial for this reductive hydrolysis process is the commercially available triphos-ligated Ni-complex that enables highly efficient and selective transformation of aromatic, heterocyclic, and aliphatic nitriles including fatty nitriles to prepare functionalized primary alcohols. Further, the synthetic applicability of this Ni-based protocol is presented for the selective conversion of nitrile to alcoholic group in structurally diverse and complex drug molecules as well as agrochemicals. The resulting products, alcohols are indispensable chemicals commonly used in organic synthesis and life sciences as well as material and energy technologies.}, archive = {J_ANGEW}, author = {Chakreshwara Kuloor and Akash and Vishakha Goyal and Radek Zbořil and Mathias Beller and Rajenahally V. Jagadeesh}, doi = {10.1002/anie.202414689}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202414689}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed reductive hydrolysis of nitriles to alcohols}, volume = {64}, year = {2025}, }
• (2025). Fighting antimicrobial resistance: Innovative drugs in antibacterial research. ANGEW, 64(10), e202414325. (www)

  @article{ , abstract = {In the fight against bacterial infections, particularly those caused by multi-resistant pathogens known as “superbugs”, the need for new antibacterials is undoubted in scientific communities and is by now also widely perceived by the general population. However, the antibacterial research landscape has changed considerably over the past years. With few exceptions, the majority of big pharma companies has left the field and thus, the decline in R&D on antibacterials severely impacts the drug pipeline. In recent years, antibacterial research has increasingly relied on smaller companies or academic research institutions, which mostly have only limited financial resources, to carry a drug discovery and development process from the beginning and through to the beginning of clinical phases. This review formulates the requirements for an antibacterial in regard of targeted pathogens, resistance mechanisms and drug discovery. Strategies are shown for the discovery of new antibacterial structures originating from natural sources, by chemical synthesis and more recently from artificial intelligence approaches. This is complemented by principles for the computer-aided design of antibacterials and the refinement of a lead structure. The second part of the article comprises a compilation of antibacterial molecules classified according to bacterial target structures, e.g. cell wall synthesis, protein synthesis, as well as more recently emerging target classes, e.g. fatty acid synthesis, proteases and membrane proteins. Aspects of the origin, the antibacterial spectrum, resistance and the current development status of the presented drug molecules are highlighted.}, archive = {J_ANGEW}, author = {Roderich D. Süssmuth and Marcel Kulike-Koczula and Peng Gao and Simone Kosol}, doi = {10.1002/anie.202414325}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202414325}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fighting antimicrobial resistance: Innovative drugs in antibacterial research}, volume = {64}, year = {2025}, }
• (2025). Building localized NADP(H) recycling circuits to advance enzyme cascadetronics. ANGEW, 64(10), e202414176. (www)

  @article{ , abstract = {The catalytic action of enzymes in a cascade trapped within a mesoporous electrode material is simultaneously energized, controlled and observed through the efficient, reversible electrochemical NAD(P)(H) recycling catalyzed by one of the enzymes. In their nanoconfined state, nicotinamide cofactors are tightly channeled current carriers, mediating multi-step reactions in either direction (oxidation or reduction) with a rapid response time. By incorporating a hydrogen-borrowing enzyme pair, the internal action of which opposes the external voltage bias driving oxidation or reduction, a reduction process can be performed under overall oxidizing conditions, and vice versa. The power of the method to control and resolve complex metabolic pathways is demonstrated using a non-linear, three-enzyme cascade extended by incorporating a fourth enzyme, urease. The latter generates in situ ammonia, which is enzymatically consumed in a reductive process, but the immediate current response to each addition of urea is observed, unusually, by applying an oxidizing potential. A practical consequence is that enzyme-catalyzed electrochemical reduction reactions requiring anaerobic conditions (to avoid O 2 interference) can readily be studied under ambient aerobic conditions. The results illustrate how a complex enzyme cascade confined within a porous electrode and connected to an electrical power source manifests characteristics associated with electronic circuits.}, archive = {J_ANGEW}, author = {Ryan A. Herold and Christopher J. Schofield and Fraser A. Armstrong}, doi = {10.1002/anie.202414176}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202414176}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Building localized NADP(H) recycling circuits to advance enzyme cascadetronics}, volume = {64}, year = {2025}, }
• (2025). Benzylic C−H radical sulfation by persulfates. ANGEW, 64(10), e202413847. (www)

  @article{ , abstract = {Sulfation is a highly valuable pathological and physiological process, yet it is often underappreciated considering the rather difficult accessibility of organosulfates. O -sulfonation ( O −SO 3 ), a conventional and still common way to make organosulfates, restricts its applicability to hydroxyl compounds and therein lies a major challenge of library construction. Here, we describe a benzylic C−H radical sulfation with persulfates via C−O bond formation. This strategy leverages modular control over the reactivity of persulfates and the stability of sulfate radicals by coutercations. K + /NH 4 + stabilized sulfate radicals act as the oxidant to generate carbon-centered radicals from substrates, and activation of persulfates by n -NBu 4 + provides O−O resource pool to facilitate C−OSO 3 − bond formation via a bimolecular homolytic substitution (S H 2) process.}, archive = {J_ANGEW}, author = {Zhen Xia and Zhongyao Ye and Ting Deng and Ze Tan and Chunlang Song and Jiakun Li}, doi = {10.1002/anie.202413847}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202413847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Benzylic C−H radical sulfation by persulfates}, volume = {64}, year = {2025}, }
• (2025). A highly selective and versatile probe platform for visualization of monoacylglycerol lipase. ANGEW, 64(10), e202413405. (www)

  @article{ , abstract = {Monoacylglycerol lipase (MAGL) is a key enzyme for signal termination in the endocannabinoid system (ECS). MAGL inhibition results in indirect activation of the cannabinoid receptors, which offers unique advantages for the treatment of, e.g., multiple sclerosis, epilepsy, and other neurological disorders. Molecular imaging techniques are valuable tools to overcome the current poor understanding of MAGL's distribution and role in patho- and physiological processes within ECS signaling. Herein, we report the design, synthesis, and validation of highly selective versatile fluorescent and click-chemistry probes for MAGL. Structure-based design combined with a reverse-design approach allowed the development of a structural unit that selectively and effectively recognizes MAGL while offering a versatile platform to attach different fluorophores and further reporter units. In this way, labeled probes with sub-nanomolar potency carrying diverse fluorescent dyes were obtained. Probe affinity and selectivity remained invariant to changes in the fluorophore subunit, showing the remarkable robustness of this platform in delivering tailor-made probes. Highly consistent inhibition across species supports pharmacological model translatability. Extensive profiling and validation in various cellular systems shows the ability of these highly potent and selective probes to elucidate the complex role of MAGL in ECS cellular signaling, inflammatory processes, and disease progression.}, archive = {J_ANGEW}, author = {Axel Hentsch and Mónica Guberman and Silke Radetzki and Sofia Kaushik and Mirjam Huizenga and Jerome Paul and Maria Schippers and Jörg Benz and Bernd Kuhn and Dominik Heer and Andreas Topp and Ludivine Esteves Gloria and Alexander Walter and Remo Hochstrasser and Matthias B. Wittwer and Jens Peter von Kries and Ludovic Collin and Julie Blaising and Mario van der Stelt and Noa Lipstein and Uwe Grether and Marc Nazaré}, doi = {10.1002/anie.202413405}, journal = {Angewandte Chemie International Edition}, month = {3}, number = {10}, pages = {e202413405}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly selective and versatile probe platform for visualization of monoacylglycerol lipase}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Rapid N2O formation from n2 on water droplet surfaces. ANGEW, 64(9), e202580962. (www)

  @article{ , archive = {J_ANGEW}, author = {Qi Jiang and Deming Xia and Xiaofan Li and Hong Zhang and Rujing Yin and Huaijun Xie and Hong-bin Xie and Jie Jiang and Jingwen Chen and Joseph S. Francisco}, doi = {10.1002/anie.202580962}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202580962}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Rapid N2O formation from n2 on water droplet surfaces}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: CO2 reduction at a borane-modified iron complex: A secondary coordination sphere strategy. ANGEW, 64(9), e202580961. (www)

  @article{ , archive = {J_ANGEW}, author = {Connor S. Durfy and Joseph A. Zurakowski and Marcus W. Drover}, doi = {10.1002/anie.202580961}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202580961}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: CO2 reduction at a borane-modified iron complex: A secondary coordination sphere strategy}, volume = {64}, year = {2025}, }
• (2025). Back cover: Single crystalline, non-stoichiometric hydrogen-bonded organic frameworks showing versatile fluorescence depending on composition ratios and distributions (Angew. chem. int. ed. 9/2025). ANGEW, 64(9), e202502492. (www)

  @article{ , archive = {J_ANGEW}, author = {Taito Hashimoto and Mario de la Hoz Tomás and Ryusei Oketani and Boiko Cohen and Miki Naruoka and Norimitsu Tohnai and Abderrazzak Douhal and Ichiro Hisaki}, doi = {10.1002/anie.202502492}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202502492}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Single crystalline, non-stoichiometric hydrogen-bonded organic frameworks showing versatile fluorescence depending on composition ratios and distributions (Angew. chem. int. ed. 9/2025)}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Deciphering polymer interactions in bioconjugates with different architectures by structural analysis via time-resolved limited proteolysis mass spectrometry (Angew. chem. int. ed. 9/2025). ANGEW, 64(9), e202502486. (www)

  @article{ , archive = {J_ANGEW}, author = {Prisca Hamm and Marc D. Driessen and Niklas Hauptstein and Josef Kehrein and Rafael Worschech and Paria Pouyan and Rainer Haag and Ulrich S. Schubert and Thomas D. Müller and Lorenz Meinel and Tessa Lühmann}, doi = {10.1002/anie.202502486}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202502486}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Deciphering polymer interactions in bioconjugates with different architectures by structural analysis via time-resolved limited proteolysis mass spectrometry (Angew. chem. int. ed. 9/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Scalable atomic-layer tailoring of abundant oxide supports unlocks superior interfaces for low-metal-loading dehydrogenation (Angew. chem. int. ed. 9/2025). ANGEW, 64(9), e202502040. (www)

  @article{ , archive = {J_ANGEW}, author = {Yeonsu Kwak and Yu-Jin Lee and Seongeun Moon and Kimoon Lee and Safira Ramadhani and Eui-Rim On and Chang-il Ahn and Son-Jong Hwang and Hyuntae Sohn and Hyangsoo Jeong and Suk Woo Nam and Chang Won Yoon and Yongmin Kim}, doi = {10.1002/anie.202502040}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202502040}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Scalable atomic-layer tailoring of abundant oxide supports unlocks superior interfaces for low-metal-loading dehydrogenation (Angew. chem. int. ed. 9/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Multiple structural and phase transformations of MOF and selective hydrocarbon gas separation in its amorphous, glass phase states (Angew. chem. int. ed. 9/2025). ANGEW, 64(9), e202502039. (www)

  @article{ , archive = {J_ANGEW}, author = {Jian Li and Jia-Xin Wu and Tao Liu and Jian Yang and Mei-Ling Wei and Chuang Yang and Qiubing Dong and Zheng Yin and Mohamedally Kurmoo and Ming-Hua Zeng}, doi = {10.1002/anie.202502039}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202502039}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Multiple structural and phase transformations of MOF and selective hydrocarbon gas separation in its amorphous, glass phase states (Angew. chem. int. ed. 9/2025)}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: Correction to “Chiral isochalcogenourea-catalysed enantioselective (4+2) cycloadditions of allenoates”. ANGEW, 64(9), e202501948. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202501948}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202501948}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: Correction to “Chiral isochalcogenourea-catalysed enantioselective (4+2) cycloadditions of allenoates”}, volume = {64}, year = {2025}, }
• (2025). Marcus w. drover. ANGEW, 64(9), e202501753. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202501753}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202501753}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Marcus w. drover}, volume = {64}, year = {2025}, }
• (2025). Anna wuttig. ANGEW, 64(9), e202501445. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202501445}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202501445}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anna wuttig}, volume = {64}, year = {2025}, }
• (2025). Electrochemical cyclopropanation of unactivated alkenes with methylene compounds. ANGEW, 64(9), e202425634. (www)

  @article{ , abstract = {Cyclopropanes are prevalent in natural products, pharmaceuticals, and bioactive compounds, functioning as a significant structural motif. Although a series of methods have been developed for the construction of the cyclopropane skeleton, the development of a direct and efficient strategy for the rapid synthesis of cyclopropanes from bench-stable starting materials with a broad substrate scope and functional group tolerance remains challenging and highly desirable. Herein, we present an electrochemical method for the direct cyclopropanation of unactivated alkenes using active methylene compounds. The strategy shows a broad substrate scope with a high level of functional group compatibility, as well as potential application as demonstrated by late-stage cyclopropanation of complex molecules and drug derivatives. Further mechanistic investigations suggest that Cp 2 Fe (Fc) plays an essential role as an oxidative mediator in generating radicals from active methylene compounds.}, archive = {J_ANGEW}, author = {Min Liu and Yanwei Wang and Chao Gao and Jingpei Jia and Zile Zhu and Youai Qiu}, doi = {10.1002/anie.202425634}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202425634}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical cyclopropanation of unactivated alkenes with methylene compounds}, volume = {64}, year = {2025}, }
• (2025). Machine learning-guided modulation of li+ solvation structures towards optimal electrolyte systems for high-performance Li−O2 battery. ANGEW, 64(9), e202425277. (www)

  @article{ , abstract = {As the “blood” of Li−O 2 batteries (LOBs), electrolytes with various solvation structures of Li + can greatly influence the composition of solid electrolyte interphase (SEI) on anode and the growth kinetics of Li 2 O 2 on cathode, and further the battery performance. However, achieving delicate modulation of the multi-composition electrolytes remains significantly challenging to simultaneously give consideration to both the anode and cathode reactions. In this work, we employed Bayesian optimization to develop advanced electrolytes for LOBs, enabling the formation of a stable inorganic-rich SEI, and modulation of Li 2 O 2 morphologies. Thus obtained LOBs using the optimized dual-solvent electrolyte could deliver a discharge capacity of 14,063 mAh g −1 at a current density of 500 mA g −1 , which is far higher than those using the single-solvent electrolytes. This study not only highlights the critical role of the solvation structure for improving the battery performance, but also provides new insights and important theoretical guidance for delicate modulation of electrolyte compositions.}, archive = {J_ANGEW}, author = {Dapeng Liu and Zerui Fu and Shu Wang and Xiangrui Gong and Tingting You and Haohan Yu and Ying Jiang and Yu Zhang}, doi = {10.1002/anie.202425277}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202425277}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning-guided modulation of li+ solvation structures towards optimal electrolyte systems for high-performance Li−O2 battery}, volume = {64}, year = {2025}, }
• (2025). Anion transport by bambusuril-bile acid conjugates: Drastic effect of the cholesterol content. ANGEW, 64(9), e202424754. (www)

  @article{ , abstract = {Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.}, archive = {J_ANGEW}, author = {Jacopo Torrisi and Matúš Chvojka and Pia Jurček and Xinxin Zhang and Huaqiang Zeng and Vladimír Šindelář and Hennie Valkenier}, doi = {10.1002/anie.202424754}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202424754}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion transport by bambusuril-bile acid conjugates: Drastic effect of the cholesterol content}, volume = {64}, year = {2025}, }
• (2025). The interplay of methylidyne and carbido species: Modeling a fundamental step in the Fischer–Tropsch synthesis. ANGEW, 64(9), e202424699. (www)

  @article{ , abstract = {Heterobimetallic μ-methylidyne complexes [WPt(μ 2 -CH)(CO) 2 L 2 (Tp*)], where L 2 =(PPh 3 ) 2 , (PPh 3 )(CO), (dppe), (PPh 3 )(CNC 6 H 2 Me 3 ), have been obtained via the intermediacy of transient hydrido-μ-carbido complexes that undergo carbido-hydrido coupling to model a fundamental step in the proposed mechanism for Fischer–Tropsch synthesis.}, archive = {J_ANGEW}, author = {Liam K. Burt and Anthony F. Hill}, doi = {10.1002/anie.202424699}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202424699}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The interplay of methylidyne and carbido species: Modeling a fundamental step in the Fischer–Tropsch synthesis}, volume = {64}, year = {2025}, }
• (2025). Precise tailoring of unprecedent layered perovskite-type heterostructure ferroelectric via chemical molecular scissor. ANGEW, 64(9), e202424279. (www)

  @article{ , abstract = {Precise stacking of distinct two-dimensional (2D) rigid slabs to build heterostructures has renewed the portfolio of 2D materials, e.g., magic-angle graphene, due to the emergence of exotic physical properties. Recently, single-crystal heterostructures of layered perovskites have emerged as an exciting branch, while it remains scarce to achieve strong ferroelectricity in this new heterostructure family. Here, we present the first ferroelectric of 2D perovskite heterostructures as single crystal, (EA 3 Pb 2 Br 7 )EA 4 Pb 3 Br 10 ( 1 , EA=ethylamine), by precisely tailoring inorganic sheets via a chemical molecular scissor. It has notable ferroelectricity of large spontaneous polarization ( P s ~5.0 μC/cm 2 ) and high Curie temperature ( T c ~375 K). Structurally, its inorganic framework adopts a unique 2D heterostructure that contains two different rigid slabs of {EA 3 Pb 2 Br 7 } n and {EA 4 Pb 3 Br 10 } n . This motif is self-assembled by layer-by-layer clipping of rigid prototype sheets, using extra neopentylamine as a molecular chemical scissor. Unlike epitaxial growth, such a molecule-level stacking facilitates the growth of heterostructure single crystals. Combining its strong ferroelectricity and inherent anisotropy, crystal-based device of 1 exhibits an ultrahigh polarized-light sensitivity up to ~37 in self-powered mode, being the highest level of 2D perovskite ferroelectric family. Our work will facilitate the further development of ferroelectric materials for optoelectronic device applications.}, archive = {J_ANGEW}, author = {Yu Ma and Wenjing Li and Yi Liu and Wuqian Guo and Haojie Xu and Liwei Tang and Qingshun Fan and Hao Rong and Junhua Luo and Zhihua Sun}, doi = {10.1002/anie.202424279}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202424279}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise tailoring of unprecedent layered perovskite-type heterostructure ferroelectric via chemical molecular scissor}, volume = {64}, year = {2025}, }
• (2025). Kinetic control of self-assembly pathway in dual dynamic covalent polymeric systems. ANGEW, 64(9), e202424147. (www)

  @article{ , abstract = {Kinetically controlled self-assembly is garnering increasing interest in the field of supramolecular polymers and materials, yet examples involving dynamic covalent exchange remain relatively unexplored. Here we report an unexpected dynamic covalent polymeric system whose aqueous self-assembly pathway is strongly influenced by the kinetics of evaporation of water. The key design is to integrate dual dynamic covalent bonds—including disulfide bonds and boroxine/borate—into a dynamic equilibrium system of monomers, polymers, and materials. This dual dynamic covalent design allows polymer growth and crosslinking to occur with the same spatiotemporal characteristics, governed solely by solvent evaporation. We found that a single building block can assemble into two distinct types of polymeric materials, each characterized by unique crosslinking topologies, orders, solubility, and macroscopic properties. The dual dynamic nature of the materials imparts them with intrinsic reconfigurability, such as interfacial repairability and close-loop chemical recyclability.}, archive = {J_ANGEW}, author = {Ling Liu and Yuanxin Deng and Da-Hui Qu and Ben L. Feringa and He Tian and Qi Zhang}, doi = {10.1002/anie.202424147}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202424147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Kinetic control of self-assembly pathway in dual dynamic covalent polymeric systems}, volume = {64}, year = {2025}, }
• (2025). Design of cell-penetrating domain antibodies via a genetically encoded β-lactam amino acid. ANGEW, 64(9), e202424076. (www)

  @article{ , abstract = {Domain antibodies such as monobodies provide an attractive immunoglobin fold for evolving high-affinity protein binders targeting the intracellular proteins implicated in cell signalling. However, it remains a challenge to endow cell permeability to these small and versatile protein binders. Here, we report a streamlined approach combining orthogonal crosslinking afforded by a genetically encoded β -lactam-lysine (BeLaK) and genetic supercharging to generate cell-penetrating monobodies. When introduced to the N-terminal β -strand of a series of supercharged monobodies, BeLaK enabled efficient inter-strand crosslinking with the neighbouring lysine. Compared to its non-crosslinked counterpart, a BeLaK-crosslinked, +18-charged monobody exhibited enhanced thermostability and greater cellular uptake at 40 nM. Moreover, this structurally rigidified, supercharged monobody inhibited ERK1/2 phosphorylation in KYSE-520 esophageal cancer cell line at sub-micromolar concentration, indicating significant endosomal escape after endocytosis. Together, the discovery of this BeLaK-encoded, rigidified immunoglobin fold should facilitate the design of cell-penetrating monobodies targeting intracellular signalling proteins.}, archive = {J_ANGEW}, author = {Johnathan D. Rabb and Lucas E. Kruse and Qing Lin}, doi = {10.1002/anie.202424076}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202424076}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of cell-penetrating domain antibodies via a genetically encoded β-lactam amino acid}, volume = {64}, year = {2025}, }
• (2025). Late-stage Pd(II)-catalyzed C(sp3)−H functionalization of peptides directed by a removable, backbone-inserted amidoxime ether. ANGEW, 64(9), e202423979. (www)

  @article{ , abstract = {Palladium(II)-catalyzed C−H functionalization has attracted considerable attention as a pathway to late-stage modification of peptides. Herein, we report the Pd-catalyzed C(sp 3 )−H arylation of peptides directed by an amidoxime ether, which can be easily incorporated into peptides at any amide bond. Site- and stereoselective arylation of peptides has been achieved, including unprecedented functionalization of internal residues of native peptides. Removal of the amidoxime ether was achieved to generate the parent amide and facilitate a traceless C−H functionalization process.}, archive = {J_ANGEW}, author = {Yuezhou Wu and Beichen Zhu and Haoyang Fan and Hugo Bernard and Craig A. Hutton}, doi = {10.1002/anie.202423979}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202423979}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Late-stage Pd(II)-catalyzed C(sp3)−H functionalization of peptides directed by a removable, backbone-inserted amidoxime ether}, volume = {64}, year = {2025}, }
• (2025). Secupyritines A-c, three natural propellane securinega alkaloids: Structure elucidation and total synthesis based on biogenetic building blocks. ANGEW, 64(9), e202423900. (www)

  @article{ , abstract = {Secupyritines A-C are unique polycyclic Securinega alkaloids isolated from medicinal plant Flueggea suffruticosa . They feature a distinctive 6/6/6/5/6 fused pentacyclic ring system with a highly strained 2-oxa-6-aza[4.4.3]propellane core. Their structures with absolute configurations were elucidated through a comprehensive approach involving nuclear magnetic resonance (NMR) spectroscopy, single-crystal X-ray crystallography, electronic circular dichroism (ECD) calculations, and total synthesis. The total synthesis of secupyritines A-C was achieved in 14 or 16 steps, employing a synthesis strategy based on biogenetic building blocks. Key elements of the synthetic procedures include a vinylogous Mannich-type reaction to construct the sp 3 -sp 2 attached-ring system, a Suzuki coupling reaction to build the piperidine ring, and an intramolecular aza -Michael addition reaction to establish the propellane skeleton. Formal asymmetric synthesis of secupyritines A-C was also presented.}, archive = {J_ANGEW}, author = {Guan-Qiu Qin and Gui-Yang Wang and Qin-Cheng Shen and Wen-Hua Yu and Jian-Guo Song and Xiao-Jun Huang and Lu Dong and Zhen-Long Wu and Wen-Cai Ye and Li-Jun Hu and Ying Wang}, doi = {10.1002/anie.202423900}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202423900}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Secupyritines A-c, three natural propellane securinega alkaloids: Structure elucidation and total synthesis based on biogenetic building blocks}, volume = {64}, year = {2025}, }
• (2025). A trithia-bridged N-heterotriangulene: The hitherto missing electron donor. ANGEW, 64(9), e202423802. (www)

  @article{ , abstract = {The very first representative of trithia-bridged N -heterotriangulene, a triphenylamine with sulfur atoms bridging the ortho -positions, was synthesized by a sequence of regioselective sulfenylation with phthalimidesulfenyl chloride followed by Lewis acid-catalyzed electrophilic cyclization. X-ray crystallography revealed a saddle-shaped geometry of the polycyclic scaffold. UV/Vis absorption spectroscopy and cyclic voltammetry were used to characterize the optoelectronic properties. The title compound is a particularly strong electron donor forming a perfectly stable radical cation, which was analyzed by electron paramagnetic resonance spectroscopy and X-ray crystallography. The electron donor properties were further highlighted by the formation of crystalline donor-acceptor complexes with strong cyano-based acceptors.}, archive = {J_ANGEW}, author = {Jan Borstelmann and Viktoria Gensch and Dominik Fehn and Matthias E. Miehlich and Frank Hampel and Frank Rominger and Karsten Meyer and Milan Kivala}, doi = {10.1002/anie.202423802}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202423802}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A trithia-bridged N-heterotriangulene: The hitherto missing electron donor}, volume = {64}, year = {2025}, }
• (2025). Enantioselective trifluoromethylazidation of styrenyl olefins catalyzed by an engineered nonheme iron enzyme. ANGEW, 64(9), e202423507. (www)

  @article{ , abstract = {Organofluorines, particularly those containing trifluoromethyl (CF 3 ) groups, play a critical role in medicinal chemistry. While trifluoromethylation of alkenes provides a powerful synthetic route to construct CF 3 -containing compounds with broad structural and functional diversity, achieving enantioselective control in these reactions remains a formidable challenge. In this study, we engineered a nonheme iron enzyme, quercetin 2,3-dioxygenase from Bacillus subtilis ( Bs QueD), for the enantioselective trifluoromethylazidation of alkenes. Through directed evolution, the final variant Bs QueD-CF 3 exhibited excellent enantioselectivity, with an enantiomeric ratio (e.r.) of up to 98 : 2. Preliminary mechanistic studies suggest the involvement of radical intermediates. This work expands biocatalytic organofluorine chemistry by reprogramming metalloenzymes for innovative trifluoromethylation reactions.}, archive = {J_ANGEW}, author = {Hua He and Jia-Xin Yan and Jian-Xiang Zhu and Si-Jia Liu and Xiao-Qi Liu and Peng Chen and Xin Wang and Zhi-Jun Jia}, doi = {10.1002/anie.202423507}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202423507}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective trifluoromethylazidation of styrenyl olefins catalyzed by an engineered nonheme iron enzyme}, volume = {64}, year = {2025}, }
• (2025). Advances in the design of photoactivatable metallodrugs: Excited state metallomics. ANGEW, 64(9), e202423335. (www)

  @article{ , abstract = {Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms of action to combat resistance to current therapy. We highlight recent progress in the design of platinum, ruthenium, iridium, gold and other transition metal complexes, especially for applications as anticancer and anti-infective agents. In particular, understanding excited state chemistry related to identification of the bioactive species (excited state metallomics/pharmacophores) is important. Photoactivatable metallodrugs are classified here as photocatalysts, photorelease agents and ligand-activated agents. Their activation wavelengths, cellular mechanisms of action, experimental and theoretical metallomics of excited states and photoproducts are discussed to explore new strategies for the design and investigation of photoactivatable metallodrugs. These photoactivatable metallodrugs have potential in clinical applications of Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) and Photothermal Therapy (PTT).}, archive = {J_ANGEW}, author = {Huayun Shi and Rafael C. Marchi and Peter J. Sadler}, doi = {10.1002/anie.202423335}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202423335}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Advances in the design of photoactivatable metallodrugs: Excited state metallomics}, volume = {64}, year = {2025}, }
• (2025). Unlocking HFIP for fluoroalkylation with molecular photoelectrocatalysis. ANGEW, 64(9), e202423241. (www)

  @article{ , abstract = {Despite the increasing interest in radical-based fluoroalkylation techniques, the organofluorine compounds bearing the partially fluorinated hexafluoroisopropyl group remain extremely scarce due to the lack of appropriate reagents. Herein we report an unprecedented photoelectrocatalytic method for the C−H hexafluoroisopropylation of indoles and tryptophan peptides, utilizing the readily available hexafluoro-2-propanol (HFIP) as the fluoroalkylation reagent. In this process, HFIP is converted into hexafluoroisopropyl radicals, enabling fluoroalkylation reactions. This study broadens the potential applications of molecular photoelectrocatalysis, highlighting its capacity to enable transformations that are difficult to accomplish through traditional electrochemical or photochemical approaches.}, archive = {J_ANGEW}, author = {Yi-Xian Zheng and Yuxing Gao and Peng Xiong and Hai-Chao Xu}, doi = {10.1002/anie.202423241}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202423241}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking HFIP for fluoroalkylation with molecular photoelectrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Photoinduced late-stage radical decarboxylative and deoxygenative coupling of complex carboxylic acids and their derivatives. ANGEW, 64(9), e202423113. (www)

  @article{ , abstract = {The simple and efficient conversion of carboxylic acids into structurally diverse organic molecules is highly desirable in chemical synthesis. This review covers recent developments in photocatalytic methodology for late-stage transformations of complex carboxylic acids and their derivatives enabled by radical decarboxylation and deoxygenation, highlighting some representative and significant contributions in this field. These advancements are categorized based on the reactivity patterns exhibited by the carboxylic acids. Several activation modes to generate alkyl or aryl radical intermediates during decarboxylation of carboxylic acids are presented, namely, single-electron transfer (SET) oxidation, ligand-to-metal charge transfer (LMCT), SET reduction, and energy transfer (EnT) processes. On the other hand, direct activation of C−O bonds in carboxylic acids mediated by phosphoranyl radicals has been discussed and illustrates their potential synthetic application for the synthesis of complex aldehydes, ketones and amides.}, archive = {J_ANGEW}, author = {Cheng-Long Ji and Yi-Nan Lu and Siyu Xia and Chengjian Zhu and Congqing Zhu and Weipeng Li and Jin Xie}, doi = {10.1002/anie.202423113}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202423113}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoinduced late-stage radical decarboxylative and deoxygenative coupling of complex carboxylic acids and their derivatives}, volume = {64}, year = {2025}, }
• (2025). Photoacids and photobases: Applications in functional dynamic systems. ANGEW, 64(9), e202422963. (www)

  @article{ , abstract = {Brønsted photoacids and photobases are a unique class of molecules that undergo a major change in their p K a values between their ground and excited states, resulting in donating or accepting a proton, respectively, but only after light excitation. This property of photoacids/photobases makes them an attractive tool for light-gating various dynamic processes. Here, we review the use of this property to manipulate functional dynamic systems with light. We discuss how a proton transfer event that can happen upon light excitation from a photoacid to a chemical moiety of a certain system or, vice versa, from the system to a photobase, can result in a shift in the equilibrium of the system, resulting in some dynamicity. We detail various systems, including self-assembly processes of nanostructures, self-propulsion of droplets, catalysis for hydrogen evolution or CO 2 capturing, nanotechnological devices based on enzymatic processes, and changes in proton-conducting ionophores and materials. We detail the basic guidelines for using Brønsted photoacids and photobases in a desired system and conclude with the current technological gaps in further using these molecules.}, archive = {J_ANGEW}, author = {Anna Yucknovsky and Nadav Amdursky}, doi = {10.1002/anie.202422963}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202422963}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoacids and photobases: Applications in functional dynamic systems}, volume = {64}, year = {2025}, }
• (2025). Precise identification of native peptides with posttranslational proline hydroxylation by nanopore. ANGEW, 64(9), e202422692. (www)

  @article{ , abstract = {Hydroxylation, an extensive post-translational modification on proline, is critical for the modulation of native protein structures, further dominating their functions in life systems. However, current mass spectrometry (MS)-based identification, could hardly distinguish hydroxylation with the neighboring oxidation due to the same mass shifts, as well as challenges posed by low abundance and exogenous oxidation during sample preparation. To address this, an engineered nanopore was designed, capable of discriminating single hydroxyl group on proline, to achieve the identification of proline hydroxylation on individual native peptides directly in mixture. By modeling the interaction between hydroxylated proline and its specific recognition protein, we introduced a hydrophobic region in aerolysin lumen with A224Y/T274W mutations to enhance the sensitivity for proline residue. The results showed that the proline hydroxylation on native HIF-1α fragments could be unambiguously identified without purification, which could be maintained even in the presence of neighboring oxidation. The voltage-dependent experiments further demonstrated the more relaxed peptide structure induced by hydroxylation that supported the great impact of hydroxylation on chemical properties of proline and the molecular mechanism of the specific recognition for hydroxylated proline in nature. These findings highlight the potential of nanopore for precise hydroxylation detection, offering a reliable platform for further uncovering the related functions in biological systems.}, archive = {J_ANGEW}, author = {Jing-Wen Chang and Yan Gao and Ai-Hua Zou and Meng-Yin Li and Yi-Tao Long and Jie Jiang}, doi = {10.1002/anie.202422692}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202422692}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise identification of native peptides with posttranslational proline hydroxylation by nanopore}, volume = {64}, year = {2025}, }
• (2025). A regio- and stereoselective ring-opening polymerization approach to isotactic alternating poly(lactic-co-glycolic acid) with stereocomplexation. ANGEW, 64(9), e202422147. (www)

  @article{ , abstract = {Poly(lactic- co -glycolic acid) (PLGA) has been widely employed for various biomedical applications owing to its biodegradability and biocompatibility. The discovery of the stereocomplex formation between enantiomeric alternating PLGA pairs underscored its potential as high-performance biodegradable materials with diverse material properties and biodegradability. Herein, we have established a regio- and stereoselective ring-opening polymerization approach for the synthesis of stereocomplexed isoenriched alternating PLGA from racemic methyl-glycolide ( rac -MG). The high sequence and tacticity control was accomplished by an optimized enantiopure scandium catalyst bearing a spiro-salen scaffold. Varying polymer stereoregularity P m from 0.4 to 0.91 led to a transformation of the resulting alternating PLGA from amorphous to semicrystalline materials. Notably, the stereocomplexed alternating PLGA demonstrated enhanced melting transition temperature ( T m up to 191 °C) and crystallization rate. This regio- and stereocontrolled polymerization represented a versatile approach for the preparation of high-performance biodegradable PLGA materials.}, archive = {J_ANGEW}, author = {Yu-Ting Huang and Hao-Yi Huang and Jing-Liang Cheng and Min Xie and Liang-Wen Feng and Zhongzheng Cai and Jian-Bo Zhu}, doi = {10.1002/anie.202422147}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202422147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A regio- and stereoselective ring-opening polymerization approach to isotactic alternating poly(lactic-co-glycolic acid) with stereocomplexation}, volume = {64}, year = {2025}, }
• (2025). Identification of oligosaccharide isomers using electrostatically asymmetric OmpF nanopore. ANGEW, 64(9), e202422118. (www)

  @article{ , abstract = {Glycans, unlike uniformly charged DNA and compositionally diverse peptides, are typically uncharged and possess rich stereoisomeric diversity in the glycosidic bonds between two monosaccharide units. These unique features, including charge heterogeneity and structural complexity, pose significant challenges for accurate analysis. Herein, we developed a novel single-molecule oligosaccharide sensor, OmpF nanopore. The natural electroosmotic flow within OmpF generates a robust driving force for unlabeled neutral oligosaccharides, enabling detection at a concentration as low as 6.4 μ M. Furthermore, the asymmetric constriction zone of OmpF was employed to construct a stereoselective recognition site, enabling sensitive identification of glycosidic bond differences in cell lysate samples. With the assistance of machine learning algorithms, the OmpF nanopore achieved a recognition accuracy of 99.9 % for tetrasaccharides differing in only one glycosidic bond was achieved. This nanopore sensor provides a highly sensitive analytical tool with a broad dynamic range. It enables chiral recognition of oligosaccharides at low concentrations and is suitable for analysing both low-abundance and practical samples.}, archive = {J_ANGEW}, author = {Fan Gao and Jia-Hong Wang and Hui Ma and Bingqing Xia and Liuqing Wen and Yi-Tao Long and Yi-Lun Ying}, doi = {10.1002/anie.202422118}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202422118}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identification of oligosaccharide isomers using electrostatically asymmetric OmpF nanopore}, volume = {64}, year = {2025}, }
• (2025). CO2 reduction at a borane-modified iron complex: A secondary coordination sphere strategy. ANGEW, 64(9), e202421599. (www)

  @article{ , abstract = {This work addresses fundamental questions that deepen our understanding of secondary coordination sphere effects on carbon dioxide (CO 2 ) reduction using derivatized hydride analogues of the type, [Cp*Fe(diphosphine)H] (Cp* = C 5 Me 5 − ) – a well-studied family of organometallic complex – as models. More precisely, we describe the general reactivity of [(Cp*-BR 2 )Fe(diphosphine)H], which contains an intramolecularly positioned Lewis acid, and its cooperative reactivity with CO 2 . Control experiments underscore the critical nature of borane incorporation for transforming CO 2 to reduced products, a reaction that does not occur for unfunctionalized [Cp*Fe(diphosphine)H]. Additional experiments highlight relevance of borane hybridization and substituent effects. Mechanistic studies performed in the presence and absence of CO 2 emphasize the significance of carbonyl substrate to catalyst longevity. Lessons from these reactions were also transferable – with such borane-containing complexes enabling the chemoselective reduction of aldehydes in the presence of alkenes. These findings provide valuable insights into metal-ligand cooperative design strategies for carbonyl reduction and illustrate the versatility of intramolecularly positioned Lewis acids for otherwise challenging chemical transformations.}, archive = {J_ANGEW}, author = {Connor S. Durfy and Joseph A. Zurakowski and Marcus W. Drover}, doi = {10.1002/anie.202421599}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202421599}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CO2 reduction at a borane-modified iron complex: A secondary coordination sphere strategy}, volume = {64}, year = {2025}, }
• (2025). Rapid N2O formation from n2 on water droplet surfaces. ANGEW, 64(9), e202421002. (www)

  @article{ , abstract = {Nitrogen (N 2 ) has long been considered as stable atmospheric reservoir for N element and has a persistence time of hundreds of years. This study reveals that oxygen (O 2 ) at typical tropospheric concentrations can rapidly activate N 2 , leading to substantial production of nitrous oxide (N 2 O), the third most impactful greenhouse gas, at rates approaching 2.83±0.41 ppmv hour −1 catalyzed by ubiquitous water droplets in experimental systems. Notably, ozone (O 3 ), typically consumed by N 2 O in the stratosphere, can further accelerate N 2 O formation. In contrast, the produced N 2 O concentration is below detection limits in the absence of O 2 /O 3 or water droplets. A novel reduction-then-oxidation (RTO) mechanism was proposed to account for the rapid formation of N 2 O on the water droplet surfaces facilitated by the cooperation of water droplets and O 2 /O 3 . Further extrapolation indicates that the RTO pathway contributes several Tg N N 2 O annually, far exceeding the most known sources of N 2 O. These findings have broad implications for tracing atmospheric N 2 O sources, enhancing understanding of climate-O 2 /O 3 interactions, and paving avenues for developing new methodologies for N 2 O synthesis.}, archive = {J_ANGEW}, author = {Qi Jiang and Deming Xia and Xiaofan Li and Hong Zhang and Rujing Yin and Huaijun Xie and Hong-bin Xie and Jie Jiang and Jingwen Chen and Joseph S. Francisco}, doi = {10.1002/anie.202421002}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202421002}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid N2O formation from n2 on water droplet surfaces}, volume = {64}, year = {2025}, }
• (2025). Promoting alcohols electrooxidation coupled with hydrogen production via asymmetric pulse potential strategy. ANGEW, 64(9), e202420992. (www)

  @article{ , abstract = {Electrocatalytic organic oxidation coupled with hydrogen (H 2 ) production emerges as a profitable solution to simultaneously reduce overall energy consumption of H 2 production and synthetic high-value chemicals. Noble metal catalysts are highly efficient electrocatalysts in oxidation reactions, but they deactivate easily weakening the benefit in actual production. Herein, we report a universal asymmetric pulse potential strategy to achieve long-term stable operation of noble metals for various alcohol oxidation reactions and noble metal catalysts. For example, by pulsed potentials between 0.8 V and 0 V vs. RHE, palladium (Pd)-catalyzed glycerol (GLY) electrooxidation can continuously proceed for more than 2800 h with glyceric acid (GLA) selectivity of >70 %. Whereas, Pd electrocatalyst becomes nearly deactivated within 6 h of reaction under conventional potentiostatic strategy. Experimental and theoretical calculation results reveal that the generated electrophilic OH* from H 2 O/OH − oxidation on Pd (denoted as Pd−OH*) acts as main active species for GLY oxidation. However, Pd−OH* is prone to be oxidized to PdO x resulting in performance decay. When a short reduction potential (e.g., 0 V vs. RHE for 5 s) is powered, PdO x can be reversibly reduced to restore the current. Moreover, we tested the feasibility of this strategy in a flow electrolyzer, verifying the practical application potential.}, archive = {J_ANGEW}, author = {Tian Xia and Jiangrong Yang and Qinghui Ren and Yu Fu and Zhiyuan Zhang and Zhenhua Li and Mingfei Shao and Xue Duan}, doi = {10.1002/anie.202420992}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420992}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting alcohols electrooxidation coupled with hydrogen production via asymmetric pulse potential strategy}, volume = {64}, year = {2025}, }
• (2025). Intramolecular charge transfer in antiaromatic Donor/Acceptor-fused s-indacenes. ANGEW, 64(9), e202420989. (www)

  @article{ , abstract = {Herein we report the synthesis and characterization of four donor/acceptor-fused s -indacenes via the late-stage oxidation of a family of unsymmetrical benzofuran/benzothiophene- s -indacene regioisomers. A thorough study of their properties through experimental and computational analysis has revealed the effect of asymmetry on the molecular properties associated with antiaromaticity, as well as a strong correlation between antiaromaticity and intramolecular charge transfer (ICT). The strength of the charge transfer depends on the fusion orientation of the donor and acceptor motifs relative to the s -indacene core. The two most antiaromatic oxidized isomers exhibit strong evidence of ICT with 30 and 40 nm solvatochromic shifts.}, archive = {J_ANGEW}, author = {Isabella S. Demachkie and Michael P. Miller and Gabrielle I. Warren and Joshua E. Barker and Eric T. Strand and Lev N. Zakharov and Michael M. Haley}, doi = {10.1002/anie.202420989}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420989}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intramolecular charge transfer in antiaromatic Donor/Acceptor-fused s-indacenes}, volume = {64}, year = {2025}, }
• (2025). A lithiophilic Donor–Acceptor polymer modified separator for high-performance lithium metal batteries. ANGEW, 64(9), e202420973. (www)

  @article{ , abstract = {As traditional lithium-ion batteries near their theoretical limits, the advancement of lithium-metal batteries (LMBs) becomes crucial for achieving higher energy densities. However, uncontrolled ion transport and unstable solid electrolyte interface (SEI) layer are key factors inducing lithium dendrite growth, hindering the development of LMBs. Separator modification is an effective strategy to address the challenges of LMBs. To tackle the issues, a donor–acceptor polymer (ArMT) consisting of benzene rings and triazine was successfully synthesized and modified onto commercial polypropylene (ArMT@PP) as separators for LMBs. Benefitting from the highly lithiophilic triazine organic units, this ArMT exhibits affinity towards Li + and simplifies the solvation structure of Li + during the diffusion process, thus decreasing the ion diffusion activation energy, thereby accelerating the migration of Li + . Furthermore, triazine organic units with appropriate pore size regulate the plating/stripping behavior of lithium metal anodes, thereby facilitating the formation of a stable solid electrolyte interface (SEI) layer. As a result, the assembled Li|ArMT@PP|Li symmetric cells exhibit stable plating/stripping over 800 h. Moreover, the LiFePO 4 |ArMT@PP|Li cells achieved excellent cycling stability with 127.3 mAh g −1 after 1200 cycles at 1 C and a high capacity retention of 90.58 %. This design strategy ensures a durable and dendrite-free anode and paves the way for the development of high-energy-density LMBs.}, archive = {J_ANGEW}, author = {Tao Yang and Xijun Xu and Suping Chen and Yan Yang and Fangkun Li and Weizhen Fan and Yanxue Wu and Jingwei Zhao and Jun Liu and Yanping Huo}, doi = {10.1002/anie.202420973}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A lithiophilic Donor–Acceptor polymer modified separator for high-performance lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). New thermoplastic elastomers based on ethylene-butadiene-rubber (EBR) by switching from anionic to coordinative chain transfer polymerization. ANGEW, 64(9), e202420946. (www)

  @article{ , abstract = {Olefin triblock copolymers based on glassy polystyrene (PS), ethylene butadiene rubber (EBR) and highly crystalline polyethylene (PE) segments were prepared for the first time using a switch strategy from anionic polymerization to coordinative chain transfer (co)polymerization (CCT(co)P). PS chains obtained by anionic polymerization were transmetalated with mesitylmagnesium bromide (BrMgMes) to act as macromolecular chain transfer agents (macro-CTA, PS-MgMes) in the CCTcoP of ethylene and butadiene using {Me 2 Si(C 13 H 8 ) 2 Nd(BH 4 ) 2 Li(THF)} 2 complex ( 1 ). Further chain extension by CCTP using pure ethylene in the monomer feed afforded well-defined PS- b -EBR- b -PE triblock copolymers. The structural, rheological and mechanical properties of these materials demonstrate excellent balance between properties and easy processability at moderate temperatures (>150 °C). We demonstrate that such triblock copolymers behave effectively as low-viscosity PS- b -EBR diblock copolymers above the melting point of PE domains and high performance thermoplastic elastomers (TPEs) upon crystallization of PE segments.}, archive = {J_ANGEW}, author = {Samy Alioui and Marvin Langlais and Robert Ngo and Karima Habhab and Séverin Dronet and François Jean-Baptiste-dit-Dominique and David Albertini and Franck D'Agosto and Christophe Boisson and Damien Montarnal}, doi = {10.1002/anie.202420946}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420946}, shortjournal = {Angew. Chem. Int. Edit.}, title = {New thermoplastic elastomers based on ethylene-butadiene-rubber (EBR) by switching from anionic to coordinative chain transfer polymerization}, volume = {64}, year = {2025}, }
• (2025). Charge manipulation of porous coordination cages tunes the efficiency and selectivity in electrochemical synthesis. ANGEW, 64(9), e202420945. (www)

  @article{ , abstract = {Electrocatalytic synthesis of high-value chemicals has been attracting growing interest owing to its environmentally benign reaction pathways. Among these processes, the electrocatalytic reduction of nitrate (NO 3 − ) to ammonia (NH 3 ), known as NO 3 RR, and the oxidation of 5-hydroxymethylfurfural (HMFOR) stand out as two cornerstone reactions; yet, their efficiency and selectivity pose ongoing challenges. In this study, we introduce a charge manipulation approach for the design of highly efficient electrocatalysts tailored for the simultaneous coupling of NO 3 RR and HMFOR. We have synthesized a range of porous coordination cages (PCCs) that share the same topology and Co/Ni metal centers but incorporate different charged moieties, imparting them with distinct surface net charges. Electrocatalytic evaluations revealed that PCC-Co demonstrated a voltage-dependent activity in NO 3 RR. Conversely, PCC-Ni exhibited a precisely adjustable product selectivity in HMFOR, contingent upon the cage‘s charge state. In situ analysis and Density functional theory (DFT) calculations underscored the profound impact of catalyst charge on the differential adsorption of reaction intermediates and the lowest free energy change (ΔG) during the pivotal reaction step, resulting in alterations to both activity and selectivity. These discoveries provide invaluable insights into the “structure-performance relationship” of NO 3 RR/HMFOR catalysts, highlighting PCCs as promising contenders for advanced electrocatalysts.}, archive = {J_ANGEW}, author = {Zhifang Su and Kang-Kai Liu and Yu-Qi Xu and Bing Yan and Shuangyin Wang and Zong-Jie Guan and Yuqin Zou and Yu Fang}, doi = {10.1002/anie.202420945}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420945}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Charge manipulation of porous coordination cages tunes the efficiency and selectivity in electrochemical synthesis}, volume = {64}, year = {2025}, }
• (2025). Active hydroxyl-mediated preferential cleavage of carbon-carbon bonds in electrocatalytic glycerol oxidation. ANGEW, 64(9), e202420942. (www)

  @article{ , abstract = {Electrocatalytic glycerol oxidation reaction (GOR) to produce high-value formic acid (FA) is hindered by high formation potential of active species and sluggish C−C bond cleavage kinetics. Herein, Ni single-atom (Ni SA ) and Co single-atom (Co SA ) dual sites anchored on nitrogen-doped carbon nanotubes embedded with Ni 0.1 Co 0.9 alloy (Ni 0.1 Co 0.9 @Ni SA Co SA -NCNTs) are constructed for electrochemical GOR. Remarkably, it can reach 10 mA cm −2 at a low potential of 1.15 V versus the reversible hydrogen electrode (vs. RHE) and realize a high formate selectivity of 93.27 % even at high glycerol conversion of 98.81 % at 1.45 V vs. RHE. The GOR mechanism and pathway are systematically elucidated via experimental analyses and theoretical calculations. It is revealed that the active hydroxyl (*OH) can be produced during the GOR. The Ni SA , Co SA , and Ni 0.1 Co 0.9 synergistically optimizes the electronic structure of Co SA active sites, reducing the energy barriers of *OH-mediated cleavage of C−C bonds and dehydrogenation of C 1 intermediates. This decreases the number of reaction intermediates and reaction steps of GOR-to-FA, thus increasing the formate production efficiency. After coupling GOR with hydrogen evolution reaction in a membrane electrode assembly cell, 14.26 g of formate and 23.10 L of H 2 are produced at 100 mA cm −2 for 108 h.}, archive = {J_ANGEW}, author = {Qiang Zhang and Xiaojing Zhang and Baocang Liu and Peng Jing and Xuan Xu and Haigang Hao and Rui Gao and Jun Zhang}, doi = {10.1002/anie.202420942}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420942}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Active hydroxyl-mediated preferential cleavage of carbon-carbon bonds in electrocatalytic glycerol oxidation}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed regioselective and enantioselective hydropyridylation of dienes for the synthesis of chiral diaryl compounds via concerted nucleophilic aromatic substitution. ANGEW, 64(9), e202420918. (www)

  @article{ , abstract = {The synthesis of chiral 1,1-diaryl compounds, particularly those containing a pyridine moiety, is of significant interest due to their pharmaceutical applications. Here, we report the development of a copper-catalyzed enantioselective 1,4-hydropyridylation of conjugated dienes. Utilizing 2-fluoropyridine as the electrophile, CuOAc, and the chiral ligand Tol-BINAP, we optimized reaction conditions to achieve the desired chiral 1,1-diaryl products containing both a pyridine and a cis-crotyl group. Mechanistic studies and DFT calculations revealed that the 1,2-hydrocupration step is enantio-determining, and the concerted nucleophilic aromatic substitution proceeds via six-membered cyclic transition states.}, archive = {J_ANGEW}, author = {Minjeong Seo and Sanghyup Seo and Joonho Jung and Hyunwoo Kim}, doi = {10.1002/anie.202420918}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420918}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed regioselective and enantioselective hydropyridylation of dienes for the synthesis of chiral diaryl compounds via concerted nucleophilic aromatic substitution}, volume = {64}, year = {2025}, }
• (2025). Decoupling h2 and o2 release in particulate photocatalytic overall water splitting using a reversible o2 binder. ANGEW, 64(9), e202420913. (www)

  @article{ , abstract = {H 2 and O 2 evolutions occur simultaneously for conventional particulate photocatalytic overall water splitting (PPOWS), leading to a significant backward reaction and the formation of an explosive H 2 /O 2 gas mixture. This is an issue that must be addressed prior to industrialization of PPOWS. Here, a convenient, cost-effective, and scalable concept is introduced to uncouple hydrogen and oxygen production for PPOWS. Based on this idea, a three-component photocatalyst, Co(5 %)-HPCN/(rGO/Pt), is constructed, consisting of a photoresponsive chip (HPCN), a H 2 evolution cocatalyst (rGO/Pt), and a cobalt complex capable of reversibly binding O 2 (Co), to achieve the decoupling of PPOWS under alternating UV and visible light irradiations. The asynchronous O 2 and H 2 evolution strategy have considerable flexibility regarding the photocatalyst structure and light sources suitable for PPOWS.}, archive = {J_ANGEW}, author = {Dan Liu and Huihui Xu and Jinni Shen and Xun Wang and Chengwei Qiu and Huaxiang Lin and Jinlin Long and Ying Wang and Wenxin Dai and Yuanxing Fang and Yanhui Yang and Xuxu Wang and Xianzhi Fu and Zizhong Zhang}, doi = {10.1002/anie.202420913}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Decoupling h2 and o2 release in particulate photocatalytic overall water splitting using a reversible o2 binder}, volume = {64}, year = {2025}, }
• (2025). Boosting one- and two-photon excited fluorescence of interpenetrated tetraphenylethene-based Metal–Organic frameworks (TPE-MOFs) by linker installation. ANGEW, 64(9), e202420912. (www)

  @article{ , abstract = {Immobilizing organic chromophores within the rigid framework of metal-organic frameworks (MOFs) augments fluorescence by effectively curtailing molecular motions. Yet, the substantial interspaces and free volumes inherent to MOFs can undermine photoluminescence efficiency, as they partially constrain intramolecular dynamics. In this study, we achieved optimization of both one- and two-photon excited fluorescence by incorporating linkers into an interpenetrated tetraphenylethene-based MOF (TPE-MOF). This linker installation strategy enables fine-tuning of both crystal packing density and ligand conformations. Strikingly, the desolvated MOFs exhibit remarkable two-photon absorption (TPA) cross-sections, reaching an impressive 8801 GM. Consequently, these materials demonstrate exceptional performance in one- and two-photon excited cellular imaging of HepG2 cells. Our work introduces an innovative approach to enhancing two-photon excited fluorescence (TPEF) and broadens the scope of research into one- and two-photon excited fluorescence (1/2 PEF).}, archive = {J_ANGEW}, author = {Huihui He and Ji Li and Jiayi Zhuang and Jinyi Huang and Yuxuan Meng and Xi Lin and Zhangwen Wei and Liangliang Zhang and Yu Fang and Mei Pan}, doi = {10.1002/anie.202420912}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420912}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting one- and two-photon excited fluorescence of interpenetrated tetraphenylethene-based Metal–Organic frameworks (TPE-MOFs) by linker installation}, volume = {64}, year = {2025}, }
• (2025). Selenium-deficient FeSe2/Fe3O4 electrocatalyst for nitrate reduction to ammonia. ANGEW, 64(9), e202420903. (www)

  @article{ , abstract = {Electrocatalytic reduction of NO 3 − is a green and sustainable method that not only helps to treat industrial pollutants in wastewater, but also produces valuable chemicals. However, the slow dynamics of the proton-coupled electron transfer process results in a high barrier and low conversion efficiency. In this work, the Se-deficient FeSe 2 /Fe 3 O 4 heterojunction was synthesized, which showed excellent electrochemical performance in 0.1 M nitrate reduction reaction, superior to most currently reported catalysts. The high activity of Se-deficient FeSe 2 /Fe 3 O 4 is due to the synergistic effect between FeSe 2 and Fe 3 O 4 to achieve relay catalytic NO 3 − reduction. Among them, the Se-deficient FeSe 2 contributes to NO 3 − deoxygenation and subsequent hydrogenation, and Fe 3 O 4 promotes H 2 O decomposition to provide H proton, jointly promote NO 3 RR. Finally, the online differential electrochemical mass spectra (DEMS), in situ Raman and DFT calculation confirmed the optimal pathway for NO 3 RR to NH 3 on Se-deficient FeSe 2 /Fe 3 O 4 (100). This strategy of relay catalysis provides a potential way to treat wastewater with high concentration nitrate.}, archive = {J_ANGEW}, author = {Yue Du and Haijiao Lu and Jinting Wu and Yalong Zou and Zhen-Feng Huang and Ji-Jun Zou and Tiansheng Mu and Jian Gao and Xiao-Dong Zhu and Yong-Chao Zhang}, doi = {10.1002/anie.202420903}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420903}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selenium-deficient FeSe2/Fe3O4 electrocatalyst for nitrate reduction to ammonia}, volume = {64}, year = {2025}, }
• (2025). Non-radical mediated photocatalytic H2O2 synthesis in conjugate-enhanced phenolic resins with ultrafast charge separation. ANGEW, 64(9), e202420895. (www)

  @article{ , abstract = {It is essential for the development of highly efficient polymeric photocatalysts for hydrogen peroxide (H 2 O 2 ) production. Nevertheless, the non-uniform molecular structures and sluggish reaction pathway of polymeric photocatalysts lead to low conversion efficiency. In this work, we report sulfur-contained phenolic resins with regulated conjugation for photocatalytic H 2 O 2 production. Due to the substitution of sulfur for methylene in the phenolic resin structure, the conjugation degree of the material is adjusted, resulting in the formation of a built-in electric field. This effectively enhances the charge separation capability, enabling charge carriers to react faster with substrates. Through in situ characterization and theoretical calculations, we have unveiled that the introduction of sulfur can modulate the reaction pathway of phenolic resin materials, enabling a dual-pathway photocatalytic H 2 O 2 production mediated by non-radical species. Impressively, the sulfur-contained resin photocatalyst showcases exceptional H 2 O 2 production activity with a solar-to-chemical conversion efficiency of 1.4 % exceeding most reported systems, and generates 25 mmol m −2 of H 2 O 2 under natural sunlight through large-scale equipment. This work provides a facile strategy to separate the photogenerated electron–hole pairs of polymer photocatalysts to achieve efficient artificial photosynthesis.}, archive = {J_ANGEW}, author = {Chen Zhao and Haitao Li and Yanfeng Yin and Wenming Tian and Xiaodan Yan and Jinlu He and Zhian Chen and Sheng Ye and Jian Liu}, doi = {10.1002/anie.202420895}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420895}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-radical mediated photocatalytic H2O2 synthesis in conjugate-enhanced phenolic resins with ultrafast charge separation}, volume = {64}, year = {2025}, }
• (2025). Alloying strategy regulating size and electronic structure of Mo0.25Nb0.75Se2 to achieve high-performance Lithium−Sulfur batteries. ANGEW, 64(9), e202420866. (www)

  @article{ , abstract = {The utilization of catalysts in lithium−-sulfur batteries has proven to be an efficacious avenue for enhancing the kinetics of polysulfide conversion. Specially, the size and electronic structure of catalysts play a pivotal role in harnessing the active sites and intrinsic catalysis activity. Outstanding MoSe 2 and NbSe 2 are were selected from 16 universal transition metal selenides based on the proposed binary descriptor. Then, an alloying strategy is was devised to prepare Mo 0.25 Nb 0.75 Se 2 flakelets for further improvement of the intrinsic catalysis. The integration of density functional theory calculations and electrochemical analysis demonstrates that alloying Mo with Nb can regulate the surface energy and indexes of band match and lattice mismatch, thereby enabling Mo 0.25 Nb 0.75 Se 2 to possess a small size, suitable adsorption energy and low reaction energy barrier. This optimization enhances the catalysis of sulfur reduction/evolution reaction and the reversible deposition/stripping of lithium. Consequently, an assembled Ah-level pouch cell is realized with dramatic cycle stability. With the electrolyte/sulfur ratio of 2.36 μL mg S −1 , the cell can deliver a high energy density of up to 505.4 Wh kg total −1 . This work pioneers a universal strategy for sculpting the geometric configurations and electronic structures of catalysts, to achieve enhanced catalytic activity and precise interpretation of structure–activity relationships.}, archive = {J_ANGEW}, author = {Jia Yuan and Peng Wang and Ning Song and Yu Wang and Jizhen Ma and Shenglin Xiong and Xiaogang Li and Jinkui Feng and Baojuan Xi}, doi = {10.1002/anie.202420866}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420866}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alloying strategy regulating size and electronic structure of Mo0.25Nb0.75Se2 to achieve high-performance Lithium−Sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Chloride residues in RuO2 catalysts enhance its stability and efficiency for acidic oxygen evolution reaction. ANGEW, 64(9), e202420860. (www)

  @article{ , abstract = {. Ruthenium dioxide (RuO 2 ) is a benchmark electrocatalyst for proton exchange membrane water electrolyzers (PEMWE), but its stability during the oxygen evolution reaction (OER) is often compromised by lattice oxygen involvement and metal dissolution. Despite that the typical synthesis of RuO 2 produces chloride residues, the underlying function of chloride have not well investigated. In this study, we synthesized chlorine-containing RuO 2 (RuO 2 -Cl) and pure RuO 2 catalysts with similar morphology and crystallinity. RuO 2 -Cl demonstrated superior stability, three times greater than that of pure RuO 2 , and a lower overpotential of 176 mV at 10 mA cm −2 . Furthermore, the RuO 2 -Cl catalysts that were in situ synthesized on a platinum-coated titanium felt could maintain high performance for up to 1200 hours at 100 mA cm −2 . Computational and experimental analyses show that chloride stabilizes RuO 2 by substituting the bridging oxygen atoms, which subsequently inhibits lattice oxygen evolution and Ru demetallation. Notably, this substitution also lowers the energy barrier of the rate-determining step by strengthening the binding of *OOH intermediates. These findings offer new insights into the previously unknown role of chloride residues and how to improve RuO 2 stability.}, archive = {J_ANGEW}, author = {Jiadong Chen and Menghui Qi and Yun Yang and Xiaofen Xiao and Ying Li and Huile Jin and Yong Wang}, doi = {10.1002/anie.202420860}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420860}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chloride residues in RuO2 catalysts enhance its stability and efficiency for acidic oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Diverse synthesis of arene-fused [n.1.1]-bridged molecules via catalytic cycloaddition and rearrangement reactions. ANGEW, 64(9), e202420831. (www)

  @article{ , abstract = {Although great advancement has been made in synthesis of 3D bridged bicyclic[n.1.1]-bioisosteres, facile construction of 2D/3D merged molecules incorporating bridged rings, as novel chemical space in drug discovery, remains a significant challenge. Herein a collective, selective, and diversity-oriented approach for up to 6 types of 2D/3D polycyclic scaffolds featuring bicyclo[n.1.1] substructure is reported. A boronyl radical-catalyzed [2σ+2π] cycloaddition between bicyclo[1.1.0]butanes and ortho -quinone methides afforded spirocyclic compounds containing a bicyclo[2.1.1]hexanes unit, which were used as intermediates for synthesis of three types of 2D/3D scaffolds via judiciously controlled Lewis acid-catalyzed rearrangements. The reaction and rearrangement of para -quinone methides worked analogously and provided another two polycyclic scaffolds.}, archive = {J_ANGEW}, author = {Tao Yu and Xue Zhao and Zaicheng Nie and Lulu Qin and Zhengwei Ding and Liang Xu and Pengfei Li}, doi = {10.1002/anie.202420831}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420831}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diverse synthesis of arene-fused [n.1.1]-bridged molecules via catalytic cycloaddition and rearrangement reactions}, volume = {64}, year = {2025}, }
• (2025). Adjacent-ligand tuning of atomically precise Cu−Pd sites enables efficient methanol electrooxidation with a CO-free pathway. ANGEW, 64(9), e202420817. (www)

  @article{ , abstract = {Whether the catalyst can realize the non-CO pathway is the key to greatly improve the catalytic activity and stability of methanol oxidation reaction (MOR). It is feasible to optimize the reaction path selectivity by modifying organic ligands and constructing single-atom systems. At the same time, heterogeneous metal nanosheets with atomic thickness have been shown to significantly enhance the catalytic activity of materials due to their ultra-high exposure of active sites and synergistic effects. Herein, we synthesize an ultra-thin heterogeneous alloy metallene with organic ligand-modified surface Cu single atom by one-pot wet chemical method, and further construct an efficient Cu−Pd active sites. The prepared octanoic acid ligand modified PdCu single-atom alloys metallene (SAA OA−Cu-Pdene) shows excellent catalytic activity and stability, with mass activity up to 5.64 A mg Pd −1 and electrochemical active surface area (ECSA) up to 160.39 m 2 g Pd −1 . Structural characterization and in situ experiment jointly indicate that ligand modulation brings about charge transfer, and the accompanying rapid migration of OH − greatly improves the selectivity of non-CO pathways while improving the catalytic activity. The results highlight the importance of adjacent-ligand regulation and provide a new strategy for the design of MOR catalysts with high selectivity of non-CO pathway.}, archive = {J_ANGEW}, author = {Yuanlong Qin and Kedi Yu and Guo Wang and Zechao Zhuang and Yuhai Dou and Dingsheng Wang and Zhengbo Chen}, doi = {10.1002/anie.202420817}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420817}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Adjacent-ligand tuning of atomically precise Cu−Pd sites enables efficient methanol electrooxidation with a CO-free pathway}, volume = {64}, year = {2025}, }
• (2025). A 17.73 % solar-to-hydrogen efficiency with durably active catalyst in stable photovoltaic-electrolysis seawater system. ANGEW, 64(9), e202420814. (www)

  @article{ , abstract = {Developing durably active catalysts to tackle harsh voltage polarization and seawater corrosion is pivotal for efficient solar-to-hydrogen (STH) conversion, yet remains a challenge. We report a durably active catalyst of NiCr-layered double hydroxide (Ru lds NiCr-LDH) with highly exposed Ni−O−Ru units, in which low-loading Ru (0.32 wt %) is locked precisely at defect lattice site (Ru lds ) by Ni and Cr. The Cr site electron equilibrium reservoir and Cl − repulsion by intercalated CO 3 2− ensure the highly durable activity of Ni−O−Ru units. The Ru lds NiCr-LDH‖Ru lds NiCr-LDH electrolyzer based on anion exchange membrane water electrolysis (AEM-WE) shows ultrastable seawater electrolysis at 1000 mA cm −2 . Employing Ru lds NiCr-LDH both as anode and cathode, a photovoltaic-electrolysis seawater system achieves a 17.73 % STH efficiency, corresponding photovoltaic-to-hydrogen (PVTH) efficiency is 72.37 %. Further, we elucidate the dynamic evolutionary mechanism involving the interfacial water dissociation-oxidation, establishing the correlation between the dynamic behavior of interfacial water with the kinetics, activity of Ru lds NiCr-LDH catalytic water electrolysis. Our work is a breakthrough step for achieving economically scalable production of green hydrogen.}, archive = {J_ANGEW}, author = {Yong Gao and Yunyun Xu and Hu Guo and Jingjing Li and Lingling Ding and Tao Wang and Jianping He and Kun Chang and Zhong-Shuai Wu}, doi = {10.1002/anie.202420814}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420814}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A 17.73 % solar-to-hydrogen efficiency with durably active catalyst in stable photovoltaic-electrolysis seawater system}, volume = {64}, year = {2025}, }
• (2025). Unconventional heterobidentate coordination of 4-hydroxypyridine leading to remarkably strong second-harmonic generation in Zn(C5H4NO)2. ANGEW, 64(9), e202420810. (www)

  @article{ , abstract = {Herein, we report an unconventional heterobidentate coordination mode of conventional 4-hydroxypyridine ligand in a novel compound Zn(C 5 H 4 NO) 2 . The strong heterobidentate coordination interactions between Zn 2+ and 4-hydroxypyridine ligands promote a uniform alignment of the polarization of each [ZnO 2 N 2 ] tetrahedral building unit, resulting in remarkably strong second-harmonic generation (SHG) with an intensity that is the largest among all UV-transparent Zn-containing metal-organic compounds reaching 13.6×KDP. Moreover, Zn(C 5 H 4 NO) 2 processes a suitable optical band gap of 4.40 eV, high thermal stability up to 300 °C, excellent air stability, and strong water resistance, demonstrating great application potential. Additionally, Zn(C 5 H 4 NO) 2 exhibits photoluminescence with a significantly enhanced lifetime of 558 ms, accompanied by a rare blue afterglow visible to the naked eye, lasting up to 5 s.}, archive = {J_ANGEW}, author = {Can Yang and Jie Gou and Yaolong Zhu and Yi Xiong and Zece Zhu and Ling Chen and Qi Wu}, doi = {10.1002/anie.202420810}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420810}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unconventional heterobidentate coordination of 4-hydroxypyridine leading to remarkably strong second-harmonic generation in Zn(C5H4NO)2}, volume = {64}, year = {2025}, }
• (2025). In-situ constructed core-shell catalyst enabling subzero capacity unlocking of cost-effective and long-life vanadium flow batteries. ANGEW, 64(9), e202420794. (www)

  @article{ , abstract = {Vanadium flow battery (VFB) promises a route for achieving grid-scale power storage by harnessing renewable energy sources. However, the sluggish reaction kinetics of vanadium redox couples and serious hydrogen evolution reaction (HER) still restrict the further development of VFB. Addressing these challenges requires not only effective solutions but also ones that are cost-efficient and scalable to meet the demands of affordable energy storage. Here, we present an in situ constructed Cu@Cu 6 Sn 5 core-shell catalyst by incorporating metal ions into the electrolyte. The Cu core, encapsulated by the Cu 6 Sn 5 shell, forms an excellent conductive pathway to the graphite felt electrode. Charge transfer between Cu and Sn within Cu 6 Sn 5 shell accelerates the reaction kinetics of V 2+ /V 3+ redox couple and selectively inhibits HER, as confirmed through in situ weak measurement imaging method. The Cu@Cu 6 Sn 5 battery achieves a peak power density of 1119.1 mW cm −2 at 1350 mA cm −2 , operates stably for 1200 cycles without catalyst failure, and is available over a wide-temperature range. Furthermore, we identify a demand of subzero capacity unlocking. Achieving a 23.4 % theoretical capacity unlocking at −10 °C with a cut-off voltage up to 1.75 V, bespeaking a crucial breakthrough toward cost-effective VFB.}, archive = {J_ANGEW}, author = {Yizhe Nie and Rui Nie and Hao Lin and Jiajun Wu and Lihong Yu and Le Liu and Jingyu Xi}, doi = {10.1002/anie.202420794}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420794}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-situ constructed core-shell catalyst enabling subzero capacity unlocking of cost-effective and long-life vanadium flow batteries}, volume = {64}, year = {2025}, }
• (2025). A FRET autophagy imaging platform by macrocyclic amphiphile. ANGEW, 64(9), e202420793. (www)

  @article{ , abstract = {Autophagy is a ubiquitous process of organelle interaction in eukaryotic cells, in which various organelles or proteins are recycled and operated through the autophagy pathway to ensure nutrient and energy homeostasis. Although numerous fluorescent probes have been developed to image autophagy, these environment-responsive probes suffer from inherent deficiencies such as inaccuracy and limited versatility. Here, we present a modular macrocyclic amphiphile Förster Resonance Energy Transfer (FRET) platform (SC6A12C/NCM, SN), constructed through the amphiphilic assembly of sulfonatocalix[6]arene (SC6A12C) with N -cetylmorpholine (NCM) for lysosome targeting. The hydrophobic fluorophore BPEA (FRET donor) was entrapped within the inner hydrophobic phase and showed strong fluorescence emission. Attributed to the broad-spectrum encapsulation of SC6A12C, three commercially available organelle probes (Mito-Tracker Red, ER Tracker Red, and RhoNox-1) were selected as SC6A12C guests (FRET acceptors). During autophagy process, the formation of intracellular host–guest complexes leads to strong FRET signal, allowing us to visualize the fusion of mitochondria, endoplasmic reticulum, and Golgi apparatus with lysosomes, respectively. This study provides a versatile and accessible platform for imaging organelle autophagy.}, archive = {J_ANGEW}, author = {Ze-Tao Jiang and Jie Chen and Fang-Yuan Chen and Yuan-Qiu Cheng and Shun-Yu Yao and Rong Ma and Wen-Bo Li and Hongzhong Chen and Dong-Sheng Guo}, doi = {10.1002/anie.202420793}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420793}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A FRET autophagy imaging platform by macrocyclic amphiphile}, volume = {64}, year = {2025}, }
• (2025). Photomodulated transient catalytic constitutional dynamic networks and reaction circuits. ANGEW, 64(9), e202420787. (www)

  @article{ , abstract = {A method to photomodulate dynamically transient DNA-based reaction circuits and networks is introduced. The method relies on the integration of photoresponsive o-nitrobenzyl-phosphate ester-caged DNA hairpin with a “mute” reaction module. Photodeprotection (λ=365 nm) of the hairpin structure separates a fuel strand triggering the dynamic, transient, operation of the DNA circuit/network. By temporal photocleavage of the hairpin within the course of transient operation of the circuit, photomodulation of the systems are demonstrated. The modulation amplitude and rhythms are controlled by the time-interval and cycle numbers of photo-deprotecting the hairpin structure. The method is applied to transiently photomodulate the catalytic activities of a DNAzyme, enabling the photomodulation of the transient assembly of a constitutional dynamic network (CDN) and the transient reconfiguration of the CDN framework. The different systems are supported by computational kinetic models allowing to predict, and experimentally validate, the behavior of the systems under variable auxiliary conditions. Moreover, the photomodulated transient CDNs are implemented as functional frameworks guiding the thrombin-catalyzed coagulation of fibrinogen to fibrin (fibrinogenesis) and photomodulated operation of a biocatalytic cascade.}, archive = {J_ANGEW}, author = {Yu Ouyang and Itamar Willner}, doi = {10.1002/anie.202420787}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420787}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photomodulated transient catalytic constitutional dynamic networks and reaction circuits}, volume = {64}, year = {2025}, }
• (2025). Host-guest assemblies of polyoxovanadate clusters as supramolecular catalysts. ANGEW, 64(9), e202420773. (www)

  @article{ , abstract = {Supramolecular functional materials can be used to overcome some of the most challenging tasks in materials science, where the dynamic nature of supramolecular interactions can be leveraged to fine-tune the properties of the material for a given task. The Lindqvist hexavanadate family of polyoxometalates (POMs) have emerged as particularly interesting candidates to be used in supramolecular materials due to their redox and Lewis acid properties that enable their application in the fields of energy conversion/storage or catalysis. Despite their promising potential, hexavanadate clusters are underrepresented in the field of supramolecular materials, mainly due to the synthetic challenges related to their inherent reactivity. In this work, pillar[5]arene was successfully grafted onto a Lindqvist hexavanadate and the resulting structure was confirmed by single crystal X-ray diffraction (SC-XRD), presenting the first example of a crystal structure of a POMcovalently functionalized with a pillar[5]arene. By introducing a ditopic guest molecule that could interlink pillar[5]arene moieties, host–guest interactions were leveraged as the driving force for the formation of supramolecular assemblies incorporating hexavanadate clusters in a controlled manner. The enhanced catalytic performance of the resulting aggregates confirmed their potential application as functional catalytic materials. This novel approach for developing hexavanadate-based catalysts reported here showcases the potential of using host–guest interactions as a means to introduce catalytically active metal-oxo clusters into supramolecular frameworks.}, archive = {J_ANGEW}, author = {Givi Kalandia and Cui-Lian Liu and David E. Salazar Marcano and Mhamad Aly Moussawi and Sem Bleus and Bart Van Meerbeek and Wim Dehaen and Tatjana N. Parac-Vogt}, doi = {10.1002/anie.202420773}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420773}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Host-guest assemblies of polyoxovanadate clusters as supramolecular catalysts}, volume = {64}, year = {2025}, }
• (2025). Manipulating interphase chemistry for aqueous zn stabilization: The role of supersaturation. ANGEW, 64(9), e202420772. (www)

  @article{ , abstract = {The limited cycling durability of Zn anode, attributed to the absence of a robust electrolyte-derived solid electrolyte interphase (SEI), remains the bottleneck for the practical deployment of aqueous zinc batteries. Herein, we highlight the role of local supersaturation in governing the fundamental crystallization chemistry of Zn 4 SO 4 (OH) 6 ⋅xH 2 O (ZSH) and propose a subtle supersaturation-controlled morphology strategy to tailor the interphase chemistry of Zn anode. By judiciously creating local high-supersaturation environment with organic caprolactam to manipulate the precipitation manner of zinc sulfate hydroxide (ZSH), lattice-lattice matched heterogeneous nucleation of ZSH (001) and Zn (002) is realized in aqueous ZnSO 4 , producing a dense, pseudo-coincidence interface capable of functioning as decent SEI. The plating/stripping efficacy of Zn is significantly boosted, as reflected by the great improvement of the initial (from 59.9 % to 84.1 %) and average (from 94.0 % to 99.2 %) coulombic efficiency. Accordingly, the cyclic endurance of Zn anode is prolonged from 50 h to over 7000 h at 0.5 mA cm −2 /1 mAh cm −2 , witnessing 140-fold lifespan extension. Profiting from supersaturation-mediated Zn stabilization, the performance deterioration of zinc-vanadium batteries is also alleviated, even with a low N/P ratio of 4.4. This work is anticipated to deepen current understanding on the control of the anodic chemistry.}, archive = {J_ANGEW}, author = {Qinyang Wang and Zhaoyu Zhang and Zuyang Hu and Wencheng Du and Yufei Zhang and Minghui Ye and Zhipeng Wen and Yongchao Tang and Xiaoqing Liu and Cheng Chao Li}, doi = {10.1002/anie.202420772}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating interphase chemistry for aqueous zn stabilization: The role of supersaturation}, volume = {64}, year = {2025}, }
• (2025). A hollowed-out heterometallic cluster for catalytic knoevenagel condensation. ANGEW, 64(9), e202420770. (www)

  @article{ , abstract = {Lanthanide-containing clusters are synthetically challenging and with significant chemical and materials applications. Herein, two isostructural heterometallic clusters of the formula (NO 3 ) 12 @[Ln 132 Ni 78 (OH) 292 (IDA) 48 (CH 3 COO) 96 (NO 3 ) 12 (H 2 O) 78 ]Cl 44 ⋅ x H 2 O⋅ y CH 3 OH (IDA=iminodiacetate; Ln=Gd 1 , x =110, y =0; Ln=Eu 2 , x =95, y =40) were obtained via co-hydrolysis of Ln 3+ (Gd 3+ or Eu 3+ ) and Ni 2+ in the presence of iminodiacetate (IDA). Crystallographic studies show that each features a truncated tetrahedral core of Ln 132 Ni 78 within which a void of 1.1 nm in diameter; connecting the central cage and its exterior are four trumpet-like passageways surface-decorated with dinuclear units of [Gd( μ 3 -OH) 2 Gd]. Mass spectroscopic analyses indicate that both clusters maintained their structural integrity in aqueous solution, with cryo-electron microscopy providing the most convincing visual evidence in support of the cluster‘s solution stability. Size-selective Knoevenagel condensation, believed to occur in the passageways on the basis of experimental and molecular modeling results, was achieved in the presence of 1 . The application of 1 as a uniquely structured molecular reactor and a recyclable heterogeneous catalyst was further illustrated by the one-pot three-component synthesis of biologically and pharmaceutically significant 4 H -pyran derivatives.}, archive = {J_ANGEW}, author = {Wanmin Chen and Na Xu and Lei Qin and Yi-Fei Deng and Gui-Lin Zhuang and Zhe Zhang and Ting-Zheng Xie and Pingshan Wang and Zhiping Zheng}, doi = {10.1002/anie.202420770}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420770}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A hollowed-out heterometallic cluster for catalytic knoevenagel condensation}, volume = {64}, year = {2025}, }
• (2025). Targeted synthesis of interpenetration-free mesoporous aromatic frameworks by manipulating catalysts as templates. ANGEW, 64(9), e202420746. (www)

  @article{ , abstract = {Reticular chemistry allows the design and synthesis of mesoporous networks by extending the size of the building blocks. However, interpenetration of the nets easily happens against the designed mesoporous networks, thereby falling short of achieving the intended specific surface area and pore size. Controlling the framework interpenetration has always been a challenge in the synthesis section of reticular chemistry. In this work, based on our previously reported type of highly porous aromatic frameworks (named PAF-1), we extended the tetrahedral building blocks to target an iso-reticular mesoporous PAF-333. A series of Ni(0) ligands with different sizes were employed to confirm that suitable-sized catalyst ligands could successfully inhibit skeleton interpenetration in the coupling reaction through the steric hindrance effect. The obtained mesoporous PAF-333 possessed a pore size of approximately 3.2 nm matching well with the value from the predicted non-interpenetrated structure. PAF-333 showed great high-pressure hydrogen and methane storage potential with a 13.4 wt % H 2 uptake at 77 K, 100 bar and a 0.537 g g −1 CH 4 uptake at 298 K, 98 bar, ranking at the top of the reported porous adsorbents in the gas storage applications.}, archive = {J_ANGEW}, author = {Zihao Wang and Li Jiang and Jiangtao Jia and Guangshan Zhu}, doi = {10.1002/anie.202420746}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Targeted synthesis of interpenetration-free mesoporous aromatic frameworks by manipulating catalysts as templates}, volume = {64}, year = {2025}, }
• (2025). Acid-enhanced photoiniferter polymerization under visible light. ANGEW, 64(9), e202420733. (www)

  @article{ , abstract = {Photoiniferter (PI) is a promising polymerization methodology, often used to overcome restrictions posed by thermal reversible addition-fragmentation chain-transfer (RAFT) polymerization. However, in the overwhelming majority of reports, high energy UV irradiation is required to effectively trigger photolysis of RAFT agents and facilitate the polymerization, significantly limiting its potential, scope, and applicability. Although visible light PI has emerged as a highly attractive alternative, most current approaches are limited to the synthesis of lower molecular weight polymers (i.e. 10,000 g/mol), and typically suffer from prolonged reaction times, extended induction periods, and higher dispersities when high activity CTAs (photoiniferters), such as trithiocarbonates, are employed. Herein, an acid-enhanced PI polymerization is introduced that efficiently operates under visible light irradiation. The presence of small amounts of biocompatible citric acid fully eliminates the lengthy induction period (21 hours) by enhancing photolysis, rapidly consuming the CTA, and accelerating the reaction rate, yielding polymers with narrow molar mass distributions ( Ð ~1.1), near-quantitative conversions (>97 %), and high end-group fidelity in just two hours. A particularly noteworthy aspect of this work is the possibility to target very high degrees of polymerization (i.e. DP=3,000) within short timescales (i.e. less than five hours) without compromising the control over the dispersity ( Ð ~1.1). The versatility of the technique is further demonstrated through the synthesis of well-defined diblock copolymers and its compatibility to various polymer classes (i.e. acrylamides, acrylates, methacrylates), thus establishing visible-light PI as a robust tool for polymer synthesis.}, archive = {J_ANGEW}, author = {Maria-Nefeli Antonopoulou and Nghia P. Truong and Timon Egger and Asja A. Kroeger and Michelle L. Coote and Athina Anastasaki}, doi = {10.1002/anie.202420733}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420733}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Acid-enhanced photoiniferter polymerization under visible light}, volume = {64}, year = {2025}, }
• (2025). Evolution of supramolecular coordination assemblies visually monitored by time-dependent multicolor fluorescence. ANGEW, 64(9), e202420707. (www)

  @article{ , abstract = {Supramolecular coordination assemblies play an important role in both material science and biological systems. Despite significant efforts in their development, most existing examples are thermodynamically controlled, which lack the adaptability and autonomy essential for the creation of advanced materials. In this work, we have developed non-equilibrium coordination assembly systems that can evolve over time through a combination of thermodynamic and kinetic controls. The introduction of zinc ions resulted in the formation of metastable fiber assemblies in a kinetically trapped state, which autonomously converted to thermodynamically stable nanosheets over time. This evolution process can be regulated by external stimuli and visually monitored by the time-dependent multicolor fluorescence. The construction strategy was versatile across other various ions such as Ca 2+ , Mg 2+ , and Al 3+ , offering inspiring insights for the design of complex systems that operated both in and out of their thermodynamic equilibrium.}, archive = {J_ANGEW}, author = {Hanren Xu and Qian Wang and Zhen Qi and Xianghao Li and Yifan Lei and Hongyu An and He Tian and Da-Hui Qu}, doi = {10.1002/anie.202420707}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evolution of supramolecular coordination assemblies visually monitored by time-dependent multicolor fluorescence}, volume = {64}, year = {2025}, }
• (2025). Regulating crystalline Phase/Plane of polymer electrolyte for rapid lithium ion transfer. ANGEW, 64(9), e202420698. (www)

  @article{ , abstract = {Electronic-rich functional groups and flexible segments have long been perceived to be the decisive factors influencing lithium-ion transfer in polymer electrolytes, while crystallinity is regarded as the great scourge. Actually, the research on the influence of crystalline phase and crystalline plane is still in scarcity. Herein, taking poly(vinylidene fluoride)-hexafluoropropylene (PVDF-HFP) as an example, new (111/201) crystal planes (belonged to β-phase) are regulated by dissolving process and clarified by Synchrotron radiation X-ray diffraction and X-ray diffraction. Density functional theory calculation indicates that the newly exposed (111/201) crystal planes provide higher binding energy with lithium ions and are conducive to provide more ion transport channels. 7 Li nuclear magnetic resonance of new crystalline planes contained PVDF-HFP based electrolyte shows lower field and sharper peak intensity, further proves the rapid lithium ion transfer. Therefore, a high ionic conductivity of 6.42×10 −4 S cm −1 and a large lithium-ion transfer number of 0.7 are achieved. This study offers a new insight into the influence of crystalline phase and crystalline plane on the transfer of lithium ion for polymer electrolytes.}, archive = {J_ANGEW}, author = {Su Wang and Chen Li and Yue Ma and Hongzhou Zhang and Xixi Shi and Lianqi Zhang and Dawei Song}, doi = {10.1002/anie.202420698}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating crystalline Phase/Plane of polymer electrolyte for rapid lithium ion transfer}, volume = {64}, year = {2025}, }
• (2025). Solvent-free chemical recycling of polyesters and polycarbonates by magnesium-based lewis acid catalyst. ANGEW, 64(9), e202420688. (www)

  @article{ , abstract = {Developing a simple and efficient catalyst system for closed-loop recycling of polymers to monomers is an essentially important but challenging task for the recycle of polymer wastes and preventing the downcycle of plastic products. Herein, we employ inexpensive, commercially available Lewis acids (LAs) to achieve closed-loop recycling in bulk through the catalytic depolymerization of aliphatic polyesters and polycarbonates. The scope of LAs is screened by thermogravimetric analysis experiments and distillation experiments. MgCl 2 shows the best catalytic performance that can efficiently depolymerize eleven aliphatic polyesters and polycarbonates (i.e. poly( ϵ -caprolactone) and poly(trimethylene carbonate)), into monomers (up to 98 % yield) at temperatures significantly lower than the ceiling temperature. Moreover, this catalyst system exhibits high selectivity and compatibility towards the depolymerization of (co)polyesters as well as the blends of polyesters and polycarbonates in the presence of other commodity plastics, as well as excellent recycle and reuse catalyst performance. Mechanistic studies indicate that the closed-loop recycling of monomers is achieved through the random chain scission and terminal group cyclization.}, archive = {J_ANGEW}, author = {Wuchao Zhao and Zongpeng Guo and Jianghua He and Yuetao Zhang}, doi = {10.1002/anie.202420688}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420688}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-free chemical recycling of polyesters and polycarbonates by magnesium-based lewis acid catalyst}, volume = {64}, year = {2025}, }
• (2025). Achieving over 20 % efficiency in laminated HTM-free carbon electrode perovskite solar cells through in situ interface reconstruction. ANGEW, 64(9), e202420687. (www)

  @article{ , abstract = {Laminating a free-standing carbon electrode film onto perovskite film is a promising method for fabricating HTM (hole transport material)-free carbon electrode perovskite solar cells (c-PSCs), offering more flexibility by decoupling the processes of carbon electrode and perovskite layer formation. However, the power conversion efficiency (PCE) of laminated HTM-free c-PSCs (<16.5 %) remains lower compared to c-PSCs with printed carbon pastes (>20 %), primarily due to poor interfacial contact between the perovskite and carbon layers. Herein, we report a chemical-mechanical driven in situ interface reconstruction strategy to solve such interface contact issues. The in situ interface reconstruction is firstly triggered by methylammonium chloride (MACl) surface treatment to chemically activate the film and then mechanically laminate the carbon electrode onto the softened perovskite film under heating. The perovskite film undergoes in situ regrowth and the carbon film starts to cure simultaneously, dynamically reconstructing the perovskite/carbon electrode interface. A tighter and conformal contact is achieved, greatly facilitating the carrier transport and extract. Ultimately, a champion PCE of 20.31 % is achieved with enhanced stability. Our in situ interface reconstruction strategy which is combinating the chemical and mechanical process offers a new choice for the further design of low-cost and efficient HTM-free c-PSCs.}, archive = {J_ANGEW}, author = {Guopeng Huang and Taiyang Zhang and Weidong Lin and Lixia Qin and Shi-Zhao Kang and Xiangqing Li}, doi = {10.1002/anie.202420687}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420687}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving over 20 % efficiency in laminated HTM-free carbon electrode perovskite solar cells through in situ interface reconstruction}, volume = {64}, year = {2025}, }
• (2025). Unlocking mesoscopic disorder in graphitic carbon with spectroelectrochemistry. ANGEW, 64(9), e202420680. (www)

  @article{ , abstract = {Intrinsic structural and oxidic defects activate graphitic carbon electrodes towards electrochemical reactions underpinning energy conversion and storage technologies. Yet, these defects can also disrupt the long-range and periodic arrangement of carbon atoms, thus, the characterization of graphitic carbon electrodes necessitates in-situ atomistic differentiation of graphitic regions from mesoscopic bulk disorder. Here, we leverage the combined techniques of in-situ attenuated total reflectance infrared spectroscopy and first-principles calculations to reveal that graphitic carbon electrodes exhibit electric-field dependent infrared activity that is sensitive to the bulk mesoscopic intrinsic disorder. With this platform, we identify graphitic regions from amorphous domains by discovering that they demonstrate opposing electric-field-dependent infrared activity under electrochemical conditions. Our work provides a roadmap for identifying mesoscopic disorder in bulk carbon materials under potential bias.}, archive = {J_ANGEW}, author = {Ry Papadopoulos and Benjamin Masters and Arpan Kundu and Nicholas Maldonado and Alexander S. Filatov and Yuzi Liu and Taemin Kim and Giulia Galli and Anna Wuttig}, doi = {10.1002/anie.202420680}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking mesoscopic disorder in graphitic carbon with spectroelectrochemistry}, volume = {64}, year = {2025}, }
• (2025). The role of electron transfer in copper-mediated C(sp2)−H trifluoromethylation. ANGEW, 64(9), e202420677. (www)

  @article{ , abstract = {We report copper(II) and copper(III) trifluoromethyl complexes supported by a pyridinedicarboxamide ligand ( L ) as a platform for investigating the role of electron transfer in C(sp 2 )−H trifluoromethylation. While the copper(II) trifluoromethyl complex is unreactive towards (hetero)arenes, the formal copper(III) trifluoromethyl complex performs C(sp 2 )−H trifluoromethylation of a wide range of (hetero)arenes. Mechanistic studies using the copper(III) trifluoromethyl complex suggest that the mechanism of arene trifluoromethylation is substrate-dependent. When the thermodynamic driving force for electron transfer is high, the reaction proceeds through a previously unidentified single electron transfer (SET) mechanism, where an initial electron transfer occurs between the substrate and oxidant prior to CF 3 group transfer. Otherwise, a CF 3 radical release/electrophilic aromatic substitution (S E Ar) mechanism is followed. These studies provide valuable insights into the role of strong oxidants and potential mechanistic dichotomy in Cu-mediated C(sp 2 )−H trifluoromethylation.}, archive = {J_ANGEW}, author = {Margaret A. P. Ball and Preston J. Myers and Grayson D. Ritch and Jamey K. Bower and Curtis E. Moore and Nathaniel K. Szymczak and Shiyu Zhang}, doi = {10.1002/anie.202420677}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420677}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The role of electron transfer in copper-mediated C(sp2)−H trifluoromethylation}, volume = {64}, year = {2025}, }
• (2025). Visible-light photocatalyzed skeletal rearrangement enables the synthesis of highly functionalized xanthenes with antitumor activity. ANGEW, 64(9), e202420671. (www)

  @article{ , abstract = {Highly functionalized xanthenes possess an impressive range of bioactivities and daunting synthetic challenge due to their unique ring systems and stereocenters. Here, we report an unprecedented ketyl radicals-induced skeletal rearrangement reaction of spirodihydrobenzofurans, enabled by zero-valent iron as reducing agents via photoredox catalysis, facilitating the facile preparation of various highly functionalized xanthenes. The features of this protocol include high chemo- and regioselectivity, exceptionally mild conditions, a broad substrate scope, scalability to gram-scale quantities, and consistent delivery of good to excellent yields. Mechanistic studies rationalize the function of this zero-valent iron-based reactivity in radical generation. Notably, this reaction was applied to the first asymmetric total synthesis of the complex polycyclic xanthene ent -myrtucomvalones E−F. Moreover, this work led to the discovery of an agent with highly effective antiosteosarcoma activity in vitro and in vivo, potentially paving the way for the development of new xanthene-based candidates for osteosarcoma treatment.}, archive = {J_ANGEW}, author = {Shi-Lin Lin and Fen Zhao and Fen Wei and Ying-Tong Shi and Jing-Kai Wen and Chao Yang and Hao-Shuo Zhang and Chuang-Chuang Li and Chang Liu and Wen-Cai Ye and Min-Jing Cheng and Lei Wang}, doi = {10.1002/anie.202420671}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420671}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-light photocatalyzed skeletal rearrangement enables the synthesis of highly functionalized xanthenes with antitumor activity}, volume = {64}, year = {2025}, }
• (2025). Strained dehydro-[2,2]-paracyclophane enabled planar chirality construction and [2.2]Paracyclophane functionalization. ANGEW, 64(9), e202420667. (www)

  @article{ , abstract = {Planar chirality found tremendous use in many fields, such as chemistry, optics, and materials science. In particular, planar chiral [2.2]paracyclophanes (PCPs) are a type of structurally interesting and practically useful chiral compounds bearing unique electronic and photophysical properties and thus have been widely used in π-stacking polymers, organic luminescent materials, and as a valuable toolbox for developing chiral ligands or organocatalysts. However, the synthesis of chiral PCP derivatives remains a longstanding challenge. Current synthetic methods primarily rely on chiral preparative liquid chromatography separation or chemical and kinetic resolution reactions. Here, we report an enantioconvergent alkynylation of an in situ -formed dehydro-[2,2]-paracyclophane intermediate by asymmetric copper(I) catalysis. This approach enables the efficient synthesis of valuable planar chiral PCP building blocks and heterocycles with good yields and excellent enantioselectivity. The success of this reaction lies in the development of a practical route to access strained dehydro-[2,2]-paracyclophane intermediates, which can also be utilized in various strain-release nucleophilic or cycloaddition reactions to synthesize diverse functionalized PCPs. DFT calculations of this reaction suggest that the enantioselectivity is determined by the aryne complexation with chiral copper(I) acetylide and the subsequent insertion reaction.}, archive = {J_ANGEW}, author = {Xue Zhang and Yi Zhou and Zhi-Xiang Yu and Chen-Ho Tung and Zhenghu Xu}, doi = {10.1002/anie.202420667}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420667}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strained dehydro-[2,2]-paracyclophane enabled planar chirality construction and [2.2]Paracyclophane functionalization}, volume = {64}, year = {2025}, }
• (2025). Enhancing CO2 electroreduction to multicarbon products by modulating the surface microenvironment of electrode with polyethylene glycol. ANGEW, 64(9), e202420661. (www)

  @article{ , abstract = {Modulating the surface microenvironment of electrodes stands as a pivotal aspect in enhancing the electrocatalytic performance for CO 2 electroreduction. Herein, we propose an innovative approach by incorporating a small amount of linear oligomer, polyethylene glycol (PEG), into Cu 2 O catalysts during the preparation of the Cu PEG electrode. The Faradaic efficiency (FE) toward multicarbon products (C 2+ ) increases from 69.3 % over Cu electrode without PEG to 90.3 % over Cu PEG electrode at 500 mA cm −2 in 1 M KOH in a flow cell. In situ investigations and theoretical calculations reveal that PEG molecules significantly modify the microenvironment on the Cu surface through hydrogen bond interactions. This modification leads to the relaxation of Nafion, increasing the availability of active sites and enhancing the adsorption of *CO and *OH, which in turn promotes C−C coupling. Concurrently, the reconstructed hydrogen bond network reduces the presence of active hydrogen species, thereby inhibiting the hydrogen evolution reaction.}, archive = {J_ANGEW}, author = {Yiyong Wang and Yingying Cheng and Shiqiang Liu and Yaoyu Yin and Jiahao Yang and Hengan Wang and Ke Li and Meng Zhou and Jiapeng Jiao and Pei Zhang and Qingli Qian and Qinggong Zhu and Xiaofu Sun and Yi Xu and Mingchuan Luo and Xinchen Kang and Buxing Han}, doi = {10.1002/anie.202420661}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing CO2 electroreduction to multicarbon products by modulating the surface microenvironment of electrode with polyethylene glycol}, volume = {64}, year = {2025}, }
• (2025). Efficient energy transfer from quantum dots to closely-bound dye molecules without spectral overlap. ANGEW, 64(9), e202420658. (www)

  @article{ , abstract = {Quantum dots (QDs) are semiconductor nanocrystals whose optical properties can be tuned by altering their size. By combining QDs with dyes we can make hybrid QD-dye systems exhibiting energy transfer (ET) between QDs and dyes, which is important in sensing and lighting applications. In conventional QDs that need a shell to passivate surface defects, ET usually proceeds through Förster resonance energy transfer (FRET) that requires significant spectral overlap between QD emission and dye absorbance, as well as large oscillator strengths of those transitions. This considerably limits the choice of dyes. In contrast, perovskite QDs do not require passivating shells for bright emission, which makes ET mechanisms beyond FRET accessible. This work explores the design of a CsPbBr 3 QD-dye system to achieve efficient ET from CsPbBr 3 QDs to dyes with dimethyl iminium binding groups where the close binding of dyes to CsPbBr 3 surface facilitates spatial wavefunction overlap. Using steady-state and time-resolved photoluminescence experiments, we demonstrate that efficient ET from CsPbBr 3 to dyes with minimal spectral overlap proceeds via the Dexter exchange-type mechanism, which overcomes the conventional restriction of spectral overlap that severely limits the tunability of these systems. This approach opens new avenues for QD-molecule hybrids for a wide range of applications, such as lighting.}, archive = {J_ANGEW}, author = {Mariam Kurashvili and Jordi Llusar and Lena S. Stickel and Tim Würthner and David Ederle and Ivan Infante and Jochen Feldmann and Quinten A. Akkerman}, doi = {10.1002/anie.202420658}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient energy transfer from quantum dots to closely-bound dye molecules without spectral overlap}, volume = {64}, year = {2025}, }
• (2025). Tailoring the reprocessability of thiol-ene networks through ring size effects. ANGEW, 64(9), e202420657. (www)

  @article{ , abstract = {Recycling thermosetting materials presents itself as a major challenge in achieving sustainable material use. Dynamic covalent cross-linking of polymers has emerged as a viable solution that can combine the structural integrity of thermosetting materials with the (re−)processability of thermoplastics. Thioether linkages between polymer chains are quite common, and their use dates back to the vulcanization of rubbers. While it is known that thioether bonds can be triggered to exchange through transalkylation reactions, this process is usually slow, as thioether moieties not only have to be activated by an alkylating agent, but the activated thioether also has to associate with a second thioether moiety in a classical S N 2-type process. Here, we present the rational design of dynamic polymer networks based on simple dithiol-based monomers and a fatty acid derived triene. Two neighboring thioethers can undergo a much faster bond exchange reaction, and we found that the exchange dynamics can be further tuned over almost three orders of magnitude by tailoring the distance between two thioether functionalities. This resulted in thioether-cross-linked materials that could be processed by extrusion, a continuous reprocessing technique that was previously not accessible for this class of cross-linked materials, while still exhibiting appealing creep-resistance below 70 °C.}, archive = {J_ANGEW}, author = {Vincent Scholiers and Susanne M. Fischer and Bram Daelman and Sandro Lehner and Sabyasachi Gaan and Johan M. Winne and Filip E. Du Prez}, doi = {10.1002/anie.202420657}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420657}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring the reprocessability of thiol-ene networks through ring size effects}, volume = {64}, year = {2025}, }
• (2025). Electron transfer mediator modulates type II porphyrin-based Metal–Organic framework photosensitizers for type i photodynamic therapy. ANGEW, 64(9), e202420643. (www)

  @article{ , abstract = {Photodynamic therapy (PDT), a minimally invasive and effective local treatment, heavily depends on photosensitizer (PS) performance and oxygen availability. Despite the use of PS-based metal–organic frameworks (MOFs) to address the solubility and aggregation issues of PSs, the inherent hypoxic intolerance of mainstream Type II PDT remains challenging. Herein, we report an electron transfer strategy for the fabrication of hypoxia-tolerant Type I MOFs by encapsulating thymoquinone (TQ) into existing Type II MOFs. With TQ serving as an effective electron transfer mediator, it facilitates the electron transfer process from the MOF ligand PS to oxygen, establishing the Type I pathway and attenuating the original Type II pathway. Four representative porphyrin-based MOFs are synthesized to demonstrate the proposed strategy. Our findings reveal that TQ@MOF-1 nanoparticles (NPs) exhibit enhanced anticancer activity under hypoxic conditions and superior in vivo antitumor efficacy compared to parent MOF-1 NPs. This work offers an effective and universal strategy to modulate ROS generation in PS-based MOFs, endowing hypoxic tolerance with improved PDT performance against solid tumors.}, archive = {J_ANGEW}, author = {Jiahao Zhuang and Shitai Liu and Bowen Li and Zhiyao Li and Chongzhi Wu and Duo Xu and Weidong Pan and Zhen Li and Xiaogang Liu and Bin Liu}, doi = {10.1002/anie.202420643}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420643}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electron transfer mediator modulates type II porphyrin-based Metal–Organic framework photosensitizers for type i photodynamic therapy}, volume = {64}, year = {2025}, }
• (2025). Low-temperature CO2 hydrogenation to olefins on anorthic NaCoFe alloy carbides. ANGEW, 64(9), e202420621. (www)

  @article{ , abstract = {The hydrogenation of carbon dioxide to olefins (CTO) represents an ideal pathway towards carbon neutrality. However, most current CTO catalysts require a high-temperature condition of 300–450 °C, resulting in high energy consumption and possible aggregation among active sites. Herein, we developed an efficient iron-based catalyst modified with high-sodium content (7 %) and low-cobalt content (2 %), achieving a CO 2 conversion of 22.0 % and an olefin selectivity of 55.9 % at 240 °C and 1000 mL/g/h, and it is even active at 180 °C and 4000 mL/g/h with more than 25 % olefins in hydrocarbons. The catalyst was kept stable under continuous operating conditions of 500 hours. Numerous characterizations and calculations reveal high content of sodium as an electronic promoter enhances the stability of the active anorthic Fe 5 C 2 phase at low temperatures. Further incorporating the above catalyst with cobalt, as a structural promoter, causes Fe species to form a Fe x Co y alloying phase, which in turn facilitates the formation of higher active anorthic (Fe x Co y ) 5 C 2 phase, different from the conventional carbides and alloy carbides. An in-depth investigation of the synergistic effects of structural and electronic promoters can improve catalyst performance, increase reaction efficiency and cost-effectiveness, and provide profound insights for understanding and optimizing CO 2 hydrogenation reactions.}, archive = {J_ANGEW}, author = {Jianxiang Han and Yu Han and Jiafeng Yu and Yannan Sun and Xiwen Cui and Qingjie Ge and Jian Sun}, doi = {10.1002/anie.202420621}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420621}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-temperature CO2 hydrogenation to olefins on anorthic NaCoFe alloy carbides}, volume = {64}, year = {2025}, }
• (2025). Low evaporation enthalpy ionic covalent organic frameworks for efficient atmospheric water harvesting at low humidity. ANGEW, 64(9), e202420619. (www)

  @article{ , abstract = {Herein, we introduce a series of ionic covalent organic frameworks (iCOFs) with a focus on addressing the challenge of water collection at low relative humidity levels below 25 %. These iCOFs are characterized by numerous hydrophilic sites and high water stability, enabling efficient water vapor adsorption even at relatively low humidity levels. Through the use of various hygroscopic salt cations and precise control of ion concentration within the pores, the water state within the iCOFs pores can be effectively managed. Among the iCOFs, TB-COF-Li stands out with an impressive adsorption capacity of 0.24 g g −1 from 0 to 22 % RH. Notably, due to its ionic porous structure, TB-COF-Li exhibits a significantly lower enthalpy of evaporation, measured at 967.04 J g −1 , compared to bulk water with an enthalpy of 2387.40 J g −1 . Moreover, under simulated conditions of 1.5 solar intensity at 60 °C, the majority of the adsorbed water can be rapidly desorbed without the need for additional energy input. This efficient desorption process contributes to a high water collection rate of 0.092 g g −1 h −1 in the final atmospheric water harvesting device. The development of these iCOFs offers a promising and cost-effective solution for obtaining fresh water in arid regions.}, archive = {J_ANGEW}, author = {Zheng Shi and Yu Guo and Xiuyang Zou and Jiamin Zhang and Zhiwei Chen and Mingqing Shan and Zhixin Zhang and Siyu Guo and Feng Yan}, doi = {10.1002/anie.202420619}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420619}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low evaporation enthalpy ionic covalent organic frameworks for efficient atmospheric water harvesting at low humidity}, volume = {64}, year = {2025}, }
• (2025). Ru0.1Mn0.9Ox electrocatalyst for durable oxygen evolution in acid seawater. ANGEW, 64(9), e202420615. (www)

  @article{ , abstract = {Currently, direct electrolysis of seawater for green hydrogen production is primarily focused on neutral and alkaline systems. However, the precipitation of calcium and magnesium ions restricts the advancement of this technology. An acidic system can effectively address this issue. Given that Ru/Ir-based catalysts with high oxygen evolution reaction (OER) activity also exhibit high chlorine evolution reaction (CER) activity, acid seawater splitting requires anodes with higher selectivity and stability compared to the other two systems. In this study, we propose a non-precious Ru 0.1 Mn 0.9 O x as the active anode for direct acid seawater electrolysis, which exhibits a high OER selectivity and remarkable stability for more than 1200 hours. Different from the Cl − -free system, *Cl occupied on Ru sites could shift the OER active center to Mn on Ru 0.1 Mn 0.9 O x , which prevents the lattice oxygen consumed on Ru and hinders the metal site dissolution. As the CER-insensitive catalytic center, Mn activated by the introduction of Ru can adsorb a substantial amount of *OH, creating an OER-favored local environment that inhibits CER. We introduce Cl − -assisted transfer of OER active sites to CER-insensitive Mn as a fundamental strategy for achieving highly selective and durable oxygen evolution in acidic seawater.}, archive = {J_ANGEW}, author = {Jun Xu and Chun-Chuan Kao and Haifeng Shen and Hao Liu and Yao Zheng and Shi-Zhang Qiao}, doi = {10.1002/anie.202420615}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420615}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ru0.1Mn0.9Ox electrocatalyst for durable oxygen evolution in acid seawater}, volume = {64}, year = {2025}, }
• (2025). Buffered hydroxyl radical for photocatalytic non-oxidative methane coupling. ANGEW, 64(9), e202420606. (www)

  @article{ , abstract = {Hydroxy radical (⋅OH) is a prestigious oxidant that allows the cleavage of strong chemical bonds of methane but is untamed, leading to over-oxidation of methane and waste of oxidants, especially at high methane conversion. Here, we managed to buffer ⋅OH in an aqueous solution of photo-irradiated Fe 3+ , where ⋅OH almost participates in methane oxidation. Due to the interaction between Fe 3+ and SO 4 2− , the electron transfer from OH − to excited-state Fe 3+ for ⋅OH generation is retarded, while excessive ⋅OH is consumed by generated Fe 2+ to restore Fe 3+ . When combined with a Ru/SrTiO 3 :Rh photocatalyst, the buffered ⋅OH converts methane to C 2+ hydrocarbons and H 2 with formation rates of 246 and 418 μmol h −1 , respectively. The apparent quantum efficiency reaches 13.0±0.2 %, along with 10.2 % methane conversion and 81 % C 2+ selectivity after 80 hours of reaction. Overall, this work presents a strategy for controlling active radicals for selective and efficient photocatalysis.}, archive = {J_ANGEW}, author = {Xueyuan Wang and Xueshang Xin and Lunqiao Xiong and Jianlong Yang and Tieou Wang and Yang Yang and Zhipeng Huang and Nengchao Luo and Junwang Tang and Feng Wang}, doi = {10.1002/anie.202420606}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420606}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Buffered hydroxyl radical for photocatalytic non-oxidative methane coupling}, volume = {64}, year = {2025}, }
• (2025). Locking up G-quadruplexes with light-triggered staples leads to increased topological, thermodynamic, and metabolic stability. ANGEW, 64(9), e202420592. (www)

  @article{ , abstract = {G-quadruplexes (G4 s) are secondary, tetraplexed DNA structures abundant in non-coding regions of the genome, implicated in gene transcription processes and currently firmly recognised as important potential therapeutic targets. Given their affinity for human proteins, G4 structures are investigated as potential decoys and aptamers. However, G4 s tend to adopt different conformations depending on the exact environmental conditions, and often only one displays the specifically desired biological activity. Their less intensively studied counterparts, the elusive tetraplexed intercalated-motifs (IMs) are typically unstable at neutral pH, hampering the investigation of their potential involvement in a biological context. We herein report on a photochemical method for “stapling” such tetraplexed-structures, to increase their stability, lock their topology and enhance their enzymatic resistance, while maintaining biological activity. The chemical structure and topology of the stapled Thrombin Binding Aptamer (TBA) was spectroscopically characterised and rationalised in silico. The method was then extended to other biologically relevant G4- and IM-prone sequences, hinting towards potential application of such stapled structures in a therapeutic context.}, archive = {J_ANGEW}, author = {Jack Barr and Enrico Cadoni and Sofie Schellinck and Emiliano Laudadio and José C. Martins and Annemieke Madder}, doi = {10.1002/anie.202420592}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420592}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Locking up G-quadruplexes with light-triggered staples leads to increased topological, thermodynamic, and metabolic stability}, volume = {64}, year = {2025}, }
• (2025). Deciphering the impact of aromatic linkers in self-assembled monolayers on the performance of monolithic Perovskite/Si tandem photovoltaic. ANGEW, 64(9), e202420585. (www)

  @article{ , abstract = {Aromatic linker-constructed self-assembled monolayers (Ar-SAMs) with enlarged dipole moment can modulate the work function of indium tin oxide (ITO), thereby improving hole extraction/transport efficiency. However, the specific role of the aromatic linkers between the polycyclic head and the anchoring groups of SAMs in determining the performance of perovskite solar cells (PSCs) remains unclear. In this study, we developed a series of phenothiazine-based Ar-SAMs to investigate how different aromatic linkers could affect molecular stacking, the regulation of substrate work function, and charge carrier dynamics. When served as hole-selective layers (HSLs) in PSCs and monolithic perovskite/silicon tandem solar cells (P/S-TSCs), we found that the Ar-SAM with naphthalene linker along the 2,6-position axis ( β -Nap) could form dense and highly ordered HSLs, enhancing interfacial interactions and favoring optimal energy level alignment with the perovskite films. Using this strategy, the optimized wide-band gap PSCs achieved an impressive power conversion efficiency (PCE) of 21.86 % with negligible hysteresis, utilizing a 1.68 eV perovskite. Additionally, the encapsulated devices demonstrated enhanced stability under damp-heat conditions (ISOS-D-2, 50 % RH, 65 °C) with a T 91 of 1000 hours. Notably, the fabricated P/S-TSCs, based on solution-processed micron-scale textured silicon heterojunction (SHJ) solar cells, achieved an efficiency of 28.89 % while maintaining outstanding reproducibility. This strategy holds significant promise for developing aromatic linking groups to enhance the hole selectivity of SAMs.}, archive = {J_ANGEW}, author = {Chi Li and Yong Chen and Yuheng Li and Lijie Gong and Zhen Yuan and Lusheng Liang and Jinglin Chen and Paramaguru Ganesan and Yixian Zhang and Jing Ma and Peng Gao}, doi = {10.1002/anie.202420585}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420585}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering the impact of aromatic linkers in self-assembled monolayers on the performance of monolithic Perovskite/Si tandem photovoltaic}, volume = {64}, year = {2025}, }
• (2025). Dendritic molecular baskets for selective binding of toxic methotrexate. ANGEW, 64(9), e202420574. (www)

  @article{ , abstract = {We describe the preparation, assembly, recognition characteristics, and bioactivity of dendritic basket 6 12− . This novel cavitand has a deep aromatic pocket with three ( S )-glutamic acid dendrons at the rim to amplify water solubility and prevent self-association. 1 H NMR spectroscopy, calorimetry (ITC), and mass spectrometry (ESI-MS) measurements validate the formation of an inclusion complex between 6 12− and anticancer drug methotrexate (MTX 2− ) in water ( K d =9.2 μM). To identify the docking pose, a comparison of computed (DFT and MM) and experimental 1 H NMR chemical shifts suggests that MTX 2− folds inside 6 12− (π⋅⋅⋅π), forming HBs with the peptidic dendrons while anchoring (C−H⋅⋅⋅π) to the aromatic pocket through its N-methyl group. In consequence, 6 12− selectively binds MTX 2− in competition with structurally similar folic acid and leucovorin (reversal poisoning agent). While the host is biocompatible (HEK293; IC 50 >150 μM) and produces inclusion complex [MTX⊂ 6 ] 14− in cell media, it experiences limitation in pharmacokinetic sequestration of MTX 2− as dihydrofolate reductase's affinity to the drug is suggested to prevail over that of 6 12− . Nonetheless, considering the basket's biocompatibility, tunability, and chemoselectivity, it stands as the leading candidate in the pursuit of an effective abiotic antidote for methotrexate poisoning.}, archive = {J_ANGEW}, author = {Nitesh Kumar and Tyler J. Finnegan and Sagarika Taneja and Darian C. Rostam and Alexandar L. Hansen and Carson E. Ward and Sefa Uçar and Jon R. Parquette and Jovica D. Badjić}, doi = {10.1002/anie.202420574}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420574}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dendritic molecular baskets for selective binding of toxic methotrexate}, volume = {64}, year = {2025}, }
• (2025). Coordinative self-assembly of π-electron magnetic porphyrins. ANGEW, 64(9), e202420572. (www)

  @article{ , abstract = {π-Electron magnetic compounds on surfaces have emerged as a powerful platform to interrogate spin interactions at the atomic scale, with great potential in spintronics and quantum technologies. A key challenge is organizing these compounds over large length scales, while elucidating their resulting magnetic properties. Herein, we offer a relevant contribution toward this objective, which consists of using on-surface synthesis coupled with coordination chemistry to promote the self-assembly of π-electron magnetic porphyrin species. A porphyrin precursor equipped with carbonitrile moieties in a trans arrangement was prepared by solution synthesis and deposited on Au(111)/mica. Depending on the specific growth protocol, surface-promoted reactions led to the transformation of the precursor into non-magnetic Au-CN coordinated porphyrin monomers, covalent porphyrin dimers, and one-dimensional porphyrin polymers (based on porphyrin monomers or covalent porphyrin dimers), as revealed by scanning probe microscopy studies combined with theoretical calculations. Interestingly, the scanning tunneling microscopy tip could convert such closed-shell porphyrin units into open-shell species by the removal of some peripheral hydrogen atoms. The magnetic features (i.e., singlet or triplet ground state) of the porphyrin units comprising the polymers were investigated for polymers of different lengths. No magnetic exchange coupling between adjacent units was observed, suggesting protection of the magnetic entities.}, archive = {J_ANGEW}, author = {María Tenorio and Marco Lozano and Lenka Cerna and Miguel Martínez García and Maxence Urbani and Koen Lauwaet and Kalyan Biswas and Diego Soler-Polo and Shanmugasibi K. Mathialagan and Sofía O. Parreiras and José M. Gallego and Rodolfo Miranda and José Ignacio Urgel and Tomás Torres and Pavel Jelínek and Giovanni Bottari and David Écija}, doi = {10.1002/anie.202420572}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coordinative self-assembly of π-electron magnetic porphyrins}, volume = {64}, year = {2025}, }
• (2025). The intrinsic fluorescence of peptide self-assemblies across pH levels. ANGEW, 64(9), e202420567. (www)

  @article{ , abstract = {The regulation of solution pH on the structural and optical properties of peptide self-assemblies remains a critical yet unresolved issue in peptide research. This study investigates the heptapeptide Ac-IHIHIQI-NH 2 and its intrinsic fluorescence across a range of pH levels, demonstrating that variations in pH lead to significant changes in the morphology of the self-assembled structures. While the position of the fluorescence emission remains constant—due to the stability provided by the hydrogen bonding network of the peptide backbone—the intensity of the fluorescence exhibits a direct correlation with the degree of self-assembly. This finding underscores a dynamic relationship between structural morphology and optical properties. Notably, the ability of the peptide to self-assemble under diverse pH conditions is a novel observation that contrasts with previously reported literature. By employing a computationally driven approach, complemented by rigorous experimental validation, this work establishes a new paradigm for studying complex interacting systems such as peptide self-assembly. Our findings enhance the understanding of how environmental factors influence peptide behavior and pave the way for the design of innovative peptide-based materials with tunable optical characteristics, with potential applications in bioluminescent probes and diagnostic tools for neurodegenerative diseases.}, archive = {J_ANGEW}, author = {Xiaoyu Wang and Yuqing Yang and Haokun Yang and Hao Dong}, doi = {10.1002/anie.202420567}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420567}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The intrinsic fluorescence of peptide self-assemblies across pH levels}, volume = {64}, year = {2025}, }
• (2025). Adamantane-type nitridophosphate phosphors AExLi10−2xP4N10: Eu2+ via medium-pressure ion-exchange reactions. ANGEW, 64(9), e202420565. (www)

  @article{ , abstract = {Nitridophosphates have emerged as promising host compounds in the field of solid-state lighting. Their industrial relevance has increased significantly, mainly due to recent advances in synthetic approaches under medium-pressure (MP) conditions, including ammonothermal synthesis and hot isostatic pressing (HIP). In this study, we report on the synthesis and characterization of the quaternary representatives Ca x Li 10−2 x P 4 N 10 ( x =2, 2.7, 4) and Sr 3 Li 4 P 4 N 10 , prepared via a simplified ion exchange reaction under MP conditions, starting from the nitridophosphate-based lithium ion conductor Li 10 P 4 N 10 . The synthesis route allowed for the preservation of the anionic [P 4 N 10 ] 10− structural motif of the starting material, while simultaneously introducing potential doping sites for Eu 2+ by incorporating divalent alkaline earth cations (Ca 2+ /Sr 2+ ). Upon excitation of Eu 2+ doped samples with blue light, strong luminescence due to parity-allowed 4f 6 ( 7 F)5d 1 →4f 7 ( 8 S 7/2 ) transition can be observed in the red (Ca 2 Li 6 P 4 N 10 : Eu 2+ : λ max =626 nm), yellow/orange (Ca 2.7 Li 4.6 P 4 N 10 : Eu 2+ : λ max1 =506 nm, λ max2 =592 nm and Sr 3 Li 4 P 4 N 10 : Eu 2+ : λ max =596 nm) and green (Ca 4 Li 2 P 4 N 10 : Eu 2+ : λ max =546 nm) spectral regions of the visible light. The compounds presented, together with the simplified synthetic approach, demonstrate the significant potential of ion exchange on Li ion conductors for the development of novel nitridophosphates in the future.}, archive = {J_ANGEW}, author = {Reinhard M. Pritzl and Amalina T. Buda and Kristian Witthaut and Peter J. Schmidt and Wolfgang Schnick}, doi = {10.1002/anie.202420565}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420565}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Adamantane-type nitridophosphate phosphors AExLi10−2xP4N10: Eu2+ via medium-pressure ion-exchange reactions}, volume = {64}, year = {2025}, }
• (2025). Catalytic asymmetric 1,4-hydrocarbonation of 1,3-enynes via Photoredox/Cobalt/Chromium triple catalysis. ANGEW, 64(9), e202420563. (www)

  @article{ , abstract = {A synergistic photoredox/cobalt/chromium triple catalysis system for regioselective, enantioselective, and diastereoselective 1,4-hydrocarbonation of readily available 1,3-enyne precursors was explored, providing a modular synthetic platform for various trisubstituted axially chiral allenes bearing an extra central chirality. The protocol features a broad substrate scope, good functional group tolerance, excellent selectivity, and mild reaction conditions. Furthermore, a possible reaction mechanism is proposed based on numerous control experiments and density functional theory calculations.}, archive = {J_ANGEW}, author = {Ju-Song Yang and Xing-Yu Wang and Yong-Yao Li and Fu-Min Zhang and Xiao-Ming Zhang and Yong-Qiang Tu}, doi = {10.1002/anie.202420563}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420563}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic asymmetric 1,4-hydrocarbonation of 1,3-enynes via Photoredox/Cobalt/Chromium triple catalysis}, volume = {64}, year = {2025}, }
• (2025). Isolated neutral organic radical unveiled solvent-radical interaction in highly reducing photocatalysis. ANGEW, 64(9), e202420483. (www)

  @article{ , abstract = {Diffusion-limited kinetics is a key mechanistic debate when consecutive photoelectron transfer (conPET) is discussed in photoredox catalysis. In situ generated organic photoactive radicals can access catalytic systems as reducing as alkaline metals that can activate remarkably stable bonds. However, in many cases, the extremely short-lived transient nature of these doublet state open-shell species has led to debatable mechanistic studies, hindering adoption and development. Herein, we document the use of an isolated and stable neutral organic n PrDMQA radical as a highly photoreducing species. The isolated radical offers a unique platform to investigate the mechanism behind the photocatalytic activity of organic photocatalyst radicals. The involvement of reduced solvent is observed, formed by single electron transfer (SET) between the short-lived excited state n PrDMQA radical and the solvent. In our detailed mechanistic studies, spectroscopic and chemical affirmation of solvent reduction is strongly evident. Reduction of aryl halides, including difluoroarenes is presented as a model study of the conPET method. Further, the activation of N 2 O, a greenhouse gas that is yet to be activated by photoredox catalysis, is showcased in the absence of a transition metal.}, archive = {J_ANGEW}, author = {Aslam C. Shaikh and Md Mubarak Hossain and Jules Moutet and Anshu Kumar and Benjamin Thompson and Vanessa M. Huxter and Thomas L. Gianetti}, doi = {10.1002/anie.202420483}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420483}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isolated neutral organic radical unveiled solvent-radical interaction in highly reducing photocatalysis}, volume = {64}, year = {2025}, }
• (2025). A stable open-shelled au26 nanocluster with remarkable performance in selective oxidation of benzyl alcohol. ANGEW, 64(9), e202420314. (www)

  @article{ , abstract = {Open metal sites are crucial in catalysis. We have used a “loose coordination strategy” (LCS) to preorganize open metal sites in gold cluster catalysts. A gold nanocluster with composition of [Au 26 (3,4-Me 2 -Ph-form) 9 ( i Pr 2 -imy) 3 (Me 2 S)](BF 4 ) 2 ( i Pr 2 -imy=1,3-Diisopropylimidazolium tetrafluoroborate, 3,4-Me 2 -Ph-form=N,N′-Di(3,4-dimethyl-phenyl)formamidine) ( Au 26 ) has been obtained by one pot synthesis, i.e. the direct reduction of Me 2 SAuCl in the presence of N-heterocyclic carbenes and amidinate ligands. ESI-TOF-MS reveals that the Me 2 S ligand is detached from the cluster to form open sites. The accessibility of the exposed Au atoms has been confirmed quantitatively by luminescent titration with 2-naphthalenethiol. Surprisingly, Au 26 has 15 valence electrons, and the presence of an unpaired electron is confirmed by superconducting quantum interference device (SQUID) and electron paramagnetic resonance (EPR). This open-shelled Au 26 not only shows unexpected high stability but also exhibits excellent catalytic performance toward the selective oxidation of benzyl alcohol to benzaldehyde, achieving a remarkable turnover number up to 100670.}, archive = {J_ANGEW}, author = {Yuan-Yuan Dong and Chun-Yu Liu and Wan-Qi Shi and Zong-Jie Guan and Quan-Ming Wang}, doi = {10.1002/anie.202420314}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A stable open-shelled au26 nanocluster with remarkable performance in selective oxidation of benzyl alcohol}, volume = {64}, year = {2025}, }
• (2025). Light-driven stepwise reduction of aliphatic carboxylic esters to aldehydes and alcohols. ANGEW, 64(9), e202420084. (www)

  @article{ , abstract = {The reduction of carboxylic esters to aldehydes and alcohols is a fundamental functional group transformation in chemistry. However, the inertness of carbonyl group and the instability of ketyl radical anion intermediate impede the reduction of carboxylic esters via photochemical strategy. Herein, we described the reduction of aliphatic carboxylic esters with synergistic dual photocatalysis via phenolate-catalyzed single electron transfer process and thiol-catalyzed hydrogen atom transfer process. The competitive back electron transfer process was effectively inhibited by protonation of the ketyl-type radical anion. This protocol enabled the efficient reduction of carboxylic esters to alcohols under mild conditions. By interruption of the reduction with prolinol, the step-controlled reduction of carboxylic esters to aldehydes was accomplished. The developed process was also successfully applied to the preparation of deuterated alcohols and aldehydes from esters with D 2 O as the deuterium source.}, archive = {J_ANGEW}, author = {Delian Wei and Jiawei Bu and Shengfu Zhang and Shiyu Chen and Ling Yue and Xipan Li and Kangjiang Liang and Chengfeng Xia}, doi = {10.1002/anie.202420084}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202420084}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-driven stepwise reduction of aliphatic carboxylic esters to aldehydes and alcohols}, volume = {64}, year = {2025}, }
• (2025). Single crystalline, non-stoichiometric hydrogen-bonded organic frameworks showing versatile fluorescence depending on composition ratios and distributions. ANGEW, 64(9), e202419992. (www)

  @article{ , abstract = {Hydrogen-bonded organic frameworks (HOFs) composed of multicomponent molecules in a non-stoichiometric composition have drawn great interest due to their tunable properties. However, the photobehavior of the single crystals of such mixed HOFs has not been explored. Here, we report on the synthesis, characterization and photobehavior of single crystalline non-stoichiometric HOFs (NS-HOFs). NS-HOFs ( B T N T -1 ) with various composition ratios were successfully obtained as single crystals from two analogue tetratopic carboxylic acids, possessing naphthalene and benzothiadiazole cores ( NTTA and BTTA , respectively). The heterogeneous distribution of the components was thoroughly confirmed by time-resolved fluorescence microscopy and local crystallographic analysis using focused synchrotron X-ray radiation. The versatile fluorescence of B T N T -1 behavior depends on the composition ratio and distribution of the component in the single crystals. We observed not only fluorescence bands with various colors such as purple, blue, green and white, depending on the composition ratios, but also different emission bands from a single crystal. We provide details on their emission lifetimes following the composition, emission color and targeted region on the crystal. This work is the first example of single crystal studies applied to organic porous co-crystals and demonstrates unique and versatile optical properties of carboxylic acid-based NS-HOFs. The results provide a concept of creating functional mixed porous materials capable of different and tunable optical properties.}, archive = {J_ANGEW}, author = {Taito Hashimoto and Mario de la Hoz Tomás and Ryusei Oketani and Boiko Cohen and Miki Naruoka and Norimitsu Tohnai and Abderrazzak Douhal and Ichiro Hisaki}, doi = {10.1002/anie.202419992}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419992}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single crystalline, non-stoichiometric hydrogen-bonded organic frameworks showing versatile fluorescence depending on composition ratios and distributions}, volume = {64}, year = {2025}, }
• (2025). Selenium-substitution strategy for enhanced mobility, tunable bandgap, and improved electrochemical energy storage in semiconducting conjugated coordination polymers. ANGEW, 64(9), e202419865. (www)

  @article{ , abstract = {Conjugated coordination polymers (c-CPs), a novel class of organic–inorganic hybrid materials, are distinguished by their unique structural characteristics and exceptional charge transport properties. The electronic properties of these materials are critically determined by the constituting coordination atoms, with electron-rich selenol ligands emerging as promising candidates for constructing high-mobility semiconducting c-CPs. Despite their potential, c-CPs incorporating selenium-substituted ligands remain scarce due to the synthetic challenges associated with both the ligands and the coordination polymers. In this study, we successfully synthesized a new tetraselenol-hydroxyquinone (TSHQ) ligand using a “4+2” design strategy and developed a semiconducting three-dimensional Ag−Se coordination polymer, Ag 4 TSHQ. Ag 4 TSHQ exhibits room-temperature electrical conductivity of up to 1.6 S/m and shares the same structural topology as Ag 4 TTHQ (TTHQ=tetrathiol-hydroxyquinone), enabling precise band gap modulation from 0.6 eV to 1.5 eV via a mixed-ligand approach. Time-resolved terahertz spectroscopy reveals that the charge mobility of Ag 4 TSHQ in the dc limit is ~350 cm 2 /V ⋅ s, which is twice that of its sulfur counterpart, Ag 4 TTHQ. Furthermore, our evaluations of their electrochemical energy storage capabilities demonstrate that Ag 4 TSHQ effectively utilizes its redox potential, achieving a remarkable specific capacitance of up to 340 F/g-significantly outperforming Ag 4 TTHQ, which has a capacitance of 294 F/g. These findings underscore the potential of selenium-ligand-based c-CPs for optoelectronic applications and energy storage technologies.}, archive = {J_ANGEW}, author = {Sha Wu and Xing Huang and Shuai Fu and Ze Li and Siping Yin and Wenkai Liao and Mingchao Wang and Yang Lu and Mischa Bonn and Yimeng Sun and Xinliang Feng and Wei Xu}, doi = {10.1002/anie.202419865}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419865}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selenium-substitution strategy for enhanced mobility, tunable bandgap, and improved electrochemical energy storage in semiconducting conjugated coordination polymers}, volume = {64}, year = {2025}, }
• (2025). Next-generation photosensitizers: Cyanine-carborane salts for superior photodynamic therapy of metastatic cancer. ANGEW, 64(9), e202419759. (www)

  @article{ , abstract = {Photodynamic therapy (PDT) has emerged as a promising targeted treatment for cancer. However, current PDT is limited by low tissue penetration, insufficient phototoxicity (toxicity with light irradiation), and undesirable cytotoxicity (toxicity without light irradiation). Here, we report the discovery of cyanine-carborane salts as potent photosensitizers (PSs) that harness the near-infrared (NIR) absorbing [cyanine + ] with the inertness of [carborane − ]. The implementation of [cyanine + ] [carborane − ] salts dramatically enhance cancer targeting of the PSs and decrease cytotoxicity. We characterize the cellular uptake of the cyanine-carborane PSs, organelle localization, generation of reactive oxygen species (ROS) with the ability to cogenerate multiple ROS species, suppression of pro-metastatic pathways, and activation of apoptotic pathways. We further demonstrate the ability of optimized PSs to eliminate tumors in vivo using an orthotopic mouse model of breast cancer. These newly developed [cyanine + ] [carborane − ] salt PSs introduce a potent therapeutic approach against aggressive breast cancer while decreasing side effects.}, archive = {J_ANGEW}, author = {Amir Roshanzadeh and Hyllana C. D. Medeiros and Christopher K. Herrera and Carson Malhado and Anton W. Tomich and Steven P. Fisher and Sergio O. Lovera and Matthew Bates and Vincent Lavallo and Richard R. Lunt and Sophia Y. Lunt}, doi = {10.1002/anie.202419759}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419759}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Next-generation photosensitizers: Cyanine-carborane salts for superior photodynamic therapy of metastatic cancer}, volume = {64}, year = {2025}, }
• (2025). Polymer ligands with multi-nitrogen heterocyclic carbenes for enhanced stability and reactivity in nanoparticle surface functionalization. ANGEW, 64(9), e202419640. (www)

  @article{ , abstract = {Nitrogen heterocyclic carbenes (NHCs) are emerging as effective substitutes for conventional thiol ligands in surface functionalization of nanoparticles (NPs), offering exceptional stability to NPs under harsh conditions. However, the highly reactive feature of NHCs limits their use in introducing chemically active groups onto the NP surface. Herein, we develop a general yet robust strategy for the efficient surface functionalization of NPs with copolymer ligands bearing various functional groups. The polymer ligands consist of a multiple NHCs block, utilized for surface binding on NPs, alongside a poly(reactive ester) block intended for incorporating functional groups. The multiple NHCs block enables NPs with excellent colloidal stability across a broader range of pH values (0–14), temperature variations (–78 °C-100 °C), and electrolyte concentrations (0–1000 mM). Through the in situ ammonolysis of the poly(reactive ester) block, various active functional groups can be individually or together introduced on the NP surface. We further demonstrate the chemical reactivity of these functionalized NPs, including addition polymerization, Diels–Alder and Schiff base reactions. This method is applicable to various types of NPs, including metal NPs, metal oxide NPs, and even upconversion NPs, thereby paving new pathways for the design and creation of nanoparticle-based functional materials.}, archive = {J_ANGEW}, author = {Jing Tao and Di Zheng and Yutian Tang and Huibin He and Yan Zhang and Yanqiong Yang and Liwei Dai and Huaining Zha and Yutao Sang and Zhihong Nie}, doi = {10.1002/anie.202419640}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polymer ligands with multi-nitrogen heterocyclic carbenes for enhanced stability and reactivity in nanoparticle surface functionalization}, volume = {64}, year = {2025}, }
• (2025). Harnessing multi-center-2-electron bonds for carbene metal-hydride nanocluster catalysis. ANGEW, 64(9), e202419537. (www)

  @article{ , abstract = {N -Heterocyclic carbene (NHC) ligands possess the ability to stabilize metal-based nanomaterials for a broad range of applications. With respect to metal-hydride nanomaterials, however, carbenes are rare, which is surprising if one considers the importance of metal-hydride bonds across the chemical sciences. In this study, we introduce a bottom-up approach that leverages preexisting metal-metal m-center-n-electron ( m c- n e) bonds to access a highly stable cyclic(alkyl)amino carbene (CAAC) copper-hydride nanocluster, [(CAAC) 6 Cu 14 H 12 ][OTf] 2 with superior stability compared to Stryker's reagent, a popular commercial phosphine-based copper hydride catalyst. Density functional theory (DFT) calculations reveal that the enhanced stability stems from hydride-to-ligand backbonding with the π-accepting carbene. This new cluster emerges as an efficient and selective copper-hydride pre-catalyst, thereby providing a bench-stable alternative for catalytic applications.}, archive = {J_ANGEW}, author = {Quentin Pessemesse and Skyler D. Mendoza and Jesse L. Peltier and Elguja Gojiashvili and Anne K. Ravn and Jan Lorkowski and Milan Gembicky and Sourav S. Bera and Pierre-Adrien Payard and Keary M. Engle and Rodolphe Jazzar}, doi = {10.1002/anie.202419537}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419537}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing multi-center-2-electron bonds for carbene metal-hydride nanocluster catalysis}, volume = {64}, year = {2025}, }
• (2025). Converting Fe−N−C single-atom catalyst to a new FeNxSey cluster catalyst for proton-exchange membrane fuel cells. ANGEW, 64(9), e202419501. (www)

  @article{ , abstract = {Iron-nitrogen-carbon (Fe−N−C) single-atom catalyst is the most promising alternative to platinum catalyst for proton-exchange membrane fuel cells (PEMFCs), however its high performance cannot be maintained for a long enough time in device operation. The construction of a new Fe coordination environment that is completely different from the square-planar Fe−N 4 configuration in classic Fe−N−C catalyst is expected to break the current stability limits of Pt-free catalysts, which however remains unexplored. Here, we report, for the first time, the conversion of Fe−N−C catalyst to a new FeN x Se y cluster catalyst, where the active Fe sites are three-dimensionally (3D) co-coordinated by N and Se atoms. Due to this unique Fe coordination configuration, the FeN x Se y catalyst exhibits much better 4e − ORR activity and selectivity than the state-of-the-art Fe−N−C catalyst. Specifically, the yields of hydrogen peroxide (H 2 O 2 ) and ⋅OH radicals on the FeN x Se y catalyst are only one-quarter and one-third of that on the Fe−N−C counterpart, respectively. Therefore, the FeN x Se y catalyst exhibits outstanding cyclic stability, losing only 10 mV in half-wave potential E 1/2 after 10,000 potential cycles, much smaller than that of the Fe−N−C catalyst (56 mV), representing the most stable Pt-free catalysts ever reported for PEMFCs. More significantly, the 3D co-coordination structure effectively inhibits the Fe demetallization of the FeN x Se y catalyst in the presence of H 2 O 2 . As a result, the FeN x Se y based PEMFC shows excellent durability, with the current density attenuation significantly lower than that of the Fe−N−C based device after accelerated durability testing. Our work provides guidance for the development of next-generation Pt-free catalysts for PEMFCs.}, archive = {J_ANGEW}, author = {Yang Zhao and Pengfei Yin and Yuanyuan Yang and Ruguang Wang and Cairong Gong and Jisi Li and Jiaxin Guo and Quanlu Wang and Tao Ling}, doi = {10.1002/anie.202419501}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419501}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Converting Fe−N−C single-atom catalyst to a new FeNxSey cluster catalyst for proton-exchange membrane fuel cells}, volume = {64}, year = {2025}, }
• (2025). Activatable photosensitizer prodrug for self-amplified immune therapy via pyroptosis. ANGEW, 64(9), e202419376. (www)

  @article{ , abstract = {Immunotherapy is a promising cancer treatment, but its application is hindered by tumors’ low immunogenicity and the difficulty of immune cell infiltration. Here, to address above issues and achieve targeted tumor treatment, we designed the first activated small molecule photosensitizer immune-prodrug HDIM based on pyroptosis, and proposed a self-amplified immune therapy strategy (SITS) for enhanced tumor therapy. HDIM can be specifically activated by the tumor hypoxia and then simultaneously initiate immuno-therapy and photodynamic therapy (PDT)-induced pyroptosis with NIR laser irradiation. Mechanism study demonstrated that the immunogenicity in tumor can be significantly enhanced by HDIM -induced pyroptosis and immune cells are recruited, thus effectively amplifying the therapeutic effect of the released immune drugs. As proof of application, we have utilized HDIM for primary tumor and distant tumor therapy. And the experiment results showed that compared to current monotherapy as well as simple combination therapy, the photosensitizer prodrug HDIM exhibited much superior tumor treatment effect owing to its synchronous activation of pyroptosis and immuno-therapy in tumor.}, archive = {J_ANGEW}, author = {Ping-Zhao Liang and Li-Li Ren and Ying-Hong Yan and Zhe Li and Fei-Yu Yang and Tian-Bing Ren and Lin Yuan and Xiao-Bing Zhang}, doi = {10.1002/anie.202419376}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419376}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activatable photosensitizer prodrug for self-amplified immune therapy via pyroptosis}, volume = {64}, year = {2025}, }
• (2025). A highly dispersed heterogeneous cobalt catalyst for efficient domino hydroformylation reductive amination of olefins. ANGEW, 64(9), e202419370. (www)

  @article{ , abstract = {The hydroaminomethylation of alkenes using CO and H 2 proceeds efficiently in the presence of a heterogeneous Co−N/C catalyst with highly dispersed metal centers. Various secondary and tertiary amines can be effectively synthesized from cyclic and linear aliphatic alkenes using this specific material. The active sites of the optimal catalyst result from the synergistic effect of atomically dispersed Co sites with their surrounding N atoms, and the high surface area as well as structural defects of the NC support. The broad applicability (>54 examples), including pharmaceutically relevant molecules, together with the high activity and reusability, underline the general applicability of this catalytic system.}, archive = {J_ANGEW}, author = {Kangkang Sun and Tianyue Su and Guo-Ping Lu and Robert Franke and Helfried Neumann and Matthias Beller}, doi = {10.1002/anie.202419370}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202419370}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly dispersed heterogeneous cobalt catalyst for efficient domino hydroformylation reductive amination of olefins}, volume = {64}, year = {2025}, }
• (2025). PH-responsive polyglycerol nanogels for periodontitis treatment through antibacterial and pro-angiogenesis action. ANGEW, 64(9), e202418882. (www)

  @article{ , abstract = {Periodontitis is a microbe-driven inflammatory disease leading to bone resorption and tissue destruction. We propose a dual-functional nanogel complex armed with the antimicrobial drug triclosan (TCS) and the pro-angiogenesis medication deferoxamine (DFO) for combating microbial pathogens and promoting tissue regeneration. The nanogel system (NG-TCS-DFO) that we fabricated from linear polyglycerol exhibits well-defined spherical morphology and a positively charged surface for bacteria adhesion. The rapid and sustained degradation of NG-TCS-DFO in the acidic environment of an infection site induces the on-demand release of TCS and DFO. The NG-TCS-DFO shows potent bacteria elimination of the gingivitis-causing bacteria Porphyromonas gingivalis in both planktonic (99.9 %) and biofilm (99 %) states. Furthermore, the NG-TCS-DFO can promote vascularization and migration of human umbilical vein endothelial cells (HUVECs). Contributing to the synergistic effect of TCS and DFO, the NG-TCS-DFO demonstrates significant bone tissue regeneration and accelerated healing of periodontitis in vivo. This polyglycerol-based nanogel may therefore offer smart combined delivery of multiple therapeutics against bacteria-driven diseases.}, archive = {J_ANGEW}, author = {Guoxin Ma and Ke Xu and Leixiao Yu and Rainer Haag}, doi = {10.1002/anie.202418882}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202418882}, shortjournal = {Angew. Chem. Int. Edit.}, title = {PH-responsive polyglycerol nanogels for periodontitis treatment through antibacterial and pro-angiogenesis action}, volume = {64}, year = {2025}, }
• (2025). Nanocrystals with aggregate anionic structure enable ion transport decoupling of chain segment movement in poly(ethylene oxide) electrolytes. ANGEW, 64(9), e202418783. (www)

  @article{ , abstract = {All-solid-state polymer electrolytes are promising for lithium batteries, but Li + transport in these electrolytes relies on amorphous chain segment movement, leading to low Li + mobility and poor mechanical strength. Here we propose a novel Li + transport mechanism mediated by PEO 3 :LiBF 4 nanocrystals (NCPB) with the aggregate (AGG) anionic structure, which enables a change from amorphous to crystalline phase dominated ion transport in all-solid-state PEO/LiBF 4 electrolyte. Experiments and simulations reveal that the interaction between Li + and F in NCPB with AGG anionic structure simultaneously restricts anion transport and reorients anions within the free volume of NCPB, resulting in a three-coordination intermediate to facilitate Li + transport. The unique Li + transport mechanism through NCPB makes the PEO/LiBF 4 electrolyte with a high Li + transference number (0.73) and remarkably increased mechanical strength (storage modulus >100 MPa) at 45 °C. As a result, the Li|LiFePO 4 batteries with the ultrathin self-supported PEO/LiBF 4 electrolyte (10 μm) exhibit significantly improved cycle life (97 % @ 468 cycles) compared to those with PEO/LiTFSI electrolyte (failed @ 68 cycles). This work demonstrates a novel ion transport mechanism for achieving selective and rapid Li + transport.}, archive = {J_ANGEW}, author = {Jinze Hou and Weiwei Xie and Long Shang and Shuang Wu and Yuewei Cui and Yixin Li and Zhenhua Yan and Kai Zhang and Yong Lu and Jun Chen}, doi = {10.1002/anie.202418783}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202418783}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanocrystals with aggregate anionic structure enable ion transport decoupling of chain segment movement in poly(ethylene oxide) electrolytes}, volume = {64}, year = {2025}, }
• (2025). Dynamic, single-cell monitoring of RNA modifications response to viral infection using a genetically encoded live-cell RNA methylation sensor. ANGEW, 64(9), e202418003. (www)

  @article{ , abstract = {RNA modifications, such as N6-methylation of adenosine (m 6 A), serve as key regulators of cellular behaviors, and are highly dynamic; however, tools for dynamic monitoring of RNA modifications in live cells are lacking. Here, we develop a genetically encoded live-cell RNA methylation sensor that can dynamically monitor RNA m 6 A level at single-cell resolution. The sensor senses RNA m 6 A in cells via affinity-induced cytoplasmic retention using a nuclear location sequence-fused m 6 A reader. It allows for simultaneously measure RNA m 6 A dynamics and viral invasion at single-cell level. Based on the single-cell analytical tool, we found that SARS-CoV-2 infection enhances host-cell RNA m 6 A level, and high-level RNA m 6 A modification in host cells, in turn, facilitates viral infection. Particularly, Omicron, a variant of SARS-CoV-2, that features as high infection capacity, however, exhibits a reduced facilitation of m 6 A modification in host cells. In addition, the sensor can estimate viral inhibition via measuring cellular m 6 A level, that was explored for screening potential antiviral drugs. The methylation sensor can serve for elucidating the interplay between pathogens and host-cell epigenetics at single-cell level.}, archive = {J_ANGEW}, author = {Ting Zhang and Hao Yang and Quanwei Yu and Yong Zhang and Yue Zhang and Xianglin Zhu and Xuhan Xia and Feng Li and Ruijie Deng}, doi = {10.1002/anie.202418003}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202418003}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic, single-cell monitoring of RNA modifications response to viral infection using a genetically encoded live-cell RNA methylation sensor}, volume = {64}, year = {2025}, }
• (2025). Optimization of structure-guided development of chemical probes for the pseudoknot RNA of the frameshift element in SARS-CoV-2. ANGEW, 64(9), e202417961. (www)

  @article{ , abstract = {Targeting the RNA genome of SARS-CoV-2 is a viable option for antiviral drug development. We explored three ligand binding sites of the core pseudoknot RNA of the SARS-CoV-2 frameshift element. We iteratively optimized ligands, based on improved affinities, targeting these binding sites and report on structural and dynamic properties of the three identified binding sites. Available experimental 3D structures of the pseudoknot element were compared to SAXS and NMR data to validate its dominant folding state in solution. In order to experimentally map in silico predicted binding sites, NMR assignments of the majority of nucleobases were achieved by segmental labeling of the pseudoknot RNA and isotope-filtered NMR experiments at 1.2 GHz, demonstrating the value of NMR spectroscopy to supplement modelling and docking data. Optimized ligands with enhanced affinity were shown to specifically inhibit frameshifting without affecting 0-frame translation in cell-free translation assays, establishing the frameshift element as target for drug-like ligands of low molecular weight.}, archive = {J_ANGEW}, author = {Betül Ceylan and Jennifer Adam and Sabrina Toews and Frank Kaiser and Jonas Dörr and Daniel Scheppa and Jan-Niklas Tants and Alexandria Smart and Julian Schoth and Susanne Philipp and Elke Stirnal and Jan Ferner and Christian Richter and Sridhar Sreeramulu and Neva Caliskan and Andreas Schlundt and Julia E. Weigand and Michael Göbel and Anna Wacker and Harald Schwalbe}, doi = {10.1002/anie.202417961}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202417961}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimization of structure-guided development of chemical probes for the pseudoknot RNA of the frameshift element in SARS-CoV-2}, volume = {64}, year = {2025}, }
• (2025). Scalable atomic-layer tailoring of abundant oxide supports unlocks superior interfaces for low-metal-loading dehydrogenation. ANGEW, 64(9), e202417598. (www)

  @article{ , abstract = {Liquid organic hydrogen carriers (LOHCs) offer a promising solution for global hydrogen infrastructure, but their practical application faces two key challenges: sluggish dehydrogenation processes and the reliance on catalysts with high noble metal loadings. This study presents a scalable approach to reduce noble metal usage while maintaining high catalytic activity. We synthesized an ultralow Pt content (0.1 wt %) catalyst using γ-Al 2 O 3 -based pellet support with atomic layer deposition (ALD) of TiO 2 . Advanced characterization techniques reveal that the thin ALD-TiO 2 shell provides a heterogeneous interface, confining electronically rich Pt-nanoparticle ensembles. The catalyst outperforms both equivalent Pt-content catalysts and a commercial 0.5 wt % Pt/γ-Al 2 O 3 catalyst in homocyclic LOHC dehydrogenation. This study provides insights into the beneficial role of ALD-engineered interfaces for catalytic supports and offers an efficient approach for scalable production of low-noble-metal-content catalysts, with implications for various catalytic processes.}, archive = {J_ANGEW}, author = {Yeonsu Kwak and Yu-Jin Lee and Seongeun Moon and Kimoon Lee and Safira Ramadhani and Eui-Rim On and Chang-il Ahn and Son-Jong Hwang and Hyuntae Sohn and Hyangsoo Jeong and Suk Woo Nam and Chang Won Yoon and Yongmin Kim}, doi = {10.1002/anie.202417598}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202417598}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable atomic-layer tailoring of abundant oxide supports unlocks superior interfaces for low-metal-loading dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Cu(I)-induced G-quartets: Robust supramolecular polymers exhibiting heating-induced aqueous phase transitions into gel or precipitate. ANGEW, 64(9), e202417508. (www)

  @article{ , abstract = {Certain proteins and synthetic covalent polymers experience aqueous phase transitions, driving functional self-assembly. Herein, we unveil the ability of supramolecular polymers (SPs) formed by G 4 .Cu + to undergo heating-induced unexpected aqueous phase transitions. For the first time, guided by Cu + , guanosine (G) formed a highly stable G-quartet (G 4 .Cu + )/G-quadruplex as a non-canonical DNA secondary structure with temperature tolerance, distinct from the well-known G 4 .K + . The G 4 .Cu + self-assembled in water through π-π stacking, metallophilic and hydrophobic interactions, forming thermally robust SPs. This enhanced stability is attributed to the stronger coordination of Cu + to four carbonyl oxygens of G-quartet and the presence of Cu + - - -Cu + attractive metallophilic interactions in Cu + -induced G-quadruplex, exhibiting a significantly higher interaction energy than K + as determined computationally. Remarkably, the aqueous SP solution exhibited heating-induced phase transitions—forming a hydrogel through dehydration-driven crosslinking of SPs below cloud temperature ( T cp ) and a hydrophobic collapse-induced solid precipitate above T cp , showcasing a lower critical solution temperature (LCST) behavior. Notably, this LCST behavior of G 4 .Cu + SP originates from biomolecular functionality rather than commonly exploited thermo-responsive oligoethylene glycols with supramolecular assemblies. Furthermore, exploiting the redox reversibility of Cu + /Cu 2+ , we demonstrated control over the assembly and disassembly of G-quartets/G-quadruplex and gelation reversibly.}, archive = {J_ANGEW}, author = {Nihar Sahu and Chandrakanta Guchhait and Indrajit Mohanta and Vembanan Suriyaa and Bimalendu Adhikari}, doi = {10.1002/anie.202417508}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202417508}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cu(I)-induced G-quartets: Robust supramolecular polymers exhibiting heating-induced aqueous phase transitions into gel or precipitate}, volume = {64}, year = {2025}, }
• (2025). Aryl-acetylene layered hybrid perovskites in photovoltaics. ANGEW, 64(9), e202417432. (www)

  @article{ , abstract = {Metal halide perovskites have shown exceptional potential in converting solar energy to electric power in photovoltaics, yet their application is hampered by limited operational stability. This stimulated the development of hybrid layered (two-dimensional, 2D) halide perovskites based on hydrophobic organic spacers, templating perovskite slabs, as a more stable alternative. However, conventional organic spacer cations are electronically insulating, resulting in charge confinement within the inorganic slabs, thus limiting their functionality. This can be ameliorated by extending the π-conjugation of the spacer cations. We demonstrate the capacity to access Ruddlesden-Popper and Dion-Jacobson 2D perovskites incorporating for the first time aryl-acetylene-based (4-ethynylphenyl)methylammonium (BMAA) and buta-1,3-diyne-1,4-diylbis(4,1-phenylene)dimethylammonium (BDAA) spacers, respectively. We assess their unique opto(electro)ionic characteristics by a combination of techniques and apply them in mixed-dimensional perovskite solar cells that show superior device performances with a power conversion efficiency of up to 23 % and higher operational stability, opening the way for multifunctionality in layered hybrid materials and their application.}, archive = {J_ANGEW}, author = {Ghewa AlSabeh and Vladislav Slama and Ming Ren and Masaud Almalki and Lukas Pfeifer and Dominik J. Kubicki and Paul Zimmermann and Alexander Hinderhofer and Fabiola Faini and Davide Moia and Mostafa Othman and Felix T. Eickemeyer and Virginia Carnevali and Nikolaos Lempesis and Andrea Vezzosi and Fatemeh Ansari and Frank Schreiber and Joachim Maier and Christian M. Wolff and Aïcha Hessler-Wyser and Christophe Ballif and Giulia Grancini and Ursula Rothlisberger and Michael Grätzel and Jovana V. Milić}, doi = {10.1002/anie.202417432}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202417432}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aryl-acetylene layered hybrid perovskites in photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Cation migration-induced lattice oxygen oxidation in spinel oxide for superior oxygen evolution reaction. ANGEW, 64(9), e202416757. (www)

  @article{ , abstract = {Activating the lattice oxygen can significantly improve the kinetics of oxygen evolution reaction (OER), however, it often results in reduced stability due to the bulk structure degradation. Here, we develop a spinel Fe 0.3 Co 0.9 Cr 1.8 O 4 with active lattice oxygen by high-throughput methods, achieving high OER activity and stability, superior to the benchmark IrO 2 . The oxide exhibits an ultralow overpotential (190 mV at 10 mA cm −2 ) with outstanding stability for over 170 h at 100 mA cm −2 . Soft X-ray absorption- and Raman-spectroscopies, combined with 18 O isotope-labelling experiments, reveal that lattice oxygen activation is driven by Cr oxidation, which induces a cation migration from CrO 6 octahedrons to CrO 4 tetrahedrons. The geometry conversion creates accessible non-bonding oxygen states, crucial for lattice oxygen oxidation. Upon oxidation, peroxo O−O bond is formed and further stabilized by Cr 6+ (CrO 4 tetrahedra) via dimerization. This work establishes a new approach for designing efficient catalysts that feature active and stable lattice oxygen without compromising structural integrity.}, archive = {J_ANGEW}, author = {Mahmoud G. Ahmed and Ying Fan Tay and Xiao Chi and Ahmed S. Razeen and Yanan Fang and Mengyuan Zhang and Anqi Sng and Sing Yang Chiam and Andrivo Rusydi and Lydia H. Wong}, doi = {10.1002/anie.202416757}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202416757}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cation migration-induced lattice oxygen oxidation in spinel oxide for superior oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Constructing donor-acceptor covalent organic frameworks for highly efficient H2O2 photosynthesis coupled with oxidative organic transformations. ANGEW, 64(9), e202416240. (www)

  @article{ , abstract = {The development of photocatalytic systems that enable the simultaneous production of H 2 O 2 and value-added organic chemicals presents a dual advantage: generating valuable products while maximizing the utilization of solar energy. Despite the potential, there are relatively few reports on photocatalysts capable of such dual functions. In this study, we synthesized a series of donor-acceptor covalent organic frameworks (COFs), designated as JUC-675 to JUC-677, to explore their photocatalytic efficiency in the co-production of H 2 O 2 and N-benzylbenzaldimine (BBAD). Among them, JUC-675 exhibited exceptional performance, achieving a H 2 O 2 production rate of 22.8 mmol g −1 h −1 with an apparent quantum yield of 15.7 %, and its solar-to-chemical conversion efficiency was calculated to be 1.09 %, marking it as the most effective COF-based photocatalyst reported to date. Additionally, JUC-675 demonstrated a high selectivity (99.9 %) and yield (96 %) for BBAD in the oxidative coupling of benzylamine. The underlying reaction mechanism was thoroughly investigated through validation experiments and density functional theory (DFT) calculations. This work represents a significant advancement in the design of COF-based photocatalysts and the development of efficient dual-function photocatalytic platforms, offering new insights and methodologies for enhanced solar energy utilization and the synthesis of value-added products.}, archive = {J_ANGEW}, author = {Jianchuan Liu and Chao Tuo and Wei-Yun Xiao and Ming-Yu Qi and Yusran Yusran and Zitao Wang and Hui Li and Chunsheng Guo and Jialong Song and Shilun Qiu and Yi-Jun Xu and Qianrong Fang}, doi = {10.1002/anie.202416240}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202416240}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing donor-acceptor covalent organic frameworks for highly efficient H2O2 photosynthesis coupled with oxidative organic transformations}, volume = {64}, year = {2025}, }
• (2025). Deciphering polymer interactions in bioconjugates with different architectures by structural analysis via time-resolved limited proteolysis mass spectrometry. ANGEW, 64(9), e202415354. (www)

  @article{ , abstract = {Therapeutic proteins are commonly conjugated with polymers to modulate their pharmacokinetics but often lack a description of the polymer-protein interaction. We deployed limited proteolysis mass spectrometry (LiP-MS) to reveal the interaction of polyethylene glycol (PEG) and PEG alternative polymers with interferon-α2a (IFN). Target conjugates were digested with the specific protease trypsin and a “heavy” 15 N-IFN wild type (IFN-WT) for time-resolved quantification of the cleavage dynamics. Interactions between IFN-α2a and its high-affinity receptor were detailed by LiP-MS. Then, 10 kDa polymers of PEG, linear polyglycerol (LPG), and poly(2-oxazoline) (POX) with two different cyclooctyne linkers (BCN/DBCO) were used for site-specific bioconjugation to azide functionalized IFN-α2a. Tryptic events at each cleavage site and in different structural environments (loops/helices) were compared. PEG and LPG were similar, and POX showed a reduced interaction profile with the IFN-α2a surface. All-atom molecular dynamics simulations of IFN-DBCO-polymer conjugates revealed distinct and transient (below 50 ns) protein-interaction profiles for PEG, LPG, and POX. Cleavage dynamics of IFN-polymer conjugates from the BCN handle were homogeneous, pointing to a more conserved IFN structure than DBCO-polymer conjugates. In summary, time-resolved LiP-MS for quantification of cleavage events enhances the structural understanding of transient IFN-polymer interactions, which may be extended to other bioconjugate types.}, archive = {J_ANGEW}, author = {Prisca Hamm and Marc D. Driessen and Niklas Hauptstein and Josef Kehrein and Rafael Worschech and Paria Pouyan and Rainer Haag and Ulrich S. Schubert and Thomas D. Müller and Lorenz Meinel and Tessa Lühmann}, doi = {10.1002/anie.202415354}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202415354}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering polymer interactions in bioconjugates with different architectures by structural analysis via time-resolved limited proteolysis mass spectrometry}, volume = {64}, year = {2025}, }
• (2025). Autocatalytic nucleation and self-assembly of inorganic nanoparticles into complex biosimilar networks. ANGEW, 64(9), e202413444. (www)

  @article{ , abstract = {Self-replication of bioorganic molecules and oil microdroplets have been explored as models in prebiotic chemistry. An analogous process for inorganic nanomaterials would involve the autocatalytic nucleation of metal, semiconductor, or ceramic nanoparticles-an area that remains largely uncharted. Demonstrating such systems would be both fundamentally intriguing and practically relevant, especially if the resulting particles self-assemble into complex structures beyond the capabilities of molecules or droplets. Here, we show that autocatalytic nucleation occurs with silver nanoparticles, which subsequently self-assemble into chains through spatially restricted attachment. In dispersions containing “hedgehog” particles, these reactions produce complex colloids with hierarchical spike organization. On solid surfaces, autocatalytic nucleation of nanoparticles yields conformal networks with hierarchical organization, including nanoparticle “colonies.” We analyzed the complexity of both types of solid-stabilized particle assemblies via graph theory (GT). The complexity index of idealized spiky colloids is comparable to that of complex algal skeletons. The GT analysis of the percolating nanoparticle networks revealed their similarities to the bacterial, but not fungal, biofilms. We conclude that coupling autocatalytic nucleation with self-assembly enables the generation of complex, biosimilar particles and films. This work establishes mathematical and structural parallels between biotic and abiotic matter, integrating self-organization, autocatalytic nucleation, and theoretical description of complex systems. Utilization of quantitative descriptors of connectivity patterns opens possibility to GT-based biomimetic engineering of conductive coatings and other complex nanostructures.}, archive = {J_ANGEW}, author = {Connor N. McGlothin and Kody G. Whisnant and Emine Sumeyra Turali Emre and Dickson Owuor and Jun Lu and Xiongye Xiao and Drew Vecchio and Scott Van Epps and Paul Bogdan and Nicholas Kotov}, doi = {10.1002/anie.202413444}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202413444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Autocatalytic nucleation and self-assembly of inorganic nanoparticles into complex biosimilar networks}, volume = {64}, year = {2025}, }
• (2025). Lanthanide-controlled protein switches: Development and in vitro and in vivo applications. ANGEW, 64(9), e202411584. (www)

  @article{ , abstract = {Lanthanides, which are part of the rare earth elements group have numerous applications in electronics, medicine and energy storage. However, our ability to extract them is not meeting the rapidly increasing demand. The discovery of the bacterial periplasmic lanthanide-binding protein lanmodulin spurred significant interest in developing biotechnological routes for lanthanide detection and extraction. Here we report the construction of β-lactamase-lanmodulin chimeras that function as lanthanide-controlled enzymatic switches. Optimized switches demonstrated dynamic ranges approaching 3000-fold and could accurately quantify lanthanide ions in simple colorimetric or electrochemical assays. E.coli cells expressing such chimeras grow on β-lactam antibiotics only in the presence of lanthanide ions. The developed lanthanide-controlled protein switches represent a novel platform for engineering metal-binding proteins for biosensing and microbial engineering.}, archive = {J_ANGEW}, author = {Zhong Guo and Oleh Smutok and Chantal Ronacher and Raquel Aguiar Rocha and Patricia Walden and Sergey Mureev and Zhenling Cui and Evgeny Katz and Colin Scott and Kirill Alexandrov}, doi = {10.1002/anie.202411584}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202411584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lanthanide-controlled protein switches: Development and in vitro and in vivo applications}, volume = {64}, year = {2025}, }
• (2025). Multiple structural and phase transformations of MOF and selective hydrocarbon gas separation in its amorphous, glass phase states. ANGEW, 64(9), e202411150. (www)

  @article{ , abstract = {The first wide-view image of multiple structural and phase transformations for MOFs, ranging from crystal state transformations to the extreme limit approaching liquid/glass phase, was presented. The process involves i) an initial crystalline transformation from square- layer framework [Co 2 (pybz) 2 (CH 3 COO) 2 ] ⋅ DMF ( Co2 ) to a 3-fold interpenetrated and ordered vacancies contained framework [Co(pybz) 2 (CH 3 OH) 2 ] ⋅ 2CH 3 OH ( CoM ) due to in situ disassemble-reassemble, ii) thermal induced departure of a pair of cis -form coordinated methanol in CoM leads to amorphous framework a -dCoM , iii) glass transition to super-cooled liquid scl -dCoM , iv) obtaining MOF glass g -dCoM upon quenching the super-cooled liquid, and v) re-crystallization of super-cooled liquid generates 6-fold interpenetrated dia - net framework [Co(pybz) 2 ] 6n ( rec -dCoM ) under further heating. The access to glass from CoM , provides a new self-perturbation strategy to create MOF glasses without melting. The wider pore size distribution in amorphous/glassy MOFs than crystalline precursor achieved the first time selective hydrocarbon gas separation by breakthrough experiments, which bring efficient separation of 1 : 99 C 2 H 2 /C 2 H 4 by either a -dCoM or g -dCoM and produce polymer grade C 2 H 4 with purity≥99.5 % after a single adsorption process. Furthermore, the mixture of 50 : 50 C 3 H 6 /C 3 H 8 can be separated by a -dCoM .}, archive = {J_ANGEW}, author = {Jian Li and Jia-Xin Wu and Tao Liu and Jian Yang and Mei-Ling Wei and Chuang Yang and Qiubing Dong and Zheng Yin and Mohamedally Kurmoo and Ming-Hua Zeng}, doi = {10.1002/anie.202411150}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202411150}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple structural and phase transformations of MOF and selective hydrocarbon gas separation in its amorphous, glass phase states}, volume = {64}, year = {2025}, }
• (2025). Anion-π interactions on functionalized porous aromatic cages for gold recovery from complex aqueous with high capacity. ANGEW, 64(9), e202410665. (www)

  @article{ , abstract = {High capacity, selective recovery and separation of precious metals from complex aqueous solutions is essential but remains a challenge in practical applications. Here, we prepared a thiophene-modified aromatic porous organic cage (T-PAC) with high stability for precise recognition and recovery of gold. T-PAC exhibits an outstanding gold uptake capacity of up to 2260 mg/g with fast adsorption kinetics and high adsorption selectivity. It's also used to selectively recover gold from a variety of complex aqueous solutions in a stable and efficient manner. The theoretical calculations and dedicated experiments suggest that anion-π interactions between the [AuCl 4 ] − and TFP fractions on T-PAC cooperated with S/N boning and redox effects play the decisive role in the highly efficient gold recovery performance.}, archive = {J_ANGEW}, author = {Jianzhu Jiang and Junning Kou and Qi Wu and Li Chen and Yun Geng and Guogang Shan and Chunyi Sun and Zhongmin Su and Xinlong Wang}, doi = {10.1002/anie.202410665}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {9}, pages = {e202410665}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion-π interactions on functionalized porous aromatic cages for gold recovery from complex aqueous with high capacity}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Chemical synthesis of ~1 nm multilevel capacitor-like particles with atomic precision. ANGEW, 64(8), e202580862. (www)

  @article{ , archive = {J_ANGEW}, author = {Yue Zhou and Dong Chen and Wanmiao Gu and Wentao Fan and Runguo Wang and Liang Fang and Qing You and Shengli Zhuang and Guoqing Bian and Lingwen Liao and Ziyan Zhou and Nan Xia and Jun Yang and Zhikun Wu}, doi = {10.1002/anie.202580862}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202580862}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Chemical synthesis of ~1 nm multilevel capacitor-like particles with atomic precision}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Divergent activity shifts of tin-based catalysts for electrochemical CO2 reduction: PH-dependent behavior of single-atom versus polyatomic structures. ANGEW, 64(8), e202580861. (www)

  @article{ , archive = {J_ANGEW}, author = {Yuhang Wang and Di Zhang and Bin Sun and Xue Jia and Linda Zhang and Hefeng Cheng and Jun Fan and Hao Li}, doi = {10.1002/anie.202580861}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202580861}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Divergent activity shifts of tin-based catalysts for electrochemical CO2 reduction: PH-dependent behavior of single-atom versus polyatomic structures}, volume = {64}, year = {2025}, }
• (2025). Back cover: Air-mediated biomimetic synthesis of polyhydroxyalkanoate with c4 diol (Angew. chem. int. ed. 8/2025). ANGEW, 64(8), e202502402. (www)

  @article{ , archive = {J_ANGEW}, author = {Huilin Xie and Kaibin Zhong and Shihao Niu and Xiaoxu Li and Zexu Hu and Guang Xiao and Yifu Huang and Hongjie Zhang and Yuan Liu and Hefeng Zhang and Qiuquan Cai}, doi = {10.1002/anie.202502402}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202502402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Air-mediated biomimetic synthesis of polyhydroxyalkanoate with c4 diol (Angew. chem. int. ed. 8/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Room-temperature magnetocapacitance spanning 97K hysteresis in molecular material (Angew. chem. int. ed. 8/2025). ANGEW, 64(8), e202500816. (www)

  @article{ , archive = {J_ANGEW}, author = {Ling-Ao Gui and Jiawei Chen and Yi-Fan Zhang and Long-He Li and Jian-Rong Li and Zhao-Bo Hu and Shi-Yong Zhang and Jinlei Zhang and Zhenyi Zhang and Heng-Yun Ye and Yan Peng and Jing Ma and You Song}, doi = {10.1002/anie.202500816}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202500816}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Room-temperature magnetocapacitance spanning 97K hysteresis in molecular material (Angew. chem. int. ed. 8/2025)}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Interdependence of support wettability - Electrodeposition rate- sodium metal anode and SEI microstructure (Angew. chem. int. ed. 8/2025). ANGEW, 64(8), e202500499. (www)

  @article{ , archive = {J_ANGEW}, author = {Chang-An Lo and Yixian Wang and Varun R. Kankanallu and Aditya Singla and Dean Yen and Xiaoyin Zheng and Kaustubh G. Naik and Bairav S. Vishnugopi and Callum Campbell and Vikalp Raj and Chonghang Zhao and Lu Ma and Jianming Bai and Feipeng Yang and Ruipeng Li and Mingyuan Ge and John Watt and Partha P. Mukherjee and David Mitlin and Yu-chen Karen Chen-Wiegart}, doi = {10.1002/anie.202500499}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202500499}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Interdependence of support wettability - Electrodeposition rate- sodium metal anode and SEI microstructure (Angew. chem. int. ed. 8/2025)}, volume = {64}, year = {2025}, }
• (2025). Stefano crespi. ANGEW, 64(8), e202500414. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202500414}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202500414}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stefano crespi}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Bienzymatic dynamic kinetic resolution of secondary alcohols by Esterification/Racemization in water (Angew. chem. int. ed. 8/2025). ANGEW, 64(8), e202424922. (www)

  @article{ , archive = {J_ANGEW}, author = {Aleksandra Rudzka and Tamara Reiter and Wolfgang Kroutil and Paweł Borowiecki}, doi = {10.1002/anie.202424922}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202424922}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Bienzymatic dynamic kinetic resolution of secondary alcohols by Esterification/Racemization in water (Angew. chem. int. ed. 8/2025)}, volume = {64}, year = {2025}, }
• (2025). Hybrid CIGS-cobalt quaterpyridine photocathode with backside illumination: A new paradigm for solar fuel production. ANGEW, 64(8), e202423727. (www)

  @article{ , abstract = {Chalcogenide-based thin-film solar cell optimized for rear illumination and used for CO 2 reduction is presented. Central to this innovation is a thinner, Cu(In,Ga)S 2 chalcopyrite absorber coated with a robust metallic top layer, which potentially surpasses the performance of conventional front-illuminated designs. Using cobalt quaterpyridine molecular catalyst, photocurrent densities for CO 2 reduction exceeding 10 mA/cm 2 at 0.0 V vs. RHE under 1 Sun illumination, and ca. 16 mA/cm 2 at −0.25 V vs. RHE were achieved in voltammetry experiments. Controlled potential electrolysis showed catalytic activity over 20 h with selectivity for CO ranging from >92 % (first 4 hours) to 86 % at the end of the experiment. This approach opens limitless possibilities for employing various reduction catalysts, extending far beyond CO 2 reduction. It imposes minimal constraints on absorption properties, immobilization methods, and catalyst nature, setting the stage for high-performance, adaptable PEC devices.}, archive = {J_ANGEW}, author = {Hichem Ichou and Léo Choubrac and Garen Suna and Debashrita Sarkar and Paulo Jorge Marques Cordeiro Junior and Stéphane Diring and Fabien Pineau and Julien Bonin and Nicolas Barreau and Marc Robert and Fabrice Odobel}, doi = {10.1002/anie.202423727}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202423727}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hybrid CIGS-cobalt quaterpyridine photocathode with backside illumination: A new paradigm for solar fuel production}, volume = {64}, year = {2025}, }
• (2025). Reprocessable and recyclable materials for 3D printing via reversible thia-michael reactions. ANGEW, 64(8), e202423522. (www)

  @article{ , abstract = {The development of chemically recyclable polymers for sustainable 3D printing is crucial to reducing plastic waste and advancing towards a circular polymer economy. Here, we introduce a new class of polythioenones (PCTE) synthesized via Michael addition-elimination ring-opening polymerization (MAEROP) of cyclic thioenone (CTE) monomers. The designed monomers are straightforward to synthesize, scalable and highly modular, and the resulting polymers display mechanical performance superior to commodity polyolefins such as polyethylene and polypropylene. The material was successfully employed in 3D printing using fused-filament fabrication (FFF), showcasing excellent printability and mechanical recyclability. Notably, PCTE−Ph retains its tensile strength and thermal stability after multiple mechanical recycling cycles. Furthermore, PCTE−Ph can be depolymerized back to its original monomer with a 90 % yield, allowing for repolymerization and establishing a successful closed-loop life cycle, making it a sustainable alternative for additive manufacturing applications.}, archive = {J_ANGEW}, author = {Yong-Liang Su and Liang Yue and McKinley K. Paul and Joseph Kern and Kaitlyn S. Otte and Rampi Ramprasad and H. Jerry Qi and Will R. Gutekunst}, doi = {10.1002/anie.202423522}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202423522}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reprocessable and recyclable materials for 3D printing via reversible thia-michael reactions}, volume = {64}, year = {2025}, }
• (2025). Building three-dimensional complexity by intramolecular 2-aminoallyl Cation−Diene (4+3) cycloaddition. ANGEW, 64(8), e202423405. (www)

  @article{ , abstract = {Reliable methods for rapidly constructing C(sp 3 )-rich three-dimensional polycycles are in high demand for organic synthesis and medicinal chemistry. Although there are various mature systems for synthesizing five- or six-membered polycycles, a catalytic platform for accessing diverse cycloheptanoid-containing polycyclic scaffolds is lacking. Herein, we describe a method for copper-catalyzed intramolecular 2-aminoallyl cation−diene (4+3) cycloaddition reactions. By using 1,3-diene-tethered ethynyl methylene cyclic carbamates as substrates, we were able to construct various cycloheptanoid-containing polycyclic scaffolds, which are present in many bioactive molecules. The cycloaddition products were rich in functionality that could undergo various chemical transformations. The synthetic utility of the method was illustrated by total synthesis of the natural products (±)-mint ketone and (±)-aphanamol I. Mechanistic studies indicated that the cycloadditions proceed by a concerted [4π+2π] mechanism and that an endo -selective pathway is favored.}, archive = {J_ANGEW}, author = {Lulu Shen and Tianzhu Qin and Chongling Jiao and Weiwei Zi}, doi = {10.1002/anie.202423405}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202423405}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Building three-dimensional complexity by intramolecular 2-aminoallyl Cation−Diene (4+3) cycloaddition}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-borrowing-based methods for the construction of quaternary stereocentres. ANGEW, 64(8), e202423179. (www)

  @article{ , abstract = {Compounds containing quaternary stereocentres are a valuable motif in biologically active compounds. Herein we present our strategy to utilise the hydrogen borrowing manifold to access α-quaternary ketones via a tandem acceptorless dehydrogenation-cyclisation cascade. This new application of the methodology results in the formation of five- and six-membered carbocycles with a high degree of diastereoselectivity. Interestingly, benzylic alcohol substrates behaved anomalously and eliminated sulfinate in situ to give a set of rearranged α-quaternary ketone products.}, archive = {J_ANGEW}, author = {Jessica L. Crompton and Timothy C. Jenkins and Sam M. Rowe and Timothy J. Donohoe}, doi = {10.1002/anie.202423179}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202423179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-borrowing-based methods for the construction of quaternary stereocentres}, volume = {64}, year = {2025}, }
• (2025). Leveraging iron in the electrolyte to improve oxygen evolution reaction performance: Fundamentals, strategies, and perspectives. ANGEW, 64(8), e202423071. (www)

  @article{ , abstract = {Electrochemical water splitting is a pivotal technology for storing intermittent electricity from renewable sources into hydrogen fuel. However, its overall energy efficiency is impeded by the sluggish oxygen evolution reaction (OER) at the anode. In the quest to design high-performance anode catalysts for driving the OER under non-acidic conditions, iron (Fe) has emerged as a crucial element. Although the profound impact of adventitious electrolyte Fe n+ species on OER catalysis had been reported forty years ago, recent interest in tailoring the electrode-electrolyte interface has spurred studies on the controlled introduction of Fe ions into the electrolyte to improve OER performance. During the catalytic process, scenarios where the rate of Fe n+ deposition on a specific host material outruns that of dissolution pave the way for establishing highly efficient and dynamically stable electrochemical interfaces for long-term steady operation. This review systematically summarizes recent endeavors devoted to elucidating the behaviors of in situ Fe (aq.) incorporation, the role of incorporated Fe sites in the OER, and critical factors influencing the interplay between the electrode surface and Fe ions in the electrolyte environment. Finally, unexplored issues related to comprehensively understanding and leveraging the dynamic exchange of Fe n+ at the interface for improved OER catalysis are summarized.}, archive = {J_ANGEW}, author = {Haiyan Li and Yuwei Zhang and Yubo Chen and Yang Li and Zhongjian Li and Bin Yang and Qinghua Zhang and Jianguo Lu and Lecheng Lei and Zhichuan J. Xu and Yang Hou}, doi = {10.1002/anie.202423071}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202423071}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging iron in the electrolyte to improve oxygen evolution reaction performance: Fundamentals, strategies, and perspectives}, volume = {64}, year = {2025}, }
• (2025). Unprecedented deep ultraviolet (DUV) birefringence in fluorides constructed from linear π-group anisotropic structure building units. ANGEW, 64(8), e202423054. (www)

  @article{ , abstract = {Advancing laser technologies requires maximizing the anisotropy of crystalline media and overcoming current birefringence limitations. We introduce the strategy of linear π group anisotropic structure building units (ABUCB), leading to an unprecedented large birefringence (Δ n ), a record-high Δ n obv. of 0.152 in sodium bis(dicyanoborato)fluoride (Na[BF 2 (CN) 2 ]), the highest reported among deep ultraviolet (DUV) materials. This value is 35 % greater than state-of-the-art α -BBO and 1167 % greater than MgF 2 . Density functional theory analyses suggest that the linear π group enhances bulk optical anisotropy and ensures a shorter DUV absorption edge. These results establish Na[BF 2 (CN) 2 ] as a groundbreaking DUV birefringent material and open new avenues for research into extending π groups and exploring additional possibilities.}, archive = {J_ANGEW}, author = {Meng-Yue Li and Xin Liu and Yi-Chen Liu and Rui-Xi Wang and Jingyu Guo and Li-Ming Wu and Ling Chen}, doi = {10.1002/anie.202423054}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202423054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unprecedented deep ultraviolet (DUV) birefringence in fluorides constructed from linear π-group anisotropic structure building units}, volume = {64}, year = {2025}, }
• (2025). DNA mimic foldamer recognition of a chromosomal protein. ANGEW, 64(8), e202422958. (www)

  @article{ , abstract = {Helical aromatic oligoamide foldamers bearing anionic side chains that mimic the overall shape and charge surface distribution of DNA were synthesized. Their interactions with chromosomal protein Sac7d, a non-sequence-selective DNA-binder that kinks DNA, were investigated by Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), Circular Dichroism spectroscopy (CD), melting curve analysis, Atomic Force Microscopy (AFM), and Nuclear Magnetic Resonance (NMR), as well as by single crystal X-ray crystallography. The foldamers were shown to bind to Sac7d better than a DNA duplex of comparable length. The interaction is diastereoselective and takes place at the DNA binding site. Crystallography revealed that the DNA mimic foldamers have a binding mode of their own and that they can bind to Sac7d without being kinked.}, archive = {J_ANGEW}, author = {Deepak Deepak and Jiaojiao Wu and Valentina Corvaglia and Lars Allmendinger and Michael Scheckenbach and Philip Tinnefeld and Ivan Huc}, doi = {10.1002/anie.202422958}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422958}, shortjournal = {Angew. Chem. Int. Edit.}, title = {DNA mimic foldamer recognition of a chromosomal protein}, volume = {64}, year = {2025}, }
• (2025). A highly biocompatible polyoxotungstate with fenton-like reaction activity for potent chemodynamic therapy of tumors. ANGEW, 64(8), e202422949. (www)

  @article{ , abstract = {Integrating Fenton chemistry and nanomedicine into cancer therapy has significantly promoted the development of chemodynamic therapy (CDT). Nanoscale polyoxometalates (POMs), with their reversible redox properties, exhibit promising potential in developing outstanding CDT drugs by exploring their Fenton-like catalytic reactivity in tumor environments. However, such research is still in its infancy due to the challenges of acquiring POMs that are both easily prepared and possess ideal therapeutic effects, physiological solubility, biocompatibility and safety. In this work, we report the synthesis of a new crystalline antimonotungstate {Dy 2 Sb 2 W 7 O 23 (OH)(DMF) 2 (SbW 9 O 33 ) 2 } ( 1 , DMF=N, N-dimethylformamide) with gram-scale high yield via a facile “one-pot” solvothermal reaction. 1 exhibits not only a soluble and water-stable POM nanocluster, but also excellent catalytic activity for hydroxyl radical-generating Fenton-like reactions. Further biomedical studies reveal that 1 can trigger cell apoptosis and promote lipid peroxidation, exhibiting high cytotoxicity and selectivity towards B16-F10 mouse melanoma cancer cells with an IC 50 value of 4.75 μM. Especially, 1 can inhibit melanoma growth in vivo with favorable biosafety, achieving a 5.2-fold reduction in tumor volume and a weight loss of 76.0 % at the dose of 70 μg/kg. This research not only demonstrates the immense potential of antimonotungstates in CDT drug development for the first time but also provides new insights and directions for the development of novel anticancer drugs.}, archive = {J_ANGEW}, author = {Hui-Ping Xiao and Man-Yi Du and Xian-Bin Sun and Ruo-Fei Xu and Dong-Miao Li and Sheng-Nan Yue and Ping-Wei Cai and Rong-Zhi Sun and Zi-Zhong Zhang and Xing Huang and Xin-Xiong Li and Yu Gao and Shou-Tian Zheng}, doi = {10.1002/anie.202422949}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly biocompatible polyoxotungstate with fenton-like reaction activity for potent chemodynamic therapy of tumors}, volume = {64}, year = {2025}, }
• (2025). Synthesis of γ-amino amides by iridium-catalyzed enantioselective hydroamination of internal alkenes directed by an amide. ANGEW, 64(8), e202422944. (www)

  @article{ , abstract = {Catalytic regio- and enantioselective hydroamination of less activated internal alkenes presents a challenge to synthetic chemists due to their low reactivity and the difficulty in simultaneously controlling regio- and enantioselectivities. Here, we report an iridium-catalyzed enantioselective hydroamination of internal alkenes directed by an amide. The amide group on the alkene effectively directs the catalyst to overcome the low reactivity and control the regioselectivity and the enantiotopic face selection. Phthalimide serves as the amination agent, which could be readily removed to afford a primary amine. This coordination assistance enables hydroamination to occur selectively at the remote position with up to 97 % ee, delivering valuable enantio-enriched γ-amino acid derivatives that are otherwise challenging to access.}, archive = {J_ANGEW}, author = {Yu-Wen Sun and Xin Sun and Hao-Tian Tan and Bi-Jie Li}, doi = {10.1002/anie.202422944}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422944}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of γ-amino amides by iridium-catalyzed enantioselective hydroamination of internal alkenes directed by an amide}, volume = {64}, year = {2025}, }
• (2025). Photo-driven ammonia synthesis via a proton-mediated photoelectrochemical device. ANGEW, 64(8), e202422869. (www)

  @article{ , abstract = {N 2 reduction reaction (NRR) by light is an energy-saving and sustainable ammonia (NH 3 ) synthesis technology. However, it faces significant challenges, including high energy barriers of N 2 activation and unclear catalytic active sites. Herein, we propose a strategy of photo-driven ammonia synthesis via a proton-mediated photoelectrochemical device. We used redox-catalysis covalent organic framework (COF), with a redox site (−C=O) for H + reversible storage and a catalytic site (porphyrin Au) for NRR. In the proton-mediated photoelectrochemical device, the COF can successfully store e − and H + generated by hydrogen oxidation reaction, forming COF−H. Then, these stored e − and H + can be used for photo-driven NRR (108.97 umol g −1 ) under low proton concentration promoted by the H-bond network formed between −OH in COF−H and N 2 on Au, which enabled N 2 hydrogenation and NH 3 production, establishing basis for advancing artificial photosynthesis and enhancing ammonia synthesis technology.}, archive = {J_ANGEW}, author = {Wan Lin and Jiajie Chen and Xiang Zhang and Jing Lin and Fuwen Lin and ShenXia Huang and Yaobing Wang}, doi = {10.1002/anie.202422869}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-driven ammonia synthesis via a proton-mediated photoelectrochemical device}, volume = {64}, year = {2025}, }
• (2025). Artificial metalloenzymes with two catalytic cofactors for tandem abiotic transformations. ANGEW, 64(8), e202422783. (www)

  @article{ , abstract = {Artificial metalloenzymes (ArMs) enable the integration of abiotic cofactors within a native protein scaffold, allowing for non-natural catalytic activities. Previous ArMs, however, have primarily relied on single cofactor systems, limiting them to only one catalytic function. Here we present an approach to construct ArMs embedding two catalytic cofactors based on the biotin-streptavidin technology. By incorporating multiple catalytic cofactors into the four binding sites of streptavidin, we engineered programmable ArMs for tandem abiotic transformations including an enantioselective formal C−H hydroxylation and a photooxidation-Michael addition. This work thus outlines a promising strategy for the development of ArMs embedding multiple cofactors.}, archive = {J_ANGEW}, author = {Weijin Wang and Ryo Tachibana and Kailin Zhang and Kelvin Lau and Florence Pojer and Thomas R. Ward and Xile Hu}, doi = {10.1002/anie.202422783}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422783}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial metalloenzymes with two catalytic cofactors for tandem abiotic transformations}, volume = {64}, year = {2025}, }
• (2025). Isoreticular tolerance and phase selection in the synthesis of multi-module Metal–Organic frameworks for gas separation and electrocatalytic OER. ANGEW, 64(8), e202422635. (www)

  @article{ , abstract = {Although metal–organic frameworks are coordination-driven assemblies, the structural prediction and design using metal-ligand interactions can be unreliable due to other competing interactions. Leveraging non-coordination interactions to develop porous assemblies could enable new materials and applications. Here, we use a multi-module MOF system to explore important and pervasive impact of ligand-ligand interactions on metal-ligand as well as ligand-ligand co-assembly process. It is found that ligand-ligand interactions play critical roles on the scope or breakdown of isoreticular chemistry. With cooperative di- and tri-topic ligands, a family of Ni-MOFs has been synthesized in various structure types including partitioned MIL-88-acs ( pacs ), interrupted pacs (i- pacs ), and UMCM-1-muo. A new type of isoreticular chemistry on the muo platform is established between two drastically different chemical systems. The gas sorption and electrocatalytic studies were performed that reveal excellent performance such as high C 2 H 2 /CO 2 selectivity of 21.8 and high C 2 H 2 uptake capacity of 114.5 cm 3 /g at 298 K and 1 bar.}, archive = {J_ANGEW}, author = {Yuchen Xiao and Xianhui Bu and Pingyun Feng}, doi = {10.1002/anie.202422635}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422635}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Isoreticular tolerance and phase selection in the synthesis of multi-module Metal–Organic frameworks for gas separation and electrocatalytic OER}, volume = {64}, year = {2025}, }
• (2025). Click-and-release formation of urea bonds in living cells enabled by micelle nanoreactors. ANGEW, 64(8), e202422627. (www)

  @article{ , abstract = {The development of innovative strategies enabling chemical reactions in living systems is of great interest for exploring and manipulating biological processes. Herein, we present a pioneering approach based on both bioorthogonal and confined chemistry for intracellular drug synthesis. Exploiting a click-to-release reaction, we engineered nanoparticles capable of synthesizing drugs within cellular environments through bioorthogonal reactions with cyclooctynes. Proof of concept experiments showed that this new approach could be successfully applied to the synthesis of the FDA-approved Sorafenib within cancer cells. The integration of bioorthogonal and confined chemistry not only offers exciting prospects for advancing therapeutic strategies but also opens up new avenues for exploring non-natural reactions within living systems. This innovative approach represents a fundamental extension of the biorthogonal chemistry concept and holds great promise for pioneering developments in therapeutic applications.}, archive = {J_ANGEW}, author = {Léa Madegard and Melissa Girard and Estelle Blochouse and Benjamin Riss Yaw and Alberto Palazzolo and Mélanie Laquembe and Davide Audisio and Pauline Poinot and Sébastien Papot and Frédéric Taran}, doi = {10.1002/anie.202422627}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Click-and-release formation of urea bonds in living cells enabled by micelle nanoreactors}, volume = {64}, year = {2025}, }
• (2025). Highly selective construction of unique cyclic [4]Catenanes induced by multiple noncovalent interactions. ANGEW, 64(8), e202422444. (www)

  @article{ , abstract = {The synthesis of high-ordered mechanically interlocked supramolecular structures is an extremely challenging topic. Only two linear [4]catenanes have been reported so far and there is no defined strategy to obtain cyclic [4]catenane. Herein, two unprecedented cyclic [4]catenanes, 1 and 2 , were prepared in high yields. The syntheses rely on the strategic selection of naphthalenediimide (NDI) based Cp*Rh/Ir building blocks E1 / E2 ( Cp*=pentamethyl-cyclopentadienyl ) and nonlinear diimidazole ligand precursor L1 , exhibiting large conjugate plane, appropriate coordination angles, and freely rotating imidazole units, thereby enabling multiple π⋅⋅⋅π stacking interactions to maintain the supramolecular structures. The use of other Cp*Rh building blocks E3 , E4 or E5 featuring slightly shorter metal-to-metal distances than E1/E2 and different chemical properties led to the formation of a complex 3 and two metallamacrocycles 4 or 5 , respectively. The structures of these assemblies were confirmed by X-ray crystallographic analysis, ESI-TOF-MS and NMR spectroscopy. Complex 1 , exhibiting a broad-band absorption in the UV/Vis to NIR regions and a remarkable photothermal conversion was thereafter used to build the new 1 membrane. The solar power-induced water steam generation performance of 1 membrane was investigated, reaching a value of 2.37 kg ⋅ m −2 ⋅ h −1 , making it suitable for collection of fresh water via desalination and wastewater.}, archive = {J_ANGEW}, author = {Li-Long Dang and Jie Zheng and Dan Tian and Yin-Hang Chai and Tian-Tian Wu and Jian-Xin Yang and Peng Wang and Ying Zhao and Francisco Aznarez and Lu-Fang Ma}, doi = {10.1002/anie.202422444}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422444}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly selective construction of unique cyclic [4]Catenanes induced by multiple noncovalent interactions}, volume = {64}, year = {2025}, }
• (2025). The electrochemical iodination of electron-deficient arenes. ANGEW, 64(8), e202422442. (www)

  @article{ , abstract = {The iodination of electron-deficient arenes and heteroarenes is a long-standing problem in organic synthesis. Herein we describe the electrochemical iodination in nitromethane with Bu 4 NI as iodine source and supporting electrolyte under Lewis acid-free conditions in the presence of small amounts of chloride anions. The electrochemically generated reagent could be applied for the iodination of halogenated arenes, aromatic aldehydes, acids, esters, ketones, as well as nitroarenes to afford the products in good to excellent yields.}, archive = {J_ANGEW}, author = {Sara Torabi and Mahdi Jamshidi and Gerhard Hilt}, doi = {10.1002/anie.202422442}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422442}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The electrochemical iodination of electron-deficient arenes}, volume = {64}, year = {2025}, }
• (2025). Near-infrared light-triggered cascade nanosystems for spatiotemporally controlled gene-silencing and gas synergistic cancer therapy. ANGEW, 64(8), e202422375. (www)

  @article{ , abstract = {Despite the tremendous potential of DNAzymes in gene therapy, achieving gene regulation with spatiotemporal precision and satisfactory efficacy remains a key challenge. Herein, we developed a near-infrared light (NIR)-triggered cascade effect system that enables precise spatiotemporal gene silencing and gas-synergistic cancer therapy. This nanoplatform was constructed using an enzyme-activatable DNAzyme, a nitric oxide (NO) precursor, and upconversion nanoparticles (UCNPs). The UCNPs act as light converters, facilitating the precursor to produce NO under NIR light irradiation, while the generated NO not only participates directly in gas therapy but also induces the upregulation of cytoplasmic APE1 level, resulting in enhanced DNAzyme activation and spatially controlled gene silencing. By leveraging this mechanism, cascade effects mediated gas-gene synergistic therapy is achieved through the combination of NIR light-controlled NO release and APE1-activatable gene therapy. We demonstrated that this nanoplatform enables enhanced anti-tumor effects both in vitro and in vivo . This strategy represents a critical step forward in the quest for highly targeted and efficient cancer treatments.}, archive = {J_ANGEW}, author = {Yaru Cheng and Youming Feng and Jian Zhao and Lele Li and Haifeng Dong}, doi = {10.1002/anie.202422375}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202422375}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared light-triggered cascade nanosystems for spatiotemporally controlled gene-silencing and gas synergistic cancer therapy}, volume = {64}, year = {2025}, }
• (2025). An sp2 carbon-conjugated covalent organic framework for fusing lipid droplets and engineered macrophage therapy. ANGEW, 64(8), e202421416. (www)

  @article{ , abstract = {Engineered immune cell therapy has proven to be a transformative cancer treatment despite the challenges of its prohibitive costs and manufacturing complexity. In this study, we propose a concise “lipid droplet fusion” strategy for engineering macrophages. Because of the integration of hydrophobic alkyl chains and π-conjugated structures, the mildly synthesized sp 2 C-conjugated covalent organic framework (COF) UM-101 induced lipid droplet fusion and metabolic reprogramming of macrophages, thus promoting their antitumor classical activation. Intravenous injection of UM-101 –engineered macrophages effectively inhibited tumor progression. These results represent the first report of room-temperature synthesis of sp 2 C-conjugated COFs for engineered immune cell therapy, providing a new perspective for the development of therapeutic immune cells via organelle manipulation.}, archive = {J_ANGEW}, author = {Qun Guan and Le-Le Zhou and Zhiqing Yang and Beibei Xie and Yan-An Li and Ruibing Wang}, doi = {10.1002/anie.202421416}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202421416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An sp2 carbon-conjugated covalent organic framework for fusing lipid droplets and engineered macrophage therapy}, volume = {64}, year = {2025}, }
• (2025). Integrating enzymes with reticular frameworks to govern biocatalysis. ANGEW, 64(8), e202421192. (www)

  @article{ , abstract = {Integrating enzymes with reticular frameworks offers promising avenues for access to functionally tailorable biocatalysis. This Minireview explores recent advances in enzyme-reticular framework hybrid biocomposites, focusing on the utilization of porous reticular frameworks, including metal-organic frameworks, covalent-organic frameworks, and hydrogen-bonded organic frameworks, to regulate the reactivity of an enzyme encapsulated inside mainly by pore infiltration and in situ encapsulation strategies. We highlight how pore engineering and host-guest interfacial interactions within reticular frameworks create tailored microenvironments that substantially impact the mass transfer and enzyme conformation, leading to biocatalytic rate enhancement, or imparting enzymes with non-native biocatalytic functions, including substrate selectivity and new activity. Additionally, the feasibility of leveraging the photothermal effect of a framework to optimize the local reaction temperature and photoelectric effect to elicit diverse photoenzyme-coupled reactions is also summarized in detail, which can expand the functional repertoire of biocatalytic transformations under light irradiation. This Minireview underscores the potential of reticular frameworks as tunable and reliable platforms to govern biocatalysis, offering pathways for engineering sustainable, efficient, and selective biocatalytic reactors in pharmaceutical, environmental, and energy-related applications.}, archive = {J_ANGEW}, author = {Linjing Tong and Siming Huang and Guosheng Chen and Gangfeng Ouyang}, doi = {10.1002/anie.202421192}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202421192}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating enzymes with reticular frameworks to govern biocatalysis}, volume = {64}, year = {2025}, }
• (2025). Electrifying P(V): Access to polar and radical reactivity. ANGEW, 64(8), e202421163. (www)

  @article{ , abstract = {Electrochemical, fully stereoselective P(V)-radical hydrophosphorylation of olefins and carbonyl compounds using a P(V) reagent is disclosed. By strategically selecting the anode material, radical reactivity is accessible for alkene hydrophosphorylation whereas a polar pathway operates for ketone hydrophosphorylation. The mechanistic intricacies of these chemoselective transformations were explored in-depth.}, archive = {J_ANGEW}, author = {Mahdi Jafarzadeh and Molhm Nassir and Luca Gherardi and Nicholas Raheja and Yu Kawamata and Phil S. Baran}, doi = {10.1002/anie.202421163}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202421163}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrifying P(V): Access to polar and radical reactivity}, volume = {64}, year = {2025}, }
• (2025). Chemical synthesis of ~1 nm multilevel capacitor-like particles with atomic precision. ANGEW, 64(8), e202420931. (www)

  @article{ , abstract = {Can the chemically synthesized nanoparticles act as nanodevices or nanomachines? Herein, we demonstrated this feasibility. A novel nanocluster (ultrasmall nanoparticle) [Au 44 Cd 20 ( m -MBT) 40 ][N(C 8 H 17 ) 4 ] 2 (Au 44 Cd 20 in short, m -MBTH: m -methylbenzenethiol) obtained via developing a synthesis method has a cannula-like structure of the outer shell and an internal sleeve, revealed by single-crystal X-ray diffraction. Natural population analysis (NPA) charge calculations, charge carrier transport of Au 44 Cd 20 (during which an intra-nanocluster anti-galvanic reaction was observed) after unneutral charging using NaBH 4 as well as voltammetry proved the capacitor-like character of Au 44 Cd 20 . The subsidiary capacitor-like character of the outer shell of Au 44 Cd 20 was further probed via NPA charge calculations and electrocatalytic reduction of CO 2 to CO. Thus, this study predicts a new era of engineering metal nanoparticles for realizing atomically precise ultrasmall nanodevices and nanomachines.}, archive = {J_ANGEW}, author = {Yue Zhou and Dong Chen and Wanmiao Gu and Wentao Fan and Runguo Wang and Liang Fang and Qing You and Shengli Zhuang and Guoqing Bian and Lingwen Liao and Ziyan Zhou and Nan Xia and Jun Yang and Zhikun Wu}, doi = {10.1002/anie.202420931}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420931}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical synthesis of ~1 nm multilevel capacitor-like particles with atomic precision}, volume = {64}, year = {2025}, }
• (2025). Sprayed aqueous microdroplets for spontaneous synthesis of functional microgels. ANGEW, 64(8), e202420926. (www)

  @article{ , abstract = {The development of sustainable synthesis route to produce functional and bioactive polymer colloids has attracted much attention. Most strategies are based on the polymerization of monomers or crosslinking of prepolymers by enzyme- or cell-mediated reactions or specific catalysts in confined emulsions. Herein, a facile solution spray method was developed for spontaneous synthesis of microgels without use of confined emulsion, additional initiators/catalysts and deoxygenation, which addresses the challenges in traditional microgel synthesis. The polarization of air-water interface of the microdroplets can spontaneously split hydroxide ions in water to produce hydroxyl radicals, thereby initiating polymerization and crosslinking in air environment. This synthesis strategy is applicable to a variety of monomers and enables the fabrication of microgels with tunable chemical structures and variable sizes. Importantly, the synthesis route also allows for the preparation of enzyme- or drug-loaded microgels via the in situ encapsulation, which also display high enzymatic activity and stimuli-triggered drug release. Therefore, this work not only is of great significance to macromolecular science and microdroplet chemistry, but also may bring new insights into cellular biochemistry and even prebiotic chemistry due to the prevalence of microdroplets in the environment.}, archive = {J_ANGEW}, author = {Xin Li and Wenjing Zhang and Helin Li and Qi Shuai and Xingcai Zhang and Andrij Pich}, doi = {10.1002/anie.202420926}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420926}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sprayed aqueous microdroplets for spontaneous synthesis of functional microgels}, volume = {64}, year = {2025}, }
• (2025). A self-reinforced “Microglia energy modulator” for synergistic amyloid-β clearance in alzheimer's disease model. ANGEW, 64(8), e202420547. (www)

  @article{ , abstract = {Microglial phagocytosis is a highly energy-consuming process that plays critical roles in clearing neurotoxic amyloid-β (Aβ) in Alzheimer's disease (AD). However, microglial metabolism is defective overall in AD, thereby undermining microglial phagocytic functions. Herein, we repurpose the existing antineoplastic drug lonidamine (LND) conjugated with hollow mesoporous Prussian blue (HMPB) as a “microglial energy modulator” (termed LND@HMPB-T7) for safe and synergistic Aβ clearance. The modified blood–brain barrier penetrating heptapeptide (T7) enables efficient transport of LND@HMPB-T7 to the AD brain. LND in LND@HMPB-T7 could fuel Aβ phagocytosis by stimulating microglial adenosine triphosphate (ATP) production, whereas HMPB with catalase and superoxide dismutase-mimicking activities substantially alleviates the mitochondrial side effects commonly associated with LND and thus further enhances ATP production. The synergism of LND and nanozyme affords a high microglial Aβ clearance efficacy without triggering mitochondrial dysfunction. In vivo experiments ascertain that LND@HMPB-T7 could synergistically promote phagocytic clearance of Aβ, relieve neuroinflammation and ameliorate cognitive function in AD mice. These findings indicate that LND@HMPB-T7 holds tremendous clinical potential as a repurposed drug for AD treatment.}, archive = {J_ANGEW}, author = {Mengmeng Ma and Jing Wang and Kaiming Guo and Wenbin Zhong and Yu Cheng and Li Lin and Yanli Zhao}, doi = {10.1002/anie.202420547}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420547}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A self-reinforced “Microglia energy modulator” for synergistic amyloid-β clearance in alzheimer's disease model}, volume = {64}, year = {2025}, }
• (2025). Cooperation of multifunctional redox mediator and separator modification to enhance li-S batteries performance under low Electrolyte/Sulfur ratios. ANGEW, 64(8), e202420544. (www)

  @article{ , abstract = {Sluggish reaction kinetics of sulfur species fundamentally trigger the incomplete conversion of S 8 ↔Li 2 S and restricted lifespan of lithium-sulfur batteries, especially under high sulfur loading and/or low electrolyte/sulfur (E/S) ratios. Developing redox mediators (RMs) is an effective strategy to boost the battery reaction kinetics, yet their multifunctionality and shuttle inhibition are still not available. Here, a unique ethyl viologen (EtV 2+ ) RM with two highly reversible redox couples (EtV 2+ /EtV + , EtV + /EtV 0 ) is demonstrated to well match the redox chemistry of sulfur species, in terms of accelerating the electron transfer in S 8 reduction, Li 2 S nucleation and the Li 2 S oxidation. When coupling with a functionalized separator with electronegative -SO 3 Li groups, a synergetic chemistry is established to ensure the substantial inhibition of the shuttle effect and the acceleration of charge transfer. As a result, the activation energies during sulfur species conversion (S 8 →Li 2 S 4 →Li 2 S/Li 2 S 2 →Li 2 S 4 →S 8 ) are decreased, especially for Li 2 S nucleation step. The correspond lithium-sulfur batteries achieve a high specific capacity of 1006.9 mAh g− 1 (0.1 C; sulfur loading of 5 mg cm −2 ; E/S ratios of 6 μL mg s −1 ), and an outstanding cycling stability. This study provides a paradigm of solving complex problems via multifunctional molecule engineering and strategic cooperation towards Li−S batteries and other battery communities.}, archive = {J_ANGEW}, author = {Weihua Jin and Yunpeng Guo and Taorong Gan and Zhengyuan Shen and Xuebing Zhu and Peng Zhang and Yong Zhao}, doi = {10.1002/anie.202420544}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420544}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperation of multifunctional redox mediator and separator modification to enhance li-S batteries performance under low Electrolyte/Sulfur ratios}, volume = {64}, year = {2025}, }
• (2025). Fluoromethyl triflate and fluoromethyl fluorosulfonate: Easily accessible and powerful fluoromethylation reagents. ANGEW, 64(8), e202420540. (www)

  @article{ , abstract = {Fluoromethyl triflate (superfluoromethyl, SFM, FH 2 COSO 2 CF 3 ) and fluoromethyl fluorosulfonate (magic fluoromethyl, MFM, FH 2 COSO 2 F) are two easily synthesized, highly effective and non-ozone depleting fluoromethylation reagents. They are analogous to the well-known and widely used methylation reagents H 3 COSO 2 CF 3 and H 3 COSO 2 F. Both SFM and MFM have been fully characterized by multinuclear NMR spectroscopy ( 1 H, 13 C, 17 O, 19 F, 33 S). Their structures have been determined in the solid state on in situ grown crystals by X-ray diffraction and in the gas phase by electron diffraction. The fluoromethylation efficiency of SFM and MFM was shown by reactions with chalcogen nucleophiles of differing nucleophilicity. All fluoromethylated products were isolated as pure compounds and characterized by NMR and vibrational spectroscopy, as well as in some cases by single crystal X-ray diffraction.}, archive = {J_ANGEW}, author = {Alexander Gisnapp and Pia C. Trapp and Jan Schwabedissen and Hans-Georg Stammler and Marco Reichel and Dominik Leitz and Burkhard Krumm and Konstantin Karaghiosoff and Norbert W. Mitzel}, doi = {10.1002/anie.202420540}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420540}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluoromethyl triflate and fluoromethyl fluorosulfonate: Easily accessible and powerful fluoromethylation reagents}, volume = {64}, year = {2025}, }
• (2025). P-dopant with spherical anion for stable n-i-p perovskite solar cells. ANGEW, 64(8), e202420535. (www)

  @article{ , abstract = {Li-TFSI/ t -BP is the most widely utilized p-dopant for hole-transporting materials (HTMs) in state-of-the-art perovskite solar cells (PSCs). However, its nonuniformity of doping, along with the hygroscopicity and migration of dopants, results in the devices exhibiting limited stability and performance. This study reports on the utilization of a spherical anion derived from the p-dopant, regulated by its radius and shape, as an alternative to the linear TFSI − anion. The theoretical and experimental results reveal that the spherical anion significantly increases the doping effect of HTMs due to an enhanced electron transfer from larger dipole moments. The enhanced transfer leads to a shift in the Pb-6p defect orbitals, resulting in shallower trap states. Moreover, compared to the linear structure of the TFSI − anion, the anion of sodium tetrakis[3,5-bis(trifluoro methyl)phenyl]borate (Na-TFPB) with a larger van der Waals radius and spherical shape offers increased hydrophobicity and migration barriers, which can protect the perovskite crystal and facilitate stable p-doping of HTMs. The use of Na-TFPB results in enhanced thermal and ambient stability of PSCs. The devices fabricated with the shape- and radius-regulated p-dopant achieve remarkable efficiencies of 24.49 % and 24.31 % for CJ-01 and spiro-OMeTAD, respectively, representing the highest efficiency values for organic dopants to date. This study underscores the ingenious design of spherical anions of p-dopants in contrast to the conventional linear anions.}, archive = {J_ANGEW}, author = {Guang Shao and Zu-Kun Zhou and Dian Wang and Jing Xiao and Shang-Gen Yang and Hui-Juan Yu and Jun-Feng Qu and Zhi-Zheng Wu and Jun-Jie Zhang and Lifen Peng and Qurat Ul Ain and Ammar Ahmed Khan and Yu Chen and Hua Yang and Zeliang Qiu and Ruiyuan Hu and Xingao Li and Khalid A. Alamry and Jianxing Xia and Yi Zhang and Mohammad Khaja Nazeeruddin}, doi = {10.1002/anie.202420535}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420535}, shortjournal = {Angew. Chem. Int. Edit.}, title = {P-dopant with spherical anion for stable n-i-p perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Tyrosinase-catalyzed peptide stapling using para-amino phenylalanine and tyrosine anchoring residues. ANGEW, 64(8), e202420522. (www)

  @article{ , abstract = {Peptide stapling techniques have historically relied on metal-catalyzed chemical reactions, with no examples using enzymes. Here, inspired by tyrosinase-mediated oxidation, we describe the efficient side-chain to side-chain coupling of p -amino phenylalanine (Z) and tyrosine (Y) amino acids using a commercially available tyrosinase. Stapling reactions between the i , i+3 to i , i+7 positions were all performed, proceeding in good conversion and under mild conditions compatible with various side chains, functional motifs and ring sizes, with the Z−Y product found to be more stable and obtained in a higher yield than the Y−Z product. Z−Y stapled versions of ER, MC4 and GPR54 binding peptides exhibited higher serum stability, helical content and binding affinity than their linear counterparts, proving the utility of our method to synthesize biologically significant peptides. The tyrosinase-catalyzed Z−Y peptide stapling technique expands the scope of available stapling techniques, and is proposed to develop stapled peptide drug candidates.}, archive = {J_ANGEW}, author = {Nan Wang and Zhengyang Xu and Huaxing Shen and Wei Cong and Shuai Zhang and Honggang Hu and Xiang Li}, doi = {10.1002/anie.202420522}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420522}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tyrosinase-catalyzed peptide stapling using para-amino phenylalanine and tyrosine anchoring residues}, volume = {64}, year = {2025}, }
• (2025). Thiosulfate-mediated polysulfide redox for energetic aqueous battery. ANGEW, 64(8), e202420514. (www)

  @article{ , abstract = {Sulfur-based aqueous batteries (SABs) are regarded as promising candidates for safe, low-cost, and high-energy storage. However, the sluggish redox kinetics of polysulfides pose a significant challenge to the practical performance of SABs. Herein, we report a unique redox regulation strategy that leverages thiosulfate-mediated ligand-chain interaction to accelerate the polysulfide redox process (S 0 /S 2− ). The S 2 O 3 2− species in the electrolyte can induce the rapid reduction of polysulfide through a spontaneous chemical reaction with sulfur species, while facilitating the reversible oxidation of short-chain sulfides. Moreover, the thiosulfate redox pair (S 2 O 3 2− /S 4 O 6 2− ) within the K 2 S 2 O 3 electrolyte contributes additional capacity at higher potential (E 0 >0 V vs SHE). Consequently, the elaborate SAB delivers an unprecedented K + storage capacity of 2470 mAh g s −1 , coupled with a long cycling life exceeding 1000 cycles. Remarkably, thiosulfate-mediated SAB achieves an energy density of 616 Wh kg S+Zn −1 , surpassing both organic K–S batteries and conventional aqueous battery systems. This work elucidates the mechanism underlying the thiosulfate-mediated polysulfide redox process, thereby opening a pathway for the development of high-energy aqueous batteries.}, archive = {J_ANGEW}, author = {Yutong Feng and Xiaoyu Yu and Boya Wang and Tengsheng Zhang and Wanhai Zhou and Yifeng Wang and Xinran Li and Jian Zhao and Jingwen Zhao and Wei Li and Chenyan Ma and Dongyuan Zhao and Dongliang Chao}, doi = {10.1002/anie.202420514}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420514}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thiosulfate-mediated polysulfide redox for energetic aqueous battery}, volume = {64}, year = {2025}, }
• (2025). Unlocking cage-confined cations molecular dynamics toward high-tc perovskite ferroelectrics. ANGEW, 64(8), e202420512. (www)

  @article{ , abstract = {Cage-confinement effect that imposes great constriction on the dynamic behaviors of guest molecules is an established platform for tailoring physical properties. Herein, the strategy of enhancing cage-confinement effect to control molecular motion has been probed for the first time to exploit new high- T c ferroelectrics of 2D hybrid perovskites. By fine-tailoring of the confined cations inside the perovskite cavities, we have successfully obtained new homologous ferroelectrics of (BA) 2 (MA) 2 Pb 3 Cl 10 ( 1 ; BA = n -butylamine, MA=methylamine) and (BA) 2 (EA) 2 Pb 3 Cl 10 ( 2 ; EA=ethylamine). Intriguingly, this dynamics modulation of cage-confined cations leads to a remarkable promotion of Curie temperature ( T c ), boosting from 340 K (for 1 ) to 402 K (for 2 ). In situ solid-state NMR spectroscopy and theoretical simulations on energy barrier confirm that the larger EA cation in 2 is subject to stronger confinement effect, of which potential energy barrier of molecular motion is ~3.5 times that of MA cation. This dynamic behavior greatly suppresses the dynamic motions of EA cation, while MA cation can easily accelerate motion and reach a fast motion limit, thus accounting for an enhancement of T c (ΔT~62 K) in 2 . The finding sheds light on the understanding of cage-confined electric orders and the precise design of high-performance ferroelectrics.}, archive = {J_ANGEW}, author = {Yu Ma and Wenjing Li and Jianchao Sun and Yi Liu and Wuqian Guo and Hao Rong and Qiaohong Li and Xiaobin Fu and Junhua Luo and Zhihua Sun}, doi = {10.1002/anie.202420512}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420512}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking cage-confined cations molecular dynamics toward high-tc perovskite ferroelectrics}, volume = {64}, year = {2025}, }
• (2025). Cascade selenization regulated the electronic structure and interface effect of transition metal sulfides for enhanced sodium storage. ANGEW, 64(8), e202420504. (www)

  @article{ , abstract = {The utilization of cobalt-based sulfides is constrained by their inherently low conductivity and slow sodium ion diffusion kinetics. Modifying the electronic configuration and constructing heterostructures are promising strategies to enhance intrinsic conductivity and expedite the sodium ion diffusion process. In this study, heterogeneous nanoparticles of Se-substituted CoS 2 /CoSe 2 , embedded within heteroatom-modified carbon nanosheet, were synthesized using metal molten salt-assisted dimensionality reduction alongside concurrent sulfurization and selenization techniques. The incorporation of Se into CoS 2 markedly enhances its intrinsic conductivity, thereby significantly improving its rate performance. The elongated Co−S bonds and the formation of CoSe 2 species contribute to the acceleration of dynamics and facilitate the construction of the CoS 2 /CoSe 2 heterointerface. In situ Raman spectroscopy, in conjunction with theoretical calculations, has elucidated the sodium storage mechanism of the Se−CoS 2 /CoSe 2 and the underlying factors contributing to its enhanced performance. The synergistic effects of interface engineering and electronic structure engineering, have resulted in the optimized Se−CoS 2 /CoSe 2 demonstrating exceptional rate performance, achieving 442 mAh g −1 at 10 A g −1 , and a prolonged cycle lifespan, maintaining 409.3 mAh g −1 at 5 A g −1 over 2100 cycles and 262.5 mAh g −1 after 7000 cycles at 10 A g −1 . This study presents a viable strategy for integrating electronic structure engineering with interface engineering.}, archive = {J_ANGEW}, author = {Ting Feng and Fang Wang and Zixu Sun and Fangya Guo and Yi Xiong and Fengzhang Ren and Chunjuan Tang and Jili Li and Hua Kun Liu and Shi Xue Dou}, doi = {10.1002/anie.202420504}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420504}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cascade selenization regulated the electronic structure and interface effect of transition metal sulfides for enhanced sodium storage}, volume = {64}, year = {2025}, }
• (2025). Pressure-engineered through-space conjugation for precise control of clusteroluminescence. ANGEW, 64(8), e202420502. (www)

  @article{ , abstract = {Clusteroluminogens (CLgens) represent an innovative class of nonconjugated luminophores that address the limitations of conventional π-conjugated molecules. Different from the through-bond conjugation mechanism in π-conjugated luminophores, through-space conjugation (TSC) plays dominant roles in CLgens. However, precisely controlling TSC to customize the optical properties of CLgens remains a significant challenge. This work proposes a novel strategy of high pressure to engineer TSC within tetraphenylalkanes (TPAs)-based CLgens at molecular level. High-pressure exploration enables accurate manipulation of clusteroluminescence and elucidates the intrinsic structure–property relationships involved. Upon initial compression, the predominant molecular distortions marked by increased interfacial angles between benzene rings diminish TSC, resulting in anomalous hypochromatic shift in emission. Subsequently, considerable structural contraction enhances TSC and suppresses molecular motion, resulting in a pronouncedly enhanced and bathochromic-shifted emission. Notably, a series of TPAs-based CLgens exhibit intense white-light emission upon pressure release, attributed to irreversible structural distortion and destruction. This study not only advances the understanding of CLgens, but also underscores the crucial structural factors for effective TSC control, paving the way for establishing new photophysical theories for aggregate science.}, archive = {J_ANGEW}, author = {Yayun Wang and Zuping Xiong and Yanan Wang and Aisen Li and Yuanyuan Fang and Lei Li and Kai Wang and Qian Li and Haoke Zhang}, doi = {10.1002/anie.202420502}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pressure-engineered through-space conjugation for precise control of clusteroluminescence}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic hydroxylation and oxidative coupling reactions mediated by multinuclear Au(I) supramolecular clusters. ANGEW, 64(8), e202420499. (www)

  @article{ , abstract = {Polynuclear Au(I) cluster photocatalysts, known for their high activity and stability, hold substantial potential in organic synthetic chemistry. This study synthesized two Au(I) supramolecular cluster catalysts with different nuclearities: a tetranuclear cluster, C1 ([(dppmAu 2 ) 2 L 1 ] • PF 6 − ), and a hexadecanuclear cluster, C2 [(dppmAu 2 ) 6 (Au 4 )( L 1 ) 4 ] • 4PF 6 − , through a multicomponent stepwise self-assembly approach. Both cluster structures feature aurophilicity interaction motifs that endow them with exceptional photocatalytic performance, exhibiting optical band gaps of 2.27 eV and 2.41 eV, respectively. Upon photoexcitation, these clusters efficiently generate reactive oxygen species, significantly enhancing their photocatalytic efficacy for the oxidative hydroxylation of phenylboronic acids and oxidative coupling of benzylamines under mild conditions. Catalytic efficiencies exceeding 90 % were achieved. Turnover frequencies for C2 and C1 were measured at 52.045 h −1 and 6.030 h −1 , respectively, representing the highest efficiencies reported for photocatalysts to date. Compared to C1 , C2 exhibited superior photocatalytic activity, attributed to its higher photoelectric sensitivity and greater exposure of active metal sites. Using a combination of experimental data and density functional theory calculations, the plausible mechanisms were proposed for two photocatalytic reactions. This study demonstrates that the use of multicomponent cooperative self-assembly strategy to synthesize high-nuclearity Au(I) clusters offers innovative pathways for the development of efficient, green, light-driven organic synthesis.}, archive = {J_ANGEW}, author = {Qing-Ya Sun and Hui-Zhen He and Ying Zhou and Yu-Peng Dai and Ping Shang and Xuan-Feng Jiang}, doi = {10.1002/anie.202420499}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420499}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic hydroxylation and oxidative coupling reactions mediated by multinuclear Au(I) supramolecular clusters}, volume = {64}, year = {2025}, }
• (2025). Anionic doping in layered transition metal chalcogenides for robust lithium-sulfur batteries. ANGEW, 64(8), e202420488. (www)

  @article{ , abstract = {Lithium-sulfur batteries (LSBs) are among the most promising next-generation energy storage technologies. However, a slow Li−S reaction kinetics at the LSB cathode limit their energy and power densities. To address these challenges, this study introduces an anionic-doped transition metal chalcogenide as an effective catalyst to accelerate the Li−S reaction. Specifically, a tellurium-doped, carbon-supported bismuth selenide with Se vacancies (Te−Bi 2 Se 3–x @C) is prepared and tested as a sulfur host in LSB cathodes. X-ray absorption and in situ X-ray diffraction analyses reveal that Te doping induces lattice distortions and modulates the local coordination environment and electronic structure of Bi atoms to promote the catalytic activity toward the conversion of polysulfides. Additionally, the generated Se vacancies alter the electronic structure around atomic defect sites, increase the carrier concentration, and activate unpaired cations to effectively trap polysulfides. As a result, LSBs based on Te−Bi 2 Se 3–x @C/S cathodes demonstrate outstanding specific capacities of 1508 mAh ⋅ g −1 at 0.1 C, excellent rate performance with 655 mAh ⋅ g −1 at 5 C, and near-integral cycle stability over 1000 cycles. Furthermore, under high sulfur loading of 6.4 mg ⋅ cm −2 , a cathode capacity exceeding 8 mAh ⋅ cm −2 is sustained at 0.1 C current rate, with 6.4 mAh ⋅ cm −2 retained after 300 cycles under lean electrolyte conditions (6.8 μL ⋅ mg −1 ).}, archive = {J_ANGEW}, author = {Chen Huang and Jing Yu and Chao Yue Zhang and Zhibiao Cui and Ren He and Linlin Yang and Bingfei Nan and Canhuang Li and Xuede Qi and Xueqiang Qi and Junshan Li and Jin Yuan Zhou and Oleg Usoltsev and Laura Simonelli and Jordi Arbiol and Yao-Jie Lei and Qing Sun and Guoxiu Wang and Andreu Cabot}, doi = {10.1002/anie.202420488}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anionic doping in layered transition metal chalcogenides for robust lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Accessing azetidines through magnesium-mediated nitrogen group transfer from iminoiodinane to donor-acceptor cyclopropanes. ANGEW, 64(8), e202420485. (www)

  @article{ , abstract = {Herein, we report a Lewis acid-mediated ring expansion of donor-acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane. This protocol operates under mild, transition-metal-free conditions, and showcases excellent chemoselectivity, along with broad functional group tolerance. We report for the first time that challenging alkyl donor-acceptor cyclopropanes can undergo ring expansion leading to aliphatic azetidines without relying on external oxidants or precious transition-metal catalysts. Mechanistically, the coordination of a magnesium (Mg)-Lewis acid to the DAC promotes nucleophilic ring opening with a putative Mg-amide species generated from the iminoiodinane under the reaction conditions to furnish the azetidine products.}, archive = {J_ANGEW}, author = {Ajay H. Bansode and Lifeng Yin and Ning Deng and Mahmoud Afrasi and Yiyi Zhu and Marvin Parasram}, doi = {10.1002/anie.202420485}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420485}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accessing azetidines through magnesium-mediated nitrogen group transfer from iminoiodinane to donor-acceptor cyclopropanes}, volume = {64}, year = {2025}, }
• (2025). Breaking the stability-activity trade-off of oxygen electrocatalyst by gallium bilateral-regulation for high-performance zinc-air batteries. ANGEW, 64(8), e202420481. (www)

  @article{ , abstract = {The rational design of metal oxide catalysts with enhanced oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) performance is crucial for the practical application of aqueous rechargeable zinc-air batteries (a-r-ZABs). Precisely regulating the electronic environment of metal-oxygen (M−O) active species is critical yet challenging for improving their activity and stability toward OER and ORR. Herein, we propose an atomic-level bilateral regulation strategy by introducing atomically dispersed Ga for continuously tuning the electronic environment of Ru−O and Mn−O in the Ga/MnRuO 2 catalyst. The Ga/MnRuO 2 catalyst breaks the stability-activity restriction, showing remarkable bifunctional performance with a low potential gap (ΔE) of 0.605 V and super durability with negligible performance degradation (300,000 ORR cycles or 30,000 OER cycles). The theoretical calculations revealed that the strong coupling electron interactions between Ga and Ru−O/Mn−O tuned the valence state distribution of the metal center, effectively modulating the adsorption behavior of *O/*OH, thus optimizing the reaction pathways and reducing the reaction barriers. The a-r-ZABs based on Ga/MnRuO 2 catalysts exhibited excellent performance with a wide working temperature range of −20–60 °C and a long lifetime of 2308 hours (i.e., 13,848 cycles) under a current density of 5 mA cm −2 at −20 °C.}, archive = {J_ANGEW}, author = {Yunrui Li and Jiaqi Xu and Fan Lan and Yao Wang and Hairong Jiang and Xueke Wu and Ya Huang and Run Li and Qinyuan Jiang and Di Gao and Ping Zhu and Siming Zhao and Yanlong Zhao and Fei Wang and Libo Zhang and Longgui Zhang and Rufan Zhang}, doi = {10.1002/anie.202420481}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420481}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Breaking the stability-activity trade-off of oxygen electrocatalyst by gallium bilateral-regulation for high-performance zinc-air batteries}, volume = {64}, year = {2025}, }
• (2025). Excited-state engineering of chalcogen-bridged chiral molecules for efficient OLEDs with diverse luminescence mechanisms. ANGEW, 64(8), e202420474. (www)

  @article{ , abstract = {The exploration of circularly polarized luminescence is important for advancing display and lighting technologies. Herein, by utilizing isomeric molecular engineering, a novel series of chiral molecules are designed to exploit both thermally activated delayed fluorescence (TADF) and room-temperature phosphorescence (RTP) mechanisms for efficient luminescence. The cooperation of a small singlet-triplet energy gap, moderate spin-orbital coupling (SOC), and large oscillator strength enables efficient TADF emission, with photoluminescence quantum yields exceeding 90 %. By altering the symmetry of molecular structures, it is demonstrated that the intrinsic electronic SOC and vibrational SOC effects can be greatly enhanced to facilitate RTP emission. Notably, through modulating simultaneous TADF and RTP emissions, single-molecule white emission is successfully achieved. Accordingly, the TADF-based organic light-emitting diode (OLED) achieves a maximum external quantum efficiency up to 30 %, representing exceptional performance of non-aromatic amine-based emitters. Furthermore, the first single-molecule white OLED based on TADF and RTP dual-emissive chiral material is developed, establishing a benchmark for the development of advanced display and lighting technologies.}, archive = {J_ANGEW}, author = {Mengke Li and Zhizhi Li and Xiaomei Peng and Denghui Liu and Zijian Chen and Wentao Xie and Kunkun Liu and Shi-Jian Su}, doi = {10.1002/anie.202420474}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420474}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Excited-state engineering of chalcogen-bridged chiral molecules for efficient OLEDs with diverse luminescence mechanisms}, volume = {64}, year = {2025}, }
• (2025). Strong heteroatomic bond-induced confined restructuring on Ir−Mn intermetallics enable robust PEM water electrolyzers. ANGEW, 64(8), e202420470. (www)

  @article{ , abstract = {Low-iridium acid-stabilized electrocatalysts for efficient oxygen evolution reaction (OER) are crucial for the market deployment of proton exchange membrane (PEM) water electrolysis. Manipulating the in situ reconstruction of Ir-based catalysts with favorable kinetics is highly desirable but remains elusive. Herein, we propose an atomic ordering strategy to modulate the dynamic surface restructuring of catalysts to break the activity/stability trade-off. Under working conditions, the strong heteroatom-bonded structure triggers rational surface-confined reconstruction to form self-stabilizing amorphous (oxy)hydroxides on the model Ir−Mn intermetallic (IMC). Combined in situ/ex situ characterizations and theoretical analysis demonstrate that the induced strong covalent Ir−O−Mn units in the catalytic layer weaken the formation barrier of OOH* and promote the preferential dynamic replenishment/conversion pathway of H 2 O molecules to suppress the uncontrollable participation of lattice oxygen (about 2.6 times lower than that of pure Ir). Thus, a PEM cell with Ir−Mn IMC as anode “pre-electrocatalyst” (0.24 mg Ir cm −2 ) delivers an impressive performance (3.0 A cm −2 @1.851 V@80 °C) and runs stably at 2.0 A cm −2 for more than 2,000 h with the cost of USD 0.98 per kg H 2 , further validating its promising application. This work highlights surface-confined evolution triggered by strong heteroatom bonds, providing insights into the design of catalysts involving surface reconstruction.}, archive = {J_ANGEW}, author = {Shuang Wang and Yan Shi and Tao Shen and Guangzhe Wang and Yue Sun and Gongwei Wang and Li Xiao and Changfeng Yan and Chundong Wang and Hongfang Liu and Ying Wang and Honggang Liao and Lin Zhuang and Deli Wang}, doi = {10.1002/anie.202420470}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420470}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strong heteroatomic bond-induced confined restructuring on Ir−Mn intermetallics enable robust PEM water electrolyzers}, volume = {64}, year = {2025}, }
• (2025). Photocatalyzed azidofunctionalization of alkenes via radical-polar crossover. ANGEW, 64(8), e202420455. (www)

  @article{ , abstract = {The azidofunctionalization of alkenes under mild conditions using commercially available starting materials and easily accessible reagents is reported based on a radical-polar crossover strategy. A broad range of alkenes, including vinyl arenes, enamides, enol ethers, vinyl sulfides, and dehydroamino esters, were regioselectively functionalized with an azide and nucleophiles such as azoles, carboxylic acids, alcohols, phosphoric acids, oximes, and phenols. The method led to a more efficient synthesis of 1,2-azidofunctionalized pharmaceutical intermediates when compared to previous approaches, resulting in both reduction of step count and increase in overall yield. The scope and limitations of these transformations were further investigated through a standard unbiased selection of 15 substrate combinations out of 1,175,658 possible using a clustering technique.}, archive = {J_ANGEW}, author = {Pierre Palamini and Alexandre A. Schoepfer and Jerome Waser}, doi = {10.1002/anie.202420455}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420455}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalyzed azidofunctionalization of alkenes via radical-polar crossover}, volume = {64}, year = {2025}, }
• (2025). Construction of linear tetramer-type acceptors for high-efficiency and high-stability organic solar cells. ANGEW, 64(8), e202420453. (www)

  @article{ , abstract = {Thanks to the development of non-fullerene acceptor (NFA) materials, the photovoltaic conversion efficiency (PCE) of organic solar cells (OSCs) has exceeded 20 %, which has met the requirements for commercialisation. In the current stage, the main focus is to balance the performance and stability. It has been shown that all-polymer formulation can improve device stability, however, PCE is not in satifsfaction, and the batch-to-batch variation leads to quality control issues. In this work, we constructed monodispersed tetramer NFA materials named G-1 and G-2, to best integrate the merits of small molecule and polymer. Density functional theory (DFT) calculations and experimental results showed that different connecting units at the centre could significantly affect the molecular planarity and thin film morphology. The alkene-bonded tetramer G-1 had a more regioregular structure, which leads to better molecular planarity, and more ordered packing in thin film. More importantly, the oligomeration induced a favourable face-on orientation, achieved a lower binding energy and exhibited a higher photoluminescence yield. As a result, the exciton and charge carrier kinetics was optimized with reduced non-radiative energy loss. The OSC based on PM6 : G-1 achieved a PCE of 19.6 %, which is the highest PCE reported so far for oligomer-based binary OSC. In addition, the device stability was largely improved, showing a lifetime over 10000 hours in the inverted OSC device.}, archive = {J_ANGEW}, author = {Rui Zeng and Jiawei Deng and Xiaonan Xue and Sengke Tan and Lixuan Kan and Yi Lin and Wenkai Zhong and Lei Zhu and Fei Han and Yuhao Zhou and Xingyu Gao and Ming Zhang and Yongming Zhang and Shengjie Xu and Feng Liu}, doi = {10.1002/anie.202420453}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420453}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of linear tetramer-type acceptors for high-efficiency and high-stability organic solar cells}, volume = {64}, year = {2025}, }
• (2025). CO2-driven oxygen vacancy diffusion and healing on TiO2(110) at ambient pressure. ANGEW, 64(8), e202420449. (www)

  @article{ , abstract = {Understanding how TiO 2 interacts with CO 2 at the molecular level is crucial in the CO 2 reduction toward value-added energy sources. Here, we report in situ observations of the CO 2 activation process on the reduced TiO 2 (110) surface at room temperature using ambient pressure scanning tunneling microscopy. We find that oxygen vacancies (V o ) diffuse dynamically along the bridging oxygen (O br ) rows of the TiO 2 (110) surface under ambient CO 2 (g) environments. This physical phenomenon exclusively occurs when the oxygen abstracted upon CO 2 dissociation instantly occupies the V o sites of O br rows on the TiO 2 (110), whereas the TiO 2 (110) surface without the V o only allows CO 2 physisorption on five-fold-coordinated Ti 4+ sites. Synchrotron-based ambient pressure X-ray photoelectron spectroscopy also identifies the changes in surface oxidation states of TiO 2 (110) by the healing of V o sites or the CO 2 physisorption under ambient CO 2 (g) conditions. Density functional theory calculations propose a mechanism of the CO 2 -driven V o diffusion and the physisorbed CO 2 configurations. Our combined results unravel the critical role of defect sites on TiO 2 in determining the elementary step of CO 2 activation during chemical reactions.}, archive = {J_ANGEW}, author = {Young Jae Kim and Hyuk Choi and Daeho Kim and Yongman Kim and Ki-jeong Kim and Jeongjin Kim and Geoff Thornton and Hyun You Kim and Jeong Young Park}, doi = {10.1002/anie.202420449}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420449}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CO2-driven oxygen vacancy diffusion and healing on TiO2(110) at ambient pressure}, volume = {64}, year = {2025}, }
• (2025). Unveiling chirality in MoS2 nanosheets: A breakthrough in phase engineering for enhanced chiroptical properties. ANGEW, 64(8), e202420437. (www)

  @article{ , abstract = {The development of new synthetic strategies to introduce and control chirality in inorganic nanostructures has been highly stimulated by the broad spectrum of potential applications of these exiting nanomaterials. Molybdenum disulfide is among the most investigated transition metal dichalcogenides due to its promising properties for applications that spread from optoelectronic to spintronic. Herein, we report a new two-step approach for the production of chiroptically active semiconductor 2H MoS 2 nanosheets with chiral morphology based on the manipulation of their crystallographic structure. In the first step, metastable metallic 1T MoS 2 nanosheets with chiral morphology were produced via hydrothermal synthesis. Then, thermal annealing was used to progressively tune the conversion of the metallic 1T phase into the thermodynamically stable semiconductor 2H phase while preserving the nanocrystals’ chiral morphology. Our detailed study covers the evolution of the chiroptical properties of the material during the crystallographic phase transition, revealing critical insights into the formation of chiroptically active excitonic transitions. This study represents a unique approach to the production of high-quality chiral nanomaterials by exploiting phase engineering, and paves the way for the development of new synthetic methods to further expand the range and properties of chiral nanomaterials.}, archive = {J_ANGEW}, author = {Lorenzo Branzi and Lucy Fitzsimmons and Igor Chunin and Igor Shvets and Yurii K. Gun'ko}, doi = {10.1002/anie.202420437}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420437}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling chirality in MoS2 nanosheets: A breakthrough in phase engineering for enhanced chiroptical properties}, volume = {64}, year = {2025}, }
• (2025). Rational molecular design for balanced locally excited and charge- transfer nature for two-photon absorption phenomenon and highly efficient TADF-based OLEDs. ANGEW, 64(8), e202420417. (www)

  @article{ , abstract = {The pursuit of highly efficient thermally activated delayed fluorescence (TADF) emitters with two-photon absorption (2PA) character is hampered by the concurrent achievement of a small singlet-triplet energy gap (Δ E ST ) and high photoluminescence quantum yield ( Φ PL ). Here, by introducing a terephthalonitrile unit into a sterically crowded donor-π-donor structure, inducing a hybrid electronic excitation character, we designed unique TADF emitters possessing 2PA ability. This rational molecular design was achieved through a main π-conjugated donor-acceptor-donor backbone in line with locally excited feature renders a large oscillator strength and transition dipole moment, maintaining a high 2PA cross-section value. The ancillary N-donor-acceptor-donor with charge transfer character highly balances the TADF phenomenon by minimizing Δ E ST . A near-unity Φ PL value with a large radiative decay rate over an order of magnitude higher than the intersystem crossing rate and a high horizontal orientation ratio of 0.95 were simultaneously attained for TPCz2NP . The organic light-emitting diodes fabricated with this material exhibit a high maximum external quantum efficiency of 25.4 % with an elevated 2PA cross-section ( σ 2 ) value up to 143 GM at 850 nm. These findings offer a venue for designing high-performance TADF emitters with exceptional performance inclusive of 2PA properties, expanding for future functional material design.}, archive = {J_ANGEW}, author = {Gomathi Vinayakam Mageswari and Youhei Chitose and Youichi Tsuchiya and Ja-Hon Lin and Chihaya Adachi}, doi = {10.1002/anie.202420417}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420417}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational molecular design for balanced locally excited and charge- transfer nature for two-photon absorption phenomenon and highly efficient TADF-based OLEDs}, volume = {64}, year = {2025}, }
• (2025). Fluorination from surface to bulk stabilizing high nickel cathode materials with outstanding electrochemical performance. ANGEW, 64(8), e202420413. (www)

  @article{ , abstract = {High nickel layered oxides provide high energy densities as cathodes for next-generation batteries. However, critical issues such as capacity fading and voltage decay, which derive from labile surface reactivity and phase transition, especially under high-rate high-voltage conditions, prevent their commercialization. Here we propose a fluorination strategy to simultaneously introduce F atoms into oxygen layer and create a F aggregated interface. Substitution F for O stabilizes the layered ionic framework as the F ions can anchor the internal transition metal ions through strong TM−F bonding interaction, alleviating anisotropic lattice strain accumulation and release during the cycle, and promoting the Li + dynamics diffusion. Meanwhile, the fluorinated interface induces the formation of a thin and stable CEI, ameliorating the detrimental issues like oxygen vacancy formation, the HF attacks and metal dissolution. The resultant fluorinated cathode delivers a high reversible capacity of 192.9 mAh g −1 at 10 C within the voltage range of 2.7–4.5 V. This fluorination strategy approach provides design concepts for the advanced cathodes that can meet the demands of high-rate and high-voltage applications in next-generation batteries.}, archive = {J_ANGEW}, author = {Jieyu Yang and Guihong Mao and Tengyu Yao and Laifa Shen and Yan Yu}, doi = {10.1002/anie.202420413}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420413}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorination from surface to bulk stabilizing high nickel cathode materials with outstanding electrochemical performance}, volume = {64}, year = {2025}, }
• (2025). Coulombic condensation of liquefied gas electrolytes for li metal batteries at ambient pressure. ANGEW, 64(8), e202420411. (www)

  @article{ , abstract = {The concept of employing highly concentrated electrolytes has been widely incorporated into electrolyte design, due to their enhanced Li-metal passivation and oxidative stability compared to their diluted counterparts. However, issues such as high viscosity and sub-optimal wettability, compromise their suitability for commercialization. In this study, we present a highly concentrated dimethyl ether-based electrolyte that appears as a liquid phase at ambient conditions via Li + - solvents ion-dipole interactions (Coulombic condensation). Unlike conventional high salt concentration ether-based electrolytes, it demonstrates enhanced transport properties and fluidity. The anion-rich solvation structure also contributes to the formation of a LiF-rich salt-derived solid electrolyte interphase, facilitating stable Li metal cycling for over 1000 cycles at 0.5 mA cm −2 , 1 mAh cm −2 condition. When combined with a sulfurized polyacrylonitrile (SPAN) electrode, the electrolyte effectively reduces the polysulfide shuttling effect and ensures stable performance across a range of charging currents, up to 6 mA cm −2 . This research underscores a promising strategy for developing an anion-rich, high concentration ether electrolyte with decreased viscosity, which supports a Li metal anode with exceptional temperature durability and rapid charging capabilities.}, archive = {J_ANGEW}, author = {Yijie Yin and John Holoubek and Kangwoon Kim and Alex Liu and Bhargav Bhamwala and Shen Wang and Bingyu Lu and Kunpeng Yu and Hongpeng Gao and Mingqian Li and Ganesh Raghavendran and Guorui Cai and Weikang Li and Ping Liu and Ying Shirley Meng and Zheng Chen}, doi = {10.1002/anie.202420411}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420411}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coulombic condensation of liquefied gas electrolytes for li metal batteries at ambient pressure}, volume = {64}, year = {2025}, }
• (2025). High-rate lithium-ion capacitor diode towards multifrequency Ion/Electron-coupling logic operations. ANGEW, 64(8), e202420404. (www)

  @article{ , abstract = {Ion/electron-coupling logic operation is recognized as the most promising approach to achieving in-depth brain-inspired computing, but the lack of high-performance ion/electron-coupling devices with high operating frequencies much restricts the fast development of this field. Accordingly, we herein report an orthorhombic niobium pentoxide ( T -Nb 2 O 5 ) based lithium-ion capacitor diode (CAPode) that possesses thoroughly improved performances to achieve multifrequency ion/electron-coupling logic operations. Specifically, benefiting from the unique crystal structure and fast ion-transport topology of T -Nb 2 O 5 , the constructed CAPode exhibits a high response frequency of up to 122 Hz, over three orders of magnitude higher than those of the state-of-the-art CAPodes. Meanwhile, the T -Nb 2 O 5 based CAPode delivers a record-high rectification ratio of 108, a high specific capacity of 390 C g −1 , a wide voltage window of −1.5–1.5 V, and a superior cycling stability over 2000 cycles. Combining these performance advantages, the T -Nb 2 O 5 based CAPode is demonstrated to be fully competent in typical AND and OR logic gates over a wide frequency range of 1–100 Hz, validating great potential in the burgeoning field of multifrequency ion/electron-coupling logic operations.}, archive = {J_ANGEW}, author = {Hongyun Ma and Kai Sun and Yunong Cai and Fengfeng Li and Lingxiao Ma and Yifeng Qi and Hongwei Sheng and Liang Wu and Kai Wang and Jun Wang and Yujun Fu and Yang Chai and Wei Lan}, doi = {10.1002/anie.202420404}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420404}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-rate lithium-ion capacitor diode towards multifrequency Ion/Electron-coupling logic operations}, volume = {64}, year = {2025}, }
• (2025). Dual regulation of sensitizers and cluster catalysts in Metal–Organic frameworks to boost h2 evolution. ANGEW, 64(8), e202420398. (www)

  @article{ , abstract = {Photocatalytic efficiency is closely correlated to visible-light absorption ability, electron transfer efficiency and catalytic center activity of photocatalysts, nevertheless, the concurrent management of these factors to improve photocatalytic efficiency remains underexplored. Herein, we proposed a sensitizer/catalyst dual regulation strategy on the polyoxometalate@Metal−Organic Framework (POM@MOF) molecular platform to construct highly efficient photocatalysts. Impressively, Ni−Sb 9 @UiO−Ir−C6, obtained by coupling strong sensitizing [Ir(coumarin 6) 2 (bpy)] + with Ni−Sb 9 POM with extremely exposed nickel site [NiO 3 (H 2 O) 3 ], can drive H 2 evolution with a turnover number of 326923, representing a record value among all the POM@MOF composite photocatalysts. This performance is over 34 times higher than that of the typical Ni 4 P 2 @UiO−Ir constructed from [Ir(ppy) 2 (bpy)] + and Ni 4 P 2 POM. Systematical investigations revealed that dual regulation of sensitizing and catalytic centers endowed Ni−Sb 9 @UiO−Ir−C6 with strong visible-light absorption, efficient inter-component electron transfer and high catalytic activity to concurrently promote H 2 evolution. This work opens up a new avenue to develop highly active POM@MOF photocatalysts by dual regulation of sensitizing/catalytic centers at the molecular level.}, archive = {J_ANGEW}, author = {Song Guo and Chun-Wei Pan and Min Hou and Yi-Tong Hou and Shuang Yao and Tong-Bu Lu and Zhi-Ming Zhang}, doi = {10.1002/anie.202420398}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420398}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual regulation of sensitizers and cluster catalysts in Metal–Organic frameworks to boost h2 evolution}, volume = {64}, year = {2025}, }
• (2025). Unlocking CO2 activation with a novel Ni−Hg−Ni trinuclear complex. ANGEW, 64(8), e202420391. (www)

  @article{ , abstract = {Compounds featuring bonds between mercury and transition metals are of interest for their intriguing/ambiguous bonding and scarcely explored reactivities. We report herein the synthesis and reactivities of the new compound [(POCOP)Ni] 2 Hg, [Ni 2 Hg] , featuring a trinuclear Ni−Hg−Ni core (POCOP= κ P , κ C , κ P' -2,6-( i -Pr 2 PO) 2 C 6 H 3 ). [Ni 2 Hg] reacts with CO 2 to give the carbonate-bridged complex [Ni 2 CO 3 ] . Bubbling CO gas through a solution of [Ni 2 CO 3 ] gave its μ -CO 2 analogue [Ni 2 CO 2 ] , which itself reacts with CO 2 to give back [Ni 2 CO 3 ] , indicating that these two compounds interconvert reversibly. This implies that the formation of [Ni 2 CO 3 ] from [Ni 2 Hg] and CO 2 constitutes a reductive disproportionation of two molecules of CO 2 into CO 3 2− and CO. Tests showed that this process proceeds through three steps, an initial CO 2 insertion to give [Ni 2 CO 2 ] , followed by another CO 2 insertion to give the second intermediate [Ni 2 C 2 O 4 ] , and the latter's decarbonylation to give [Ni 2 CO 3 ] . Although the putative second intermediate could not be isolated, we have shown that it likely features a μ -carbonyl-carbonate rather than a μ -oxalate moiety, because the latter complex is thermally stable to decarbonylation. Reduction of [Ni 2 CO 3 ] with excess Na/Hg regenerates [Ni 2 Hg] , establishing that the observed deoxygenation of CO 2 in this system can, in principle, be catalytic in the presence of excess reductant.}, archive = {J_ANGEW}, author = {Naser Rahimi and Christine Lepetit and Davit Zargarian}, doi = {10.1002/anie.202420391}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420391}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking CO2 activation with a novel Ni−Hg−Ni trinuclear complex}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed enantioselective skeletal editing through a formal nitrogen insertion into indoles to synthesize atropisomeric aminoaryl quinoxalines. ANGEW, 64(8), e202420390. (www)

  @article{ , abstract = {Skeletal editing represents an attractive strategy for adding complexity to a given molecular scaffold in chemical synthesis. Isodesmic reactions provide a complementary skeletal editing approach for the redistribution of chemical bonds in chemical synthesis. However, catalytic enantioselective isodesmic reaction is extremely scarce and enantioselective isodesmic reaction to synthesize atropisomeric compounds is unknown. Herein, we report a facile method to synthesize axially chiral aminoaryl quinoxalines through Cu(I)-catalyzed dearomatization and sequential chiral phosphoric acid (CPA) catalyzed enantioselective isodesmic C−N bond formation and cleavage from indoles and 1,2-diaminoarenes under mild reaction conditions. In this process, the five-membered ring of the indole scaffold was broken and a novel quinoxaline skeleton was constructed. This method allows the practical and atom-economical synthesis of valuable axially chiral aminoaryl quinoxalines in high yields (up to 95 %) and generally excellent enantioselectivities (up to 99 % ee). Notably, this novel type of quinoxaline atropisomers has promising applications in developing axially chiral ligand in asymmetric catalysis. This strategy represents the first example of CPA-catalyzed enantioselective isodesmic reaction to form axially chiral compounds.}, archive = {J_ANGEW}, author = {Xu Zhang and Jin-Qi Zhang and Ze-Hua Sun and Hui-Mei Shan and Jun-Cheng Su and Xiao-Pan Ma and Gui-Fa Su and Li-Ping Xu and Dong-Liang Mo}, doi = {10.1002/anie.202420390}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed enantioselective skeletal editing through a formal nitrogen insertion into indoles to synthesize atropisomeric aminoaryl quinoxalines}, volume = {64}, year = {2025}, }
• (2025). “Double-gene” small molecule as guest component promotes the efficiency of organic solar cells beyond 19.5 %. ANGEW, 64(8), e202420385. (www)

  @article{ , abstract = {Introduction of a guest component into the active layer is a simple yet effective approach to enhance the performance of organic solar cells (OSCs). Despite various guest components successfully employed in the OSCs, efficient guest components require deliberate design and ingenious inspiration, which still remains a big challenge for developing high performance OSCs. In this work, we propose a concept of “structural gene” engineering to create a new “double-gene” small molecule (L-DBDD) by simply combining the structures of both donor PM6 and acceptor L8-BO. L-DBDD inherit the features of both donor and acceptor, which naturally acts as a bridge between donor/acceptor (D/A) interfaces to strengthen D/A interactions and compatibility. Incorporation of this “double-gene” small molecule into the active layer can facilitate rapid charge dissociation and simultaneously optimize molecular packing for efficient charge transport. Consequently, the ternary OSC based on PM6 : L-DBDD : L8-BO blend achieves a top power conversion efficiency (PCE) of 19.51 %, significantly suppressing the binary control device (PCE=18.52 %). These results demonstrate that the design concept of “double-gene” small molecule by combination of the “structural gene” of donor and acceptor provides a simple and meaningful guideline for guest component-assisted highly efficient OSCs.}, archive = {J_ANGEW}, author = {Jiawei Deng and Jiabin Liu and Chengkai Jin and Shaorong Huang and Shijing Zhang and Zhao Qin and Jiaping Xie and Lin Liu and Lie Chen and Yiwang Chen}, doi = {10.1002/anie.202420385}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420385}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Double-gene” small molecule as guest component promotes the efficiency of organic solar cells beyond 19.5 %}, volume = {64}, year = {2025}, }
• (2025). High-entropy zeolitic imidazolate frameworks for dynamic hydrogen isotope separation. ANGEW, 64(8), e202420379. (www)

  @article{ , abstract = {Entropy-driven strategy enables the systematic design of complex systems by using entropy as a quantifiable design parameter for the degree of mixing. In this study, we present mixed-linker zeolitic imidazolate frameworks (ZIFs), sod -ZIF-1 series, that features two types of six-membered rings (6MRs) with aperture sizes of 3.4 Å and 1.7 Å. By adjusting the configurational entropy, the ratio of these 6MRs can be systematically controlled, which significantly influences adsorptive properties, particularly improving the H 2 affinity about 3 times throughout the series. This results in the significant enhancement of retention times in dynamic separation of hydrogen isotopes (D 2 /H 2 ), even over LNG liquefaction temperature. This approach to entropy-driven pore engineering provides new opportunities for enhancing gas adsorption and separation processes.}, archive = {J_ANGEW}, author = {Joohan Nam and Changhyeon Cho and Sungyeop Jung and Minji Jung and Yeongjin Kim and Yejin Hong and Sohyeon Lee and Hyunchul Oh and Wonyoung Choe}, doi = {10.1002/anie.202420379}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420379}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy zeolitic imidazolate frameworks for dynamic hydrogen isotope separation}, volume = {64}, year = {2025}, }
• (2025). Ruthenium-catalyzed α-regioselective hydroboration of allenes. ANGEW, 64(8), e202420370. (www)

  @article{ , abstract = {Hydroboration of allenes is powerful and atom-economic approach to the synthesis of organoboranes, such as the highly versatile allylboranes. However, regarding regiocontrol, existing methods uniformly deliver the boron functionality to the less hindered β- or γ-position, but not the α-position. The latter is particularly challenging for allenes with substantial steric difference between the two terminals and lacking electronic bias (e.g., 1,1-disubstituted allenes). Herein we report the first highly efficient ruthenium-catalyzed hydroboration of allenes featuring exclusive α-regioselectivity, providing access to sterically hindered allyl boranes that are limitedly accessible by conventional methods. DFT studies suggested that the unusual α-regioselectivity is attributed to the disfavored reductive elimination at the γ-position due to the high energy cost required to overcome the agostic interaction and rotation of the key π-allyl intermediates. This protocol is also applicable to the previously unprecedented α-hydroalkynylation and underdeveloped α-hydrosilylation of allenes, thus complementing known catalytic systems and providing convenient access to highly congested yet densely-functionalized allyl silanes and skipped enynes bearing a fully-substituted allylic carbon center. It is expected that this ruthenium-catalyzed system can serve as a new platform for the development of other hydrofunctionalization processes with unorthodox selectivity.}, archive = {J_ANGEW}, author = {Yun-Xuan Tan and Shijia Li and Liang Chen and Jing Huang and Chaoshen Zhang and Lijuan Song and Xinhao Zhang and Yun-Dong Wu and Jianwei Sun}, doi = {10.1002/anie.202420370}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420370}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ruthenium-catalyzed α-regioselective hydroboration of allenes}, volume = {64}, year = {2025}, }
• (2025). Insights into the role of π-electrons of aromatic aldehydes in passivating perovskite defects. ANGEW, 64(8), e202420369. (www)

  @article{ , abstract = {Carbonyl-containing aromatic ketones or aldehydes have been demonstrated to be effective defect passivators for perovskite films to improve performances of perovskite solar cells (PSCs). It has been claimed that both π-electrons within aromatic units and carbonyl groups can, separately, interact with ionic defects, which, however, causes troubles in understanding the passivation mechanism of those aromatic ketone/aldehyde molecules. Herein, we clarify the effect of both moieties in one molecule on the defect passivation by investigating three aromatic aldehydes with varied conjugation planes, namely, biphenyl-4-carbaldehyde (BPCA), naphthalene-2-carbaldehyde (NACA) and pyrene-1-carbaldehyde (PyCA). Our findings reveal that the π-electrons located in the conjugated system do not directly present strong passivation for defects, but enhance the electron cloud density of the carbonyl group augmenting its interaction with defect sites; thereby, with the extended conjugation plane of the three molecules, their defect passivation ability is gradually improved. PSCs incorporating PyCA with the most extended π-electrons delocalization achieve maximum power conversion efficiencies of 25.67 % (0.09 cm 2 ) and 21.76 % (14.0 cm 2 ). Moreover, these devices exhibit outstanding long-term stability, retaining 95 % of their initial efficiency after operation for 1000 hours at the maximum power point.}, archive = {J_ANGEW}, author = {Xiaoqing Jiang. and Lina Zhu and Bingqian Zhang and Guangyue Yang and Likai Zheng and Kaiwen Dong and Yanfeng Yin and Minhuan Wang and Shiwei Liu and Shuping Pang and Xin Guo}, doi = {10.1002/anie.202420369}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420369}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insights into the role of π-electrons of aromatic aldehydes in passivating perovskite defects}, volume = {64}, year = {2025}, }
• (2025). Gold-catalysed intramolecular reaction of alkynes with sulfoximines acting as N- and O-transfer reagents. ANGEW, 64(8), e202420360. (www)

  @article{ , abstract = {Among the nucleophilic oxidants employed in the gold-catalysed oxidation of alkynes, sulphur-based reagents have played a substantial role since the beginning, granting access to the respective gold carbene intermediates. Herein, we describe the first example of the substance class of sulfoximines being used as atom transfer reagents to alkynes in gold catalysis. Based on the transformation of N -(2-alkynylphenyl) sulfoximines to 3 H -indol-3-ones, it is demonstrated that the sulfoximine functionality is capable of selectively transferring first its nitrogen moiety to the alkyne, forming the α-imino gold carbene, which is then oxidised by the released sulfoxide moiety in a second step via a pseudo-intramolecular mechanism—a distinctive feature that differentiates this work mechanistically from earlier studies. A combination of extensive experimental and theoretical studies provides evidence for this mechanistic rationale. As no external reagents for the 1,2-difunctionalisation of the alkyne unit are required, a wide variety of functional groups are tolerated in the transformation, affording the desired 3 H -indol-3-ones in mostly good yields. It was further also showcased that it is possible to combine our methodology with additional transformations of the 3 H -indol-3-one core in one-pot procedures, allowing facile access to C2-quaternary indolin-3-one structures.}, archive = {J_ANGEW}, author = {Alexandra V. Mackenroth and Patrick W. Antoni and Farshad Shiri and Christoph Bendel and Christian Mayer and Jürgen H. Gross and Frank Rominger and Matthias Rudolph and Alireza Ariafard and A. Stephen K. Hashmi}, doi = {10.1002/anie.202420360}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420360}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gold-catalysed intramolecular reaction of alkynes with sulfoximines acting as N- and O-transfer reagents}, volume = {64}, year = {2025}, }
• (2025). Enhancing low-concentration electroreduction of NO to NH3 via potential-controlled active site-intermediate interactions. ANGEW, 64(8), e202420346. (www)

  @article{ , abstract = {Electronic defect states in catalysts are recognized as highly effective active sites for enhancing the low-concentration electroreduction of NO to NH 3 (NORR). Their structures dynamically evolve with applied electrode potentials, allowing the active sites to adjust interactions with intermediates, thereby improving electrocatalytic performance. However, the dynamic changes in these interactions under applied potentials remain poorly understood, hindering the design of more diverse electrocatalytic systems. Herein, we developed a strategy that unitizes electrode potential to control the interactions between active sites and intermediates over oxygen vacancy-modified TiO 2 (V O −TiO 2−x ) to enhance NORR performance. By combining state-of-the-art constant inner potential (CIP) DFT calculations with in situ (spectro)electrochemical measurements, we investigated how the electrode potential influences these interactions in NORR. The results clearly demonstrate that applying an external potential alters the spatial symmetry of degenerate orbitals of Ti 3+ to facilitate the generation of key intermediates for NO-to-NH 3 conversion. Therefore, the V O −TiO 2−x catalyst exhibited superior NORR performance with a NH 3 Faradaic efficiency up to 76.4 % and a high NH 3 yield rate of 632.9 μg h −1 mg cat. −1 under 1.0 vol % NO atmosphere, which is competitive with those of previously reported works under higher NO concentration (above 10 vol %). Remarkably, the NORR process achieved a record-breaking NH 3 yield of 2292.7 μg h −1 mg cat. −1 in a membrane electrode assembly (MEA) electrolyzer under the same conditions. This study opens a new avenue for enhancing electrocatalytic activity by adjusting operating conditions, thereby transcending the limitations of material design.}, archive = {J_ANGEW}, author = {Xiaoxi Guo and Tongwei Wu and Hengfeng Li and Liyuan Chai and Min Liu}, doi = {10.1002/anie.202420346}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420346}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing low-concentration electroreduction of NO to NH3 via potential-controlled active site-intermediate interactions}, volume = {64}, year = {2025}, }
• (2025). Achieving photocatalytic overall nitrogen fixation via an enzymatic pathway on a distorted CoP4 configuration. ANGEW, 64(8), e202420327. (www)

  @article{ , abstract = {Photocatalytic nitrogen (N 2 ) fixation over semiconductors has always suffered from poor conversion efficiency owing to weak N 2 adsorption and the difficulty of N≡N triple bond dissociation. Herein, a Co single-atom catalyst (SAC) model with a C-defect-evoked CoP 4 distorted configuration was fabricated using a selective phosphidation strategy, wherein P-doping and C defects co-regulate the local electronic structure of Co sites. Comprehensive experiments and theoretical calculations revealed that the distorted CoP 4 configuration caused a strong charge redistribution between the Co atoms and adjacent C atoms, minimizing their electronegativity difference. Consequently, the N 2 adsorption pattern switched from an “end-on” to a “side-on” mode with a high N 2 adsorption energy of −1.40 eV and an elongated N−N bond length of 1.20 Å, notably decreasing the N 2 adsorption/activation energy barrier. In the absence of sacrificial agents, the Co SAC achieved excellent photocatalytic overall N 2 fixation performance via an enzymatic pathway. The NH 3 yielding rate peaked at 1249.5 μmol h −1 g −1 with an apparent quantum yield of 3.51 % at 365 nm. Moreover, the selective phosphidation strategy has universality for synthesizing other SACs, such as those containing Ni and Fe. This study offers new insight into co-regulating the electronic structure of SACs for efficient photocatalytic overall N 2 fixation.}, archive = {J_ANGEW}, author = {Xin Wang and Yuqi Zhao and Xi Wu and Bin Zhang and Jian Tian and Wai-Yeung Wong and Fuxiang Zhang}, doi = {10.1002/anie.202420327}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving photocatalytic overall nitrogen fixation via an enzymatic pathway on a distorted CoP4 configuration}, volume = {64}, year = {2025}, }
• (2025). Enantiomorphic site-assisted chain end control stereospecific alternating copolymerization of chiral cyclic diesters. ANGEW, 64(8), e202420316. (www)

  @article{ , abstract = {Stereospecific alternating copolymerization of different chiral cyclic esters is one feasible approach to enrich the structural diversity of copolyesters and tailor their properties. However, dramatically different reactivities of different cyclic esters let a perfectly stereospecific alternating polymerization of these cyclic esters be a challenge, thus the catalyst is required to balance their reactivities. Herein, a remarkable enantiomorphic site effect on chain end control was discovered and successfully utilized to balance the reactivities of highly reactive S , S -lactide ( S, S -LA) and low reactive R , R -ethylglycolide ( R, R -EG)/ R , R -propylglycolide ( R, R -PG) during their heterospecific alternating copolymerization. The enantiomorphic site of R , R -SalenAl complex can increase the relative reactivity of R, R -EG/ R, R -PG and suppress that of S, S -LA, then a perfectly alternating sequence of the copolymer of S, S -LA and R, R -EG/ R, R -PG can be achieved ( P alt =0.96/0.91); inversely, using S , S -SalenAl complex, the significant enantiomorphic site effect enlarges the reactivity difference of two monomers, the alternating level was just 0.70/0.68 even to 0.61. Poly( S, S -LA- alt - R, R -EG) with a high alternating regularity exhibits lower glass transition temperatures and a dramatically higher elongation at break ( ϵ B =449±51 % ( P alt =0.96) vs ϵ B =6±1% ( P alt =0.70)).}, archive = {J_ANGEW}, author = {Ji Xian and Hao Chen and Ge Yao and Fei Chen and Zhichun Chen and Hongzhang Cao and Luya Cao and Xiaobo Pan and Yu Tang and Jincai Wu}, doi = {10.1002/anie.202420316}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420316}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantiomorphic site-assisted chain end control stereospecific alternating copolymerization of chiral cyclic diesters}, volume = {64}, year = {2025}, }
• (2025). Ultra-small metallic nickel nanoparticles on dealuminated zeolite for active and durable catalytic dehydrogenation. ANGEW, 64(8), e202420306. (www)

  @article{ , abstract = {Each step in the catalyst synthesis process plays an important role in tuning the catalyst structures. For zeolite-supported nickel catalysts, we found the conventional calcination-reduction method typically leads to the formation of large nickel particles, but a pre-aging in hydrogen or nitrogen at a low temperature prior to final reduction can result in ultra-small nickel nanoparticles in a metallic state. This pre-aging treatment facilitates the interaction between Ni 2+ cations and silanol nests on zeolite before the decomposition of the metal salt, leading to the formation of nanoparticles with an average diameter of ~1.2 nm. In contrast, the pre-calcination in oxygen caused the Ni 2+ aggregation before the decomposition of the metal salt precursor, yielding nickel nanoparticles larger than 5 nm. Given the structure sensitivity of nickel in cyclohexane dehydrogenation for hydrogen production, the ultra-small nickel nanoparticles exhibited significantly enhanced activity and durability compared to previous nickel catalysts.}, archive = {J_ANGEW}, author = {Huixin Wu and Hai Wang and Yating Lv and Yuexin Wu and Yike Wang and Qingsong Luo and Yu Hui and Lujie Liu and Mengting Zhang and Kunming Hou and Lina Li and Jianrong Zeng and Weili Dai and Liang Wang and Feng-Shou Xiao}, doi = {10.1002/anie.202420306}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420306}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-small metallic nickel nanoparticles on dealuminated zeolite for active and durable catalytic dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Elaborate designed three-dimensional hierarchical conductive MOF/LDH/CF nanoarchitectures for superior capacitive deionization. ANGEW, 64(8), e202420295. (www)

  @article{ , abstract = {Rational exploration of cost-effective, durable, and high-performance electrode materials is imperative for advancing the progress of capacitive deionization (CDI). The integration of multicomponent layered double hydroxides (LDHs) with conjugated conductive metal–organic frameworks ( c -MOFs) to fabricate bifunctional heterostructure electrode materials is considered a complex but promising strategy. Herein, the fabrication of elaborately designed three-dimensional hierarchical conductive MOF/LDH/CF nanoarchitectures (M–CAT/LDH/CF) as CDI anodes via a controllable grafted-growth strategy is reported. In this assembly, carbon fiber (CF) provides exceptional electrical conductivity facilitating rapid ion transfer and acts as a sturdy foundation for even distribution of NiCoCu-LDH nanosheets. Moreover, the well-ordered NiCoCu-LDH further acts as interior templates to create an interface by embedding c-MOFs and aligning two crystal lattice systems, facilitating the graft growth of c-MOFs/LDH heterostructures along the LDH nanosheet arrays on CF, leading to accelerated ion diffusion kinetics. Density functional theory (DFT) confirms the unique structure of M–CAT/LDH/CF promotes interfacial charge transfer from NiCoCu-LDH to M–CAT. This enhancement accelerates ion transfer, decreases ion migration energy, and leads to better ion diffusion kinetics and a smoother Cl − shuttle. Accordingly, the asymmetrical M–CAT/LDH/CF cell exhibited superior specific capacitance (315 F g −1 ), excellent salt adsorption capacity (147.8 mg g −1 ), rapid rate (21.1 mg g −1 min −1 ), and impressive cyclic stability (91.4 % retention rate). This work offers valuable insights for designing heterostructure electrode materials based on three-dimensional interconnected networks, contributing to further advancements in CDI technology.}, archive = {J_ANGEW}, author = {Chang He and Jun Zhang and Dionissios Mantzavinos and Alexandros Katsaounis and Duan-Hui Si and Zhang Yan and Hong-Yu Zhang and Zhu-Wu Jiang}, doi = {10.1002/anie.202420295}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420295}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elaborate designed three-dimensional hierarchical conductive MOF/LDH/CF nanoarchitectures for superior capacitive deionization}, volume = {64}, year = {2025}, }
• (2025). A scenario for a carbon-neutral ammonia-fueled engine mediated by catalytic NH3 cracking and CO2 hydrogenation. ANGEW, 64(8), e202420292. (www)

  @article{ , abstract = {Utilizing near zero-carbon NH 3 as fuel in engines is promising for carbon-neutrality. However, the application of NH 3 into the engine suffers from the intrinsic poor combustion characteristics of NH 3 and the emission of harmful NO x exhausts. Herein, we proposed and successfully confirmed a novel scenario for converting a conventional “CH 4 -fueled” engine to “NH 3 -fueled” engine. Specifically, CH 4 was used to power the internal combustion engine and release CO 2 as the exhaust. Afterwards, we put forward two routes to convert the exhaust and NH 3 into N 2 and CH 4 for enclosing the carbon cycle. The first “spatially decoupled” route splits the exhaust treatment into NH 3 cracking over Ru clusters on the calcined Mg−Al hydrotalcite (Ru/MAO) and CO 2 methanation over a commercial Ni/Al 2 O 3 . Both NH 3 and CO 2 were almost completely converted into the target products under their respective optimal conditions. The second “spatially coupled” route refers to an one-pot reaction of NH 3 and CO 2 into N 2 , CH 4 , and H 2 O. Due to the mismatch of reaction conditions and the competitive adsorption of reactants, the conversions of NH 3 and CO 2 were lowered to 80.1 % and 49.3 %, respectively, over Ru/MAO under 1 bar (CO 2 :NH 3 =3 : 8) at 550 °C.}, archive = {J_ANGEW}, author = {Jie Ren and Hongliang Li and Hao Lou and Weili Zhou and Feng Zeng and Yu Wang and Xiaokang Liu and Chalachew Mebrahtu and Gang Pei and Jing-Pei Cao and Tao Yao and Zhandong Wang and Jie Zeng}, doi = {10.1002/anie.202420292}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420292}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A scenario for a carbon-neutral ammonia-fueled engine mediated by catalytic NH3 cracking and CO2 hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Excitation-dependent circularly polarized luminescence inversion driven by dichroic competition of achiral dyes in cholesteric liquid crystals. ANGEW, 64(8), e202420290. (www)

  @article{ , abstract = {The development of stimuli-responsive chiral cholesteric liquid crystals (CLCs) materials holds significant potential for achieving three-dimensional (3D) anti-counterfeiting and multi-level information encryption. However, constructing phototunable CLCs systems with easy fabrication and fast response remains a great challenge. Herein, we exploit an excitation-dependent CLCs ( ExD-CLCs ) material by establishing dynamically photoresponsive dichroic competition between two achiral dyes: a negative dichroic dye ( SP-COOH ) and a positive dichroic dye (Nile Red, NR ) within a CLCs medium. The ExD-CLCs exhibits a negative circularly polarized luminescence (CPL) signal ( g lum =−0.16) at 625 nm when excited at 365 nm. Remarkably, under excitation at 430 nm, the CPL signal is inverted, and the g lum value increases to +0.26. Notably, the helical superstructure and handedness of the ExD-CLCs remain unchanged during this reversal process. The CPL signal reversal is driven by the dichroic competition between the SP-COOH dimer, which displays strong negative dichroism in its open-ring isomer form and silent negative dichroism in its closed-ring isomer form, and the NR dye, which exhibits static positive dichroism. Leveraging these excitation-dependent CPL properties, the quadruplex numerical anti-counterfeiting using ExD-CLCs is achieved.}, archive = {J_ANGEW}, author = {Kun Yao and Zhentan Wang and Peng Wang and Yang Li and Liangyu Hu and Yixiang Cheng and Zhongxing Geng}, doi = {10.1002/anie.202420290}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420290}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Excitation-dependent circularly polarized luminescence inversion driven by dichroic competition of achiral dyes in cholesteric liquid crystals}, volume = {64}, year = {2025}, }
• (2025). General and fast Gas–Solid synthesis of functional MXenes and derivatives on the scale of tens of grams. ANGEW, 64(8), e202420287. (www)

  @article{ , abstract = {The rising of MXenes not only enriches the two-dimensional material family but also brings more opportunities for diverse functional applications. However, the controllable synthesis of MXenes is still unsatisfied via the common liquid-solid etching route, considering the unsolved problems like safety risk, time cost and easy oxidation. Herein, a facile yet efficient gas-solid (G-S) reaction methodology is devised by using hydrogen fluoride gas derived from fluorinated organics as the MAX etchant toward high-efficiency fabrication of multiple MXenes and their derivatives. The innovative G-S reaction strategy exhibits superb versatility to achieve different gram-level MXenes (V 2 C, Ti 3 C 2 , Nb 2 C, Ti 2 N, Ti 3 CN, (Mo 2/3 Y 1/3 ) 2 C) in a very short time, and even realizes in situ heteroatom doping or synchronous phase conversion of MXenes directly from MAX phases. The obtained MXenes and their derivatives exhibit excellent structure stability and high electron/ion conductivity, making them promising materials for electrochemical applications. In particular, the N-doped V 2 C MXene shows superior adsorption and catalytic activity toward lithium polysulfides for advanced lithium sulfur batteries.}, archive = {J_ANGEW}, author = {Yang Liu and Sen Liu and Guoqiang Zhao and Maoqiang Shen and Xinyue Gao and Yanhao Zhao and Xuesen Liu and Linrui Hou and Changzhou Yuan}, doi = {10.1002/anie.202420287}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420287}, shortjournal = {Angew. Chem. Int. Edit.}, title = {General and fast Gas–Solid synthesis of functional MXenes and derivatives on the scale of tens of grams}, volume = {64}, year = {2025}, }
• (2025). Subtle modifications in interface configurations of Iron/Cobalt phthalocyanine-based electrocatalysts determine molecular CO2 reduction activities. ANGEW, 64(8), e202420286. (www)

  @article{ , abstract = {Strain engineering has emerged as a powerful approach in steering material properties. However, the mechanism and potential limitations remain poorly understood. Here we report that subtle changes in molecular configurations can profoundly affect, conducively or adversely, the catalytic selectivity and product turnover frequencies (TOFs) of CO 2 reduction reaction. Specifically, introducing molecular curvature in cobalt tetraaminophthalocyanine improves the multielectron reduction activity by favorable *CO hydrogenation, attaining methanol Faradaic efficiency up to 52 %. In stark contrast, strained iron phthalocyanine exacerbates *CO poisoning, leading to decreased TOF CO by >50 % at −0.5 V RHE and a rapid current decay. The uniform dispersion is crucial for optimizing electron transfer, while activity is distinctly sensitive to the local atomic environment around the active sites. Specifically, local strain either enhances binding to intermediates or poisons the catalytic sites. Our comprehensive analysis elucidates the intricate relationship between molecular structure and activities, offering insights into designing efficient heterogeneous molecular interfaces.}, archive = {J_ANGEW}, author = {Yinger Xin and Charles B. Musgrave and Jianjun Su and Jiangtong Li and Pei Xiong and Molly Meng-Jung Li and Yun Song and Qianfeng Gu and Qiang Zhang and Yong Liu and Weihua Guo and Le Cheng and Xuefeng Tan and Qiu Jiang and Chuan Xia and Ben Zhong Tang and William A. Goddard and Ruquan Ye}, doi = {10.1002/anie.202420286}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420286}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Subtle modifications in interface configurations of Iron/Cobalt phthalocyanine-based electrocatalysts determine molecular CO2 reduction activities}, volume = {64}, year = {2025}, }
• (2025). Polyoxotungstate featuring zinc-ion-triggered structural transformation as an efficient electrolyte additive for aqueous zinc-ion batteries. ANGEW, 64(8), e202420284. (www)

  @article{ , abstract = {It is promising but still challenging for the widespread application of aqueous zinc batteries due to the poor reversibility of the zinc anode caused by prevalent dendrite growth and pronounced interfacial side reactions. Herein, we report a rare soluble and water-stable high-nuclearity {Nd 9 Si 4 W 39 } polyoxotungstate. Interestingly, upon encountering Zn 2+ ions, the discrete {Nd 9 Si 4 W 39 } nanocluster undergoes a structural transformation to form an infinitely extended cluster-based {[Zn(H 2 O) 4 ] 3 [Nd 9 Si 4 W 39 ] 2 } two-dimensional honeycomb layer, with which atomic-level Zn 2+ ion effects in reconstructing the layer are determined. More interestingly, we demonstrate that the structural transformation property renders the {Nd 9 Si 4 W 39 } cluster an efficient electrolyte additive for aqueous zinc batteries, enabling the formation of the 2D layer as a protective layer on the zinc anode, significantly enhancing the reversibility of the zinc anode. Compared to the pristine Zn//Zn symmetric battery, the Zn//Zn symmetric battery with the {Nd 9 Si 4 W 39 } additive exhibits an extended lifespan of over 2000 hours at a current density of 1 mA cm −2 . In situ optical microscopy, Raman spectroscopy, and molecular dynamics simulations reveal that the formation of the protective layer effectively promotes uniform zinc deposition, and inhibits zinc agglomeration, dendrite growth, and side reactions, thereby enabling the zinc anode to exhibit high reversibility and long-term service life.}, archive = {J_ANGEW}, author = {Yi Chen and Ze-Xun Zhang and Ping-Wei Cai and Zheng-Wei Guo and Zhi-Wen Lu and Cai Sun and Xin-Xiong Li and Jun-Xiang Chen and Zhen-Hai Wen and Shou-Tian Zheng}, doi = {10.1002/anie.202420284}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420284}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyoxotungstate featuring zinc-ion-triggered structural transformation as an efficient electrolyte additive for aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Boosting c2+ alcohols selectivity and activity in high-current CO electroreduction using synergistic Cu/Zn co-catalysts. ANGEW, 64(8), e202420283. (www)

  @article{ , abstract = {The electrosynthesis of multi-carbon (C 2+ ) alcohols, specifically ethanol and n-propanol through CO electroreduction (CORR) in H 2 O, presents a sustainable pathway for intermittent renewable energy storage and a low-carbon economy. However, achieving high selectivity for alcohol production at industrial current densities is kinetically hampered by side reactions such as ethylene generation and hydrogen evolution reaction, which result from competing adsorption of *CO and *H. In this study, we developed a Cu/Zn alloy catalyst to simultaneously enhance the activity and selectivity for alcohol production by increasing CO capture capacity and enriching active hydrogen on Cu sites. Our findings demonstrate that the Cu/5Zn alloy with a molar ratio of Cu to Zn of 95 : 5 exhibits a Faradaic efficiency of 50 % for the selective electrosynthesis of C 2+ alcohols during ampere-level CO electrolysis. Mechanistic investigations revealed that the Cu/Zn alloy promotes polarized Cu sites, enhancing CO adsorption while facilitating the spillover of hydrogen atoms from Zn to Cu sites, contributing to selective alcohol formation.}, archive = {J_ANGEW}, author = {Zhitan Wu and Nannan Meng and Rong Yang and Maoxin Chen and Jinhui Pan and Sijia Chi and Chao Wu and Shibo Xi and Yuan Liu and Yingqing Ou and Wenya Wu and Shuhe Han and Bin Zhang and Quan-Hong Yang and Kian Ping Loh}, doi = {10.1002/anie.202420283}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420283}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting c2+ alcohols selectivity and activity in high-current CO electroreduction using synergistic Cu/Zn co-catalysts}, volume = {64}, year = {2025}, }
• (2025). Heterogeneous catalysis of molecular-like Au8M(PPh3)8n+ clusters cultivated in mesoporous SBA-15. ANGEW, 64(8), e202420274. (www)

  @article{ , abstract = {It is a dream of researchers to be able to tailor the catalytic performances by adjusting heterogeneous catalysts at the atomic level. Atomically precise metal clusters provide us with the possibility to achieve this challenge. Here, we design a push-and-pull synthesis strategy coupled with TiO x coating to prepare the heterogeneous catalysts denoted as TiO x /Au 8 M@SBA via cultivating atomically precise Au 8 M(PPh 3 ) 8 n+ (M=Pd, Pt or Au; n =2 for Pd/Pt and 3 for Au) clusters in mesoporous molecular sieve. The catalysts are made up of the three functional units, which include Au 8 M(PPh 3 ) 8 n+ clusters that can act as the active sites, the pore environment of the SBA-15 that can announce a catalysis show for the clusters with precise number of atoms maintained during the chemical reactions, and the TiO x coating that can further inhibit the migration of the clusters under reaction conditions. The selective hydrogenation of acetylene performed in the fixed-bed reactor taken, for example, we learn how the atom-by-atom tailoring of a heterogeneous catalyst can switch on elusive heterogeneous mechanisms with cluster catalysis. This work sheds light on the fundamental insight into catalysis origin of heterogeneous catalysts and achieves a distinguished level of detail for cluster catalysis.}, archive = {J_ANGEW}, author = {Tianqi Sun and Bingqing Ge and Shuangshuang Huang and Xiuwen Wang and Yiqi Tian and Xiao Cai and Weiping Ding and Yan Zhu}, doi = {10.1002/anie.202420274}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420274}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterogeneous catalysis of molecular-like Au8M(PPh3)8n+ clusters cultivated in mesoporous SBA-15}, volume = {64}, year = {2025}, }
• (2025). Highly efficient chiral separation based on alkali-proof protein immobilization by covalent organic frameworks. ANGEW, 64(8), e202420269. (www)

  @article{ , abstract = {Chiral separation plays a pivotal role in both practical applications and industrial productions. However, traditional chiral stationary phases (CSPs) exhibit inherent instability in alkaline environments, presenting a significant challenge despite their importance. Herein, basophilic alcalase is creatively developed to fabricate ultrastable protein-based CSPs that can efficiently work under alkaline conditions. An in-depth theoretical simulation is conducted to unveil the unique three-dimensional conformation of alcalase, showing selective affinity towards various enantiomers of chiral amino acids and drugs, especially acidic substrates. Subsequently, an in situ assembly strategy is used to immobilize alcalase within a hydrazone-linked covalent organic framework (COF) platform. The generated protein-based CSPs enable successful baseline separation (R s ≥1.50) for various value-added compounds (e.g., non-steroidal drug, RS-flurbiprofen; nucleotide analog, RS-tenofovir) via high-performance liquid chromatography, surpassing the commercial chiral column. Furthermore, a systematic study reveals that increasing hydrophilicity and pore sizes of COFs can enhance the separation performance. Remarkably, the obtained CSPs demonstrated exceptional durability, maintaining performance for >2,400 runs. This study provides a new member to the protein library for CSPs, and represents an innovative and effective platform for CSPs with immense potential for the enantioseparation of acidic drugs.}, archive = {J_ANGEW}, author = {Mingfang Yang and Yunlong Zheng and Yuqing Cai and Jinbiao Guo and Along Zuo and Jiangyue Yu and Sainan Zhang and Zhenjie Zhang and Yao Chen}, doi = {10.1002/anie.202420269}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient chiral separation based on alkali-proof protein immobilization by covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Bridged carbolong modulating interfacial charge transfer enhancement for high-performance inverted perovskite solar cells. ANGEW, 64(8), e202420262. (www)

  @article{ , abstract = {Efficient regulation of perovskite/C 60 interface is crucial to improving the long-term stability of the inverted perovskite solar cells (PSCs). However, precise methods for controlling the perovskite/C 60 interface have yet to be thoroughly explored. Herein, we develop a carbolong chemical manipulation strategy to improve the interface contact of perovskite/C 60 due to versatile functional groups and excellent optoelectronic properties of carbolong metallaaromatics. And constructing an electron-transfer bridge enhances the interfacial interaction and accelerates interfacial electron transfer. The carbolong manipulation results in optimized energy level alignment, suppressed nonradiative recombination, and improved electronic contact. An impressive efficiency of 25.80% is demonstrated, with open-circuit voltage and fill factor of 1.19 V and 84.53 %, respectively. The unsealed devices retain more than 98 % of their original efficiency after 1400 h of maximum power point tracking under illumination and demonstrate remarkable thermal stability, maintaining 93 % of their initial efficiency after 2500 h at 85 °C in a nitrogen atmosphere. And the encapsulated carbolong-modified module achieved a high efficiency of 20.72 % (active area of 25.25 cm 2 ) with robust operation stability.}, archive = {J_ANGEW}, author = {Yang Yang and Shiyan Chen and Zhiyuan Dai and Hang Wei and Shuyuan Wan and Yan Chen and Jinhan Sun and Zhe Liu and Liming Ding and Haiping Xia and Ruihao Chen and Hongqiang Wang}, doi = {10.1002/anie.202420262}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bridged carbolong modulating interfacial charge transfer enhancement for high-performance inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Unexpected magnetic moments in manganese-doped (CdSe)13 nanoclusters: Role of ligands. ANGEW, 64(8), e202420257. (www)

  @article{ , abstract = {This study explores the enhancement in magnetic and photoluminescence properties of Mn 2+ -doped (CdSe) 13 nanoclusters, significantly influenced by the introduction of paramagnetic centers through doping, facilitated by optimized precursor chemistry and precisely controlled surface ligand interactions. Using a cost-effective and scalable synthesis approach with elemental Se and NaBH 4 (Se-NaBH 4 ) in n-octylamine, we tailored bonding configurations (Cd−O, Cd−N, and Cd−Se) on the surface of nanoclusters, as confirmed by EXAFS analysis. These bonding configurations allowed for tunable Mn 2+ -doping with tetrahedral coordination, further stabilized by hydrogen-bonded acetate ligands, as evidenced by 13 C NMR and IR spectroscopy. Mulliken charge analysis indicates that the charge redistribution on Se 2− suggests electron transfer between surface ligands and the nanocluster, contributing to spin fluctuations. These tailored configurations markedly increased the nanoclusters′ magnetic susceptibility and photoluminescence efficiency. The resulting nanoclusters demonstrated a clear concentration-dependent response in emission lifetimes and intensities upon exposure to magnetic field effects (MFE) and spin-spin coupling, alongside a large magnetic moment exceeding 40 μ B at 180 K. These findings highlight the potential of these nanoclusters for magneto-optical devices and spintronic applications, showcasing their tunable magnetic properties and exciton dynamics.}, archive = {J_ANGEW}, author = {Guo-Lun Huang and Ko.-Yu Ting and Nagaraju Narayanam and Dong-Rong Wu and Tzung-En Hsieh and Kai-Chih Tsai and Da-Wei Yang and Qi-Xun Tang and Bo-Kai Su and Yu-Ting Kang and Shing-Jong Huang and Ching-Hsiang Chen and Yuan-Pin Chang and Lan-Sheng Yang and Yu-Chiang Chao and Elise Yu-Tzu Li and Yi-Hsin Liu}, doi = {10.1002/anie.202420257}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420257}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unexpected magnetic moments in manganese-doped (CdSe)13 nanoclusters: Role of ligands}, volume = {64}, year = {2025}, }
• (2025). Spiro-carbon-locking and sulfur-embedding strategy for constructing deep-red organic electroluminescent emitter with high efficiency. ANGEW, 64(8), e202420253. (www)

  @article{ , abstract = {The discovery of multiple resonance thermally activated delayed fluorescence (MR-TADF) materials with remarkable narrowband emission has opened a new avenue for the development of organic light-emitting diodes (OLEDs) with high color purity. However, the lack of construction strategies for purely red MR-TADF materials significantly impedes their application in full-color high-definition displays. Herein, we propose a unique and handy approach of spiro-carbon-locking and sulfur-embedding strategy to modify the parent MR-TADF framework, resulting in a red MR-TADF emitter with high color purity. The reported MR-TADF molecule (namely, FSBN) demonstrates a pure red emission with an emission maximum of 621 nm in toluene solution. The OLED with FSBN as emitter exhibits Commission Internationale de l’Éclairage (CIE) coordinates of (0.67, 0.33), which exactly matches the red standard defined by the National Television Standards Committee (NTSC). Importantly, the single-host OLED achieves a high power efficiency (PE) of up to 50.1 lm W −1 , suggesting the potential for the development of low power consumption red OLEDs.}, archive = {J_ANGEW}, author = {Yexuan Pu and Xinliang Cai and Yupei Qu and Weibo Cui and Linjie Li and Chenglong Li and Yuewei Zhang and Yue Wang}, doi = {10.1002/anie.202420253}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420253}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spiro-carbon-locking and sulfur-embedding strategy for constructing deep-red organic electroluminescent emitter with high efficiency}, volume = {64}, year = {2025}, }
• (2025). Distinctive photomechanical shape change of p-phenylenediacrylic acid dimethyl ester single crystals induced by a spatially heterogeneous photoreaction. ANGEW, 64(8), e202420243. (www)

  @article{ , abstract = {Understanding photoreaction dynamics in crystals is important for predicting the dynamic property changes accompanying these photoreactions. In this work, we investigate the photoreaction dynamics of p -phenylenediacrylic acid dimethyl ester ( p -PDAMe ) in single crystals that show reaction front propagation, in which the photoreaction proceeds heterogeneously from the edge to the center of the crystal. Moreover, we find that p -PDAMe single crystals exhibit a distinctive crystal shape change from a parallelogram to a distorted shape resembling a fluttering flag, then to a rectangle as the photoreaction proceeds. Density functional theory calculations predict the crystal structure after the photoreaction, providing a reasonable explanation of the distinctive crystal shape change that results from the spatially heterogeneous photoreaction. These results prove that the spatially heterogeneous photoreaction dynamics have the ability to induce novel crystal shape changes beyond what would be expected based on the equilibrium reactant and product crystal shapes.}, archive = {J_ANGEW}, author = {Daichi Kitagawa and Rei Tomoda and Sebastian A. Ramos and Gregory J. O. Beran and Christopher J. Bardeen and Seiya Kobatake}, doi = {10.1002/anie.202420243}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420243}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Distinctive photomechanical shape change of p-phenylenediacrylic acid dimethyl ester single crystals induced by a spatially heterogeneous photoreaction}, volume = {64}, year = {2025}, }
• (2025). 2H NMR as a practical tool for following MOF formation: A case study of UiO-66. ANGEW, 64(8), e202420157. (www)

  @article{ , abstract = {Developing the mechanism for MOF formation is crucial for the rapid development of new materials. This work demonstrates that Deuterium NMR spectroscopy is the optimal inter-laboratory methodology for understanding the in situ kinetics of metal–organic framework (MOF) formation. This method is facile, affordable, and allows for the isolation and monitoring of individual reagents by using one deuterated component while the remaining components are protonated. This study utilizes 2 H NMR, via the spectrometer's lock channel, to investigate the formation of UiO-66 as influenced by different modulators: acetic acid, benzoic acid, and hydrochloric acid. By monitoring the concentration of the deuterated linker and observing the chemical shift and peak width of deuterated water over time, key elements of the mechanism are unraveled. Paradoxically, conditions that cause the ligand to be consumed more slowly result in MOFs forming more quickly and with fewer defects. This phenomenon is attributed to the dissociative mechanism associated with the Zr(IV)-containing node.}, archive = {J_ANGEW}, author = {Amanda P. Parsons and Céline M. Schneider and Michael J. Katz}, doi = {10.1002/anie.202420157}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420157}, shortjournal = {Angew. Chem. Int. Edit.}, title = {2H NMR as a practical tool for following MOF formation: A case study of UiO-66}, volume = {64}, year = {2025}, }
• (2025). Bienzymatic dynamic kinetic resolution of secondary alcohols by Esterification/Racemization in water. ANGEW, 64(8), e202420133. (www)

  @article{ , abstract = {Dynamic kinetic resolution (DKR) is a key method used to prepare optically pure compounds in 100 % theoretical yield starting from racemic substrates by combining the interconversion of substrate enantiomers with an enantioselective transformation. Various chemoenzymatic DKR approaches have been developed to deracemize secondary alcohols, typically requiring an organic solvent to facilitate enantioselective acylation, primarily catalyzed by lipases, alongside racemization mediated by an achiral, non-enzymatic catalyst. Achieving both steps in an aqueous solution remained elusive. Herein, we report a DKR of racemic sec -alcohols in an aqueous solution requiring only two biocatalysts. The first key to success was to achieve fast racemization in a buffer employing a non-stereoselective variant of an alcohol dehydrogenase (Lk-ADH-Prince) via a hydrogen-borrowing oxidation-reduction sequence. Engineered variants of the acyltransferase from Mycobacterium smegmatis (MsAcT) enabled enantioselective acyl transfer in water. Besides the appropriate choice of the enzymes, identifying a suitable acyl donor was a second key to the success. The DKR was successfully demonstrated using ( R )-selective MsAcT variants for a broad range of racemic (hetero)benzylic alcohols with 2,2,2-trifluoroethyl acetate as the acyl donor, yielding ( R )-acetates with up to >99 % conv. and high-to-excellent optical purity (83–99.9 % ee). The ( S )-acetates were accessible using a stereocomplementary ( S )-selective MsAcT variant. Notably, substrate concentrations of up to 400 mM were tolerated in selected cases.}, archive = {J_ANGEW}, author = {Aleksandra Rudzka and Tamara Reiter and Wolfgang Kroutil and Paweł Borowiecki}, doi = {10.1002/anie.202420133}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420133}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bienzymatic dynamic kinetic resolution of secondary alcohols by Esterification/Racemization in water}, volume = {64}, year = {2025}, }
• (2025). Formally zerovalent bis(arene) germylene complexes of zirconium and hafnium. ANGEW, 64(8), e202420114. (www)

  @article{ , abstract = {Tetrachlorides of zirconium and hafnium form adducts ( 2 , 3 ) with an intramolecular germylene phosphine Lewis pair. Two electron reduction treating the adducts with [ Mes NacnacMg] 2 gives the low-valent metal complexes ( 4 , 5 ) featuring η 6 -Trip coordination at the Zr(II) and Hf(II) metal atom. Reduction of the M(II)-complexes gives the zerovalent metal complexes of zirconium ( 6 ) and hafnium ( 7 ), which have been structurally characterized. Two arene moieties and the germylene exhibit metal coordination. Puckered coordination of a P-phenyl unit was observed for both derivatives 6 and 7 . Four electron reduction of a reaction mixture of metal tetrachloride with the germylene phosphine Lewis pair also gives the zerovalent complexes in good yield. Carbonyl complexes were synthesized treating the reduced metal complexes with carbon monoxide. Dimethylbutadiene shows a reaction with an arene moiety and the coordinated germylene ligand of the zerovalent complexes. A cyclohexadienyl and a triorganogermate ligand are formed. For zirconium this reaction is reversible at room temperature.}, archive = {J_ANGEW}, author = {Max J. Eberhardt and Mira Baum and Stefan F. Clewing and Hartmut Schubert and Lars Wesemann}, doi = {10.1002/anie.202420114}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202420114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formally zerovalent bis(arene) germylene complexes of zirconium and hafnium}, volume = {64}, year = {2025}, }
• (2025). Generating strong circularly polarized luminescence from self-assembled films of chiral selenium nanoparticles and upconversion nanoparticles. ANGEW, 64(8), e202419884. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) has garnered significant research attention. Achieving a high luminescence dissymmetry factor (g lum ) is a key challenge in this field. Herein, we reported, for the first time, the fabrication of a chiral assembled film consisting of chiral D-/L- Selenium nanoparticles ( D-/L- Se NPs) and DSPE-PEG-NH 2 modified upconversion nanoparticles (DPNUCNPs) with remarkable CPL properties that were generated by the interfacial self-assembly technique. The chiral Se/DPNUCNPs films, consisting of three layers (3L) of D-/L- Se films and 3L DPNUCNPs films, exhibited the highest circular dichroism (CD) response and the strongest CPL signals. Under laser excitation at 980 nm, the 3L D-/L- Se/3L DPNUCNPs assembled films displayed symmetric CPL signals between 400 and 600 nm, with a maximum |g lum | value of 0.68. The interaction between DPNUCNPs and Se NPs involves energy transfer and chirality transfer, along with the formation of spin-polarized excitons, thereby resulting in CPL activity. Furthermore, the chiral Se/DPNUCNPs films were patterned for anti-counterfeit and encryption applications. Our study provides a novel guide for fabricating chiral nanomaterials with strong CPL response.}, archive = {J_ANGEW}, author = {Hui Zhangsun and Liguang Xu and Aihua Qu and Chuanlai Xu and Hua Kuang and Changlong Hao}, doi = {10.1002/anie.202419884}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202419884}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Generating strong circularly polarized luminescence from self-assembled films of chiral selenium nanoparticles and upconversion nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Deciphering pH mismatching at the electrified Electrode–Electrolyte interface towards understanding intrinsic water molecule oxidation kinetics. ANGEW, 64(8), e202419823. (www)

  @article{ , abstract = {Unveiling the key influencing factors towards electrode/electrolyte interface control is a long-standing challenge for a better understanding of microscopic electrode kinetics, which is indispensable to building up guiding principles for designer electrocatalysts with desirable functionality. Herein, we exemplify the oxygen evolution reaction (OER) via water molecule oxidation with the iridium dioxide electrocatalyst and uncovered the significant mismatching effect of pH between local electrode surface and bulk electrolyte: the intrinsic OER activity under acidic or near-neutral condition was deciphered to be identical by adjusting this pH mismatching. This result indicates that the local pH effect at the electrified solid–liquid interface plays the main role in the “fake” OER performance. This local pH effect on the OER electrode process is further verified by integrating a wide spectrum of analytical approaches. This study will accelerate the understanding of the local proton-induced effect on electrode interface processes and the development of advanced electrochemical activity.}, archive = {J_ANGEW}, author = {Miao Wang and Ken Sakaushi}, doi = {10.1002/anie.202419823}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202419823}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering pH mismatching at the electrified Electrode–Electrolyte interface towards understanding intrinsic water molecule oxidation kinetics}, volume = {64}, year = {2025}, }
• (2025). Probing the protein kinases′ cysteinome by covalent fragments. ANGEW, 64(8), e202419736. (www)

  @article{ , abstract = {Protein kinases are important drug targets, yet specific inhibitors have been developed for only a fraction of the more than 500 human kinases. A major challenge in designing inhibitors for highly related kinases is selectivity. Unlike their non-covalent counterparts, covalent inhibitors offer the advantage of selectively targeting structurally similar kinases by modifying specific protein side chains, particularly non-conserved cysteines. Previously, covalent fragment screens yielded potent and selective inhibitors for individual kinases such as ERK1/2 but have not been applied to the broader kinome. Furthermore, many of the accessible cysteine positions have not been addressed so far. Here, we outline a generalizable approach to sample ATP-site cysteines with fragment-like covalent inhibitors. We present the development of a kinase-focused covalent fragment library and its systematic screening against a curated selection of 47 kinases, with 60 active site-proximal cysteines using LC/MS and differential scanning fluorimetry (DSF) assays, followed by hit validation through various complementary techniques. Our findings expand the repertoire of targetable cysteines within protein kinases, provide insight into unique binding modes identified from crystal structures and deliver isoform-specific hits with promising profiles as starting points for the development of highly potent and selective covalent inhibitors.}, archive = {J_ANGEW}, author = {Guiqun Wang and Nico J. Seidler and Sandra Röhm and Yufeng Pan and Xiaojun Julia Liang and Lisa Haarer and Benedict-Tilman Berger and Saran Aswathaman Sivashanmugam and Valentin R. Wydra and Michael Forster and Stefan A. Laufer and Apirat Chaikuad and Matthias Gehringer and Stefan Knapp}, doi = {10.1002/anie.202419736}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202419736}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing the protein kinases′ cysteinome by covalent fragments}, volume = {64}, year = {2025}, }
• (2025). Defluorinative C−O coupling between trifluoromethylarenes and alcohols via copper photoredox catalysis. ANGEW, 64(8), e202419591. (www)

  @article{ , abstract = {Fluorine-containing compounds have shown unparalleled impacts in the realm of functional molecules, and the ability to prepare novel structures has been crucial in unlocking new properties for applications in pharmaceutical and materials science. Herein, we report a copper-catalyzed, photoinduced defluorinative C−O coupling between trifluoromethylarenes and alcohols. This method allows for direct access to a wide selection of difluorobenzylether (ArCF 2 OR) molecules, including a compound displaying liquid crystal behavior. Through slight modification of the protocol, we were able to generate difluorobenzyliodide (ArCF 2 I) products, another class of synthetically useful fluorine-bearing molecules. Mechanistic investigations first suggested that ArCF 2 I can serve as a reservoir to steadily supply the key ArCF 2 ⋅ radical species. Furthermore, experimental evidence supported a mechanism consisting of two collaborative cycles: C−F activation operated by a homoleptic Cu(I) coordinated by two bisphosphine ligands as the photocatalyst and C−O coupling promoted by a Cu(I) ligated by a single bisphosphine ligand. The critical roles of the two salt additives, lithium iodide and zinc acetate, in orchestrating the two cycles were also elucidated. This dual-role copper catalyst demonstrates the power of base metal photoredox catalysis in achieving both substrate activation and chemical bond formation via a single catalytic system.}, archive = {J_ANGEW}, author = {Priya Saha and Mingoo Jin and Dennis Chung-Yang Huang}, doi = {10.1002/anie.202419591}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202419591}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Defluorinative C−O coupling between trifluoromethylarenes and alcohols via copper photoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Phase-separated spiropyran coacervates as dual-wavelength-switchable reactive oxygen generators. ANGEW, 64(8), e202419538. (www)

  @article{ , abstract = {Low-molecular-weight compounds of certain structural features may form coacervates through liquid-liquid phase separation (LLPS). These coacervates can enter mammalian cells and affect cellular physiology. Controlling the properties of the coacervates inside cells, however, is a challenge. Here, we report photochemical reactions of spiropyran (SP)-based coacervates with two wavelengths of light, in vitro , in the cell, and in animals, generating reactive oxygen species (ROS) for photo-controlled cell killing. We identify an SP-containing compound, SP-PEG 8 -SP, that forms coacervates ( SP-C ) in the aqueous solution. Photo illumination by a UV light triggers the isomerization of SP to merocyanine (MC), switching SP-C to the fluorescent coacervates MC-C . A visible light converts MC-C back to SP-C and induces ROS generation. Notably, coacervate formation increases the compound's ROS generation efficiency. The SP-C / MC-C coacervate system (collectively called spiropyran coacervates) can spontaneously enter cells, and a dual-wavelength-controlled reversible on/off switch and spatiotemporal-resolved ROS production is realized within the cytoplasm. Light-induced ROS generation leads to cytotoxicity to cancer cells, tumor organoids, and tumors in vivo , supporting spiropyran coacervates’ potential use as coacervate photosensitizers in photodynamic therapies.}, archive = {J_ANGEW}, author = {Hao Kong and Xian Xie and Yishu Bao and Fang Zhang and Liming Bian and Kai Cheng and Yuan-Di Zhao and Jiang Xia}, doi = {10.1002/anie.202419538}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202419538}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phase-separated spiropyran coacervates as dual-wavelength-switchable reactive oxygen generators}, volume = {64}, year = {2025}, }
• (2025). Remote hydrogen bonding between ligand and substrate accelerates C–H bond activation and enables switchable site selectivity. ANGEW, 64(8), e202419144. (www)

  @article{ , abstract = {Transition-metal-catalyzed selective and efficient activation of an inert C−H bond in an organic substrate is of importance for the development of streamlined synthetic methodologies. An attractive approach is the design of a metal catalyst capable of recognizing an organic substrate through noncovalent interactions to control reactivity and selectivity. We report here a spirobipyridine ligand that bears a hydroxy group which recognizes pyridine and quinoline substrates through hydrogen bonding, and in combination with an iridium catalyst enables site-selective C−H borylation. The site selectivity can be switched by simply changing the position of the hydroxy group on the ligand. The catalyst also accelerates the reactions, overrides steric bias, and selectively recognizes a pyridine substrate in the presence of other hydrogen bond acceptors. These features are reminiscent of enzymatic catalysis and suggest that judicious design of the recognition group on the ligand can become a general strategy to selectively and efficiently functionalize organic substrates.}, archive = {J_ANGEW}, author = {Pinaki Bhusan De and Kazuhiro Okamoto and Jayakumar Sekar and Sobi Asako and Laurean Ilies}, doi = {10.1002/anie.202419144}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202419144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote hydrogen bonding between ligand and substrate accelerates C–H bond activation and enables switchable site selectivity}, volume = {64}, year = {2025}, }
• (2025). Observation of the smallest three-dimensional neutral boron cluster. ANGEW, 64(8), e202419089. (www)

  @article{ , abstract = {Despite major progress in the investigation of boron cluster anions, direct experimental study of neutral boron clusters remains a significant challenge because of the difficulty in size selection. Here we report a size-specific study of the neutral B 9 cluster using threshold photoionization with a tunable vacuum ultraviolet free electron laser. The ionization potential of B 9 is measured to be 8.45±0.02 eV and it is found to have a heptagonal bipyramid D 7h structure, quite different from the planar molecular wheel of the B 9 - anionic cluster. Chemical bonding analyses reveal superior stability of the bipyramidal structure arising from delocalized σ and π bonding interactions within the B 7 ring and between the B 7 ring and the capping atoms. Photoionization of B 9 breaks the single-electron B-B bond of the capping atoms, which undergo off-axis distortion to enhance interactions with the B 7 ring in the singlet ground state of B 9 + . The single-electron B-B bond of the capping atoms appears to be crucial in stabilizing the D 7h structure of B 9 . This work opens avenues for direct size-dependent experimental studies of a large variety of neutral boron clusters to explore the stepwise development of network structures.}, archive = {J_ANGEW}, author = {Cong-Qiao Xu and Tiantong Wang and Chong Wang and Xin-Ran Dong and Huijun Zheng and Ya Zhao and Li-Li Pan and Jiayue Yang and Weiqing Zhang and Guorong Wu and Hua Xie and Gang Li and Jun Li and Ling Jiang and Xueming Yang and Lai-Sheng Wang}, doi = {10.1002/anie.202419089}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202419089}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Observation of the smallest three-dimensional neutral boron cluster}, volume = {64}, year = {2025}, }
• (2025). Zero-valent copper catalysis enables regio- and stereoselective difunctionalization of alkynes. ANGEW, 64(8), e202418901. (www)

  @article{ , abstract = {The development of a metallic copper-based catalyst system remains a significant challenge. Herein, we report the synthesis of highly stable, active, and reusable Cu 0 catalyst for the carboboration of alkynes using carbon electrophiles and bis (pinacolato)diboron (B 2 pin 2 ) as chemical feedstocks to afford di- and trisubstituted vinylboronate esters in a regio- and stereoselective manner with appreciable turnover number (TON) of up to 2535 under mild reaction conditions. This three-component coupling reaction works well with a variety of substituted electrophiles and alkynes with broad functional group tolerance. In addition, a wide range of terminal and challenging internal alkynes were efficiently converted into hydroborated products in up to >99 % yield with excellent regioselectivity in the absence of carbon electrophiles. X-ray photoelectron spectroscopy and X-ray absorption near-edge spectroscopy (XANES) analysis confirm that the oxidation state of the copper in the catalyst is zero. The broad range of organic transformations, effectiveness, and recyclability of this Cu 0 catalyst are the major achievements that provide an environmentally friendly route for the efficient production of tri- and tetrasubstituted olefins, key intermediates in organic synthesis. The gram-scale reaction and synthetic transformations further highlights the usefulness of these methods.}, archive = {J_ANGEW}, author = {Aishwarya Prakash and Suma Basappa and Rajashri R. Urkude and Ravindra Jangir and Rajendra S. Dhayal and Shubhankar Kumar Bose}, doi = {10.1002/anie.202418901}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202418901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zero-valent copper catalysis enables regio- and stereoselective difunctionalization of alkynes}, volume = {64}, year = {2025}, }
• (2025). Enzyme-inspired single selenium site for selective oxygen reduction. ANGEW, 64(8), e202418897. (www)

  @article{ , abstract = {Learning from nature has garnered significant attention in the scientific community for its potential to inspire creative solutions in material or catalyst design. The study highlights the design of a biomimetic single selenium (Se) site-modified carbon (C) moiety that retains the unique reactivity of selenoenzyme with peroxides, which plays crucial roles in selectively catalyzing the oxygen reduction reaction (ORR). The as-designed Se−C demonstrates nearly 100 % 4-electron selectivity, evidenced by 0.039 % of H 2 O 2 yield at 0.5 V versus reversible hydrogen electrode, outperforming commercial platinum (Pt) by 65 times. In situ X-ray absorption spectroscopy and theoretical calculations attribute this exceptional selectivity to the enzyme-like behaviors of the Se site to steal an O atom from peroxide intermediates. The second achievement is the significantly increased consecutive 2+2 electron selectivity. Benefiting from the enzyme-like H 2 O 2 reduction activity with a higher onset potential of 0.915 V compared to Pt at 0.875 V, the Se−C as a secondary catalytic site reduced the H 2 O 2 yields of the Co−N−C, Fe−N−C, and N−C catalysts by 96 %, 67 %, and 98 %, respectively, via a consecutive 2+2 electron pathway. This also leads to more stable catalysts via protecting the active sites from oxidative attacks. This work establishes new pathways for precise tuning of reaction selectivity in ORR and beyond.}, archive = {J_ANGEW}, author = {Peng-Yang Zhang and Xia Xu and Wen-Song Yu and Zhi-Yao Duan and Huan Huang and Tao Wang and Gang Fu and Zhi-You Zhou and Yu-Cheng Wang and Shi-Gang Sun}, doi = {10.1002/anie.202418897}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202418897}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enzyme-inspired single selenium site for selective oxygen reduction}, volume = {64}, year = {2025}, }
• (2025). B,N-embedded helical nanographenes showing an ion-triggered chiroptical switching function. ANGEW, 64(8), e202418546. (www)

  @article{ , abstract = {Intramolecular oxidative aromatic coupling of 3,6-bis( m -terphenyl-2’-yl)carbazole provided a bis( m -terphenyl)-fused carbazole, while that of 3,6-bis( m -terphenyl-2’-yl)-1,8-diphenylcarbazole afforded a bis(quaterphenyl)-fused carbazole. Borylation of the latter furnished a B,N-embedded helical nanographene binding a fluoride anion via a structural change from the three-coordinate boron to the four-coordinate boron. The anionic charge derived from the fluoride anion is stabilized over the expanded π-framework, which leads to the high binding constant ( K a ) of 1×10 5 M −1 . The four-coordinate boron species was converted back to the parent three-coordinate boron species with Ag + , and the chiroptical switch between the three-coordinate boron and four-coordinate boron species has been achieved via the ion recognition with the change in the color and g lum values.}, archive = {J_ANGEW}, author = {Chihiro Maeda and Sayaka Michishita and Issa Yasutomo and Tadashi Ema}, doi = {10.1002/anie.202418546}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202418546}, shortjournal = {Angew. Chem. Int. Edit.}, title = {B,N-embedded helical nanographenes showing an ion-triggered chiroptical switching function}, volume = {64}, year = {2025}, }
• (2025). Synthetic biomolecular condensates: Phase-separation control, cytomimetic modelling and emerging biomedical potential. ANGEW, 64(8), e202418431. (www)

  @article{ , abstract = {Liquid-liquid phase separation towards the formation of synthetic coacervate droplets represents a rapidly advancing frontier in the fields of synthetic biology, material science, and biomedicine. These artificial constructures mimic the biophysical principles and dynamic features of natural biomolecular condensates that are pivotal for cellular regulation and organization. Via adapting biological concepts, synthetic condensates with dynamic phase-separation control provide crucial insights into the fundamental cell processes and regulation of complex biological pathways. They are increasingly designed with the ability to display more complex and ambitious cell-like features and behaviors, which offer innovative solutions for cytomimetic modeling and engineering active materials with sophisticated functions. In this minireview, we highlight recent advancements in the design and construction of synthetic coacervate droplets; including their biomimicry structure and organization to replicate life-like properties and behaviors, and the dynamic control towards engineering active coacervates. Moreover, we highlight the unique applications of synthetic coacervates as catalytic centers and promising delivery vehicles, so that these biomimicry assemblies can be translated into practical applications.}, archive = {J_ANGEW}, author = {Siyu Song and Tsvetomir Ivanov and Thao. P. Doan-Nguyen and Lucas Caire da Silva and Jing Xie and Katharina Landfester and Shoupeng Cao}, doi = {10.1002/anie.202418431}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202418431}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthetic biomolecular condensates: Phase-separation control, cytomimetic modelling and emerging biomedical potential}, volume = {64}, year = {2025}, }
• (2025). Divergent activity shifts of tin-based catalysts for electrochemical CO2 reduction: PH-dependent behavior of single-atom versus polyatomic structures. ANGEW, 64(8), e202418228. (www)

  @article{ , abstract = {Tin (Sn)-based catalysts have been widely studied for electrochemical CO 2 reduction reaction (CO 2 RR) to produce formic acid, but the intricate influence of the structural sensitivity in single-atom Sn (e.g., Sn−N−C) and polyatomic Sn (e.g., SnO x and SnS x ; x =1,2) on their pH-dependent performance remains enigmatic. Herein, we integrate large-scale data mining (with >2,300 CO 2 RR catalysts from available experimental literature during the past decade), ab initio computations, machine learning force field accelerated molecular dynamic simulations, and pH-field coupled modelling to unravel their pH dependence. We reveal a fascinating contrast: the electric field response of the binding strength of *OCHO on Sn−N 4 −C and polyatomic Sn exhibits opposite behaviors due to their differing dipole moment changes upon *OCHO formation. Such response leads to an intriguing opposite pH-dependent volcano evolution for Sn−N 4 −C and polyatomic Sn. Subsequent experimental validations of turnover frequency and current density under both neutral and alkaline conditions well aligned with our theoretical predictions. Most importantly, our analysis suggests the necessity of distinct optimization strategies for *OCHO binding energy on different types of Sn-based catalysts.}, archive = {J_ANGEW}, author = {Yuhang Wang and Di Zhang and Bin Sun and Xue Jia and Linda Zhang and Hefeng Cheng and Jun Fan and Hao Li}, doi = {10.1002/anie.202418228}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202418228}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent activity shifts of tin-based catalysts for electrochemical CO2 reduction: PH-dependent behavior of single-atom versus polyatomic structures}, volume = {64}, year = {2025}, }
• (2025). Orthorhombic covalent organic frameworks with fmj topology as photocatalyst for hydrogen evolution. ANGEW, 64(8), e202418086. (www)

  @article{ , abstract = {Three-dimensional covalent organic frameworks (3D COFs), a class of highly porous crystalline polymers, have exhibited great potentials in many applications. However, the reported topologies of 3D COFs have been limited to high-symmetry crystal systems, which significantly hindered the development of such functional materials. Herein, we demonstrate the first construction of four highly crystalline orthorhombic 3D COFs with an unprecedented fmj topology, based on judiciously choosing rotatable monomers. Notably, the square monomers in the unit cell of the fmj topological network adopt three different conformations, resulting in a highly complicated 3D network. Moreover, an isomeric pair (3DCOF-CN and 3DCOF-NC), differing only in the orientations of −C=N-bonds, exhibit distinct optoelectronic properties, protonation abilities, and photocatalytic activities, which is the first time to reveal such isomeric effects in 3D COFs. Particularly, a difference of 32-fold in photocatalytic hydrogen evolution rate was observed for the two isomers, with one achieving a superb rate up to ~31.1 mmol h −1 g −1 . This work achieves the first construction of complex orthorhombic 3D COFs, and offers new insights for the development of 3D COF-based high-performance photocatalysts.}, archive = {J_ANGEW}, author = {Wen-Zhuang Wang and Peng-Ju Tian and Yubin Fu and Xiaolong Wan and Xiaoling Lei and Chao Jia and Chao Liu and Qiao-Yan Qi and Shun-Qi Xu and Xin Zhao}, doi = {10.1002/anie.202418086}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202418086}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orthorhombic covalent organic frameworks with fmj topology as photocatalyst for hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Air-mediated biomimetic synthesis of polyhydroxyalkanoate with c4 diol. ANGEW, 64(8), e202417660. (www)

  @article{ , abstract = {Poly(4-hydroxybutyrate) (P4HB) is a high-performance, well-recyclable, and biodegradable polyhydroxyalkanoate (PHA). However, conventional bioproduction of homopolymeric P4HB involves complex and costly processes with C4 feedstocks, particularly 1,4-butanediol (BDO), and enzyme-coenzyme systems in genetically engineered bacteria. An alternative extracellular chemical route utilizing aerial oxidation of BDO offers cost and energy benefits but struggle with conversion efficiency. Inspired by efficient intracellular oxidation of primary alcohols, we propose a ruthenium-phosphine synergistic catalytic system that mimics enzyme-coenzyme functionality. This system effectively catalyzed the air-mediated, solvent-free oxidation of BDO to produce γ-butyrolactone (γ-BL) and oligomeric P4HB, with a space-time yield (10.37 g [γ-BL unit] g −1 catalyst h −1 ) surpassing the values (<5.5) of previous approaches. The oligomer-containing products were reversibly converted to γ-BL and then to P4HB (28.9 kDa) via ring-opening polymerization, exceeding reported values (<16 kDa). This study provides the potential for large-scale synthesis of high-value PHAs from diverse non-grain-based diols, offering economic and environmental advantages.}, archive = {J_ANGEW}, author = {Huilin Xie and Kaibin Zhong and Shihao Niu and Xiaoxu Li and Zexu Hu and Guang Xiao and Yifu Huang and Hongjie Zhang and Yuan Liu and Hefeng Zhang and Qiuquan Cai}, doi = {10.1002/anie.202417660}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202417660}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Air-mediated biomimetic synthesis of polyhydroxyalkanoate with c4 diol}, volume = {64}, year = {2025}, }
• (2025). Copper-catalysed electrochemical CO2 methanation via the alloying of single cobalt atoms. ANGEW, 64(8), e202417008. (www)

  @article{ , abstract = {The electrochemical reduction of carbon dioxide (CO 2 ) to methane (CH 4 ) presents a promising solution for mitigating CO 2 emissions while producing valuable chemical feedstocks. Although single-atom catalysts have shown potential in selectively converting CO 2 to CH 4 , their limited active sites often hinder the realization of high current densities, posing a selectivity-activity dilemma. In this study, we developed a single-atom cobalt (Co) doped copper catalyst (Co 1 Cu) that achieved a CH 4 Faradaic efficiency exceeding 60 % with a partial current density of −482.7 mA cm −2 . Mechanistic investigations revealed that the incorporation of single Co atoms enhances the activation and dissociation of H 2 O molecules, thereby lowering the energy barrier for the hydrogenation of *CO intermediates. In situ spectroscopic experiments and density functional theory simulations further demonstrated that the modulation of the *CO adsorption configuration, with stronger bridge-binding, favours deep reduction to CH 4 over the C−C coupling or CO desorption pathways. Our findings underscore the potential of Co 1 Cu catalysts in overcoming the selectivity-activity trade-off, paving the way for efficient and scalable CO 2 -to-CH 4 conversion technologies.}, archive = {J_ANGEW}, author = {Jiawei Li and Miaojin Wei and Bifa Ji and Sunpei Hu and Jing Xue and Donghao Zhao and Haoyuan Wang and Chunxiao Liu and Yifan Ye and Jilong Xu and Jie Zeng and Ruquan Ye and Yongping Zheng and Tingting Zheng and Chuan Xia}, doi = {10.1002/anie.202417008}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202417008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalysed electrochemical CO2 methanation via the alloying of single cobalt atoms}, volume = {64}, year = {2025}, }
• (2025). Deciphering and enhancing rate-determining step of sodium deposition towards ultralow-temperature sodium metal batteries. ANGEW, 64(8), e202416720. (www)

  @article{ , abstract = {Achieving high ionic conductivity and stable performance at low temperatures remains a significant challenge in sodium-metal batteries (SMBs). In this study, we propose a novel electrolyte design strategy that elucidates the solvation structure-function relationship within mixed solvent systems. A mixture of diglyme and 1,3-dioxolane was developed to optimize the solvation structure towards superior low-temperature electrolyte. Molecular dynamics simulations and Raman spectra results reveal the solvent-separated ion pairs and contact ion pairs dominated solvation structure in the designed electrolyte, displaying a superior ionic conductivity of 1.78×10 −3 S cm −1 at −40 °C. Besides, comprehensive kinetic analysis shows Na + transportation in the electrolyte shows a greater impact on sodium plating than Na + transport through the solid electrolyte interphase or charge transfer. As a result, the electrolyte enables stable operation for over 12,000 hours in Na Na cells at −40 °C. In Na Na 2/3 Ni 1/4 Cu 1/12 Mn 2/3 O 2 full cells, it maintains a high capacity retention of 92.4 % over 600 cycles with an initial specific capacity of 89.4 mAh g −1 at −40 °C, and achieves 81.7 % capacity retention after 50 cycles with an initial specific capacity of 75.3 mAh g −1 at −78 °C. These results pave the way for the development of high-performance SMBs capable of operating under ultralow temperatures.}, archive = {J_ANGEW}, author = {Yuxiang Niu and Jinlin Yang and Fanbin Meng and Zejun Sun and Chonglai Jiang and Yuan Liu and Hongfei Xu and Meng Wang and Haotian Yang and Yupeng Zhu and Gang Wu and Wei Chen}, doi = {10.1002/anie.202416720}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202416720}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deciphering and enhancing rate-determining step of sodium deposition towards ultralow-temperature sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Room-temperature magnetocapacitance spanning 97K hysteresis in molecular material. ANGEW, 64(8), e202416380. (www)

  @article{ , abstract = {Magnetic capacitor, as a new type of device, has broad application prospects in fields such as magnetic field sensing, magnetic storage, magnetic field control, power electronics and so on. Traditional magnetic capacitors are mostly assembled by magnetic and capacitive materials. Magnetic capacitor made of a single material with intrinsic properties is very rare. This intrinsic property is magnetocapacitance (MC). The studies on MC effect have mainly focused on metal oxides so far. No study was reported in molecular materials. Herein, two complexes: (CETAB) 2 [CuCl 4 ] ( 1 ) and (CETAB) 2 [CuBr 4 ] ( 2 ) (CETAB=(2-chloroethyl)trimethylammonium) are reported. There exist strong H−Br and Br−Br interactions and other weak interactions in complex 2 , so the phase transition energy barrier is high, resulting in the widest thermal hysteresis loop on a molecular level to date. Furthermore, complexes 1 and 2 show large MC parameters of 0.247 and 1.614, respectively, which is the first time to observe MC effect in molecular material.}, archive = {J_ANGEW}, author = {Ling-Ao Gui and Jiawei Chen and Yi-Fan Zhang and Long-He Li and Jian-Rong Li and Zhao-Bo Hu and Shi-Yong Zhang and Jinlei Zhang and Zhenyi Zhang and Heng-Yun Ye and Yan Peng and Jing Ma and You Song}, doi = {10.1002/anie.202416380}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202416380}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Room-temperature magnetocapacitance spanning 97K hysteresis in molecular material}, volume = {64}, year = {2025}, }
• (2025). From natural product derivative to hexagonal prism supermolecule: Potent biofilm disintegration, enhanced foliar affinity, and effective management of tomato bacterial canker. ANGEW, 64(8), e202416079. (www)

  @article{ , abstract = {Clavibacter michiganensis ( Cmm ), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid and effective control methodologies. Dense biofilms formed by Cmm shield internal bacteria from host immune defenses and obstruct the ingress of agrochemicals. Even when agrochemicals disintegrate biofilms, splashing and bouncing during application disperse active ingredients away from target sites. Herein, we present a supramolecular strategy to fabricate a hexagonal prism-shaped material, BPGA@CB[8], assembled from an 18 β -glycyrrhetinic acid derivative (PBGA) and host molecule—cucurbit[8]uril (CB[8]) via host–guest recognition. This positively charged material manifests multifaceted functionalities, notably the ability to surmount biofilm barriers, annihilate the encased pathogenic bacteria, and enhance foliar affinity of droplets. The strong in vitro potency and effective deposition of BPGA@CB[8] foster optimal conditions for robust in vivo efficacy, demonstrating superior protective and curative activities (56.9 %/53.4 %) against canker of tomato at a low-dose of 100 μ g⋅mL −1 compared to BPGA (44.6 %/42.2 %), kasugamycin (30.1 %/28.4 %), and thiodiazole copper (35.4 %/31.0 %). This supramolecular material, based on natural product derivatives, provides a potent treatment for high-risk canker of tomato, and exemplifies the utility of supramolecular strategies in optimizing the attributes of natural products for managing plant bacterial diseases.}, archive = {J_ANGEW}, author = {Xue Chen and Run Yang and Kongjun Liu and Min Liu and Qingchuan Shi and Jinghan Yang and Gefei Hao and Laixin Luo and Fengpei Du and Peiyi Wang}, doi = {10.1002/anie.202416079}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202416079}, shortjournal = {Angew. Chem. Int. Edit.}, title = {From natural product derivative to hexagonal prism supermolecule: Potent biofilm disintegration, enhanced foliar affinity, and effective management of tomato bacterial canker}, volume = {64}, year = {2025}, }
• (2025). Multivariate approaches boosting lithium-mediated ammonia electrosynthesis in different electrolytes. ANGEW, 64(8), e202416027. (www)

  @article{ , abstract = {Ammonia electrosynthesis through the lithium-mediated approach has recently reached promising results towards high activity and selectivity in aprotic media, reaching high Faradaic efficiency (FE) values and NH 3 production rates. To fasten the comprehension and optimization of the complex lithium-mediated nitrogen reduction system, for the first time a multivariate approach is proposed as a powerful tool to reduce the number of experiments in comparison with the classical one-factor-at-a-time approach. Doehlert design and surface response methodology are employed to optimize the electrolyte composition for a batch autoclaved cell. The method is validated with the common LiBF 4 salt, and the correlations between the FE and the amount of lithium salt and ethanol as proton donor are elucidated, also discussing their impact on the solid electrolyte interphase (SEI) layer. Moreover, a new fluorinated salt is proposed (i.e., lithium difluoro(oxalate) borate (LiFOB)), taking inspiration from lithium batteries. This salt is chosen to tailor the SEI layer, with the aim of obtaining a bifunctional interfacial layer, both stable and permeable to N 2 , the latter being an essential characteristic for batch systems. The SEI layer composition is confirmed strategic and its tailoring with LiFOB boosts FE values.}, archive = {J_ANGEW}, author = {Anna Mangini and Jon Bjarke Valbæk Mygind and Sara Garcia Ballesteros and Alessandro Pedico and Marco Armandi and Ib Chorkendorff and Federico Bella}, doi = {10.1002/anie.202416027}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202416027}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multivariate approaches boosting lithium-mediated ammonia electrosynthesis in different electrolytes}, volume = {64}, year = {2025}, }
• (2025). Supramolecular spring-like Fe(II) spin-crossover complexes experiencing giant and anisotropic thermal expansion across two distinct temperature regimes. ANGEW, 64(8), e202414826. (www)

  @article{ , abstract = {Dynamic molecules with tunable chemical and physical properties in response to external stimuli hold great potential for applications in various fields such as information storage, smart molecular machines, and biomimetics. Among them, supramolecular springs and spin-crossover (SCO) complexes can both undergo visible macroscopic changes under heat or light stimulation. In this study, we synthesized a unique trinuclear Fe(II)-SCO complex, [( R −L)Fe II {Au(CN) 2 } 2 ] ( R 1 ), using a chiral chelating ligand decorated with rotatable benzyl rings. The [FeAu 2 ] trinuclear molecules form a 2 1 -helical supramolecular chain via elastic Au Au contacts. Interestingly, the synergy between the multiple dynamic factors (SCO event, rotation of the rings, and flexibility in Au Au distance) endows the complex with multiple switchings in both magnetism and structure, as well as the most intriguing characteristic of giant and anisotropic “breathing” feature in thermal expansion within two distinct temperature regimes. Specifically, complex R 1 undergoes two hysteretic magnetic transitions: a non-spin transition between 360 and 380 K and an unsymmetric SCO transition in the region of 160–280 K, associated with a symmetry-breaking event between the non-polar and polar space groups (P2 1 2 1 2 1 ↔P2 1 ). Both transitions are triggered/accompanied by the rotation (inward vs . outward) of the benzyl rings. Correspondingly, reversible spring-like motions of the helical chains with the helical pitches varying from 11.345 140 K to 12.509 280 K then back to 11.630 380 K Å are observed in the two distinct temperature regimes. This work demonstrates a significant success in incorporating both SCO and spring-like motion in one system, paving the way for designing multifunctional dynamic materials for future devices.}, archive = {J_ANGEW}, author = {Xin-Hua Zhao and Yi-Fei Deng and Jing Xi and Jia-Quan Huang and Yuan-Zhu Zhang}, doi = {10.1002/anie.202414826}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202414826}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular spring-like Fe(II) spin-crossover complexes experiencing giant and anisotropic thermal expansion across two distinct temperature regimes}, volume = {64}, year = {2025}, }
• (2025). Mirror-image random nonstandard peptides integrated discovery (MI-RaPID) technology yields highly stable and selective macrocyclic peptide inhibitors for matrix metallopeptidase 7. ANGEW, 64(8), e202414256. (www)

  @article{ , abstract = {Matrix metallopeptidase 7 (MMP7) plays a crucial role in cancer metastasis and progression, making it an attractive target for therapeutic development. However, the development of selective MMP7 inhibitors is challenging due to the conservation of active sites across various matrix metalloproteinases (MMPs). Here, we have developed mirror-image random nonstandard peptides integrated discovery (MI-RaPID) technology to discover innate protease-resistant macrocyclic peptides that specifically bind to and inhibit human MMP7. One identified macrocyclic peptide against D -MMP7, termed D20 , was synthesized in its mirror-image form, D’20 , consisting of 12 D -amino acids, one cyclic β-amino acid, and a thioether bond. Notably, it potently inhibited MMP7 with an IC 50 value of 90 nM, and showed excellent selectivity over other MMPs with similar substrate specificity. Moreover, D’20 inhibited the migration of pancreatic cell line CFPAC-1, but had no effect on the cell proliferation and viability. D’20 exhibited excellent stability in human serum, as well as in simulated gastric and intestinal fluids. This study highlights that MI-RaPID technology can serve as a powerful tool to develop in vivo stable macrocyclic peptides for therapeutic applications.}, archive = {J_ANGEW}, author = {Hiba Ghareeb and Choi Yi Li and Anjana Shenoy and Naama Rotenberg and Julia M. Shifman and Takayuki Katoh and Irit Sagi and Hiroaki Suga and Norman Metanis}, doi = {10.1002/anie.202414256}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202414256}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mirror-image random nonstandard peptides integrated discovery (MI-RaPID) technology yields highly stable and selective macrocyclic peptide inhibitors for matrix metallopeptidase 7}, volume = {64}, year = {2025}, }
• (2025). Tuning co-operative energy transfer in Copper(I) complexes using two-photon absorbing diimine-based ligand sensitizers. ANGEW, 64(8), e202412606. (www)

  @article{ , abstract = {Photocatalysis mediated by low energy light wavelengths has potential to enable safer, sustainable synthetic methods. A phenanthroline-derived ligand bathocupSani , with a large two-photon absorption (TPA) cross section was used to construct a heteroleptic complex [Cu( bathocupSani )( DPEPhos )]BF 4 and a homoleptic complex [Cu( bathocupSani ) 2 ]BF 4 . The ligand and the respective homoleptic complex with copper exhibit two-photon upconversion with an anti-Stokes shift of 1.2 eV using red light. The complex [Cu( bathocupSani ) 2 ]BF 4 promoted energy transfer photocatalysis enabling oxidative dimerization of benzylic amines, sulfide oxidation, phosphine oxidation, boronic acid oxidation and atom-transfer radical addition.}, archive = {J_ANGEW}, author = {Noémie Beaucage and Zujhar Singh and Jérémie Bourdon and Shawn K. Collins}, doi = {10.1002/anie.202412606}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202412606}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning co-operative energy transfer in Copper(I) complexes using two-photon absorbing diimine-based ligand sensitizers}, volume = {64}, year = {2025}, }
• (2025). Interdependence of support wettability - Electrodeposition rate- sodium metal anode and SEI microstructure. ANGEW, 64(8), e202412550. (www)

  @article{ , abstract = {This study examines how current collector support chemistry (sodiophilic intermetallic Na 2 Te vs. sodiophobic baseline Cu) and electrodeposition rate affect microstructure of sodium metal and its solid electrolyte interphase (SEI). Capacity and current (6 mAh cm −2 , 0.5–3 mA cm −2 ) representative of commercially relevant mass loading in anode-free sodium metal battery (AF-SMBs) are analyzed. Synchrotron X-ray nanotomography and grazing-incidence wide-angle X-ray scattering (GIWAXS) are combined with cryogenic ion beam (cryo-FIB) microscopy. Highlighted are major differences in film morphology, internal porosity, and crystallographic preferred orientation e.g. (110) vs. (100) and (211) with support and deposition rate. Within the SEI, sodium fluoride (NaF) is more prevalent with Te−Cu versus sodium hydride (NaH) and sodium hydroxide (NaOH) with baseline Cu. Due to competitive grain growth the preferred orientation of sodium crystallites depends on film thickness. Mesoscale modeling delineates the role of SEI (ionic conductivity, morphology) on electrodeposit growth and onset of electrochemical instability.}, archive = {J_ANGEW}, author = {Chang-An Lo and Yixian Wang and Varun R. Kankanallu and Aditya Singla and Dean Yen and Xiaoyin Zheng and Kaustubh G. Naik and Bairav S. Vishnugopi and Callum Campbell and Vikalp Raj and Chonghang Zhao and Lu Ma and Jianming Bai and Feipeng Yang and Ruipeng Li and Mingyuan Ge and John Watt and Partha P. Mukherjee and David Mitlin and Yu-chen Karen Chen-Wiegart}, doi = {10.1002/anie.202412550}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202412550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interdependence of support wettability - Electrodeposition rate- sodium metal anode and SEI microstructure}, volume = {64}, year = {2025}, }
• (2025). Digital and tunable genetically encoded tension sensors based on engineered coiled-coils. ANGEW, 64(8), e202407359. (www)

  @article{ , abstract = {Genetically encoded tension sensors (GETSs) allow for quantifying forces experienced by intracellular proteins involved in mechanotransduction. The vast majority of GETSs are comprised of a FRET pair flanking an elastic “spring-like” domain that gradually extends in response to force. Because of ensemble averaging, the FRET signal generated by such analog sensors conceals forces that deviate from the average, and hence it is unknown if a subset of proteins experience greater magnitudes of force. We address this problem by developing digital GETSs comprised of coiled-coils (CCs) with tunable mechanical thresholds. We validate the mechanical response of CC digital probes using thermodynamic stability prediction, AlphaFold2 modeling, steered molecular dynamics simulations, and single-molecule force spectroscopy. Live cell measurements using optimized CC tension sensors that are inserted into vinculin demonstrate that 13 % of this mechanosensor experiences forces >9.9 pN within focal adhesions. This reveals greater magnitudes of vinculin force than had previously been reported and demonstrates that CC tension sensors enable more facile and precise tension measurements in living systems.}, archive = {J_ANGEW}, author = {Shuhong Liu and Jinchan Liu and Alexander Foote and Hiroaki Ogasawara and Sarah Al Abdullatif and Victor S. Batista and Khalid Salaita}, doi = {10.1002/anie.202407359}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {8}, pages = {e202407359}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Digital and tunable genetically encoded tension sensors based on engineered coiled-coils}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Artificial lithium channels built from polymers with intrinsic microporosity. ANGEW, 64(7), e202580762. (www)

  @article{ , archive = {J_ANGEW}, author = {Fei Gou and Qiuting Wang and Zihong Yang and Wenju Chang and Jie Shen and Huaqiang Zeng}, doi = {10.1002/anie.202580762}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202580762}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Artificial lithium channels built from polymers with intrinsic microporosity}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Hydrogen-bonded supramolecular network enabled gentle reprogramming of liquid crystal elastomer toward evolutionary robot. ANGEW, 64(7), e202580761. (www)

  @article{ , archive = {J_ANGEW}, author = {Zhenxing Wang and Muqing Si and Junyi Han and Ying Shen and Guangqiang Yin and Kaiyang Yin and Peng Xiao and Tao Chen}, doi = {10.1002/anie.202580761}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202580761}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Hydrogen-bonded supramolecular network enabled gentle reprogramming of liquid crystal elastomer toward evolutionary robot}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Tailoring the properties of chemically recyclable polyethylene-like multiblock polymers by modulating the branch structure (Angew. chem. int. ed. 7/2025). ANGEW, 64(7), e202500811. (www)

  @article{ , archive = {J_ANGEW}, author = {Yucheng Zhao and Emma M. Rettner and Megan E. Battson and Zhitao Hu and Joel Miscall and Nicholas A. Rorrer and Garret M. Miyake}, doi = {10.1002/anie.202500811}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202500811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Tailoring the properties of chemically recyclable polyethylene-like multiblock polymers by modulating the branch structure (Angew. chem. int. ed. 7/2025)}, volume = {64}, year = {2025}, }
• (2025). Yi-hsin liu. ANGEW, 64(7), e202425555. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202425555}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202425555}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Yi-hsin liu}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Tandem-controlled dynamic DNA assembly enables temporally-selective orthogonal regulation of cGAS–STING stimulation (Angew. chem. int. ed. 7/2025). ANGEW, 64(7), e202424929. (www)

  @article{ , archive = {J_ANGEW}, author = {Xiangfei Li and Fangzhi Yu and Lele Li}, doi = {10.1002/anie.202424929}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202424929}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Tandem-controlled dynamic DNA assembly enables temporally-selective orthogonal regulation of cGAS–STING stimulation (Angew. chem. int. ed. 7/2025)}, volume = {64}, year = {2025}, }
• (2025). Back cover: Adsorbate resonance induces water-metal bonds in electrochemical interfaces (Angew. chem. int. ed. 7/2025). ANGEW, 64(7), e202424917. (www)

  @article{ , archive = {J_ANGEW}, author = {Marcus F. Nygaard and Martin L. S. Nielsen and Jan Rossmeisl}, doi = {10.1002/anie.202424917}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202424917}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Adsorbate resonance induces water-metal bonds in electrochemical interfaces (Angew. chem. int. ed. 7/2025)}, volume = {64}, year = {2025}, }
• (2025). Dongliang chao. ANGEW, 64(7), e202424846. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202424846}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202424846}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dongliang chao}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: Correction to “Catalytic linkage engineering of covalent organic frameworks for the oxygen reduction reaction”. ANGEW, 64(7), e202424473. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202424473}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202424473}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: Correction to “Catalytic linkage engineering of covalent organic frameworks for the oxygen reduction reaction”}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Water-soluble aromatic nanobelt with unique cellular internalization (Angew. chem. int. ed. 7/2025). ANGEW, 64(7), e202423696. (www)

  @article{ , archive = {J_ANGEW}, author = {Konstantin Günther and Hideya Kono and Hiroki Shudo and Daisuke Shimizu and Reika Isoda and Masayoshi Nakamura and Akiko Yagi and Kazuma Amaike and Kenichiro Itami}, doi = {10.1002/anie.202423696}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202423696}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Water-soluble aromatic nanobelt with unique cellular internalization (Angew. chem. int. ed. 7/2025)}, volume = {64}, year = {2025}, }
• (2025). Innate immune activation with multifunctional nanoparticles for cancer immunotherapy. ANGEW, 64(7), e202423280. (www)

  @article{ , abstract = {Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers by leveraging the immune system to combat malignancies. However, its efficacy is limited by the immunosuppressive tumor microenvironment and other regulatory mechanisms of the immune system. Innate immune modulators (IIMs) provide potent immune activation to complement adaptive immune responses and help overcome resistance to ICB. This minireview provides an overview of IIMs and their roles in antitumor immune responses and summarizes recent advances in developing nanotechnology to enhance the delivery of IIMs to tumors for potentiating cancer immunotherapy and mitigating systemic toxicity. We discuss innovative nanoparticle platforms for the delivery of IIMs targeting the cyclic GMP-AMP synthase-stimulator of interferon genes pathway, the toll-like receptor pathway, and the retinoic acid-inducible gene I-like receptor pathway. We review the preliminary clinical readouts of representative IIM nanoptherapeutics and highlight the development of multifunctional nanoparticles for combination treatments of IIMs with conventional treatment mdoalities such as chemotherapy, radiotherapy, photodynmic therapy, and tumor antigens. Finally, we summarize the lessons learned from the existing systems, the challenges in the field, and future perspectives for this exciting field of nanotherapeutics for cancer immunotherapy.}, archive = {J_ANGEW}, author = {Xiaomin Jiang and Wenbin Lin}, doi = {10.1002/anie.202423280}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202423280}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Innate immune activation with multifunctional nanoparticles for cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). π-conjugated polymers for high-performance organic electrochemical transistors: Molecular design strategies, applications and perspectives. ANGEW, 64(7), e202423013. (www)

  @article{ , abstract = {The last decade has witnessed significant progress in organic electrochemical transistors (OECTs) due to their enormous potential applications in various bioelectronic devices, such as artificial synapses, biological interfaces, and biosensors. The remarkable advance in this field is highly powered by the development of novel organic mixed ionic/electronic conductors (OMIECs). π-Conjugated polymers (CPs), which are widely used in various optoelectronics, are emerging as key channel materials for OECTs. In this review, after briefly introducing OECT, we then mainly focus on the latest progress in CPs for high-performance OECTs. The correlations of their structure, basic physicochemical properties, and device performance are elucidated by evaluating their electronic characters, optoelectronic properties, and OECT performance. Then, the applications of CP-based OECTs are briefly presented. Finally, we discuss several remaining issues or challenges in this field and give our insights into advancing CPs for enhanced OECT performance.}, archive = {J_ANGEW}, author = {Zhicai Chen and Xinliang Ding and Junwei Wang and Xugang Guo and Shiyang Shao and Kui Feng}, doi = {10.1002/anie.202423013}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202423013}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π-conjugated polymers for high-performance organic electrochemical transistors: Molecular design strategies, applications and perspectives}, volume = {64}, year = {2025}, }
• (2025). Electrosynthesis of organonitrogen compounds via hydroxylamine-mediated cascade reactions. ANGEW, 64(7), e202422637. (www)

  @article{ , abstract = {Hydroxylamine (NH 2 OH) is a key intermediate in the formation of numerous high value-added organonitrogen compounds. The traditional synthesis of NH 2 OH requires the use of precious metals under high temperature conditions, which leads to high cost, high energy consumption, and environmental pollution. The NH 2 OH-mediated cascade reaction integrates the electrochemical synthesis of NH 2 OH and the chemical synthesis of organonitrogen compounds, offering a facile, green, and efficient alternative. This review presents the recent advances on electrosynthesis of high value-added organonitrogen compounds by NH 2 OH-mediated cascade reactions. We present key concepts and the transformation process of different N-species to NH 2 OH, discuss suitable substrates and electrocatalysts, and elucidate the reaction mechanisms involved in generating compounds such as amino acids, cyclohexanone oxime, urea, amine, etc.. Finally, we address current challenges and future directions in this emerging field to encourage further research effort and the development of NH 2 OH-mediated cascade reaction.}, archive = {J_ANGEW}, author = {Meng-Yi Xu and Hong-Yi Tan and Jie Ouyang and Feng-Xuan Zhang and Bing-Hao Wang and Xiong Wang and Sheng Shen and Shuang-Feng Yin}, doi = {10.1002/anie.202422637}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202422637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrosynthesis of organonitrogen compounds via hydroxylamine-mediated cascade reactions}, volume = {64}, year = {2025}, }
• (2025). Porous halogen-bonded frameworks assembled through hetero-polytopic ion pair templation. ANGEW, 64(7), e202422197. (www)

  @article{ , abstract = {Halogen-bonding (XB) interactions have been extensively studied in the preparation of crystalline frameworks, yet porous 3D framework materials built on XBs remain elusive. The donor-acceptor interactions are strengthened by use of anionic XB acceptors; however, the requisite charge-balancing cations typically disrupt the framework and occupy potential void space. In this work, we prepare a tetratopic XB donor bearing a crown ether moiety for sodium cation sequestration. We show that when this ionpair receptor is crystallised with NaCl it gives a 3D framework that is porous to solvent and vapour, and undergoes single-crystal-to-single-crystal reactions.}, archive = {J_ANGEW}, author = {Jordan N. Smith and Callum I. Hunter and Huan V. Doan and Valeska P. Ting and Nicholas G. White}, doi = {10.1002/anie.202422197}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202422197}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porous halogen-bonded frameworks assembled through hetero-polytopic ion pair templation}, volume = {64}, year = {2025}, }
• (2025). Gas-releasing polymer tubesomes: Boosting gas delivery of nanovehicles via membrane stretching. ANGEW, 64(7), e202421405. (www)

  @article{ , abstract = {Hydrogen sulfide (H 2 S), one of the three gas signaling molecules, not only plays a vital role in mediating a series of cellular activities but also manifests exciting applications in clinical therapy. However, one main obstacle in using H 2 S as a gaseous therapeutic agent is to realize on-demand storage and delivery of gas, and thus, it is of great importance to develop H 2 S-donating vehicle platforms. Although a variety of polymer-based gas-releasing carriers have been designed, almost all the systems are limited to spherical structures. Here we explore the role of polymer self-assembled morphologies, especially toward those non-spherical nanostructures, on the H 2 S release capacity. A kind of tubular polymersomes (i.e. tubesomes), formed by the membrane stretching of polythionoester-containing block copolymer vesicles, exhibit enhanced cysteine-responsive H 2 S-releasing behavior in contrast to their spherical counterparts. Moreover, we found that the amount and rate of H 2 S release from diverse polymersomes is relied on the extent of membrane elongation, which allows us to regulate the gas releasing kinetics through tailoring the membrane geometries. More importantly, it is demonstrated that the tubesomes as polymer-type H 2 S donors have better anticancer performance than those spherical polymersomes. This would inspire new possibilities to boost gas therapeutic efficacy through shaping the morphology of gas nanovehicles.}, archive = {J_ANGEW}, author = {Cuiqin Yang and Yulian Zhang and Miaomiao Xu and Jianfeng Li and Qiang Yan}, doi = {10.1002/anie.202421405}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202421405}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gas-releasing polymer tubesomes: Boosting gas delivery of nanovehicles via membrane stretching}, volume = {64}, year = {2025}, }
• (2025). Pd-catalyzed asymmetric hydrogenolysis rearrangement of allylic esters to access axially chiral olefins. ANGEW, 64(7), e202421287. (www)

  @article{ , abstract = {The Pd-catalyzed asymmetric hydrogenolysis rearrangement of allylic acetates using ( s -Bu) 3 BHK has been described, achieving the synthesis of axially chiral alkylidene cycloalkanes with excellent enantioselectivities (up to 99 % ee) and a wide substrate scope (30 examples of cyclohexanes and cyclobutanes). To the best of our knowledge, this is the first time to achieve synthesis of axially chiral olefins via asymmetric hydrogenolysis of allylic acetates. This methodology not only offers a novel synthetic pathway for non-atropisomeric axially chiral structures but also highlights the potential of asymmetric hydrogenolysis as a powerful tool in synthetic organic chemistry.}, archive = {J_ANGEW}, author = {Bing-Ru Shao and Wen-Feng Jiang and Chen Wang and Lei Shi}, doi = {10.1002/anie.202421287}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202421287}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pd-catalyzed asymmetric hydrogenolysis rearrangement of allylic esters to access axially chiral olefins}, volume = {64}, year = {2025}, }
• (2025). A pyrrole-fused nanographene and its edge-perchlorinated derivative featuring a corannulene core and five N-doped heptagons. ANGEW, 64(7), e202420228. (www)

  @article{ , abstract = {A pyrrole-fused analogue of warped nanographene, designated as deca-nitrogen doped ′ WNG ′ ( azaWNG ), was synthesized through the annular fusion of decapyrroylcorannulene. The resulting azaWNG exhibited extremely limited solubility in common organic solvents and was characterized solely by mass spectrometry. Theoretical calculations revealed that azaWNG has a sunflower-like molecular structure with electron-deficient corannulene as the core and electron-rich pyrrole as the petals, demonstrating a significantly narrower energy gap compared to all-carbon WNG . To improve its solubility and facilitate precise structural characterization, iodine monochloride was utilized for edge-perchlorination of azaWNG , enabling successful separation and purification of chlorinated azaWNG in solution phase. X-ray crystallography analysis unequivocally confirmed that edge-perchlorinated azaWNG contains 5 heptagons and 11 pentagons embedded within the warped π skeleton. Cyclic voltammetry measurements indicated that the first oxidation potential of azaWNG is −0.59 V, representing the lowest value reported for any previously studied aza-nanographene. Consequently, azaWNG can be readily oxidized by AgPF 6 or even atmospheric oxygen to yield stable oxidation states, as corroborated by UV/Visible absorption spectroscopy; this behavior is attributed to the fusion of ten pyrroles around corannulene. This work marks the first instance of nitrogen doping in WNG (C 80 H 30 ), underscoring the significant modification to electronic structure induced by such doping.}, archive = {J_ANGEW}, author = {Xue-Peng Zhang and Zuo-Chang Chen and Han-Rui Tian and Wen-Xin Zhang and Si-Wei Ying and Peng Du and Bin-Wen Chen and Yang-Rong Yao and Yin-Fu Wu and Mei-Lin Zhang and Shun-Liu Deng and Qianyan Zhang and Su-Yuan Xie and Lan-Sun Zheng}, doi = {10.1002/anie.202420228}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420228}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A pyrrole-fused nanographene and its edge-perchlorinated derivative featuring a corannulene core and five N-doped heptagons}, volume = {64}, year = {2025}, }
• (2025). Chiral metal self-assemblies of zirconium-tetrahedra and their second harmonic generation activity. ANGEW, 64(7), e202420223. (www)

  @article{ , abstract = {The chirality of metal-organic cages holds enormous potential for novel applications in diverse fields, while it is relatively rare to employ such asymmetric units for the construction of noncentrosymmetric materials. Herein, by self-assembling the 4,4′,4′′-nitrilotribenzoic acid (H 3 NBA) with bis(cyclopentadienyl)-zirconium dichloride (Cp 2 ZrCl 2 , Cp=η 5 -C 5 H 5 ) in different solvent conditions, we have obtained three hierarchical packing modes of metallo-tetrahedra with distinct spatial symmetry groups (designated as Zr-α, Zr-β, and Zr-γ). Among them, Zr-α employs a simple cubic arrangement and is a common centrosymmetric superstructure, which consists of a pair of equimolar metallo-tetrahedra enantiomers in its unit cell. While Zr-β results in conglomerates with spontaneous resolution without using any resolving agents, giving rise to two enantiopure entities separately (Zr-β- P , Zr-β- M ). More importantly, Zr-γ breaks the inversion center of symmetry and crystallizes into a racemic yet non-centrosymmetric superstructure with face-centered cubic packing mode. Based on the non-centrosymmetric nature, the hierarchical superstructure Zr-γ displayed good second harmonic generation activities. This work presents a successful instance wherein the reaction solvent induces the modulation of intermolecular packing mode to afford non-centrosymmetric solid materials, which can greatly promote the development of noncentrosymmetric solid (NCS) materials.}, archive = {J_ANGEW}, author = {Ermeng Han and Yu-Qing Li and Tun Wu and Qixia Bai and Zhe Zhang and Jie Yuan and Wei Liu and Die Liu and Yiming Li and Pingshan Wang}, doi = {10.1002/anie.202420223}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral metal self-assemblies of zirconium-tetrahedra and their second harmonic generation activity}, volume = {64}, year = {2025}, }
• (2025). Chemocatalytic conversion of dinitrogen to ammonia mediated by a tungsten complex. ANGEW, 64(7), e202420220. (www)

  @article{ , abstract = {Whereas molybdenum dinitrogen complexes have played a major role as catalytic model systems of nitrogenase, corresponding tungsten complexes were in most cases found to be catalytically inactive. Herein, we present a modified pentadentate tetrapodal (pentaPod) phosphine ligand in which two dimethylphosphine groups of the pentaPod Me (P5 Me ) ligand have been replaced with phospholanes (Pln). The derived molybdenum complex [Mo(N 2 )P5 Pln ] generates 22 and the analogous tungsten complex [W(N 2 )P5 Pln ] 7 equivalents of NH 3 from N 2 in the presence of 180 equivalents of SmI 2 (THF) 2 /H 2 O, rendering the latter the first tungsten complex chemocatalytically converting N 2 to NH 3 . In contrast, the tungsten complex [W(N 2 )P5 Me ] generates ammonia from N 2 only in a slightly overstoichiometric fashion. The reasons for these reactivity differences are investigated with the help of spectroscopic and electrochemical methods.}, archive = {J_ANGEW}, author = {Anna-Marlene Vogt and Tobias A. Engesser and Jan Krahmer and Niels Michaelis and Mareike Pfeil and Jannik Junge and Christian Näther and Nicolas Le Poul and Felix Tuczek}, doi = {10.1002/anie.202420220}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420220}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemocatalytic conversion of dinitrogen to ammonia mediated by a tungsten complex}, volume = {64}, year = {2025}, }
• (2025). Covalent organic frameworks for boosting H2O2 photosynthesis via the synergy of multiple charge transfer channels and polarized field. ANGEW, 64(7), e202420218. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) serve as one of the most promising candidates for hydrogen peroxide (H 2 O 2 ) photosynthesis, while attaining high-performance COFs remains a formidable challenge due to the insufficient separation of photogenerated charges. Here, through the rational design of bicarbazole-based COFs (Cz-COFs), we showcase the first achievement in piezo-photocatalytic synthesis of H 2 O 2 using COFs. Noteworthily, the ethenyl group-modified Cz-COFs (COF-DH-Eth) demonstrates a record-high yield of H 2 O 2 (9212 μmol g −1 h −1 ) from air and pure water through piezo-photocatalysis, which is ca. 2.5 times higher than that of pristine Cz-COFs without ethenyl groups (COF-DH-H) under identical condition and COF-DH-Eth without ultrasonic treatment. The H 2 O 2 production rate originates from the synergistic effect between an ultrasonication-induced polarized electric field and the spatially separated multiple charge transfer channels, which significantly promote the utilization of photogenerated electrons by directional transfer from bicarbazole groups to the ethenyl group-modified benzene rings. Several Cz-COFs and bifluorenylidene-based COFs (COF-BFTB-H) with similar twisted monomers exhibit obvious piezoelectric performance for promoting H 2 O 2 generation, signifying that organic ligands with a twistable structure play a crucial role in creating broken symmetry structures, thereby establishing piezoelectric properties in COFs.}, archive = {J_ANGEW}, author = {Zifan Li and Zhimin Dong and Zhibin Zhang and Bingqing Wei and Cheng Meng and Wen Zhai and Youqun Wang and Xiaohong Cao and Bin Han and Yunhai Liu}, doi = {10.1002/anie.202420218}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420218}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent organic frameworks for boosting H2O2 photosynthesis via the synergy of multiple charge transfer channels and polarized field}, volume = {64}, year = {2025}, }
• (2025). Dynamic co-clustering and self-sorting in interactive protocell populations. ANGEW, 64(7), e202420209. (www)

  @article{ , abstract = {The design and implementation of collective actions in model protocell communities is an on-going challenge in synthetic protobiology. Herein, we covalently graft alginate or chitosan onto the outer surface of semipermeable enzyme-containing silica colloidosomes to produce hairy catalytic protocells with pH-switchable membrane surface charge. Binary populations of the enzymatically active protocells exhibit self-initiated stimulus-responsive changes in spatial organization such that the mixed community undergoes alternative modes of electrostatically induced self-sorting and reversible co-clustering. We demonstrate that co-clustering, but not self-sorting, mitigates signal attenuation in a binary community of enzyme-containing sender and receiver protocells due to increased proximity effects. The level of signal attenuation is correlated with a time-dependent pH-mediated switch in the spatial organization of the sender and receiver populations. Our results pave the way towards the development of programmable networks of adaptive life-like objects and could have implications for the development of interactive cytomimetic materials and agent-based robotics.}, archive = {J_ANGEW}, author = {Ananya Mishra and Hannah Taylor and Avinash J. Patil and Stephen Mann}, doi = {10.1002/anie.202420209}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420209}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic co-clustering and self-sorting in interactive protocell populations}, volume = {64}, year = {2025}, }
• (2025). Masked divalent reactivity of heterobimetallic lanthanide isocarbonyl complexes. ANGEW, 64(7), e202420207. (www)

  @article{ , abstract = {A new rare-earth reduction system is described in which trivalent yttrium and dysprosium react as though present in their unstable divalent oxidation state. This masked divalent reactivity is achieved using the isocarbonyl-bridged dimers [( M)(μ-Fp)] 2 (M=Y, 1 Y ; M=Dy, 1 Dy ; Cp ttt =1,2,4-C 5 t Bu 3 H 2 ; Fp=CpFe(CO) 2 ), where the reducing electrons originate from the bridging [Fp] − ligands. The reactivity of 1 Y and 1 Dy is showcased by reducing the N-heterocycles 2,2′-bipyridyl (bipy), phenazine (phnz) and hexaazatrinaphthylene (HAN) to give corresponding mono-, di- and tri-metallic rare-earth complexes, respectively, with the heterocyclic ligands present in their singly, doubly and triply reduced forms, respectively. The dynamic magnetic properties of the dysprosium compounds are described. Compound 1 Dy is a single-molecule magnet (SMM) with an appreciable energy barrier of 449(17) cm −1 , whereas [( Dy) 2 (μ-phnz)] ( 3 Dy ) is not an SMM because of a strong, competing equatorial crystal field. Surprisingly, [( Dy) 3 (HAN)] ( 4 Dy ) is also not an SMM, the origins of which are traced to the impact of the tert -butyl substituents on the dysprosium centre and its interaction with the radical [HAN] 3− ligand.}, archive = {J_ANGEW}, author = {Arpan Mondal and Jinkui Tang and Richard A. Layfield}, doi = {10.1002/anie.202420207}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420207}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Masked divalent reactivity of heterobimetallic lanthanide isocarbonyl complexes}, volume = {64}, year = {2025}, }
• (2025). Tailored Metal–Organic framework-based nanozymes for enhanced enzyme-like catalysis. ANGEW, 64(7), e202420200. (www)

  @article{ , abstract = {The global crisis of bacterial infections is exacerbated by the escalating threat of microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure of Pt nanoclusters with finely tuned metal–organic framework (ZIF-8) channel structures for the treatment of infected wounds. Catalytic site normalization showed that the active site of the Pt aggregates structure with fine-tuned pore modifications structure had a catalytic capacity of 14.903×10 5 min −1 , which was 18.7 times higher than that of the Pt particles in monodisperse state in ZIF-8 (0.793×10 5 min −1 ). In situ tests revealed that the change from homocleavage to heterocleavage of hydrogen peroxide at the interface of the nanozyme was one of the key reasons for the improvement of nanozyme activity. Density-functional theory and kinetic simulations of the reaction interface jointly determine the role of the catalytic center and the substrate channel together. Metabolomics analysis showed that the developed nanozyme, working in conjunction with reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading to spontaneous apoptosis and bacterial rupture. This pioneering study elucidates new ideas for the regulation of artificial enzyme activity and provides new perspectives for the development of efficient antibiotic substitutes.}, archive = {J_ANGEW}, author = {Zhichao Yu and Zhenjin Xu and Ruijin Zeng and Man Xu and Minglang Zou and Da Huang and Zuquan Weng and Dianping Tang}, doi = {10.1002/anie.202420200}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420200}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailored Metal–Organic framework-based nanozymes for enhanced enzyme-like catalysis}, volume = {64}, year = {2025}, }
• (2025). Alkene epoxidation with water by confined active co sites on BiVO4 photoanodes under visible light. ANGEW, 64(7), e202420188. (www)

  @article{ , abstract = {Heterogeneous photoelectrocatalysis systems have recently seen significant growth in organic transformations, but are limited by the inherent physicochemical properties of electrode materials. To enhance selectivity in these processes, we propose an innovative advancement in the rational design of photoanodes. Specifically, we incorporated cobalt porphyrin co-catalysts with confined Co sites onto bismuth vanadate films as a photoanode. This photoanode significantly enhances the efficacy of styrene epoxidation, achieving selectivity and conversion rates of 90 % and 99 %, respectively. Notably, the reaction utilizes water as the sole oxygen source, operates at room temperature, and is easily scalable for gram-scale synthesis. The developed photoanode demonstrates robust performance across various alkene substrates. Operando characterizations reveal that during the epoxidation reaction, the confined Co sites within the porphyrin structure catalyze the oxidation of H 2 O to form Co−O*, serving as critical intermediates that facilitate cyclization reactions via one-electron processes. This study introduces an innovative heterogeneous photoelectrocatalysis strategy with customizable active sites tailored for selective catalytic organic transformations.}, archive = {J_ANGEW}, author = {Haisu Wu and Yankun Wang and Meirong Huang and Jiajia Cheng and Baisheng Sa and Yuanxing Fang and Xinchen Wang}, doi = {10.1002/anie.202420188}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alkene epoxidation with water by confined active co sites on BiVO4 photoanodes under visible light}, volume = {64}, year = {2025}, }
• (2025). Hollow pt-encrusted RuCu nanocages optimizing OH adsorption for efficient hydrogen oxidation electrocatalysis. ANGEW, 64(7), e202420177. (www)

  @article{ , abstract = {As one of the best candidates for hydrogen oxidation reaction (HOR), ruthenium (Ru) has attracted significant attention for anion exchange membrane fuel cells (AEMFCs), although it suffers from sluggish kinetics under alkaline conditions due to its strong hydroxide affinity. In this work, we develop ternary hollow nanocages with Pt epitaxy on RuCu (Pt-RuCu NCs) as efficient HOR catalysts for application in AEMFCs. Experimental characterizations and theoretical calculations confirm that the synergy in optimized Pt 8.7 -RuCu NCs significantly modifies the electronic structure and coordination environment of Ru, thereby balancing the binding strengths of H* and OH* species, which leads to a markedly enhanced HOR performance. Specifically, the optimized Pt 8.7 -RuCu NCs/C achieves a mass activity of 5.91 A mg Pt+Ru −1 , which is ~3.3, ~2.2, and ~15.0 times higher than that of RuCu NCs/C (1.38 A mg Ru −1 ), PtRu/C (1.83 A mg Pt+Ru −1 ) and Pt/C (0.37 A mg Pt −1 ), respectively. Impressively, the specific peak power density of fuel cells reaches 15.9 W mg Pt+Ru −1 , significantly higher than those of most reported PtRu-based fuel cells.}, archive = {J_ANGEW}, author = {Licheng Wei and Yuanting Dong and Wei Yan and Yuqi Zhang and Changhong Zhan and Wei-Hsiang Huang and Chih-Wen Pao and Zhiwei Hu and Haixin Lin and Yong Xu and Hongbo Geng and Xiaoqing Huang}, doi = {10.1002/anie.202420177}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420177}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hollow pt-encrusted RuCu nanocages optimizing OH adsorption for efficient hydrogen oxidation electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Insight into robust anion coordination behavior of organic cathode with dual elongated π-conjugated motifs. ANGEW, 64(7), e202420160. (www)

  @article{ , abstract = {Organic electrode materials offer multi-electron reactivity, flexible structures, and redox reversibility, but encounter poor conductivity and durability in electrolytes. To overcome above barriers, we propose a dual elongation strategy of π-conjugated motifs with active sites, involving the extended carbazole and electropolymerized polymer, which enhances electronic conductivity by the electronic delocalization of electron-withdrawing conjugated groups, boosts theoretical capacity by increasing redox-active site density, and endows robust electrochemical stability attributed to the nanonetwork feature of polymer structures. As a proof-of-concept, 5,11-dihydridoindolo[3,2-b]carbazole (DHIC) is selected as the model cathode material for a dual-ion battery, with elongated carbazole groups functioning both as redox-active centers and polymerization anchors. Electrochemical comparisons and theoretical simulations validate the excellent specific capacity, accelerated reaction kinetics, and enhanced anion storage stability imparted by the dual elongated π-conjugated system containing both carbazole motif and electropolymerized DHIC (pDHIC). Simultaneously, the coordination interaction between pDHIC and anions is innovatively evidenced through operando electron paramagnetic resonance spectra. As anticipated, pDHIC cathode delivers an unprecedentedly high specific capacity of 197 mAh/g at 50 mA/g, far outperforming graphite cathodes, and maintains excellent cycling stability with a capacity retention of 86.1 % over 500 cycles. This synergetic strategy sheds light on the performance revolution of organic electrode materials.}, archive = {J_ANGEW}, author = {Xianchun Liu and Jian Shang and Jia Li and Hanlin Liu and Fan Zhang and Qingguang Pan and Yongbing Tang}, doi = {10.1002/anie.202420160}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420160}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Insight into robust anion coordination behavior of organic cathode with dual elongated π-conjugated motifs}, volume = {64}, year = {2025}, }
• (2025). Confinement microenvironment regulation of carbon dots in zeolite for multi-mode time-dependent phosphorescence color evolution. ANGEW, 64(7), e202420156. (www)

  @article{ , abstract = {Matrix immobilization has been proven to be a favored method for enhancing the phosphorescence of carbon dots (CDs), however, it remains a significant challenge to realize time-dependent phosphorescence colors (TDPC) by embedding CDs with single emission center. In this study, we present a novel matrix-controlling strategy to regulate the microenvironment of CDs by doping limited Mn 2+ in zeolite. The surrounding environment influences the surface state of the CDs, leading to the formation of different excitons. At low temperatures, Mn-coordinated CDs (C-CDs) show fast-decaying green phosphorescence, while non-coordinated CDs (NC-CDs) exhibit inherent slow-decaying blue phosphorescence. Notably, the energy transfer occurs between NC-CDs and Mn 2+ to produce an ultrafast-decaying red phosphorescence, with the intensity of the red component increasing as the temperature rises. The interplay of these luminescent centers with distinct decay rates activates fascinating multi-mode TDPC behavior as the temperature changes, resulting in dynamic afterglow evolutions from red to green at 298 K, orange to green at 273 K, and green to cyan to blue at 77 K. Leveraging the diverse luminescence of CDs@MnAPO-5, a multi-dimensional dynamic afterglow color pattern was developed for advanced anti-counterfeiting applications.}, archive = {J_ANGEW}, author = {Siyu Zong and Bolun Wang and Jiani Zhang and Xiaowei Yu and Yida Zhou and Yuze Chen and Tianjun Zhang and Jiyang Li}, doi = {10.1002/anie.202420156}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420156}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Confinement microenvironment regulation of carbon dots in zeolite for multi-mode time-dependent phosphorescence color evolution}, volume = {64}, year = {2025}, }
• (2025). Spatially isomeric fulleropyrrolidines enable controlled stacking of perovskite colloids for high-performance tin-based perovskite solar cells. ANGEW, 64(7), e202420150. (www)

  @article{ , abstract = {The advancement of tin-based perovskite solar cells (TPSCs) has been severely hindered by the poor controllability of perovskite crystal growth and the energy level mismatch between the perovskite and fullerene-based electron transport layer (ETL). Here, we synthesized three cis-configured pyridyl-substituted fulleropyrrolidines (PPF), specifically 2-pyridyl (PPF2), 3-pyridyl (PPF3), and 4-pyridyl (PPF4), and utilized them as precursor additives to regulate the crystallization kinetics during film formation. The spatial distance between the two pyridine groups in PPF2, PPF3, and PPF4 increases sequentially, enabling PPF4 to interact with more perovskite colloidal particles. These interactions effectively enlarge the precursor colloid size and decelerate the crystallization rate of the perovskite, resulting in high-quality PPF4-based perovskite films with reduced defect density and lower exciton binding energy. Additionally, we incorporated a well-defined fullerene bis-adduct, C 60 BB, as an interlayer between the perovskite and PCBM layers to optimize energy level alignment. Through the synergistic effects of PPF4 and C 60 BB, our champion device achieved an efficiency of 16.05 % (certified: 15.86 %), surpassing the 16 % efficiency bottleneck and setting a new benchmark for TPSCs. Moreover, the devices exhibited outstanding stability, retaining 99 % of their initial efficiency after 600 hours of maximum power point tracking under 1 sun condition.}, archive = {J_ANGEW}, author = {Jingfu Chen and Jiefeng Luo and Yuqing Li and Xingyu Chen and Zhiyu Song and Enlong Hou and Chao Sun and Hui Zhang and Shuo Cheng and Yiming Xing and Shanshan Chen and Xinjing Zhao and Liqiang Xie and Chengbo Tian and Zhanhua Wei}, doi = {10.1002/anie.202420150}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420150}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatially isomeric fulleropyrrolidines enable controlled stacking of perovskite colloids for high-performance tin-based perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Phenomics-based discovery of novel orthosteric choline kinase inhibitors. ANGEW, 64(7), e202420149. (www)

  @article{ , abstract = {Choline kinase alpha (CHKA) is a central mediator of cell metabolism linked to cancer and immune regulation. Cellular and clinical evaluation of CHKA has been hampered by challenges in the development of drug-like choline kinase inhibitors. Here, we identify CHKA as an unexpected off-target of histone methyltransferase inhibitors using an integrated phenomic approach. We confirm CHKA as a direct protein target of the aminoquinazolines UNC0638 and UNC0737 using a combination of chemoproteomic, biochemical, cellular, and metabolic profiling assays, possibly explaining the previously reported discrepancies observed for different G9a/GLP inhibitor scaffolds in cellular assays. Using primary human cell model systems, we discover that CHKA modulation impairs IgG secretion and B-cell maturation consistent with the notion that choline metabolism plays an important role in immune signalling. Co-crystal structures of UNC0638 and UNC0737 with CHKA unravel an unexpected binding mode and suggest the inhibitors as attractive starting points for the development of selective chemical tools to further explore the biological role of CHKA in cancer and immune metabolism.}, archive = {J_ANGEW}, author = {Ludwig G. Bauer and Jennifer A. Ward and Laura Díaz-Sáez and Yvonne Sundström and Tuomas Tolvanen and Juan Carlos Alarcón Barrera and Sarantos Kostidis and Catherine M. Rogers and Ioanna Panagakou and Usha Singh and Elisabeth M. Rothweiler and Alejandro Gonzalez Orta and H. Ümit Kaniskan and Jianping Hu and Jian Jin and Sonja Sievers and Herbert Waldmann and Martin Giera and Michael Sundström and Louise Berg and Kilian V. M. Huber}, doi = {10.1002/anie.202420149}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420149}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phenomics-based discovery of novel orthosteric choline kinase inhibitors}, volume = {64}, year = {2025}, }
• (2025). In situ generation of microwire heterojunctions with flexible optical waveguide and hydration-mediated photochromism. ANGEW, 64(7), e202420139. (www)

  @article{ , abstract = {Flexible heterojunctions based on molecular systems are in high demand for applications in photonics, electronics, and smart materials, but fabrication challenges have hindered progress. Herein, we present an in situ approach to creating optical heterojunctions using hydration-mediated flexible molecular crystals. These hydrated multi-component molecular solids display strong blue emitting optical waveguides with minimal optical loss (0.005 dB/μm) and excellent flexibility (elastic modulus: 3.87 GPa). The water-mediated process enables the molecular microwires with tunable elastic and plastic deformation, as well as reversible uptake and release of lattice water, facilitating the formation of flexible heterojunctions. Spectral analysis and theoretical modeling reveal that these microwires exhibit both photochromism and color-tunable dual emission (fluorescence and phosphorescence), expanding their utility in photonic information encoding. Therefore, this work introduces a hydration-mediated molecular engineering strategy for fabricating crystalline heterojunctions with on-demand processability and controllable emission sequences, enabling optical signal manipulation at the micro/nanoscale.}, archive = {J_ANGEW}, author = {Meiqi Dai and Zhenhong Qi and Dongpeng Yan}, doi = {10.1002/anie.202420139}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420139}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ generation of microwire heterojunctions with flexible optical waveguide and hydration-mediated photochromism}, volume = {64}, year = {2025}, }
• (2025). Enhancing mechanical durability and long-term stability in organic solar cells via flexible linker-sequential block copolymerized donors. ANGEW, 64(7), e202420121. (www)

  @article{ , abstract = {Multi-component copolymerized donors ( MCDs ) hold great promise for improving both the efficiency and mechanical robustness of flexible organic solar cells (f-OSCs) owing to their facile molecular tunability and advantageous one-pot copolymerization. However, despite the excellent crystallinity imparted by their highly conjugated polymer backbone, MCDs often struggle to retain photovoltaic performance under large external deformations, limiting their applicability in wearable devices. Herein, we developed a novel series of flexible linker-sequential block MCDs ( Fs-MCDs ), specifically PM6-Cl 0.8 - b -D18-Cl 0.2 -BTB , PM6-Cl 0.8 - b -D18-Cl 0.2 -BTH , and PM6-Cl 0.8 - b -D18-Cl 0.2 -BTD , by precisely incorporating flexible functional groups into the conjugated polymer skeleton. This design strategy introduced highly effective tensile active sites, resulting in remarkable mechanical durability, with PM6-Cl 0.8 - b -D18-Cl 0.2 -BTD achieving crack-onset strain (COS) values of 49.88 % in pristine films and 31.29 % in blends. The nearly 50 % COS in pristine films represents one of the highest values reported for Fs - MCD -based OSCs, marking a significant milestone in advancing f-OSC. Additionally, PM6-Cl 0.8 - b -D18-Cl 0.2 -BTD demonstrated excellent photovoltaic performance, with efficiencies of 18.09 % in rigid binary and 19.05 % in ternary, as well as 16.63 % in flexible OSCs. It also showed impressive device stability in invert OSC ( T 80 =9,078 h). This unique molecular design strategy provides a promising avenue for synergistically improving the photovoltaic performance, mechanical properties, and device stability of f-OSCs.}, archive = {J_ANGEW}, author = {Congqi Lin and Ruixiang Peng and Wei Song and Jiangwei Gao and Tingting Feng and Yongqi Bai and Quan Liu and Mengjin Yang and Jianfeng Zhang and Ziyi Ge}, doi = {10.1002/anie.202420121}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420121}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing mechanical durability and long-term stability in organic solar cells via flexible linker-sequential block copolymerized donors}, volume = {64}, year = {2025}, }
• (2025). Identification of key post-modification enzymes involved in the biosynthesis of lanostane-type triterpenoids in the medicinal mushroom antrodia camphorata.. ANGEW, 64(7), e202420104. (www)

  @article{ , abstract = {Lanostane-type triterpenoids are important bioactive secondary metabolites of mushrooms, though their biosynthetic study has been challenging due to scattered genes. Herein, the strategies of combining metabolomics and transcriptomics analyses, functional motif blast, and KEGG (Kyoto Encyclopedia of Genes and Genomes) annotation were used to discover three key post-modification enzymes involved in the biosynthesis of lanostanoids in the medicinal mushroom Antrodia camphorata . The cytochrome P450 enzyme AcCYP4 could generate a Δ 7,9(11) diene structure and introduce a 15 α -hydroxy group to the triterpene skeleton. The short-chain dehydrogenase AcSDR6 could regio- and stereo- selectively catalyze the dehydrogenation of 3 β -OH to produce 3-keto triterpenoids, and the catalytic mechanisms were interpreted by crystal structure analysis. AcSMT1 could introduce the methyl group at C-24 to produce a unique 31-carbon triterpene skeleton. This work elucidated the major biosynthetic pathway of Antrodia lanostanoids in vitro , and the discovered enzymes could be used to synthesize a series of bioactive triterpenoids.}, archive = {J_ANGEW}, author = {Ya-Qun Zhang and Meng Zhang and Zi-Long Wang and Yang-Oujie Bao and Yu-Qi Wang and Yun-Gang Tian and Lei Ye and Min Ye}, doi = {10.1002/anie.202420104}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Identification of key post-modification enzymes involved in the biosynthesis of lanostane-type triterpenoids in the medicinal mushroom antrodia camphorata.}, volume = {64}, year = {2025}, }
• (2025). Titanium-catalyzed reaction of silacyclobutanes with alkenes: Mimicking the reactivity and reversing the selectivity towards late transition metals. ANGEW, 64(7), e202420092. (www)

  @article{ , abstract = {Transition metal-catalyzed ring opening and expansion reactions of silacyclobutanes (SCBs) constitute an atom- and step-economical strategy to construct value-added silicon-containing chemicals. Despite extensive studies, the reaction of SCBs with simple alkenes has only one precedent. Moreover, most reported reactions of SCBs use late transition metals (Pd, Ni, Rh) as catalysts. By contrast, there are no reports of using early transition metals. Herein, we report the first example, to our knowledge, of early-transition-metal-catalyzed reactions of SCBs using earth's second abundant titanium as a catalyst. Notably, orthogonal selectivity was observed. Selective activation of the relatively inert C(sp 3 )−Si bond was achieved in the case of benzosilacyclobutenes, a selectivity that has rarely been achieved using other metals. Even for silacyclobutanes with C(sp 3 )−Si bonds only, our titanium system also shows complementary selectivity towards late transition metals to give distinct products. Thus, structurally varied SCBs and alkenes were reacted in our system to afford structurally diverse silicon-containing products that are otherwise difficult to obtain using other transition metals.}, archive = {J_ANGEW}, author = {Yaqiong Wang and Jiong Zhang and Fang Wang and Lipeng Wu}, doi = {10.1002/anie.202420092}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Titanium-catalyzed reaction of silacyclobutanes with alkenes: Mimicking the reactivity and reversing the selectivity towards late transition metals}, volume = {64}, year = {2025}, }
• (2025). Benzothiadiazole-fused cyanoindone: A superior building block for designing ultra-narrow bandgap electron acceptor with long-range ordered stacking. ANGEW, 64(7), e202420090. (www)

  @article{ , abstract = {There are great demands of developing ultra-narrow bandgap electron acceptors for multifunctional electronic devices, particularly semi-transparent organic photovoltaics (OPVs) for building-integrated applications. However, current ultra-narrow bandgap materials applied in OPVs, primarily based on electron-rich cores, exhibit defects of high-lying energy levels and inferior performance. We herein proposed a novel strategy by designing the benzothiazole-fused cyanoindone (BTC) unit with ultra-strong electron-withdrawing ability as the terminal to synthesize the acceptor BTC-2. The BTC unit imparts red-shifted absorption up to 1000 nm to BTC-2, attributed to enhanced intramolecular charge transfer and the quinoid resonance effect. Additionally, BTC-2 features deep-lying energy levels with the highest occupied molecular orbital level of −5.81 eV, due to the ultra-strong electron-withdrawing ability of BTC. Furthermore, BTC-2 exhibits long-range ordering in both molecular packing and macroscopic blend morphology, resulting from shoulder-to-shoulder packing of two BTC units, leading to an ultra-long exciton lifetime over 1.1 ns. These superiorities facilitated a 17.17 % efficiency in the binary OPV device with an extremely high photocurrent of 30.34 mA cm −2 , representing the best performance for ultra-narrow bandgap electron acceptors, and a record light utilization efficiency of 4.88 % in binary semi-transparent systems. Overall, BTC is a superior building block for designing ultra-narrow bandgap electron acceptors.}, archive = {J_ANGEW}, author = {Nuo Zhang and Tianyi Chen and Yaokai Li and Shuixing Li and Jinyang Yu and Heng Liu and Mengting Wang and Xiu-Kun Ye and Xueyan Ding and Xinhui Lu and Chang-Zhi Li and Haiming Zhu and Minmin Shi and Hongzheng Chen}, doi = {10.1002/anie.202420090}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420090}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Benzothiadiazole-fused cyanoindone: A superior building block for designing ultra-narrow bandgap electron acceptor with long-range ordered stacking}, volume = {64}, year = {2025}, }
• (2025). Regularly arranged heterogeneous pores in gas separation membranes constructed by cocrystallization of porous organic molecules. ANGEW, 64(7), e202420086. (www)

  @article{ , abstract = {Integrating two or more materials to construct membranes with heterogeneous pore structures is an effective strategy for enhancing separation performance. Regularly arranging these heterogeneous pores can significantly optimize the combined effect of the introduced components. Porous Organic Cages (POCs), an emerging subclass of porous materials composed of discrete molecules, assemble to form interconnected pores and exhibit permanent porosity in the solid state. A unique feature of POCs is their modularity, enabling a “mix and match” approach to create co-crystal structures driven by the intermolecular interactions. Herein, we adopted the cocrystallization strategy for fabricating gas separation membranes. We prepared membranes from a series of [4+6] imine cage pairs, which vary in cavity sizes and include cages with fluorescence properties. By optimizing the cocrystalization conditions, we successfully fabricated continuous, defect-free gas membranes, benefiting from chiral recognition interactions. By introducing regularly alternating small and large pores, we addressed challenges such as the trade-off between permeability and selectivity in gas separation membrane. Moreover, the cocrystallization strategy has been proven effective for other molecular systems besides POCs, such as macrocycles, for the preparation of co-crystal membranes. This method broadens the scope for fabricating high-performance gas separation membranes with ordered heterogeneous pores.}, archive = {J_ANGEW}, author = {Saisai Yu and Siyuan Yang and Miao Yang and Ju Yang and Ziye Song and Dingyue Hu and Heng Ji and Zhe Jia and Ming Liu}, doi = {10.1002/anie.202420086}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420086}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regularly arranged heterogeneous pores in gas separation membranes constructed by cocrystallization of porous organic molecules}, volume = {64}, year = {2025}, }
• (2025). Unusual endotaxy growth of hexagonal nanosheets by the self-assembly of a homopolymer. ANGEW, 64(7), e202420079. (www)

  @article{ , abstract = {A classical crystallization usually grows epitaxially from a crystal nucleus. Presented in this study is an unusual endotaxy growth manner of a crystalline homopolymer to form hexagonal nanosheets. The amphiphilic homopolymer, poly(3-(4-(phenyldiazenyl)phenoxy)propyl methacrylate) (PAzoPMA), is first annealed in isopropanol to afford a hexagonal nut-like structure. Then, the PAzoPMA crystallizes from the inner wall to the center to form a thin bottom, which grows upwards along the bottom, leading to the formation of the evenly hexagonal nanosheets. The energy fluctuation by molecular dynamics (MD) simulation during self-assembly confirms the packing state of PAzoPMA chains in different solvents. In isopropanol, the total energy is the lowest, demonstrating the tight regular arrangement of polymer chains. In addition, the non-bonding interaction energy is also the lowest, leading to the favorable contact with solvent molecules and the formation of hexagonal nanosheets. Otherwise, nanowires and giant large compound micelles are formed in ethanol and n -butanol, respectively. Overall, an unusual endotaxy crystallization manner of an amphiphilic homopolymer is observed during the preparation of hexagonal nanosheets, which brings fresh insight for understanding the crystallization behavior of polymers and preparing functional soft nanomaterials.}, archive = {J_ANGEW}, author = {Chenchen Gao and Hui Sun and Jianzhong Du}, doi = {10.1002/anie.202420079}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420079}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unusual endotaxy growth of hexagonal nanosheets by the self-assembly of a homopolymer}, volume = {64}, year = {2025}, }
• (2025). Efficient near-infrared to blue photon upconversion by ultrafast spin flip and triplet energy transfer at Organic/2D semiconductor interface. ANGEW, 64(7), e202420070. (www)

  @article{ , abstract = {Solid state photon upconversion by triplet-triplet annihilation (TTA), particularly near-infrared (NIR)-to-blue upconversion, holds instant promise for enhancing optoelectronic and photochemical applications. Despite extensive studies, NIR-to-blue upconversion has remained particularly challenging and elusive due to inherent multiple energy-downhill processes in TTA upconversion. In this study, using atomically thin two dimensional (2D) monolayer semiconductor as a triplet sensitizer, we demonstrate an efficient and robust solid-state NIR-to-blue photon upconversion system. The ultrathin and flexible organic/2D bilayer heterostructure exhibits a NIR-to-blue upconversion with high quantum yield (Φ UC =1.2 %, out of 50 %), low threshold power density (I th =110 mW/cm 2 ) and a record-high apparent anti-Stokes shift of 1.12 eV. Further spin- and time-resolved spectroscopy reveals an ultrafast (<500 fs) electron spin flip to triplet-like excitons in semiconductor sensitizer and subsequent picosecond (~6×10 10 s −1 ) interfacial Dexter energy transfer to annihilator molecules. The triplet energy transfer rate and efficiency depend strongly on driving force, exhibiting Marcus normal region behavior. This work demonstrates 2D monolayer semiconductor as a superior ultrathin light harvesting and triplet sensitization layer and reveals the key knob to overcome the compromise between upconversion efficiency and energy loss, offering a viable pathway to efficient solid state NIR-to-blue photon upconversion and implementation.}, archive = {J_ANGEW}, author = {Shuo Zhao and Cheng Sun and Guoyu Xiang and Yongqing Zhang and Siyu He and Shuangshuang Li and Yizheng Jin and Delong Zhang and Haiming Zhu}, doi = {10.1002/anie.202420070}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient near-infrared to blue photon upconversion by ultrafast spin flip and triplet energy transfer at Organic/2D semiconductor interface}, volume = {64}, year = {2025}, }
• (2025). Hydrogen radical enabling industrial-level oxygen electroreduction to hydrogen peroxide. ANGEW, 64(7), e202420063. (www)

  @article{ , abstract = {The electrochemical synthesis of hydrogen peroxide from oxygen and water, powered by renewable electricity, provides a highly attractive alternative to the energy-intensive autoxidation process presently used in industry, but much remains unknown about this two-electron oxygen reduction reaction (2e-ORR), especially the local proton effect. Here, we have investigated the function of hydrogen-associated intermediates in the 2e-ORR using a rationally designed cooperative electrode material with cobalt (II) clusters embedded onto the oxidized carbon nanotube composites (Co-OCNT). We found that the local proton availability can determine both the reaction kinetics and selectivity. A 2e-ORR process involving hydrogen radical transfer is confirmed. Specifically, the carbon sites from the OCNTs promote proton production, and the cobalt sites from the Co cluster facilitate ORR intermediate formation. The high local proton availability and the cooperative dual-active sites both contribute to the superior reaction kinetics and selectivity of the Co-OCNT, reaching an H 2 O 2 production rate of ~40.6 mol g cat −1 h −1 and a faradaic efficiency of 90 % at a current density of 300 mA cm −2 . Further cascading the 2e-ORR with the electro-Fenton process shows a high selectivity of oxalic acid up to 97 % for the valorization of ethylene glycol.}, archive = {J_ANGEW}, author = {Song Xue and Xiaohui Li and Yuanyuan Sun and Wangyang Cui and Fengliang Cao and Zhisheng Cao and Yin Huang and Mingzheng Shao and Zhongtao Li and Linjie Zhi}, doi = {10.1002/anie.202420063}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420063}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen radical enabling industrial-level oxygen electroreduction to hydrogen peroxide}, volume = {64}, year = {2025}, }
• (2025). Molecular-squeeze triggers guest desorption from sponge-like macrocycle crystals. ANGEW, 64(7), e202420048. (www)

  @article{ , abstract = {Desorption in conventional porous sorbents often employ external forces including inert gas blowing, heating, vacuum treatment to trigger guest release. We here report an unprecedented molecular-squeeze triggered guest release behavior from sponge-like macrocycle crystals. The crystals function as typical sponge to include guest molecules within their microscopic voids that are adaptively formed, thus acting as adsorbents for toluene/pyridine separations. Intriguingly, vaporized ethyl acetate ( EA ) molecules trigger the guest release from the crystals without entering the pores or voids of the crystals to replace the guests. Instead, they work as external forces applied directly onto the crystals themselves, ‘‘squeezing” the materials to close the voids through supramolecular interactions between EA and macrocycles on the crystal surface and release the guest molecules. Various experimental techniques as well as molecular dynamics simulations reveal the mechanism of the molecular-squeeze induced guest release procedure. The EA -regenerated crystals can be recycled multiple times without the loss of separation performance. Compared with conventional guest release procedure, this method is manipulated in a mild condition, showing the potential in saving cost and energy.}, archive = {J_ANGEW}, author = {Linnan Zhang and Lifeng Zheng and Yingying Song and Jingwei Huang and Hailong Ning and Leyong Wang and Jing Ma and Kecheng Jie}, doi = {10.1002/anie.202420048}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420048}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular-squeeze triggers guest desorption from sponge-like macrocycle crystals}, volume = {64}, year = {2025}, }
• (2025). Engineering the self-assembly pathways of POSS-peptide amphiphiles to form diverse cross-β structures. ANGEW, 64(7), e202420043. (www)

  @article{ , abstract = {Cross-β structures are crucial in driving protein folding and aggregation. However, due to their strong aggregating tendency, the precise control of the self-assembly of β-sheet-forming peptides remains a challenge. We propose a molecular geometry strategy to study and control the self-assembly of cross-β structures. We conjugate the peptide with shape-persistent polyhedral oligomeric silsesquioxane (POSS), which acts as a hydrophilic head and senses the solvent environment. The POSS-peptide amphiphiles display two distinct self-assembly pathways: twisted nanoribbons transforming into either nanotubes at low water content or flat nanoribbons at high water content. The peptide packing in flat nanoribbons is predominantly modulated by POSS, diverting the system away from crystal formation, which is the absolute lowest energy state of pure peptide self-assemblies. For the first time, we have demonstrated that POSS can serve as a useful tool to adjust the interactions between cross-β strands, achieving fine-tuning of the pathway complexity (i.e., the kinetic and thermodynamic aspects of peptide self-assembly). With this versatile molecular platform incorporating multiple functionalities of POSS and programable peptide sequences, this study provides a platform to exploit cross-β-based nanomaterials with functional and pathological significance.}, archive = {J_ANGEW}, author = {Zhen Du and Junhao Dai and Zhibo Wang and Zushan Ye and Huanyu Lei and Qing-Yun Guo and Xiao-Yun Yan and Mu Li and Minzhao Li and Wangshen Zhao and Beijing Zhang and Yupeng Huang and Ziqiong Yang and Zongwu Huang and Panchao Yin and Lingxiang Jiang and Rui Zhang and Wen Tang}, doi = {10.1002/anie.202420043}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420043}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering the self-assembly pathways of POSS-peptide amphiphiles to form diverse cross-β structures}, volume = {64}, year = {2025}, }
• (2025). Mechanochromic organic micro-laser. ANGEW, 64(7), e202420003. (www)

  @article{ , abstract = {This work presents the first demonstration of a mechanochromic organic micro-laser, which exhibits remarkable wide range pressure sensing characteristics. The gain material, pinacolato boronate ester functionalized anthanthrene (AnBPin), is designed by incorporating mechanofluorochromic (MFC) properties into organic laser dye. The AnBPin exhibits a reversible transition between green and orange fluorescence upon grinding annealing and recrystallization cycle, and its micro-crystal exhibits typical organic micro-laser behaviors. Applying localized mechanical pressure as low as 0.1 MPa inhibits micro-laser behavior at the given spot. In contrast, under 1 to 2 GPa hydrostatic pressure, the organic laser maintains narrow emission while showing a pressure-dependent shift in emission wavelength. By combining theory and experimentation, we attribute the unusual pressure-correlated emission spectroscopy to the unique interleaved locked crystal structure. Understanding the mechanochromic laser behavior in AnBPin micro-crystals under an unprecedented pressure range significantly expands the family of organic micro-lasers and provides a new route for wide-range photonic pressure detection.}, archive = {J_ANGEW}, author = {Chun-Lin Sun and Jun Li and Juan Ye and Yun-Fei Chai and Yun-Tao Ding and Jian-Rong Ma and Lin Wang and Yongjun Tian and Hao-Li Zhang}, doi = {10.1002/anie.202420003}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420003}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanochromic organic micro-laser}, volume = {64}, year = {2025}, }
• (2025). Starfish-inspired solid-state li-ion conductive membrane with balanced rigidity and flexibility for ultrastable lithium metal batteries. ANGEW, 64(7), e202420001. (www)

  @article{ , abstract = {The performance of solid-state lithium-metal batteries (SSLMB) is often constrained by the low ionic conductivity, narrow electrochemical window, and insufficient mechanical strength of polyethylene oxide (PEO)-based electrolytes. Inspired by the soft-outside, rigid-inside structure of starfish, we designed multifunctional “starfish-type” composite polymer electrolytes (CPEs) using electrospinning technology. These CPEs feature a three-dimensional rigid skeleton network composed of polyacrylonitrile/metal–organic frameworks/ionic liquids (PAN/MOFs/ILs), creating continuous and efficient Li + transport channels: MOFs impart rigidity, PEO acts as a cushioning outer layer to enhance interfacial compatibility, and ILs reduce interfacial resistance. The resulting CPEs exhibited excellent ionic conductivity (4.37×10 −4 S cm −1 ), a wide electrochemical window (5.34 V), uniform lithium-ion flux, and a high transference number (0.69). Leveraging these synergistic advantages, the Li/CPEs/Li symmetric cell demonstrated outstanding dendrite suppression for over 1300 hours, and the LiFePO 4 /CPEs/Li cell retained 90.1 % capacity after 2100 cycles at 1.0 C, which is the best performance reported for SSLMB with MOF/PEO. The formation of multi-component solid-electrolyte interphase and its role in stabilizing lithium metal cycling were systematically elucidated through theoretical simulations and spectroscopic analysis. This nature-inspired design provides a promising strategy for the development of stable solid-state electrolytes with extended lifespans.}, archive = {J_ANGEW}, author = {Liequan Liu and Lingfeng Zhu and Youliang Wang and Xinwei Guan and Zhenfang Zhang and Hui Li and Fan Wang and Hai Zhang and Ze Zhang and Zhenyu Yang and Tianyi Ma}, doi = {10.1002/anie.202420001}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202420001}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Starfish-inspired solid-state li-ion conductive membrane with balanced rigidity and flexibility for ultrastable lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Self-assembly and biological properties of highly fluorinated oligonucleotide amphiphiles. ANGEW, 64(7), e202419996. (www)

  @article{ , abstract = {Nucleic acids, used as therapeutics to silence disease-related genes, offer significant advantages over small molecule drugs: they provide high specificity, the ability to target “undruggable” molecules, and adaptability to a wide range of disease phenotypes. However, their instability in biological media, as well their rapid clearance from the organism limit their applicability, necessitating the use of nanocarriers to overcome these challenges. Among these strategies, spherical nucleic acids (SNA)—composed of a densely packed corona of oligonucleotides around a nanoparticle—have emerged as a powerful tool, in particular when self-assembled from DNA amphiphiles. This non-covalent strategy however has caveats, especially when it comes to stability in complex biological media, where these SNAs disassemble in contact to serum proteins. Here, we developed highly fluorinated DNA amphiphiles that readily self-assemble into SNAs and have tunable stability profiles in biological media. They are made of branched fluorinated moieties with potentially improved biodegradability as compared to their linear counterparts. Depending on the number of fluorophilic interactions, the self-assembled SNAs can have excellent serum stabilities—up to days—and readily deliver nucleic acid therapeutics for gene silencing applications. These systems show great potential as promising candidates for nucleic acid-based therapies.}, archive = {J_ANGEW}, author = {Quentin Laurent and Beatrice L. Bona and Jathavan Asohan and Marta Rosati and Sinan Faiad and Francesca Baldelli Bombelli and Pierangelo Metrangolo and Hanadi F. Sleiman}, doi = {10.1002/anie.202419996}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419996}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembly and biological properties of highly fluorinated oligonucleotide amphiphiles}, volume = {64}, year = {2025}, }
• (2025). Stabilizing SPAN in non-flammable acetonitrile electrolytes for long-life Graphite||SPAN batteries. ANGEW, 64(7), e202419995. (www)

  @article{ , abstract = {Sulfurized polyacrylonitrile (SPAN) presents an opportunity to replace elemental sulfur as a “shuttle-free” cathode for secondary Li−S batteries, which can be an ideal choice for stationary energy storage due to its abundance, low cost, and sustainability. The electrolyte options for the state-of-the-art SPAN batteries have been limited to the flammable carbonate and ether ones, which raises safety concerns. Here, we explored the use of a non-flammable acetonitrile (AN) electrolyte for SPAN battery for the first time and identified the irreversible cleavage of C−S bonds of SPAN as the main reason for the failure of SPAN in AN electrolyte. Fortunately, by introducing 10 wt % fluoroethylene carbonate into the AN electrolyte, the bond cleavage in SPAN is suppressed and a stable cathode electrolyte interface is formed, both contributing to stabilizing the structure of SPAN during electrochemical process. Consequently, we achieved a stable cycling for 900 cycles in Li||SPAN cells. Moreover, by pairing with a pre-lithiated graphite (pGr) anode, the newly formulated electrolyte enables extended cycle life for 1500 cycles with a capacity retention of 91 % and superb safety in pGr||SPAN full cell. The present exploitation broadens the electrolyte choices of SPAN-based batteries and paves the way for future applications for these batteries.}, archive = {J_ANGEW}, author = {Yan Li and Xiaoqun Qi and Han Zhou and Fengyi Yang and Xiaoyu Jin and Ruining Jiang and Zhenglu Zhu and Chaofan Liang and Zhen Li and Lixia Yuan and Long Qie and Yunhui Huang}, doi = {10.1002/anie.202419995}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419995}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilizing SPAN in non-flammable acetonitrile electrolytes for long-life Graphite||SPAN batteries}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of (−)-cordycicadin d and 3,4-trans-cordycicadins a and b: Entry to the 3,4-trans-fused cordycicadin framework. ANGEW, 64(7), e202419989. (www)

  @article{ , abstract = {Cordycicadins A−D are four C 20 polyketides, all containing a γ-lactone fused to a 10-membered lactone. The proposed biosynthetic pathway for the cordycicadins anticipates the formation of two more natural products which are unknown. We report the total synthesis of (–)-cordycicadin D and the two anticipated natural products 3,4- trans -cordycicadins A and B. The targets were convergently assembled, in a biomimetic fashion, via an efficient ketene trapping-intramolecular Michael addition sequence that delivered the requisite 3,4- trans -fused framework with high diastereoselectivity, enabled by the synthesis of complex dioxenones that serve as in situ ketene precursors. Recognition of the embedded polyketide symmetry enabled the use of a divergent-convergent synthetic strategy, based on the use of two products from an early-stage enzymatic resolution. The synthetic routes afforded (–)-cordycicadin D in 14 steps and 3,4- trans -cordycicadins A and B in 13 steps (longest linear sequence). This work confirms the structure of (−)-cordycicadin D and the observed instability of the anticipated natural product 3,4- trans -cordycicadin B during purification may explain why it is yet to be isolated.}, archive = {J_ANGEW}, author = {Liam R. Hunt and Phillip S. Grant and Grace K. Shimokura and Daniel P. Furkert and Margaret A. Brimble}, doi = {10.1002/anie.202419989}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419989}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of (−)-cordycicadin d and 3,4-trans-cordycicadins a and b: Entry to the 3,4-trans-fused cordycicadin framework}, volume = {64}, year = {2025}, }
• (2025). Two-electron oxidative atom and group transfer reactions at a well-defined Uranium(II) center. ANGEW, 64(7), e202419987. (www)

  @article{ , abstract = {The multi-electron redox chemistry of uranium(II) compounds remains largely unexplored. Herein, we report a series of two-electron oxidative atom and group transfer reactions at a well-defined uranium(II) center. The reactions of uranium(II) complexes [M][( Ad TPBN 3 )U] (M=K(2,2,2-cryptand) and K(18-crown-6)(THF)) with pyridine- N -oxide or nitrosobenzene, elemental sulfur/selenium or triphenylphosphine sulfide/selenide, and ditellurium salt led to the isolation of uranium(IV) terminal oxo and chalcogenido complexes [M][( Ad TPBN 3 )UX] (X=O, S, Se, Te). In addition, the reactions of [M][( Ad TPBN 3 )U] with aryl azides ArN 3 or diazoalkanes R 2 CN 2 quantitatively yielded uranium(IV) terminal imido [M][( Ad TPBN 3 )UNAr] or hydrazonido(2−) complexes [M][( Ad TPBN 3 )UN 2 CR 2 ], respectively. Notably, the low-temperature reaction between [M][( Ad TPBN 3 )U] and mesityl azide allowed the isolation of the first uranium(IV) aryldiazenylimido complex as an intermediate. These uranium(IV)−element multiply bound compounds were fully characterized by X-ray crystallography, 1 H NMR spectroscopy, absorption spectroscopy, solution and solid-state magnetometry, and elemental analysis. The controlled two-electron oxidative reactions at a uranium(II) center not only expand the redox reactivity of uranium(II) but also offer a convenient new route to access uranium−element multiply bound compounds.}, archive = {J_ANGEW}, author = {Chong Deng and Yilun Li and Yi Wang and Wenliang Huang}, doi = {10.1002/anie.202419987}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419987}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-electron oxidative atom and group transfer reactions at a well-defined Uranium(II) center}, volume = {64}, year = {2025}, }
• (2025). Single solid-state emissive carbon quantum dots for multicolor, bright and efficient electroluminescent light-emitting diodes. ANGEW, 64(7), e202419983. (www)

  @article{ , abstract = {Color-tunable electroluminescent light-emitting diodes (LEDs) based on quantum dots (QDs) are rapidly emerging as a key technology for next-generation full-color displays and solid-state lighting. However, achieving broad color tunability in LEDs that utilize a single QD emissive material continues to pose significant challenges. Here, we present the first example of bright, multicolor electroluminescent LEDs with tunable emission peaks spanning from 535 to 640 nm, utilizing a new type of single red solid-state emissive carbon quantum dots (R-SSCQDs). Unlike conventional CQDs, which often exhibit weak or negligible emission in solid-state form, R-SSCQDs demonstrate bright red emission in solid state and green emission in diluted state. Experimental investigations and theoretical calculations reveal that the unique non-planar spatial structure and significant steric hindrance of R-SSCQDs effectively suppress π–π stacking, resulting in efficient solid-state fluorescence emission. By adjusting the weight ratios of R-SSCQDs doped in host materials, we showcase bright, efficient and multicolor CQD-based LEDs that emit green, yellow, orange, and red light, achieving a record-high luminance of 15,834 cd m −2 and current efficiency of 10.3 cd A −1 . This work presents a straightforward and universal strategy for creating efficient solid-state emissive CQDs, showcasing significant potential for color-tunable LED applications.}, archive = {J_ANGEW}, author = {Chenhao Li and Jinyang Li and Qian Teng and Jinsui Li and Fanglong Yuan}, doi = {10.1002/anie.202419983}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419983}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single solid-state emissive carbon quantum dots for multicolor, bright and efficient electroluminescent light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Polyglycidamides: From backbone-promoted amidation to degradable polyether with wide-range LCST. ANGEW, 64(7), e202419978. (www)

  @article{ , abstract = {Amide groups occur extensively in natural and synthetic polymers cultivating their vital roles in biological and industrial worlds. We report here an efficient and controlled pathway to amide-functionalized polyethers through ring-opening polymerization (ROP) of commercially available ethyl glycidate followed by amidation of the pendant ester groups. Transesterification is inhibited during the ROP by use of a two-component organocatalyst. Surprisingly, amidation can be completed even at 0 °C uncatalyzed, which is attributed to the electron-withdrawing effect of the oxygenated backbone as well as the inter-/intra-chain hydrogen bonding. Also interestingly, ethylene glycol and water are found to further accelerate the amidation while suppressing backbone degradation. The obtained polyglycidamides (PGAms) exhibit aqueous thermoresponsive properties, similar to their carbon-chain counterparts (polyacrylamides). Cloud point can be linearly modulated by co-amidation using two amines of varied ratios. Unlike polyacrylamides and regular polyethers, PGAm is degradable through retro-oxa-Michael addition under basic conditions.}, archive = {J_ANGEW}, author = {Xingpei Hong and Shan Liu and Jie Pang and Junpeng Zhao and Guangzhao Zhang}, doi = {10.1002/anie.202419978}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyglycidamides: From backbone-promoted amidation to degradable polyether with wide-range LCST}, volume = {64}, year = {2025}, }
• (2025). A de novo auto-activated solar-driven biohybrid system for hydrogen production in methanotrophic cells. ANGEW, 64(7), e202419973. (www)

  @article{ , abstract = {Climate change driving by greenhouse gas emissions from petroleum-based energy has garnered significant attention. Renewable energy production via a sustainable system that integrates the cell factory and visible-light-driven photocatalysts offers a novel approach for upcycling methane and addressing global energy challenges. Here, an auto-activated biohybrid system driven by solar energy is developed for converting methane into hydrogen fuel, which incorporated thienoviologen (S-MV 2+ ) and genetically engineered methanotrophic bacteria. In this system, S-MV 2+ functioned as photosensitizer and electron mediator, capturing solar energy and supplying electrons for an enzyme-catalyzed bioprocess. The genetically modified Methylomicrobium buryatense 5GB1 mutant, lacking methanol dehydrogenase but overexpressing hydrogenase, is able to convert methane into methanol that maintains the electron flow cycle by quenching photogenerated holes for both hydrogen biosynthesis and methane oxidation. Finally, the highest H 2 production of 272.96 μM from this biohybrid system was achieved with methanol as a sacrificial agent generated by the H 2 -producing mutant, resulting in a 140-fold enhancement. This innovative method showcases the potential of coupling photocatalysis with methanotrophic biocatalysis for sustainable energy production. Additionally, the system introduces a new strategy for self-regeneration of sacrificial agents, offering a promising avenue for hydrogen production using greenhouse gases in an eco-friendly manner.}, archive = {J_ANGEW}, author = {Ziyue Jiao and Guoping Li and Shuqi Guo and Weiting Wang and Qianzi Hou and Yawen Li and Wenqiang Ma and Gang He and Qiang Fei}, doi = {10.1002/anie.202419973}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A de novo auto-activated solar-driven biohybrid system for hydrogen production in methanotrophic cells}, volume = {64}, year = {2025}, }
• (2025). Organic crosslinked tin oxide mitigating buried interface defects for efficient and stable perovskite solar cells. ANGEW, 64(7), e202419957. (www)

  @article{ , abstract = {Tin dioxide (SnO 2 ) stands as a promising material for the electron transport layer (ETL) in perovskite solar cells (PSCs) attributed to its superlative optoelectronic properties. The attainment of superior power conversion efficiency hinges critically on the preparation of high-quality SnO 2 thin films. However, conventional nanoparticle SnO 2 colloids often suffer from inherent issues such as numerous oxygen vacancy defects and film non-uniformity. In this study, we report a strategy to homogenize SnO 2 with reduced defects for high-performance PSCs. The commercial SnO 2 colloid is modulated with bisphenol S (BPS) crosslinking to achieve a better annealing intermediate state. The phenolic hydroxyl groups on BPS bond with the hydroxyl groups on the SnO 2 surface, passivating defects as well as promoting superb regularity of the films by forming a network of the SnO 2 nanoparticles. Additionally, the sulfone groups on BPS coordinate with Pb 2+ , regulating the crystallization of PbI 2 and FAPbI 3 , which leads to better interface contact at the buried interface. The FAPbI 3 perovskite solar cells based on BPS-crosslinked SnO 2 layers achieved a champion efficiency of 24.87 % and retained 95 % of their initial PCE after 1000 hours of continuous light soaking under N 2 atmosphere.}, archive = {J_ANGEW}, author = {Jiang He and Jiyao Zhang and Yong Zhang and Jiamin Xu and Zheng Liang and Peide Zhu and Wenbo Peng and Geping Qu and Xu Pan and Xingzhu Wang and Baomin Xu}, doi = {10.1002/anie.202419957}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419957}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic crosslinked tin oxide mitigating buried interface defects for efficient and stable perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). IrPdCuFeNiCoMo based core-shell icosahedron nanocrystals and nanocages for efficient and robust acidic oxygen evolution. ANGEW, 64(7), e202419956. (www)

  @article{ , abstract = {Facets engineering of high entropy alloy (HEA) nanocrystals might be achieved via shape-controlled synthesis, which is promising but remains challenging in designing Ir-based catalysts towards efficient and robust oxygen evolution reaction (OER) in acidic medium. Herein, icosahedra nanocrystals featured with PdCu core and IrPdCuFeNiCoMo shell were prepared by wet-chemical reduction in one-pot, ascribing to the initial formation PdCu core and subsequent deposition and diffusion of IrPdCuFeNiCoMo HEA shell. Sequential selective chemical etching of PdCu core results in IrPdCuFeNiCoMo HEA nanocages, delivering an overpotential of 235 mV at 10 mA cm −2 , 51.0 mV dec −1 , and 1624 A g Ir −1 at 1.50 V vs reversible hydrogen electrode in a conventional three electrode cell. In a proton exchange membrane water electrolyzer, it delivers a low cell voltage of 1.65 and 1.77 V at a current density of 1.0 and 2.0 A cm −2 , respectively, and maintains stable over 900 h at 500 mA cm −2 . Theoretical calculations attribute the enhanced intrinsic activity to the broad distribution of the binding energy for OER intermediates on IrPdCuFeNiCoMo HEA, which breaks the linear scaling relationship and accelerates the OER process.}, archive = {J_ANGEW}, author = {Mairui Long and Siyuan Lai and Kanghua Miao and Wendan Jiang and Wei Fan and Xiongwu Kang}, doi = {10.1002/anie.202419956}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419956}, shortjournal = {Angew. Chem. Int. Edit.}, title = {IrPdCuFeNiCoMo based core-shell icosahedron nanocrystals and nanocages for efficient and robust acidic oxygen evolution}, volume = {64}, year = {2025}, }
• (2025). Rhodium-catalyzed meta-C−H arylation of arenes with varied linker lengths: Bridging catalytic selectivity with structural diversity. ANGEW, 64(7), e202419954. (www)

  @article{ , abstract = {The directing group (DG)-assisted approach has so far been the major route to achieve selective C−H activation at both proximal and distal positions. While rhodium catalysts are highly effective in DG-assisted ortho -C−H arylation, meta- C−H arylation with rhodium has not yet been reported. In this study, we present the first example of Rh-catalyzed meta- C−H arylation of arenes. We found that the 2-cyanophenyl-based directing group, in conjunction with arylboronic acids, selectively promotes meta -arylation with complete mono-selectivity. Despite significant advancements in meta -C−H activation for substrates with shorter linkers, such as hydrocinnamic acids, benzyl alcohols/amines, etc ., meta -C−H activation of substrates with longer alkyl chains remains challenging with limited literature examples. We demonstrated that arenes with varying chain lengths, including conformationally flexible and less rigid ones such as 4-phenylbutanoic acid, 5-phenylvaleric acid, 6-phenylcaproic acid, 3-phenylpropanol, and 4-phenylbutanol underwent meta -arylation with high levels of regiocontrol. From a synthetic perspective, this approach could be valuable as it allows to produce biaryl derivatives of flexible arenes with native functional groups at the meta -position. The synthetic utility of this strategy is demonstrated through the total synthesis of CNBCA, a bioactive compound possessing promising potency against the SHP2 enzyme activity in vitro.}, archive = {J_ANGEW}, author = {Astam Mandal and Jyoti Prasad Biswas and Debabrata Maiti}, doi = {10.1002/anie.202419954}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419954}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rhodium-catalyzed meta-C−H arylation of arenes with varied linker lengths: Bridging catalytic selectivity with structural diversity}, volume = {64}, year = {2025}, }
• (2025). Vacuum-assisted confined growth of MOF@COF composite membranes with enhanced hydrogen permselectivity. ANGEW, 64(7), e202419946. (www)

  @article{ , abstract = {With ordered and periodic network structures, adjustable pore sizes and high chemical stability, covalent organic frameworks (COFs) have drawn much attention for the fabrication of superior separation membranes. However, it is challenging to prepare COF membranes with a molecular sieving property for gas separation due to their relatively large pore size. In this work, we develop the MOF-in-COF concept for vacuum-assisted synthesis of metal–organic framework (MOF) ZIF-8 inside the pores of TB-COF formed from trihydroxy-benzene-tricarbaldehyde (T) and diamino-biphenyl-disulfonic acid (B), thus constructing a novel ZIF-8@TB-COF membrane. Attributing to the formation of a well-defined one-dimensional (1D) nanoscale transport channel, the ZIF-8@TB-COF membrane displays a high hydrogen permselectivity. At 100 °C and 200 kPa, the mixture separation factors of H 2 /CO 2 , H 2 /CH 4 and H 2 /C 3 H 8 are 21.9, 63.1 and 134.4, respectively, which are much higher than those of the pristine TB-COF membrane due to the precise size sieving channels brought about by the incorporated MOF. The synthesis of ZIF-67@TB-COF membrane demonstrates the versatility of the synthesis strategy.}, archive = {J_ANGEW}, author = {Siqi Li and Zheng Wan and Chunxin Jin and Jinlin Hao and Yanhong Li and Xiaofang Chen and Jürgen Caro and Aisheng Huang}, doi = {10.1002/anie.202419946}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419946}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vacuum-assisted confined growth of MOF@COF composite membranes with enhanced hydrogen permselectivity}, volume = {64}, year = {2025}, }
• (2025). Intracellular co-delivery of carbon monoxide and nitric oxide induces mitochondrial apoptosis for cancer therapy. ANGEW, 64(7), e202419939. (www)

  @article{ , abstract = {Understanding the interplay between gasotransmitters is essential for unlocking their therapeutic potential. However, achieving spatiotemporally controlled co-delivery to target cells remains a significant challenge. Herein, we propose an innovative strategy for the intracellular co-delivery of carbon monoxide (CO) and nitric oxide (NO) gasotransmitters under clinically relevant wavelengths. This approach rationally couples aerobic photooxidative and anaerobic photocatalytic reactions within a polymeric micelle platform, using palladium(II) tetraphenyltetrabenzoporphyrin (PdTPTBP) as both photosensitizer and photocatalyst. Notably, the photooxidation-mediated release of CO generates a local hypoxic microenvironment, which facilitates the photoredox catalyzed release of NO. This self-adaptive micelle platform enables efficient uptake by tumor cells and intracellular co-delivery of CO and NO under 630 nm light irradiation, demonstrating potent anti-tumor activity in a 4T1 tumor-bearing mouse model via the synergistic induction of mitochondrial apoptosis.}, archive = {J_ANGEW}, author = {Zhiqiang Shen and Wei Jiang and Shaoqiu Zheng and Siyuan Luo and Zixuan Guo and Qin Wang and Yucai Wang and Jinming Hu}, doi = {10.1002/anie.202419939}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419939}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intracellular co-delivery of carbon monoxide and nitric oxide induces mitochondrial apoptosis for cancer therapy}, volume = {64}, year = {2025}, }
• (2025). H induced metal-insulation transition boosts the stability of high temperature polymer electrolyte membrane fuel cells. ANGEW, 64(7), e202419919. (www)

  @article{ , abstract = {High temperature polymer electrolyte membrane fuel cells (HT-PEMFCs) have garnered significant attention due to their expanded range of hydrogen sources and simplified management systems. However, the frequent start-up and shut-down (SU/SD) caused fuel starvation operation condition seriously deteriorates the performance and lifetime of the fuel cell. In this manuscript, VO 2 was incorporated in the anode to restrain fuel starvation of the electrode. Under the operation condition, the insulative VO 2 would reversibly transform into metallic H x VO 2 by intercalating hydrogen, and H x VO 2 can automatically release hydrogen, which could act as the hydrogen buffer and suppress reverse-current degradation. After the hydrogen release, the generated insulating VO 2 would prevent the side reactions during fuel starvation. Compared to the traditional Pt anode, the electrode with VO 2 showed much higher output power and greatly improved durability after fuel starvation. This work demonstrates the in situ reversible hydrogen storage/release-controlled metal-insulator phase transition strategy to enhance the durability of fuel cells.}, archive = {J_ANGEW}, author = {Liguang Lin and Zhiwei Cai and Yuanfei Niu and Yujie Wu and Jingjing Wang and Miaoyu Li and Dong Li and Tehua Wang and Zhengbang Wang and Li Tao and Shuangyin Wang}, doi = {10.1002/anie.202419919}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419919}, shortjournal = {Angew. Chem. Int. Edit.}, title = {H induced metal-insulation transition boosts the stability of high temperature polymer electrolyte membrane fuel cells}, volume = {64}, year = {2025}, }
• (2025). Highly enantioselective transportation across liquid membranes mediated by porous covalent organic frameworks. ANGEW, 64(7), e202419916. (www)

  @article{ , abstract = {Chiral liquid membrane separation is crucial in pharmaceuticals and chemical synthesis for its simplicity and stability, yet designing membrane carriers that enable efficient enantioseparation remains a challenge. Here, we demonstrated for the first time that chiral porous materials can act as mobile carriers of bulk liquid membranes (BLMs) to enhance enantioselective transport and separation. We design and prepare three 2D chiral covalent organic frameworks (CCOFs) by imine condensations of a chiral dialdehyde with triamines containing ethyl, fluorine and/or isopropyl groups. These isostructural CCOFs feature ABC stacking, excellent water, acid and base tolerance, and chiral amine groups in 1D porous channels, promoting efficient enantioselective transportation of amino acid enantiomers. Among them, the CCOF with both -F and - i Pr groups showing superior transport performance. Exfoliating the CCOF into chiral nanosheets creates flexible layers with accessible active sites, enabling nanosheet-mediated liquid membranes to separate chiral drug enantiomers, a feat unattainable with the pristine CCOF. This work establishes CCOFs as a promising platform for chiral BLM separations and will guide the design of high-performance BLMs using porous materials for enantioselective separation.}, archive = {J_ANGEW}, author = {Xiaofeng Zhang and Bang Hou and Ziping Li and Shiguo Fu and Shuo Liu and Lei Jia and Yan Liu and Yong Cui}, doi = {10.1002/anie.202419916}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly enantioselective transportation across liquid membranes mediated by porous covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Engineering of HO−Zn−N2 active sites in zeolitic imidazolate frameworks for enhanced (Photo)Electrocatalytic hydrogen evolution. ANGEW, 64(7), e202419913. (www)

  @article{ , abstract = {Currently, lack of ways to engineer specific and well-defined active sites in zeolitic imidazolate frameworks (ZIFs) limits our fundamental knowledge with respect to the mechanistic details for (photo)electrocatalytic hydrogen evolution reaction (HER). Here, we introduce the open metal sites into ZIFs through the selective ligand removal (SeLiRe) strategy, comprehensively characterize the altered structural and electronic features, and evaluate their role in HER. In situ electrochemical analysis and X-ray absorption spectroscopy reveal the formation of high-valence HO−Zn−N 2 sites through the binding of Zn−N 2 with electrolyte hydroxide. The optimal OMS-ZIF exhibits a low overpotential of 0.41 V to achieve an ampere-level 1.0 A cm −2 with 120-hour stability. Theoretical simulations indicate that these active sites accelerate the water molecules activation kinetics, consequently enhancing the efficiency of the Volmer step. This work demonstrates a versatile strategy to introduce highly active catalytic sites in ZIFs, providing new insights into the electrocatalytic mechanism in alkaline media.}, archive = {J_ANGEW}, author = {Zheao Huang and Zhouzhou Wang and Qiancheng Zhou and Hannah Rabl and Shaghayegh Naghdi and Ze Yang and Dominik Eder}, doi = {10.1002/anie.202419913}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering of HO−Zn−N2 active sites in zeolitic imidazolate frameworks for enhanced (Photo)Electrocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Enhanced quantum efficiency via co-substitution in red-emitting phosphor Sr2[MgAl5N7]: Eu2+ for advanced spectroscopic applications including laser displays with ultra-high luminescence saturation threshold. ANGEW, 64(7), e202419910. (www)

  @article{ , abstract = {In order to obtain novel and more efficient red light-emitting materials, a series of Sr 2 [Mg 1−x Li x Al 5−x Si x N 7 ] : 0.01Eu 2+ (SMAN-xLS, 0≤x≤0.5) red phosphors were devised and successfully synthesized via the high temperature solid state reaction and the effects of the co-substitution of [Mg−Al] 5+ by [Li−Si] 5+ on structural and luminescence properties is investigated in detail. A series of powder XRD data and Rietveld refinement indicate that [Li−Si] 5+ co-substitution can successfully enter the Sr 2 [MgAl 5 N 7 ] : 0.01Eu 2+ (SMAN) lattice. With the entry of [Li−Si] 5+ into the lattice, the substitution of Al 3+ by Si 4+ leads to the weakening of the nephelauxetic effect of the 5d level of Eu 2+ , which shifts the emission peak from 657 nm to 647 nm and reduces the excitation in the green region, i.e., lowers the absorption of green light. When the amount of [Li−Si] 5+ co-substitution is x =0.1, the luminescence intensity and thermal stability of the sample are enhanced, in which the external quantum efficiency (EQE), reflecting the luminescence intensity, is elevated by 49.6 %. The increase in lattice rigidity gives rise to higher luminescence intensity, and the introduced trap levels for the compensation of luminescence enhances the thermal stability. Under blue laser excitation, the SMAN-0.1LS can achieve an ultra-high luminescence saturation threshold of 52.22 W/mm 2 , which is remarkably superior to other existing red phosphors, a breakthrough performance that has enormous potential for application in high-power laser display light sources. Cathodoluminescence (CL) characterization and measurements attest to the favorable CL properties of SMAN-0.1LS. By measuring the pressure-dependent luminescence of SMAN-0.1LS, the emission peak can be shifted from 650 nm to 702 nm with the increase of pressure, and the sensitivity dλ/dP is 5.07 nm/GPa, which is indicative of the potential application of this system as an optical pressure sensor.}, archive = {J_ANGEW}, author = {Zebin Li and Haoyang Wang and Zhezhe Su and Runtian Kang and Takatoshi Seto and Yuhua Wang}, doi = {10.1002/anie.202419910}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419910}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced quantum efficiency via co-substitution in red-emitting phosphor Sr2[MgAl5N7]: Eu2+ for advanced spectroscopic applications including laser displays with ultra-high luminescence saturation threshold}, volume = {64}, year = {2025}, }
• (2025). Depth-of-discharge dependent capacity decay induced by the accumulation of oxidized lattice oxygen in li-rich layered oxide cathode. ANGEW, 64(7), e202419909. (www)

  @article{ , abstract = {More and more basic practical application scenarios have been gradually ignored/disregarded, in fundamental research on rechargeable batteries, e.g. assessing cycle life under various depths-of-discharge (DODs). Herein, although benefit from the additional energy density introduced by anionic redox, we critically revealed that lithium-rich layered oxide (LRLO) cathodes present anomalously poor capacity retention at low-DOD cycling, which is essentially different from typical layered cathodes (e.g. NCM), and pose a formidable impediment to the practical application of LRLO. We systemically demonstrated that DOD-dependent capacity decay is induced by the anionic redox and accumulation of oxidized lattice oxygen (O n− ). Upon low-DOD cycling, the accumulation of O n− and the persistent presence of vacancies in the transition metal (TM) layer intensified the in-plane migration of TM, exacerbating the expansion of vacancy clusters, which further facilitated detrimental out-of-plane TM migration. As a result, the aggravated structural degradation of LRLO at low-DOD impeded reversible Li + intercalation, resulting in rapid capacity decay. Furthermore, prolonged accumulation of O n− persistently corroded the electrode-electrolyte interface, especially negative for pouch-type full-cells with the shuttle effect. Once the “double-edged sword” effect of anionic redox being elucidated under practical condition, corresponding modification strategies/routes would become distinct for accelerating the practical application of LRLO.}, archive = {J_ANGEW}, author = {Kang Zhang and Yilong Chen and Yuanlong Zhu and Qizheng Zheng and Yonglin Tang and Dongyan Yu and Qirui Liu and Haiyan Luo and Jianhua Yin and Linhui Zeng and Wen Jiao and Na Liu and Qingsong Wang and Lirong Zheng and Jing Zhang and Yongchen Wang and Baodan Zhang and Yawen Yan and Huan Huang and Chong-Heng Shen and Yu Qiao and Shi-Gang Sun}, doi = {10.1002/anie.202419909}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419909}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Depth-of-discharge dependent capacity decay induced by the accumulation of oxidized lattice oxygen in li-rich layered oxide cathode}, volume = {64}, year = {2025}, }
• (2025). Small-molecule benzo-phenoselenazine derivatives for multi-subcellular biomolecule profiling. ANGEW, 64(7), e202419904. (www)

  @article{ , abstract = {Elucidating the subcellular localization of RNAs and proteins is fundamental to understanding their biological functions. Genetically encoded proteins/enzymes provide an attractive approach to target many proteins of interest, but are limited to specific cell lines. Although small-molecule-based methods have been explored, a comprehensive system for profiling multiple locations in living cells, comparable to fusion-protein techniques, is yet to be established. In this study, we introduce a novel proximity labeling strategy employing a suite of small molecules derived from benzo-phenoselenazine (e.g., selenium-containing Nile Blue [SeNB]), which achieves proximity labeling through singlet oxygen generation upon near-infrared light activation in the presence of propargylamine. These SeNB compounds allow for selective labeling of RNAs and proteins within living cells, exhibiting a distinct preference for organelle membranes, which are systematically investigated via in vitro , computational, and in cellulo examinations. Our findings highlight the capabilities of SeNB derivatives as wash-free and genetics-free approaches to illuminate the subcellular localization of biological molecules with deep penetration and high spatial resolution. Moreover, SeNB derivatives are capable of elucidating inter-organelle interactions at the molecular level, as evidenced by proteomic and transcriptomic analyses, thus holding significant potential for advancing our understanding of cellular processes related to disease progression and therapeutic development.}, archive = {J_ANGEW}, author = {Han Jia and Jinghua Han and Yajing Qi and Jie Liu and Yuen Ting Leung and Yau Hei Tung and Yuanyuan Chu and Tong Wang and Yi-Man Eva Fung and Yi Wang and Ying Li}, doi = {10.1002/anie.202419904}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419904}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Small-molecule benzo-phenoselenazine derivatives for multi-subcellular biomolecule profiling}, volume = {64}, year = {2025}, }
• (2025). Restraining planar gliding in single-crystalline LiNi0.9Co0.05Mn0.05O2 cathodes by combining bulk and surface modification strategies. ANGEW, 64(7), e202419903. (www)

  @article{ , abstract = {The delamination cracking from planar gliding along the (003) facets and anisotropic lattice strain perpendicular to the (003) facets inevitable lead to degradation of Ni-rich single-crystal cathode materials, adversely affecting their cyclability. Herein, we rationally design a single-crystal LiNi 0.9 Co 0.05 Mn 0.05 O 2 (SC90) cathode with robust chemo-mechanical properties, in which coherently grown MgO 6 octahedra and BO 4 tetrahedra are incorporated into the lattice, and a stabilizing Mg 3 (BO 3 ) 2 layer is concurrently formed on the particle surface. Multiscale in /ex situ characterizations and theoretical calculations indicate that introducing the MgO 6 and BO 4 units leads to a “pinning effect” within the layered structure. This in turn strongly mitigates mechanical degradation by reducing planar gliding and delamination cracking over extended cycling. Moreover, the Mg 3 (BO 3 ) 2 coating maintains fast lithium diffusion by suppressing parasitic reactions at the cathode|electrolyte interface. The tailored SC90 cathode exhibits a capacity retention of ~88 % after 300 cycles at 5 C rate, significantly outperforming the pristine counterpart (~60 %). Additionally, a pouch-type full cell with a graphite anode sustains a specific discharge capacity of 177 mAh g −1 after 500 cycles, with 90 % capacity retention. This work highlights the “pining effect” in preventing unfavorable slab sliding and structural deterioration, offering new insights for designing advanced ultrahigh Ni single-crystal cathodes.}, archive = {J_ANGEW}, author = {Zhouliang Tan and Xiaoxuan Chen and Jing Lin and Yudai Huang and Wenhua Cheng and Qingcui Liu and Han Zhang and Fucheng Ren and Yingde Huang and Zhenjie Liu and Torsten Brezesinski and Yong Yang and Wengao Zhao}, doi = {10.1002/anie.202419903}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419903}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Restraining planar gliding in single-crystalline LiNi0.9Co0.05Mn0.05O2 cathodes by combining bulk and surface modification strategies}, volume = {64}, year = {2025}, }
• (2025). Reactive intermediate confinement in beta zeolites for the efficient aerobic epoxidation of α-olefins. ANGEW, 64(7), e202419900. (www)

  @article{ , abstract = {The efficient conversion of long-chain linear α-olefins (LAOs) into industrially useful epoxides is of pivotal importance. Mukaiyama epoxidation based on the use of molecular oxygen as the sole oxidant and aldehyde as the cosubstrate offers a promising route for LAOs epoxidation. However, challenges associated with epoxide forming selectivity and aldehyde coupling efficiency have long impeded the adoption of Mukaiyama epoxidation in large-scale applications. Herein, we show that confinement of key intermediates involved in the parallel epoxidation pathways within a Beta zeolite unlocks a selectivity of greater than 95 % towards the epoxides at the expense of minimal consumption of only 1.5 equivalents of the aldehyde, achieving an efficiency better than the state-of-the-art homogeneous and heterogeneous catalysts. Moreover, the incorporation of Sn sites into the Beta zeolite framework further facilitates the adsorption activation process of the aldehyde cosubstrate, thereby increasing the concentration of acylperoxy radicals and accelerating the kinetic process of the epoxidation step. Consequently, this work not only provides an efficient and green epoxidation route over zeolite catalysts with easily available O 2 as the oxidant, but also systematically reveals the fundamental understanding of the zeolite confinement effects on steering the reaction pathway, which benefits the further development of valorization of LAOs.}, archive = {J_ANGEW}, author = {Ziyu Zhou and Kun Zhang and Peng He and Hongying Chang and Min Zhang and Tao Yan and Xiangjie Zhang and Yongwang Li and Zhi Cao}, doi = {10.1002/anie.202419900}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419900}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reactive intermediate confinement in beta zeolites for the efficient aerobic epoxidation of α-olefins}, volume = {64}, year = {2025}, }
• (2025). Heptannulated perylene diimides: Formation and reactivity of electron-deficient tropylium cations and heptafulvenes. ANGEW, 64(7), e202419899. (www)

  @article{ , abstract = {The development of new π-conjugated motifs opens pathways to previously unexplored classes of organic semiconductors and functional dyes. In this study, five- and seven-membered carbocycles were fused at the ortho and bay regions of electron-deficient perylenes, starting from a common dialdehyde precursor. Structural analysis of the resulting perylene tetraesters, dianhydrides, and diimides (PDIs) revealed three distinct ring-fusion patterns and defined stereochemistry. The fused PDI cycloheptatrienes demonstrated susceptibility to acid-catalyzed transarylation, involving tropylium cation intermediates, which can be used preparatively. Under superacidic conditions, the PDI tropylium cations were directly observed and shown to undergo hydride-transfer reductions. Additionally, a fused PDI bis(heptafulvene) was synthesized by dehydrogenating a suitably substituted PDI cycloheptatriene. The final system contains two quinomethane units, which can be protonated to yield a stable tropylium-like dication.}, archive = {J_ANGEW}, author = {Agata Wiencierz and Tadeusz Lis and Piotr J. Chmielewski and Joanna Cybińska and Marcin Stępień}, doi = {10.1002/anie.202419899}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419899}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heptannulated perylene diimides: Formation and reactivity of electron-deficient tropylium cations and heptafulvenes}, volume = {64}, year = {2025}, }
• (2025). Skeletal rearrangement of azo compounds enables low-potential, high-capacity organic anodes for rechargeable alkaline batteries. ANGEW, 64(7), e202419887. (www)

  @article{ , abstract = {The widespread adoption of rechargeable alkaline batteries is plagued by the performance-limiting metal anodes, which are prone to (electro)chemical corrosion and raise environmental or economic concerns. Organic redox-active materials offer a potential solution, but they typically struggle with dissolution-induced degradation and insufficiently negative reduction potentials. Herein, we introduce benzo[c]cinnoline and its derivatives (collectively referred to as BCCs), a class of aromatic azo compounds with fused-ring structure, as promising organic anode materials. BCCs exhibit pronounced aromaticity and Brønsted basicity, conferring low reduction potentials and intrinsic insolubility in alkaline solutions. Paired with the industrially established nickel hydroxide cathode, these batteries deliver excellent capacity (297 mAh g −1 anode ), high output voltage of 1.3 V, and extended cycle life (≈16000 cycles). Notably, they also operate efficiently at extremely low temperatures down to −85 °C with an 8 M KOH electrolyte. We further explore the feasibility for all-organic alkaline batteries by paring BCCs with the dihydro form of 4,4’-azopyridine, utilizing azo compounds for both anode and cathodes. This chemistry harnesses the unique properties of small organic molecules to enable all-organic batteries with high capacity of 236 mAh g –1 , fast charging at 1200 C, and easy recyclability.}, archive = {J_ANGEW}, author = {Jiapeng Zhao and Wenjin Zhang and Dawei Du and Zhihao Liu and Weixiao Ji and He Huang and Siping Pang}, doi = {10.1002/anie.202419887}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419887}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Skeletal rearrangement of azo compounds enables low-potential, high-capacity organic anodes for rechargeable alkaline batteries}, volume = {64}, year = {2025}, }
• (2025). Reversible and ultrasensitive detection of nitric oxide using a conductive two-dimensional Metal–Organic framework. ANGEW, 64(7), e202419869. (www)

  @article{ , abstract = {This paper describes the use of a highly crystalline conductive 2D copper 3 (hexaiminobenzene) 2 (Cu 3 (HIB) 2 ) as an ultrasensitive (limit of detection of 1.8 part-per-billion), highly selective, reversible, and low power chemiresistive sensor for nitric oxide (NO) at room temperature. The Cu 3 (HIB) 2 -based sensors retain their sensing performance in the presence of humidity, and exhibit strong signal enhancement towards NO over other highly toxic reactive gases, such as NO 2 , H 2 S, SO 2 , NH 3 , CO, as well as CO 2 . Mechanistic investigations of the Cu 3 (HIB) 2 -NO interaction through spectroscopic analyses and density functional theory revealed that the Cu-bis(iminobenzosemiquinoid) moieties serve as the binding sites for NO sensing, while the Ni-bis(iminobenzosemiquinoid) MOF analog shows no noticeable response to NO. Overall, these findings provide a significant advance in the development of crystalline metal-bis(iminobenzosemiquinoid)-based conductive 2D MOFs as highly sensitive, selective, and reversible sensing materials for the low-power detection of toxic gases.}, archive = {J_ANGEW}, author = {Hyuk-Jun Noh and Doran L. Pennington and Jeong-Min Seo and Evan Cline and Georganna Benedetto and Jong-Beom Baek and Christopher H. Hendon and Katherine A. Mirica}, doi = {10.1002/anie.202419869}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419869}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversible and ultrasensitive detection of nitric oxide using a conductive two-dimensional Metal–Organic framework}, volume = {64}, year = {2025}, }
• (2025). Bottom-up synthesis of piezoelectric covalent triazine-based nanotube for hydrogen peroxide production from water and air. ANGEW, 64(7), e202419867. (www)

  @article{ , abstract = {Carbon nanotubes (CNTs) are nanoscale tubular materials with superior mechanical strength and electronic properties. However, the conventional CNTs are inherently non-piezoelectric, mainly due to the lack of polar structures with pure carbon elements. The direct synthesis of fully conjugated and polarized organic nanotubes with desired piezoelectric properties remains a challenge. Herein, we report the bottom-up synthesis of a new type of covalent triazine-based nanotube (CTN-1) as a novel piezoelectric material. The CTN-1 comprises of high surface area, nitrogen-rich and fully conjugated structure, which provides a series of merits for piezoelectric catalytic processes. These structural features combined with one-dimensional tubular morphology endow CTN-1 with excellent mechanical stimuli response and thus displaying prominent piezoelectric properties via pronounced nanocurvature effect. We further show that the CTN-1 enables the efficient synthesis of H 2 O 2 from water in the air via mechanical energy conversion, with an excellent piezocatalytic H 2 O 2 evolution rate of 4115 μmol g −1 h −1 , which exceeds other reported piezoelectric materials. The piezocatalysis by the CTN-1 can be practically integrated into a self-Fenton system, which exhibits excellent pollutant degradation capability. This work demonstrates the enormous potential of a new type of piezoelectric synthetic nanotube from organic frameworks for the in situ synthesis valuable chemicals.}, archive = {J_ANGEW}, author = {Lijiang Guan and Zhi Li and Kai Wang and Li Gong and Yuanyuan Fang and Guipeng Yu and Mingshan Zhu and Shangbin Jin}, doi = {10.1002/anie.202419867}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419867}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bottom-up synthesis of piezoelectric covalent triazine-based nanotube for hydrogen peroxide production from water and air}, volume = {64}, year = {2025}, }
• (2025). Promoting photocatalytic hydrogen evolution by stabilization of excited triplet states and enhancement of internal electric field at Dye/PCN interface. ANGEW, 64(7), e202419850. (www)

  @article{ , abstract = {The heterojunction photocatalysts composed of organic dyes and polymeric carbon nitride (PCN) have great potential for photocatalytic hydrogen evolution (PHE). However, serious charge recombination exists at the dye/PCN interface for the large gaps in time scales and the poor driving force of charge transfer process. Herein, both the excited triplet states of organic dyes with long lifetimes and strong internal electric fields (IEF) as charge transfer driving forces are achieved by the construction of high dipole moments with aromatic-core engineering, and modulation of dye aggregates by alkyl modification. Accordingly, PHE efficiency can achieve up to 833.49 μmol/h, over 36-fold that of PCN/Pt (23.34 μmol/h) under the same conditions. The relationship between molecular structures and PHE performance has been systematically investigated by the photophysical properties of organic dyes and the strength of IEF at dye/PCN interface. It afforded an efficient strategy to balance the charge transfer process in PHE systems, which can guide the molecular design of organic dyes with optimized aggregated behaviors and stable excited triplet states.}, archive = {J_ANGEW}, author = {Yanting Chen and Changzun Jiang and Siwei Liu and Wentao Yuan and Qianqian Li and Zhen Li}, doi = {10.1002/anie.202419850}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419850}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting photocatalytic hydrogen evolution by stabilization of excited triplet states and enhancement of internal electric field at Dye/PCN interface}, volume = {64}, year = {2025}, }
• (2025). Enhancing the cumulene character of one-dimensional acetylene-based systems by stimuli-induced planarization of their two pro-diradicaloid cyclopenta[h,i]aceanthrylene units. ANGEW, 64(7), e202419832. (www)

  @article{ , abstract = {Acetylene/polyynes −(C≡C−) n and cumulenes =(C=) n are connectors widely used for the realization of one-dimensional (1D) π-conjugates. Although both π-moieties are constituted by sp carbon atoms, their different bond connectivity confers distinct physicochemical properties to the resulting systems. In this context, while many acetylene/polyyne- and cumulene-based derivatives have been prepared and studied, no reports have tackled the possibility to reversibly alter the acetylene/polyyne-cumulene electronic character of these derivatives using mild conditions. Herein, we present a novel approach to enhance the cumulene character of 1D acetylene-based conjugates consisting in the preparation of derivatives featuring an acetylene moiety connecting two pro-diradicaloid species, namely cyclopenta[ h,i ]aceanthrylene (CPA), at their pro-radical positions. A thoughtful spectroscopic study of the prepared dimers, complemented by theoretical calculations, suggest a high π-electronic delocalization of the pro-diradicaloid CPAs through the central acetylene spacer upon the dimers’ planarization which, in turn, increases the cumulenic character of the acetylenic π-bridge, a feature enhanced for one of the two dimers at low temperature and in methylcyclohexane due to an aggregation-induced planarization process. We reckon that the proposed approach offers an interesting avenue towards the realization of 1D systems which cumulenic character of the acetylenic π-connector could be altered in response to external stimuli.}, archive = {J_ANGEW}, author = {Álvaro Corrochano Fernández and Samara Medina Rivero and Sumit Chaurasia and Tomás Torres and Juan Casado and Giovanni Bottari}, doi = {10.1002/anie.202419832}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419832}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing the cumulene character of one-dimensional acetylene-based systems by stimuli-induced planarization of their two pro-diradicaloid cyclopenta[h,i]aceanthrylene units}, volume = {64}, year = {2025}, }
• (2025). Nano-springe enriched hierarchical porous MOP/COF hybrid aerogel: Efficient recovery of gold from electronic waste. ANGEW, 64(7), e202419830. (www)

  @article{ , abstract = {Extraction of gold from secondary resources such as electronic waste (e-waste) has become crucial in recent times to compensate for the gradual scarcity of the noble metal in natural mines. However, designing and synthesizing a suitable material for highly efficient gold recovery is still a great challenge. Herein, we have strategically designed rapid fabrication of an ionic crystalline hybrid aerogel by covalent threading of an amino-functionalized metal-organic polyhedra with an imine-linked chemically stable covalent organic framework at ambient condition. The hierarchically porous ultra-light aerogel featuring imine-rich backbone, high surface area, and cationic sites have shown fast removal, high uptake capacity (2349 mg/g), and excellent selectivity towards gold sequestration. Besides, the aerogel can extract ultra-trace gold-ions from different terrestrial water bodies, aiming towards safe drinking water. This study demonstrates the great potential of the composite materials based on a novel approach to designing a hybrid porous material for efficient gold recovery from complex water matrices.}, archive = {J_ANGEW}, author = {Dipanjan Majumder and Sahel Fajal and Mandar M. Shirolkar and Arun Torris and Yashasvi Banyla and Kishalay Biswas and Sagarmani Rasaily and Sujit K. Ghosh}, doi = {10.1002/anie.202419830}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nano-springe enriched hierarchical porous MOP/COF hybrid aerogel: Efficient recovery of gold from electronic waste}, volume = {64}, year = {2025}, }
• (2025). Boosting propane dehydrogenation to propylene via electron hole-hydrogen coupling on cobalt metal surface. ANGEW, 64(7), e202419816. (www)

  @article{ , abstract = {Nonoxidative dehydrogenation of propane is useful for the high selectivity to propylene but is suffering from the heavy coke deposition on the catalyst surface. Herein, we present a proof-of-concept application of a hole-hydrogen (H) couple on a metallic cobalt surface to decrease the deactivation rate. The coupled H atoms on the Cobalt (Co) surface, partially resulting from propane dehydrogenation, enabled the desorption of propylene to avoid deep hydrogenolysis and coke deposition and realize selective and durable propylene production, while conventional Co metal-based catalysts do not generate propylene. The optimized hole-H coupled Co catalyst provided a low deactivation rate (0.0036 h −1 ) and a high turnover frequency (55.6 h −1 ) for propylene production with a high propane flux (48 vol.% C 3 H 8 in gas feeds) at 550 °C.}, archive = {J_ANGEW}, author = {Dong Xu and Qi-Yuan Li and Qing-Xu Su and Si-Yuan Xia and Yu-Shuai Xu and Bing-Liang Leng and Xiu Lin and Liu-Yin Fan and Jie-Sheng Chen and Xin-Hao Li}, doi = {10.1002/anie.202419816}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419816}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting propane dehydrogenation to propylene via electron hole-hydrogen coupling on cobalt metal surface}, volume = {64}, year = {2025}, }
• (2025). Engineered reactive oxygen species (ROS)-responsive artificial H+/Cl− ion channels for targeted cancer treatment. ANGEW, 64(7), e202419800. (www)

  @article{ , abstract = {Reactive oxygen species (ROS)-responsive ion channels regulate the ion flow across the membranes in response to alterations in the cellular redox state, playing a crucial role in cellular adaptation to oxidative stress. Despite their significance, replicating ROS-responsive functionality in artificial ion channels remains elusive. In this study, we introduce a novel class of artificial H + /Cl − ion channels activatable by elevated ROS levels in cancer cells. ROS-induced decaging of the phenylboronate group triggers the rapid release of the channel-forming units, leading to self-assembly of the H-bonded cascades facilitating the synergistic transport of H + and Cl − ions, with H + /Cl − ion transport selectivity of 7.7. Upon activation, ROS-C-Cl exhibits significant apoptotic activity against human breast cancer cells, achieving an IC 50 of 2.8 μM, comparable to that of paclitaxel. Exploiting the intrinsic oxidative microenvironment of cancer cells, along with the enhanced oxidative stress arising from H + /Cl − co-transport, ROS-C-Cl demonstrates exceptional selectivity in targeting cancer cells with a selectivity index of 10.2 over normal breast cells, outperforming that of paclitaxel by 19.4 folds.}, archive = {J_ANGEW}, author = {Chunyan Jia and Daoxin Luo and Jin Zhou and Xiaopan Xie and Hilbert Yuen In Lam and Pengzhe Li and Yuguang Mu and Zhiping Zeng and Changliang Ren}, doi = {10.1002/anie.202419800}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419800}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered reactive oxygen species (ROS)-responsive artificial H+/Cl− ion channels for targeted cancer treatment}, volume = {64}, year = {2025}, }
• (2025). Ce3+/Ce4+ ion redox shuttle stabilized cuδ+ for efficient CO2 electroreduction to C2H4. ANGEW, 64(7), e202419796. (www)

  @article{ , abstract = {The CO 2 electroreduction reaction has advantages in clean and pollution-free carbon conversion, but it still faces challenges in carbon utilization efficiency and improving the selectivity of C 2 products. Although the dynamic Cu δ+ state is known to favor the C−C coupling process, the suitable Cu δ+ species for electrocatalytic reduction of CO 2 are difficult to maintain under the conditions of strong reduction and large current. Herein, we propose a Ce doping strategy to stabilize the Cu δ+ state (Ce/CuO x ) during the CO 2 RR process, which enables a high Faradaic efficiency of 60 % for multi-carbon products (40 % for C 2 H 4 , 14 % for CH 3 CH 2 OH, and 6 % for CH 3 COOH), and 25 h stability at −1.2 V versus the reversible hydrogen electrode. In situ infrared spectroscopy, in situ X-ray photoelectron spectroscopy combined with density functional theory calculations reveal that the Cu δ+ is stabilized by the redox ion pairs of Ce, which reduces the energy barrier of *CO coupling, and improves the Faraday efficiency of electrocatalytic CO 2 reduction of C 2 H 4 . This work provides a new idea to make full use of lanthanide variable value metals for advanced catalysis and clean energy conversion.}, archive = {J_ANGEW}, author = {Xiang Liu and Ting Liu and Ting Ouyang and Jiguang Deng and Zhao-Qing Liu}, doi = {10.1002/anie.202419796}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419796}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ce3+/Ce4+ ion redox shuttle stabilized cuδ+ for efficient CO2 electroreduction to C2H4}, volume = {64}, year = {2025}, }
• (2025). Toward rhenium-based circularly polarized OLEDs using tailored chiral Re(CO)3 emitters. ANGEW, 64(7), e202419788. (www)

  @article{ , abstract = {Chiral rhenium(I) emitters exhibiting circularly polarized phosphorescence (CPP) are an attractive mainstay for CP organic light-emitting diodes (CP-OLEDs). However, the efficiency of such emitters is not ideal, and they have never been explored for circularly polarized electroluminescence (CPEL) applications. Here, we have tailored robust chiral Re(I) complexes with improved CPP properties, and demonstrated CPEL from rhenium emitters for the first time. Two pairs of enantiomeric Re(I) complexes have been synthesized by introducing of one or two chiral menthol groups into 1,10-phenanthroline unit (phen) of archetypical emitters [ReBr(CO) 3 (phen)]. The designed complexes exhibit a yellow CPP with enhanced | g lum | factors (up to 2.5×10 −2 ) and a good quantum efficiency. The pioneering Re(I)-based CP-OLEDs (based on the obtained emitters) exhibit yellow CPEL with | g EL | factors of up to 6.2×10 −3 and a maximal external quantum efficiency of 13.2 %. This work highlights the good potential of chiral Re(I) emitters for CPEL applications, and opens up a new shortcut to CPP-active Re(I) complexes.}, archive = {J_ANGEW}, author = {Maria P. Davydova and Ting Xu and Alexander M. Agafontsev and Lingqiang Meng and Mariusz Wolff and Maxim Yu. Petyuk and Irina Yu. Bagryanskaya and Alexey S. Berezin and Alexey V. Tkachev and Hong Meng and Alexander V. Artem'ev}, doi = {10.1002/anie.202419788}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419788}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Toward rhenium-based circularly polarized OLEDs using tailored chiral Re(CO)3 emitters}, volume = {64}, year = {2025}, }
• (2025). Carbon-centered reactivity in carbodiphosphorane-based ligands allowing for redox-non-innocent Ligand/Ligand dual bond-activation. ANGEW, 64(7), e202419786. (www)

  @article{ , abstract = {A pronounced nucleophilicity in combination with a distinct redox non-innocence is a unique feature of a coordinated ligand, which in the current case, leads to unprecedented carbon-centered reactivity patterns: A carbodiphosphorane-based (CDP) pincer-type rhodium complex allows to cleave two C–Cl-bonds of geminal dichlorides via two consecutive S N 2-type oxidative additions resulting in the formation of a stabilized carbene fragment. In the presence of a suitable reductant the carbene fragment can even be converted into olefines or hydrodehalogenation products in a catalytic reaction. The developed method can also be used to convert chlorofluorocarbons (CFCs) such as CH 2 ClF to fluoromethane and methane. The strong nucleophilic character of coordinated CDPs is also reflected in the low potential for oxidation, which favors radical reactivity and gives rise to an unique cationic C-centered radical CDP ligand, which is capable of a carbon-centered dihydrogen activation, following an unprecedented radical mechanism involving ligand/ligand-cooperativity (LLC).}, archive = {J_ANGEW}, author = {Philipp Schatz and Weiqin Xu and Sebastian Rynek and Leon Maser and Niels Heise and Olaf Fuhr and Dieter Fenske and Haleh Hashemi Haeri and Dariush Hinderberger and Matthias Vogt and Robert Langer}, doi = {10.1002/anie.202419786}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon-centered reactivity in carbodiphosphorane-based ligands allowing for redox-non-innocent Ligand/Ligand dual bond-activation}, volume = {64}, year = {2025}, }
• (2025). Side chain phenyl isomerization-induced spatial conjugation for achieving efficient near-infrared II phototheranostic agents. ANGEW, 64(7), e202419785. (www)

  @article{ , abstract = {The contradiction of near-infrared II (NIR-II) emission and photothermal effects limits the development of phototheranostic agents (PTAs) in many emerging cutting-edge applications. Organic aggregates present a promising opportunity for the balance of competitive relaxation processes through the manipulation of molecular structure and packing. Herein, side chain phenyl isomerization-induced spatial conjugation was proposed for constructing A-D-A type NIR-II PTAs with simultaneous enhancement of fluorescence brightness and photothermal properties. Three pairs of mutually isomeric fluorophores, whose phenyls respectively located at the outside ( o -series) and inside ( i -series) of the side chain, were designed and synthesized. The positional isomerization of the phenyl endows the o -series crystals with strong spatial conjugation between the phenyl group on the side chain and the backbone, as well as interlocked planar network, which is different to that observed in the i -series. Thus, all o -series nanoparticles (NPs) exhibit red-shifted absorption, enhanced NIR-II emission, and superior photothermal properties than their i -series counterparts. A prominent member of the o -series, o -ITNP NPs, demonstrated efficacy in facilitating NIR-II angiography, tumor localization, and NIR-II imaging-guided tumor photothermal therapy. The success of this side chain phenyl isomerization strategy paves the way for precise control of the aggregation behavior and for further development of efficient NIR-II PTAs.}, archive = {J_ANGEW}, author = {Chunbin Li and Mengfan Yao and Guoyu Jiang and Lina Feng and Yifan Wu and Renmanduhu Sha and Yonghai Li and Ben Zhong Tang and Jianguo Wang}, doi = {10.1002/anie.202419785}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419785}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Side chain phenyl isomerization-induced spatial conjugation for achieving efficient near-infrared II phototheranostic agents}, volume = {64}, year = {2025}, }
• (2025). Supramolecular assembly enhanced linear and nonlinear chiroptical properties of chiral manganese halides. ANGEW, 64(7), e202419776. (www)

  @article{ , abstract = {Chiral hybrid organic–inorganic metal halides (HOMHs) hold great promise in broad applications ranging from ferroelectrics, spintronics to nonlinear optics, owing to their broken inversion symmetry and tunable chiroptoelectronic properties. Typically, chiral HOMHs are constructed by chiral organic cations and metal anion polyhedra, with the latter regarded as optoelectronic active units. However, the primary design approaches are largely constrained to regulation of general components within structural formula. Herein, supramolecular approaches have been taken for the functionalization of chiral enantiomers by anchoring chiral cations with crown ether hosting molecules. Chiral HOMHs of R -/ S -(18-crown-6@ClMBA) 2 MnBr 4 have been thus obtained with boosted linear and nonlinear chiroptical properties. The self-assembled cations lead to enhanced structural rigidity, which promote near-unity green light emission and strong circularly polarized luminescence with a high asymmetry factor, along with high efficiency second-order nonlinear optical responses. In particular, these chiral HOMH single crystals demonstrate a sensitive discrimination for circularly polarized laser in the near-infrared region with the nonlinear optical asymmetry factor ( g SHG-CD ) as high as 1.8. This work highlights the contribution of supramolecular assembly in improving chiroptical performances, offering valuable insights for the design of new chiral HOMH materials with promising application potentials as linear and nonlinear CPL emitters and detectors.}, archive = {J_ANGEW}, author = {Xiao Han and Puxin Cheng and Huanxin Yang and Junjie Guan and Mingyang Xin and Geng Li and Xiyan Li and Yongshen Zheng and Jialiang Xu and Xian-He Bu}, doi = {10.1002/anie.202419776}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419776}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular assembly enhanced linear and nonlinear chiroptical properties of chiral manganese halides}, volume = {64}, year = {2025}, }
• (2025). Towards the use of low-concentration CO2 sources by direct selective electrocatalytic reduction. ANGEW, 64(7), e202419775. (www)

  @article{ , abstract = {The direct CO 2 reduction reaction (CO 2 RR) from simulated flue gas of various CO 2 concentrations could minimize extra energy for pre-concentration processes to highly concentrated CO 2 as a feedstock. We investigate the challenges for CO 2 RR caused by low CO 2 concentrations and provide strategies concerning the impact of the chosen electrocatalyst material and the selection of the electrolyte to attain high CO selectivity. We continuously feed CO 2 mixed with N 2 (the typical dilutant in flue gas) in various ratios to gas diffusion electrodes in a model flow-through electrolyzer. Operating the CO 2 RR at lower CO 2 concentrations results in an overpotential shift to more cathodic values. We show that higher active catalysts can maintain high CO selectivity down to 5 % CO 2 by using NiCu-based catalysts. NiCu reached its limit when the CO 2 concentration was lowered to 2 %, due to low CO 2 availability and competition of carbonate formation. Employing near-neutral electrolytes with buffering capacity, we maintained high Faradaic efficiency at low overpotentials and higher CO 2 utilization at low CO 2 concentration.}, archive = {J_ANGEW}, author = {Muhammad Adib Abdillah Mahbub and Debanjan Das and Xin Wang and Guilong Lu and Martin Muhler and Wolfgang Schuhmann}, doi = {10.1002/anie.202419775}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419775}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards the use of low-concentration CO2 sources by direct selective electrocatalytic reduction}, volume = {64}, year = {2025}, }
• (2025). Sb-to-P metathesis: A direct route to structurally constrained, cationic PIII compound. ANGEW, 64(7), e202419772. (www)

  @article{ , abstract = {Structurally constrained, cationic P III compound [ LP ][ SbCl 4 ] with an OCO pincer-type ligand ( L ) having a central carbene donor was directly synthesized via an Sb-to-P metathesis reaction between PCl 3 and LSb-Cl . [ LP ][ SbCl 4 ] was isolated and its reactivity with small molecules (ROH and RNH 2 ) was studied, showing that [ SbCl 4 ] − is not an innocent counter anion, but an active participant in these reactions. When the [ SbCl 4 ] − was replaced with the [ CB 11 H 12 ] − ([ Cb ] − ) anion, the reactions were redirected to [ LP ] + cation only. The reactions with alcohols and amines led to the equilibrium between the products of the formal E−H (E=O, N) bond oxidative addition to the P-center and products of the P-center/ligand-assisted bond activation. Remarkably, [ LP ] + activated the PhO−H and PhN(H)−H bonds in a reversible, thermoneutral fashion.}, archive = {J_ANGEW}, author = {Deependra Bawari and Irina Malahov and Roman Dobrovetsky}, doi = {10.1002/anie.202419772}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sb-to-P metathesis: A direct route to structurally constrained, cationic PIII compound}, volume = {64}, year = {2025}, }
• (2025). High configuration entropy promises electrochemical stability of chloride electrolytes for high-energy, long-life all-solid-state batteries. ANGEW, 64(7), e202419735. (www)

  @article{ , abstract = {Solid-state electrolytes (SSEs) with high ionic conductivity, stability, and interface compatibility are indispensable for high-energy-density and long-life all-solid-state batteries (ASSBs), yet there are scarce SSEs with sufficient ionic conductivity and electrochemical stability. In this study, with a high-entropy SSE (HE-SSE, Li 2.9 In 0.75 Zr 0.1 Sc 0.05 Er 0.05 Y 0.05 Cl 6 ), we show the high configuration entropy has a thermodynamically positive relationship with the high-voltage stability. As a result, the ASSBs with HE-SSE and high-voltage cathode materials exhibit superior high-voltage and long-cycle stability, achieving 250 cycles with 81.4 % capacity retention when charged to 4.8 V (vs. Li + /Li), and even 5000 cycles if charged to 4.6 V (vs. Li + /Li). Experimental characterizations and density functional theory calculations confirm that the HE-SSE greatly suppresses the high-voltage degradation of SSE at the interface, promoting the high-voltage stability coordinately through high entropy and interface stability. The high entropy design offers a general strategy to simultaneously improve the high-voltage stability and ionic conductivity of SSEs, creating an avenue to building high-energy and long-life ASSBs.}, archive = {J_ANGEW}, author = {Deyuan Li and Dongfang Yu and Guangwen Zhang and Ao Du and Zilin Ye and Yiran Jia and Weiqi Hou and Tianze Xu and Fangbing Li and Sijia Chi and Yizhou Zhu and Chunpeng Yang}, doi = {10.1002/anie.202419735}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419735}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High configuration entropy promises electrochemical stability of chloride electrolytes for high-energy, long-life all-solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). Hydrogen/Electron amphiphilic bi-functional water molecular inactivator-assisted interface stabilization in highly reversible zn metal batteries. ANGEW, 64(7), e202419732. (www)

  @article{ , abstract = {Continuous hydrogen-bond-network in aqueous electrolytes can lead to uncontrollable hydrogen transfer, and combining the interfacial parasitic electron consumption cause the side reaction in aqueous zinc metal batteries (AZMBs). Herein, hydrogen/electron amphiphilic bi-functional 1,5-Pentanediol (PD) molecule was introduced to stabilize the electrode/electrolyte interface. Stronger proton affinity of -OH in PD can break bulk-H 2 O hydrogen-bond-network to inhibit the activity of water, and electron affinity can enhance electron acceptation capability, which ensures that PD is preferentially bound to electrode material over H 2 O. Besides, the participation of PD in the Zn 2+ solvation structure reduces water content at the solid–liquid interface and promotes uniform deposition process by optimizing Zn 2+ de-solvation energy. Accordingly, dense and vertical zinc texture based on intrinsic steric hindrance effect of PD and formed SEI protective layer to induce stable Zinc anode-electrolyte interface. Moreover, an organic–inorganic shielding water layer was formed at the cathode side to suppress vanadium dissolution in vanadium Oxide. Consequently, Zn//Zn symmetric cell could cycle for more than 5600 hours at 1 mAh cm −2 @1 mA cm −2 (more than 250 hours at 50 °C). Besides, the VO 2 and I 2 cathode all achieved stable cycling performance and former pouch cell could reach average capacity of 0.13 Ah.}, archive = {J_ANGEW}, author = {Wenwei Zhang and Shaohua Zhu and Tong Yang and Lu Wu and Jinghao Li and Jiang Liang and Yu Liu and Lianmeng Cui and Chen Tang and Xinran Chen and Huiqing Zhou and Fan Qiao and Min Zhou and Ping Luo and Fengtong Chi and Xiaobin Liao and Lei Zhang and Qinyou An}, doi = {10.1002/anie.202419732}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419732}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen/Electron amphiphilic bi-functional water molecular inactivator-assisted interface stabilization in highly reversible zn metal batteries}, volume = {64}, year = {2025}, }
• (2025). Program-modulated kinetics of perovskite-film growth by molecular “Thruster” for high-efficiency and stable perovskite solar cells. ANGEW, 64(7), e202419726. (www)

  @article{ , abstract = {The rapid reaction between lead iodide (PbI 2 ) and formamidinium iodide (FAI) complicates the fabrication of high-quality formamidinium lead iodide (FAPbI 3 ) films. Conventional methods, such as using nonvolatile small molecular additives to slow the reaction, often result in buried interfacial voids and molecule diffusion, compromising the devices’ operational stability. In this study, we introduced a molecular “thruster”—a hypervalent iodine (III) compound with three carbonyl groups and a C − −I + bond—that possesses coordination and dissociation abilities, enabling programed modulation of perovskite-film growth kinetics. Initially, the three carbonyl groups coordinate with PbI 2 to slow the reaction between FAI and PbI 2 , preventing δ-phase formation. As temperature rises, the C − −I + bond dissociates, promoting perovskite growth and the dissociated product iodobenzene will promote solvent volatilization, thus avoiding buried interfacial voids. Another product, a carbene compound with eight lone pair electrons sufficiently passivate the undercoordinated Pb 2+ defects and anchors at grain boundaries without diffusion. Consequently, the resultant FAPbI 3 film displays high-quality with enhanced phase purity, compact morphology, and reduced defects. Evidently, 0.062- and 1.004-cm 2 pero-SCs achieve power conversion efficiencies (PCEs) of up to 26.06 % (25.79 % certified) and 24.65 %, respectively. This approach also controls perovskite-film growth on plastic substrates, resulting in flexible pero-SCs with an impressive PCE of 25.12 %.}, archive = {J_ANGEW}, author = {Chuanshuai Han and Yeyong Wu and Guiying Xu and Xiaoxiao Wu and Jiacheng Xu and Tingting Xu and Shihao Huang and Yunxiu Shen and Zhiyun Cao and Weijie Chen and Xiaoping Xu and Yaowen Li}, doi = {10.1002/anie.202419726}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419726}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Program-modulated kinetics of perovskite-film growth by molecular “Thruster” for high-efficiency and stable perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Photoregulated supramolecular polymerization through halogen bonding. ANGEW, 64(7), e202419720. (www)

  @article{ , abstract = {Supramolecular polymers are able to change their structure, morphology and function in response to external stimuli. However, controlling the independence of stimuli-responses in these systems is challenging. Herein, we exploit halogen bonding (XB) as a reversible network element to regulate the photoresponsive and adaptive behavior of supramolecular polymers. To this end, we have designed a two-component system comprising an amphiphilic XB acceptor with the ability to self-assemble in aqueous media ( OPE-Py ) and a molecule with a dual photoresponsive and XB donor function [ ( E )-Azo-I ]. OPE-Py self-assembles in aqueous media into supramolecular polymers, which transform into nanoparticle assemblies upon co-assembly with ( E )-Azo-I . Interestingly, a third type of assembly (2D sheets) is obtained if OPE-Py is treated with ( E )-Azo-I and exposed to photoirradiation. At ambient conditions, both nanoparticles and 2D sheets remain invariant over time. However, heating dissociates the XB interactions present in both assemblies, resulting in their transformation to the original fiber-like morphology of OPE-Py . Thus, breaking the communication between self-assembly and the stimuli-responses upon heating restores the original state of the system, drawing parallels to feedback loops in programming language. This work broadens the still limited scope of XB in solution assemblies and paves the way for multifunctional adaptive supramolecular systems.}, archive = {J_ANGEW}, author = {Alejandro Martínez Manjarres and Antonia Albers and Gustavo Fernández}, doi = {10.1002/anie.202419720}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419720}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoregulated supramolecular polymerization through halogen bonding}, volume = {64}, year = {2025}, }
• (2025). High-efficiency trifluoromethyl-methionine incorporation into cyclophilin a by cell-free synthesis for 19F NMR studies. ANGEW, 64(7), e202419709. (www)

  @article{ , abstract = {Fluorine-19 NMR spectroscopy has emerged as a powerful tool for studying protein structure, dynamics, and interactions. Of particular interest is the exploitation of trifluoromethyl (tfm) groups, given their high sensitivity and superior transverse relaxation properties, compared to single fluorine atoms. However, biosynthetic incorporation of tfm-bearing amino acids remains challenging due to cytotoxicity and incompatibility with natural tRNA synthetases. Here, we report on overcoming this challenge using cell-free synthesis, incorporating trifluoromethyl-methionine (tfmM) into the protein Cyclophilin A (CypA) with remarkably high efficiency, impossible via biosynthetic means. Importantly, we demonstrate that tfmM CypA binds a native substrate, the N-terminal domain of HIV-1 capsid protein (HIV-1 CA-NTD), and retains peptidyl prolyl cis / trans isomerase activity. It also binds the peptide inhibitor Cyclosporine A (CsA) with the same affinity as non-labeled, wild-type CypA. Furthermore, we show that 19 F isotope shifts and 19 F solvent paramagnetic relaxation enhancements (PREs) provide valuable structural information on surface exposure. Taken together, our study illustrates that tfmM can be readily incorporated into proteins at very high levels by cell-free synthesis without disturbing protein structure and function, significantly expanding the scope of 19 F NMR spectroscopy for studying protein structure and dynamics.}, archive = {J_ANGEW}, author = {Wenkai Zhu and Christina M. Monnie and Kristīne Kitoka and Angela M. Gronenborn}, doi = {10.1002/anie.202419709}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419709}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-efficiency trifluoromethyl-methionine incorporation into cyclophilin a by cell-free synthesis for 19F NMR studies}, volume = {64}, year = {2025}, }
• (2025). Aeration-free photo-fenton-like reaction mediated by heterojunction photocatalyst toward efficient degradation of organic pollutants. ANGEW, 64(7), e202419680. (www)

  @article{ , abstract = {The regulation of peroxymonosulfate (PMS) activation by photo-assisted heterogeneous catalysis is under in-depth investigation with potential as a replaceable advanced oxidation process in water purification, yet it remains a significant challenge. Herein, we demonstrate a strategy to construct polyethylene glycol (PEG) well-coupled dual-defect V O −M–Co 3 O 4 @CN x S-scheme heterojunction to degrade organic pollutants without aeration, which dramatically provides abundant active sites, excellent photo-thermal property, and distinct charge transport pathway for PMS activation. The degradation rate of V O −M−Co 3 O 4 @CN x in anaerobic conditions shows a higher efficient rate (4.58 min −1 g −2 ) than in aerobic conditions (1.67 min −1 g −2 ). Experimental evidence reveals that V O −M−Co 3 O 4 @CN x promotes more rapid redox conversion of photoexcited electrons induced by defects with PMS under anaerobic conditions compared to aerobic conditions. Additionally, in situ experiments and DFT provide mechanistic insights into the regulation pathway of PMS activation via synergistic defect-induced electron, revealing the competitive effect between O 2 and PMS over V O −M−Co 3 O 4 @CN x during the reaction process. The continuous flow reactor and flow cytometry results demonstrated that the V O −M−Co 3 O 4 @CN x /PMS/Vis system has remarkably enhanced stability and purification capability for removing organic pollutants. This work provides valuable insights into regulating the heterologous catalysis oxidation process without aeration through the photoexcitation synergistic PMS activation.}, archive = {J_ANGEW}, author = {Yan Wang and Lianxin Li and Puyang Zhou and Yu Gan and Weipeng Liu and Yiwen Wang and Yilin Deng and Hongping Li and Meng Xie and Yuanguo Xu}, doi = {10.1002/anie.202419680}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aeration-free photo-fenton-like reaction mediated by heterojunction photocatalyst toward efficient degradation of organic pollutants}, volume = {64}, year = {2025}, }
• (2025). Rechargeable lithium-hydrogen gas batteries. ANGEW, 64(7), e202419663. (www)

  @article{ , abstract = {The global clean energy transition and carbon neutrality call for developing high-performance batteries. Here we report a rechargeable lithium metal - catalytic hydrogen gas (Li−H) battery utilizing two of the lightest elements, Li and H. The Li−H battery operates through redox of H 2 /H + on the cathode and Li/Li + on the anode. The universal properties of the H 2 cathode enable the battery to demonstrate attractive electrochemical performance, including high theoretical specific energy up to 2825 Wh kg −1 , discharge voltage of 3 V, round-trip efficiency of 99.7 %, reversible areal capacity of 5–20 mAh cm −2 , all-climate characteristics with a wide operational temperature range of −20–80 °C, and high utilization of active materials. A rechargeable anode-free Li−H battery is further constructed by plating Li metal from cost-effective lithium salts under a low catalyst loading of <0.1 mg cm −2 . This work presents a route to design batteries based on catalytic hydrogen gas cathode for high-performance energy storage applications.}, archive = {J_ANGEW}, author = {Zaichun Liu and Yirui Ma and Nawab Ali Khan and Taoli Jiang and Zhengxin Zhu and Ke Li and Kai Zhang and Shuang Liu and Zehui Xie and Yuan Yuan and Mingming Wang and Xinhua Zheng and Jifei Sun and Weiping Wang and Yahan Meng and Yan Xu and Mingyan Chuai and Jinlong Yang and Wei Chen}, doi = {10.1002/anie.202419663}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419663}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rechargeable lithium-hydrogen gas batteries}, volume = {64}, year = {2025}, }
• (2025). Weakly solvating cyclic ether-based deep eutectic electrolytes for stable high-temperature lithium metal batteries. ANGEW, 64(7), e202419653. (www)

  @article{ , abstract = {Deep eutectic electrolytes (DEE) have emerged as an innovative approach to address the instability and safety issues of lithium metal batteries at elevated temperatures. However, in practice, there is often an undesirable incompatibility between the eutectic mixture and electrodes, and also an insufficient reduction stability of DEE due to the increased Li + concentration. Herein, we designed a new DEE by utilizing weakly solvating tetrahydropyran (THP) solvent. Due to the high reduction resistance of THP and concentrated lithium bis(trifluoromethanesulfonyl)imide (LiTFSI), this DEE demonstrates enhanced compatibility with Li metal anode and high temperature tolerance with LiMn 2 O 4 cathode. The Li||LiMn 2 O 4 cell (1.6 mAh cm −2 ) shows a high capacity retention of 96.02 % after 600 cycles at room temperature. More importantly, this Li||LiMn 2 O 4 cell achieves a remarkable high-temperature performance with a high capacity retention of 91.72 % after 120 cycles and low self-discharge after storage for 240 hours at a high temperature of 55 °C, which is critical for LiMn 2 O 4 cathode. Overall, this electrolyte design provides an alternative pathway for the development of DEEs for high-temperature and high-voltage lithium metal batteries, which can also be expanded to other batteries.}, archive = {J_ANGEW}, author = {Yanru Yang and Qin Li and Huan Li and Jiafeng Ruan and Fengmei Wang and Ziyue Li and Jinyu Yang and Jiayun Zhang and Uğur Çağlayan and Dalin Sun and Fang Fang and Muharrem Kunduraci and Fei Wang}, doi = {10.1002/anie.202419653}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419653}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Weakly solvating cyclic ether-based deep eutectic electrolytes for stable high-temperature lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Sabatier optimal of mn-n4 single atom catalysts for selective oxidative desulfurization. ANGEW, 64(7), e202419630. (www)

  @article{ , abstract = {Understanding the relationship of competitive adsorption between reactants is the prerequisite for high activity and selectivity in heterogeneous catalysis, especially the difference between the adsorption energies ( E ads ) of two reactive intermediates in Langmuir–Hinshelwood (L−H) models. Using oxidative dehydrogenation of hydrogen sulfide (H 2 S-ODH) as a probe, we develop various metal single atoms on nitrogen-doped carbon (M-NDC) catalysts for controlling E ads -H 2 S, E ads -O 2 and investigating the difference in activity and selectivity. Combining theoretical and experimental results, a Sabatier relationship between the catalytic performance and E ads -O 2 / E ads -H 2 S emerges. Mn-NDC as the optimal catalyst shows excellent H 2 S conversion (>90 %) and sulfur selectivity (>90 %) in a wide range of O 2 concentrations over 100 h. Such a high-efficiency performance is attributed to appropriate E ads -H 2 S and E ads -O 2 on Mn-N 4 sites, boosting redox cycle between Mn 2+ and Mn 3+ , as well as preferential formation of sulfur. This work provides a fundamental guidance for designing Sabatier optimal catalysts in L−H models.}, archive = {J_ANGEW}, author = {Hanfeng Ye and Wandong Xing and Fei Zhao and Jiali Wang and Can Yang and Yidong Hou and Jinshui Zhang and Jimmy C. Yu and Xinchen Wang}, doi = {10.1002/anie.202419630}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419630}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sabatier optimal of mn-n4 single atom catalysts for selective oxidative desulfurization}, volume = {64}, year = {2025}, }
• (2025). Enhanced photocatalytic synthesis of urea from co-reduction of n2 and CO2 on Z-schematic SrTiO3-FeS-CoWO4 heterostructure. ANGEW, 64(7), e202419628. (www)

  @article{ , abstract = {The photocatalytic co-reduction of CO 2 and N 2 is a sustainable method for urea synthesis under mild conditions. However, high-yield synthesis of urea is a challenge due to the sluggish kinetics of the C−N coupling reaction. Herein, we have successfully engineered a Z-scheme photocatalyst, SrTiO 3 -FeS-CoWO 4 , for boosting photocatalytic urea synthesis via enhancing the initial CO 2 and N 2 adsorption step and reducing the energy barrier for the C−N coupling reaction. A high urea yield of 8054.2 μg ⋅ g cat −1 ⋅ h −1 was achieved on SrTiO 3 -FeS-CoWO 4 , which was significantly higher than the state-of-the-art. The SrTiO 3 -FeS-CoWO 4 Z-scheme photocatalyst, with accelerated charge transfer by FeS, not only had dual active sites for the chemical adsorption and activation of CO 2 and N 2 , but also retained the high conduction band (−1.50 eV) and accelerated supply of electrons and protons, which are responsible for its good photoreduction activity and significantly reduced energy barrier for the rate-determining step of C−N coupling reaction.}, archive = {J_ANGEW}, author = {Muhammad Irfan Ahmad and Yanming Liu and Yaqi Wang and Peike Cao and Hongtao Yu and Houfen Li and Shuo Chen and Xie Quan}, doi = {10.1002/anie.202419628}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419628}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced photocatalytic synthesis of urea from co-reduction of n2 and CO2 on Z-schematic SrTiO3-FeS-CoWO4 heterostructure}, volume = {64}, year = {2025}, }
• (2025). Dynamic phosphorescence behavior of carbene-metal-amide complexes from the perspective of excited state modulation. ANGEW, 64(7), e202419614. (www)

  @article{ , abstract = {Carbene-metal-amide (CMA) complexes have diverse applications in luminescence, imaging and sensing. In this study, we designed and synthesized a series of CMA complexes, which were subsequently doped into a PMMA host. These materials demonstrate light-induced dynamic phosphorescence, attributed to their long intrinsic triplet state lifetime ( τ P ,int , in the μs-ms scale), high intersystem crossing (ISC) rate constant ( k ISC , up to 10 7 s −1 ), and bright phosphorescence. The extended τ P ,int , and elevated k ISC facilitate efficient sensitization of singlet oxygen ( 1 O 2 ) under light irradiation, which is rapidly consumed by the host material, creating a localized anaerobic environment conducive to bright phosphorescence emission. The S n -T 1 process exhibits a large spin-orbital coupling matrix element (SOCME) value, while the SOCME value between T 1 and S 0 is comparatively smaller, resulting in a large k ISC and long τ P ,int , Computational results indicate that the hole-electron configuration in the lowest triplet state exhibits low contributions from gold. Based on the dynamic phosphorescence properties, an encryption material capable of achieving a “burn after reading” effect was developed. This work illustrates that those phosphorescent emitters with minimal heavy atom contribution can produce dynamic phosphorescent phenomena, providing a novel strategy for designing stimuli-responsive phosphorescent materials.}, archive = {J_ANGEW}, author = {Xiang-Ming Zeng and Minjian Wu and Liao-Yuan Yao and Guo-Yu Yang}, doi = {10.1002/anie.202419614}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419614}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic phosphorescence behavior of carbene-metal-amide complexes from the perspective of excited state modulation}, volume = {64}, year = {2025}, }
• (2025). Boosting the performance of iridium single atom catalyst in a porous organic polymer for glycerol conversion to lactic acid. ANGEW, 64(7), e202419607. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) inherit the merit of both homogeneous and heterogeneous systems with atomically dispersed mononuclear metal centers on the solid supports. Herein, we developed an Ir-SAC catalyst via the polymerization of an active homogeneous 2-picolinylhydrazone ligand-based iridium (Ir) metal complex. Such catalysts provide great stabilization against migration and agglomeration due to the strong covalent C−C bond linkage of active complexes and the polymer matrix. This Ir-SAC catalyst shows excellent selectivity towards glycerol to lactic acid conversion with a remarkable recyclability to offer an unprecedentedly high TON of over 104 million under optimized conditions.}, archive = {J_ANGEW}, author = {Yadagiri Rachuri and Sandeep Suryabhan Gholap and Amol M. Hengne and Mohammad Misbahur Rahman and Indranil Dutta and Mohamed Ben Hassine and Shibo Xi and Kuo-Wei Huang}, doi = {10.1002/anie.202419607}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419607}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting the performance of iridium single atom catalyst in a porous organic polymer for glycerol conversion to lactic acid}, volume = {64}, year = {2025}, }
• (2025). Improving the cellular internalization of Zr(IV) nanocages by tuning hydrophilicity and lipophilicity. ANGEW, 64(7), e202419602. (www)

  @article{ , abstract = {Nanoscale molecular materials have emerged as a new class of compounds at the nanometer scale with well-defined chemical structures, remarkable uniformity and high reproducibility. Among these materials, zirconium-based metal-organic cages (MOCs) have attracted significant attention due to their exceptional stability and applications in catalysis, recognition and separation and so on. However, their poor water solubility impedes their biomedical applications. In this study, decorating the ligand with Ru(II) complexes can not only improve the water solubility but also endow bright red fluorescence with large Stokes shift (180 nm). Notably, butyl-modification of the cyclopentadiene rings can significantly enhance the cell uptake (100 folds) of nanocages via actin- and dynamin-mediated endocytosis. The unique advantages and easy modifiability of these nanocages make them highly promising candidates for diverse biological applications.}, archive = {J_ANGEW}, author = {Shunfu Du and Jinxiao Lyu and Zhenfeng Yu and Kongzhao Su and Wenjing Wang and Xuanjun Zhang and Daqiang Yuan}, doi = {10.1002/anie.202419602}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving the cellular internalization of Zr(IV) nanocages by tuning hydrophilicity and lipophilicity}, volume = {64}, year = {2025}, }
• (2025). Asymmetric S-arylation of sulfenamides to access axially chiral sulfilimines enabled by anionic stereogenic-at-Cobalt(III) complexes. ANGEW, 64(7), e202419596. (www)

  @article{ , abstract = {An efficient enantioselective coupling reaction between sulfenamides and cyclic diaryliodonium salts is established via adaptive Cu/anionic stereogenic-at-Co(III) complex combined catalysis, precisely synthesizing a broad range of axially chiral sulfilimines with excellent enantioselectivities, diastereoselectivities, regioselectivities, and chemoselectivities (67 examples under same conditions, up to 98 % ee). The following thermodynamically controlled pyramidal inversion enables efficient stereodivegent synthesis of all four stereoisomers. Mechanistic studies suggest that anionic stereogenic-at-cobalt(III) complexes serve as counteranions of diaryliodonium and anionic ligand of Cu(I) catalyst simultaneously, which could be regarded as an explanation for outstanding selectivities.}, archive = {J_ANGEW}, author = {Wei Fang and Yan-Dong Meng and Shu-Ying Ding and Ju-Yan Wang and Zheng-Hao Pei and Meng-Lan Shen and Chuan-Zhi Yao and Qiankun Li and Zhenhua Gu and Jie Yu and Hua-Jie Jiang}, doi = {10.1002/anie.202419596}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419596}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric S-arylation of sulfenamides to access axially chiral sulfilimines enabled by anionic stereogenic-at-Cobalt(III) complexes}, volume = {64}, year = {2025}, }
• (2025). Reconstructing the coordination environment of Fe/Co dual-atom sites towards efficient oxygen electrocatalysis for Zn–Air batteries. ANGEW, 64(7), e202419595. (www)

  @article{ , abstract = {Dual-atom catalysts with nitrogen-coordinated metal sites embedded in carbon can drive the oxygen reduction and evolution reactions (ORR/OER) in rechargeable zinc–air batteries (ZABs), and the further improvement is limited by the linear scaling relationship of intermediate binding energies in the absorbate evolution mechanism (AEM). Triggering the lattice oxygen mechanism (LOM) is promising to overcome this challenge, but has yet been verified since the lacking of bridge oxygen (O) in the rigid coordination environment of the metal centers. Here, we demonstrate that suitably tailored dual-atom catalysts of FeCo−N−C can undergo out-plane and in-plane reconstruction to form the both axial O and bridge O at the metal centers, and thus activate the LOM pathway. The tailored FeCo−N−C with shortened Fe−N bonds also favors the ORR process, therefore is a promising dual-atom oxygen catalyst. The assembled rechargeable ZABs demonstrate a peak power density of 332 mW cm −2 , and exhibit no notable decline after ~720 h of continuous cycling.}, archive = {J_ANGEW}, author = {Hengqi Liu and Jinzhen Huang and Kun Feng and Rui Xiong and Shengyu Ma and Ran Wang and Qiang Fu and Moniba Rafique and Zhiguo Liu and Jiecai Han and Daxing Hua and Jiajie Li and Jun Zhong and Xianjie Wang and Zhonglong Zhao and Tai Yao and Sida Jiang and Ping Xu and Zhihua Zhang and Bo Song}, doi = {10.1002/anie.202419595}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419595}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reconstructing the coordination environment of Fe/Co dual-atom sites towards efficient oxygen electrocatalysis for Zn–Air batteries}, volume = {64}, year = {2025}, }
• (2025). Screened d-p orbital hybridization in turing structure of confined nickel for sulfion oxidation accelerated hydrogen production. ANGEW, 64(7), e202419572. (www)

  @article{ , abstract = {The sulfion oxidation reaction (SOR) could offer an energy-efficient and tech-economically favorable alternative to the oxygen evolution reaction (OER) for H 2 production. Transition metal (TM) based catalysts have been considered promising candidates for SOR but suffer from limited activity due to the excessive bond strength from TM-S 2− d-p orbit coupling. Herein, we propose a feasible strategy of screening direct d-p orbit hybridization between TM and S 2− by constructing the Turing structure composed of lamellar stacking carbon-confined nickel nanosheets. The optimized p-p orbit coupling between electron-injected carbon and S 2− enables exceptional catalytic activity and stability for sulfion degradation and energy-efficient yet value-added H 2 production. Specifically, it achieves a current density of 500 mA cm −2 at an ultralow potential of 0.67 V vs. RHE for alkaline SOR. Theoretical calculations indicate that the electron transfer from Ni imparts metallicity and a higher p-band center to carbon shells, thereby contributing to optimized p-p orbit hybridization and a thermodynamically favorable stepwise sulfion degradation. Practically, a two-electrode flow cell achieves an industrial current density of 1 A cm −2 at an unprecedented low voltage of 0.91 V while maintaining stability for over 300 hours, and exhibits high productivities of 3.83 and 0.32 kg h −1 m −2 for sulfur and H 2 , respectively.}, archive = {J_ANGEW}, author = {Yin Zhu and Shao Wang and Yanxu Chen and Yangyang Zhang and Yafei Feng and Genqiang Zhang}, doi = {10.1002/anie.202419572}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Screened d-p orbital hybridization in turing structure of confined nickel for sulfion oxidation accelerated hydrogen production}, volume = {64}, year = {2025}, }
• (2025). Organic cathode electrolyte interphase achieving 4.8 v LiCoO2. ANGEW, 64(7), e202419539. (www)

  @article{ , abstract = {Developing high-voltage electrolytes to stabilize LiCoO 2 (LCO) cycling remains a challenge in lithium-ion batteries. Constructing a high-quality cathode electrolyte interphase (CEI) is essential to mitigate adverse reactions at high voltages. However, conventional inorganic CEIs dominated by LiF have shown limited performance for high-voltage LCO. Here, we propose an ionic liquid electrolyte (ILE) with a high donor number additive, enabling Li//LCO cells to achieve a high cut-off voltage of 4.7 V/4.8 V and a high-capacity retention of 86.9 %/74.2 % after 100 cycles at 0.5 C. During this process, a groundbreaking phenomenon was discovered: the construction of a stable organic CEI rich in C−F bonds by the high donor number additive under high voltage. These strong polar C−F bonds exhibit excellent electrochemical inertness and film-forming properties, resulting in optimal passivation of the cathode. This organic C−F bond-dominated CEI significantly suppresses phase transitions, cobalt dissolution, and gas evolution in LCO at high voltage. Additionally, the 4.8 V-class Li//LiNi 0.6 Co 0.2 Mn 0.2 O 2 and 4.95 V-class Li//LiNi 0.5 Mn 1.5 O 4 cells also demonstrate outstanding cycling stability. Even at 60 °C, the ILE-constructed organic CEI maintains superior performance. Our findings highlight the potential of organic CEI to enhance high-voltage cathode stability, paving the way for more efficient lithium-ion batteries.}, archive = {J_ANGEW}, author = {Chaocang Weng and Meijia Qiu and Bingfang Wang and Jiaqi Yang and Wenjie Mai and Likun Pan and Sumei Huang and Jinliang Li}, doi = {10.1002/anie.202419539}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419539}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic cathode electrolyte interphase achieving 4.8 v LiCoO2}, volume = {64}, year = {2025}, }
• (2025). Structural and functional characterization of an amidase targeting a polyurethane for sustainable recycling. ANGEW, 64(7), e202419535. (www)

  @article{ , abstract = {Global plastic production exceeded 400 million tons in 2022, urgently demanding improved waste management and recycling strategies for a circular plastic economy. While the enzymatic hydrolysis of polyethylene terephthalate (PET) has become feasible on industrial scales, efficient enzymes targeting other hydrolyzable plastic types, such as polyurethanes (PURs), are lacking. Recently, enzymes of the amidase signature (AS) family, capable of cleaving urethane bonds in a polyether-PUR analog and a linear polyester-PUR, have been identified. Herein, we present high-resolution crystal structures of the AS enzyme UMG-SP3 in three states: ligand-free, bound with a suicidal inhibitor mimicking the transition state, and bound with a monomeric PUR degradation product. Besides revealing the conserved core and catalytic triad akin to other AS family members, the UMG-SP3 structures show remarkable flexibility of loop regions. Particularly, Arg209 in loop 3 adopts two induced-fit conformations upon ligand binding. Through structure-guided kinetic studies and enzyme engineering, we mapped structural key elements that determine the enhanced hydrolysis of urethane and amide bonds in various small molecules, including a linear PUR fragment analog. Our findings contribute critical insights into urethanase activity, aiding PUR degradation campaigns and sustainable plastic recycling efforts in the future.}, archive = {J_ANGEW}, author = {Laura Rotilio and Thomas Bayer and Hannes Meinert and Luis M. C. Teixeira and Martin B. Johansen and Andreas Sommerfeldt and Allan R. Petersen and Alexander Sandahl and Malene B. Keller and Jesper Holck and Pedro Paiva and Daniel E. Otzen and Uwe T. Bornscheuer and Ren Wei and Pedro A. Fernandes and Maria J. Ramos and Peter Westh and J. Preben Morth}, doi = {10.1002/anie.202419535}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419535}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural and functional characterization of an amidase targeting a polyurethane for sustainable recycling}, volume = {64}, year = {2025}, }
• (2025). Dynamic covalent spiropyran exchange for rapid structural diversification. ANGEW, 64(7), e202419531. (www)

  @article{ , abstract = {Here we disclose that spiropyrans are able to undergo dynamic covalent exchange via their corresponding merocyanine isomers. In the latter, the indolinium moieties can be exchanged by a Michael-type addition-elimination sequence, in which a methylene indoline attacks a merocyanine and subsequently the initial indoline fragment is cleaved. The rate and position of the exchange equilibrium strongly depend on the reaction conditions as well as the substitution pattern on the methylene indoline fragments. Importantly, spiropyran cross exchange is catalyzed by indolinium salts and provides the opportunity for rapid in situ structural diversification of spiropyrans. This was used as synthetic tool to access various, hitherto inaccessible spiropyrans as potential dual-color photoinitiators for xolography. Moreover, we foresee application to screen dynamic covalent libraries of spiropyrans for photochromic properties and to exploit their light-sensitivity to bias the thermal equilibrium.}, archive = {J_ANGEW}, author = {Alwin Drichel and Yves Garmshausen and Stefan Hecht}, doi = {10.1002/anie.202419531}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419531}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic covalent spiropyran exchange for rapid structural diversification}, volume = {64}, year = {2025}, }
• (2025). Controlled lipid domain positioning and polarization in confined minimal cell models. ANGEW, 64(7), e202419529. (www)

  @article{ , abstract = {Giant unilamellar vesicles (GUVs) are widely used minimal cell models where essential biological features can be reproduced, isolated and studied. Although precise spatio-temporal distribution of membrane domains is a process of crucial importance in living cells, it is still highly challenging to generate anisotropic GUVs with domains at user-defined positions. Here we describe a novel and robust method to control the spatial position of lipid domains of liquid-ordered (Lo)/liquid-disordered (Ld) phase in giant unilamellar vesicles. Our strategy consists in confining Lo/Ld phase-separating GUVs in microfluidic channels to define free curved regions where the minority-phase domains localize and coalesce by decreasing the line energy through domain fusion. We show that this process is governed by the respective fraction of the two phases, and not by the chemical nature of the lipids involved. The spatial position and number of domains are controlled by the design of the confining microchannel and could result in polarized GUVs with a controllable number of poles. The developed method is versatile and user-friendly, while allowing multiple single-vesicle experiments in parallel.}, archive = {J_ANGEW}, author = {Koyomi Nakazawa and Antoine Lévrier and Sergii Rudiuk and Ayako Yamada and Mathieu Morel and Damien Baigl}, doi = {10.1002/anie.202419529}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419529}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled lipid domain positioning and polarization in confined minimal cell models}, volume = {64}, year = {2025}, }
• (2025). One-pot cobalt- or copper-catalyzed asymmetric ring-opening Hydrosilylation/Hydroboration of arylidenecyclopropanes. ANGEW, 64(7), e202419522. (www)

  @article{ , abstract = {An operationally convenient cobalt-catalyzed one-pot one-step hydrosilylation/hydroboration reaction of arylidenecyclopropanes is developed to access racemic 1,4-borylsilylalkanes. In addition, the corresponding asymmetric reaction is developed with a chiral copper catalyst to prepare 1,4-borylsilylalkanes with high enantioselectivity by a one-pot two-step procedure. Mechanistic studies reveal that this difunctionalization process begins with metal-hydride-catalyzed ring-opening hydrosilylation of arylidenecyclopropanes to generate homoallylsilane intermediates, followed by regio- or enantioselective metal-hydride-catalyzed hydroboration of homoallylsilanes to produce skipped borylsilylalkanes. Selective transformations of C−B and Si−H bonds in skipped borylsilylalkane products are also demonstrated.}, archive = {J_ANGEW}, author = {Boon Beng Tan and Shaozhong Ge}, doi = {10.1002/anie.202419522}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419522}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-pot cobalt- or copper-catalyzed asymmetric ring-opening Hydrosilylation/Hydroboration of arylidenecyclopropanes}, volume = {64}, year = {2025}, }
• (2025). Klebsiella pneumoniae glycoconjugate vaccine leads based on semi-synthetic o1 and o2ac antigens. ANGEW, 64(7), e202419516. (www)

  @article{ , abstract = {Klebsiella pneumoniae (KP) is a common opportunistic pathogen that emerged as a new critical threat to human health, due to its hypervirulence and widespread resistance against many antibiotics, including carbapenems. Alternative intervention strategies such as vaccines are not available. Cell-surface lipopolysaccharides (LPS) and capsular polysaccharides (CPS) are attractive targets for vaccine development. We present a method to synthesize LPS substructures, covering over 70 % of virulent KP strains that were used to characterize the antibody repertoire of infected patients. Thereby, glycoconjugate vaccine leads against the Klebsiella pneumoniae serotypes O1, O2a, O2afg and O2ac have been identified.}, archive = {J_ANGEW}, author = {Julinton Sianturi and Fabienne Weber and Rajat Kumar Singh and Tilman Lingscheid and Pinkus Tober-Lau and Florian Kurth and Bettina C. Fries and Peter H. Seeberger}, doi = {10.1002/anie.202419516}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Klebsiella pneumoniae glycoconjugate vaccine leads based on semi-synthetic o1 and o2ac antigens}, volume = {64}, year = {2025}, }
• (2025). Zwitterionic 2-phosphaethene-thiolates [(LC)P=CS(LC/P)]+ as PCS building blocks (LC=NHC, LP=PR3). ANGEW, 64(7), e202419502. (www)

  @article{ , abstract = {The zwitterionic compounds [(L C )P=CS(L C/P )] + ( 3 + , L C =NHC, L P =PR 3 ), featuring cationic substituents at the phosphorus and carbon atoms, are synthesized as their triflate salts at a multi-gram scale from the reaction of Lewis base adducts of CS 2 , namely L C/P −CS 2 ( 4 ), with a combination of [(L C P) 4 ][OTf] 4 ( 1 [OTf] 4 ) and Ph 3 P. The feasibility of using 3 + as PCS building blocks is showcased in their reactions with representative electrophiles (MeOTf) and nucleophiles (MesMgBr, Ph 3 PCH 2 ), leading to selective functionalization of the PCS core at the S - and P -terminus, respectively. Additionally, it is reported that 3 + can function as ambident nucleophiles with AgOTf (2 equivalents), affording unprecedented linear coordination polymer [Ag 2 (OTf) 3 -μ 2 :κ P ,κ S −((L C )P=CS(PCy 3 ))] + ( 6 b ), where the PCS moiety acts as a bridging ligand in transition metal complexes for the first time. Reduction of 3 + facilitates the cleavage of the P - and C -bound substituents leading to the formation of the [PCS] − anion. Moreover, cycloaddition reactions of 3 + with 1 [OTf] 4 are shown to selectively yield five- and eight-membered polyphosphorus heterocycles. Preliminary results suggest the possibility of activating the C−S bond in [(L C )P=CS(L C )] + , resulting in the formation of [(L C )P=C(L C )−P(L C )][OTf] 2 , 12 [OTf] 2 , which may serve as a synthon for the PCP unit in future studies.}, archive = {J_ANGEW}, author = {Philipp Royla and Kai Schwedtmann and Rosa M. Gomila and Antonio Frontera and Jan J. Weigand}, doi = {10.1002/anie.202419502}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zwitterionic 2-phosphaethene-thiolates [(LC)P=CS(LC/P)]+ as PCS building blocks (LC=NHC, LP=PR3)}, volume = {64}, year = {2025}, }
• (2025). Reductive C(sp2)−Si cross-couplings by catalytic sodium-bromine exchange. ANGEW, 64(7), e202419496. (www)

  @article{ , abstract = {The metal-halogen exchange reaction constitutes one of the most important preparative routes towards polar organometallic reagents such as aryllithium or Grignard reagents. However, despite extensive developments over the past eight decades, this fundamental organometallic elementary step has only been exploited stoichiometrically. Against this background, we demonstrate that the sodium-bromine exchange reaction can be implemented in a catalytic setting as a mean to activate C(sp 2 )−Br bonds in a transition metal-free manner en route to the regioselective and general preparation of (hetero)aryl silanes. Simply treating structurally diverse (hetero)aryl bromides with N - tert -butyl- N’ -silyldiazenes ( t Bu−N=N− Si ) as silylating reagents and inexpensive sodium alkoxides as catalytic promoters yields a range of aromatic organosilicon compounds under ambient conditions. Mechanistic studies provide solid evidence for the involvement of tert -butyl sodium as the C(sp 2 )−Br metalating agent.}, archive = {J_ANGEW}, author = {Baptiste Neil and Thomas Deis and Louis Fensterbank and Clément Chauvier}, doi = {10.1002/anie.202419496}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reductive C(sp2)−Si cross-couplings by catalytic sodium-bromine exchange}, volume = {64}, year = {2025}, }
• (2025). Sulfurized composite interphase enables a highly reversible zn anode. ANGEW, 64(7), e202419495. (www)

  @article{ , abstract = {The stability and reversibility of Zn anode can be greatly improved by in situ construction of solid electrolyte interphase (SEI) on Zn surface via a low-cost design strategy of ZnSO 4 electrolyte. However, the role of hydrogen bond acceptor -SO 3 accompanying ZnS formation during SEI reconstruction is overlooked. In this work, we have explored and revealed the new role of -SO 3 and ZnS in the in situ formed sulfide composite SEI (SCSEI) on Zn anode electrochemistry in ZnSO 4 aqueous electrolytes. Structure characterization and DFT demonstrate that the introduction of -SO 3 can not only reduce the dehydration energy of [Zn(H 2 O) 6 ] 2+ , but also enhance the stability of the ZnS/Zn interface and homogenize the ZnS/Zn interface electric field, thereby significantly improving the dynamic kinetics and uniform deposition of Zn 2+ . Owing to the synergistic effect of ZnS and -SO 3 , a high cycling stability of 1500 h with a cumulative-plated capacity of 7.5 Ah cm −2 at 10 mA cm −2 has been achieved within the symmetrical cell. Furthermore, the full cell with NH 4 V 4 O 10 cathode exhibits outstanding cyclic stability, exceeding 2000 cycles at 5 A g −1 and maintaining a Coulombic efficiency of 100 %. These new insights into anionic synergistic strategy could significantly enhance the practical application of zinc-ion batteries.}, archive = {J_ANGEW}, author = {Lu Wu and Hao Yuan and Yongkang An and Jianguo Sun and Yu Liu and Han Tang and Wei Yang and Lianmeng Cui and Jinghao Li and Qinyou An and Yong-Wei Zhang and Lin Xu and Liqiang Mai}, doi = {10.1002/anie.202419495}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419495}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sulfurized composite interphase enables a highly reversible zn anode}, volume = {64}, year = {2025}, }
• (2025). Access to polyhydroxyalkanoates with diverse syndiotacticity via polymerization by spiro-salen complexes and insights into the stereocontrol mechanism. ANGEW, 64(7), e202419494. (www)

  @article{ , abstract = {Polyhydroxyalkanoates (PHAs) have attracted broad interest as promising sustainable materials to address plastic pollution and resource scarcity. However, the chemical synthesis of stereoregular PHAs via ring-opening polymerization (ROP) has long been an elusive endeavor. In this contribution, we exploited a robust spiro-salen yttrium complex ( Y3 ) as the catalyst to successfully prepare syndiotactic PHAs with diverse pendent groups. Simply altering the ratio of enantiomeric catalysts allowed to access of PHAs with diverse syndiotacticity ( P r =0.5–0.99, from sticky oil to tough materials), delivering tunable thermal properties (glass transition temperature, T g from −52 to 70 °C and melting transition temperature, T m from 38 to 223 °C). A combined experimental and computational study suggested a polymeric exchange mechanism could boost the polymerization activity and control the syndioselectivity.}, archive = {J_ANGEW}, author = {Hao-Yi Huang and Bai-Hao Ren and Min Xie and Yu-Ting Huang and Kun Li and Zhongzheng Cai and Xiao-Bing Lu and Jian-Bo Zhu}, doi = {10.1002/anie.202419494}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419494}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Access to polyhydroxyalkanoates with diverse syndiotacticity via polymerization by spiro-salen complexes and insights into the stereocontrol mechanism}, volume = {64}, year = {2025}, }
• (2025). Anion-tailored EDL induced triple-layer SEI on high-capacity anodes enabling fast-charging and durable sodium-storage. ANGEW, 64(7), e202419490. (www)

  @article{ , abstract = {High-capacity electrodes face a great challenge of cycling stability due to particle fragmentation induced conductive network failure and accompanied by sustained electrolyte decomposition for repeatedly build solid electrolyte interphase (SEI). Herein, Se-solubility induced Se x 2− as self-adjustment electrolyte additive to regulate electric double layer (EDL) for constructing novel triple-layer SEI (inner layer: Se; mediate layer: inorganic; outer layer: organic) on high-capacity FeS 2 anode as an example for achieving stable and fast sodium storage. In detail, Se x 2− in situ generated at 1.30 V (vs. Na + /Na) and was preferentially adsorbed onto EDL of anode, then converted to Se 0 as inner layer of SEI. In addition, the Se x 2− causes anion-enhanced Na + solvation structure could produce more inorganic (Se 0 , NaF) and less organic SEI components. The unique triple-layer SEI with layer-by-layer dense structure alleviate the excessive electrolyte consumption with less gas evolution. As a result, the anode delivered long-lifespan at 10 A g −1 (383.7 mAh g −1 , 6000 cycles, 93.1 %, 5 min/cycle). The Se-induced triple-layer SEI could be also be formed on high-capacity SnS 2 anode. This work provides a novel SEI model by anion-tailored EDL towards stable sodium-storage of high-capacity anode for fast-charging.}, archive = {J_ANGEW}, author = {Jun Luo and Kaiwei Yang and Jingjing Gai and Xixue Zhang and Chengbin Peng and Changdong Qin and Yang Ding and Yifei Yuan and Zhengkun Xie and Pengfei Yan and Yuliang Cao and Jun Lu and Weihua Chen}, doi = {10.1002/anie.202419490}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419490}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion-tailored EDL induced triple-layer SEI on high-capacity anodes enabling fast-charging and durable sodium-storage}, volume = {64}, year = {2025}, }
• (2025). Physical isolation of single protein molecules within well-defined coordination cages to enhance their stability. ANGEW, 64(7), e202419476. (www)

  @article{ , abstract = {Encapsulation of a single protein within a confined space can lead to distinct properties compared to bulk solutions, but controlling the number of encapsulated proteins and their environment remains challenging. This study demonstrates the encapsulation of single proteins within well-defined, tunable cavities of self-assembled coordination cages, thereby enhancing protein stability. Within uniform cavities of size-tunable coordination cages, 15 different proteins of varying sizes (3–6 nm in diameter) and properties (e.g., isoelectric points and hydrophobicity) were successfully confined. Various analytical techniques confirmed that the proteins maintained their secondary structures and enzymatic activities under denaturing conditions such as exposure to organic solvents, heat, and buffers. These findings suggest that such coordination cages have the potential to serve as synthetic hosts for precisely controlling protein functions within their customizable cavities.}, archive = {J_ANGEW}, author = {Risa Ebihara and Takahiro Nakama and Ken Morishima and Maho Yagi-Utsumi and Masaaki Sugiyama and Daishi Fujita and Sota Sato and Makoto Fujita}, doi = {10.1002/anie.202419476}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419476}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Physical isolation of single protein molecules within well-defined coordination cages to enhance their stability}, volume = {64}, year = {2025}, }
• (2025). Microbe engineering to provide drimane-type building blocks for chiral pool synthesis of meroterpenoids. ANGEW, 64(7), e202419463. (www)

  @article{ , abstract = {Drimane-type merosesquiterpenoids (DMT) are a class of natural products with diverse structures and broad biological activity. Classical DMT synthesis relies on atom-inefficient plant-derived chiral pool building blocks, while alternative drimane-type building blocks such as drimenol and albicanol offer more direct routes but face production challenges. In this study, we engineered a microbial platform for efficient production of these building blocks. By optimizing the PhoN-IPK system through rational engineering and incorporating a Nudix hydrolase, we achieved a drimenol production of 398 mg/L and high albicanol titers of 1805 mg/L in shake flasks and 3.5 g/L in a bioreactor. Structural analysis and molecular dynamics simulations of the engineered PhoN provided insights into its improved catalytic efficiency. We demonstrated the utility of this platform by synthesizing several DMT using albicanol as the starting material, reducing the number of synthetic steps and improving overall efficiency as compared to classical approaches.}, archive = {J_ANGEW}, author = {Wenyu Du and Zhongyu Cheng and Xingming Pan and Chenhao Liu and Mingyu Yue and Tianhao Li and Zhixi Xiao and Lu-Lu Li and Xuelan Zeng and Xiaoxu Lin and Fuzhuo Li and Liao-Bin Dong}, doi = {10.1002/anie.202419463}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419463}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Microbe engineering to provide drimane-type building blocks for chiral pool synthesis of meroterpenoids}, volume = {64}, year = {2025}, }
• (2025). Reaction pathway regulation for gaseous and liquid products of electrocatalytic CO2 reduction under adsorbate interactions. ANGEW, 64(7), e202419456. (www)

  @article{ , abstract = {Halide anion adsorption on transition metals can improve the performance of electrochemical CO 2 reduction reaction (CO 2 RR), while the specific reaction mechanisms governing selective CO 2 RR pathways remain unclear. In this study, we reveal for the first time the distinct pathway switching between gaseous (CO) and liquid products (formate and ethanol) on the well-defined Ag−Cu nanostructures with controlled chlorination. We show that CO 2 conversion to CO on Ag/AgCl can be tuned by adjusting the thickness of AgCl layer, achieving a high selectivity over a broad potential range in a 0.5 M KHCO 3 using flow cell. In contrast, the optimized Cl−Ag/Cu system enables the conversion of CO 2 into liquid products including formate and ethanol with a total Faradaic efficiency (FE) nearing 100 %, delivering high current densities of 136.3 and 20.8 mA cm −2 at −1.3 V, respectively. In situ infrared experiments and theoretical calculations indicate that the lateral adsorbate of *OCHO intermediate facilitates the thermodynamics of both the CO pathway on Cl−Ag(111) and the formate pathway on Cl−Ag/Cu(111) by reducing Gibbs free energy barriers of each potential-limit step. This work uncovers the role of chlorination in the tuning of C-bound or O-bound intermediates during CO 2 RR on Ag−Cu catalysts, determining the reaction pathway under lateral adsorbate effects.}, archive = {J_ANGEW}, author = {Feng Hu and Xiaoqian Xu and Yajie Sun and Chuan Hu and Shuning Shen and Ying Wang and Lei Gong and Linlin Li and Shengjie Peng}, doi = {10.1002/anie.202419456}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reaction pathway regulation for gaseous and liquid products of electrocatalytic CO2 reduction under adsorbate interactions}, volume = {64}, year = {2025}, }
• (2025). Aliphatic amines unlocked for selective transformations through diazotization. ANGEW, 64(7), e202419450. (www)

  @article{ , abstract = {While aromatic diazonium salts are important reagents in organic synthesis, ‘Diazonium ions generated from ordinary aliphatic primary amines are usually useless for preparative purposes, since they lead to a mixture of products giving not only substitution by any nucleophile present, but also elimination and rearrangements if the substrate permits .’ 1 In this work, we report that this statement is no longer valid, and it is now possible to control diazotization of aliphatic amines by utilizing isopentyl nitrite in HFIP. This transformation enabled electrophilic aromatic substitution with these highly abundant and commercially available alkyl reagents, as well as transforming them into building blocks typically employed in organic synthesis. The methodology opens an avenue for reactions involving aliphatic amines, even such demanding substrates as amino acids, as a source of carbocations thus expanding the degree of chemical space.}, archive = {J_ANGEW}, author = {Jakub Durka and Barbara Zielińska and Dorota Gryko}, doi = {10.1002/anie.202419450}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419450}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aliphatic amines unlocked for selective transformations through diazotization}, volume = {64}, year = {2025}, }
• (2025). Sulfur-rich norbornadiene-derived infrared transparent polymers by inverse vulcanization. ANGEW, 64(7), e202419446. (www)

  @article{ , abstract = {Infrared (IR) transparent polymer materials prepared by inverse vulcanization, as a promising candidate to replace inorganic materials, are new materials for constructing key devices in IR optics. However, it is difficult to achieve a balance between infrared optical and thermal properties in polymers due to the intrinsic infrared absorption of organic materials. Herein, our strategy is to construct a high boiling point symmetrical molecular norbornadiene derivative cross-linking agent (DMMD) which can be inverse vulcanized with molten sulfur, and obtain Poly (S-r-DMMD) with different sulfur content by controlling the feed ratio of sulfur. With the rigid core and low IR activity in DMMD, the prepared polymers exhibit tunable thermal properties ( T g : 98.3–119.8 °C) and high IR transmittance (medium-wave infrared region (MWIR): 42.9–52.6 %; long-wave infrared region (LWIR): 1.5–5.29 %). In addition, Poly (S-r-DMMD) can be used to prepare large-size free-standing Fresnel lenses for IR imaging by simple hot-pressing, which provides flexibility in the design and production of IR fine lenses. This study provides a novel strategy for balancing the thermal and optical properties of IR transparent polymer materials, while providing relevant references for balancing the IR optical and thermal properties of polymer materials.}, archive = {J_ANGEW}, author = {Yishun Wuliu and Weiliang Dong and Guohua Huang and Hui Xie and Pingping Yao and Jiji Tan and Kexin Mu and Zhili Zhang and Yinan Chen and Mingliang Wang and Lei Tian and Caizhen Zhu and Jian Xu}, doi = {10.1002/anie.202419446}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419446}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sulfur-rich norbornadiene-derived infrared transparent polymers by inverse vulcanization}, volume = {64}, year = {2025}, }
• (2025). Molecular-level modulation of n, S-co-doped mesoporous carbon nanospheres for selective aqueous catalytic oxidation of ethylbenzene. ANGEW, 64(7), e202419438. (www)

  @article{ , abstract = {Selective oxidation of aromatic alkanes into high value-added products through benzylic C−H bond activation is one of the main reactions in chemical industry. On account of the constantly increasing demand for mass production, efficient, eco-friendly and sustainable catalysts are urgently needed. Herein, we describe a facile and versatile emulsion-assisted interface self-assembly strategy towards molecular-level fabrication of co-doped mesoporous carbon nanospheres with controllable active N and S species. The method enables a high degree of control over nanoparticle sizes, mesoporous nanostructures, contents of heteroatoms and the chemical composition. The optimized catalyst exhibits high catalytic performance of 97 % ethylbenzene conversion and 98 % selectivity to acetophenone. Density functional theory simulations reveal that N, S-co-doping leads to the redistribution of charge and spin densities, introducing more active carbon atoms and realizing aerobic oxidation of ethylbenzene efficiently. This work presents a general strategy for molecular-level design of carbon-based catalysts, and also provides new insight into the influence of heteroatom-doping on catalytic properties.}, archive = {J_ANGEW}, author = {Yumeng Liu and Liangliang Zhang and Zhengwen Tan and Wenyue Sun and Ling Zhang and Zhen-An Qiao}, doi = {10.1002/anie.202419438}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419438}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular-level modulation of n, S-co-doped mesoporous carbon nanospheres for selective aqueous catalytic oxidation of ethylbenzene}, volume = {64}, year = {2025}, }
• (2025). A helical tubular dyad of [9]Cycloparaphenylene: Synthesis, chiroptical properties and post-functionalization. ANGEW, 64(7), e202419435. (www)

  @article{ , abstract = {The bottom-up synthesis of discrete tubular molecules that mimic the structural features of carbon nanotubes has been a long-standing pursuit for synthetic chemists. As the shortest segments of armchair-type carbon nanotubes, cycloparaphenylenes are regarded as ideal macrocyclic building blocks for achieving this goal. Here we report the synthesis of a helical tubular molecule featuring three diyne linkers between two site-specifically functionalized [9]cycloparaphenylenes. Its C 3 -symmetrical, radially conjugated structure and solid-state packing have been elucidated by spectroscopic and crystallographic characterizations. Notably, the resolved enantiomers display a circularly polarized luminescence brightness value of 1.47×10 3 M −1 cm −1 , which is among the highest values for chiral organic molecules. Furthermore, the diyne-linked molecule could be directly converted into a thiophene-linked helical molecule, demonstrating the post-functionalization approach for the construction of chiral tubular molecules from cycloparaphenylenes.}, archive = {J_ANGEW}, author = {Gaolei Li and Liang-Liang Mao and Jia-Nan Gao and Xueliang Shi and Zi-Ye Huo and Jingxuan Yang and Wen Zhou and Hongwei Li and Hai-Bo Yang and Chen-Ho Tung and Li-Zhu Wu and Huan Cong}, doi = {10.1002/anie.202419435}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419435}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A helical tubular dyad of [9]Cycloparaphenylene: Synthesis, chiroptical properties and post-functionalization}, volume = {64}, year = {2025}, }
• (2025). Chiral rotaxane-branched dendrimers as relays in artificial light-harvesting systems with boosted circularly polarized luminescence. ANGEW, 64(7), e202419434. (www)

  @article{ , abstract = {Starting from AIEgen-functionalized chiral [2]rotaxane building block, we have successfully synthesized a new class of chiral rotaxane-branched dendrimers through controllable divergent strategy for the first time, based on which novel chiral artificial light-harvesting systems (LHSs) were successfully constructed in aqueous phase by sequentially introducing achiral donor and acceptor. More importantly, accompanied by the two-step Förster resonance energy transfer (FRET) process in the resultant artificial LHSs, the sequentially amplified circularly polarized luminescence (CPL) performances were achieved, highlighting that the chiral rotaxane-branched dendrimers could serve as excellent relay for both energy transfer and chirality transmission. Impressively, compared with the sole chiral rotaxane-branched dendrimers, the dissymmetry factors ( g lum ) values of the resultant artificial LHSs were amplified by one order of magnitude up to 0.038, enabling their further applications in information storage and encryption. The proof-of concept study provides not only a feasible approach for the efficient amplification of CPL performances but also a novel platform for the construction of novel chiral luminescent materials.}, archive = {J_ANGEW}, author = {Xiao-Qin Xu and Wei-Jian Li and Dan-Yang Zhang and Yu Zhu and Wei-Tao Xu and Yu Wang and Xu-Qing Wang and Wei Wang and Hai-Bo Yang}, doi = {10.1002/anie.202419434}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419434}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral rotaxane-branched dendrimers as relays in artificial light-harvesting systems with boosted circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Twisted-planar molecular engineering with sonication-induced J-aggregation to design near-infrared J-aggregates for enhanced phototherapy. ANGEW, 64(7), e202419428. (www)

  @article{ , abstract = {J-aggregates show great promise in phototherapy, but are limited to specific molecular skeletons and poor molecular self-assembly controllability. Herein, we report a twisted-planar molecular strategy with sonication-induced J-aggregation to develop donor–acceptor (D–A) type J-aggregates for phototherapy. With propeller aggregation-induced emission (AIE) moieties as the twisted subunits and thiophene as the planar π-bridge, the optimal twisted-planar π-interaction in MTSIC induces appropriate slip angle and J-aggregates formation, redshifting the absorption from 624 nm to 790 nm. In contrast, shorter π-planarity results in amorphous aggregates, and elongation promotes charge transfer (CT) coupled J-aggregates. Sonication was demonstrated to be effective in controlling self-assembly behaviors of MTSIC, which enables the transformation from amorphous aggregates to H-intermediates, and finally to stable J-aggregates. After encapsulation with lipid-PEG, the resultant J-dots show enhanced phototherapeutic effects over amorphous dots, including brightness, reactive oxygen species (ROS) generation, and photothermal conversion, delivering superior cancer phototherapy performance. This work not only advances D–A type J-aggregates design but also provides a promising strategy for supramolecular assembly development.}, archive = {J_ANGEW}, author = {Yubo Liu and Yuchen Song and Zhong-Hong Zhu and Chao Ji and Jianqing Li and Hanyu Jia and Yang Shi and Fang Hu and Zujin Zhao and Dan Ding and Ben Zhong Tang and Guangxue Feng}, doi = {10.1002/anie.202419428}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419428}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Twisted-planar molecular engineering with sonication-induced J-aggregation to design near-infrared J-aggregates for enhanced phototherapy}, volume = {64}, year = {2025}, }
• (2025). Photoredox activation of donor-acceptor cyclopropanes: Distonic radical cation reactivity in [3+2] cycloaddition reactions. ANGEW, 64(7), e202419426. (www)

  @article{ , abstract = {Altering the reactivity model of a molecule can potentially eliminate limitations existing in its current paradigm. When it comes to the activation of Donor-Acceptor Cyclopropanes (DACs), Lewis acids have been the state-of-the-art. Although a variety of polarized 2π components have been successfully coupled with DACs for [3+2] cycloaddition, unpolarized alkenes prove to be a roadblock due to an inherent polarity mismatch with the Lewis acid-mediated 1,3-zwitterionic intermediate. Hereby, harnessing the distonic radical cation mode of cleavage by photoredox catalysis overcomes this mismatched reactivity of the zwitterionic intermediate, providing a unique route to highly substituted cyclopentanes and cyclopentenes. Expansion of this strategy to bicyclo[1.1.0]butanes enables access to bicyclo[3.1.1]heptanes (BCHs) through a facile [3 σ +2 σ ] cycloaddition. Detailed mechanistic insights are also provided using dispersion-corrected density functional theory.}, archive = {J_ANGEW}, author = {Subhashis Mondal and Saradindu Debnath and Rabindranath Lo and Soumitra Maity}, doi = {10.1002/anie.202419426}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoredox activation of donor-acceptor cyclopropanes: Distonic radical cation reactivity in [3+2] cycloaddition reactions}, volume = {64}, year = {2025}, }
• (2025). Cationic metal-organic layer delivers siRNAs to overcome radioresistance and potentiate cancer radiotherapy. ANGEW, 64(7), e202419409. (www)

  @article{ , abstract = {Radiotherapy plays an important role in modern oncology, but its treatment efficacy is limited by the radioresistance of tumor cells. As a member of the inhibitor of apoptosis protein family, survivin plays a key role in developing radioresistance by mediating apoptosis evasion, promoting epithelial-mesenchymal transition, and modulating cell cycle dynamics. Efficient downregulation of survivin expression presents a promising strategy to enhance the antitumor effects of radiotherapy. Herein, we report the design of a hafnium-porphyrin-based cationic metal-organic layer (CMOL) with quaternary ammonium capping groups to deliver small interfering RNAs (siRNAs) for enhanced radiotherapy. The CMOL@siRNA nanoplatform not only increased energy deposition from X-rays and reactive oxygen species generation via a unique radiotherapy-radiodynamic therapy process, but also effectively delivered siRNAs to downregulate survivin expression and ameliorate radioresistance of cancer cells. Consequently, CMOL@siRNA in combination with low-dose X-ray irradiation demonstrated remarkable antitumor efficacy with 96.9 % and 91.4 % tumor growth inhibition in murine colorectal carcinoma and triple-negative breast cancer models, respectively.}, archive = {J_ANGEW}, author = {Xin Ma and Xiaomin Jiang and Zitong Wang and Yingjie Fan and Jinhong Li and Cathleen Chow and Chaoyu Wang and Chenghua Deng and Wenbin Lin}, doi = {10.1002/anie.202419409}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419409}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cationic metal-organic layer delivers siRNAs to overcome radioresistance and potentiate cancer radiotherapy}, volume = {64}, year = {2025}, }
• (2025). Stimulating the potential of zn anodes to operate in low pH and harsh environments forHighly sustainable zn batteries. ANGEW, 64(7), e202419394. (www)

  @article{ , abstract = {Compared to near-neutral electrolytes (pH=3–6), Zn||Mn batteries in acidic environments can achieve voltages up to ~2 V. However, high proton concentrations raise concerns about Zn anode stability. Current strategies for inhibiting hydrogen evolution corrosion (HEC) on the anode in Zn-based batteries mainly focus on the near-neutral electrolytes. To supplement this gap, we developed a conversion-type interphase strategy using phosphate, sulfate precipitation, and phytic acid modification layers for Zn anodes to demonstrate the potential of Zn anode to operate in acidic electrolytes. This approach enables stable Zn stripping/plating at pH=2.2 for over 3,600 h and 400 h at 1 mA cm −2 /0.5 mAh cm −2 and 20 mA cm −2 /10 mAh cm −2 . Benefiting from stable Zn electrodes, the electrolytic Zn||Mn batteries can operate at 1.90 V. To show more harsh scenarios, the seawater-based 0.25 Ah-scale Zn||Mn pouch cells can be assembled with a practical energy density of 57.4 Wh  kg-1 cell. Significantly, we analyze and emphasize that seawater holds promise as an alternative to deionized water for electrolyte solvents due to its energy and economic effectiveness. This strategy has motivated to expand the working pH range of metal anodes and provides the rational design for grid-scale energy storage technologies.}, archive = {J_ANGEW}, author = {Hang Yang and Li Li and Duo Chen and Jingyi Wang and Yicheng Tan and Zhenjing Jiang and Yiming Zhang and Chenglin Miao and Wei Zhang and Wei Han and Guanjie He}, doi = {10.1002/anie.202419394}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419394}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stimulating the potential of zn anodes to operate in low pH and harsh environments forHighly sustainable zn batteries}, volume = {64}, year = {2025}, }
• (2025). Metal-free electrocatalytic alkaline water splitting by porous macrocyclic proton sponges. ANGEW, 64(7), e202419377. (www)

  @article{ , abstract = {Macrocycles are unique as they encapsulate and transfer guest molecules or ions and facilitate catalytic processes. Although metalated macrocycles are pivotal in electrocatalytic processes, using metal-free analogs has been rare. Following the strategy of Kanbara et al., we synthesized an azacalixarene macrocycle- N , N’ , N’’ -tris( p -aminophenyl)azacalix[3](2,6)pyridine (CalixNH 2 ). The macrocycle encapsulates a proton in its cavity, maintaining the protonation even in highly alkaline media. Notably, it retains almost 50 % protonated form in 1 M KOH (~pH 14)-acting as a proton sponge. As hydrogen evolution is complex in alkaline media owing to sluggish water dissociation, we implemented the proton sponge (CalixNH 2 ) in an alkaline hydrogen evolution reaction. Conjugated Porous polymers, TpCalix and DhaCalix, have been synthesized from the triamine-CalixNH 2 . The most efficient catalyst, TpCalix, has shown excellent performance in alkaline HER and OER in 1 M KOH (~pH 14), with low overpotentials of only 112(±2) and 290(±2) mV at 10 mA cm −2 , respectively, and durable up to 24 hours. A full-cell reaction using TpCalix in both the cathode and anode exhibited a low full-cell voltage of 1.73 V and was stable for 12 hours. DFT calculations verified the tripyridinic core, which acts as the principal site for proton abstraction and binding.}, archive = {J_ANGEW}, author = {Ananda Basak and Arun Karmakar and Sayantani Dutta and Diptendu Roy and Satyadip Paul and Yusuke Nishiyama and Biswarup Pathak and Subrata Kundu and Rahul Banerjee}, doi = {10.1002/anie.202419377}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419377}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-free electrocatalytic alkaline water splitting by porous macrocyclic proton sponges}, volume = {64}, year = {2025}, }
• (2025). Methylthio substituent in SAM constructing regulatory bridge with photovoltaic perovskites. ANGEW, 64(7), e202419375. (www)

  @article{ , abstract = {Inverted (p-i-n) perovskite solar cells (PSCs) have experienced remarkable advancements in recent years, which is largely attributed to the development of novel hole-transport layer (HTL) self-assembled monolayer (SAM) materials. Methoxy (MeO−) groups are typically introduced into SAM materials to enhance their wettability and effectively passivate the perovskite buried interface. However, MeO-based SAM materials exhibit a mismatch in highest occupied molecular orbital (HOMO) levels with perovskite layer due to the strong electron-donating capability of methoxy group. In this work, we introduced a methylthio (MeS−) substituent that is superior to methoxy as a highly versatile self-assembled molecular design strategy. As a soft base, sulfur atom forms a stronger Pb−S bond than oxygen. Additionally, within the CbzPh series of SAM materials, MeS−CbzPh demonstrates a more optimal HOMO level and enhanced hole transport properties. Consequently, the MeS−CbzPh HTL based device achieved an impressive power conversion efficiency (PCE) of 26.01 % and demonstrated high stability, retaining 93.3 % efficiency after 1000 hours of maximum power point tracking (MPPT). Moreover, in comparison with the commonly used 4PACz-based SAM molecular series, MeS-4PACz also exhibited the best performance among its peers. Our work provides valuable insights for the molecular design of SAM materials, offering a highly versatile functional substituent group.}, archive = {J_ANGEW}, author = {Chun-Hao Chen and Gui-Wang Liu and Xin Chen and Caner Deger and Run-Jun Jin and Kai-Li Wang and Jing Chen and Yu Xia and Lei Huang and Ilhan Yavuz and Jian Fan and Zhao-Kui Wang}, doi = {10.1002/anie.202419375}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419375}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Methylthio substituent in SAM constructing regulatory bridge with photovoltaic perovskites}, volume = {64}, year = {2025}, }
• (2025). Suppression of structural heterogeneity in high-entropy intermetallics for electrocatalytic upgrading of waste plastics. ANGEW, 64(7), e202419369. (www)

  @article{ , abstract = {The key to fully realizing the potential of high-entropy alloys (HEAs) lies in balancing their inherent local chemical disordering with the long-range ordering required for electrochemical applications. Herein, we synthesized a distinctive L1 0 -(PtIr)(FeMoBi) high-entropy intermetallics (HEIs) exhibiting nanoscale long-range order and atomic scale short-range disorder via a lattice compensation strategy to mitigate the entropy reduction tendency. The (PtIr)(FeMoBi) catalyst exhibited remarkable activity and selectivity of glycollic acid (GA) production via electrocatalytic waste polymer-derived ethylene glycol oxidation reaction (EGOR). With a mass activity of 5.2 A mg Pt −1 and a Faradaic efficiency (FE) for GA of 95 %, it outperformed most previously reported electrocatalysts for selective GA production. The lattice-compensation effect promotes the homogeneity of Pt and Fe actives sites, facilitating co-adsorption of EG and OH and reducing the energy barriers for dehydrogenation and OH-combination processes. This approach effectively avoids the formation of low-active sites commonly encountered in HEA solid solutions, offering a promising avenue for exploring the complex interplay between catalytic activity and HEI structures.}, archive = {J_ANGEW}, author = {Jiace Hao and Tongde Wang and Jian Cai and Guohua Gao and Zechao Zhuang and Ruohan Yu and Jinsong Wu and Guangming Wu and Shuanglong Lu and Xiaofan Wang and Mingliang Du and Dingsheng Wang and Han Zhu}, doi = {10.1002/anie.202419369}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419369}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Suppression of structural heterogeneity in high-entropy intermetallics for electrocatalytic upgrading of waste plastics}, volume = {64}, year = {2025}, }
• (2025). Engineering d-p orbital hybridization in a single-atom-based solid-state electrolyte for lithium-metal batteries. ANGEW, 64(7), e202419367. (www)

  @article{ , abstract = {Regulating lithium salt dissociation kinetics by enhancing the interaction between inorganic fillers and lithium salts is vital for enhancing the ionic conductivity in solid-state composite polymer electrolytes (CPEs). However, the influence of fillers’ external electronic environments on lithium salt dissociation dynamics remains unclear. Here, we design single-atom sites in metal–organic framework fillers for poly(ethylene oxide) (PEO)-based CPEs, boosting lithium salt dissociation through an electrocatalytic strategy. This strategy enhances lithium-ion conductivity by tuning the coupling strength between the d and p orbitals of the fillers, as captured by a newly identified descriptor ( λ ) via high-throughput density functional theory (DFT) calculations and machine learning. The optimal single atom (Ti) sites are incorporated into a ZIF-8 matrix for PEO-based CPEs, achieving an ionic conductivity exceeding 10 −3 S cm −1 at 30 °C. Additionally, the electrolyte forms a robust solid electrolyte interphase and is compatible with LiCoO 2 , LiNi 0.9 Co 0.05 Mn0.05O 2 , and sulfur cathodes. Consequently, the solid-state lithium metal battery with the electrolyte demonstrates excellent cycling stability, maintaining performance over 5000 cycles at 10 C with LiFePO4 cathodes and stable operation at −30 °C. These findings highlight the transformative potential of engineering d - p orbital hybridization by incorporating single-atom sites into inorganic fillers for designing highly ion-conductive CPEs.}, archive = {J_ANGEW}, author = {Jiadong Shen and Junjie Chen and Xiaosa Xu and Jin Li and Zhenyu Wang and Yu Wang and Pengzhu Lin and Jing Sun and Baoling Huang and Tianshou Zhao}, doi = {10.1002/anie.202419367}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419367}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering d-p orbital hybridization in a single-atom-based solid-state electrolyte for lithium-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Modulating room-temperature phosphorescence of phenothiazine dioxide via external heavy atoms. ANGEW, 64(7), e202419366. (www)

  @article{ , abstract = {Developing pure organic materials with ultralong lifetimes and balanced quantum efficiency is attractive but challenging. In this study, we propose a novel strategy to investigate external heavy atoms by linking molecular emitters with halogen through a flexible alkyl chain. X-ray crystal analysis clearly reveal the halogen C−X-π interactions, which can be tuned by halogen donors, as well as the distance and geometry between them. Impressively, DOPTZ-C3Cl featuring a chloride atom as donor, exhibits a balanced long phosphorescence lifetime of 1351 ms and a phosphorescence quantum yield of 10.1 %. We also first demonstrate that Cl can induce more positive effect than heavier halogens (Br and I) on prolonging the lifetime. We envisage that the present study will expedite new molecular design to manipulate the room temperature phosphorescence via external heavy atom effect, and highlight a special C−Cl⋅⋅⋅π interaction for the development of ultralong phosphorescent materials.}, archive = {J_ANGEW}, author = {Heyang Li and Huili Ma and Peng Zhang and Zhongfu An and Xiaoming He}, doi = {10.1002/anie.202419366}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419366}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating room-temperature phosphorescence of phenothiazine dioxide via external heavy atoms}, volume = {64}, year = {2025}, }
• (2025). Using near-infrared irradiation for heating mechanochemical reactions in organic-dye-doped epoxy milling jars. ANGEW, 64(7), e202419354. (www)

  @article{ , abstract = {Albeit mechanochemistry is a novel promising technology that gives access to reactivity under solvent-free conditions, heating such reactions is sometimes compulsory to obtain satisfactory results in terms of conversion, selectivity and/or yield. In this work, we developed a novel approach using a dye that absorbs NIR photons and release the energy as heat. Hence, de novo milling jars in epoxy resin doped with the dye were thus produced to obtain reactors that would produce heat upon irradiation at 850 nm. Temperature profiles were recorded, depending on the irradiance, dye charge in the resin, and milling frequency, showing an excellent control of the temperature. The usefulness of the heating jar was then demonstrated in mechanochemical reactions that are known to require heat to yield the desired product, namely Diels–Alder reactions with high activation energies and the newly developed rearrangement of a sydnone into corresponding 1,3,4-oxadiazolin-2-one.}, archive = {J_ANGEW}, author = {Joao Tanepau and Hafsa Bonnaanaa and Angèle Macé and Arthur Guérin and Philibert Lenormand and Frédéric Lamaty and Julien Pinaud and Xavier Bantreil}, doi = {10.1002/anie.202419354}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419354}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Using near-infrared irradiation for heating mechanochemical reactions in organic-dye-doped epoxy milling jars}, volume = {64}, year = {2025}, }
• (2025). Pseudohalide anions driven structural modulation in distorted tetrahedral Manganese(II) hybrids toward tunable green-red emissions. ANGEW, 64(7), e202419333. (www)

  @article{ , abstract = {Mn(II)-based halides have recently garnered significant interest as emerging luminescence materials for diverse photonic applications. Generally, Mn(II) hybrids with tetrahedral coordination show green emission, however, ones with octahedral coordination give red emission. Herein, we design the synthesis of tetrahedral Mn(II) pseudohalide hybrids, (RPh 3 P) 2 MnBr x NCS 4−x (R=phenyl, pentyl or methyl; Ph 3 P=triphenylphosphine; x =1–3), achieved by gradually substituting bromides with pseudohalides (NCS − ). Compared to the green-emitting A 2 MnBr 4 (512 nm), the mixed hybrids exhibit significantly distorted [MnBr x NCS 4−X ] tetrahedra with high dipole moment, thus leading to the distinct Stokes shift energies and noticeable red shift emission in the range of 549–613 nm. Furthermore, the photoluminescence quantum yield (PLQY) of these hybrids correlates strongly with the pair correlation function of Mn(II) ions, specifically the Mn⋅⋅⋅Mn distance. These findings highlight the critical role of dipole moments in determining the emission properties and expand the luminescent family of Mn(II) pseudohalide hybrids.}, archive = {J_ANGEW}, author = {Shuai Zhang and Kai Han and Zhiguo Xia}, doi = {10.1002/anie.202419333}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419333}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pseudohalide anions driven structural modulation in distorted tetrahedral Manganese(II) hybrids toward tunable green-red emissions}, volume = {64}, year = {2025}, }
• (2025). Anti-stokes emission utilizing reverse intersystem crossing. ANGEW, 64(7), e202419323. (www)

  @article{ , abstract = {Photon-upconversion (PUC) processes in organic molecular systems, such as triplet-triplet upconversion and hot-band absorption, are promising technologies for future energy harvesting. Although these processes can generate high-energy excitons compared to excitation energy, a PUC process with a high yield and no energy loss has not been established and, therefore, is highly desired. Here, we propose an alternative PUC mechanism that uses reverse intersystem crossing on thermally activated delayed fluorescence (TADF) molecules. This process combines a triplet sensitizer and a TADF molecule, generating a triplet in the former and transferring it to the latter. Specifically, the triplet energy transfer from Ir(ppy) 3 (sensitizer) to CzBSe (TADF) results in anti-Stokes emission with an anti-Stokes energy of 0.18 eV. We found that the triplet energy transfer rate strongly depends on the triplet radiative decay rate of TADF molecules and the difference in Gibbs energy between the energy acceptor and donor. Our findings will contribute to understanding triplet energy transfer dynamics in organic energy donor-acceptor systems and will lead to various applications, such as future optical cooling systems.}, archive = {J_ANGEW}, author = {Shintaro Kohata and Hajime Nakanotani and Takuya Hosokai and Takuma Yasuda and Youichi Tsuchiya and Chihaya Adachi}, doi = {10.1002/anie.202419323}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419323}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anti-stokes emission utilizing reverse intersystem crossing}, volume = {64}, year = {2025}, }
• (2025). An interstitial boron inserted metastable hexagonal rh nanocrystal for efficient hydrogen oxidation electrocatalysis. ANGEW, 64(7), e202419320. (www)

  @article{ , abstract = {Constructing metastable phase structure plays an important role in changing the physicochemical properties and improving the catalytic performance of nanocrystals. Unfortunately, the synthesis of metastable phase metallic nanocrystals is highly challenging, mainly due to the thermodynamically unstable ground-state. Here, we report a synthesis of unconventional metastable hexagonal rhodium nanocrystal (B int −Rh hcp /C) via interstitial boron insertion. The insertion of boron atoms into the interstitial sites of cubic Rh lattice not only induces the atomic arrangements from face-centered cubic (fcc) to hexagonal close-packed (hcp), but also stabilizes the metastable hexagonal Rh structure. Benefiting from the phase transition and interstitial boron doping, the B int −Rh hcp /C catalyst exhibits remarkable catalytic performance toward hydrogen oxidation reaction (HOR) under alkaline media, with a mass activity of 1.413 mA μg PGM −1 . Experimental measurements including in situ surface-enhanced infrared absorption spectroscopy (SEIRAS) and density functional theory (DFT) calculations indicate that the strengthened adsorption of hydroxyl species on the electrode surface of B int −Rh hcp /C is responsible for the reconstruction of interfacial water structure and increased water proportions in the gap region in the electric double layers. As a result, the increased water connectivity and hydrogen bond network facilitate high-efficiency hydrogen transfer across the interface, thereby boost the alkaline HOR performance.}, archive = {J_ANGEW}, author = {Pengyu Han and Liqing Wu and Yu Zhang and Jianchao Yue and Yiming Jin and Hongnan Jia and Wei Luo}, doi = {10.1002/anie.202419320}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419320}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An interstitial boron inserted metastable hexagonal rh nanocrystal for efficient hydrogen oxidation electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Full conjugation in a polymer with non-conjugated piperazine-2,5-dione units via energy-minimized lactam-to-lactim tautomerization enables water-gated transistor fluoride sensors. ANGEW, 64(7), e202419314. (www)

  @article{ , abstract = {Piperazine-2,5-dione (glycine anhydride, GA) has recently emerged as a valuable precursor for high-performance π-conjugated polymer semiconductors in organic electronics. We utilized GA to design a novel bisindolin-dihydropiperazine (IDHP)-based conjugated polymer, PIDHPTT, for aqueous chemical sensing. In the isatin-flanked monomer, GA exists as a non-conjugated lactam (DHP-NH) but converts to a conjugated lactim (DHP-OH) form within the polymer. Density functional theory (DFT) calculations show that this conversion is driven by energy minimization via extended π-conjugation. Neighboring DHP units in the lactim form facilitate this process through π-bridges, demonstrating a vinylogous effect, which has previously only been observed in small molecules. This is the first study to report such a long-range vinylogous effect in a polymer due to the collective synergy of numerous functional groups. The OH groups in the lactim DHP interact more strongly with fluoride ions than other halides. PIDHPTT exhibits significant changes in optical absorption, electrochemical impedance, and charge transport in response to fluoride ions, which differ from responses to other halides. A water-gated organic field-effect transistor based on PIDHPTT shows excellent sensitivity and selectivity for fluoride ions, demonstrating the potential of this polymer design for chemical sensing applications.}, archive = {J_ANGEW}, author = {Naixin Zhao and Sung Jae Jeon and Yi Yuan and Samala Venkateswarlu and Andrew Stella and Jimmy Papazotos and Yuning Li}, doi = {10.1002/anie.202419314}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Full conjugation in a polymer with non-conjugated piperazine-2,5-dione units via energy-minimized lactam-to-lactim tautomerization enables water-gated transistor fluoride sensors}, volume = {64}, year = {2025}, }
• (2025). Self-adaptive coordination evolution mediated pore-space-partition in Metal–Organic frameworks for boosting SF6/N2 separation. ANGEW, 64(7), e202419302. (www)

  @article{ , abstract = {The controllable and precise structural regulation of metal–organic frameworks (MOFs) based on isoreticular chemistry is an effective strategy for creating functional material platforms, such as efficient porous adsorbents. Herein, for the first time, mediated by an unprecedented self-adaptive coordination evolution (SACE) on pseudo- D 2h -symmetric [M 4 ( μ 3 -O) 2 (COO) 6 ] (M=Mn/Fe) clusters, two pore space partitioned MOFs (CTGU-47-Mn/Fe, CTGU=China Three Gorges University) have been successfully constructed. Owing to the more confined adsorption space and dense binding sites produced by pore space partitioning (PSP), the CTGU-47-Mn/Fe exhibit significantly enhanced performance in the capture or recovery SF 6 (greenhouse/electronic specialty gas) from SF 6 /N 2 mixture compared to their non-partitioned homologous structures (CTGU-46-Mn/Fe) with adsorption selectivity increased from 37/72 to 634/157 (v/v, 10/90, 100 kPa). The theoretical calculations also elucidated that the implementation of PSP within CTGU-47-Mn/Fe leads to dramatically strengthened binding affinity for SF 6 over N 2 through extra multiple F⋅⋅⋅H interactions. This study represents a valuable advance in crystal engineering field: the SACE of polynuclear metal clusters is expected to be useful in the structural regulation of MOFs and the fabrication of advanced porous adsorbents.}, archive = {J_ANGEW}, author = {Heng-Yu Ruan and Xue-Qian Wu and Cai-Lian Liao and Meidi Wang and Ya-Pan Wu and Guangtong Hai and Xiang Zhao and Dong-Sheng Li}, doi = {10.1002/anie.202419302}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419302}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-adaptive coordination evolution mediated pore-space-partition in Metal–Organic frameworks for boosting SF6/N2 separation}, volume = {64}, year = {2025}, }
• (2025). Negative thermal expansion behavior enabling good electrochemical-energy-storage performance at low temperatures. ANGEW, 64(7), e202419300. (www)

  @article{ , abstract = {Metal-ion batteries (such as lithium-ion batteries) are very popular energy-storage devices nowadays. However, low temperatures cause their poor electrochemical kinetics and performance, significantly limiting their wide applications in cold environments. Here, we propose that electrochemical energy-storage materials with negative-thermal-expansion (NTE) behavior can enable good low-temperature electrochemical performance, which becomes a new strategy to tackle the low-temperature issues of metal-ion batteries. LiTi 2 (PO 4 ) 3 (LTP) with an a -direction thermal expansion coefficient of −1.1×10 − K −1 is used as a model material. As the temperature decreases, the transverse vibration of O atoms not only increases the transverse distances among O atoms connected to Li/Ti atoms, but also widens the Li + -transport channels and enlarges the Li + -insertion sites along the [12 ] direction, which are mainly controlled by the lattice parameter a . Consequently, carbon-coated LTP (C–LTP) retains good electrochemical performance at −10 °C, including fast Li + diffusivity (84 % of that at 25 °C), large capacity (96 % of the theoretical capacity), and superior rate capability (83 % capacity retention at 5 C vs. 0.5 C). Moreover, the more open crystal structure of LTP at the lower temperature allows smaller maximum unit-cell-volume expansion, resulting in better cycling stability of C–LTP at −10 °C (96.8 % capacity retention over 1000 cycles at 2 C).}, archive = {J_ANGEW}, author = {Qiao Li and Liting Yang and Guisheng Liang and Jiahui Yu and Shaowu Huang and Liming Wu and Chunfu Lin and Renchao Che}, doi = {10.1002/anie.202419300}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419300}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Negative thermal expansion behavior enabling good electrochemical-energy-storage performance at low temperatures}, volume = {64}, year = {2025}, }
• (2025). Programmable modular assembly of homochiral Ir(III)-metallohelices to reverse metallodrug resistance by inhibiting CDK1. ANGEW, 64(7), e202419292. (www)

  @article{ , abstract = {Drug resistance is a major cause of cancer recurrence and poor prognosis. The innovative design and synthesis of inhibitors to target drug-resistance-specific proteins is highly desirable. However, challenges remain in precisely adjusting their conformation and stereochemistry to adapt the chiral regions of target proteins. Herein, using a stepwise programmable modular assembly approach, we precisely engineered two pairs of homochiral dinuclear Ir(III) metallohelices ( Λ 2 S 4 -H bpy and Δ 2 R 4 -H bpy , Δ 2 S 4 -H bpy and Λ 2 R 4 -H bpy ) functionalized with flexible dithiourea linkages. The resulting homochiral metallohelices exhibited significant chirality-dependent photocytotoxicities, and the enhanced structural compatibility of Δ 2 S 4 -H bpy with the target cyclin-dependent kinase 1 (CDK1) contributed to its superior photodynamic therapy efficacy, achieving an outstanding photocytotoxicity index (PI) value of 2.3×10 4 . Interestingly, emerging as a critical mediator in the development of oxaliplatin resistance, CDK1 targeting by Δ 2 S 4 -H bpy achieved enhanced cellular uptake, anticancer activity, and oncosis-mediated cell death in oxaliplatin-resistant HCT-8/L cells. Mechanistic investigations, including proteomic profiling and CDK1 gene silencing, confirmed the pivotal role of chirality-selective CDK1 targeting in reversing metallodrug resistance. This study introduces a promising platform for constructing and customizing flexible metallohelices with precise conformation and stereochemistry to target drug-resistance-specific proteins, offering innovative insights into the designability of metallodrugs to overcome drug resistance.}, archive = {J_ANGEW}, author = {Xuezhao Li and Xing Zhao and Xingyun Wang and Anxian Xiong and Zhicheng Wang and Zhuolin Shi and Jingyi Zhang and Hanlin Wang and Wei Wei and Cheng He and Jiajia Ma and Zijian Guo and Chunying Duan and Jing Zhao and Xiuxiu Wang}, doi = {10.1002/anie.202419292}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419292}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programmable modular assembly of homochiral Ir(III)-metallohelices to reverse metallodrug resistance by inhibiting CDK1}, volume = {64}, year = {2025}, }
• (2025). Harnessing of cooperative Cu⋅⋅⋅H interactions for luminescent low-coordinate Copper(I) complexes towards stable OLEDs. ANGEW, 64(7), e202419290. (www)

  @article{ , abstract = {Although two-coordinate Cu(I) complexes are highly promising low-cost emitters for organic light-emitting diodes (OLEDs), the exposed metal center in the linear coordination geometry makes them suffer from poor stability. Herein, we describe a strategy to develop stable carbene-Cu-amide complexes through installing intramolecular noncovalent Cu⋅⋅⋅H interactions. The employment of 13H-dibenzo[a,i]carbazole (DBC) as the amide ligand leads to short Cu⋅⋅⋅H distances in addition to the Cu−N coordination bond. The resultant Cu(I) complexes exhibit yellow thermally activated delayed fluorescence with photoluminescence quantum yields of up to 86 % and radiative decay rate constants on the order of 10 6 s −1 . Comparing with the analogues without Cu⋅⋅⋅H interactions, the pincer complexes have significantly improved stability. The vacuum-deposited OLEDs show high-performance electroluminescence with maximum external quantum efficiencies of up to 29.5 % and extremely small roll-offs of only 3.5 % at 10,000 cd m −2 . Remarkably, the operational lifetimes (LT 90 ) are up to 68 h with an initial luminance of 3000 cd m −2 . This work proves a feasible design of robust low-coordinate metal complexes by leveraging secondary coordination interactions, which helps to overcome the long-standing stability problem.}, archive = {J_ANGEW}, author = {Qizheng Zhang and Nengquan Li and Xintong Wan and Xiu-Fang Song and Yi Zhang and He Liu and Jingsheng Miao and Yang Zou and Chuluo Yang and Kai Li}, doi = {10.1002/anie.202419290}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419290}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing of cooperative Cu⋅⋅⋅H interactions for luminescent low-coordinate Copper(I) complexes towards stable OLEDs}, volume = {64}, year = {2025}, }
• (2025). Bowl-shaped anthracene-fused antiaromatic Ni(II) norcorrole: Synthesis, structure, assembly with c60, and photothermal conversion. ANGEW, 64(7), e202419289. (www)

  @article{ , abstract = {The synthesis of bowl-shaped antiaromatic molecules is challenging because the molecular distortion further destabilizes these already inherently reactive molecules. Here, we report the synthesis and properties of bowl-shaped fused anthrylnorcorroles that exhibit near-infrared (NIR) absorption reaching 1900 nm. The oxidation of meso -anthryldibromodipyrrin provides fused anthryldibromodipyrrin, which was converted to the fused mono- and bisanthrylnorcorroles through Ni(0)-mediated intramolecular coupling with a bis(dibromodipyrrin) Ni(II) complex. Single-crystal X-ray diffraction analyses revealed bowl-shaped structures for the fused mono- and bisanthrylnorcorroles, which enables them to act as suitable receptors for C 60 with bonding constants of 2.89×10 3 M −1 and 1.59×10 3 M −1 , respectively. The formation of a 1 : 1 complex between the fused monoanthrylnorcorrole and C 60 was confirmed by single-crystal X-ray diffraction analysis. The effective expansion of the π-conjugation through the triple fusion of the norcorrole with the anthracene units substantially enhances the near-infrared absorption bands, which endows these anthrylnorcorroles with effective photothermal conversion.}, archive = {J_ANGEW}, author = {Kaisheng Wang and Aninda Ghosh and Daiki Shimizu and Hideaki Takano and Masatoshi Ishida and Ryohei Kishi and Hiroshi Shinokubo}, doi = {10.1002/anie.202419289}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419289}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bowl-shaped anthracene-fused antiaromatic Ni(II) norcorrole: Synthesis, structure, assembly with c60, and photothermal conversion}, volume = {64}, year = {2025}, }
• (2025). Efficient photocatalytic CH4-to-ethanol conversion by limiting interfacial hydroxyl radicals using gold nanoparticles. ANGEW, 64(7), e202419282. (www)

  @article{ , abstract = {Photocatalytic CH 4 oxidation to ethanol with high selectivity is attractive but substantially challenging. The activation of inert C−H bonds at ambient conditions requires highly reactive oxygen species like hydroxyl radicals (⋅OH), while the presence of those oxidative species also facilitates fast formation of C 1 products, instead of the kinetically sluggish C−C coupling to produce ethanol. Herein, we developed a BiVO 4 photocatalyst with surface functionalization of Au nanoparticles (BiVO 4 @Au), which not only enables photogeneration of ⋅OH to activate CH 4 into ⋅CH 3 , but also in situ consumes those ⋅OH species to retard their further attack on ⋅CH 3 , resulting in an enhanced ⋅CH 3 /⋅OH ratio and facilitating C−C coupling toward ethanol. The ⋅CH 3 /⋅OH ratio is further improved by transporting CH 4 via a gas-diffusion layer to the photocatalytic interface, leading to even higher ethanol selectivity and production rates. At ambient conditions and without photosensitizers or sacrificial agents, the BiVO 4 @Au photocatalyst exhibited an outstanding CH 4 -to-ethanol conversion performance, including a peak ethanol yield of 680 μmol ⋅ g −1 ⋅ h −1 , a high selectivity of 86 %, and a stable photoconversion of >100 h, substantially exceeding most of the previous reports. Our work suggests an attractive approach of in situ generation and modulation of the ⋅OH levels for photocatalytic CH 4 conversion toward multi-carbon products.}, archive = {J_ANGEW}, author = {Quan Zhang and Chao Yang and Yangshen Chen and Yaqin Yan and Miao Kan and Huining Wang and Ximeng Lv and Qing Han and Gengfeng Zheng}, doi = {10.1002/anie.202419282}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419282}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient photocatalytic CH4-to-ethanol conversion by limiting interfacial hydroxyl radicals using gold nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Semiconductive coordination polymer with multi-channel charge transfer for high-performance direct X-ray detection. ANGEW, 64(7), e202419266. (www)

  @article{ , abstract = {Coordination polymers (CPs) are promising for direct X-ray detection and imaging owing to higher designability and outstanding stability, however, it remains a challenge to achieve highly X-ray detection performance, particularly both high sensitivity and low detection limit at the same operating voltage. Herein, we construct a new conjugated CP {[Co(BPTTz)(DIPA)] ⋅ DMA} n ( 1 , BPTTz=2,5-bis(pyridine-4-yl)thiazolo[5,4- d ]thiazole, H 2 DIPA=2,5-diiodoterephthalic acid, DMA= N , N’ -dimethylacetamide), with multi-channel charge transfer by regulating the linker mediated electronic-state, which reduces carrier losses resulting from recombination or quenching, enhances the efficiency of charge separation and transfer, thus further optimizes X-ray detection performance. The semiconductor prepared based on this strategy achieves record values including the highest mobility-lifetime product ( μτ , 8.05×10 −3 cm 2 V −1 ) and the lowest detectable X-ray dose rate (128 nGy air S −1 , 35 V) among CP-based direct radiation detectors, as well as a high sensitivity (172 μC Gy air −1 cm −2 , 35 V) at the same operating voltage. This detector shows excellent long-time air stability under ambient conditions for over three months and operational stability. These findings demonstrate a rational structural design method to enhance the photoelectronic efficiency and stability of semiconductive CPs.}, archive = {J_ANGEW}, author = {Xiao-Qing Yu and Li-Bo Sun and Qing-Yi Li and Bo-Lun Wang and Ming-Sheng Wang and Ji-Yang Li and Guo-Cong Guo and Ji-Hong Yu}, doi = {10.1002/anie.202419266}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419266}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Semiconductive coordination polymer with multi-channel charge transfer for high-performance direct X-ray detection}, volume = {64}, year = {2025}, }
• (2025). Freestanding phosphonium covalent organic frameworks with efficient hydroxide conduction for Zinc–Air batteries. ANGEW, 64(7), e202419257. (www)

  @article{ , abstract = {Owing to their well-defined crystalline pore structures and ordered functional ionic groups along the skeleton, ionic covalent organic frameworks (iCOFs) exhibit excellent performance and have significant potential for use in energy storage and conversion devices. Herein, we for the first time developed cationic phosphonium COFs with high hydroxide conduction even with low ion exchange capacity (IEC). Specifically, we synthesized COFs containing quaternary phosphonium groups as excellent ion transport moieties. Then, we fabricated freestanding phosphonium membranes through a vapor-assisted method, which exhibited high hydroxide conductivity of 126 mS cm −1 at 80 °C from a minimal IEC of 1.17 mmol g −1 . The resulting film was successfully applied to zinc–air batteries, demonstrating energy density of 96.1 mW cm −2 , specific capacity of 95.0 mAh cm −2 , and stable operation over 2,300 min. Overall, in addition to investigating a novel cationic functional group, we demonstrated a freestanding film formation method of COF-based materials. The findings can provide a solid foundation for advancing the field of iCOFs to ion transport and promoting electrochemical applications.}, archive = {J_ANGEW}, author = {Ye Tian and Xiaobin Hui and Kaiyu Wang and Yufei Yuan and Huanhuan Chen and Ki-Taek Bang and Ran Tao and Rui Wang and Dong-Myeong Shin and Yaozhong Lan and Zheng-Long Xu and Yoonseob Kim}, doi = {10.1002/anie.202419257}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419257}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Freestanding phosphonium covalent organic frameworks with efficient hydroxide conduction for Zinc–Air batteries}, volume = {64}, year = {2025}, }
• (2025). Thermal bistability of magnetic susceptibility, light absorption, second harmonic generation, and dielectric properties in a polar spin-crossover Iron–Rhenium chain material. ANGEW, 64(7), e202419242. (www)

  @article{ , abstract = {The bistability of multiple physical properties driven by external stimuli in a solid is a desired prerequisite for its application in memory devices with convenient data readout. We present a pathway for thermal bistability detectable in four physical properties: magnetic, light absorption, second-harmonic generation (SHG), and dielectric. We report a novel heterometallic (TBA){[Fe II (phIN) 4 ][Re V (CN) 8 ]} ⋅ (phIN) ( 1 ) (TBA=tetrabutylammonium cation, phIN=phenyl isonicotinate) cyanido-bridged chain material. Owing to an appropriate {N 6 } coordination sphere of Fe(II) centers, 1 reveals a thermal spin crossover (SCO) effect which is complete and cooperative providing a distinct thermal hysteresis loop in magnetic measurements. Moreover, it exhibits simultaneous thermal bistability in (a) visible-light absorption due to the presence of efficient d-d electronic transitions in the low-spin (LS) state, (b) SHG activity as it crystallizes in a polar C c space group due to the bulky substituent on phIN ligands, and (c) dielectric parameters, including dielectric constant, which can be correlated with subtle changes in polarity between LS and HS (high spin) phases. Thus, we present a remarkable thermally controlled hysteretic behavior in four physical functionalities realized by properly functionalizing an SCO-active coordination compound.}, archive = {J_ANGEW}, author = {Tomasz Charytanowicz and Junhao Wang and Hiroko Tokoro and Kevin Tran and Franz Renz and Shin-ichi Ohkoshi and Szymon Chorazy and Barbara Sieklucka}, doi = {10.1002/anie.202419242}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419242}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermal bistability of magnetic susceptibility, light absorption, second harmonic generation, and dielectric properties in a polar spin-crossover Iron–Rhenium chain material}, volume = {64}, year = {2025}, }
• (2025). Quinoline substituted anthracene isomers: A case study for simultaneously optimizing high mobility and strong luminescence in herringbone-packed organic semiconductors. ANGEW, 64(7), e202419213. (www)

  @article{ , abstract = {The development of high mobility emissive organic semiconductors is significant for advancing optoelectronic devices with simplified architecture and enhanced performance. The herringbone-packed structure is regarded as the ideal arrangement for simultaneously achieving high mobility and strong emission in organic semiconductors. However, it remains a great challenge that the relationship between molecular structure and optoelectronic property is still elusive. Herein, four quinoline-substituted anthracene isomers were designed and synthesized by introducing quinoline groups to anthracene core. Their intermolecular interactions and packing mode in the herringbone-packed structures were regularly tuning by subtle changing the nitrogen position on quinoline group, resulting in the superior integration of optoelectronic properties. Through a comprehensive analysis of aggregation states and optoelectronic properties, we revealed that in herringbone-packed aggregates, a centroid distance of approximately 7–7.5 Å along CH-π direction and 6–6.5 Å along π–π direction is beneficial for simultaneously achieving high mobility and strong emission. These properties are closely related to the molecular twist angles, which are influenced by intramolecular interactions. This structure–property relationship has been further validated in other herringbone-packed high mobility emissive organic semiconductors, demonstrating its broad applicability and universal potential. This work figures out the practical molecular design principle for high mobility emissive organic semiconductors.}, archive = {J_ANGEW}, author = {Pu Wang and Can Gao and Zhenjie Ni and Dan Liu and Yihan Zhang and Zhenling Liu and Yumin Liu and Wenping Hu and Huanli Dong}, doi = {10.1002/anie.202419213}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419213}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quinoline substituted anthracene isomers: A case study for simultaneously optimizing high mobility and strong luminescence in herringbone-packed organic semiconductors}, volume = {64}, year = {2025}, }
• (2025). Photoinduced Energy/Electron transfer within single-chain nanoparticles. ANGEW, 64(7), e202419205. (www)

  @article{ , abstract = {We demonstrate that single-chain nanoparticles (SCNPs) – compact covalently folded single polymer chains – can increase photocatalytic performance of an embedded catalytic center, compared to the comparable catalytic system in free solution. In particular, we demonstrate that the degree of compaction allows to finely tailor the catalytic activity, thus evidencing that molecular confinement is a key factor in controlling photocatalysis. Specifically, we decorate a linear parent polymer with both photoreactive chalcone moieties as well as Ru(bpy) 3 catalytic centers. We initially construct a SCNP via a photosensitized [2+2] cycloaddition at 510 nm and demonstrate that the SCNP formation is substantially more efficient when the Ru(bpy) 3 units are part of the polymer chain instead of as free molecules in solution. Subsequently, we employ the same Ru(bpy) 3 units as photocatalysts in a model reaction employing pyrene units as charge transfer moieties. We establish that the photocatalytic activity increases as the polymer becomes more compact, reaching peak efficiency, followed by a subsequent decline as the SCNP becomes too compact. Thus, we identify a goldilocks regime of catalyst confinement via SCNP compaction for use in photocatalysis.}, archive = {J_ANGEW}, author = {Masanori Nagao and Kai Mundsinger and Christopher Barner-Kowollik}, doi = {10.1002/anie.202419205}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419205}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoinduced Energy/Electron transfer within single-chain nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Energy-level alignment at TiO2@NH2-MIL-125 interface for high-performance gas sensing. ANGEW, 64(7), e202419195. (www)

  @article{ , abstract = {Metal oxide (MO)-based chemiresistive sensors have great potential in environmental monitoring, security protection, and disease diagnosis. However, the thermally activated sensing mechanism in pristine MOs leads to high working temperature and poor selectivity, which are the main challenges impeding practical applications. Precise modulation of the band structure at the heterojunction interfaces of MOs offers the opportunity to unlock unique electrical and optical properties, enabling us to overcome these challenges. Metal–organic frameworks (MOFs) with tunable structures are promising materials for aligning the energy levels at the heterojunctions of MOs. Herein, we report the energy-level structural engineering of MO@MOF heterojunctions to optimize chemiresistive sensing performance. The interface was flexibly modulated from a straddling gap to a staggered gap by -NH 2 functionalization of TiO 2 @(NH 2 ) x -MIL-125, varying x from 0 to 1 and 2, respectively. TiO 2 @(NH 2 ) x -MIL-125 combines the advantages of MOs and MOFs to synergistically improve gas-sensing properties. As a result, TiO 2 @NH 2 -MIL-125 is the first light-activated material to detect NO 2 at 1 ppb with a response time of < 0.3 min at room temperature. It also exhibited excellent selectivity and long-term stability. Our study underscores the potential of energy band engineering in creating high-performance sensors, offering a strategy to overcome current material limits.}, archive = {J_ANGEW}, author = {Wei-Hua Deng and Min-Yi Zhang and Chun-Sen Li and Ming-Shui Yao and Gang Xu}, doi = {10.1002/anie.202419195}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419195}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Energy-level alignment at TiO2@NH2-MIL-125 interface for high-performance gas sensing}, volume = {64}, year = {2025}, }
• (2025). Metabolic Acidity/H2O2 dual-cascade-activatable molecular imaging platform toward metastatic breast tumor malignancy. ANGEW, 64(7), e202419191. (www)

  @article{ , abstract = {Fluorescence imaging in the second near-infrared window (NIR-II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR-II probes are limited by either being “always on” or responding to one stimulus, leading to low signal-to-noise ratios and potential false positives. We introduced a dual-lock-controlled probe, HN-PBA , activated by both H 2 O 2 and tumor acidic environment. This dual response ensures bright fluorescence at tumor sites, leading to higher tumor-to-normal tissue ratios (T/NT) compared to conventional “always on” probes and probes activated only by H 2 O 2 . This strategy allows precise tumor identification and removal of primary and metastatic tumors, achieving superior T/NT ratios (24.3/6.4 for orthotopic and lung metastasis, respectively). Our probe also effectively detected lung metastatic foci as small as≤0.7 mm and showed the capability for accurate lesion localization in clinical breast cancer specimens. This dual-stimuli-responsive strategy could aid future diagnostic probe design.}, archive = {J_ANGEW}, author = {Kun Dou and Jiao Lu and Yanlong Xing and Rui Wang and Miae Won and Jungryun Kim and Fabiao Yu and Jong Seung Kim}, doi = {10.1002/anie.202419191}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419191}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metabolic Acidity/H2O2 dual-cascade-activatable molecular imaging platform toward metastatic breast tumor malignancy}, volume = {64}, year = {2025}, }
• (2025). Halogen radical-activated perovskite-substrate buried heterointerface for achieving hole transport layer-free tin-based solar cells with efficiencies surpassing 14 %. ANGEW, 64(7), e202419183. (www)

  @article{ , abstract = {Sn-based perovskites have emerged as one of the most promising environmentally-friendly photovoltaic materials owing to their low toxicity and exceptional optoelectronic properties. Nonetheless, the low-cost production and stable operation of Sn-based perovskite solar cells (PSCs) are still largely limited by the costly hole transport materials and the under-optimized interfaces between hole transport layer (HTL) and Sn perovskite layer. Here, we innovatively developed a chlorine radical chemical bridging (Cl-RCB) strategy that enabled to remove the HTL and optimize the indium tin oxide (ITO)/perovskite heterointerface for constructing high-performance Sn-based PSCs with simplified structures. The key is to modify the commercially-purchased ITO electrode with highly active chlorine radicals that could effectively mitigate the surface oxygen vacancies, alter the chemical constitutions, and favorably down-shifted the work function of ITO surface to be close to the valence band of perovskites. As a result, the interfacial energy barrier has been largely reduced by 0.20 eV and the interfacial carrier dynamics have been optimized at the ITO/perovskite heterointerface. Encouragingly, the efficiency of HTL-free Sn-based PSCs has been enhanced from 6.79 % to 14.20 %, which is on par with the state-of-the-art conventional HTL-containing counterparts (normally >14 % efficiency) and representing the record performance for the Sn perovskite photovoltaics in the absence of HTL. Notably, the target device exhibited enhanced stability for up to 2000 h. The Cl-RCB strategy is also versatile to be used in Pb-based and mixed Sn−Pb HTL-free PSCs, achieving efficiencies of 22.27 % and 21.13 %, respectively, all representing the advanced device performances for the carrier transport layer-free PSCs with simplified device architectures.}, archive = {J_ANGEW}, author = {Gengling Liu and Xianyuan Jiang and Yaorong He and Chun-Hsiao Kuan and Guo Yang and Wenhuai Feng and Xi Chen and Wu-Qiang Wu}, doi = {10.1002/anie.202419183}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogen radical-activated perovskite-substrate buried heterointerface for achieving hole transport layer-free tin-based solar cells with efficiencies surpassing 14 %}, volume = {64}, year = {2025}, }
• (2025). Modulating the coverage of adsorbed hydrogen via hydrogen spillover enables selective electrocatalytic hydrogenation of phenol to cyclohexanone. ANGEW, 64(7), e202419178. (www)

  @article{ , abstract = {Selective electrocatalytic hydrogenation (ECH) of phenol is a sustainable route to produce cyclohexanone, an industrially important feedstock for polymer synthesis. However, attaining high selectivity and faradaic efficiency (FE) for cyclohexanone remain challenging, owning to over-hydrogenation of phenol to cyclohexanol and competition of hydrogen evolution reaction (HER). Herein, by employing hydrogen spillover effect, we modulate adsorbed hydrogen species (H ads ) coverage on Pt surface via migration to TiO 2 in an anatase TiO 2 -supported Pt catalyst. In ECH of phenol, a high selectivity (94 %) and good FE (63 %) for cyclohexanone are obtained, showing more advantageous performance compared with previous reports. Cyclic voltammetry (CV) tests and electrochemical Raman spectroscopy reveal that H ads migrated from Pt to TiO 2 . We propose that TiO 2 -induced hydrogen spillover contributes to low H ads coverage over Pt, which effectively hinders over-hydrogenation of cyclohexanone and HER. We establish a scaling relationship between the intensity of hydrogen spillover and cyclohexanone selectivity by varying the types of anatase TiO 2 , and show the universality of the strategy over other reducible metal oxides as the support (rutile TiO 2 , CeO 2 and WO 3 ). This work showcases an effective strategy for tuning hydrogenation selectivity in electro-catalysis, by taking advantage of thermo-catalytically well-documented hydrogen spillover effect.}, archive = {J_ANGEW}, author = {Yuanbo Liu and Kaiyue Ji and Xi Wang and Qiujin Shi and An-Zhen Li and Zhuoqun Yin and Yu-Quan Zhu and Haohong Duan}, doi = {10.1002/anie.202419178}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419178}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating the coverage of adsorbed hydrogen via hydrogen spillover enables selective electrocatalytic hydrogenation of phenol to cyclohexanone}, volume = {64}, year = {2025}, }
• (2025). The amplification of alpha-synuclein amyloid fibrils is suppressed under fully quiescent conditions. ANGEW, 64(7), e202419173. (www)

  @article{ , abstract = {Seed amplification assays (SAAs) are a promising avenue for the early diagnosis of neurodegenerative diseases. However, when amplifying fibrils from patient-derived samples in multiwell plates, it is currently highly challenging to accurately quantify the aggregates. It is therefore desirable to transfer such assays into a digital format in microemulsion droplets to enable direct quantification of aggregate numbers. To achieve transfer from conventional plate-based to the microfluidic digital format, effective seed amplification needs to be achieved inside the microdroplets. Therefore, we establish a new set of assay conditions that enable highly efficient seed amplification in plates without any shaking. However, the same set of conditions displayed a very different behavior upon transfer to a microfluidic platform where no amplification was observed. We demonstrate that this is caused by the suppression of all secondary processes that could amplify the seeds in the complete absence of mechanical perturbations inside the microdroplets. We further show that the amplification inside droplets can be achieved by subjecting the microemulsions to high-frequency vibrations using a piezo device. Taken together, our results provide novel insights into the physical requirements of alpha-synuclein seed amplification and demonstrate a pathway towards the development of effective digital SAAs.}, archive = {J_ANGEW}, author = {Azad Farzadfard and Thomas O. Mason and Antonin Kunka and Hossein Mohammad-Beigi and Kaare Bjerregaard-Andersen and Jonas Folke and Susana Aznar and Pekka Kallunki and Alexander K. Buell}, doi = {10.1002/anie.202419173}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419173}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The amplification of alpha-synuclein amyloid fibrils is suppressed under fully quiescent conditions}, volume = {64}, year = {2025}, }
• (2025). Visible light excitation of poly-(para-phenylene ethynylene) enables heterogeneous photocatalytic oxidations of amines in flow. ANGEW, 64(7), e202419169. (www)

  @article{ , abstract = {Heterogeneous visible light photocatalysis is a compelling approach to address sustainability in synthetic photochemistry. However, the use of solid-state photocatalysts remains very unpopular in organic synthesis because of their limited accessibility and the black-box effect associated to the lack of rational between their molecular structure and their photochemical properties. Herein, we disclose the synthesis, characterization, photocatalytic properties and synthetic applications of a simple and readily available solid-state conjugated organic polymer, poly-( para -phenylene ethynylene) 1 , which exhibits a strong oxidative power upon irradiation with visible light (E( 1* / 1 ⋅ − )=+1.67 V vs SCE). Comparisons with structural analogues highlighted the superior photocatalytic activity of this linear semiconductor, on account of its fully conjugated architecture. The associated excited-state reactivity enabled the transformation of various amines into imines in batch and continuous flow reactors together with straightforward photocatalyst recycling. Mechanistic investigations revealed concomitant photoredox and energy transfer pathways, that led to the formation of the desired products. Ultimately, the inline generation of imines was exploited in telescoped three-component Ugi reactions (3CR) in batch and flow toward biologically relevant α-acylaminoamides.}, archive = {J_ANGEW}, author = {Basile Weyl and Gabriel Goujon and Lucas Raggio and Emmanuelle Demey and Joelle Vinh and Jean-Baptiste d'Espinose de Lacaillerie and Jean-Marc Krafft and Benjamin Laroche}, doi = {10.1002/anie.202419169}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible light excitation of poly-(para-phenylene ethynylene) enables heterogeneous photocatalytic oxidations of amines in flow}, volume = {64}, year = {2025}, }
• (2025). Azopyridine polymers in organic phase change materials for high energy density photothermal storage and controlled release. ANGEW, 64(7), e202419165. (www)

  @article{ , abstract = {Azo-compounds molecules and phase change materials offer potential applications for sustainable energy systems through the storage and controllable release photochemical and phase change energy. Developing novel and highly efficient Azo-based solar thermal fuels (STFs) for photothermal energy storage and synergistic cooperation with organic phase change materials present significant challenges. Herein, three types of ( ortho -, meta -, and para -) azopyridine polymers hinged with flexible alkyl chain are synthesized, in which meta -azopyridine polymer exhibits striking photothermal storage capacity of 430 J/g, providing a feasibility solution for developing high energy density Azo-based STFs. Furthermore, a stable two-phase hybrid system was innovatively constructed by combining the meta -azopyridine polymer with organic phase change materials leveraging hydrogen bonds and van der Waals interactions to collectively harness phase change energy and photothermal energy. The organic phase change material not only supplies additional phase change latent heat but also serves as a solvent, offering abundant free volume for the photo-induced isomerization of the azopyridine chromophores, which successfully circumvents the low charging efficiency in the condensed state and reliance on solvent-assisted charging in traditional Azo-based STFs. This study demonstrates the energy distribution and utilization for household consumers and the photothermal-assisted insulation strategy, achieving more extensive potential implementation for STFs.}, archive = {J_ANGEW}, author = {Rihui Liang and Bo Yuan and Fei Zhang and Wei Feng}, doi = {10.1002/anie.202419165}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419165}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Azopyridine polymers in organic phase change materials for high energy density photothermal storage and controlled release}, volume = {64}, year = {2025}, }
• (2025). Palladium-catalyzed, regio-/Stereo- and enantiospecific anti-carboxylation of unactivated internal allenes. ANGEW, 64(7), e202419127. (www)

  @article{ , abstract = {We report herein a directing group-controlled, palladium-catalyzed, regio-, stereo-, and enantiospecific anti -carboxylation of unactivated, internal allenes enabled via the synergistic interplay of a rationally designed bidentate directing group, palladium catalyst, and a multifunctional acetate ligand. The corresponding trans allyl ester was obtained in excellent yields with exclusive δ-regioselectivity and anti -carboxypalladation stereocontrol. The acetate ligand of the palladium catalyst controls the regio-, stereo- and enantioselectivity in the desired transformation. The potential of this concept has been demonstrated by the development of the chiral version of this transformation by using axial-to-central chirality transfer with good yields and enantioselectivities. Detailed investigations, including kinetic studies, order studies, and DFT studies, were performed to validate the ligand-assisted nucleopalladation process and the rationale behind the observed racemization of chiral allenes. The studies also indicated that the anti -carboxypalladation step was the rate-limiting as well as the stereo- and enantiodetermining step.}, archive = {J_ANGEW}, author = {Prajyot Jayadev Nagtilak and Deveen Rajeshbhai Hirapara and Manoj V. Mane and Akshat Jain and Manmohan Kapur}, doi = {10.1002/anie.202419127}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419127}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Palladium-catalyzed, regio-/Stereo- and enantiospecific anti-carboxylation of unactivated internal allenes}, volume = {64}, year = {2025}, }
• (2025). Strong metal-support interaction between pt and TiO2 over high-temperature CO2 hydrogenation. ANGEW, 64(7), e202419103. (www)

  @article{ , abstract = {The catalytic activities and stability of oxide-supported metal catalysts are significantly affected by metal-support interactions (MSI) between oxidic supports and supported metals. The surface properties of the support, such as its phase and defects, are crucial in MSI, including both the strong metal-support interaction (SMSI) and electronic metal-support interaction (EMSI). In this study, modulation of SMSI was achieved on rutile-supported Pt nanoparticles (NP) over high-temperature CO 2 hydrogenation. The encapsulation of Pt NP surfaces with TiO 2– x overlayers is precisely controlled by the defects. It is found that oxygen vacancy defects significantly enhance the catalytic stability of Pt/rutile under high-temperature reverse water-gas shift (RWGS) reaction by inhibiting the occurrence of SMSI. Pt/rutile with oxygen vacancies achieves a 301 mol CO ⋅ g M −1 ⋅ h −1 space time yield and considerably catalytic stability (decreased by 8 %) at 800 °C over 100 h time-on-stream. Density functional theory (DFT) calculations suggest that the adsorption capacity of Pt NP on the rutile overlayer can be reduced by increasing electron density. Experimental results combined with DFT calculations show that electron transfer from Pt NP to rutile is reduced by the oxygen vacancy defects on Pt/R, preserving the metallic nature of Pt species during CO 2 hydrogenation, thereby preventing the formation of SMSI.}, archive = {J_ANGEW}, author = {Xiaochun Hu and Dan Xu and Jianchun Jiang}, doi = {10.1002/anie.202419103}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419103}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strong metal-support interaction between pt and TiO2 over high-temperature CO2 hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Self-healing 2D anion-organic frameworks for low-temperature water release. ANGEW, 64(7), e202419096. (www)

  @article{ , abstract = {Molecular frameworks have recently shown a great potential in atmospheric water harvesting, in which the water release at low temperatures is challenging. Anion-organic frameworks based on anion-coordination chemistry are presented herein to meet this challenge. These frameworks are prepared as tubular single crystals in pure water from the in situ protonation and crystallization of pyridine-terminated triphenylamine derivatives with hydrochloric or hydrobromic acid. They possess a 2D honeycombed porous structure and carry halogen anions confined within 1D hexagonal nanochannels with a modular size of 1.7–2.3 nm. They exhibit a high water uptake of up to 0.87 g g −1 and a water release onset temperature as low as −90 °C. The water uptake and release induce significant changes in the crystal morphology and absorption and emission properties of these framework crystals, providing a visual indication of their hydration states over a wide temperature range. The kinetics of dehydration at subglacial temperatures is successfully determined by emission spectral shifts. These framework crystals show a high water-stability and can be used for repeated water capture and release thanks to a rapid and robust self-healing capability. This discovery opens opportunities for the design and synthesis of flexible and self-healing frameworks for porosity-related applications.}, archive = {J_ANGEW}, author = {Zhong-Qiu Li and Jiang-Yang Shao and Zhong-Liang Gong and Tongling Liang and Xiang Hao and Jiannian Yao and Yu-Wu Zhong}, doi = {10.1002/anie.202419096}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419096}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-healing 2D anion-organic frameworks for low-temperature water release}, volume = {64}, year = {2025}, }
• (2025). Switching residues: A platform for the synthesis of fidaxomicin antibiotics. ANGEW, 64(7), e202419095. (www)

  @article{ , abstract = {Peripheral modification is often the main approach to optimize natural products for improved biological activity or desired physicochemical properties. This procedure inevitably increases molecular weight, often accompanied by undesired increased lipophilicity. Removing structural elements from natural products is not always tolerated. This is also the case for the antibiotic fidaxomicin (Fdx), where every structural component has been shown to be crucial for antibiotic activity. In this work, we demonstrate how the residue switching approach can maintain biological activity of Fdx derivatives by replacing the rhamnoside-dichlorohomoorsellinate moiety of Fdx with smaller, more polar building blocks. We used palladium-catalysed allylic substitution to selectively install N -nucleophiles on the core of Fdx. The new derivatives were designed to mimic the binding of Fdx to the bacterial RNA polymerase. Evaluation against Mycobacterium tuberculosis , Clostridioides difficile , and the Gram-negative model organism Caulobacter crescentus demonstrated that the newly introduced residues can restore antibiotic activity, which was further supported by on-target RNA polymerase assays. We combined the allylic substitution with an organocatalysed novioside acylation protocol to enable the functionalisation of two vectors on Fdx in one pot. This platform greatly expands the accessible chemical space for Fdx derivatives and enables the future development of systemic Fdx antibiotics.}, archive = {J_ANGEW}, author = {Erik Jung and Tizian Griesser and Jordan Costafrolaz and Ondine Duverger and Yves Mattenberger and Silvia Dittmann and Andrea Dorst and Alexander Major and David Dailler and Daniel Schäfle and Susanne Sievers and Konstantin Brodolin and Patrick H. Viollier and Peter Sander and Karl Gademann}, doi = {10.1002/anie.202419095}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switching residues: A platform for the synthesis of fidaxomicin antibiotics}, volume = {64}, year = {2025}, }
• (2025). A base-free two-coordinate oxoborane. ANGEW, 64(7), e202419094. (www)

  @article{ , abstract = {Oxoboranes (R-BO) are transient species that rapidly trimerise to form boroxines. To date, the only method used to stabilise oxoboranes is to add a Lewis base, but this forms a three-coordinate at boron oxoborane that has a different bonding/reactivity profile. Herein we report a base-free, two-coordinate oxoborane that is isolated as a Lewis adduct with AlCl 3 . This species, Mes*BO-AlCl 3 (Mes*=2,4,6- t Bu-C 6 H 2 ), has a ν 11 ΒΟ stretching frequency of 1843 cm −1 , indicating a strong BO bond. Computational analysis indicates this is due to a highly polarised BO bonding interaction combined with modest BO multiple bond character. While the polarisation of the BO bond on AlCl 3 coordination enhances the Lewis acidity at boron it also reduces the basicity at oxygen and the latter is key to accessing a base-free oxoborane. Finally, this oxoborane reacts with PhN 3 in a unique way to form an unprecedented boron heterocycle.}, archive = {J_ANGEW}, author = {Clement R. P. Millet and Dominic R. Willcox and Gary S. Nichol and Cate S. Anstöter and Michael J. Ingleson}, doi = {10.1002/anie.202419094}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419094}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A base-free two-coordinate oxoborane}, volume = {64}, year = {2025}, }
• (2025). Progressive fabrication of a pt-based high-entropy-alloy catalyst toward highly efficient propane dehydrogenation. ANGEW, 64(7), e202419093. (www)

  @article{ , abstract = {High-entropy alloys (HEAs) have emerged as burgeoning heterogeneous catalysts due to their vast material space, unique structure, and superior stability. However, the dominant trial-and-error approaches hamper the exploration of efficient catalysts, necessitating the development of rational design strategies. Here, we report a progressive approach to the design and fabrication of HEA catalysts guided by alloying effects toward propane dehydrogenation. Cu, Sn, Au, and Pd are selected and demonstrated to induce dilution, encapsulation, surface enrichment, and inhomogeneity effects on Pt. The fabricated HEA, PtCuSnAuPd/SiO 2 , exhibits excellent activity, selectivity, and stability. The propylene formation rates reach 256 and 390 mol C3H6 g Pt −1 h −1 at 550 and 600 °C, respectively. Systematic characterizations reveal that the random elemental mixing, structural stability, and high Pt exposure promote the exposure of abundant stable isolated Pt sites. This work comprehensively explores the rational design and fabrication of HEA catalysts from a unique perspective, offering opportunities for developing advanced catalysts.}, archive = {J_ANGEW}, author = {Jun Luo and Xu Li and Yongjie Ye and Tao Zhou and Wenlong Wu and Hongliang Li and Qing Yang and Han Yan and Jie Zeng}, doi = {10.1002/anie.202419093}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419093}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Progressive fabrication of a pt-based high-entropy-alloy catalyst toward highly efficient propane dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Chemoenzymatic synthesis of the cyclopiane family of diterpenoid natural products. ANGEW, 64(7), e202419092. (www)

  @article{ , abstract = {A three-stage chemoenzymatic synthesis of the cyclopiane family and related diterpenes is reported. Deoxyconidiogenol with a 6/5/5/5-fused tetracyclic cyclopiane skeleton was first produced by an engineered E. coli host harboring the corresponding terpene cyclase PchDS. Ten cyclopiane diterpenes were synthesized by late-stage functionalization of rings A, B and D of the cyclopiane skeleton through direct redox operations, directed C−H activation, and enzymatic hydroxylation, respectively. Skeletal diversification was achieved by taking advantage of the selective 1,2-alkyl migration of a cyclopiane cation generated chemically or enzymatically. Three cyclopiane-related skeletons, including the spiro 5/5/5/5-tetracyclic skeleton of spiroviolene, the angular 5/6/5/5-fused ring system of phomopsene, and the new linear 5/6/5/5-fused tetracyclic ring system of amycolatene, were produced either by chemical skeletal transformation from the cyclopiane skeleton, or by terpene cyclases discovered by genome mining.}, archive = {J_ANGEW}, author = {Tao Wang and Jiasheng Zou and Kaibiao Wang and Yuanning Liu and Shouqi Zhang and Yao Kong and Zhengren Xu}, doi = {10.1002/anie.202419092}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemoenzymatic synthesis of the cyclopiane family of diterpenoid natural products}, volume = {64}, year = {2025}, }
• (2025). Molecular trapdoor in HEU zeolite enables inverse CO2-C2H2 separation. ANGEW, 64(7), e202419091. (www)

  @article{ , abstract = {The adsorptive separation of molecules with very similar physical properties is always a challenging task. Reported herein is the design and tailoring of zeolite adsorbent for the precise discrimination and separation of CO 2 -C 2 H 2 mixture through the pronounced trapdoor effect. Typically, Sr exchanged K-type clinoptilolite, namely Sr/K-HEU, is developed as a robust zeolite adsorbent for inverse CO 2 -C 2 H 2 separation, showing the-state-of-the-art dynamic CO 2 /C 2 H 2 selectivity of 48.0 and sustainable CO 2 dynamic uptake of 0.96 mmol/g at the same time. The perfect recyclability and the intrinsic low-cost nature of Sr/K-HEU make it a promising candidate for practical applications. Three-dimensional electron diffraction determines the precise structure of Sr/K-HEU and density functional theory calculations reveal the intricate interplay between guest molecules and the gate-keeping extraframework cations. Briefly, extraframework Sr 2+ cations from the ten-membered rings of HEU zeolites act as the molecular trapdoor, allowing the entry of CO 2 molecules while excluding C 2 H 2 . This work presents a new example of molecular trapdoor in zeolite and its successful application in the challenging inverse CO 2 -C 2 H 2 separation, which not only expands the scope of molecular trapdoor concept but also improves current understanding on the nature of molecular trapdoor.}, archive = {J_ANGEW}, author = {Jizhen Jia and Nana Yan and Xin Lian and Shanshan Liu and Bin Yue and Yuchao Chai and Guangjun Wu and Jian Xu and Landong Li}, doi = {10.1002/anie.202419091}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419091}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular trapdoor in HEU zeolite enables inverse CO2-C2H2 separation}, volume = {64}, year = {2025}, }
• (2025). Oriented growth of highly emissive manganese halide microrods for dual-mode low-loss optical waveguides. ANGEW, 64(7), e202419085. (www)

  @article{ , abstract = {Zero-dimensional (0D) structured lead-free metal halides have recently attracted widespread attention due to their high photoluminescence quantum yield (PLQY) and negligible self-absorption, showing enormous potential as optical waveguides towards miniaturized photonic devices. However, due to the great difficulty in growth of rod-like nano/micro-sized morphologies, such applications have been less explored. Herein, a new-type emissive organic–inorganic manganese (II) halide crystal (TPS 2 MnCl 4 , TPS=C 18 H 15 S, triphenylsulfonium) in the form of microrods is synthesized via a facile chloride ion (Cl − ) induced oriented growth method. Due to a combination of attractive features such as a high PLQY of 86 %, negligible self-absorption and smooth crystal surface, TPS 2 MnCl 4 microrods are well suited for use in optical waveguide with an ultra-low optical loss coefficient of 1.20 ⋅ 10 −4 dB μm −1 , superior to that of most organic–inorganic metal halide hybrids, organic materials, polymers and metal nanoclusters to the best of our knowledge. Importantly, TPS 2 MnCl 4 microrods can further work as dual-mode optical waveguides, combining active and passive light transmission functionalities in one single crystal. In addition, TPS 2 MnCl 4 microrods also display remarkable performance in lighting and anti-counterfeiting due to their distinct optical properties and commendable stability.}, archive = {J_ANGEW}, author = {Jin-Feng Liao and Zhipeng Zhang and Gang Wang and Lei Zhou and Ningbo Yi and Zikang Tang and Guichuan Xing}, doi = {10.1002/anie.202419085}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419085}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oriented growth of highly emissive manganese halide microrods for dual-mode low-loss optical waveguides}, volume = {64}, year = {2025}, }
• (2025). O−O radical coupling in ultrathin reconstructed Co6.8Se8 nanosheets for effective oxygen evolution and zinc-air batteries. ANGEW, 64(7), e202419083. (www)

  @article{ , abstract = {Designing ultrathin transition metal electrocatalysts with optimal surface chemistry state is crucial for oxygen evolution reaction (OER). However, the structure-dependent electrochemical performance and the underlying catalytic mechanisms are still not clearly distinguished. Herein, we synthesize ultrathin Co 6.8 Se 8 nanosheets (NSs) with subnanometer thickness by incorporating catalytically inactive selenium (Se) into ultrathin Co(OH) 2 , thereby switching the OER reaction pathway from adsorbate evolution mechanism (AEM) to oxide path mechanism (OPM). The prepared ultrathin Co 6.8 Se 8 NSs exhibit an overpotential of 253 mV at 10 mA/cm 2 , outperforming the mostly reported Co-based electrocatalysts. Advanced operando synchrotron spectroscopies and X-ray absorption spectroscopy reveal the ultrathin Co 6.8 Se 8 NSs, whose surface is reconstructed into Se-doped Co(OH) 2 during the OER process, could trigger direct O*−O* radical coupling rather than OOH* intermediates within AEM pathway thus lowering the energy input. Density functional theory calculations confirm that Co 6.8 Se 8 NSs with shorter Co−Co bond length and stable Co−Se bond could optimize the rate-determining step barrier via OPM pathway. Besides, rechargeable zinc-air batteries based on Co 6.8 Se 8 NSs exhibit excellent stability for more than 500 h of continuous charge–discharge cycles at 4 mA/cm 2 . The present study highlights the structural-dependent switch of OER pathways and provides valuable insights for further development of ultrathin OER catalysts.}, archive = {J_ANGEW}, author = {Chuansheng He and Linlin Yang and Chengyuan Dong and Xiaohui Peng and Yousef Ibraheem and Oleg Usoltsev and Laura Simonelli and Ren He and Andreu Cabot and Yizhong Lu}, doi = {10.1002/anie.202419083}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419083}, shortjournal = {Angew. Chem. Int. Edit.}, title = {O−O radical coupling in ultrathin reconstructed Co6.8Se8 nanosheets for effective oxygen evolution and zinc-air batteries}, volume = {64}, year = {2025}, }
• (2025). Iron oxide clusters as electron donors under light enhance oxygen reduction kinetics at atomically dispersed fe for photocatalytic CH4 partial oxidation. ANGEW, 64(7), e202419075. (www)

  @article{ , abstract = {Photocatalytic CH 4 oxidation to CH 3 OH emerges as a promising strategy to sustainably utilize natural gas and mitigate the greenhouse effect. However, there remains a significant challenge for the synthesis of methanol by using O 2 at low temperature. Inspired by the catalytic structure in soluble methane monooxygenase (MMO) and the corresponding reaction mechanism, we prepared a biomimetic photocatalyst with the decoration of Fe 2 O 3 nanoclusters and satellite Fe single atoms immobilized on carbon nitride. The catalyst demonstrates an excellent CH 3 OH productivity of 5.02 mmol ⋅ g cat −1 ⋅ h −1 with CH 3 OH selectivity of 98.5 %. Mechanism studies reveal that the synergy between Fe 2 O 3 nanoclusters and Fe single atoms establishes a dual-Fe site as MMO for O 2 activation and subsequent CH 4 partial oxidation. Moreover, the light excitation of Fe 2 O 3 nanoclusters with a relative narrow band gap could deliver the electrons and protons to atomic Fe that facilitating the oxygen reduction kinetics for the robust of CH 3 OH synthesis.}, archive = {J_ANGEW}, author = {Yueyuan Xu and Xianfeng Shen and Shuai Guo and Yao Lv and Ke Wang and Yao Shi and Yukun Li and Mi Yan and Peng Zhang and Sheng Dai and Kuan Lu and Pengfei Xie}, doi = {10.1002/anie.202419075}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419075}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron oxide clusters as electron donors under light enhance oxygen reduction kinetics at atomically dispersed fe for photocatalytic CH4 partial oxidation}, volume = {64}, year = {2025}, }
• (2025). High-efficiency perovskite solar cells enabled by guanylation reaction for removing MACl residual and in-situ forming 2D perovskite. ANGEW, 64(7), e202419070. (www)

  @article{ , abstract = {The thermodynamical deprotonation of methylammonium chloride (MACl) has several detrimental influences on the quality of formamidinium (FA + )-based perovskite, which limits both efficiency and stability of inverted perovskite solar cells (IPSCs). Herein, a new additive strategy was developed by introducing methyl carbamimidothioate hydroiodide (MCH) into perovskite precursor, where guanylation reaction occurred between MCH and MACl to form a new intermediate of methyl-substituted guanidine (MSG). MSG could then bond with undercoordinated Pb 2+ to in situ form a two-dimensional (2D) perovskite, which would promote the growth and crystallization of three-dimensional (3D) perovskite with higher crystallinity, lower defect-states density and superior stability. Finally, the MCH-treated IPSC with a small area (0.09 cm 2 ) achieved an impressive power conversation efficiency (PCE) of 26.81 % (certified as 26.02 %), which is one of the highest PCEs reported to date. The large area MCH-treated device (1.00 cm 2 ) also obtained a high PCE of 24.36 %. Moreover, the unencapsulated and MCH-treated device exhibited excellent operational stability, maintaining 91.95 % and 97.06 % of their initial efficiencies after aging in air and a nitrogen-filled atmosphere at 85 °C for 1200 h. The encapsulated MCH-treated devices retained 94.25 % of its initial efficiency after continuously tracking at the maximum power-point for 1200 h in air.}, archive = {J_ANGEW}, author = {Zhuang Xie and Yuwei Duan and Minghui Cheng and Yong Li and Zhike Liu and Hongxiang Li and Yu Chen and Zhigang Zang and Shengzhong Liu and Qiang Peng}, doi = {10.1002/anie.202419070}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-efficiency perovskite solar cells enabled by guanylation reaction for removing MACl residual and in-situ forming 2D perovskite}, volume = {64}, year = {2025}, }
• (2025). Heterochiral self-discrimination driven dimerization of polynuclear Gold(I)-sulfido complexes with enhanced phosphorescence. ANGEW, 64(7), e202419062. (www)

  @article{ , abstract = {Decanuclear chiral gold(I) sulfido clusters ( S SDP -Au 10 and R SDP -Au 10 ) have been assembled by taking advantage of the judiciously selected SDP ligands (SDP = 7,7′-bis(diphenylphosphino)-1,1′-spirobiindane). Interestingly, an achiral heterodimer icosanuclear meso -cluster ( meso SDP -Au 20 ) has been obtained by simply mixing S SDP -Au 10 and R SDP -Au 10 in a 1:1 ratio. These gold(I) complexes have been found to display intense near-infrared (NIR) luminescence with an emission maximum at around 750 nm in the solid state. The photoluminescence quantum yield (PLQY) of meso SDP -Au 20 in drop-cast solid-state thin film has been found to show a significant enhancement from 8 % in the S SDP -Au 10 and R SDP -Au 10 to 25 %. In addition, the dimerization process with heterochiral self-discrimination has been found to be sensitive to the solvent polarity and configuration of the diphosphine ligand. This work has provided a platform for the investigation and mechanistic understanding of heterochiral self-sorting and assembly processes.}, archive = {J_ANGEW}, author = {Liang-Liang Yan and Ziyong Chen and Vivian Wing-Wah Yam}, doi = {10.1002/anie.202419062}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterochiral self-discrimination driven dimerization of polynuclear Gold(I)-sulfido complexes with enhanced phosphorescence}, volume = {64}, year = {2025}, }
• (2025). Idealizing air-processed perovskite film competitive by surface lattice etching-reconstruction for high-efficiency solar cells. ANGEW, 64(7), e202419061. (www)

  @article{ , abstract = {Air-processed perovskite solar cells are desirable for the large-scale manufacturing application in the future, yet the presence of moisture and oxygen goes against perovskite crystallization and deteriorates phase stabilization, leading to the formation of substantial defective nano-impurities, especially on the vulnerable surface. Here, we propose a strategy to simultaneously remove superficial defect layer and solidify the surface by soaking air-fabricated perovskite film into low-polar organic esters at elevated temperature to trigger an in situ dynamic surface lattice disassemble and reconstruction process. Molecular dynamics simulations and experimental results indicate that the inorganic CsPbI 2 Br perovskite is first dissolved and then the Br-rich phase is recrystallized at solid–liquid interface owing to the balance between weak solubility and high-temperature induced annealing process, thus hardening the soft surface and releasing the lattice tensile stress, which benefits the minimization of interfacial recombination and improvement of the structural stability. As a result, we prepare a carbon-based CsPbI 2 Br device in complete air without precise control on humidity, achieving a champion efficiency of 15.37 % with excellent resistance to harsh attackers. This method offers a promising avenue for overcoming the limit of processing conditions on advancing perovskite-based optoelectronic devices.}, archive = {J_ANGEW}, author = {Hui Li and Jialong Duan and Chenlong Zhang and Naimin Liu and Linzheng Ma and Xingxing Duan and Jie Dou and Qiyao Guo and Benlin He and Yuanyuan Zhao and Qunwei Tang}, doi = {10.1002/anie.202419061}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419061}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Idealizing air-processed perovskite film competitive by surface lattice etching-reconstruction for high-efficiency solar cells}, volume = {64}, year = {2025}, }
• (2025). A chlorine-resistant self-doped nanocarbon catalyst for boosting hydrogen peroxide synthesis in seawater. ANGEW, 64(7), e202419049. (www)

  @article{ , abstract = {Developing seawater-compatible hydrogen peroxide (H 2 O 2 ) electroproduction technologies is crucial for advancing marine resource utilization in coastal regions. However, designing efficient and highly stable non-noble metal catalysts for two-electron oxygen reduction reaction (2e − ORR) in seawater environment remains a challenging task due to the corrosive and toxic nature of chloride ions (Cl − ). Herein, we present, for the first time, a novel nitrogen and oxygen self-doped defect-rich nanocarbon (NO-DC 700 ) catalyst, derived from silk fiber, which addresses these challenges with low toxicity, cost-effectiveness, and high adaptability. The obtained NO-DC 700 catalyst demonstrates an impressive H 2 O 2 production rate of up to 4997 mg L −1 h −1 , a high Faradaic efficiency of 96.5 %, and produces 4.3 wt % H 2 O 2 after 20 hours of stable operation, placing it among the highest-performing catalysts reported in neutral electrolytes. Theoretical calculations reveal that NO-DC 700 ′s superior 2e − ORR performance is due to the synergistic effect of graphitic nitrogen and C-OH, which inhibits Cl − adsorption and promotes *OOH adsorption. Additionally, integrating 2e − ORR with Fenton-like technology enables rapid degradation of organic pollutants and effective inactivation of seawater algae, offering significant potential for mitigating coastal eutrophication and red tide pollution. This work provides valuable insights into H 2 O 2 electrosynthesis in seawater solution and promises advancements in ocean-energy applications.}, archive = {J_ANGEW}, author = {Xinyu Wang and Wangqiang Shen and Chang Zhang and Yuzhong Huang and Jian Zhang and Jun Lv and Xing Lu}, doi = {10.1002/anie.202419049}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419049}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A chlorine-resistant self-doped nanocarbon catalyst for boosting hydrogen peroxide synthesis in seawater}, volume = {64}, year = {2025}, }
• (2025). Optimizing Propylene/Propane sieving separation through gate-pressure control within a flexible organic framework. ANGEW, 64(7), e202419047. (www)

  @article{ , abstract = {The separation of propylene (C 3 H 6 ) and propane (C 3 H 8 ) is of great significance in the chemical industry, which poses a challenge due to their almost identical kinetic diameters and similar physical properties. In this work, we synthesized an ultramicroporous flexible hydrogen-bonded organic framework (named HOF-FJU-106) by using molecule 2,3,6,7-tetra (4-cyanophenyl) tetrathiafulvalene (TTF-4CN). The formation of the dimer causes the TTF-4CN molecular to bend and weaken π-stacked interactions, coupled with the flexibility of C≡N H−C hydrogen bonds, which leads to reversible conversion between open and closed frameworks through the mutual slip of adjacent layers/columns under activation and stimulation of gas molecules. Through gas adsorption isotherms and adsorption enthalpy, HOF-FJU-106a exhibited adaptive adsorption and stronger binding affinity for C 3 H 6, and presented a recorded gas uptake ratio of C 3 H 6 /C 3 H 8 (23.77) among presentative HOF materials at room temperature to date. Importantly, the flexible HOF-FJU-106a shows an interesting phenomenon about the reversible gate pressure control under variable temperature, which realized the gas adsorption and separation performance enhancement for the binary C 3 H 6 /C 3 H 8 mixtures. This strategy through designing HOFs with thermoregulatory gating effect is a powerful way to maximize the performance of materials.}, archive = {J_ANGEW}, author = {Lu Li and Fahui Xiang and Yunbin Li and Yisi Yang and Zhen Yuan and Yanting Chen and Furong Yuan and Lei He and Shengchang Xiang and Banglin Chen and Zhangjing Zhang}, doi = {10.1002/anie.202419047}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419047}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optimizing Propylene/Propane sieving separation through gate-pressure control within a flexible organic framework}, volume = {64}, year = {2025}, }
• (2025). Liquid crystalline nanorods by synchronized polymerization, self-assembly and oriented attachment for utilization in magnetically responsive displays. ANGEW, 64(7), e202419042. (www)

  @article{ , abstract = {The creation of anisotropic nanoparticles (NPs) by polymerization and/or self-assembly (SA) has significantly promoted the applications of polymer nanomaterials in many fields. However, polymer nanorods are not easily accessible via conventional polymerization or SA. Here we report a one-step route to synthesize single-domain smectic liquid crystalline (LC) nanorods utilizing oriented attachment (OA) that was usually found in the synthesis of inorganic NPs, synchronized with polymerization and SA. The synchronization was achieved by developing a novel stabilizer derived from a thermo-responsive polyelectrolyte system. Mechanistic studies reveal that controlling the thermo-responsive behavior and the distribution of stabilizers on NPs enabled OA. The LC nanorods can further form hierarchical colloidal LCs, which show much larger light transmittance than that of non-LC nanorods. Moreover, we demonstrate that this LC system can be manipulated by an external magnetic field, thus providing a candidate material for magnetic-responsive display.}, archive = {J_ANGEW}, author = {Xiao Wang and Jiawei Lu and An-Chang Shi and Bing Liu}, doi = {10.1002/anie.202419042}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419042}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Liquid crystalline nanorods by synchronized polymerization, self-assembly and oriented attachment for utilization in magnetically responsive displays}, volume = {64}, year = {2025}, }
• (2025). A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity. ANGEW, 64(7), e202419031. (www)

  @article{ , abstract = {Opioid use disorder - particularly involving fentanyl - has precipitated a public health crisis characterized by a significant increase in addiction and overdose-related deaths. Fentanyl-specific immunotherapy, which aims at inducing fentanyl-specific antibodies capable of binding fentanyl molecules in the bloodstream, preventing their entry in the central nervous system, is therefore gaining momentum. Conventional opioid designs rely on the covalent conjugation of fentanyl analogues to immunogenic carrier proteins that hold the inherent capacity of mounting immunodominant responses. Here, we present an alternative fentanyl vaccine design that utilizes a non-covalent assembly of lipid nanoparticles (LNPs) to deliver fentanyl haptens in conjunction with a CD4 + T-helper peptide epitope and an imidazoquinoline TLR7/8 agonist. Our results demonstrate that a single intramuscular administration of the LNP-based nanovaccine elicits fentanyl-specific antibodies, significantly mitigating the effects of opioid overdose in preclinical mouse models. Furthermore, we analyzed the immunobiological behavior of the vaccine in vivo in mouse models, providing evidence that covalent attachment of a fentanyl hapten to a carrier proteins or peptide epitope is not necessary for inducing an effective immune response. However, co-delivery - specifically, the physical assembly of all immune cues into an LNP - remains essential for inducing hapten-specific immunity.}, archive = {J_ANGEW}, author = {Zifu Zhong and Marie H. Deventer and Yong Chen and Stijn Vanhee and Inés Lammens and Kim Deswarte and Yi Huang and Tingting Ye and Haixiu Wang and Lutz Nuhn and Marthe M. Vandeputte and Mark Gontsarik and Xiaole Cui and Niek N. Sanders and Stefan Lienenklaus and Bart N. Lambrecht and Antonio P. Baptista and Christophe P. Stove and Bruno G. De Geest}, doi = {10.1002/anie.202419031}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity}, volume = {64}, year = {2025}, }
• (2025). Versatile strategy for the chemoenzymatic synthesis of branched human milk oligosaccharides containing the lacto-N-biose motif. ANGEW, 64(7), e202419021. (www)

  @article{ , abstract = {Human milk oligosaccharides (HMOs) exhibit prebiotic, antimicrobial, and immunomodulatory properties and confer significant benefits to infants. Branched HMOs are constructed through diverse glycosidic linkages and prominently feature the lacto- N -biose (LNB, Gal-β1,3-GlcNAc) motif with fucose and/or sialic acid modifications, displaying structural complexity that surpasses that of N - and O -glycans. However, synthesizing comprehensive libraries of branched HMO is challenging due to this complexity. Although a few systematic synthetic strategies have emerged, many of them rely on labor-intensive chemical methodologies or exploit the substrate specificity of human N -acetylglucosaminyltransferase 2 (hGCNT2). In this study, we capitalized on the substrate promiscuities of hGCNT2 and bacterial glycosyltransferases (GTs) to construct a universal tetrasaccharide core in a highly efficient manner. This core was systematically and flexibly extended to generate diverse branched HMOs utilizing the promiscuity of bacterial GTs coupled with N -trifluoroacetyl glucosamine (GlcNTFA), which facilitated sugar chain elongation. The GlcNTFA residues were subsequently converted into various N -modified glucosamines through straightforward chemical manipulations to modulate the activities of additional GTs during glycan extension. These masked amino groups were ultimately reverted to N -acetyl groups, facilitating the synthesis of a broad range of asymmetric and multiantennary HMOs featuring LNB moieties, including many previously inaccessible structures.}, archive = {J_ANGEW}, author = {Hsin-Kai Tseng and Ting-Yi Lee and Yu-Ching Chiang and Wen-Hua Kuo and Hsien-Wei Tseng and Hung-Kai Wang and Chi-Kung Ni and Chun-Cheng Lin}, doi = {10.1002/anie.202419021}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202419021}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Versatile strategy for the chemoenzymatic synthesis of branched human milk oligosaccharides containing the lacto-N-biose motif}, volume = {64}, year = {2025}, }
• (2025). Self-assembled monolayer in hybrid quasi-solid electrolyte enables boosted interface stability and ion conduction. ANGEW, 64(7), e202418999. (www)

  @article{ , abstract = {Complex interactions between the inorganic solid electrolyte (ISE) and the liquid electrolyte (LE) give rise to challenges of achieving durable interface stability in hybrid quasi-solid electrolytes (HQSE), and the influence on the involved ISE surface ionic conductivity also needs to be investigated. Here, 4-chlorobenzenesulfonic acid (CBSA) is utilized to establish a self-assembled monolayer (SAM) on the surface of Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 (LLZTO), which is then incorporated into PEGDA-based in situ polymerized HQSE. The results show that the introduction of CBSA significantly improves the LLZTO/LE interface stability with the optimized solvation structure, resulting in a favorable ionic conductivity (1.19 mS⋅cm −1 ) and an increasing Li + transference number (0.647). Mechanisms for the promotion of ionic conduction and interfacial stability of SAM-HQSE are unveiled through the density functional theory (DFT) combined with Raman spectra and 7 Li solid-state nuclear-magnetic-resonance. There are no short-circuits in the Li|SAM-HQSE|Li cells after 1000 h. The LFP|SAM-HQSE|Li cells or LFP|SAM-HQSE|Graphite pouch cells respectively achieve the capacity retention of 91.2 % and 87.0 % with the 0.5.C-rate for 500 and 300 cycles. This facile and effective strategy proposed in this work make it accessible for constructing the stable surface micro-environments of LLZTO where boost and homogenize the Li + conduction in a hybrid quasi-solid electrolyte system.}, archive = {J_ANGEW}, author = {Wenyi Ma and Yuxiang Guo and Jianqi Sun and Chenyi Zhang and Yuwen Zhu and Hengda Sun and Liqiang Huang and Zuming Hu and Hongzhi Wang and Meifang Zhu and Gang Wang}, doi = {10.1002/anie.202418999}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418999}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled monolayer in hybrid quasi-solid electrolyte enables boosted interface stability and ion conduction}, volume = {64}, year = {2025}, }
• (2025). Enhanced chirality transfer in self-assembled nanocomposites powered by a trace amount of chiral dimeric molecules. ANGEW, 64(7), e202418997. (www)

  @article{ , abstract = {Chiral-selective self-assembly has markedly advanced the development of chiral materials. While the Sergeant and Soldiers principle allows for chirality amplification, it necessitates precise shape-matching between chiral and achiral molecules, leading to a low chirality transfer efficiency-where one chiral molecule influences the chirality of a limited number of achiral molecules. Here, we show that this efficiency can be markedly enhanced by introducing chiral dimeric molecules. In this work, a single chiral molecule can control the chirality of up to 200 achiral molecules and even direct the assembly of inorganic nanoparticles into chiral nanocomposites through a sequential chirality transfer process. Moreover, this approach exhibits remarkable robustness, operating effectively without necessitating a precise match between chiral and achiral molecules. Consequently, using the same chiral molecules at an exceptionally low molar fraction (0.5 mol %) allows for the chiral-selective assembly of achiral molecules over a broad spectrum, regardless of their packing habits, thus facilitating the creation of otherwise inaccessible chiral materials with modulated chiroptical properties. Last but not least, even a trace amount of chiral molecules can enhance the elastic modulus of the self-assembled nanocomposites by a factor of eight.}, archive = {J_ANGEW}, author = {Yuting Bi and Zongze Zhang and Jingjing Wei and Zhijie Yang}, doi = {10.1002/anie.202418997}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418997}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced chirality transfer in self-assembled nanocomposites powered by a trace amount of chiral dimeric molecules}, volume = {64}, year = {2025}, }
• (2025). Molecular chain rearrangement of natural cellulose-based artificial interphase for ultra-stable zn metal anodes. ANGEW, 64(7), e202418992. (www)

  @article{ , abstract = {The unstable electrolyte-anode interface, plagued by parasitic side reactions and uncontrollable dendrite growth, severely hampers the practical implementation of aqueous zinc-ion batteries. To address these challenges, we developed a regenerated cellulose-based artificial interphase with synergistically optimized structure and surface chemistry on the Zn anode (RC@Zn), using a facile molecular chain rearrangement strategy. This RC interphase features a drastically increased amorphous region and more exposed active hydroxyl groups, facilitating rapid Zn 2+ diffusion and homogeneous Zn 2+ interface distribution, thereby enabling dendrite-free Zn deposition. Additionally, the compact texture and abundant negatively charged surface of the RC interphase effectively shield water molecules and harmful anions, completely preventing H 2 evolution and Zn corrosion. The superior mechanical strength and adhesion of the RC interphase also accommodate the substantial volume changes of Zn anodes even under deep cycling conditions. Consequently, the RC@Zn electrode demonstrates an outstanding cycling lifespan of over 8000 hours at a high current density of 10 mA cm −2 . Significantly, the electrode maintains stable cycling even at a 90 % depth of discharge and ensures stable operation of full cells with a low negative/positive capacity ratio of 1.6. This study provides new solution to construct highly stable and deep cycling Zn metal anodes through interface engineering.}, archive = {J_ANGEW}, author = {Jizhen Wang and Long Jiao and Chao Yi and Hongyuan Bai and Qiaoyun Liu and Yusen Fu and Jiajia Liu and Chuang Wang and Yechen Lei and Tian Zhang and Jiaqi Wen and Leixin Yang and Dengkun Shu and Shuo Yang and Chenyang Li and Huan Li and Wenjun Zhang and Bowen Cheng}, doi = {10.1002/anie.202418992}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418992}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular chain rearrangement of natural cellulose-based artificial interphase for ultra-stable zn metal anodes}, volume = {64}, year = {2025}, }
• (2025). Methanolation of olefins: Low-pressure synthesis of alcohols by the formal addition of methanol to olefins. ANGEW, 64(7), e202418984. (www)

  @article{ , abstract = {Methanolation of olefins is introduced as a new low-pressure synthetic pathway to C1 elongated alcohols. Formally, H 3 COH is added to the C=C bond in a 100 % atom efficient manner. Mechanistically, the overall transformation occurs as a tandem reaction sequence by combining the dehydrogenation of methanol to syngas at a CO : H 2 ratio of 1 : 2 with subsequent hydroformylation to the corresponding aldehyde and its final hydrogenation to the alcohol. The dehydrogenation and hydrogenation steps are catalyzed by a Mn/pincer complex, while the hydroformylation is accomplished by a Rh/phosphine catalyst. Using 1-octene as prototypical substrate, a yield of 80 % nonanol was achieved with a ratio of 93 : 7 of linear to branched alcohols and turnover numbers (TON Rh ) of more than 17 000 could be obtained in relation to the precious metal Rhodium. The integrated catalytic system provides direct access to alcohols from olefins and “green” methanol, avoiding the handling of pressurized CO and H 2 and the use of specialized high-pressure equipment as the process conditions do not exceed 10 bar with partial pressures of syngas in the range of only 1–2 bar.}, archive = {J_ANGEW}, author = {Sebastian Stahl and Jeroen T. Vossen and Stephan Popp and Walter Leitner and Andreas J. Vorholt}, doi = {10.1002/anie.202418984}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418984}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Methanolation of olefins: Low-pressure synthesis of alcohols by the formal addition of methanol to olefins}, volume = {64}, year = {2025}, }
• (2025). Single-atom pt loaded on MOF-derived porous TiO2 with maxim-ized pt atom utilization for selective hydrogenation of halonitro-benzene. ANGEW, 64(7), e202418964. (www)

  @article{ , abstract = {The location control of single atoms relative to supports is challenging for single-atom catalysts, leading to a large proportion of inaccessible single atoms buried under supports. Herein, a “sequential thermal transition” strategy is developed to afford single-atom Pt preferentially dispersed on the outer surface of TiO 2 . Specifically, a Ti-MOF confining Pt nanoparticles is converted to Pt NPs and TiO 2 composite coated by carbon (Pt NPs &TiO 2 @C-800) at 800 °C in N 2 . Subsequent thermal-driven atomization of Pt NPs at 600 °C in air produce single-atom Pt decorated TiO 2 (Pt 1 /TiO 2 -600). The resulting Pt 1 /TiO 2 -600 exhibits superior p -chloroaniline ( p -CAN) selectivity (99 %) to Pt NPs /TiO 2 -400 (45 %) and much better activity than Pt 1 @TiO 2 -600 with randomly dispersed Pt 1 both outside and inside TiO 2 in the hydrogenation of p -chloronitrobenzene ( p -CNB). Mechanism investigations reveal that Pt 1 /TiO 2 -600 achieves 100 % accessibility of Pt 1 and preferably adsorbs the –NO 2 group of p -CNB while weakly adsorbs –Cl group of p -CNB and p -CAN, promoting catalytic activity and selectivity.}, archive = {J_ANGEW}, author = {Mingchun Guo and Qiangqiang Meng and Ming-Liang Gao and Lirong Zheng and Qunxiang Li and Long Jiao and Hai-Long Jiang}, doi = {10.1002/anie.202418964}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418964}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-atom pt loaded on MOF-derived porous TiO2 with maxim-ized pt atom utilization for selective hydrogenation of halonitro-benzene}, volume = {64}, year = {2025}, }
• (2025). Rapid na+ transport pathway and stable interface design enabling ultralong life solid-state sodium metal batteries. ANGEW, 64(7), e202418959. (www)

  @article{ , abstract = {Sodium-metal batteries (SMBs) using solid-state polymer electrolytes (SPEs) show impressive superiority in energy density and safety. As promising candidates for SPEs, solid-state plastic crystal electrolytes (SPCE) based on succinonitrile (SN) plastic crystal could achieve high ion conductivity and wide voltage window. Nonetheless, the notorious SN decomposition reaction on the electrode/electrolyte interface seriously challenges the stable operation of the battery. To address this drawback, we commence with the structural engineering of the polymer chain segments in SPCE and employ intermolecular interactions to optimize the composition of solid electrolyte interface (SEI). Moreover, this study emphasizes the importance of polymer network design in optimizing the migration behavior of sodium ions in SPCE. The assembled sodium symmetric cells display a high critical current density of up to 2.7 mA cm −2 and stable cycling performance for 700 hours at 0.5 mA cm −2 . Furthermore, the Na/SPCE-9/Na 3 V 2 (PO 4 ) 3 maintains a discharge specific capacity of up to 76.8 mAh g −1 at 10 C and shows impressive long-cycle stability, retaining 86.2 % of initial capacity over 5000 cycles with an average coulombic efficiency of 99.9 %. Our work presents a high-performance SPCE with intrinsic safety, providing valuable insights for the future design of solid-state SMBs.}, archive = {J_ANGEW}, author = {Chang Su and Yunpeng Qu and Naiwen Hu and Lin Wang and Zihui Song and Mengfan Pei and Runyue Mao and Xin Jin and Dongming Liu and Xigao Jian and Fangyuan Hu}, doi = {10.1002/anie.202418959}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418959}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid na+ transport pathway and stable interface design enabling ultralong life solid-state sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). An expeditious synthesis of near-infrared-absorbing imide-based graphene nanoribbons and their photothermal properties. ANGEW, 64(7), e202418955. (www)

  @article{ , abstract = {Graphene nanoribbons (GNRs) with low band gap and strong near-infrared (NIR) absorption are potential candidates for optoelectronic and biomedical applications. In this context, imide-based GNRs are promising, but there are no rational design principles that yield these robust GNRs with strong NIR absorption. Here, we demonstrate a rational synthesis route to achieve NIR-absorbing imide-based robust GNRs by exploring the bay region of polyperylene (PP). Using the oxidative Diels–Alder reaction, we have successfully introduced mono and diimide functional groups on PP. After cyclodehydrogenation, the resultant GNRs, benzoperylene imide GNR ( BPI-GNR ) and coronene diimide GNR ( CDI-GNR ), show oscillatory edge geometry with strong NIR absorption (up to 1000 nm) and optical band gap of ~1.3 eV. Computational studies also indicate that imide substituents play an important role in fine-tuning the optoelectronic properties of GNRs. Moreover, these GNRs are solution-processable and can be made into thin films via spray coating. Owing to the strong NIR absorption and imide substitutions, BPI and CDI-GNRs show good photothermal conversion with excellent cyclic stability.}, archive = {J_ANGEW}, author = {Akash Shamrao Nandgaye and Kalpak Ghosh and Sharma S. R. K. C. Yamijala and Kotagiri Venkata Rao}, doi = {10.1002/anie.202418955}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418955}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An expeditious synthesis of near-infrared-absorbing imide-based graphene nanoribbons and their photothermal properties}, volume = {64}, year = {2025}, }
• (2025). Stereospecific 3-aza-cope rearrangement interrupted asymmetric allylic substitution-isomerization. ANGEW, 64(7), e202418951. (www)

  @article{ , abstract = {Transition-metal catalyzed asymmetric allylic substitution with alkyl and heteroaryl carbon nucleophiles has been well-established. However, the asymmetric allylic arylation of acyclic internal alkenes with aryl nucleophiles remains challenging and underdeveloped. Herein we report a stereospecific 3-aza-Cope rearrangement interrupted asymmetric allylic substitution-isomerization ( Int-AASI ) that enables asymmetric allylic arylation. By means of this stepwise strategy, both enantioenriched allylic arylation products and axially chiral alkenes could be readily obtained in high enantioselectivities. Experimental studies support a mechanism involving a cascade of asymmetric allylic amination, stereospecific 3-aza-Cope rearrangement and alkene isomerization. Density functional theory studies detailed the reasons of achieving the high chemoselectivity, regioselectivity, stereoselectivity and stereospecificity, respectively.}, archive = {J_ANGEW}, author = {Hong-Feng Zhuang and Jun Gu and Zhiwen Ye and Ying He}, doi = {10.1002/anie.202418951}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418951}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereospecific 3-aza-cope rearrangement interrupted asymmetric allylic substitution-isomerization}, volume = {64}, year = {2025}, }
• (2025). Optically modulated nanofluidic ionic transistor for neuromorphic functions. ANGEW, 64(7), e202418949. (www)

  @article{ , abstract = {Neuromorphic systems that can emulate the behavior of neurons have garnered increasing interest across interdisciplinary fields due to their potential applications in neuromorphic computing, artificial intelligence and brain-machine interfaces. However, the optical modulation of nanofluidic ion transport for neuromorphic functions has been scarcely reported. Herein, inspired by biological systems that rely on ions as signal carriers for information perception and processing, we present a nanofluidic transistor based on a metal–organic framework membrane (MOFM) with optically modulated ion transport properties, which can mimic the functions of biological synapses. Through the dynamic modulation of synaptic weight, we successfully replicate intricate learning-experience behaviors and Pavlovian associate learning processes by employing sequential optical stimuli. Additionally, we demonstrate the application of the International Morse Code with the nanofluidic device using patterned optical pulse signals, showing its encoding and decoding capabilities in information processing process. This study would largely advance the development of nanofluidic neuromorphic devices for biomimetic iontronics integrated with sensing, memory and computing functions.}, archive = {J_ANGEW}, author = {Jiao Wang and Yanan Jiang and Tianyi Xiong and Jiahao Lu and Xiulan He and Ping Yu and Lanqun Mao}, doi = {10.1002/anie.202418949}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optically modulated nanofluidic ionic transistor for neuromorphic functions}, volume = {64}, year = {2025}, }
• (2025). Enhanced antitumor immunity of a globo H-based vaccine enabled by the combination adjuvants of 3D-MPL and QS-21. ANGEW, 64(7), e202418948. (www)

  @article{ , abstract = {Globo H, a specific carbohydrate antigen overexpressed on various human malignancies, has attracted considerable interest as an antigenic target for anticancer vaccine development. Despite several Globo H-based carbohydrate vaccines that have been designed, efficient access to Globo H hexasaccharide antigen and development of powerful adjuvants for enhancing antitumor immunity remain challenging. Herein, we reported a streamlined chemoenzymatic approach to prepare this hexasaccharide antigen, relying on chemical synthesis of Gb5 pentasaccharide by a stereoconvergent [2+3] strategy and subsequent enzymatic α-fucosylation to easily install α1,2-fucose residue. Separately, a modular assembly approach to efficiently synthesize 3- O -deacyl-monophosphoryl lipid A (3D-MPL) was developed by the integration of stereocontrolled glycosylation, regioselective acylation, site-specific phosphorylation, and facile global deprotection. After efficient construction of Globo H-CRM197 conjugate, we conducted systematic immunological evaluations of Globo H-CRM197 formulated with various adjuvants and adjuvant combinations, comprising saponin QS-21, synthetic 3D-MPL and α-galactosylceramide derivative S34. The results revealed that Globo H-CRM197 conjugate adjuvanted with QS-21 and 3D-MPL elicited robust IgG2a and IgG3 antibody responses and Th1 cellular immunity in mice. Moreover, antibodies induced by this formulation effectively bound to Globo H-positive MCF-7 cancer cells and exhibited superior complement-dependent cytotoxicity and antibody-dependent cellular phagocytosis, holding promise for further development of effective anticancer vaccines.}, archive = {J_ANGEW}, author = {Wenjing Ma and Zhuojia Xu and Changcai Teng and Chang Cao and Ruixue Wu and Xiao Meng and Qiang Sui and Qi Gao and Chengli Zong and Tiehai Li}, doi = {10.1002/anie.202418948}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418948}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced antitumor immunity of a globo H-based vaccine enabled by the combination adjuvants of 3D-MPL and QS-21}, volume = {64}, year = {2025}, }
• (2025). Sugar auxiliary group assisted diversity-oriented enzymatic modular synthesis of 0-series ganglioside glycans. ANGEW, 64(7), e202418929. (www)

  @article{ , abstract = {Owing to the inaccessibility of β1–4- N -acetylgalactosaminyltransferase for direct glycan chain elongation, the enzymatic synthesis of 0-series gangliosides with extended backbones has not been explored. In this study, sialic acid was enzymatically introduced as an auxiliary group to overcome the limitation of substrate specificity of Campylobacter jejuni β1–4- N -acetylgalactosaminyltransferase (CjCgtA) to achieve the synthesis of desired extended 0-series ganglioside core structures, and the sialic acid auxiliary group could be removed by sialidase at appropriate stages. A bacterial α2–6-sialyltransferase from Photobacterium damselae (Pd2,6ST) exhibited unexpected acceptor substrate specificity for 0-series ganglioside core structures, providing ready access to complex gangliosides bearing the sialyl N -acetylgalactosamine unit. The 0-series ganglioside core structures as the key acceptor substrates were further diversified by sequential enzymatic modular assembly to generate a collection of 31 complex 0-series ganglioside glycans after removal of the sugar auxiliary group of sialic acid at the appropriate stage.}, archive = {J_ANGEW}, author = {Jinfeng Ye and Kan Zhong and Zhi-Fei Hu and Chang-Cheng Liu and Ming Li and Peng Wu and Hongzhi Cao}, doi = {10.1002/anie.202418929}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418929}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sugar auxiliary group assisted diversity-oriented enzymatic modular synthesis of 0-series ganglioside glycans}, volume = {64}, year = {2025}, }
• (2025). Towards highly stable sn2+ electrolyte for aqueous tin batteries using hydroquinone antioxidant. ANGEW, 64(7), e202418928. (www)

  @article{ , abstract = {Sn redox chemistry in aqueous acidic electrolyte was characterized with high reversibility and kinetics, which is considered as competitive anode material for aqueous batteries. Unfortunately, divalent Sn 2+ is unstable in aqueous electrolyte. It was revealed that Sn 2+ is easy to be oxidized to tetravalent Sn 4+ by dissolved oxygen and then forms precipitate through hydrolysis process, leading to serious performance decay. Here, hydroquinone (HQ) was employed as antioxidant to prevent Sn 2+ oxidation. With addition of HQ, Sn 2+ electrolyte can maintain transparent and colorless after long-time exposure under air atmosphere, while large amounts of sediment were observed in the electrolyte without HQ. Moreover, HQ can adsorb on electrode surface to regulate Sn deposition and suppress Sn dendrite formation. With the difunctional HQ additive, Sn anode shows a stable cycling performance more than 1500 cycles with a high average coulombic efficiency (CE) of 99.9 %. And the organic||Sn cell shows high cycling stability for 10,000 cycles with 71 % capacity retention. The hydroquinone antioxidant strategy provides a facile and cost-effective way to develop highly stable Sn 2+ -based electrolyte.}, archive = {J_ANGEW}, author = {Qiong Wang and Fengyi Zhang and Yu Shu and Hongjie Xiao and Xi Zhang and Xiaohui Ma and Jinlong Liu and Yonggang Wang and Jianhang Huang and Yongyao Xia}, doi = {10.1002/anie.202418928}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418928}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards highly stable sn2+ electrolyte for aqueous tin batteries using hydroquinone antioxidant}, volume = {64}, year = {2025}, }
• (2025). Suppressing Exciton–Vibration coupling via intramolecular noncovalent interactions for low-energy-loss organic solar cells. ANGEW, 64(7), e202418926. (www)

  @article{ , abstract = {Minimizing energy loss is crucial for breaking through the efficiency bottleneck of organic solar cells (OSCs). The main mechanism of energy loss can be attributed to non-radiative recombination energy loss (Δ E nr ) that occurs due to exciton–vibration coupling. To tackle this challenge, tuning intramolecular noncovalent interactions is strategically utilized to tailor novel fused ring electron acceptors (FREAs). Upon comprehensive analysis of both theoretical and experimental results, this approach can effectively enhance molecular rigidity, suppress structural relaxation, reduce exciton reorganization energy, and weakens exciton–vibration coupling strength. Consequently, the binary OSC device based on Y-SeSe, which features dual strong intramolecular Se ⋅ ⋅ ⋅ O noncovalent interactions, achieves an outstanding power conversion efficiency (PCE) of 19.49 %, accompanied by an extremely small Δ E nr of 0.184 eV, much lower than those of Y-SS and Y-SSe based devices with weaker intramolecular noncovalent interactions. These achievements not only set an efficiency record for selenium-containing OSCs, but also mark the lowest reported Δ E nr value among high-performance binary devices. Furthermore, the ternary blend device showcases a remarkable PCE of 20.51 %, one of the highest PCEs for single-junction OSCs. This work demonstrates the effectiveness of intramolecular noncovalent interactions in suppressing exciton–vibration coupling, thereby achieving low-energy-loss and high-efficiency OSCs.}, archive = {J_ANGEW}, author = {Xiaobin Gu and Yanan Wei and Rui Zeng and Jikai Lv and Yuqi Hou and Na Yu and Senke Tan and Zaiyu Wang and Congqi Li and Zheng Tang and Qian Peng and Feng Liu and Yunhao Cai and Xin Zhang and Hui Huang}, doi = {10.1002/anie.202418926}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418926}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Suppressing Exciton–Vibration coupling via intramolecular noncovalent interactions for low-energy-loss organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Topotactic transformation in Fe3O4 induces spontaneous growth of compositionally diverse nanostructures. ANGEW, 64(7), e202418925. (www)

  @article{ , abstract = {Topotactic transformation is an emerging strategy for synthesizing materials with exotic functional properties. In this report, instead of producing new crystals with related structures, we exploited the topotactic transformation phenomenon to spontaneously produce compositionally diverse nanostructures on the transforming substrate. The surface of magnetite nanoparticles (Fe 3 O 4 NPs) is topotactically transformed into maghemite (γ-Fe 2 O 3 ). Benefiting from such oxidation susceptibility of ultrasmall Fe 3 O 4 NPs, we achieved spontaneous growth of metals (Ag, Au, Pt, and Pd), a non-metal (Se), and a metal oxide (MnO 2 ) based nanostructures onto the surface of Fe 3 O 4 . No spontaneous growth of nanostructures was observed when the oxidized Fe 3 O 4 NPs were tested, likely due to the loss of the Fe 2+ -associated mobile electrons. The obtained nanostructures displayed appreciable antioxidant activities, which we utilized to effectively treat inflammation in the intestines. It is anticipated that this synthetic route, based on topotactic transformation, represents a significant advancement in synthesizing various chemically diverse hetero-nanostructures.}, archive = {J_ANGEW}, author = {Faheem Muhammad and Xiwen Chen and Qi Sun and Yuting Wang and Dongze Mo and Yuyang Li and Leiying Miao and Hui Wei}, doi = {10.1002/anie.202418925}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418925}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topotactic transformation in Fe3O4 induces spontaneous growth of compositionally diverse nanostructures}, volume = {64}, year = {2025}, }
• (2025). A microporous hydrogen-bonded organic framework with open pyrene sites isolated by hydrogen-bonded helical chains for efficient separation of xenon and krypton. ANGEW, 64(7), e202418917. (www)

  @article{ , abstract = {Achieving efficient xenon/krypton (Xe/Kr) separation in emerging hydrogen-bonded organic frameworks (HOFs) is highly challenging because of the lack of gas-binding sites on their pore surfaces. Herein, we report the first microporous HOF (HOF-FJU-168) based on hydrogen-bonded helical chains, which prevent self-aggregation of the pyrene core, thereby preserving open pyrene sites on the pore surfaces. Its activated form, HOF-FJU-168a is capable of separating Xe/Kr under ambient conditions while achieving an excellent balance between adsorption capacity and selectivity. At 296 K and 1 bar, the Xe adsorption capacity of HOF-FJU-168a reached 78.31 cm 3 /g, with an Xe/Kr IAST selectivity of 22.0; both values surpass those of currently known top-performing HOFs. Breakthrough experiments confirmed its superior separation performance with a separation factor of 8.6 and a yield of high-purity Kr (>99.5 %) of 184 mL/g. Furthermore HOF-FJU-168 exhibits excellent thermal and chemical stability, as well as renewability. Single-crystal X-ray diffraction and molecular modeling revealed that the unique electrostatic surface potential around the open pyrene sites creates a micro-electric field, exerting a stronger polarizing effect on Xe than on Kr, thereby enhancing host-Xe interactions.}, archive = {J_ANGEW}, author = {Lei He and Yunbin Li and Lu Li and Zhitao Wang and Yanting Chen and Furong Yuan and Gaoyan Lan and Chenxin Chen and Shengchang Xiang and Banglin Chen and Zhangjing Zhang}, doi = {10.1002/anie.202418917}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418917}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A microporous hydrogen-bonded organic framework with open pyrene sites isolated by hydrogen-bonded helical chains for efficient separation of xenon and krypton}, volume = {64}, year = {2025}, }
• (2025). Tillandsia-inspired asymmetric covalent organic framework membranes for unidirectional low-friction water collection. ANGEW, 64(7), e202418896. (www)

  @article{ , abstract = {Friction plays a pivotal role in many phenomena of physical chemistry and has long been in the focus of research thereof. As a crucial parameter, friction in membranes’ inner and/or outer surface can be minimized to reduce solvent inlet resistance and enlarge inner pore fluid flux, ideally reaching near frictionless transport of water at nanoscale. Inspired by the leaf structure of Tillandsia, a porous membrane with a rough surface and a hydrophilic inlet together with hydrophobic pore channels was designed and fabricated, based on covalent organic frameworks (COFs). Combined with COFs’ inherent highly oriented pore structures, the as-made asymmetric membranes through chemical etching can minimize the solvent critical intrusion pressure and enable inner pore low friction water transport. Ultimately, obtained COF membranes succeeded in trapping fog from air and achieved a water harvesting rate (WHR) of 1570 mg cm −2 h −1 , together with small molecular pollutants filtrated off in the meantime. Intriguingly, the synthesized asymmetric COF membranes illustrated unidirectional low friction water collecting and transporting features, the successful imitation of T. macdougallii . This work presents a practical strategy to construct functional porous membranes for low friction water collection and transport, and created a model paradigm to design fluid transporting pore channels.}, archive = {J_ANGEW}, author = {Jiaao Yao and Hongyu Zuo and Jingjie Bi and Yanjun Liu and Huiqing Wu and Jiayin Yuan and Yiwang Chen and Yaozu Liao and Weiyi Zhang}, doi = {10.1002/anie.202418896}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418896}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tillandsia-inspired asymmetric covalent organic framework membranes for unidirectional low-friction water collection}, volume = {64}, year = {2025}, }
• (2025). Vinylene-linking of polycyclic aromatic hydrocarbons to π-extended two-dimensional covalent organic framework photocatalyst for H2O2 synthesis. ANGEW, 64(7), e202418895. (www)

  @article{ , abstract = {Polycyclic aromatic hydrocarbons (PAHs) hold the predominant role either as individual molecules or building blocks in the field of organic semiconductors or nanocarbons. Connecting PAHs via sp 2 -carbon bridges to form high-crystalline π-extended structures is highly desired not only for enlarging the regimes of two-dimensional materials but also for achieving exceptional properties/functions. In this work, we developed 5,10-dimethyl-4,9-diazapyrene as a key monomer, whose two methyl groups at the positions adjacent to nitrogen atoms, can helpfully increase the solubility, and serve as the active connection sites. In the presence of organic acids, this monomer enables smoothly conducting Knoevenagel condensation to form two vinylene-linked PAH-cored COFs, which show high-crystalline honeycomb structures with large surface areas up to 1238 m 2 g −1 . Owing to the direct connection mode of PAH building blocks with vinylene, the as-prepared COFs possess spatially extended π-conjugation and substantial semiconducting properties. Consequently, their visible-light photocatalysis with exceptional activity and durability was manifested to generate H 2 O 2 up to 3820 μmol g −1 h −1 in pure water, and even 17080 μmol g −1 h −1 using benzyl alcohol as a hole sacrificial agent.}, archive = {J_ANGEW}, author = {Xu Chi and Zixing Zhang and Mengqi Li and Yang Jiao and Xiaomeng Li and Fancheng Meng and Bai Xue and Dongqing Wu and Fan Zhang}, doi = {10.1002/anie.202418895}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418895}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vinylene-linking of polycyclic aromatic hydrocarbons to π-extended two-dimensional covalent organic framework photocatalyst for H2O2 synthesis}, volume = {64}, year = {2025}, }
• (2025). The spin-selective channels in fully-exposed PtFe clusters enable fast cathodic kinetics of li-o2 battery. ANGEW, 64(7), e202418893. (www)

  @article{ , abstract = {In Li-O 2 batteries (LOBs), the electron transfer between triplet O 2 and singlet Li 2 O 2 possesses a spin-dependent character but is still neglected, while the spin-conserved electron transfer without losing phase information should guarantee fast kinetics and reduced energy barriers. Here, we provide a paradigm of spin-selective catalysis for LOB that the ferromagnetic quantum spin exchange interactions between Pt and Fe atoms in fully-exposed PtFe clusters filter directional e-spins for spin-conserved electron transfer at Fe−Fe sites. The kinetics of O 2 /Li 2 O 2 redox reaction is markedly accelerated as predicted by theoretical calculations, showing dramatically decreased relaxation time of the rate determining step for more than one order of magnitude, compared with the Fe clusters without spin-selective behavior. In consequence, the assembled LOB provides ultrahigh energy conversion efficiency of 89.6 % at 100 mA g −1 under a discharge-charge overpotential of only 0.32 V. This work provides new insights into the spin-dependent mechanisms of O 2 /Li 2 O 2 redox reaction, and the strategy of constructing spin catalysts at atomic level.}, archive = {J_ANGEW}, author = {Yuan Rao and Jiawei Yang and Jiaming Tian and Wenjie Ning and Shaohua Guo and Haoshen Zhou}, doi = {10.1002/anie.202418893}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The spin-selective channels in fully-exposed PtFe clusters enable fast cathodic kinetics of li-o2 battery}, volume = {64}, year = {2025}, }
• (2025). Catalytic enantioselective synthesis of boron-stereogenic and axially chiral BODIPYs via Rhodium(II)-catalyzed C−H (Hetero) arylation with diazonaphthoquinones and diazoindenines. ANGEW, 64(7), e202418888. (www)

  @article{ , abstract = {The molecular engineering of boron dipyrromethenes (BODIPYs) has garnered widespread attention due to their structural diversity enabling tailored physicochemical properties for optimal applications. However, catalytic enantioselective synthesis of structurally diverse boron-stereogenic BODIPYs through intermolecular desymmetrization and BODIPYs with atroposelectivity remains elusive. Here, we showcase rhodium(II)-catalyzed site-specific C−H (hetero)arylations of prochiral BODIPYs and polysubstituted BODIPYs with diazonaphthoquinonesand diazoindenines, providing efficient pathways for the rapid assembly of versatile (hetero)arylated boron-stereogenic and axially chiral BODIPYs through long-range desymmetrization and axial rotational restriction modes. The synthetic application of the procedures has been emphasized by the efficient synthesis of BODIPY derivatives with various functions. Photophysical properties, bioimaging, and lipid droplet-specific targeting capability of tailored BODIPYs are also demonstrated, indicating their promising applications in biomedical research, medicinal chemistry, and material science.}, archive = {J_ANGEW}, author = {Yankun Gao and Zizhen Liu and Sichao Tian and Ying Min and Xiangyu Li and Yuxi Chen and Xin Hong and Weidong Zhang and Lei Wang}, doi = {10.1002/anie.202418888}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418888}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic enantioselective synthesis of boron-stereogenic and axially chiral BODIPYs via Rhodium(II)-catalyzed C−H (Hetero) arylation with diazonaphthoquinones and diazoindenines}, volume = {64}, year = {2025}, }
• (2025). Ethane triggered gate-opening in a flexible-robust metal-organic framework for ultra-high purity ethylene purification. ANGEW, 64(7), e202418853. (www)

  @article{ , abstract = {Priority recognition separation of inert and larger ethane molecules from high-concentration ethylene mixtures instead of the traditional thermodynamic or size sieving strategy is a fundamental challenge. Herein, we report ethane triggered gate-opening in the flexible-robust metal-organic framework Zn(ad)(min), the 3-methylisonicotinic acid ligand can spin as a flexible gate when adsorbing the cross-section well-matched ethane molecule, achieving an unprecedented ethane adsorption capacity (62.6 cm 3 g −1 ) and ethane/ethylene uptake ratio (3.34) under low-pressure region (0.1 bar and 298 K). The ethane-induced structural transition behavior has been uncovered by a collaboration of single-crystal X-ray diffraction, in situ variable pressure X-ray diffraction and theoretical calculations, elucidating the synergetic mechanism of cross-section matching and multiple supramolecular interactions within the tailor-made pore channels. Dynamic breakthrough experiments have revealed the outstanding separation performance of Zn(ad)(min) during the production of ultra-high purity ethylene (>99.995 %) with a productivity of up to 39.2 L/kg under ambient conditions.}, archive = {J_ANGEW}, author = {Lu Zhang and Bin Yu and Meng Wang and Yang Chen and Yong Wang and Lin-Bing Sun and Yue-Biao Zhang and Zhenjie Zhang and Jinping Li and Libo Li}, doi = {10.1002/anie.202418853}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418853}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ethane triggered gate-opening in a flexible-robust metal-organic framework for ultra-high purity ethylene purification}, volume = {64}, year = {2025}, }
• (2025). “Angular” spirocyclic azetidines: Synthesis, characterization, and evaluation in drug discovery. ANGEW, 64(7), e202418850. (www)

  @article{ , abstract = {The previously neglected “angular” spirocyclic azetidines have been synthesized, characterized, and validated in drug discovery. We have shown that these compounds could act as bioisosteres for common saturated six-membered heterocycles. Their incorporation into the structure of the anticancer drug Sonidegib (instead of morpholine), and Danofloxacine (instead of piperazine) provided novel patent-free analogs with similar physicochemical properties and high activity.}, archive = {J_ANGEW}, author = {Alexander A. Kirichok and Hennadii Tkachuk and Kostiantyn Levchenko and Dmitry Granat and Tetyana Yegorova and Dmytro Lesyk and Anna Anisiforova and Yuliia Holota and Viktoriia Zomchak and Iryna Bodenchuk and Viktoriia Kosach and Petro Borysko and Rodion A. Korzh and Galeb Al-Maali and Vladimir Kubyshkin and Henry S. Rzepa and Pavel K. Mykhailiuk}, doi = {10.1002/anie.202418850}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418850}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Angular” spirocyclic azetidines: Synthesis, characterization, and evaluation in drug discovery}, volume = {64}, year = {2025}, }
• (2025). Functional characterization and molecular basis of a multi-site halogenase in naphthacemycin biosynthesis. ANGEW, 64(7), e202418843. (www)

  @article{ , abstract = {Halogenases are spurring a growing interest in the fields of biosynthesis and biocatalysis. Although various halogenases have been identified in numerous natural product biosynthetic pathways, the mechanisms for multiple halogenations and site-selectivity remain largely unclear. In this study, we biochemically characterized FasV, a flavin-dependent halogenase (FDH) that catalyzes five successive chlorinations in the biosynthesis of the naphthacene-containing aromatic polyketide naphthacemycin. This multiple halogenation reaction was elucidated to occur in an orderly fashion, as evidenced by enzyme kinetics, time-course assays, and computational simulations. Crystallographic analyses and mutagenesis studies revealed previously unrecognized amino acid residues, including T53, L81, F93, and I212, that are crucial for controlling regioselectivity and substrate specificity. Based on this, a I212T mutant was generated to exclusively catalyze selective monohalogenation. We propose a novel dual-activation mechanism and demonstrate that the larger binding pocket of FasV makes it a valuable biocatalyst for other substrates with diverse structures. Therefore, this study provides new insight into multi-site polyhalogenases and highlights the potential for engineering FasV-like FDHs for biocatalytic applications.}, archive = {J_ANGEW}, author = {Yu Hu and Shu-Ya Peng and Xueyang Ma and Hongwei Chen and Qiu-Yue Nie and Jun-Bin He and Qianqian Chen and Qiang Zhou and Xin-Hua Lu and Qiang Hua and Donghui Yang and Yong Liang and Ming Ma and Gong-Li Tang}, doi = {10.1002/anie.202418843}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418843}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functional characterization and molecular basis of a multi-site halogenase in naphthacemycin biosynthesis}, volume = {64}, year = {2025}, }
• (2025). Imperfections immobilization and regeneration in perovskite with redox-active supramolecular assembly for stable solar cells. ANGEW, 64(7), e202418834. (www)

  @article{ , abstract = {Imperfections in metal halide perovskites, such as those induced by light exposure or thermal stress, compromise device performance and stability. A key challenge is immobilizing volatile iodine produced by iodide oxidation and regenerating impurities like elemental lead and iodine. Here, we address this by integrating a redox-active supramolecular assembly of nickel octaethylporphyrin into perovskite film, functioning as both an immobilizer and redox shuttle. Decorated ethyl groups in porphyrin distorts the π ring, increasing the axial ligand adsorption capacity of central metal ion, while reducing intermolecular interactions and promoting iodine adsorption achieving a maximum uptake of 3.83 mg mg −1 to iodine. Adsorbed iodine transfers more electrons to Ni ions, leading to a weakened interaction within I−I bond and facilitating the production of iodide ions. Such a situation further enables selective oxidation of metallic lead defects to Pb 2+ . Porphyrin supramolecule facilitates hole transport across perovskite grain boundaries, leading to a champion device efficiency of 25.37 % for a 0.10 cm 2 active area, outperforms the value of control device being 23.96 %. Modified devices without encapsulation exhibit significantly enhanced stability, maintaining over 90 % of its initial performance after 1,000 hours of continuous 1-sun illumination at maximum power point at 65 °C.}, archive = {J_ANGEW}, author = {Zihan Fang and Xijiao Mu and Guo-Bin Xiao and Jing Cao}, doi = {10.1002/anie.202418834}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418834}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imperfections immobilization and regeneration in perovskite with redox-active supramolecular assembly for stable solar cells}, volume = {64}, year = {2025}, }
• (2025). Urea/Thiourea imine linkages provide accessible holes in flexible covalent organic frameworks and dominates self-adaptivity and exciton dissociation. ANGEW, 64(7), e202418830. (www)

  @article{ , abstract = {Unraveling the robust self-adaptivity and minimal energy-dissipation of soft reticular materials for environmental catalysis presents a compelling yet unexplored avenue. Herein, a top-down strategy, tailoring from the unique linkage basis, flexibility degree, skeleton electronics to trace-guest adaptability, is proposed to fill the understanding gap between micro-soft covalent organic frameworks (COFs) and photocatalytic performance. The thio(urea)-basis-dominated linkage within benzotrithiophene-based COFs induce the framework contraction/swelling (intralayer micro-flexibility) in response to tetrahydrofuran or water. Adaptability of micro-flexible thiourea-COF with pore hydrophilicity not only contributes to the favorable mass transfer, but also enhances the accessible redox active sites, culminating in nearly 100 % removal of micropollutant with low-energy dissipation in wastewater. The incorporating urea/thiourea into imine linkage facilitates polarization reduction and exciton dissociation within skeleton wall, inducing strong localization for holes. This transformation facilitates interchain charge transport and unbalanced distribution conducive to oxidative holes-mediated micropollutant decomposition.}, archive = {J_ANGEW}, author = {Chencheng Qin and Xiaodong Wu and Wenyan Zhou and Miao Li and Shuai Bi and Lin Tang and Hao Huang and Wenguang Tu and Xingzhong Yuan and Edison Huixiang Ang and Weiling Sun and Long Chen and Zhaoli Liu and Bing He and Lai Lyu and Yan Wu and Wen Liu and Hou Wang}, doi = {10.1002/anie.202418830}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Urea/Thiourea imine linkages provide accessible holes in flexible covalent organic frameworks and dominates self-adaptivity and exciton dissociation}, volume = {64}, year = {2025}, }
• (2025). A universal design of lithium anode via dynamic stability strategy for practical all-solid-state batteries. ANGEW, 64(7), e202418811. (www)

  @article{ , abstract = {All-solid-state Li-metal battery (ASSLB) chemistry with thin solid-state electrolyte (SSE) membranes features high energy density and intrinsic safety but suffers from severe dendrite formation and poor interface contact during cycling, which hampers the practical application of rechargeable ASSLB. Here, we propose a universal design of thin Li-metal anode (LMA) via a dynamic stability strategy to address these issues. The ultra-thin LMA (20 μm) is in situ constructed with uniform highly Li-ion conductive solid-electrolyte interphase and composite-polymer interphase (CPI) via electroplating process. As a result, the passivation layer with poor Li-ion conduction on Li anode can be dissolved and small surface resistance can be achieved due to the good compatibility of CPI to SSEs. The cycling of Li symmetric cell with Li 6 PS 5 Cl thin film electrolyte (<100 μm) shows a high critical current density of >2.0 mA cm −2 with excellent cycling stability at 1.0 mA cm −2 . The ASSLBs paring with Ni-rich LiNi 0.6 Mn 0.2 Co 0.2 O 2 cathode demonstrated the feasibility of engineered LMA design by presenting good rate capability from 0.1 C to 1.0 C at room temperature, as well as long-term cycling stability (81 % retention after 100 cycles). This work represents a general pathway to make thin dendrite-free LMA available for high-energy-density ASSLBs.}, archive = {J_ANGEW}, author = {Tao Deng and Changhong Wang and Hongli Wan and Ai-Min Li and Xinzi He and Zeyi Wang and Longsheng Cao and Xiulin Fan and Chunsheng Wang}, doi = {10.1002/anie.202418811}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A universal design of lithium anode via dynamic stability strategy for practical all-solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). NIR-II Fluorescence/Photoacoustic dual ratiometric probes with unique recognition site for quantitatively visualizing H2S2 in vivo. ANGEW, 64(7), e202418378. (www)

  @article{ , abstract = {Hydrogen persulfide (H 2 S 2 ) plays a significant role in redox biology and signal transduction; therefore, quantitative visualization of H 2 S 2 in the deep tissue of living organisms is essential for obtaining reliable information about relevant pathophysiological processes directly. However, currently reported H 2 S 2 probes are unsuitable for this purpose because of their poor selectivity for many polysulfide species or their short wavelength, which hinders precise imaging in deep tissues. Herein, for the first time, we report a unique H 2 S 2 -mediated dithiole formation reaction. Based on this reaction, we construct the first NIR-II fluorescence (FL) and photoacoustic (PA) dual-ratiometric probe ( NIR-II-H 2 S 2 ) for quantitatively visualizing H 2 S 2 in vivo. This probe shows dual-ratiometric NIR-II fluorescence (I 840 /I 1000 , 107-fold) and photoacoustic (PA 800 /PA 900 , 6.5-fold) responses towards Na 2 S 2 species with high specificity, excellent sensitivity (1.8 nM), improved water solubility, and deep-tissue penetration. More importantly, using NIR-II dual-ratiometric FL/PA imaging, we successfully demonstrated that the probe could be used to accurately quantify the fluctuating H 2 S 2 levels in the liver-injury mouse models induced by lipopolysaccharides or metformin drugs. Overall, this study not only presents a promising tool for H 2 S 2 -related pathological research, but also provides a unique recognition site that may be generalized for designing more useful H 2 S 2 imaging agents in the future.}, archive = {J_ANGEW}, author = {Bangping Hu and Qinian Liu and Yulan Jiang and Yujie Huang and Huiquan Ji and Jiqi Zhang and Xia Wang and Xing-Can Shen and Hua Chen}, doi = {10.1002/anie.202418378}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418378}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NIR-II Fluorescence/Photoacoustic dual ratiometric probes with unique recognition site for quantitatively visualizing H2S2 in vivo}, volume = {64}, year = {2025}, }
• (2025). Artificial lithium channels built from polymers with intrinsic microporosity. ANGEW, 64(7), e202418304. (www)

  @article{ , abstract = {In sharp contrast to numerous artificial potassium channels developed over the past decade, the study of artificial lithium-transporting channels has remained limited. We demonstrate here the use of an interesting class of polymers with intrinsic microporosity (PIM) for constructing artificial lithium channels. These PIM-derived lithium channels show exceptionally efficient (γ Li + >40 pS) and highly selective transport of Li + ions, with selectivity factors of>10 against both Na + and K + . By simply adjusting the initial reaction temperature, we can tune the transport property in a way that PIMs synthesized at initial reaction temperatures of 60 °C and 80 °C exhibit improved transport efficiency and selectivity, respectively, in the dioleoyl phosphatidylcholine membrane.}, archive = {J_ANGEW}, author = {Fei Gou and Qiuting Wang and Zihong Yang and Wenju Chang and Jie Shen and Huaqiang Zeng}, doi = {10.1002/anie.202418304}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202418304}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial lithium channels built from polymers with intrinsic microporosity}, volume = {64}, year = {2025}, }
• (2025). Tandem-controlled dynamic DNA assembly enables temporally-selective orthogonal regulation of cGAS–STING stimulation. ANGEW, 64(7), e202417916. (www)

  @article{ , abstract = {Despite advances in the controlled reconfiguration of DNA structures for biological applications, the dearth of strategies that allow for orthogonal regulation of immune pathways remains a challenge. Here, we report for the first time an endogenous and exogenous tandem-regulated DNA assembly strategy that enables orthogonally controlled stimulation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. A DNA motif containing two palindromic sequences is engineered with an abasic site (AP)-connected blocking sequence to inhibit its self-assembly function, while apurinic/apyrimidinic endonuclease 1 (APE1)-triggered enzymatic cleavage of the AP site enables the reconfiguration and self-assembly of DNA motif into long double-stranded structures, thus realizing allosteric activation of the catalytic activity of cGAS to produce 2’3’-cyclic-GMP-AMP for STING stimulation. Importantly, we demonstrate that APE1-regulated DNA assembly allows for cell-selective activation of cGAS–STING signaling. Furthermore, by re-engineering the DNA motif with a photocleavable group, enzyme-triggered DNA assembly allows the cGAS–STING stimulation to operate (switched “ON”), whereas light-mediated fragmentation of the double-stranded DNA enables termination of such stimulation (switched “OFF”), thereby achieving orthogonal control over immune regulation. This work highlights an endogenous and exogenous tandem regulated strategy to modulate the cGAS–STING pathway in an orthogonally controlled manner.}, archive = {J_ANGEW}, author = {Xiangfei Li and Fangzhi Yu and Lele Li}, doi = {10.1002/anie.202417916}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202417916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem-controlled dynamic DNA assembly enables temporally-selective orthogonal regulation of cGAS–STING stimulation}, volume = {64}, year = {2025}, }
• (2025). Adsorbate resonance induces water-metal bonds in electrochemical interfaces. ANGEW, 64(7), e202417308. (www)

  @article{ , abstract = {This study delves into the intricate interactions between surface-near species, OH and H 2 O, on electrodes in electrochemical interfaces. These species are an inevitable part of many electrocatalytic energy conversion reactions such as the oxygen reduction reaction. In our modeling, we utilize high statistics on a dataset of complex solid solutions with high atomic variability to show the emergence of H 2 O-metal covalent bonds under specific conditions. Based on density functional theory (DFT) calculations of adsorption energies on many thousands of different surface compositions, we provide a quantifiable physical understanding of this induced water covalency, which is rooted in simple quantum mechanics. Directional hydrogen bonding between surface-near H 2 O and OH, enables surface bonding electrons to delocalize, mediated by near-symmetrical adsorbate resonance structures. The different adsorbate resonance structures differ by surface coordination explaining the induced H 2 O-metal bonding.}, archive = {J_ANGEW}, author = {Marcus F. Nygaard and Martin L. S. Nielsen and Jan Rossmeisl}, doi = {10.1002/anie.202417308}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202417308}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Adsorbate resonance induces water-metal bonds in electrochemical interfaces}, volume = {64}, year = {2025}, }
• (2025). Organic molecule functionalization enables selective electrochemical reduction of dilute CO2 feedstock. ANGEW, 64(7), e202417196. (www)

  @article{ , abstract = {The electrochemical conversion of low-concentration CO 2 feedstock to value-added chemicals and fuels is a promising pathway for achieving direct valorization of waste gas streams. However, this is challenging due to significant competition from the hydrogen evolution reaction (HER) and lowered CO 2 reduction (CO 2 R) kinetics as compared to systems that employ pure CO 2 . Here we show that terephthalic acid (TPA) functionalization can boost selectivity towards CO 2 R and suppress HER over a range of catalysts including Bi, Cu and Zn. For instance, TPA functionalized Bi attained a formate Faradaic efficiency (FE HCOO- ) of 96.3 % at 300 mA cm −2 with pure CO 2 feedstock. Density functional theory simulations indicate that this is because TPA functionalization modulates the binding energies of the key reaction intermediates *OCHO and *H. With low-concentration feedstock (15 % CO 2 ) at 100 mA cm −2 , we achieved a high FE HCOO- of 85.8 %, which was double that of an unmodified Bi catalyst. Using an electrolyzer with a porous solid electrolyte layer, we successfully showcase 30 h of continuous high-purity formic acid production with a 5 % CO 2 feed. Taken together, our findings demonstrate that molecular tuning of a catalyst can be an effective strategy for enabling selective CO 2 R using low-concentration feedstock.}, archive = {J_ANGEW}, author = {Bingqing Wang and Xingyu Wang and Bo Wu and Peize Li and Shenghua Chen and Ruihu Lu and Weifei Lai and Yan Shen and Zechao Zhuang and Jiexin Zhu and Ziyun Wang and Dingsheng Wang and Yanwei Lum}, doi = {10.1002/anie.202417196}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202417196}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic molecule functionalization enables selective electrochemical reduction of dilute CO2 feedstock}, volume = {64}, year = {2025}, }
• (2025). Batrachopolyenes: Volatile norsteroids from femoral scent glands of frogs. ANGEW, 64(7), e202417098. (www)

  @article{ , abstract = {Steroid hormones are C 18 -C 21 -sterane derivatives, featuring the typical 6–6–6–5 ring system. Here we report on a novel C 18 -steroid ring system named batrachane with a contracted A-ring resulting in a 5–6–6–5 ring arrangement. The isolation, structural elucidation, and total synthesis of three members of the novel batrachopolyene family occurring in the tropical frog genus Odontobatrachus is reported. The batrachopolyenes represent an entirely new collection of volatile steroidal natural products produced by anuran amphibians. Alongside the contracted A-ring, each member contains a Δ 16-17 double bond but differs in the central belt of the steroidal structure. To create these atypical structural features, syntheses featuring a combination of Breslow radical chain relay chlorination, Favorskii ring contraction, and Clemmensen reduction proved successful. The occurrence of such compounds in another distal anuran group, the Mantellinae, suggests a more widespread distribution of the batrachane-type compounds among frogs. The new structural steroid type raises questions concerning steroid biosynthesis and reception, as well as distribution in frogs in general and the structures of their hormones.}, archive = {J_ANGEW}, author = {Matthew Stell and Kristina Melnik and Christian Schlawis and Roman Fuchs and Miguel Vences and Marvin Schäfer and Mark-Oliver Rödel and Stefan Schulz}, doi = {10.1002/anie.202417098}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202417098}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Batrachopolyenes: Volatile norsteroids from femoral scent glands of frogs}, volume = {64}, year = {2025}, }
• (2025). Organoboron-functionalized metal-organic nanosheets for highly efficient CO2 fixation mediated by frustrated lewis pairs. ANGEW, 64(7), e202416497. (www)

  @article{ , abstract = {Converting CO 2 to high-value fine chemicals represents one of the most promising approaches to combat global warming and subsequently achieve a sustainable carbon cycle. Herein, we contribute an organoboron functionalized ultra-thin metal-organic nanosheet (MON), termed TCPB-Zr-NS, featuring an abundance of exposed Lewis acidic B and formate sites, which can effectively promote CO 2 conversion upon the addition of Lewis basic o-phenylenediamines. Compared with the prototypical 3D analogue TCPB-Zr-3D, the resultant TCPB-Zr-NS showcases dramatically improved catalytic activity for the cyclization of o-phenylenediamine as a result of the highly exposed active sites and efficient substrates/products diffusion. Strikingly, the incorporation of Lewis acidic B sites into ultra-thin Zr-based MON (Zr-MON) not only promotes the highly efficient CO 2 conversion, but also enhances the recyclability/durability of catalysts. Additionally, the underlying catalytic mechanism has been well established by the comprehensive experiments and theoretical calculations, unveiling a formate-assisted frustrated Lewis pairs (FLP) mediated catalytic pathway. This work opens up a new avenue to heterogeneous FLP-based catalysts for small molecule activation and beyond.}, archive = {J_ANGEW}, author = {Cheng-Xia Chen and Haiping Wang and Hassan Rabaâ and Yang-Yang Xiong and Peter VanNatta and Zhang-Wen Wei and Abdullah M. Al-Enizi and Ayman Nafady and Shengqian Ma}, doi = {10.1002/anie.202416497}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202416497}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organoboron-functionalized metal-organic nanosheets for highly efficient CO2 fixation mediated by frustrated lewis pairs}, volume = {64}, year = {2025}, }
• (2025). Modular photoswitchable molecular glues for chemo-optogenetic control of protein function in living cells. ANGEW, 64(7), e202416456. (www)

  @article{ , abstract = {Optogenetic systems using photosensitive proteins and chemically induced dimerization/proximity (CID/CIP) approaches enabled by chemical dimerizers (also termed molecular glues), are powerful tools to elucidate the dynamics of biological systems and to dissect complex biological regulatory networks. Here, we report a versatile chemo-optogenetic system using modular, photoswitchable molecular glues (sMGs) that can undergo repeated cycles of optical control to switch protein function on and off. We use molecular dynamics (MD) simulations to rationally design the sMGs and further expand their scope by incorporating different photoswitches, resulting in sMGs with customizable properties. We demonstrate that this system can be used to reversibly control protein localization, organelle positioning, protein-fragment complementation as well as posttranslational protein levels by light with high spatiotemporal precision. This system enables sophisticated optical manipulation of cellular processes and thus opens up a new avenue for chemo-optogenetics.}, archive = {J_ANGEW}, author = {Jun Zhang and Laura K. Herzog and Dale P. Corkery and Tzu-Chen Lin and Laura Klewer and Xi Chen and Xiaoyi Xin and Yaozong Li and Yao-Wen Wu}, doi = {10.1002/anie.202416456}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202416456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular photoswitchable molecular glues for chemo-optogenetic control of protein function in living cells}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bonded supramolecular network enabled gentle reprogramming of liquid crystal elastomer toward evolutionary robot. ANGEW, 64(7), e202416095. (www)

  @article{ , abstract = {In nature, many organisms augment chances of survival by reprogramming their structures to evolving environment, among which sea squirts being a prime example. Such reprogramming has been demonstrated in liquid crystal elastomer (LCE) actuator assembled with heat assistance. However, the required temperature being higher than the actuation temperature limits its application. Here, we reported a hydrogen-bonded supramolecular network LCE to construct soft modular and reprogrammable actuator by assembling with a gentle heat treatment. Leveraging the Michael addition reaction, we introduced hydrogen bonding to the LCE matrix with functionalized pyridine monomers. Experimental and molecular dynamics modeling proved the efficient dynamic hydrogen bond exchange at 60 °C, significantly lower than the actuating temperature of the LCE. This gave rise to the reversible and robust adhesion of the same collection of LCE modules capable of being built into different bilayers and performing various morphing upon a short thermal stimulation. Therefore, we demonstrated that these comparatively weak cross-links enabled reconfiguration of the LCE actuator. With the developed hydrogen-bonding LCEs, we built proof-of-concept modular reprogrammable robot, performing crawling, sailing, and microcircuit repair tasks. This bioinspired and efficient method for evolutionary LCE robot offers a viable path for further development of intelligent actuators sustainable in complex environments.}, archive = {J_ANGEW}, author = {Zhenxing Wang and Muqing Si and Junyi Han and Ying Shen and Guangqiang Yin and Kaiyang Yin and Peng Xiao and Tao Chen}, doi = {10.1002/anie.202416095}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202416095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bonded supramolecular network enabled gentle reprogramming of liquid crystal elastomer toward evolutionary robot}, volume = {64}, year = {2025}, }
• (2025). Tailoring the properties of chemically recyclable polyethylene-like multiblock polymers by modulating the branch structure. ANGEW, 64(7), e202415707. (www)

  @article{ , abstract = {Developing plastics that fill the need of polyolefins yet are more easily recyclable is a critical need to address the plastic waste crisis. However, most efforts in this vein have focused on high-density polyethylene (PE), while many different types of PE exist. To create broadly sustainable PE with modular properties, we present the synthesis, characterization, and demonstration of materials applications for chemically recyclable PE-like multiblock polymers prepared from distinct hard and soft blocks using ruthenium-catalyzed dehydrogenative polymerization. By altering the branching pattern within the soft blocks, a series of PE-like multiblock polymers were synthesized with tunable glass transition temperatures ( T g ) while maintaining consistent high melting temperatures ( T m ). A clear U-shape trend between T g and mechanical properties was found, showcasing their potential as sustainable materials with tailored properties spanning commercial linear low-density polyethylene (LLDPE) and low-density polyethylene (LDPE). These materials offer adjustable adhesive strength to metal and demonstrate chemical recyclability and selective depolymerization in mixed plastic streams, promoting circularity and separation.}, archive = {J_ANGEW}, author = {Yucheng Zhao and Emma M. Rettner and Megan E. Battson and Zhitao Hu and Joel Miscall and Nicholas A. Rorrer and Garret M. Miyake}, doi = {10.1002/anie.202415707}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202415707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring the properties of chemically recyclable polyethylene-like multiblock polymers by modulating the branch structure}, volume = {64}, year = {2025}, }
• (2025). A photosynthesis-derived bionic system for sustainable biosynthesis. ANGEW, 64(7), e202414981. (www)

  @article{ , abstract = {“Cell factory” strategy based on microbial anabolism pathways offers an intriguing alternative to relieve the dependence on fossil fuels, which are recognized as the main sources of CO 2 emission. Typically, anabolism of intracellular substance in cell factory requires the consumption of sufficient reduced nicotinamide adenine dinucleotide /nicotinamide adenine dinucleotide phosphate NAD(P)H and adenosine triphosphate ATP. However, it is of great challenge to modify the natural limited anabolism and to increase the insufficient level of NAD(P)H and ATP to optimum concentrations without causing metabolic disorder. Inspired by the natural photosynthesis process in which NAD(P)H and ATP can both be produced through the coupled electron-proton transfer processes driven by sunlight, herein we designed a light-driven bionic system composed of three modules including photo-induced electron module, electron transfer channel module and proton gradient module. The proposed strategy of light-driven bionic system enables for achieving simultaneous and controllable supplies of NAD(P)H and ATP, thus facilitating both highly efficient CO 2 fixation and biomanufacturing. The proposed light-driven bionic system design strategy in this work might pave new sustainable ways for reducing power and energy regeneration to optimize microbial metabolism, offering intriguing alternatives for CO 2 emission mitigation and high-value chemical biomanufacturing.}, archive = {J_ANGEW}, author = {Na Chen and Ruichen Shen and Tianpei He and Jing Xi and Rui Zhao and Na Du and Yangbing Yang and Lilei Yu and Quan Yuan}, doi = {10.1002/anie.202414981}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202414981}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A photosynthesis-derived bionic system for sustainable biosynthesis}, volume = {64}, year = {2025}, }
• (2025). Water-soluble aromatic nanobelt with unique cellular internalization. ANGEW, 64(7), e202414645. (www)

  @article{ , abstract = {A water-soluble aromatic nanobelt was synthesized, and its cellular uptake behavior in HeLa cells was investigated. The late-stage functionalization of the parent methylene-bridged [6]cycloparaphenylene ([6]MCPP) provided an easily accessible alkyne-functionalized nanobelt in a single reaction step. The alkyne-substituted [6]MCPP was subjected to Cu-catalyzed azide–alkyne cycloaddition by using a dye-attached azide to obtain a water-soluble aromatic nanobelt. Cell-imaging experiments on the synthesized nanobelt in HeLa cells revealed stop-and-go cellular uptake dynamics. Similar experiments with control molecules and theoretical studies indicated that the unique dynamics of the nanobelt was derived from the belt-shaped structure.}, archive = {J_ANGEW}, author = {Konstantin Günther and Hideya Kono and Hiroki Shudo and Daisuke Shimizu and Reika Isoda and Masayoshi Nakamura and Akiko Yagi and Kazuma Amaike and Kenichiro Itami}, doi = {10.1002/anie.202414645}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202414645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Water-soluble aromatic nanobelt with unique cellular internalization}, volume = {64}, year = {2025}, }
• (2025). A tetrazine amplification system for visual detection of trace analytes via click-release reactions. ANGEW, 64(7), e202414246. (www)

  @article{ , abstract = {Achieving visual detection of analytes at ultra-low concentrations in complex mixtures remains a persistent challenge. While sophisticated techniques offer single-molecule sensitivity, practical hurdles remain, necessitating tailored signal amplification systems for direct visual detection. In this study, we develop a strategy for the visualized detection of tetrazine through a “click-release-oxidation-cycle” (CROC) cascade amplification process. We systematically describe the construction and synthesis of this system, the kinetic process of click release, the kinetics of oxidation to tetrazine and its cascade amplification effect in trace amounts of tetrazine. This system is capable of amplifying the signal of tetrazine at a concentration as low as 2 nM by 10 5 -fold, thereby providing a clearly visible purple signal. Finally, as proof of concept, we successfully apply this method to visually detect trace β -galactosidase ( β -gal) and Pd 2+ .}, archive = {J_ANGEW}, author = {Jing Li and Mingxin Cheng and Hongbo Zhang and Yichen Wang and Weiwei Guo and Yueqin Zheng}, doi = {10.1002/anie.202414246}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202414246}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A tetrazine amplification system for visual detection of trace analytes via click-release reactions}, volume = {64}, year = {2025}, }
• (2025). Highly efficient and stable perovskite solar cells by introducing a multifunctional surface modulator. ANGEW, 64(7), e202413660. (www)

  @article{ , abstract = {Simultaneously passivating the perovskite surface defects and suppressing Li + ions diffusion of hole transport layer (HTL) are still challenging issues. Herein, we report an effective “ three birds with one stone ” strategy by utilizing sodium 4,4′-(1,4-phenylenebis(oxy))bis(butane-1-sulfonate) (ZR3) containing sulfonic acid groups (SO 3 − ) and Na + ions as a multifunctional surface treatment modulator to simultaneously address the above issues. It is found that ZR3 is not only capable of passivating the Pb-related defects at the surface of perovskite by the SO 3 − group, but also possesses the remarkable ability to passivate the halide defects with Na + ions. Meanwhile, ZR3 treatment enables the enhanced exciton dissociation of perovskite, better energy level alignment with hole transport layer (HTL), improved hole extraction/transfer from perovskite layer into HTL, and reduced charge carrier recombination in device. Therefore, it results in the enhanced power conversion efficiency (PCE) of 25.34 % in ZR3-based n-i-p device from 22.97 % for the control device. Specifically, p-i-n PSCs with ZR3 also achieves an improved PCE of 25.96 % with respect to the pristine one (23.99 %), proving the universality of ZR3 for PSCs. Moreover, the stabilities of ZR3-treated devices are significantly enhanced owing to Li + ions migration suppressing and perovskite defects reduction.}, archive = {J_ANGEW}, author = {Rongshan Zhuang and Peng Wang and Linqin Wang and Qian Lai and Junming Qiu and Yinjuan Chen and Xiaoliang Zhang and Licheng Sun and Yong Hua}, doi = {10.1002/anie.202413660}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {7}, pages = {e202413660}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient and stable perovskite solar cells by introducing a multifunctional surface modulator}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Total syntheses of β- and γ-naphthocyclinones. ANGEW, 64(6), e202580662. (www)

  @article{ , archive = {J_ANGEW}, author = {Yoshio Ando and Taiju Hoshino and Nozomi Tanaka and Mark M. Maturi and Yusuke Nakazawa and Takumi Fukazawa and Ken Ohmori and Keisuke Suzuki}, doi = {10.1002/anie.202580662}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202580662}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Total syntheses of β- and γ-naphthocyclinones}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Heavy pentaisopropylcyclopentadienyltriylenes and their heterobimetallic complexes. ANGEW, 64(6), e202580661. (www)

  @article{ , archive = {J_ANGEW}, author = {Inga-Alexandra Bischoff and Bernd Morgenstern and Michael Zimmer and André Schäfer}, doi = {10.1002/anie.202580661}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202580661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Heavy pentaisopropylcyclopentadienyltriylenes and their heterobimetallic complexes}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Localized oxidative catalytic reactions triggered by cavitation bubbles confinement on copper oxide microstructured particles. (Angew. chem. int. ed. 6/2025). ANGEW, 64(6), e202424920. (www)

  @article{ , archive = {J_ANGEW}, author = {Valarmathi Mahendran and Quang Thang Trinh and Xie Zhangyue and Umesh Jonnalagadda and Tim Gould and Nam-Trung Nguyen and James Kwan and Tej S. Choksi and Wen Liu and Sabine Valange and François Jérôme and Prince Nana Amaniampong}, doi = {10.1002/anie.202424920}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202424920}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Localized oxidative catalytic reactions triggered by cavitation bubbles confinement on copper oxide microstructured particles. (Angew. chem. int. ed. 6/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: An angstrom-scale protective skin grown in situ on perovskite oxide to enhance stability in water (Angew. chem. int. ed. 6/2025). ANGEW, 64(6), e202424618. (www)

  @article{ , archive = {J_ANGEW}, author = {Wanglin Zhou and Fang Xu and Jinkun Tan and Zhengkun Liu and Guangru Zhang and Zhi Xu and Yinong Lyu and Wanqin Jin}, doi = {10.1002/anie.202424618}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202424618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: An angstrom-scale protective skin grown in situ on perovskite oxide to enhance stability in water (Angew. chem. int. ed. 6/2025)}, volume = {64}, year = {2025}, }
• (2025). André schäfer. ANGEW, 64(6), e202424599. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202424599}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202424599}, shortjournal = {Angew. Chem. Int. Edit.}, title = {André schäfer}, volume = {64}, year = {2025}, }
• (2025). Paweł borowiecki. ANGEW, 64(6), e202424488. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202424488}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202424488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Paweł borowiecki}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Synthesis of low-molecular-weight fucoidan analogue and its inhibitory activities against heparanase and SARS-CoV-2 infection (Angew. chem. int. ed. 6/2025). ANGEW, 64(6), e202423694. (www)

  @article{ , archive = {J_ANGEW}, author = {Aoi Sugimoto and Tatsuki Koike and Yuya Kuboki and Sumika Komaba and Shuhei Kosono and Maniyamma Aswathy and Itsuki Anzai and Tokiko Watanabe and Kazunobu Toshima and Daisuke Takahashi}, doi = {10.1002/anie.202423694}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202423694}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Synthesis of low-molecular-weight fucoidan analogue and its inhibitory activities against heparanase and SARS-CoV-2 infection (Angew. chem. int. ed. 6/2025)}, volume = {64}, year = {2025}, }
• (2025). Back cover: Unveiling the influence of oxygen on drug release dynamics in semipermeable polymersomes (Angew. chem. int. ed. 6/2025). ANGEW, 64(6), e202423688. (www)

  @article{ , archive = {J_ANGEW}, author = {Matteo Tollemeto and Pascal L. W. Welzen and Lasse H E. Thamdrup and Yudong Li and Tania Patiño Padial and Anja Boisen and Jan van Hest}, doi = {10.1002/anie.202423688}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202423688}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Unveiling the influence of oxygen on drug release dynamics in semipermeable polymersomes (Angew. chem. int. ed. 6/2025)}, volume = {64}, year = {2025}, }
• (2025). Low-dimensional lead-free metal halides for efficient electrically driven light-emitting diodes. ANGEW, 64(6), e202423185. (www)

  @article{ , abstract = {Electrically driven light-emitting diodes (ED LEDs) based on 3D metal halide perovskites have seen remarkable advancements during the past decade. However, the highest-performing devices are largely based on lead-containing 3D perovskites, presenting two key challenges – toxicity and stability – that must be addressed for commercialization. Reducing structural dimensionality and incorporating non-lead metals present promising pathways to address these issues. Although research on ED LEDs based on low-dimensional, lead-free metal halides (LD LFMHs) is growing, their performance still significantly lags behind that of 3D lead halide perovskites. This review seeks to deliver a comprehensive overview of ED LEDs based on LD LFMHs, covering a brief history of their development, methods for material synthesis, luminescence mechanisms, and applications in electroluminescent devices. It also examines current challenges and proposes practical strategies to enhance device performance, with the goal of inspiring further progress in the field.}, archive = {J_ANGEW}, author = {Jia-Yu Yao and He Liu and Zhong-Ning Chen and Biwu Ma and Liang-Jin Xu}, doi = {10.1002/anie.202423185}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202423185}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-dimensional lead-free metal halides for efficient electrically driven light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Two-dimensional conjugated Metal–Organic frameworks for photochemical transformations. ANGEW, 64(6), e202422382. (www)

  @article{ , abstract = {Photochemical transformation represents an attractive pathway for the conversion of earth-abundant resources, such as H 2 O, CO 2 , O 2 , and N 2 , into valuable chemicals by utilizing sunlight as an energy source. Recently, two-dimensional conjugated metal–organic frameworks (2D c -MOFs) have emerged as the focal points in the field of photo-to-chemical conversion due to their advantages in light harvesting, electrical conductivity, mass transport, tunable electronic and porous structures, as well as abundant active sites. In this review, we highlight various physical and chemical features of 2D c -MOFs that can contribute to enhanced photo-induced exciton generation, charge transport, proton migration and redox catalysis. Then, the existing strategies to integrate suitable light absorbers and/or co-catalysts onto 2D c -MOFs for photochemical transformations (with a particular focus on H 2 evolution, CO 2 reduction and O 2 reduction) have been discussed. Finally, the challenges and opportunities of using 2D c -MOFs in other photochemical applications (e.g., N 2 fixation, organic synthesis, and environmental remediation) are assessed.}, archive = {J_ANGEW}, author = {Huilan Yang and Yi Liu and Mingchao Wang and Zhixuan Zhang and Yong-Chao Zheng and Xu-Bing Li and Li-Zhu Wu and Xinliang Feng and Huaping Wang}, doi = {10.1002/anie.202422382}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202422382}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-dimensional conjugated Metal–Organic frameworks for photochemical transformations}, volume = {64}, year = {2025}, }
• (2025). Host-in-host complexation: Activating classical hosts through complete encapsulation within an M9L6 coordination cage. ANGEW, 64(6), e202422143. (www)

  @article{ , abstract = {This study reports a method for enhancing the functions and properties of traditional organic macrocyclic hosts by fully encapsulating them within a large M 9 L 6 cage to form host-in-host complexes. Within the cage host, the macrocyclic organic hosts with electron-rich aromatic rings, such as cyclotriveratrylene and calix[8]arene, adopt specific orientations enhancing their inherent molecular recognition abilities. Due to the high crystallinity of the M 9 L 6 cage, the guest encapsulation behavior of the host-in-host complexes can be observed by X-ray structural analysis.}, archive = {J_ANGEW}, author = {Kenta Iizuka and Hiroki Takezawa and Makoto Fujita}, doi = {10.1002/anie.202422143}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202422143}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Host-in-host complexation: Activating classical hosts through complete encapsulation within an M9L6 coordination cage}, volume = {64}, year = {2025}, }
• (2025). Regioisomeric π-extended nanographene with long-lived phosphorescence afterglow. ANGEW, 64(6), e202422125. (www)

  @article{ , abstract = {The cutouts of graphene sheets, particularly those with a nonplanar topology, present vast opportunities for advancement. Even a slight deviation from the planar structure can lead to intriguing (chiro)optical features for helically twisted nanographenes. In this context, we introduce two regioisomeric π-extended nanographenes that exhibit distinct excited-state characteristics. The helicene structure and the photophysical features can be easily tuned by changing the connecting position of the nanographene to the carbazole core (2,7− and 3,6−). Single-crystal X-ray diffraction analysis confirmed the formation of nanographenes with bent and helical conformations. Both derivatives exhibited thermally activated delayed fluorescence at room temperature and phosphorescence at low temperatures. Notably, the nanographene with the bent structure displayed an impressive red afterglow lasting over 30 seconds, in contrast to the very weak afterglow observed in the helical structure. DFT calculations revealed the existence of an isoenergetic higher triplet state (T 8 ) and comparatively weak spin-orbit coupling (T 1 -S 0 ), thereby enabling the bent nanographene to exhibit a long-lived component and strong afterglow. Our findings highlight the significance of regioisomeric nanographenes with exceptional optical properties and offer a deeper understanding of the structure–property relationship in nonplanar nanographenes.}, archive = {J_ANGEW}, author = {Viksit Kumar and Geethu Venugopal and Ashok Badrinarayan Jadhav and Sangram D. Dongre and Rajesh Gonnade and Jatish Kumar and Paul C. Ruer and Benjamin Hupp and Andreas Steffen and Sukumaran Santhosh Babu}, doi = {10.1002/anie.202422125}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202422125}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioisomeric π-extended nanographene with long-lived phosphorescence afterglow}, volume = {64}, year = {2025}, }
• (2025). A scalable pore-space-partitioned metal-organic framework powered by polycatenation strategy for efficient acetylene purification. ANGEW, 64(6), e202421992. (www)

  @article{ , abstract = {Efficient separation of acetylene (C 2 H 2 ) from carbon dioxide (CO 2 ) and ethylene (C 2 H 4 ) is a significant challenge in the petrochemical industry due to their similar physicochemical properties. Pore space partition (PSP) has shown promise in enhancing gas adsorption capacity and selectivity by reducing pore size and increasing the density of guest binding sites. Herein, we firstly employ the 2D→3D polycatenation strategy to construct a PSP metal-organic framework (MOF) Ni-dcpp-bpy , incorporating functional N/O sites to enhance C 2 H 2 purification. The polycatenated framework with optimized pore size and regularity, exhibiting significant improvements over traditional PSP MOFs by resolving the critical contradiction of balancing C 2 H 2 uptake (98.5 cm 3 g −1 at 298 K, 100 kPa) and selectivity of C 2 H 2 /CO 2 (3.4), C 2 H 2 /C 2 H 4 (5.9), and C 2 H 2 /CH 4 (96.4) in a MOF. Breakthrough experiments confirm high-purity C 2 H 4 (>99.9 %) and high C 2 H 2 productivity from binary and ternary mixtures. Notably, Ni-dcpp-bpy exhibits excellent water stability, scalability, and regenerability after 20 cycles for separating C 2 H 2 /CO 2 . Theoretical calculations verify that the strong binding of C 2 H 2 is mainly attributed to the C−H⋅⋅⋅O/N interactions between host Ni-dcpp-bpy and guest C 2 H 2 molecules. The polycatenation strategy not only improved industrial C 2 H 2 purification efficiency but also enriched the design diversity of customized MOFs for other gas separation applications.}, archive = {J_ANGEW}, author = {Zhen-Hua Guo and Xue-Qian Wu and Ya-Pan Wu and Dong-Sheng Li and Guo-Ping Yang and Yao-Yu Wang}, doi = {10.1002/anie.202421992}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421992}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A scalable pore-space-partitioned metal-organic framework powered by polycatenation strategy for efficient acetylene purification}, volume = {64}, year = {2025}, }
• (2025). Self-assembled bent perylenediimides. ANGEW, 64(6), e202421871. (www)

  @article{ , abstract = {The properties of π-functional materials are predominantly influenced by both their molecular structures and interactions between π-systems. Recent advancements have focused on modifying the geometry or topology of π-molecules from planar to nonplanar conformations to tailor molecular properties. However, the interactions among nonplanar π-molecules remain largely unexplored, likely due to the significant reduction in contact surfaces arising from their curved structures. Herein, we investigated the electro-optical properties and π-stacking behaviors of a series of bent perylenediimides ( B-PDI s) with gradual changes in bending angles, achieved by altering the lengths of linear alkyl chains connecting the two nitrogen positions of each PDI. Curvature-dependent self-assembly of these bent PDIs is observed, which is primarily driven by dipole-dipole interactions rather than dispersion forces. More importantly, fine-tuning intermolecular coupling through bending enables excited-state symmetry-breaking charge separation in [n]B-PDI s (n = 16, 12) in the crystalline solid state.}, archive = {J_ANGEW}, author = {Rui Wang and Baiyang Qian and Yuchuan Xu and Di Zhao and Qiqi Chen and Yifei Wei and Cankun Zhang and WanZhen Liang and Yun-Bao Jiang and Hui-Jun Zhang and Jianbin Lin}, doi = {10.1002/anie.202421871}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421871}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled bent perylenediimides}, volume = {64}, year = {2025}, }
• (2025). Bioinspired “Intermolecular pocket” in soft molecular crystal of porous organic cage exhibiting reversible guest recognition. ANGEW, 64(6), e202421753. (www)

  @article{ , abstract = {Porous Organic Cages (POCs) have gathered a lot of attention in sorts of fields. Previous studies often focused on the functionalization of their intrinsic porosity, while the utilization of the extrinsic porosity has been seldom reported. To date, the rational construction of functionalized extrinsic porosity in POCs is a serious challenge, which still relies on trial and error. Inspired by hydrophobic proteins, in the contribution, a POC (namely NKPOC-DS) is obtained with hydrophobic “intermolecular pocket” as extrinsic porosity constructed through the assembly of disulfide bonds with hydrophobic groups, facilitating strong supramolecular interactions as confirmed by Electrostatic Potential (ESP) maps and single-crystal X-ray diffraction analysis. Notably, NKPOC-DS exhibits a unique C 2 H 6 -selective “breathing behaviour” due to the presence of softness in its extrinsic porosity, which does not extend to other gases such as C 2 H 4 , CH 4 , CO 2 , N 2 , and H 2 . Such specific recognition of C 2 H 6 thus provides NKPOC-DS with the ability to preferentially adsorb C 2 H 6 from a C 2 H 6 /C 2 H 4 mixture. The innovative approach of biomimicry in the design of functional POCs provides new insights into manipulating the packing of cages, paving the way for potential applications in guest recognition and adsorption separations.}, archive = {J_ANGEW}, author = {Laiyu Zhang and Qiong Lei and Mao Yi and Zhiyuan Zhang and Xin Lian and Jian Xu and Shuo Zhang and Lin Li and Baiyan Li and Xian-He Bu}, doi = {10.1002/anie.202421753}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421753}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bioinspired “Intermolecular pocket” in soft molecular crystal of porous organic cage exhibiting reversible guest recognition}, volume = {64}, year = {2025}, }
• (2025). Stimuli-responsive DNA nanomachines for intracellular targeted electrochemiluminescence imaging in single cells. ANGEW, 64(6), e202421658. (www)

  @article{ , abstract = {Electrochemiluminescence (ECL) microscopy has emerged as a powerful technique for single-cell imaging owing to its unparalleled background-free imaging advantages. However, controlled intracellular ECL imaging remains challenging. Here, we developed a stimuli-responsive self-assembled DNA nanomachine that enables the ECL imaging of intracellular target biomolecules in single cells. The ECL nanoprobe consists of an ECL nanoemitter constructed from Ru(bpy) 3 2+ -doped metal–organic framework as the nanoreactor core, with a DNA polymer hydrogel (DNAgel) shell acting as the stimuli-gated layer. The outer functionalized DNAgel of the ECL nanoprobe was specifically designed to block ECL generation and to dissociate by ATP molecules, thereby enabling selective recovery of ECL emission capability. Such an engineered stimuli-responsive nanomachine successfully achieved the targeted ECL imaging of intracellular ATP distribution with spatial resolution. In addition, ECL imaging of various intracellular biomolecules should be generalizable by simply changing the switching DNA sequence of the probe. Our research provided a reliable strategy for ECL microscopy within cells, which will broaden the application of ECL in single-cell and single-molecule profiling.}, archive = {J_ANGEW}, author = {Binxiao Li and Yanwei Lu and Xuedong Huang and Neso Sojic and Dechen Jiang and Baohong Liu}, doi = {10.1002/anie.202421658}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stimuli-responsive DNA nanomachines for intracellular targeted electrochemiluminescence imaging in single cells}, volume = {64}, year = {2025}, }
• (2025). Arene ring expansion by ruthenium η6-arene complexes. ANGEW, 64(6), e202421608. (www)

  @article{ , abstract = {Transition metal π-arene complexes enable the dearomatization of benzene rings to access diversified unsaturated carbocycles through multistep synthetic procedures involving sequential addition of nucleophiles and electrophiles. This work details a single-step dearomatization process by reaction of Ru(η 6 -arene) complexes with enolates derived from α-halo or α-(tosyloxy)esters to directly transform π-coordinated arenes to ring-expanded cycloheptatrienes.}, archive = {J_ANGEW}, author = {William G. Whitehurst and Tim Schulte and Zikuan Wang and Felix Waldbach and Tobias Ritter}, doi = {10.1002/anie.202421608}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Arene ring expansion by ruthenium η6-arene complexes}, volume = {64}, year = {2025}, }
• (2025). Regio- and enantioselective rhodium-catalyzed allylic arylation of racemic allylic carbonates with arylboronic acids. ANGEW, 64(6), e202421596. (www)

  @article{ , abstract = {Rhodium-catalyzed regio- and enantioselective allylic arylation of racemic alkyl- and aryl- substituted allylic carbonates with arylboronic acids using commercially available BIBOP ligand is reported. This reaction proceeds at room temperature without base or other additive to deliver allylic arylation products in excellent yields, regio- and enantioselectivity (up to 95 % yield, >20 : 1 b/l, >99 % ee). Rh/BIBOP is disclosed as an efficient catalytic system for allylic substitution reaction.}, archive = {J_ANGEW}, author = {Hu-Chong Wang and Wen-Jie Shen and Shu-Li You}, doi = {10.1002/anie.202421596}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421596}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regio- and enantioselective rhodium-catalyzed allylic arylation of racemic allylic carbonates with arylboronic acids}, volume = {64}, year = {2025}, }
• (2025). Transmembrane delivery of an aryl azopyrazole photo-switchable ion transporter relay. ANGEW, 64(6), e202421580. (www)

  @article{ , abstract = {Stimuli-responsive synthetic ionophores allow for spatial and temporal control over ion transport, with promise for applications in targeted therapy. Relay transporters have emerged as a new class of ion transporters - these are anchored carriers that sit in both leaflets of the bilayer and mediate transport across the membrane by passing ions between them. The relays are themselves membrane impermeable, and so must be incorporated into the membrane during vesicle preparation. Here we show that relay transporters can be delivered to both sides of the membrane of vesicles using a synthetic flippase. By incorporating an aryl azopyrazole photo-switch into the movable arm of the relay transporters the ion transport activity can be very efficiently and reversibly switched between off and on states. This control is achieved by extension and contraction of their movable arms via photo-isomerization of the central aryl azopyrazole moiety, hence modulating the ability of the relays to pass ions across the membrane.}, archive = {J_ANGEW}, author = {Elin Grählert and Matthew J. Langton}, doi = {10.1002/anie.202421580}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421580}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transmembrane delivery of an aryl azopyrazole photo-switchable ion transporter relay}, volume = {64}, year = {2025}, }
• (2025). Photo-assisted bottom-up synthesis of orange phosphorus. ANGEW, 64(6), e202421571. (www)

  @article{ , abstract = {A tubular strand of phosphorus composed of vectorially aligned pentagons has been theoretically predicted as a new allotrope of phosphorus with a polar structure, expecting potential applications. However, it has not been successfully synthesized yet due to the difficulty of creating isolated strands to avoid interchain bonding. Here, such an allotrope named “orange phosphorus“ was successfully produced using a photo-assisted synthesis from an amorphous film of solution-processable Na 2 P 16 precursors. A green laser irradiation initiated the phase transition of precursors, inducing chemical reactions like topochemical polymerization and rearrangement, creating a 1D chain of orange phosphorus. 3D electron diffraction crystallography showed that the molecular structure of orange phosphorus consists of one-dimensional polar pentagonal-tubes made up of [P8]P2[ repeat units. Orange phosphorus demonstrates excellent piezoresistivity due to its high strain-sensitive 1D chain structure, showing strain-induced Raman shifts. Its gauge factor exceeds those of 2D materials such as black phosphorus and transition metal dichalcogenides. These findings indicate that orange phosphorus has great potential for use in strain sensor applications.}, archive = {J_ANGEW}, author = {Pengcheng Qiu and Jiameng Wang and Takahiro Kojima and Kenji Kazumi and Hiroyasu Sato and Naoki Komatsu and Kazuhiro Fukami and Hiroshi Sakaguchi}, doi = {10.1002/anie.202421571}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421571}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-assisted bottom-up synthesis of orange phosphorus}, volume = {64}, year = {2025}, }
• (2025). High-performance solution-processable organic light-emitting diode based on a narrowband near-ultraviolet emitter and a hot exciton strategy. ANGEW, 64(6), e202421520. (www)

  @article{ , abstract = {Achieving high efficiency narrowband near-ultraviolet (NUV) emitters in organic light emitting diode (OLED) is still a formidable challenge. Herein, a proof-of-concept hybridized local and charge transfer (HLCT) molecule, named ICz-BO, is prepared and characterized, in which both multiresonant (MR) skeletons are integrated via conjugation connection. A slightly distorted structure and weak intramolecular charge transfer (CT) interaction between two MR subunits lead to a high-lying reverse intersystem crossing (h-RISC) channel of T 6 → S 1 , also evidenced by both experimental and calculated results. Impressively, the ICz-BO emitter exhibits outstanding narrowband NUV emission at 404 nm with a full-width at half maximum of 28 nm in toluene solution. The solution processable OLED shows an excellent device performance with the recorded maximum external quantum efficiency of 12.01 %, concomitant with an extremely low y-axis Commission Internationale de l’Éclairage (CIE y ) value of 0.031. To the best of our knowledge, this is the highest efficiency reported for the HLCT-based NUV-OLEDs to date. This research proves that the MR skeleton plays a positive effect on the narrowband hot exciton emitter, which provides an alternative paradigm for developing high-efficiency NUV emitters.}, archive = {J_ANGEW}, author = {Kai Jiang and Xiang Chang and Jieqiong Zhu and Tian Zhu and Junting Yu and Yafei Wang and Youming Zhang and Dongge Ma and Weiguo Zhu}, doi = {10.1002/anie.202421520}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421520}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance solution-processable organic light-emitting diode based on a narrowband near-ultraviolet emitter and a hot exciton strategy}, volume = {64}, year = {2025}, }
• (2025). Asymmetric heck silylation of unactivated alkenes. ANGEW, 64(6), e202421500. (www)

  @article{ , abstract = {Heck silylation of unactivated alkenes is an efficient strategy for the synthesis of useful organosilicon compounds. However, extensive efforts have been dedicated to only achieving achiral molecules. Herein, a highly regio- and enantioselective cobalt-catalyzed Heck silylation of unactivated alkenes with hydrosilanes is reported for the first time, providing access to axially chiral alkenes in good to excellent yields with 87–98 % ee . Aryl and alkyl groups as well as quaternary carbon centers at the 4-position of vinylcyclohexane could be well tolerated, featuring good functional group tolerance. The gram-scale reaction proceeds smoothly under mild conditions even with 0.5 mol % catalyst loading. A possible mechanism has been proposed, in which enantioselectivity is controlled by alkene insertion. A templating strategy that enhances weak bond interaction is employed to control regioselectivity by modifying the substituents on the ligand and silane.}, archive = {J_ANGEW}, author = {Bingcheng Wang and Jiajin Zhao and Jiale Ying and Biao Cheng and Zhan Lu}, doi = {10.1002/anie.202421500}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421500}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric heck silylation of unactivated alkenes}, volume = {64}, year = {2025}, }
• (2025). Stereoselective synthesis of 1,n-dicarbonyl compounds through palladium-catalyzed ring Opening/Isomerization of densely substituted cyclopropanols. ANGEW, 64(6), e202421476. (www)

  @article{ , abstract = {We report a highly diastereoselective protocol for the synthesis of 1,4- and 1,5-dicarbonyl compounds from densely substituted cyclopropanols. The methodology involves a palladium-catalyzed ring opening reaction followed by a “metal-walk” and oxidation of a remote hydroxyl group. The methodology represents a new application of cyclopropanols as initiation sites for chain walking remote functionalization. Importantly, this approach provides a straightforward access to highly valuable succinaldehyde derivatives bearing vicinal quaternary and tertiary stereocenters as single diastereomers.}, archive = {J_ANGEW}, author = {Charlotte S. Teschers and Anthony Cohen and Ilan Marek}, doi = {10.1002/anie.202421476}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421476}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereoselective synthesis of 1,n-dicarbonyl compounds through palladium-catalyzed ring Opening/Isomerization of densely substituted cyclopropanols}, volume = {64}, year = {2025}, }
• (2025). Cleavage and reassembly of 1,3-dicarbonyls with enaminones to synthesize highly functionalized naphthols. ANGEW, 64(6), e202421374. (www)

  @article{ , abstract = {The cleavage of carbon-carbon bonds and their subsequent reassembly into highly functionalized and useful molecules in an atom-efficient manner has always been a central focus in the realm of organic synthesis. In this report, we describe the construction of highly functionalized naphthol esters via a tandem reassembly process, driven by Ullmann-type coupling of enaminones and 1,3-dicarbonyl compounds. Mechanistic investigations suggest the involvement of C(sp 2 )-C(sp 3 ) coupling, cyclization, two acyl migrations, aromatization, and additional transformations within this tandem sequence. This methodology offers several notable advantages, such as the use of inexpensive and easily accessible starting materials, the elimination of the need for expensive transition metal catalysis, simple operation in the atmosphere, exceptional compatibility with a wide range of substrates, and ease of conversion into drug scaffolds.}, archive = {J_ANGEW}, author = {Shuguang Zhou and Xin Liu and Tao Zhang and Teck-Peng Loh and Jie-Sheng Tian}, doi = {10.1002/anie.202421374}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421374}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cleavage and reassembly of 1,3-dicarbonyls with enaminones to synthesize highly functionalized naphthols}, volume = {64}, year = {2025}, }
• (2025). Flexible ZSM-5 zeolite membrane for high-performance helium separation. ANGEW, 64(6), e202421285. (www)

  @article{ , abstract = {Flexible zeolite membranes are promising for scalable and adaptable separation of critical gases such as helium; however, the synthesis of such membranes remains a significant challenge. In this study, we report the successful fabrication of crack-free ZSM-5 zeolite membranes on polytetrafluoroethylene (PTFE) supports using a seeded growth method. PTFE-supported membranes exhibit unprecedented helium permeance of over 6.7×10 −7 mol m −2 s −1 Pa −1 and high He/N 2 and He/CH 4 separation factors of 17 and 83 respectively, surpassing current state-of-the-art membranes. These flexible membranes maintain excellent separation performance even after bending and stretching. Furthermore, large-scale membranes demonstrate stable helium separation from multicomponent gas mixtures, showcasing their significant potential for practical helium extraction from natural gas.}, archive = {J_ANGEW}, author = {Yongyan Deng and Fuxin Qiu and Jiaxing Wu and Jialu Li and Ziyi Li and Qinglin Huang and Guangshan Zhu and Xiaoqin Zou}, doi = {10.1002/anie.202421285}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421285}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flexible ZSM-5 zeolite membrane for high-performance helium separation}, volume = {64}, year = {2025}, }
• (2025). Development and applications of an amide linchpin reagent. ANGEW, 64(6), e202421258. (www)

  @article{ , abstract = {Linchpin reagents are building blocks that can be chemoselectively functionalized to afford products with a common, useful functional group. In this work, we describe the development and validation of the first amide linchpin reagent and demonstrate its use as a doubly electrophilic building block for the synthesis of a variety of amides, including challenging classes. The linchpin reagent was first functionalized via rhodium-catalyzed electrophilic amination. Selected masked C -isocyanate products were then further derivatized with Grignard reagents to produce secondary amides, or tertiary amides if an alkylating agent was added subsequently. The success of this sequence relies on fully controlled reactivity at each electrophilic site, first exploiting the weak N−O bond and then, the ability to form the free isocyanate intermediate in situ. The overall transformation proceeds with high chemoselectivity, demonstrating the ability of this new linchpin reagent to form amides through atypical bond construction. Finally, the potential of this reagent as a more broadly applicable NCO linchpin is demonstrated by the formation of lactams and unsymmetrical ureas.}, archive = {J_ANGEW}, author = {Bhavana Uppalapati and Maxime A. Aubry and Qiang Wang and Dalia Abdelhamid and Monica A. Gill and André M. Beauchemin}, doi = {10.1002/anie.202421258}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421258}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development and applications of an amide linchpin reagent}, volume = {64}, year = {2025}, }
• (2025). Modular access to silicon-containing amino acids and peptides by cobalt catalysis. ANGEW, 64(6), e202421190. (www)

  @article{ , abstract = {A regioselective cobalt-catalyzed three-component silylamidation that rapidly and reliably incorporates dioxazolones and silylzinc pivalates into unconjugated alkenyl amides is disclosed. Notably, the unique power of this protocol is demonstrated by the possibility of achieving peptide ligation using peptide-containing dioxazolones or alkenyl amides as the coupling partners. Moreover, this approach is distinguished by its mild condition, synthetic simplicity, and ample scope, thus providing a new platform for modular access to silicon-containing amino acid derivatives and peptides.}, archive = {J_ANGEW}, author = {Jixin Wang and Zexu Chen and Kaixin Chen and Zhili Cui and Jie Li}, doi = {10.1002/anie.202421190}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular access to silicon-containing amino acids and peptides by cobalt catalysis}, volume = {64}, year = {2025}, }
• (2025). Electrodriven ATP synthesis via a reconstructed thylakoid membrane. ANGEW, 64(6), e202421120. (www)

  @article{ , abstract = {Nature produces ATP, the energy currency, by converting solar energy (photophosphorylation) and chemical energy (substrate-level phosphorylation and oxidative phosphorylation). Green electricity, as a significant and sustainable energy carrier, plays a crucial role in achieving a carbon-neutral society. In this work, we established and verified a novel electrodriven phosphorylation method. Spinach thylakoid membranes (TMs), enriched with ATPases, were isolated and constructed into planar TMs (pTMs) on a proton exchange membrane (PEM), effectively imparting the traditional PEM with the biological function of ATP regeneration. Following the optimization of TMs concentration and incubation time, the biological PEM was integrated into a two-compartment electrochemical cell, where ATP was successfully synthesized by ATPase of pTMs, triggered by the proton gradient potential generated during electrochemical water splitting. When a constant voltage of 3 V was applied to the electrochemical cells, ATP was synthesized at a rate of 3.16 μM min −1 μg Chl −1 , approximately twice the rate of ΔpH-driven ATP synthesis. This design offers substantial potential for green energy applications in in vitro biotransformation ( iv BT) systems.}, archive = {J_ANGEW}, author = {Lijing Chang and Huijuan Cui and Weisong Liu and Yi-Heng P. Job Zhang and Lingling Zhang}, doi = {10.1002/anie.202421120}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202421120}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrodriven ATP synthesis via a reconstructed thylakoid membrane}, volume = {64}, year = {2025}, }
• (2025). Visualization and quantification of single-base m6A methylation. ANGEW, 64(6), e202420977. (www)

  @article{ , abstract = {N 6 -methyladenosine (m 6 A) has emerged as the most prevalent form of RNA modification found across various RNA classes. The detection and quantification of m 6 A RNA modifications under various physiological conditions are crucial for elucidating disease mechanisms and identifying potential therapeutic targets. However, visualizing intracellular m 6 A modifications at single-base resolution remains a significant challenge. Existing methods based on high-throughput sequencing or in vitro assays are not suitable for in situ m 6 A RNA imaging. In this work, we introduce the TadA8.20-assisted N 6 -methyladenosine RNA imaging at single-base resolution (TARS) method for precise visualization and quantification of both A and m 6 A forms at specific RNA sites within single cells. Validation studies using TARS on MALAT1 lncRNA in HeLa cells and CCND1 mRNA in breast cancer cell lines demonstrated its high specificity and efficiency in mapping and quantifying m 6 A modifications at single-base resolution. TARS represents a novel tool that advances m 6 A RNA modification research by offering accurate and detailed insights into m 6 A modifications at the single-base level.}, archive = {J_ANGEW}, author = {Qiushuang Zhang and Yicong Dai and Xucong Teng and Jinghong Li}, doi = {10.1002/anie.202420977}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420977}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visualization and quantification of single-base m6A methylation}, volume = {64}, year = {2025}, }
• (2025). Linker installation in a Metal–Organic framework for enhanced quantitative redox species recognition. ANGEW, 64(6), e202420882. (www)

  @article{ , abstract = {Linker installation has proven to be an effective strategy for introducing diverse functional groups into metal–organic frameworks (MOFs). Reductants and oxidants are found in various environments, but their accumulation poses a danger due to their high reactivity, necessitating prompt monitoring instantly, particularly in natural environments and industrial processes. In this study, a series of redox-active dyes were successfully incorporated into a flexible Zr-based MOF, PCN-700, through linker installation strategy. Notably, both the reduction of PCN-700-Resazurin towards oxidants and oxidation of PCN-700-Amplex Red towards reductants result in the formation of PCN-700-Resorufin, which exhibit visible color changes and largely elevated luminescent intensities, giving rise to the quantitative recognition of reductants and oxidants. This work presents a straightforward approach to developing efficient luminescent sensors for the rapid qualitative and quantitative detection of reductants and oxidants, extending the sensing mechanism from common energy transfer to electron transfer and demonstrating the MOF's versability as a highly designable sensing material for target analytes.}, archive = {J_ANGEW}, author = {Zongsu Han and Kun-Yu Wang and Rong-Ran Liang and Yihao Yang and Jiatong Huo and Hong-Cai Zhou}, doi = {10.1002/anie.202420882}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420882}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Linker installation in a Metal–Organic framework for enhanced quantitative redox species recognition}, volume = {64}, year = {2025}, }
• (2025). Redox-neutral carboxylation of benzylic tertiary C−H bonds with carbon dioxide. ANGEW, 64(6), e202420852. (www)

  @article{ , abstract = {The direct catalytic carboxylation of benzylic tertiary C−H bonds with CO 2 for the synthesis of all-carbon quaternary carboxylic acids represents a significant challenge. Here, we present a redox-neutral approach to address this difficulty by leveraging the synergistic interplay between photocatalysis and cascade hydrogen abstraction cycles. Remarkably, this strategy eliminates the need for sacrificial electron donors, electron acceptors, or stoichiometric additives, offering enhanced atom economy and environmental sustainability. It is particular that the combination of α-amino alkyl radicals with sulfur radicals generated in situ from the decomposition of DMSO was employed to realize the abstraction of benzylic tertiary C−H bonds. Our method enables the direct synthesis of a diverse array of benzylic quaternary carboxylic acids with excellent functional group tolerance as well as the derivatization of bioactive molecules and the gram-scale synthesis of pharmaceuticals under mild reaction conditions.}, archive = {J_ANGEW}, author = {Jun-Li Li and Shan-Shan Zhang and Liang-Liang Jiang and Hao-Yuan Li and Can-Ming Zhu and Pan-Feng Yuan and Zhao Yang and Xiu-Long Yang and Jian-Ji Zhong and Qing-Yuan Meng}, doi = {10.1002/anie.202420852}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420852}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-neutral carboxylation of benzylic tertiary C−H bonds with carbon dioxide}, volume = {64}, year = {2025}, }
• (2025). Functionalization of covalent organic frameworks with cyclopentadienyl cobalt for C2H2/CO2 separation. ANGEW, 64(6), e202420801. (www)

  @article{ , abstract = {Emerging covalent organic frameworks (COFs) have received great attention for their unique features, but the limited building blocks restrict their structural diversity and performance exploration. Reticular chemistry provides guidance for the structural expansion and performance regulation of COFs. Herein, we constructed two novel two-dimensional (2D) COFs functionalized with cyclopentadienyl cobalt, denoted as UPC-COF-1 and UPC-COF-2, via [4+2] imine condensation with diamine building blocks of different length. Theoretical simulations combined with experimental results reveal that UPC-COF-1 with shorter building blocks, narrower pore sizes, and stronger host–guest interactions has better C 2 H 2 /CO 2 separation performance. In addition, UPC-COF-1 can maintain separation stability in the presence of water vapor and methane impurities. This work provides a new evidence for the performance regulation of isoreticular COFs with modular and tunable building blocks.}, archive = {J_ANGEW}, author = {Xiaokang Wang and Hongyan Liu and Meng Sun and Fei Gao and Xueying Feng and Mingming Xu and Weidong Fan and Daofeng Sun}, doi = {10.1002/anie.202420801}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420801}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Functionalization of covalent organic frameworks with cyclopentadienyl cobalt for C2H2/CO2 separation}, volume = {64}, year = {2025}, }
• (2025). Cascading water activation and interfacial lattice oxygen over nanocluster CuOx-modified MnO2 for electrocatalytic propylene oxidation. ANGEW, 64(6), e202420780. (www)

  @article{ , abstract = {Direct electrooxidation of propylene using water-oxidation intermediates represents a promising route for propylene glycol production. Unfortunately, this economic and environmentally friendly process suffers from low yield and poor Faradaic efficiency resulting from the mismatched oxidative capacity of reactive oxygen species and pronounced side reactions. Herein, we developed an earth-abundant metal-based nanocluster CuO x -modified MnO 2 catalyst for the efficient electrooxidation of propylene into propylene glycol, achieving a remarkable production rate of 63.0 g/m 2 /h and 95 % Faradaic efficiency at 1.3 V vs. Ag/AgCl. Mechanistic studies revealed that the oxygen vacancy-mediated water activation on CuO x -MnO 2 in synergy with the activated interfacial lattice oxygen drove the propylene oxidation to a novel *OOH pathway rather than the traditional *OH route. Additionally, the interfacial interactions intensified the propylene adsorption and polarization for its activation. This work offers new insights into the mechanism of electrocatalytic propylene oxidation and presents great opportunities for the synthesis of commercial chemicals based on earth-abundant metal catalysts and renewable electricity-driven route.}, archive = {J_ANGEW}, author = {Ming Cheng and Jintong Lan and Xiaoxian Sun and Fanyu Wang and Ailijiang Tuerdi and Falong Jia and Yanbing Guo and Xiao Liu}, doi = {10.1002/anie.202420780}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420780}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cascading water activation and interfacial lattice oxygen over nanocluster CuOx-modified MnO2 for electrocatalytic propylene oxidation}, volume = {64}, year = {2025}, }
• (2025). Chiroptical amplification of [7]-helicene nanographene by additional helical chirality. ANGEW, 64(6), e202420767. (www)

  @article{ , abstract = {Nanographenes have captivated scientific interest since the pioneering discovery of graphene. Recently, attention has shifted towards exploring chiral and nonplanar nanographenes, for their distinct optical, chiroptical, and electronic properties. Despite the growing acceptance of helicenes, the research on inducing helical chirality on π-extended derivatives to boost chiroptical properties remains unattended. In our study, we introduce a new π-extended [7]-helicene resulting from the condensation of diamines with 3,6-dibromophenanthrene-9,10-dione, complemented by two hexabenzocoronene arms in the periphery. Notably, the nanographene containing binaphtho-[1,4]diazocine, compared to the corresponding phenazine, exhibits a remarkable average 2.5, 5, and 10-fold enhancements in quantum yield, dissymmetry factor, and brightness, respectively, when measured in five different solvents. These improvements underscore the significance of the induced helical chirality by the antiaromatic binaphtho-[1,4]diazocine in influencing the chiroptical properties of the helical nanographene. Our research represents a significant stride toward unlocking the potential of π-extended helicenes and lays the groundwork for further exploration in designing and synthesizing new chiral nanomaterials.}, archive = {J_ANGEW}, author = {Sangram D. Dongre and Geethu Venugopal and Viksit Kumar and Ashok Badrinarayan Jadhav and Jatish Kumar and Sukumaran Santhosh Babu}, doi = {10.1002/anie.202420767}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420767}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiroptical amplification of [7]-helicene nanographene by additional helical chirality}, volume = {64}, year = {2025}, }
• (2025). In-situ formation of three-dimensional network intrinsic microporous ladder polymer membranes with ultra-high gas separation performance and anti-trade-off effect. ANGEW, 64(6), e202420742. (www)

  @article{ , abstract = {The global quest for clean energy and sustainable processes makes advanced membrane extremely attractive for energy-intensive industrial gas separations. Here, we disclose a series of ultra-high-performance gas separation membranes (PIM-3D-TB) from novel network polymers of intrinsic microporosity (PIM) that combine the advantages of solution processible PIM and small pore size distribution (PSD) of porous organic polymers (POP), which was synthesized by in situ copolymerization of triptycene-2,6-diamine as linear part and triptycene-2,6,13(14)-triamine (TTA) as crosslinker. The resulting PIM-3D-TB membranes demonstrated outstanding separation properties that outperformed the latest trade-off lines for H 2 /CH 4 and O 2 /N 2 . They also showed an anti-trade-off effect by simultaneously enhancing gas permeability and gas-pair selectivity with increasing TTA content. The TTA crosslinking node increased the microporosity, and, shifted the PSD from the ultramicropore (<7 Å) toward the more size sieving submicropore (<4 Å) region. The post-treated TTA-75 displayed an exceptional H 2 permeability of 8000 Barrer and H 2 /CH 4 selectivity of 208. These PIM-3D-TB membranes and their design protocol have unparalleled potential in the next generation of membranes for hydrogen purification and air separations.}, archive = {J_ANGEW}, author = {Luxin Sun and Wei Xu and Hongjun Zhang and Jiachen Chu and Mengtao Wang and Kai Song and Wenjie Wu and Jianxin Li and Yingge Wang and Ingo Pinnau and Xiaohua Ma}, doi = {10.1002/anie.202420742}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420742}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-situ formation of three-dimensional network intrinsic microporous ladder polymer membranes with ultra-high gas separation performance and anti-trade-off effect}, volume = {64}, year = {2025}, }
• (2025). Support-layer integrated zeolite membranes through in situ interfacial transformation of clay-based protomembranes. ANGEW, 64(6), e202420696. (www)

  @article{ , abstract = {Zeolite membranes are considered ideal inorganic membrane materials for separating mixtures with molecular-level differences. However, their complex preparation process with excessive synthesis solutions for traditional hydrothermal heating methods leads to various drawbacks. Here, we describe a membrane preparation strategy involving an in situ interfacial transformation of the protomembrane without solvents. Inexpensive clay powder forms the protomembrane, and the active ingredients subsequently migrate from the interior of this protomembrane to its surface and transform into a zeolite layer. Ultimately, the protomembrane is calcined to obtain the support-layer integrated zeolite membrane. Systematic research shows that clay not only serves as a raw material for the support but also provides active ingredients for the growth of zeolite crystals; thus, zeolite membranes with zeolite particles inserted into the support are formed. The zeolite membrane calcined at 800 °C possesses a p-xylene/o-xylene separation factor approaching 6263 with a permeation flux of 1.21×10 −7 mol ⋅  m −2 ⋅  s −1 ⋅  Pa −1 . This interfacial transformation method can be applied to other membranes and promote the development of membrane separation technology.}, archive = {J_ANGEW}, author = {Jun-Bin Zhang and Qiang Liu and Wen-Yan Pan and Jia-Wen Wu and Xingyang Li and Meng Pan and Zhi-Sheng Shi and Chun-Liang Du and Xue-Ling Wei}, doi = {10.1002/anie.202420696}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420696}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Support-layer integrated zeolite membranes through in situ interfacial transformation of clay-based protomembranes}, volume = {64}, year = {2025}, }
• (2025). Redox-tunable ring expansion enabled by a single-component electrophilic nitrogen atom synthon. ANGEW, 64(6), e202420664. (www)

  @article{ , abstract = {Controllable installation of a single nitrogen atom is central to many major goals in skeletal editing, with progress often gated by the availability of an appropriate N-atom source. Here we introduce a novel reagent, termed DNIBX, based on dibenzoazabicycloheptadiene (dbabh), which allows the electrophilic installation of dbabh to organic substrates. When indanone β-ketoesters are aminated by DNIBX, the resulting products undergo divergent ring expansions depending on the mode of activation, producing heterocycles in differing oxidation states under thermal and photochemical conditions. The mechanism of each transformation is discussed, and the different reactivity modes of the indanone-dbabh adducts are compared to other nitrogenous precursors.}, archive = {J_ANGEW}, author = {Patrick Q. Kelly and Nikki R. Keramati and Kate R. Kaplin and Tessa Lynch-Colameta and James P. Phelan and Mark D. Levin}, doi = {10.1002/anie.202420664}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-tunable ring expansion enabled by a single-component electrophilic nitrogen atom synthon}, volume = {64}, year = {2025}, }
• (2025). Benzylic C(sp3)−H phosphonylation via dual photo and copper catalysis. ANGEW, 64(6), e202420613. (www)

  @article{ , abstract = {Alkyl phosphonates are important motifs in medicinal chemistry, yet their efficient synthesis by direct C(sp 3 )−H functionalization remains a challenge. Here, we report straightforward access to benzylic phosphonates by direct C(sp 3 )−H functionalization in a cross-dehydrogenative-coupling reaction between non-specialized alkylarenes and unfunctionalized phosphites. Notably, the C−H substrates are used as the limiting reagents. The scope of benzylic C−H substrates is broad, and the mild reaction conditions allow for good functional group tolerance. Mechanistic studies indicate that the reaction proceeds via a radical pathway rather than the cationic pathway followed for specialized benzylic C−H substrates in previous methods.}, archive = {J_ANGEW}, author = {Heng-Hui Li and Yuwen Liu and Søren Kramer}, doi = {10.1002/anie.202420613}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420613}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Benzylic C(sp3)−H phosphonylation via dual photo and copper catalysis}, volume = {64}, year = {2025}, }
• (2025). Neuromorphic nanofluidic sense digitalization. ANGEW, 64(6), e202420602. (www)

  @article{ , abstract = {Nanofluidic memristors have recently been reshaped into artificial synapses capable of mimicking many fundamental neurosynaptic patterns, while sense digitalization has been increasingly explored to link the neuromorphic devices with external equipment. By inspiration of dopaminergic nerve, here a nanofluidic nerve with sense digitalization is devised by engineering a dopamine (DA)-specific nanofluidic synapse as mediated by PC-12 cells to manage the robotic arm. Different from previous neuromorphic perception of DA via redox reaction, the aptamer-based perception here is based on biological DA recognition by its receptor as indicated by the ionic signals. Various neurosynaptic patterns are emulated with DA-dependent plasticity, based on which the digital representation of DA perception is used to control the robotic arm.}, archive = {J_ANGEW}, author = {Zu-Ming Duan and Yi-Tong Xu and Zheng Li and Jian-Xiang Pang and Jing-Juan Xu and Wei-Wei Zhao}, doi = {10.1002/anie.202420602}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Neuromorphic nanofluidic sense digitalization}, volume = {64}, year = {2025}, }
• (2025). Combination of ambient and high-temperature beryllium nitride motifs in W2Be4N5 and W4Be8N9. ANGEW, 64(6), e202420583. (www)

  @article{ , abstract = {Compounds of transition metals and beryllium have a wide range of applications, from everyday tools to high tech applications. Remarkably, no single ternary beryllium nitride with a transition metal is known. Here, we report on the synthesis and properties of the first transition metal nitridoberyllates, namely W 2 Be 4 N 5 and W 4 Be 8 N 9 . Both compounds were synthesized in a high-temperature high-pressure approach from Be 3 N 2 and W, using azide generated N 2 as an oxidizing agent. The crystal structures, consisting of alternating layers of WN 6 trigonal prisms and BeN 4 tetrahedra, were elucidated by single-crystal X-ray diffraction (sc-XRD). The separating nitridoberyllate layers show either ambient temperature (α-Be 3 N 2 type) or high temperature (β-Be 3 N 2 type) motifs. W 2 Be 4 N 5 was further corroborated by infrared (IR), nuclear magnetic resonance (NMR) and UV/Vis spectroscopy and vibrating sample magnetometry (VSM) measurements. The latter revealed a mixed valence with an intermediate oxidation state of 3.5 for the W atoms. Both, the synthesis of the first transition metal nitridoberyllates and the synthesis approach using elemental W pave the way to a new field of nitride chemistry.}, archive = {J_ANGEW}, author = {Georg Krach and Dominik Werhahn and Kristian Witthaut and Dirk Johrendt and Wolfgang Schnick}, doi = {10.1002/anie.202420583}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420583}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Combination of ambient and high-temperature beryllium nitride motifs in W2Be4N5 and W4Be8N9}, volume = {64}, year = {2025}, }
• (2025). Computer-aided development of new nonlinear optical materials. ANGEW, 64(6), e202420526. (www)

  @article{ , abstract = {Exploring new nonlinear optical (NLO) materials is an urgent need for advanced photoelectric technologies. However, the discovery of new materials with targeted properties is time-consuming, and involves various challenges by the traditional trial-and-error experiments. Recently, the theoretical prediction-guided structural design has been demonstrated as a feasible way for efficiently developing new NLO materials, and a large number of NLO candidates with excellent optical properties have been explored. To promote the development of high-performance NLO materials, this review provides a summary on the exploration of new NLO materials aided by computer, with a particular emphasis on the state-of-the-art research advances that including crystal structure predictions, optical & thermal property calculations, high-throughput screening of NLO materials with or without machine learning; and the progress achieved in the computer-assisted design and development of new deep ultraviolet (DUV), ultraviolet (UV), infrared (IR) NLO materials in various material systems: oxide, chalcogenide, nitride, and halide. Finally, the opportunities and forthcoming challenges in the fascinating field are discussed.}, archive = {J_ANGEW}, author = {Hongshan Wang and Miriding Mutailipu and Zhihua Yang and Shilie Pan and Junjie Li}, doi = {10.1002/anie.202420526}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420526}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Computer-aided development of new nonlinear optical materials}, volume = {64}, year = {2025}, }
• (2025). Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of alzheimer's disease. ANGEW, 64(6), e202420510. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and behavioral and psychological symptoms of dementia (BPSD). Given that cholinergic neurons are predominantly affected in AD, current treatments primarily aim to enhance cholinergic neurotransmission. However, imbalances in other neurotransmitters, such as γ-aminobutyric acid (GABA), also contribute to AD symptomatology. In the presented research, using a combination of crystallography and computational methods we developed compound 6 as a dual modulator of GABAergic and cholinergic neurotransmission systems. Compound 6 demonstrated inhibition of BuChE (IC 50 =0.21 μM) and GABA transporter 1 (IC 50 =10.96 μM) and 3 (IC 50 =7.76 μM), along with a favorable drug-likeness profile. Subsequent in vivo studies revealed the effectiveness of 6 in enhancing memory retention and alleviating anxiety and depression symptoms in animal models, while also proving safe and bioavailable for oral administration. The innovative multi-target-directed ligand 6 offers a new approach to treating cognitive deficits and BPSD in AD.}, archive = {J_ANGEW}, author = {Dawid Panek and Anna Pasieka and Jakub Jończyk and Milena Gawlińska and Paula Zaręba and Agata Siwek and Małgorzata Wolak and Barbara Mordyl and Monika Głuch-Lutwin and Gniewomir Latacz and Xavier Brazzolotto and Fabien Chantegreil and Florian Nachon and Jana Zdarova Karasova and Jaroslav Pejchal and Martin Mzik and Vit Sestak and Lukas Prchal and Jitka Odvarkova and Ondrej Soukup and Jan Korabecny and Ales Sorf and Marie Hamsikova and Lucie Zemanova and Lubica Muckova and Nela Vánova and Pola Dryja and Kinga Sałat and Georg Höfner and Klaus Wanner and Anna Więckowska and Barbara Malawska}, doi = {10.1002/anie.202420510}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420510}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of alzheimer's disease}, volume = {64}, year = {2025}, }
• (2025). Convergent total synthesis of kalmanol. ANGEW, 64(6), e202420507. (www)

  @article{ , abstract = {Kalmanol ( 1 ) is the first isolated kalmane-type grayanoid featuring a highly oxidized 5/8/5/5 tetracyclic carbon skeleton and 9 contiguous stereocenters. We have accomplished the efficient and asymmetric total synthesis of 1 in 16 steps from known compounds (20 steps from commercially available starting materials) by a modular synthetic strategy. A tetracyclic intermediate was prepared in a convergent manner through a Grignard reaction and a subsequent ring-closing metathesis reaction of two enantiomerically enriched fragments. The polyhydroxy groups were introduced by late-stage stereo- and regioselective oxidations.}, archive = {J_ANGEW}, author = {Rong Zhao and Xiaolong Zhao and Ming Yang}, doi = {10.1002/anie.202420507}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420507}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Convergent total synthesis of kalmanol}, volume = {64}, year = {2025}, }
• (2025). A c156 molecular nanocarbon: Planar/Rippled nanosheets hybridization. ANGEW, 64(6), e202420419. (www)

  @article{ , abstract = {A novel hybrid nanocarbon consisting of one rippled and two planar nanosheets has been synthesized and characterized. Two meso pairs of [5]helicenes are formed along the long molecular axis of the hybrid to connect rippled and planar subunits, leading to a stable conformation. It is shown that the hybrid possesses the individual electronic properties of the rippled and planar subunits. Compared to the rippled subunit, such hybrid has a better geometric match to C 60 and complexes with C 60 in a 1 : 1 stoichiometry, with the association constant on the order of 10 5 M −1 . The hybrid displays unusual anti -Kasha fluorescence emission. The transient absorption spectroscopy revealed that the singlet fission (SF) from higher level singlet excited states (S n ) is operative in the film of the hybrid.}, archive = {J_ANGEW}, author = {Ruihua Fu and Xingyu Chen and Fei Qiu and Xinyue Liu and Jianlong Xia and Lei Zhang}, doi = {10.1002/anie.202420419}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420419}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A c156 molecular nanocarbon: Planar/Rippled nanosheets hybridization}, volume = {64}, year = {2025}, }
• (2025). Stereoselective P(III)-glycosylation for the preparation of phosphinated sugars. ANGEW, 64(6), e202420355. (www)

  @article{ , abstract = {Most of the reported work focus on the development of O -, N -, C - and S -glycosylation methods. However, no study explores P(III)-glycosylation reaction. Herein we describe a convenient protocol to realize P(III)-glycosylation process. A simple β -phosphino ester is adopted as P(III)-transfer reagent for this new type of glycosylation via a nucleophilic substitution and release strategy. Diverse phosphine units are introduced to the anomeric center of various sugars efficiently and with excellent stereoselectivity. The value of this method is showcased by the prepared P(III)-sugars as novel linkers in bioactive molecule conjugation, new chiral ligands in metal-catalyzed asymmetric allylic substitutions and organocatalysts. Preliminary mechanistic studies corroborated the designed P(III)-transfer process.}, archive = {J_ANGEW}, author = {Xuan Zhang and Xian-Xiao Chen and Zi-Han Li and Guo-Qiang Lin and Zhi-Tao He}, doi = {10.1002/anie.202420355}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420355}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereoselective P(III)-glycosylation for the preparation of phosphinated sugars}, volume = {64}, year = {2025}, }
• (2025). Chiral metal-free anti-perovskite with strong chiroptical nonlinearity. ANGEW, 64(6), e202420249. (www)

  @article{ , abstract = {The nonlinear chiroptical properties of chiral metal halide perovskite has attracted substantial attention in recent years. In order to overcome the inherent limitations of metal halide, such as high costs, potential toxicity, challenges with recycling, especially the limited laser-induced damage threshold (LDT), we have successfully constructed the first chiral metal-free anti-perovskite, with the aim of utilizing it in second harmonic generation-circular dichroism (SHG-CD). Moreover, the anti-perovskite composed entirely of small organic ions typically display a more extensive transparent window, which could contribute a high LDT. Herein two chiral metal-free anti-perovskites, R / S -MCN [( R / S -MBA) 6 Cl(NH 4 Cl 6 )] were constructed, and exhibit strong second-harmonic generation response from 800 to 980 nm. The second-order nonlinear optical coefficient of the chiral metal-free anti-perovskite reaches 0.89 pm/V, which is higher than that of commercial Y-cut quartz. Most importantly, both R - and S -MCN exhibit a large nonlinear optical activity with a high SHG dissymmetry factor ( g SHG-CD ) of 0.60 and a high laser-induced damage threshold of 71 mJ/cm 2 , which is higher than that of most reported chiral perovskites. Our findings indicate that chiral metal-free anti-perovskite have the potential to be a valuable addition to the development of next-generation nonlinear chiroptical devices.}, archive = {J_ANGEW}, author = {Zhaoyu Wang and Xin Qiu and Hebin Wang and Wenkai Zhao and Sehrish Gull and Haolin Lu and Zechen Hao and Bing Sun and Xin Zeng and Xinfeng Liu and Hao-Li Zhang and Yongsheng Chen and Tingchao He and Guankui Long}, doi = {10.1002/anie.202420249}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420249}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral metal-free anti-perovskite with strong chiroptical nonlinearity}, volume = {64}, year = {2025}, }
• (2025). Control of bilayer transport through a photoswitchable membrane-stiffening agent. ANGEW, 64(6), e202420232. (www)

  @article{ , abstract = {The mobility of proteins in the bilayer membrane is affected by (local) changes in lipid environment, which is important to their biological functioning. Artificial molecular systems that—to some extent—imitate tasks of membrane-embedded proteins are increasingly developed, however, they are usually controlled through responsive units in their core structure. Here we present an alternative approach based on an amphiphilic stiff-stilbene derivative that enables control of membrane fluidity by light. The fluidity increase upon E -to- Z isomerization is shown to enhance the activity of known synthetic anion transporters as a result of a higher mobility. The photoisomerization process is studied by UV/Vis and 1 H NMR spectroscopy in solution and in POPC vesicles, where the light-induced changes in fluidity and hence, activity of anion transporters, are monitored by fluorescence spectroscopy. Dynamic light-scattering (DLS) and cryo-EM studies show that vesicle integrity is not impaired by photoswitching. Our work introduces a versatile approach to control solute transport by carrier molecules. Moreover, the photocontrol over membrane fluidity and, with that, mobility could eventually be used for directed motion, which we expect to be key in achieving active transport in the future.}, archive = {J_ANGEW}, author = {Jasper E. Bos and Nol Duindam and Thomas J. F. Kock and Maxime A. Siegler and Sander J. Wezenberg}, doi = {10.1002/anie.202420232}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420232}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Control of bilayer transport through a photoswitchable membrane-stiffening agent}, volume = {64}, year = {2025}, }
• (2025). Manipulating p-π resonance through methoxy group engineering in covalent organic frameworks for an efficient photocatalytic hydrogen evolution. ANGEW, 64(6), e202420217. (www)

  @article{ , abstract = {Kinetic factors frequently emerge as the primary constraints in photocatalysis, exerting a critical influence on the efficacy of polymeric photocatalysts. The diverse conjugation systems within covalent organic frameworks (COFs) can significantly impact photon absorption, energy level structures, charge separation and migration kinetics. Consequently, these limitations often manifest as unsatisfactory kinetic behavior, which adversely affects the photocatalytic activity of COFs. To address these challenges, we propose a methoxy (−OMe) molecular engineering strategy designed to enhance charge carrier kinetics and mitigate mass transfer resistance. Through strategic modulation of the position and quantity of −OMe units, we can effectively manipulate the p-π conjugation, thereby enhancing charge separation and migration. Moreover, COFs enriched with −OMe moieties exhibit enhanced mass transfer dynamics due to the hydrophilic nature of methoxy groups, which facilitate the diffusion of reactants and products within the porous structure. This approach is hypothesized to drive an efficient photocatalytic hydrogen evolution reaction.}, archive = {J_ANGEW}, author = {Zhipeng Luo and Shipeng Zhu and Huanglan Xue and Wanxiang Yang and Fengtao Zhang and Fei Xu and Wei Lin and Hongqiang Wang and Xiong Chen}, doi = {10.1002/anie.202420217}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420217}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating p-π resonance through methoxy group engineering in covalent organic frameworks for an efficient photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). High-throughput combinatorial metal complex synthesis. ANGEW, 64(6), e202420204. (www)

  @article{ , abstract = {High-throughput combinatorial metal complex synthesis has emerged as a powerful tool for rapidly generating and screening diverse libraries of metal complexes, enabling accelerated discovery in fields such as catalysis, medicinal chemistry, and materials science. By systematically combining building blocks under mild and efficient conditions, researchers can explore broad chemical spaces, increasing the likelihood of identifying complexes with desired properties. This method streamlines hit identification and optimisation, especially when integrated with high-throughput screening and data-driven approaches like machine learning. Despite challenges such as scalability and purity control, recent advancements in automation and predictive modelling are enhancing the efficiency of combinatorial synthesis, opening new avenues for the development of metal-based catalysts, therapeutic agents, and functional materials.}, archive = {J_ANGEW}, author = {A. Welsh and D. Husbands and A. Frei}, doi = {10.1002/anie.202420204}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420204}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-throughput combinatorial metal complex synthesis}, volume = {64}, year = {2025}, }
• (2025). Remote on-paper electrochemiluminescence-based high-safety and multilevel information encryption. ANGEW, 64(6), e202420184. (www)

  @article{ , abstract = {The escalating needs in information protection underscore the urgency of developing advanced encryption strategies. Herein we report a novel chemical approach that enables information encryption by on-paper electrochemiluminescence (ECL). Dendritic porous silica nanospheres modified with polyetherimide and bovine serum albumin were prepared as the chemical ink to write the secret message on a paper. Attaching the paper to an electrode, immersing it in a solution containing tris(2,2′-bipyridyl)ruthenium (Ru(bpy) 3 2+ ) and then applying a suitable voltage, a remote “catalytic route” electrochemical reaction produces ECL that functions as the key to decrypt and visualize the message by imaging. In addition, proteins can be also used as the biological ink to write the secret message, which is then decrypted by a combined use of immunochemistry and ECL imaging as two keys. We believe the ECL-based strategy holds great promise in high-safety and multilevel information encryption, as it is protected not only by encoding, like conventional invisible inks, but also by the unique ECL decoding approach.}, archive = {J_ANGEW}, author = {Wenxuan Fu and Min Qi and Yidan Rong and Chukai Lin and Weiliang Guo and Bin Su}, doi = {10.1002/anie.202420184}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420184}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote on-paper electrochemiluminescence-based high-safety and multilevel information encryption}, volume = {64}, year = {2025}, }
• (2025). Scrolled Poly(L-lactic acid) single crystals via chain end-induced symmetry-breaking. ANGEW, 64(6), e202420137. (www)

  @article{ , abstract = {Single crystals that do not obey translational symmetry have been reported in various material systems. In polymers, twisted crystals are typically formed in banded spherulites, while a class of non-flat polymer single crystals (PSCs) has been observed. Herein, we report the formation of scrolled single crystals of biodegradable polymer poly( L -lactic acid) (PLLA). While classical 2-dimensional single crystals formed in solution-crystallized PLLA are flat, we show that PLLA crystals bend into scrolls when the polymer molecular weight is low. The formation of these unique scrolled PLLA single crystals depends on polymer chain ends and the polymer molecular weight. This work, therefore, demonstrates a new mechanism to break translational symmetry in PSC growth.}, archive = {J_ANGEW}, author = {Shichen Yu and Seyong Kim and Kingsley O. Ojima and Bin Zhao and Christopher Y. Li}, doi = {10.1002/anie.202420137}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202420137}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scrolled Poly(L-lactic acid) single crystals via chain end-induced symmetry-breaking}, volume = {64}, year = {2025}, }
• (2025). Heavy pentaisopropylcyclopentadienyltriylenes and their heterobimetallic complexes. ANGEW, 64(6), e202419688. (www)

  @article{ , abstract = {A series of triylenes of the heavy group 13 elements gallium, indium and thallium, carrying the pentaisopropylcyclopentadienyl ligand is reported. The compounds were characterized in solution and in the solid-state and their donor ligand properties in heterobimetallic complexes were investigated, whereby a series of tungsten carbonyl complexes was isolated. Furthermore, a new synthetic route towards a previously described lithium-aluminum heterobimetallic dimetallocene is reported, which also enabled the isolation of a heterobimetallic polydecker of lithium and gallium.}, archive = {J_ANGEW}, author = {Inga-Alexandra Bischoff and Bernd Morgenstern and Michael Zimmer and André Schäfer}, doi = {10.1002/anie.202419688}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202419688}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heavy pentaisopropylcyclopentadienyltriylenes and their heterobimetallic complexes}, volume = {64}, year = {2025}, }
• (2025). Electrosynthesis of mussel-inspired adhesive polymers as a novel class of transient enzyme stabilizers. ANGEW, 64(6), e202419684. (www)

  @article{ , abstract = {Multifunctional ortho-quinones are required for the formation of thiol-catechol-connectivities (TCC) but can be delicate to handle. We present the electrochemical oxidation of the dipeptide DiDOPA, achieving up to 92 % conversion efficiency of the catechols to ortho-quinones. Graphite and stainless steel could be employed as cost-efficient electrodes. The electrochemical activation yields quinone-solutions, which are free of undesired reactive compounds and eliminates the challenging step of isolating the reactive quinones. The DiDOPA quinones were employed in polyaddition reactions with multi-thiols, forming oligomers that functioned as transient enzyme stabilizers (TES). These TCC-TES-additives improved the thermal stability and the activity of tyrosinase in heat stress assays.}, archive = {J_ANGEW}, author = {Tilmann J. Neubert and Maximilian M. Hielscher and Keven Walter and Carolin M. Schröter and Marion Stage and Ruben R. Rosencrantz and Felix Panis and Annette Rompel and Kannan Balasubramanian and Siegfried R. Waldvogel and Hans G. Börner}, doi = {10.1002/anie.202419684}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202419684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrosynthesis of mussel-inspired adhesive polymers as a novel class of transient enzyme stabilizers}, volume = {64}, year = {2025}, }
• (2025). Unveiling the influence of oxygen on drug release dynamics in semipermeable polymersomes. ANGEW, 64(6), e202419087. (www)

  @article{ , abstract = {Semipermeable polymersomes, a class of polymeric vesicles that allow molecular passage across their membranes, offer significant potential for controlled drug delivery. These vesicles can be designed for inherent or selective permeability through the choice of suitable copolymers or the incorporation of protein nanopores, respectively. In this study, we explore a novel approach using oxygen-producing enzymatic reactions within biodegradable poly(ethylene glycol)-poly(caprolactone-gradient-trimethylene carbonate) (PEG-p(CL-g-TMC)) polymersomes to modulate drug release. These polymersomes were found to enhance the release of hydrophobic drugs while retaining hydrophilic drugs. The enzymatic generation of oxygen within the polymersomes increased membrane hydrophobicity, influencing drug release kinetics. The findings highlight the importance of understanding drug release kinetics in designing effective drug delivery systems, as the release rate and mechanism critically impact therapeutic efficacy and patient outcomes.}, archive = {J_ANGEW}, author = {Matteo Tollemeto and Pascal L. W. Welzen and Lasse H E. Thamdrup and Yudong Li and Tania Patiño Padial and Anja Boisen and Jan van Hest}, doi = {10.1002/anie.202419087}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202419087}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the influence of oxygen on drug release dynamics in semipermeable polymersomes}, volume = {64}, year = {2025}, }
• (2025). Photochemical deracemization of N-carboxyanhydrides en route to chiral α-amino acid derivatives. ANGEW, 64(6), e202418873. (www)

  @article{ , abstract = {Readily accessible, racemic N -carboxyanhydrides (NCAs) of α-amino acids underwent a deracemization reaction upon irradiation at λ=366 nm in the presence of a chiral benzophenone catalyst. The enantioenriched NCAs (up to 98 % ee ) serve as activated α-amino acid surrogates and, due to their instability, they were directly converted into consecutive products. N -Protected α-amino acid esters were obtained after reaction with MeOH and N -benzoylation (14 examples, 70 %- quant ., 82–96 % ee ). Other consecutive reactions included amide (ten examples, 65 %- quant ., 90–98 % ee ) and peptide (three examples, 75–89 %, d. r.=97/3 to 94/6) bond formation. Limitations of the method relate for some NCAs to issues with solubility, photooxidation, and high configurational lability.}, archive = {J_ANGEW}, author = {Maximilian Iglhaut and Philip Freund and Thorsten Bach}, doi = {10.1002/anie.202418873}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418873}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photochemical deracemization of N-carboxyanhydrides en route to chiral α-amino acid derivatives}, volume = {64}, year = {2025}, }
• (2025). A hypothesis on the function of high-valent fe in NiFe (Hydr)oxide in the oxygen-evolution reaction. ANGEW, 64(6), e202418798. (www)

  @article{ , abstract = {This study investigated the dynamic changes in NiFe (hydr)oxide and identified the role of high-valent Fe in the oxygen-evolution reaction (OER) within alkaline media via in situ techniques. Several high-valent Fe ions were found to remain considerably stable in the absence of potential in NiFe (hydr)oxide, even 96 hours after the OER. For Ni 2+ hydroxide treated with 57 Fe ions, where Fe sites are introduced onto the surface of Ni 2+ hydroxide, no Fe 4+ species were detected at the rate-determining step (RDS). The findings of this study suggested that the oxidation of bulk Fe ions, similar to Ni ions, to high valent forms, is charge accumulation without a direct role in OER; these results offered a novel perspective on manipulating Fe states to optimize OER efficacy. The prevailing hypothesis suggested that trace amounts of high-valent Fe ions, notably those on the surface, directly participate in OER.}, archive = {J_ANGEW}, author = {Nader Akbari and Jafar Hussain Shah and Cejun Hu and Subhajit Nandy and Pavlo Aleshkevych and Rile Ge and Sumbal Farid and Changchang Dong and Liang Zhang and Keun Hwa Chae and Wei Xie and Taifeng Liu and Junhu Wang and Mohammad Mahdi Najafpour}, doi = {10.1002/anie.202418798}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418798}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A hypothesis on the function of high-valent fe in NiFe (Hydr)oxide in the oxygen-evolution reaction}, volume = {64}, year = {2025}, }
• (2025). An advanced 3D crosslinked conductive binder for silicon anodes: Leveraging glycerol chemistry for superior lithium-ion battery performance. ANGEW, 64(6), e202418794. (www)

  @article{ , abstract = {Silicon (Si) anodes hold great promise for high-capacity lithium-ion batteries (LIBs), yet their practical application is hindered by severe volume expansion and mechanical degradation. To tackle these challenges, we present an innovative 3D crosslinked conductive polyoxadiazole (POD) binder engineered with glycerol (GL) to form a robust network of covalent and hydrogen bonds. This unique chemical architecture not only enhances adhesion and mechanical resilience to effectively dissipate the stresses induced by Si's volumetric changes but also constructs a robust conductive framework to facilitate electron transfer. The dynamic interplay between strong covalent and flexible hydrogen bonds in the POD-c-GL binder enables superior structural integrity and stable solid-electrolyte interphase (SEI) during cycling. The Si@POD-c-GL anode exhibits remarkable electrochemical performance, including a high initial Coulombic efficiency, impressive rate capability, and outstanding cycling stability. This work highlights the potential of harnessing in situ crosslinking chemistry to develop advanced binders, paving the way for the next generation of high-performance Si anodes in LIBs.}, archive = {J_ANGEW}, author = {Yuanyuan Yu and Chen Yang and Jiadeng Zhu and Baolong Xue and Junhua Zhang and Mengjin Jiang}, doi = {10.1002/anie.202418794}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418794}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An advanced 3D crosslinked conductive binder for silicon anodes: Leveraging glycerol chemistry for superior lithium-ion battery performance}, volume = {64}, year = {2025}, }
• (2025). Palladium single atom-supported covalent organic frameworks for aqueous-phase hydrogenative hydrogenolysis of aromatic aldehydes via hydrogen heterolysis. ANGEW, 64(6), e202418790. (www)

  @article{ , abstract = {Developing a method for the tandem hydrogenative hydrogenolysis of bio-based furfuryl aldehydes to methylfurans is crucial for synthesizing sustainable biofuels and chemicals; however, it poses a challenge due to the easy hydrogenation of the C=C bond and difficult cleavage of the C−O bond. Herein, a palladium (Pd) single-atom-supported covalent organic framework was fabricated and showed a unique 2,5-dimethylfuran yield of up to 98.2 % when reacted with 5-methyl furfuryl aldehyde in an unprecedented water solvent at 30 °C. Furthermore, it exhibited excellent catalytic universality while converting various furfuryl-, benzyl-, and heterocyclic aldehydes at room temperature. The analysis of the catalytic mechanism confirmed that H 2 was heterolytically activated on the Pd−N pair and triggered the keto-enol tautomerism of the covalent organic frameworks (COFs) host, resulting in H − −Pd⋅⋅⋅O−H + sites. These sites served as novel asymmetric hydrogenation sites for the C=O group and hydrogenolysis sites for the C−OH group through a scarce SN 2 mechanism. This study demonstrated remarkable bifunctional catalysis through the H 2 -induced keto-enol tautomerism of COF catalysts for the atypical preparation of methyl aromatics in a water solvent at room temperature.}, archive = {J_ANGEW}, author = {Zhihao Ouyang and Guan Sheng and Yao Zhong and Jun Wang and Jianxin Cai and Shuguang Deng and Qiang Deng}, doi = {10.1002/anie.202418790}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Palladium single atom-supported covalent organic frameworks for aqueous-phase hydrogenative hydrogenolysis of aromatic aldehydes via hydrogen heterolysis}, volume = {64}, year = {2025}, }
• (2025). Improving the blue color purity of tetradentate Pt(II) complexes with the assistance of F⋅⋅⋅H interaction towards high-performance blue phosphorescent OLEDs with EQE over 33 %. ANGEW, 64(6), e202418770. (www)

  @article{ , abstract = {Among the various challenges in the field of organic light-emitting diodes (OLEDs), simultaneously achieving high efficiency, a long lifespan, and a narrow full-width at half maximum (FWHM) in blue OLEDs remains a significant hurdle. Herein, we demonstrate a strategy to improve the color purity of tetradentate Pt(II) complexes with the assistance of ⋅⋅⋅H interaction by incorporating trifluoromethyl (−CF 3 ) groups into the well-known blue tetradentate Pt(II) phosphorescent complex. The results show that the different substitution positions of −CF 3 have significantly varying effects on the FWHM values of the complexes; specifically, introducing −CF 3 on the benzene ring of carbazole effectively reduces the FWHM, while introducing it on the benzene ring linked to the carbene unit has a minimal impact. When utilized in a mixed host system of SiCzCz/SiTrzCz2, the OLEDs with these new complexes as emitters demonstrated maximum external quantum efficiencies (EQEs) of 27.1 %, 33.8 %, and 27.6 % for PtON-CF 3 -1 , PtON-CF 3 -2 , and PtON-2CF 3 , respectively, with excellent color purity (CIEy≈0.14 for the PtON-CF 3 -2 based device). Notably, the device based on PtON-CF 3 -2 matched the stability of the benchmark PtON-TBBI complex.This work offers an important guideline for the design of high efficient Pt(II) phosphorescent complexes with good blue color purity.}, archive = {J_ANGEW}, author = {Jianing Zhu and Manli Huang and Youming Zhang and Zhanxiang Chen and Yijia Deng and Hongyang Zhang and Xinzhong Wang and Chuluo Yang}, doi = {10.1002/anie.202418770}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418770}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving the blue color purity of tetradentate Pt(II) complexes with the assistance of F⋅⋅⋅H interaction towards high-performance blue phosphorescent OLEDs with EQE over 33 %}, volume = {64}, year = {2025}, }
• (2025). Inverse vulcanization of aziridines: Enhancing polysulfides for superior mechanical strength and adhesive performance. ANGEW, 64(6), e202418764. (www)

  @article{ , abstract = {This study introduces a novel approach to inverse vulcanization by utilizing a commercially available triaziridine crosslinker as an alternative to conventional olefin-based crosslinkers. The model reactions reveal a self-catalyzed ring-opening of “unactivated” aziridine with elemental sulfur, forming oligosulfide-functionalized diamines. The triaziridine-derived polysulfides exhibit impressive mechanical properties, achieving a maximum stress of ~8.3 MPa and an elongation at break of ~107 %. The incorporation of silicon dioxide (20 wt %) enhances the composite's rigidity, yielding a Young's modulus of ~0.94 GPa. Furthermore, these polysulfides display excellent adhesion strength on various substrates, such as aluminum (~7.0 MPa), walnut (~9.6 MPa), and steel (~11.0 MPa), with substantial retention of adhesion strength (~3.3 MPa on steel) at −196 °C. The straightforward synthetic process, combined with the accessibility of the triaziridine crosslinker, emphasizes the potential for further innovations in sulfur polymer chemistry.}, archive = {J_ANGEW}, author = {Jieai Fan and Changzheng Ju and Songjie Fan and Xia Li and Zhen Zhang and Nikos Hadjichristidis}, doi = {10.1002/anie.202418764}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418764}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inverse vulcanization of aziridines: Enhancing polysulfides for superior mechanical strength and adhesive performance}, volume = {64}, year = {2025}, }
• (2025). Stable xanthene radicals and their heavy chalcogen analogues showing tunable doublet emission from green to near-infrared. ANGEW, 64(6), e202418762. (www)

  @article{ , abstract = {Organic luminescent radicals, unlike traditional closed-shell fluorescent emitters, exhibit distinct luminescence mechanisms, offering promising potential for optoelectronic devices. To date, stable luminescent radicals have predominantly been confined to polychlorinated triphenylmethyl radicals, underscoring the need for new platforms to expand their emission spectra. In this study, we report the synthesis of stable 9-aryl-substituted xanthene radicals and their heavy chalcogen analogues ( 1 a – c and 2 a – c ), which exhibited excellent chemical stability and emission ranging from green to near-infrared (527–714 nm). Notably, the selenium-substituted radical ( 1 c ) demonstrates a significantly enhanced photoluminescence quantum yield of 41 % when doped into its precursor solid. Additionally, the introduction of methoxyphenyl groups has largely enhanced the stability of the radical, showcasing an excellent photostability with the longest half-life of around 1792 h. The high internal quantum efficiency of up to 81 % was further validated in organic light-emitting diode. This study introduces a novel class of stable carbon-centered radicals with high tunability and functionality for photoelectric applications.}, archive = {J_ANGEW}, author = {Wanqing Jiang and Shaofei Wu and Duo Xu and Liangjing Tu and Yujun Xie and Pablo Pasqués-Gramage and Pedro G. Boj and María A. Díaz-García and Feng Li and Jishan Wu and Zhen Li}, doi = {10.1002/anie.202418762}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418762}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable xanthene radicals and their heavy chalcogen analogues showing tunable doublet emission from green to near-infrared}, volume = {64}, year = {2025}, }
• (2025). Metal-bridging cyclic bilatriene analogue affords stable π-radicaloid dyes with near-infrared II absorption. ANGEW, 64(6), e202418751. (www)

  @article{ , abstract = {Stable neutral metal radicaloid complexes have been synthesized from a modified tetrapyrrolic pigment, bilatriene, with iridium(I) and rhodium(I) cyclooctadiene (COD) synthons. The bilatriene skeleton contains α-linked conjugated pyrrole units, whereas an N-confused analogue used in this work possesses β-linked pyrrole moieties at the terminal, demonstrating a unique metal binding capability. Unprecedentedly, the metal-COD cations are accommodated at the outer nitrogen sites, which induced the formation of open-shell metal-radicaloid species. The resulting compounds are highly stable under ambient conditions and demonstrated facile redox conversion to afford the corresponding cation and anion species. Furthermore, the radicaloid complexes showed a distinct second near-infrared absorption (NIR-II) capability extending up to 1500 nm along with high photostability. These features emphasized that the complexes can be potential NIR-II light-responsible photothermal and photoacoustic imaging contrast agents based on the metal-radicaloid dye platform.}, archive = {J_ANGEW}, author = {Aninda Ghosh and Shigeki Mori and Yuki Ide and Jun Tae Song and Yoshihisa Yamaoka and Tatsumi Ishihara and Takahisa Ikeue and Hiroyuki Furuta and Masatoshi Ishida}, doi = {10.1002/anie.202418751}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418751}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-bridging cyclic bilatriene analogue affords stable π-radicaloid dyes with near-infrared II absorption}, volume = {64}, year = {2025}, }
• (2025). Electronic modulation and symmetry-breaking engineering of single-atom catalysts driving long-cycling Li−S battery. ANGEW, 64(6), e202418749. (www)

  @article{ , abstract = {Developing efficient and durable single-atom catalysts is vitally important for the sulfur redox reaction (SROR) in Li−S battery, while it remains enormous challenging. Herein, undercoordinated Ni−N 3 moieties anchored on N,S-codoped porous carbon (Ni−NSC) is obtained to enhance the SROR. The experiments and theoretical calculations indicate that the symmetry-breaking charge transfer in Ni single-atom catalyst originates from tuning effect of sulfur atoms mediated Ni−N 3 moieties, which can both facilitate the chemical adsorption by formation of N−Ni⋅⋅⋅S n 2− , and achieve a rapid redox conversion of polysulfides because of the enhanced electron transfer. As results, the Ni−NSC based Li−S battery delivers a very high initial reversible capacity (1025 mAh g −1 at 1 C), as well as outstanding cycling-stability for 2400 cycles at 2 C and 3 C, respectively. Noteworthy, the areal capacity can reach 7.8 mAh cm −2 at 0.05 C and a retention capacity of 4.7 mAh cm −2 after 100 cycles at 0.2 C for Ni−NSC based Li−S battery with sulfur loading of 5.88 mg cm −2 . This work provides profound insight for rational optimizing microscopic electronic density of active site to promoting SROR in metal-sulfur batteries.}, archive = {J_ANGEW}, author = {Fanchao Zhang and Zihuan Tang and Tengfei Zhang and Hong Xiao and Huifeng Zhuang and Pinyu Han and Lirong Zheng and Lei Jiang and Qiuming Gao}, doi = {10.1002/anie.202418749}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic modulation and symmetry-breaking engineering of single-atom catalysts driving long-cycling Li−S battery}, volume = {64}, year = {2025}, }
• (2025). Metallaphotoredox enabled single carbon atom insertion into alkenes for allene synthesis. ANGEW, 64(6), e202418746. (www)

  @article{ , abstract = {Efficient methods for synthesizing allenes from readily available starting materials pose a persistent challenge in organic chemistry. In this work, we present a novel two-stage protocol for allene synthesis involving the single-atom insertion into alkenes, facilitated by synergistic photoredox and cobalt catalysis. Diverging from conventional methods such as the Doering-LaFlamme reaction, this photochemical rearrangement approach operates efficiently under mild conditions in a radical-based manner. The protocol exhibits a broad substrate scope and demonstrates applicability in the late-stage diversification of alkene-containing natural products and bioactive molecules. Preliminary mechanistic studies and density functional theory (DFT) calculations offer insights into the reaction pathway, indicating a radical mechanism involving fleeting cyclopropyl carbene intermediates followed by rapid ring opening to form allenes.}, archive = {J_ANGEW}, author = {Gang Liu and Zhaoxin Shi and Chuning Guo and Danyu Gu and Zhaobin Wang}, doi = {10.1002/anie.202418746}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metallaphotoredox enabled single carbon atom insertion into alkenes for allene synthesis}, volume = {64}, year = {2025}, }
• (2025). π-lewis base activation of carbonyls and hexafluorobenzene. ANGEW, 64(6), e202418738. (www)

  @article{ , abstract = {We report hitherto elusive side-on η 2 -bonded palladium(0) carbonyl (anthraquinone, benzaldehyde) and arene (benzene, hexafluorobenzene) palladium(0) complexes and present the catalytic hydrodefluorination of hexafluorobenzene by cyclohexene. The comparison with respective cyclohexene, pyridine and tetrahydrofuran complexes reveals that the experimental ligand binding strengths follow the order THF<C 6 H 6 <C 6 F 6 <cyclohexene<pyridine<benzaldehyde<anthraquinone. To understand this surprising order, the complexes’ electronic structures were elucidated by nuclear magnetic resonance (NMR), single crystal X-Ray diffraction (sc-XRD), ultraviolet/visible (UV/Vis) electronic absorption, infrared (IR) vibrational, Pd L 3 -edge X-ray absorption (XAS), and X-ray photoelectron (XP) spectroscopic techniques, complemented by Density Functional Theory (DFT) calculations including energy decomposition (EDA-NOCV) and effective oxidation state (EOS) analyses. For benzene, pyridine and cyclohexene, bonding follows the donor/acceptor picture of the Dewar–Chatt–Duncanson model. In stark contrast, hexafluorobenzene, benzaldehyde and anthraquinone bind via essentially the π-channel only and thus as π-analogues of Z-acceptor ligands. This contribution elucidates the control of functional-group selectivity in palladium(0) catalysis and delineates a novel strategy to activate electron-deficient π-systems.}, archive = {J_ANGEW}, author = {Aditesh Mondal and Kevin Breitwieser and Sergi Danés and Annette Grünwald and Frank W. Heinemann and Bernd Morgenstern and Frank Müller and Michael Haumann and Maximilian Schütze and Dustin Kass and Kallol Ray and Dominik Munz}, doi = {10.1002/anie.202418738}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418738}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π-lewis base activation of carbonyls and hexafluorobenzene}, volume = {64}, year = {2025}, }
• (2025). Tuning proton affinity on Co−N−C atomic interface to disentangle activity-selectivity trade-off in acidic oxygen reduction to H2O2. ANGEW, 64(6), e202418713. (www)

  @article{ , abstract = {In oxygen reduction reaction to H 2 O 2 via two-electron pathway (2e − ORR), adsorption strength of oxygen-containing intermediates determines both catalytic activity and selectivity. However, it also causes activity-selectivity trade-off. Herein, we propose a novel strategy through modulating the interaction between protons and *OOH intermediates to break the activity-selectivity trade-off for highly active and selective 2e − ORR. Taking the typical cobalt–nitrogen–carbon single-atom catalyst as an example, boron heteroatoms doped into second coordination sphere of CoN 4 (Co 1 -NBC) increase proton affinity on catalyst surface, facilitating proton attack on the former oxygen of *OOH and thereby promoting H 2 O 2 formation. As a result, Co 1 -NBC simultaneously achieves prominent 2e − ORR activity and selectivity in acid with onset potential of 0.724 V vs . RHE and H 2 O 2 selectivity of 94 %, surpassing most reported catalysts. Furthermore, Co 1 -NBC exhibits a remarkable H 2 O 2 productivity of 202.7 mg cm −2 h −1 and a remarkable stability of 60 h at 200 mA cm −2 in flow cell. This work provides new insights into resolving activity-selectivity trade-off in electrocatalysis.}, archive = {J_ANGEW}, author = {Shanyong Chen and Tao Luo and Jingyu Wang and Jiaqi Xiang and Xiaoqing Li and Chao Ma and Cheng-wei Kao and Ting-Shan Chan and You-Nian Liu and Min Liu}, doi = {10.1002/anie.202418713}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418713}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning proton affinity on Co−N−C atomic interface to disentangle activity-selectivity trade-off in acidic oxygen reduction to H2O2}, volume = {64}, year = {2025}, }
• (2025). Sp carbon disrupting axial symmetry of local electric field for biomimetic construction of three-dimensional geometric and electronic structure in nanozyme for sensing and microplastic degradation. ANGEW, 64(6), e202418707. (www)

  @article{ , abstract = {The catalytic efficiency of natural enzymes depends on the precise electronic interactions between active centers and cofactors within a three-dimensional (3D) structure. Single-atom nanozymes (SAzymes) attempt to mimic this structure by modifying metal active sites with molecular ligands. However, SAzymes struggle to match the catalytic efficiency of natural enzymes due to constraints in active site proximity, quantity, and the inability to simulate electron transfer processes driven by internal electronic structures of natural enzymes. This study introduces a universal spatial engineering strategy in which molecular ligands are replaced with graphdiyne (GDY) to induce d-π orbital hybridization with copper nanoparticles (Cu NPs), leading to an asymmetric electron-rich distribution along the longitudinal axis that mimics the local electric field of natural laccase. Moreover, multiple sp bonds within GDY scaffold effectively anchor Cu NPs, facilitating the construction of 3D geometric structure similar to that of natural laccase. An enzymatic activity of 82.53 U mg −1 is achieved, 4.72 times higher than that of natural laccase. By reconstructing both 3D structures and local electric fields of natural enzymes through d-π orbital hybridization, this approach enhances electron interactions between cofactors, active centers, and substrates, and offers a versatile framework for biomimetic design of nanozymes.}, archive = {J_ANGEW}, author = {Yujian Sun and Chenguang Wang and Haoxin Li and Kai Wang and Qiang Bai and Guoli Zhang and Shuishui Feng and Lina Wang and Zhiling Zhu and Ning Sui}, doi = {10.1002/anie.202418707}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sp carbon disrupting axial symmetry of local electric field for biomimetic construction of three-dimensional geometric and electronic structure in nanozyme for sensing and microplastic degradation}, volume = {64}, year = {2025}, }
• (2025). Radiation-sensitive layered hybrid double perovskites driven by a dual-ion-woven supramolecular framework for X-ray tomography. ANGEW, 64(6), e202418701. (www)

  @article{ , abstract = {A promising candidate for X-ray detection is layered hybrid double perovskites (LHDPs) with excellent structural stability, but their sensitivity is generally limited by unsatisfactory interlayer charge transport. Herein, employing one ethylenediamine (EDA) chain as a structural inducer, we successfully obtain unusual Dion-Jacobson (DJ) phase LHDPs, (EDABr) 4 AgBiBr 8 and (EDABr) 4 CuBiBr 8 , featuring a Ruddlesden-Popper-like (RP-like) interlayer. Thanks to the bridging of bromine anions, organic cations are linked via charge-assisted hydrogen bonds, where two ionic spacers are orderly woven into a supramolecular framework. Consequently, the RP-like interlayer space is regulated by the dual-ion-woven supramolecular framework with embedded charge-assisted hydrogen bond networks, remarkably enriching interlayer interactions and boosting charge transport. Through theoretical calculations, structural roles of the supramolecular framework are elucidated by extra orbital contribution and large diffusion barrier of Br anions. As proof of concept, the sensitivity of RP-like devices up to 5250 μC Gy air −1 cm −2 is a record-high of LHDP-based X-ray detectors for now, while a low detection limit (91 nGy air s −1 ) and outstanding radiation-resistant capability (50 Gy air ) are achieved. Moreover, an oriented membrane device is prepared to demonstrate high-performance X-ray tomography. These findings offer a brand-new interlayer-modulation strategy for the construction of sensitive and stable scintillation semiconductors.}, archive = {J_ANGEW}, author = {Xieming Xu and Hao Lu and Xiong Zhang and Lian Wang and Guiqing Feng and Luying Zheng and Xiaoming Jiang and Shaofan Wu and Shuaihua Wang}, doi = {10.1002/anie.202418701}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radiation-sensitive layered hybrid double perovskites driven by a dual-ion-woven supramolecular framework for X-ray tomography}, volume = {64}, year = {2025}, }
• (2025). Cooperative active sites on Ag2Pt3TiS6 for enhanced low-temperature ammonia fuel cell electrocatalysis. ANGEW, 64(6), e202418691. (www)

  @article{ , abstract = {Ammonia has attracted considerable interest as a hydrogen carrier that can help decarbonize global energy networks. Key to realizing this is the development of low temperature ammonia fuel cells for the on-demand generation of electricity. However, the efficiency of such systems is significantly impaired by the sluggish ammonia oxidation reaction (AOR) and oxygen reduction reaction (ORR). Here, we report the design of a bifunctional Ag 2 Pt 3 TiS 6 electrocatalyst that facilitates both reactions at mass activities exceeding that of commercial Pt/C. Through comprehensive density functional theory calculations, we identify that active site motifs composed of Pt and Ti atoms work cooperatively to catalyze ORR and AOR. Notably, in situ shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) experiments indicate a decreased propensity for *NO x formation and hence an increased resistance toward catalyst poisoning for AOR. Employing Ag 2 Pt 3 TiS 6 as both the cathode and anode, we constructed a low temperature ammonia fuel cell with a high peak power density of 8.71 mW cm −2 and low Pt loading of 0.45 mg cm −2 . Our findings demonstrate a pathway towards the rational design of effective electrocatalysts with multi-element active sites that work cooperatively.}, archive = {J_ANGEW}, author = {Tong Wu and Kapil Dhaka and Mengjia Luo and Bingqing Wang and Meng Wang and Shibo Xi and Mingsheng Zhang and Fuqiang Huang and Kai S. Exner and Yanwei Lum}, doi = {10.1002/anie.202418691}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418691}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cooperative active sites on Ag2Pt3TiS6 for enhanced low-temperature ammonia fuel cell electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Solvent polarity-induced regulation of cation solvation sheaths for high-voltage zinc-based batteries with a 1.94 v discharge platform. ANGEW, 64(6), e202418682. (www)

  @article{ , abstract = {To address the challenge of low discharge platforms (<1.5 V) in aqueous zinc-based batteries, highly concentrated salts have been explored due to their wide electrochemical window (~3 V). However, these electrolytes mainly prevent hydrogen evolution and dendrite growth at the anode without significantly enhancing voltage performance. Herein we introduce an approach by adjusting solvent polarity to regulate cation solvation sheaths in hybrid electrolytes, reducing Zn/Zn 2+ oxidation potential and water activity. Through strong cation-water coordination and hydrogen bonding between dimethylsulfoxide and water, the designed electrolyte, at a low concentration, achieves a broader electrochemical window (4 V) than conventional concentrated electrolytes. Using this electrolyte, a Zn/Zn battery showed an impressive cycle life of 4340 cycles, while a Zn/lithium manganate battery delivered a high discharge platform of over 1.9 V with exceptional cycling stability. A Zn-based micro-battery with a polyvinyl alcohol-based hybrid electrolyte also achieved a record-high discharge platform of 1.94 V. This work presents a promising strategy for developing low-concentration electrolytes for high-performance sustainable energy storage.}, archive = {J_ANGEW}, author = {Xuting Jin and Guobin Lai and Xinyi Xiu and Li Song and Xiangyang Li and Chunlong Dai and Meng Li and Zhonggui Quan and Bin Tang and Gonglei Shao and Zhipan Zhang and Feng Liu and Liangti Qu and Zhen Zhou}, doi = {10.1002/anie.202418682}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418682}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent polarity-induced regulation of cation solvation sheaths for high-voltage zinc-based batteries with a 1.94 v discharge platform}, volume = {64}, year = {2025}, }
• (2025). Reassessing the photochemical upcycling of polystyrene using acridinium salts. ANGEW, 64(6), e202418680. (www)

  @article{ , abstract = {Polystyrene ( PS ) is a commodity plastic recalcitrant to chemical recycling or upcycling processes. Approaches aimed at deconstructing PS by photocatalytic means struggle to generate high-energy species capable of cleaving the robust C−H and C−C bonds of PS . We show that 9-mesityl-10-methylacridinium perchlorate ( MA ) is capable of upcycling various grades of PS substrates into up to 40 % benzoic acid ( BAc ), formic acid ( FA ) and small proportions of acetophenone ( ACP ), under visible light (456 nm) or through solar radiation. Time-resolved emission and absorption spectroscopy evidence that a reaction with oxygen is the primary photochemical step in oxygen-saturated solutions, accounting for 77 % of the photons absorbed vs. 1 % for the direct reaction with PS (0.303 M in repeating units). These results are in agreement with a mechanism in which MA -mediated photo upcycling of PS to BAc occurs through the abstraction of benzylic H atoms by reactive oxygen species generated by energy or electron transfer from the excited state of MA . Addition of triplet O 2 to these radicals, followed by intra- or inter-molecular hydrogen atom transfer (HAT) generates C- or O-centered radicals then undergoing β-scission or hydroperoxide fragmentation. The formation of intermediate oligomers functionalized by terminal carbonyl groups is demonstrated by both infrared analysis and MALDI TOF mass spectrometry. These oligomers undergo further photoinduced conversion even in the absence of MA , as evidenced by size exclusion chromatography analysis of the irradiated samples.}, archive = {J_ANGEW}, author = {Anne-Lise De Abreu and Daniel Taton and Dario M. Bassani}, doi = {10.1002/anie.202418680}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reassessing the photochemical upcycling of polystyrene using acridinium salts}, volume = {64}, year = {2025}, }
• (2025). Mild-condition photocatalytic reforming of methanol-water by a hierarchical, asymmetry carbon nitride. ANGEW, 64(6), e202418677. (www)

  @article{ , abstract = {As a reproducible intermediate for hydrogen (H 2 ) and carbon cycling, methanol mixed with water (H 2 O) in a ratio of 1 : 1 can multiply the outcome of green H 2 generation via Photocatalytic reforming of methanol-H 2 O (PRMW). Hitherto, low-energy and mild-condition PRMW remains a serious challenge. Here, the amino acid-derived carbon nitrides (ACN) were synthesized supramolecular precursor strategy for PRMW and achieved excellent performance (H 2 , 35.6 mmol h −1 g −1 ; CO 2 , 11.5 mmol h −1 g −1 ) under sunlight at 35 °C. It was revealed that the surface-terminating carboxyl groups (−COOH) promote the dark dehydrogenation of methanol on MetCN x to form methoxy (*OCH 3 ) and methylol (*CH 2 OH) simultaneously, with the hydroxyl (*OH) generated by photostimulated H 2 O oxidation promotes the C−H activation of formaldehyde, then leads the whole reaction into the formation of CO 2 and three H 2 . The extended light absorption, enhanced charge separation and transport, and efficient surface reaction improve photocatalytic efficiency.}, archive = {J_ANGEW}, author = {Baogang Wu and Baojiang Jiang and Changliang Guo and Jiawei Zhang and Qi Li and Nan Wang and Zichen Song and Chungui Tian and Markus Antonietti and Honggang Fu}, doi = {10.1002/anie.202418677}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418677}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mild-condition photocatalytic reforming of methanol-water by a hierarchical, asymmetry carbon nitride}, volume = {64}, year = {2025}, }
• (2025). Shape-selective zeolites for tandem CO2 hydrogenation-carbonylation reactions. ANGEW, 64(6), e202418670. (www)

  @article{ , abstract = {The valorization of carbon dioxide as a C1 building block in C−C bond forming reactions is a critical link on the road to carbon-circular chemistry. Activation of this inert molecule through reduction with H 2 to carbon monoxide in the reverse water-gas shift (RWGS) reaction can be followed by a wide spectrum of consecutive carbonylation reactions, but the RWGS is severely equilibrium limited at the moderate temperatures of carbonylations. Here we successfully reconcile both reactions in one pot, while avoiding incompatibilities through a zeolite-based compartmentalized approach. More specifically, Pt encapsulated in a small-pore LTA zeolite selectively generates carbon monoxide in mild reaction conditions; an ensuing one-pot carbonylation reaction allows to shift the equilibrium through continuous consumption of CO. Moreover, the zeolite encapsulation avoids undesired reactions like hydrogenation of the olefin reactant through a molecular sieving effect. This strategy was first studied in-depth for Rh-catalyzed olefin hydroformylation with CO 2 /H 2 , affording aldehydes in good yields with high regioselectivities. The methodology was then extended to a variety of carbonylations using CO 2 for the synthesis of bulk and fine chemicals.}, archive = {J_ANGEW}, author = {Hendrik Van Dessel and Sam Van Minnebruggen and Jasper Dedapper and Paul Paciok and Oleg Usoltsev and Andraž Krajnc and Aram Bugaev and Dirk E. De Vos}, doi = {10.1002/anie.202418670}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418670}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Shape-selective zeolites for tandem CO2 hydrogenation-carbonylation reactions}, volume = {64}, year = {2025}, }
• (2025). Multidentate chelating ligands enable high-performance zinc-bromine flow batteries. ANGEW, 64(6), e202418669. (www)

  @article{ , abstract = {Zinc bromine flow battery (ZBFB) is a promising battery technology for stationary energy storage. However, challenges specific to zinc anodes must be resolved, including zinc dendritic growth, hydrogen evolution reaction, and the occurrence of “dead zinc”. Traditional additives suppress side reactions and zinc dendrite formation by altering the solvation structure of Zn 2+ and adsorbing onto the zinc surface through only a limited number of zincophilic sites, resulting in weak adsorption on zinc metal and potential inability to simultaneously optimize the solvation structure of zinc ions. Obviously, increasing the number of potential zincophilic sites in the additive can significantly enhance the interaction with zinc. Herein, we propose a strong chelate, ethylenediamine tetramethylene phosphonic acid (EDTMPA) as the additive, which boasts six potent zincophilic sites, not only promotes the formation of the water-deficient inner Helmholtz plane but also plays a crucial role in restructuring the solvation environment of Zn 2+ . As a result, the zinc symmetric flow battery with EDTMPA exhibited exceptional coulombic efficiency of 99.4 % over 800 cycles, surpassing the previous studies by a significant margin. Furthermore, the assembled ZBFB has showcased a dendrite-free and enduring cycling over 400 cycles at 80 mA cm −2 .}, archive = {J_ANGEW}, author = {Weicheng Xia and Kunchi Xie and Shang Gao and Zhen Song and Long Chen and Chunzhong Li}, doi = {10.1002/anie.202418669}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multidentate chelating ligands enable high-performance zinc-bromine flow batteries}, volume = {64}, year = {2025}, }
• (2025). Selenium dioxide catalyzed polymerization of N-doped poly(benzodifurandione) (n-PBDF) and its derivatives. ANGEW, 64(6), e202418668. (www)

  @article{ , abstract = {The recent discovery of highly conductive, solution-processable, n-doped poly(benzodifurandione) (n-PBDF) marks a milestone in the development of conducting polymers. Currently, n-PBDF is prepared by either duroquinone-mediated or copper-catalyzed polymerizations, where scalability and cost-effectiveness may present challenges. Here, we report a general, scalable, and cost-effective method for n-PBDF and its derivatives, namely selenium dioxide (SeO 2 ) catalyzed polymerization. We discovered that a catalytic amount of selenium dioxide leads to high monomer conversions (>99 % by NMR). The obtained n-PBDF exhibits a consistently narrow hydrodynamic diameter distribution and its thin films show high conductivities. Furthermore, we revealed that this polymerization involves a mechanism distinct from the previously reported radical pathway. It involves successive Riley oxidation and aldol polycondensation processes. It was also found that the reduced selenium precipitates from dimethyl sulfoxide (DMSO) when the catalytic cycle is terminated, allowing for a straightforward purification process through centrifugation and filtration. This method thus eliminates the need for the costly and slow dialysis process. Finally, we demonstrated that SeO 2 catalyzed polymerization is applicable to n-PBDF derivatives, proving the generality of this method.}, archive = {J_ANGEW}, author = {Guangchao Liu and Hsuan-Hao Hsu and Sanket Samal and Won-June Lee and Zhifan Ke and Liyan You and Brett M. Savoie and Jianguo Mei}, doi = {10.1002/anie.202418668}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418668}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selenium dioxide catalyzed polymerization of N-doped poly(benzodifurandione) (n-PBDF) and its derivatives}, volume = {64}, year = {2025}, }
• (2025). Transition metal as template: Reversing the synthesis logic in the preparation of pincer complexes. ANGEW, 64(6), e202418663. (www)

  @article{ , abstract = {The conventional synthetic approach to transition metal pincer complexes calls for the preparation of the tridentate pincer (pro)ligand first, with subsequent introduction of the transition metal center as the last step. This work demonstrates that the alternative synthetic logic, where the central main group element is introduced last, can be applicable to a number of PEP pincer complexes (E=B, Al, Si, P) derived from phosphinophenols and phosphinopyrroles. This approach obviates the need to isolate well-behaved propincer precursors, and instead relies on the formation of phosphine-metal adducts first, whose nature determines the stoichiometry of the needed main group reagent to complete the synthesis.}, archive = {J_ANGEW}, author = {Jovanny J. Contreras and Samuel R. Lee and Vinh T. Nguyen and Thomas Suarez and Derek W. Leong and Nattamai Bhuvanesh and Miles W. Johnson and Oleg V. Ozerov}, doi = {10.1002/anie.202418663}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418663}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transition metal as template: Reversing the synthesis logic in the preparation of pincer complexes}, volume = {64}, year = {2025}, }
• (2025). Energy transfer (EnT) catalysis of non-symmetrical borylated dienes: Origin of reaction selectivity in competing EnT processes. ANGEW, 64(6), e202418651. (www)

  @article{ , abstract = {Energy transfer catalysis (EnT) has had a profound impact on contemporary organic synthesis enabling the construction of higher in energy, complex molecules, via efficient access to the triplet excited state. Despite this, intermolecular reactivity, and the unique possibility to access several reaction pathways via a central triplet diradical has rendered control over reaction outcomes, an intractable challenge. Extended chromophores such as non-symmetrical dienes have the potential to undergo [2+2] cycloaddition, [4+2] cycloaddition or geometric isomerisation, which, in combination with other mechanistic considerations (site- and regioselectivity), results in chemical reactions that are challenging to regulate. Herein, we utilise boron as a tool to probe reactivity of non-symmetrical dienes under EnT catalysis, paying particular attention to the impact of boron hybridisation effects on the target reactivity. Through this, a highly site- and regioselective [2+2] cycloaddition was realised with the employed boron motif effecting reaction efficiency. Subtle modifications to the core scaffold enabled a [4+2] cycloaddition, while a counterintuitive regiodivergence was observed in geometric isomerisation versus [2+2] cycloaddition. The observed reactivity was validated via a mechanistic investigation, determining the origin of regiodivergence and reaction selectivity in competing EnT processes.}, archive = {J_ANGEW}, author = {Hao Fang and Alejandro García-Eguizábal and Yu Jen Hsueh and Constantin G. Daniliuc and Ignacio Funes-Ardoiz and John J. Molloy}, doi = {10.1002/anie.202418651}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Energy transfer (EnT) catalysis of non-symmetrical borylated dienes: Origin of reaction selectivity in competing EnT processes}, volume = {64}, year = {2025}, }
• (2025). A highly active molybdenum carbide catalyst with dynamic carbon flux for reverse water-gas shift reaction. ANGEW, 64(6), e202418645. (www)

  @article{ , abstract = {Molybdenum carbide has been reported as an efficient and stable catalyst for reverse water-gas shift (RWGS) reaction. The conventional understanding of the mechanism suggests domination of the surface phenomena, with only surface or subsurface layers partaking in the catalytic cycle. In this study, we presented a highly active MoC catalyst from carburization process, which showed a mass-specific reaction rate over 260 μm with dynamic carbon flux in the bulk phase of the catalyst. Through Isotopic Temperature-Programmed Reaction (ITPR) analysis and Environmental Transmission Electron Microscopy (ETEM), we discerned dynamic carbon flow circulating between the α-MoC bulk phase and the gas phase reactants under the RWGS reaction atmosphere. This circulation, essential to maintaining the structural stability of the metastable α-MoC and its ultra-high reactivity, is accompanied by thorough carbon component exchange among the bulk, the surface and the gas-phase reactants during the reaction process.}, archive = {J_ANGEW}, author = {Mengtao Zhang and Yuchen Zhu and Jie Yan and Junzhong Xie and Tao Yu and Mi Peng and Jiayun Zhao and Yao Xu and Aowen Li and ChunJiang Jia and Lin He and Meng Wang and Wu Zhou and Rongming Wang and Hong Jiang and Chuan Shi and Jose Rodriguez and Ding Ma}, doi = {10.1002/anie.202418645}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly active molybdenum carbide catalyst with dynamic carbon flux for reverse water-gas shift reaction}, volume = {64}, year = {2025}, }
• (2025). Rapid surface reconstruction of amorphous-crystalline NiO for industrial-scale electrocatalytic PET upcycling. ANGEW, 64(6), e202418640. (www)

  @article{ , abstract = {The conversion of plastic waste into valuable chemicals through innovative and selective nano-catalysts offers significant economic benefits and positive environmental impacts. However, our current understanding of catalyst design capable of achieving industrial-grade current densities is limited. Herein, we develop a self-supported amorphous-crystalline NiO electrocatalyst for the electrocatalytic upcycling of polyethylene terephthalate (PET) into formate and hydrogen fuel. The catalyst achieves an industrial current density of over 1 A cm −2 at 1.5 V vs. RHE, with an 80 % Faradaic efficiency and a formate production rate of 7.16 mmol cm −2 h −1 . In situ Raman spectroscopy, X-ray absorption spectroscopy, and density functional theory calculations reveal that the rapid transformation of amorphous-crystalline NiO into γ-NiOOH at the amorphous-crystalline interface provides a thermodynamic advantage for formate desorption, leading to the high activity required for industrial applications, which is challenging to achieve for fully crystalline NiO. A techno-economic analysis indicates that recycling waste PET using this catalytic process could generate a profit of $582 per ton. This work presents a cost-effective and highly efficient approach to promoting the sustainable utilization of waste PET.}, archive = {J_ANGEW}, author = {Wei Ding and Dongxiao Ji and Kangkang Wang and Yinghui Li and Qingliang Luo and Rongwu Wang and Linlin Li and Xiaohong Qin and Shengjie Peng}, doi = {10.1002/anie.202418640}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418640}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid surface reconstruction of amorphous-crystalline NiO for industrial-scale electrocatalytic PET upcycling}, volume = {64}, year = {2025}, }
• (2025). Polyoxometalate confined synthesis of BiVO4 nanocluster for urea production with remarkable O2/N2 tolerance. ANGEW, 64(6), e202418637. (www)

  @article{ , abstract = {Urea electrosynthesis from flue gas and NO 3 − under operating conditions represents a promising alternative technology to traditional energy-intensive industrial process. Herein, we explore a polyoxometalate confined synthesis strategy to prepare ultrafine BiVO 4 nanocluster by pre-incorporating [V 10 O 28 ] 6− into NH 2 -MIL-101-Al (MIL) framework. The resulting BiVO 4 @MIL-n can efficiently drive co-reduction of NO 3 − and CO 2 to urea. A record urea yield of 63.4 mmol h −1 g cat −1 was achieved under CO 2 /O 2 mixed gases (33 % O 2 ) atmosphere, and comparable performance can be obtained by feeding flue gas, demonstrating remarkable O 2 /N 2 tolerance and potential feasibility for urea production under operating conditions. Systematic investigations revealed that MIL carrier with -NH 2 group can enrich CO 2 , and BiVO 4 nanocluster can reduce both NO 3 − and CO 2 to ensure efficient urea synthesis even in the presence of O 2 . This work demonstrates the key role of in situ growth of BiVO 4 nanocluster within a NH 2 -framework in facilitating urea electrosynthesis with exceptional tolerance to O 2 /N 2 .}, archive = {J_ANGEW}, author = {Shuang Yao and Shi-Yi Jiang and Bai-Fan Wang and Hua-Qing Yin and Xue-Yan Xiang and Zhao Tang and Chang-Hua An and Tong-Bu Lu and Zhi-Ming Zhang}, doi = {10.1002/anie.202418637}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyoxometalate confined synthesis of BiVO4 nanocluster for urea production with remarkable O2/N2 tolerance}, volume = {64}, year = {2025}, }
• (2025). Complementary reducing agents are responsible for temporally distinct nucleation and growth phases during the polyol synthesis of ag nanocubes. ANGEW, 64(6), e202418611. (www)

  @article{ , abstract = {Ethylene glycol or one of its oxidation products are believed to serve as reducing agents in the shape-controlled synthesis of Ag nanocubes (NCs) by the polyol process. The identity of end-groups of polyvinylpyrrolidone (PVP) impacts shape control with alcohol and aldehyde moieties serving as a primary Ag reducing agent. We explored the role of PVP end-groups in the polyol process by measuring the dependence of particle number density of Ag NCs produced on the initial concentration(s) of Ag and PVP using small angle x-ray scattering and statistically large particle size distributions analyzed by scanning electron microscopy. The number density of Ag NCs is strongly dependent on the starting concentration of PVP chains demonstrating PVP end-groups play an important role in the nucleation of NCs. The concentration of Ag + is 2 orders of magnitude higher than the end-groups suggesting ethylene glycol must participate in the reduction of Ag + during growth. Perturbation experiments and analysis of resultant particle size distribution reveal nucleation is fast relative to growth of NCs, reinforcing the synergy between PVP end-groups and ethylene glycol. The evidence demonstrates PVP end-groups and ethylene glycol are tandem reducing agents operative in temporally distinct phases of the polyol synthesis of Ag NCs.}, archive = {J_ANGEW}, author = {Griffin A. Canning and Susanna Ogozaly and Matthew Pekarcik and Christopher A. Lieb and Suprita Jharimune and Rueben Pfukwa and Bert Klumperman and Robert M. Rioux}, doi = {10.1002/anie.202418611}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418611}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Complementary reducing agents are responsible for temporally distinct nucleation and growth phases during the polyol synthesis of ag nanocubes}, volume = {64}, year = {2025}, }
• (2025). Controllable heavy n–type behaviours in inverted perovskite solar cells with non-conjugated passivants. ANGEW, 64(6), e202418606. (www)

  @article{ , abstract = {Interfacial issues between the perovskite film and electron transport layer greatly limit the efficiency and stability of inverted ( p-i-n ) perovskite solar cells (PSCs). Despite organic ammonium passivants have been widely established as interfacial layers, they failed to improve electron extraction. Here, we reported that the heavy n-type characteristics in a low band gap perovskite film could be modulated by incorporating non-conjugated ammonium passivants with strong electron-withdrawing abilities. This resulted in a significant enhancement of electron extraction in the heavily n -type doped perovskite. The passivant-treated PSCs exhibited a power conversion efficiency of 25.74 % with an excellent fill factor of 85.4 % and a high open-circuit voltage of 1.166 V, which are significantly higher than that of the control device. The unencapsulated devices maintained 88 % of their initial PCEs after 1,200 hours at 85 °C.}, archive = {J_ANGEW}, author = {Haowei Guan and Jie Wu and Daobin Yang and Lisha Xie and Weifu Zhang and Jiahong Shan and Zhongqiang Wang and Yuanyuan Meng and Jintao Zhu and Fei Chen and Yubo Zhou and Ziyi Ge}, doi = {10.1002/anie.202418606}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418606}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controllable heavy n–type behaviours in inverted perovskite solar cells with non-conjugated passivants}, volume = {64}, year = {2025}, }
• (2025). Halting oxygen evolution to achieve long cycle life in sodium layered cathodes. ANGEW, 64(6), e202418605. (www)

  @article{ , abstract = {Oxygen redox chemistries at high voltage have materialized as a revolutionary paradigm for cathodes with high-energy density; however, they are plagued by the challenges of labile oxygen loss and rapid degradations upon cycling, even after concerted endeavors from the research community. Here we propose a multi-concentration stratagem propelled by entropy reinforcement to enhance the electronic structure disorder (ESD) at high desodiation states for impeding undesired oxygen mobility and ensuring controlled oxygen activity, elucidated by density functional theory calculations. The increased disorder strengthens the reversible electrochemistry of lattice oxygen redox, leading to effectively suppressed P−O structural evolution and highly stable localized TMO 6 octahedral environments, as demonstrated by soft/hard X-ray absorption spectroscopy. Furthermore, through a comparative analysis of sodium-layered cathodes with different configuration entropy, we reveal that a high-entropy state induced by cationic disordering has the capacity to perturb cationic redox boundaries, significantly restraining the formation of detrimental O′3 phases. As a consequence, the high-voltage cycling stability has been greatly upgraded, up to 4.4 V versus Na + /Na, with an impressive 90.1 % capacity retention at 1 C over 100 cycles and 76.1 % capacity retention at 2 C over 300 cycles. The resilient oxygen redox, enabled through the control of ESD, broadens the horizons for entropy engineering and lays the foundation for advancements in high-energy, long-cycling, and safe batteries.}, archive = {J_ANGEW}, author = {Haoji Wang and Jinqiang Gao and Yu Mei and Lianshan Ni and Yi He and Ningyun Hong and Jiangnan Huang and Wentao Deng and Guoqiang Zou and Hongshuai Hou and Tongchao Liu and Chaoping Liang and Xiaobo Ji and Khalil Amine}, doi = {10.1002/anie.202418605}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418605}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halting oxygen evolution to achieve long cycle life in sodium layered cathodes}, volume = {64}, year = {2025}, }
• (2025). The effect of electric fields on oxidization processes at the air-water interface. ANGEW, 64(6), e202418593. (www)

  @article{ , abstract = {At the air–water interface, many reactions are accelerated, sometimes by several orders of magnitude. This phenomenon has proved to be particularly important in water microdroplets, where the spontaneous oxidation of many species stable in bulk has been experimentally demonstrated. Different theories have been proposed to explain this finding, but it is currently believed that the role of interfacial electric fields is key. In this work, we have carried out a quantum chemistry study aimed at shedding some light on this question. We have studied two prototypical processes in which a hydroxide anion transfers its excess electron to either the water environment or a dioxygen molecule. To model the interface, we use a cluster of 21 water molecules immersed in an electric field, and we examine the energetics of the studied reactions as a function of field magnitude. Our results reveal that electric fields close to those estimated for the neat air–water interface (∼0.15 V ⋅ Å −1 ) have a moderate effect on the reaction energetics and that much stronger fields (>1 V ⋅ Å −1 ) are required to get spontaneous electron transfer. Therefore, the study suggests that additional factors such as an excess charge in microdroplets need to be considered for explaining the experimental observations.}, archive = {J_ANGEW}, author = {Marilia T. C. Martins-Costa and Manuel F. Ruiz-López}, doi = {10.1002/anie.202418593}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The effect of electric fields on oxidization processes at the air-water interface}, volume = {64}, year = {2025}, }
• (2025). Enhanced UV light responsivity in <110>-oriented 2D perovskites realized by pressure-induced ultrafast exciton transport. ANGEW, 64(6), e202418587. (www)

  @article{ , abstract = {Two-dimensional (2D) <100>-oriented perovskites exhibit superior optoelectronic properties, offering significant potential in photovoltaic, light-emitting, and photodetection applications. Nevertheless, their enlarged interlayer spacing restricts longitudinal carrier transport, thereby limiting its potential applications. While <110>-oriented 2D perovskites provide a prospective solution with their compact interlayer spacing, their inherent structure, characterized by octahedra tilting, indirectly hinders carrier transport due to the generation of self-trapped excitons (STEs) caused by strong electron-phonon coupling. Here, we adeptly regulate the photoluminescence (PL) from STEs to free excitons (FEs) emission within the 2D <110>-oriented (API)PbBr 4 single crystal through structure optimization under pressure treatment. Besides, we observed anisotropic FE transport with an anisotropy ratio of 4.97. The exciton mobility reaches a peak of 93.6 cm 2 V −1 s −1 at 2.7 GPa, a value comparable to those of their three-dimensional (3D) counterparts, which is attributed to a reduction in electron-phonon coupling and exciton reduced mass. Additionally, this ultrafast exciton transport significantly enhances UV light responsivity, exhibiting an increase of approximately 5000 times at 2.7 GPa in comparison to ambient conditions. These findings highlight the prospective application of 2D <110>-oriented perovskites in high-performance optoelectronic devices through intrinsic structural modulation.}, archive = {J_ANGEW}, author = {Yanfeng Yin and Xianchang Yan and Hui Luo and Yongfu Liang and Peng Xu and Yiming Wang and Shengye Jin and Wenming Tian}, doi = {10.1002/anie.202418587}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418587}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced UV light responsivity in <110>-oriented 2D perovskites realized by pressure-induced ultrafast exciton transport}, volume = {64}, year = {2025}, }
• (2025). The hidden mechanism: Excited-state proton-electron pair transfer in metal nanocluster emission. ANGEW, 64(6), e202418560. (www)

  @article{ , abstract = {Comprehending the underlying factors that govern photoluminescence (PL) in metal nanoclusters (NCs) under physiological conditions remains a highly intriguing and unresolved challenge, particularly for their biomedical applications. In this study, we evaluate the critical role of excited-state proton-coupled electron transfer in the emission of metal NCs. Our findings demonstrate that hydronium ion (H 3 O + ) binding can trigger a nonlinear, pH-dependent excited-state concerted electron proton transfer (CEPT) reaction. This involves simultaneous electron transfer from the Au(0) core to the Au(I)−ATT (ATT denotes 6-aza-2-thiothymidine) surface and proton transfer from H 3 O + to the ATT ligand in a single step, greatly promoting vibrations and rotations of the Au(I)−ATT surface, resulting in substantial PL quenching of Au 10 (ATT) 6 NCs. Further analyses show that the unique CEPT dynamics are strongly influenced by the opposing effects of increased reorganization energy and a larger pre-exponential factor on the electron transfer rate. Moreover, the proposed excited-state CEPT process is found to be prevalent in core–shell relaxation metal NCs, such as Au 25 (SR) 18 (SR denotes thiolate) NCs, and serves as an important factor in limiting their PL emission. By simply controlling the p K a of the ligands, the emission performance of Au 25 (SR) 18 can be easily regulated in physiological environments.}, archive = {J_ANGEW}, author = {Kai-Yuan Huang and Yan-Yan Chen and Wen-Lu Wang and Wei-Ming Sun and Zhen Lin and Qiaofeng Yao and Wei Chen and Jianping Xie and Hao-Hua Deng}, doi = {10.1002/anie.202418560}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418560}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The hidden mechanism: Excited-state proton-electron pair transfer in metal nanocluster emission}, volume = {64}, year = {2025}, }
• (2025). Ultra-rapid synthesis of high-entropy MAX phases and their derivative MXenes for battery electrodes. ANGEW, 64(6), e202418538. (www)

  @article{ , abstract = {High-entropy materials hold immense promise for energy storage, owing to their varied compositions and unforeseen physicochemical properties, yet, which poses challenges in synthesis due to tendentious phase separation and extended sintering durations. Herein, an ultra-rapid strategy based on spark plasma sintering (SPS) techniques is proposed to synthesize high-entropy MAX phases within 15 minutes, including a new phase of (Ti 0.2 V 0.2 Cr 0.2 Nb 0.2 Mo 0.2 ) 4 AlC 3 and several phases of 413-type TiVNbMoAlC 3 , TiVCrMoAlC 3 and (Ti 0.2 V 0.2 Cr 0.2 Nb 0.2 Ta 0.2 ) 4 AlC 3 , achieving utmost purity level up to 99.54 %. Under high temperature, the overfeed of Al with low melt point (~660 °C) can foster a liquid environment, which remits the immiscibility among starting materials and benefits to diffusion dynamics to some extents. Theoretical calculations are employed to elucidate the thermodynamic preponderance of high-entropy MAX phases in the intricate multi-element systems. Meanwhile, the varied stacking modes among MX slabs in high-entropy MAX phases and the distinct topological transformations to their derivative MXenes can be observed directly at the atomic level. Moreover, four high-entropy MXenes as electrode materials were investigated for rechargeable batteries. Among them, TiVNbMoC 3 electrode demonstrates superior lithium-ion storage capabilities with 725 mAh g −1 after 1000 cycles at 1 A g −1 , triggering the edification to the application of high-entropy MXenes for energy domain.}, archive = {J_ANGEW}, author = {Liang Zhang and Huicong Li and Xiaoyu Zhang and Chunxue Liu and Yifei Sun and Yiyuan Zhang and Zhen Fang and Jiangang He and Rongming Wang and Kai Jiang and Di Chen}, doi = {10.1002/anie.202418538}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418538}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-rapid synthesis of high-entropy MAX phases and their derivative MXenes for battery electrodes}, volume = {64}, year = {2025}, }
• (2025). Facile access to phosphorus ylide-fused heteroarenes possessing tunable optoelectronic properties and high nonlinear optical performances. ANGEW, 64(6), e202418520. (www)

  @article{ , abstract = {We report here a novel family of ylidic P-heteroarenes ( P1 – P6 ), structurally featuring unique phosphonium cyclopentadienylide (P−Cp)-fused π-skeletons and synthetically prepared via an unexpected one-pot [2+3]/[3+3] phospha-annulation reaction. While the facile and modular synthesis allows the fine-tuning of their optical absorptions and redox properties, single-crystallographic and theoretical analysis of these P-heteroarenes further reveal that the fusion of P−Cp moiety leads to substantial intramolecular charge-separated features with high ylidic character values of up to 84 %. Benefitted from such dipolar structures, these P-heteroarenes not only allows stepwise electrophilic substitution reaction for further structural π-expansions, but also exhibit excellent nonlinear optical (NLO) responses and optical limiting (OL) performances comparable to or exceed those of C 60 . As a model compound, the persistent radical-anion salt of P5a was also prepared through chemical reduction, thus offering valuable insights into the electronic structures of reduced P-ylidic species. Our work not only established a highly efficient synthetic method toward new P-heteroarenes, but also provide fundamental understanding of those fused-ring ylidic P-heterocycles with promising NLO/OL applications.}, archive = {J_ANGEW}, author = {Kaihua Zhang and Xiaofeng Wang and Zhiruo Zhou and Jing Guo and Hao Liu and Yaxin Zhai and Yifan Yao and Kun Yang and Zebing Zeng}, doi = {10.1002/anie.202418520}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418520}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facile access to phosphorus ylide-fused heteroarenes possessing tunable optoelectronic properties and high nonlinear optical performances}, volume = {64}, year = {2025}, }
• (2025). Enabling interfacial lattice matching by selective epitaxial growth of CuS crystals on Bi2WO6 nanosheets for efficient CO2 photoreduction into solar fuels. ANGEW, 64(6), e202418496. (www)

  @article{ , abstract = {Photocatalytic CO 2 reduction serves as an important technology for value-added solar fuel production, however, it is generally limited by interfacial charge transport. To address this limitation, a two-dimensional/two-dimensional (2D/2D) p-n heterojunction CuS-Bi 2 WO 6 (CS-BWO) with highly connected and matched interfacial lattices was designed in this work via a two-step hydrothermal tandem synthesis strategy. The integration of CuS with BWO created a robust interface electric field and provided fast charge transfer channels due to the work function difference, as well as highly connected and matched interfacial lattices. The p-n heterojunction combination promoted the electron transfer from the Cu to Bi sites, leading to the coordination of Bi sites with high electronic density and low oxidation state. The Bi sites in the BWO nanosheets facilitated the adsorption and activation of CO 2 , and the generation of high-coverage key intermediate b-CO 3 2− , while CuS (CS) acted as a broad light-harvesting material to provide abundant photoinduced electrons that were injected into the conduction band of BWO for CO 2 photoreduction reaction. Remarkably, the p-n heterojunction CS-BWO exhibited average CO and CH 4 yields of 33.9 and 16.4 μmol g −1 h −1 , respectively, which were significantly higher than those of CS, BWO, and physical mixture CS-BWO samples. This work provided an innovative design strategy for developing high-activity heterojunction photocatalyst for converting CO 2 into value-added solar fuels.}, archive = {J_ANGEW}, author = {Jiaqi Tian and Yangyang Zhang and Zuhao Shi and Zhongyi Liu and Zaiwang Zhao and Jun Li and Neng Li and Hongwei Huang}, doi = {10.1002/anie.202418496}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enabling interfacial lattice matching by selective epitaxial growth of CuS crystals on Bi2WO6 nanosheets for efficient CO2 photoreduction into solar fuels}, volume = {64}, year = {2025}, }
• (2025). Borane-mediated highly secondary selective deoxyfluorination of alcohols. ANGEW, 64(6), e202418495. (www)

  @article{ , abstract = {Organofluorine compounds are vital across multiple sectors, hence highly selective methods to install fluorine are of considerable importance. The deoxyfluorination of alcohols is a key approach to prepare organofluorine compounds, however, a highly secondary (2°)-selective deoxyfluorination of alcohols has not been realized to date. Herein, we report that borane-mediated deoxyfluorination results in high 2°-selectivity in inter- and intra-molecular competition reactions versus primary (1°), tertiary (3°) and even benzylic (Bn) alcohols. This is an operationally simple method using only commercial reagents (e.g., Et 3 N ⋅ 3HF) that starts from the alcohol which is converted to the O -alkyl- N -H-isourea in situ. The origin of the high 2°-selectivity was elucidated to be due to the relative barriers to carbodiimide elimination from the O -alkyl- N -(BR 2 )-isoureas. As the selectivity controlling step does not involve fluoride, this borane-mediated approach can be applied to other nucleophiles, as demonstrated by 2°-selective deoxychlorination using HCl occurring in preference to substitution of 1° and Bn analogues. This borane-mediated nucleophilic substitution therefore provides a new approach to circumvent the selectivity limitations inherent in classical S N 2 and S N 1 type reactions.}, archive = {J_ANGEW}, author = {Dominic R. Willcox and Nojus Cironis and Laura Winfrey and Sven Kirschner and Gary S. Nichol and Stephen P. Thomas and Michael J. Ingleson}, doi = {10.1002/anie.202418495}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418495}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Borane-mediated highly secondary selective deoxyfluorination of alcohols}, volume = {64}, year = {2025}, }
• (2025). Chemoselective ring-opening polymerization of α-methylene-δ-valerolactone catalyzed by a simple organoaluminum complex to prepare closed-loop recyclable functional polyester. ANGEW, 64(6), e202418488. (www)

  @article{ , abstract = {α-Methylene-δ-valerolactone (MVL) as a bio-renewable bifunctional monomer has shown great promise to prepare closed-loop recyclable polyester with pendent functionalizable double bond. However, the chemoselective ring-opening polymerization (ROP) of MVL still faces challenges including low polymerization temperature, expensive catalyst as well as high catalyst loading. In this contribution, we present the chemoselective and controlled ROP of MVL using a simple organoaluminum complex [MeAl(BHT) 2 ] (BHT=2,6-di-tert-butyl-4-methylphenoxy), which can be easily prepared from commercially available trimethylaluminum and 2,6-di-tert-butyl-4-methylphenol without purification. MeAl(BHT) 2 exhibits much higher catalytic activity (TOF=668 h −1 ) than that of MeAl[Salen] (TOF=89 h −1 ), a commonly used organoaluminum catalyst. The high chemoselectivity and activity of MeAl(BHT) 2 is proposed to originate from the cooperative activation of propagating chain-ends and monomers via the “coordination-insertion” mechanism. Remarkably, high-molecular-weight P(MVL) ROP can be prepared in bulk using MeAl(BHT) 2 , which is not accessible by the previous catalysts. This study may advance the development of closed-loop recyclable polymers considering the easy preparation, low cost and good catalytic performance of MeAl(BHT) 2 .}, archive = {J_ANGEW}, author = {Qin Yan and Jiashu Ma and Weijie Pei and Yaxin Zhang and Ronglin Zhong and Shaofeng Liu and Yong Shen and Zhibo Li}, doi = {10.1002/anie.202418488}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemoselective ring-opening polymerization of α-methylene-δ-valerolactone catalyzed by a simple organoaluminum complex to prepare closed-loop recyclable functional polyester}, volume = {64}, year = {2025}, }
• (2025). Global profiling lysine reactivity and ligandability with oxidant-triggered bioconjugation chemistry. ANGEW, 64(6), e202418473. (www)

  @article{ , abstract = {Due to the high abundance and diverse functions of lysine residues, both in the interior and on the surface of proteins, the development of new methods to characterize their reactivity and ligandability could significantly expand the pool of druggable targets. To date, only a limited number of aminophilic electrophiles have been assessed for interactions with the lysine proteome, resulting in a substantial fraction remaining inaccessible to current probes. Here, to the best of our knowledge, we report the first oxidant-triggered bioconjugation platform for in-depth profiling of lysines. We quantified over 7000 covalently modifiable lysine residues, which significantly expands the coverage of ligandable lysines in the whole proteome. Chemical proteomics enabled the mapping of more than 100 endogenous kinases, thus providing a comprehensive landscape of ligandable catalytic lysines within the kinome. Moreover, we identified a suite of new ligandable lysines such as K60 of ENO1 and K31 of PPIA, offering insights for exploring new functional and targetable residues. These findings could provide valuable clues for the development of targeted covalent inhibitors (TCIs).}, archive = {J_ANGEW}, author = {Mengya Zhou and Shengrong Li and Yi Tan and Weizhen Huang and Yifang Li and Xia Yuan and Zhengqiu Li}, doi = {10.1002/anie.202418473}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418473}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Global profiling lysine reactivity and ligandability with oxidant-triggered bioconjugation chemistry}, volume = {64}, year = {2025}, }
• (2025). Quasi-single-crystal tin halide perovskite films with high structural integrity for near-infrared imaging array enabling hidden object recognition. ANGEW, 64(6), e202418470. (www)

  @article{ , abstract = {Near-infrared (NIR) image sensors based on solution-processed thin film are gaining prominence in various applications, including security detection, remote sensing, medical imaging, and environmental monitoring, owing to superior penetration capabilities of NIR light. However, the reported perovskite image sensors suffer from limited resolution and performance due to poor structural integrity, bioincompatibility, and constrained response wavelength range from lead-based perovskite materials employed. In this study, we present non-toxic quasi-single-crystal (QSC) CH(NH 2 ) 2 SnI 3 (FASnI 3 ) perovskite films, prepared via a simple spin-coating technique, that demonstrate high structural integrity and effective NIR response. Through a series of in situ characterizations, we reveal that the orderly growth mode of QSC-FASnI 3 perovskite films enables a more oriented crystal growth with reduced trap and grain boundaries. Consequently, self-powered NIR photodetector based on QSC-FASnI 3 films exhibited large detectivity over 10 13 Jones in the NIR range (780–890 nm). Ultimately, due to the high structural integrity, the high-resolution 64×64 (4096) pixels NIR imaging array, exhibiting reduced photo and dark response non-uniformity value, was fabricated on the thin-film transistors (TFT) backplanes, enabling ultraweak NIR light (63 nW cm −2 ) real-time imaging, fingerprint imaging, and hidden object recognition. This work pioneers the application of lead-free perovskite for high-resolution NIR imaging arrays.}, archive = {J_ANGEW}, author = {Tianhua Liu and Lixia Wang and Ziquan Yuan and Junfang Wang and Junjie Huang and Weitong Wu and Xiangyue Meng}, doi = {10.1002/anie.202418470}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418470}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quasi-single-crystal tin halide perovskite films with high structural integrity for near-infrared imaging array enabling hidden object recognition}, volume = {64}, year = {2025}, }
• (2025). Regulating interfacial hydrogen-bonding networks by implanting cu sites with perfluorooctane to accelerate CO2 electroreduction to ethanol. ANGEW, 64(6), e202418459. (www)

  @article{ , abstract = {Efficient CO 2 electroreduction (CO 2 RR) to ethanol holds promise to generate value-added chemicals and harness renewable energy simultaneously. Yet, it remains an ongoing challenge due to the competition with thermodynamically more preferred ethylene production. Herein, we presented a CO 2 reduction predilection switch from ethylene to ethanol (ethanol-to-ethylene ratio of ~5.4) by inherently implanting Cu sites with perfluorooctane to create interfacial noncovalent interactions. The 1.83 %F-Cu 2 O organic–inorganic hybrids (OIHs) exhibited an extraordinary ethanol faradaic efficiency (FE ethanol ) of ∼55.2 %, with an impressive ethanol partial current density of 166 mA cm −2 and excellent robustness over 60 hours of continuous operation. This exceptional performance ranks our 1.83 %F-Cu 2 O OIHs among the best-performing ethanol-oriented CO 2 RR electrocatalysts. Our findings identified that C 8 F 18 could strengthen the interfacial hydrogen bonding connectivity, which consequently promotes the generation of active hydrogen species and preferentially favors the hydrogenation of *CHCOH to *CHCHOH, thus switching the reaction from ethylene-preferred to ethanol-oriented. The presented investigations highlight opportunities for using noncovalent interactions to tune the selectivity of CO 2 electroreduction to ethanol, bringing it closer to practical implementation requirements.}, archive = {J_ANGEW}, author = {Jing Zhou and Bingling He and Pu Huang and Dongge Wang and Zechao Zhuang and Jing Xu and Chengsi Pan and Yuming Dong and Dingsheng Wang and Yao Wang and Hongwen Huang and Jiawei Zhang and Yongfa Zhu}, doi = {10.1002/anie.202418459}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating interfacial hydrogen-bonding networks by implanting cu sites with perfluorooctane to accelerate CO2 electroreduction to ethanol}, volume = {64}, year = {2025}, }
• (2025). Strontium doped IrOx triggers direct O−O coupling to boost acid water oxidation electrocatalysis. ANGEW, 64(6), e202418456. (www)

  @article{ , abstract = {The discovery of efficient and stable electrocatalysts for the oxygen evolution reaction (OER) in acidic conditions is crucial for the commercialization of proton-exchange membrane water electrolyzers. In this work, we propose a Sr(OH) 2 -assisted method to fabricate a (200) facet highly exposed strontium-doped IrO x catalyst to provide available adjacent iridium sites with lower Ir−O covalency. This design facilitates direct O−O coupling during the acidic water oxidation process, thereby circumventing the high energy barrier associated with the generation of *OOH intermediates. Benefiting from this advantage, the resulting Sr−IrO x catalyst exhibits an impressive overpotential of 207 mV at a current density of 10 mA cm −2 in 0.5 M H 2 SO 4 . Furthermore, a PEMWE device utilizing Sr−IrO x as the anodic catalyst demonstrates a cell voltage of 1.72 V at 1 A cm −2 and maintains excellent stability for over 500 hours. Our work not only provides guidance for the design of improved acidic OER catalysts but also encourages the development of iridium-based electrocatalysts with novel mechanisms for other electrocatalytic reactions.}, archive = {J_ANGEW}, author = {Wuyong Zhang and Caihan Zhu and Yingjie Wen and Minli Wang and Zhiyi Lu and Yunan Wang}, doi = {10.1002/anie.202418456}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strontium doped IrOx triggers direct O−O coupling to boost acid water oxidation electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Deep neural network enhanced mesoscopic thermodynamic model for unlocking the Electrode/Electrolyte interface. ANGEW, 64(6), e202418447. (www)

  @article{ , abstract = {Structure and properties of the electrode/electrolyte interface significantly influence the electrochemical processes of energy storage and conversion, yet the challenge lies in accurate description of both molecular characteristics and external field effects. Here, we develop a mesoscopic thermodynamic model that calculates the thermodynamic properties of electrolytes based on chemical potential, and its efficiency is enhanced by a deep neural network. The deep neural network enhanced mesoscopic thermodynamic (DeepMT) model effectively bridges the gap between micro-level characteristics of ions and macro-level effects of external field, enabling precise presentation of ion density distributions over complex conditions. Our result indicates that the DeepMT model not only demonstrates a computational efficiency improvement of approximately four orders of magnitude over direct theoretical calculations, but also accurately predicts interface properties including ion adsorption, surface charge, and differential capacitance through the statistical analysis of density distributions.}, archive = {J_ANGEW}, author = {Haolan Tao and Sijie Wang and Honglai Liu and Cheng Lian}, doi = {10.1002/anie.202418447}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418447}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deep neural network enhanced mesoscopic thermodynamic model for unlocking the Electrode/Electrolyte interface}, volume = {64}, year = {2025}, }
• (2025). Local structure-induced selective interactions enables high-performance and burn-in-free organic photovoltaics. ANGEW, 64(6), e202418439. (www)

  @article{ , abstract = {Oligomeric acceptors (OAs) have attracted considerable attention in the organic photovoltaics (OPV) field owing to their capacity in balancing the merits from both monomeric and polymeric acceptors. A delicate control over the distortion between blocks of OAs usually determines the performance and stability of relevant OPV devices. However, it imposes great complexity to realize a controllable degree of distortion by tuning the skeleton of blocks and the position of linker between blocks. Herein, we developed a facile strategy to rationally control the geometry distortion of OAs via a straightforward substitution of alkoxy side-chains on their blocks. This helps elucidate the integrated influences of molecular distortion and non-bonded contacts on the selective interactions between OA molecules and between OA and host acceptor in ternary blend. We demonstrate the alkoxy-OA molecules having stronger self-interactions would mitigate their interactions with host acceptor, therefore alleviating the kinetic diffusion and excessive aggregation of total acceptors. Combining with a composite-interlayer strategy by introducing a phenyl-substituted self-assembled monolayer to enhance the doping with polyoxometalate, an impressive efficiency of 20.1 % is achieved accompanied by a negligible burn-in loss against physical aging. This study demonstrates the validation of tuning of selective interactions towards high-performance and burn-in-free OPV.}, archive = {J_ANGEW}, author = {Baobing Fan and Huanhuan Gao and Liyang Yu and Ruipeng Li and Lei Wang and Wenkai Zhong and Yunfan Wang and Wenlin Jiang and Huiting Fu and Tianqi Chen and Bin Kan and Sai-Wing Tsang and Alex K.-Y. Jen}, doi = {10.1002/anie.202418439}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418439}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Local structure-induced selective interactions enables high-performance and burn-in-free organic photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Facilitating rapid OH−/H2O transport in anion exchange membranes via ultra-stable heteroatom-free micropores. ANGEW, 64(6), e202418435. (www)

  @article{ , abstract = {Efficient OH − conduction in anion exchange membranes (AEMs) is pivotal for the advancement and industrialization of sustainable electrochemical technologies in alkaline environments, including water electrolysis, fuel cells, and CO 2 electroreduction. We here designed AEMs with a novel class of rigid heteroatom-free micropores (HFMs), engineered at the molecular level to facilitate rapid ionic transport in an ultra-stable manner. By manipulating monomers, our design strategically controls the torsional angles and energy barriers within the polymeric backbones, creating sub-nanometer ionic channels that precisely regulate porosity. These hydrophilic micropores significantly enhance the mobility of OH − /H 2 O, achieving over a 150 % increase in self-diffusion coefficient compared to commercial AEMs and elevating OH − conductivity to a leading 215 mS cm −1 at 80 °C. Moreover, the robust carbon-carbon bond construction in HFMs offers the stability that is four orders of magnitude higher under severe alkaline conditions compared to existing wisdoms, with a demonstrated operational lifespan of over 4000 hours. The integration of HFM-AEMs into water electrolyzers not only supports the use of platinum group metal-free catalysts but also exhibits exceptional energy efficiency and extended durability, highlighting their substantial potential for wide-ranging applications in emerging electrochemical technologies.}, archive = {J_ANGEW}, author = {Maobin Pang and Ziang Xu and Dongcheng Lin and Yihan Zhen and Jiekang Tian and Jing Liu and Qin Xu and Baoguo Wang}, doi = {10.1002/anie.202418435}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418435}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facilitating rapid OH−/H2O transport in anion exchange membranes via ultra-stable heteroatom-free micropores}, volume = {64}, year = {2025}, }
• (2025). Electrostatic confinement-induced excited charge transfer in ionic covalent organic framework promoting CO2 reduction. ANGEW, 64(6), e202418422. (www)

  @article{ , abstract = {We demonstrate an electrostatic confinement-induced charge transfer pathway in a supramolecular photocatalyst comprising of an ionic covalent organic framework (COF) and cationic metal complexes. The dynamic electrostatic interactions not only attract cations around the COF to accept photogenerated electrons, but also allow for a retention of homogeneous catalytic characters of complexes, making a subtle balance. Accordingly, the electrostatic confinement effect facilitates the forward electron transfer from a photoexcited COF to cationic Co complex, realizing a remarkable photocatalytic CO 2 reduction performance. Its catalytic efficiency is far superior to the supramolecular counterparts with Van-der-Waals or hydrogen bonding interactions. This work presents an insight for enhancing charge transfer in supramolecular systems, and provides an effective approach for construction of highly efficient photocatalysts.}, archive = {J_ANGEW}, author = {Mingfei Yu and Wei Chen and Qingqing Lin and Liuyi Li and Zheyuan Liu and Jinhong Bi and Yan Yu}, doi = {10.1002/anie.202418422}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418422}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrostatic confinement-induced excited charge transfer in ionic covalent organic framework promoting CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Scalable, high-yield monolayer MXene preparation from multilayer MXene for many applications. ANGEW, 64(6), e202418420. (www)

  @article{ , abstract = {MXene (Ti 3 C 2 T x ) is renowned for its exceptional conductivity and hydrophilicity; however, the low yield of monolayers hinders its industrial scalability. Herein, we present a strategy to substantially enhance the monolayer yield by disrupting the hydrogen-bonding cage confinement of multilayer MXene using high-temperature ultrasound, challenging the conventional belief that monolayer MXene can only be prepared at lower temperatures. At approximately 70 °C, the weakened hydrogen bonding between the oxygen-containing terminal groups of multilayer MXene and surrounding water molecules weakens the hydrogen-bond cage confinement. This enables ultrasonic cavitation to generate more microbubbles that penetrate the interlayers of multilayer MXene, resulting in gentle and thorough delamination into larger monolayer nanosheets. Achieving up to a 95 % yield in just tens of minutes, these nanosheets exhibit properties comparable to those produced by traditional ice-bath methods. Furthermore, the high-concentration MXene ink produced on a large scale using this high-yield approach exhibits excellent printing and processing capabilities, and the corresponding products showcase superior infrared stealth and Joule heating characteristics. This work addresses a key technical bottleneck in MXene production, paving the way for its extensive technological and industrial applications.}, archive = {J_ANGEW}, author = {Xiangxiang Shi and Zhen Yu and Zi Liu and Ningning Cao and Lin Zhu and Yuyan Liu and Ke Zhao and Ting Shi and Liang Yin and Zhimin Fan}, doi = {10.1002/anie.202418420}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418420}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable, high-yield monolayer MXene preparation from multilayer MXene for many applications}, volume = {64}, year = {2025}, }
• (2025). Flux synthesis of robust polyimide covalent organic frameworks with high-density redox sites for efficient proton batteries. ANGEW, 64(6), e202418394. (www)

  @article{ , abstract = {Aqueous proton batteries are attracting increasing attention in the large-scale next-generation energy storage field. However, the electrode materials for proton batteries often suffer from low specific capacity and unsatisfactory cycle durability. Herein, we synthesize two highly crystalline and robust polyimide covalent organic frameworks (COFs) through a solvent-free flux synthesis approach with benzoic acid as a flux and catalyst. The as-synthesized COFs possess enriched redox-active sites for proton storage and intrinsic Grotthuss proton conduction, rendering them ideal candidates for proton electrode materials. The optimal COF electrodes achieve a high specific capacity of 180 mAh/g at 0.1 A/g, among the highest COF-based proton batteries, and exhibit an outstanding rate capability of up to 100 A/g and long-term cycling stability with capacity retention of 99 % after 5000 cycles at 5 A/g. The assembled full cells deliver a specific capacity of 150 mAh/g at 0.2 A/g with a maximum energy density of 72 Wh/kg and a maximum supercapacitor-level power density of 64 kW/kg, surpassing all reported COF-based systems. This work paves a new avenue for the design of electrode materials for aqueous proton batteries with high energy density, power density, rate capability and long-term cycling stability.}, archive = {J_ANGEW}, author = {Yi Yang and Sa Wang and Yuqing Duan and Ting Wang and Fengdong Wang and Haitao Zhu and Zhifang Wang and Kai Zhang and Peng Cheng and Zhenjie Zhang}, doi = {10.1002/anie.202418394}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418394}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flux synthesis of robust polyimide covalent organic frameworks with high-density redox sites for efficient proton batteries}, volume = {64}, year = {2025}, }
• (2025). Skeletal nitrogen functionalization of isostructural 2D conjugated MOFs for enhancement of the dual-ion storage capacity. ANGEW, 64(6), e202418390. (www)

  @article{ , abstract = {Two-dimensional conjugated metal–organic frameworks (2D c -MOFs) are emerging as promising electrode materials for electrochemical energy storage devices. However, a viable path to realize superior dual-ion storage in 2D c -MOFs has remained elusive. Here, we report the synthesis of Cu 2 (N x −OHPTP) 2D c -MOFs ( x =0,1,2; OHPTP=octahydroxyphenanthrotriphenylene) with precise aromatic carbon-nitrogen arrangements, based on the π-conjugated OHPTP ligand incorporated with one or two nitrogen atoms. The skeletal nitrogen modification in Cu 2 (N x −OHPTP) allows the synergistic introduction of additional redox sites, and thus substantially favors the unique dual-ion adsorption capacity. Consequently, the Cu 2 (N 2 −OHPTP) cathode exhibits a largely enhanced electrochemical performance for dual-ion storage (i.e., Li + and Cl - ) with a high specific capacity of 53.8 mAh g −1 , which is twice that of Cu 2 (N 0 −OHPTP) and 1.3 times that of Cu 2 (N 1 −OHPTP). Furthermore, the Cu 2 (N 2 −OHPTP) electrode displays a favorable rate performance of 52 % and good cycling stability of 96 % after 1000 cycles. We identify N-centered redox sites as additional Li + adsorption sites by combining ex situ and in situ spectroscopy measurements and theoretical calculations. In addition, calculations underline the synergistic enhancement of the Cl − adsorption energy by about 1.0 eV at the more electron-poor CuO 4 linkages after N-incorporation. This work paves the way for the precise design of 2D c -MOFs with superior electrochemical properties, advancing their application in dual-ion storage applications.}, archive = {J_ANGEW}, author = {Lukas Sporrer and Quanquan Guo and Xiaodong Li and Angelika Wrzesinska-Lashkova and Fanny Reichmayr and Shuai Fu and Hai I. Wang and Mischa Bonn and Xiangyu Li and Paul-Alexander Laval-Schmidt and Mingchao Wang and Yang Lu and Yana Vaynzof and Minghao Yu and Xinliang Feng and Renhao Dong}, doi = {10.1002/anie.202418390}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Skeletal nitrogen functionalization of isostructural 2D conjugated MOFs for enhancement of the dual-ion storage capacity}, volume = {64}, year = {2025}, }
• (2025). Shielding fluoride ion basicity through diurea coordination for nonaqueous fluoride shuttle batteries. ANGEW, 64(6), e202418371. (www)

  @article{ , abstract = {The strong basicity of fluoride ions leads to detrimental nucleophilic attack on organic components in the electrolytes, such as β-hydrogen elimination reactions with organic cations and solvents, converting “naked” F − into corrosive and unstable bifluoride (HF 2 − ) ions. These reactions significantly constrain the choice of suitable solvents and salts to develop electro(chemical) stable fluoride ion electrolytes. In this work, we replaced the triple water ligands typically present in industrial organic fluoride salts with dual 1,3-diphenylurea (DPU) coordination via hydrogen bonding interaction. This modification successfully suppressed the Lewis basicity of fluoride ions, providing long-term chemical stability (over 1000 hours) across a wide range of aprotic solvents, a broadened electrochemical stability window (−2.5–0.9 V vs. Ag + /Ag) and high ionic conductivity (1.7 mS cm −1 ) at room temperature. Additionally, the weaker hydrogen bonding in F − -DPU coordination, compared to the conventional boron-based anion acceptor (AA) strategy that relies on intensive Lewis acid-base interactions, facilitates faster (de)fluorination kinetics at the electrode. The proposed room temperature fluoride ion batteries sustain improved electrochemical performance by pairing with the Pb-PbF 2 anode and BiF 3 or Ag cathode.}, archive = {J_ANGEW}, author = {Huijian Wang and Chengjun Lei and Tingting Liu and Ruijin Meng and Xiao Liang}, doi = {10.1002/anie.202418371}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418371}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Shielding fluoride ion basicity through diurea coordination for nonaqueous fluoride shuttle batteries}, volume = {64}, year = {2025}, }
• (2025). Switchable radical polymerization of α-olefins via remote hydrogen atom or group transfer for enhanced battery performance. ANGEW, 64(6), e202418350. (www)

  @article{ , abstract = {Introducing polar groups into non-polar polyolefins can significantly enhance the important properties of materials. However, producing polyolefin backbones consisting of polar blocks remains elusive, due to the substantial difference of reactivity ratios between polar and non-polar olefin monomers in radical polymerization or the poisoning of transition-metal catalysts by polar groups in coordination polymerization. Herein we present a practical way for the preparation of polyethylene-based polymers with distinct polar groups by radical polymerization of α -olefins. A strategy of switchable remote hydrogen atom or group transfer is devised, leading to a diverse range of AAB or ABC sequence-defined carbon-chain polyolefins. The utility of these polymers is demonstrated by using poly(ethyl 2-cyanohept-6-enoate) ( P2 ) as an interphase layer material in anode-free Li metal battery, which effectively improves the cycling stability of the battery and indicates its potential in energy storage applications.}, archive = {J_ANGEW}, author = {Silin Song and Shuo Wang and Ziqiang Wang and Hao Sun and Xianjin Wang and Chen Zhu}, doi = {10.1002/anie.202418350}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switchable radical polymerization of α-olefins via remote hydrogen atom or group transfer for enhanced battery performance}, volume = {64}, year = {2025}, }
• (2025). CdWO4 sub-1 nm nanowires for visible-light CO2 photoreduction. ANGEW, 64(6), e202418349. (www)

  @article{ , abstract = {Quantum size effect usually causes energy level splitting and band broadening as material size decreases. However, this may change again by the surface adsorbents, doping and defects, which rarely attracts much attention. Herein, CdWO 4 sub-1 nm nanowires (SNWs) with oleylamine adsorption, PO 4 3− -doping and oxygen defects are synthesized by combining Cd(CH 3 COO) 2 , H 3 PW 12 O 40 (PW 12 ) and oleylamine (abbreviated as PO 4 3− -CdWO 4 -X SNWs ). Compared with bulk CdWO 4 , they exhibit unexpected absorption spectra (extended from 292 nm to 453 nm) and band gap (reduced from 4.25 e V to 2.74 e V), thus bringing remarkable visible-light CO 2 photoreduction activity. Under 410 nm LED light irradiation, PO 4 3− -CdWO 4 -40 SNWs exhibit the highest photocatalytic performance with a CO 2 -to-CO generation rate of 1685 μmol g −1 h −1 . Density functional theory (DFT) calculations demonstrate the adsorbed oleylamine raises the valence band and enhances the adsorption of reaction substrate and intermediates, thus decreasing their reduction energy barriers. Furthermore, PO 4 3− -doping and oxygen defects will generate defect energy band below the conduction band of PO 4 3− -CdWO 4 -40 SNWs , resulting in remarkable visible light absorption and superior photocatalytic CO 2 reduction performance. This work highlights the significant impacts of surface adsorbents, doping and defects on the physicochemical and catalytic properties of sub-nano materials.}, archive = {J_ANGEW}, author = {Yan-Chun Liu and Chang-Yan Zhu and Xia Zhao and Hua-Qiao Tan and Si-Hang Cheng and Dan Yang and Xun Wang and Yang-Guang Li}, doi = {10.1002/anie.202418349}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418349}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CdWO4 sub-1 nm nanowires for visible-light CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Synergistic π-extension and peripheral-locking of B/N-based multi-resonance framework enables high-performance pure-green organic light-emitting diodes. ANGEW, 64(6), e202418348. (www)

  @article{ , abstract = {Multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters offer natural advantages for creating power-efficient, wide-color-gamut OLEDs. However, current green MR-TADF emitters face challenges in simultaneously achieving high color purity and efficient reverse inter-system crossing (RISC), leading to suboptimal device performance. In this study, we propose a synergistic molecular design approach that combines π-extension and peripheral locking to address these challenges. This approach allows for the construction of quadruple borylated MR-TADF emitters that not only deliver precisely tuned pure-green emission with a narrow full width at half maximum (FWHM) of 15 nm, but also exhibit close-to-unity quantum yield, rapid RISC, and optimal horizontal dipole orientation. The resulting sensitizer-free OLED approaches the BT.2020 standard with CIE coordinates of (0.18, 0.74) and demonstrates impressive external quantum efficiency (EQE) of 36.6 % at maximum and 31.8 % at 1000 cd m −2 . Additionally, the device shows good operational stability, with a lifetime (LT 80 ) of 485 hours at an initial luminance of 1000 cd m −2 . This study hence offers a promising molecular design strategy that effectively enhances the comprehensive OLED performance.}, archive = {J_ANGEW}, author = {Shengbing Xiao and Xiaosong Cao and Guohao Chen and Xiaojun Yin and Zhi Chen and Jingsheng Miao and Chuluo Yang}, doi = {10.1002/anie.202418348}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic π-extension and peripheral-locking of B/N-based multi-resonance framework enables high-performance pure-green organic light-emitting diodes}, volume = {64}, year = {2025}, }
• (2025). Atomic infusion induced reconstruction enhances multifunctional thermally conductive films for robust low-frequency electromagnetic absorption. ANGEW, 64(6), e202418338. (www)

  @article{ , abstract = {Deterministic fabrication of highly thermally conductive composite film with satisfying low-frequency electromagnetic (EM) absorption performance exhibits great potential in advancing the application of 5G smart electric devices but persists challenge. Herein, a multifunctional flexible film combined with hetero-structured Fe 6 W 6 C-FeWO 4 @C (FWC−O@C) as the absorber and aramid nanofibers (ANFs) as the matrix was prepared. Driven by an atomic gradient infusion reduction strategy, the carbon atoms of absorbers can be precisely relocated from carbon shell to core oxometallate lattice, triggering in situ carbothermic reduction for customization of unique oxometallate-carbide heterojunctions and surface geometrical structure. Such an atoms reconstruction process effectively regulates interface electronic structure and magnetic configuration, resulting in enhanced polarization loss from abundant heterointerfaces and crystal defects and magnetic loss from hierarchical structure endowed magnetic coupling interaction, which jointly contributes to the efficient low-frequency EM absorption performance. Eventually, optimized FWC−O@C microplate exhibits a broad absorption bandwidth surpassed the entire C band, and the assembled FWC−O@C/ANFs composite film also performs a high thermal conductivity over 2500 % higher than that of the pure ANFs. These findings provide a new insight into the atomic reconstruction affected EM properties and a generalized methodological guidance for preparing multifunctional thermally conductive composite films.}, archive = {J_ANGEW}, author = {Longjun Rao and Mengqiu Huang and Xinglong Wang and Yuetong Qian and Zhikai Yan and Lei Wang and Qingqing Li and Renchao Che}, doi = {10.1002/anie.202418338}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418338}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomic infusion induced reconstruction enhances multifunctional thermally conductive films for robust low-frequency electromagnetic absorption}, volume = {64}, year = {2025}, }
• (2025). Synthesis and characterizations of dibenzo-fused perioctacene. ANGEW, 64(6), e202418334. (www)

  @article{ , abstract = {Dibenzoperioctacene (DBPO) with extended zigzag edges was synthesized and unambiguously characterized by a combination of nuclear magnetic resonance (NMR), mass spectrometry, and single-crystal X-ray diffraction analysis. Variable-temperature (VT) NMR analysis indicated the closed-shell character of DBPO, yet the bond lengths in the single-crystal structure of DBPO aligned more closely with those of open-shell teranthene than closed-shell bisanthene. Spin-unrestricted density functional theory (DFT) calculations using various methods supported that ground state of DBPO might be on the borderline between closed- and open-shell singlet states, with a large singlet-triplet energy gap ( ΔE ST ), consistent with the VT NMR and bond-length analyses. UV/Vis-near infrared (NIR) absorption spectrum showed the longest-wavelength peak at 905 nm, marking the NIR optical properties of DBPO. DBPO exhibited a tendency to react with atmospheric oxygen, which additionally hinted at its possible open-shell character. Furthermore, the oxidized species of non-fluorescent DBPO exhibited strong emission at 820 and 915 nm.}, archive = {J_ANGEW}, author = {Xiushang Xu and Liliia Moshniaha and Serhii Vasylevskyi and Ryota Kabe and Tatsuhiko Ohto and Akimitsu Narita}, doi = {10.1002/anie.202418334}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418334}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and characterizations of dibenzo-fused perioctacene}, volume = {64}, year = {2025}, }
• (2025). Chemical O-ADP-ribosylations: Synthesis and bioconjugation of ADPr-Peptides/Proteins from NAD+. ANGEW, 64(6), e202418321. (www)

  @article{ , abstract = {ADP-ribosylation is a complex post-translational modification involved in key physiological processes and associated with various health and disease states. The growing interest in ADP-ribosylation necessitates straightforward and efficient synthetic methods for the preparation of ADP-ribosylated peptides/proteins. In this study, we report a facile reaction between nicotinamide adenine dinucleotide (NAD + ) and alcohols promoted by a combination of ionic liquids, yielding up to 94 % with α : β ratios ranging from 88 : 12 to 99 : 1 and a switchable configuration selectivity. This method significantly simplifies the production of ADP-ribosylated peptides and proteins, enabling diverse applications. It allows detailed investigation of side-chain structure–activity relationships, facilitates two-step clickable conjugation of ADP-ribosyl groups to proteins, and, for the first time, enables non-enzymatic synthesis of well-defined ADP-ribosylated peptides/proteins from natural counterparts and NAD + .}, archive = {J_ANGEW}, author = {Yanbo You and Anlian Zhu and Dongshuang Fan and Honglei Wang and Lingjun Li}, doi = {10.1002/anie.202418321}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418321}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical O-ADP-ribosylations: Synthesis and bioconjugation of ADPr-Peptides/Proteins from NAD+}, volume = {64}, year = {2025}, }
• (2025). Induced charge-compensation effect for boosting photocatalytic water splitting in covalent organic frameworks. ANGEW, 64(6), e202418319. (www)

  @article{ , abstract = {Imine-based covalent organic frameworks (COFs) are promising for photocatalytic water splitting, but their performance is often constrained by inefficient charge separation due to the high electron localization nature of polar imine bonds. In this study, we have optimized the electron delocalization across the imine linkage within a COF by implementing a charge compensation effect. This effect is achieved when a strong electron-donating thieno[3,2-b]thiophene linker is directly attached to the iminic carbon of a zinc-porphyrinic COF. This modification significantly reduces the electron binding effect within the imine bonds of the COF, facilitating both in-plane charge separation and out-plane charge transfer to the catalytic site. Conversely, the use of strong electron-withdrawing pyrizine linker aggravates the electron localization at the imine linkage in the ZnP−Pz variant. Consequently, ZnP−Tt shows a substantially improved photocatalytic water-splitting activity under visible light irradiation, with a hydrogen evolution of 44288±2280 μmol g −1 in 4 h, which exceeds the ZnP−Pz counterpart by a factor of 10. These results offer fresh perspectives for the design of imine-based COFs to overcome their limitations in charge separation efficiency.}, archive = {J_ANGEW}, author = {Lei Zou and Duanhui Si and Shuailong Yang and Ziao Chen and Yuanbiao Huang and Rong Cao}, doi = {10.1002/anie.202418319}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418319}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Induced charge-compensation effect for boosting photocatalytic water splitting in covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Expedited SARS-CoV-2 main protease inhibitor discovery through modular ‘Direct-to-biology’ screening. ANGEW, 64(6), e202418314. (www)

  @article{ , abstract = {Reactive fragment (RF) screening has emerged as an efficient method for ligand discovery across the proteome, irrespective of a target's perceived tractability. To date, however, the efficiency of subsequent optimisation campaigns has largely been low-throughput, constrained by the need for synthesis and purification of target compounds. We report an efficient platform for ‘direct-to-biology’ (D2B) screening of cysteine-targeting chloroacetamide RFs, wherein synthesis is performed in 384-well plates allowing direct assessment in downstream biological assays without purification. Here, the developed platform was used to optimise inhibitors of SARS-CoV-2 main protease (M Pro ), an established drug target for the treatment of COVID-19. An initial RF hit was developed into a series of potent inhibitors, and further exploration using D2B screening enabled a ‘switch’ to a reversible inhibitor series. This example of ligand discovery for M Pro illustrates the acceleration that D2B chemistry can offer for optimising RFs towards covalent inhibitor candidates, as well as providing future impetus to explore the evolution of RFs into non-covalent ligands.}, archive = {J_ANGEW}, author = {Harry Wilders and George Biggs and Sam M. Rowe and Emma E. Cawood and Ioannis G. Riziotis and Alan R. Rendina and Emma K. Grant and Jonathan Pettinger and David J. Fallon and Mark Skehel and David House and Nicholas C. O. Tomkinson and Jacob T. Bush}, doi = {10.1002/anie.202418314}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expedited SARS-CoV-2 main protease inhibitor discovery through modular ‘Direct-to-biology’ screening}, volume = {64}, year = {2025}, }
• (2025). On the stability of metastable monomers to bias the supramolecular polymerization of naphthalendiimides. ANGEW, 64(6), e202418301. (www)

  @article{ , abstract = {Herein, we report the synthesis of the naphthalendiimides (NDIs) 1 – 3 endowed with peripheral 3,4,5-trialkoxybenzamide units and a variable number of 1,2,3-triazole rings. Both the benzamide units and the triazole rings are able to form six- or seven-membered intramolecularly H-bonded pseudocycles that behave as metastable monomeric units. Whilst freshly prepared solutions of 1 – 3 afford H-type aggregates, the presence or lack of the 1,2,3-triazole rings strongly conditions the kinetics and stability of the resulting aggregated species. These structural features result in highly stable metastable monomeric species M * for the symmetric 2 that can be trapped for long periods of time when the sample is subject to a heating/cooling cycle. Contrary to NDI 2 , the M * species formed by 1 and 3 evolve to the final supramolecular polymers in shorter times. A detailed experimental and theoretical study display the different non-covalent supramolecular forces operating in the stabilization of such M * species. In all cases, but especially in those NDIs endowed with the triazoles rings (NDIs 2 and 3 ), a number of conformers for the metastable monomeric units can be modelled. The high stability of such monomeric species justifies the delay in the formation of the H-type aggregates.}, archive = {J_ANGEW}, author = {Francisco Rey-Tarrío and Luis Sánchez}, doi = {10.1002/anie.202418301}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418301}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On the stability of metastable monomers to bias the supramolecular polymerization of naphthalendiimides}, volume = {64}, year = {2025}, }
• (2025). Crafting molecular tools for 15-lipoxygenase-1 in a single step. ANGEW, 64(6), e202418291. (www)

  @article{ , abstract = {Small molecule modulators are powerful tools for selectively probing and manipulating proteins in native biological systems. However, the development of versatile modulators that exhibit desired properties is hindered by the lack of a rapid and robust synthetic strategy. Here, we develop a facile and reliable one-step methodology for the generation of multifunctional toolboxes encompassing a wide variety of chemical modulators with different desired features. These modulators bind irreversibly to the protein target via a selective warhead. Key elements are introduced onto the warhead in a single step using multi-component reactions. To illustrate the power of this new technology, we synthesized a library of diverse modulators designed to explore a highly challenging and poorly understood protein, human 15-lipoxygenase-1. Modulators made include; activity-based/photoaffinity probes, chemosensors, photocrosslinkers, as well as light-controlled and high-affinity inhibitors. The efficacy of our compounds was successfully established through the provision of on demand inhibition and labeling of our target protein in vitro , in cellulo and in vivo ; thus, proving that this technology has promising potential for applications in many complex biological systems.}, archive = {J_ANGEW}, author = {Anastasia Louka and Ntaniela Spacho and Dimitris Korovesis and Konstantinos Adamis and Christos Papadopoulos and Eirini-Eleni Kalaitzaki and Nektarios Tavernarakis and Constantinos G. Neochoritis and Nikolaos Eleftheriadis}, doi = {10.1002/anie.202418291}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418291}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crafting molecular tools for 15-lipoxygenase-1 in a single step}, volume = {64}, year = {2025}, }
• (2025). Paired electro-synthesis of remote amino alcohols with/in H2O. ANGEW, 64(6), e202418277. (www)

  @article{ , abstract = {Amino alcohols, particularly remote amino alcohols and peptide alcohols, are valuable due to their functional diversity in biologically active compounds. However, traditional synthesis methods face significant challenges, making electrochemistry an attractive alternative. We have developed a mild and biocompatible sequential paired electrolysis strategy, leveraging copper-electrocatalysis to synthesize diverse remote amino alcohols, including unnatural peptide alcohols. Both experimental results and density functional theory (DFT) calculations demonstrated that water serves as both the hydroxyl source and the solvent, facilitating the generation of CuH with Cu(I) at the cathode, which in turn reduces the aldehyde intermediates formed during the reaction.}, archive = {J_ANGEW}, author = {Xinyue Fang and Xinwei Hu and Quan-Xin Li and Shao-Fei Ni and Zhixiong Ruan}, doi = {10.1002/anie.202418277}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418277}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Paired electro-synthesis of remote amino alcohols with/in H2O}, volume = {64}, year = {2025}, }
• (2025). Dual Zn5−NiS4 sites in a redox-active Metal–Organic framework enables efficient cascade catalysis for nitrate-to-ammonia conversion. ANGEW, 64(6), e202418272. (www)

  @article{ , abstract = {Electrocatalytic Nitrate Reduction to Ammonia (NO 3 RR) offers a promising solution to both environmental pollution and the sustainable energy conversion. Here we propose an efficient cascade catalytic mechanism based on a dual Zn 5 −NiS 4 sites, orderly assembled in a redox-active metal–organic framework structure, which separately promotes the reaction kinetics of nitrate-to-nitrite and nitrite-to-ammonia conversions. Specifically, the Zn 5 clusters adsorb and selectively reduce the NO 3 − to NO 2 − , whereas [NiS 4 ] acts as an analogue to the ferredoxins, subsequently boosts the reduction of NO 2 − to produce NH 3 . To this end, the bimetallic Zn 5 −NiS 4 TP MOF was synthesized based on the redox-active ligand [Ni(C 2 S 2 (TPCOOH) 2 ) 2 ]. A maximum ammonia production rate of 23477.59 μg ⋅ h −1 ⋅ mg −1 cat. and faradaic efficiency 92.87 % was achived by Zn 5 −NiS 4 TP MOF under neutral conditions. To validate the critical role of dual Zn 5 −NiS 4 sites, Mn 5 −NiS 4 TP and Cd 2 −NiS 4 TP were synthesized as control samples, together with Zn-TTFTB, Zn−NiS 4 Ph and other Zn 5 -cluster-based MOFs applied for the investigation of electrocatalytic nitrate reduction. Our results indicated that substitution by -thienyl instead of -phenyl group increases the S-heteroatom content, improves the conductivity and facilitates electron transfer. Furthermore, Density Functional Theory (DFT) calculations of the energy changes for the reduction of each species could rationalize experimental results.}, archive = {J_ANGEW}, author = {Zedong Zhang and Yang Lv and Yuming Gu and Xiaocheng Zhou and Bailin Tian and Anqi Zhang and Zhimei Yang and Shizheng Chen and Jing Ma and Mengning Ding and Jing-Lin Zuo}, doi = {10.1002/anie.202418272}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418272}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual Zn5−NiS4 sites in a redox-active Metal–Organic framework enables efficient cascade catalysis for nitrate-to-ammonia conversion}, volume = {64}, year = {2025}, }
• (2025). A highly conjugated Nickel(II)-acetylide framework for efficient photocatalytic carbon dioxide reduction. ANGEW, 64(6), e202418269. (www)

  @article{ , abstract = {The incorporation of transition-metal single atoms as molecular functional entities into the skeleton of graphdiyne (GDY) to construct novel two-dimensional (2D) metal-acetylide frameworks, known as metalated graphynes (MGYs), is a promising strategy for developing efficient catalysts, which can combine the tunable charge transfer of GDY frameworks, the catalytic activity of metal and the precise distribution of single metallic centers. Herein, four highly conjugated MGY photocatalysts based on Ni II , Pd II , Pt II , and Hg II were synthesized for the first time using the ‘bottom-up’ strategy through the use of M−C bonds (−C≡C−M−C≡C−). Remarkably, the Ni II -based graphyne (TEPY-Ni-GY) exhibited the highest CO generation rate of 18.3 mmol g −1 h −1 and a selectivity of 98.8 %. This superior performance is attributed to the synergistic effects of pyrenyl and −C≡C−Ni(PBu 3 ) 2 −C≡C– moieties. The pyrenyl block functions as an intramolecular π-conjugation channel, facilitating kinetically favorable electron transfer, while the −C≡C−Ni(PBu 3 ) 2 −C≡C− moiety serves as the catalytic site that enhances CO 2 adsorption and activation, thereby suppressing competitive hydrogen evolution. This study provides a new perspective on MGY-based photocatalysts for developing highly active and low-cost catalysts for CO 2 reduction.}, archive = {J_ANGEW}, author = {Yingying Qin and Yang Wang and Jian Lu and Linli Xu and Wai-Yeung Wong}, doi = {10.1002/anie.202418269}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly conjugated Nickel(II)-acetylide framework for efficient photocatalytic carbon dioxide reduction}, volume = {64}, year = {2025}, }
• (2025). Ferrocene-functionalized atomically precise metal clusters exhibit synergistically enhanced performance for CO2 electroreduction. ANGEW, 64(6), e202418264. (www)

  @article{ , abstract = {The integration of organometallic compounds with metal nanoparticles can, in principle, generate hybrid nanocatalysts endowed with augmented functionality, presenting substantial promise for catalytic applications. Herein, we synthesize an atomically precise metal cluster (Ag 9 Cu 6 ) catalyst integrated with alkynylferrocene molecules ( Ag 9 Cu 6 -Fc ). This hybrid catalyst design facilitates a continuous electron transfer channel via an ethynyl bridge and establishes a distinctive local chemical environment, resulting in remarkably enhanced catalytic activity in CO 2 electroreduction. The Ag 9 Cu 6 -Fc catalyst achieves a record-high product selectivity of CO Faradaic efficiency of 100 % and an industrial-level CO partial current density of −680 mA/cm 2 , surpassing the performance of the Ag 9 Cu 6 cluster (62 % and −230 mA/cm 2 , respectively) without ferrocene functionalization in a membrane electrode assembly cell. Operando experimental and computational findings offer valuable insights into the role of ferrocene functionalization in synergistically improving the catalytic performance of metal clusters, propelling the advancement of metallic-organometallic hybrid nanoparticles for energy conversion technologies.}, archive = {J_ANGEW}, author = {Guocheng Deng and Hyewon Yun and Yuping Chen and Seungwoo Yoo and Kangjae Lee and Junghwan Jang and Xiaolin Liu and Chan Woo Lee and Qing Tang and Megalamane S. Bootharaju and Yun Jeong Hwang and Taeghwan Hyeon}, doi = {10.1002/anie.202418264}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418264}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ferrocene-functionalized atomically precise metal clusters exhibit synergistically enhanced performance for CO2 electroreduction}, volume = {64}, year = {2025}, }
• (2025). Crystallization-induced dimerization and solution-phase bond dissociation of stable dibenzoolympicenyl radicals. ANGEW, 64(6), e202418261. (www)

  @article{ , abstract = {Crystallization of organic materials can lead to different assembly structure with different reactivity, but this phenomenon is rarely observed for delocalized hydrocarbon radicals. This report introduces a crystallization-induced radical–radical coupling reaction, which employs a series of stable nonplanar organic π-radicals as reactants. Six stable radical congeners are synthesized, resulting in radical–radical coupling at the allenyl radical site during crystallization to produce close-shell dimers. This coupling reaction is absent in the solution phase, which highlights the importance of preorganization in the lattice. Remarkably, the attempts of cocrystallization of different congeners yielded homocoupling products instead of cross-coupling products. In specific cases, two distinct polymorphs are observed and their reactivity is different according to the distance of the reaction sites. Theoretical calculations indicate that the transition from a metastable preorganized monomer to a dimer is barrierless and spontaneous. The dimer could regenerate free radicals by heating or photoirradiation in the solution phase. This discovery may lead to controllable molecular switches.}, archive = {J_ANGEW}, author = {Xin Zhang and Huijie He and Chang Ge and Qin Xiang and Sota Sato and Menglan Lv and Xing Chen and Zhe Sun}, doi = {10.1002/anie.202418261}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418261}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystallization-induced dimerization and solution-phase bond dissociation of stable dibenzoolympicenyl radicals}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of axially chiral tetrasubstituted alkenes by copper-catalyzed C(sp2)–H functionalization of arenes with vinyl cations. ANGEW, 64(6), e202418254. (www)

  @article{ , abstract = {Axially chiral tetrasubstituted alkenes are of increasing value and interest in chemistry-related areas. However, their catalytic asymmetric synthesis remains elusive, owing to the high steric repulsion and relatively low conformational stability. Herein, we disclose the straightforward construction of atropisomeric tetrasubstituted alkenes by effective enantiocontrol in a reaction with vinyl cation intermediates. This copper-catalyzed enantioselective C(sp 2 )-H functionalization of sterically hindered (hetero)arenes with vinyl cations enables the efficient and atom-economical preparation of axially chiral acyclic tetrasubstituted styrenes and pyrrolyl ethylenes with high atroposelectivities. Importantly, this reaction represents the first example of the assembly of axially chiral alkenes via vinyl cations. Computational mechanistic studies reveal the reaction mechanism, origin of regioselectivity, Z / E selectivity and enantioselectivity. The synthetic utility has been demonstrated by diverse product derivatizations, chiral organocatalyst synthesis, as well as further applications in asymmetric catalysis.}, archive = {J_ANGEW}, author = {Chen-Yong Weng and Li-Gao Liu and Miao Sun and Xin Lu and Xin Hong and Long-Wu Ye and Bo Zhou}, doi = {10.1002/anie.202418254}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418254}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of axially chiral tetrasubstituted alkenes by copper-catalyzed C(sp2)–H functionalization of arenes with vinyl cations}, volume = {64}, year = {2025}, }
• (2025). Solvation effect-determined mechanisms of cation exchange reactions for efficient multicomponent nanocatalysts. ANGEW, 64(6), e202418248. (www)

  @article{ , abstract = {Cation exchange (CE) reaction is a classical synthesis method for creating complex structures. A lock of study on intrinsic mechanism limits its understanding and practical application. Using X-ray absorption spectroscopy, we observed that the evolution from Ru−Cl to Ru−O/OH occurs during the CE between K 2 RuCl 6 and CoSn(OH) 6 in aqueous solution, while CE between K 2 PtCl 6 and CoSn(OH) 6 is inhibited due to the failure of structural evolution from Pt−Cl to Pt−O/OH. Theoretical simulations imply that the interaction between Ru−O and CoSn(OH) 6 with Co vacancy (CoV Co Sn(OH) 6 ) endows the electron transfer, as a result of strengthened adsorption on CoV Co Sn(OH) 6 . Moreover, this mechanism is validated for CE between K 2 RuCl 6 and ASn(OH) 6 (A=Mg, Ca, Mn, Co, Cu, Zn), and CE between K 2 PdCl 6 /Na 3 RhCl 6 /K 2 IrCl 6 and CoSn(OH) 6 . Impressively, the Pt-free CoRuSn(OH) x produced via CE displays a mass activity and a power density of 15.0 A mg Ru −1 and 11.6 W mg Ru −1 , respectively, for anion exchange membrane fuel cell (AEMFC) exceeding the values of commercial PtRu/C (11.8 A mg Ru+Pt −1 and 9.0 W mg Ru+Pt −1 ). This work, for the first time, reveals the intrinsic mechanism of CE as structural evolution of target ion breaking through the traditional classic etch-adsorption mechanism and will promote fundamental research and practical application in various fields.}, archive = {J_ANGEW}, author = {Shangheng Liu and Xiaocan Wang and Wei-Hsiang Huang and Qiugen Zhang and Jiajia Han and Yingtian Zhang and Chih-Wen Pao and Zhiwei Hu and Yong Xu and Xiaoqing Huang}, doi = {10.1002/anie.202418248}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418248}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvation effect-determined mechanisms of cation exchange reactions for efficient multicomponent nanocatalysts}, volume = {64}, year = {2025}, }
• (2025). Strong replaces weak: Hydrogen bond-anchored electrolyte enabling ultra-stable and wide-temperature aqueous zinc-ion capacitors. ANGEW, 64(6), e202418242. (www)

  @article{ , abstract = {Despite aqueous electrolytes offer a great opportunity for large-scale energy storage owing to their safety and cost-effectiveness, their practical application suffers from the parasitic side reactions and poor temperature adaptability stemming from weak hydrogen-bond (HB) network in free water. Here, we propose the guiding thought “strong replaces weak” to design hydrogen bond-anchored electrolyte by introducing sulfolane (SL) for disrupting the regular weak HB network and contributing to superior temperature tolerance. Judiciously combined experimental characterization and theoretical calculation confirm that SL can remodel the primary solvation shell of metal ions, customize stable electrode interface chemistry and restrain the side reactions. Consequently, symmetric supercapacitor constructed by activated carbon (AC) electrodes is able to fully work within a voltage range of 2.4 V and reach high capacitance retention of 89.8 % after 60000 cycles. Additionally, Zn anodes exhibit ultra-stable Zn plating/stripping behaviors and a wide temperature range (−20–60 °C), and zinc-ion capacitor (Zn//AC) also delivers an excellent cycling stability with capacity retention of 99.7 % after 55000 cycles, implying that the designed electrolyte has practical application potential in extreme environments. This work proposes a novel critical solvation strategy that paves the route for the construction of ultra-stable and wide-temperature aqueous energy storage devices.}, archive = {J_ANGEW}, author = {Zhongyou Peng and Ling Tang and Shulong Li and Licheng Tan and Yiwang Chen}, doi = {10.1002/anie.202418242}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418242}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strong replaces weak: Hydrogen bond-anchored electrolyte enabling ultra-stable and wide-temperature aqueous zinc-ion capacitors}, volume = {64}, year = {2025}, }
• (2025). Solvent-dependent divergent cyclization of bicyclo[1.1.0]butanes. ANGEW, 64(6), e202418239. (www)

  @article{ , abstract = {Bicyclo[1.1.0]butanes (BCBs) have recently garnered significant research interest as versatile precursors for synthesizing potential [n.1.1] bioisosteres and multi-functionalized cyclobutanes in a straightforward and atom-economical manner. Here, we report a solvent-dependent divergent cyclization of BCBs that provides highly diastereospecific decorated cyclobutanes and oxygen-containing bicyclo[3.1.1]heptanes (BCHeps), which serve as bioisosteres of meta -substituted arenes. Additionally, an unprecedented 1,2-difunctionalization reaction mode for BCBs was explored, thus expanding the chemical space of arene bioisosteres and highly functionalized cyclobutanes.}, archive = {J_ANGEW}, author = {Fuhao Zhang and Subhabrata Dutta and Alessia Petti and Debanjan Rana and Constantin G. Daniliuc and Frank Glorius}, doi = {10.1002/anie.202418239}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418239}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-dependent divergent cyclization of bicyclo[1.1.0]butanes}, volume = {64}, year = {2025}, }
• (2025). Multi-N-heterocycle donor-acceptor conjugated amphoteric organic superstructures for superior zinc batteries. ANGEW, 64(6), e202418237. (www)

  @article{ , abstract = {Multiple redox-active amphoteric organics with more n-p fused electron transfer is an ongoing pursuit for superior zinc–organic batteries (ZOBs). Here we report multi-heterocycle-site donor-acceptor conjugated amphoteric organic superstructures (AOSs) by integrating three-electron-accepting n-type triazine motifs and dual-electron-donating p-type piperazine units via H-bonding and π–π stacking. AOSs expose flower-shaped N-heteromacrocyclic electron delocalization topologies to promise full accessibility of built-in n-p redox-active motifs with an ultralow activation energy, thus liberating superior capacity (465 mAh g −1 ) for Zn||AOSs battery. More importantly, the extended multiple donor-acceptor-fused conjugated AOSs feature satisfied discharge voltage and anti-dissolution in electrolytes, pushing both the energy density and cycle life of the ZOBs to a new level (412 Wh kg −1 and 70,000 cycles@10 A g −1 ). An anion–cation hybrid 18 e − charge storage mechanism is rationalized for heteromacrocyclic modules of AOSs cathode, entailing six tert-N motifs coupling with CF 3 SO 3 − ions at high potential and twelve imine sites coordinating with Zn 2+ ions at low potential. These findings constitute a major advance of amphoteric multielectron organic materials and stand for a good starting point for advanced ZOBs.}, archive = {J_ANGEW}, author = {Ziyang Song and Qi Huang and Yaokang Lv and Lihua Gan and Mingxian Liu}, doi = {10.1002/anie.202418237}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418237}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-N-heterocycle donor-acceptor conjugated amphoteric organic superstructures for superior zinc batteries}, volume = {64}, year = {2025}, }
• (2025). CO2-assisted controllable synthesis of PdNi nanoalloys for highly selective hydrogenation of biomass-derived 5-hydroxymethylfurfural. ANGEW, 64(6), e202418234. (www)

  @article{ , abstract = {The selective hydrogenation of 5-hydroxymethylfurfural (HMF) to 2,5-bishydroxymethyltetrahydrofuran (BHMTHF), a vital fuel precursor and solvent, is crucial for biomass refining. Herein, we report highly selective and stable PdNi nanoalloy catalysts for this deep hydrogenation process. A CO 2 -assisted green method was developed for the controllable synthesis of various bimetallic and monometallic catalysts. The PdNi/SBA-15 catalysts with various Pd/Ni ratios exhibited a volcano-like trend between BHMTHF yield and Pd/Ni ratio. Among all catalysts tested, Pd 2 Ni 1 /SBA-15 achieved the best performance, converting 99.0 % of HMF to BHMTHF with 96.0 % selectivity, surpassing previously reported catalysts. Additionally, the Pd 2 Ni 1 /SBA-15 catalyst maintained excellent stability even after five recycling runs. Catalyst characterizations (e. g., HAADF-STEM) and density functional theory (DFT) calculations confirmed the successful formation of the alloy structure with electron transfer between Ni and Pd, which accounts for the remarkable performance and stability of the catalyst. This work paves the way for developing highly selective and stable alloy catalysts for biomass valorization.}, archive = {J_ANGEW}, author = {Ruichao Guo and Yongjian Zeng and Lu Lin and Di Hu and Chunqiang Lu and Stuart Conroy and Suyu Zhang and Chen Zeng and Huixia Luo and Zhiwei Jiang and Xiaolei Zhang and Xin Tu and Kai Yan}, doi = {10.1002/anie.202418234}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418234}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CO2-assisted controllable synthesis of PdNi nanoalloys for highly selective hydrogenation of biomass-derived 5-hydroxymethylfurfural}, volume = {64}, year = {2025}, }
• (2025). Examining the impact of 3D multi-arm small molecules on PM6: Y6 blend reveals the key requirements for their electronic properties. ANGEW, 64(6), e202418225. (www)

  @article{ , abstract = {While the emergence of PM6 : Y6 active layer re-energized the organic photovoltaic community, excessive aggregation of Y6 molecules induced by their strong intermolecular interactions has limited the performance of PM6 : Y6-based organic solar cells (OSCs). Adding 3D multi-arm small-molecule acceptors is an effective strategy to inhibit such aggregation. However, to maximize OSC efficiency, these molecules should also contribute to the electronic processes. Here, by taking a benzotriazole-based 3D four-arm small molecule (i.e., SF-BTA1) as representative example, we combine molecular dynamics simulations and density functional theory calculations to examine the molecular-scale impact of 3D multi-arm small molecules on morphological characteristics (especially at the nanoscale) and electronic properties of PM6 : Y6 blends. By considering the intermolecular packing distances, density, and patterns among PM6, Y6, and SF-BTA1 components, exciton transfer rates from SF-BTA1 to Y6 or PM6, charge transfer rates from Y6 or PM6 to SF-BTA1, electron/hole transfer rates among adjacent Y6/PM6 pairs, and radiative and non-radiative recombination processes, we draw a comprehensive picture that describes how 3D multi-arm small molecules improve morphological and electronic properties of PM6 : Y6 blends and thus the OSC efficiency. Furthermore, successful rationalization of these aspects allows us to point out key requirements regarding the electronic properties of 3D multi-arm small molecules.}, archive = {J_ANGEW}, author = {Yuehao Huang and Ziwen Yu and Ailing Yin and Gao-Feng Han and Xing-You Lang and Jean-Luc Brédas and Tonghui Wang and Qing Jiang}, doi = {10.1002/anie.202418225}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418225}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Examining the impact of 3D multi-arm small molecules on PM6: Y6 blend reveals the key requirements for their electronic properties}, volume = {64}, year = {2025}, }
• (2025). Advanced eutectogel electrolyte for high-performance and wide-temperature flexible zinc-air batteries. ANGEW, 64(6), e202418223. (www)

  @article{ , abstract = {Despite ongoing challenges, achieving further breakthroughs in the development of gel polymer electrolytes with a wide temperature range, excellent liquid retention capability and enhanced anode compatibility in flexible zinc-air batteries (FZABs) remains a significant objective. This study presents a significant advancement in the development of choline chloride/ethylene glycol-polyvinyl alcohol (ChCl/EG-PVA) eutectogel electrolyte, tailored for high-performance operation across a wide temperature range. Systematic in-situ and ex-situ characterizations and theoretical simulations confirm the formation of robust hydrogen bonding and denser polymer cross-linked networks within the prepared eutectogel, leading to enhanced liquid retention ability (93.7 % after 96 h exposure to air) and ion transport capacity (ionic conductivity of 171.3 mS cm −1 ). Additionally, the zincophilicity nature of the choline cation in eutectogel effectively suppresses dendrites growth. The assembled FZAB utilizing this eutectogel electrolyte achieves a peak power density of 109.3 mW cm −2 and a cycle life of 90 h. Notably, the power density of FZAB is maintained as high as 38.2 mW cm −2 at −40 °C and 63.2 mW cm −2 at 50 °C, demonstrating its prominent suitability for applications in extreme temperature conditions. The design of eutectogel provides a novel way to achieve the high-performance FZAB.}, archive = {J_ANGEW}, author = {Yafen Zheng and Dongling Wu and Tao Wang and Qian Liu and Dianzeng Jia}, doi = {10.1002/anie.202418223}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Advanced eutectogel electrolyte for high-performance and wide-temperature flexible zinc-air batteries}, volume = {64}, year = {2025}, }
• (2025). Dual signature of chirality induced spin selectivity through spontaneous resolution of 2D Metal–Organic frameworks. ANGEW, 64(6), e202418222. (www)

  @article{ , abstract = {The Chiral-Induced Spin Selectivity (CISS) effect has emerged as a fascinating phenomenon within the realm of electron's spin manipulation, showcasing a unique interplay between electron's spin and molecular chirality. Subsequent to its discovery, researchers have been actively involved in exploring the new chiral molecules as effective spin filters. In the realm of observing the CISS effect, the conventional approach has mandated the utilization of two distinct enantiomers of chiral molecules. However, this present study represents a significant advancement by demonstrating the ability to control both spin states of electrons in a single system. In this work, we have demonstrated the preparation of chiral metal–organic frameworks (MOFs) via a “spontaneous resolution” process, obviating the requirement for chiral sources. This resulted in the production of chiral crystals exhibiting opposite handedness ( 1P and 1M) and these crystals were subsequently employed as a new class of spin filters based on CISS effect. Remarkably, this work signifies the first instance of achieving dual signature of spin selectivity from a single and exclusively achiral system through a spontaneous resolution process. This holds immense potential as it facilitates the production of two distinct spin-filtering materials from a unified system. Furthermore, we investigated the contact potential differences (CPD) of these chiral crystals and, for the first time, associated it with the preferential spin transport properties. Our findings revealed a correlation between the CPD and the chirality of the crystals, as well as the magnetization orientations of the ferromagnetic substrate, which can be elucidated by the CISS effect. In overall, the significant findings achieved using these robust and easily synthesized MOF crystals without the requirement for chiral medium represent a crucial advancement in enhancing the effectiveness of spin filtering materials to produce spintronic devices.}, archive = {J_ANGEW}, author = {Rabia Garg and Pravesh Singh Bisht and Subash Chandra Sahoo and Amit Kumar Mondal}, doi = {10.1002/anie.202418222}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418222}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual signature of chirality induced spin selectivity through spontaneous resolution of 2D Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Direct regeneration of industrial LiFePO4 black mass through a glycerol-enabled granule reconstruction strategy. ANGEW, 64(6), e202418198. (www)

  @article{ , abstract = {With the increasing sales of electric vehicles, lots of spent lithium-ion batteries (LIBs) assembled with LiFePO 4 (LFP) cathodes will retire in the next few years, posing a significant challenge for their effective and environmentally-friendly recycling. The main reason why spent LFP cathodes fail to re-utilize lies in the lattice defects caused by lithium loss and structural defects resulting from stress accumulation. In this work, we propose an in situ granule reconstruction strategy to directly regenerate spent LFP black mass (S−BM) using glycerol in industry settings. The hydroxyl groups abundant in glycerol serves as electron donor that help reduce Fe (III) and repair Fe−Li antisite defects ( Fe Li ). Additionally, the chelating properties of glycerol intervene with structurally disintegrated particles, inhibiting Oswald ripening effect and promoting bonding of grain boundaries to generate lamellar microcrystals with homogeneous grain size, recover their morphology and crystal structure after a facile annealing procedure. Furthermore, the regenerated LFP restores Fe−O bonds which further inhibits structural distortion and improve Li + migration kinetics. As a result, the regenerated industrial LFP black mass (R−BM) exhibits superior lithium storage performance with a discharge capacity of 123.2 mA h g −1 after 500 cycles at 5.0 C (a capacity retention rate of 93.1 %).}, archive = {J_ANGEW}, author = {Chengzhi Feng and Yang Cao and Lixian Song and Bo Zhao and Qin Yang and Yaping Zhang and Xijun Wei and Guangmin Zhou and Yingze Song}, doi = {10.1002/anie.202418198}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418198}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct regeneration of industrial LiFePO4 black mass through a glycerol-enabled granule reconstruction strategy}, volume = {64}, year = {2025}, }
• (2025). 2,2′-bipyridyl-4,4′-dicarboxylic acid modified buried interface of high-performance perovskite solar cells. ANGEW, 64(6), e202418176. (www)

  @article{ , abstract = {The regulation of interfaces remains a critical and challenging aspect in the pursuit of highly efficient and stable perovskite solar cells (PSCs). Here, 2,2′-bipyridyl-4,4′-dicarboxylic acid ( HBPDC ) is incorporated as an interfacial layer between SnO 2 and perovskite layers in PSCs. The two carboxylic acid moieties on HBPDC bind to SnO 2 through esterification, while its nitrogen atoms, possessing lone electron pairs, interact with uncoordinated lead (Pb 2+ ) atoms through Lewis acid-base interactions. This dual functionality enables simultaneous passivation of surface defects on both the SnO 2 and buried perovskite layers. In addition, the electron-deficient nature of HBPDC enhances interfacial energy band alignment and facilitates electron transfer from the perovskite to SnO 2 . Furthermore, the incorporation of HBPDC strengthens the interfacial adhesion, improving mechanical reliability. As a result, the PSCs exhibited an impressive power conversion efficiency (PCE) of 25.41 % under standard AM 1.5G conditions, along with remarkable environmental stability.}, archive = {J_ANGEW}, author = {Mingming Zhao and Wei-Min Gu and Ke-Jian Jiang and Xinning Jiao and Kun Gong and Fengzhu Li and Xueqin Zhou and Yanlin Song}, doi = {10.1002/anie.202418176}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418176}, shortjournal = {Angew. Chem. Int. Edit.}, title = {2,2′-bipyridyl-4,4′-dicarboxylic acid modified buried interface of high-performance perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). A piezocatalysis strategy to enable efficient redox in solid-state battery. ANGEW, 64(6), e202418174. (www)

  @article{ , abstract = {Piezocatalysis is considered to be a favorable catalytic technology by utilizing external mechanical stimulation to promote the specific redox reactions. The application of piezocatalysis in batteries is promising but faces formidable challenges. Herein, the operation principles of piezocatalysis were successfully demonstrated by constructing solid-state Li−Se and Li−S battery models with interfacial stress accumulation. Lead zirconate titanate with an ultra-high piezoelectric coefficient was applied as the piezoelectric catalyst. The uniformity of the dipole orientation in materials was essential for achieving piezocatalysis in batteries. The accumulated high-stress converts to piezopotential for catalyzing most reaction processes in batteries, while the rapid stress change prevents the internal charge reorganization, ensuring continuous efficient catalysis. The internal stress change alters the internal polarisation strength, driving excess screening charge to participate in the electrochemical reaction. Under piezocatalysis, solid-state Li−Se batteries exhibited a initial discharge capacity of 670.9 mAh g −1 (99.4 % of the theoretical value) at 0.1 C, and Li−S batteries showed a capacity of 1463 mAh g −1 at 0.2 C, which was still maintained up to 1084 mAh g −1 at an elevated rate of 0.5 C. This piezocatalysis strategy provides a strong theoretical basis and design specification for enhancing Li−Se and Li−S battery reaction kinetics.}, archive = {J_ANGEW}, author = {De-Chen Kong and Qing-Yao Zhu and De-Hui Guan and Xiao-Xue Wang and Yun-Ling Liu and Huan-Feng Wang and Ji-Jing Xu}, doi = {10.1002/anie.202418174}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418174}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A piezocatalysis strategy to enable efficient redox in solid-state battery}, volume = {64}, year = {2025}, }
• (2025). Hydrogenating polyethylene terephthalate into degradable polyesters. ANGEW, 64(6), e202418157. (www)

  @article{ , abstract = {The recycling and upcycling of polyethylene terephthalate (PET), the most widely used polyester plastic globally, has attracted growing attention concerning its disposal as non-degradable waste in the natural environment. Transforming end-of-life PET into (bio)degradable polyester offers a novel approach to managing its waste. In this study, we introduce a simple process capable of converting waste PET into degradable polyester, polyethylene terephthalate-polyethylene-1,4-cyclohexanedicarboxylate (PET-PECHD), by partly hydrogenating the aromatic rings ( x ) into aliphatic ones ( y ). The polyesters with variable x / y compositions ranging from 100/0 to 0/100 can be achieved, and the molecular weight (Mw) can be maintained when x / y >87/13 due to the nonobvious depolymerization. Pronounced depolymerization would occur with deeper hydrogenation, which generates a blend of PET-PECHD and polyethylene-1,4-cyclohexanedicarboxylate (PECHD) with lower Mw, and finally a single-type polymer PECHD. The PET-PECHD demonstrates comparable thermal stability and mechanical strength compared to PET, along with superior extensibility, barrier properties, and (bio)degradability in acidic, alkaline solutions, and moist soil. This research highlights the potential for cost-effective, large-scale production of degradable polyester from real-life plastic waste.}, archive = {J_ANGEW}, author = {Zhenbo Guo and Haoran Zhang and Haoyu Chen and Meiqi Zhang and Xiaoyan Tang and Meng Wang and Ding Ma}, doi = {10.1002/anie.202418157}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418157}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogenating polyethylene terephthalate into degradable polyesters}, volume = {64}, year = {2025}, }
• (2025). Single molecular dispersion of crown ether-decorated cobalt phthalocyanine on carbon nanotubes for robust CO2 reduction through host-guest interactions. ANGEW, 64(6), e202418156. (www)

  @article{ , abstract = {Immobilizing molecular catalysts on electro-conductive supports (for example, multi-walled carbon nanotubes, CNTs) represent a promising way to well-defined catalyst/support interfaces, which has shown appreciable performance for catalytic transformation. However, their full potential is far from achieved due to insufficient utilization of the intrinsic activity for each immobilized molecular catalyst, especially at loadings that should allow decent current densities. In the present work, we discover host–guest interaction between tetra-crown ether substituted cobalt phthalocyanine and metal ions, for example K + ions, not only eliminate catalyst aggregation at immobilization procedures but also reinforce catalyst/support interactions by additional electrostatic attractions under operational conditions. Through simple dip-coating procedures, a successful single molecular dispersion is achieved. Such a catalyst/electrode interface is stable and can selectively catalyze CO 2 -to-CO conversion with Faradaic efficiency over 96%. Importantly, this interface maintains an almost unchanged turnover frequency (TOF) across all loading conditions, implying a full utilization of the intrinsic activity of supported molecular catalysts. Therefore, a simultaneous achievement of high TOF and high current density (TOF of 111 s −1 at 38 mA cm −2 ) is achieved, in an aqueous H-type electrolyzer at an overpotential of 570 mV.}, archive = {J_ANGEW}, author = {Lei Zhu and Yi-Xuan Wang and Li-Juan Chen and Jian Li and Shuai Zhou and Qing-Qing Yang and Xu-Zhe Wang and Chen-Ho Tung and Li-Zhu Wu}, doi = {10.1002/anie.202418156}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418156}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single molecular dispersion of crown ether-decorated cobalt phthalocyanine on carbon nanotubes for robust CO2 reduction through host-guest interactions}, volume = {64}, year = {2025}, }
• (2025). Comediating adsorption and electron transfer via dual-active site catalyst construction for improving the treatment of extraction wastewater. ANGEW, 64(6), e202418151. (www)

  @article{ , abstract = {Solvent extraction is widely applied, while extraction wastewater treatment remains a huge challenge because of the stability of extractants. Heterogeneous Fenton-like catalysis is a promising method, but the short half-life of hydroxyl radicals (⋅OH) generated by hydrogen peroxide (H 2 O 2 ) activation results in unsatisfactory ⋅OH utilization and organics removal. Herein, an efficient strategy for treating extraction wastewater based on comediating adsorption and electron transfer by fluorine and nitrogen co-doped carbon (FNC) catalyst with dual-active site was developed. Specially, N sites adsorb organics and F sites activate H 2 O 2 , shortening the migration distance of ⋅OH. Theoretical calculation and di(2-ethylhexyl) phosphoric acid (D2EHPA) extraction wastewater degradation experiment showed that F site with electron acquisition can transfer electrons provided by electron-rich D2EHPA enriched at N sites to H 2 O 2 , facilitating the continuous generation of ⋅OH through lowering the energy barrier for H 2 O 2 activation. As a result, 96.49 % D2EHPA in simulated wastewater and 90.26 % total organic carbon in real extraction wastewater were removed. Moreover, FNC catalyst exhibited excellent reusability and ionic adaptability, and can be extended to the removal of various extractants. The proposed dual-active site catalyst provides an effective strategy for Fenton-like reaction to treat refractory extraction wastewater, promoting sustainable development of solvent extraction industry.}, archive = {J_ANGEW}, author = {Meirong Wu and Jiexiang Li and Wei Sun and Yue Yang}, doi = {10.1002/anie.202418151}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Comediating adsorption and electron transfer via dual-active site catalyst construction for improving the treatment of extraction wastewater}, volume = {64}, year = {2025}, }
• (2025). Current-regulated selective nickel-catalyzed electroreductive cross-electrophile carbonylation to β/γ-hydroxy ketones. ANGEW, 64(6), e202418147. (www)

  @article{ , abstract = {The nickel catalyzed multi-component cross-electrophile carbonylation which emerges as a powerful and efficient method for constructing diverse ketones has attracted increasing attention of organic chemists. However, the selectivity of this reaction poses a significant challenge. In this work, we have developed a current-regulated selective nickel-catalyzed electroreductive cross-electrophile carbonylation, which offers a direct convergent synthesis of β/γ-hydroxy ketones, which represent pivotal structural motifs found in numerous natural products, bioactive molecules, pharmaceutical compounds, and essential building blocks. A diverse range of multi-substituted β/γ-hydroxyketones can be accessed with high chemo- and regioselectivity from epoxides, aryl iodides, and a simple CO source (ClCO 2 Pr). This electroreductive carbonylation strategy exhibits high functional group tolerance and can be applied in late-stage derivatization of drugs and natural products. Notably, chiral epoxides can be employed as reactants with chirality retention, enabling the synthesis of asymmetric β-hydroxy ketones. Our approach demonstrates a novel electrochemical selectivity-controlled strategy in multi-component cross-electrophile coupling.}, archive = {J_ANGEW}, author = {Shentong Xie and Ming Lu and Pengcheng Wang and Renyi Shi}, doi = {10.1002/anie.202418147}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418147}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Current-regulated selective nickel-catalyzed electroreductive cross-electrophile carbonylation to β/γ-hydroxy ketones}, volume = {64}, year = {2025}, }
• (2025). Precisely prepared hierarchical micelles of polyfluorene-block-polythiophene-block-poly(phenyl isocyanide) via crystallization-driven self-assembly. ANGEW, 64(6), e202418131. (www)

  @article{ , abstract = {The precise preparation of hierarchical micelles is a fundamental challenge in modern materials science and chemistry. Herein, poly(di-n-hexylfluorene)- block -poly(3-tetraethylene glycol thiophene) (poly( 1 m - b - 2 n )) diblock copolymers and polyfluorene- block -polythiophene- block -poly(phenyl isocyanide) triblock copolymers were synthesized using a one-pot process via the sequential addition of corresponding monomers using a Ni(II) complex as a single catalyst for living/controlled polymerization. The crystallization-driven self-assembly of amphiphilic conjugated poly( 1 m - b - 2 n ) led to the formation of nanofibers with controlled lengths and narrow dispersity. The block copolymers exhibited white, yellow, and red emissions in different self-assembly states. By using uniform poly( 1 m - b - 2 n ) nanofibers as seeds, introducing the polyfluorene- block -polythiophene- block -poly(phenyl isocyanide) triblock polymer as a unimer in the seed growth process, and adjusting the structure of the poly(phenyl isocyanide) block and the polarity of self-assembly solvent, A−B−A triblock micelles, multiarm branched micelles, and raft micelles were prepared.}, archive = {J_ANGEW}, author = {Ya-Nan Pan and Chen-Chen Ye and Si-Lin Huang and Chao Wang and Man-Yi Han and Lei Xu}, doi = {10.1002/anie.202418131}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418131}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precisely prepared hierarchical micelles of polyfluorene-block-polythiophene-block-poly(phenyl isocyanide) via crystallization-driven self-assembly}, volume = {64}, year = {2025}, }
• (2025). Activating oxygen via the 3-electron pathway to hydroxyl radical by La−O4 single-atom on WO3 for water purification. ANGEW, 64(6), e202418122. (www)

  @article{ , abstract = {Shifting photocatalytic oxygen activation towards 3-electron (e − ) pathway to hydroxyl radicals, instead of the normal 1 e − to superoxide radicals, becomes increasingly important for pollution degradation since hydroxyl radicals possess a high oxidation potential (2.80 V). Here, we demonstrate a selective oxygen activation to hydroxyl radicals via 3 e − pathway using single atomically dispersed La based on WO 3 fabricated with oxygen vacancies to weaken La−O coordination strength (denoted as LaO 4 −WO v ). Unsaturated-state La overcomes the rate-limited step of 2 e − oxygen reduction reaction towards to hydrogen peroxide via tuning binding free energy of key reaction intermediate *OOH, stepped by easy generation of hydroxyl radicals via 1 e − . This strategy alters the activation of oxygen process from 1 e − to 3 e − . Hydrogen peroxide and hydroxyl radicals over LaO 4 −WO v produces 3.8 and 3.3 mmol L −1 h −1 , 35 and 8 times that of detected over WO 3 , respectively. Rapid and complete removal of tetracycline realizes over LaO 4 −WO v with 0.077 min −1 of rate constant, 38 times that of WO 3 . Degradation efficiencies keep greater than 98 % following five repeats, revealing a practical-utilization-level robust stability. This work builds an unsaturated-state transition metal site for manipulating oxygen activation towards an effective water purification as a representative application.}, archive = {J_ANGEW}, author = {Zhiruo Zhou and Shiyi Zhao and Zhihao Li and Pengfei Wang and Sihui Zhan and Meizhen Wang}, doi = {10.1002/anie.202418122}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418122}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activating oxygen via the 3-electron pathway to hydroxyl radical by La−O4 single-atom on WO3 for water purification}, volume = {64}, year = {2025}, }
• (2025). Packing engineering of zirconium metal-organic cages in mixed matrix membranes for CO2/CH4 separation. ANGEW, 64(6), e202418098. (www)

  @article{ , abstract = {Metal-organic cages (MOCs) have been considered as emerging zero-dimensional (0D) porous fillers to generate molecularly homogeneous MOC-based membrane materials. However, the discontinuous pore connectivity and low filler concentrations limit the improvement of membrane separation performance. Herein, we propose the dimension augmentation of MOCs in membranes using three-dimensional (3D) supramolecular MOC networks as filler materials in mixed matrix membranes (MMMs). We further explore the packing engineering of MOC networks to produce distinct polymorphs (α and β phases) for tailoring membrane performance. Synchrotron X-ray absorption and positron annihilation lifetime spectroscopy were employed to differentiate distinct MOC polymorphous networks within membranes. Gas permeation tests revealed that the corresponding MMMs showed superior CO 2 /CH 4 separation performance, exceeding the Robeson upper bound. Our proposed approach is expected to enrich the repertoire of reticular chemistry pertaining to molecular-based networks.}, archive = {J_ANGEW}, author = {Ziqi Yang and Shing Bo Peh and Shibo Xi and Yanqiu Lu and Qixing Liu and Dan Zhao}, doi = {10.1002/anie.202418098}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418098}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Packing engineering of zirconium metal-organic cages in mixed matrix membranes for CO2/CH4 separation}, volume = {64}, year = {2025}, }
• (2025). Declined s1 but constant t1 energy: Thermally activated delayed fluorescence with triplet blocking effect. ANGEW, 64(6), e202418097. (www)

  @article{ , abstract = {Thermally activated delayed fluorescence (TADF) molecules have been widely investigated in organic light emitting diodes (OLED), organic lasing, etc. Small singlet-triplet energy gap (Δ E ST ) and high radiative rate constants ( k F ) are highly desired to utilize triplet excitons efficiently and are beneficial to reduce efficiency roll-off of devices of OLED devices. The prevalent TADF molecules are via donor-acceptor molecular design, for which the decreasing of the Δ E ST is often at the expense of reducing the k F . Herein, we demonstrated a new Δ E ST modulation approach to construct TADF with high k F , based on triplet blocking effect , i.e., the extension of π-conjugation of a triplet constrainer ( IB ) leads to a gradually red-shifted S 1 but a constant T 1 energy and therefore reduced Δ E ST controlled from monomer ( IB ), monomer-linker ( IB-BF 2 ), to dimer of IB-BF 2 -IB . The natural transition orbital analysis indicates that S 1 state is delocalized while T 1 state is localized as confirmed by time resolved electron paramagnetic resonance spectroscopy. Therefore, the Δ E ST is reduced from 0.60 eV, 0.46 eV to 0.25 eV, while keeping faster radiation rate (around 10 8 s −1 ) than that of conventional donor-acceptor molecules (10 6 ∼10 7 s −1 ). As a result, the emission mechanisms are regulated from fluorescence for IB , phosphorescence/TADF dual emissions for IB-BF 2 to TADF for IB-BF 2 -IB . This paper proposed a new approach of Δ E ST modulation and a new type of TADF molecule with high radiation rate, which is crucial for fundamental photophysics as well as material science.}, archive = {J_ANGEW}, author = {Shihong Song and Fangqing Ge and Daniele Panariti and Anping Zhao and Shuhan Yu and Zhijia Wang and Hua Geng and Jianzhang Zhao and Antonio Barbon and Hongbing Fu}, doi = {10.1002/anie.202418097}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418097}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Declined s1 but constant t1 energy: Thermally activated delayed fluorescence with triplet blocking effect}, volume = {64}, year = {2025}, }
• (2025). Biomimetic elastic single-atom protrusions enhance ammonia electrosynthesis. ANGEW, 64(6), e202418095. (www)

  @article{ , abstract = {Electrocatalytic nitrogen (N 2 ) reduction reaction (eNRR) is a promising route for sustainable ammonia (NH 3 ) generation, but the eNRR efficiency is dramatically impeded by sluggish reaction kinetics. Herein, inspired by the dynamic extension-contraction of sea anemone tentacles in response to environmental changes, we propose a biomimetic elastic Mo single-atom protrusion on vanadium oxide support (pSA Mo/VOH) electrocatalyst featuring a symmetry-breaking Mo site and an elastic Mo−O 4 pyramid for efficient eNRR. In situ spectroscopy and theoretical calculations reveal that the protruding Mo-induced symmetry-breaking structure optimizes the d-electron filling of Mo, enhancing the back-donation to the π* antibonding orbital, effectively polarizing the N≡N bond and reducing the barrier from *N 2 to *N 2 H. Notably, the elastic Mo−O 4 pyramidal structure of pSA Mo provides a dynamic Mo−O microenvironment during continuous eNRR processes. This optimizes the electronic structure of the Mo sites based on different reaction intermediates, enhancing the adsorption of various N intermediates and maintaining low barriers throughout the six-step hydrogenation process. Consequently, the elastic pSA Mo/VOH exhibits an excellent NH 3 yield rate of 50.71±1.12 μg h −1 mg −1 and a Faradaic efficiency of 35.38±1.03 %, outperforming most electrocatalysts.}, archive = {J_ANGEW}, author = {Yuntong Sun and Yin Huang and Fanglei Yao and Meng Tian and Jin Wang and Wenjun Fan and Junwu Zhu and Jong-Min Lee}, doi = {10.1002/anie.202418095}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418095}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biomimetic elastic single-atom protrusions enhance ammonia electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Photo-amplified plasma membrane rupture by membrane-anchoring NIR-II small molecule design for improved cancer photoimmunotherapy. ANGEW, 64(6), e202418081. (www)

  @article{ , abstract = {Immunotherapy is a promising cancer treatment method for eradicating tumor cells by enhancing the immune response. However, there are several major obstacles to conventional phototherapy-mediated immune responses, including inadequate immunogenicity and immunosuppressive environment. Here, we present a novel photoimmunotherapy modality—the development of membrane-anchoring small molecule inducing plasma membrane rupture (PMR) by NIR-II photo-stimulation, thus evoking cell necrotic death and enhancing antitumor immunotherapy. Our top-performing membrane-anchoring small molecule (CBT-3) exhibits temperature-tunable PMR efficiency, allowing rapid necrotic death in cancer cells at 50 μM dose by using exogenous NIR-II light-mediated mild photothermal effect (1064 nm, 0.6 W cm −2 ). Further evidence indicated that this gentle therapeutic approach activated inflammatory signaling pathways in cells, enhanced immunogenic cell death, and reshaped the immunosuppressive tumor microenvironment, ultimately promoting systemic antitumor immune responses in vivo. This study represents the first instance of utilizing NIR-II photo-amplified PMR effect based on membrane-anchoring small molecule, providing a novel avenue for advancing cancer photoimmunotherapy.}, archive = {J_ANGEW}, author = {Pengfei Chen and Jie Rong and Kai Chen and Tian Huang and Qingming Shen and Pengfei Sun and Weiwei Tang and Quli Fan}, doi = {10.1002/anie.202418081}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418081}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-amplified plasma membrane rupture by membrane-anchoring NIR-II small molecule design for improved cancer photoimmunotherapy}, volume = {64}, year = {2025}, }
• (2025). Using a new Pt(II) source to make Pt(II) lantern-shaped cages, including low-symmetry, heteroleptic, and multicavity examples. ANGEW, 64(6), e202418079. (www)

  @article{ , abstract = {Current synthetic methods towards Pt(II) lantern-shaped cages involve the use of dry solvent, inert atmosphere, lengthy reaction times, and highly variable yields if isolated. Starting materials such as [Pt(CH 3 CN) 4 ](BF 4 ) 2 suffer from a poor shelf-life, reducing the synthetic accessibility of various Pt(II) architectures. A new Pt(II) source (with varied counterions), [Pt(3-ClPy) 4 ](X) 2 (3-ClPy=3-chloropyridine, X=BF 4 − , OTf − , NO 3 − ), is developed and characterised, showing greatly enhanced shelf-life characteristics under ambient atmospheric conditions. Using this starting material, the assembly of Pt(II) lantern-shaped cages was completed in as little as 1.5 hours with wet solvent and ambient atmosphere. The first examples of low-symmetry, heteroleptic and multicavity Pt(II) lantern-shaped cages are reported using this approach. Attempts towards an M 6 L 8 octahedron using a tritopic ligand instead generate an interesting M 2 L 4 cage with unbound pyridyl arms. Ligands and cages are characterised by NMR spectroscopy, IR spectroscopy, mass spectrometry, and X-ray crystallography in some cases.}, archive = {J_ANGEW}, author = {Zack T. Avery and Michael G. Gardiner and Dan Preston}, doi = {10.1002/anie.202418079}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418079}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Using a new Pt(II) source to make Pt(II) lantern-shaped cages, including low-symmetry, heteroleptic, and multicavity examples}, volume = {64}, year = {2025}, }
• (2025). Integrating machine learning and large language models to advance exploration of electrochemical reactions. ANGEW, 64(6), e202418074. (www)

  @article{ , abstract = {Electrochemical C−H oxidation reactions offer a sustainable route to functionalize hydrocarbons, yet identifying suitable substrates and optimizing synthesis remain challenging. Here, we report an integrated approach combining machine learning and large language models to streamline the exploration of electrochemical C−H oxidation reactions. Utilizing a batch rapid screening electrochemical platform, we evaluated a wide range of reactions, initially classifying substrates by their reactivity, while LLMs text-mined literature data to augment the training set. The resulting ML models for reactivity prediction achieved high accuracy (>90 %) and enabled virtual screening of a large set of commercially available molecules. To optimize reaction conditions for selected substrates, LLMs were prompted to generate code that iteratively improved yields. This human-AI collaboration proved effective, efficiently identifying high-yield conditions for 8 drug-like substances or intermediates. Notably, we benchmarked the accuracy and reliability of 12 different LLMs–including LLaMA series, Claude series, OpenAI o1, and GPT-4-on code generation and function calling related to ML based on natural language prompts given by chemists to showcase potentials for accelerating research across four diverse tasks. In addition, we collected an experimental benchmark dataset comprising 1071 reaction conditions and yields for electrochemical C−H oxidation reactions.}, archive = {J_ANGEW}, author = {Zhiling Zheng and Federico Florit and Brooke Jin and Haoyang Wu and Shih-Cheng Li and Kakasaheb Y. Nandiwale and Chase A. Salazar and Jason G. Mustakis and William H. Green and Klavs F. Jensen}, doi = {10.1002/anie.202418074}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418074}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating machine learning and large language models to advance exploration of electrochemical reactions}, volume = {64}, year = {2025}, }
• (2025). Polymeric iodine transport layer enabled high areal capacity dual plating zinc-iodine battery. ANGEW, 64(6), e202418069. (www)

  @article{ , abstract = {Iodine cathode in aqueous battery has drawn great attention due to its high energy density and high safety. However, iodine has extremely low conductivity of 1×10 −7 S cm −1 , which usually results in low specific capacity. In this work, a PVA-hydrogel layer was designed to enhance the areal capacity of zinc-iodine cell. The areal capacity of PVA-hydrogel layer modified CNT cathode showed twice as higher capacity than that of pure CNT film in a dual-plating cell, The significant enhancement of the capacity was attributed to the fast iodine transport in the PVA-hydrogel layer. Besides, the strong interaction between PVA chain and polyiodide anions prevented the shuttle effect. The PVA modified CNT cathode could stably operate for over 3000 hours with remarkably higher capacity and cycle life. We analyzed the uniquely fast transport behavior of polyiodides in PVA hydrogel by in situ Raman spectroscopy, in situ optical micrography, as well as DFT calculations. It was found that the strong binding force together with lower dissociation energy of iodine on PVA chain is the dominate reason for reduced shuttle effect and fast polyiodide transport. As a result, the assembled PVA-I 2 pouch cells showed excellent performance in both dual-plating cells and conventional-type cells.}, archive = {J_ANGEW}, author = {Dandan Yin and Boyang Li and Lanya Zhao and Na Gao and Yanan Zhang and Jie Feng and Xiaofeng Cui and Chunhui Xiao and Yaqiong Su and Kai Xi and Shujiang Ding and Hongyang Zhao}, doi = {10.1002/anie.202418069}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polymeric iodine transport layer enabled high areal capacity dual plating zinc-iodine battery}, volume = {64}, year = {2025}, }
• (2025). Single-molecule mechanoresistivity by intermetallic bonding. ANGEW, 64(6), e202418062. (www)

  @article{ , abstract = {The metal-electrode interface is key to unlocking emergent behaviour in all organic electrified systems, from battery technology to molecular electronics. In the latter, interfacial engineering has enabled efficient transport, higher device stability, and novel functionality. Mechanoresistivity – the change in electrical behaviour in response to a mechanical stimulus and a pathway to extremely sensitive force sensors – is amongst the most studied phenomena in molecular electronics, and the molecule-electrode interface plays a pivotal role in its emergence, reproducibility, and magnitude. In this contribution, we show that organometallic molecular wires incorporating a Pt(II) cation show mechanoresistive behaviour of exceptional magnitude, with conductance modulations of more than three orders of magnitude upon compression by as little as 1 nm. We synthesised series of cyclometalated Pt(II) molecular wires, and used scanning tunnelling microscopy – break junction techniques to characterise their electromechanical behaviour. Mechanoresistivity arises from an interaction between the Pt(II) cation and the Au electrode triggered by mechanical compression of the single-molecule device, and theoretical modelling confirms this hypothesis. Our study provides a new tool for the design of functional molecular wires by exploiting previously unreported ion-metal interactions in single-molecule devices, and develops a new framework for the development of mechanoresistive molecular junctions.}, archive = {J_ANGEW}, author = {Amit Sil and Chiara E. Spano and Yahia Chelli and Simon J. Higgins and Sara Sangtarash and Gianluca Piccinini and Mariagrazia Graziano and Richard J. Nichols and Hatef Sadeghi and Andrea Vezzoli}, doi = {10.1002/anie.202418062}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-molecule mechanoresistivity by intermetallic bonding}, volume = {64}, year = {2025}, }
• (2025). Diastereoselective anomeric C(sp3)−H cyclization towards the design of new cyclophane-braced glycopeptides. ANGEW, 64(6), e202418057. (www)

  @article{ , abstract = {Here we report a macrocyclization route towards the synthesis of glycophane peptides by a selective C−H arylation of the anomeric bond. This approach demonstrates the power of Pd-catalysis C−H activation to access unusual cyclic peptides.}, archive = {J_ANGEW}, author = {Sakna Bazzi and Ameni Hadj Mohamed and Dmytro Ryzhakov and Juba Ghouilem and Mehdi A. Beniddir and Vincent Gandon and Samir Messaoudi}, doi = {10.1002/anie.202418057}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418057}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diastereoselective anomeric C(sp3)−H cyclization towards the design of new cyclophane-braced glycopeptides}, volume = {64}, year = {2025}, }
• (2025). Mechanistic insights into post-translational α-keto-β-amino acid formation by a radical S-adenosyl methionine peptide splicease. ANGEW, 64(6), e202418054. (www)

  @article{ , abstract = {Radical S -adenosyl methionine enzymes catalyze a diverse repertoire of post-translational modifications in protein and peptide substrates. Among these, an exceptional and mechanistically obscure example is the installation of α-keto-β-amino acid residues by formal excision of a tyrosine-derived tyramine unit. The responsible spliceases are key maturases in a widespread family of natural products termed spliceotides that comprise potent protease inhibitors, with the installed β-residues being crucial for bioactivity. Here, we established the in vitro activity of the model splicease PcpXY to interrogate the mechanism of non-canonical protein splicing. Identification of shunt and coproducts, deuterium labeling studies, and density functional theory energy calculations of hypothesized intermediates support a mechanism involving hydrogen abstraction at tyrosine Cα as the initial site of peptide radical formation and release of 4-hydroxybenzaldehyde as the tyrosine-derived coproduct. The data illuminate key features of this unprecedented radical-mediated biotransformation yielding ketoamide pharmacophores that are also present in peptidomimetic therapeutics.}, archive = {J_ANGEW}, author = {Anna L. Vagstad and Edgars Lakis and Katja-Sophia Csizi and William Walls and Daniel Richter and Kang Soo Lee and Roman Stocker and Muriel Gugger and William E. Broderick and Joan B. Broderick and Markus Reiher and Jörn Piel}, doi = {10.1002/anie.202418054}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanistic insights into post-translational α-keto-β-amino acid formation by a radical S-adenosyl methionine peptide splicease}, volume = {64}, year = {2025}, }
• (2025). Alternating donor-acceptor ladder-type heteroarene for efficient photothermal conversion via boosting non-radiative decay. ANGEW, 64(6), e202418047. (www)

  @article{ , abstract = {The development of novel ladder-type conjugated molecules is crucial for advancing supramolecular chemistry and material science. In this study, we report a straightforward synthesis of new alternating donor-acceptor (D-A) ladder-type heteroarene, FCDTDPP , and demonstrate its application as photothermal agent for imaging and cancer therapy. FCDTDPP is constructed by vinylene bridge between cyclopentadithiophene (D) and diketopyrrolopyrrole (A) through intramolecular Friedel–Crafts type reaction. FCDTDPP exhibits unique combination of good molecular planarity, efficient intra-/intermolecular mixed D-A interactions, and local aromaticity. These features collectively contribute to its broad and intense absorptions with narrow band gap in red band of the spectra, coupled with multiple vibrational absorption feature, thereby enhancing non-radiative decay process and resulting in efficient photothermal conversion property. FCDTDPP and its nanoparticles (NPs) exhibit superior photothermal conversion performance and stability under 660 nm laser irradiation. Moreover, in vitro studies reveal that FCDTDPP NPs possess excellent biocompatibility, low cytotoxicity, and robust photothermal therapeutic efficacy, a finding further corroborated by preliminary in vivo experiments in tumor-bearing mice. This work charts a novel course for the molecular engineering of organic photothermal conversion systems, propelling relevant research forward.}, archive = {J_ANGEW}, author = {Nan Luo and Lingxiu Liu and Jinyang Luo and Zhaoqiong Zhou and Chun-Lin Sun and Xinqiang Hua and Liang Luo and Jianguo Wang and Hua Geng and Xiangfeng Shao and Hao-Li Zhang and Zitong Liu}, doi = {10.1002/anie.202418047}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418047}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Alternating donor-acceptor ladder-type heteroarene for efficient photothermal conversion via boosting non-radiative decay}, volume = {64}, year = {2025}, }
• (2025). Achieving a thermodynamic self-regulation dynamic adsorption mechanism for ammonia synthesis through selective orbital coupling. ANGEW, 64(6), e202418035. (www)

  @article{ , abstract = {With the continuous pursuing on the improvement of catalytic activity, a catalyst performed exceeding catalytic volcano plots is desired, while it is impeded by the adsorption-energy scaling relations of reaction intermediates. Numerous efforts have been focused on optimizing the initial and final intermediates to circumvent the scaling relations for an improved performance. For a step forward, simultaneously optimizing all intermediates is essential to explore the theoretical maximum of catalytic activity. Herein, we proposed a dynamic adsorption mechanism (DAM) to independently regulate the adsorption configurations of all intermediates of electrochemical nitrogen reduction reaction (NRR). To demonstrate the DAM, a multi-site NbNi 3 intermetallic is developed, which enables suitable adsorption energies of different intermediates via modulating orbital coupling mechanisms. As a result, NbNi 3 achieves an ultra-low limiting potential of NRR of −0.11 V vs . reversible hydrogen electrode (RHE). Strikingly, the theoretical result is confirmed by a proof-of-concept experiment, wherein the nanoporous NbNi 3 electrode exhibits a remarkable NH 3 yield rate of 25.89 μg h −1 cm −2 with the Faradaic efficiency of 33.15 % at −0.25 V vs . RHE. Overall, this work brings out a new strategy to avoid the scaling relations, and opens up a promising avenue toward high-efficiency NRR catalysts.}, archive = {J_ANGEW}, author = {Tian-Yi Dai and Hang Shi and Tong-Hui Wang and Xing-You Lang and Qing Jiang}, doi = {10.1002/anie.202418035}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418035}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving a thermodynamic self-regulation dynamic adsorption mechanism for ammonia synthesis through selective orbital coupling}, volume = {64}, year = {2025}, }
• (2025). Design of ligand-nonbridging sites in Metal–Organic frameworks for boosting lithium storage capacity. ANGEW, 64(6), e202418031. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) are lagging in the use of lithium-ion batteries (LIBs), ascribing to full coordination between metal nodes and organic ligands, to a large extent. By integrating a modulator into a ligand with missing bridging functionality, this study elucidates the role of non-bridging defect sites in MOFs in tailoring lithium storage performance. A fully bridged pristine MOF (p-MOF) utilizing the meso-tetra(4-carboxylphenyl) porphyrin ligand is compared with a modified MOF containing non-bridging defects (d-MOF) introduced by a homologous ligand, tris(4-carboxyphenyl) porphyrin. Spectroscopic and cryogenic low-dose electron microscopy techniques verify the presence of non-bridging defect sites in the d-MOF and reveal their explicit local structure. Density functional theory calculations show significantly enhanced Li + adsorption energies and reduced Li + migration barriers at the non-bridging sites in the d-MOF compared to the fully bridging sites in the p-MOF. As a result, the d-MOF exhibits exceptional lithium storage performance, achieving a high capacity of 761 mAh g −1 at 0.05 A g −1 and superior rate performance of 203 mAh g −1 at 5 A g −1 , which substantially outperform the p-MOF. This study highlights the potential of modulating MOFs with non-bridging defects to develop high-performance LIBs.}, archive = {J_ANGEW}, author = {Lanju Sun and Chongzhi Zhu and Lukun Li and Rumeng Zheng and Jian Yuan and Zhiliang Li and Jikai Sun and Guan Sheng and Hao Wu}, doi = {10.1002/anie.202418031}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of ligand-nonbridging sites in Metal–Organic frameworks for boosting lithium storage capacity}, volume = {64}, year = {2025}, }
• (2025). Evolution of interfacial hydration structure induced by ion condensation and correlation effects. ANGEW, 64(6), e202418029. (www)

  @article{ , abstract = {Interfacial hydration structures are crucial in wide-ranging applications, including battery, colloid, lubrication. Multivalent ions like Mg 2+ and La 3+ show irreplaceable roles in these applications, which are hypothesized due to their unique interfacial hydration structures. However, this hypothesis lacks experimental supports. Here, we provide the first observation for their interfacial hydration structures with molecular resolution using atomic force microscopy. We observed the evolution of layered hydration structures at La(NO 3 ) 3 solution-mica interfaces. As concentration increases from 25 mM to 2 M, the layer number varies from 2 to 1 and back to 2, and the interlayer thickness rises from 0.25±0.05 to 0.34±0.03 nm, with hydration force increasing from 0.27±0.07 to 1.04±0.24 nN. Theory and molecular simulation reveal that the cations form inner-sphere complexes. Multivalence induces concentration-dependent ion condensation and correlation effects, resulting in compositional and structural evolution within interfacial hydration structures. Additional experiments at seven different solid–liquid interfaces together with literature comparison confirm the universality of this mechanism for both multivalent and monovalent ions. New factors affecting interfacial hydration structures are revealed, including concentration and solvent dielectric constant. This insight provides guidance for designing interfacial hydration structures to optimize solid–liquid-interphase for battery life extension, modulate colloid stability and develop efficient lubricants.}, archive = {J_ANGEW}, author = {Han Li and Zhi Xu and Jiacheng Li and Alessandro Siria and Ming Ma}, doi = {10.1002/anie.202418029}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418029}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evolution of interfacial hydration structure induced by ion condensation and correlation effects}, volume = {64}, year = {2025}, }
• (2025). Precisely tuning band gaps of hexabenzocoronene-based MOFs toward enhanced photocatalysis. ANGEW, 64(6), e202418017. (www)

  @article{ , abstract = {Precise adjusting the band gaps in metal–organic frameworks (MOFs) is crucial for improving their visible-light absorption capacity during photocatalysis, presenting both a formidable challenge and a charming opportunity. This present study employed a symmetry-reduction strategy to pre-design six novel 4-connected ligands with systematic substituents (−NO 2 , -H, - t Bu, -OCH 3 , -OH and -NH 2 ) and synthesized the corresponding pillared-layer Zr-MOFs (NKM-668) retaining the hexaphenylbenzene fragment. Subsequently, the NKM-668 MOFs were transformed into large-π-conjugated hexabenzocoronene-based MOFs (pNKM-668) via the Scholl reaction. These twelve MOFs exhibited broad and tunable band gaps over 1.41 eV (ranging from 3.25 eV to 1.84 eV), and the photocatalytic CO 2 conversion rate raised by 33.2-fold. This study not only enriches the type of hexaphenylbenzene-based MOFs, but also paves the way for nanographene-containing MOFs in the further application of photocatalysis.}, archive = {J_ANGEW}, author = {Hao Zhang and Cha Li and Feifan Lang and Mei Li and Haoyu Liu and Di-Chang Zhong and Jun-Sheng Qin and Zhengyi Di and Dan-Hong Wang and Le Zeng and Jiandong Pang and Xian-He Bu}, doi = {10.1002/anie.202418017}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418017}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precisely tuning band gaps of hexabenzocoronene-based MOFs toward enhanced photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Bimagnetic Core/Shell nanoprobes with tunable exchange coupling for high resolution and sensitive magnetic particle imaging. ANGEW, 64(6), e202418015. (www)

  @article{ , abstract = {Magnetic particle imaging (MPI) has demonstrated versatile applications in biomedicine, including tumor imaging, cell tracking, and image-guided hyperthermia. Despite these advancements, the prevalent use of clinically approved tracers has posed limitations on MPI′s resolution and sensitivity. In this study, we engineered a bimagnetic core/shell nanocrystals (BMCS) tailored for MPI by optimizing the heterostructure and modulating the exchange coupling effect between the two magnetic components. The resulting BMCS exhibited remarkably heightened susceptibility and magnetization while maintaining low coercivity, thereby substantially improved both MPI resolution and sensitivity compared to conventional tracers such as VivoTrax. At an equivalent mass concentration, BMCS demonstrated a notable 5.08-fold increase in signal intensity and achieved an unprecedentedly high resolution down to 1 mm. The excellent MPI performance contributes to high resolution MPI and the sensitive detection of orthotopic colorectal cancer in mice. The design strategy employed in BMCS, centered on the exchange coupling effect, introduces an efficacious approach for the development of high performance MPI tracers.}, archive = {J_ANGEW}, author = {Qilong Li and Changjian Li and Yueqi Wang and Miaomiao Li and Zeyu Liang and Qiyue Wang and Bingzhe Wang and Canyu Huang and Jie Tian and Fangyuan Li and Daishun Ling}, doi = {10.1002/anie.202418015}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418015}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bimagnetic Core/Shell nanoprobes with tunable exchange coupling for high resolution and sensitive magnetic particle imaging}, volume = {64}, year = {2025}, }
• (2025). Unraveling the configuration modulation in spiro-based through-space charge transfer materials. ANGEW, 64(6), e202418008. (www)

  @article{ , abstract = {Thermally activated delayed fluorescence (TADF) materials hold promise for optoelectronic applications. Among various design strategies, through-space charge transfer (TSCT) systems offer the potential for enhanced performance. However, the relationship between molecular configuration and TSCT properties remains unclear compared to traditional through-band charge transfer materials. In this study, we investigated the influence of spatial configuration on TSCT features and electronic properties of triplet excited states in these TSCT materials. By manipulating the spatial arrangement between donor and acceptor segments using different spiro skeletons, a series of TSCT materials ( DMB2 - DMB5 ) was synthesized. Together with the parent molecule, DM-B , these materials exhibited completely different TADF characteristics, demonstrating the impact of spatial arrangements on their optoelectronic properties. Thus, the external quantum efficiency of these materials ranged from as high as 28.0 % ( DMB2 ) to as low as 3.6 % ( DMB5 ) due to variations in their TADF characteristics. Our findings highlight the significance of spatial configuration, beyond distance alone, in influencing TSCT properties when donor and acceptor segments are sufficiently close. This insight provides valuable guidance for developing advanced TSCT materials and advancing TADF systems with improved performance and functionality.}, archive = {J_ANGEW}, author = {Yang-Kun Qu and Qi Zheng and Dong-Ying Zhou and Lin-Song Cui and Liang-Sheng Liao and Zuo-Quan Jiang}, doi = {10.1002/anie.202418008}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202418008}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the configuration modulation in spiro-based through-space charge transfer materials}, volume = {64}, year = {2025}, }
• (2025). Self-promoted controlled ring-opening polymerization via side chain-mediated proton transfer for the synthesis of tertiary amine-pendant polypeptoids. ANGEW, 64(6), e202417990. (www)

  @article{ , abstract = {Proton transfer is essential in virtually all biochemical processes, with enzymes facilitating this transfer by optimizing the proximity and orientation of reactants through site-specific hydrogen bonds. Proton transfer is also crucial in the rate-determining step for the ring-opening polymerization of N -carboxyanhydrides (NCAs), widely used to prepare various peptidomimetic materials. This study utilizes side chain-assisted strategy to accelerate the rate of chain propagation by using NCAs with tertiary amine pendants. This moiety enables hydrogen bond formation between the incoming NCA and the polymer amino growing end. The tertiary amine side chain of the NCA forms a proton shuttle, via a less constrained transition state, to facilitate the proton transfer process. Moreover, the tertiary amine side chains enable the precipitation of NCA monomers through in situ protonation during the monomer synthesis. This greatly facilitates the synthesis of these unreported monomers, allowing the direct controlled synthesis of tertiary amine-pendant polypeptoids. This side chain-promoted polymerization has rarely been reported. Additionally, the tertiary amine side chains, as widely used functional groups, endow the polymers with unique properties including pH- and thermo-responsiveness, tunable p K a s, and siRNA transfection capability. The self-promoted synthesis, facile monomer preparation, and attractive properties make tertiary amine-pendant polypeptoids promising materials for various applications.}, archive = {J_ANGEW}, author = {Mingzhen Liao and Yao Yao and Kunyu Gan and Xianghua Su and Ning Zhao and Ronald N. Zuckermann and Sunting Xuan and Zhengbiao Zhang}, doi = {10.1002/anie.202417990}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417990}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-promoted controlled ring-opening polymerization via side chain-mediated proton transfer for the synthesis of tertiary amine-pendant polypeptoids}, volume = {64}, year = {2025}, }
• (2025). Regulating intermolecular hydrogen bonds in organic cathode materials to realize ultra-stable, flexible and low-temperature aqueous zinc-organic batteries. ANGEW, 64(6), e202417988. (www)

  @article{ , abstract = {Rational design of molecular structures is one of the effective strategies to obtain high-performance organic cathode materials. However, besides the optimization of single-molecule structures, the influence of the “weak” interaction forces (e.g. hydrogen bonds) in organic cathode materials on the performance of batteries should be fully considered. Herein, three organic small molecules with different numbers of hydroxyl groups (namely nitrogen heterocyclic tetraketone (DAB), monohydroxyl nitrogen heterocyclic dione (HDA), dihydroxyl nitrogen heterocyclic dione (DHT)) were selected as the cathodes of aqueous zinc ion batteries (AZIBs), and the effect of the intermolecular hydrogen bonds on their electrochemical performance was studied for the first time. Clearly, the stable hydrogen-bond networks built through the hydroxyl groups significantly enhance the cycle stability of organic small-molecule cathodes and facilitate rapid proton conduction between the hydrogen-bond networks through the Grotthuss mechanism, thereby endowing them with excellent rate performance. In addition, a larger and more dense two-dimensional hydrogen-bond network can be constructed through multiple hydroxyl groups, further enhancing the structural stability of organic small-molecule cathodes, giving them better cycle tolerance, excellent rate performance, and extreme environmental tolerance.}, archive = {J_ANGEW}, author = {Chaojian Ding and Yuxuan Zhao and Weifeng Yin and Fangyuan Kang and Weiwei Huang and Qichun Zhang}, doi = {10.1002/anie.202417988}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417988}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating intermolecular hydrogen bonds in organic cathode materials to realize ultra-stable, flexible and low-temperature aqueous zinc-organic batteries}, volume = {64}, year = {2025}, }
• (2025). Membrane-free water electrolysis for hydrogen generation with low cost. ANGEW, 64(6), e202417987. (www)

  @article{ , abstract = {Conventional water electrolysis relies on expensive membrane-electrode assemblies and sluggish oxygen evolution reaction (OER) at the anode, which makes the cost of green hydrogen (H 2 ) generation much higher than that of grey H 2 . Here, we develop an innovative and efficient membrane-free water electrolysis system to overcome these two obstacles simultaneously. This system utilizes the thermodynamically more favorable urea oxidation reaction (UOR) to generate clean N 2 over a new class of Cu-based catalyst (Cu X O) for replacing OER, fundamentally eliminating the explosion risk of H 2 and O 2 mixing while removing the need for membranes. Notably, this membrane-free electrolysis system exhibits the highest H 2 Faradaic efficiency among reported membrane-free electrolysis work. In situ spectroscopic studies reveal that the new N 2 H y intermediate-mediated UOR mechanism on the Cu X O catalyst ensures its unique N 2 selectivity and OER inertness. More importantly, an industrial-type membrane-free water electrolyser (MFE) based on this system successfully reduces electricity consumption to only 3.78 kWh Nm −3 , significantly lower than the 5.17 kWh Nm −3 of commercial alkaline water electrolyzers (AWE). Comprehensive techno-economic analysis (TEA) suggests that the membrane-free design and reduced electricity input of the MFE plants reduce the green H 2 production cost to US$1.81 kg −1 , which is lower than those of grey H 2 while meeting the technical target (US$2.00–2.50 kg −1 ) set by European Commission and United States Department of Energy.}, archive = {J_ANGEW}, author = {Xintong Gao and Pengtang Wang and Xiaogang Sun and Mietek Jaroniec and Yao Zheng and Shi-Zhang Qiao}, doi = {10.1002/anie.202417987}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417987}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Membrane-free water electrolysis for hydrogen generation with low cost}, volume = {64}, year = {2025}, }
• (2025). Three-dimensional covalent organic framework with dense lithiophilic sites as protective layer to enable high-performance lithium metal battery. ANGEW, 64(6), e202417973. (www)

  @article{ , abstract = {Lithium (Li) metal batteries with remarkable energy densities are restrained by short lifetime and low Coulombic efficiency (CE), resulting from the accumulative Li dendrites and dead Li during cycling. Here, we prepared a new three-dimensional (3D) covalent organic framework (COF) with dense lithiophilic sites (heteoatom weight contents of 32.32 wt %) as an anodic protective layer of Li metal batteries. The 3D COF was synthesized using a [6+4] synthesis strategy by inducing flexible 6-connected cyclotriphosphazene derivative aldehyde and 4-connected porphyrin-based tetraphenylamines. Both phosphazene and porphyrin rings in the COF served as electron-rich and lithiophilic sites, enhancing a homogeneous Li + flux via 3D direction towards highly smooth and compact Li deposition. The Li/Por-PN-COF-Cu cells achieved a record average CE of 99.1 % for 320 cycles with smooth Li deposition. Meanwhile, the abundant lithiophilic sites can promote fast Li + transport with Li + transference number of 0.87, enabling LiFePO 4 full cell with stable stripping/plating processes even at a harsh rate of 5 C. Theoretical calculations revealed that the strong interaction force between Li + and the COF facilitated the dissolution of Li + from the electrolyte, and the low migration barrier of 1.08 eV indicated a favorable interaction between the Li + ions and the π-electron system.}, archive = {J_ANGEW}, author = {Shuang Zheng and Yubin Fu and Shuai Bi and Xiubei Yang and Xiaoyu Xu and Xuewen Li and Qing Xu and Gaofeng Zeng}, doi = {10.1002/anie.202417973}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three-dimensional covalent organic framework with dense lithiophilic sites as protective layer to enable high-performance lithium metal battery}, volume = {64}, year = {2025}, }
• (2025). Fullerene-hybridized fused-ring electron acceptor with high dielectric constant and isotropic charge transport for organic solar cells. ANGEW, 64(6), e202417951. (www)

  @article{ , abstract = {A novel isotropic fullerene-hybridized fused-ring electron acceptor, designated C 60 -Y, has been synthesized via a mild [4+2] Diels–Alder cycloaddition reaction with fullerene C 60 to enhance the performance of organic solar cells (OSCs). Comparative analysis shows that C 60 -Y significantly outperforms the control acceptor Me−Y, with a notable increase in the relative dielectric constant from 2.79 to 3.95. This improvement enhances exciton dissociation and reduces non-radiative energy losses. Additionally, the isotropic molecular packing of C 60 -Y, similar to fullerene, facilitates efficient interface formation with donor polymers and improves charge mobility. As a result, incorporating C 60 -Y as an electron acceptor increases the power conversion efficiency (PCE) of binary OSCs to 15.02 %, surpassing the 13.31 % achieved with Me−Y. Moreover, when integrated into a ternary blend system, an impressive PCE of 19.22 % is achieved, top-performing among reported ternary OSCs utilizing fullerene derivatives as the third component. These results suggest that fullerene-hybridized acceptors like C 60 -Y hold great potential for advancing high-efficiency OSCs by enhancing exciton dissociation, reducing energy losses, and improving charge mobility.}, archive = {J_ANGEW}, author = {Haisheng Fang and Qiaomei Chen and Yi Lin and Xinjie Xu and Jiali Wang and Mengdi Li and Chengyi Xiao and Christopher R. McNeill and Zheng Tang and Zhou Lu and Weiwei Li}, doi = {10.1002/anie.202417951}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417951}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fullerene-hybridized fused-ring electron acceptor with high dielectric constant and isotropic charge transport for organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Unlocking the ultrafast deposition kinetics within bi-tailored core-shell structured carbon nanofibers for highly efficient and ultrastable sodium metal batteries. ANGEW, 64(6), e202417930. (www)

  @article{ , abstract = {Sodium metal anodes (SMA), featuring high energy content, low electrochemical potential and easy availability, are a compelling option for sustainable energy storage. However, notorious sodium dendrite and unstable solid-electrolyte interface (SEI) have largely retarded their widespread implantation. Herein, porous amorphous carbon nanofiber embedded with Bi nanoparticles in nanopores (Bi@NC) was rationally designed as a 3D host for SMA. In situ and ex situ characterizations, along with theoretical simulations unlock that the in-situ formed Na−Bi alloy significantly accelerates sodium metal nucleation and sodium ion diffusion kinetics, enabling uniform sodium plating within the void spaces and a stable SEI outside the carbon nanofiber. Particularly, the Bi@NC electrode achieved a high coulombic efficiency of 99.99 % at 3 mA cm −2 and 3 mAh cm −2 in half-cell tests, a cycle life of 1000 hours at 5 mA cm −2 and 10 mAh cm −2 , and sustained performance over 600 cycles under harsh conditions under 30 mA cm −2 and 3 mAh cm −2 within symmetrical cells. The full battery assembled with a Na 3 V 2 (PO 4 ) 3 @C cathode and Bi@NC anode delivered long-term cyclability over 800 cycles, demonstrating its potential for flexible application of sodium-based energy storage systems. This work highlights the Bi@NC electrode as a promising candidate for high-performance and flexible sodium metal batteries.}, archive = {J_ANGEW}, author = {Menghuan Yuan and Hui Wang and Tingting Xu and Ningning Chu and Dezhi Kong and Longhui Zeng and Ye Wang and Xuedong Bai and Ho Seok Park}, doi = {10.1002/anie.202417930}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417930}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking the ultrafast deposition kinetics within bi-tailored core-shell structured carbon nanofibers for highly efficient and ultrastable sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Unprecedented photoinduced-electron-transfer probe with a turn-ON chemiluminescence mode-of-action. ANGEW, 64(6), e202417924. (www)

  @article{ , abstract = {PeT-based fluorescent probes were demonstrated to be powerful tools for detection and imaging, owing to their significant fluorescence enhancement in response to specific targets. While numerous examples of fluorescence-based PeT have been frequently reported, there is not even a single example of a PeT probe that operates via a chemiluminescence mode. Here we report the first PeT-based turn-on probe that acts via a chemiluminescent operation mode. We designed, synthesized, and evaluated a novel chemiluminescent probe, featuring a PeT-based turn-on mechanism. The probe consists of a phenoxy-1,2-dioxetane, linked to an azide unit that acts as a PeT quencher. Upon cycloaddition of a strained cycloalkyne with the azide, a triazole-dioxetane is formed, which undergoes relatively slow chemiexcitation, resulting in a measurement window with an exceptionally high signal-to-noise ratio (over 5000-fold). The PeT-dioxetane probe could effectively detect and image two model proteins labeled with strained cycloalkyne units (Myc-DBCO and Max-DBCO) through either NHS or maleimide conjugations. Comparative analysis shows that our PeT-based chemiluminescent probe significantly outperforms a commercially available fluorescent analog. We anticipate that the insights gained from this study will facilitate the development of additional chemiluminescent probes utilizing various PeT-quenching pathways.}, archive = {J_ANGEW}, author = {Maya David and Sara Gutkin and Raj V. Nithun and Muhammad Jbara and Doron Shabat}, doi = {10.1002/anie.202417924}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unprecedented photoinduced-electron-transfer probe with a turn-ON chemiluminescence mode-of-action}, volume = {64}, year = {2025}, }
• (2025). Production of branched alkanes by upcycling of waste polyethylene over controlled acid sites of SO4/ZrO2-Al2O3 catalyst. ANGEW, 64(6), e202417923. (www)

  @article{ , abstract = {Branched alkanes, which enhance the octane number of gasoline, can be produced from waste polyethylene. However, achieving highly selective production of branched alkanes presents a significant challenge in the upcycling of waste polyethylene. Here, we report a one-pot process to convert polyethylene into gasoline-range hydrocarbons (C 4 –C 13 ) with yield of 73.3 % over SO 4 /ZrO 2 -Al 2 O 3 catalyst at 280 °C. The proportion of branched alkanes reaches 90.1 % within the C 4 –C 13 fraction. Incorporation of sulfate group endows the catalyst with strong Lewis acid sites and weak and moderate Brønsted acid sites. In situ X-ray absorption, in situ infrared spectroscopy, in situ small angle neutron scattering, and DFT calculations reveal that polyethylene activation occurs through the synergy between sulfate groups and strong Lewis acid sites (Zr sites). The weak and moderate Brønsted acid sites preferentially catalyze the isomerization and type A β-scission processes, which favors the formation of branched alkanes, while suppressing competing reactions that produce straight-chain alkanes.}, archive = {J_ANGEW}, author = {Wanying Han and Longfei Lin and Ziyu Cen and Yubin Ke and Qian Xu and Junfa Zhu and Xuelei Mei and Zhanghui Xia and Xinrui Zheng and Yaqin Wang and Yani Liu and Mingyuan He and Haihong Wu and Buxing Han}, doi = {10.1002/anie.202417923}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Production of branched alkanes by upcycling of waste polyethylene over controlled acid sites of SO4/ZrO2-Al2O3 catalyst}, volume = {64}, year = {2025}, }
• (2025). Spontaneous generation of alkoxide radical from alcohols on microdroplets surface. ANGEW, 64(6), e202417920. (www)

  @article{ , abstract = {Water microdroplets have been demonstrated to exhibit extraordinary chemical behaviors, including the abilities to accelerate chemical reactions by several orders of magnitude and to trigger reactions that cannot occur in bulk water. One of the most striking examples is the spontaneous generation of hydroxyl radical from hydroxide ions. Alcohols and alkoxide ions, being structurally similar to water and hydroxide ions, might exhibit similar behavior on microdroplets. Here, we report the spontaneous generation of alkoxide radicals from alcohols (RCH 2 OH) in aqueous microdroplets through quantum chemical calculations, quantum mechanical/molecular mechanical (QM/MM) molecular dynamics (MD) simulations, ab initio MD simulations, and mass spectrometry. Our results show that an electric field (EF) on the order of 10 −1 V/Å and partial solvation at the air-water interface jointly promote the dissociation of RCH 2 OH into RCH 2 O − and H 3 O + ions. QM/MM MD simulations indicate that RCH 2 O − can be ionized to produce RCH 2 O⋅ radicals on the microdroplet surface. Furthermore, partial solvation and the EF collaboratively catalyze the isomerization of the RCH 2 O⋅ radical into a more stable tautomer, R⋅CHOH. This study highlights the molecular mechanisms underlying the widespread generation of radicals at the microdroplet surface and provides insights into the importance of fundamental alcohol chemistry in the atmosphere.}, archive = {J_ANGEW}, author = {Ye-Guang Fang and Xiaoxu Li and Chang Yuan and Xiaojiao Li and Xu Yuan and Dongmei Zhang and Xinxing Zhang and Chongqin Zhu and Wei-Hai Fang}, doi = {10.1002/anie.202417920}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417920}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spontaneous generation of alkoxide radical from alcohols on microdroplets surface}, volume = {64}, year = {2025}, }
• (2025). Unclicking the click: A depolymerizable clicked polymer via two consecutive single-crystal-to-single-crystal reactions. ANGEW, 64(6), e202417905. (www)

  @article{ , abstract = {We report here a clicked polymer that can be depolymerized by a declicking reaction. A designed dipeptide monomer, upon heating its crystals, underwent a single-crystal-to-single-crystal topochemical ene-azide cycloaddition polymerization to form a triazoline-linked polymer, which upon further heating, underwent a remarkable SCSC denitrogenation, resulting in an imine-linked polymer quantitatively. As both the TEAC polymerization and the denitrogenation occurred in SCSC fashion, the structures of the triazoline-linked polymer and the imine-linked polymer could be determined at atomic resolution by SCXRD. Acid hydrolysis of the imine-linked polymer leads to quantitative depolymerization, yielding a dipeptide, showcasing the degradability and depolymerizability of such polymers. This solid-state click polymerization and denitrogenation yielding depolymerizable polymer is attractive over the usual click polymers that cannot be unclicked.}, archive = {J_ANGEW}, author = {Bichu Sebastian and Kana M. Sureshan}, doi = {10.1002/anie.202417905}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417905}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unclicking the click: A depolymerizable clicked polymer via two consecutive single-crystal-to-single-crystal reactions}, volume = {64}, year = {2025}, }
• (2025). Ultra-efficient heat transport across a “2.5D” all-carbon sp2/sp3 hybrid interface. ANGEW, 64(6), e202417902. (www)

  @article{ , abstract = {Single- and few-layer graphene-based thermal interface materials (TIMs) with extraordinary high-temperature resistance and ultra-high thermal conductivity are very essential to develop the next-generation integrated circuits. However, the function of the as-prepared graphene-based TIMs would undergo severe degradation when being transferred to chips, as the interface between the TIMs and chips possesses a very small interfacial thermal conductance. Here, a “2.5D” all-carbon interface containing rich covalent bonding, namely a sp 2 /sp 3 hybrid interfaces is designed and realized by a plasma-assisted chemical vapor deposition with a function of ultra-rapid quenching. The interfacial thermal conductance of the 2.5D interface is excitingly very high, up to 110–117 MWm −2 K −1 at graphene thickness of 12–25 nm, which is even more than 30 % higher than various metal/diamond contacts, and orders of magnitude higher than the existing all-carbon contacts. Atomic-level simulation confirm the key role of the efficient heat conduction via covalent C−C bonds, and reveal that the covalent-based heat transport could contribute 85 % to the total interfacial conduction at a hybridization degree of 22 at %. This study provides an efficient strategy to design and construct 2.5D all-carbon interfaces, which can be used to develop high performance all-carbon devices and circuits.}, archive = {J_ANGEW}, author = {Lin Qiu and Haimo Li and Xiaolu Yuan and Fengcheng Li and Yanhui Feng and Chengming Li and Jinlong Liu and Xiaohua Zhang}, doi = {10.1002/anie.202417902}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417902}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-efficient heat transport across a “2.5D” all-carbon sp2/sp3 hybrid interface}, volume = {64}, year = {2025}, }
• (2025). The influence of alkyl spacers and molecular weight on the charge transport and storage properties of oxy-bithiophene-based conjugated polymers. ANGEW, 64(6), e202417897. (www)

  @article{ , abstract = {Conjugated polymers (CPs) with polar side chains can conduct electronic and ionic charges simultaneously, making them promising for bioelectronics, electrocatalysis and energy storage. Recent work showed that adding alkyl spacers between CP backbones and polar side chains improved electronic charge carrier mobility, reduced swelling and enhanced stability, without compromising ion transport. However, how alkyl spacers impact polymer backbone conformation and, subsequently, electronic properties remain unclear. In this work, we design two oxy-bithiophene-based CP series, each featuring progressively extended alkyl spacer lengths and two distinct molecular weight (MW) distributions. Using operando characterisations, we evaluate the (spectro)electrochemical and swelling properties of the polymer thin films, and their performance in organic field-effect transistors and organic electrochemical transistors. Surprisingly, alkyl spacers negatively impact the hole mobility of our polymers, with higher MW amplifying this effect. Using molecular dynamics simulations, we show that it is thermodynamically favourable for adjacent non-polar alkyl spacers to aggregate in polar electrolytes, leading to backbone twisting. Further spectroscopic measurements corroborate this prediction. Our findings demonstrate the active interactions between side chain structure, MW and electrolyte/solvent polarity in influencing polymer performance, underscoring the importance of considering solvation environment effects on polymer conformation when designing new mixed conducting CPs for electrochemical applications.}, archive = {J_ANGEW}, author = {Hang Yu and Adam Marks and Sachetan M. Tuladhar and Nicholas Siemons and Iona Anderson and Sophia Bidinger and Scott T. Keene and Tyler J. Quill and Ruiheng Wu and Olivia Gough and Guanchen Wu and Flurin Eisner and Alberto Salleo and Jonathan Rivnay and George G. Malliaras and Piers R. F. Barnes and Iain McCulloch and Jenny Nelson}, doi = {10.1002/anie.202417897}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417897}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The influence of alkyl spacers and molecular weight on the charge transport and storage properties of oxy-bithiophene-based conjugated polymers}, volume = {64}, year = {2025}, }
• (2025). Hexafluorophosphate-triggered hydrogen isotope exchange (HIE) in fluorinated environments: A platform for the deuteration of aromatic compounds via strong bond activation. ANGEW, 64(6), e202417889. (www)

  @article{ , abstract = {There is a perpetual need for efficient and mild methods to integrate deuterium atoms into carbon frameworks through late-stage modifications. We have developed a simple and highly effective synthetic route for hydrogen isotope exchange (HIE) in aromatic compounds under ambient conditions. This method utilizes catalytic amounts of hexafluorophosphate (PF 6 − ) in deuterated 1,1,1,3,3,3-hexafluoroisopropanol (HFIP- d 1 ) and D 2 O. Phenols, anilines, anisoles, and heterocyclic compounds were converted with high yields and excellent deuterium incorporations, which allows for the synthesis of a wide range of deuterated aromatic compounds. Spectroscopic and theoretical studies show that an interactive H-bonding network triggered by HFIP- d 1 activates the typically inert P−F bond in PF 6 − for D 2 O addition. The thus in situ formed DPO 2 F 2 then triggers HIE, offering a new way to deuterated building blocks, drugs, and natural-product derivatives with high deuterium incorporation via the activation of strong bonds.}, archive = {J_ANGEW}, author = {Yang Ni and Jonathan Lebelt and Milena Barp and Florian Kreuter and Hannah Buttkus and Jiaye Jin and Martin Kretzschmar and Ralf Tonner-Zech and Knut R. Asmis and Tanja Gulder}, doi = {10.1002/anie.202417889}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417889}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hexafluorophosphate-triggered hydrogen isotope exchange (HIE) in fluorinated environments: A platform for the deuteration of aromatic compounds via strong bond activation}, volume = {64}, year = {2025}, }
• (2025). Configuration-mediated efficient non-radiative transition for r848-assisted photothermal immunotherapy to inhibit tumor growth and metastasis by an in situ tumor vaccine strategy. ANGEW, 64(6), e202417871. (www)

  @article{ , abstract = {Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as a safe and potent therapeutic approach, demonstrating the capability to suppress tumor growth and metastasis. While researchers have extensively investigated various structural modifications to enhance photothermal conversion performance, the influence of molecular configuration has received comparatively limited attention. In this study, we synthesized two isomers, CZTBT and LVTBT, which possessed distinct configurations. LVTBT, characterized by a flatter molecular configuration, exhibited an extended absorption wavelength and a higher molar extinction coefficient. Its excited state facilitated stronger rotation for non-radiative transitions, leading to a high photothermal conversion efficiency (PCE) of 36.3 %. When combined with R848, LVTBT@R848 nanoparticles (NPs)-mediated photothermal immunotherapy functioned as an in situ tumor vaccine, promoting the maturation of dendritic cells (DCs), T cell infiltration, and the differentiation of natural killer (NK) cells and memory T cells, thereby activating the strong immune response. Consequently, it significantly inhibited the growth of both primary and distant tumors, while also limiting lung metastasis. In summary, this study proposed a configuration-mediated non-radiative transition strategy for efficient photothermal immunotherapy, advancing the frontiers of organic photothermal agents (OPTAs) design and synthesis.}, archive = {J_ANGEW}, author = {Jianan Dai and Laiping Fang and Xuan Wang and Jie Hua and Yike Tu and Shufang Li and Kuo He and Lifeng Hang and Yuan Xu and Jin Fang and Lina Wang and Jin Wang and Ping'an Ma and Guihua Jiang}, doi = {10.1002/anie.202417871}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417871}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Configuration-mediated efficient non-radiative transition for r848-assisted photothermal immunotherapy to inhibit tumor growth and metastasis by an in situ tumor vaccine strategy}, volume = {64}, year = {2025}, }
• (2025). Topology of gemini-shaped hexagonal heterojunction for efficient stereoconvergent transformation via dynamic kinetic resolution. ANGEW, 64(6), e202417870. (www)

  @article{ , abstract = {Despite recent advances in the combination of kinetic resolution and racemization for efficient stereoconvergent transformation, the poor stability and limited reaction activities of the products restrict their wide application in industrial production. To overcome these problems, Gemini-shaped hexagons with para-heterojunctions for one-dimensional and two-dimensional supramolecular polymers were designed via hydrogen-bonding adhesion by racemization catalyst 1 and kinetic resolution 2 in this work. The polymers from the assembly of Gemini-shaped hexagons exhibit rapid catalytic behaviour with efficient selectivity for the desired configuration in the synthesis of tertiary alcohols with contiguous stereocenters through dynamic kinetic resolution for the nanoscale heterojunctions of dissimilar catalysts. Among them, the developed 2D polymers gave outstanding enantioselectivities and diastereoselectivities (>99 % ee, 20 : 1 dr) through the cooperation of adjacent dissimilar catalysts. The heterojunctions varying dimensions and distances of dissimilar catalysts provide new insight for increasing the enantioselectivity of chiral organocatalysts.}, archive = {J_ANGEW}, author = {Qi Mou and Qingqing Han and Hulin Tai and Yajun Fang and Young Yong Kim and Yingxiao Mu and Shuixia Chen and Liping Huang and Yi Zhang and Long Yi Jin and Zhegang Huang and Myongsoo Lee}, doi = {10.1002/anie.202417870}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417870}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topology of gemini-shaped hexagonal heterojunction for efficient stereoconvergent transformation via dynamic kinetic resolution}, volume = {64}, year = {2025}, }
• (2025). Cocrystallization-induced red ultralong organic phosphorescence. ANGEW, 64(6), e202417868. (www)

  @article{ , abstract = {Organic cocrystals formed through multicomponent self-assembly have attracted significant interest owing to their clear structure and tunable optical properties. However, most cocrystal systems suffer from inefficient long-wavelength emission and low phosphorescence efficiency due to strong non-radiative processes governed by the energy gap law. Herein, an efficient long-lived red afterglow is achieved using a pyrene (Py) cocrystal system incorporating a second component (NPYC4) with thermally activated delayed fluorescence (TADF) and ultralong organic phosphorescence (UOP) properties. The cocrystal (NPYC4-Py) not only inherits the excellent luminescence of its monomeric counterparts, but also exhibits unique dual-mode characteristics, including persistent TADF and UOP emission with a high quantum yield of 58 % and a lifetime of 362 ms. The precise cocrystal stacking distinctly reveals that intermolecular interactions lock the cocrystal formation and weaken the intermolecular π-π interactions between NPYC4 and Py, thereby stabilizing the excited triplet excitons. Furthermore, the favorable energy level of NPYC4 acts as a bridge, reducing the energy gap between the S 1 and T 1 states for Py, therefore activating its red phosphorescence from Py. This research provides direct insights into achieving efficient red UOP through co-crystallization.}, archive = {J_ANGEW}, author = {Zheng Yin and Zongliang Xie and Xianhe Zhang and Yufeng Xue and Deqing Zhang and Bin Liu}, doi = {10.1002/anie.202417868}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417868}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cocrystallization-induced red ultralong organic phosphorescence}, volume = {64}, year = {2025}, }
• (2025). Strength in numbers: A giant NIR-II AIEgen with one-for-all phototheranostic features for exceptional orthotopic bladder cancer treatment. ANGEW, 64(6), e202417865. (www)

  @article{ , abstract = {One-for-all phototheranostics that allows the simultaneous implementations of multiple optical imaging and therapeutic modalities by utilizing a single component, is growing into a sparkling frontier in cancer treatment. Of particular interest is phototheranostic agent with emission in the second near-infrared (NIR-II) window. Nevertheless, the practical uses of those conventional NIR-II agents are severely impeded by their unsatisfactory features including insufficient stability, low synthetic yield, to be extended absorption/ emission wavelengths, and inefficient phototheranostic outcomes. Developing exceptional phototheranostic agents is thus highly desirable yet remains formidably challenging. Herein, we synthesized two novel N -heteroacenes-based NIR-II luminogens, namely 2TT-PPT and 4TT-PBPT, by respectively employing pyrene-fused phenaziothiadiazoles and pyrene-fused bisphenaziothiadiazoles as acceptor skeletons. There is strength in numbers by increasing the fusing rings in N -heteroacenes moieties and numbers of appended donors. Compared to less ring-fused 2TT-PPT, the giant molecule 4TT-PBPT shows improved photophysical characteristics, such as enhanced light absorbance, red-shifted wavelengths, higher brightness, favorable reactive oxygen species (ROS) generation, and elevated photothermal conversion efficiency, which render 4TT-PBPT nanoparticles excellent fluorescence-photoacoustic-photothermal trimodal imaging guided photodynamic-photothermal synergistic therapy for orthotopic bladder cancer.}, archive = {J_ANGEW}, author = {Caifa You and Yiqi Zhu and Jun Zhu and Zixuan Xu and Qian Liu and Lei Wang and Weijie Zhang and Jianquan Hou and Dong Wang and Ben Zhong Tang}, doi = {10.1002/anie.202417865}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417865}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strength in numbers: A giant NIR-II AIEgen with one-for-all phototheranostic features for exceptional orthotopic bladder cancer treatment}, volume = {64}, year = {2025}, }
• (2025). Integrated Ziegler–Natta/Brookhart-ni catalysts for the synthesis of sutured polar high-impact polypropylenes. ANGEW, 64(6), e202417849. (www)

  @article{ , abstract = {The direct synthesis of polar high-impact polypropylenes using industrially-preferred heterogeneous catalysts is challenging due to the poisoning of polar functional groups towards metal center and the high stereo-selectivity requirement. In this work, dual-site catalysts combining Ziegler–Natta and Brookhart-Ni catalysts were used to produce polar polyolefin ionomers, followed by polar high-impact polypropylenes containing isotactic polypropylene and branched polyethylene as toughening agents. Three combination modes between these catalysts were investigated, including mixed, core–shell, and integrated types. The integrated dual-site catalyst achieved the optimal material properties because the polyolefin ionomer acted as a suture molecule that stitched different components into a whole network. This produced sutured polar high-impact polypropylenes with excellent mechanical properties and compatibility with polar substances. The restraining effect of the suture molecules greatly reduced the release of microplastic particles after aging. Moreover, the obtained polar high-impact polypropylene can serve as an efficient compatibilizer to recycle polyethylene/polypropylene mixed-waste plastics. This work provides an appealing and potentially practical strategy to upgrade the widely used polypropylenes and to alleviate the ever-growing plastic pollution issue.}, archive = {J_ANGEW}, author = {Yu Wang and Chao Li and Chen Tan and Changle Chen}, doi = {10.1002/anie.202417849}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417849}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated Ziegler–Natta/Brookhart-ni catalysts for the synthesis of sutured polar high-impact polypropylenes}, volume = {64}, year = {2025}, }
• (2025). Ion hydration enables generality in asymmetric catalysis: Desymmetrization to P-stereogenic triarylphosphine derivatives. ANGEW, 64(6), e202417827. (www)

  @article{ , abstract = {Asymmetric synthesis relies on seamless transmission of stereochemical information from a chiral reagent/catalyst to a prochiral substrate. The disruption by substrates’ structural changes presents a hurdle in innovating generality-oriented asymmetric catalysis. Here, we report a strategy for substrate adaptability by exploiting a fundamental physicochemical phenomenon—ion hydration, in developing remote desymmetrization to access P -stereogenic triarylphosphine oxides and sulfides. Compared to existing methods, this approach does not require pre-installed ortho substituents and avoids the use of Grignard/organolithium reagents. Simply tuning the water/ion ratio in the reaction media tailors the water-mediated ionic substrate–catalyst preorganization to counterbalance the structural changes in the substrates, thus further increasing the diversity of enantioenriched P -stereogenic compounds. This study shows that it is viable and practical to precisely manipulate ionic interactions through tuning the dynamic ion hydration in situ, thereby adding a distinctive dimension to catalyst engineering in the pursuit of substrate generality in asymmetric catalysis.}, archive = {J_ANGEW}, author = {Chi Liu and Yang Yang and Wenyang Hong and Jun-An Ma and Ye Zhu}, doi = {10.1002/anie.202417827}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417827}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ion hydration enables generality in asymmetric catalysis: Desymmetrization to P-stereogenic triarylphosphine derivatives}, volume = {64}, year = {2025}, }
• (2025). CO oxidation catalyzed by perovskites: The role of crystallographic distortions highlighted by systematic experiments and artificial intelligence. ANGEW, 64(6), e202417812. (www)

  @article{ , abstract = {The identification of key materials’ parameters correlated with the performance can accelerate the development of heterogeneous catalysts and unveil the relevant underlying physical processes. However, the analysis of correlations is often hindered by inconsistent data. Besides, nontrivial, yet unknown relationships may be important, and the intricacy of the various processes may be significant. Here, we tackle these challenges for the CO oxidation catalyzed by perovskites using a combination of rigorous experiments and artificial intelligence. A series of 13 AB O 3 ( A =La, Pr, Nd, Sm; B =Cr, Mn, Fe, Co) perovskites was synthesized, characterized, and tested in catalysis. To the resulting dataset, we applied the symbolic-regression SISSO approach. We identified an analytical expression correlated with the activity that contains the normalized unit-cell volume, the Pauling electronegativity of the elements A and B , and the ionization energy of the element B . Therefore, the activity is described by crystallographic distortions and by the chemical nature of A and B elements. The generalizability of the identified descriptor is confirmed by the good quality of the predictions for 3 additional AB O 3 and 16 chemically more complex A Mn (1- x ) B’ x O 3 ( A =La, Pr, Nd; B’ =Fe, Co, Ni, Cu, Zn) perovskites.}, archive = {J_ANGEW}, author = {Giulia Bellini and Gregor Koch and Frank Girgsdies and Jinhu Dong and Spencer J. Carey and Olaf Timpe and Gudrun Auffermann and Matthias Scheffler and Robert Schlögl and Lucas Foppa and Annette Trunschke}, doi = {10.1002/anie.202417812}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417812}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CO oxidation catalyzed by perovskites: The role of crystallographic distortions highlighted by systematic experiments and artificial intelligence}, volume = {64}, year = {2025}, }
• (2025). Diketopyrrolopyrrole-activated dynamic condensation approach to narrow-band gap vinylene-linked covalent organic frameworks. ANGEW, 64(6), e202417805. (www)

  @article{ , abstract = {Vinyl units intrinsically featuring less steric, nonpolarity, and unsaturated character, are well-known π-bridge used in the synthesis of high-performance semiconducting materials. Two-dimensional (2D) vinylene-linked covalent organic frameworks (COFs) represent a promising class of π-conjugated structures, however, the range of available monomers for the reversible formation of carbon-carbon double bonds remains limited. In this study, a new class of 2D vinylene-linked COFs were synthesized using dimethyldiketopyrrolopyrrole (DM-DPP) as the key monomer. The strong electron deficiency of diketopyrrolopyrrole (DPP) makes its methyl substituents readily activated upon the cocatalysis of L-proline and 4-dimethylaminopyridine in aqueous solution to conduct dynamic condensation with tritopic aromatic aldehydes. The resulting COFs crystallized in an eclipsed AA stacking arrangement and featured abundant, regular nanochannels. Their robust vinyl DPP-linking mode enhanced donor-π-acceptor conjugation and promoted π-stacked alignment along the vertical direction. Consequently, the synthesized COFs exhibited band gaps as narrow as 1.02 eV and demonstrated excellent light-harvesting capability across the visible to near-infrared I (NIR-I) regions. Furthermore, the COFs could be converted into free-standing thin pellets through simple pressure casting, and show excellent photothermal response and cycling stability under different light sources.}, archive = {J_ANGEW}, author = {Zixing Zhang and Fancheng Meng and Xu Chi and Yang Jiao and Bai Xue and Xiaomeng Li and Fan Zhang}, doi = {10.1002/anie.202417805}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417805}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diketopyrrolopyrrole-activated dynamic condensation approach to narrow-band gap vinylene-linked covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Integrative molecular dynamics simulations untangle cross-linking data to unveil mitochondrial protein distributions. ANGEW, 64(6), e202417804. (www)

  @article{ , abstract = {Cross-linking mass spectrometry (XL-MS) enables the mapping of protein-protein interactions on the cellular level. When applied to all compartments of mitochondria, the sheer number of cross-links and connections can be overwhelming, rendering simple cluster analyses convoluted and uninformative. To address this limitation, we integrate the XL-MS data, 3D electron microscopy data, and localization annotations with a supra coarse-grained molecular dynamics simulation to sort all data, making clusters more accessible and interpretable. In the context of mitochondria, this method, through a total of 6.9 milliseconds of simulations, successfully identifies known, suggests unknown protein clusters, and reveals the distribution of inner mitochondrial membrane proteins allowing a more precise localization within compartments. Our integrative approach suggests, that two so-far ambigiously placed proteins FAM162A and TMEM126A are localized in the cristae, which is validated through super resolution microscopy. Together, this demonstrates the strong potential of the presented approach.}, archive = {J_ANGEW}, author = {Fabian Schuhmann and Kerem Can Akkaya and Dmytro Puchkov and Svea Hohensee and Martin Lehmann and Fan Liu and Weria Pezeshkian}, doi = {10.1002/anie.202417804}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417804}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrative molecular dynamics simulations untangle cross-linking data to unveil mitochondrial protein distributions}, volume = {64}, year = {2025}, }
• (2025). Mutual dependence between membrane phase separation and bacterial division protein dynamics in synthetic cell models. ANGEW, 64(6), e202417800. (www)

  @article{ , abstract = {Cell membranes in bacteria are laterally polarized to produce specific environments for membrane proteins, e.g., proteins involved in cell division which accumulate at mid-cell or the cell poles. An interesting result of such membrane-lipid interplay is the reorganization of lipid domains together with membrane-bound proteins at the onset of cell division, suggesting functional significance of membrane compartments in the cell cycle. Here, by adopting the key bacterial division proteins MinC, MinD, MinE, FtsA and FtsZ as an archetypal spatial patterning system, we present a simple vesicle-based in vitro model to explore the mutual dependence of protein pattern formation and membrane heterogeneity. Like many other peripheral membrane proteins, Min proteins exhibit preferential binding and macro-scale pattern formation at L d domains, which leads to altered oscillation mode selection in phase-separated membrane compartments (GUVs). Moreover, incorporating bacterial division proteins within phase-separated GUVs leads to blebbing-like membrane deformations followed by the reorganization of L o domains aligning at the neck region of the bleb, which agrees well with the domain rearrangement in bacterial membranes immediately preceding the radial constriction process. Overall, the presented in vitro model system showcases a basic framework to better comprehend the cellular division mechanism in consideration of complex cellular lipid environments.}, archive = {J_ANGEW}, author = {Nishu Kanwa and Shunshi Kohyama and Leonard Fröhlich and Amogh Desai and Petra Schwille}, doi = {10.1002/anie.202417800}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417800}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mutual dependence between membrane phase separation and bacterial division protein dynamics in synthetic cell models}, volume = {64}, year = {2025}, }
• (2025). A molecular engineering approach to conformationally regulated conductance dualism in a molecular junction. ANGEW, 64(6), e202417796. (www)

  @article{ , abstract = {One key aspect for the development of functional molecular electronic devices is the ability to precisely tune and reversibly switch the conductance of individual molecules in electrode-molecule-electrode junctions in response to external stimuli. In this work, we present a new approach to access molecular switches by deliberately controlling the flexibility in the molecular backbone. We here describe two new conductance switches based on bis(triarylamines) that rely on the reversible toggling between two conformers, each associated with vastly different conductances. By molecular design, we were able to realize an on / off ratio G high / G low of ~10 3 , which is one of the largest values reported to date. Flicker noise analysis and molecular transport calculations indicate that on / off switching relies on a change of the conduction pathway and vast differences in molecule-electrode coupling. We thereby provide a new scaffold for further development of molecular conductance switches that are both efficient and easily refined.}, archive = {J_ANGEW}, author = {Moritz Nau and William Bro-Jørgensen and Michael Linseis and Michael Bodensteiner and Rainer F. Winter and Gemma C. Solomon}, doi = {10.1002/anie.202417796}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417796}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A molecular engineering approach to conformationally regulated conductance dualism in a molecular junction}, volume = {64}, year = {2025}, }
• (2025). Regioselective and homochiral supramolecular polymerization of nanotadpole aggremers of poly(phenylacetylene) derivatives. ANGEW, 64(6), e202417792. (www)

  @article{ , abstract = {Biological homochirality is a signature of life. Supramolecular polymerization is effective to achieve high hierarchical homochirality in nature, but has not been well-explored. Herein, we report regioselective and homochiral supramolecular polymerization of chiral nanotadpole aggregates made of either synthetic helical poly(phenylacetylene)s or chirality-amplified co-assembly of chiral and achiral poly(phenylacetylene)s. The twisted nanotadpole aggregates with high screw-sense preference polymerized as monomers (aggremers) into supramolecular chains in a head-to-tail regioselective and stepwise manner. Supramolecular copolymerization of enantiomeric aggremers favored formation of homochiral hierarchical supramolecular structures as visualized by TEM. Chiral hexagonal columnar mesophase of aggremers was responsive for the stereoselectivity. The work opens a gate to controllably and effectively construct functional chiral supramolecular materials and deepens the understanding of hierarchical biological homochirality.}, archive = {J_ANGEW}, author = {Hua Zeng and Peiyao Yu and Jie Zhang and Xinhua Wan}, doi = {10.1002/anie.202417792}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417792}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regioselective and homochiral supramolecular polymerization of nanotadpole aggremers of poly(phenylacetylene) derivatives}, volume = {64}, year = {2025}, }
• (2025). Hederagenin is a highly selective antagonist of the neuropeptide FF receptor 1 that reveals mechanisms for subtype selectivity. ANGEW, 64(6), e202417786. (www)

  @article{ , abstract = {RF-amide peptide receptors including the neuropeptide FF receptor 1 (NPFFR1) are G protein-coupled receptors (GPCRs) that modulate diverse physiological functions. High conservation of endogenous ligands and receptors makes the identification of selective ligands challenging. Previously identified antagonists mimic the C-terminus of peptide ligands and lack selectivity towards the closely related neuropeptide FF receptor 2 (NPFFR2) or the neuropeptide Y 1 receptor (Y 1 R). In a high-throughput screening, we identified the pentacyclic triterpenoid hederagenin ( 1 ) as a novel selective antagonist for the NPFFR1. Hederagenin ( 1 ) is a natural product isolated from Hedera helix (ivy). We characterized its mode of activity using in vitro and in silico methods, revealing an overlapping binding site of the small molecule with the orthosteric peptide agonists. Despite the high similarity of the orthosteric binding pockets of NPFFR1 and NPFFR2, hederagenin ( 1 ) shows strong subtype selectivity, particularly caused by slight differences in the shape of the binding pockets and the rigidity of the small molecule. Several residues inhibiting the activity of hederagenin ( 1 ) at the NPFFR2 were identified. As NPFFR1 antagonists are discussed as potential candidates for the treatment of chronic pain, these insights into the structural determinants governing subtype specificity will facilitate the development of next-generation analgesics with improved safety and efficacy.}, archive = {J_ANGEW}, author = {Hannah Lentschat and Fabian Liessmann and Claiborne Tydings and Tina Schermeng and Jan Stichel and Nicole Urban and Michael Schaefer and Jens Meiler and Annette G. Beck-Sickinger}, doi = {10.1002/anie.202417786}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hederagenin is a highly selective antagonist of the neuropeptide FF receptor 1 that reveals mechanisms for subtype selectivity}, volume = {64}, year = {2025}, }
• (2025). Multiple redox-active centers in an azatriangulenetrione-based covalent organic framework for high-capacity, high-rate and ultra-stable sodium-ion batteries. ANGEW, 64(6), e202417779. (www)

  @article{ , abstract = {Sodium-ion batteries (SIBs) suffer from sluggish kinetics, large volume change, and limited specific capacity due to the large radius of Na + . These issues can be solved through using covalent organic frameworks (COFs) as electrodes. Herein, an azatriangulenetrione-containing COF (denoted as CityU-33) was designed and synthesized as an electrode material for SIBs. Due to its inherent abundance of multiple redox-active sites and fast intercalation kinetics, CityU-33 delivered a high discharge capacity of 410.4 mAh g −1 at 0.1 A g −1 and showed remarkable long-term cycling stability, where a discharge capacity of 288 mAh g −1 at 0.2 A g −1 with 97 % retention over 2000 cycles was achieved, making it the top COF electrode material for SIBs.}, archive = {J_ANGEW}, author = {Fangyuan Kang and Lei Yan and Zihao Chen and Yuchan Zhang and Qianfeng Gu and Jinglun Yang and Shen Xu and Xiang Wang and Chun-Sing Lee and Yonggang Wang and Qichun Zhang}, doi = {10.1002/anie.202417779}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417779}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple redox-active centers in an azatriangulenetrione-based covalent organic framework for high-capacity, high-rate and ultra-stable sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Multifunctional nanocomposite polymer-integrated ca-doped CeO2 electrolyte for robust and high-rate all-solid-state sodium-ion batteries. ANGEW, 64(6), e202417778. (www)

  @article{ , abstract = {Due to the seamless interfaces between solid polymer electrolytes (SPEs) and electrode materials, SPEs-based all-solid-state sodium-ion batteries (ASSSIBs) are considered promising energy storage systems. However, the sluggish Na + transport and uncontrollable Na dendrite propagation still hinder the practical application of SPEs-based ASSSIBs. Herein, Ca-doped CeO 2 (Ca−CeO 2 ) nanotube framework is synthesized and integrated with poly (ethylene oxide) methyl ether acrylate-perfluoropolyether copolymer (PEOA-PFPE), resulting in multifunctional solid nanocomposite electrolytes (namely SNEs, i.e., PEOA-PFPE/Ca−CeO 2 ). Our investigations demonstrate that the fluorous effect incurred by the fluorine-containing PEOA-PFPE and the oxygen vacancy effect induced by the Ca−CeO 2 framework could synergistically promote the dissociation of sodium salt, ultimately enhancing the Na + mobility in SNEs. Besides, the resultant SNEs construct rapid Na + transport channels and homogenize the Na deposition in SNEs/Na interface, which effectively prevents the Na dendrite growth. Furthermore, the assembled carbon-coated sodium vanadium phosphate (NVP@C)||PEOA-PFPE/Ca−CeO 2 ||Na coin cell delivers impressive rate capability of 97.9 mAh g −1 at 2 C and outstanding cycling stability with capacity retention of 84.3 % after 300 cycles at 1 C. This work illustrates that constructing multifunctional SNEs via incorporating functional inorganic frameworks into fluorine-containing SPEs could be a promising strategy for the commercialization of robust and high-performance ASSSIBs.}, archive = {J_ANGEW}, author = {Pan Yang and Zhenzhen Wu and Mingli Li and Cheng Zhang and Yiqing Wang and Yutong Zhu and Meng Li and Yun Wang and Dong-sheng Li and Hao Chen and Shanqing Zhang}, doi = {10.1002/anie.202417778}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417778}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multifunctional nanocomposite polymer-integrated ca-doped CeO2 electrolyte for robust and high-rate all-solid-state sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Exploration of chemical space through automated reasoning. ANGEW, 64(6), e202417657. (www)

  @article{ , abstract = {The vast size of composition space poses a significant challenge for materials chemistry: exhaustive enumeration of potentially interesting compositions is typically infeasible, hindering assessment of important criteria ranging from novelty and stability to cost and performance. We report a tool, Comgen, for the efficient exploration of composition space, which makes use of logical methods from computer science used for proving theorems. We demonstrate how these techniques, which have not previously been applied to materials discovery, can enable reasoning about scientific domain knowledge provided by human experts. Comgen accepts a variety of user-specified criteria, converts these into an abstract form, and utilises a powerful automated reasoning algorithm to identify compositions that satisfy these user requirements, or prove that the requirements cannot be simultaneously satisfied. In contrast to machine learning techniques, explicitly reasoning about domain knowledge, rather than making inferences from data, ensures that Comgen's outputs are fully interpretable and provably correct. Users interact with Comgen through a high-level Python interface. We illustrate use of the tool with several case studies focused on the search for new ionic conductors. Further, we demonstrate the integration of Comgen into an end-to-end automated workflow to propose and evaluate candidate compositions quantitatively, prior to experimental investigation. This highlights the potential of automated formal reasoning in materials chemistry.}, archive = {J_ANGEW}, author = {Judith Clymo and Christopher M. Collins and Katie Atkinson and Matthew S. Dyer and Michael W. Gaultois and Vladimir V. Gusev and Matthew J. Rosseinsky and Sven Schewe}, doi = {10.1002/anie.202417657}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417657}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploration of chemical space through automated reasoning}, volume = {64}, year = {2025}, }
• (2025). Benzyl ammonium carbamates undergo two-step linker cleavage and improve the properties of antibody conjugates. ANGEW, 64(6), e202417651. (www)

  @article{ , abstract = {Targeted payload delivery strategies, such as antibody-drug conjugates (ADCs), have emerged as important therapeutics. Although considerable efforts have been made in the areas of antibody engineering and labeling methodology, improving the overall physicochemical properties of the linker/payload combination remains an important challenge. Here we report an approach to create an intrinsically hydrophilic linker domain. We find that benzyl α-ammonium carbamates (BACs) undergo tandem 1,6–1,2-elimination to release secondary amines. Using a fluorogenic hemicyanine as a model payload component, we show that a zwitterionic BAC linker improves labeling efficiency and reduces antibody aggregation when compared to a commonly used para -amino benzyl (PAB) linker as well as a cationic BAC. Cellular and in vivo fluorescence imaging studies demonstrate that the model payload is specifically released in antigen-expressing cells and tumors. The therapeutic potential of the BAC linker strategy was assessed using an MMAE payload, a potent microtubule-disrupting agent frequently used for ADC applications. The BAC-MMAE combination enhances labeling efficiency and cellular toxicity when compared to the routinely used PAB-Val-Cit ADC analogue. Broadly, this strategy provides a general approach to mask payload hydrophobicity and improve the properties of targeted agents.}, archive = {J_ANGEW}, author = {Xiaoyi Li and Nimit L. Patel and Joseph Kalen and Martin J. Schnermann}, doi = {10.1002/anie.202417651}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Benzyl ammonium carbamates undergo two-step linker cleavage and improve the properties of antibody conjugates}, volume = {64}, year = {2025}, }
• (2025). Abnormal freezing effect on electron conduction of ball-milled lanthanum trihydride for superionic conductor. ANGEW, 64(6), e202417610. (www)

  @article{ , abstract = {A recent finding shows that lattice deformation could transform the mixed electronic/hydride (H − ) conducting lanthanum trihydride (LaH 3 ) to a superionic H − conductor. Such a feature would enable the development of a brand-new all-solid-state hydride ion battery. It is essential to elucidate the mechanism of such a phenomenon. Here, we disclose an abnormal freezing effect on the electronic conductivity ( σ e ) of the ball-milled LaH 3 ; that is, σ e can be lowered by over 2 orders of magnitude upon a low-temperature treatment. Low-temperature Raman reveals that at low temperatures, lattice deformation has a noticeable influence on the interaction of hydrogen at octahedral (H o ) and tetrahedral (H t ) sites, which may play a crucial role in hindering electron conduction. This freezing effect can significantly improve the ionic transfer number of rare earth-based H − conductors and provide a new direction to the development of solid electrolytes for low-temperature all-solid-state batteries.}, archive = {J_ANGEW}, author = {Weijin Zhang and Shangshang Wang and Shukun Liu and Jirong Cui and Hetong Chen and Ren Zou and Yuanhua Xia and Hujun Cao and Ping Chen}, doi = {10.1002/anie.202417610}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417610}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Abnormal freezing effect on electron conduction of ball-milled lanthanum trihydride for superionic conductor}, volume = {64}, year = {2025}, }
• (2025). Glycopolymer-mediated selective separation of middle rare earth elements. ANGEW, 64(6), e202417505. (www)

  @article{ , abstract = {The selective separation of rare earth elements (REEs) remains a formidable challenge due to limitations of current methodologies, which struggle to achieve the separation efficiency required for their critical industrial applications. Middle REEs (MREEs), characterized by their intermediate ionic radii, are particularly challenging to separate without size-specific trapping mechanisms. In this study, we report a novel approach that synergistically combines heavy metal sequestration with size-selective separation, utilizing negatively charged glycopolymers to achieve the targeted separation of MREEs. We systematically investigated the binding affinities of these glycopolymers for various REEs, focusing on the selective isolation of MREEs through a controlled variation of glycopolymer properties, including degree of polymerization (DP) and charge density. Our findings reveal a distinctive U-shaped selectivity profile, with a marked preference for Samarium (Sm) and Europium (Eu) over other REEs such as Cerium (Ce), Gadolinium (Gd), and Holmium (Ho). This selectivity underscores the potential for designing tailored separation processes optimized for specific MREEs. Moreover, enrichment experiments demonstrated the practical viability of our methodology, achieving over 10 % selectivity for Sm in a Ce/Sm mixture with a 10 : 1 Ce/Sm ratio, a trend that held for Sm in a Ho/Sm Mixture with a 10 : 1 Ho/Sm ratio, indicating significant selectivity over both light and heavy REEs. A subsequent separation experiment using a 1 : 1 Ce/Sm mixture yielded a 15 % enrichment after only five passes through a filter containing minimal amounts of glycopolymer, highlighting the promise of further refinement for enhanced separation efficiency.}, archive = {J_ANGEW}, author = {Sungjin Jeon and Tyler L. Odom and Cole A. Williams and Cassandra E. Callmann}, doi = {10.1002/anie.202417505}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417505}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Glycopolymer-mediated selective separation of middle rare earth elements}, volume = {64}, year = {2025}, }
• (2025). Dynamically switchable global chirality in racemic polymer systems. ANGEW, 64(6), e202417495. (www)

  @article{ , abstract = {Any polymers composed of racemic segments are obviously optically inactive and lack any chiroptical applications. Here, we present an intriguing method for precisely generating global chirality in racemic copolymer assemblies without any external asymmetrical intervention via step-wise polymerization-induced chiral self-assembly (PICSA). Global supramolecular chirality of the nanoaggregates could be dynamically switched by the two diametrically opposed chiral conflict effects: “first come, first serve” effect and “late-comer lives above” effect, which can be controlled by the precisely specified the number and sequence of enantiomeric segments. Significantly, the supramolecular stacking manners of the racemic mesogenic building units as well as the liquid crystallinity of the solvophobic core play a crucial role for the chiral communication pathway of enantiomeric mesogens. Furthermore, such switchable global chirality in racemic polymers is broadly applicable and well regulable. We propose that this research may challenge the notion that racemic systems lack optical activity while highlighting their potential applications in functional racemic polymer materials and providing insights into the evolution of racemates towards homochirality on early Earth.}, archive = {J_ANGEW}, author = {Zixiang He and Jiaying Guo and Yuqing Wang and Haotian Ma and Xiaoxiao Cheng and Wei Zhang}, doi = {10.1002/anie.202417495}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417495}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamically switchable global chirality in racemic polymer systems}, volume = {64}, year = {2025}, }
• (2025). Spontaneously blinkogenic probe for wash-free single-molecule localization-based super-resolution imaging in living cells. ANGEW, 64(6), e202417469. (www)

  @article{ , abstract = {Single-molecule localization super-resolution fluorescence imaging relies on the fluorescence ON/OFF switching of fluorescent probes to break the diffraction limit. However, the unreacted or nonspecifically bound probes cause non-targeted ON/OFF switching, resulting in substantial fluorescence background that significantly reduces localization precision and accuracy. Here, we report a blinkogenic probe HM-DS655-Halo that remains blinking OFF until it binds to HaloTag, thereby triggering its self-blinking activity and enabling its application in direct SMLM imaging in living cells without wash-out steps. We employed the ratio of the duty cycle before and after self-blinking activation, termed as the parameter “R DC ” to characterize blinkogenicity. The covalent binding to HaloTag induces HM-DS655-Halo to transition from a fluorescent OFF state to a fluorescence blinking state. This transition also leads to a change in the R DC value, which is calculated to be 12, ensuring super blinkogenicity to effectively suppress background signals in living cells. HM-DS655-Halo was successfully applied in dynamic SMLM imaging of diverse intracellular sub-structures with minimal background noise, including mitochondrial fission and contact, cell migration, and pseudopod growth.}, archive = {J_ANGEW}, author = {Qinglong Qiao and Aoxuan Song and Kai An and Ning Xu and Wenhao Jia and Yiyan Ruan and Pengjun Bao and Yi Tao and Yinchan Zhang and Xiang Wang and Zhaochao Xu}, doi = {10.1002/anie.202417469}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417469}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spontaneously blinkogenic probe for wash-free single-molecule localization-based super-resolution imaging in living cells}, volume = {64}, year = {2025}, }
• (2025). High charge carrier mobility in porphyrin nanoribbons. ANGEW, 64(6), e202417429. (www)

  @article{ , abstract = {Polydisperse edge-fused nickel(II) porphyrin nanoribbons have been synthesized by Yamamoto coupling followed by gold(III)-mediated fusion, with average degrees of polymerization of up to 37 repeat units (length 31 nm). Time-resolved optical-pump terahertz spectroscopy measurements indicate that photo-generated charge carriers have dc mobilities of up to 205 cm 2 V −1 s −1 in these nanoribbons, exceeding the values previously reported for most other types of nanoribbon or π-conjugated polymer.}, archive = {J_ANGEW}, author = {He Zhu and Guanzhao Wen and Wenhao Zheng and Nicholas H. Rees and Wojciech Stawski and Hai I. Wang and Mischa Bonn and Harry L. Anderson}, doi = {10.1002/anie.202417429}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417429}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High charge carrier mobility in porphyrin nanoribbons}, volume = {64}, year = {2025}, }
• (2025). Ni(0)-catalyzed rearrangement of vinylcyclobutanones (VCBOs) to synthesize six-membered non-conjugated enones. ANGEW, 64(6), e202417407. (www)

  @article{ , abstract = {We report here the first nickel-catalyzed rearrangement of vinylcyclobutanones (VCBOs) under mild conditions to synthesize non-conjugated cyclohexenone derivatives, which so far do not have many ways to be accessed. The reaction exhibits a wide substrate scope with reaction yields up to 98 %. This VCBO rearrangement can also be used to access various n/6 ( n =5–8) bicyclic products efficiently. Furthermore, mechanism of this rearrangement has been investigated using DFT calculations, showing that vinyl group-assisted cyclobutanone C−C cleavage is easy with a computed activation free energy of 18.1 kcal/mol.}, archive = {J_ANGEW}, author = {Jiguo Ma and Jicheng Duan and Zhi-Xiang Yu}, doi = {10.1002/anie.202417407}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417407}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ni(0)-catalyzed rearrangement of vinylcyclobutanones (VCBOs) to synthesize six-membered non-conjugated enones}, volume = {64}, year = {2025}, }
• (2025). Integrated catalyst ZnNC⊂PtZn for high-performance ethanol electrooxidation and DEFC. ANGEW, 64(6), e202417406. (www)

  @article{ , abstract = {We report here an electrocatalyst that exhibits superior performance in the electrooxidation of ethanol. The reactive centers of the catalyst have a nest-type configuration with outer Zn-N x C nest covering inner PtZn intermetallic compound nanoparticles loaded on carbon support (ZnNC⊂PtZn/C). The high-energy stepped facets of the inner PtZn nanoparticles confined and shaped by the outer Zn-N x C nest is highly active for the critical C−C bond cleavage of ethanol in oxidation, confirmed by experimental characterizations and density functional theory calculations. The catalyst shows a rare high-performance and demonstrates a mass activity of 3.7 A mg Pt −1 and a Faradaic efficiency of 78.2 %, following the C1 pathway of reaction and the retention of initial activity remains 97 % after 5,000 cycles. The unique configuration, also mitigating the concentration polarization, endows the catalyst with innate ethanol electrooxidation property by inner-outer synergic interactions, leading to unexpected power output of an acidic direct ethanol fuel cell.}, archive = {J_ANGEW}, author = {Xiaoxia Hou and Chenjia Liang and Ruiyao Zhao and Liwen Wang and Teng Chen and Jie Yang and Xiangke Guo and Nianhua Xue and Tao Wang and Luming Peng and Xiaomei Zhao and Weiping Ding}, doi = {10.1002/anie.202417406}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417406}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated catalyst ZnNC⊂PtZn for high-performance ethanol electrooxidation and DEFC}, volume = {64}, year = {2025}, }
• (2025). Oxenoid reactivity enabled by targeted photoactivation of periodate. ANGEW, 64(6), e202417402. (www)

  @article{ , abstract = {The chemistry of low-valent intermediates continues to inspire new modes of reactivity across synthetic chemistry. But while the generation and reactivity of both carbenes and nitrenes are well-established, difficulties in accessing oxene, their oxygen-based congener, has severely hampered its application in synthesis. Here, we report a conceptually novel approach towards oxenoid reactivity through the violet-light photolysis of tetrabutylammonium periodate. Computational studies reveal an unexpected geometric change upon periodate photoexcitation that facilitates intersystem crossing and near-barrierless dissociation of triplet periodate into oxene. Under these operationally simple conditions, we have demonstrated the epoxidation of a wide range of substituted olefins, revealing unprecedented functional group compatibility. By overcoming the historic challenges associated with employing oxene as an intermediate in organic chemistry, we believe that this platform will inspire the development of new reactive oxygen-based methodologies across industry and academia.}, archive = {J_ANGEW}, author = {Andre Bossonnet and Ruth A. Garner and James O'Brien and Cristina Trujillo and Aaron D. Trowbridge}, doi = {10.1002/anie.202417402}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxenoid reactivity enabled by targeted photoactivation of periodate}, volume = {64}, year = {2025}, }
• (2025). Near-infrared room-temperature phosphorescence from monocyclic luminophores. ANGEW, 64(6), e202417397. (www)

  @article{ , abstract = {Compact luminophores with long emission wavelengths have aroused considerable theoretical and practical interest. Organics with room-temperature phosphorescence (RTP) are also desirable for their longer lifetimes and larger Stokes shifts than fluorescence. Utilizing the low electronic transition energy intrinsic to thiocarbonyl compounds, electron-withdrawing groups were attached to the 4 H -pyran-4-thione core to further lower the excited state energies. The resulting mini-phosphors were doped into suitable polymer matrices. These purely organic, amorphous materials emitted near-infrared (NIR) RTP. Having a molar mass of only 162 g mol −1 , one of the phosphors emitted RTP that peaked at 750 nm, with a very large Stokes shift of 15485 cm −1 (403 nm). Thanks to the good processability of the polymer film, light-emitting diodes (LEDs) with NIR emission were easily fabricated by coating doped polymer on ultraviolet LEDs. This work provides an intriguing strategy to achieve NIR RTP using compact luminophores.}, archive = {J_ANGEW}, author = {Zi-Ang Yan and Chenjia Yin and He Tian and Xiang Ma}, doi = {10.1002/anie.202417397}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417397}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared room-temperature phosphorescence from monocyclic luminophores}, volume = {64}, year = {2025}, }
• (2025). An angstrom-scale protective skin grown in situ on perovskite oxide to enhance stability in water. ANGEW, 64(6), e202417360. (www)

  @article{ , abstract = {The utilization of perovskite oxide as a catalyst for aqueous reactions is promising but challenging in stability. Here, we propose an in situ growth strategy that constructs an ultrathin protective skin on the Sr 0.9 Fe 0.81 Ta 0.09 Ni 0.1 O 3-δ perovskite surface and thus effectively solves the stability issue. Using a spherical aberration-corrected transmission electron microscope, we observe the coexistence of an angstrom-scale (~7 Å) Fe 2 O 3 protective skin and FeNi alloy nanoparticles. A number of alloy nanoparticles grow along with the skin and uniformly take root on the skin surface. Such a hierarchical structure can reconstruct the surface electronic structure and suppress the ion leaching of perovskite oxide in water. Benefiting from this unique structure, the catalyst has experienced a substantial increase (800 h, more than three orders of magnitude) in its stable operation time in water (for example, in a hydrogen evolution reaction). These results provide valuable insight into solid-solid phase transitions and have substantial implications for using structural defects at surfaces to modulate mass transport and transformation kinetics. Our strategy is sufficiently simple and can be used to subtly manipulate the catalyst structures to improve the performance of perovskite-based catalysts and potentially other oxide catalysts for a wide range of reactions.}, archive = {J_ANGEW}, author = {Wanglin Zhou and Fang Xu and Jinkun Tan and Zhengkun Liu and Guangru Zhang and Zhi Xu and Yinong Lyu and Wanqin Jin}, doi = {10.1002/anie.202417360}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417360}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An angstrom-scale protective skin grown in situ on perovskite oxide to enhance stability in water}, volume = {64}, year = {2025}, }
• (2025). Programming the dynamic range of nanochannel biosensors for MicroRNA detection through allosteric DNA probes. ANGEW, 64(6), e202417280. (www)

  @article{ , abstract = {Solid-state nanochannel biosensors are extensively utilized for microRNA (miRNA) detection owing to their high sensitivity and rapid response. However, conventional nanochannel biosensors face limitations in their fixed dynamic range, restricting their versatility and efficacy. Herein, we introduce tunable triblock DNA probes with varying affinities for target miRNA to engineer solid-state nanochannel biosensors capable of customizable dynamic range adjustment. The triblock DNA architecture comprises a poly-adenine (polyA) block for adjustable surface density anchoring, alongside stem and loop blocks for modulating structural stability. Through systematic manipulation of these blocks, we demonstrate the ability to achieve diverse target binding affinities and detection limits, achieving an initial 81-fold dynamic range. By combining probes with various affinities, we extend this dynamic range significantly to 10,900-fold. Furthermore, by implementing a sequestration mechanism, the effective dynamic range of the nanochannel biosensor is narrowed to only a 3-fold span of target concentrations. The customizable dynamic range of these advanced nanochannel biosensors makes them highly promising for a broad spectrum of biomedical and clinical applications.}, archive = {J_ANGEW}, author = {Zhiwei Shang and Defang Ding and Zixuan Deng and Jing Zhao and Mengyu Yang and Yuling Xiao and Wenjing Chu and Shijun Xu and Zhicheng Zhang and Xiaoqing Yi and Meihua Lin and Fan Xia}, doi = {10.1002/anie.202417280}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417280}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programming the dynamic range of nanochannel biosensors for MicroRNA detection through allosteric DNA probes}, volume = {64}, year = {2025}, }
• (2025). Boosting adsorption and selectivity of acetylene by nitro functionalisation in Copper(II)-based Metal–Organic frameworks. ANGEW, 64(6), e202417183. (www)

  @article{ , abstract = {Purification and storage of acetylene (C 2 H 2 ) are important to many industrial processes. The exploitation of metal–organic framework (MOF) materials to address the balance between selectivity for C 2 H 2 vs carbon dioxide (CO 2 ) against maximising uptake of C 2 H 2 has attracted much interest. Herein, we report that the synergy between unsaturated Cu(II) sites and functional groups, fluoro (−F), methyl (−CH 3 ), nitro (−NO 2 ) in a series of isostructural MOF materials MFM-190(R) that show exceptional adsorption and selectivity of C 2 H 2 . At 298 K, MFM-190(NO 2 ) exhibits an C 2 H 2 uptake of 216 cm 3 g −1 (320 cm 3 g −1 at 273 K) at 1.0 bar and a high selectivity for C 2 H 2 /CO 2 (up to ~150 for v/v = 2/1) relevant to that in the industrial cracking stream. Dynamic breakthrough studies validate and confirm the excellent separation of C 2 H 2 /CO 2 by MFM-190(NO 2 ) under ambient conditions. In situ neutron powder diffraction reveals the cooperative binding, packing and selectivity of C 2 H 2 by unsaturated Cu(II) sites and free −NO 2 groups.}, archive = {J_ANGEW}, author = {Lixia Guo and Xue Han and Jiangnan Li and Weiyao Li and Yinlin Chen and Pascal Manuel and Martin Schröder and Sihai Yang}, doi = {10.1002/anie.202417183}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417183}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting adsorption and selectivity of acetylene by nitro functionalisation in Copper(II)-based Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Revealing intrinsic free charge generation: Promoting the construction of over 19% efficient planar p-n heterojunction organic solar cells. ANGEW, 64(6), e202417143. (www)

  @article{ , abstract = {Due to high binding energy and extremely short diffusion distance of Frenkel excitons in common organic semiconductors at early stage, mechanism of interface charge transfer-mediated free carrier generation has dominated the development of bulk heterojunction (BHJ) organic solar cells (OSCs). However, considering the advancements in materials and device performance, it is necessary to reexamine the photoelectric conversion in current-stage efficient OSCs. Here, we propose that the conjugated materials with specific three-dimensional donor-acceptor conjugated packing potentially exhibit distinctive charge photogeneration mechanism, which spontaneously split Wannier-Mott excitons to free carriers in pure phases. Subsequently, the pure planar p-n heterojunction (PHJ) OSCs based on green orthogonal solvents were prepared and exhibited comparable even greater performance to that of BHJ OSCs. More interestingly, by introducing PVDF-TrFE as intrinsic region to regulate built-in electric field of the device, the planar p-i-n PHJ OSCs achieved much higher efficiency (>18%) and stability. Moreover, a prominent efficiency of over 19% has been obtained via ternary optimization, which is the new efficiency record for PHJ OSCs up to date. This study points towards the distinguishing intrinsic free charge generation mechanism, opens up a new avenue for OSCs to collectively realize high-efficiency, long-term duration, and simplified device engineering for future commercialization.}, archive = {J_ANGEW}, author = {Junjie Wang and Yonghai Li and Fuzhen Bi and Chunpeng Yang and Maria Vasilopoulou and Junhao Chu and Xichang Bao}, doi = {10.1002/anie.202417143}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417143}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing intrinsic free charge generation: Promoting the construction of over 19% efficient planar p-n heterojunction organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Germylene mediated reductive C−C and C−N coupling of an isocyanide and its device application. ANGEW, 64(6), e202417052. (www)

  @article{ , abstract = {We have demonstrated a unique reductive coupling of 4-iodophenyl isocyanide, facilitated by a perimidine-based N-heterocyclic germylene (NHGe), which yields a bis-spirogerma compound featuring simultaneous C−C and C−N bond formation. This reaction, which leads to the oxidation of germanium from +2 to +4, represents a significant departure from previously documented isocyanide-germylene interactions. The product exhibits extensive conjugation across its bicyclic C 4 Ge 2 N 2 framework, conferring distinct photophysical properties, including prominent orange luminescence in both solution and solid states. The photophysical properties are supported by the TD-DFT calculations confirming an n→π* transition. The potential application of this compound in optoelectronic devices, particularly as a hole transport layer in PbS quantum dot solar cells, is also explored, with promising preliminary results.}, archive = {J_ANGEW}, author = {Kritika Gour and Debjit Pramanik and Soumya Ranjan Dash and Dipak Dattatray Shinde and Geethu Venugopal and Kumar Vanka and Arup K. Rath and Sakya S. Sen}, doi = {10.1002/anie.202417052}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417052}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Germylene mediated reductive C−C and C−N coupling of an isocyanide and its device application}, volume = {64}, year = {2025}, }
• (2025). Modular synthesis of dehydroprolines by an energy-transfer enabled cloke-wilson rearrangement. ANGEW, 64(6), e202417025. (www)

  @article{ , abstract = {A one-pot photocatalytic method is reported for the generation of dehydroprolines, valuable precursors to 5-aryl prolines. Imines, obtained via simple condensation of aminocyclopropane carboxylates (ACPC) with a broad range of aldehydes, were employed in this transformation without purification. We demonstrate this energy-transfer (EnT) enabled Cloke-Wilson-type rearrangement affords both the rare 1,2-dehydroprolines or the more thermodynamically favored 1,5-isomers with up to >20 : 1 selectivity in both directions, using an identical catalytic system from the same starting material. Syntheses of intermediates of bioactive molecules in high yields and selectivity highlight this enabling transformation. Mechanistic studies support the proposed triplet-triplet EnT mode of activation, distinct from the previously developed singlet excited states accessed via UV excitation.}, archive = {J_ANGEW}, author = {Austin D. Marchese and Tomislav Rovis}, doi = {10.1002/anie.202417025}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202417025}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular synthesis of dehydroprolines by an energy-transfer enabled cloke-wilson rearrangement}, volume = {64}, year = {2025}, }
• (2025). Azadihomocorannulene as a heptagon-embedded diradicaloid. ANGEW, 64(6), e202416654. (www)

  @article{ , abstract = {Polycyclic aromatic diradical(oid) molecules are attracting significant attention because of their unique electronic and magnetic properties as well as their applications as functional materials. While diradical(oid) molecules bearing five-membered rings have been extensively investigated, those bearing seven-membered rings are relatively fewer. Herein, we report the synthesis of azapentabenzodihomocorannulene dication and diradical molecules. The synthesis was achieved through a mechanochemical C(sp 2 )−H/C(sp 3 )−H coupling in the presence of sodium as a key reaction. Electron spin resonance studies revealed that the neutral azapentabenzodihomocorannulene adopts a singlet diradical (diradicaloid) ground state with a small singlet−triplet energy gap of 2.1 kcal/mol. The electronic and optical properties were investigated both experimentally and theoretically to elucidate their aromatic character.}, archive = {J_ANGEW}, author = {Yosuke Hamamoto and Weifan Wang and Yongxin Li and Shingo Ito}, doi = {10.1002/anie.202416654}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202416654}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Azadihomocorannulene as a heptagon-embedded diradicaloid}, volume = {64}, year = {2025}, }
• (2025). Localized oxidative catalytic reactions triggered by cavitation bubbles confinement on copper oxide microstructured particles.. ANGEW, 64(6), e202416543. (www)

  @article{ , abstract = {Efficient energy transfer management in catalytic processes is crucial for overcoming activation energy barriers while minimizing costs and CO 2 emissions. We exploit here a concept of CuO particle design with multiple gas-stabilizing sites, engineered to function as cavitation nuclei and catalysts. This concept facilitates the selective and efficient acoustic energy transfer directly to the catalyst surface, avoiding the undesired dissipation of acoustic energy into the bulk solution while demonstrating superior cavitation properties at lower acoustic pressure amplitudes. Utilizing a chemical thermometric approach, we demonstrate that the local temperature on the surface of our CuO particles during cavitation bubble implosions can create an effective equivalent temperature of about 360 °C. This temperature effect facilitates the efficient catalysis of oxidative reactions using an organic pollutant probe molecule. Density functional theory (DFT) calculations were used to assess the decomposition of H 2 O 2 and of pollutant probe molecule on CuO (111). Our work represents a significant advance in sonocatalytic systems, promising efficient energy use in catalytic reactions.}, archive = {J_ANGEW}, author = {Valarmathi Mahendran and Quang Thang Trinh and Xie Zhangyue and Umesh Jonnalagadda and Tim Gould and Nam-Trung Nguyen and James Kwan and Tej S. Choksi and Wen Liu and Sabine Valange and François Jérôme and Prince Nana Amaniampong}, doi = {10.1002/anie.202416543}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202416543}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Localized oxidative catalytic reactions triggered by cavitation bubbles confinement on copper oxide microstructured particles.}, volume = {64}, year = {2025}, }
• (2025). Photoredox/Cobalt-catalyzed chemo-, regio-, diastereo- and enantioselective reductive coupling of 1,1-disubstituted allenes and cyclobutenes. ANGEW, 64(6), e202416524. (www)

  @article{ , abstract = {A dual photoredox/cobalt-catalyzed protocol for chemo-, regio-, diastereo- and enantioselective reductive coupling of 1,1-disubstituted allenes and cyclobutenes through chemo-, regio-, diastereo- and enantioselective oxidative cyclization followed by stereoselective protonation promoted by a chiral phosphine–cobalt complex is presented. Such process represents an unprecedented reaction pathway for cobalt catalysis that enables selective transformation of the less sterically congested alkenes of 1,1-disubstituted allenes with cyclobutenes, incorporating a broad scope of tetrasubstituted alkenes into the cyclobutane scaffolds in up to 86 % yield, >98 : 2 chemo- and regioselectivity, >98 : 2 dr and >99.5:0.5 er. Functionalization delivered a variety of enantioenriched cyclobutanes that are otherwise difficult to access. Preliminary mechanistic studies revealed that the reactions proceeded through oxidative cyclization followed by protonation and protonation might be the rate-determining step.}, archive = {J_ANGEW}, author = {Qianghui Wu and Zhihan Zhang and Qinglei Chong and Fanke Meng}, doi = {10.1002/anie.202416524}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202416524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoredox/Cobalt-catalyzed chemo-, regio-, diastereo- and enantioselective reductive coupling of 1,1-disubstituted allenes and cyclobutenes}, volume = {64}, year = {2025}, }
• (2025). Single-atom catalysts on C3N4: Minimizing single atom pt loading for maximized photocatalytic hydrogen production efficiency. ANGEW, 64(6), e202416453. (www)

  @article{ , abstract = {The use of metal single atoms (SAs) as co-catalysts on semiconductors has emerged as a promising technology to enhance their photocatalytic hydrogen production performance. In this study, we describe the deposition of very low amounts of Pt SAs (<0.1 at %) on exfoliated graphitic carbon nitride (C 3 N 4 ) by a direct Pt−deposition approach from highly dilute chloroplatinic acid precursors. We find that − using this technique−a remarkably low loading of highly dispersed Pt SAs (0.03 wt %) on C 3 N 4 is sufficient to achieve a drastic decrease in the overall charge transfer resistance and a maximized photocatalytic efficiency. The resulting low-loaded Pt SAs/C 3 N 4 provides a H 2 production rate of 1.66 m mol/h/mg Pt, with a remarkable stability against agglomeration; even during prolonged photocatalytic reactions no sign of light-induced Pt agglomerations can be observed. We ascribe the high performance and stability to the site-selective, stable coordination of Pt within the C 3 N 4 structure. Notably the H 2 production rate of the low-loaded Pt SAs surpasses the activity of Pt SAs deposited by other techniques or nanoparticles at comparable or even higher loading – the optimized Pt SAs decorated C 3 N 4 show ≈5.9 times higher rate than Pt NP decorated C 3 N 4 .}, archive = {J_ANGEW}, author = {Nawres Lazaar and Siming Wu and Shanshan Qin and Abdessalem Hamrouni and Bidyut Bikash Sarma and Dimitry E. Doronkin and Nikita Denisov and Hinda Lachheb and Patrik Schmuki}, doi = {10.1002/anie.202416453}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202416453}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-atom catalysts on C3N4: Minimizing single atom pt loading for maximized photocatalytic hydrogen production efficiency}, volume = {64}, year = {2025}, }
• (2025). Total syntheses of β- and γ-naphthocyclinones. ANGEW, 64(6), e202415108. (www)

  @article{ , abstract = {After half a century from their isolation in 1974, we report the first total syntheses of β- and γ-naphthocyclinones, two dimeric pyranonaphthoquinones featuring an unusual bicyclo[3.2.1]octadienone core. The syntheses were achieved with full stereochemical control and functional group management, relying on 1) enantioselective construction of the bicyclic core by Rh-catalyzed enantioselective 1,4-addition followed by thiolate-mediated reductive cyclization, and 2) judicious design of a common chiral, non-racemic monomer unit that is capable of divergence into the donor and acceptor units, and reunion to construct the bicyclo[3.2.1]octadienone core.}, archive = {J_ANGEW}, author = {Yoshio Ando and Taiju Hoshino and Nozomi Tanaka and Mark M. Maturi and Yusuke Nakazawa and Takumi Fukazawa and Ken Ohmori and Keisuke Suzuki}, doi = {10.1002/anie.202415108}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202415108}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total syntheses of β- and γ-naphthocyclinones}, volume = {64}, year = {2025}, }
• (2025). Fragment discovery by X-ray crystallographic screening targeting the CTP binding site of pseudomonas aeruginosa IspD. ANGEW, 64(6), e202414615. (www)

  @article{ , abstract = {With antimicrobial resistance (AMR) reaching alarming levels, new anti-infectives with unprecedented mechanisms of action are urgently needed. The 2- C -methylerythritol-D-erythritol-4-phosphate (MEP) pathway represents an attractive source of drug targets due to its essential role in numerous pathogenic Gram-negative bacteria and Mycobacterium tuberculosis ( Mt ), whilst being absent in human cells. Here, we solved the first crystal structure of Pseudomonas aeruginosa ( Pa ) IspD, the third enzyme in the MEP pathway and present the discovery of a fragment-based compound class identified through crystallographic screening of Pa IspD. The initial fragment occupies the CTP binding cavity within the active site. Confirmation of fragment–protein interactions was achieved through 1 H saturation–transfer difference nuclear magnetic resonance ( 1 H-STD NMR spectroscopy). Building upon these findings and insights from the co-crystal structures, we identified two growth vectors for fragment growing. We synthesized derivatives addressing both growth vectors, which showed improved affinities for Pa IspD. Our new fragment class targets Pa IspD, displays promising affinity and favorable growth vectors for further optimization.}, archive = {J_ANGEW}, author = {Daan Willocx and Lucia D'Auria and Danica Walsh and Hugo Scherer and Alaa Alhayek and Mostafa M. Hamed and Franck Borel and Eleonora Diamanti and Anna K. H. Hirsch}, doi = {10.1002/anie.202414615}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202414615}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fragment discovery by X-ray crystallographic screening targeting the CTP binding site of pseudomonas aeruginosa IspD}, volume = {64}, year = {2025}, }
• (2025). Synthesis of low-molecular-weight fucoidan analogue and its inhibitory activities against heparanase and SARS-CoV-2 infection. ANGEW, 64(6), e202411760. (www)

  @article{ , abstract = {Heparan sulfate (HS) is ubiquitous on cell surfaces and is used as a receptor by many viruses including SARS-CoV-2. However, increased activity of the inflammatory enzyme heparanase (HPSE), which hydrolyses HS, in patients with COVID-19 not only increases the severity of symptoms but also may facilitate the spread of the virus by degrading HS on the cell surface. Therefore, synthetic HPSE blockades, which can bind to SARS-CoV-2 spike protein (SARS-CoV-2-S) and inhibit viral entry, have attracted much attention. This study investigated the development of a new dual-targeting antiviral agent against HPSE and SARS-CoV-2-S using fucoidan as a structural motif. It was found that all-sulfated fucoidan derivative 10 , which exhibited the highest binding affinity to SARS-CoV-2-S among 13 derivatives, also showed the highest inhibitory activity against HPSE. Based on this, a newly designed and synthesized fucoidan analogue 16 , in which the octyl group of 10 was changed to a cholestanyl group, was found to show approximately 3 times higher activity than 10 but did not inhibit factor Xa associated with undesired anticoagulant effects. The binding affinity of 16 to SARS-CoV-2-S was significantly increased approximately 400-fold over that of 10 . The binding of 16 to SARS-CoV-2-S inhibited the binding between SARS-CoV-2-S and heparin and between SARS-CoV-2-S and ACE2. Furthermore, 16 effectively inhibited infection by the SARS-CoV-2 Wuhan strain and two Omicron subvariants.}, archive = {J_ANGEW}, author = {Aoi Sugimoto and Tatsuki Koike and Yuya Kuboki and Sumika Komaba and Shuhei Kosono and Maniyamma Aswathy and Itsuki Anzai and Tokiko Watanabe and Kazunobu Toshima and Daisuke Takahashi}, doi = {10.1002/anie.202411760}, journal = {Angewandte Chemie International Edition}, month = {2}, number = {6}, pages = {e202411760}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of low-molecular-weight fucoidan analogue and its inhibitory activities against heparanase and SARS-CoV-2 infection}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Microfluidic precision manufacture of high performance liquid chromatographic microspheres. ANGEW, 64(5), e202580562. (www)

  @article{ , archive = {J_ANGEW}, author = {Kaiyue Sun and Juxing Zeng and Ya Liu and Zhuoheng Zhou and Jikai Chen and Jiawei Chen and Xiangyu Huang and Fan Gao and Xin Wang and Xin Zhang and Xiaofei Wang and Sebastiaan Eeltink and Bo Zhang}, doi = {10.1002/anie.202580562}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202580562}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Microfluidic precision manufacture of high performance liquid chromatographic microspheres}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Orientational compatibility modulation of ligands in low-symmetry multi-cavity discrete coordination cages by neighbouring cage participation. ANGEW, 64(5), e202580561. (www)

  @article{ , archive = {J_ANGEW}, author = {Ashish Kumar and Shobhana Krishnaswamy and Dillip Kumar Chand}, doi = {10.1002/anie.202580561}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202580561}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Orientational compatibility modulation of ligands in low-symmetry multi-cavity discrete coordination cages by neighbouring cage participation}, volume = {64}, year = {2025}, }
• (2025). Edmundo g. percástegui. ANGEW, 64(5), e202424358. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202424358}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202424358}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Edmundo g. percástegui}, volume = {64}, year = {2025}, }
• (2025). Lucas foppa. ANGEW, 64(5), e202424015. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202424015}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202424015}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lucas foppa}, volume = {64}, year = {2025}, }
• (2025). Back cover: Opening the hysteresis loop in ferromagnetic Fe3GeTe2 nanosheets through functionalization with TCNQ molecules (Angew. chem. int. ed. 5/2025). ANGEW, 64(5), e202423475. (www)

  @article{ , archive = {J_ANGEW}, author = {Govind Sasi Kumar and Alberto M. Ruiz and Jaime Garcia-Oliver and Yan Xin and José J. Baldoví and Michael Shatruk}, doi = {10.1002/anie.202423475}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202423475}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Opening the hysteresis loop in ferromagnetic Fe3GeTe2 nanosheets through functionalization with TCNQ molecules (Angew. chem. int. ed. 5/2025)}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Transforming aryl-tetrazines into bioorthogonal scissors for systematic cleavage of trans-cyclooctenes (Angew. chem. int. ed. 5/2025). ANGEW, 64(5), e202423133. (www)

  @article{ , archive = {J_ANGEW}, author = {Martin Wilkovitsch and Walter Kuba and Patrick Keppel and Barbara Sohr and Andreas Löffler and Stefan Kronister and Andres Fernandez del Castillo and Marion Goldeck and Rastislav Dzijak and Michal Rahm and Milan Vrabel and Dennis Svatunek and Jonathan C. T. Carlson and Hannes Mikula}, doi = {10.1002/anie.202423133}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202423133}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Transforming aryl-tetrazines into bioorthogonal scissors for systematic cleavage of trans-cyclooctenes (Angew. chem. int. ed. 5/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Affecting charges and structures of {Bi6} architectures by 12-electron transition metal fragments (Angew. chem. int. ed. 5/2025). ANGEW, 64(5), e202422500. (www)

  @article{ , archive = {J_ANGEW}, author = {Andreas Schmidt and Julia Rienmüller and Florian Weigend and Stefanie Dehnen}, doi = {10.1002/anie.202422500}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202422500}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Affecting charges and structures of {Bi6} architectures by 12-electron transition metal fragments (Angew. chem. int. ed. 5/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Controlled helical organization in supramolecular polymers of pseudo-macrocyclic tetrakisporphyrins (Angew. chem. int. ed. 5/2025). ANGEW, 64(5), e202422484. (www)

  @article{ , archive = {J_ANGEW}, author = {Naoka Fujii and Naoyuki Hisano and Takehiro Hirao and Shin-ichi Kihara and Kouta Tanabe and Masaya Yoshida and Shin-ichi Tate and Takeharu Haino}, doi = {10.1002/anie.202422484}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202422484}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Controlled helical organization in supramolecular polymers of pseudo-macrocyclic tetrakisporphyrins (Angew. chem. int. ed. 5/2025)}, volume = {64}, year = {2025}, }
• (2025). Carbon dioxide upgrading to biodegradable plastics through Photo/Electro-synthetic biohybrid systems. ANGEW, 64(5), e202422357. (www)

  @article{ , abstract = {The escalating emissions of anthropogenic carbon dioxide (CO 2 ) and the pervasive issue of nondegradable plastic pollution underscore dual urgent challenges in pursuit of a sustainable society. Achieving such sustainability in the plastic industry, while effectively addressing these environmental concerns, necessitates the development and implementation of innovative strategies for the synthesis of biodegradable polymers utilizing CO 2 as feedstocks. The technologies not only facilitate the mitigation of elevated atmospheric CO 2 concentrations but also introduce a renewable carbon resource for polymer manufacturing. While considerable research has been undertaken in CO 2 upgrading to various C 1-3 products, the production of biodegradable polymers from CO 2 remains a formidable challenge. Here, we delineate the principal methodologies for catalytic CO 2 upgrading to biodegradable polymers, encompassing photocatalytic-biological processes and electrocatalytic-biological approaches. The emphasis of this perspective is on the optimization of production processes and catalyst efficiency, which are paramount in addressing the imperative challenge of decarbonization in the plastic industry, thereby aligning with global environmental sustainability goals.}, archive = {J_ANGEW}, author = {Min Kuang and Bingbing Li and Linjiao Zhou and Zichao Huang and Jing Wu and Shaobin Wang and Jianping Yang}, doi = {10.1002/anie.202422357}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202422357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon dioxide upgrading to biodegradable plastics through Photo/Electro-synthetic biohybrid systems}, volume = {64}, year = {2025}, }
• (2025). Covalent folding of fluorinated polyphenylene by sulfur fluorine annulative substitution. ANGEW, 64(5), e202420073. (www)

  @article{ , abstract = {We report that fluorinated polyphenylene P50 undergoes folding-like sulfur fluorine annulative substitution (SFAS) to form a well-defined tubular helix H50 . This is achieved with atomic precision in an exceptionally efficient manner, involving the simultaneous transformation of 98 C−F bonds with the yield per reaction site approaching 99.9 %. The desired product H50 features a fully fused dibenzothiophene skeleton of 5.8 helical turns in total. It is truly monodisperse ( Đ =1.0) in nature, allowing for thorough spectroscopic characterizations. Unambiguous single crystal X-ray structure, distinct chiroptical properties, and intriguing through-cavity threading complexation are described. These results, in addition to those of H50 ’s lower congeners, H34 and H18 , illustrate the great potential of folding-like SFAS in shaping random-coiled polymer chains into higher-order functional structures.}, archive = {J_ANGEW}, author = {Yanpeng Zhu and Chaojun Lin and Chaoqun Zhao and Yiqiang Ou and Zhongshu Li and Kelong Zhu and Jiaobing Wang}, doi = {10.1002/anie.202420073}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202420073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent folding of fluorinated polyphenylene by sulfur fluorine annulative substitution}, volume = {64}, year = {2025}, }
• (2025). Self-immolative polymers derived from renewable resources via Thiol–Ene chemistry**. ANGEW, 64(5), e202420054. (www)

  @article{ , abstract = {The development of polymers from renewable resources is a promising approach to reduce reliance on petrochemicals. In addition, depolymerization is attracting significant attention for the breakdown of polymers at their end-of-life or to achieve specific stimuli-responsive functions. However, the design of polymers incorporating both of these features remains a challenge. Herein, we report a new class of self-immolative polymers based on lignin-derived aldehydes via a simple thiol-ene polymerization. These self-immolative polymers undergo cascade degradation in response to specific stimuli through alternating 1,6-elimination and cyclization reactions. The two methoxy substituents on the syringaldehyde monomer accelerated the desired depolymerization reaction, while enhancing stability against undesired backbone hydrolysis. Moreover, diverse responsive end-caps could be introduced through post-polymerization functionalization from a single polymer precursor.}, archive = {J_ANGEW}, author = {Zhengyu Deng and Elizabeth R. Gillies}, doi = {10.1002/anie.202420054}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202420054}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-immolative polymers derived from renewable resources via Thiol–Ene chemistry**}, volume = {64}, year = {2025}, }
• (2025). Pooled nanoparticle screening using a chemical barcoding approach. ANGEW, 64(5), e202420052. (www)

  @article{ , abstract = {We report the development of a small molecule-based barcoding platform for pooled screening of nanoparticle delivery. Using aryl halide-based tags (halocodes), we achieve high-sensitivity detection via gas chromatography coupled with mass spectrometry or electron capture. This enables barcoding and tracking of nanoparticles with minimal halocode concentrations and without altering their physicochemical properties. To demonstrate the utility of our platform for pooled screening, we synthesized a halocoded library of polylactide-co-glycolide (PLGA) nanoparticles and quantified uptake in ovarian cancer cells in a pooled manner. Our findings correlate with conventional fluorescence-based assays. Additionally, we demonstrate the potential of halocodes for spatial mapping of nanoparticles using mass spectrometry imaging (MSI). Halocoding presents an accessible and modular nanoparticle screening platform capable of quantifying delivery of pooled nanocarrier libraries in a range of biological settings.}, archive = {J_ANGEW}, author = {Katherine Vaidya and Michael S. Regan and James Lin and Jenna Houle and Aanchal Gupta and Sylwia A. Stopka and Nathalie Y. R. Agar and Paula T. Hammond and Natalie Boehnke}, doi = {10.1002/anie.202420052}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202420052}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pooled nanoparticle screening using a chemical barcoding approach}, volume = {64}, year = {2025}, }
• (2025). Synthesis and functionalization of sulfoximine-bicyclo[1.1.0]butanes: Functionalizable, tuneable and cysteine-selective chiral warheads. ANGEW, 64(5), e202420028. (www)

  @article{ , abstract = {Electrophilic covalent warheads with appropriate reactivity and selectivity are crucial to the investigation of protein function and the discovery of therapeutics. Here we report the synthesis of sulfoximine bicyclo[1.1.0] butanes (BCBs) as novel thiol reactive chiral warheads, achieved in one-pot from methylsulfoximines. Unusually the warhead can then be derivatized, keeping the BCB intact, over 3 vectors: i) sulfoximine N-modification instills a broad range of strain-release reactivity; ii) sp 2 -cross-coupling reactions on aryl-BCB-sulfoximines allows direct diversification, and iii) functionalization of the BCB motif itself is achieved by metalation and trapping with electrophiles. The BCB sulfoximines are shown to react selectively with cysteine including in a protein model (CDK2) under biocompatible conditions. Preliminary data indicate suitability for chemoproteomic applications, and enantioselective cysteine-labelling. The reactivity of sulfoximine BCBs with electron withdrawing groups on nitrogen is comparable to acrylamides with low to moderate reactivity.}, archive = {J_ANGEW}, author = {Zhenhao Zhong and Brad J. W. Hocking and Charles P. Brown and Tsz-Kan Ma and Andrew J. P. White and David J. Mann and Alan Armstrong and James A. Bull}, doi = {10.1002/anie.202420028}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202420028}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and functionalization of sulfoximine-bicyclo[1.1.0]butanes: Functionalizable, tuneable and cysteine-selective chiral warheads}, volume = {64}, year = {2025}, }
• (2025). Rapid, non-invasive, accurate diagnosis and efficient clearance of metastatic lymph nodes. ANGEW, 64(5), e202419988. (www)

  @article{ , abstract = {Sentinel lymph node (SLN) biopsy is currently the standard procedure for clinical cancer diagnosis and treatment, but still faces the risks of false negatives and tumor metastasis, as well as time-consuming pathological evaluation procedure. Herein, we proposed a near-infrared-II (NIR-II, 1000–1700 nm) theranostic nanosystem (FLAGC) for rapid, non-invasive, accurate diagnosis and efficient clearance of metastatic lymph nodes in breast cancer. Initialized by chlorin e6 (Ce6), a pH-sensitive amphiphilic amino acid fluorenylmethoxycarbonyl-L-histidine (Fmoc-His) was assembled with Gd 3+ , luminol, and AgAuSe quantum dots (AAS QDs) to form FLAGC. In FLAGC, luminol and AAS QDs form a NIR-II chemical resonance energy transfer (CRET) system (Luminol-AAS); Ce6 initiates the assembly and also serves as a photosensitizer. Upon subcutaneous injection, FLAGC is easily drained into SLNs, achieving their precise localization. Subsequently, the acidity of tumor microenvironment triggers the rapid disassembly of FLAGC, exposing Luminol-AAS. myeloperoxidase (MPO) secreted by tumor-associated macrophages and neutrophils in SLNs mediates the oxidation of luminol, lighting up AAS QDs through the CRET process for precise diagnosis of metastatic lymph nodes. Moreover, highly efficient clearance of positive lymph nodes is achieved through Ce6-mediated photodynamic therapy. Our strategy provides a new paradigm for identifying and eliminating clinically metastatic lymph nodes.}, archive = {J_ANGEW}, author = {Sisi Ling and Hongchao Yang and Feng Wu and Xiaohu Yang and Tuanwei Li and Yejun Zhang and Jiang Jiang and Chunyan Li and Qiangbin Wang}, doi = {10.1002/anie.202419988}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419988}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid, non-invasive, accurate diagnosis and efficient clearance of metastatic lymph nodes}, volume = {64}, year = {2025}, }
• (2025). Polarity-reversed functionalization of aliphatic aldehydes via divergent nickel hydride catalysis. ANGEW, 64(5), e202419965. (www)

  @article{ , abstract = {Divergent catalysis represents an exciting frontier for unlocking molecular structural diversity and exploring new activation modes. Here, we report the unexpected discovery of polarity-reversed divergent activation and functionalization of aliphatic aldehydes, where enolizable aliphatic aldehydes are selectively activated by nickel hydride to form two distinct alkylnickel intermediates divergently. This mild and operationally simple process enables the transformation of a wide variety of readily available aliphatic aldehydes, along with alkyl or aryl electrophiles, into the corresponding secondary alcohols or more challenging deoxygenated alkanes with excellent chemoselectivity.}, archive = {J_ANGEW}, author = {Changpeng Chen and Hanhong Xu and Shaolin Zhu}, doi = {10.1002/anie.202419965}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419965}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polarity-reversed functionalization of aliphatic aldehydes via divergent nickel hydride catalysis}, volume = {64}, year = {2025}, }
• (2025). Probing the hidden photoisomerization of a symmetric phosphaalkene switch. ANGEW, 64(5), e202419943. (www)

  @article{ , abstract = {In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerization experimentally for the first time. With a combination of photochemical-exchange NMR spectroscopy, ultrafast transient absorption spectroscopy, and quantum chemical calculations, we elucidate the isomerization mechanism of this symmetric phosphaalkene, comparing it to two other known molecules belonging to this class. Our findings highlight the critical role of the isolobal analogy between C=P and C=C bonds in governing nanoscale molecular motion and break new ground for our understanding of light-induced molecular processes in symmetric heteroalkene systems.}, archive = {J_ANGEW}, author = {Rajesh Deka and Jorn D. Steen and Michiel F. Hilbers and Wim G. Roeterdink and Alessandro Iagatti and Ruisheng Xiong and Wybren Jan Buma and Mariangela Di Donato and Andreas Orthaber and Stefano Crespi}, doi = {10.1002/anie.202419943}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419943}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing the hidden photoisomerization of a symmetric phosphaalkene switch}, volume = {64}, year = {2025}, }
• (2025). Late-stage diazoester installation via arylthianthrenium salts. ANGEW, 64(5), e202419931. (www)

  @article{ , abstract = {By leveraging the fast oxidative addition of arylthianthrenium salts (aryl-TT + ) to palladium(0), a regioselective diazoester installation has been developed. This approach enables the introduction of a diazo moiety to densely functionalized arenes at a late stage. The installed diazo group is amenable to facile further derivatization.}, archive = {J_ANGEW}, author = {Le Li and Sven Müller and Roland Petzold and Tobias Ritter}, doi = {10.1002/anie.202419931}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419931}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Late-stage diazoester installation via arylthianthrenium salts}, volume = {64}, year = {2025}, }
• (2025). Dynamic covalent bonds-mediated color-switchable circularly polarized luminescence in helical assemblies of achiral liquid crystal block copolymer films. ANGEW, 64(5), e202419924. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) film attracted considerable attention in information storage and encryption, three-dimensional display, and chiral recognition. However, due to the limited molecular mobility within thin film, achieving a high asymmetry factor and non-contact modulation of CPL remain challenging. In this work, color-switchable homochiral CPL films with high luminescence asymmetry factor (g lum ~0.11) were constructed based on the co-assembly of a liquid crystal block copolymer (poly (ethylene oxide)- b -poly (methyl methacrylate) bearing cyanostilbene group) with axial chiral dinaphthalene diamine derivatives (R/S-DINBPA). Mechanistic investigation revealed that the efficient stacking of R/S-DINBPA with cyanostilbene groups and the liquid crystal field provide the driving force for chiral transfer and amplification. The dynamic covalent bonds of the cyanostilbene groups endow the film with chiral fixation ability and enable precise modulation of CPL luminescence bands under UV light irradiation, making it suitable for chiral patterned anti-counterfeit encryption. This facile strategy provides a general platform for designing intelligent chiroptical materials.}, archive = {J_ANGEW}, author = {Jianan Yuan and Xiaojie He and Lianjie Chen and Xuemin Lu and Qinghua Lu}, doi = {10.1002/anie.202419924}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic covalent bonds-mediated color-switchable circularly polarized luminescence in helical assemblies of achiral liquid crystal block copolymer films}, volume = {64}, year = {2025}, }
• (2025). B12-dependent radical SAM enzymes catalyze C-fluoromethylation via a CH2F-cobalamin intermediate. ANGEW, 64(5), e202419815. (www)

  @article{ , abstract = {Fluorine and fluorine-containing functional groups play important roles in drugs and agrochemicals. Recently, SAM-dependent methyltransferases and several SAM analogues have been reported for fluoromethyl transfer through a nucleophilic mechanism. However, fluoromethylation of unactivated carbon centers is very challenging, and their substitution usually involves a radical mechanism. To date, no biocatalysts have been developed for fluoromethylation of unactivated carbon centers. In this study, we found that the B12-dependent radical SAM methyltransferase (B12-RSMT) QCMT can fluoromethylate the glutamine Cα position of peptides with fluorinated SAM (F-SAM) generated in situ by the enzyme Acl HMT. QCMT can cleave F-SAM to produce the 5'-dA radical. The significant reaction intermediate CH 2 FCbI was characterized by HR-MS, 19 F NMR spectroscopy and X-ray crystallography. In addition, B12-RSMTs CysS and GenD1 can also transfer fluoromethyl groups onto natural products. We also found that F-SAM is not compulsory. The reduced B12-RSMTs can directly generate CH 2 FCbI with CH 2 FI and transfer the CH 2 F group when SAM is used as the radical initiator. Our results demonstrate a radical-mediated enzymatic strategy for fluoromethylation with abiological cofactors and expand radical SAM enzymes to the field of fluorine chemistry.}, archive = {J_ANGEW}, author = {Liyuan Kong and Jianliang Zhang and Haoxin Wang and Zhifeng Wei and Wenrui Wang and Jing Hu and Min Dong}, doi = {10.1002/anie.202419815}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419815}, shortjournal = {Angew. Chem. Int. Edit.}, title = {B12-dependent radical SAM enzymes catalyze C-fluoromethylation via a CH2F-cobalamin intermediate}, volume = {64}, year = {2025}, }
• (2025). Dication disulfuranes as photoactivatable sources of radical organocatalysts. ANGEW, 64(5), e202419751. (www)

  @article{ , abstract = {The recent development of photoredox and energy transfer catalysis has led to a significant expansion of visible-light-driven chemical transformations. These methods have demonstrated exceptional efficiency in converting a wide range of substrates into radical intermediates and generating open-shell catalytic species. However, the simplification of catalytic systems and the direct generation of highly reactive radical organocatalysts through direct visible-light irradiation from stable precatalysts remains largely an unrealized goal. This challenge is mainly due to the limited availability of precatalysts that are responsive to visible light. Herein, we introduce a new class of bench-stable dicationic disulfuranes, which release highly reactive thiyl radicals upon blue-light excitation. Spectroscopic and computational studies reveal that this reactivity arises from a combination of structural features and intermolecular interactions. This family of molecules has been employed to catalyze radical cascades previously incompatible with photoredox conditions, enabling the efficient formation of 1,2-dioxolanes and 1,3-hydroxyketones in excellent yields and short reaction times.}, archive = {J_ANGEW}, author = {Kun-Long Song and Ricardo Meyrelles and Guillaume Pilet and Boris Maryasin and Maurice Médebielle and Jérémy Merad}, doi = {10.1002/anie.202419751}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419751}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dication disulfuranes as photoactivatable sources of radical organocatalysts}, volume = {64}, year = {2025}, }
• (2025). Applicable descriptors under weak metal-oxygen d–p interaction for the oxygen evolution reaction. ANGEW, 64(5), e202419718. (www)

  @article{ , abstract = {The oxygen evolution reaction (OER) plays a crucial role in water electrolysis and renewable energy conversion processes. Descriptors are utilized to elucidate the structure-performance relationships of OER catalytic materials, yet each descriptor exhibits specificity to particular systems. Currently, there is a lack of effective descriptors to describe the relationship between electronic structure and OER performance in ionic systems. This study reveals for the first time that widely used OER descriptors, the d -band center and charge transfer energy, are limited in their effectiveness for oxide systems dominated by ionic bonds, in which ionic interactions significantly enhance or suppress the catalytic activity. Furthermore, composite descriptors tailored for ionic systems are proposed, with findings extended to complex multi-component and high-entropy oxides. The results indicate that the metal d -band unoccupied states parameter and the active states parameter can serve as effective OER descriptors for ionic catalytic materials. This work addresses the gap in OER descriptors for ionic systems, offering a new theoretical foundation and guidance for the development of efficient OER catalytic materials.}, archive = {J_ANGEW}, author = {Fangshi Fan and Bohan Lei and Xiaomin Song and Jiayuan Liang and Weiwei Cai and Yu Zhong and Yongjun Wu and Ningzhong Bao and Lingjie Zhang}, doi = {10.1002/anie.202419718}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419718}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Applicable descriptors under weak metal-oxygen d–p interaction for the oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Electrochemical dicarboxylation of vinyl epoxide with CO2 for the facile and selective synthesis of diacids. ANGEW, 64(5), e202419702. (www)

  @article{ , abstract = {We present a novel electrochemical dicarboxylation of epoxides with CO 2 , characterized by the cleavage of two C−O single bonds. Not only are vinyl epoxides viable, but cyclic carbonates also serve as effective substrates, facilitating the synthesis of E -configured adipic and octanedioic acids with high chemo-, regio-, and stereoselectivity. The synthetic practicality is further highlighted by the diverse functionalizations of the resulting multifunctional diacids. Mechanistic studies support the single-electron transfer reduction of CO 2 to its radical anion, which undergoes radical addition to the vinyl moiety of epoxides. The subsequent reductive cleavage of two C−O bonds, coupled with a nucleophilic attack on CO 2 , culminates in the formation of the desired diacid products.}, archive = {J_ANGEW}, author = {Deyong Yang and Ying Sun and Nan Feng and Yuqing Zhong and Jian Zhou and Feng Zhou}, doi = {10.1002/anie.202419702}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical dicarboxylation of vinyl epoxide with CO2 for the facile and selective synthesis of diacids}, volume = {64}, year = {2025}, }
• (2025). Mimicking the CO2-bound state of the [Ni,Fe]-CO dehydrogenase. ANGEW, 64(5), e202419675. (www)

  @article{ , abstract = {Complexes, where a doubly reduced CO 2 2− (carbonite) ligand is spanned between a nickel(II) centre and a transition metal(II) ion (TM=Fe, Co, Zn) have been accessed. In non-coordinating solvents the carbonite ligand exhibits a flexible coordination behaviour as observed by NMR spectroscopy and supported by DFT calculations. In particular the [Ni-CO 2 -Fe] representative replicates the respective entity in an intermediate formed during CO 2 -conversion by the enzyme [Ni,Fe]-CODH in many ways (structure, spectroscopic properties, reactivity). Our investigations reveal that transition metal ions reduce the reduction potential of the carbonite unit but increase its tendency to undergo C−O bond cleavage. This may explain the choice of an iron(II) ion instead of a s- or p-block-based Lewis acid as part of the active site.}, archive = {J_ANGEW}, author = {Siad Wolff and Arne Hofmann and Konstantin B. Krause and Kilian Weisser and Beatrice. Cula and Thomas Lohmiller and Christian Herwig and Christian Limberg}, doi = {10.1002/anie.202419675}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419675}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mimicking the CO2-bound state of the [Ni,Fe]-CO dehydrogenase}, volume = {64}, year = {2025}, }
• (2025). Two-dimensional catalysts: From model to reality. ANGEW, 64(5), e202419661. (www)

  @article{ , abstract = {Two-dimensional (2D) materials have been utilized broadly in kinds of catalytic reactions due to their fully exposed active sites and special electronic structure. Compared with real catalysts, which are usually bulk or particle, 2D materials have more well-defined structures. With easily identified structure-modulated engineering, 2D materials become ideal models to figure out the catalytic structure-function relations, which is helpful for the precise design of catalysts. In this review, the unique function of 2D materials was summarized from model study to reality catalysis and application. It includes several typical 2D materials, such as graphene, transition metal dichalcogenides, metal, and metal (hydr)oxide materials. We introduced the structural characteristics of 2D materials and their advantages in model researches. It emphatically summarized how 2D materials serve as models to explore the structure-activity relationship by combining theoretical calculations and surface research. The opportunities of 2D materials and the challenges for fundamentals and applications they facing are also addressed. This review provides a reference for the design of catalyst structure and composition, and could inspire the realization of two-dimensional materials from model study to reality application in industry.}, archive = {J_ANGEW}, author = {Mo Zhang and Zifeng Wang and Xin Bo and Rui Huang and Dehui Deng}, doi = {10.1002/anie.202419661}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-dimensional catalysts: From model to reality}, volume = {64}, year = {2025}, }
• (2025). Nanomaterials-induced PANoptosis: A promising anti-tumor strategy. ANGEW, 64(5), e202419649. (www)

  @article{ , abstract = {Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become a critical strategy for cancer treatment. PANoptosis, a newly discovered form of regulated cell death, integrates key molecular components of pyroptosis, apoptosis, and necroptosis, activating these three death pathways simultaneously to achieve synergistic multi-mechanistic killing. PANoptosis significantly inhibits cancer cell growth and resistance and activates strong anti-tumor immune response, making tumor-specific induction of PANoptosis a potential cancer therapeutic strategy. Currently, cancer treatment research related to PANoptosis is focused mainly on the development of small molecules and cytokines. However, these approaches still face limitations in terms of metabolic stability and tumor specificity. The unique physicochemical properties and biological activities of nanomaterials hold significant promise for optimizing PANoptosis induction strategies. This review summarizes the concept and mechanisms of PANoptosis, highlights the latest applications of nanoagents in PANoptosis-based anti-cancer therapy, and discusses the challenges and future directions for clinical translation. It is hoped that this review will inspire further exploration and development of PANoptosis-based cancer treatments, providing new perspectives for researchers in the field.}, archive = {J_ANGEW}, author = {Guanghui Hou and Youdong Chen and Huali Lei and Shunyi Lu and Liang Cheng}, doi = {10.1002/anie.202419649}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419649}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanomaterials-induced PANoptosis: A promising anti-tumor strategy}, volume = {64}, year = {2025}, }
• (2025). Light-responsive aldehyde-reduction catalysis through catalyst encapsulation. ANGEW, 64(5), e202419575. (www)

  @article{ , abstract = {We report a light-responsive tetrahedral metal–organic capsule that binds a perrhenate catalyst, which is released selectively upon irradiation with 350 nm light, turning on the catalytic reduction of organic carbonyls by hydrosilanes. The catalytic activity can be switched off by heating at 75 °C for 2.5 h, which stimulates capsule reformation and catalyst re-encapsulation. Multiple on-off cycles were shown, with a clear relationship between product yield and light irradiation time. Encapsulation thus enables the coupling of light-responsiveness to catalysis in a manner that might be generalized to other catalysts and capsules.}, archive = {J_ANGEW}, author = {Amit Ghosh and John D. Thoburn and Jonathan R. Nitschke}, doi = {10.1002/anie.202419575}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419575}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-responsive aldehyde-reduction catalysis through catalyst encapsulation}, volume = {64}, year = {2025}, }
• (2025). Enantioselective [3+2] annulation of aldimines with alkynes by scandium-catalyzed C−H activation. ANGEW, 64(5), e202419567. (www)

  @article{ , abstract = {The enantioselective [3+2] annulation of readily accessible aldimines with alkynes via C−H activation is, in principle, a straightforward and atom-efficient route for synthesizing chiral 1-aminoindenes, which are important components in a wide array of natural products, bioactive molecules, and functional materials. However, such asymmetric transformation has remained undeveloped to date due to the lack of suitable chiral catalysts. Here, we report for the first time the enantioselective [3+2] annulation of aldimines with alkynes via C−H activation using chiral half-sandwich scandium catalysts. This protocol enabled the synthesis of diverse multi-substituted chiral 1-aminoindene derivatives with 100 % atom-efficiency, broad substrate scope, and high regio- and enantioselectivity. Density functional theory (DFT) analyses have revealed that a noncovalent C−H⋅⋅⋅π interaction between a tert -Bu substituent in the chiral cyclopentadienyl (Cp) ligand and the phenyl ring of an aromatic aldimine substrate played an important role in achieving a high level of enantioselectivity. This work not only offers an efficient and selective route for synthesizing a new family of chiral 1-aminoindene derivatives but also offers unprecedented insights into enantioselectivity control in chiral Cp-ligated metal catalysts.}, archive = {J_ANGEW}, author = {Aniket Mishra and Jiameng Hu and Xuefeng Cong and Qingde Zhuo and Masayoshi Nishiura and Gen Luo and Zhaomin Hou}, doi = {10.1002/anie.202419567}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419567}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective [3+2] annulation of aldimines with alkynes by scandium-catalyzed C−H activation}, volume = {64}, year = {2025}, }
• (2025). Modification of ZIF-8 membranes for gas separation using X-ray radiation. ANGEW, 64(5), e202419532. (www)

  @article{ , abstract = {We report an X-ray radiation-induced modification of the structure and gas permeation behavior of ZIF-8 membranes. With 300 min irradiation time, CO 2 permeance decreases by only 9 %, while N 2 and CH 4 permeances reduce by 75 and 65 %, respectively, leading to 3.7- and 2.6-fold enhancements in ideal selectivity for CO 2 /N 2 and CO 2 /CH 4 .}, archive = {J_ANGEW}, author = {Dennis T. Lee and Mueed Ahmad and Peter Corkery and J. Anibal Boscoboinik and D. Howard Fairbrother and Michael Tsapatsis}, doi = {10.1002/anie.202419532}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419532}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modification of ZIF-8 membranes for gas separation using X-ray radiation}, volume = {64}, year = {2025}, }
• (2025). An isolable base-stabilized diazosilenyl cation. ANGEW, 64(5), e202419491. (www)

  @article{ , abstract = {In contrast to the emerging chemistry of stable diazoalkenes, there are not yet any studies devoted to heavier silicon analogues, diazosilenes. Here, we report the synthesis of a base-stabilized diazosilenyl cation 2 by the reaction of base-stabilized C -phosphonio-silyne 1 with N 2 O. This silicon analog of diazoalkenes 2 exhibits a remarkable stability thanks to the coordination of phosphine and phosphine oxide ligands at the cationic silicon center. In addition, DFT calculations predict that, due to a particular stabilizing effect of the electropositive silicon atom, for diazosilenes (R 2 Si=C=N 2 ), the presence of π-donor substituents is not essential to prevent N 2 dissociation, contrary to carbon analogues. Interestingly, diazosilenyl cation 2 tends to isomerize into (silylene)(phosphonio)diazomethane 7 via a 1,2-phosphine ligand migration and thus exhibits dual reactivity as a diazoalkene and as a diazo-substituted silylene.}, archive = {J_ANGEW}, author = {Shintaro Takahashi and Aurora Rodríguez-Álvarez and Antoine Baceiredo and Pierre Lavedan and Nathalie Saffon-Merceron and Vicenç Branchadell and Tsuyoshi Kato}, doi = {10.1002/anie.202419491}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419491}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An isolable base-stabilized diazosilenyl cation}, volume = {64}, year = {2025}, }
• (2025). Meta-dimethylation of arenes via catellani reaction from aryl thianthrenium salts. ANGEW, 64(5), e202419472. (www)

  @article{ , abstract = {Here we report the reaction of aryl thianthrenium salts that allows selective functionalization of the meta position of arenes. The combination of a site-selective thianthrenation with a Catellani reaction provides access to 3,5-dimethylated arenes. The developed reaction is complementary to the previously discovered reductive ipso -alkylation of aryl thianthrenium salts and extends the possibilities for late-stage methylation of arenes with a single aryl thianthrenium salt.}, archive = {J_ANGEW}, author = {Michał Mrozowicz and Sagnik Chatterjee and Markella Aliki Mermigki and Dimitrios A. Pantazis and Tobias Ritter}, doi = {10.1002/anie.202419472}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Meta-dimethylation of arenes via catellani reaction from aryl thianthrenium salts}, volume = {64}, year = {2025}, }
• (2025). Engineered nanobodies bind bismuth, indium and gallium for applications in theranostics. ANGEW, 64(5), e202419455. (www)

  @article{ , abstract = {Targeted theranostics heavily rely on metal isotopes conjugated to antibodies. Single-domain antibodies, known as nanobodies, are much smaller in size without compromising specificity and affinity. The conventional way of conjugating metals to nanobodies involves non-specific modification of amino acid residues with bifunctional chelating agents. We demonstrate that mutagenesis of a single residue in a nanobody creates a triple cysteine motif that selectively binds bismuth which is, for example, used in targeted alpha therapy. Two mutations create a quadruple cysteine mutant specific for gallium and indium used in positron emission tomography and single-photon emission computed tomography, respectively. Labelling is quantitative within a few minutes. The metal nanobodies maintain structural integrity and stability over weeks, resist competition from endogenous metal binders like glutathione, and retain functionality.}, archive = {J_ANGEW}, author = {Pritha Ghosh and Lani J. Davies and Christoph Nitsche}, doi = {10.1002/anie.202419455}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419455}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered nanobodies bind bismuth, indium and gallium for applications in theranostics}, volume = {64}, year = {2025}, }
• (2025). Dicyanocarbene-induced metal-free efficient quinoidization for the development of fused N-type organic semiconductors. ANGEW, 64(5), e202419318. (www)

  @article{ , abstract = {Dicyanomethylene-terminated quinoidal materials are promising n -type organic semiconductors featuring excellent electron mobilities and air stability. Traditional synthetic methods of these materials such as Takahashi reaction, require the use of expensive palladium catalyst and halogenated substrates. However, for electron-rich fused aromatic compounds, the poor stability after halogenation renders their halogenated derivatives unsuitable as reaction precursors. To address this issue, we present a new metal-free synthetic approach using 2-(dimethylsulfaneylidene)malononitrile as the quinoidization reagent, which is successfully applied to various electron-rich fused aromatic compounds, leading to the corresponding quinoidal compounds with high yields up to 94 %. We proposed the reaction mechanism, and investigated the physical properties of four fused quinoidal materials based on highly electron-rich fused aromatic compounds, which are scarce to be synthesized by the traditional method. Furthermore, these fused quinoidal materials were utilized in field-effect transistors, achieving high electron mobilities up to 1.33 cm 2 V −1 s −1 . We provide an effective synthetic approach to expand the library of high-performance n -type small-molecule semiconductors.}, archive = {J_ANGEW}, author = {Runshi Wu and Fei Huang and Renjie Xu and Wuyue Liu and Cheng Zhang and Xiaozhang Zhu}, doi = {10.1002/anie.202419318}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419318}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dicyanocarbene-induced metal-free efficient quinoidization for the development of fused N-type organic semiconductors}, volume = {64}, year = {2025}, }
• (2025). Promoting charge-carriers dynamics by relaxed lattice strain in A-site-doped halide perovskite for photocatalytic h2 evolution. ANGEW, 64(5), e202419082. (www)

  @article{ , abstract = {Because of the unique and superior optoelectronic properties, metal halide perovskites (MHPs) have attracted great interest in photocatalysis. Element doping strategy is adopted to modify perovskite materials to improve their photocatalytic performance. However, the contribution of bare doping-site onto photocatalytic efficiency, and the correlation between doping locations and activity have not yet to be demonstrated. The unique properties of non-active alkali metals promoted us to systematically explore the potential of A-site-doped MHPs for photocatalysis. Herein, we dope potassium (K + ) into CsPbBr 3 via an anti-solvent precipitation method and first reveal that the occupied locations of K + in CsPbBr 3 is lattice incorporation rather than surface segregation, which would change from A-site substitution to interstitial site in lattice with the increase of K + concentrations. Taking hydrogen (H 2 ) evolution as a model reaction, photocatalytic activity of CsPbBr 3 after K + doping could be significantly improved ~11-fold with A-site substitution, which is superior to that of interstitial site doping. Moreover, other alkali metals including lithium (Li), sodium (Na), and rubidium (Rb) doping give the same results. The structure of photocatalysts during reaction confirmed the contribution of A-site doping onto enhanced photocatalytic activity. Mechanistic insights show it is a result of the relaxed lattice strain induced promoted charge-carriers dynamics and upward shifting of band after K + A-site doping.}, archive = {J_ANGEW}, author = {Qing Guo and Jin-Dan Zhang and Jia-Mei Liu and Ya-Jing Chen and Bin Qin and Jing Xia and Li-Na Guo and Xin-Hua Duan and Li-Zhu Wu}, doi = {10.1002/anie.202419082}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419082}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting charge-carriers dynamics by relaxed lattice strain in A-site-doped halide perovskite for photocatalytic h2 evolution}, volume = {64}, year = {2025}, }
• (2025). Ultrahigh proton selectivity by assembled cationic covalent organic framework nanosheets. ANGEW, 64(5), e202419034. (www)

  @article{ , abstract = {Ionic covalent organic framework (COF) nanosheets are becoming increasingly attractive as promising two-dimensional (2D) materials for proton transport due to their ionic functionality and tailor-made pores. However, most synthetic methods for nanosheets rely on surface-assisted methods or phase transformation often yielding nanosheets with low aspect ratios. In this study, we present a bottom-up approach utilizing an oil-oil-water triphase system to achieve the large-scale synthesis of ionic COF nanosheets. The intermediate oil layer in this system modulates the diffusion rate of monomers from the top oil phase into the aqueous phase, enabling in-plane anisotropic secondary growth from the initial discrete fibrous structure into large and crystalline COF nanosheets. The ionic COF nanosheets exhibit excellent proton permeability while simultaneously excluding other cations by casting into crack-free membranes, demonstrating efficient HCl extraction from acidic water waste. This strategy for larger-scale COF nanosheet growth will offer an alternative platform for designing multifunctional COF membranes with applications in sophisticated separation technologies.}, archive = {J_ANGEW}, author = {Xin Liu and Weibin Lin and Khozama Bader Al Mohawes and Niveen M. Khashab}, doi = {10.1002/anie.202419034}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419034}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrahigh proton selectivity by assembled cationic covalent organic framework nanosheets}, volume = {64}, year = {2025}, }
• (2025). Genetic incorporation of a thioxanthone-containing amino acid for the design of artificial photoenzymes. ANGEW, 64(5), e202419022. (www)

  @article{ , abstract = {Genetically encodable photosensitizers allow the design of artificial photoenzymes to expand the scope of abiological reactions. Herein, we report the genetic incorporation of a thioxanthone-containing amino acid into a protein scaffold via an engineered pyrrolysyl-tRNA/pyrrolysyl-tRNA synthetase pair. The designer enzyme was engineered to catalyze a dearomative [2+2] cycloaddition reaction in high yields (up to>99 % yield) with excellent enantioselectivity (up to 98 : 2 e.r.). This work provides a robust and facile method for photoenzyme design and lays the foundation for the development of further photoenzymatic reactions.}, archive = {J_ANGEW}, author = {Kai-Yue Chen and Hui Ming and He-Xiang Wang and Hua-Qi Wang and Zheng Xiang}, doi = {10.1002/anie.202419022}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202419022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Genetic incorporation of a thioxanthone-containing amino acid for the design of artificial photoenzymes}, volume = {64}, year = {2025}, }
• (2025). Biofuel-driven stepping chiral supramolecular transfer container. ANGEW, 64(5), e202418938. (www)

  @article{ , abstract = {Herein, we reported a biofuel-driven recyclable chiral supramolecular transfer container based on hexacationic triphenylamine cage and nucleotides. Possessing rotatable paddle rigid backbones, the artificial receptor effectively encapsulated nucleotides with a high binding constant up to 5.37×10 5 M −1 in water, displaying guest-induced efficient fluorescence enhancement with quantum yield increased from 6.5 % to 16.6 %. Especially, the achiral cage could effectively bind with adenosine triphosphate to activate chirality transfer from substrates to the single molecular container, giving circularly polarized luminescence at 575 nm and positive Cotton effect peaks with significant asymmetric factor ( g abs =+6.4×10 −4 ). Meanwhile, the adaptive chiral supramolecule not only has reversible thermal responsiveness but also could stepwise regulate chirality transfer by the catalysis of hexokinase and apyrase in tandem, showing recovery adaptive chirality after refueled, achieving dynamically regulated programmable multistate chiral luminescent supramolecules. Therefore, the biofuel-driven chiral supramolecular transfer container could be successfully applied in chiral logic gates and multilevel information encryption, providing new insight into intelligent chiral materials.}, archive = {J_ANGEW}, author = {Jie Yu and Huijia Yu and Yugui Qiu and Heng-Yi Zhang and Xiufang Xu and Yu Liu}, doi = {10.1002/anie.202418938}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418938}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biofuel-driven stepping chiral supramolecular transfer container}, volume = {64}, year = {2025}, }
• (2025). A chemically powered rotary molecular motor based on reversible oxazepine formation. ANGEW, 64(5), e202418933. (www)

  @article{ , abstract = {While biological machines are powered mainly by chemical transformations, chemically driven artificial rotary motor systems are very limited. Here, we report an aniline-phenol-based rotary molecular motor that operates via an information ratchet mechanism. The 360° directional rotation about a single covalent bond can be chemically driven by reversible oxazepine formation. Both the oxazepine formation and hydrolysis steps are kinetically gated via dynamic kinetic resolution, arising from the kinetic bias of chiral catalysts for enantiomers. Given the 95 % ee (97.5 : 2.5) and 88 % ee (94 : 6) of the individual gating steps of motor analogues, the overall directionality ratio could be calculated to be 91.7 : 8.3 (97.5 %×94 %≈91.7 %), which means that the motor will make one mistake (backward rotation) approximately every 11 to 12 turns.}, archive = {J_ANGEW}, author = {Tian-Jiao Han and Xin-Yan Ke and Min-Can Wang and Shao-Fei Ni and Guang-Jian Mei}, doi = {10.1002/anie.202418933}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418933}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A chemically powered rotary molecular motor based on reversible oxazepine formation}, volume = {64}, year = {2025}, }
• (2025). Enantioselective three-component α-allylic alkylation of α-amino esters by synergistic photoinduced Pd/Carbonyl catalysis. ANGEW, 64(5), e202418910. (www)

  @article{ , abstract = {Photoinduced excited-state Pd catalysis has emerged as an intriguing strategy for unlocking new reactivity potential of simple substrates. However, the related transformations are still limited and the enantiocontrol remains challenging. Organocatalysis displays unique capability in substrate activation and stereocontrol. Combination of organocatalysis and photoinduced excited-state Pd catalysis may provide opportunities to develop new enantioselective reactions from simple substrates. By applying cooperative triple catalysis including excited-state Pd catalysis, ground-state Pd catalysis, and carbonyl catalysis, we have successfully realized enantioselective α-allylic alkylation of α-amino esters with simple styrene and alkyl halide starting materials. The reaction allows rapid modular assembly of the three reaction partners into a variety of chiral quaternary α-amino esters in good yields with 90–99 % ee, without protecting group manipulations at the active NH 2 group. The cooperation of the chiral pyridoxal catalyst and the chiral phosphine ligand accounts for the excellent chirality induction.}, archive = {J_ANGEW}, author = {Haohao Han and Wuqi Yi and Shaojie Ding and Xinyi Ren and Baoguo Zhao}, doi = {10.1002/anie.202418910}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418910}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective three-component α-allylic alkylation of α-amino esters by synergistic photoinduced Pd/Carbonyl catalysis}, volume = {64}, year = {2025}, }
• (2025). Highly oriented and ordered co-assembly monolayers for inverted perovskite solar cells. ANGEW, 64(5), e202418883. (www)

  @article{ , abstract = {Perovskite solar cells with inverted architecture have remarkable power conversion efficiency (PCE) and operating stability based on self-assembled molecules (SAMs) hole transport layer. Homogeneous distribution and covalent binding mode of SAM monolayers are critical to improving interfacial property and reducing interfacial losses, which can be achieved through molecular design and co-assembly strategy. Here, we propose co-assembly strategy with SAM by employing a novel 2D π-conjugated structure graphdiyne derivative (PAG) with phosphoric acid groups. Through the π-π interaction and hydrogen bonding between PAG and SAM, the enhanced tridentate anchoring and highly ordered molecular orientation perpendicular to the substrate are successfully achieved. The improvement of interfacial characteristics further optimizes the crystalline quality and buried interface properties of perovskite films, allowing us to achieve a remarkable PCE of 26.10 % under standard illumination.}, archive = {J_ANGEW}, author = {Yilin Chang and Le Liu and Lu Qi and Jiajia Du and Qinglin Du and Zhibin Yu and Zhiwei Ma and Tonggang Jiu and Yuliang Li}, doi = {10.1002/anie.202418883}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418883}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly oriented and ordered co-assembly monolayers for inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Modular access to c2’-Aryl/Alkenyl nucleosides with electrochemical stereoselective cross-coupling. ANGEW, 64(5), e202418806. (www)

  @article{ , abstract = {Chemically modified oligonucleotides have garnered significant attention in medicinal chemistry, chemical biology, and synthetic biology due to their enhanced stability in vivo compared to naturally occurring oligonucleotides. However, current methods for synthesizing modified nucleosides, particularly at the C2’-position, are limited in terms of efficiency, modularity, and selectivity. Herein, we report a new approach for the synthesis of highly functionalized C2’-α-aryl/alkenyl nucleosides via an electrochemical nickel-catalyzed cross-coupling of 2’-bromo nucleosides with a variety of (hetero)aryl and alkenyl iodides. This method affords a diverse array of C2’- α-aryl/alkenyl nucleosides with excellent stereoselectivity, broad substrate scope, and good functional group compatibility. We further synthesized oligonucleotides incorporating C2’-aryl-modified thymidine moieties and demonstrated that their annealed double-stranded DNAs exhibit decreased melting temperatures (Tm). Additionally, oligonucleotides with C2’-aryl modifications at the 3’ end showed enhanced resistance to 3’-exonuclease degradation and C2’-aryl modifications did not impede the cellular uptake process, highlighting the potential of these modified oligonucleotides for therapeutic applications.}, archive = {J_ANGEW}, author = {Jia-Bao Wang and Yu Shen and Qing-Long Yan and Wei-Jun Kong and Yong Nian and Ming Shang}, doi = {10.1002/anie.202418806}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418806}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular access to c2’-Aryl/Alkenyl nucleosides with electrochemical stereoselective cross-coupling}, volume = {64}, year = {2025}, }
• (2025). Formation of H2O2 in near-neutral zn-air batteries enables efficient oxygen evolution reaction. ANGEW, 64(5), e202418792. (www)

  @article{ , abstract = {Rechargeable Zn-air batteries (ZABs) with near-neutral electrolytes hold promise as cheap, safe and sustainable devices, but they suffer from slow charge kinetics and remain poorly studied. Here we reveal a charge storage mechanism of near-neutral Zn-air batteries that is mediated by formation of dissolved hydrogen peroxide upon cell discharge and its oxidation upon charge. This H 2 O 2 -mediated pathway facilitates oxygen evolution reaction (OER) at ~1.5 V vs. Zn 2+ /Zn, reducing charge overpotentials by ~0.2–0.5 V and mitigating carbon corrosion—a common issue in ZABs. The manifestation of this mechanism strongly depends on the electrolyte composition and positive electrode material, contributing up to ~60 % of the capacity with ZnSO 4 solutions and carbon nanotubes. Enhancing the H 2 O 2 -mediated pathway offers a route to higher energy efficiency and durability in near-neutral ZABs, advancing practical, sustainable energy storage.}, archive = {J_ANGEW}, author = {Roman R. Kapaev and Nicole Leifer and Alagar Raja Kottaichamy and Amit Ohayon and Langyuan Wu and Menny Shalom and Malachi Noked}, doi = {10.1002/anie.202418792}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418792}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formation of H2O2 in near-neutral zn-air batteries enables efficient oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed C(sp3)−H α-acetylation: Generation of quaternary centers. ANGEW, 64(5), e202418692. (www)

  @article{ , abstract = {α-substituted ketones are important chemical targets as synthetic intermediates as well as functionalities in natural products and pharmaceuticals. We report the α-acetylation of C(sp 3 )−H substrates R−H with arylmethyl ketones ArC(O)Me to provide α-alkylated ketones ArC(O)CH 2 R at RT with t BuOO t Bu as oxidant via copper(I) -diketiminato catalysts. Proceeding via alkyl radicals R•, this method enables α-substitution with bulky substituents without competing elimination that occurs in more traditional alkylation reactions between enolates and alkyl electrophiles. DFT studies suggest the intermediacy of copper(II) enolates [Cu II ](CH 2 C(O)Ar) that capture alkyl radicals R• to give R−CH 2 C(O)Ar outcompeting dimerization of the copper(II) enolate to give the 1,4-diketone ArC(O)CH 2 CH 2 C(O)Ar.}, archive = {J_ANGEW}, author = {Otome E. Okoromoba and Ting-An Chen and Eun Sil Jang and Claire L. McMullin and Thomas R. Cundari and Timothy H. Warren}, doi = {10.1002/anie.202418692}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418692}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed C(sp3)−H α-acetylation: Generation of quaternary centers}, volume = {64}, year = {2025}, }
• (2025). Independent LUMO reactivity in mesoionic N-heterocyclic thiones: Synthesis of a stable radical anion. ANGEW, 64(5), e202418673. (www)

  @article{ , abstract = {Mesoionic compounds, with positive and negative charges, are expected to have dual-site highest occupied molecular orbital (HOMO, donor) and lowest unoccupied molecular orbital (LUMO, acceptor) reactivity. Herein, we report a novel class of air-stable mesoionic N -heterocyclic thiones (mNHTs) synthesized from abnormal N -heterocyclic carbenes (aNHCs). DFT studies revealed a highly polarized exocyclic thione moiety and computed Fukui function analysis suggests the dual-site HOMO/LUMO reactivity of mNHTs predicting donor property at the negatively charged ‘S’ center while acceptor property at the cationic imidazole ring. The independent LUMO reactivity of the mNHT was realized by its chemical reduction to an elusive radical anion, which was characterized by a single crystal X-raydiffraction study. Further, we explore the reactivity of radical anion for the activation of SO 2 gas, C−Br bonds of aryl bromide and photocatalytic functionalization of C−X (X = F, Br) bonds. This work unlocks the independent LUMO reactivity of a mesoionic compound.}, archive = {J_ANGEW}, author = {Subir Maji and Biplab Gope and Madhur Sharma and Arpan Das and Anex Jose and Amit Biswas and Kalishankar Bhattacharyya and Swadhin K. Mandal}, doi = {10.1002/anie.202418673}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418673}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Independent LUMO reactivity in mesoionic N-heterocyclic thiones: Synthesis of a stable radical anion}, volume = {64}, year = {2025}, }
• (2025). Propeller-shaped blatter-based triradicals: Distortion-free triangular spin system and spin-state-dependent photophysical properties. ANGEW, 64(5), e202418655. (www)

  @article{ , abstract = {Herein, we report the synthesis and properties of triptycene-based C 3v - and C s -symmetric stable triradicals. SQUID magnetometry showed the propeller-shaped triradicals were both an antiferromagnetic equilateral triangle spin system with small spin-spin interactions J / k B ~−120 K and −106 K, leading to ca. 4/6 coexistence of the doublet/quartet states in thermal equilibrium at room temperature. The triradicals exhibited characteristic NIR absorption bands reaching 1000 nm, which was solely ascribed to the triradical in the doublet state by variable-temperature spectroscopic studies and quantum chemical calculations. Taking advantage of the spin-specific absorption feature, we found that the triradicals in the low-spin state undergo symmetry-breaking charge transfer, while those in the high-spin state fall into a monoradical-like excited state.}, archive = {J_ANGEW}, author = {Takero Aoki and Hikaru Sotome and Daiki Shimizu and Hiroshi Miyasaka and Kenji Matsuda}, doi = {10.1002/anie.202418655}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418655}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Propeller-shaped blatter-based triradicals: Distortion-free triangular spin system and spin-state-dependent photophysical properties}, volume = {64}, year = {2025}, }
• (2025). Microfluidic precision manufacture of high performance liquid chromatographic microspheres. ANGEW, 64(5), e202418642. (www)

  @article{ , abstract = {A key bottleneck in developing chromatographic material is the chemically entangled control of morphology, pore structure, and material chemistry, which holds back precision material manufacture in order to pursue advanced separation performance. In this work, a precision manufacture strategy based on droplet microfluidics was developed, for production of highly efficient chromatographic microspheres with independent control over particle morphology, pore structure and material chemistry. The droplet-synthesized microspheres display extremely narrow particle size distribution (CV<3 %), enabling a 100 % production yield due to complete elimination of sieving steps. More importantly, the size of the droplet-synthesized microspheres is freely adjustable without the need for re-optimizing chemical recipes or reaction conditions. The resulting materials exhibit excellent separation efficiencies, achieving a reduced plate height of h min =1.67. This precision manufacture strategy also allows for flexible pore design and continuous pore size adjustment across three orders of magnitudes, providing a novel vehicle for resolution fine-tuning targeting protein separation. Besides traditional silica, organic–inorganic hybrid silica, zirconia, and titania microspheres can also be precisely synthesized on the same platform, supporting various separation applications and operating conditions. Powered by precision manufacture, super-throughput production, and versatile chemistry, the high-performance droplet-synthesized separation material will pave the way towards green and precision chromatographic industry.}, archive = {J_ANGEW}, author = {Kaiyue Sun and Juxing Zeng and Ya Liu and Zhuoheng Zhou and Jikai Chen and Jiawei Chen and Xiangyu Huang and Fan Gao and Xin Wang and Xin Zhang and Xiaofei Wang and Sebastiaan Eeltink and Bo Zhang}, doi = {10.1002/anie.202418642}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418642}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Microfluidic precision manufacture of high performance liquid chromatographic microspheres}, volume = {64}, year = {2025}, }
• (2025). Non-canonical c16 homoterpene biosynthesis widespread in actinobacteria. ANGEW, 64(5), e202418613. (www)

  @article{ , abstract = {A novel biosynthetic pathway towards the rare and underexplored non-canonical family of homoterpenes was discovered in actinobacteria through targeted genome mining and enzymatic in vitro reconstitution. The pathway comprises initial methylation-induced double bond isomerization of farnesyl diphosphate (FPP) to (2 E ,7 E )-6-methyl-farnesyl diphosphate, catalyzed by a novel family of methyltransferases with unique dual function. The resulting linear C 16 double bond isomer of FPP constitutes the specific substrate for a distinct family of type I terpene cyclases, catalyzing diverse cyclization reactions. Functional characterization of nine enzyme pairs led to discovery of five unprecedented homoterpene natural products. The enzymological novelty enables the development of novel biocatalytic and genetically programmable synthetic strategies towards methylated terpenoids with potentially unique properties (“magic methyl effect”).}, archive = {J_ANGEW}, author = {Tatjana Reuter and Lars Dieminger and Sarah Steidle and Katrin Zoller and Maximilian Holocher and Lin Zhou and Dominik Matthias Hanauska and Katharina Racz and Lena Barra}, doi = {10.1002/anie.202418613}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418613}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-canonical c16 homoterpene biosynthesis widespread in actinobacteria}, volume = {64}, year = {2025}, }
• (2025). Stabilisation of a strontium hydride with a monodentate carbazolyl ligand and its reactivity. ANGEW, 64(5), e202418558. (www)

  @article{ , abstract = {The molecular strontium hydride 2 [( dtbp Cbz)SrH(L)] 2 (L=benzene, toluene) was isolated and stabilized by employing a sterically demanding carbazole ligand ( dtbp Cbz=1,8-bis(3,5-ditertbutylphenyl)-3,6-ditertbutylcarbazolyl). Compound 2 was synthesized via phenylsilane metathesis with the corresponding amide ( dtbp Cbz)SrN(SiMe 3 ) 2 and characterized by 1 H NMR, XRD and vibrational spectroscopy methods. We further investigated the stoichiometric reactivity of 2 towards carbon monoxide, azobenzene and trimethylsilylacetylene, showing three distinct reactivity pathways: addition, reduction and deprotonation. The reaction of 2 with carbon monoxide yields the ethenediolate complex 4 via addition, while with azobenzene reduction of the N−N double bond and release of hydrogen were observed, affording a heteroleptic strontium complex with a radical azobenzenyl ligand ( 5 ). The terminal alkyne is deprotonated by the hydride moiety to give the acetylide complex 6 .}, archive = {J_ANGEW}, author = {Lucas Winkler and Alexander Hinz}, doi = {10.1002/anie.202418558}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418558}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilisation of a strontium hydride with a monodentate carbazolyl ligand and its reactivity}, volume = {64}, year = {2025}, }
• (2025). Highly strained, fully π-conjugated porphyrin cyclophanes: Template-free synthesis and global aromaticity. ANGEW, 64(5), e202418532. (www)

  @article{ , abstract = {Porphyrin-based nanohoops, nanorings, and cages with fully π-conjugated structures are highly sought after, but their synthesis remains challenging. Herein, we report the template-free synthesis of a highly strained, bithiophene-bridged porphyrin cyclophane ( 1 ) from a porphyrin quinone via a stereoselective nucleophilic addition followed by intermolecular Yamamoto coupling strategy. X-ray crystallographic analyses of 1 and its dication 1 2+ reveal significantly distorted cyclophane-like geometries, with calculated strain energies of 51.2 and 80.7 kcal/mol, respectively. While the neutral compound 1 exhibits localized aromaticity, the dication 1 2+ is globally aromatic, with the porphyrin unit displaying weak antiaromaticity. Additionally, the dication 1 2+ undergoes nucleophilic addition with chloride, relieving strain. This work presents a novel synthetic strategy for highly strained, fully π-conjugated systems with intriguing electronic properties and chemical reactivity.}, archive = {J_ANGEW}, author = {Longbin Ren and Yi Han and Liuying Jiao and Ya Zou and Jishan Wu}, doi = {10.1002/anie.202418532}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418532}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly strained, fully π-conjugated porphyrin cyclophanes: Template-free synthesis and global aromaticity}, volume = {64}, year = {2025}, }
• (2025). Organic crystal with anti-stokes photoluminescent excitation and thermally activated delayed fluorescence features. ANGEW, 64(5), e202418516. (www)

  @article{ , abstract = {Thermal activation process utilizes environmental thermal energy to help supplement energy for the nonspontaneous energy-consuming upconversion physical transitions with positive free energy change (Δ G >0). Reverse intersystem crossing (rISC) and hot band absorption are two kinds of thermal activation transitions. Thermally activated delayed fluorescence (TADF) materials with rISC have significantly propelled advancements in organic semiconductors. Hot band absorption, enables anti-Stokes photoluminescence, offering a promising route for efficient photon upconversion. In this work, we constructed a crystal consisting of a donor-acceptor type TADF molecule, DPQ-DPAC, demonstrating dual thermal activation properties of hot band absorption with a notable 0.1 eV anti-Stokes shift emission and proficient TADF performance. Only in the crystal TADF efficiency facilitates and the photoluminescence quantum yield elevates to an impressive 90.8 %. Combining the extended absorption spectrum, these enhancements collectively realize anti-Stokes photoluminescence in crystal. Experimental and theoretical results on the DPQ-DPAC crystal indicate optimizations in its conformational and vibrational modes, resulting in enhancements to its properties. This finding provides insight into crafting organic materials with thermally activated functionalities and contributes to fully exploiting the potential of organic materials, further advancing versatile materials applications.}, archive = {J_ANGEW}, author = {Jiaxuan Wang and Heming Zhang and Baoyan Liang and Zhengqian Tu and Lianbao Ke and Zhiqiang Li and Hai Bi and Yue Wang}, doi = {10.1002/anie.202418516}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic crystal with anti-stokes photoluminescent excitation and thermally activated delayed fluorescence features}, volume = {64}, year = {2025}, }
• (2025). Determining the absolute configuration of small molecules by diffusion NMR experiments. ANGEW, 64(5), e202418508. (www)

  @article{ , abstract = {Enantiomers are ubiquitous in many areas of science, such as pharmaceuticals, agriculture, and food. Nuclear magnetic resonance (NMR) alone is not able to differentiate enantiomers as their spectra are identical. However, these can be distinguished using chiral auxiliaries (such as chiral complexing agents) that form diastereomeric complexes, but absolute identification is still troublesome, usually requiring a chemical reaction with a chiral derivatizing agent. Here, we propose a new method that uses a hybrid mixture of solvating agents in a simple comparison of diffusion NMR experiments, which can discriminate enantiomers in both frequency and diffusion domains, dubbed CHIMERA (CHIral Micelle Enantiomer Resolving Agent). The new method was assessed for twenty-three small chiral molecules using a combination of BINOL and (−)-DMEB, a chiral surfactant, and initial results indicate that absolute configuration can be obtained from a simple experiment.}, archive = {J_ANGEW}, author = {Tadeu Luiz Gomes Cabral and Guilherme Dal Poggetto and João Pedro Brussolo da Silva and Mathias Nilsson and Claudio F. Tormena}, doi = {10.1002/anie.202418508}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418508}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Determining the absolute configuration of small molecules by diffusion NMR experiments}, volume = {64}, year = {2025}, }
• (2025). Porous molecular crystals derived from cofacial Porphyrin/Phthalocyanine heterodimers. ANGEW, 64(5), e202418443. (www)

  @article{ , abstract = {Porphyrin-based porous materials are of growing interest as heterogeneous catalysts especially for reactions that are of importance to sustainability. Here we demonstrate that porous molecular crystals can be prepared by the simple co-crystallisation of tetraphenylporphyrin (TPP) with octa(2’,6’-di- iso -propylphenoxy)phthalocyanine or some of its metal complexes [(dipPhO) 8 PcM; M=H 2 , Al−OH, Ti=O, Mn−Cl, Fe−Cl, Co, Ni, Cu, Zn, Ga−Cl, Ag, In−Cl or Au−Cl]. This process is facilitated by the efficient formation of the supramolecular heterodimer between TPP and (dipPhO) 8 PcM, which is driven by the complementary shape and symmetry of the two macrocycles. The (dipPhO) 8 PcM component directs the crystal structure of the heterodimers to form Phthalocyanine Nanoporous Crystals (PNCs) of similar structure to those formed by (dipPhO) 8 PcM alone. The incorporation of TPP appears to partially stabilise the PNCs towards the removal of included solvent and for cocrystals containing (dipPhO) 8 PcCo stability can be enhanced further by the insitu addition of 4,4-bipyridyl to act as a “molecular wall tie”. These stabilised PNC/TPP cocrystals have a Brunauer–Emmett–Teller surface area ( SA BET ) of 454 m 2 g −1 and a micropore volume ( V mp ) of 0.22 mL g −1 . The reactivity of both macrocycles within the PNC/TPP co-crystals is demonstrated by insitu metal insertion.}, archive = {J_ANGEW}, author = {Nikolaos-Angelos Stamos and Shannah Kerrigan and Alexander Stiven and Gary S. Nichol and C. Grazia Bezzu and Luke Burt and Stephen A. Moggach and Gemma F. Turner and Neil B. McKeown}, doi = {10.1002/anie.202418443}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418443}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Porous molecular crystals derived from cofacial Porphyrin/Phthalocyanine heterodimers}, volume = {64}, year = {2025}, }
• (2025). Photooxidation of polyolefins to produce materials with in-chain ketones and improved materials properties. ANGEW, 64(5), e202418411. (www)

  @article{ , abstract = {Herein, we report a selective photooxidation of commodity postconsumer polyolefins to produce polymers with in-chain ketones. The reaction does not involve the use of catalyst, metals, or expensive oxidants, and selectively introduces ketone functional groups. Under mild and operationally simple conditions, yields up to 1.23 mol % of in-chain ketones were achieved. Installation of in-chain ketones resulted in materials with improved adhesion of the materials and miscibility of mixed plastics relative to the unfunctionalized plastics. The introduction of ketone groups into the polymer backbone allows these materials to react with diamines, forming dynamic covalent polyolefin networks. This strategy allows for the upcycling of mixed plastic waste into reprocessable materials with enhanced performance properties compared to polyolefin blends. Mechanistic studies support the involvement of photoexcited nitroaromatics in consecutive hydrogen and oxygen atom transfer reactions.}, archive = {J_ANGEW}, author = {Xin Liu and Zhitao Hu and Brandon S. Portela and Emma M. Rettner and Agustin Pineda and Joel Miscall and Nicholas A. Rorrer and Amber T. Krummel and Robert S. Paton and Garret M. Miyake}, doi = {10.1002/anie.202418411}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418411}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photooxidation of polyolefins to produce materials with in-chain ketones and improved materials properties}, volume = {64}, year = {2025}, }
• (2025). Activation and C−C coupling of aryl iodides via bismuth photocatalysis. ANGEW, 64(5), e202418367. (www)

  @article{ , abstract = {Within the emerging field of bismuth redox catalysis, the catalytic formation of C−C bonds using aryl halides would be highly desirable; yet such a process remains a synthetic challenge. Herein, we present a chemoselective bismuth-photocatalyzed activation and subsequent coupling of (hetero)aryl iodides with pyrrole derivatives to access C(sp 2 )−C(sp 2 ) linkages through C−H functionalization. This unique reactivity is the result of the bismuth complex featuring two redox state-dependent interactions with light, which 1) activates the Bi(I) complex for oxidative addition via MLCT, and 2) promotes the homolytic cleavage of aryl Bi(III) intermediates through a LLCT process.}, archive = {J_ANGEW}, author = {Mauro Mato and Alexios Stamoulis and Paolo Cleto Bruzzese and Josep Cornella}, doi = {10.1002/anie.202418367}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418367}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activation and C−C coupling of aryl iodides via bismuth photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Biosynthetic origin of the methoxy group in quinine and related alkaloids. ANGEW, 64(5), e202418306. (www)

  @article{ , abstract = {Quinine is a historically important natural product containing a methoxy group that has been assumed to be incorporated at a late pathway stage. Here we show that the methoxy group in quinine and related alkaloids is introduced onto the starting substrate tryptamine. Feeding studies definitively show that 5-methoxytryptamine is utilized as a quinine biosynthetic intermediate in planta . We discover the biosynthetic genes that encode the responsible oxidase and methyltransferase, and we use these genes to reconstitute the early steps of the alkaloid biosynthetic pathway in Nicotiana benthamiana to produce a mixture of methoxylated and non-methoxylated alkaloid intermediates. Importantly, we show that the co-occurrence of both tryptamine and 5-methoxytryptamine substrates, along with the substrate promiscuity of downstream pathway enzymes, enable parallel formation of both methoxylated and non-methoxylated alkaloids.}, archive = {J_ANGEW}, author = {Blaise Kimbadi Lombe and Tingan Zhou and Lorenzo Caputi and Kerstin Ploss and Sarah E. O'Connor}, doi = {10.1002/anie.202418306}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418306}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biosynthetic origin of the methoxy group in quinine and related alkaloids}, volume = {64}, year = {2025}, }
• (2025). Anomeric amide-enabled alkene-arene and alkene-alkene aminative coupling. ANGEW, 64(5), e202418141. (www)

  @article{ , abstract = {Despite the prominence of C−N bond forming cross-coupling reactions as a strategy to assemble molecular fragments, aminative coupling approaches, in which two fragments are assembled directly at the heteroatom, represents a rarely exploited retrosynthetic strategy. Herein, we report the design, synthesis, and implementation of an anomeric amide reagent capable of promoting highly regioselective aminative alkene-arene and alkene-alkene coupling reactions. This transformation follows a sequence of catalyst-free chloroamination, N-deprotection, and formal nitrene functionalization, all in one-pot. Due to the simplicity of both the protocol and the building blocks required, high-throughput experimentation (HTE) was employed, in combination with a full-scale scope, to rapidly and efficiently explore a wide range of chemical space and determine the limits of reactivity. In addition, alternative reactivity modes from the functionalized intermediates delivered by this protocol demonstrate the divergent nature of this aminative coupling strategy.}, archive = {J_ANGEW}, author = {Colin Stein and Jasper L. Tyler and Julius Wiener and Florian Boser and Constantin G. Daniliuc and Frank Glorius}, doi = {10.1002/anie.202418141}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anomeric amide-enabled alkene-arene and alkene-alkene aminative coupling}, volume = {64}, year = {2025}, }
• (2025). Revisiting the baddeley reaction: Access to functionalized decalins by charge-promoted alkane functionalization. ANGEW, 64(5), e202418067. (www)

  @article{ , abstract = {C−H functionalization of purely aliphatic substrates is a challenging endeavor, as the absence of directing groups generally thwarts attempts at regiocontrol. This is particularly true for difunctionalization reactions, where the control of relative stereochemistry poses an additional obstacle. The Baddeley reaction of decalins, despite suffering from strong limitations with regard to yield and generality, stands as one of only few known transformations capable of regio- and stereocontrol in aliphatic C−H functionalization. Herein, we report a regio- and diastereoselective method for the double functionalization of decalins enabling access to a novel, unreported regioisomer in synthetically useful yields. This method was also successfully applied to a range of other alkane substrates, enabling a straightforward synthesis of keto alcohols from the simplest alkane building blocks.}, archive = {J_ANGEW}, author = {Miloš Vavrík and Phillip S. Grant and Daniel Kaiser and Tim Gruene and Nuno Maulide}, doi = {10.1002/anie.202418067}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418067}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revisiting the baddeley reaction: Access to functionalized decalins by charge-promoted alkane functionalization}, volume = {64}, year = {2025}, }
• (2025). How to easily depolymerize polyurethane foam wastes by superbase catalysts in ionic liquids below 100 °C. ANGEW, 64(5), e202418034. (www)

  @article{ , abstract = {This study introduces a novel and sustainable approach using Ionic Liquids (ILs) as a non-innocent solvent that enhances the performance of the basic catalysts to depolymerize polyurethane foam wastes (PUFWs) through hydrolysis, alcoholysis or aminolysis under mild conditions. The system is stable, fully recoverable, and reusable. Hydrolysis of PUFWs can occur in just 2 minutes at 95–98 °C, producing a white polyol that is easily separated and reused in new polyurethane synthesis. The method was successfully scaled up to depolymerize 200 g of PUFW per batch (1 kg overall depolymerization system). This scalability, combined with the medium‘s reusability without loss of effectiveness, highlights its strong potential for industrial applications.}, archive = {J_ANGEW}, author = {Rocio Villa and Rebeca Salas and María Maciá and Francisco Velasco and Belén Altava and Eduardo García-Verdugo and Pedro Lozano}, doi = {10.1002/anie.202418034}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202418034}, shortjournal = {Angew. Chem. Int. Edit.}, title = {How to easily depolymerize polyurethane foam wastes by superbase catalysts in ionic liquids below 100 °C}, volume = {64}, year = {2025}, }
• (2025). Doping Copper(I) in ag7 cluster for circularly polarized OLEDs with external quantum efficiency of 26.7 %. ANGEW, 64(5), e202417934. (www)

  @article{ , abstract = {Hetero-metal doping or substitution to create alloy clusters is a highly appealing strategy for improving physicochemical characteristics as well as tailoring optical and electronic properties, although high-yield synthesis of alloy clusters with precise positioning of doped metals is a daunting challenge. Herein, we manifest rational synthesis of chiral alloy cluster enantiomers R / S -Ag 6 Cu in 85 %–87 % yield by replacing one Ag(I) atom with Cu(I) in homometallic clusters R / S -Ag 7 , achieving circularly polarized luminescence (CPL) with a quantum yield beyond 90 %. As a small energy gap (ca. 0.07 eV) between S 1 and T 1 states facilitates thermally activated delay fluorescence (TADF) through reverse intersystem crossing (RISC), the photoluminescence (PL) of R / S -Ag 7 and R / S -Ag 6 Cu at ambient temperature originates mostly from TADF (85 % and 86 %) in place of phosphorescence (15 % and 14 %). Relative to those of R / S -Ag 7 , copper(I) doping not only triples PL quantum yields of R / S -Ag 6 Cu due to accelerating ISC (intersystem crossing) and RISC, but also doubles CPL asymmetry factors of R / S -Ag 6 Cu ascribed to rigidizing cluster structure through stronger Ag−Cu interaction apart from dramatically improving thermodynamic stability. Solution-processable circularly polarized organic light-emitting diodes (CP-OLEDs) demonstrate high-efficiency circularly polarized electroluminescence (CPEL) with external quantum efficiency (EQE) of 26.7 %, which is superior to most of red-emitting OLEDs through solution process.}, archive = {J_ANGEW}, author = {Xu-Yang Ding and Lin-Xi Shi and Jin-Yun Wang and Liang-Jin Xu and Li-Yi Zhang and Zhong-Ning Chen}, doi = {10.1002/anie.202417934}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417934}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Doping Copper(I) in ag7 cluster for circularly polarized OLEDs with external quantum efficiency of 26.7 %}, volume = {64}, year = {2025}, }
• (2025). Ligand-protected golden fullerene au42 with unprecedented metal coordination number of 15. ANGEW, 64(5), e202417904. (www)

  @article{ , abstract = {A golden fullerene with a composition of [Au 42 (Ph 3 P) 10 (5-CF 3 -Hpa) 8 ] (CF 3 COO) 2 (5-CF 3 -H 2 pa=5-trifluoropyridyl-2-amine) ( Au 42 ) has been synthesized with pyridylamino and phosphine ligands as the protecting agents. Single crystal X-ray structural analysis reveals that the cluster has a D 3 h Au 42 10+ core, which can be depicted as a centered core–shell structure Au@Au 15 @Au 26 . The 41 Au atoms of the Au 15 @Au 26 core–shell can be derived from placing a gold atom in the center of each polygon of C 78 ( D 3 h ). Surprisingly, the centered gold atom of this noble cluster has the highest coordination number in metal nanoclusters of 15. Quantum-chemical studies suggest that the excellent stability of Au 42 results from both the superatomic characteristics of the Au 42 kernel and the gold-ligand interactions.}, archive = {J_ANGEW}, author = {Heng-Wang Luyang and Cong-Qiao Xu and Shang-Fu Yuan and Jun Li and Quan-Ming Wang}, doi = {10.1002/anie.202417904}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417904}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-protected golden fullerene au42 with unprecedented metal coordination number of 15}, volume = {64}, year = {2025}, }
• (2025). Characterization of iminobismuthanes and catalytic reduction of organic azides via Bi(I)/Bi(III) redox cycling. ANGEW, 64(5), e202417864. (www)

  @article{ , abstract = {We report the stoichiometric and catalytic reactivity of organobismuth(I) complexes with organic azides. Treatment of N,C,N -pincer bismuthinidenes with organic azides (acyl, sulfonyl, and bulky aryl) results in monomeric iminobismuthanes which can be structurally characterized —including the formal Bi=N double bond— by multinuclear NMR spectroscopy and single-crystal X-ray diffraction. Building upon the stoichiometric reactivity of the monomeric iminobismuthanes, catalytic reduction of a broad range of organic azides is developed. DFT calculations of the catalytic reaction pathway support the redox nature of the overall process.}, archive = {J_ANGEW}, author = {Hye Won Moon and Nils Nöthling and Markus Leutzsch and Jennifer Kuziola and Josep Cornella}, doi = {10.1002/anie.202417864}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Characterization of iminobismuthanes and catalytic reduction of organic azides via Bi(I)/Bi(III) redox cycling}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed difluoroalkylation of β,γ-unsaturated α-amino nitrile derived lithium reagents. ANGEW, 64(5), e202417858. (www)

  @article{ , abstract = {Organolithium reagents, known for their low cost, ready availability, and high reactivity, allow fast cross-coupling under ambient conditions. However, their direct cross-coupling with fluoroalkyl electrophiles remains a formidable challenge due to the easy formation of thermo-unstable fluoroalkyl lithium species during the reaction, which are prone to decomposition via rapid α/β-fluoride elimination. Here, we exploit heteroatom-stabilized allylic anions to harness the exceptional reactivity of organolithium reagents, enabling the compatibility of difluoroalkyl halides and facilitating versatile and precise fluorine functionality introduction under mild conditions. In this process, a nickel-catalyzed difluoroalkylation of β,γ-unsaturated α-amino nitrile derived lithium reagents ( N -stabilized allyl lithium reagents) with various difluoroalkyl bromides has been developed, opening a new avenue to access fluorinated compounds through catalytic cross-coupling of organolithium reagents with fluoroalkyl electrophiles. This approach allows for the efficient and precise construction of secondary C(sp 3 )−CF 2 R bonds, previously challenging in transition-metal-catalyzed fluoroalkylation reactions due to β-hydride elimination. The rapid fluorine-editing of drugs demonstrates the synthetic versatility and utility of this protocol, showing the perspective in modern drug discovery.}, archive = {J_ANGEW}, author = {Fei-Fei Tong and Yun-Cheng Luo and Hai-Yang Zhao and Xia-Ping Fu and Xingang Zhang}, doi = {10.1002/anie.202417858}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417858}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed difluoroalkylation of β,γ-unsaturated α-amino nitrile derived lithium reagents}, volume = {64}, year = {2025}, }
• (2025). [5]Helicene based π-conjugated macrocycles with persistent figure-eight and möbius shapes: Efficient synthesis, chiral resolution and bright circularly polarized luminescence. ANGEW, 64(5), e202417749. (www)

  @article{ , abstract = {π-Conjugated chiral shape-persistent molecular nanocarbons hold great potential as chiroptical materials, though their synthesis remains a considerable challenge. Here, we present a simple approach using Suzuki coupling of a [5]helicene building block with various aromatic units, enabling the one-pot synthesis of a series of chiral macrocycles with persistent figure-eight and Möbius shapes. Single-crystal structures of 7 compounds were solved, and 22 enantiomers were separated by preparative chiral HPLC. A notable pyrene-bridged figure-eight macrocycle, with its rigid, fully π-conjugated and overcrowded structure, exhibited pure excimer emission and outstanding circularly polarized luminescence (CPL) properties, including a large dissymmetric factor (| g lum |=3.8×10 −2 ) and significant CPL brightness ( B CPL =710.5 M −1 cm −1 ). This method provides a versatile synthetic platform for producing various chiral D 2 -symmetric figure-eight macrocycles and singly or triply twisted Möbius macrocycles with C 2 and D 3 symmetry, offering tunable chiroptical properties for CPL applications.}, archive = {J_ANGEW}, author = {Qifeng Zhou and Wei Yuan and Yunfei Li and Yi Han and Lintao Bao and Wei Fan and Liuying Jiao and Yanli Zhao and Yong Ni and Ya Zou and Hai-Bo Yang and Jishan Wu}, doi = {10.1002/anie.202417749}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {[5]Helicene based π-conjugated macrocycles with persistent figure-eight and möbius shapes: Efficient synthesis, chiral resolution and bright circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). A carbazole-centered expanded helicene stabilized with hexabenzocoronene (HBC) units. ANGEW, 64(5), e202417745. (www)

  @article{ , abstract = {The synthesis and stabilization of heteroatom-doped nanocarbon molecules, such as carbazole-containing (super)helicenes, present significant challenges due to the complexities involved in maintaining structural integrity and electronic functionality. In this study, we successfully synthesized a carbazole-centered expanded tris-hexabenzo[7]helicene ( 1 ) via a facile FeCl 3 -mediated Scholl coupling reaction. 1 exhibits both chemical and chiral stability and demonstrates fluorescence at 628 nm with a quantum yield of 0.40. Additionally, the enantiomers of 1 display pronounced chiroptical properties, including a distinct circular dichroism (CD) signal spanning from 300 to 600 nm. The absorption dissymmetry factor (| g abs |) is determined to be 2.98×10 −3 , while the circularly polarized luminescence brightness ( B CPL ) is measured as 32.50 M −1 cm −1 .}, archive = {J_ANGEW}, author = {Xin-Yue Wang and Jinku Bai and Yun-Jia Shen and Zhi-Ao Li and Han-Yuan Gong}, doi = {10.1002/anie.202417745}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417745}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A carbazole-centered expanded helicene stabilized with hexabenzocoronene (HBC) units}, volume = {64}, year = {2025}, }
• (2025). Homologation of alkenyl carbonyls via a Cyclopropanation/Light-mediated selective C−C cleavage strategy. ANGEW, 64(5), e202417719. (www)

  @article{ , abstract = {We report herein our studies on the direct photoactivation of carbonyl cyclopropanes to give biradical intermediates, leading to selective cleavage of the more substituted carbon-carbon bond. Depending on the substrate structure, extended alkenes were isolated or directly reacted in a photo-Nazarov process to give bicyclic products. Based on these results, a unified reductive ring-opening reaction was developed by using diphenyl disulfide as a hydrogen atom transfer (HAT) reagent. By performing a sequential cyclopropanation/selective ring opening reaction, we achieved a CH 2 insertion into the α,β bond of both acyclic and cyclic unsaturated carbonyl compounds. Our protocol provides a further tool for the modification of the carbon framework of organic compounds, complementing the recent progress in “skeletal editing”.}, archive = {J_ANGEW}, author = {Tin V. T. Nguyen and Duncan K. Brownsey and André Bossonnet and Matthew D. Wodrich and Jerome Waser}, doi = {10.1002/anie.202417719}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417719}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Homologation of alkenyl carbonyls via a Cyclopropanation/Light-mediated selective C−C cleavage strategy}, volume = {64}, year = {2025}, }
• (2025). Construction of slide-ring polymers based on Pillar[5]Arene/Alkyl chain Host−Guest interactions. ANGEW, 64(5), e202417713. (www)

  @article{ , abstract = {Slide-ring polymers exhibit distinctive mechanical properties, making them highly promising for applications in emerging fields such as energy storage devices and smart sensing. However, existing slide-ring polymer systems primarily rely on hydrophilic-hydrophobic interactions to achieve ring-axle interlocking in aqueous phases. This reliance limits the construction of slide-ring networks mainly to water-soluble polymers, excluding a diverse range of lipophilic polymers. Therefore, it is crucial to introduce efficient construction strategies that facilitate interpenetration in organic solvents, enabling the development of diverse slide-ring polymers and expanding their range and applications. Herein, by utilizing the pillar[5]arene/alkyl chain host−guest interactions, we successfully facilitated the interpenetration of a pillar[5]arene and poly(caprolactone), enabling the efficient construction of two slide-ring polymer networks in organic solvents. One of these two slide-ring polymers demonstrates a unique network deformation mechanism along with outstanding mechanical properties compared with the control covalently cross-linked polymer network, including maximum stress (4.43 vs 1.98 MPa), maximum strain (1285 vs 330 %), and toughness (35.4 vs 3.92 MJ/m 3 ). More importantly, this strategy of making slide-ring polymers is highly versatile, given the wide range of macrocyclic arenes and alkyl chain-containing polymers it can accommodate.}, archive = {J_ANGEW}, author = {Liya Chen and Yang Liu and Wei You and Jiao Wang and Zejian He and Honggang Mei and Xue Yang and Wei Yu and Guangfeng Li and Feihe Huang}, doi = {10.1002/anie.202417713}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417713}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of slide-ring polymers based on Pillar[5]Arene/Alkyl chain Host−Guest interactions}, volume = {64}, year = {2025}, }
• (2025). Regulation of exciton effects in functionalized conjugated polymers by B-N lewis pairs for visible-light photocatalysis. ANGEW, 64(5), e202417712. (www)

  @article{ , abstract = {Strong excitonic effects are common in organic conjugated polymer semiconductors, severely hindering the generation of free charge carriers for conducting photocatalysis. Therefore, exploring new channels to modulate exciton dissociation in polymers is far-reaching in facilitating photocatalysis. A series of B−N Lewis pair functionalized conjugated polymers have been developed to minimize exciton effects by modulating charge transfer pathways. Theoretical studies have shown that introducing B−N Lewis pairs can dramatically increase the distance of charge transfer ( D index) and the amount of electron transfer and reduce the Coulomb attraction energy ( E C ), which contributes to breaking the equilibrium of the coexistence of excitons and charge carriers. Further experimental results show that the singlet excitons are efficiently dissociated into more free-charge carriers under photoexcitation to participate in surface reactions. The optimized polymer PyPBM shows an exponential increase in photocatalytic hydrogen and hydrogen peroxide production performance by visible light illumination.}, archive = {J_ANGEW}, author = {Chenglong Ru and Xiaoyu Nie and Zhi-An Lan and Zhiming Pan and Wandong Xing and Sibo Wang and Jimmy C. Yu and Yidong Hou and Xinchen Wang}, doi = {10.1002/anie.202417712}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417712}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulation of exciton effects in functionalized conjugated polymers by B-N lewis pairs for visible-light photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Visible-light-driven oxidation of benzene to phenol with o2 over photoinduced oxygen-vacancy-rich WO3. ANGEW, 64(5), e202417703. (www)

  @article{ , abstract = {Direct photocatalytic conversion of benzene to phenol with molecular oxygen (O 2 ) is a green alternative to the traditional synthesis. The key is to find an effective photocatalyst to do the trick. Defect engineering of semiconductors with oxygen vacancies (OVs) is an emerging strategy for catalyst fabrication. OVs can trap electrons to promote charge separation and serving as adsorption sites for O 2 activation. However, the randomly distribution of OVs on the semiconductor surface often results in mismatching the charge carrier dynamics under irradiation, thus failing to fulfill the unique advantages of OVs for photoredox functions. Herein, we demonstrate that abundant OVs can be facilely generated and precisely located adjacent to the reductive sites on reducible oxide semiconductors such as tungsten oxide (WO 3 ) via a simple photochemistry strategy. Such photoinduced OVs are well suited for photocatalytic benzene oxidation with O 2 as they readily capture photogenerated electrons from the reductive sites of WO 3 to activate adsorbed O 2 . The oxygen-isotope-labeling experiments further confirm that the OVs also facilitate the integration of oxygen atoms from O 2 into phenol, revealing in detail the pathway for photocatalytic benzene hydroxylation. This study demonstrates that the photochemistry approach is an appealing strategy for the synthesis of high-performance OVs-rich photocatalysts for solar-induced chemical conversion.}, archive = {J_ANGEW}, author = {Wenhui Zhou and Xiaoyi Wang and Feng Lin and Sikang Xue and Wei Lin and Yidong Hou and Zhiyang Yu and Masakazu Anpo and Jimmy C. Yu and Jinshui Zhang and Xinchen Wang}, doi = {10.1002/anie.202417703}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417703}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-light-driven oxidation of benzene to phenol with o2 over photoinduced oxygen-vacancy-rich WO3}, volume = {64}, year = {2025}, }
• (2025). Leveraging ligand desymmetrization to enrich structural diversity of zirconium Metal–Organic frameworks for toxic chemical adsorption. ANGEW, 64(5), e202417664. (www)

  @article{ , abstract = {The discovery of metal–organic frameworks (MOFs) with novel structures provides significant opportunities for developing porous solids with new properties and enriching the structural diversity of functional materials for various applications. The rational design of building units with specific geometric conformations is essential to direct the construction of MOFs with unique properties. Herein, we leverage a ligand desymmetrization approach to construct a series of new MOFs. A flexible tetratopic carboxylate ligand with a tetrahedral geometry was designed and assembled with a Zr 6 cluster, generating four Zr-based MOF structures: NU-2600, NU-2700, NU-2800, and NU-1802, in which the ligand configurations and Zr 6 cluster connectivities can be controlled by varying solvents and modulators during synthesis. Except for NU-1802, these represent entirely new topologies. Notably, NU-1802 exhibits structural flexibility, with up to a 74 % reduction in the unit cell volume as confirmed by single-crystal X-ray diffraction studies. Given their microporous structures, we studied the adsorption behaviors of n -hexane and 2-chloroethyl ethyl sulfide to explore the structure–property relationships of these MOFs. Overall, this work highlights ligand desymmetrization as a powerful method to enrich MOF structural diversity and access complex MOFs with non-default topologies suitable for applications such as toxic gas capture.}, archive = {J_ANGEW}, author = {Yongwei Chen and Haomiao Xie and Xingjie Wang and Fanrui Sha and Kent O. Kirlikovali and Xiaoliang Wang and Zi-Ming Ye and Xianhui Tang and Chenghui Zhang and Gregory W. Peterson and Zhibo Li and Omar K. Farha}, doi = {10.1002/anie.202417664}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Leveraging ligand desymmetrization to enrich structural diversity of zirconium Metal–Organic frameworks for toxic chemical adsorption}, volume = {64}, year = {2025}, }
• (2025). Two-dimensional Silver–Isocyanide frameworks. ANGEW, 64(5), e202417658. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) have been widely studied due to their versatile applications and easily tunable structures. However, heteroatom-metal coordination dominates the MOFs community, and the rational synthesis of carbon–metal coordination-based MOFs remains a significant challenge. Herein, two-dimensional (2D) MOFs based on silver–carbon linkages are synthesized through the coordination between silver(I) salt and isocyanide-based monomers at ambient condition. The as-synthesized 2D MOFs possess well-defined crystalline structures and a staggered AB stacking mode. Most interestingly, these 2D MOFs, without π–π stacking between layers, exhibit narrow band gaps down to 1.42 eV. As electrochemical catalysts for converting CO 2 to CO, such 2D MOFs demonstrate Faradaic efficiency over 92 %. Surprisingly, the CO 2 reduction catalyzed by these MOFs indicates favorable adsorption of CO 2 and *COOH on the active carbon sites of the isocyanide groups rather than on silver sites. This is attributed to the critical σ donor role of isocyanides and the corresponding ligand-to-metal charge–transfer effect. This work not only paves the way toward a new family of MOFs based on metal–isocyanide coordination but also offers a rare platform for understanding the electrocatalysis processes on strongly polarized carbon species.}, archive = {J_ANGEW}, author = {Kaiyue Jiang and Pu Yan and Pengfei Shi and Jichao Zhang and Xinyu Chai and Yunfei Wang and Chenhui Zhu and Chongqing Yang and Chenbao Lu and Yi Liu and Kecheng Cao and Xiaodong Zhuang}, doi = {10.1002/anie.202417658}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-dimensional Silver–Isocyanide frameworks}, volume = {64}, year = {2025}, }
• (2025). Photoelectrochemical ethylene glycol oxidization coupled with hydrogen generation using metal oxide photoelectrodes. ANGEW, 64(5), e202417648. (www)

  @article{ , abstract = {Photoelectrochemical (PEC) water splitting represents a promising approach for harnessing solar energy and transforming it into storable hydrogen. However, the complicated 4-electron transfer process of water oxidation reaction imposes kinetic limitations on the overall efficiency. Herein, we proposed a strategy by substituting water oxidation with the oxidation of ethylene glycol (EG), which is a hydrolysis byproduct of polyethylene terephthalate (PET) plastic waste. To achieve this, we developed and synthesized BiVO 4 /NiCo-LDH photoanodes capable of achieving a high Faradaic efficiency (FE) exceeding 85 % for the oxidation of EG to formate in a strongly alkaline environment. The reaction mechanism was further elucidated using in situ FTIR spectroscopy. Additionally, we successfully constructed an unassisted PEC device for EG oxidation and hydrogen generation by pairing the translucent Mo : BiVO 4 /NiCo-LDH photoanode with a state-of-the-art Cu 2 O photocathode, resulting in an approximate photocurrent density of 2.3 mA/cm 2 . Our research not only offers a PEC pathway for converting PET plastics into valuable chemicals but also enables simultaneous hydrogen production.}, archive = {J_ANGEW}, author = {Fusong Kang and Qingjie Wang and Dongfeng Du and Linxiao Wu and Daniel Wun Fung Cheung and Jingshan Luo}, doi = {10.1002/anie.202417648}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417648}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoelectrochemical ethylene glycol oxidization coupled with hydrogen generation using metal oxide photoelectrodes}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of ryanodane diterpenoids garajonone and 3-epi-garajonone. ANGEW, 64(5), e202417647. (www)

  @article{ , abstract = {Ryanodane diterpenes are structurally complex natural products that are well-known for their high degree of oxidation and the challenges associated with synthesizing them within the terpene class. Herein, we present a two-stage synthetic strategy that draws inspiration from the broad biosynthesis of terpenes, allowing us to achieve the first chemical synthesis of garajonone, a ryanodane diterpenoid that occurs naturally at low abundance, as well as its epimer, 3- epi -garajonone. The key to this success lies in the rapid construction of the carbon framework of the target molecule by employing an early-stage palladium-catalyzed Heck/carbonylative esterification cascade annulation, followed by successive late-stage selective redox manipulation to establish the desired oxidation state of the molecule. This research not only showcases the synthesis of garajonone and its epimer but also provides a platform for the chemical synthesis of other members and analogs of this complex diterpenoid family.}, archive = {J_ANGEW}, author = {Jin-Bao Qiao and Long Meng and Jia-Yi Pei and Hui Shao and Yu-Ming Zhao}, doi = {10.1002/anie.202417647}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417647}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of ryanodane diterpenoids garajonone and 3-epi-garajonone}, volume = {64}, year = {2025}, }
• (2025). Upcycling polyethylene to high-purity hydrogen under ambient conditions via mechanocatalysis. ANGEW, 64(5), e202417644. (www)

  @article{ , abstract = {Polyethylene (PE) is the most abundant plastic waste, and its conversion to hydrogen (H 2 ) offers a promising route for clean energy generation. However, PE decomposition typically requires high temperatures due to its strong chemical bonds, leading to significant carbon emissions and low H 2 selectivity (theoretically less than 75 vol % after accounting for further steam-reforming reactions). Here, we report a mechanocatalytic strategy that upcycles PE into high-purity H 2 (99.4 vol %) with an exceptional H 2 recovery ratio of 98.5 % (versus 15.7 % via thermocatalysis), using manganese as a catalyst at a low temperature of 45 °C. This method achieves a reaction rate 3 orders of magnitude higher than thermocatalysis. The marked improvement in H 2 recovery ratio is mainly due to metal carbides formation induced by the mechanocatalytic process, which does not catalyze hydrocarbons formation. This work is expected to advance studies of the conversion of polyolefins to high-purity H 2 with net-zero carbon emissions.}, archive = {J_ANGEW}, author = {Ruiqian Gu and Tonghui Wang and Yue Ma and Tong-Xing Wang and Rui-Qi Yao and Yingnan Zhao and Zi Wen and Gao-Feng Han and Xing-You Lang and Qing Jiang}, doi = {10.1002/anie.202417644}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Upcycling polyethylene to high-purity hydrogen under ambient conditions via mechanocatalysis}, volume = {64}, year = {2025}, }
• (2025). Integrated omnidirectional design of non-volatile solid additive enables binary organic solar cells with efficiency exceeding 19.5 %. ANGEW, 64(5), e202417643. (www)

  @article{ , abstract = {Solid additives have drawn great attention due to their numerous appealing benefits in enhancing the power conversion efficiencies (PCEs) of organic solar cells (OSCs). To date, various strategies have been reported for the selection or design of non-volatile solid additives. However, the lack of a general design/evaluation principles for developing non-volatile solid additives often results in individual solid additives offering only one or two efficiency-boosting attributes. In this work, we propose an integrated omnidirectional strategy for designing non-volatile solid additives. By validating the method on the 4,5,9,10-pyrene diimide (PyDI) system, a novel non-volatile solid additive named PyMC5 was designed. PyMC5 is capable of enhancing device performance by establishing synergistic dual charge transfer channels, forming appropriate interactions with active layer materials, reducing non-radiative voltage loss and optimizing film morphology. Notably, the binary device (PM6 : L8-BO) treated by PyMC5 achieved a PCE over 19.5 %, ranking among the highest reported to date. In addition, the integration of PyMC5 mitigated the degradation process of the devices under photo- and thermal-stress conditions. This work demonstrates an efficient integrated omnidirectional approach for designing non-volatile solid additives, offering a promising avenue for further advancements in OSC development.}, archive = {J_ANGEW}, author = {Ya-Ting Wang and Wen-Jing Sun and Yamin Zhang and Bo-Yang Zhang and Yun-Tao Ding and Ze-Qi Zhang and Lingxian Meng and Kexin Huang and Wei Ma and Hao-Li Zhang}, doi = {10.1002/anie.202417643}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417643}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated omnidirectional design of non-volatile solid additive enables binary organic solar cells with efficiency exceeding 19.5 %}, volume = {64}, year = {2025}, }
• (2025). Asymmetric carbene insertion into Se−S bonds by synergistic Rh(II)/Guanidine catalysis involving chalcogen-bond assistance. ANGEW, 64(5), e202417636. (www)

  @article{ , abstract = {The efficient construction of chalcogen-atom-based chiral compounds remains a challenge, despite the importance of organoselenium and organosulfur compounds in life and materials science. Chalcogen atoms can form net attractive interactions called chalcogen bonds, but it is an undeveloped tool to assist asymmetric catalysis. Herein, we report an enantioselective insertion platform to install a stereogenic center bearing selenyl and thiocyano functional groups. Our method operates by synergistic catalysis by a chiral guanidine and an achiral dirhodium complex in a three-component or four-component reaction, through Se−S bond insertion into carbene species, competing successfully with the spontaneous racemic process and showing high regioselectivity. As elucidated by spectroscopic experiments and computational studies, a unique mechanism involving chalcogen as well as hydrogen bonding was established to account for the enantiocontrol. The high stereoselectivity holds for a broad array of selenylthiocyanatopropanoates, which showed excellent anti-inflammatory toward IL-1β and low cytotoxicity.}, archive = {J_ANGEW}, author = {Xin He and Yihua Fu and Ruiying Xi and Cefei Zhang and Kexin Lan and Zhishan Su and Fei Wang and Xiaoming Feng and Xiaohua Liu}, doi = {10.1002/anie.202417636}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417636}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric carbene insertion into Se−S bonds by synergistic Rh(II)/Guanidine catalysis involving chalcogen-bond assistance}, volume = {64}, year = {2025}, }
• (2025). Reversible hydrogen Acceptor–Donor enables relay mechanism for nitrate-to-ammonia electrocatalysis. ANGEW, 64(5), e202417631. (www)

  @article{ , abstract = {Electrocatalytic nitrate reduction is a crucial process for sustainable ammonia production. However, to maximize ammonia yield efficiency, this technology inevitably operates at the potentials more negative than 0 V vs. RHE, leading to high energy consumption and competitive hydrogen evolution. To eradicate this issue, hydrogen tungsten bronze (H x WO 3 ) as reversible hydrogen donor-acceptor is partnered with copper (Cu) to enable a relay mechanism at potentials positive than 0 V vs. RHE, which involves rapid intercalation of H into H x WO 3 lattice, prompt de-intercalation of the lattice H and transfer onto Cu, and spontaneous H-mediated nitrate-to-ammonia conversion on Cu. The resulting catalysts demonstrated a high ammonia yield rate of 3332.9±34.1 mmol g cat −1 h −1 and a Faraday efficiency of ~100 % at 0.10 V vs. RHE, displaying a record-low estimated energy consumption of 17.6 kWh kg ammonia −1 . Using these catalysts, we achieve continuous ammonia production in an enlarged flow cell at a real energy consumption of 17.0 kWh kg ammonia −1 .}, archive = {J_ANGEW}, author = {Yuefei Li and Ye Liu and Mingkai Zhang and Linsen Li and Zhao Jiang and Bingying Han and Baojun Wang and Jiayuan Li}, doi = {10.1002/anie.202417631}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417631}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversible hydrogen Acceptor–Donor enables relay mechanism for nitrate-to-ammonia electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Building ultrastrong, tough and biodegradable thermoplastic elastomers from multiblock copolyesters via a “Reserve-release” crystallization strategy. ANGEW, 64(5), e202417627. (www)

  @article{ , abstract = {Simultaneously attaining high strength and toughness has been a significant challenge in designing thermoplastic elastomers, especially biodegradable ones. In this context, we present a class of biodegradable elastomers based on multiblock copolyesters that afford extraordinary strength, toughness, and low-strain resilience despite expedient chemical synthesis and sample processing. With the incorporation of the semi-crystalline soft block and the judicious selection of block periodicity, the thermoplastic materials feature low quiescent crystallinity (“reserve”) albeit with vast potential for strain-induced crystallization (“release”), resulting in their significantly enhanced ultimate strength and energy-dissipating capabilities. Moreover, a breadth of mechanical responses of the materials – from reinforced elastomers to shape-memory materials to toughened thermoplastics – can be achieved by orthogonal variation of segment lengths and ratios. This work and the “reserve-release” crystallization strategy herein highlight the double crystalline multiblock chain architecture as a potential avenue towards reconciling the strength-toughness trade-off in thermoplastic elastomers and can possibly be extended to other biodegradable building blocks to deliver functional materials with diverse mechanical performances.}, archive = {J_ANGEW}, author = {Xiangyu Miao and Rui Han and Juan Tian and Yuanchi Ma and Alejandro J. Müller and Zhibo Li}, doi = {10.1002/anie.202417627}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Building ultrastrong, tough and biodegradable thermoplastic elastomers from multiblock copolyesters via a “Reserve-release” crystallization strategy}, volume = {64}, year = {2025}, }
• (2025). Site-specific quadruple-functionalised antibodies. ANGEW, 64(5), e202417620. (www)

  @article{ , abstract = {Antibody–drug conjugates (ADCs) are a growing class of chemotherapeutic agents that have yielded striking clinical successes. However, the efficacy of ADCs often suffers from issues associated with tumor heterogeneity and resistance. To overcome these problems, a new generation of ADCs comprising a single monoclonal antibody with multiple different payloads attached, termed multi-payload ADCs, have been developed. Here we deploy multiple orthogonal site-specific protein modification strategies to generate highly homogeneous multi-functionalised antibody conjugates comprising up to four different functionalities installed at four unique sites on the antibody. This work, which includes the use of a site-specific cyclopropenone (CPO)-based reagent, represents the first example of a homogeneous multi-payload ADC with a payload count greater than two, and thereby facilitates the development of the next generation of ADCs.}, archive = {J_ANGEW}, author = {Toby Journeaux and Michael B. Geeson and Thomas V. Murray and Monika A. Papworth and Matt Gothard and Jason G. Kettle and Aldrin V. Vasco and Gonçalo J. L. Bernardes}, doi = {10.1002/anie.202417620}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417620}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-specific quadruple-functionalised antibodies}, volume = {64}, year = {2025}, }
• (2025). Elucidating confinement and microenvironment of ru clusters stably confined in MFI zeolite for efficient propane oxidation. ANGEW, 64(5), e202417618. (www)

  @article{ , abstract = {Achieving active and stable heterogeneous catalysts by encapsulating noble metal species within zeolites is highly promising for high utilization and cost efficiency in thermal and environmental catalytic reactions. Ru, considered an economical noble metal alternative with comparable performance, faces great challenges within MFI-type microporous zeolites due to its high cohesive energy and mobility. Herein, an innovative strategy was explored that couples hydrothermal in situ ligand protection with stepwise calcination in a flowing atmosphere to embed ultrasmall Ru clusters anchored at K + -healed silanol sites (≡Si−Ru δ+ −O−K complexes) within 10-membered ring sinusoidal channels of MFI. Comprehensive experiments and theoretical calculations unveiled that the interplay between confined Ru clusters and MFI induces local strain in MFI, creating a unique catalytic microenvironment around the Ru clusters. This synergy interaction enhances alkane deep oxidation as the confined Ru clusters and the MFI microenvironment collectively pre-activate C 3 H 8 and O 2 , facilitate the cleavage of C−H and C−C bonds at low temperatures. Notably, the stable geometric and electronic properties of the confined Ru show exceptional thermal stability up to 1000 °C, rivaling fresh catalysts. These findings shed vital methodological and mechanistic insights for developing efficacious heterogeneous catalysts for thermal catalysis.}, archive = {J_ANGEW}, author = {Jingjing Wang and Zeyu Jiang and Hengyue Xu and Xinzhe Li and Yanfei Jian and Lianghui Xia and Pei Su and Qiyuan Liu and Shouning Chai and Mudi Ma and Abdallah Amedlous and Mathias Barreau and Zhengping Hao and Jiaguo Yu and Chi He}, doi = {10.1002/anie.202417618}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Elucidating confinement and microenvironment of ru clusters stably confined in MFI zeolite for efficient propane oxidation}, volume = {64}, year = {2025}, }
• (2025). Photoexcitation-enhanced high-ionic conductivity in polymer electrolytes for flexible, all-solid-state lithium-metal batteries operating at room temperature. ANGEW, 64(5), e202417605. (www)

  @article{ , abstract = {Designing solid polymer electrolytes (SPEs) with high ionic conductivity for room-temperature operation is essential for advancing flexible all-solid-state energy storage devices. Innovative strategies are urgently required to develop SPEs that are safe, stable, and high-performing. In this work, we introduce photoexcitation-modulated heterojunctions as catalytically active fillers within SPEs, guided by photocatalytic design principles, and meanwhile employ natural bacterial cellulose to improve the compatibility with poly(ethylene oxide), improve the coordination environment of lithium salts, and optimize both ion transport and mechanical properties. In situ photothermal experiments and theoretical calculations reveal that the strong photogenerated electric field produced by trace heterojunctions within poly(ethylene oxide) electrolytes under photoexcitation significantly enhances lithium salt dissociation, increasing the concentration of mobile Li + . This results in a substantial increase in ionic conductivity, reaching 0.135 mS cm −1 at 25 °C, with a Li + transference number as high as 0.46. The flexible all-solid-state lithium-metal pouch cells exhibit an impressive discharge capacity of 178.8 mAh g −1 even after repeated bending and folding, and demonstrate exceptional long-term cycling stability, retaining 86.7 % of their initial capacity after 250 cycles at 1 C (25 °C). This research offers a novel approach to developing high-performance flexible lithium-metal batteries.}, archive = {J_ANGEW}, author = {Rong-Hao Wang and Weiyi Wang and Yu-Zhen Zhang and Wei Hu and Liang Yue and Jia-Hao Ni and Wan-Qun Zhang and Gang Pei and Shangfeng Yang and Li-Feng Chen}, doi = {10.1002/anie.202417605}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417605}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoexcitation-enhanced high-ionic conductivity in polymer electrolytes for flexible, all-solid-state lithium-metal batteries operating at room temperature}, volume = {64}, year = {2025}, }
• (2025). Single atomic cu-c3 sites catalyzed interfacial chemistry in Bi@C for ultra-stable and ultrafast sodium-ion batteries. ANGEW, 64(5), e202417602. (www)

  @article{ , abstract = {Regulating interfacial chemistry at electrode-electrolyte interface by designing catalytic electrode material is crucial and challenging for optimizing battery performance. Herein, a novel single atom Cu regulated Bi@C with Cu−C 3 site (Bi@SA Cu−C) have been designed via the simple pyrolysis of metal-organic framework. Experimental investigations and theoretical calculations indicate the Cu−C 3 sites accelerate the dissociation of P−F and C−O bonds in NaPF 6 -ether-based electrolyte and catalyze the formation of inorganic-rich and powerful solid electrolyte interphase. In addition, the Cu−C 3 sites with delocalized electron around Cu trigger an uneven charge distribution and induce an in-plane local electric field, which facilitates the adsorption of Na + and reduces the Na + migration energy barrier. Consequently, the obtained Bi@SA Cu−C achieves a state-of-the-art reversible capacity, ultrahigh rate capability, and long-term cycling durability. The as-constructed full cell delivers a high capacity of 351 mAh g −1 corresponding to an energy density of 265 Wh kg −1 . This work provides a new strategy to realize high-efficient sodium ion storage for alloy-based anode through constructing single-atom modulator integrated catalysis and promotion effect into one entity.}, archive = {J_ANGEW}, author = {Guochang Li and Yifan Tang and Yuhui Wang and Shuangxing Cui and Hao Chen and Yaoping Hu and Huan Pang and Lei Han}, doi = {10.1002/anie.202417602}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417602}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single atomic cu-c3 sites catalyzed interfacial chemistry in Bi@C for ultra-stable and ultrafast sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Promoting WLED-excited high temperature long afterglow by orthogonally anchoring chromophores into 0D metal-organic cages. ANGEW, 64(5), e202417593. (www)

  @article{ , abstract = {Afterglow materials have garnered significant interest due to distinct photophysical characteristics. However, it is still difficult to achieve long afterglow phosphorescence from organic molecules due to aggregation-caused quenching (ACQ) and energy dissipation. In addition, most materials reported so far have long afterglow emission only at room or even low temperatures, and mainly use UV light as an excitation source. In this work, we report a strategy to achieve high temperature long afterglow emission through the assembly of isolated 0D metal-organic cages (MOCs). In which, both ACQ and phosphorescence quenching effects are effectively mitigated by altering the stacking mode of organic chromophores through orthogonally anchoring into the edges of cubic MOCs. Furthermore, improvement in molecular rigidity, promotion of spin-orbit coupling and broadening of the absorption range are achieved through the MOC-engineering strategy. As a result, we successfully synthesized MOCs that can produce afterglow emission even after excitation by WLEDs at high temperatures (380 K). Moreover, the MOCs are capable of generating afterglow emissions when excited by mobile phone flashlight at room temperature. Given these features, the potential applications of MOCs in the visual identification of explosives, information encryption and multicolor display are explored.}, archive = {J_ANGEW}, author = {Zhong-Hao Wang and Chen-Hui Liu and Lin Zheng and Hui-Li Sun and Shao-Qi Guan and Zhong-Min Cao and Mei Pan and Cheng-Yong Su}, doi = {10.1002/anie.202417593}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting WLED-excited high temperature long afterglow by orthogonally anchoring chromophores into 0D metal-organic cages}, volume = {64}, year = {2025}, }
• (2025). A metal chelation therapy to effectively eliminate breast cancer and intratumor bacteria while suppressing tumor metastasis by copper depletion and zinc ions surge. ANGEW, 64(5), e202417592. (www)

  @article{ , abstract = {The intratumor microbiota results in the immunosuppressive microenvironment and facilitates tumor growth and metastasis. However, developing a synergistic therapy with antitumor, antibacterial, and antimetastatic effects faces enormous challenges. Here, we propose an innovative metal chelation therapy to effectively eliminate tumor and intratumor bacteria and suppress tumor metastasis. Different from traditional chelation therapy that only consumes metal elements, this therapy not only eliminates the crucial metal elements for tumor metabolism but also releases new metal ions with antitumor and antibacterial properties. Based on the high demand for copper in breast cancer, we prepare a fibrous therapeutic nanoagent (Zn-PEN) by chelating the copper chelator D-Penicillamine (D-PEN) with Zn 2+ . Firstly, Zn-PEN achieves dual inhibition of oxidative phosphorylation (OXPHOS) and glycolysis metabolism in breast cancer through copper depletion and Zn 2+ activated cGAS-STING pathway, thus inducing tumor cell death. Secondly, Zn-PEN has the capability to eradicate Fusobacterium nucleatum ( F. nucleatum ) in breast cancer, thereby mitigating its immunosuppressive impact on the tumor microenvironment. Finally, Zn-PEN effectively inhibits tumor metastasis through multiple routes, including the inhibition of epithelial-mesenchymal transition (EMT) process, activation of cGAS-STING pathway, and elimination with F. nucleatum . Therefore, we verify the feasibility of Zn-PEN mediated metal chelation therapy in a 4T1 model infected with F. nucleatum , providing a new therapeutic strategy for inhibiting tumor metastasis.}, archive = {J_ANGEW}, author = {Yulin Xie and Junrong Wang and Lei Li and Man Wang and Jikai Sun and Jiaying Chang and Jun Lin and Chunxia Li}, doi = {10.1002/anie.202417592}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417592}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A metal chelation therapy to effectively eliminate breast cancer and intratumor bacteria while suppressing tumor metastasis by copper depletion and zinc ions surge}, volume = {64}, year = {2025}, }
• (2025). Polymeric carbon nitride edged with spatially isolated donor and acceptor for sunlight-driven H2O2 synthesis and in-situ utilization. ANGEW, 64(5), e202417591. (www)

  @article{ , abstract = {On-site H 2 O 2 activation attracts much attention in energy conversion and environment remediation et al., yet remains challenging in its highly efficient and sustainable synthesis. Herein, we grafted a pair of spatially isolated donor (methoxyphenyl unit) and acceptor (anthraquinone unit) in polymeric carbon nitride edges, which induce directional electron-hole transfer to the two spatially separated dual active centers. Specifically, photogenerated electrons in the anthraquinone unit facilitate the 2e − ORR, while the methoxyphenyl unit, which gathers photogenerated holes, enables rapid 4e − WOR. More impressively, the anthraquinone unit also exhibits strong proton extraction capabilities to boost the generation of *OOH intermediates and H 2 O 2 . Consequently, the synthesized donor-polymeric carbon nitride-acceptor (DPA) catalyst shows a remarkable H 2 O 2 yield of 6497.1 μ M h −1 g −1 in pure water, surpassing traditional DP and PA catalysts. Because of its high efficiency, the H 2 O 2 product can efficiently degrade and mineralize various organic contaminants in a continuous-flow self-Fenton reactor under sunlight irradiation. Our work presents an unprecedented approach to designing photocatalysts with efficient H 2 O 2 synthesis and practical application from a molecular engineering perspective.}, archive = {J_ANGEW}, author = {Qiang Zhang and Kaiye Gu and Chaoran Dong and Chao Xue and Huinan Che and Kan Zhang and Yanhui Ao}, doi = {10.1002/anie.202417591}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417591}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polymeric carbon nitride edged with spatially isolated donor and acceptor for sunlight-driven H2O2 synthesis and in-situ utilization}, volume = {64}, year = {2025}, }
• (2025). Sustaining 500,000 folding cycles through bioinspired stress dispersion design in sodium-ion batteries. ANGEW, 64(5), e202417589. (www)

  @article{ , abstract = {Developing super-foldable electronic materials and devices presents a significant challenge, as intrinsic conductive materials are unable to achieve numerous true-folding operations (super-foldable) due to limitations from short-range forces of chemical bonds. Consequently, super-foldable batteries remain unexplored. This work focused on sodium-ion batteries as a breakthrough point to advance super-foldable devices. By employing a “2+1” bioinspired strategy, we stepwise designed and assembled super-foldable components, from substrates to electrodes, and to ultimately device. This bioinspired approach completely disperses folding stress and thus prevents the breakage of chemical bonds, enabling the successful fabrication of the first super-foldable ion battery. This battery can withstand true-folding at any angle, in any direction, and for an unprecedented number of cycles—far outperforming current foldable phones with hinge structures. Remarkably, after 500,000 true-folding cycles, the battery's microstructure remains intact with no significant degradation of electrochemical performance. Real-time dynamic folding observations reveal an M-shaped folding structure within the bioinspired materials, which effectively disperses stress via bulged layers, dispersed arcs, and slidable microgrooves that work together across different directions and dimensions to achieve super-foldability. Mechanical simulations vividly verify this principle. This work represents a breakthrough in super-foldable devices, offering valuable insights and promoting practical application for future super-foldable devices.}, archive = {J_ANGEW}, author = {Shu Pu and Guangtao Zan and Hongmin Zhou and Kangze Dong and Xiaoge Mao and Qingsheng Wu and Tong Wu}, doi = {10.1002/anie.202417589}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sustaining 500,000 folding cycles through bioinspired stress dispersion design in sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Exploiting high order magnetic anisotropy for advanced magnetocaloric refrigerants. ANGEW, 64(5), e202417582. (www)

  @article{ , abstract = {Three new 3 d – 4 f complexes of general formula trans -[MF 2 (py) 4 ][LnDOTA] (M=Cr 3+ or Co 3+ , Ln=Dy 3+ or Y 3+ , py=pyridine and DOTA=tetraazacyclododecane-N,N′,N′′,N′′′-tetraacetate) have been synthetised. The fluoride-bridged systems were designed to achieve perfect tetragonal symmetry by combining four-fold symmetric lanthanide and transition metal building blocks. From single crystal measurements, an unprecedented switch of the tetragonal anisotropy of the Dy 3+ complexes has been observed. A combination of spectroscopic observations, magnetometry measurements and ab initio calculations allowed us to pinpoint the origin of this phenomenon, which is related to the peculiar energy level structure of the complexes. Moreover, the fourfold anisotropy of the complex has been exploited to design a rotating magnetocaloric experiment showing that tetragonal anisotropy holds great potential to engineer a new class of more efficient magnetic refrigerants.}, archive = {J_ANGEW}, author = {Leonardo Tacconi and Anna S. Manvell and Matteo Briganti and Dominik Czernia and Høgni Weihe and Piotr Konieczny and Jesper Bendix and Mauro Perfetti}, doi = {10.1002/anie.202417582}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417582}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploiting high order magnetic anisotropy for advanced magnetocaloric refrigerants}, volume = {64}, year = {2025}, }
• (2025). Pd(0)/Pd(II) electromerism triggered by lewis base coordination to a redox-active silicon Z-type ligand. ANGEW, 64(5), e202417581. (www)

  @article{ , abstract = {Electromerism (aka. valence tautomerism) corresponds to the switching of electronic distributions between redox-active ligands and central elements. While this phenomenon is well established for several transition metals, the Pd(0)/Pd(II) couple could not yet be involved due to the high energy of the Pd(0) state. In this study, we present Pd(0)/Pd(II) electromerism by using a redox-active bis(phosphanyl-amidophenolato)silane. Strong silicon-based Z-type interaction stabilizes the Pd(0) state with an oxidized dicationic open-shell singlet ligand while binding of a Lewis base at the Lewis acidic silicon results in the loss of Z-type interaction and the intramolecular rearrangement to the Pd(II)/reduced ligand electromer. It introduces a novel concept for spin state switching by combining ligand ambiphilicity and redox activity.}, archive = {J_ANGEW}, author = {Nils Ansmann and Marion Kerscher and Lutz Greb}, doi = {10.1002/anie.202417581}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417581}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pd(0)/Pd(II) electromerism triggered by lewis base coordination to a redox-active silicon Z-type ligand}, volume = {64}, year = {2025}, }
• (2025). Enhanced coplanarity and giant birefringence in hydroxypyridinium nitrate via hydrogen bonding between planar donors and planar acceptors. ANGEW, 64(5), e202417579. (www)

  @article{ , abstract = {Birefringent crystals, which possess optical anisotropy, are important optical components. However, designing and synthesizing birefringent crystals faces the challenge of achieving anisotropic structures, especially coplanar geometries. Herein, we achieve a significant birefringence in an ionic compound (C 5 H 6 ON) + (NO 3 ) − , (4-hydroxypyridinium nitrate, 4HPN) by hydrogen bonding between planar donors and planar acceptors. We demonstrate that the interactions between the planar hydrogen bond donor ((C 5 H 6 ON) + ) and planar hydrogen bond acceptor ((NO 3 ) − ) ensure the coplanarity during the crystal packing, generating the desired giant optical anisotropy. On two manually cut crystal chips, we observe a =0.494 ( =0.593), which is the largest among nitrates, or hydroxypyridinium derivatives. This value already surpasses those of the benchmark crystals, e.g., YVO 4 and CaCO 3 , commonly used in the UV to visible and near IR spectral range. 4HPN also exhibits a strong second harmonic generation response (9.55×KDP). This strategy offers a promising avenue for the design and development of birefringent crystals with potential applications in optical communication, sensing and signal processing devices.}, archive = {J_ANGEW}, author = {Jian-Ping Yin and Jingyu Guo and Hao Huo and Xin Liu and Xue-Jie Cheng and Zheshuai Lin and Li-Ming Wu and Ling Chen}, doi = {10.1002/anie.202417579}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced coplanarity and giant birefringence in hydroxypyridinium nitrate via hydrogen bonding between planar donors and planar acceptors}, volume = {64}, year = {2025}, }
• (2025). Fabrication of hierarchical nanostructures featuring amplified asymmetry through co-assembly of liquid crystalline block copolymer and chiral amphiphiles. ANGEW, 64(5), e202417573. (www)

  @article{ , abstract = {The widespread presence of hierarchical asymmetric structures in nature has sparked considerable interest because of their unique functionalities. These ingenious structures across multiple scales often emerge from the transfer and amplification of asymmetry from chiral molecules under various synergistic effects. However, constructing artificial chiral asymmetric structures, particularly in developing hierarchical multicomponent structures analogous to those formed in nature through synergistic non-covalent interactions, still presents tremendous challenges. Herein, we propose a co-assembly strategy to fabricate hierarchical chiral mesostructures by combining a liquid crystalline block copolymer (LC-BCP) with a small molecular amphiphile containing chiral alanine or phenylalanine as a linker. Through a classic solvent-exchange process, chiral amphiphiles embedded within LC-BCP finely regulate the LC ordering effect and facilitate transfer and amplification of asymmetry. Consequently, various co-assembled structures with significant hierarchical chirality features are obtained through synergetic effects. Remarkably, subtle alterations to the side groups of amino acids in the amphiphiles effectively adjust the hierarchical morphology transition. Moreover, the covalent bonding sequence of amino acids in the amphiphiles emerges as a critical factor governing the formation of hierarchical nanofibers and multilayered vesicles exhibiting a superhelical sense.}, archive = {J_ANGEW}, author = {Yue Lu and Yangge Ren and Juanjuan Gao and Tiantian Cai and Linyuan Liu and Yi Ding and Qingbin Xie and Lin Jia}, doi = {10.1002/anie.202417573}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417573}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fabrication of hierarchical nanostructures featuring amplified asymmetry through co-assembly of liquid crystalline block copolymer and chiral amphiphiles}, volume = {64}, year = {2025}, }
• (2025). A mechanical immune checkpoint inhibitor stiffens tumor cells to potentiate antitumor immunity. ANGEW, 64(5), e202417518. (www)

  @article{ , abstract = {Tumor progression is associated with tumor-cell softening. Improving the stiffness of the tumor cells can make them more vulnerable to lymphocyte-mediated attack. Tumor cell membranes typically exhibit higher cholesterol levels than normal cells, making tumor cells soft. Herein, we demonstrate a mechanical immune checkpoint inhibitor (MICI) formulated by cyclodextrin (CD) lipids and fusogenic lipids. Through fusing CD lipids into the tumor cell membrane using a fusogenic liposome formulation, the cholesterol in the plasma membrane is reduced due to the specific host–guest interactions between CD lipid and cholesterol. As a result, tumor cells are stiffened, and the activation of lymphocytes (including NK and cytotoxic effector T cells) is improved when contacting the stiffened tumor cells, characterized by robust degranulation and effector cytokine production. Notably, this treatment has negligible influence on the infiltration and proliferation of lymphocytes in tumor tissues, confirming that the enhanced antitumor efficacy should result from activating a specific number of lymphocytes caused by direct regulation of the tumor cell stiffness. The combination of MICIs and clinical immunotherapies enhances the lymphocyte-mediated antitumor effects in two tumor mouse models, including breast cancer and melanoma. Our research also reveals an unappreciated mechanical dimension to lymphocyte activation.}, archive = {J_ANGEW}, author = {Yu Zhao and Xiaoxue Hou and Zeyu Wang and Shiyu Peng and Chunxiong Zheng and Qingqing Huang and Yufei Ma and Yuanfeng Li and Yong Liu and Yang Liu and Linqi Shi and Fan Huang}, doi = {10.1002/anie.202417518}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417518}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A mechanical immune checkpoint inhibitor stiffens tumor cells to potentiate antitumor immunity}, volume = {64}, year = {2025}, }
• (2025). Non-selective defect minimization towards highly efficient metal-organic framework membranes for gas separation. ANGEW, 64(5), e202417513. (www)

  @article{ , abstract = {The persistence of defects in polycrystalline membranes poses a substantial obstacle to reaching the theoretical molecular sieving separation and scaling up production. The low membrane selectivity in most reported literature is largely due to the unavoidable non-selective defects during synthesis, leading to a mismatch between the well-defined pore structure of polycrystalline molecular sieve materials. This paper presents a novel approach for minimizing non-selective defects in metal–organic framework (MOF) membranes by a constricted crystal growth strategy in a confined environment. The in situ ZIF formation using the densely packed seeding array between the substrate and the pre-grown top ZIF layer yields a confined membrane interlayer, which is highly uniform with a tightly packed crystalline structure. Unlike uncontrolled crystal growth, we purposely regulate the interlayer membrane growth in the direction parallel to the substrate. A notable 99 % decrease in defects in the confined interlayer was achieved compared to the random-grown top layer, leading to a ~353 % increment in H 2 /N 2 selectivity over the non-confined reference MOF membrane. The performance of this new membrane sits in the optimal range above the Robeson upper bound. The membrane boasts a balanced high H 2 permeability (>5000 Barrer) and selectivity (>50), significantly surpassing peer ZIF membranes.}, archive = {J_ANGEW}, author = {Fatereh Dorosti and Lei Ge and Hao Wang and John Bell and Rijia Lin and Jingwei Hou and Zhonghua Zhu}, doi = {10.1002/anie.202417513}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417513}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-selective defect minimization towards highly efficient metal-organic framework membranes for gas separation}, volume = {64}, year = {2025}, }
• (2025). Targeting lysosomal thiols for immunogenic cancer cell death. ANGEW, 64(5), e202417509. (www)

  @article{ , abstract = {The number and stability of lysosomes (LYs) are different in cancer and healthy cells that makes them a possible target for cancer specific therapy. However, no LY-targeting drug is clinically approved yet. We describe in this paper a new therapeutic approach based on alkylation of lysosomal thiols in cancer cells by reversible thiol binder 11 . The treatment with 11 increases the level of lysosomal reactive oxygen species leading to their destabilization, disruption and immunogenic cancer cell death. These effects are not observed in healthy cells. In murine sarcoma Nemeth-Kellner (NK)/Ly-RB model, 11 exhibits the spectacular therapeutic effect: it extends the lifespan of the treated mice from 21 to 85 days and cures 40 % of mice. The survived mice develop antibodies against tumor NK/Ly-RB cells. Their repeated challenge with the NK/Ly-RB cells results in 100 % mice survival compared to 0 % survival in the control group of naïve mice. Ex vivo data indicate that neutrophils in spleen of the cured animals are also involved in targeting cancer cells and produce neutrophil extracellular traps. In summary, 11 induces the direct antitumor effect supported by humoral immune responses, as well as priming neutrophil's reaction against tumors.}, archive = {J_ANGEW}, author = {Anton Arkhypov and Insa Klemt and Galyna Bila and Dina Attia and Svitlana Chernii and Rostyslav Bilyy and Andriy Mokhir}, doi = {10.1002/anie.202417509}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417509}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Targeting lysosomal thiols for immunogenic cancer cell death}, volume = {64}, year = {2025}, }
• (2025). Integrating multiple redox-active units into conductive covalent organic frameworks for high-performance sodium-ion batteries. ANGEW, 64(5), e202417493. (www)

  @article{ , abstract = {The rational design of porous covalent organic frameworks (COFs) with high conductivity and reversible redox activity is the key to improving their performance in sodium-ion batteries (SIBs). Herein, we report a series of COFs (FPDC-TPA-COF, FPDC-TPB-COF, and FPDC-TPT-COF) based on an organosulfur linker, (trioxocyclohexane-triylidene)tris(dithiole-diylylidene))hexabenzaldehyde (FPDC). These COFs feature two-dimensional crystalline structures, high porosity, good conductivity, and densely packed redox-active sites, making them suitable for energy storage devices. Among them, FPDC-TPT-COF demonstrates a remarkably high specific capacity of 420 mAh g −1 (0.2 A g −1 ), excellent cycling stability (~87 % capacity retention after 3000 cycles, 1.0 A g −1 ) and high rate performance (339 mAh g −1 at 2.0 A g −1 ) as an anode for SIBs, surpassing most reported COF-based electrodes. The superior performance is attributed to the dithiole moieties enhancing the conductivity and the presence of redox-active carbonyl, imine, and triazine sites facilitating Na storage. Furthermore, the sodiation mechanism was elucidated through in situ experiments and density functional theory (DFT) calculations. This work highlights the advantages of integrating multiple functional groups into redox-active COFs for the rational design of efficient and stable SIBs.}, archive = {J_ANGEW}, author = {Si-Wen Ke and Wei Li and Lei Gao and Jian Su and Rengan Luo and Shuai Yuan and Ping He and Jing-Lin Zuo}, doi = {10.1002/anie.202417493}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating multiple redox-active units into conductive covalent organic frameworks for high-performance sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). A well-coupled supramolecular system accelerates photophosphorylation. ANGEW, 64(5), e202417474. (www)

  @article{ , abstract = {Supramolecular assembly allows multiple chemical/bio-components integrated as one system for cascade biochemical reactions. Herein the graphitic carbon nitrides (g-C 3 N 4 ) as photocatalyst trapped in a dipeptide hydrogel covering adenosine triphosphate (ATP) synthase accelerates the photophosphorylation through ATP synthesis. Self-assembled N -fluorenylmethoxycarbonyl diphenylalanine (Fmoc-FF) as nanofibrils to allow g-C 3 N 4 nanosheets are embedded as a complex Fmoc-FF/g-C 3 N 4 hydrogel. Fmoc-FF gel exhibits good electronic coupling with g-C 3 N 4 , which enables a photo-induced proton generation. The transmembrane proton gradient can be established by ATP synthase-lipid reconstituted on the surface of the Fmoc-FF/g-C 3 N 4 hydrogel to enhance the ATP synthesis. It indicates that the Fmoc-FF/g-C 3 N 4 /ATP synthase-lipid film can possess a longer-term ATP production capability and allow repeated immersion for sustained ATP production. Such a hydrogel-supported ATP synthesis platform is achieved by a procedure at a larger scale.}, archive = {J_ANGEW}, author = {Zibo Li and Fanchen Yu and Shuhao Wang and Yuyang Cai and Yang Xu and Yue Li and Jinbo Fei and Junbai Li}, doi = {10.1002/anie.202417474}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417474}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A well-coupled supramolecular system accelerates photophosphorylation}, volume = {64}, year = {2025}, }
• (2025). Long-lifespan 522 wh kg−1 lithium metal pouch cell enabled by compound additives engineering. ANGEW, 64(5), e202417471. (www)

  @article{ , abstract = {Matching high-voltage cathodes with lithium metal anodes represents the most viable technological approach for developing secondary batteries with ultra-high energy density exceeding 500 Wh kg −1 . Nevertheless, the instability of electrolyte/electrode interface film and commercial electrolytes with cut-off voltage above 4.3 V is still a major concern. Herein, we present that excellent cycling stability with an ultra-high cut-off voltage of up to 5.0 V can be obtained by using three-component additives containing fluoroethylene carbonate (FEC), hexadecyl trimethylammonium chloride (CTAC), and tri(pentafluorophenyl)borane (TPFPB). Excellent ionic conductivity, robust interfacial films on both electrodes, and long-lasting uniform Li + regulation ability can be obtained in the modifying electrolyte. Consequently, using a high plating/stripping capacity of 3 mAh cm −2 under the current density of 1 mA cm −2 , lithium symmetric cells demonstrate stable cycling performance exceeding 800 hours. Meanwhile, the 7.3 Ah-class Li[Ni x Co y Mn 1-x-y ]O 2 ( x =0.83, NCM83)|Li pouch cells are assembled, which show a high energy density of 522 Wh kg −1 and present excellent stability over 178 cycles with a high initial coulombic efficiency (CE) of 98.0 %.}, archive = {J_ANGEW}, author = {Tingxuan Tang and Chuang Sun and Yong Li and Minman Tong and Jun Lu and Chao Lai}, doi = {10.1002/anie.202417471}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417471}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Long-lifespan 522 wh kg−1 lithium metal pouch cell enabled by compound additives engineering}, volume = {64}, year = {2025}, }
• (2025). Ultra-wide modulation and reversible reconfiguration of a flexible organic crystalline optical waveguide between 645 and 731 nm. ANGEW, 64(5), e202417459. (www)

  @article{ , abstract = {Flexible organic crystalline optical waveguides, which deliver input or self-emit light through various dynamic organic crystals, have attracted increasing attention in the past decade. However, the modulation of the waveguide output relies on chemical design and substituent modification, being time-consuming and laborious. Here we report an elastic organic crystal that displays long-distance light transduction up to 2.0 cm and an ultra-wide modulation of crystalline optical waveguides between red (645 nm) and near infrared (731 nm) in both the pristine and the elastically bent states based on a pre-designed self-absorption effect. The flexible organic crystalline optical waveguides can be precisely and reversibly reconfigured by controlling the irradiation point. In addition, deep-red amplified spontaneous emission (ASE) that is able to transduce through a 5.0 mm bent crystal with an ultra-low optical loss coefficient of 0.093 dB/mm has been attained. To the best of our knowledge, this is the first report of flexible organic ASE waveguides. The present study not only provides a simple yet effective strategy to remarkably modulate flexible organic crystalline optical waveguides but also demonstrates the superiority of lasing over normal emission as flexible optical communication elements.}, archive = {J_ANGEW}, author = {Quanliang Chen and Baolei Tang and Kaiqi Ye and Hanlin Hu and Hongyu Zhang}, doi = {10.1002/anie.202417459}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-wide modulation and reversible reconfiguration of a flexible organic crystalline optical waveguide between 645 and 731 nm}, volume = {64}, year = {2025}, }
• (2025). Switchable topologically chiral [2]Catenane as multiple resonance thermally activated delayed fluorescence emitter for efficient circularly polarized electroluminescence. ANGEW, 64(5), e202417458. (www)

  @article{ , abstract = {Aiming at the fabrication of circularly polarized organic light-emitting diodes (CP-OLEDs) with high dissymmetry factors ( g EL ) and color purity through the employment of novel chiral source, topologically chiral [2]catenanes were first utilized as the key chiral skeleton to construct novel multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters. Impressively, the efficient chirality induction and unique switchable feature of topologically chiral [2]catenane not only lead to a high | g PL | value up to 1.6×10 −2 but also facilitate in situ dynamic switching of the full-width at half-maximum (FWHM) and circularly polarized luminescence (CPL). Furthermore, the solution-processed CP-OLEDs based on the resultant topologically chiral emitters exhibit a narrow FWHM of 36 nm, maximum external quantum efficiency of 17.6 %, and CPEL with | g EL | of 2.1×10 −3 . This study demonstrates the successful construction of the first CP-MR-TADF emitters based on topological chirality with the highest | g PL | among the reported CP-MR-TADF emitters and excellent device performance to the best of our knowledge. Moreover, it endowed the MR-TADF emitter with distinctive switchable CPL performances, thus providing a novel design strategy as well as a promising platform for developing intelligent CP-OLEDs.}, archive = {J_ANGEW}, author = {Yu Wang and Wen-Long Zhao and Zhiwen Gao and Cheng Qu and Xue Li and Yefei Jiang and Lianrui Hu and Xu-Qing Wang and Meng Li and Wei Wang and Chuan-Feng Chen and Hai-Bo Yang}, doi = {10.1002/anie.202417458}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417458}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switchable topologically chiral [2]Catenane as multiple resonance thermally activated delayed fluorescence emitter for efficient circularly polarized electroluminescence}, volume = {64}, year = {2025}, }
• (2025). Unconventional near-equilibrium nucleation of graphene on si-terminated SiC(0001) surface. ANGEW, 64(5), e202417457. (www)

  @article{ , abstract = {The transfer-free character of graphene growth on Silicon Carbide (SiC) makes it compatible with state-of-the-art Si semiconductor technologies for directly fabricating high-end electronics. Although significant progress has been achieved in epitaxial growth of graphene on SiC recently, the underlying nucleation mechanism remains elusive. Here, we present a theoretical study to elucidate graphene near-equilibrium nucleation on Si-terminated hexagonal-SiC(0001) surface. It is found that the ultra-large lattice mismatch between SiC(0001) surface and graphene and the highly localized electron distribution on SiC(0001) surface lead to a distinctive nucleation process: (i) Most of the magic carbon clusters on SiC(0001) show only C 1 symmetry and are mainly composed of pentagonal rings; (ii) Two possible nucleation pathways are revealed, i.e ., longitudinal and circular modes; (iii) Carbon clusters are more stable on flat terraces than near atomic step edges. Based on above findings, a graphene nucleation diagram on SiC(0001) is established and experimentally observed contradictories for graphene growth on SiC(0001) are answered. Our in-depth understanding on graphene nucleation on SiC(0001) extends nucleation mechanisms of 2D crystals and will benefit high-quality graphene growth on SiC(0001).}, archive = {J_ANGEW}, author = {Haojie Huang and Zebin Ren and Xiao Xue and Haoyuancheng Guo and Jianyi Chen and Yunlong Guo and Yunqi Liu and Jichen Dong}, doi = {10.1002/anie.202417457}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417457}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unconventional near-equilibrium nucleation of graphene on si-terminated SiC(0001) surface}, volume = {64}, year = {2025}, }
• (2025). Iodine boosted fluoro-organic borate electrolytes enabling fluent ion-conductive solid electrolyte interphase for high-performance magnesium metal batteries. ANGEW, 64(5), e202417450. (www)

  @article{ , abstract = {Rechargeable magnesium batteries are regarded as a promising multi-valent battery system for low-cost and sustainable energy storage applications. Boron-based organic magnesium salts with terminal substituent fluorinated anions (Mg[B(OR F ) 4 ] 2 , R F =fluorinated alkyl) have exhibited impressive electrochemical stability and oxidative stability. Nevertheless, their deployment is hindered by the complicated synthesis routes and the surface passivation of Mg metal anode. Herein, we report the design of an advanced electrolyte formulation comprised of tri(hexafluoroisopropyl) borate (B(HFIP) 3 ) and iodine (I 2 ) in 1,2-dimethoxyethane (DME) solvent, which eventually convert into a Mg[B(HFIP) 4 ] 2 /DME-MgI 2 electrolyte system upon interacting with Mg anode. The Mg anode reacts with I 2 and the electron-accepting B(HFIP) 3 , leading to the in situ formation of a solid-electrolyte interphase layer composed of MgF 2 and MgI 2 species that can facilitate fast and stable Mg plating/stripping. Compared with the pristine Mg[B(HFIP) 4 ] 2 /DME electrolyte, the Mg[B(HFIP) 4 ] 2 /DME-MgI 2 electrolyte exhibited superior electrochemical performance including an ultra-low overpotential (~80 mV), high Coulombic efficiency and a long-cycling period over 1500 h. In result, the rechargeable magnesium batteries with Mg[B(HFIP) 4 ] 2 /DME-MgI 2 electrolyte and Chevrel-phase Mo 6 S 8 cathode show outstanding compatibility, rapid kinetics, and stable cyclability for over 1200 cycles, surpassing all previously reported boron-based electrolytes. This work introduces a promising halogen-enhancement strategy for boron-based Mg-ion electrolytes, with the overarching goal of establishing favorable solid-electrolyte interphases that are pivotal for the advancement and optimization of multi-valent secondary batteries.}, archive = {J_ANGEW}, author = {Xinmei Song and Jingjie Sun and Wen Ren and Lei Wang and Binze Yang and Hailong Ning and Pengbo Zhang and Zhuoma Caixiang and Zuoxiu Tie and Xuejin Zhang and Yanna NuLi and Zhong Jin}, doi = {10.1002/anie.202417450}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417450}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iodine boosted fluoro-organic borate electrolytes enabling fluent ion-conductive solid electrolyte interphase for high-performance magnesium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Interweavable metalloporphyrin-based fibers for indirect electrocatalysis. ANGEW, 64(5), e202417439. (www)

  @article{ , abstract = {The applications of indirect electrocatalysis toward potential industrial processes are drastically limited by the utilization or processing forms of electrocatalysts. The remaining challenges of electrocatalysts like the recycling in homogeneous systems or pulverization in heterogeneous systems call for advanced processing forms to meet the desired requirements. Here, we report a series of metalloporphyrin-based polymer fibers (M−PF, M=Ni, Cu and Zn) through a rigid-flexible polymerization strategy based on rigid metalloporphyrin and flexible thiourea units that can be applied as heterogeneous redox-mediators in indirect electrocatalysis. These functional fibers with high strength and flexibility exhibit interweavable and designable functions that can be processed into different fiber-forms like knotted, two-spiral, three-ply, five-ply fibers or even interweaved networks. Interestingly, they can be readily applied in S−S bond cleaving/cyclization reaction or extended oxidative self-coupling reaction of thiols with high efficiency. Remarkably, it enables the scale-up production (1.25 g in a batch-experiment) under laboratory conditions.}, archive = {J_ANGEW}, author = {Xiaoman Yao and Gang Liu and Yingying Huang and Caier Huang and Xuanxu Chen and Zhe Xuan and Mingjin Shi and Yiwen Yang and Xianqiang Huang and Yifa Chen and Ya-Qian Lan}, doi = {10.1002/anie.202417439}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417439}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interweavable metalloporphyrin-based fibers for indirect electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Tailoring d-band center of single-atom nickel sites for boosted photocatalytic reduction of diluted CO2 from flue gas. ANGEW, 64(5), e202417435. (www)

  @article{ , abstract = {Photocatalytic reduction of diluted CO 2 from anthropogenic sources holds tremendous potential for achieving carbon neutrality, while the huge barrier to forming *COOH key intermediate considerably limits catalytic effectiveness. Herein, via coordination engineering of atomically scattered Ni sites in conductive metal–organic frameworks (CMOFs), we propose a facile strategy for tailoring the d-band center of metal active sites towards high-efficiency photoreduction of diluted CO 2 . Under visible-light irradiation in pure CO 2 , CMOFs with Ni-O 4 sites (Ni-O 4 CMOFs) exhibits an outstanding rate for CO generation of 13.3 μmol h −1 with a selectivity of 94.5 %, which is almost double that of its isostructural counterpart with traditional Ni-N 4 sites (Ni-N 4 CMOFs), outperforming most reported systems under comparable conditions. Interestingly, in simulated flue gas, the CO selectivity of Ni-N 4 CMOFs decreases significantly while that of Ni-O 4 CMOFs is mostly unchanged, signifying the supremacy for Ni-O 4 CMOFs in leveraging anthropogenic diluted CO 2 . In situ spectroscopy and density functional theory (DFT) investigations demonstrate that O coordination can move the center of the Ni sites′ d-band closer to the Fermi level, benefiting the generation of *COOH key intermediate as well as the desorption of *CO and hence leading to significantly boosted activity and selectivity for CO 2 -to-CO photoreduction.}, archive = {J_ANGEW}, author = {Jiahui Liu and Bin Han and Xueming Liu and Shujie Liang and Yang Fu and Jun He and Lai-Hon Chung and Yuanfang Lin and Yupeng Wei and Sibo Wang and Tianyi Ma and Zhifeng Yang}, doi = {10.1002/anie.202417435}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417435}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring d-band center of single-atom nickel sites for boosted photocatalytic reduction of diluted CO2 from flue gas}, volume = {64}, year = {2025}, }
• (2025). Surface coordination chemistry of graphitic carbon nitride from ag molecular probes. ANGEW, 64(5), e202417428. (www)

  @article{ , abstract = {Graphitic carbon nitride (g-C 3 N 4 ) has gained significant attention for its catalytic properties, especially in the development of Single Atom Catalysts (SACs). However, the surface chemistry underlying the formation of these isolated metal sites remains poorly understood. In this study we employ Surface OrganoMetallic Chemistry (SOMC) together with advanced microscopic and spectroscopic techniques for an in-depth analysis of functionalized g-C 3 N 4 materials, where tailored organosilver probe molecules are used to monitor surface processes and characterize resulting surface species. A multi-technique approach – including high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) , X-ray absorption spectroscopy (XAS), and multinuclear solid-state Nuclear Magnetic Resonance spectroscopy (ssNMR), coupled with density functional theory (DFT) calculations – identifies three primary surface species in Ag-functionalized g-C 3 N 4 : bis -NHC-Ag + , dispersed Ag + sites, and physisorbed molecular precursor. These findings highlight a dynamic grafting process and provide insights into the surface coordination chemistry of functionalized g-C 3 N 4 materials.}, archive = {J_ANGEW}, author = {Sk Amanullah and Weicheng Cao and Enzo Brack and Milivoj Plodinec and Christophe Copéret}, doi = {10.1002/anie.202417428}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417428}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface coordination chemistry of graphitic carbon nitride from ag molecular probes}, volume = {64}, year = {2025}, }
• (2025). Stabilisation of bromenium ions in macrocyclic halogen bond complexes. ANGEW, 64(5), e202417427. (www)

  @article{ , abstract = {Halenium ions (X + ) are highly reactive electron deficient species that are prevalent transient intermediates in halogenation reactions. The stabilisation of these species is especially challenging, with the most common approach to sequester reactivity through the formation of bis-pyridine (Py) complexes; [(Py) 2 X] + . Herein, we present the first example of a macrocyclic stabilisation effect for halenium species. Exploiting a series of bis-pyridine macrocycles, we demonstrate that preorganised macrocyclic ligands stabilise bromenium cations via endotopic complexation, impressively facilitating the isolation of a bench stable ‘Br + NO 3 − ’ species. Solid state X-ray crystallographic structural comparison of macrocyclic Br(I) complexes with Ag(I) and Au(I) analogues provides insightful information concerning similarities and stark contrasts in halenium/metal cation coordination behaviors. Furthermore, the first chemical ligand exchange reactions of Br(I) complexes are reported between acyclic [(Py) 2 Br] + species and a bis-pyridine macrocyclic donor ligand which importantly highlights a macrocycle effect for halenium cation stabilisation in the solution phase.}, archive = {J_ANGEW}, author = {Andrew Docker and Heike Kuhn and Paul D. Beer}, doi = {10.1002/anie.202417427}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417427}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilisation of bromenium ions in macrocyclic halogen bond complexes}, volume = {64}, year = {2025}, }
• (2025). Triplet energy gap-regulated room temperature phosphorescence in Host–Guest doped systems. ANGEW, 64(5), e202417426. (www)

  @article{ , abstract = {The organic room temperature phosphorescence (RTP) materials via host–guest doped method receive considerable attention in the fields of optoelectronics, bioimaging, and information encryption. Despite many host–guest doped materials with excellent RTP properties have been developed, their luminous mechanism is still limited. Here, a series of host–guest doped materials, using benzophenone as the host and quinone compounds as the guests, were constructed to investigate the effect of the triplet energy gap (Δ E T ) between the host and guest on triplet states population. The guest's triplet state is proposed to be a “triplet energy reservoir”, gathering the triplet excitons to emit RTP when Δ E T is large and returning triplet excitons to the host when Δ E T is small. By combining the results of steady-state and delayed emission spectra, time-resolved transient absorption spectra, and theoretical calculations, a bidirectional energy transfer process is proved, which are triplet-triplet energy transfer and reverse triplet-triplet energy transfer processes. The thermal equilibrium of these two energy transfer processes can be regulated by the Δ E T and temperature. The potential applications of these RTP properties are also realized in data encryption and anti-counterfeiting. This work provides valuable insight into the design of host–guest doped materials based on energy transfer mechanisms.}, archive = {J_ANGEW}, author = {Jiayu Li and Subin Hao and Mengke Li and Yanqi Chen and Hailin Li and Shiqi Wu and Sirui Yang and Li Dang and Shi-Jian Su and Ming-De Li}, doi = {10.1002/anie.202417426}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triplet energy gap-regulated room temperature phosphorescence in Host–Guest doped systems}, volume = {64}, year = {2025}, }
• (2025). Fe-catalyzed α-C(sp3)−H amination of N-heterocycles. ANGEW, 64(5), e202417414. (www)

  @article{ , abstract = {Nitrogen-heterocycles are privileged structures in both marketed drugs and natural products. On the other hand, C−H amination reactions furnish unconventional and straightforward approaches for the construction of C−N bonds. Yet, most of the known methods rely on precious metal catalysts. Herein we report a site-selective intermolecular C(sp 3 )−H amination of N-heterocycles, catalyzed by inexpensive FeCl 2, which allows the functionalization of a wide range of pharmaceutically relevant cyclic amines. The C−H amination occurs site-selectively in α-position to the nitrogen atom, even when weaker C−H bonds are present, and furnishes Troc-protected aminals or amidines. The method employs the N-heterocycle as limiting reagent and is applicable to the late-stage functionalization of complex molecules. Its synthetic potential was further illustrated through the derivatization of α-aminated products and the application to a concise total synthesis of the reported structure for senobtusin. Mechanistic studies allowed to propose a plausible reaction mechanism involving a turnover-limiting Fe-nitrene generation followed by fast H atom transfer and radical rebound.}, archive = {J_ANGEW}, author = {Andrea Geraci and Olivier Baudoin}, doi = {10.1002/anie.202417414}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417414}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fe-catalyzed α-C(sp3)−H amination of N-heterocycles}, volume = {64}, year = {2025}, }
• (2025). Precise photochemical post-processing of molecular crystals. ANGEW, 64(5), e202417409. (www)

  @article{ , abstract = {Molecular crystals carry a great potential as new soft smart materials, with a plethora of recent examples overcoming the major obstacle of mechanical flexibility, and this research direction holds enormous potential to revolutionize optics, electronics, medicine, and space exploration. However, shaping organic crystals into desired shapes and sizes remains a major practical challenge due to the lack of control over the crystallization process, and the difficulties in mechanical post-processing without introduction of defects that are usually imparted by their soft nature. Here we present an innovative approach that employs photochemical processing for precise and nondestructive cutting of a molecular crystal. Our proposed method uses light to post-process crystals of the desired size and shape, similar to using light to cut other materials. This reaction induces strain, ensuring sharp cleavage without the need for melting or other processes. We further demonstrate the potential of this approach by producing crystals of arbitrary size, which can be used as controllable optical waveguides. Among other potential applications, this method can be used to prepare dynamic crystals, particularly those with aspect ratios crucial for mechanical deformation, such as flexible electronics, soft robotics, and sensing.}, archive = {J_ANGEW}, author = {Jianqun Qi and Linfeng Lan and Quanliang Chen and Liang Li and Panče Naumov and Hongyu Zhang}, doi = {10.1002/anie.202417409}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417409}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise photochemical post-processing of molecular crystals}, volume = {64}, year = {2025}, }
• (2025). Modulating core polarity in metal-free covalent organic frameworks for selective electrocatalytic hydrogen peroxide production. ANGEW, 64(5), e202417403. (www)

  @article{ , abstract = {Tuning the charge density at the active site to balance the adsorption ability and reactivity of oxygen is extremely significant for driving a two-electron oxygen reduction reaction (ORR) to produce hydrogen peroxide (H 2 O 2 ). Herein, we have highlighted the influence of intermolecular polarity in covalent organic frameworks (COFs) on the efficiency and selectivity of electrochemical H 2 O 2 production. Different C3 symmetric building blocks have been utilized to regulate the charge density at the active sites. The benzene-cored COF, which exhibits reduced polarity than the triazine-cored COF, displayed enhanced performance in H 2 O 2 production, achieving 93.1 % selectivity for H 2 O 2 at 0.4 V with almost two-electron transfer and a faradaic efficiency of 90.5 %. In-situ electrochemical Raman spectroscopy and scanning electrochemical microscopy (SECM) were employed to confirm H 2 O 2 generation and analyze spatial reactivity patterns. These techniques provided detailed insights into localized catalytic behavior, emphasizing the influence of core polarity.}, archive = {J_ANGEW}, author = {Shivangi Mehta and Nada Elmerhi and Sukhjot Kaur and Abdul Khayum Mohammed and Tharamani C. Nagaiah and Dinesh Shetty}, doi = {10.1002/anie.202417403}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417403}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating core polarity in metal-free covalent organic frameworks for selective electrocatalytic hydrogen peroxide production}, volume = {64}, year = {2025}, }
• (2025). Nickel dynamics switches the selectivity of CO2 hydrogenation. ANGEW, 64(5), e202417392. (www)

  @article{ , abstract = {The Reverse Water Gas-Shift reaction (CO 2 +H 2 CO+H 2 O) allows to balance syn-gas under industrial conditions. Nickel has been suggested as a potential catalyst but the temperature required is too high, more than 800 °C, limiting practical implementation but when lowering the temperature methanation occurs. Simulations via Density Functional Theory on well-defined surfaces have systematically failed to reproduce these experimental results. But under reaction conditions, Ni surfaces are not static and DFT models coupled to microkinetics show that low temperatures (high CO coverages) drive the generation of Ni adatoms that are the active sites for methanation. At higher temperatures, the adatom population decreases, and the selectivity towards CO increases. Thus the mechanism behind the selectivity switch is driven by the dynamics induced by reaction intermediates. Our work contributes to the inclusion of dynamic aspects of materials under reaction conditions in the understanding of complex catalytic behaviour.}, archive = {J_ANGEW}, author = {José Manuel González and Albert Sabadell-Rendón and Kamila Kaźmierczak and Florian Euzenat and Nicolas Montroussier and Daniel Curulla-Ferré and Núria López}, doi = {10.1002/anie.202417392}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417392}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel dynamics switches the selectivity of CO2 hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Engineering single ni sites on 3D cage-like cucurbit[n]uril ligands for efficient and selective CO2 photocatalytic reduction. ANGEW, 64(5), e202417384. (www)

  @article{ , abstract = {Solar-driven CO 2 selective reduction with high conversion is a challenging task yet holds immense promise for both CO 2 neutralization and green fuel production. Enhancing CO 2 adsorption at the catalytic centre can trigger a highly efficient CO 2 capture-to-conversion process. Herein, we introduce cucurbit[n]urils (CB[n]), a new family of molecular ligands, as a key component in the creation of a 3D cage-like metal (nickel, Ni)-complex molecular co-catalyst (CB[7]-Ni) for photocatalysis. It exhibits an unprecedented CO yield rate of 72.1 μmol ⋅ h −1 with a high selectivity of 97.9 % under visible light irradiation. To verify the origin of the carbon source in the products, a straightforward isotopic tracing method is designed based on tandem reactions. The catalytic process commences with photoelectron transfer from Ru(bpy) 3 2+ to the Ni 2+ site, resulting in the reduction of Ni 2+ to Ni + . The locally enriched CO 2 molecules in the cage ligand CB[7] undergo selective reduction by the Ni + nearby to form CO product. This work exemplifies the inspiring potential of ligand structure engineering in advancing the development of efficient unanchored molecular co-catalysts.}, archive = {J_ANGEW}, author = {Jingyi Wang and Xiyi Li and Chia-Hao Chang and Tianyu Zhang and Xuze Guan and Qiong Liu and Liquan Zhang and Ping Wen and Ivan Tang and Yuewen Zhang and Xiaofeng Yang and Junwang Tang and Yang Lan}, doi = {10.1002/anie.202417384}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417384}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering single ni sites on 3D cage-like cucurbit[n]uril ligands for efficient and selective CO2 photocatalytic reduction}, volume = {64}, year = {2025}, }
• (2025). Novel inorganic-organic dual-photosensitizing dinuclear-metal self-assembly system for efficient artificial photosynthesis without sacrificial electron donors. ANGEW, 64(5), e202417373. (www)

  @article{ , abstract = {Owing to the unique synergistic effect, dinuclear-metal-molecule-catalysts (DMCs) show excellent performance in catalytic fields. However, for overall photocatalytic CO 2 reaction (CO 2 RR), it is still a challenge to construct well-matched photosensitizer (PS) components for DMCs-based photocatalysts. Inorganic-quantum-dot PS possesses capacities of multiple exciton generation and catalyzing water oxidation but is incompatible with DMCs. In contrast, organic PS can be covalently linked with DMCs but inescapable of using sacrificial electron donors. For overall photocatalytic CO 2 RR, organic–inorganic dual-photosensitizing system might be a promising candidate. Herein, we employed covalent-linking and electrostatic-driven approaches to construct the self-assembly of pyrene-sensitized Co 2 L DMCs (Py-Co 2 L) and perovskite (PVK) quantum dots, i.e., PVK@[Py-Co 2 L]. Using H 2 O as an electron donor, PVK@[Py-Co 2 L] realized 105.24 μmol ⋅ g −1 ⋅h −1 CO yield in photocatalytic CO 2 RR, much higher than PVK (15.44 μmol ⋅ g −1 ⋅h −1 ) and PVK@Co 2 L (32.30 μmol ⋅ g −1 ⋅ h −1 ), ascribing to the efficient photogenerated charge separation and transfer. The experimental results and theoretical investigations demonstrated that the pyrene linked on Co 2 L boosted the electron delivery from PVK to DMCs. Besides, this strategy could also be extended to the photocatalytic H 2 evolution coupled with alcohol oxidation. As a proof-of-concept, our work lightens the integration of DMCs, organic and inorganic PS components, promoting the development of photocatalysis without sacrificial electron donors.}, archive = {J_ANGEW}, author = {Jiaxin Wang and Tianqun Song and Zheyuan Liu and Qinbai Yun and Juehan Sun and Ying Zhang and Kuo Yuan and Dichang Zhong and Zhiyong Tang and Tongbu Lu}, doi = {10.1002/anie.202417373}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417373}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Novel inorganic-organic dual-photosensitizing dinuclear-metal self-assembly system for efficient artificial photosynthesis without sacrificial electron donors}, volume = {64}, year = {2025}, }
• (2025). Selective nonenzymatic formation of biologically common RNA hairpins. ANGEW, 64(5), e202417370. (www)

  @article{ , abstract = {The prebiotic formation of RNA building blocks is well-supported experimentally, yet the emergence of sequence- and structure-specific RNA oligomers is generally attributed to biological selection via Darwinian evolution rather than prebiotic chemical selectivity. In this study, we used deep sequencing to investigate the partitioning of randomized RNA overhangs into ligated products by either splinted ligation or loop-closing ligation. Comprehensive sequence-reactivity profiles revealed that loop-closing ligation preferentially yields hairpin structures with loop sequences UNNG, CNNG, and GNNA (where N represents A, C, G, or U) under competing conditions. In contrast, splinted ligation products tended to be GC rich. Notably, the overhang sequences that preferentially partition to loop-closing ligation significantly overlap with the most common biological tetraloops, whereas the overhangs favoring splinted ligation exhibit an inverse correlation with biological tetraloops. Applying these sequence rules enables the high-efficiency assembly of functional ribozymes from short RNAs without template inhibition. Our findings suggest that the RNA tetraloop structures that are common in biology may have been predisposed and prevalent in the prebiotic pool of RNAs, prior to the advent of Darwinian evolution. We suggest that the one-step prebiotic chemical process of loop-closing ligation could have favored the emergence of the first RNA functions.}, archive = {J_ANGEW}, author = {Long-Fei Wu and Junting Zhang and Robert Cornwell-Arquitt and David A. Hendrix and Aleksandar Radakovic and Jack W. Szostak}, doi = {10.1002/anie.202417370}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417370}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective nonenzymatic formation of biologically common RNA hairpins}, volume = {64}, year = {2025}, }
• (2025). Self-adaptive activation of DNAzyme nanoassembly for synergistically combined gene therapy. ANGEW, 64(5), e202417363. (www)

  @article{ , abstract = {DNAzyme represents a promising gene silencing toolbox yet is obstructed by the poor substrate accessibility in specific cells. Herein, a compact DNA nanoassembly, incorporating multimeric therapeutic DNAzyme, was prepared for selective delivery of gene-silencing DNAzyme with requisite cofactors and auxiliary chemo-drugs. By virtue of the sequence-conservative duplex-specific nuclease, the endogenous miRNA catalyzes the successive and site-specific cleavage of DNA nanoassembly substrate (nominated as the localized RNA walking machine) and thus ensures the liberation/activation of therapeutic agents with high accuracy and efficacy. The miR-10b-stimulated DNAzyme was designed to downregulate the TWIST transcription factor, an upstream promotor of miR-10b, thus acquiring the self-sufficient downregulation of TWIST/miR-10b signaling nodes (self-adaptive negative feedback loop) for abrogating tumor metastasis and chemo-resistance issues.}, archive = {J_ANGEW}, author = {Jing Wang and Jinhua Shang and Shanshan Yu and Mengru Lin and Xue Gong and Xiaoqing Liu and Zhihong Liu and Fuan Wang}, doi = {10.1002/anie.202417363}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417363}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-adaptive activation of DNAzyme nanoassembly for synergistically combined gene therapy}, volume = {64}, year = {2025}, }
• (2025). Synthesis, stable radical anion and energy storage performance of pentacene tetraimides. ANGEW, 64(5), e202417362. (www)

  @article{ , abstract = {Imide functionalization has been widely proved to be an effective approach to enrich optoelectronic properties of polycyclic aromatic hydrocarbons (PAHs). However, appending multiple imide groups onto linear acenes is still a synthetic challenge. Herein, we demonstrate that by taking advantage of a “breaking and mending” strategy, a linear pentacene tetraimides (PeTI) was synthesized through a three-step sequence started from the naphthalene diimides (NDI). Compared with the parent pentacene, PeTI shows a deeper-lying lowest unoccupied molecular orbital (LUMO) energy level, narrower band gap and better stability. The redox behavior of PeTI was firstly evaluated by generating a stable radical anion specie with the assistance of cobaltocene (CoCp 2 ), and the structure of the electron transfer (ET) complex was confirmed by the X-ray crystallography. Moreover, due to the presence of multiple redox-active sites, we are able to show that the state-of-the-art energy storage performance of the dealkylated PeTI (designated as PeTCTI) in organic potassium ion batteries (OPIBs) as an anode. Our results shed light on the application of multiple imides functionalized linear acenes, and the reported synthetic strategy provides an effective way to get access to longer nanoribbon imides with fascinating electronic properties.}, archive = {J_ANGEW}, author = {Xiaoxiao You and Hang Liu and Hao Zhou and Xingyu Chen and Jingwen Xu and Dongxue Wang and Di Wu and Jianlong Xia}, doi = {10.1002/anie.202417362}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417362}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis, stable radical anion and energy storage performance of pentacene tetraimides}, volume = {64}, year = {2025}, }
• (2025). Autocatalysis-integrated bioorthogonal (Poly)Catalyst-linked immunosorbent assay for living cell membrane antigens. ANGEW, 64(5), e202417352. (www)

  @article{ , abstract = {Immunoassay methods, notably enzyme-linked immunosorbent assays (ELISAs), renowned for their signal amplification capabilities, are extensively employed in scientific research and clinical diagnostics. However, the instability of enzymes and their sensitivity to cellular environments present significant challenges for the broad application of ELISA in living cells. In this work, we present a bioorthogonal (poly)catalysis-linked immunosorbent assay (BCLISA) designed for the detection of cell membrane antigens, which involves coupling bioorthogonal catalysts based on small molecules or polymers to antibodies. After screening, we opted for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the core reaction system. The polymer-based catalysts exhibit enhanced reactivity at the same molecular concentration due to their multiple catalytic sites. Polytriazoles formed during the CuAAC reaction have the ability to chelate Cu(I), thereby promoting faster catalysis. By harnessing this autocatalytic feature, we successfully increased the signal amplification potential of BCLISA. Ultimately, this autocatalysis-integrated BCLISA technique was employed for antigen detection and imaging on both in vitro and living cell membranes. This approach offers a new method for the detection and imaging of low-abundance antigens on living cells.}, archive = {J_ANGEW}, author = {Xuepu Feng and Guoming Tong and Zengwei Ran and Xiaojuan Liu and Liang Li and Guhuan Liu and Ronghua Yang}, doi = {10.1002/anie.202417352}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417352}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Autocatalysis-integrated bioorthogonal (Poly)Catalyst-linked immunosorbent assay for living cell membrane antigens}, volume = {64}, year = {2025}, }
• (2025). Unveiling surface reconstruction as the primary trigger for capacity loss in ultra-high nickel cathodes. ANGEW, 64(5), e202417278. (www)

  @article{ , abstract = {Mechanical failures, such as cracks and nanopores, along with the associated surface reconstruction, have long been regarded as the primary causes of capacity decay in ultra-high Ni layered oxides. However, the impact of these failures on performance degradation has not yet been effectively elucidate and distinguished. Herein, we develop ultra-high Ni cathodes with tailored morphological structures by incorporating B and Mo to optimize lithiation kinetics, which can suppress lattice strain, particle cracking, and surface reconstruction during charging/discharging. And the role of chemo-mechanical failures in capacity loss is systematically investigated. Surprisingly, contrary to the traditional view, structural and electrochemical characterizations of the cycled cathodes demonstrate that intragranular cracks, intergranular cracks, and nanopores are not the primary contributing factors of capacity loss. Instead, surface reconstruction triggers rapid capacity decay. Notably, compared to nanopores, intragranular cracks expose a significantly larger quantity of active substances, thereby promoting interfacial side reactions and accelerating surface structural reconstruction during cycling.}, archive = {J_ANGEW}, author = {Lang Qiu and Mengke Zhang and Weibo Hua and Yi Wang and Yuting Deng and Zhuangzhi Li and Yang Song and Zhenguo Wu and Yao Xiao and Xiaodong Guo}, doi = {10.1002/anie.202417278}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417278}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling surface reconstruction as the primary trigger for capacity loss in ultra-high nickel cathodes}, volume = {64}, year = {2025}, }
• (2025). A kinetic scout approach accelerates targeted protein degrader development. ANGEW, 64(5), e202417272. (www)

  @article{ , abstract = {Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry, leading to an intensive focus on strategies that can accelerate their identification and optimization. We and others have previously used chemical proteomics to map degradable target space, and these datasets have been used to develop and train multiparameter models to extend degradability predictions across the proteome. In this study, we now turn our attention to develop generalizable chemistry strategies to accelerate the development of new bifunctional degraders. We implement lysine-targeted reversible-covalent chemistry to rationally tune the binding kinetics at the protein-of-interest across a set of 25 targets. We define an unbiased workflow consisting of global proteomics analysis, IP/MS of ternary complexes and the E-STUB assay, to mechanistically characterize the effects of ligand residence time on targeted protein degradation and formulate hypotheses about the rate-limiting step of degradation for each target. Our key finding is that target residence time is a major determinant of degrader activity, and this can be rapidly and rationally tuned through the synthesis of a minimal number of analogues to accelerate early degrader discovery and optimization.}, archive = {J_ANGEW}, author = {Angela T. Fan and Gillian E. Gadbois and Hai-Tsang Huang and Charu Chaudhry and Jiewei Jiang and Logan H. Sigua and Emily R. Smith and Sitong Wu and Grace J. Poirier and Kara Dunne-Dombrink and Pavitra Goyal and Andrew J. Tao and William R. Sellers and Eric S. Fischer and Katherine A. Donovan and Fleur M. Ferguson}, doi = {10.1002/anie.202417272}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417272}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A kinetic scout approach accelerates targeted protein degrader development}, volume = {64}, year = {2025}, }
• (2025). Corannulene-based quintuple [6]/[7]Helicenes: Well-preserved bowl core, inhibited bowl inversion and supramolecular assembly with fullerenes. ANGEW, 64(5), e202417269. (www)

  @article{ , abstract = {Herein, corannulene-based quintuple [6]helicenes ( Q[6]H-1 and Q[6]H-2 ) and [7]helicene ( Q[7]H ) were synthesized via penta-fold Heck and Mallory reaction. Notably, Q[7]H represents the highest reported helicene based on corannulene. X-ray crystallography reveals that Q[6]H-2 adopts a propeller-shaped conformation with a well-preserved corannulene core, while Q[6]H-1 and Q[7]H exhibit quasi-propeller-shaped conformations. Upon heating, conformer Q[6]H-1 undergoes conversion to the thermodynamically more stable conformer Q[6]H-2 , whereas conformer Q[7]H remains unchanged due to larger steric congestion. Racemization of the enantiomer of Q[6]H-1 and conformational conversion were observed simultaneously at elevated temperature, with DFT studies indicating a racemization barrier of 32.06 kcal ⋅ mol −1 . In contrast, the racemization barrier for Q[6]H-2 was calculated to be 45.46 kcal ⋅ mol −1 , indicating exceptional chiral stability. Surprisingly, the bowl inversions of Q[6]H-1 and Q[6]H-2 conformers are somewhat inhibited by the helical blades, whereas this was not observed for other possible conformers of Q[6]H . These results first demonstrated that subtle conformational variations can lead to significant changes in chiral stability and bowl inversions of multiple helicenes. Due to the well-preserved corannulene core, propeller-shaped conformation and electron complementarity, Q[6]H-2 can recognize fullerenes in both solution and solid state, which is a rare instance of co-crystallization assembly between multiple helicenes and fullerenes.}, archive = {J_ANGEW}, author = {Kaixin Zhang and Zuo-Chang Chen and Yin-Fu Wu and Han-Rui Tian and Ling Zhang and Mei-Lin Zhang and Shun-Liu Deng and Qianyan Zhang and Su-Yuan Xie and Lan-Sun Zheng}, doi = {10.1002/anie.202417269}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417269}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Corannulene-based quintuple [6]/[7]Helicenes: Well-preserved bowl core, inhibited bowl inversion and supramolecular assembly with fullerenes}, volume = {64}, year = {2025}, }
• (2025). Interfacial proton precompensation: Suppressing deprotonation-driven lattice collapse for enhanced efficiency and stability in perovskite solar cells. ANGEW, 64(5), e202417262. (www)

  @article{ , abstract = {The chemical property of the buried interface plays a crucial role in improving the performance and stability of perovskite solar cells (PSCs). The SnO 2 /perovskite interface prepared from SnO 2 alkaline hydrogel with high proton affinity triggers directional migration and irreversible reactions of protons, exacerbating the disintegration of perovskite crystal. In this study, we proposed proton precompensation strategy to suppress the deprotonation effect of the buried interface and improve the durability of the devices. By modulating the chemical environment and surface energy state of the buried interface, the domain-limiting and spontaneous compensation of protons in formamidinium (FA + ) under coulomb force were achieved, thereby stabilizing the perovskite crystal structure. The stability of target perovskite films under UV illumination and heating at 85 °C was significantly enhanced. As a result, the devices can retain around 90 % of their initial power conversion efficiency (PCE) after 1000 h of continuous irradiation at the maximum power point (MPP). Moreover, due to the reduction of defect content at the buried interface and the improvement of conductivity and carrier mobility by the precompensation treatment, the interfacial energy loss and non-radiative recombination were substantially diminished. The target PSC devices exhibited much higher PCE of 25.55 % than the control devices (23.03 %).}, archive = {J_ANGEW}, author = {Bingying Xu and Guozhen Liu and Pengfei Wang and Wenzhe Li and Zhehan Ying and Jing Liu and Yantao Shi}, doi = {10.1002/anie.202417262}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacial proton precompensation: Suppressing deprotonation-driven lattice collapse for enhanced efficiency and stability in perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Electrothermal conversion of methane to methanol at room temperature with phosphotungstic acid. ANGEW, 64(5), e202417251. (www)

  @article{ , abstract = {Traditional methods for the aerobic oxidation of methane to methanol frequently require the use of noble metal catalysts or flammable H 2 -O 2 mixtures. While electrochemical methods enhance safety and may avoid the use of noble metals, these processes suffer from low yields due to limited current density and/or low selectivity. Here, we design an electrothermal process to conduct aerobic oxidation of methane to methanol at room temperature using phosphotungstic acid (PTA) as a redox mediator. When electrochemically reduced, PTA activates methane with O 2 to produce methanol selectively. The optimum productivity reaches 29.45 with approximately 20.3 % overall electron yield. Under continuous operation, we achieved 19.90 catalytic activity, over 74.3 % methanol selectivity, and 10 hours durability. This approach leverages reduced PTA to initiate thermal catalysis in solution phase, addressing slow methane oxidation kinetics and preventing overoxidations on electrode surfaces. The current density towards methanol production increased over 40 times compared with direct electrochemical processes. The in situ generated hydroxyl radical, from the reaction of reduced PTA and oxygen, plays an important role in the methane conversion. This study demonstrates reduced polyoxotungstate as a viable platform to integrate thermo- and electrochemical methane oxidation at ambient conditions.}, archive = {J_ANGEW}, author = {Jinquan Chang and Sikai Wang and Max J. Hülsey and Sheng Zhang and Shi Nee Lou and Xinbin Ma and Ning Yan}, doi = {10.1002/anie.202417251}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417251}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrothermal conversion of methane to methanol at room temperature with phosphotungstic acid}, volume = {64}, year = {2025}, }
• (2025). Pre-defined stem-loop structure library for the discovery of L-RNA aptamers that target RNA G-quadruplexes. ANGEW, 64(5), e202417247. (www)

  @article{ , abstract = {L-RNA aptamers have been developed to target G-quadruplexes (G4s) and regulate G4-mediated gene expression. However, the aptamer selection process is laborious and challenging, and aptamer identification is subject to high failure rates. By analyzing the previously reported G4-binding L-RNA aptamers, we found that the stem-loop (SL) structure is favored by G4 binding. Herein, we present a robust and effective G4-SLSELEX-Seq platform specifically for G4 targets by introducing a pre-defined stem-loop structure library during the SELEX process. Using G4-SLSELEX-Seq, we identified an L-RNA aptamer, L-Apt1-12, for the Epstein–Barr nuclear antigen 1 ( EBNA1 ) RNA G4 (rG4) in just three selection rounds. L-Apt1-12 maintained the stem-loop structure initially introduced, and possessed a unique G-triplex motif that is important for the strong binding affinity and specificity to EBNA1 rG4. L-Apt1-12 effectively downregulated endogenous EBNA1 protein expression in human cancer cells and showed selective toxicity towards Epstein–Barr virus (EBV)-positive cancer cells, highlighting its potential for targeted therapy against EBV-associated cancers. Furthermore, we demonstrated the robustness and generality of G4-SLSELEX-Seq by selecting L-RNA aptamers for the amyloid precursor protein ( APP ) rG4 and the hepatitis C virus subtype 1a ( HCV-1a ) rG4, obtaining high-affinity aptamers in three selection rounds. These findings demonstrated G4-SLSELEX-Seq as a robust and efficient platform for the selection of rG4-targeting L-RNA aptamers.}, archive = {J_ANGEW}, author = {Danyang Ji and Bo Wang and Kwok Wai Lo and Chi Man Tsang and Chun Kit Kwok}, doi = {10.1002/anie.202417247}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417247}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pre-defined stem-loop structure library for the discovery of L-RNA aptamers that target RNA G-quadruplexes}, volume = {64}, year = {2025}, }
• (2025). Rebuilding peripheral f, cl, br footprints on acceptors enables binary organic photovoltaic efficiency exceeding 19.7 %. ANGEW, 64(5), e202417244. (www)

  @article{ , abstract = {Given homomorphic fluorine (F), chlorine (Cl) and bromine (Br) atoms are featured with gradually enlarged polarizability/atomic radius but decreased electronegativity, the rational screen of halogen species and locations on small molecular acceptors (SMAs) is quite essential for acquiring desirable molecular packing to boost efficiency of organic solar cells (OSCs). Herein, three isomeric SMAs (CH−F, CH−C and CH−B) are constructed by delicately rebuilding peripheral F, Cl, Br footprints on both central and end units. Such a re-permutation of peripheral halogens could not only maintain the structural symmetry of SMAs to the maximum, but also acquire extra asymmetric benefits of enhanced dipole moment and intramolecular charge transfer, etc. Moreover, central brominating enhances molecular crystallinity of CH−B without introducing undesirable steric hindrance on end groups, thus rendering a better balance between high crystallization and domain size control in PM6:CH−B blend. Further benefitting from the large dielectric constant, small exciton binding energy, optimized molecular packing and great electron transfer integral, CH−B affords the first class binary OSC efficiency of 19.78 %, moreover, the highest efficiency of 18.35 % thus far when increasing active layer thickness to ~300 nm. Our successful screening in rebuilding peripheral halogen footprints provides the valuable insight into further rational design of SMAs for record-breaking OSCs.}, archive = {J_ANGEW}, author = {Xiangjian Cao and Peiran Wang and Xinyuan Jia and Wenkai Zhao and Hongbin Chen and Zheng Xiao and Jiaqi Li and Xingqi Bi and Zhaoyang Yao and Yaxiao Guo and Guankui Long and Chenxi Li and Xiangjian Wan and Yongsheng Chen}, doi = {10.1002/anie.202417244}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417244}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rebuilding peripheral f, cl, br footprints on acceptors enables binary organic photovoltaic efficiency exceeding 19.7 %}, volume = {64}, year = {2025}, }
• (2025). Affecting charges and structures of {Bi6} architectures by 12-electron transition metal fragments. ANGEW, 64(5), e202417234. (www)

  @article{ , abstract = {Molecules based on polyatomic bismuth substructures are currently attracting a lot of attention owing to this heavy and essentially non-toxic element's uncommon chemical and physical properties, which include unprecedented bonding properties. Hexaatomic {Bi 6 } substructures that underly more complex cluster structures were recently reported to adopt different structures or exhibit different structural details as a consequence of the charge of the {Bi 6 } unit. This leads to either crown-shaped cycles for a nominal Bi 6 6− or differently distorted trigonal prisms for compositions close to Bi 6 2− . It was predicted by quantum chemistry that Bi 6 4− should adopt a distinctly distorted boat-like shape, yet a corresponding compound has remained elusive. Here, we report a proof of this assumption by the synthesis of [K(crypt-222)] 2 [Bi 6 {Zn(hmds)} 2 ] ⋅ 1.5THF ( 1 ), comprising a bimetallic [Bi 6 {Zn(hmds)} 2 ] 2− cluster that fulfills the prediction for the geometric and electronic structure of the missing link (crypt-222=4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo-[8.8.8]hexa-cosane, hmds=hexamethyldisilazanid). A detailed quantum chemical study shows how the nature of Lewis-acidic transition metal complexes—in particular, 12-electron fragments—control and fine-tune the resulting {Bi 6 } architectures in accordance with the degree of electron-withdrawal from the polybismuthide core.}, archive = {J_ANGEW}, author = {Andreas Schmidt and Julia Rienmüller and Florian Weigend and Stefanie Dehnen}, doi = {10.1002/anie.202417234}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417234}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Affecting charges and structures of {Bi6} architectures by 12-electron transition metal fragments}, volume = {64}, year = {2025}, }
• (2025). Suppressing energy migration via antiparallel spin alignment in one-dimensional mn2+ halide magnets with high luminescence efficiency. ANGEW, 64(5), e202417218. (www)

  @article{ , abstract = {Photoexcited energy migration is prone to causing luminescence quenching in Mn 2+ luminescent materials, presenting a formidable challenge for optoelectronic applications. Although various strategies and mechanisms have been proposed to mitigate this issue, the role of spin alignment between adjacent Mn 2+ ions has remained largely unexamined. In this study, we have elucidated the influence of spin alignment on energy migration within the one-dimensional Mn 2+ -metal halide compound (CH 3 ) 4 NMnCl 3 (TMMC) through variable-temperature photoluminescence (PL) and magnetic-optical spectroscopy. This investigation was conducted with reference to (CH 6 N 3 ) 2 MnCl 4 (GUA) with isolated [Mn 3 Cl 12 ] 6− trimers and Cd 2+ -doped TMMC. The spin order in TMMC below approximately 55 K is demonstrated by the disorder-order transition observed in the temperature-dependent magnetic susceptibility. This finding is further corroborated by the negligible shift in the temperature- and field-dependent emission peaks, a consequence of magnetic saturation. Our results indicate that the antiparallel spin alignment along the Mn 2+ chain in TMMC effectively suppresses energy migration and multiphonon relaxation, thereby reducing nonradiative transitions and enhancing the photoluminescence quantum yield (PLQY). This research casts new light on the potential for developing high-performance Mn 2+ -doped phosphors for optoelectronic and spin-photonic applications, offering insights into the manipulation of spin and energy dynamics in these materials.}, archive = {J_ANGEW}, author = {Xinglu Zhu and Xiaohui Yan and Enze Kang and Yibo Han and Congling Yin and Shi Ye}, doi = {10.1002/anie.202417218}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417218}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Suppressing energy migration via antiparallel spin alignment in one-dimensional mn2+ halide magnets with high luminescence efficiency}, volume = {64}, year = {2025}, }
• (2025). Stabilization of the compressed planar benzene dianion in inverse-sandwich rare earth metal complexes. ANGEW, 64(5), e202417217. (www)

  @article{ , abstract = {For the first time, the capture of the planar antiaromatic parent benzene dianion in between two trivalent rare earth (RE) metal cations (RE III ), each stabilized by two guanidinate ligands, is reported. The synthesized inverse-sandwich complexes [{(Me 3 Si) 2 NC(N i Pr) 2 } 2 RE] 2 (μ-η 6 : η 6 -C 6 H 6 ), (RE=Y ( 1 ), Dy ( 2 ), and Er ( 3 )) were crystallized from aprotic solvents and feature a remarkably planar parent benzene dianion, previously not encountered for any metal ion prone to low or absent covalency. The −2 charge localization at the benzene ligand was deduced from the results obtained by single-crystal X-ray diffraction analyses, spectroscopy, magnetometry, and Density Functional Theory (DFT) calculations. In the 1 H NMR spectrum of the diamagnetic Y complex 1 , the equivalent proton resonance of the bridging benzene dianion ligand is drastically shifted to higher field in comparison to free benzene. This and the calculated highly positive Nucleus-Independent Chemical Shift (NICS) values are attributed to the antiaromatic character of the benzene dianion ligand. The crucial role of the ancillary guanidinate ligand scaffold in stabilizing the planar benzene dianion conformation was also elucidated by DFT calculations. Remarkably, the planarity of the benzene dianion originates from the stabilization of the π-type orbitals of the d-manifold and compression through its strong electrostatic interaction with the two RE III sites.}, archive = {J_ANGEW}, author = {Francis Delano and Selvan Demir}, doi = {10.1002/anie.202417217}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417217}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilization of the compressed planar benzene dianion in inverse-sandwich rare earth metal complexes}, volume = {64}, year = {2025}, }
• (2025). Direct epitaxial growth of polycrystalline MOF membranes on cu foils for uniform li deposition in long-life anode-free li metal batteries. ANGEW, 64(5), e202417209. (www)

  @article{ , abstract = {Anode-free Li-metal battery (AFLMB) is being developed as the next generation of advanced energy storage devices. However, the low plating and stripping reversibility of Li on Cu foil prevents its widespread application. A promising avenue for further improvement is to enhance the lithophilicity of Cu foils and optimise their surfaces through a metal–organic framework (MOF) functional layer. However, excessive binder usage in the current approaches obscures the active plane of the MOF, severely limiting its performance. In response to this challenge, MOF polycrystalline membrane technology has been integrated into the field of AFLMB in this work. The dense and seamless HKUST-1 polycrystalline membrane was deposited on Cu foil (HKUST-1 M@Cu) via an epitaxial growth strategy. In contrast to traditional MOF functional layers, this binder-free polycrystalline membrane fully exposes lithophilic sites, effectively reducing the nucleation overpotential and optimising the deposition quality of Li. Consequently, the Li plating layer becomes denser, eliminating the effects of dendrites. When coupled with LiFePO 4 cathodes, the battery based on the HKUST-1 membrane exhibits excellent rate performance and cycling stability, achieving a high reversible capacity of approximately 160 mAh g −1 and maintaining a capacity retention of 80.9 % after 1100 cycles.}, archive = {J_ANGEW}, author = {Haiyang Wu and Langyuan Wu and Yang Li and Wendi Dong and Wenyu Ma and Shaopeng Li and Dewei Xiao and Peng Huang and Xiaogang Zhang}, doi = {10.1002/anie.202417209}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417209}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct epitaxial growth of polycrystalline MOF membranes on cu foils for uniform li deposition in long-life anode-free li metal batteries}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of axially chiral allylic nitriles via nickel-catalyzed desymmetric cyanation of biaryl diallylic alcohols. ANGEW, 64(5), e202417208. (www)

  @article{ , abstract = {Axially chiral nitriles are common motifs in organic photoelectric materials, biological compounds, and agrochemicals. Unfortunately, the limited synthetic approaches to axially chiral nitriles have impeded their availability. Herein, we report the first nickel-catalyzed desymmetric allylic cyanation of biaryl allylic alcohols for the synthesis of axially chiral nitrile structures in high yields with excellent enantioselectivities (up to 90 % yield and >99 % ee ). This process enables the synthesis of a diverse range of axially chiral allylic nitriles bearing β , γ -unsaturated alcohol moieties. Leveraging the allylic alcohol and cyano groups as versatile functionalization handles allow for further derivatization of these axially chiral frameworks. Density functional theory (DFT) calculations suggest that both steric and electronic interactions play crucial roles in determining the enantioselectivity of this transformation. Moreover, this mild and facile protocol is also applicable for gram-scale preparation of the chiral nitriles.}, archive = {J_ANGEW}, author = {Can Li and Jian Song and Ting Wang and Xianjie Fang}, doi = {10.1002/anie.202417208}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417208}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of axially chiral allylic nitriles via nickel-catalyzed desymmetric cyanation of biaryl diallylic alcohols}, volume = {64}, year = {2025}, }
• (2025). Near-infrared-emitting helically twisted conjugated frameworks consisting of alternant donor-π-acceptor units and multiple boron atoms. ANGEW, 64(5), e202417200. (www)

  @article{ , abstract = {A novel design strategy to construct bright and narrow near-infrared (NIR) emission materials with suppressed shoulder peaks can significantly enhance their performance in various applications. Herein, we have successfully synthesized a series of helically twisted D-π-A conjugated systems bridged by boron atoms, achieving bright red to near-infrared (NIR) emissions with notably narrow full-width at half-maximum (FWHM) values of 35 nm (0.08 eV) and photoluminescence quantum yields (PLQY) up to 80 %. These compounds display red-shifted emissions up to 753 nm in higher concentrations. Cis / trans configurational isomers of multi-boron-bridged molecule BN3 exhibit similar photophysical properties. The unique combination of boron-induced coordination-enhanced charge transfer (CE-CT) and the helically twisted conjugated framework is pivotal in achieving the red-shifted, narrowband emission. X-ray crystallographic analysis of BN2 and BN3-a reveals that the extension of boron-bridged D-π-A skeletons significantly increases the distortion of the skeleton. Systematic theoretical calculations show how the boron CE-CT mechanism, in conjunction with the helical twist, leads to the narrowing of emission bands while simultaneously red-shifting them into the NIR region. This work could open new avenues for the development of advanced materials with tailored optical properties, particularly in the challenging and highly sought-after NIR spectrum.}, archive = {J_ANGEW}, author = {Jiaqi Dong and Lingjuan Chen and Qingliang Feng and Deng-Tao Yang}, doi = {10.1002/anie.202417200}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417200}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared-emitting helically twisted conjugated frameworks consisting of alternant donor-π-acceptor units and multiple boron atoms}, volume = {64}, year = {2025}, }
• (2025). Selective deuteration and tritiation of pharmaceutically relevant sulfoximines. ANGEW, 64(5), e202417179. (www)

  @article{ , abstract = {Pharmaceutical-aligned research endeavors continue to diversify, including via the installation of new chemical functionality and non-classical bioisosteres within drug design. With this, an equally high demand emerges for the direct installation of isotopic substituents into these scaffolds within drug discovery programmes, as isotopologues are essential for the elucidation of the biological efficacy and metabolic fate of the active pharmaceutical ingredient (API). The sulfoximine functional group has recently become established as a high-value unit in this context; however, general and effective methods for the synthesis of deuterium ( 2 H, D) and tritium ( 3 H, T) labelled analogues have remained elusive. Herein, we disclose the design and development of the first iridium-catalyzed sulfoximine-directed hydrogen isotope exchange (HIE) systems that permit the site-selective integration of a distinguishing atomic label at aromatic C( sp 2 )−H and more challenging C( sp 3 )−H moieties. Moreover, we exemplify the broad applicability of these methods within a spectrum of molecular settings, as well as in the late-stage generation of isotopically-enriched complex bioactive architectures.}, archive = {J_ANGEW}, author = {Blair I. P. Smith and Nathan M. L. Knight and Gary J. Knox and David M. Lindsay and Laura C. Paterson and Jonas Bergare and Charles S. Elmore and Ryan A. Bragg and William J. Kerr}, doi = {10.1002/anie.202417179}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective deuteration and tritiation of pharmaceutically relevant sulfoximines}, volume = {64}, year = {2025}, }
• (2025). Band engineering of mn-P alloy enables HER-suppressed aqueous manganese ion batteries. ANGEW, 64(5), e202417171. (www)

  @article{ , abstract = {Aqueous manganese ion batteries hold potential for stationary storage applications owing to their merits in cost, energy density, and environmental sustainability. However, the formidable challenge is the instability of metallic manganese (Mn) anodes in aqueous electrolytes due to severe hydrogen evolution reaction (HER), which is more serious than the commonly studied Zn metal anodes. Moreover, the mechanism of HER side reactions has remained unclear. Herein, we design a series of Mn−P alloying anodes by precisely regulating their energy band structures to mitigate the HER issue. It is found that the serious HER primarily originates from the spontaneous Mn-H 2 O reaction driven by the excessively high HOMO energy level of Mn, rather than electrocatalytic water splitting. Owing to a reduced HOMO energy level and enhanced electron escape work function, the MnP anode achieves an evidently enhanced cycle durability (over 1000 hours at a high current density of 5 mA cm −2 ). The MnP||AgVO full cell with an N/P ratio of 4 exhibits better rate capability and extended cycle life (7000 cycles) with minimal capacity degradation than the cell using metallic Mn anode (less than 100 cycles). This study provides a practical approach for developing highly durable aqueous Mn ion batteries}, archive = {J_ANGEW}, author = {Wenqiang Lu and Tianfang Zheng and Xinyuan Zhang and Tianmin He and Yuxin Sun and Shuyang Li and Buyuan Guan and Dong Zhang and Zhixuan Wei and Heng Jiang and Hong Jin Fan and Fei Du}, doi = {10.1002/anie.202417171}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417171}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Band engineering of mn-P alloy enables HER-suppressed aqueous manganese ion batteries}, volume = {64}, year = {2025}, }
• (2025). Spherical DNA nanomotors enable ultrasensitive detection of active enzymes in extracellular vesicles for cancer diagnosis. ANGEW, 64(5), e202417165. (www)

  @article{ , abstract = {Enzymes encapsulated in extracellular vesicles (EVs) hold promise as biomarkers for early cancer diagnosis. However, precise measurement of their catalytic activities within EVs remains a notable challenge. Here, we report an enzymatically triggered spherical DNA nanomotor (EDM) that enables one-pot, cascaded, and highly sensitive analysis of the activity of EV-associated or free apurinic/apyrimidinic endonuclease 1 (APE1, a key enzyme in base excision repair) across various biological samples. The EDM capitalizes on APE1-triggered activation of DNAzyme (Dz) and its autonomous cleavage of substrates to achieve nonlinear signal amplification. Using EDM, we demonstrate a strong correlation between APE1 activity in EVs and that of their parental cancer cells. Additionally, EV APE1 mirrors the fluctuation of cellular APE1 activity in response to chemotherapy-induced DNA damage. In a pilot clinical study ( n =63), the EDM-based assay reveals that more than 80 % of active APE1 in serum samples is EV-encapsulated. Notably, EV APE1 can differentiate early prostate cancer (PCa) patients from healthy donors (HDs) with an overall accuracy of 92 %, outperforming free APE1 in sera. We anticipate that EDM will become a versatile tool for quantifying EV-associated enzymes.}, archive = {J_ANGEW}, author = {Jinqi Deng and Shuai Zhao and Kai Xie and Chao Liu and Chuangui Sheng and Junhong Li and Bo Dai and Shuo Wan and Lele Li and Jiashu Sun}, doi = {10.1002/anie.202417165}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417165}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spherical DNA nanomotors enable ultrasensitive detection of active enzymes in extracellular vesicles for cancer diagnosis}, volume = {64}, year = {2025}, }
• (2025). Pore structure modulation in kirigamic zeolitic imidazolate framework. ANGEW, 64(5), e202417137. (www)

  @article{ , abstract = {Paper crafts, such as origami and kirigami, have become an interdisciplinary research theme transportable from art to science, and further to engineering. Kirigami-inspired architectural design strategies allow the establishment of three-dimensional (3D) mechanical linkages with unprecedented mechanical properties. Herein, we report a crystalline zeolitic imidazolate framework (ZIF), displaying folding mechanics based on a kirigami tessellation, originated from the double-corrugation surface (DCS) pattern. Pressure- and guest-induced responses demonstrate the kirigami mechanism of the ZIF, wherein imidazolate linkers act as hinges, controlling pore dimensionality, resembling the check valve-adapted mechanical manifold. This discovery of the kirigami tessellation inside a flexible ZIF reveals foldable mechanics at the molecular level.}, archive = {J_ANGEW}, author = {Joohan Nam and Eunji Jin and Leila Abylgazina and Jürgen Getzschmann and Wen-Long Xue and Hong Kyu Lee and Hyunchul Oh and Hoi Ri Moon and Sebastian Henke and Andreas Schneemann and Wonyoung Choe}, doi = {10.1002/anie.202417137}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417137}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pore structure modulation in kirigamic zeolitic imidazolate framework}, volume = {64}, year = {2025}, }
• (2025). One-step maleimide-based dual functionalization of protein N-termini. ANGEW, 64(5), e202417134. (www)

  @article{ , abstract = {Maleimide derivatives are privileged reagents for chemically modifying proteins through the Michael addition reaction with cysteine due to their selectivity, operational simplicity, and commercial availability. However, since accessible free cysteine is rarely found in natural proteins, it is highly desirable to find alternative targets to enable direct bioconjugation of proteins with maleimides. In this study, we have developed an operationally simple and straightforward method for the N-terminal modification of proteins without the need for mutagenesis via a copper(II)-mediated [3+2] cycloaddition reaction with maleimides and 2-pyridinecarboxaldehyde (2-PCA) derivatives under non-denaturing conditions at pH 6 and 37 °C in aqueous media. Our method utilizes commercially available maleimides to attach diverse functionalities to various N-terminal amino acids. We demonstrate the preparation of a ternary protein complex cross-linked at the N-termini and dually modified trastuzumab equipped with monomethyl auristatin E (MMAE), a cytotoxic agent, and a Cy5 fluorophore (MMAE-Cy5-trastuzumab). MMAE-Cy5-trastuzumab retained human epidermal growth factor receptor 2 (HER2) recognition activity and exerted cytotoxicity against HER2-positive cells. Furthermore, MMAE-Cy5-trastuzumab allowed successful visualization of HER2-positive cancer cells in mouse tumors. This straightforward method will expand the accessibility of protein conjugates with well-defined structures in a wide range of research fields.}, archive = {J_ANGEW}, author = {Kengo Hanaya and Kazuaki Taguchi and Yuki Wada and Masaki Kawano}, doi = {10.1002/anie.202417134}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417134}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-step maleimide-based dual functionalization of protein N-termini}, volume = {64}, year = {2025}, }
• (2025). Cu−Bi bimetallic catalysts derived from Metal–Organic framework arrays on copper foam for efficient glycine electrosynthesis. ANGEW, 64(5), e202417130. (www)

  @article{ , abstract = {Glycine as one of the most abundant amino acids in human proteins, with extensive applications in both life and industry, is conventionally synthesized through complex procedures or toxic feedstocks. In this study, we present a facile and benign electrochemical pathway for synthesis of glycine through reductive coupling of glyoxylic acid and nitrate over a copper-bismuth bimetal catalyst derived from a metal–organic framework (MOF) array on copper foam (Cu/Bi−C@CF). Remarkably, Cu/Bi−C@CF achieves a fantastic selectivity of 89 %, corresponding a high Faraday efficiency of 65.9 %. From control experiments, the introduction of Bi caused the binding energy of Cu shift to a lower state, which leads to a high selectivity towards the formation of key intermediate hydroxylamine rather than ammonia product, facilitating the formation of oxime and providing additional sites for subsequent hydrogenation reaction on the way to glycine. Moreover, the derivation of MOF arrays ensures the effective dispersion of Bi and enhances the stability of Cu/Bi−C@CF. This innovative approach not only presents sustainable pathways for the production of value-added organonitrogen compounds utilizing readily available carbon and nitrogen sources, but also provides novel insights into the design of multistage structural catalysts for sequential reactions.}, archive = {J_ANGEW}, author = {Peisen Liao and Binning Zeng and Suisheng Li and Yuhao Zhang and Runan Xiang and Jiawei Kang and Qinghua Liu and Guangqin Li}, doi = {10.1002/anie.202417130}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417130}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cu−Bi bimetallic catalysts derived from Metal–Organic framework arrays on copper foam for efficient glycine electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Synchronous modulation of H-bond interaction and steric hindrance via bio-molecular additive screening in zn batteries. ANGEW, 64(5), e202417125. (www)

  @article{ , abstract = {In addressing challenges such as side reaction and dendrite formation, electrolyte modification with bio-molecule sugar species has emerged as a promising avenue for Zn anode stabilization. Nevertheless, considering the structural variability of sugar, a comprehensive screening strategy is meaningful yet remains elusive. Herein, we report the usage of sugar additives as a representative of bio-molecules to develop a screening descriptor based on the modulation of the hydrogen bond component and electron transfer kinetics. It is found that xylo-oligosaccharide (Xos) with the highest H-bond acceptor ratio enables efficient water binding, affording stable Zn/electrolyte interphase to alleviate hydrogen evolution. Meanwhile, sluggish reduction originated from the steric hindrance of Xos contributes to optimized Zn deposition. With such a selected additive in hand, the Zn||ZnVO full cells demonstrate durable operation. This study is anticipated to provide a rational guidance in sugar additive selection for aqueous Zn batteries.}, archive = {J_ANGEW}, author = {Wenyi Guo and Liang Xu and Yiwen Su and Liming Zhao and Yifan Ding and Yuhan Zou and Guangping Zheng and Tao Cheng and Jingyu Sun}, doi = {10.1002/anie.202417125}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417125}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synchronous modulation of H-bond interaction and steric hindrance via bio-molecular additive screening in zn batteries}, volume = {64}, year = {2025}, }
• (2025). Phenanthridine-based covalent organic frameworks for boosting overall solar H2O2 production. ANGEW, 64(5), e202417115. (www)

  @article{ , abstract = {Solar-driven H 2 O 2 production via the oxygen reduction reaction (ORR) and water oxidation reaction (WOR) dual channels is green and sustainable but severely restricted by the sluggish reaction kinetics. Constructing intriguing photocatalysts with effective active centers is a shortcut to breaking the kinetic bottleneck with great significance. Herein, we synthesize two novel neutral phenanthridine-based covalent organic frameworks (PD-COF1 and PD-COF2) for photosynthesizing H 2 O 2 . Compared to the no phenanthridine counterpart (AN-COF), the H 2 O 2 photosynthetic activities of PD-COF1 and PD-COF2 are markedly boosted. In air and pure water without sacrificial agents, under Xe lamp and natural sunlight, the H 2 O 2 photogeneration rate of PD-COF2 is 6103 and 3646 μmol g −1 h −1 , respectively. Further experimental and theoretical inspections demonstrate that introducing phenanthridine units into COFs smoothly modulates the charge carrier dynamics and thermodynamically favors the generation of crucial OOH* and OH* intermediates in the ORR and WOR paths, respectively. Additionally, this is the first time the neutral phenanthridine moiety serves as the photooxidation unit for 2e − WOR towards H 2 O 2 photoproduction. The current work sheds light on exploring novel catalytic centers for high-performance H 2 O 2 evolution.}, archive = {J_ANGEW}, author = {Jie-Yu Yue and Jing-Xian Luo and Zi-Xian Pan and Qing Xu and Peng Yang and Bo Tang}, doi = {10.1002/anie.202417115}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417115}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Phenanthridine-based covalent organic frameworks for boosting overall solar H2O2 production}, volume = {64}, year = {2025}, }
• (2025). Enhancing molecular-level biological monitoring with a smart self-assembling 19F-labeled probe. ANGEW, 64(5), e202417112. (www)

  @article{ , abstract = {Real-time monitoring of molecular transformations is crucial for advancements in biotechnology. In this study, we introduce a novel self-assembling 19 F-labeled nuclear magnetic resonance (NMR) probe that disassembles upon interaction with various nucleotides. This interaction not only activates the 19 F signals but also produces distinct signatures for each specific component, thereby enabling precise identification and quantification of molecules in evolving samples. We demonstrate the capability of this probe for real-time monitoring of adenosine triphosphate (ATP) hydrolysis and screening potential enzyme inhibitors. These applications highlight the probe's significant potential in enzyme analysis, drug development, and disease diagnostics.}, archive = {J_ANGEW}, author = {Zhenchuang Xu and Chenyang Wang and Shengyuan He and Jian Wu and Yanchuan Zhao}, doi = {10.1002/anie.202417112}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417112}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing molecular-level biological monitoring with a smart self-assembling 19F-labeled probe}, volume = {64}, year = {2025}, }
• (2025). Fuel-driven π-conjugated superstructures to form transient conductive hydrogels. ANGEW, 64(5), e202417109. (www)

  @article{ , abstract = {Despite advances in creating dissipative materials with transient properties, such as hydrogels and active droplets, their application remains confined to temporal changes in structural properties. Developing out-of-equilibrium materials whose electronic functions are parameterized by a chemical reaction cycle is challenging. Yet, this class of materials is required to construct biomimetic materials. In contrast to traditional chemical reaction cycles that exploit molecularly dissolved building blocks at thermodynamic equilibrium, we show that fiber structures derived from reactive naphthalene diimide (NDI) building blocks can be used as resting states to form far-from-equilibrium conductive hydrogels after the addition of chemical fuels. Upon fueling the NDI-derived fibers, a dual-component activation and deactivation pathway is deduced by kinetic analysis and is absent when using a molecularly dissolved resting state. Investigating the solid-state morphologies of the structures formed throughout the fuel-driven reaction cycle using cryo-EM reveals that the resting thermodynamic fibers evolve to transient thicker fibrils and layered superstructures. We show that the transient redox-active hydrogels exhibit a nearly threefold increase in electrical conductivity upon fuel consumption before reverting to their original value over hours. These far-from-equilibrium materials are potential candidates in applications such as programmable biorobotics and chemical computing.}, archive = {J_ANGEW}, author = {Ifigeneia Tsironi and Jarek A. Maleszka and Brigitte A. K. Kriebisch and Robert S. Wilson-Kovacs and Orlando Acevedo and Shamus L. O'Leary and John Watt and Job Boekhoven and Jean-Hubert Olivier}, doi = {10.1002/anie.202417109}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417109}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fuel-driven π-conjugated superstructures to form transient conductive hydrogels}, volume = {64}, year = {2025}, }
• (2025). Enhancing microdomain consistency in polymer electrolytes towards sustainable lithium batteries. ANGEW, 64(5), e202417105. (www)

  @article{ , abstract = {Polymer electrolytes incorporated with fillers possess immense potential for constructing the fast and selective Li + conduction. However, the inhomogeneous distribution of the fillers usually deteriorates the microdomain consistency of the electrolytes, resulting in uneven Li + flux, and unstable electrode-electrolyte interfaces. Herein, we formulate a solution-process chemistry to in situ construct gel polymer electrolytes (GPEs) with well-dispersed metal–organic frameworks (MOFs), leading to a uniform microdomain structure. Through the integration of X-ray computed tomography analyses and theoretical simulations, our research identifies that the improvement of microdomain consistency in GPEs is beneficial for enhancing its mechanical strength, homogenizing ionic/electronic field distribution and upgrading the interface stability with the elctrodes. Moreover, consistently spread MOFs bind effectively with Lewis-base anions of Li salts, enhancing Li + kinetics. Owing to these advantages, the developed GPEs achieve a high conductivity of 1.51 mS cm −1 and a Li + transference number of 0.66, resulting in exceptional cyclability of lithium metal electrodes (over 1800 hours). Additionally, the solid-state NCM811//Li pouch batteries exhibit an impressive capacity retention of 94.2 % over 200 cycles with an N/P ratio of 1.69. This study emphasizes the significant impact of microdomain structural chemistry on the advancement of solid-state batteries.}, archive = {J_ANGEW}, author = {Yang Feng and Yanpeng Fan and Lingfei Zhao and Jiangtao Yu and Yaqi Liao and Tongrui Zhang and Ruochen Zhang and Haitao Zhu and Xingwei Sun and Zhe Hu and Kai Zhang and Jun Chen}, doi = {10.1002/anie.202417105}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417105}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing microdomain consistency in polymer electrolytes towards sustainable lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Engineered polymeric carbon nitride for photocatalytic diverse functionalization of electronic-rich alkenes. ANGEW, 64(5), e202417099. (www)

  @article{ , abstract = {Engineered polymeric carbon nitride represents a promising class of metal-free semiconductor photocatalysts for organic synthesis. Herein, we utilized engineered polymeric carbon nitride nanosheets, which exhibit an increased specific surface area and band gap due to enhanced quantum confinement from vacancy enrichment. These nanosheets serve as a heterogeneous organic semiconductor photocatalyst to facilitate diverse functionalizations of electron-rich alkenes, including arylsulfonylation, aminodifluoroalkylation, and oxytrifluoromethylation. This catalytic system operates under mild conditions, offering excellent functional group compatibility and high yields. Additionally, the catalyst demonstrates outstanding recyclability and efficiency in flow reactors, highlighting its significant potential for industrial applications.}, archive = {J_ANGEW}, author = {Youqing Yang and Jiwei Shi and Chenguang Liu and Qiong Liu and Jian Yang and Xiaogang Tong and Jiong Lu and Jie Wu}, doi = {10.1002/anie.202417099}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417099}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineered polymeric carbon nitride for photocatalytic diverse functionalization of electronic-rich alkenes}, volume = {64}, year = {2025}, }
• (2025). Atomically asymmetrical Ir−O–Co sites enable efficient chloride-mediated ethylene electrooxidation in neutral seawater. ANGEW, 64(5), e202417092. (www)

  @article{ , abstract = {The chloride-mediated ethylene oxidation reaction (EOR) of ethylene chlorohydrin (ECH) via electrocatalysis is practically attractive because of its sustainability and mild reaction conditions. However, the chlorine oxidation reaction (COR), which is essential for the above process, is commonly catalyzed by dimensionally stable anodes (DSAs) with high contents of precious Ru and/or Ir. The development of highly efficient COR electrocatalysts composed of nonprecious metals or decreased amounts of precious metals is highly desirable. Herein, we report a modified Co 3 O 4 with a single-atom Ir substitution (Ir 1 /Co 3 O 4 ) as a highly efficient COR electrocatalyst for chloride-mediated EOR to ECH in neutral seawater. Ir 1 /Co 3 O 4 achieves a Faradaic efficiency (FE) of up to 94.8 % for ECH generation and remarkable stability. Combining experimental results and density functional theory (DFT) calculations, the unique atomically asymmetrical Ir−O−Co configuration with a strong electron coupling effect in Ir1/Co 3 O 4 can accelerate electron transfer to increase the reaction kinetics and maintain the structural stability of Co 3 O 4 during COR. Moreover, a coupling reaction system integrating the anodic chloride-mediated and cathodic H 2 O 2 -mediated EOR show a total FE of ~170 % for paired electrosynthesis of ECH and ethylene glycol (EG) using ethylene as the raw material. The technoeconomic analysis highlights the promising application prospects of this system.}, archive = {J_ANGEW}, author = {Linke Cai and Yao Liu and Ying Gao and Bo-Hang Zhao and Jiacheng Guan and Xiao Liu and Bin Zhang and Yi Huang}, doi = {10.1002/anie.202417092}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomically asymmetrical Ir−O–Co sites enable efficient chloride-mediated ethylene electrooxidation in neutral seawater}, volume = {64}, year = {2025}, }
• (2025). Triflic acid-catalyzed dehydrative amination of 2-arylethanols with weak N-nucleophiles in hexafluoroisopropanol. ANGEW, 64(5), e202417089. (www)

  @article{ , abstract = {The catalytic deoxyamination of readily available 2-arylethanols offers an appealing, simple, and straightforward means of accessing β-(hetero)arylethylamines of biological interest. Yet, it currently represents a great challenge to synthetic chemistry. In most cases, the alcohol has to be either pre-activated in situ or converted into a reactive carbonyl intermediate, limiting the substrate scope for some methods. Examples of direct dehydrative amination of 2-arylethanols are thus still scarce. Here, we describe a catalytic protocol based on the synergy of triflic acid and hexafluoroisopropanol, which enables the direct and stereospecific amination of a broad array of 2-arylethanols, and does not require any pre-activation of the alcohol. This approach yields high value-added products incorporating sulfonamide, amide, urea, and aniline functionalities. In addition, this approach was applied to the sulfidation of 2-arylethanols. Mechanistic experiments and DFT computations indicate the formation of phenonium ions as key intermediates in the reaction.}, archive = {J_ANGEW}, author = {Max Van Hoof and Robert J. Mayer and Joseph Moran and David Lebœuf}, doi = {10.1002/anie.202417089}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417089}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triflic acid-catalyzed dehydrative amination of 2-arylethanols with weak N-nucleophiles in hexafluoroisopropanol}, volume = {64}, year = {2025}, }
• (2025). A chiral COFs membrane for enantioselective amino acid separation. ANGEW, 64(5), e202417088. (www)

  @article{ , abstract = {Incorporating chiral molecules in the covalent organic frameworks (COFs) with uniformly ordered pores results in chiral COFs, which have been highly promising candidates for enantioseparation. Herein, a homochiral COF nanochannel membrane is reported by introducing chiral centers (L-phenylalanine methyl ester) into one of the organic ligands for the enantioseparation of chiral amino acids. The separation results show that the D-isomer is preferentially transported through the porous membrane channel. This composite membrane exhibits excellent selectivity for racemic phenylalanine with the highest enantiomeric excess value of up to 99.4 %. The adsorption and molecular modeling studies substantiate the experiment results by showing higher bonding affinity towards D-isomer over L-isomer. The excellent enantioselective gating performance unveils the porous COF skeleton with chiral selectors and the size-matching synergy for stereoselective interactions with chiral isomers.}, archive = {J_ANGEW}, author = {Narmadha Manoranjan and Wangxi Fang and Yuzhang Zhu and Jian Jin}, doi = {10.1002/anie.202417088}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417088}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A chiral COFs membrane for enantioselective amino acid separation}, volume = {64}, year = {2025}, }
• (2025). In situ stimulus response study on the Acetylene/Ethylene purification process in MOFs. ANGEW, 64(5), e202417072. (www)

  @article{ , abstract = {Efficient removal of acetylene (C 2 H 2 ) impurities from polymer-grade ethylene (C 2 H 4 ) in a simple, clean manner remains a challenging goal in industry. The use of porous materials such as metal–organic frameworks (MOFs) is promising for this aim but the acquisition of high purification performance is still hindered by few knowledge on the purification process because the previous conclusions were derived basically from the non-breakthrough tests or ignored the influence of structural difference (crystal structure, morphology, or defect). Here we propose an unprecedented in situ stimulus response strategy to minimize the influence of structural difference, obtain the gas-loading crystal structures of the same MOF before and after light or heat stimulation, directly observe the evolution of pore charge distribution and pore⋅⋅⋅gas interactions under light/heat induction, and finally summarizes the favorable structure for highly efficient purification of C 2 H 4 . This study opens a new route to understand the relationship between the structure and separation performance for porous materials.}, archive = {J_ANGEW}, author = {Li-Zhen Cai and Xu-Ying Yu and Ming-Sheng Wang and Da-Qiang Yuan and Wen-Fa Chen and Ming-Yan Wu and Guo-Cong Guo}, doi = {10.1002/anie.202417072}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417072}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ stimulus response study on the Acetylene/Ethylene purification process in MOFs}, volume = {64}, year = {2025}, }
• (2025). Highly selective on-surface dehydrogenative aromatization of n-hexyl to phenyl substituents. ANGEW, 64(5), e202417070. (www)

  @article{ , abstract = {Dehydrogenative aromatization of alkyl substituents represents a powerful approach to aryl-substituted functional molecules. However, the inertness of alkyl groups and the need for harsh reaction conditions accompanied by low product selectivity hamper its widespread applications. Here, we demonstrate the highly selective on-surface thermal aromatization of n -hexyl substituents on polycyclic aromatic hydrocarbons (PAHs) to their phenyl-substituted analogues under mild conditions. After depositing two representative precursor molecules, n -hexyl-substituted hexaphenylbenzene (HPB-Hex) and bianthryl octacarboxylic tetraimide (BATI-Hex), onto a pre-heated Au(111) substrate, dehydroaromatization of the peripheral n -hexyl groups into phenyl rings occurs, following the planarization of hexaphenylbenzene and bianthryl core. This process involves sequential intramolecular C−C bond rotations, dehydrogenation, and cyclodehydrogenation reactions, yielding phenyl-substituted hexabenzocoronene (HBC-Ph) and bisanthene octacarboxylic tetraimides (BSTI-Ph). The reaction sequences were monitored using scanning tunneling microscopy (STM) and bond-resolved non-contact atomic force microscopy (nc-AFM), offering structural proof of both intermediates and final products. These experimental techniques were complemented by density functional theory (DFT) simulations, which facilitated the detection of crucial steps in the conversion of n -hexyl to phenyl groups. Moreover, the effect of alkyl aromatization on the electronic properties of the newly formed aromatic hydrocarbons was elucidated using scanning tunneling spectroscopy (STS).}, archive = {J_ANGEW}, author = {Lina Wang and Ye Liu and Miao Xie and Yi Han and Liangliang Chen and Renjie Xue and Hailong Li and Xisha Zhang and Deqing Zhang and Qigang Zhong and Qiang Chen and Haiming Zhang and Klaus Müllen and Lifeng Chi}, doi = {10.1002/anie.202417070}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly selective on-surface dehydrogenative aromatization of n-hexyl to phenyl substituents}, volume = {64}, year = {2025}, }
• (2025). Effective proton conduction in quasi-solid zinc-manganese batteries via constructing highly connected transfer pathways. ANGEW, 64(5), e202417049. (www)

  @article{ , abstract = {Elusive ion behaviors in aqueous electrolyte remain a challenge to break through the practicality of aqueous zinc-manganese batteries (AZMBs), a promising candidate for safe grid-scale energy storage systems. The proposed electrolyte strategies for this issue most ignore the prominent role of proton conduction, which greatly affects the operation stability of AZMBs. Here we report a water-poor quasi-solid electrolyte with efficient proton transfer pathways based on the large-space interlayer of montmorillonite and strong-hydration Pr 3+ additive in AZMBs. Proton conduction is deeply understood in this quasi-solid electrolyte. Pr 3+ additive not only dominates the proton conduction kinetics, but also regulates the reversible manganese interfacial deposition. As a result, the Cu@Zn||α-MnO 2 cell could achieve a high specific capacity of 433 mAh g −1 at 0.4 mA cm −2 and an excellent stability up to 800 cycles with a capacity retention of 92.2 % at 0.8 mA cm −2 in such water-poor quasi-solid electrolyte for the first time. Ah-scale pouch cell with mass loading of 15.19 mg cm −2 sustains 100 cycles after initial activation, which is much better than its counterparts. Our work provides a new path for the development of zinc metal batteries with good sustainability and practicality.}, archive = {J_ANGEW}, author = {Zhexuan Liu and Mulan Qin and Biao Fu and Mingzhu Li and Shuquan Liang and Guozhao Fang}, doi = {10.1002/anie.202417049}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417049}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Effective proton conduction in quasi-solid zinc-manganese batteries via constructing highly connected transfer pathways}, volume = {64}, year = {2025}, }
• (2025). Natural polyphenol-reinforced ion-selective separators for high-performance lithium-sulfur batteries with high sulfur loading and lean electrolyte. ANGEW, 64(5), e202417031. (www)

  @article{ , abstract = {Ion-selective separators are promising to inhibit soluble intermediates shuttle in practical lithium-sulfur (Li−S) batteries. However, designing and fabricating such high-performance ion-selective separators using cost-effective, eco-friendly, and versatile methods remains a formidable challenge. Here we present ion-selective separators fabricated via the spontaneous deposition of green tea-derived polyphenols onto a polypropylene separator, aimed at enhancing the stability of Li−S batteries. The resulting natural polyphenol-reinforced ion-selective (NPRIS24) separators exhibit rapid Li ion transport and high soluble intermediates inhibition capability with an ultralow shuttle rate of 0.67 % for Li 2 S 4 , 0.19 % for Li 2 S 6 and 0.10 % for Li 2 S 8 . This superior ion-selectivity arises from the high electronegativity and strong lithiophilic nature of the phenolic compounds. Consequently, we have achieved high-performance Li−S batteries that are steadily cyclable under the challenging conditions of an S loading of 5.7 mg cm −2 , an electrolyte-to-S ratio of 5.1 μL mg −1 , and a 50 μm Li foil anode. Furthermore, the NPRIS24 separator enhances the performance of other Li metal batteries utilizing commercial LiFePO 4 (5.3 mg cm −2 ) and LiNi 0.5 Co 0.2 Mn 0.3 O 2 (9.9 mg cm −2 ) cathodes. This work underscores the potential of utilizing natural polyphenols for the design of advanced ion-selective separators in energy storage systems.}, archive = {J_ANGEW}, author = {Yanfei Yang and Wankai Wang and Junping Zhang}, doi = {10.1002/anie.202417031}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Natural polyphenol-reinforced ion-selective separators for high-performance lithium-sulfur batteries with high sulfur loading and lean electrolyte}, volume = {64}, year = {2025}, }
• (2025). Bifunctional Metal–Organic framework synergistically enhances radiotherapy and activates STING for potent cancer radio-immunotherapy. ANGEW, 64(5), e202417027. (www)

  @article{ , abstract = {The activation of the stimulator of interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic STING agonists like 4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid (MSA-2) exhibit suboptimal pharmacokinetics and fail to sustain STING activation in tumors for effective antitumor responses. Here, we report the design of MOF/MSA-2, a bifunctional MSA-2 conjugated nanoscale metal–organic framework (MOF) based on Hf 6 secondary building units (SBUs) and hexakis(4′-carboxy[1,1′-biphenyl]-4-yl)benzene bridging ligands, for potent cancer radio-immunotherapy. By leveraging the high-Z properties of the Hf 6 SBUs, the MOF enhances the therapeutic effect of X-ray radiation and elicits potent immune stimulation in the tumor microenvironment. MOF/MSA-2 further enhances radiotherapeutic effects of X-rays by enabling sustained STING activation and promoting the infiltration and activation of immune cells in the tumors. MOF/MSA-2 plus low-dose X-ray irradiation elicits strong STING activation and potent tumor regression, and when combined with an immune checkpoint inhibitor, effectively suppresses both primary and distant tumors through systemic immune activation.}, archive = {J_ANGEW}, author = {Chaoyu Wang and Jinhong Li and Xiaomin Jiang and Xin Ma and Wenyao Zhen and Langston Tillman and Ralph R. Weichselbaum and Wenbin Lin}, doi = {10.1002/anie.202417027}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417027}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bifunctional Metal–Organic framework synergistically enhances radiotherapy and activates STING for potent cancer radio-immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Nanoparticle transport in proximal tubules with rhabdomyolysis-induced necrosis. ANGEW, 64(5), e202417024. (www)

  @article{ , abstract = {Renal-clearable engineered nanoparticles are being explored for their potential to deliver therapeutic agents for kidney disease treatment. A fundamental understanding of how these nanoparticles accumulate in diseased kidneys at the cellular level is essential to enhance their effectiveness and minimize side effects on adjacent healthy tissues. Herein, we report that the accumulation of glutathione-coated, near-infrared emitting gold nanoparticles (GS-AuNPs) correlates strongly with the necrotic stages of injured proximal tubular cells. Using a rhabdomyolysis-induced acute kidney injury (AKI) mouse model, we observed that GS-AuNPs were significantly accumulated in the extracellular lumen of proximal tubular epithelial cells (PTECs) at advanced necrotic stage, where cellular debris and released intracellular contents impeded their clearance. In contrast, during early necrosis, GS-AuNPs were still cleared through the unobstructed lumen. Additionally, intracellular uptake of GS-AuNPs was significantly reduced across all necrotic stages. These findings underscore the need for new strategies to design nanoparticles that can effectively target and be taken up by the diseased tubular cells before extensive necrosis occurs; so that nanoparticle-mediated drug delivery for kidney disease treatment can be achieved with desired efficacy and precision.}, archive = {J_ANGEW}, author = {Yingyu Huang and Jie Zheng and Mengxiao Yu}, doi = {10.1002/anie.202417024}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417024}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanoparticle transport in proximal tubules with rhabdomyolysis-induced necrosis}, volume = {64}, year = {2025}, }
• (2025). Excitation-dependent anti-thermal quenching in zero-dimensional manganese bromides for photoluminescence and X-ray scintillation. ANGEW, 64(5), e202417018. (www)

  @article{ , abstract = {One of the most significant challenges of luminescent materials is the thermal quenching (TQ) at high temperature. Understanding the correlation between crystal structure variation and photoluminescence (PL) quenching is significant to achieve anti-thermal quenching (anti-TQ) phosphors. Herein, we unveil a universal principle governing switchable TQ and anti-TQ behaviors in zero-dimensional (0D) organic–inorganic hybrid manganese bromides. We observed an abnormal anti-TQ phenomenon when phosphor is excited in the valley of PL excitation (PLE) spectrum (indirect excitation) while TQ phenomenon is observed when excited in the peak and shoulder positions of PLE. Our findings demonstrate that PL intensity is influenced by two variable parameters: the effective Mn-ligand distance and the shortest Mn−Mn distance. These excitation-dependent TQ and anti-TQ behaviors originate from the relative changes in these distances, which modulate the competition between radiative and nonradiative recombination rates, as evidenced at the molecular level by molecular dynamics simulation. X-ray activated radioluminescence (RL) also exhibits anti-TQ behavior, which is analogous to the indirect excitation of PL evolution when excited at PLE valley. These insights bridge the gap between PL and RL properties in 0D manganese halides and offer potential avenues for developing advanced anti-TQ phosphors, efficient LEDs, and high-performance scintillators.}, archive = {J_ANGEW}, author = {Ye Wu and Yiyuan Zhu and Ashour A. Ahmed and Muhammad Imran and Shuangchen Qiu and Yang Liu and Xudong Hu and Yasser Hassan and Zhiguo Sun and Renren Deng and Xiaoming Li}, doi = {10.1002/anie.202417018}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202417018}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Excitation-dependent anti-thermal quenching in zero-dimensional manganese bromides for photoluminescence and X-ray scintillation}, volume = {64}, year = {2025}, }
• (2025). Modulating the band structure of two-dimensional black phosphorus via electronic effects of organic functional groups for enhanced hydrogen production activity. ANGEW, 64(5), e202416992. (www)

  @article{ , abstract = {Electronic effects of organic functional groups play a fundamental role in determining the rate and/or direction of organic chemical reactions. The implementation of this concept in selective organic catalysis is achieved by tuning the electronic effects of organic functional groups to alter the corresponding reactivity. However, this approach has hardly been applied to modulate the band structure of inorganic materials. Here, we show that modulating the electronic band structure of two-dimensional black phosphorus (BP) is possible via the electronic effects of organic functional groups covalently modified on its surface. Organic functional group can either donate or withdraw charge density from BP surface, which will alter the bonding/anti-binding orbitals occupancy and thus shift the band-edge positions of functionalized BP downward/upward. Therefore, the valence-band maxima and the conduction-band minima of functionalized BP can be continuously tuned by changing the binding group with different Hammett parameters. Finally, unexpectedly high hydrogen evolution reaction rates under visible light are achieved using functionalized BP heterojunctions as photocatalysts. This work underscores the significant role of electronic effects in chemically controlling BP's band structure, offering greater flexibility and affordability beyond physical method limits.}, archive = {J_ANGEW}, author = {Xuefeng Leng and Kaicheng Yang and Liping Sun and Jian Weng and Jun Xu}, doi = {10.1002/anie.202416992}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416992}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating the band structure of two-dimensional black phosphorus via electronic effects of organic functional groups for enhanced hydrogen production activity}, volume = {64}, year = {2025}, }
• (2025). Performance and stability of corundum-type In2O3 catalyst for carbon dioxide hydrogenation to methanol. ANGEW, 64(5), e202416990. (www)

  @article{ , abstract = {Carbon dioxide hydrogenation to methanol is a key chemical reaction to store energy in chemical bonds, using carbon dioxide as an energy sink. Indium oxide is amongst the most promising candidates for replacing the copper and zinc oxide catalyst, which is industrially applied for syngas mixtures but less idoneous for educts with carbon dioxide due to instability reasons. The polymorph of indium oxide and the operating conditions remain to be optimized for optimal and stable performance. Indium oxide catalysts containing different rhombohedral and cubic phase ratios were synthesized using a solvothermal method and evaluated in an ideally mixed gas phase reactor. The pure rhombohedral catalyst shows the best performance in terms of yield to methanol, selectivity, and stability. The phase stability was assessed using synchrotron in situ XRD and Rietveld refinement, shedding light on the stability of the different phases at extended operating conditions. Depending on the flow rate, temperature, and hydrogen partial pressure, a rhombohedral to cubic transition occurs, ultimately yielding inactive metallic indium. If present, cubic In 2 O 3 serves as nuclei to induce the cubic to rhombohedral transition, hampering performance. These results allow for a more rational catalyst design and fine-tuning of the operating conditions to ensure optimal and stable performance.}, archive = {J_ANGEW}, author = {Albert Gili and Georg Brösigke and Mudassar Javed and Emiliano Dal Molin and Philipp Isbrücker and Jens-Uwe Repke and Franziska Hess and Aleksander Gurlo and Reinhard Schomäcker and Maged F. Bekheet}, doi = {10.1002/anie.202416990}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416990}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Performance and stability of corundum-type In2O3 catalyst for carbon dioxide hydrogenation to methanol}, volume = {64}, year = {2025}, }
• (2025). Tetrahedral DNA framework-based spherical nucleic acids for efficient siRNA delivery. ANGEW, 64(5), e202416988. (www)

  @article{ , abstract = {Spherical nucleic acids (SNAs) hold substantial therapeutic potential for the delivery of small interfering RNAs (siRNAs). Nevertheless, their potential remains largely untapped due to the challenges of cytosolic delivery. Inspired by the dynamic, spiky architecture of coronavirus, an interface engineering approach based on a tetrahedral DNA framework (tDF) is demonstrated for the development of coronavirus-mimicking SNAs. By exploiting their robustness and precise construction, tDFs are evenly arranged on the surface of core nanoparticles (NPs) with flexible conformations, generating a dynamic, spiky architecture. This spiky architecture in tetrahedral DNA framework-based SNAs (tDF-SNAs) substantially improve siRNAs duplex efficiency from 20 % to 95 %. Meanwhile, tDF-SNAs changed the endocytosis pathway to clathrin-independent cellular engulfment pathway and enhanced the cellular uptake efficiency. Due to these advances, the delivery efficiency of siRNA molecules by tDF-SNAs is 1–2 orders of magnitude higher than that of SNAs, resulting in a 2-fold increase in gene silencing efficacy. These results show promise in the development of bioinspired siRNAs delivery systems for intracellular applications.}, archive = {J_ANGEW}, author = {Jie Li and Xiuhai Mao and Tiantian Zhao and Weina Fang and Yangyang Jin and Mengmeng Liu and Chunhai Fan and Yang Tian}, doi = {10.1002/anie.202416988}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416988}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tetrahedral DNA framework-based spherical nucleic acids for efficient siRNA delivery}, volume = {64}, year = {2025}, }
• (2025). Asymmetric palladium migration for synthesis of chiral-at-cage o-carboranes. ANGEW, 64(5), e202416987. (www)

  @article{ , abstract = {Metal migration strategy can offer BH functionalization of o -carboranes at different positions from where initial bond activation occurs to achieve bifunctionalized o -carboranes in one reaction. We report in this article an enantioselective 3,4-bifunctionalization of o -carboranes via asymmetric Pd migration with a high efficiency and up to 98 % ee. This asymmetric catalysis has a broad substrates scope, leading to the preparation of a class of chiral-at-cage o -carborane derivatives. The enantiocontrol model is suggested on the basis of density functional theory (DFT) results, where the chiral Trost ligand plays a crucial role in this enantioselective Pd migration from exo -alkenyl sp 2 C to the cage B(4) position of o -carborane.}, archive = {J_ANGEW}, author = {Chenyang Guo and Jie Zhang and Yixiu Ge and Zaozao Qiu and Zuowei Xie}, doi = {10.1002/anie.202416987}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416987}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric palladium migration for synthesis of chiral-at-cage o-carboranes}, volume = {64}, year = {2025}, }
• (2025). A new class of oxyhalide solid electrolytes NaNbCl6-2xOx for solid-state sodium batteries. ANGEW, 64(5), e202416979. (www)

  @article{ , abstract = {Sodium-based batteries are gaining momentum due to the abundance and lower cost of sodium compared to lithium. Solid-state sodium batteries can also provide further safety advantages. However, sodium-based solid-state electrolytes (SSEs) that meet all the rigorous requirements, such as high ionic conductivity, oxidative stability with the cathode, and ease of processability, are lacking. We present here a new class of sodium-based oxyhalide electrolytes NaNbCl 6-2x O x with a facile mechanochemical synthesis. The oxyhalide NaNbCl 4 O exhibits close to two orders of magnitude higher ambient-temperature sodium-ion conductivity (1.03×10 −4 S cm −1 ) compared to the halide counterpart NaNbCl 6 (3×10 −6 S cm −1 ). Structural motifs unique to the oxygen content in NaNbCl 6-2x O x are identified with 23 Na and 93 Nb magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy and x-ray diffraction (XRD). Solid-state sodium batteries assembled with NaNbCl 4 O electrolyte and the cobalt- and nickel-free layered Na 0.70 Fe 0.3 Mn 0.65 Al 0.05 O 2 cathode exhibit a maximum discharge capacity of 155 mAh g −1 with good cycle life at ambient temperature.}, archive = {J_ANGEW}, author = {Steven Kmiec and Erick Ruoff and Arumugam Manthiram}, doi = {10.1002/anie.202416979}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416979}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A new class of oxyhalide solid electrolytes NaNbCl6-2xOx for solid-state sodium batteries}, volume = {64}, year = {2025}, }
• (2025). Nitrogen-oxidized tröger's base macrocyclic arenes: Unprecedented enantioselective recognition in water. ANGEW, 64(5), e202416975. (www)

  @article{ , abstract = {Achieving high enantioselectivity with synthetic receptors, particularly in water, remains a significant challenge despite the success seen in natural biological systems. In this study, we introduce a facile synthesis of Tröger's base (TB)-containing macrocyclic arenes ( TBn ), where TB units are linked via methylene bridges, providing the macrocycles with a rigid framework. Oxidation of enantiopure TBn yields corresponding chiral nitrogen oxides ( TBnNO ) with excellent water solubility, attributed to the high polarity of the N−O bond, surpassing the pH limitations of traditional ion-functionalized approaches. Remarkably, TBnNO exhibits exceptional enantioselective recognition toward a wide range of chiral guests in aqueous solution, achieving enantioselectivities as high as 41.0. The underlying mechanism involves a combination of hydrophobic interactions and steric effects caused by rigid chiral cavities. These findings highlight the potential of nitrogen-oxidized macrocycles as a transformative tool for supramolecular application in water.}, archive = {J_ANGEW}, author = {Xiaotong Liang and Ting Zhao and Yanling Shen and Lizhi Fang and Long Chen and Dayang Zhou and Wanhua Wu and Cheng Yang}, doi = {10.1002/anie.202416975}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416975}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nitrogen-oxidized tröger's base macrocyclic arenes: Unprecedented enantioselective recognition in water}, volume = {64}, year = {2025}, }
• (2025). Pyrolysis-free synthesis of synergistic single-Atom/Nanocluster electrocatalysts for hydrogen evolution. ANGEW, 64(5), e202416973. (www)

  @article{ , abstract = {Constructing catalysts that simultaneously contain single atom/metal nanocluster active sites is a promising strategy to enhance the original catalytic behavior and accelerate the catalysis involving multi-electron reactions or multi-intermediates. Herein, the pyrolysis-free synthetic method is developed to integrate single atoms and nanoclusters towards highly satisfactory catalytic performances for both acidic and alkaline hydrogen electrocatalysis. The controllable pyrolysis-free strategy allows the precise modulation of the active centers, realizing the optimization of the adsorption energy and the regulation of the synergistic active components. Specially, the as-prepared catalysts with hybrid single-atom/nanocluster sites exhibited superior catalytic activities for hydrogen evolution in both acidic and alkaline media with low over-potentials at −10 mA cm −2 of 25 mV and 8.6 mV, respectively, combining with outstanding durability towards high current density and methanol poisoning. This work developed a universal synthetic strategy for the single atom/nanocluster synergy systems and addressed the superiority of hybrid single-atom/nanocluster sites.}, archive = {J_ANGEW}, author = {Zhao-Di Wang and Ye Han and Ying-Ying Wang and Shuang-Quan Zang and Peng Peng}, doi = {10.1002/anie.202416973}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416973}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pyrolysis-free synthesis of synergistic single-Atom/Nanocluster electrocatalysts for hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Imidazolate-stabilized Cu(III): Dioxygen to oxides at type 3 copper sites. ANGEW, 64(5), e202416967. (www)

  @article{ , abstract = {Imidazole ligation of metals through histidine is extensive among metalloproteins, yet the role of the imidazol ate conjugate base is often neglected, despite its potential accessibility when bonded to an oxidized metal center. Using synthetic models of oxygenated tyrosinase enzymes ligated exclusively by monodentate imidazoles, we find that deprotonation of the μ 2 -η 2 :η 2 -peroxidodicopper(II) species triggers redox isomerization to an imidazol ate -ligated bis(μ 2 -oxido)dicopper(III) species. Formal two-electron oxidation to Cu(III) remains biologically unprecedented, yet is effected readily by addition of base. Spectrophotometric titrations by UV/Visible/near-IR and copper K-edge X-ray absorption spectroscopies are interpreted most simply as two cooperative, 2H + transformations in which the peroxide O−O is cleaved in the first step. Elaboration from simple imidazoles to a protected histidine extends this isomerization into an amino acid environment. The role of phenolate as a base suggests this four-electron reduction of O 2 is energetically viable in a biological context and requires only two copper centers, which act as two-electron shuttles when imidazole deprotonation assists. This existential precedent of viable imidazol ate intermediates invites speculation into an alternative mechanism for phenol hydroxylation not previously considered at Type 3 copper sites such as tyrosinases. Structural biological evidence suggests imidazolate ligation of copper may be more widespread than generally understood.}, archive = {J_ANGEW}, author = {Tao A. G. Large and William Keown and J. Brannon Gary and Linus Chiang and T. Daniel P. Stack}, doi = {10.1002/anie.202416967}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416967}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Imidazolate-stabilized Cu(III): Dioxygen to oxides at type 3 copper sites}, volume = {64}, year = {2025}, }
• (2025). Integrated monomer synthesis and framework assembly: Achieving isoreticular modulation of hydrogen-bonded organic frameworks. ANGEW, 64(5), e202416966. (www)

  @article{ , abstract = {Systematic construction of isoreticular hydrogen-bonded organic frameworks (HOFs) promises tailored material properties crucial for diverse applications, yet is challenging due to the weak, flexible, and non-directional nature of hydrogen bonds. Herein, we develop an “integrated monomer synthesis-framework assembly” ( ISA ) methodology for constructing a series of isoreticular HOFs. Unlike traditional methods where monomers are first synthesized and then assembled into HOFs, the ISA system employs dicyandiamide rigid hydrogen-bonded hexameric clusters as connecting nodes to covalently react with planarized C 3 -symmetric cyano-precursors ( C 3 -CPs ) to generate diaminotriazine (DAT) monomers, while simultaneously inducing the directional assembly into isoreticular (6,3)-net hcb topological DAT- C 6 -HOFs . The pore sizes and microenvironments of the resulting DAT- C 6 -HOFs can be precisely tuned by varying the structural modulation (length and steric hindrance) of the π-bridge on C 3 -CPs , enabling highly selective sensing towards perfluorooctanoic acid over other homologous molecules, that are difficult to be separated and detected by chromatography. Overall, the ISA methodology facilitates the scalable creation of families of isostructural HOFs and provides a customized structural platform for investigating factors beyond topology that impact the capturing, releasing, and responding to guest molecules.}, archive = {J_ANGEW}, author = {Yanxue Shang and Lishuang Ma and Zixi Kang and Yanfang Wu and Weidong Fan and Rongming Wang and Zifeng Yan and Daofeng Sun and Jingbin Zeng}, doi = {10.1002/anie.202416966}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416966}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated monomer synthesis and framework assembly: Achieving isoreticular modulation of hydrogen-bonded organic frameworks}, volume = {64}, year = {2025}, }
• (2025). On the origin of capacity increase in rechargeable magnesium batteries with manganese oxide cathodes and copper metal current collectors. ANGEW, 64(5), e202416960. (www)

  @article{ , abstract = {Rechargeable magnesium batteries (RMBs), with Cu as positive electrode current collector (CC), typically display a gradual capacity increase with cycling. Whereas the origin of this was suggested in gradual active material electro-activation, the fact that this is prevalent in many positive electrode material systems remains unexplained. Herein, we elucidate the underlying mechanism through a series of multiscale joint operando X-ray characterizations, including operando synchrotron X-ray diffraction and imaging technology. We select a series of manganese oxides as benchmark positive electrodes and find that no magnesium ions are stored within the lattices of these materials, despite an apparent cell capacity increase with cycling. The origin of capacity increase is rooted in the gradual electrochemical corrosion of metallic Cu, release of Cu(I, II) species in electrolyte, and their subsequent redox activity, resulting in apparent electrode capacity gains. Furthermore, the shuttle and redox speciation of Cu ions trigger the irreversible depletion of both the Cu CC (or any other source) and the magnesium metal, ultimately leading to cell failure. Our work suggests the need to reconsider the appropriateness of using Cu as a positive electrode CC for RMBs.}, archive = {J_ANGEW}, author = {Zhao Li and Yi Li and Yang Zhan and Xiaodong Lin and Yingying Yao and Tianshuo Zhao and Fengzhan Sun and Hao Xu and Zhewen Ma and Wei Zhang and Yanling Xue and Xiaolong Li and Alexandru Vlad and Jianxin Zou}, doi = {10.1002/anie.202416960}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416960}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On the origin of capacity increase in rechargeable magnesium batteries with manganese oxide cathodes and copper metal current collectors}, volume = {64}, year = {2025}, }
• (2025). Hydrothermal stability of active sites in cu-exchanged small-pore zeolites for the selective catalytic reduction of NOx. ANGEW, 64(5), e202416954. (www)

  @article{ , abstract = {Combining operando X-ray absorption spectroscopy (XAS) and computational modelling shows unequivocally the distribution of active species in fresh and hydrothermally aged Cu-CHA and Cu-AEI zeolites during NH 3 -assisted selective catalytic reduction of NO x . Four principal species co-exist: (i) Cu I cations coordinated to NH 3 , (ii) Cu I cations coordinated to the zeolite framework, (iii) solvated Cu II cations, and (iv) framework-coordinated Cu II species (Cu II st ) formed upon hydrothermal ageing of the zeolite sample. The Cu II st species were only observed in the hydrothermally aged zeolite samples and are formed upon the interaction of hydrated Cu II cations with extra-framework Al (EFAl) generated during the hydrothermal treatment. These sites are inactive for NO x reduction, leading to a decrease in the catalytic performance of the hydrothermally aged zeolites. Cu II st formation was higher in Cu-CHA (~46 %) than in Cu-AEI (~28 %). The better hydrothermal stability of Cu in the AEI framework is attributed to the tortuous channel structure of AEI that hinders the migration of hydrated Cu II cations during hydrothermal ageing.}, archive = {J_ANGEW}, author = {Mirjam Wenig and Rachit Khare and Andreas Jentys and Johannes A. Lercher}, doi = {10.1002/anie.202416954}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416954}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrothermal stability of active sites in cu-exchanged small-pore zeolites for the selective catalytic reduction of NOx}, volume = {64}, year = {2025}, }
• (2025). Combining simple deformations to elicit complex motions and directed swimming of smart organic crystals with controllable thickness. ANGEW, 64(5), e202416950. (www)

  @article{ , abstract = {The lack of control over the crystal growth in a systematic way currently stands as an unsurmountable impediment to the preparation of dynamic crystals as soft robots; in effect, the mechanical effects of molecular crystals have become a subject of scattered reports that pertain only to specific crystal sizes and actuation conditions, often without the ability to establish or confirm systematic trends. One of the factors that prevents the verification of such performance is the unavailability of strategies for effectively controlling crystal size and aspect ratio, where crystals of serendipitous size are harvested from crystallization solution. Here we devised a water-assisted precipitation method to prepare crystals of chemical variants of 9-anthracene derivatives with various thicknesses that respond to ultraviolet light with simple mechanical effects, including bending, splintering, and rotation. By capitalizing on the robust mechanical flexibility and deformability of crystals, we demonstrate systematic variations in crystal deformation that are further elevated in complexity to construct crystal-based robots capable of controllable motions reminiscent of sailing and humanoid movements. The results illustrate an approach to eliminate one of the critical obstacles towards complete control over the motility of dynamic molecular crystals as microrobots in non-aerial environments.}, archive = {J_ANGEW}, author = {Xiaotong Zhu and Mengyuan Xie and Lin Gao and Liang Li and Panče Naumov and Qi Yu and Guoming Wang}, doi = {10.1002/anie.202416950}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416950}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Combining simple deformations to elicit complex motions and directed swimming of smart organic crystals with controllable thickness}, volume = {64}, year = {2025}, }
• (2025). Theory-guided design of unconventional phase metal heteronanostructures for higher-rate stable li-CO2 and li-air batteries. ANGEW, 64(5), e202416947. (www)

  @article{ , abstract = {Lithium-carbon dioxide (Li-CO 2 ) and Li-air batteries hold great potential in achieving carbon neutral given their ultrahigh theoretical energy density and eco-friendly features. However, these Li-gas batteries still suffer from low discharging-charging rate and poor cycling life due to sluggish decomposition kinetics of discharge products especially Li 2 CO 3 . Here we report the theory-guided design and preparation of unconventional phase metal heteronanostructures as cathode catalysts for high-performance Li-CO 2 /air batteries. The assembled Li-CO 2 cells with unconventional phase 4H/face-centered cubic (fcc) ruthenium-nickel heteronanostructures deliver a narrow discharge-charge gap of 0.65 V, excellent rate capability and long-term cycling stability over 200 cycles at 250 mA g −1 . The constructed Li-air batteries can steadily run for above 150 cycles in ambient air. Electrochemical mechanism studies reveal that 4H/fcc Ru−Ni with high-electroactivity facets can boost redox reaction kinetics and tune discharge reactions towards Li 2 C 2 O 4 path, alleviating electrolyte/catalyst failures induced by the aggressive singlet oxygen from solo decomposition of Li 2 CO 3 .}, archive = {J_ANGEW}, author = {Jingwen Zhou and Zhihang Xu and Kai Cui and Jian-An Yin and Hsiao-Chien Chen and Yunhao Wang and Fu Liu and Tianshuai Wang and Fengkun Hao and Yuecheng Xiong and Cheng Wang and Yangbo Ma and Pengyi Lu and Jinwen Yin and Liang Guo and Xiang Meng and Chenliang Ye and Hao Ming Chen and Ye Zhu and Jian Lu and Zhanxi Fan}, doi = {10.1002/anie.202416947}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416947}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Theory-guided design of unconventional phase metal heteronanostructures for higher-rate stable li-CO2 and li-air batteries}, volume = {64}, year = {2025}, }
• (2025). Electrolyte reconfiguration by Cation/Anion cross-coordination for highly reversible and facile sodium storage. ANGEW, 64(5), e202416939. (www)

  @article{ , abstract = {Hard carbon (HC) materials are promising anodes for sodium-ion batteries (SIBs) owing to low cost, high specific capacity and low working potential. However, the poor compatibility of the electrolyte with HC leads to low initial coulombic efficiency (ICE) and sluggish Na + transport kinetics. Here, we propose an electrolyte reconfiguration strategy based on the hard and soft acid and base (HSAB) theory by introducing methyltriphenylphosphonium bromide (MTPPB). MTPPB can realize a spontaneous cross-coordination solvation structure with NaPF 6 by selective affinity, synchronously optimizing the interfacial chemistry and sodium storage process. The advantages of the chemical π–π bridging of MTPP + -HC and interaction of MTPP + -PF 6 − contribute to preferential and oriented reduction of PF 6 − , forming a low-resistance supramolecular SEI. Additionally, Na + -Br − coordination weakens the Na + -solvent interactions, facilitating Na + de-solvation kinetics. Consequently, the HC||Na cell achieves a superior ICE of 96.6 %, desirable rate capability under 25 °C and invisible capacity decay after 500 cycles at 1 C under −20 °C. The Na 4 Fe 3 (PO 4 ) 2 P 2 O 7 ||HC pouch battery displays a high ICE of 90.3 % and a 15 % increment of energy density under 25 °C. This work provides a guidance through electrolyte reconfiguration engineering for designing practical HC-based SIBs with high energy/power density and long-life span in the extended operating-temperature range.}, archive = {J_ANGEW}, author = {Xin Hou and Shuo Wang and Bo Wang and Yanling Qiu and Mingqin Jiang and Yongfu Tang and Qiong Zheng and Xianfeng Li}, doi = {10.1002/anie.202416939}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416939}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte reconfiguration by Cation/Anion cross-coordination for highly reversible and facile sodium storage}, volume = {64}, year = {2025}, }
• (2025). Formamidinium incorporates into rb-based non-perovskite phases in solar cell formulations. ANGEW, 64(5), e202416938. (www)

  @article{ , abstract = {Organic-inorganic hybrid perovskite materials, such as formamidinium lead iodide (FAPbI 3 ), are among the most promising emerging photovoltaic materials. However, the spontaneous phase transition from the photoactive perovskite phase to an inactive non-perovskite phase complicates the application of FAPbI 3 in solar cells. To remedy this, alkali metal cations, most often Cs + , Rb + or K + , are included during perovskite synthesis to stabilize the photoactive phase. The atomic-level mechanisms of stabilization are complex. While Cs + dopes directly into the perovskite lattice, Rb + does not, but instead forms an additional non-perovskite phase, and the mechanism by which Rb confers increased stability remains unclear. Here, we use 1 H− 87 Rb double resonance NMR experiments to show that FA + incorporates into the Rb-based non-perovskite phases (FA y Rb 1- y Pb 2 Br 5 and δ-FA y Rb 1- y PbI 3 ) for both bromide and iodide perovskite formulations. This is demonstrated by changes in the 1 H and 87 Rb chemical shifts, 1 H− 87 Rb heteronuclear correlation spectra, and 87 Rb{ 1 H} REDOR spectra. Simulation of the REDOR dephasing curves suggests up to ~60 % FA + incorporation into the inorganic Rb-based phase for the bromide system. In light of these results, we hypothesize that the substitution of FA + into the non-perovskite phase may contribute to the greater stability conferred by Rb salts in the synthesis of FA-based perovskites.}, archive = {J_ANGEW}, author = {Ummugulsum Gunes and Michael A. Hope and Yuxuan Zhang and Likai Zheng and Lukas Pfeifer and Michael Grätzel and Lyndon Emsley}, doi = {10.1002/anie.202416938}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416938}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formamidinium incorporates into rb-based non-perovskite phases in solar cell formulations}, volume = {64}, year = {2025}, }
• (2025). Structural bifurcation in the High→Low-spin and Low→High-spin phase transitions explains the asymmetric spin-crossover in [FeL2][BF4]2 (L=2,6-di{pyrazol-1-yl}isonicotinonitrile). ANGEW, 64(5), e202416924. (www)

  @article{ , abstract = {Polycrystalline [FeL 2 ][BF 4 ] 2 (L=2,6-di(pyrazol-1-yl)isonicotinonitrile) exhibits an abrupt hysteretic spin transition near 240 K, with a shoulder on the warming branch whose appearance depends on the sample history. The freshly isolated material is a ca 60 : 40 mixture of triclinic (HS1) and tetragonal (HS2) high-spin polymorphs, which are structurally closely related. Both HS1 and HS2 undergo a high→low-spin transition on cooling at 230±10 K. HS1 transforms to a new triclinic low-spin phase with a doubled unit cell volume (LS3), while HS2 forms a monoclinic low-spin phase (LS4) with similar unit cell dimensions to HS2. Single crystals of LS3 and LS4 both convert to HS1 on rewarming. The low→high-spin transition for LS4 is ca 10 K higher in temperature than for LS3, explaining the asymmetric thermal hysteresis. Powder diffraction, calorimetry and magnetic data show that multiple cycling about the spin-transition leads to slow enrichment of the HS1 and LS3 phases at the expense of HS2 and LS4. That is consistent with the HS2/LS4 fraction of the polycrystalline sample undergoing rare, bifurcated HS2→(LS3+LS4) and LS4→(HS1+HS2) phase transitions. The rate of enrichment of HS1/LS3 differed between these experiments, implying it is sample and/or measurement-dependent. Three other salts of this iron(II) complex and the coordination polymer [Ag( μ -L)]BF 4 are also briefly described.}, archive = {J_ANGEW}, author = {Ahmed Ahmed and Amy Hall and Hari Babu Vasili and Rafal Kulmaczewski and Alexander N. Kulak and Oscar Cespedes and Christopher M. Pask and Lee Brammer and Thomas M. Roseveare and Malcolm A. Halcrow}, doi = {10.1002/anie.202416924}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416924}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural bifurcation in the High→Low-spin and Low→High-spin phase transitions explains the asymmetric spin-crossover in [FeL2][BF4]2 (L=2,6-di{pyrazol-1-yl}isonicotinonitrile)}, volume = {64}, year = {2025}, }
• (2025). Photoinduced bartoli indole synthesis by the oxidative cleavage of alkenes with nitro(hetero)arenes. ANGEW, 64(5), e202416923. (www)

  @article{ , abstract = {Given the unique charm of dipole chemistry, intercepting N−O=C dipoles precisely generated by designed processes to develop novel reactivity has become a seminal challenge. The polar fragmentation of 1,3,2-dioxazolidine species generated through the radical addition of excited nitro(hetero)arenes to alkenes represents a significantly underappreciated mechanism for generating N−O=C dipoles. Herein, we present a photoinduced Bartoli indole synthesis by the oxidative cleavage of alkenes with nitro(hetero)arenes. Various indoles and azaindoles are constructed through the multi-step spontaneous rearrangement of carbonyl imine intermediates generated by the polar fragmentation of 1,3,2-dioxazolidine species. Mechanism studies and DFT calculations support that the reaction involves radical cycloaddition, ozonolysis-type cycloreversion, intramolecular H-shift of carbonyl imines, and 3,3-sigmatropic shift of O-Alkenyl hydroxylamines, etc. The implementation of continuous- flow photochemistry, in particular, significantly enhances efficiency, thereby overcoming obstacles to the commercialization process.}, archive = {J_ANGEW}, author = {Hongyun Qin and Ruihua Liu and Zemin Wang and Feng Xu and Xiaowei Li and Cong Shi and Jiashu Chen and Wenlong Shan and Chao Liu and Pan Xing and Jiqiang Zhu and Xiangqian Li and Dayong Shi}, doi = {10.1002/anie.202416923}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoinduced bartoli indole synthesis by the oxidative cleavage of alkenes with nitro(hetero)arenes}, volume = {64}, year = {2025}, }
• (2025). Constructing tandem fenton-like reaction systems based on structure adaption to boost water contaminant mineralization efficiency. ANGEW, 64(5), e202416921. (www)

  @article{ , abstract = {Mineralization of emerging contaminants by using advanced oxidation processes (AOPs) is a desirable option to ensure water safety, but still challenged by the excessive chemical and/or energy input. Here, we conceptually proposed the tandem reaction system (TRS) of different reactive oxygen species (ROS) based on structure adaption of target contaminants. To construct a model TRS, we first realized highly selective generation of three classical ROS ( 1 O 2 , HO⋅ and SO 4 ⋅ − ) by peroxymonosulfate activation in an electrochemical Fenton-like system, where three replaceable Fe-centered cathodes were rationally designed as electronic mediator. The 1 O 2 +SO 4 ⋅ − -TRS exhibited nearly 100 % mineralization of sulfamethoxazole (SMX), whereas only 34.2 %, 56.2 % and 60.8 % for each of the single 1 O 2 /HO⋅/SO 4 ⋅ − -AOP systems. Mechanism exploration of SMX degradation in TRS evidenced that the initial reaction with 1 O 2 selectively destructed the sulfonamide bridge of SMX to form p -aminobenzenesulfonic acid, which will be vulnerable to sequent SO 4 ⋅ − attack to facilitate mineralization. Successful extendibility of 1 O 2 +SO 4 ⋅ − -TRS to other sulfonamide antibiotics and 1 O 2 +HO⋅-TRS to phenolic and arylcarboxylic compounds, as well as the demonstration of 1 O 2 +SO 4 ⋅ − -TRS in treatment of three actual pharmaceutical wastewaters strongly support that TRS is a powerful and sustainable strategy to enhance the mineralization of emerging contaminants in water.}, archive = {J_ANGEW}, author = {Min Chen and Tian Yang and Qiuxia Lei and Xue Gan and Shun Mao and Hongying Zhao}, doi = {10.1002/anie.202416921}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416921}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing tandem fenton-like reaction systems based on structure adaption to boost water contaminant mineralization efficiency}, volume = {64}, year = {2025}, }
• (2025). Regulating peripheral nitrogen dopants in single-atom catalysts to enhance propane dehydrogenation. ANGEW, 64(5), e202416912. (www)

  @article{ , abstract = {For single-atom catalysts (SACs), the dopants situated near the metal site have demonstrated a significant impact on the catalytic properties. However, the effect of dopants situated further away from the metal centers and their working mechanisms remain to be elucidated. Herein, we conduct density functional theory-driven studies on regulating the peripheral nitrogen dopants in graphene-based SACs, with a particular focus on Ir 1 SAC, for propane dehydrogenation (PDH). It is found that increasing the distance between the N dopant and the Ir 1 site results in a different energy change for the reaction process compared to the dense doping models with only first and second-shell N species. The proposed stochastic doping models demonstrate statistically that increasing the N dopant in farther shells not only enhances the activity of Ir 1 but also maintains a high selectivity for propene, which is verified by experimental tests. The modulation of the d -band center of Ir 1 by stochastic N dopants effectively modifies the binding strength of reaction intermediates, thereby enabling the optimization of the potential energy surface of PDH. These results deepen the understanding of dopant states around metal sites and provide an important implication for the doping engineering in heterogeneous catalysis.}, archive = {J_ANGEW}, author = {Fenfei Wei and Liru Cao and Bingqing Ge and Yang Chen and Xiaoli Pan and Yicong Chai and Rizheng Jing and Xixi Hu and Xiaodong Wang and Jian Lin and Sen Lin}, doi = {10.1002/anie.202416912}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416912}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating peripheral nitrogen dopants in single-atom catalysts to enhance propane dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Stabilizing hydrogen radicals in two-dimensional cobalt-copper mesoporous nanoplates for complete nitrate reduction electrocatalysis to ammonia. ANGEW, 64(5), e202416910. (www)

  @article{ , abstract = {Ambient electrochemical reduction of waste nitrate (NO 3 − ) represents an alternative green route for sustainable ammonia (NH 3 ) electrosynthesis in water. Despites some encouraged achievements, sluggish eight electron and nine proton reduction routes that involve multi-step hydrogenation pathways have severely hindered their NH 3 Faradaic efficiency (FE NH3 ) and yield rate. Herein, we develop a robust two-dimensional mesoporous cobalt-copper (meso-CoCu) nanoplate electrocatalyst that delivers excellent performance of complete NO 3 − reduction reaction (NO 3 RR), including superior FE NH3 of 98.8 %, high NH 3 yield rate of 3.39 mol h −1 g −1 and energy efficiency of 49.8 %, and good cycling stability. Mechanism investigations unveil that active hydrogen (*H) radicals produced from water splitting on Co sites spillover to adjacent Cu sites and further stabilize within confined mesopores, which kinetically promote its coupling hydrogenation reactions of nitrogen intermediates and thus facilitate complete NO 3 RR for favorable NH 3 electrosynthesis. Moreover, meso-CoCu nanoplates perform well as a bifunctional electrocatalyst in the two-electrode coupling system that concurrently synthesizes NH 3 from NO 3 − at cathode and 2,5-furanedicarboxylic acid from 5-hydroxymethylfurfural at anode. This work in stabilizing *H radicals in mesoporous microenvironment provides some insights applied to various hydrogenation reactions for selective electrosynthesis of high value-added chemicals in water.}, archive = {J_ANGEW}, author = {Chenyu Han and Lizhi Sun and Shu Han and Ben Liu}, doi = {10.1002/anie.202416910}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416910}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilizing hydrogen radicals in two-dimensional cobalt-copper mesoporous nanoplates for complete nitrate reduction electrocatalysis to ammonia}, volume = {64}, year = {2025}, }
• (2025). Metal–Organic coordination enhanced metallopolymer electrolytes for wide-temperature solid-state lithium metal batteries. ANGEW, 64(5), e202416897. (www)

  @article{ , abstract = {The practical application of polymer electrolytes is seriously hindered by the inferior Li + ionic conductivity, low Li + transference number ( t Li+ ), and poor interfacial stability. Herein, a structurally novel metallopolymer is designed and synthesized by exploiting a molybdenum (Mo) paddle-wheel complex as a tetratopic linker to bridge organic and inorganic moieties at molecular level. The prepared metallopolymer possesses combined merits of outstanding mechanical and thermal stability, as well as a low glass transition temperature ( T g <−50 °C). Based on this metallopolymer, an advanced metal–organic coordination enhanced metallopolymer electrolyte (MPE) is developed for constructing high-performance solid-state lithium metal batteries (LMBs). Due to the unsaturated coordination of Mo atoms, the uniformly distributed Mo-polyoxometalates (Mo-POMs) in metallopolymer skeleton can effectively immobilize anions (bis(fluorosulfonyl)imide anions, FSI − ) and promote the dissociation of Li salts. Moreover, dynamic metal–organic coordination bonds endow the MPE with re-processability and self-healing, enabling it to accommodate electrode volume changes and maintain good interfacial contact. Consequently, the MPE achieves a competitive ionic conductivity of 0.712 mS cm −1 (25 °C), a high t Li+ (0.625), and a wide electrochemical stability window (>5.0 V). This study presents a unique MPE design based on metal–organic coordination enhanced strategy, providing a promising solution for developing wide-temperature solid-state LMBs.}, archive = {J_ANGEW}, author = {Pei-Chen Zhao and Yaoda Wang and Qi-Sheng Huang and Zhong Jin and Cheng-Hui Li}, doi = {10.1002/anie.202416897}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416897}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal–Organic coordination enhanced metallopolymer electrolytes for wide-temperature solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Intramolecular hydrogen bonds weaken interaction between solvents and small organic molecules towards superior lithium-organic batteries. ANGEW, 64(5), e202416845. (www)

  @article{ , abstract = {The strong interaction between organic electrode materials (OEMs) and electrolyte components induces a high solubility tendency of OEMs, thus hindering the practical application of lithium-organic batteries. Herein, we propose an efficient strategy for intramolecular hydrogen bonds (HBs) to redistribute the charge of OEMs to weaken the interaction with electrolyte components, thereby suppressing their dissolution. For the designed 2,2′,2′′-(2,4,6-trihydroxybenzene-1,3,5-triyl) tris (1H-naphtho[2,3-d]imidazole-4,9-dione) (TPNQ) molecule, the intramolecular HBs (O−H⋅⋅⋅N and N−H⋅⋅⋅O) reduce the charge density of active sites and alter the charge distribution on the molecular skeleton. As a result, TPNQ shows significantly reduced solubility in both ether- and ester-based solvents. In situ measurements and theoretical calculations indicate that the O−H⋅⋅⋅N dominated HB interaction strengthening during the discharging process, which can continuously suppress dissolution. Therefore, the TPNQ cathode displays high cycling stability (no capacity fading over 100 cycles at 0.1 A g −1 ; 88.4 % capacity retention over 1000 cycles at 1 A g −1 ), fast Li + -storage kinetics (211 mAh g −1 at 2 A g −1 ), and surprising low-temperature performances (stability cycles 500 times at −60 °C). Our results offer evidence that the intramolecular HBs strategy is promising in developing robust organic electrode materials for rechargeable batteries.}, archive = {J_ANGEW}, author = {Tianjiang Sun and Weijia Zhang and Mengyao Shi and Diantao Li and Qiong Sun and Min Cheng and Zhanliang Tao}, doi = {10.1002/anie.202416845}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416845}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intramolecular hydrogen bonds weaken interaction between solvents and small organic molecules towards superior lithium-organic batteries}, volume = {64}, year = {2025}, }
• (2025). Controlled helical organization in supramolecular polymers of pseudo-macrocyclic tetrakisporphyrins. ANGEW, 64(5), e202416770. (www)

  @article{ , abstract = {Tetrakisporphyrin monomers with amino acid side chains at each end form intramolecular antiparallel hydrogen-bonds to adopt chirally twisted pseudo-macrocyclic structures that result in right-handed and left-handed ( P )- and ( M )-conformations. The pseudo-macrocyclic tetrakisporphyrin monomers self-assembled to form supramolecular helical pseudo-polycatenane polymers via head-to-head complementary dimerization of the bisporphyrin cleft units in an isodesmic manner. The formation of one-handed supramolecular helical pseudo-polycatenane polymers was confirmed by circular dichroism (CD) spectroscopy. The methyl and iso -propyl groups at the stereogenic center greatly enhanced the induced circular dichroism in the Soret bands of the supramolecular helical pseudo-polycatenane polymers. The induced CDs were reduced upon the introduction of large iso -butyl and tert -butyl groups. Atomic force microscopy revealed well-grown and long supramolecular helical pseudo-polycatenane polymer chains with chain lengths in the range of 361 to 13.6 nm. The right-handed helical chains were established by the self-assembly of the right-handed ( P )-conformation of the pseudo-macrocyclic monomer.}, archive = {J_ANGEW}, author = {Naoka Fujii and Naoyuki Hisano and Takehiro Hirao and Shin-ichi Kihara and Kouta Tanabe and Masaya Yoshida and Shin-ichi Tate and Takeharu Haino}, doi = {10.1002/anie.202416770}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416770}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlled helical organization in supramolecular polymers of pseudo-macrocyclic tetrakisporphyrins}, volume = {64}, year = {2025}, }
• (2025). Polymer films’ residual stress attenuation from the supramolecular complexation with ultra-small nanoparticles for high resolution nanoimprint lithography. ANGEW, 64(5), e202416759. (www)

  @article{ , abstract = {Nanoimprint lithography (NIL) has been broadly applied in the fabrication of nano-patterned polymer films for cost-efficiency and high through-put; however, the intrinsic tradeoff between mechanical strength and residual stress of polymer films significantly limits the NIL resolution while the harsh processing conditions limit its versatile applications to different substrates. Herein, 1 nm metal oxide cluster, phosphotungstic acid (PTA), is used to complex with polyvinyl alcohol (PVA) for high-resolution NIL that can be operated at large-scale and mild conditions. The ultra-small size of PTA enables dense supramolecular interaction with PVA for the diminished crystallinity and accelerated chain dynamics that help relax the residual stress during film casting. Meanwhile, the PTAs serve as supramolecular crosslinkers for the increased modulus of the films (ca. 2 GPa), providing promising dimensional stability required for high-resolution NIL. Simple casting the aqueous blend on a master mold successfully gives a residual stress-free film with sub-2 nm resolution at wafer scale (>100 cm 2 ). The mild processing at ambient condition permits broad NIL applications to diverse substrates, e.g., integrated circuit chips, compact discs, PET nano gratings and even delicate bio-surfaces.}, archive = {J_ANGEW}, author = {Jiadong Chen and Shenglin Yao and Bin Wang and Qiang Yu and Binghui Xue and Panchao Yin}, doi = {10.1002/anie.202416759}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416759}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polymer films’ residual stress attenuation from the supramolecular complexation with ultra-small nanoparticles for high resolution nanoimprint lithography}, volume = {64}, year = {2025}, }
• (2025). Mesoporous electrodes enhance the electrocatalytic performance of [FeFe]-hydrogenase. ANGEW, 64(5), e202416658. (www)

  @article{ , abstract = {The metalloenzyme [FeFe]-hydrogenase is of interest to future biotechnologies targeting the production of “green” hydrogen (H 2 ). We recently developed a simple two-step functionalized procedure to immobilize the [FeFe]-hydrogenase from Clostridium pasteurianum (“ Cp I”) on mesoporous indium tin oxide (ITO) electrodes to achieve elevated H 2 production with high operational stability and current densities of 8 mA cm −2 . Here, we use a combination of atomic force microscopy (AFM), scanning electron microscopy (SEM) and electrochemical quartz crystal microbalance (EQCM) to understand how mesoporous ITO stabilizes and activates Cp I for electroenzymatic H 2 production. Examination of the topography and morphology of the mesoporous ITO surface revealed a hierarchical morphology containing cavities and well-defined nanoparticle agglomerates. Any potential effect of mesoporosity was investigated by comparing the stability and electroenzymatic activity of Cp I on mesoporous ‘nanoITO’ and planar ITO, where we determined that Cp I has a higher turnover frequency and adsorbs with greater stability (with respect to electroenzymatic activity over time) to nanoITO surfaces.}, archive = {J_ANGEW}, author = {Sophie Webb and Astrit Veliju and Plinio Maroni and Ulf-Peter Apfel and Thomas Happe and Ross D. Milton}, doi = {10.1002/anie.202416658}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mesoporous electrodes enhance the electrocatalytic performance of [FeFe]-hydrogenase}, volume = {64}, year = {2025}, }
• (2025). Industry-level electrocatalytic CO2 to CO enabled by 2D mesoporous ni single atom catalysts. ANGEW, 64(5), e202416629. (www)

  @article{ , abstract = {Electrocatalytic CO 2 reduction reaction (eCO 2 RR) has captivated widespread attentions, yet achieving the requisite efficiency, selectivity and stability for industrial applications poses a persistent challenge. Here, we report the synthesis of 2D mesoporous Ni single atom catalysts in N-doped carbon framework via a bottom-up interfacial assembly strategy. The 2D mesoporous Ni−N−C catalyst showcases an ultrathin thickness (~6.7 nm) with well-distributed 5 to 40 nm-width mesopores in plane and a high surface area. As a result, the Ni single atom sites with a high density (~6.0 wt %) are almost completely exposed and can be accessible, and the mass transfer can be greatly promoted even at high current densities. Thus, a high current density of 446 mA cm −2 with >95 % CO selectivity in a flow cell can be obtained. Concurrently, the catalyst demonstrates an impressive stability, maintaining a 50-hours continuous electrolysis in the membrane electrode assembly test and achieving an energy efficiency of 42 %. Finite element analysis reveals that the 2D mesoporous design enhances CO 2 diffusion, ensuring efficient adsorption and swift CO desorption at high current densities. Our study paves a way for the fabrication of 2D mesoporous single atom catalysts with nearly 100 % accessibility and expedited mass transport.}, archive = {J_ANGEW}, author = {Yao Ma and Taishi Xiao and Kerun Zhu and Wei Zhang and Ziqing Yin and Angang Dong and Zhengzong Sun and Dongyuan Zhao and Wei Li}, doi = {10.1002/anie.202416629}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416629}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Industry-level electrocatalytic CO2 to CO enabled by 2D mesoporous ni single atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Programmable self-assembly from two-dimensional nanosheets to spiral, twisted and branched nanostructures. ANGEW, 64(5), e202416624. (www)

  @article{ , abstract = {Self-assembly of nanomaterials into hierarchical structure is of great interest to fabricate functional materials. However, programmable design of the assembled structures remains a great challenge. Herein, we reported a programmable self-assembly strategy to customize the assembled structure. The self-assembly strategy is designed to orderly transform the two-dimensional (2D) Ca ions assembled F127 nanosheets (Ca-F127 NSs) into spiral nanosheet structures (S-Ca-F127 NSs), branched nanosheet structures (B-Ca-F127 NSs), branched-spiral nanosheet structures (B-S-Ca-F127 NSs), and twisted-branched structures (T-Ca-F127 NBs). Wide-angle X-ray scattering (WAXS) and X-ray absorption spectroscopy (XAS) indicate that these different structures maintain the same orthorhombic phase and Ca-O octahedral coordination structure. Selected area electron diffraction (SAED) in the double-tilt liquid nitrogen cooling holder identifies the Eshelby twist in the twisted structures, demonstrating the spiral structure are formed by screw dislocation growth. Cryo-electron microscopy (cryo-EM) proves the oriented epitaxial growth in the B-Ca-F127 NSs. Furthermore, the formation mechanisms of spiral structure and branched structure can be recombined to form complex hierarchical structures. The epitaxial growth along screw dislocation can lead to the formation of B-S-Ca-F127 NSs, while the twisted epitaxial growth in the screw dislocation can lead to the formation of T-Ca F127 NBs.}, archive = {J_ANGEW}, author = {Haohui Hu and Wei Jiang and Xiao Han and Geng Wu and Haoran Wang and Yi Shi and Dayin He and Xianhui Ma and Xun Hong}, doi = {10.1002/anie.202416624}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416624}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programmable self-assembly from two-dimensional nanosheets to spiral, twisted and branched nanostructures}, volume = {64}, year = {2025}, }
• (2025). Optical control of TRPM8 channels with photoswitchable menthol. ANGEW, 64(5), e202416549. (www)

  @article{ , abstract = {Transient receptor potential melastatin 8 (TRPM8) channels are well known as sensors for cold temperatures and cooling agents such as menthol and icilin and these channels are tightly regulated by the membrane lipid phosphoinositol-4,5-bisphosphate (PIP 2 ). Since TRPM8 channels emerged as promising drug targets for treating pain, itching, obesity, cancer, dry eye disease, and inflammation, we aimed at developing a high-precision TRPM8 channel activator, to achieve spatiotemporal control of TRPM8 activity with light. In this study, we designed, synthesized and characterized the first photoswitchable TRPM8 activator azo-menthol (AzoM). AzoM enables optical control of endogenously and heterologously expressed TRPM8 channels with UV and blue light which is demonstrated by performing patch-clamp experiments. Moreover, AzoM facilitates the reliable determination of activation, inactivation, and deactivation kinetics thereby providing further insights into the channel gating. Using AzoM, the specific roles of individual amino acids for AzoM or PIP 2 binding and for sensitization by PIP 2 can be elucidated. Altogether, AzoM represents as a high-precision pharmaceutical tool for reversible control of TRPM8 channel function that enhances our biophysical understanding of TRPM8 channels and holds the potential to support the development of novel pharmaceuticals.}, archive = {J_ANGEW}, author = {Jasmin Becker and Clara S. Ellerkmann and Hannah Schmelzer and Christian Hermann and Kyra Lützel and Thomas Gudermann and David B. Konrad and Dirk Trauner and Ursula Storch and Michael Mederos y Schnitzler}, doi = {10.1002/anie.202416549}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416549}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Optical control of TRPM8 channels with photoswitchable menthol}, volume = {64}, year = {2025}, }
• (2025). A BOIMPY dye enables multi-photoinduced electron transfer catalysis: Reaching super-reducing properties. ANGEW, 64(5), e202416472. (www)

  @article{ , abstract = {An established concept to create radical intermediates is photoexcitation of a catalyst to a higher energy intermediate, subsequently leading to a photoinduced electron transfer (PET) with a reaction partner. The known concept of consecutive photoinduced electron transfer (con-PET) leads to catalytically active species even higher in energy by the uptake of two photons. Generally speaking, increased photon uptake leads to a more potent reductant. Here, we report the concept of multi-photoinduced electron transfer catalysis (>2 photons), termed multi-PET, which is enabled by photoinduced one-electron reductions of an organic dye. Further irradiation of the doubly reduced species leads to a photoexcited dianionic super-reductant, which is more potent than Li metal – one of the strongest chemical reductants known. This multi-photon process which is enabled by 390 nm LEDs allows the cleavage of strong carbon-fluorine bonds and reduction of other halides even in very electron-rich substrates. The resulting radicals are quenched by hydrogen atoms or engaged in carbon-carbon and carbon-phosphorus bond formations, highlighting the utility of multi-PET for organic chemistry. In addition, multi-PET enabled Birch-type reductions. Spectroscopic, chemical and computational investigations are presented to gain mechanistic insights.}, archive = {J_ANGEW}, author = {Amit Biswas and Simon Kolb and Sebastian H. Röttger and Arpan Das and Lukas J. Patalag and Partha P. Dey and Swagata Sil and Subir Maji and Soumi Chakraborty and Oliver S. Wenger and Anup Bhunia and Daniel B. Werz and Swadhin K. Mandal}, doi = {10.1002/anie.202416472}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A BOIMPY dye enables multi-photoinduced electron transfer catalysis: Reaching super-reducing properties}, volume = {64}, year = {2025}, }
• (2025). Chemical upcycling of thermoplastics towards thermosets based on dynamic dimethylglyoxime-urethane moiety. ANGEW, 64(5), e202416437. (www)

  @article{ , abstract = {Huge annual consumption of thermoplastics results in the generation of large amounts of waste after their service life. Currently, the most popular recycling method based on mechanically melt-reprocessing deteriorates the material performance and is economically unattractive, which makes it unviable to be implemented in large scale. Herein, we present a chemical upcycling strategy that can transform dimethylglyoxime-urethane based thermoplastic waste into thermoset product with superior mechanical properties and higher economic values than the initial one. It is found that the dimethylglyoxime-urethane moiety has dynamic nature, endowing the material with open-loop upcycling ability. By removing the dimethylglyoxime segment via a simple sublimation process, the material structure is transformed from linear molecular into crosslinked network. More interestingly, the transformation is reversible, and the regenerated crosslinked network can be transformed back to linear molecule by returning the removed dimethylglyoxime segment to the material, which means the upcycled product can be recycled again after its service life. Our linear/crosslinked transformation strategy provide a new option for recycling thermoplastic waste.}, archive = {J_ANGEW}, author = {Qiao Sun and Ling Liu and Jianye Zhang and Xiaohua Chang and Jianwen Chen and Zenghe Liu and Yutian Zhu}, doi = {10.1002/anie.202416437}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416437}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical upcycling of thermoplastics towards thermosets based on dynamic dimethylglyoxime-urethane moiety}, volume = {64}, year = {2025}, }
• (2025). Upcycling of polyamide wastes to tertiary amines using mo single atoms and rh nanoparticles. ANGEW, 64(5), e202416436. (www)

  @article{ , abstract = {The pursuit of sustainable practices through the chemical recycling of polyamide wastes holds significant potential, particularly in enabling the recovery of a range of nitrogen-containing compounds. Herein, we report a novel strategy to upcycle polyamide wastes to tertiary amines with the assistance of H 2 in acetic acid under mild conditions (e.g., 180 °C), which is achieved over anatase TiO 2 supported Mo single atoms and Rh nanoparticles. In this protocol, the polyamide is first converted into diacetamide intermediates via acidolysis, which are subsequently hydrogenated into corresponding carboxylic acid monomers and tertiary amines in 100 % selectivity. It is verified that Mo single atoms and Rh nanoparticles work together to activate both amide bonds of the diacetamide intermediate, and synergistically catalyze its hydrodeoxygenation to form tertiary amine, but this catalyst is ineffective for hydrogenation of carboxylic acid. This work presents an effective way to reconstruct various polyamide wastes into tertiary amines and carboxylic acids, which may have promising application potential.}, archive = {J_ANGEW}, author = {Minhao Tang and Ji Shen and Fengtao Zhang and Yanfei Zhao and Tao Gan and Wei Zeng and Rongxiang Li and Dingsheng Wang and Buxing Han and Zhimin Liu}, doi = {10.1002/anie.202416436}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416436}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Upcycling of polyamide wastes to tertiary amines using mo single atoms and rh nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Direct synthesis of semiconductive AgBiS2 NC inks toward high-efficiency, low-cost and environmental-friendly solar cells. ANGEW, 64(5), e202416369. (www)

  @article{ , abstract = {Silver bismuth sulfide nanocrystals (AgBiS 2 NCs) embody a pioneering heavy-metal-free photovoltaic material renowned for its ultrahigh absorption coefficient, offering promising opportunities for advancing the field of ultra-thin and biocompatible solar cells. Currently, the fabrication of AgBiS 2 NC photovoltaic devices relies on hot-injection synthesis and subsequent tedious ligand exchange, leading to high production cost, complex processes and environmental pollution. Here, we developed a direct-synthesis (DS) method without ligand-exchange for AgBiS 2 NC semiconductive inks, significantly simplifying the material preparation and device fabrication processes. The synthesis cost of AgBiS 2 inks (17.0 $ g −1 ) is over an order of magnitude lower than the traditional method (203.5–275.2 $ g −1 ). Through optimizing synthesis and device structure, a champion power conversion efficiency of 9.32 % was achieved, aligning with the highest reported efficiency (9.17 %) based on ligand-exchanged methods. In addition, our DS-AgBiS 2 inks show excellent storage stability for over ten months. More importantly, the life cycle assessment (LCA) indicates drastically reduced energy consumption as well as environmental and human health impact for our strategy. The low-cost and scalable synthesis approach for AgBiS 2 NC semiconductive inks present a “greener” pathway for the commercial applications of NC optoelectronics.}, archive = {J_ANGEW}, author = {Lin Yuan and Yang Li and Yang Liu and Kunyuan Lu and Guozheng Shi and Xiang Sun and Yong Li and Xinyu Dong and Yuran Xiao and Lizhen Huang and Zeke Liu and Wanli Ma}, doi = {10.1002/anie.202416369}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416369}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct synthesis of semiconductive AgBiS2 NC inks toward high-efficiency, low-cost and environmental-friendly solar cells}, volume = {64}, year = {2025}, }
• (2025). Guanidinium-stapled helical peptides for targeting protein-protein interactions. ANGEW, 64(5), e202416348. (www)

  @article{ , abstract = {Peptide stapling has emerged as a versatile approach in drug discovery to reinforce secondary structure elements especially α-helices and improve properties of linear bioactive peptides. Inspired by the prevalence of arginine in protein-protein and protein-DNA interfaces, we investigated guanidinium-stapling as a means to constrain helical peptides. Guanidinium stapling was readily achieved on solid support, utilizing two orthogonally protected lysine or unatural α-amino acid residues with an amino function. This method allows for easy modulation of the nature and size of the staple as well as helix propensity. Evaluating a set of guanidinium-stapled peptides for their interaction with different protein targets identified several binders with increased target affinity. X-ray structure determination of four complexes revealed that all stapled peptides adopt a helical conformation upon protein binding. Notably, the disubstituted guanidinium generally exhibits a distinct cis / trans conformation and, in one instance, retains a conserved hydrogen bond with the protein surface. By identifying, for the first time, the guanidinium moiety as an effective helical peptide stapling group, this research significantly expands the repertoire of α-helix stapling techniques for the creation of useful protein mimics.}, archive = {J_ANGEW}, author = {Camille Perdriau and Anaïs Luton and Katharina Zimmeter and Maxime Neuville and Claire Saragaglia and Carole Peluso-Iltis and Judit Osz and Brice Kauffmann and Gavin W. Collie and Natacha Rochel and Gilles Guichard and Morgane Pasco}, doi = {10.1002/anie.202416348}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Guanidinium-stapled helical peptides for targeting protein-protein interactions}, volume = {64}, year = {2025}, }
• (2025). Orientational compatibility modulation of ligands in low-symmetry multi-cavity discrete coordination cages by neighbouring cage participation. ANGEW, 64(5), e202416332. (www)

  @article{ , abstract = {Complexation of Pd(II) with a designer unsymmetrical bis-monodentate ligand (2 : 4 ratio) yielded a specific Pd 2 L 4 type “single-cavity discrete coordination cage” (SCDCC), from a pool of 4 isomeric structures. The observed selctivity is attributed to inherent orientational preference of the ligand strands around the metal centers. Crafting a short coordinating arm at either ends of the bis-monodentate ligand (i.e the longer-arm) produced a pair of unsymmetrical isomeric tris-monodentate ligands; whereas crafting the same short-arm at both ends of the ligand gives an unsymmetrical tetrakis-monodentate ligand. Complexation of Pd(II) with either of the isomeric tris-monodenate ligands (3 : 4 ratio) resulted in corresponding low-symmetry “multi-cavity discrete coordination cage” MCDCC having two conjoined cavities, though the inherent relative orientational preference of the longer arms is not achievable in these cages. The enforced orientation is sustained by “Neighbouring Cage Participation” (NCP). However, one-pot combination of Pd(II), with a mixture of isomeric tris-monodentate ligands in 3 : 2 : 2 ratio produced an integratively self-sorted mixed-ligated MCDCC from a pool of 31 structures. Also, mixing Pd(II) with the tetrakis-monodentate ligand produced a MCDCC having three conjoined cavities. The inherent orientational preference of longer-arm of the ligand strands is retained in the mixed-ligated double-cavity and the homo-ligated triple cavity cages.}, archive = {J_ANGEW}, author = {Ashish Kumar and Shobhana Krishnaswamy and Dillip Kumar Chand}, doi = {10.1002/anie.202416332}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416332}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orientational compatibility modulation of ligands in low-symmetry multi-cavity discrete coordination cages by neighbouring cage participation}, volume = {64}, year = {2025}, }
• (2025). Regulated li+ solvation via competitive coordination mechanism of organic cations for high voltage and fast charging lithium metal batteries. ANGEW, 64(5), e202416092. (www)

  @article{ , abstract = {Li + solvation exerted a decisive effect on electrolyte physicochemical properties. Suitable tuning for Li + solvation enabled batteries to achieve unexpected performance. Here, we introduced inert organic cations to compete with Li + for combining electrolyte molecules to modulate Li + coordination in the electrolyte. The relevance between the number of cationic sites in organic cations and the competitive solvation ability was explored. The organic cations with multiple cationic sites attracted solvent molecules and anions away from Li + to form new solvated shell, improving the Li + transport kinetics and desolvation process in electrolyte while enhancing electrolyte oxidation tolerance. Moreover, electrostatic shielding provided by organic cations and anion-derived robust SEI promoted uniform and rapid Li + deposition on Li electrodes. With the positive effect of organic cations, Li||LiCoO 2 (LCO) batteries showed high specific capacity (136.46 mAh g −1 ) at high charge/discharge rate (10 C). Furthermore, Li||LCO batteries exhibited good capacity retention (70 % after 500 cycles) at 4.6 V charge cut-off voltage. This work provides fresh insights for the optimization of electrolytes and battery performance.}, archive = {J_ANGEW}, author = {Jiangtao Yu and Xinyu Ma and Xiuyang Zou and Yin Hu and Mingchen Yang and Yuanli Cai and Feng Yan}, doi = {10.1002/anie.202416092}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulated li+ solvation via competitive coordination mechanism of organic cations for high voltage and fast charging lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Balancing activity and selectivity in two-electron oxygen reduction through first coordination shell engineering in cobalt single atom catalysts. ANGEW, 64(5), e202416070. (www)

  @article{ , abstract = {The electrochemical two-electron oxygen reduction reaction (2e − ORR) offers a potentially cost-effective and eco-friendly route for the production of hydrogen peroxide (H 2 O 2 ). However, the competing 4e − ORR that converts oxygen to water limits the selectivity towards hydrogen peroxide. Accordingly, achieving highly selective H 2 O 2 production under low voltage conditions remains challenging. Herein, guided by first-principles density functional theory (DFT) calculations, we show that modulation the first coordination sphere in Co single atom catalysts (Co−N−C catalysts with Co-N x O 4-x sites), specifically the replacement of Co−N bonds with Co−O bonds, can weaken the *OOH adsorption strength to boost the selectivity towards H 2 O 2 (albeit with a slight decrease in ORR activity). Further, by synthesizing a series of N-doped carbon-supported catalysts with Co-N x O 4-x active sites, we were able to validate the DFT findings and explore the trade-off between catalytic activity and selectivity for 2e − ORR. A catalyst with trans -Co-N 2 O 2 sites exhibited excellent catalytic activity and H 2 O 2 selectivity, affording a H 2 O 2 production rate of 12.86 and an half-cell energy-efficiency of 0.07 during a 100-hours H 2 O 2 production test in a flow-cell.}, archive = {J_ANGEW}, author = {Kai Sun and Ruihu Lu and Yuge Liu and Joshua Webb and Muhammad Hanif and Yufei Zhao and Ziyun Wang and Geoffrey I. N. Waterhouse}, doi = {10.1002/anie.202416070}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Balancing activity and selectivity in two-electron oxygen reduction through first coordination shell engineering in cobalt single atom catalysts}, volume = {64}, year = {2025}, }
• (2025). Operando evolution of a hybrid metallic alloy interphase for reversible aqueous zinc batteries. ANGEW, 64(5), e202416047. (www)

  @article{ , abstract = {Aqueous Zn-ion batteries (AZIBs) are widely acknowledged as viable future energy storage solutions, particularly for low-cost stationary applications. However, the interfacial instability of zinc anodes represents a major challenge to the commercial potential of Zn-ion systems, promoting an array of side reactions including spontaneous corrosion, hydrogen evolution, and dendrite growth that destabilize cell performance, lower Coulombic efficiency and ultimately lead to early cell failure. While other commercially relevant battery systems benefit from a spontaneously forming solid electrolyte interphase, no such layer forms in AZIBs. Herein, we have designed and engineered an operando evolved metallic alloy interphase for AZIBs. This interfacial layer is initially deposited in the form of a thin film of Ag and In, but develops in situ to become an intimate mix of an Ag x Zn y alloy and metallic indium. Importantly, this dual-heterometallic layer acts to synergistically regulate the migration of zinc ions through the alloy interphase and enables the dense and planar deposition of Zn, simultaneously overcoming all major drivers of Zn anode degradation. Symmetric and full cells containing this modified metallic zinc anode exhibit stable electrochemical performance, offering high-capacity retention. Hence, this scalable approach represents a viable route towards the commercial utilization of this energy storage system.}, archive = {J_ANGEW}, author = {Mingqiang Liu and Kai Yang and Qiming Xie and Nantao Hu and Mingzheng Zhang and Ruwei Chen and Wei Zhang and Jichao Zhang and Feng Shao and Hongzhen He and Roby Soni and Xiaoxia Guo and Jinlong Yang and Guanjie He and Feng Pan and Lu Yao and Thomas S. Miller}, doi = {10.1002/anie.202416047}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202416047}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Operando evolution of a hybrid metallic alloy interphase for reversible aqueous zinc batteries}, volume = {64}, year = {2025}, }
• (2025). Calcium chemistry as a new member of post-lithium battery family: What can we learn from sodium and magnesium systems. ANGEW, 64(5), e202415942. (www)

  @article{ , abstract = {The development of next-generation battery technologies needs to consider their environmental impact throughout the whole cycle life, which has brought new chemistries based on earth-abundant elements into the spotlight. Rechargeable calcium batteries are such an emerging technology, which shows the potential to provide high cell voltage and high energy density close to lithium-ion batteries. Additionally, the use of Ca 2+ as a charge carrier renders significant sustainable values. Although pioneering work on the electrochemistry of Ca has been carried out for more than half a century, demonstration of reversible Ca 0 /Ca 2+ redox chemistry in non-aqueous media was only achieved within the past decade. In this review, we will present recent development of rechargeable calcium batteries, focusing on mainly the similarities but also differences between Ca chemistry and other post-lithium chemistry. According to the periodic nature of elements, magnesium (an alkaline earth element as Ca) and sodium (a diagonally adjacent element to Ca) have similar chemical properties to Ca in various aspects. We shall elaborate on how the solution chemistry, metal behaviors and transport mechanisms of Ca-ions can be better understood in light of the established principles in the respective Mg/Na systems. We hope the discussion will inspire synergetic development between Ca batteries and other post-lithium systems.}, archive = {J_ANGEW}, author = {Zhenyou Li and Shuangshuang Cui and Joachim Häcker and Maryam Nojabaee and Maximilian Fichtner and Guanglei Cui and Zhirong Zhao-Karger}, doi = {10.1002/anie.202415942}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202415942}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Calcium chemistry as a new member of post-lithium battery family: What can we learn from sodium and magnesium systems}, volume = {64}, year = {2025}, }
• (2025). Entropy-repaired solvation structure strategy for high-efficiency phosphate-based localized high-concentration electrolytes in potassium batteries. ANGEW, 64(5), e202415923. (www)

  @article{ , abstract = {The safety and cycling stability of potassium-ion batteries (PIBs) are deeply associated with potassium-ion electrolytes. However, due to the weak Lewis acidity of potassium ions, localized high-concentration electrolytes in PIBs are prone to excessive weak solvation. Herein, we propose an entropy repair strategy for the solvation structure of potassium ions and systematically design a moderately weakly solvated high-entropy localized high-concentration electrolyte. The repaired electrolyte can achieve an average stable Coulombic efficiency of 99.4 % on the Cu collector surface. The potassium symmetric battery can be stably cycled for over 10000 h under a high current density of 0.5 mA cm −2 and a large deposition capacity of 1 mAh cm −2 . The potassium metal pouch cell, using K 1.92 Fe[Fe(CN) 6 ] 0.94 ⋅0.5H 2 O as the cathode, maintains a capacity retention of 87.5 % after 2000 cycles at a current density of 0.5 A g −1 . Even when the current density is increased tenfold from 0.1 A g −1 , the battery still retains 67.1 % of its capacity. Additionally, due to the introduction of multiple solvents, the potassium metal battery with perylene-3,4,9,10-tetracarboxylic dianhydride as the cathode can maintain reversible capacities of 94.0 and 77.3 mAh g −1 and operate stably at ambient temperatures of −20 and −40 °C, respectively.}, archive = {J_ANGEW}, author = {Zeyu Yuan and Jiaying Liao and Lili Song and Anni Chen and Jiling Su and Jie Wang and Xiaosi Zhou}, doi = {10.1002/anie.202415923}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202415923}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Entropy-repaired solvation structure strategy for high-efficiency phosphate-based localized high-concentration electrolytes in potassium batteries}, volume = {64}, year = {2025}, }
• (2025). Degradable radical polymer cathode for lithium battery with long-term cycling capability. ANGEW, 64(5), e202415915. (www)

  @article{ , abstract = {Polymer-based organic electrodes for rechargeable batteries are attractive due to their design flexibility, sustainability, and environmental compatibility. Unfortunately, waste management of conventional polymer materials typically involves incineration, which emits greenhouse gases. Consequently, degradable polymers should be ideal candidates for future green batteries. However, to date, degradable polymer electrodes have been rarely reported. The few that have been developed exhibit very low capacities (<40 mAh g −1 ) and poor cycle stability (<100 cycles). Herein, we synthesize a degradable polymer cathode for lithium batteries by copolymerizing 2,3-dihydrofuran with TEMPO-containing norbornene derivatives. This polymer cathode demonstrates a two-electron redox reaction charge storage mechanism, exhibiting a high reversible capacity of 100.4 mAh g −1 and a long cycle life of over 1000 cycles. Furthermore, under a mild acidic environment, this polymer electrode material undergoes complete decomposition via the hydrolysis of enol ethers, confirmed by gel permeation chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. These encouraging results shed light on the design of degradable polymer electrodes.}, archive = {J_ANGEW}, author = {Chang Liu and Xin Huang and Xiaomeng Yu and Zhaoqi Wang and Yun Shen and Shouyi Yuan and Yonggang Wang}, doi = {10.1002/anie.202415915}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202415915}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Degradable radical polymer cathode for lithium battery with long-term cycling capability}, volume = {64}, year = {2025}, }
• (2025). Enhancing battery longevity by regulating the solvation chemistry of organic iodide. ANGEW, 64(5), e202415589. (www)

  @article{ , abstract = {For rechargeable zinc-iodine batteries, the low electrical conductivity of iodine and the easy dissolution of polyiodide in the electrolyte need to be carefully managed to ensure efficient operation. Herein, we introduce an organic iodized salt, formamidinium iodide (CH 5 N 2 I), to modulate the solvation structure of iodide ion, aimed to improve the reaction kinetics of iodine for reversible redox conversion. The participation of formamidinium ion (FA + ) into solvation structure leads to the formation of the favorable FAIZn(H 2 O) 4 2+ complex, facilitating easier desolvation for redox conversion with iodine. Consequently, the inhibited formation of soluble polyiodide efficiently suppresses self-discharging and improves reversible redox conversion. Specifically, the fabricated battery demonstrates extraordinary cycling stability, with 90.1 % capacity retention after 10,000 cycles and high coulombic efficiency of 99.6 %. These results provide inspiring principles to develop organohalide materials for high-performance rechargeable batteries through the solvation modification and interface regulation strategies.}, archive = {J_ANGEW}, author = {Wenshuo Shang and Qianwu Chen and Song Chen and Jintao Zhang}, doi = {10.1002/anie.202415589}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202415589}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing battery longevity by regulating the solvation chemistry of organic iodide}, volume = {64}, year = {2025}, }
• (2025). Precision activity-based α-amylase probes for dissection and annotation of linear and branched-chain starch-degrading enzymes. ANGEW, 64(5), e202415219. (www)

  @article{ , abstract = {α-Amylases are the workhorse enzymes of starch degradation. They are central to human health, including as targets for anti-diabetic compounds, but are also the key enzymes in the industrial processing of starch for biofuels, corn syrups, brewing and detergents. Dissection of the activity, specificity and stability of α-amylases is crucial to understanding their biology and allowing their exploitation. Yet, functional characterization lags behind DNA sequencing and genomics; and new tools are required for rapid analysis of α-amylase function. Here, we design, synthesize and apply new branched α-amylase activity-based probes. Using both α-1,6 branched and unbranched α-1,4 maltobiose activity-based probes we were able to explore the stability and substrate specificity of both a panel of human gut microbial α-amylases and a panel of industrially relevant α-amylases. We also demonstrate how we can detect and annotate the substrate specificity of α-amylases in the complex cell lysate of both a prominent gut microbe and a diverse compost sample by in-gel fluorescence and mass spectrometry. A toolbox of starch-active activity-based probes will enable rapid functional dissection of α-amylases. We envisage activity-based probes contributing to better selection and engineering of enzymes for industrial application as well as fundamental analysis of enzymes in human health.}, archive = {J_ANGEW}, author = {Isabelle B. Pickles and Yurong Chen and Olga Moroz and Haley A. Brown and Casper de Boer and Zachary Armstrong and Nicholas G. S. McGregor and Marta Artola and Jeroen D. C. Codée and Nicole M. Koropatkin and Herman S. Overkleeft and Gideon J. Davies}, doi = {10.1002/anie.202415219}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202415219}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precision activity-based α-amylase probes for dissection and annotation of linear and branched-chain starch-degrading enzymes}, volume = {64}, year = {2025}, }
• (2025). Topological and morphological membrane dynamics in giant lipid vesicles driven by monoolein cubosomes. ANGEW, 64(5), e202414970. (www)

  @article{ , abstract = {Lipid nanoparticles have important applications as biomedical delivery platforms and broader engineering biology applications in artificial cell technologies. These emerging technologies often require changes in the shape and topology of biological or biomimetic membranes. Here we show that topologically-active lyotropic liquid crystal nanoparticles (LCNPs) can trigger such transformations in the membranes of giant unilamellar vesicles (GUVs). Monoolein (MO) LCNPs, cubosomes with an internal nanostructure of space group incorporate into 1,2-dioleoyl- sn -glycero-3-phosphocholine (DOPC) GUVs creating excess membrane area with stored curvature stress. Using time-resolved fluorescence confocal and lattice light sheet microscopy, we observe and characterise various life-like dynamic events in these GUVs, including growth, division, tubulation, membrane budding and fusion. Our results shed new light on the interactions of LCNPs with bilayer lipid membranes, providing insights relevant to how these nanoparticles might interact with cellular membranes during drug delivery and highlighting their potential as minimal triggers of topological transitions in artificial cells.}, archive = {J_ANGEW}, author = {Zexi Xu and Andrew Booth and Michael Rappolt and Michelle Peckham and Arwen I. I. Tyler and Paul A. Beales}, doi = {10.1002/anie.202414970}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202414970}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Topological and morphological membrane dynamics in giant lipid vesicles driven by monoolein cubosomes}, volume = {64}, year = {2025}, }
• (2025). Photocatalytic oxidative coupling of methane to ethane using CO2 as a soft oxidant over the Au/TiO2−Vo nanosheets. ANGEW, 64(5), e202414814. (www)

  @article{ , abstract = {Photocatalytic oxidative coupling of methane (OCM) offers an appealing route for converting greenhouse gas into valuable C 2 hydrocarbons. However, O 2, as the most commonly used oxidant, tends to result in inevitable overoxidation and waste of methane feedstock. Herein, we first report a photocatalytic OCM using CO 2 as a soft oxidant for C 2 H 6 production under mild conditions, where an efficient photocatalyst with unique interface sites is designed and constructed to facilitate CO 2 adsorption and activation, while concurrently boosting CH 4 dissociation. As a prototype, the Au quantum dots anchored on oxygen-deficient TiO 2 nanosheets are fabricated, where the Au−V o −Ti interface sites for CO 2 adsorption and activation are collectively disclosed by in situ Kelvin probe force microscopy, quasi in situ X-ray photoelectron spectroscopy and theoretical calculations. Compared with single metal site, the Au−V o −Ti interface sites exhibit the lower CO 2 adsorption energy and decrease the energy barrier of the *CO 2 hydrogenation step from 1.05 to 0.77 eV via Au−C and Ti−O dual-site bonding. The adsorbed CO 2 on the photocatalyst reduces the energy barrier of *CH 4 dissociation to *CH 3 from 2.13 to 1.59 eV, contributing to CH 4 oxidation. Additionally, in situ Fourier-transform infrared spectroscopy unveils the Au site facilitates ethane production by engaging in *CH 3 −Au interaction and accelerating CH 3 −CH 3 coupling. Thus, the photocatalyst demonstrates a high C 2 H 6 evolution rate of 2.60 mmol g −1 h −1 for OCM using CO 2 as the soft oxidant, surpassing most of previously reported photocatalysts regardless of OCM and nonoxidative coupling of methane. This work highlights the importance of soft oxidants for improving oxidation reaction efficiency and provides atomic scale insight into the design of photocatalysts for CH 4 conversion.}, archive = {J_ANGEW}, author = {Mingyu Wu and Juncheng Zhu and Yang Wu and Siying Liu and Kai Zheng and Shumin Wang and Bangwang Li and Jing Li and Chengyuan Liu and Jun Hu and Junfa Zhu and Yang Pan and Yongfu Sun and Yi Xie}, doi = {10.1002/anie.202414814}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202414814}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalytic oxidative coupling of methane to ethane using CO2 as a soft oxidant over the Au/TiO2−Vo nanosheets}, volume = {64}, year = {2025}, }
• (2025). Catalytic asymmetric synthesis and applications of stereogenic β′-methyl enones and β,β′-dimethyl ketones. ANGEW, 64(5), e202414449. (www)

  @article{ , abstract = {The “Magic Methyl” effect has received tremendous interest in medicinal chemistry due to the significant pharmacological and physical modification of properties that have been observed upon introducing a methyl group, especially, a stereogenic methyl group into potential chiral drug candidates. The prevalence of stereogenic β-methyl ketone structural motifs in bioactive compounds and natural products has long motivated the development of enantioselective strategies toward their synthesis. Herein, we have rationally designed a Rh-catalyzed asymmetric monohydrogenation of readily-available β′-methylene conjugated enones with high efficiency and remarkable site-selectivity and enantioselectivity control for the practical construction of enantioenriched β′-methyl unsaturated enones that are difficult to access by other methods. Control experiments revealed that the conjugated C=C bond in β′-methylene conjugated enones plays a significant role in enhancing the reactivity of monohydrogenation. This methodology is applicable for the preparation of chiral β,β′-dimethyl ketones through consecutive double asymmetric hydrogenation of β,β′-dimethylene ketones. Detailed mechanistic investigation and DFT studies further provided strong support for a unique processive catalysis pathway for double asymmetric hydrogenation. The synthetic utilities have been demonstrated in the concise synthesis of several key intermediates for bioactive molecules, asymmetric total synthesis of natural products ( S )-(+)- ar -Turmerone and ( S )-(+)-dihydro- ar -Turmerone, and two C 2 -symmetric chiral spirocyclic diol frameworks.}, archive = {J_ANGEW}, author = {Zongpeng Zhang and Bing-Ke Zhu and Zhi-Yuan Yi and Ting Fang and Zhuan Jin and Ling He and Bo-Bin Chen and Xiaotian Qi and Chun-Jiang Wang}, doi = {10.1002/anie.202414449}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202414449}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic asymmetric synthesis and applications of stereogenic β′-methyl enones and β,β′-dimethyl ketones}, volume = {64}, year = {2025}, }
• (2025). Spontaneous emergence of lipid vesicles in a coacervate-based compartmentalized system. ANGEW, 64(5), e202414372. (www)

  @article{ , abstract = {The spontaneous emergence of lipid vesicles in the absence of evolved biological machinery represents a major challenge for bottom-up synthetic biology. We show that coacervate microdroplets could create a compartmentalized environment that enriches lipid molecules and facilitates their spontaneous assembly into lipid vesicles. These vesicles can escape from the coacervate microdroplets in a continuous process under non-equilibrium conditions, resembling a constant production process akin to a “primitive enzyme” factory assembly line. These findings significantly extend our understanding of the intricate interaction between lipid molecules and coacervate microdroplets, shedding light on the emergence of cellular systems and offering a new perspective on the conditions necessary for the development of life on Earth.}, archive = {J_ANGEW}, author = {Chengying Yin and Xinran Yu and Baohu Wu and Liangfei Tian}, doi = {10.1002/anie.202414372}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202414372}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spontaneous emergence of lipid vesicles in a coacervate-based compartmentalized system}, volume = {64}, year = {2025}, }
• (2025). Self-assembled peptide-derived proteolysis-targeting chimera (PROTAC) nanoparticles for tumor-targeted and durable PD-l1 degradation in cancer immunotherapy. ANGEW, 64(5), e202414146. (www)

  @article{ , abstract = {Proteolysis-targeting chimeras (PROTACs) are a promising technique for the specific and durable degradation of cancer-related proteins via the ubiquitin-proteasome system in cancer treatment. However, the therapeutic efficacy of PROTACs is restricted due to their hydrophobicity, poor cell permeability and insufficient tumor-targeting ability. Herein, we develop the self-assembled peptide-derived PROTAC nanoparticles (PT-NPs) for precise and durable programmed death-ligand 1 (PD−L1) degradation in targeted tumors. The PT-NPs with an average size of 211.8 nm are formed through the self-assembly of amphiphilic peptide-derived PROTAC (CLQKTPKQC-FF-ALAPYIP), comprising a PD−L1-targeting ‘CLQKTPKQC’, self-assembling linker ‘FF’ and E3 ligase recruiting ‘ALAPYIP’. Particularly, PT-NPs strongly bind to tumor cell surface PD−L1 to form PD−L1/PT-NPs complex, then internalized through receptor-mediated endocytosis and degraded in lysosomes. Second, free PROTACs released from PT-NPs to the cytoplasm further induce the durable proteolysis of cytoplasmic PD−L1 via the ubiquitin-proteasome system. In colon tumor models, intravenously injected PT-NPs accumulate significantly at targeted tumor tissues through nanoparticle-derived passive and active targeting. At the targeted tumor tissues, PT-NPs promote durable PD−L1 degradation and ultimately trigger a substantial antitumor immune response. Collectively, this study provides valuable insights into the rational design of self-assembled peptide-derived PROTAC nanoparticles to ensure noticeable accuracy and enhanced efficacy in cancer treatment.}, archive = {J_ANGEW}, author = {Yujeong Moon and Hanhee Cho and Jinseong Kim and Sukyung Song and Jung Yeon Park and Jin Young Min and Eun Hee Han and Yongju Kim and Joon-Kyung Seong and Man Kyu Shim and Kwangmeyung Kim}, doi = {10.1002/anie.202414146}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202414146}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled peptide-derived proteolysis-targeting chimera (PROTAC) nanoparticles for tumor-targeted and durable PD-l1 degradation in cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Ultrafast synthesis of IrB1.15 nanocrystals for efficient chlorine and hydrogen evolution reactions in saline water. ANGEW, 64(5), e202414021. (www)

  @article{ , abstract = {The production of storable hydrogen fuel through water electrolysis powered by renewable energy sources such as solar, marine, geothermal, and wind energy presents a promising pathway toward achieving energy sustainability. Nevertheless, state-of-the-art electrolysis requires support from ancillary processes which often incur financial and energy costs. Developing electrolysers capable of directly operating with water that contains impurities can circumvent these processes. Herein, we demonstrate the efficient and durable electrolysis of saline water to produce chlorine gas (Cl 2 ) and hydrogen using structurally ordered IrB 1.15 , synthesized through ultrafast joule heating. IrB 1.15 exhibits remarkable performance, achieving overpotentials of 75 mV for the chlorine evolution reaction (CER) and 12 mV for hydrogen evolution reactions (HER) at current densities of 10 mA cm −2 . Moreover, IrB 1.15 displays a durability of over 90 h towards both CER and HER. Density functional theory reveals that IrB 1.15 has adsorption energies significantly closer to 0 eV for Cl and H, compared to IrO 2 and Pt/C. Furthermore, in situ Raman investigations reveal that Ir in IrB 1.15 serves as the active center for CER, while the introduction of B atoms to Ir lattices mitigates the formation of absorbed hydrogen species on the Ir surface, thereby enhancing the performance of IrB 1.15 in HER.}, archive = {J_ANGEW}, author = {Tingting Liu and Zhangsen Chen and Sixiang Liu and Pan Wang and Zonghua Pu and Gaixia Zhang and Shuhui Sun}, doi = {10.1002/anie.202414021}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202414021}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrafast synthesis of IrB1.15 nanocrystals for efficient chlorine and hydrogen evolution reactions in saline water}, volume = {64}, year = {2025}, }
• (2025). Ultrafast luminescence detection with selective adsorption of carbon disulfide in a Gold(I) Metal−Organic framework. ANGEW, 64(5), e202413830. (www)

  @article{ , abstract = {Although a widely used and important industrial chemical, carbon disulfide (CS 2 ) poses a number of hazards due to its volatility and toxicity. As such, the development of multifunctional materials for the selective capture and easy recognition of CS 2 is one of the crucial issues. Herein, we demonstrate completely selective CS 2 adsorption among trials involving H 2 O, alcohols, volatile organic compounds (including thiol derivatives), N 2 , H 2 , O 2 , CH 4 , CO, NO, and CO 2 . We also showcase its fine detection using remarkable luminescent response in a gold(I)-based metal−organic framework (MOF) of {Zn II (pz)[Au I (CN) 2 ] 2 } (pz=pyrazine; 1 ) with a two-fold interpenetration network. Ex situ single crystal X-ray diffraction for 1 and CS 2 -accommodated 1 suggested that the Au ⋅⋅⋅ Au atoms are not only luminescent centers but also act as interaction sites for CS 2 modulating the Au ⋅⋅⋅ Au contacts. These experiments revealed the specificity of CS 2 and how changes in the CS 2 -induced structure. Based on the obtained structural transformation, 1 exhibited a sensitive detecting ability for CS 2 with an ultrafast response time of less than 10 s. Moreover, ex situ time-resolved photoluminescence analyses developed in this work implied that CS 2 varied the energetic relaxation at the excited states related to the luminescent efficiency of the resultant MOF system.}, archive = {J_ANGEW}, author = {Haruka Yoshino and Masaki Saigo and Takumi Ehara and Kiyoshi Miyata and Ken Onda and Jenny Pirillo and Yuh Hijikata and Shinya Takaishi and Wataru Kosaka and Ken-ichi Otake and Susumu Kitagawa and Hitoshi Miyasaka}, doi = {10.1002/anie.202413830}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202413830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrafast luminescence detection with selective adsorption of carbon disulfide in a Gold(I) Metal−Organic framework}, volume = {64}, year = {2025}, }
• (2025). A self-adjuvanting large pore 2D covalent organic framework as a vaccine platform. ANGEW, 64(5), e202413020. (www)

  @article{ , abstract = {Vaccines are one of the greatest human achievements in public health, as they help prevent the spread of diseases, reduce illness and death rates, saving thousands of lives with few side effects. Traditional vaccine development is centered around using live attenuated or inactivated pathogens, which is expensive and has resulted in vaccine-associated illnesses. Advancements have led to the development of safer subunit vaccines, which contain recombinant proteins isolated from pathogens. Their short half-life and small size make most subunit vaccines less immunogenic. Here, we introduce a large pore 2D covalent organic framework (COF), PyCOFamide, as a promising solution for an effective subunit platform. Our study demonstrates that simple adsorption of a model antigen, ovalbumin (OVA), onto PyCOFamide (OVA@COF) significantly enhances humoral and cell-mediated immune response compared to free OVA. OVA@COF exhibited heightened immune cell activation and acts as an antigen reservoir, facilitating antigen-presenting cell trafficking to the draining lymph nodes, amplifying the humoral immune response. Additionally, the breakdown of the COF releases monomers that adjuvant the activation of immune cells vital to creating strong immunity. This platform offers a potential avenue for safer, more effective subunit vaccines.}, archive = {J_ANGEW}, author = {Yalini H. Wijesundara and Niyati Arora and Ryanne N. Ehrman and Thomas Sinclair Howlett and Trevor M. Weyman and Ikeda Trashi and Orikeda Trashi and Sneha Kumari and Shashini D. Diwakara and Wendy Tang and Milinda C. Senarathna and Katarzyna H. Drewniak and Ziqi Wang and Ronald A. Smaldone and Jeremiah J. Gassensmith}, doi = {10.1002/anie.202413020}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202413020}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A self-adjuvanting large pore 2D covalent organic framework as a vaccine platform}, volume = {64}, year = {2025}, }
• (2025). Carbon defects as highly active sites for gold detection and recovery. ANGEW, 64(5), e202412997. (www)

  @article{ , abstract = {The use of precious metals (PMs) in many areas, such as printed circuit boards, catalysts, and target drugs, is increasing due to their unique physical and chemical properties, but their recovery remains a great challenge in terms of zero-valent PMs as the final product. We report a highly hydrophilic carbon dot (CD) as a reductant (electron donor), in which the defects in CD served as efficient active sites for zero-valent PMs recovery with an electron-donating capacity of ~1.7 mmol g −1 . The reduction of gold follows a two-step dynamic model characterized by the formation of nano-gold nuclei (initial rapid electron transfer process) followed by an Ostwald ripening process (subsequent slow process). Finite element method (FEM) simulation shows that the reaction efficiency and confinement effect of AuCl 4 − ions are positively correlated with defect density, indicating that the quantitative control of carbon defect density is the key to enhancing reduction activity. Combining density functional theory (DFT) with XPS and FTIR technology, we found that the electron is transferred from CD to Au(III) via hydrogen bonding. This nano carbon material can be exploited to recover gold from e-waste water directly, with the characteristics of reducing energy consumption and avoiding environmental pollution.}, archive = {J_ANGEW}, author = {Ting Zhang and Zhenmin Xu and Ya Xie and Shuyuan Dong and Zhenpeng Guo and Wanting Wang and Yao Chen and Xufang Qian and Han Yu and Zhenfeng Bian}, doi = {10.1002/anie.202412997}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202412997}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon defects as highly active sites for gold detection and recovery}, volume = {64}, year = {2025}, }
• (2025). Efficient direct air capture in industrial cooling towers mediated by electrochemical CO2 release. ANGEW, 64(5), e202412697. (www)

  @article{ , abstract = {Direct air capture (DAC) is a promising technology for mitigating global climate change but suffers from low efficiency, small scale, and high cost due to the dilute atmospheric CO 2 , limited size of air contactors, and heat-driven CO 2 release. Here, we propose combining DAC with widely used industrial cooling towers to extract CO 2 from the air and using electrolysis to release the captured CO 2 at room temperature. We first prepare a buffered absorbent solution consisting of sodium glycinate, glycine, and sodium chloride for effective CO 2 capture from the air, solving the incompatibility problem of the cooling towers with conventional absorbents. Next, we employ a three-chamber electrolyzer for efficient release (≥95 %) of the captured CO 2 with high purity (≥98 %) by constant current electrolysis at room temperature, bypassing the conventional energy-intensive heating process. The entire DAC system can operate stably for multiple cycles, and the mechanism for consecutive CO 2 capture and release is uncovered. This work reveals the great potential of running DAC in industrial cooling towers coupled with electrochemically-driven CO 2 release, opening up new avenues for curbing the increasingly severe climate change.}, archive = {J_ANGEW}, author = {Ao-Chuan Zheng and Ye-Bin Zou and Lin Du and Qiang Zhang and Kim Daasbjerg and Xin-Ming Hu}, doi = {10.1002/anie.202412697}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202412697}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient direct air capture in industrial cooling towers mediated by electrochemical CO2 release}, volume = {64}, year = {2025}, }
• (2025). Opening the hysteresis loop in ferromagnetic Fe3GeTe2 nanosheets through functionalization with TCNQ molecules. ANGEW, 64(5), e202412425. (www)

  @article{ , abstract = {Ferromagnetic metal Fe 3 GeTe 2 (FGT), whose structure exhibits weak van-der-Waals interactions between 5-atom thick layers, was subjected to liquid-phase exfoliation (LPE) in N-methyl pyrrolidone (NMP) to yield a suspension of nanosheets that were separated into several fractions by successive centrifugation at different speeds. Electron microscopy confirmed successful exfoliation of bulk FGT to nanosheets as thin as 6 nm. The ferromagnetic ordering temperature for the nanosheets gradually decreased with the increase in the centrifugation speed used to isolate the 2D material. These nanosheets were resuspended in NMP and treated with an organic acceptor, 7,7,8,8-tetracyano-quinodimethane (TCNQ), which led to precipitation of FGT-TCNQ composite. The formation of the composite material is accompanied by charge transfer from the FGT nanosheets to TCNQ molecules, generating TCNQ⋅ − radical anions, as revealed by experimental vibrational spectra and supported by first principles calculations. Remarkably, a substantial increase in magnetic anisotropy was observed, as manifested by the increase in the coercive field from nearly zero in bulk FGT to 1.0 kOe in the exfoliated nanosheets and then to 5.4 kOe in the FGT-TCNQ composite. The dramatic increase in coercivity of the composite suggests that functionalization with redox-active molecules provides an appealing pathway to enhancing magnetic properties of 2D materials.}, archive = {J_ANGEW}, author = {Govind Sasi Kumar and Alberto M. Ruiz and Jaime Garcia-Oliver and Yan Xin and José J. Baldoví and Michael Shatruk}, doi = {10.1002/anie.202412425}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202412425}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Opening the hysteresis loop in ferromagnetic Fe3GeTe2 nanosheets through functionalization with TCNQ molecules}, volume = {64}, year = {2025}, }
• (2025). Sulfonated hydroxyaryl-tetrazines with increased pKa for accelerated bioorthogonal click-to-release reactions in cells. ANGEW, 64(5), e202411713. (www)

  @article{ , abstract = {Bioorthogonal reactions that enable switching molecular functions by breaking chemical bonds have gained prominence, with the tetrazine-mediated cleavage of trans -cyclooctene caged compounds (click-to-release) being particularly noteworthy for its high versatility, biocompatibility, and fast reaction rates. Despite several recent advances, the development of highly reactive tetrazines enabling quantitative elimination from trans -cyclooctene linkers remains challenging. In this study, we present the synthesis and application of sulfo-tetrazines, a class of derivatives featuring phenolic hydroxyl groups with increased acidity constants (p K a ). This unique property leads to accelerated elimination and complete release of the caged molecules within minutes. Moreover, the inclusion of sulfonate groups provides a valuable synthetic handle, enabling further derivatization into sulfonamides, modified with diverse substituents. Significantly, we demonstrate the utility of sulfo-tetrazines in efficiently activating fluorogenic compounds and prodrugs in living cells, offering exciting prospects for their application in bioorthogonal chemistry.}, archive = {J_ANGEW}, author = {Michal Rahm and Patrick Keppel and Veronika Šlachtová and Rastislav Dzijak and Martin Dračínský and Simona Bellová and Paul E. Reyes-Gutiérrez and Sille Štěpánová and Jakob Raffler and Eva Tloušťová and Helena Mertlíková-Kaiserová and Hannes Mikula and Milan Vrabel}, doi = {10.1002/anie.202411713}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202411713}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sulfonated hydroxyaryl-tetrazines with increased pKa for accelerated bioorthogonal click-to-release reactions in cells}, volume = {64}, year = {2025}, }
• (2025). Transforming aryl-tetrazines into bioorthogonal scissors for systematic cleavage of trans-cyclooctenes. ANGEW, 64(5), e202411707. (www)

  @article{ , abstract = {Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, the tetrazine-triggered elimination of cleavable trans -cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding of the underlying mechanisms, application of this reaction remains limited by the cumulative performance trade-offs (i.e., click kinetics, release kinetics, release yield) of existing tools. Efficient release has been restricted to tetrazine scaffolds with comparatively low click reactivity, while highly reactive aryl-tetrazines give only minimal release. By introducing hydroxyl groups onto phenyl- and pyridyl-tetrazine scaffolds, we have developed a new class of ‘bioorthogonal scissors’ with unique chemical performance. We demonstrate that hydroxyaryl-tetrazines achieve near-quantitative release upon accelerated click reaction with cleavable trans -cyclooctenes, as exemplified by click-triggered activation of a caged prodrug, intramitochondrial cleavage of a fluorogenic probe (turn-on) in live cells, and rapid intracellular bioorthogonal disassembly (turn-off) of a ligand-dye conjugate.}, archive = {J_ANGEW}, author = {Martin Wilkovitsch and Walter Kuba and Patrick Keppel and Barbara Sohr and Andreas Löffler and Stefan Kronister and Andres Fernandez del Castillo and Marion Goldeck and Rastislav Dzijak and Michal Rahm and Milan Vrabel and Dennis Svatunek and Jonathan C. T. Carlson and Hannes Mikula}, doi = {10.1002/anie.202411707}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202411707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transforming aryl-tetrazines into bioorthogonal scissors for systematic cleavage of trans-cyclooctenes}, volume = {64}, year = {2025}, }
• (2025). Designing zwitterionic bottlebrush polymers to enable long-cycling quasi-solid-state lithium metal batteries. ANGEW, 64(5), e202409500. (www)

  @article{ , abstract = {Ionogel polymer electrolyte (IPE), incorporating ionic liquid (IL) within a polymer matrix, presents a promising avenue for safe quasi-solid-state lithium metal batteries. However, sluggish Li + kinetics, resulting from the formation of [Li(anion) n ] −(n−1) clusters and the occupation of Li + transport sites by organic cations, limit their practical applications. In this study, we have developed zwitterionic bottlebrush polymers-based IPE with promoted Li + conduction by employing poly(sulfobetaine methacrylate)-grafted poly(vinylidene fluoride- co -chlorotrifluoroethylene) (PVC- g -PSBMA) bottlebrushes as matrices of IL. The grafted zwitterionic side chains greatly facilitate the dissociation of [Li(anion) n ] −(n−1) clusters to produce more movable Li + . Moreover, the positively charged −NR 4 + groups in zwitterionic side chains effectively restrain anions migration, while the negatively charged −SO 3 − groups immobilize IL cations, preventing them from occupying Li + hopping sites and reducing the energy barrier for Li + migration. These synergistic effects contribute to a notable ionic conductivity (7.5×10 −4 S cm −1 ) and Li + transference number (0.62) of PVC- g -PSBMA IPE at 25 °C. As a result, PVC- g -PSBMA IPE enables ultralong-term (over 6500 h) reversible and stable Li plating/stripping in Li||Li symmetric cells. Remarkably, the assembled Li||LiFePO 4 full batteries demonstrate unprecedented cycling stability of more than 2000 cycles with a superior capacity retention of 93.7 %.}, archive = {J_ANGEW}, author = {Shimei Li and Hu Hong and Dedi Li and Xinru Yang and Shixun Wang and Dechao Zhang and Qi Xiong and Zhaodong Huang and Chunyi Zhi}, doi = {10.1002/anie.202409500}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202409500}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Designing zwitterionic bottlebrush polymers to enable long-cycling quasi-solid-state lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Photoredox-catalyzed decarboxylation of oxetane-2-carboxylic acids and unique mechanistic insights. ANGEW, 64(5), e202405125. (www)

  @article{ , abstract = {Oxetanes are valuable motifs in medicinal chemistry applications, with demonstrated potential to serve as bioisosteres for an array of functional groups. Through the visible-light-mediated photoredox hydrodecarboxylation of 2-aryl oxetane 2-carboxylic acids this work enables access to the products of a [2+2]-photocycloaddition between alkenes and aryl aldehydes without the challenges associated with a traditional UV-light-mediated Paternò-Büchi reaction. Investigation into the hydrodecarboxylation mechanism reveals substrate-dependent modes of initiation under the conditions reported herein. Divergence in diastereomeric outcome is observed, with mechanistic probes elucidating key hydrogen-bonding and steric interactions.}, archive = {J_ANGEW}, author = {Elvis C. McFee and Katie A. Rykaczewski and Corinna S. Schindler}, doi = {10.1002/anie.202405125}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {5}, pages = {e202405125}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoredox-catalyzed decarboxylation of oxetane-2-carboxylic acids and unique mechanistic insights}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Generation of bis(pentafluorophenyl)boron enolates from alkynes and their catalyst-free alkyne coupling. ANGEW, 64(4), e202580462. (www)

  @article{ , archive = {J_ANGEW}, author = {Masatoshi Shibuya and Souta Yuruka and Yoshihiko Yamamoto}, doi = {10.1002/anie.202580462}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202580462}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Generation of bis(pentafluorophenyl)boron enolates from alkynes and their catalyst-free alkyne coupling}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: A Knowledge–Data dual-driven framework for predicting the molecular properties of rechargeable battery electrolytes. ANGEW, 64(4), e202580461. (www)

  @article{ , archive = {J_ANGEW}, author = {Yu-Chen Gao and Yu-Hang Yuan and Suozhi Huang and Nan Yao and Legeng Yu and Yao-Peng Chen and Qiang Zhang and Xiang Chen}, doi = {10.1002/anie.202580461}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202580461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: A Knowledge–Data dual-driven framework for predicting the molecular properties of rechargeable battery electrolytes}, volume = {64}, year = {2025}, }
• (2025). Back cover: Four-state electrochromism in tris(4-aminophenyl)amine- terephthalaldehyde-based covalent organic framework (Angew. chem. int. ed. 4/2025). ANGEW, 64(4), e202423134. (www)

  @article{ , archive = {J_ANGEW}, author = {Gaurav Kumar Silori and Szu-Chia Chien and Li-Chiang Lin and Kuo-Chuan Ho}, doi = {10.1002/anie.202423134}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202423134}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Four-state electrochromism in tris(4-aminophenyl)amine- terephthalaldehyde-based covalent organic framework (Angew. chem. int. ed. 4/2025)}, volume = {64}, year = {2025}, }
• (2025). Jordan hobbs. ANGEW, 64(4), e202423083. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202423083}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202423083}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Jordan hobbs}, volume = {64}, year = {2025}, }
• (2025). Nikolaos eleftheriadis. ANGEW, 64(4), e202423022. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202423022}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202423022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nikolaos eleftheriadis}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Programmable C−N bond formation through radical-mediated chemistry in plasma-microdroplet fusion (Angew. chem. int. ed. 4/2025). ANGEW, 64(4), e202422498. (www)

  @article{ , archive = {J_ANGEW}, author = {Alexander J. Grooms and Robert T. Huttner and Mackenzie Stockwell and Leah Tadese and Isabella M. Marcelo and Anthony Kass and Abraham K. Badu-Tawiah}, doi = {10.1002/anie.202422498}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202422498}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Programmable C−N bond formation through radical-mediated chemistry in plasma-microdroplet fusion (Angew. chem. int. ed. 4/2025)}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Modular design and scaffold-synthesis of multi-functional fluorophores for targeted cellular imaging and pyroptosis (Angew. chem. int. ed. 4/2025). ANGEW, 64(4), e202422492. (www)

  @article{ , archive = {J_ANGEW}, author = {Lei Zhang and Chunhui Wang and Yuanyuan Li and Haiyang Wang and Kunhui Sun and Siyu Lu and Yahui Wang and Su Jing and Thorben Cordes}, doi = {10.1002/anie.202422492}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202422492}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Modular design and scaffold-synthesis of multi-functional fluorophores for targeted cellular imaging and pyroptosis (Angew. chem. int. ed. 4/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Subcellular compartment-specific amplified imaging of metal ions via ribosomal RNA-regulated DNAzyme sensors (Angew. chem. int. ed. 4/2025). ANGEW, 64(4), e202422488. (www)

  @article{ , archive = {J_ANGEW}, author = {Deyu Yi and Lele Li and Mengyuan Li}, doi = {10.1002/anie.202422488}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202422488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Subcellular compartment-specific amplified imaging of metal ions via ribosomal RNA-regulated DNAzyme sensors (Angew. chem. int. ed. 4/2025)}, volume = {64}, year = {2025}, }
• (2025). Giant polyketide synthases biosynthesize a marine polyether biotoxin. ANGEW, 64(4), e202419620. (www)

  @article{ , abstract = {Prymnesin toxins were probably the direct cause of the environmental catastrophe in the Oder river in 2022. They belong to the so-called ladder polyethers, which are among the most toxic non-proteinogenic substances and have caused a whole series of food poisoning in humans and numerous other incidents of fish deaths. Despite massive efforts, the enzymatic machinery has remained enigmatic. In a recent study, researchers at the Scripps Institution of Oceanography and the University of California, San Diego, have uncovered the initial mechanisms by which algae produce these toxins. Crucial to the breakthrough was the methodological advance in sequencing and assembly that allowed the identification and analysis of the largest polyketide synthase (PKS) known to date, named PKZILLA-1 and PKZILLA-2, which enabled, among other things, the confirmation and elucidation of stereocenters. Thus, further investigations into the biosynthesis and other aspects of these highly toxic substances are made possible, which could perhaps make these ′biblical plagues′ predictable.}, archive = {J_ANGEW}, author = {Robin Teufel and Michael Müller}, doi = {10.1002/anie.202419620}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202419620}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Giant polyketide synthases biosynthesize a marine polyether biotoxin}, volume = {64}, year = {2025}, }
• (2025). Stabilization strategies of buried interface for efficient SAM-based inverted perovskite solar cells. ANGEW, 64(4), e202419608. (www)

  @article{ , abstract = {In recent years, self-assembled monolayers (SAMs) anchored on metal oxides (MO) have greatly boosted the performance of inverted (p-i-n) perovskite solar cells (PVSCs) by serving as hole-selective contacts due to their distinct advantages in transparency, hole-selectivity, passivation, cost-effectiveness, and processing efficiency. While the intrinsic monolayer nature of SAMs provides unique advantages, it also makes them highly sensitive to external pressure, posing a significant challenge for long-term device stability. At present, the stability issue of SAM-based PVSCs is gradually attracting attention. In this minireview, we discuss the fundamental stability issues arising from the structural characteristics, operating mechanisms, and roles of SAMs, and highlight representative works on improving their stability. We identify the buried interface stability concerns in three key aspects: 1) SAM/MO interface, 2) SAM inner layer, and 3) SAM/perovskite interface, corresponding to the anchoring group, linker group, and terminal group in the SAMs, respectively. Finally, we have proposed potential strategies for achieving excellent stability in SAM-based buried interfaces, particularly for large-scale and flexible applications. We believe this review will deepen understanding of the relationship between SAM structure and their device performance, thereby facilitating the design of novel SAMs and advancing their eventual commercialization in high-efficiency and stable inverted PVSCs.}, archive = {J_ANGEW}, author = {Xinyu Yu and Xianglang Sun and Zonglong Zhu and Zhong'an Li}, doi = {10.1002/anie.202419608}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202419608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilization strategies of buried interface for efficient SAM-based inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Aptamer and DNAzyme based colorimetric biosensors for pathogen detection. ANGEW, 64(4), e202418725. (www)

  @article{ , abstract = {The detection of pathogens is critical for preventing and controlling health hazards across clinical, environmental, and food safety sectors. Functional nucleic acids (FNAs), such as aptamers and DNAzymes, have emerged as versatile molecular tools for pathogen detection due to their high specificity and affinity. This review focuses on the in vitro selection of FNAs for pathogens, with emphasis on the selection of aptamers for specific biomarkers and intact pathogens, including bacteria and viruses. Additionally, the selection of DNAzymes for bacterial detection is discussed. The integration of these FNAs into colorimetric biosensors has enabled the development of simple, cost-effective diagnostic platforms. Both non-catalytic and catalytic colorimetric biosensors are explored, including those based on gold nanoparticles, polydiacetylenes, protein enzymes, G-quadruplexes, and nanozymes. These biosensors offer visible detection through color changes, making them ideal for point-of-care diagnostics. The review concludes by highlighting current challenges and future perspectives for advancing FNA-based colorimetric biosensing technologies for pathogen detection.}, archive = {J_ANGEW}, author = {Rudi Liu and Jiuxing Li and Bruno J. Salena and Yingfu Li}, doi = {10.1002/anie.202418725}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202418725}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Aptamer and DNAzyme based colorimetric biosensors for pathogen detection}, volume = {64}, year = {2025}, }
• (2025). Confinement effects and manipulation strategies of nanocomposite membranes towards molecular separation. ANGEW, 64(4), e202418649. (www)

  @article{ , abstract = {Materials featuring well-defined nanoscale channels offer inherent advantages in the selective transport of gases, liquids, and ions, making them pivotal in applications such as molecular separation, catalysis and energy storage. A crucial challenge lies in assembling ordered nanochannel structures and translating these microscopic architectures into macroscopic regular distributions to enhance performance. Nanocomposites provide a promising solution by incorporating nanoscale material (e.g., filler) that significantly enhances macroscale properties of matrix (e.g., polymer). In this review, we spotlight nanocomposite membranes nanocomposite membranes that utilize confinement effects between filler and matrix to precisely control nanochannel apertures, surface properties, and channel distribution for efficient separation of target systems. We discussed the underlying design principles, channel architectures, and strategies for optimizing polymer-filler interfaces and nanochannel manipulation within functional membranes. Emphasis is placed on the fundamental mechanisms of mass transport, and the structure-property-performance relationships within the nanocomposite membranes towards molecular separation. This work aims to provide a comprehensive understanding of how these nanocomposite membranes can be further developed to meet the demands of industrial and environmental applications.}, archive = {J_ANGEW}, author = {Guining Chen and Haipeng Zhu and Guozhen Liu and Gongping Liu and Wanqin Jin}, doi = {10.1002/anie.202418649}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202418649}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Confinement effects and manipulation strategies of nanocomposite membranes towards molecular separation}, volume = {64}, year = {2025}, }
• (2025). Generation of bis(pentafluorophenyl)boron enolates from alkynes and their catalyst-free alkyne coupling. ANGEW, 64(4), e202417910. (www)

  @article{ , abstract = {Carbon-carbon bond forming reactions are powerful synthetic tools for constructing organic molecular frameworks. In this study, strongly Lewis acidic bis(pentafluorophenyl)boron enolates were generated from alkynes through oxygen transfer from 2,6-dibromopyridine N -oxide using tris(pentafluorophenyl)borane [B(C 6 F 5 ) 3 ]. Boron enolates were highly reactive owing to the strong Lewis acidity of the boron centers, and thus immediately coupled with alkynes. N -Ethynylphthalimide reacted as an alkyne with 2,6-dibromopyridine N -oxide and B(C 6 F 5 ) 3 to form a semi-stable bis(pentafluorophenyl)boron enolate through the coordination of the carbonyl group to the boron center. This enolate underwent coupling with another alkyne.}, archive = {J_ANGEW}, author = {Masatoshi Shibuya and Souta Yuruka and Yoshihiko Yamamoto}, doi = {10.1002/anie.202417910}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417910}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Generation of bis(pentafluorophenyl)boron enolates from alkynes and their catalyst-free alkyne coupling}, volume = {64}, year = {2025}, }
• (2025). Single-cell secretome profiling enabled by selective enrichment and NanoLC-MS/MS analysis. ANGEW, 64(4), e202417351. (www)

  @article{ , abstract = {Recent advances in single-cell proteomics enable the direct profiling of thousands of proteins from a single mammalian cell. However, due to the bottlenecks in detecting low-abundance secreted proteins and extracellular vesicle (EV) proteins (collectively referred to as the secretome) against a background of high-abundance proteins in serum-containing culture medium, the comprehensive investigation of the secretome at the single-cell level using nanoLC-MS/MS still remains challenging. Herein, we report a novel single-cell secretome profiling (SCSP) method by integrating the metabolic labeling of newly synthesized proteins, click chemistry-based enrichment, and in situ digestion of the labeled secretome in an alkyne-functionalized capillary micro-reactor, followed by nanoLC-MS/MS analysis. By this method, an average of 389 protein groups were quantified from the secretome of single HeLa cells (n=17), with a total of 752 protein groups confidently identified in the single-cell secretome, which is a significant increase compared to the previously reported targeted analysis limited to dozens of secreted proteins by antibody recognition. These results indicated that our developed SCSP method would provide a powerful tool to gain insights into secretion heterogeneity and intercellular communication at the single-cell level.}, archive = {J_ANGEW}, author = {Yingyun He and Xinxin Liu and Fengjiao Zhu and Zhongpeng Dai and Xiao Li and Linmei Li and Baofeng Zhao and Huiming Yuan and Yao Lu and Zhen Liang and Yukui Zhang and Lihua Zhang}, doi = {10.1002/anie.202417351}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417351}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-cell secretome profiling enabled by selective enrichment and NanoLC-MS/MS analysis}, volume = {64}, year = {2025}, }
• (2025). Electric-field catalysis on carbon nanotubes in electromicrofluidic reactors: Monoterpene cyclizations. ANGEW, 64(4), e202417333. (www)

  @article{ , abstract = {The control over the movement of electrons during chemical reactions with oriented external electric fields (OEEFs) has been predicted to offer a general approach to catalysis. Recently, we suggested that many problems to realize electric-field catalysis in practice under scalable bulk conditions could possibly be solved on multiwalled carbon nanotubes in electromicrofluidic reactors. Here, we selected monoterpene cyclizations to assess the scope of our system in organic synthesis. We report that electric-field catalysis can function by stabilizing both anionic and cationic transition states, depending on the orientation of the applied field. Moreover, electric-field catalysis can promote reactions which are barely accessible by general Brønsted and Lewis acids and field-free anion-π and cation-π interactions, and drive chemoselectivity toward intrinsically disfavored products without the need for pyrene interfacers attached to the substrate to prolong binding to the carbon nanotubes. Finally, interfacing with chiral organocatalysts is explored and evidence against contributions from redox chemistry is provided.}, archive = {J_ANGEW}, author = {Augustina Jozeliūnaitė and Shen-Yi Guo and Naomi Sakai and Stefan Matile}, doi = {10.1002/anie.202417333}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417333}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electric-field catalysis on carbon nanotubes in electromicrofluidic reactors: Monoterpene cyclizations}, volume = {64}, year = {2025}, }
• (2025). Bioinspired synthesis of cucurbalsaminones b and c. ANGEW, 64(4), e202417318. (www)

  @article{ , abstract = {Cucurbalsaminones B ( 1 ) and C ( 2 ) are two abeo -cucurbitane triterpenoids with a unique 5/6/3/6/5-fused ring system and exhibit potent multidrug resistance (MDR)-reversing activity. Herein, we report the first synthesis of these two natural products, both of them were accomplished in 14 steps from commercially available inexpensive resource compound lanosterol. Key features of this synthesis include a biomimetic tandem Wagner–Meerwein type lanostane-to-cucurbitane rearrangement followed by a bioinspired photochemical oxa-di-π-methane (ODPM) rearrangement to complete the skeleton construction and an Eosin Y photoinduced Barton-McCombie deoxygenation to realize the challenging oxidation state adjustment of the sterically hindered C11 position.}, archive = {J_ANGEW}, author = {Mengqing Zhang and Jingjing Wu}, doi = {10.1002/anie.202417318}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417318}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bioinspired synthesis of cucurbalsaminones b and c}, volume = {64}, year = {2025}, }
• (2025). Upconversion/Downshifting circularly polarized luminescence over 1200 nm in a single nanoparticle for optical anticounterfeiting and information encryption. ANGEW, 64(4), e202417223. (www)

  @article{ , abstract = {Multimodal upconversion and downshifting circularly polarized luminescent materials hold significant potential for optical anticounterfeiting applications due to their exceptional chiroptical properties. However, constructing these materials within a single emitter remains challenging. In this study, a conceptual model of multimodal upconversion/downshifting circularly polarized luminescence (CPL) is realized within a single nanoparticle. A new type of nanoparticles with multilayer core–shell architecture is fabricated, capable of delivering upconversion/downshifting luminescence, when excited by a 980 nm laser. Utilizing a co-assembly strategy, multimodal upconversion/downshifting CPL emission, covering a broad emission range from ultraviolet (UV) to the second near-infrared (NIR-II) region, can be realized at the supramolecular level. These chiroptical properties closely follow the chirality of host matrix and are strongly dependent on the distribution mode of nanoparticles within the matrix films. The multimodal upconversion/downshifting CPL behavior enabled cutting-edge encryption applications including optical anticounterfeiting and information encryption. This work introduces a novel approach to designing multimodal upconversion/downshifting CPL materials and opens new avenues for the development of chiroptical functional materials.}, archive = {J_ANGEW}, author = {Bowen Yang and Xuefeng Yang and Yonghong Shi and Xue Jin and Tiesheng Li and Minghua Liu and Pengfei Duan}, doi = {10.1002/anie.202417223}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Upconversion/Downshifting circularly polarized luminescence over 1200 nm in a single nanoparticle for optical anticounterfeiting and information encryption}, volume = {64}, year = {2025}, }
• (2025). Stabilization of ethane-like dianionic diborane(6) in monometallic titanium complexes and its subsequent B(sp3)−B(sp3) bond cleavage. ANGEW, 64(4), e202417170. (www)

  @article{ , abstract = {Treatment of [Cp*TiCl 3 ] with [LiBH 4 ⋅ THF] followed by thermolysis with [Ph 2 E 2 ] (E=S or Se) resulted in the formation of classical diborane(6) complexes, [(Cp*Ti)( η 4 -B 2 H 4 LL′)] (L=C 6 H 4 E; L′=C 6 H 5 E; 1 a : E=S, 1 b : E=Se), stabilized at titanium template. To the best of our knowledge, they are the first examples of mono-metallic classical diborane(6) complexes. The bonding analysis and theoretical studies suggest that the stabilization of these diborane(6) species is due to the presence of four bridging ligands in ĸ 4 -fashion, where two of them are phenyl thiolates/selenolates that provide more electrons to the electron-deficient titanium center. Reactions of these diborane(6) species with [M(CO) 5 ⋅ THF] (M=Mo, W) led to the cleavage of the electron-precise B( sp 3 )−B( sp 3 ) bond that yielded ĸ 3 -hydridoborato complexes [(Cp*Ti)( ĸ 3 -BH 3 R)( μ -EPh) 2 {M(CO) 4 }] ( 2 a – c : R=H, 3 a – c : R=Ph). In an attempt to isolate the Te-analogue of 1 a – b , a similar reaction was performed; however, the complex was too unstable to be isolated. Interestingly, the treatment of this unstable intermediate with [W(CO) 5 ⋅ THF] yielded [(Cp*Ti)( ĸ 3 -BH 3 R)( μ -TePh) 2 {W(CO) 4 }] ( 2 d : R=H, 3 d : R=Ph) that are analogues of 2 a – c and 3 a – c , respectively. Formation of these species provide indirect evidence for the existence of unstable [(Cp*Ti)( η 4 -B 2 H 4 LL′)] (L=C 6 H 4 Te; L′=C 6 H 5 Te; 1 c ).}, archive = {J_ANGEW}, author = {Subhash Bairagi and Soumen Giri and Gaurav Joshi and Eluvathingal D. Jemmis and Sundargopal Ghosh}, doi = {10.1002/anie.202417170}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417170}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilization of ethane-like dianionic diborane(6) in monometallic titanium complexes and its subsequent B(sp3)−B(sp3) bond cleavage}, volume = {64}, year = {2025}, }
• (2025). Sign inversion of circularly polarized luminescence in cholesteric liquid crystals induced by mercury ions through binaphthyl dopants′ conjugation control. ANGEW, 64(4), e202417149. (www)

  @article{ , abstract = {Stimuli-responsive circularly polarized luminescence (CPL) materials based on cholesteric liquid crystal (CLC) platforms show great promise for applications in information encryption and anticounterfeiting. In this study, we constructed a mercury ion-responsive CPL system in CLCs by controlling the conjugation degree of axially chiral binaphthyl derivatives. Two chiral binaphthyl derivatives ( R / S -1 and R / S -2) were initially used as chiral dopants to demonstrate that CPL inversion ( g lum values from 0.5/-0.44 to −0.53/0.48) in CLCs could be achieved by modulating the conjugation degree of the chiral binaphthyls. Based on this concept, the thioacetal binaphthyl R -2S was developed and used as a mercury-responsive chiral dopant in CLCs. Under Hg ion treatment, the CPL sign inverted ( g lum value changed from 0.22 to −0.29) due to the transformation of the thioacetal into an aldehyde group. Additionally, the mercury ion-responsive CPL material was applied in information encryption.}, archive = {J_ANGEW}, author = {Lulu Li and Peiting Jiang and Xueyan Zhang and Yang Li}, doi = {10.1002/anie.202417149}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417149}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sign inversion of circularly polarized luminescence in cholesteric liquid crystals induced by mercury ions through binaphthyl dopants′ conjugation control}, volume = {64}, year = {2025}, }
• (2025). Novel silicate platform as weakly-coordinating anions for diverse organometallic and electrochemical applications. ANGEW, 64(4), e202417136. (www)

  @article{ , abstract = {Weakly-coordinating anions (WCAs) are employed in a wide range of applications, but limitations remain, including high reactivity, limited redox window, complicated synthesis, high cost, low solublity, and low structural tunabililty. Herein, we report a new class of WCA based on alkyl or aryl ( R ) substituted si licates bearing f luorinated pinacolate ligands, “[ R Si F 24 ] − ” . Anions bearing a variety of R groups were prepared, enabling facile tuning of sterics and solubility. A range of cations employed in chemical reactivity has been supported by these anions, including ether-free alkali cations, Ag + , Ph 3 C + , Fc + , [Ni I (COD) 2 ] + . [Pd(dppe)(NCMe)Me] + has been generated by salt metathesis or protonation of a metal-alkyl bond, showcasing the ability of the [ R Si F 24 ] − anions to support applications in coordination chemistry and catalysis. Electrochemical studies on the [Bu 4 N] + variant show an exceptionally wide stability window for the [ Me Si F 24 ] − anion of 7.5 V in MeCN. CV experiments demonstrate reversible Mg deposition and stripping.}, archive = {J_ANGEW}, author = {Tianyi He and Meaghan A. Bruening and Matthew Espinosa and Theodor Agapie}, doi = {10.1002/anie.202417136}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417136}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Novel silicate platform as weakly-coordinating anions for diverse organometallic and electrochemical applications}, volume = {64}, year = {2025}, }
• (2025). A poly(2,7-anthrylene) with peri-fused porphyrin edges. ANGEW, 64(4), e202417129. (www)

  @article{ , abstract = {Anthracene has served as an important building block of conjugated polymers with the connecting positions playing a crucial role for the electronic structures. Herein, anthracene units have been coupled through their 2,7-carbons to develop an unprecedented, conjugated polymer, namely, poly(2,7-anthrylene) featuring additional peri -fused porphyrin edges. The synthesis starts from a 2,7-dibromo-9-nickel(II) porphyrinyl-anthracene as the pivotal precursor. Polymerization is achieved by an AA-type Yamamoto coupling, followed by a polymer-analogous oxidative cyclodehydrogenation to obtain a peri -fusion between porphyrin and anthracene moieties. Although further cyclodehydrogenation between the repeating units cannot be achieved in solution, the thermal treatment of the precursor polymer derived from 2,7-dibromo-9-porphyrinyl-anthracene on a metal surface realizes the full cyclodehydrogenation. The difference between solution and on-surface reactivity can be rationalized by the larger dihedral angle between repeat units in solution, which is reduced under the pronounced interaction with the metal surface. The peri -fusion in the title polymer gives rise to a narrow electronic band gap optical absorptions extending far into the near-infrared region. Oligomeric models are synthesized as well to support the analyses of the electronic and photophysical properties.}, archive = {J_ANGEW}, author = {Yanwei Gu and Feifei Xiang and Yamei Liang and Peizhi Bai and Zijie Qiu and Qiang Chen and Akimitsu Narita and Yinjun Xie and Roman Fasel and Klaus Müllen}, doi = {10.1002/anie.202417129}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417129}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A poly(2,7-anthrylene) with peri-fused porphyrin edges}, volume = {64}, year = {2025}, }
• (2025). Pyrolytic carbon: An inexpensive, robust, and versatile electrode for synthetic organic electrochemistry. ANGEW, 64(4), e202417122. (www)

  @article{ , abstract = {Synthetic organic electrochemistry is recognized as one of the most sustainable forms of redox chemistry that can enable a wide variety of useful transformations. In this study, readily prepared pyrolytic carbon electrodes are explored in several powerful rAP transformations as well as C−C and C−N bond forming reactions. Pyrolytic carbon provides an alternative to classic amorphous carbon-based materials that are either expensive or ill-suited to large-scale flow reactions.}, archive = {J_ANGEW}, author = {Tamara El-Hayek Ewing and Nils Kurig and Yoshio Robert Yamaki and Jiawei Sun and Timothy R. Knowles and Asha Gollapudi and Yu Kawamata and Phil S. Baran}, doi = {10.1002/anie.202417122}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417122}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pyrolytic carbon: An inexpensive, robust, and versatile electrode for synthetic organic electrochemistry}, volume = {64}, year = {2025}, }
• (2025). C−H alkylation of heterocycles via light-mediated palladium catalysis. ANGEW, 64(4), e202417107. (www)

  @article{ , abstract = {Methods enabling direct C−H alkylation of heterocycles are of fundamental importance in the late-stage modification of natural products, bioactive molecules, and medicinally relevant compounds. However, there is a scarcity of a general strategy for the direct C−H alkylation of a variety of heterocycles using commercially available alkyl surrogates. We report an operationally simple palladium-catalyzed direct C−H alkylation of heterocycles using alkyl halides under the visible light irradiation with good scalability and functional group tolerance. Our studies suggest that the photoinduced alkylation proceeds through a cascade of events comprising, site-selective alkyl radical addition, base-assisted deprotonation, and oxidation. A combination of experiments and computations was employed for the generalization of this strategy, which was successfully translated towards the modification of natural products and pharmaceuticals.}, archive = {J_ANGEW}, author = {Sudip Senapati and Sudhir Kumar Hota and Lennard Kloene and Claire Empel and Sandip Murarka and Rene M. Koenigs}, doi = {10.1002/anie.202417107}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417107}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C−H alkylation of heterocycles via light-mediated palladium catalysis}, volume = {64}, year = {2025}, }
• (2025). Constructing Ag/Cu2O interface for efficient neutral CO2 electroreduction to C2H4. ANGEW, 64(4), e202417066. (www)

  @article{ , abstract = {Neutral CO 2 electroreduction to multi-carbons (C 2+ ) offers a promising pathway to reduce the CO 2 and energy losses originating from the carbonate formation. However, the sluggish kinetics of C−C coupling brings a significant challenge of achieving high selectivity of a single product (such as ethylene), especially at industrial-relevant current densities (>300 mA cm −2 ). Here, we reported an optimized Ag-Cu 2 O interfacial catalyst that exhibited C 2+ Faradaic efficiency (FE) of 73.6 % at 650 mA cm −2 in a flow cell. Remarkably, it obtained FE C2H4 of 66.0 % with a partial current density of 429.1 mA cm −2 , making it stand out among the reported Cu-based electrocatalysts. In situ Raman spectra uncovered that the Ag/Cu 2 O interfaces enabled a high coverage of *CO around the partially reduced Cu + /Cu 0 active sites. Furthermore, theoretical calculations demonstrated the enhanced CO formation and C−C coupling at the Ag/Cu 2 O interface. This work reported an unprecedented neutral CO 2 electroreduction to C 2 H 4 performance and provided an in-depth comprehension of the role of the bimetallic interface.}, archive = {J_ANGEW}, author = {Zongnan Wei and Wenwen Wang and Tao Shao and Shuaibing Yang and Chang Liu and Duanhui Si and Rong Cao and Minna Cao}, doi = {10.1002/anie.202417066}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417066}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing Ag/Cu2O interface for efficient neutral CO2 electroreduction to C2H4}, volume = {64}, year = {2025}, }
• (2025). Zipper-like dynamic switching of coordination bonds gives a polar bimetallic halide toward self-driven X-ray detection. ANGEW, 64(4), e202417036. (www)

  @article{ , abstract = {Polar molecular crystals hold a promise for controlling bulk physical properties originated in their unique switchable polarity via structural transformation. However, the mechanisms for switching polarization are mainly limited to displacive and disorder-order phase transitions, which rarely involve the reconstruction of chemical bonds. Here, we have switched and tuned electric polarization in a bimetallic halide, (Neopentylammonium) 4 AgBiBr 8 ( 1 ), as verified by light-excited pyroelectric effect. Most notably, its Ag−Br coordination bonds show a zipper-like dynamic switching behavior from the ‘locked’ to ‘unlocked’ state, namely, reconstruction of chemical bonds. Coupling with the dynamic ordering of organic cations, this bond-switching transition makes a contribution to switchable polarization of 1 . As expected, its polarity creates pyroelectric effect for self-driven X-ray detection with high sensitivity (3.8×10 3 μC Gy −1 cm −2 ) and low limit of detection (4.8 nGy s −1 ). This work on the bond-switching mechanism provides an avenue to design polar molecular candidate for smart optoelectronic devices.}, archive = {J_ANGEW}, author = {Wenjing Li and Yu Ma and Yi Liu and Qingshun Fan and Haojie Xu and Wuqian Guo and Liwei Tang and Hao Rong and Zhihua Sun and Junhua Luo}, doi = {10.1002/anie.202417036}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202417036}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zipper-like dynamic switching of coordination bonds gives a polar bimetallic halide toward self-driven X-ray detection}, volume = {64}, year = {2025}, }
• (2025). Rapid yet controlled synthesis of 2D covalent organic framework nanocapsules as high-performance photocatalytic carriers. ANGEW, 64(4), e202416980. (www)

  @article{ , abstract = {Synthesis and assembly of two-dimensional (2D) polymeric materials present a tricky trade-off between the high reaction rate and precise morphology control. Here we report a nanoconfined synthesis of imine-based 2D covalent organic frameworks (COFs) at the interface of oil-in-water (O/W) emulsion droplets stabilized by cationic surfactants. Highly uniform nanocapsules (NCs) could be prepared without adding extra catalysts at room temperature in just 4.5 h at a yield of 86 %. The NCs have tunable average diameters of 114–565 nm and shell thicknesses of 12–63 nm, depending on the monomer and surfactant types/concentrations. Their BET-specific surface areas are up to 139.0 m 2 /g, mainly contributed by narrowly-distributed mesopores at ~5.0 nm and micropores at 1.4 nm at a volume ratio ( V 1.4 /V 5.0 ) of 1.68. The surfactant plays the role of a catalyst during the reaction and interestingly, it also regulates the formation of mesopores and their sizes. Both theoretical and experimental studies confirm that the reaction has been accelerated by two orders of magnitude at the microdroplet interface, compared to that without emulsification. The resulting NCs could be well dispersed in water for at least six weeks with little size-distribution change, and they have been demonstrated to be highly efficient nanocatalysts in application of water-based hydrogen evolution, reaching a stable hydrogen production rate at 10.2 mmol ⋅ g −1 ⋅ h −1 for 6 hours. Such microdroplet interface-confined synthesis may facilitate the future development of 2D polymeric materials for more advanced applications.}, archive = {J_ANGEW}, author = {Yuting Ma and Shenhui Yu and Wei Li and Di Chen and Zhenqian Zheng and Linjie Mao and Xuan Yang and Wen-Jun Wang and Pingwei Liu}, doi = {10.1002/anie.202416980}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416980}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rapid yet controlled synthesis of 2D covalent organic framework nanocapsules as high-performance photocatalytic carriers}, volume = {64}, year = {2025}, }
• (2025). A photochemical strategy towards michael addition reactions of cyclopropenes. ANGEW, 64(4), e202416956. (www)

  @article{ , abstract = {The development of Michael addition reactions to conjugated cyclopropenes is a challenge in organic synthesis due to the fleeting and reactive nature of such strained Michael acceptor systems. Herein, the development of a photochemical approach towards such conjugated cyclopropenes is reported that serves as a strategic entry point to densely functionalized cyclopropanes in a diastereoselective fashion. The process involves the light-mediated generation of transient cyclopropenyl α,β-unsaturated esters from vinyl diazo esters, followed by an organic base catalyzed nucleophilic addition of N-heterocycles to directly access β-N-heterocyclic cyclopropanoic esters. With this synergistic approach, various trisubstituted cyclopropanes bearing N-heteroaryl and N-heterocyclic rings such as indole, pyrrole, benzimidazole, isatin, pyridinone, and quinolinone were accessed efficiently in good yield and decent to good diastereoselectivities. Further, β-indolyl cyclopropanoic acids have been synthesized and were successfully evaluated as FABP-4 inhibitors. Theoretical calculations have been performed to elucidate the mechanism, which was further supported by experimental findings.}, archive = {J_ANGEW}, author = {Yaseen Hussain and Prasanna R. and Claire Empel and Deepak Sharma and Lennard Kloene and W. Felix Zhu and Astrid Kaiser and Lilia Weizel and Ewgenij Proschak and Rene M. Koenigs and Pankaj Chauhan}, doi = {10.1002/anie.202416956}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416956}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A photochemical strategy towards michael addition reactions of cyclopropenes}, volume = {64}, year = {2025}, }
• (2025). Total synthesis and configuration assignment of (+)-myxoquaterine-450. ANGEW, 64(4), e202416941. (www)

  @article{ , abstract = {Myxoquaterines represent a recently discovered class of natural products with intriguing biological properties. They were isolated from Pendulasporacea albinea MSr 11954 and display a unique structure combining heterocyclic (pyrrole, oxazoline), hexaene, and 2-amino-1,3-diol subunits. We have now synthesized the first example of a myxoquaterine natural product, myxoquaterine-450, in a highly convergent fashion, in which the sensitive hexaene unit was established in the final stages of the synthesis (16 linear steps starting from l -serine). Comparison of the synthetic material with an authentic sample allowed to establish and confirm the constitution and configuration of the natural product.}, archive = {J_ANGEW}, author = {Johanna Löhr and Sabrina Ortmann and Alexander Popoff and Rolf Müller and Thorsten Bach}, doi = {10.1002/anie.202416941}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416941}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis and configuration assignment of (+)-myxoquaterine-450}, volume = {64}, year = {2025}, }
• (2025). [18F]Trifluoroiodomethane – Enabling photoredox-mediated radical [18F]Trifluoromethylation for positron emission tomography. ANGEW, 64(4), e202416901. (www)

  @article{ , abstract = {The development of new tracers for positron emission tomography (PET) is highly dependent on the available synthetic tools for their radiosynthesis. Herein, we present the radiosynthesis and application of [ 18 F]trifluoroiodomethane – the first reagent for broad scope radical [ 18 F]trifluoromethylation chemistry in high molar activity. CF 2 18 FI can be prepared from [ 18 F]fluoroform with 67±5 % AY and >99 % RCP. Its synthetic utility is demonstrated by the radiosynthesis of previously unprecedented 18 F-labeled α-trifluoromethyl ketones and 18 F-labeled trifluoromethyl sulfides, important motifs that are present in a range of bioactive compounds. Both protocols are Ru- and photo-mediated and proceed under mild reaction conditions. They show good functional group tolerance evidenced by the respective reaction scopes and make use of easily obtainable starting materials. The products can be isolated in 8.3–11.1 GBq/μmol (starting from ca. 5 GBq [ 18 F]fluoride). The applicability to PET tracer synthesis is shown by the radiolabeling of bioactive compounds, such as derivatives of probenecid and febuxostat. In a broader context, this work opens the door to the utilization of radical [ 18 F]trifluoromethylation chemistry for the radiolabeling of PET tracers in high molar activity.}, archive = {J_ANGEW}, author = {Lukas Veth and Albert D. Windhorst and Danielle J. Vugts}, doi = {10.1002/anie.202416901}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {[18F]Trifluoroiodomethane – Enabling photoredox-mediated radical [18F]Trifluoromethylation for positron emission tomography}, volume = {64}, year = {2025}, }
• (2025). Highly dispersed ZnO sites in a ZnO/ZrO2 catalyst promote carbon dioxide-to-methanol conversion. ANGEW, 64(4), e202416899. (www)

  @article{ , abstract = {ZnO/ZrO 2 catalysts have shown better activity in the CO 2 hydrogenation to methanol compared with single component counterparts, but the interaction between ZnO and ZrO 2 is still poorly understood. In particular, the effect of the ZrO 2 support phase (tetragonal vs. monoclinic) was not systematically explored. Here, we have synthesized ZnO/ZrO 2 catalysts supported on tetragonal ZrO 2 (ZnO/ZrO 2 -t) and monoclinic ZrO 2 (ZnO/ZrO 2 -m), which resulted in the formation of different ZnO x species, consisting of sub-nanometer ZnO moieties and large-sized ZnO particles, respectively. ZnO/ZrO 2 -t exhibited a higher methanol selectivity (81 vs. 39 %) and methanol yield (1.25 vs. 0.67 mmol g −1 h −1 ) compared with ZnO/ZrO 2 -m. The difference in performance was attributed to the redox state and degree of dispersion of Zn, based on spectroscopy and microscopy results. ZnO/ZrO 2 -t had a high density of ZnO x -ZrO y sites, which favored the formation of active HCOO* species and enhanced the yield and selectivity of methanol along the formate pathway. Such ZnO clusters were further dispersed on ZrO 2 -t during catalysis, while larger ZnO particles on ZnO/ZrO 2 -m remained stable throughout the reaction. This study shows that the phase of ZrO 2 supports can be used to control the dispersion of ZnO and the catalyst surface chemistry, and lead to enhanced catalytic performance.}, archive = {J_ANGEW}, author = {Xibo Zhang and Xiang Yu and Rafael G. Mendes and Peter Matvija and Angela E. M. Melcherts and Chunning Sun and Xinwei Ye and Bert M. Weckhuysen and Matteo Monai}, doi = {10.1002/anie.202416899}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416899}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly dispersed ZnO sites in a ZnO/ZrO2 catalyst promote carbon dioxide-to-methanol conversion}, volume = {64}, year = {2025}, }
• (2025). NIR-II anti-stokes luminescence nanocrystals with 1710 nm excitation for in vivo bioimaging. ANGEW, 64(4), e202416893. (www)

  @article{ , abstract = {Anti-Stokes luminescence (ASL) based on lanthanide nanocrystals holds immense promise for in vivo optical imaging and bio-detection, which benefits from filtered autofluorescence. However, the current longest emission and excitation wavelengths of lanthanide ASL system were shorter than 1200 nm and 1532 nm, respectively, which limited tissue penetration depth and caused low signal-to-noise ratio (SNR) of in vivo imaging due to tissue scattering and water absorption. In this work, we extended the excitation wavelength to 1710 nm with the second near-infrared (NIR-II, 1000–1700 nm) emission up to 1650 nm through a novel ASL nanocrystal LiYF 4 : 10 %Tm@LiYF 4 : 70 %Er@LiYF 4 . Compared with 1532 nm excited ASL nanoprobes, the 1710 nm excited nanocrystals could improve in vivo imaging SNR by 12.72 folds. Based on this excellent imaging performance of the proposed ASL nanoprobes, three-channel in vivo dynamic multiplexed imaging was achieved, which quantitatively revealed metabolic rates of intestinal dynamics and liver enrichment under anesthetized and awake states. This innovative ASL nanoprobes and dynamic multiplexed imaging technology would be conducive to optimizing dosing regimen and treatment plans across various physiological conditions.}, archive = {J_ANGEW}, author = {Zi-Han Chen and Baofeng Yun and Yanran Hou and Xiaohan Wang and Xusheng Wang and Jing Xu and Li Jiang and Ting Han and Hongxin Zhang and Fan Zhang}, doi = {10.1002/anie.202416893}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NIR-II anti-stokes luminescence nanocrystals with 1710 nm excitation for in vivo bioimaging}, volume = {64}, year = {2025}, }
• (2025). Removal of residual additive enabling perfect crystallization of photovoltaic perovskites. ANGEW, 64(4), e202416887. (www)

  @article{ , abstract = {Achieving high-efficiency perovskite solar cells (PSCs) hinges on the precise control of the perovskite film crystallization process, often improved by the inclusion of additives. While dimethyl sulfoxide (DMSO) is traditionally used to manage this process, its removal from the films is problematic. In this work, methyl phenyl sulfoxide (MPSO) was employed instead of DMSO to slow the crystallization rate, as MPSO is more easily removed from the perovskite structure. The electron delocalization associated with the benzene ring in MPSO decreases the electron density around the oxygen atom in the sulfoxide group, thus reducing its interaction with PbI 2 . This strategy not only sustains the formation of a crystallization-slowing intermediate phase but also simplifies the elimination of the additive. Consequently, the optimized PSCs achieved a leading power conversion efficiency (PCE) of 25.95 % along with exceptional stability. This strategy provides a novel method for fine-tuning perovskite crystallization to enhance the overall performance of photovoltaic devices.}, archive = {J_ANGEW}, author = {Ze-Kai Bian and Zhenhuang Su and Yan-Hui Lou and Jing Chen and Run-Jun Jin and Chun-Hao Chen and Yu Xia and Lei Huang and Kai-Li Wang and Xingyu Gao and Zhao-Kui Wang}, doi = {10.1002/anie.202416887}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416887}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Removal of residual additive enabling perfect crystallization of photovoltaic perovskites}, volume = {64}, year = {2025}, }
• (2025). Hydroxyl radical mediated heterogeneous photocatalytic Baeyer–Villiger oxidation over covalent Triazine/Heptazine-based frameworks. ANGEW, 64(4), e202416879. (www)

  @article{ , abstract = {The Baeyer–Villiger (B–V) oxidation of ketones to the corresponding lactones/esters is a classic and essential reaction in the chemical industry. However, this oxidation process has not yet been achieved in ambient conditions with the aid of oxygen and heterogeneous photocatalysts. In this study, we developed an organic photocatalytic system using covalent triazine/heptazine-based frameworks (CTF-TB/CHF-TB) to enable the B–V oxidation reaction under mild conditions through a cascade reaction pathway. Experimental data and theoretical calculations showed that heptazine/triazine units can “chelate” and decompose the in situ generated H 2 O 2 into hydroxyl radicals (⋅OH). Compared to conventional methods that primarily involve metal-activated benzaldehyde at elevated temperatures (e.g., 60 °C), the ⋅OH generated in our study can readily cleave the C−H bond of benzaldehyde, forming an active intermediate that drives subsequent sequential processes: O 2 →H 2 O 2 →⋅OH→Ph-CO⋅→Ph-COOO⋅. By employing this photocatalytic process, a yield of 91 % and a selectivity of over 99 % were obtained in the oxidation of cyclohexanone to caprolactone at room temperature. This performance is comparable to the state-of-the-art catalysts, and our CHF-TB catalyst demonstrates impressive reusability, maintaining a high yield after 5 consecutive runs. This work presents a straightforward approach for C−H cleavage by organocatalysts to produce ϵ -caprolactone in a mild manner by B–V oxidation.}, archive = {J_ANGEW}, author = {Juntao Tang and Zhiwei Jiang and Zhu Gao and Qiujian Xie and Shuai Gu and Anqi Chen and Jiayin Yuan and Wen Li and Ruiren Tang and Guipeng Yu}, doi = {10.1002/anie.202416879}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416879}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydroxyl radical mediated heterogeneous photocatalytic Baeyer–Villiger oxidation over covalent Triazine/Heptazine-based frameworks}, volume = {64}, year = {2025}, }
• (2025). Amorphous nanobelts for efficient electrocatalytic ammonia production. ANGEW, 64(4), e202416878. (www)

  @article{ , abstract = {One-dimensional (1D) amorphous nanomaterials combine the advantages of high active site concentration of amorphous structure, high specific surface area and efficient charge transfer of 1D materials, so they present promising opportunities for catalysis. However, how to achievie the balance between the high orientation of 1D morphology and the isotropy of amorphous structure is a significant challenge, which severely obstructs the controllable preparation of 1D amorphous materials. Guided by the hard-soft acids-bases theory, here we develop a general strategy for preparing 1D amorphous nanomaterials through the precise modulation of bond strength between metal ions and organic ligands for a moderated fastness. The soft base dodecanethiol (DT) is multifunctionally served as both structure-regulating agent and morphology-directing agent. Compared with the borderline acids (e.g. Fe 2+ , Co 2+ , Ni 2+ ) to construct amorphous structure, soft acid of Cu + which produced crystalline nanobelts can still be amorphized by reducing the hardness of Cu ions through redox reaction to weak Cu−SR bond. Due to the combined advantages of amorphous structure and one-dimensional morphology, amorphous CuDT nanobelts exhibited excellent electrocatalytic activity in electrochemical nitrate reduction, outperformed most of the reported Cu-based catalysts. This work will effectively bridge the gap between traditional 1D crystalline nanomaterials synthesis and their amorphization preparation.}, archive = {J_ANGEW}, author = {Ziming Su and Xiangyu Chen and Mingke Sun and Xiuyi Yang and Jianxin Kang and Zhi Cai and Lin Guo}, doi = {10.1002/anie.202416878}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416878}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amorphous nanobelts for efficient electrocatalytic ammonia production}, volume = {64}, year = {2025}, }
• (2025). Rational design of an activatable near-infrared fluorogenic platform for in vivo orthotopic tumor imaging and resection. ANGEW, 64(4), e202416877. (www)

  @article{ , abstract = {Rational and effective design of a universal near-infrared (NIR) light-absorbed platform employed to prepare diverse activatable NIR fluorogenic probes for in vivo imaging and the imaging-guided tumor resection remains less exploited but highly meaningful. Herein, mandelic acid with a core structure of 4-hydroxylbenzyl alcohol to link recognition unit, a fluorophore and a quencher was employed to prepare activatable probes. We exemplified ester as carboxylesterase (CE)-recognized unit, ferrocene as quencher and phenothiazinium as NIR fluorophore to afford fluorogenic probes termed NBS-Fe-CE and NBS-C-Fe-CE . These probes enabled the conversion toward CE with significant fluorescence increases and successfully discriminate CE activity in cells. NIR light enhances the tumor penetration and enable imaging-guided orthotopic tumor resection. This specific case demonstrated that this platform can be effectively used to construct diverse NIR probes for imaging analytes in biological systems.}, archive = {J_ANGEW}, author = {Xiaofeng Wu and Yu Deng and Rui Wang and Heejeong Kim and Gyoungmi Kim and Ying Xu and Kyung Tae Hong and Jun-Seok Lee and Jing-Jing Hu and Gaolin Liang and Juyoung Yoon}, doi = {10.1002/anie.202416877}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416877}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design of an activatable near-infrared fluorogenic platform for in vivo orthotopic tumor imaging and resection}, volume = {64}, year = {2025}, }
• (2025). Sequence-defined synthesis enabled by fast and living anionic monoaddition of vinyl monomers. ANGEW, 64(4), e202416875. (www)

  @article{ , abstract = {The selective monoaddition of polymerizable vinyl monomers like styrenes and methacrylates in a living manner has been achieved for the flash-flow preparation of molecules in a defined sequence with high selectivity. We demonstrated the sequence-defined synthesis of multifunctional molecules using an initiator, functionalized styrenes, diarylethylenes, various methacrylates, and an electrophilic trapping reagent at the living terminus (six-component sequential connection at maximum) without any intermediate purification steps. The anionic living terminus of the vinyl monomers in the flow system described herein is active for polymerization, such that the styrene or methacrylate sequence can be expanded to afford highly dispersed oligomers without affecting other single units, which means that the unequivocal sequences were successfully inserted into the internal or terminal positions. The methodology described herein provides an adaptable method for the construction of new molecular spaces based on unimolecular sequence control and pinpoint functionalization.}, archive = {J_ANGEW}, author = {Kazuhiro Okamoto and Dong-eun Yoo and Rikako Yoshioka and Ryohei Nakasato and Yosuke Ashikari and Kenji Kitayama and Aiichiro Nagaki}, doi = {10.1002/anie.202416875}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416875}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sequence-defined synthesis enabled by fast and living anionic monoaddition of vinyl monomers}, volume = {64}, year = {2025}, }
• (2025). High-potential and stable organic cathode for rechargeable batteries with fast-charging and wide-temperature adaptability. ANGEW, 64(4), e202416874. (www)

  @article{ , abstract = {Organic carbonyl compounds have been recognized as promising electrodes due to multiple active sites, abundant element resources and flexible structural designability, while their practical applications are still hindered by the easy solubility and low discharge potential. Herein, a novel bipolar polymer composite (TAC) was well-designed by grafting p-type triphenylamine units onto n-type anthraquinone to form an extended π-conjugated structure and in situ growing on carbon nanotubes, which was proved not only with higher discharge potential but also effectively suppress the dissolution issues. Moreover, TAC combined the advantages of different active sites and behaved a dual-ion storage mechanism. Benefitting from the in situ polymerization process, TAC with tube-type core–shell structure exhibited enhanced electron transport and improved utilization of active sites, resulting in high capacity (193 mAh g −1 ), outstanding rate performance (fast charging within 17 s), long-term stability (a high capacity retention of 87 % after 1000 cycles) and high mass loading (10 mg cm −2 ). Additionally, TAC can well adapt to the temperature change, outputting a capacity of 72 mAh g −1 at −60 °C and 165 mAh g −1 at 80 °C. Such versatile polymer structure inspires the design of high performance organic materials for rechargeable batteries to satisfy high stability and wide temperature operations.}, archive = {J_ANGEW}, author = {Haotian Wang and Gaopan Liu and Wen Zhou and Yonggang Wang and Xiaoli Dong}, doi = {10.1002/anie.202416874}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416874}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-potential and stable organic cathode for rechargeable batteries with fast-charging and wide-temperature adaptability}, volume = {64}, year = {2025}, }
• (2025). Catalytic asymmetric synthesis of inherently chiral eight-membered O-heterocycles through cross-[4+4] cycloaddition of quinone methides. ANGEW, 64(4), e202416873. (www)

  @article{ , abstract = {Inherently chiral eight-membered rings embedded in tetraphenylene derivatives and hetero-analogues exhibit unique properties and allow diverse applications. A conceptually viable and straightforward approach to these frameworks is [4+4] cycloaddition, which still remains elusive. Herein, we describe the stereoselective cross-[4+4] cycloaddition of quinone methides (QMs), leading to the formation of oxa-analogues of tetraphenylene with exceptional chemo-, diastereo-, and enantioselectivity. The structures of these novel rigid eight-membered O-heterocycles were explored by single-crystal X-ray diffraction, and their stereochemical stability was elaborated through both density functional theory (DFT) calculations and thermal racemization experiments. The developed methodology exhibited broad substrate scope and the resulting cross-[4+4] cycloadducts could be readily transformed into valuable chiral building blocks. Our findings expand the library of inherently chiral medium-sized rings and also contribute to the advancement of asymmetric cross-[4+4] cycloadditions of quinone methides.}, archive = {J_ANGEW}, author = {Da Xu and Guojie Zhou and Bangli Liu and Shiqi Jia and Yidong Liu and Hailong Yan}, doi = {10.1002/anie.202416873}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416873}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic asymmetric synthesis of inherently chiral eight-membered O-heterocycles through cross-[4+4] cycloaddition of quinone methides}, volume = {64}, year = {2025}, }
• (2025). Efficient water reforming of biomass to h2 via well-organized redox-neutral cleavage of C−C, O−H and C−H bonds. ANGEW, 64(4), e202416867. (www)

  @article{ , abstract = {Hydrogen (H 2 ) is a clean and environmentally friendly energy carrier. The depletion of fossil fuels makes renewable H 2 production highly desirable. Water reforming of renewable biomass to hydrogen, with a relay of natural photosynthesis to biomass, would be an indirect pathway to realize the ideal but extremely challenging photocatalytic overall water splitting to hydrogen, with favorable thermodynamics. Since the seminal work of water reforming of biomass in 1980, great endeavors have been made. Nevertheless, hitherto, the entire kinetic pathway has been elusive, which seriously limits the reforming processes. Using a designed well-organized redox-neutral cleavage of C−C, O−H and C−H bonds enabled by photoelectrocatalysis, here, we show the efficient water reforming of biomass to hydrogen at room temperature, with a yield up to 93 %. The clear insights into the kinetic pathway with oxidation of carbon radicals to carbon cations as the indicated rate-determining step, would cast brightness for efficient and sustainable hydrogen production to accelerate the hydrogen economy.}, archive = {J_ANGEW}, author = {Wen-Min Zhang and Yang Li}, doi = {10.1002/anie.202416867}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416867}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient water reforming of biomass to h2 via well-organized redox-neutral cleavage of C−C, O−H and C−H bonds}, volume = {64}, year = {2025}, }
• (2025). Ethanol processable inorganic-organic hybrid hole transporting layers enabled 20.12 % efficiency organic solar cells. ANGEW, 64(4), e202416866. (www)

  @article{ , abstract = {In this study, a high-performance inorganic-organic hybrid hole transporting layer (HTL) was developed using ethanol-soluble alkoxide precursors and a self-assembled monolayer (SAM). Three metal oxides-vanadium oxide (VO x ), niobium oxide (Nb 2 O 5 ), and tantalum oxide (Ta 2 O 5 )-were synthesized through successive low-temperature (100 °C) thermal annealing (TA) and UV-ozone (UVO) treatments of their respective precursors: vanadium oxytriethoxide (EtO−V), niobium ethoxide (EtO−Nb), and tantalum ethoxide (EtO−Ta). Among these, the Nb 2 O 5 film exhibited excellent transmittance, a high work function, and good conductivity, along with a more compact and uniform structure featuring fewer interfacial defects, which facilitated efficient charge extraction and transport. Furthermore, the deposition of a SAM of (2-(9H-carbazol-9-yl)ethyl)phosphonic acid (2PACz) on top of Nb 2 O 5 further passivated defects, enhancing interfacial contact with the photoactive layer. The resulting inorganic-organic hybrid HTL of Nb 2 O 5 /2PACz demonstrated excellent compatibility with various photoactive blends, achieving impressive power conversion efficiencies of 19.44 %, 19.18 %, and 20.12 % for the PM6:L8-BO, PM6:BTP-eC9, and D18:BTP-eC9 based organic solar cells, respectively. 20.12 % is the best performance for bulk heterojunction organic solar cells with binary components as the photoactive layer.}, archive = {J_ANGEW}, author = {Hongjia Li and Yinfeng Li and Xingjian Dai and Xiaopeng Xu and Qiang Peng}, doi = {10.1002/anie.202416866}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416866}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ethanol processable inorganic-organic hybrid hole transporting layers enabled 20.12 % efficiency organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Molecular weaving towards flexible covalent organic framework membranes for efficient gas separations. ANGEW, 64(4), e202416864. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) exhibit considerable potential in gas separations owing to their remarkable stability and tunable pore structures. Nevertheless, their application as gas separation membranes is hindered by limited size-sieving capabilities and poor processability. In this study, we propose a novel molecular weaving strategy that combines hydroxyl polymers and 2D TpPa−SO 3 H COF nanosheets, achieving high gas separation efficiency. Driven by the strong electrostatic interactions, the hydroxyl chains thread through the COF pores, effectively weaving and assembling the composites to achieve exceptional flexibility and high mechanical strength. The penetrated chains also reduce the effective pore size of COFs, and combined with the “secondary confinement effect” stemming from abundant CO 2 sorption sites in the channels, the PVA@TpPa−SO 3 H membrane demonstrates a remarkable H 2 permeance of 1267.3 GPU and an H 2 /CO 2 selectivity of 43, surpassing the 2008 Robson upper bound limit. This facile strategy holds promise for the manufacture of large-area COF-based membranes for small-sized gas separations.}, archive = {J_ANGEW}, author = {Xiaohe Tian and Li Cao and Keming Zhang and Rui Zhang and Xueqin Li and Chongshan Yin and Shaofei Wang}, doi = {10.1002/anie.202416864}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular weaving towards flexible covalent organic framework membranes for efficient gas separations}, volume = {64}, year = {2025}, }
• (2025). Chiral co-assembly based on a stimuli-responsive polymer towards amplified full-color circularly polarized luminescence. ANGEW, 64(4), e202416863. (www)

  @article{ , abstract = {Stimuli-responsive circularly polarized luminescence (CPL) materials have been attaching wide attention in the field of optical information storage and encryption, while still facing the challenge of the realization of high luminescence dissymmetry factors ( g lum ). This work presents a pair of stimuli-responsive chiral co-assemblies P7R3 and P7S3 by combining polymer PFIQ containing iso -quinoline units with chiral inducers. The obtained chiral co-assemblies can reversibly undergo significant modification in CPL behavior under trifluoroacetic acid (TFA) fumigation and annealing treatment, with the |g lum | values exhibiting a reversible shift between 0.2 and 0.3. Moreover, the chiral co-assemblies before TFA fumigating can effectively induce achiral emitters to generate intense full-color CPL signals through CPL energy transfer (CPL-ET), with the corresponding | g lum | values larger than 0.2. Moreover, information encryption and decryption as well as a multi-level logic gates application are achieved by leveraging the reversible stimuli-responsive CPL activity of the chiral co-assembly. This work provides a new perspective for the construction of stimuli-responsive chiral luminescent materials with large | g lum | values and the activation of CPL behavior in achiral emitters.}, archive = {J_ANGEW}, author = {Wen-Long Zhao and Wei-Chen Guo and Ke.-Ke Tan and Zhen-Xing Yu and Meng Li and Chuan-Feng Chen}, doi = {10.1002/anie.202416863}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416863}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral co-assembly based on a stimuli-responsive polymer towards amplified full-color circularly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Low-temperature flexibility of chiral organic crystals with highly efficient second-harmonic generation. ANGEW, 64(4), e202416856. (www)

  @article{ , abstract = {Flexible crystals with unique mechanical properties have presented potential for applications in optoelectronics, soft robotics and sensors. However, there have been no reports of low-temperature-resistant flexible crystals with second-order nonlinear optical properties (NLO). Here, we report flexible chiral Schiff-base crystals capable of efficient second harmonic generation (SHG). Both enantiomers and the racemic form of these crystals are mechanically flexible in two directions at both room temperature and at 77 K, although their mechanical responses differ. The enantiomers display SHG with an intensity of up to 12 times that of potassium dihydrogenphosphate (KDP) when pumped at 980 nm, and they also have high laser-induced damage thresholds (LDT). Even when bent, the crystals retain strong second harmonic generation, although with a different intensity distribution depending on the polarization, compared to when they are straight. This work describes the first instance of flexible organic single-crystalline material with NLO properties and lays the foundation for the development of mechanically flexible organic NLO materials.}, archive = {J_ANGEW}, author = {Jiawei Lin and Jianmin Zhou and Zhihua Wang and Liang Li and Maolin Li and Jialiang Xu and Songgu Wu and Panče Naumov and Junbo Gong}, doi = {10.1002/anie.202416856}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416856}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Low-temperature flexibility of chiral organic crystals with highly efficient second-harmonic generation}, volume = {64}, year = {2025}, }
• (2025). Activation and deactivation of chirality transfer in the superbundles of sequence-defined stereoisomers. ANGEW, 64(4), e202416853. (www)

  @article{ , abstract = {Discrete oligomers can be used to precisely evaluate the structure–property relationship and enable unique chiroptical activities, however, the role of stereochemical sequences on chirality transfer is still unclear. Herein, we report the successful synthesis of a series of sequence-defined chiral azobenzene (Azo) oligomers via iterative stepwise chain growth strategy. Sequence-defined stereoisomers with one single chiral ( L or D ) stereocenter at the α-position, ω-position and middle- ( m −) position have completely different self-assembly dynamics. ω-positional stereocenter can effectively command all Azo building blocks to adopt a tilted π–π stacking along the helical superbundles, exhibiting the activation of chirality transfer. However, discrete oligomers with the stereocenter at other positions can only self-assemble into non-helical nanowires, accompanied by the deactivation of chirality transfer.Cooperative supramolecular interactions, including the π–π interaction between Azo units, the intermolecular hydrogen bonding and steric hindrance, are intrinsic driving forces for these differentiations.}, archive = {J_ANGEW}, author = {Zhihong Yu and Rui Tan and Xiaoxiao Cheng and Wei Zhang and Yong Wang and Jiandong Zhang and Nianchen Zhou and Zhengbiao Zhang and Xiulin Zhu}, doi = {10.1002/anie.202416853}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416853}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Activation and deactivation of chirality transfer in the superbundles of sequence-defined stereoisomers}, volume = {64}, year = {2025}, }
• (2025). Dynamically confined active silver nanoclusters with ultrawide operating temperature window in CO oxidation. ANGEW, 64(4), e202416852. (www)

  @article{ , abstract = {Supported metal nanoclusters are often highly active in many catalytic reactions but less stable particularly under harsh reaction conditions. Here, we demonstrate that this activity-stability trade-off can be efficiently broken through rational design of surrounding microenvironment of the supported nanocatalyst including gas adsorbate overlayer and underneath support surface chemistry. Our studies reveal that chemisorbed oxygen species on Ag surface and surface hydroxyl groups on oxide support, which are dynamically consumed during reaction but sustained by reaction environment (O 2 and H 2 O vapor), drive spontaneous redispersion of Ag particles and stabilization of highly active Ag nanoclusters. Such a dynamic confinement effect from gas-catalyst-support interaction enables the Ag nanoclusters to exhibit complete catalytic oxidation of CO over a wide temperature window of 25-500 °C under dry conditions and 200-800 °C under wet conditions as well as remarkable stability at 300 °C over 1000 h.}, archive = {J_ANGEW}, author = {Rongtan Li and Rentao Mu and Kun Li and Yamei Fan and Conghui Liu and Yanxiao Ning and Mingrun Li and Qiang Fu and Xinhe Bao}, doi = {10.1002/anie.202416852}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416852}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamically confined active silver nanoclusters with ultrawide operating temperature window in CO oxidation}, volume = {64}, year = {2025}, }
• (2025). Stable and recyclable copper nanoclusters with exposed active sites for broad-scope protosilylation in open air. ANGEW, 64(4), e202416851. (www)

  @article{ , abstract = {Despite recent advances in cluster-based catalysis for organic synthesis, the substrate scope of reactions catalyzed by metal nanoclusters is typically not superior to previously established catalytic systems. Herein, we develop new atomically precise copper nanoclusters for protosilylation, with scope expanding to alkenes and simple enynes that were not suitable for prior synthetic methodologies with traditional copper complexes. The involvement of a second copper center in the metal kernel during the migratory insertion step is thought to be responsible for the expanded scope. In addition, the reaction is highly compatible with water and can be carried out in open air rather than under inert gas protection. Mechanistic studies suggest that the cluster-catalyzed protosilylation proceeds in the absence of silyl radicals. The current findings demonstrate the potential of using metal nanoclusters for practical and sustainable chemical synthesis.}, archive = {J_ANGEW}, author = {Songwei Wen and Chengkai Zhang and Li-Juan Liu and Zhi Wang and Di Sun and Jian He}, doi = {10.1002/anie.202416851}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416851}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable and recyclable copper nanoclusters with exposed active sites for broad-scope protosilylation in open air}, volume = {64}, year = {2025}, }
• (2025). Coplanar atropochiral 5H-cyclopenta[2,1-b:3,4-b′]dipyridine ligands: Synthesis and applications in asymmetric ring-opening reaction. ANGEW, 64(4), e202416839. (www)

  @article{ , abstract = {Bipyridines represent a class of ligands renowned for their versatility and efficacy in numerous transition metal-catalyzed reactions. Chiral bipyridine ligands are noted for their distinctive reactivity and stereoselectivity. In this work, we have designed and synthesized a class of bipyridine ligands endowed with an axially chiral scaffold. These ligands feature: (a) a precisely aligned coplanar bipyridine framework that is beneficial for metal chelation; (b) a spacious environment around the metal-bipyridine complexes, capable of hosting substrates with substantial steric bulk; (c) a chiral pocket induced by the axially chiral architecture. These atropochiral planar bipyridine ligands were successfully applied in copper-catalyzed ring-opening reactions of cyclic diaryliodoniums with bulky secondary amines, achieving high efficiency and stereoselectivity that were unsuccessful in our previous efforts.}, archive = {J_ANGEW}, author = {Han Yang and Xiaojie Sun and Zhen Chen and Chenming Jiang and Longhui Duan and Jinbo Zhao and Zhenhua Gu}, doi = {10.1002/anie.202416839}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416839}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coplanar atropochiral 5H-cyclopenta[2,1-b:3,4-b′]dipyridine ligands: Synthesis and applications in asymmetric ring-opening reaction}, volume = {64}, year = {2025}, }
• (2025). Dicyclopenta[4,3,2,1-cde:4′,3′,2′,1′-pqr]-peri-tetracene: Synthesis and an example of annulene-within-an-annulene aromaticity in different redox states. ANGEW, 64(4), e202416833. (www)

  @article{ , abstract = {We report a robust strategy for tuning the electronic structure and chemical stability of π-conjugated polycyclic hydrocarbons (PHs). By fusing two cyclopentadienyl rings in the peri -tetracene bay regions, we introduce antiaromatic character into the π-system, leading to unique photophysical and electronic properties. A stable mesityl-substituted dicyclopenta- peri -tetracene derivative was synthesized through stepwise formylation/intramolecular cyclization at the bay regions of the dihydro peri -tetracene precursor, followed by oxidative dehydrogenation. This compound features an open-shell singlet diradical ground state, global antiaromaticity, exceptional stability under ambient conditions, and amphoteric redox behavior with a small energy gap. Its dication also possesses an open-shell singlet ground state, and its structure was identified by X-ray crystallographic analysis, revealing a unique [14]annulene-within-[22]annulene global aromatic structure. In contrast, the dianion exhibits a closed-shell singlet ground state. This work provides valuable insights for designing and synthesizing novel open-shell PHs with tunable electronic structures and remarkable stability.}, archive = {J_ANGEW}, author = {Qing Jiang and Yi Han and Xudong Hou and Shaofei Wu and Tingting Xu and Mesías Orozco-Ic and Gabriel Merino and Chunyan Chi}, doi = {10.1002/anie.202416833}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416833}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dicyclopenta[4,3,2,1-cde:4′,3′,2′,1′-pqr]-peri-tetracene: Synthesis and an example of annulene-within-an-annulene aromaticity in different redox states}, volume = {64}, year = {2025}, }
• (2025). Orderly coating of bilayer polymer to tailor microenvironment for efficient C−N coupling toward highly selective urea electrosynthesis. ANGEW, 64(4), e202416832. (www)

  @article{ , abstract = {Electrosynthesis of urea from co-reduction of carbon dioxide and nitrate is a promising alternative to the industrial process. However, the overwhelming existence of proton and nitrate as well as the insufficient supply of CO 2 at the reaction interface usually result in complex product distributions from individual nitrate reduction or hydrogen evolution, instead of C−N coupling. In this work, we systematically optimize this microenvironment through orderly coating of bilayer polymer to specifically tackle the above challenges. Polymer of intrinsic microporosity is chosen as the upper polymer to achieve physical sieving, realizing low water diffusivity for suppressing hydrogen evolution and high gas permeability for smooth mass transfer of CO 2 at the same time. Polyaniline with abundant basic amino groups is capable of triggering chemical interaction with acidic CO 2 molecules, so that is used as the underlying polymer to serve as CO 2 concentrator and facilitate the carbon source supply for C−N coupling. Within this tailored microenvironment, a maximum urea generation yield rate of 1671.6 μg h −1 mg −1 and a high Faradaic efficiency of 75.3 % are delivered once coupled with efficient electrocatalyst with neighboring active sites, which is among the most efficient system of urea electrosynthesis.}, archive = {J_ANGEW}, author = {Zhichao Wang and Mengfan Wang and Qiyang Cheng and Yanzheng He and Sisi Liu and Jie Liu and Xiaolei Yuan and Yunfei Huan and Tao Qian and Chenglin Yan}, doi = {10.1002/anie.202416832}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416832}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Orderly coating of bilayer polymer to tailor microenvironment for efficient C−N coupling toward highly selective urea electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). NIR-activable charge transfer agents for synergistic photoimmunotherapy. ANGEW, 64(4), e202416828. (www)

  @article{ , abstract = {The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) has become an attractive tumor treatment modality, yet the facile design of photoimmunotheranostic agents with efficient near infrared (NIR) light-absorbing and immune-activating capabilities remains a tremendous challenge. Herein, we developed a NIR-activable organic charge transfer complex (CTC), with perylene (PER) as the electron donor and 4,5,9,10-tetrabromoisochromeno [6,5,4-def]isochromene-1,3,6,8-tetraone (Br4NDI) as the electron acceptor. Through further supramolecular assembly, the PER-Br4NDI nanoparticle (PBND NP) for spatiotemporally controlled photoimmunotherapy was constructed. The PBND NP exhibits superb NIR absorption, robust intermolecular charge transfer, and enhanced intersystem crossing. Upon NIR photoirradiation, the PBND NP effectively exerts photothermal and photodynamic effects with a remarkable photothermal conversion efficiency of 63.5 % and a high reactive oxygen species generation capability, which not only directly ablates primary tumors, but also dramatically suppresses distant tumor growth via promoted immunogenic cell death. Moreover, programmed cell death protein 1 antibody acts synergistically to block immune evasion and ultimately enhances cancer treatment efficacy. This work therefore sheds light on the design of organic CTCs for synergistic photoimmunotherapy.}, archive = {J_ANGEW}, author = {Chu Wang and Wenbin Zhong and Xiaohuan Sun and Jingjing Guo and Yun Chen and Yue Zhao and Jie Han and Yanli Zhao}, doi = {10.1002/anie.202416828}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416828}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NIR-activable charge transfer agents for synergistic photoimmunotherapy}, volume = {64}, year = {2025}, }
• (2025). Localized water restriction in ternary eutectic electrolytes for ultra-low temperature hydrogen batteries. ANGEW, 64(4), e202416800. (www)

  @article{ , abstract = {Proton batteries are promising candidates for next-generation large-scale energy storage in extreme conditions due to the small ionic radius and efficient transport of protons. Hydrogen gas, with its low working potentials, fast kinetics, and stability, further enhances the performance of proton batteries but necessitates the development of novel electrolytes with low freezing points and reduced corrosion. This work introduces a localized water restriction strategy by incorporating a tertiary component with a high donor number, which forms strong bonds with water molecules. This approach restricts free water molecules and reduces the average hydrogen bond ratio and strength. As-prepared ternary eutectic electrolytes lowered the freezing point to −103 °C, significantly lower than the traditional binary electrolyte (9.5 m H 3 PO 4 , −93 °C). This electrolyte is highly compatible with the Cu 0.79 Co 0.21 [Fe(CN) 6 ] 0.64 ⋅ 4H 2 O (CoCuHCF) cathode, reducing material dissolution and current collector corrosion. The H 2 ||CoCuHCF battery using this electrolyte demonstrated a high-power density of 23664.3 W kg −1 , excellent performance at −80 °C, and stable cyclability over 1000 cycles (>30 days) at −50 °C. These findings provide a framework for proton electrolytes, highlighting the potential of hydrogen batteries in challenging environments.}, archive = {J_ANGEW}, author = {Ziyue Li and Yuxiao Lin and Jiafeng Ruan and Mochou Liao and Fengmei Wang and Ruohan Jiang and Xuelian Qu and Qin Li and Jinyu Yang and Xinjie Li and Zihao Zhang and Yunsong Li and Dalin Sun and Fang Fang and Fei Wang}, doi = {10.1002/anie.202416800}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416800}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Localized water restriction in ternary eutectic electrolytes for ultra-low temperature hydrogen batteries}, volume = {64}, year = {2025}, }
• (2025). Biosynthesis of (−)-vinigrol. ANGEW, 64(4), e202416795. (www)

  @article{ , abstract = {(−)-Vinigrol is one of the most complex and challenging molecules in total synthesis; however, the parallel biosynthetic strategy employed by nature for the synthesis of this compound has not yet been identified. In this study, we identified a minimal gene cluster encoding a diterpene cyclase (VniA) and a cytochrome P450 (VniB) which enables the synthesis of (−)-vinigrol through three steps. VniA first cyclizes geranylgeranyl diphosphate to generate an unusual vinigrol-type diterpene skeleton, and then VniB catalyzes the allylic C(sp 3 )−H iterative oxidation. Further genome mining investigation provides new fungal sources for this rare and valuable vinigrol-type diterpene skeleton.}, archive = {J_ANGEW}, author = {Run Xu and Yi Zou}, doi = {10.1002/anie.202416795}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416795}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biosynthesis of (−)-vinigrol}, volume = {64}, year = {2025}, }
• (2025). Energy dissipation and toughening of covalent networks via a sacrificial conformation approach. ANGEW, 64(4), e202416790. (www)

  @article{ , abstract = {Covalent polymer networks find wide utility in diverse engineering applications owing to their desirable stiffness and resilience. However, the rigid covalent chemical structure between crosslinking points imposes limitations on enhancing their toughness. Although the incorporation of sacrificial chemical bonds has shown promise in improving toughness through energy dissipation, composite networks struggle to maintain both rapid recovery and stiffness. Consequently, a significant challenge persists in achieving a covalent network that combines high strength, stiffness, toughness, and fast recovery performance. To address this challenge, we propose a novel sacrificial structure termed “sacrificial conformation.” In this approach, β-cyclodextrin is covalently embedded into the network skeleton as the sacrificial conformation element. Compared to traditional covalent networks (LCN), well-designed cyclodextrin-embedded covalent network (CCN) exhibit a 100-fold increase in Young's modulus and a 60-fold increase in toughness. Importantly, CCN maintains excellent elasticity, ensuring swift recovery after deformation. This sacrificial conformational strategy enables efficient energy dissipation without necessitating the rupture of chemical bonds, thereby overcoming the limitations of traditional approaches. This advancement holds great promise for the design and fabrication of advanced elastomers and hydrogels with superior mechanical properties and dynamic behavior.}, archive = {J_ANGEW}, author = {Hao Wang and Zhiyou Wei and Zhiwei Liu and Bin Zheng and Zhaoming Zhang and Xuzhou Yan and Linli He and Tao Li and Dong Zhao}, doi = {10.1002/anie.202416790}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Energy dissipation and toughening of covalent networks via a sacrificial conformation approach}, volume = {64}, year = {2025}, }
• (2025). Stereoselective radical acylfluoroalkylation of bicyclobutanes via N-heterocyclic carbene catalysis. ANGEW, 64(4), e202416781. (www)

  @article{ , abstract = {Cyclobutanes are prominent structural components in natural products and drug molecules. With the advent of strain-release-driven synthesis, ring-opening reactions of bicyclo[1.1.0]butanes (BCBs) provide an attractive pathway to construct these three-dimensional structures. However, the stereoselective difunctionalization of the central C−C σ-bonds remains challenging. Reported herein is a covalent-based organocatalytic strategy that exploits radical NHC catalysis to achieve diastereoselective acylfluoroalkylation of BCBs under mild conditions. The Breslow enolate acts as a single electron donor and provides an NHC-bound ketyl radical with appropriate steric hindrance, which effectively distinguishes between the two faces of transient cyclobutyl radicals. This operationally simple method tolerates various fluoroalkyl reagents and common functional groups, providing a straightforward access to polysubstituted cyclobutanes (75 examples, up to >19 : 1 d.r.). The combined experimental and theoretical investigations of this organocatalytic system confirm the formation of the NHC-derived radical and provide an understanding of how stereoselective radical-radical coupling occurs.}, archive = {J_ANGEW}, author = {Chuyu Xiao and Jing-Ran Shan and Wen-Deng Liu and Xingyuan Gao and Jingwei Dai and Zuwei Wang and Wentao Wang and K. N. Houk and Jiannan Zhao}, doi = {10.1002/anie.202416781}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416781}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereoselective radical acylfluoroalkylation of bicyclobutanes via N-heterocyclic carbene catalysis}, volume = {64}, year = {2025}, }
• (2025). Vertically expanded covalent organic frameworks for photocatalytic water oxidation into oxygen. ANGEW, 64(4), e202416771. (www)

  @article{ , abstract = {Covalent organic frameworks with unique π architectures and pores could be developed as photocatalysts for transformations. However, they usually form π-stacking layers, so that only surface layers function in photocatalysis. Here we report a strategy for developing vertically expanded frameworks to expose originally inaccessible active sites hidden in layers to catalysis. We designed covalently linked two-dimensional cobalt(II) porphyrin layers and explored coordination bonds to connect the cobalt(II) porphyrin layers with bidentate ligands via a three-component one-pot polymerization. The resultant frameworks expand the interlayer space greatly, where both the up and down faces of each cobalt(II) porphyrin layer are exposed to reactants. Unexpectedly, the vertically expanded frameworks increase skeleton oxidation potentials, decrease exciton dissociation energy, improve pore hydrophilicity and affinity to water, and facilitate water delivery. Remarkably, these positive effects work collectively in the photocatalysis of water oxidation into oxygen, with an oxygen production rate of 1155 μmol g −1 h −1 , a quantum efficiency of 1.24 % at 450 nm, and a turnover frequency of 1.39 h −1 , which is even 5.1-fold as high as that of the π-stacked frameworks and ranks them the most effective photocatalysts. This strategy offers a new platform for designing layer frameworks to build various catalytic systems for chemical transformations.}, archive = {J_ANGEW}, author = {Shuailei Xie and Ruoyang Liu and Nengyi Liu and Hetao Xu and Xiong Chen and Xinchen Wang and Donglin Jiang}, doi = {10.1002/anie.202416771}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416771}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vertically expanded covalent organic frameworks for photocatalytic water oxidation into oxygen}, volume = {64}, year = {2025}, }
• (2025). Increasing the donor strength of alkenylphosphines by twisting the C=C double bond. ANGEW, 64(4), e202416764. (www)

  @article{ , abstract = {Electron-rich phosphines play a crucial role in transition metal-based homogeneous catalysis. While alkyl groups have traditionally been employed to increase the phosphine donor strength, recent studies have shown that zwitterionic functional groups such as phosphorus ylides can result in a further enhancement. Herein we report the concept of twisting a C=C double bond to introduce a zwitterionic substituent by the synthesis and application of N-heterocyclic olefin phosphines with a sulfonyl substituent (sNHOP). This sulfonyl group enables the twisting of the olefin moiety due to steric and electronic stabilization of the carbanionic center. The resulting zwitterionic structure leads to a significant increase of the donor strength of the sNHOP ligands compared to conventional NHOP systems with a planar N-heterocyclic olefin moiety. The potential of this new ligand platform for catalysis is demonstrated by its application in the gold-catalyzed hydroamination and cyclo-isomerization of alkynes. Here, the ligands outperform the original NHOP ligands suggesting favorable properties for future catalysis applications.}, archive = {J_ANGEW}, author = {Cheng-Han Yu and Yu-Wen Hsiao and Julian Löffler and Nicolas Kaiser and Bo-Hong Huang and Chao-Hsien Lee and Chen-Hsun Hung and Jiun-Shian Shen and Glenn P. A. Yap and Viktoria H. Gessner and Tiow-Gan Ong}, doi = {10.1002/anie.202416764}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416764}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Increasing the donor strength of alkenylphosphines by twisting the C=C double bond}, volume = {64}, year = {2025}, }
• (2025). Enhanced adsorption kinetics and capacity of a stable CeF3@Ni3N heterostructure for methanol electro-reforming coupled with hydrogen production. ANGEW, 64(4), e202416763. (www)

  @article{ , abstract = {Alkaline methanol-water electrolysis system is regarded as an appealing strategy for electro-reforming methanol into formate and producing hydrogen with low energy-consumption compared with alkaline water electrolysis. However, stability and selectivity under high current densities for practical application remain challenging. Herein, a CeF 3 @Ni 3 N nanosheets array anchored on carbon cloth (CeF 3 @Ni 3 N/CC) was fabricated. The gradual extrusion of F species from Ni(OH) 2 lattices can stabilize hierarchical structure and construct abundant heterostructure interfaces. Moreover, CeF 3 can modulate electron distribution of Ni 3 N, thus simultaneously enhancing the surface adsorption kinetics and capability of methanol and OH − , which is conducive to enhanced methanol oxidation reaction (MOR) activity and selectivity. Therefore, bifunctional CeF 3 @Ni 3 N/CC exhibits low potential of 1.43 V at 500 mA cm −2 , along with high stability over 72 h and high faradaic efficiency (FEs) in MOR, as well as an overpotential of 76 mV to achieve 50 mA cm −2 for hydrogen evolution reaction (HER). Furthermore, membrane-free CeF 3 @Ni 3 N/CC||CeF 3 @Ni 3 N/CC cell for MOR||HER delivers high electrocatalytic activity, long-term stability and FEs at high current density of 300 mA cm −2 . This study highlights the importance of optimizing surface adsorption behavior of active species, as well as rational design of highly efficient heterostructure electrocatalysts for methanol upgrading coupled with hydrogen production.}, archive = {J_ANGEW}, author = {Kuan Deng and Xuesong Liu and Peng Liu and Xingbin Lv and Wen Tian and Junyi Ji}, doi = {10.1002/anie.202416763}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416763}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced adsorption kinetics and capacity of a stable CeF3@Ni3N heterostructure for methanol electro-reforming coupled with hydrogen production}, volume = {64}, year = {2025}, }
• (2025). Reducing dead species by electrochemically-densified cathode-interface-reaction layer towards high-rate-endurable Zn||I-br batteries. ANGEW, 64(4), e202416755. (www)

  @article{ , abstract = {Interhalogen-involved aqueous Zn||halogen batteries (AZHBs) are latent high-energy systems for grid-level energy storage, yet usually suffer from poor high-rate endurability caused by the formation of “dead species”. Herein, via an electrochemically-densified cathode-interface-reaction layer (CIRL), Zn||I−Br batteries involving interhalogen reactions between the I 2 cathode and Br − from the electrolytes are initially achieved with excellent high-rate endurability. Different from that in diluted electrolytes, the CIRL formed in Br − -concentrated electrolyte is denser and water-lean, which enables halogen species conversion with a more rapid charge transfer and lower activation energy. More importantly, the CIRL robustly affords a decent I 2 conservation by accelerated conversion kinetics and limited species diffusion, thereby endowing the Zn||I−Br batteries with an ultralong high-rate lifespan. The electrochemical mechanism is sufficiently verified by multiple spectral characterizations. Consequently, Zn||I−Br batteries in Br − -concentrated (20 m) electrolytes exhibit an overwhelming rate capability and lifespan to those in Br − -diluted (2 m) electrolytes. Typically, when cycled at a large current density of 10 A g −1 , an ultralong lifespan of over 25,000 cycles is achieved with a high retention of 98.3 %. This study provides new insight into the CIRL-dictated active species conservation for high-rate endurable AZHBs, which could apply to other high-energy interhalogen batteries.}, archive = {J_ANGEW}, author = {Zhenfeng Feng and Yongchao Tang and Yue Wei and Jiangfeng He and Guigui Liu and Jianping Yan and Jintu Qi and Zhiheng Shi and Qi Yang and Zhipeng Wen and Minghui Ye and Yufei Zhang and Xiaoqing Liu and Cheng Chao Li}, doi = {10.1002/anie.202416755}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416755}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reducing dead species by electrochemically-densified cathode-interface-reaction layer towards high-rate-endurable Zn||I-br batteries}, volume = {64}, year = {2025}, }
• (2025). Terminal fluorination modulates crystallinity and aggregation of fully non-fused ring electron acceptors for high-performance and durable near-infrared organic photodetectors. ANGEW, 64(4), e202416751. (www)

  @article{ , abstract = {High dark current density ( J d ) severely hinders further advancement of near-infrared organic photodetectors (NIR OPDs). Herein, we tackle this grand challenge by regulating molecular crystallinity and aggregation of fully non-fused ring electron acceptors (FNREAs). TBT-V-F, which features fluorinated terminals, notably demonstrates crystalline intensification and a higher prevalence predominance of J-aggregation compared to its chlorinated counterpart (TBT-V-Cl). The amalgamation of advantages confers TBT-V-F-based OPDs with lower nonradiative energy loss, improved charge transport, decreased energetic disorder, and reduced trap density. Consequently, the corresponding self-powered OPDs exhibit a 40-fold decrease in J d , a remarkable increase in detectivity ( D * sh ), faster response time, and superior thermal stability compared to TBT-V-Cl-based OPDs. Further interfacial optimization results in an ultra-low J d of 7.30×10 -12 A cm −2 with D * sh over 10 13 Jones in 320–920 nm wavelength and a climax of 2.2×10 14 Jones at 800 nm for the TBT-V-F-based OPDs, representing one of the best results reported to date. This work paves a compelling material-based strategy to suppress J d for highly sensitive NIR OPDs, while also illustrates the viability of FNREAs in construction of stable and affordable NIR OPDs for real-world applications.}, archive = {J_ANGEW}, author = {Wenxu Liu and Wenjing Guo and Lulu Fu and Yuxin Duan and Guoxin Han and Jiaxin Gao and Huayi Liu and Yuxing Wang and Zaifei Ma and Yao Liu}, doi = {10.1002/anie.202416751}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416751}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Terminal fluorination modulates crystallinity and aggregation of fully non-fused ring electron acceptors for high-performance and durable near-infrared organic photodetectors}, volume = {64}, year = {2025}, }
• (2025). Surface matrix-mediated cation exchange of perovskite quantum dots for efficient solar cells. ANGEW, 64(4), e202416747. (www)

  @article{ , abstract = {Cesium-formamidinium lead triiodide perovskite quantum dot (Cs x FA 1-x PbI 3 PQD) is very promising for photovoltaic applications due to its good phase stability and outstanding optoelectronic properties. However, achieving the Cs x FA 1-x PbI 3 PQDs with tunable compositions and robust surface matrix remains a challenge. Here, the surface matrix-mediated cation exchange of PQDs is proposed, in which a bi-functional molecule, tetrafluoroborate methylammonium (FABF 4 ), is applied for the cation exchange and stabilizing surface matrix of PQDs. The results reveal that the FA + of FABF 4 molecules could exchange the Cs + of CsPbI 3 PQDs forming alloy Cs x FA 1-x PbI 3 PQDs, allowing to tune the spectroscopies of PQDs. Meanwhile, the BF 4 − of FABF 4 molecules can effectively stabilize the surface lattice and substantially diminish the surface vacancies of PQDs, improving the phase stability and optoelectronic properties of PQDs. Consequently, Cs x FA 1-x PbI 3 PQD solar cells deliver an efficiency of up to 17.49 %, which is the highest value of Cs x FA 1-x PbI 3 PQD solar cells. This work provided important design principles for the composition and surface matrix regulation of PQDs for high-performance solar cells or other optoelectronic devices.}, archive = {J_ANGEW}, author = {Guoliang Wang and Yuqi Sun and Xinyi Mei and Mingxu Zhang and Junming Qiu and Zhimei Sun and Xiaoliang Zhang}, doi = {10.1002/anie.202416747}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416747}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface matrix-mediated cation exchange of perovskite quantum dots for efficient solar cells}, volume = {64}, year = {2025}, }
• (2025). Engineering active sites of Metal/Metal oxide catalysts by oxide ligand overlayers. ANGEW, 64(4), e202416746. (www)

  @article{ , abstract = {Engineering sites of supported metal catalysts is essential to enhancing activity and selectivity. Such enhancement is typically achieved by particle size modification, surface alloying, or attaching molecular ligands. Yet, control strategies for complex, multifunctional molecules and catalysts, where selectivity is crucial, are lacking. Here, we demonstrate that submonolayer WO x with tunable coverage preferentially decorates well-coordinated Pt terrace sites as a stable ligand. By combining experimental kinetics with probe molecules, in situ spectroscopies, and first-principles modeling, we show that the WO x coverage on Pt modifies the metal-to-acid site balance while retaining the acid strength intact and results in optimal reactivity for metal-acid catalyzed reactions at a specific metal, size, and support-dependent WO x coverage. The oxide can also alter the reactant adsorption mode, reversing selectivity and pathways from terrace- to step-dominated, as evidenced in furfural decarbonylation and hydrogenation. The insights open avenues for improving metal/metal oxide catalysts beyond the specific system.}, archive = {J_ANGEW}, author = {Jiahua Zhou and Piaoping Yang and Stavros Caratzoulas and Weiqing Zheng and Dionisios G. Vlachos}, doi = {10.1002/anie.202416746}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering active sites of Metal/Metal oxide catalysts by oxide ligand overlayers}, volume = {64}, year = {2025}, }
• (2025). Harnessing free sulfate groups in glycosylation reactions. ANGEW, 64(4), e202416743. (www)

  @article{ , abstract = {General strategies for synthesizing sulfated oligosaccharides employ the protection of sulfate groups for glycosylation or post-sulfation after the synthesis of oligosaccharides. However, the chemical behavior of free sulfate groups in glycosylation reactions has not been thoroughly studied. We examined several glycosyl donors with free sulfate groups, but neither glycosyl imidates nor thioglycosides achieved products. Conversely, activating 6-sulfated GalNAc donors with either a 2-NTroc group or 2-O-acetyl group using an ortho-hexynylbenzoate group at the anomeric position yielded β-glycosides in good yield. These results indicate that glycosylations with a free sulfate group can be performed and that the neighboring group participation of 2-NHTroc and 2-O-acetyl groups works even with an unprotected sulfate group at the 6-position. Ab initio calculations supported the formation of acyloxonium-cation via 2-O-acyl participation. Additionally, glycosylation reactions under various counter cations of the sulfate group, such as Na + , Li + , K + , Ba 2+ , and pyridinium were examined. Results showed that sodium and lithium salt donors yielded the products in good yield. These results were also supported by ab initio calculations. Practical glycosylation reactions between disaccharide donor-acceptor pairs with free sulfate groups successfully yielded the sulfated tetrasaccharides. This study also discusses how a sodium salt acts as a protecting group during glycosylation.}, archive = {J_ANGEW}, author = {Yuta Maki and Akihiro Manbo and Junpei Abe and Hiroki Nobutou and Kohtaro Hirao and Ryo Okamoto and Masayuki Izumi and Shusuke Yamanaka and Mitsutaka Okumura and Yasuhiro Kajihara}, doi = {10.1002/anie.202416743}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416743}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing free sulfate groups in glycosylation reactions}, volume = {64}, year = {2025}, }
• (2025). A detailed view on the (Re)isomerization dynamics in microbial rhodopsins using complementary near-UV and IR readouts. ANGEW, 64(4), e202416742. (www)

  @article{ , abstract = {Isomerization is a key process in many (bio)chemical systems. In microbial rhodopsins, the photoinduced isomerization of the all- trans retinal to the 13- cis isomer initiates a cascade of structural changes of the protein. The interplay between these changes and the thermal relaxation of the isomerized retinal is one of the crucial determinants for rhodopsin functionality. It is therefore important to probe this dynamic interplay with chromophore specific markers that combine gapless temporal observation with spectral sensitivity. Here we utilize the near-UV and mid-IR fingerprint region in the framework of a systematic (time-resolved) spectroscopic study on H + - ( Hs BR, (G)PR), Na + - (KR2, Er NaR) and Cl − -( Nm HR) pumps. We demonstrate that the near-UV region is an excellent probe for retinal configuration and—being sensitive to the electrostatic environment of retinal—even transient ion binding, which allows us to pinpoint protein specific mechanistic nuances and chromophore-charge interactions. The combination of the near-UV and mid-IR fingerprint region hence provides a spectroscopic analysis tool that allows a detailed, precise and temporally fully resolved description of retinal configurations during all stages of the photocycle.}, archive = {J_ANGEW}, author = {Marvin Asido and Gerrit H. U. Lamm and Jonas Lienert and Mariafrancesca La Greca and Jagdeep Kaur and Anne Mayer and Clemens Glaubitz and Joachim Heberle and Ramona Schlesinger and Kirill Kovalev and Josef Wachtveitl}, doi = {10.1002/anie.202416742}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416742}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A detailed view on the (Re)isomerization dynamics in microbial rhodopsins using complementary near-UV and IR readouts}, volume = {64}, year = {2025}, }
• (2025). Ring expansion toward fused diazabicyclo[3.1.1]heptanes through lewis acid catalyzed highly selective C−C/C−N bond cross-exchange reaction between bicyclobutanes and diaziridines. ANGEW, 64(4), e202416741. (www)

  @article{ , abstract = {The synthesis of bicyclic scaffolds has garnered considerable interest in drug discovery because of their ability to mimic benzene bioisosteres. Herein, we introduce a new approach that utilizes a Lewis acid (Sc(OTf) 3 )-catalyzed σ-bond cross-exchange reaction between the C−C bond of bicyclobutanes and the C−N bond of diaziridines to produce multifunctionalized and medicinally interesting azabicyclo[3.1.1]heptane derivatives. The reaction proceeds well with different bicyclobutanes and a broad range of aryl- as well as alkenyl-, but also alkyl-substituted diaziridines (up to 98 % yield). Conducting a scale-up experiment and exploring the synthetic transformations of the cycloadducts emphasized the practical application of the synthesis. Furthermore, a zinc-based chiral Lewis acid catalytic system was developed for the enantioselective version of this reaction (up to 96 % ee ).}, archive = {J_ANGEW}, author = {Heng-Xian He and Feng Wu and Xu Zhang and Jian-Jun Feng}, doi = {10.1002/anie.202416741}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416741}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ring expansion toward fused diazabicyclo[3.1.1]heptanes through lewis acid catalyzed highly selective C−C/C−N bond cross-exchange reaction between bicyclobutanes and diaziridines}, volume = {64}, year = {2025}, }
• (2025). Hubbard gap closure-induced dual-redox li-storage mechanism as the origin of anomalously high capacity and fast ion diffusivity in MOFs-like polyoxometalates. ANGEW, 64(4), e202416735. (www)

  @article{ , abstract = {MOFs-like polyoxometalate (POMs) electrodes, harvesting combined advantages of interlocking porosity and multi-electron transfer reaction, have already emerged as promising candidates for lithium-ion batteries (LIBs), yet the origins of the underlying redox mechanism in such materials remain a matter of uncertainty. Of critical challenges are the anomalously high storage capacities beyond their theoretical values and the fast ion diffusivity that cannot be satisfactorily comprehended in the theory of crystal lattice. Herein, for the first time we decode t 2g electron occupation-regulated dual-redox Li-storage mechanism as the true origin of extra capacity in POMs electrodes. The lattice and electronic transition of active centers and reaction intermediates were systematically decoupled through density functional theory (DFT) and a suite of structural spectroscopic investigations, such as X-ray absorption near-edge spectroscopy (XANES), soft X-ray absorption spectroscopy (sXAS) and 7 Li solid-state nuclear magnetic resonance (NMR). Enhanced V-t 2g orbital occupation by Li coordination significantly triggers the Hubbard gap closure and reversible Li deposition/dissolution at surface region. Conjugated V−O-Li configuration at interlayers endow Li + ion pathways along pore walls as the dominant contribution to the low migration barrier and fast diffusivity. As a result, remarkable cycle stability (~100 % capacity retention after 2000 cycles at 1 A g −1 ), extremely high specific capacity (1200 mAh g −1 at 100 mA g −1 ) and excellent rate performance (404 mAh g −1 at 8 A g −1 ) were achieved, providing new understandings on the underlying mechanism of POMs electrodes and pivotal guidance for dual-storage materials.}, archive = {J_ANGEW}, author = {Xinran Wang and Songjie Li and Feng Wu and Hailong Chen and W. Wenxing Chen and Wenbin Zhao and Kaidi Kang and Ruiqi Guo and Yuheng Sun and Liqing Zhai and Ran Zhao and Aolei Gao and Ying Bai and Chuan Wu}, doi = {10.1002/anie.202416735}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416735}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hubbard gap closure-induced dual-redox li-storage mechanism as the origin of anomalously high capacity and fast ion diffusivity in MOFs-like polyoxometalates}, volume = {64}, year = {2025}, }
• (2025). Regulating interface dipole interaction between ethers and active species toward highly stable li-SPAN batteries. ANGEW, 64(4), e202416731. (www)

  @article{ , abstract = {Sulfurized polyacrylonitrile (SPAN) is recognized as a promising organic cathode for long-lifespan lithium metal batteries. Nevertheless, the irreversible cleavage/formation of multiple sulfur-sulfur (S−S) bonds of SPAN within conventional ether-based electrolytes results in loss of active S species, severe capacity fading and shuttle effects. Herein, we propose a new electrolyte based on dipropyl ether (PE) solvent for Li-SPAN batteries. Benefiting from the particular chain-coordination structure and weak dipole interactions with Li + and active species, the resulting electrolyte not only achieves low desolvation energy barrier and high Li + transference number, but also displays stable electrolyte-electrode interface (EEI). Consequently, the full cells utilizing this electrolyte exhibit good cyclability, outstanding capacity retention and superior extreme-temperature (−50 °C to 50 °C) performance. Furthermore, the Ah-scale pouch cell with lean electrolyte (2.5 g Ah −1 ) achieves record cycle stability with 96.5 % capacity retention after 75 cycles, which deliver an initial specific energy density of 150 Wh kg −1 (based on the weight of the entire cell). Impressively, this strategy demonstrates universality in a series of organic electrodes employing with PE-based electrolytes. This work highlights the strategy for modulating the dipole interaction at EEI for long-lifespan Li-organic batteries at extreme conditions.}, archive = {J_ANGEW}, author = {Xinyi Liu and Shuang Wu and Zhimeng Hao and Long Shang and Mao Guo and Jinze Hou and Siyuan Shao and Haixia Li and Yixin Li and Yong Lu and Kai Zhang and Zhenhua Yan and Jun Chen}, doi = {10.1002/anie.202416731}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416731}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating interface dipole interaction between ethers and active species toward highly stable li-SPAN batteries}, volume = {64}, year = {2025}, }
• (2025). Nature-inspired n, o co-coordinated manganese single-atom catalyst for efficient hydrogen peroxide electrosynthesis. ANGEW, 64(4), e202416715. (www)

  @article{ , abstract = {The two-electron oxygen reduction reaction (2e − ORR) is a pivotal pathway for the distributed production of hydrogen peroxide (H 2 O 2 ). In nature, enzymes containing manganese (Mn) centers can convert reactive oxygen species into H 2 O 2 . However, Mn-based heterogeneous catalysts for 2e − ORR are scarcely reported. Herein, we developed a nature-inspired single-atom electrocatalyst comprising N, O co-coordinated Mn sites, utilizing carbon dots as the modulation platform (Mn CD/C). As-synthesized Mn CD/C exhibited exceptional 2e − ORR activity with an onset potential of 0.786 V and a maximum H 2 O 2 selectivity of 95.8 %. Impressively, Mn CD/C continuously produced 0.1 M H 2 O 2 solution at 200 mA/cm 2 for 50 h in the flow cell, with negligible loss in activity and H 2 O 2 faradaic efficiency, demonstrating practical application potential. The enhanced activity was attributed to the incorporation of Mn atomic sites into the carbon dots. Theoretical calculations revealed that the N, O co-coordinated structure, combined with abundant oxygen-containing functional groups on the carbon dots, optimized the binding strength of intermediate *OOH at the Mn sites to the apex of the catalytic activity volcano. This work illustrates that carbon dots can serve as a versatile platform for modulating the microenvironment of single-atom catalysts and for the rational design of nature-inspired catalysts.}, archive = {J_ANGEW}, author = {Yuan Zeng and Xin Tan and Zewen Zhuang and Chen Chen and Qing Peng}, doi = {10.1002/anie.202416715}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416715}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nature-inspired n, o co-coordinated manganese single-atom catalyst for efficient hydrogen peroxide electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). Polyoxometalate-based single-atom catalyst with precise structure and extremely exposed active site for efficient h2 evolution. ANGEW, 64(4), e202416711. (www)

  @article{ , abstract = {Single-atom catalysts with precise structure and extremely high catalytic efficiency remain a fervent focus in the fields of materials chemistry and catalytic science. Herein, a nickel-substituted polyoxometalate (POM) {NiSb 6 O 4 (H 2 O) 3 [β-Ni(hmta)SbW 8 O 31 ] 3 } 15− (NiPOM) with one extremely exposed nickel site [NiO 3 (H 2 O) 3 ] was synthesized using the conventional aqueous method. The uniform dispersion of single nickel center with well-defined structure was facilely achieved by anchoring nanosized NiPOM on graphene oxide (GO). The resulting NiPOM/GO can couple with CdS photoabsorber for the construction of low-cost and ultra-efficient hydrogen evolution system. The H 2 yield can reach to 2753.27 mmol g POM −1 h −1 , which represents a record value among all the POM-based photocatalytic systems. Remarkablely, an extremely high hydrogen yield of 3647.28 mmol g POM −1 h −1 was achieved with simultaneous photooxidation of commercial waste plastic, representing the first POM-based photocatalytic system for H 2 evolution and waste plastic conversion. This work highlights a straightforward strategy for constructing extremely exposed single-metal site with precise microenvironment by facilely manipulating nanosized molecular cluster to control individual atom.}, archive = {J_ANGEW}, author = {Zhuo-Ran Zhang and He-Yu Sui and Wen-Xiong Shi and Jing Ren and Shuang Yao and Tong-Bu Lu and Zhi-Ming Zhang}, doi = {10.1002/anie.202416711}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416711}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyoxometalate-based single-atom catalyst with precise structure and extremely exposed active site for efficient h2 evolution}, volume = {64}, year = {2025}, }
• (2025). Perylene-embedded helical nanographenes with emission up to 1010 nm: Synthesis, structures, and chiroptical properties. ANGEW, 64(4), e202416707. (www)

  @article{ , abstract = {Near-infrared (NIR) circularly polarized absorbing or emitting materials offer distinct advantages over their visible-light counterparts and have attracted considerable interest across various fields. Materials exhibiting NIR chiroptical properties with high fluorescence quantum yields ( Φ F ) are particularly rare. In this study, we report the synthesis of a series of helical nanographenes ( 1 , 2 , 3 , and 4 ), where perylene is fused with one to four hexa- peri -hexabenzocoronene (sub) units by a strategy involving Diels–Alder cycloaddition followed by a Scholl reaction. X-ray crystallographic analysis confirmed their structures, revealing helicene moieties integrated into a highly contorted framework. Benefiting from a similar distribution pattern of frontier molecular orbitals to perylene and extended π-conjugation, compounds 1 – 4 demonstrate respectable Φ F values of 31.9 %, 15.0 %, 13.7 %, and 6.5 %, respectively, with emission maxima reaching up to 1010 nm. Their enantiopure forms, isolated by preparative chiral HPLC, exhibit distinct circular dichroism signals and circularly polarized luminescence across a broad spectral range, extending from the ultraviolet to the NIR.}, archive = {J_ANGEW}, author = {Gui-Fei Huo and Wei-Tao Xu and Jinlian Hu and Yi Han and Wei Fan and Wei Wang and Zhe Sun and Hai-Bo Yang and Jishan Wu}, doi = {10.1002/anie.202416707}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416707}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Perylene-embedded helical nanographenes with emission up to 1010 nm: Synthesis, structures, and chiroptical properties}, volume = {64}, year = {2025}, }
• (2025). Cross-linkable fullerene electron transport layer with internal encapsulation capability for efficient and stable inverted perovskite solar cells. ANGEW, 64(4), e202416703. (www)

  @article{ , abstract = {A stable and compact fullerene electron transport layer (ETL) is crucial for high-performance inverted perovskite solar cells (PSCs). However, traditional fullerene-based ETLs like C 60 and PCBM are prone to aggregate under operational conditions, a challenge recently recognized by academic and industrial researchers. Here, we designed and synthesized a novel cross-linkable fullerene molecule, bis((3-methyloxetan-3-yl)methyl) malonate-C 60 monoadduct (BCM), for use as an ETL in PSCs. Upon a low-temperature annealing at 100 °C, BCM undergoes in situ cross-linking to form a robust cross-linked BCM (CBCM) film, which demonstrates excellent electron mobility and a suitable band structure for efficient PSCs. Our results show that PSCs incorporating CBCM-based ETL achieve an impressive efficiency of 25.89 % (certified: 25.36 %), significantly surpassing the 23.25 % efficiency of PCBM-based devices. The intramolecular covalent interactions within CBCM films effectively prevent aggregation and enhance film compactness, creating an internal encapsulation layer that mitigates the decomposition and ion migration of perovskite components. Consequently, CBCM-based PSCs show exceptional stability, maintaining 97.8 % of their initial efficiency after 1000 hours of maximum power point tracking, compared to only 78.6 % retention in PCBM-based devices after less than 820 hours.}, archive = {J_ANGEW}, author = {Enlong Hou and Shuo Cheng and Yujue Qiu and Xingyu Chen and Jingfu Chen and Chao Sun and Hui Zhang and Jinxin Yang and Xinjing Zhao and Liqiang Xie and Zuochang Chen and Chengbo Tian and Zhanhua Wei}, doi = {10.1002/anie.202416703}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416703}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cross-linkable fullerene electron transport layer with internal encapsulation capability for efficient and stable inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Catalytically active site mapping realized through energy transfer modeling. ANGEW, 64(4), e202416695. (www)

  @article{ , abstract = {The demands of a sustainable chemical industry are a driving force for the development of heterogeneous catalytic platforms exhibiting facile catalyst recovery, recycling, and resilience to diverse reaction conditions. Homogeneous-to-heterogeneous catalyst transitions can be realized through the integration of efficient homogeneous catalysts within porous matrices. Herein, we offer a versatile approach to understanding how guest distribution and evolution impact the catalytic performance of heterogeneous host–guest catalytic platforms by implementing the resonance energy transfer (RET) concept using fluorescent model systems mimicking the steric constraints of targeted catalysts. Using the RET-based methodology, we mapped condition-dependent guest (re)distribution within a porous support on the example of modular matrices such as metal–organic frameworks (MOFs). Furthermore, we correlate RET results performed on the model systems with the catalytic performance of two MOF-encapsulated catalysts used to promote CO 2 hydrogenation and ring-closing metathesis. Guests are incorporated using aperture-opening encapsulation, and catalyst redistribution is not observed under practical reaction conditions, showcasing a pathway to advance catalyst recyclability in the case of host–guest platforms. These studies represent the first generalizable approach for mapping the guest distribution in heterogeneous host–guest catalytic systems, providing a foundation for predicting and tailoring the performance of catalysts integrated into various porous supports.}, archive = {J_ANGEW}, author = {William J. Thompson and Buddhima K. P. Maldeni Kankanamalage and Grace C. Thaggard and Kyoung Chul Park and Corey R. Martin and Jia Niu and Jeffery A. Byers and Natalia B. Shustova}, doi = {10.1002/anie.202416695}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416695}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytically active site mapping realized through energy transfer modeling}, volume = {64}, year = {2025}, }
• (2025). Mn−Ce symbiosis: Nanozymes with multiple active sites facilitate scavenging of reactive oxygen species (ROS) based on electron transfer and confinement anchoring. ANGEW, 64(4), e202416686. (www)

  @article{ , abstract = {Regulating appropriate valence states of metal active centers, such as Ce 3+ /Ce 4+ and Mn 3+ /Mn 2+ , as well as surface vacancy defects, is crucial for enhancing the catalytic activity of cerium-based and manganese-based nanozymes. Drawing inspiration from the efficient substance exchange in rhizobia-colonized root cells of legumes, we developed a symbiosis nanozyme system with rhizobia-like CeO x nanoclusters robustly anchored onto root-like Mn 3 O 4 nanosupports (CeO x /Mn 3 O 4 ). The process of “substance exchange” between Ce and Mn atoms—reminiscent of electron transfer—not only fine-tunes the metal active sites to achieve optimal Ce 3+ /Ce 4+ and Mn 3+ /Mn 2+ ratios but also enhances the vacancy ratio through interface defect engineering. Additionally, the confinement anchoring of CeO x on Mn 3 O 4 ensures efficient electron transfer in catalytic reactions. The final CeO x /Mn 3 O 4 nanozyme demonstrates potent catalase-like (CAT-like) and superoxide dismutase-like (SOD-like) activities, excelling in both chemical settings and cellular environments with high reactive oxygen species (ROS) levels. This research not only unveils a novel material adept at effectively eliminating ROS but also presents an innovative approach for amplifying the efficacy of nanozymes.}, archive = {J_ANGEW}, author = {Juan Zhang and Zhihua Wang and Xingen Lin and Xiaoping Gao and Qiuping Wang and Rui Huang and Yaner Ruan and Haonan Xu and Lin Tian and Chen Ling and Ran Shi and Suowen Xu and Kong Chen and Yuen Wu}, doi = {10.1002/anie.202416686}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416686}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mn−Ce symbiosis: Nanozymes with multiple active sites facilitate scavenging of reactive oxygen species (ROS) based on electron transfer and confinement anchoring}, volume = {64}, year = {2025}, }
• (2025). Dual active sites with charge-asymmetry in organic semiconductors promoting C−C coupling for highly efficient CO2 photoreduction to ethanol. ANGEW, 64(4), e202416684. (www)

  @article{ , abstract = {Selective CO 2 photoreduction into high-energy-density and high-value-added C 2 products is an ideal strategy to achieve carbon neutrality and energy shortage, but it is still highly challenging due to the large energy barrier of the C−C coupling step and severe exciton annihilation in photocatalysts. Herein, strong and localized charge polarization is successfully induced on the surface of melon-based organic semiconductors by creating dual active sites with a large charge asymmetry. Confirmed by multiscale characterization and theoretical simulations, such asymmetric charge distribution, originated from the oxygen dopants and nitrogen vacancies over melon-based organic semiconductors, reduces exciton binding energy and boosts exciton dissociation. The as-formed charge polarization sites not only donate electrons to CO 2 molecules but also accelerate the coupling of asymmetric *CO*CO intermediates for CO 2 photoreduction into ethanol by lowering the energy barrier of this process. Consequently, an exceptionally high selectivity of up to 97 % for C 2 H 5 OH and C 2 H 5 OH yield of 0.80 mmol g −1 h −1 have been achieved on this dual active sites organic semiconductor. This work, with its potential applicability to a variety of non-metal multi-site catalysts, represents a versatile strategy for the development of advanced catalysts tailored for CO 2 photoreduction reactions.}, archive = {J_ANGEW}, author = {Haotian Tan and Wenping Si and Rongao Zhang and Wei Peng and Xiaoqing Liu and Xusheng Zheng and Feng Hou and Lichang Yin and Ji Liang}, doi = {10.1002/anie.202416684}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual active sites with charge-asymmetry in organic semiconductors promoting C−C coupling for highly efficient CO2 photoreduction to ethanol}, volume = {64}, year = {2025}, }
• (2025). Ligand-responsive artificial Protein–Protein communication for field-deployable cell-free biosensing. ANGEW, 64(4), e202416671. (www)

  @article{ , abstract = {Natural protein–protein communications, such as those between transcription factors (TFs) and RNA polymerases/ribosomes, underpin cell-free biosensing systems operating on the transcription/translation (TXTL) paradigm. However, their deployment in field analysis is hampered by the delayed response (hour-level) and the complex composition of in vitro TXTL systems. For this purpose, we present a de novo-designed ligand-responsive artificial protein–protein communication (LIRAC) by redefining the connection between TFs and non-interacting CRISPR/Cas enzymes. By rationally designing a chimeric DNA adaptor and precisely regulating its binding affinities to both proteins, LIRAC immediately transduces target-induced TF allostery into rapid CRISPR/Cas enzyme activation within a homogeneous system. Consequently, LIRAC obviates the need for RNA/protein biosynthesis inherent to conventional TXTL-based cell-free systems, substantially reducing reaction complexity and time (from hours to 10 minutes) with improved sensitivity and tunable dynamic range. Moreover, LIRAC exhibits excellent versatility and programmability for rapidly and sensitively detecting diverse contaminants, including antibiotics, heavy metal ions, and preservatives. It also enables the creation of a multi-protein communication-based tristate logic for the intelligent detection of multiple contaminants. Integrated with portable devices, LIRAC has been proven effective in the field analysis of environmental samples and personal care products, showcasing its potential for environmental and health monitoring.}, archive = {J_ANGEW}, author = {Ke Wang and Siqian Liu and Shuqi Zhou and Aori Qileng and Dingyi Wang and Yingju Liu and Chunlai Chen and Chunyang Lei and Zhou Nie}, doi = {10.1002/anie.202416671}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416671}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-responsive artificial Protein–Protein communication for field-deployable cell-free biosensing}, volume = {64}, year = {2025}, }
• (2025). A tricyclic framework with integrated B←N and cyano dual functionalization for superior n-type organic electronics. ANGEW, 64(4), e202416669. (www)

  @article{ , abstract = {n-Type conjugated polymers featuring low-lying lowest unoccupied molecular orbital (LUMO) energy levels are essential for achieving high-performance n-type organic thin-film transistors (OTFTs) and organic thermoelectrics (OTEs). However, the synthesis of acceptors with strong electron-withdrawing characteristics presents a significant challenge. Herein, a peripheral functionalization strategy is employed on the tricyclic framework anthracene by introducing dual N,O -bidentate BF 2 /B(CN) 2 groups to enhance its electron-withdrawing capability. This approach successfully navigates synthetic challenges, leading to the development of two novel acceptor building blocks: DBNF and DBNCN. Compared to the counterparts with a single N,O -bidentate BF 2 /B(CN) 2 moiety, DBNF and DBNCN exhibit an extended π-backbone, enhanced molecular packing, and improved electron-withdrawing properties. Utilizing these innovative acceptor monomers, copolymers, PDBNF and PDBNCN, are synthesized, which exhibit considerably suppressed LUMO ≈−4.0 eV. The deep LUMO of PDBNF together with its favourable bimodal packing orientation leads to remarkable electron mobility of 3.04 cm 2 V −1 s −1 with improved stability in OTFTs. Importantly, efficient n-doping in OTEs is achieved with PDBNCN, exhibiting exceptional conductivity of 95.5 S cm −1 and a maximum power factor of 147.8 μW m −1 K −2 —among the highest reported for solution-processed n-type polymers. This work underscores the effectiveness of introducing dual B←N and cyano functionalities in attaining high-performance n-type plastic electronics.}, archive = {J_ANGEW}, author = {Zhen Jiang and Di Liu and Yang Wang and Wei Song and Dongsheng Yan and Ziyi Ge and Yunqi Liu}, doi = {10.1002/anie.202416669}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A tricyclic framework with integrated B←N and cyano dual functionalization for superior n-type organic electronics}, volume = {64}, year = {2025}, }
• (2025). Self-organized integrated electrocatalyst on oxygen conversion for highly durable zinc-air batteries. ANGEW, 64(4), e202416664. (www)

  @article{ , abstract = {Efficient bifunctional electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are key for clean energy applications such as rechargeable metal-air batteries. Highly efficient bifunctional electrocatalysts have been the focus of great attention by scientists. Here, an innovative and continuous growth method is established to fabricate integrated Janus structure Co 3 O 4 /CoNGDY catalyst, which can work for bifunctional oxygen catalytic conversion, achieving highly durable zinc-air batteries. Embedded in the hydrangea-shaped N-doped graphdiyne (NGDY), the Co 3 O 4 /CoNGDY is self-organized by CoNGDY at the NGDY contact sites and Co 3 O 4 at the upper part, in which Co 3 O 4 works as OER catalyst and CoNGDY acts as ORR catalyst. Due to the incomplete charge transfer within integrated structure, NGDY reduces the d-band center of the Co sites, so the adsorption strength of intermediates is balanced, and the catalytic activity for ORR/OER is increased. The Co 3 O 4 /CoNGDY can serve as an efficient air electrode of rechargeable zinc-air batteries. The rechargeable Co 3 O 4 /CoNGDY-based aqueous zinc-air batteries demonstrate excellent performance with a high specific capacity of 746.8 mAh g −1 and an extremely long lifetime of more than 5000 hours. The recoverable modularized cylindrical Co 3 O 4 /CoNGDY-based solid-state zinc-air batteries with a power density of up to 167.6 mW cm −2 can be achieved.}, archive = {J_ANGEW}, author = {Qian Chang and Feng He and Zhihui Zhang and Xinlong Fu and Yi Wang and Changshui Huang and Yuliang Li}, doi = {10.1002/anie.202416664}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-organized integrated electrocatalyst on oxygen conversion for highly durable zinc-air batteries}, volume = {64}, year = {2025}, }
• (2025). Friedel–Crafts reactivity with sulfondiimidoyl fluorides for the synthesis of heteroaryl sulfondiimines. ANGEW, 64(4), e202416638. (www)

  @article{ , abstract = {Sulfur functional groups are ubiquitous in molecules used in the pharmaceutical and agrochemical industries, and within these collections sulfones hold a prominent position. The double aza-analogues of sulfones, sulfondiimines, offer significant potential in discovery chemistry but to date their applications have been limited by the lack of convenient synthetic routes. The existing methods mainly rely on imination of low-valent-sulfur intermediates, or the combination of pre-formed organometallic reagents and electrophilic S(VI)-functionalities. Herein, we describe a Friedel–Crafts-type reaction of sulfondiimidoyl fluorides with (hetero)aryls. This new SuFEx reactivity benefits from broad functional group tolerance, mild reaction conditions, and does not require the use of pre-formed organometallic reagents. The efficient use of unprotected indoles and pyrroles, as well as furan, thiophene and carbocyclic aromatics, further demonstrates the advantages of these reactions. We show that the reactivity of the sulfondiimidoyl fluorides can be tuned by switching the N -substituents, allowing an expansion of the range of coupling partners. The utility of the transformation is exemplified by the synthesis of the sulfondiimine analogue of the HIV-I reverse transcriptase-inhibitor L-737,126.}, archive = {J_ANGEW}, author = {Ming-Kai Wei and Ze-Xin Zhang and Mingyan Ding and Michael C. Willis}, doi = {10.1002/anie.202416638}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416638}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Friedel–Crafts reactivity with sulfondiimidoyl fluorides for the synthesis of heteroaryl sulfondiimines}, volume = {64}, year = {2025}, }
• (2025). Multi-electron transfer halide cathode materials based on intercalation-conversion reaction towards all-solid-state lithium batteries. ANGEW, 64(4), e202416635. (www)

  @article{ , abstract = {All-solid-state lithium batteries (ASSLBs) with non-flammable solid-state electrolytes offer high energy density and enhanced safety. However, their energy densities are greatly limited by low-capacity and low-ionic-conductivity oxide cathode materials, typically relying on the intercalation-deintercalation mechanism with a catholyte content of 15–30 wt %. Here we introduce the Li x FeX x+2 (X=Cl, Br) families as high-capacity and high-ionic-conductivity alternatives, operating via a 3 mol e − transfer intercalation-conversion coupling reaction. Notably, the catholyte-free ASSLBs using 95 wt % LiFeCl 3 active material delivers a remarkable capacity of 446 mAh g −1 and a high energy density of 912 Wh kg −1 , which surpasses most oxide cathode materials. Of particular interest is the formation of amorphous Fe during the conversion process. The amorphous Fe exhibits high activity, catalyzing the conversion of LiX back to Li x FeX x+2 , which proves instrumental in realizing reversible intercalation-conversion reactions. These halide cathode materials represent a significant advancement towards high-energy-density ASSLBs.}, archive = {J_ANGEW}, author = {Xu Zhou and Ming Jiang and Yuhao Duan and Zhenghao Jia and Cheng Yuan and Kai Feng and Qiang Fu and Liang Zhang and Xiaofei Yang and Xianfeng Li}, doi = {10.1002/anie.202416635}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416635}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-electron transfer halide cathode materials based on intercalation-conversion reaction towards all-solid-state lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed γ-C(sp3)−H lactamization and iminolactonization. ANGEW, 64(4), e202416634. (www)

  @article{ , abstract = {Despite extensive efforts to develop γ-lactamization reactions for pyrrolidinone synthesis using either cyclometallation, C−H insertion, or radical C−H abstraction strategies, γ-lactamization reactions of aliphatic amides using practical catalysts and common protecting groups remain extremely rare. Herein we report copper-catalyzed γ-C(sp 3 )−H lactamization and iminolactonization of tosyl-protected aliphatic amides using inexpensive Selectfluor as the sole oxidant. A switchable selectivity of γ-lactams or γ-iminolactones can be obtained by using two different sets of reaction conditions. Notably, structurally diverse spiro-, fused-, and bridged-lactams and iminolactones, as well as isoindolinones are accessible by this method. Further derivatization of the γ-lactam products enables the synthesis of a range of biologically important motifs, including γ-amino acids, δ-amino alcohols, and pyrrolidines.}, archive = {J_ANGEW}, author = {Tao Sheng and Zhe Zhuang and Zhihan Zhao and Md Emdadul Hoque and Jin-Quan Yu}, doi = {10.1002/anie.202416634}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416634}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed γ-C(sp3)−H lactamization and iminolactonization}, volume = {64}, year = {2025}, }
• (2025). High-entropy electrolyte driven by multi-solvation structures for long-lifespan aqueous zinc metal pouch cells. ANGEW, 64(4), e202416619. (www)

  @article{ , abstract = {Aqueous zinc metal batteries (AZMBs) are promising candidates for grid-scale energy storage due to their low cost and high safety. However, the poor stability and the unfavorable freezing point of aqueous electrolytes hinder their actual application. Herein, a ternary salts-based high-entropy electrolyte (HEE) composed of Zn 0.2 Na 0.4 Li 0.4 (ClO 4 ) 1.2 ⋅ 7H 2 O is proposed to address the above issues. The addition of perchlorate salts with different cations reduces the size of ion clusters, significantly increases the solvation structure species, and promotes the anion-rich Zn 2+ solvation structures, resulting in an enlarged electrochemical stability window, favorable viscosity and ionic conductivity, and low freezing point. Furthermore, advanced characterization and theoretical calculations confirm that multiple types of solvation structures effectively increase the entropy of the electrolyte. As a consequence, the Zn/Zn symmetric cells in HEE can sustainably cycle for at least 1000 hours and 1500 hours under room and subzero temperatures, respectively. The Na 0.33 V 2 O 5 /Zn and polyaniline/Zn full cells can even last for 30000 and 20000 cycles without capacity decay at −20 °C, respectively. The pouch cells employing HEE deliver promising capacity and stability, even at high mass loading of active materials. This strategy of introducing multiple salts with different cations to construct a high-entropy environment provides a facile approach for high-performance and long-lifespan AZMBs across a wide temperature range.}, archive = {J_ANGEW}, author = {Ziqing Wang and Jiefeng Diao and Rinish R. Vaidyula and Graeme Henkelman and C. Buddie Mullins}, doi = {10.1002/anie.202416619}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416619}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy electrolyte driven by multi-solvation structures for long-lifespan aqueous zinc metal pouch cells}, volume = {64}, year = {2025}, }
• (2025). Localized high-concentration electrolyte for all-carbon rechargeable dual-ion batteries with durable interfacial chemistry. ANGEW, 64(4), e202416610. (www)

  @article{ , abstract = {Lithium-based rechargeable dual-ion batteries (DIBs) based on graphite anode-cathode combinations have received much attention due to their high resource abundance and low cost. Currently, the practical realization of the batteries is hindered by easy oxidation of the electrolyte at the cathode interface, and solvent co-intercalation at the anode-electrolyte interface. Configuration of a “solvent-in-salt” electrolyte with a high concentration of Li salt is expected to stabilize the electrolyte chemistry versus both electrodes, yet inevitably reduces the mobility of the solvated working ions and increases the cost of the electrolyte. Herein, we propose to build a localized high-concentration electrolyte by adding hydrofluoroether as the diluent to reduce the salt content while improving the solvation structure, allowing more anions to enter the inner solvation sheath. The new electrolyte helps to form uniform and thin interfaces, with elevated contents of inorganic fluorides, on both electrodes, which effectively suppress electrolyte oxidation at the cathode and optimize electrolyte-electrode compatibility at the anode while facilitating charge transfer across the interface. Consequently, the DIBs with graphite as anode and cathode operate for 3000 cycles and retain a high-capacity retention of 95.7 %, highlighting the importance of stable interfacial chemistry in boosting the electrochemical performance of DIBs.}, archive = {J_ANGEW}, author = {Rui Liu and Yan-Song Xu and Rui Zhou and Shuang-Jie Tan and Yun-Nuo Li and Si-Jie Jiang and Sen Xin and Yu-Guo Guo and Fei-Fei Cao}, doi = {10.1002/anie.202416610}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416610}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Localized high-concentration electrolyte for all-carbon rechargeable dual-ion batteries with durable interfacial chemistry}, volume = {64}, year = {2025}, }
• (2025). GlutaR: A high-performance fluorescent protein-based sensor for spatiotemporal monitoring of glutamine dynamics in vivo. ANGEW, 64(4), e202416608. (www)

  @article{ , abstract = {Glutamine is the most abundant amino acid in human blood and muscle, and is integral to a wide variety of functions in cancer cells. However, the inability to monitor the subcellular distribution of glutamine in real-time has obscured understanding of glutamine metabolism under physiological and pathological conditions. Here, we report the development of a genetically encoded fluorescent sensor and demonstrate how this GlnBP-cpYFP fusion “GlutaR sensor” undergoes glutamine-induced conformational changes reflected in detectable fluorescence responses. Obtained after iterative screening of approximately 1,600 variants, GlutaR exhibits a ratiometric readout, fast response kinetics, and high responsivity (R 488/405 of ~1000 %), and we demonstrate its selectivity for monitoring glutamine fluctuations in multiple cell types. Additionally, using digitonin permeabilization of GlutaR HeLa cells, we generated a calibration curve and performed in situ titration to quantify free glutamine concentrations in subcellular compartments (cytosol, nucleus, mitochondria). Subsequently, we applied GlutaR to investigate how chemical and genetic inhibition of glutamine synthetase (GS) and glutaminase (GLS) differentially alter glutamine levels in subcellular compartments. Finally, we demonstrate GlutaR's ability to monitor dynamic glutamine levels in muscle and liver tissues of diabetic mice in vivo . These findings collectively demonstrate GlutaR as a versatile tool for the spatiotemporal characterization of glutamine metabolism in living cells and tissues.}, archive = {J_ANGEW}, author = {Bingjie Liu and Zijie Zhao and Pengcheng Wang and Kamiran Aihemaiti and Lixin Zhu and Qingpeng Wei and Wenzhe Li and Xia Yuan and Jing Wu and Changtao Jiang and Min Hao and Jing Wang}, doi = {10.1002/anie.202416608}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {GlutaR: A high-performance fluorescent protein-based sensor for spatiotemporal monitoring of glutamine dynamics in vivo}, volume = {64}, year = {2025}, }
• (2025). Simultaneous suppression of multilayer ion migration via molecular complexation strategy toward high-performance regular perovskite solar cells. ANGEW, 64(4), e202416605. (www)

  @article{ , abstract = {The migration and diffusion of Li + , I − and Ag impedes the realization of long-term operationally stable perovskite solar cells (PSCs). Herein, we report a multifunctional and universal molecular complexation strategy to simultaneously stabilize hole transport layer (HTL), perovskite layer and Ag electrode by the suppression of Li + , I − and Ag migration via directly incorporating bis(2,4,6-trichlorophenyl) oxalate (TCPO) into HTL. Meanwhile, TCPO co-doping results in enhanced hole mobility of HTL, advantageous energy band alignment and mitigated interfacial defects, thereby leading to facilitated hole extraction and minimized nonradiative recombination losses. TCPO-doped regular device achieves a peak power conversion efficiency (PCE) of 25.68 % (certified 25.59 %). The unencapsulated TCPO doped devices maintain over 90 % of their initial efficiencies after 730 h of continuous operation under one sun illumination, 2800 h of storage at 30 % relative humidity, and 1200 h of exposure to 65 °C, which represents one of the best stabilities reported for regular PSCs. This work provides a new approach to enhance the PCE and long-term stability of PSCs by host–guest complexation strategy via rational design of multifunctional ligand molecules.}, archive = {J_ANGEW}, author = {Qian Zhou and Yingying Yang and Dongmei He and Ke Yang and Yue Yu and Xinxing Liu and Jiajia Zhang and Xuxia Shai and Jinsong Wang and Jianhong Yi and Meicheng Li and Jiangzhao Chen}, doi = {10.1002/anie.202416605}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416605}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous suppression of multilayer ion migration via molecular complexation strategy toward high-performance regular perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Deep-red emitting Copper(I) indenediyltrisphosphine complexes with minimized skeletal vibrations and configurational disorder. ANGEW, 64(4), e202416583. (www)

  @article{ , abstract = {The full width at half maximum (FWHM) of emission spectra, which plays an important role in determining color purity, may not always receive sufficient attention in the design of emissive materials. Particularly for the red emitter, the traditional focus has been on emission maxima, yet broad FWHM values can significantly change the perceived color. For example, the red color (λ em =616–677 nm) emitted from reported Cu(I) complexes is perceived as orange to yellow if FWHM is large. To reduce FWHM, we incorporated a strained and rigid metalaphosphadicyclopenta[ a,f ]pentalene motif into Cu(I) complexes using trisphosphine ligands featuring a 1 H -indene-2,3-diyl backbone ( ITP ). Herein, we present the synthesis, structure, and emission properties of ITP-MX and the congeners, showcasing genuinely deep-red emission with narrow FWHM values of 56 nm. These materials exhibit color coordinates close to pure red on the CIE diagram, unlike reported broader-emitting counterparts. Measurement of the entropy of disorder of the emissive crystal by a recently reported statistical mechanical method revealed a quantitative correlation between FWHM and the increase in the number of microstates (the degree of freedom) of the crystals and suggested that mechanical stress can increase the entropy of the crystal, which results in emission broadening.}, archive = {J_ANGEW}, author = {Shota Fukuma and Jiarui Fu and Takayuki Nakamuro and Rui Shang and Eiichi Nakamura}, doi = {10.1002/anie.202416583}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416583}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Deep-red emitting Copper(I) indenediyltrisphosphine complexes with minimized skeletal vibrations and configurational disorder}, volume = {64}, year = {2025}, }
• (2025). Regulating electric double layer via self-assembled monolayer for stable Solid/Electrolyte interphase on mg metal anode. ANGEW, 64(4), e202416582. (www)

  @article{ , abstract = {Modulating the cationic solvation structure with high donor-number (DN) additive is an effective strategy to construct a stable solid electrolyte interphase (SEI) on the Mg anode, which necessitates meticulous consideration of electrolyte chemistry and substantial quantities of additives. Notably, the electric double layer (EDL) adjacent to anode is pivotal role in SEI formation yet remains understudied. In this study, we propose a novel self-assembled monolayer (SAM) strategy by utilizing (trifluoromethyl)trimethylsilane (TFTMS, only 2 vol %, 1.4 mol %, 0.135 mol L −1 ), a low DN but strong Mg metal absorbability through electron-withdrawing groups(−CF 3 ), to modulate the complex structure of the Helmholtz absorption plane. Through dipole-dipole interaction between the electronegative fluorine (−CF 3 of TFTMS) and electropositive hydrogen (−CH 3 /−CH 2 of solvents), TFTMS weakens solvent-Mg 2+ coordination and thus enhances anion-Mg 2+ interaction, inducing a stable and dense SEI with superior electronic insulation to realize horizontal Mg plating/stripping. Consequently, the designed electrolytes enable the symmetric cells to cycle stable for up to 1000 hours and reversible Mg plating/stripping under 5 mA cm −2 , they show favorable compatibility with various cathodes. More importantly, the SAM strategy has good generality in other electrolyte systems, demonstrating a simple and effective route to promote the practical application of rechargeable magnesium battery.}, archive = {J_ANGEW}, author = {Zhengqing Fan and Wanyu Zhao and Shang Shi and Mengyuan Zhou and Jiayi Li and Yuan Liu and Zhenghui Pan and Xiaowei Yang}, doi = {10.1002/anie.202416582}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416582}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating electric double layer via self-assembled monolayer for stable Solid/Electrolyte interphase on mg metal anode}, volume = {64}, year = {2025}, }
• (2025). Interception of alkynyl tetracoordinate borons with sulfur electrophiles beyond the zweifel pathway. ANGEW, 64(4), e202416579. (www)

  @article{ , abstract = {Zweifel reaction is a powerful strategy to construct olefins from alkenyl tetracoordinate borons in organoboron chemistry, however, it usually only involves one functional group migration and then undergoes an elimination process affording alkenes or alkynes exclusively. Herein, we disclose several intriguing interception of alkynyl tetracoordinate borons with sulfur electrophiles. Wherein, the substituted benzothiophenes are accessed by consecutive 1,2-migrations and intramolecular electrophilic substitution, meanwhile, the challenging and elusive five/four-membered boracycles are easily assembled, and an approach to alkenyl sulfides with good stereoselectivity was developed as well. Moreover, by adding readily available deuterium sources, the tetrasubstituted deuterated alkenyl sulfides with high deuteration rates are constructed. These protocols not only improve atom economy by prohibiting the elimination of Zweifel intermediate, but also enrich the reaction modes of alkynyl tetracoordinate borons achieving versatile value-added sulfur-containing molecules. Mechanistic investigations illustrate that dichlorosulfoxide (SOCl 2 ) and dialkylaminosulfur trifluoride-type reagents (DAST-type) as surfur sources could promote dual 1,2-aryl migration of alkynyl tetracoordinate borons, which are distinct from traditional Zweifel reaction, and the regulation of steric hindrance could also make four-membered boracycles and alkenyl sulfides feasible. And these transformations feature novel reaction modes and unusual reaction mechanisms with valuable products in high efficiency.}, archive = {J_ANGEW}, author = {Xingxing Ma and Yuanbiao An and Luo Li and Meihui Cai and Qiuling Song}, doi = {10.1002/anie.202416579}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interception of alkynyl tetracoordinate borons with sulfur electrophiles beyond the zweifel pathway}, volume = {64}, year = {2025}, }
• (2025). Two-phase perchlorate activation enabled by a dinuclear fe-NHC (N-heterocyclic carbene) complex. ANGEW, 64(4), e202416578. (www)

  @article{ , abstract = {Perchlorate, initially regarded as a weakly coordinating counterion rather than a reactive oxidizing reagent due to its kinetic stability, has garnered attention for its potential in microbial systems. Under anaerobic conditions, microbes utilize perchlorate as a terminal oxidant for methane oxidation, involving two distinct stages: extraction and release of oxidizing ability. This two-phase activation process necessitates the collaborative action of multiple enzymes, a phenomenon not extensively explored in artificial systems. To address this issue, a dinuclear Fe-NHC (N-heterocyclic carbene) complex 1 was designed to enable the two-phase activation of perchlorate. Initially, complex 1 extracts the oxidative potential of perchlorate, leading to the formation of Fe(III)-O−Fe(III) complex 2 as the oxidation product. Subsequently, the extracted oxidative potential can be released by photolyzing a mixture of complex 2 and 9,10-dihydroanthracene. In contrast to the commonly observed selectivity, the homocoupling product 5 was identified as the major product in this C−H activation reaction. Further, a catalytic C−H activation reaction is initiated under anaerobic conditions to selectively form the C−C coupling product, achieving the complete two-phase activation of perchlorate using a single artificial catalyst. This work provides a new paradigm for constructing biomimetic anaerobic oxidation using kinetically inert high-valent oxygenated acid anions as oxidants.}, archive = {J_ANGEW}, author = {Xinyu Xu and Kai Hua and Ming-Tian Zhang}, doi = {10.1002/anie.202416578}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-phase perchlorate activation enabled by a dinuclear fe-NHC (N-heterocyclic carbene) complex}, volume = {64}, year = {2025}, }
• (2025). Mineralizing biofilm towards sustainable conversion of plastic wastes to hydrogen. ANGEW, 64(4), e202416577. (www)

  @article{ , abstract = {The integration of inorganic materials with biological machinery to convert plastics into fuels offers a promising strategy to alleviate environmental pollution and energy crisis. Herein, we develop a type of hybrid living material via biomineralization of CdS onto Shewanella oneidensis -based biofilm, which is capable of sustainable hydrogen production from poly(lactic acid) (PLA) wastes under daylight. We reveal that the formed biofilm microstructure provides an independent anaerobic microenvironment that simultaneously supports cellular viability, maintains hydrogenase activity, and preserves the functional stability of CdS, giving rise to the efficient plastic-to-hydrogen conversion efficiency as high as 3751 μmol H 2 g-1 PLA. Besides, by genetically engineering transmembrane pili conduit and incorporating conductive nanomaterials to strengthen the electron transfer across cellular interface and biofilm matrices, we show that the conversion efficiency is further enhanced to 5862 μmol H 2 g-1 PLA. Significantly, we exhibit that a long-term sustainable plastic-to-hydrogen conversion of 63 d could be achieved by periodically replenishing PLA wastes. Overall, by the synergistic integration of biotic-abiotic characteristics the developed biofilm-based biomineralized hybrid living material is anticipated to provide a new platform toward the efficient conversion of plastic wastes into valuable fuels, and bridge the gap between environmental contamination and green energy production.}, archive = {J_ANGEW}, author = {Baoyuan Li and Zhijun Xu and Ruifang Wang and Rui Nie and Zhengyu Tao and Xin Huang}, doi = {10.1002/anie.202416577}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416577}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mineralizing biofilm towards sustainable conversion of plastic wastes to hydrogen}, volume = {64}, year = {2025}, }
• (2025). Biocatalytic desymmetrization for the atroposelective synthesis of axially chiral biaryls using an engineered imine reductase. ANGEW, 64(4), e202416569. (www)

  @article{ , abstract = {The enzymatic atroposelective synthesis of biaryl compounds is relatively rare, despite considerable attention received by biocatalysis in the academic and industrial sectors. Imine reductases (IREDs) are an important class of enzymes that have been applied in the asymmetric synthesis of chiral amine building blocks. In this study, two IREDs (IR140 and IR189) were identified to catalyze the efficient desymmetrization of biaryls utilizing various amine donors. Further protein engineering enabled the identification of variants (IR189 M8–M9 and IR189 M13–M14) that are able to catalyze the formation of both ( R ) and ( S ) atropisomers in excellent yields and atroposelectivities (24 examples, up to 99 % ee and yield). The absolute configuration and rotational barriers were confirmed, and the reactions were readily scaled up to allow isolation of the atropisomeric product in 99 % ee and 82 % yield. The optically pure biaryl amines were further derivatized into various synthetically useful atropisomers. To shed light on the molecular recognition mechanisms, molecular dynamics (MD) simulations were performed, offering plausible explanations for the improved atroposelectivity and enzymatic activity. The current strategy expands the scope of the IRED-catalyzed synthesis of axially chiral biaryl amines, contributing significantly to the field of atroposelective biocatalysis.}, archive = {J_ANGEW}, author = {Pengpeng Zhang and Bo Yuan and Junkuan Li and Congcong Li and Jiaxin Guo and Bowen Zhang and Ge Qu and Hao Su and Nicholas J. Turner and Zhoutong Sun}, doi = {10.1002/anie.202416569}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416569}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Biocatalytic desymmetrization for the atroposelective synthesis of axially chiral biaryls using an engineered imine reductase}, volume = {64}, year = {2025}, }
• (2025). Ferroelectric dipoles tailoring solid-electrolyte-interphase chemistry to enable reversible lithium metal batteries. ANGEW, 64(4), e202416565. (www)

  @article{ , abstract = {Solid-electrolyte interphase (SEI) plays a decisive role in building reliable Li metal batteries. However, the scarcity of anions in Helmholtz layer (HL) caused by electrostatic repulsion usually leads to the inferior SEI derived from solvents, resulting in dendrites and ‘dead’ Li. Therefore, regulating the distribution of anions in electric double layer (EDL) and continuously introducing more anions into HL to tailor anions-derived SEI is crucial for achieving stable Li plating/stripping. Herein, by jointly utilizing the controlled defects of reduced graphene oxide (rGO) and the oriented dipoles of ferroelectric BaTiO 3 (BTO), the rGO-BTO composite layer sustainedly brings more TFSI − and NO 3 − into anion-defecient HL, promoting favorable decomposition of anions and guiding the generation of robust and fast-Li + -transport SEI containing more inorganics LiF and Li 3 N species. Thus, the resulting Li deposit shows smooth and dense morphologies without dendrites, leading to high average Coulombic efficiency. The Li//Cu@rGO-BTO (10 mAh cm −2 plated Li) cell exhibits an enhanced Li plating/stripping stability (2700 h) and a higher rate capability. The LiFePO 4 full cell (N/P≈6.3) using rGO-BTO displays an enhanced capacity retention (82.0 % @ 430 cycles). This work provides a new insight on the construction of robust SEI by regulating the distribution of anions within EDL.}, archive = {J_ANGEW}, author = {Baolei Xu and Chunxiao Zhang and Wenran Wang and Hai Zhu and Li Ma and Meiyu Wang and Chaoping Liang and Liangjun Zhou and Li Wang and Libao Chen and Douglas G. Ivey and Weifeng Wei}, doi = {10.1002/anie.202416565}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416565}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ferroelectric dipoles tailoring solid-electrolyte-interphase chemistry to enable reversible lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Unravelling the crucial of spatial al distribution to realize precise alkali-treatment for target acid-catalyzed reactions. ANGEW, 64(4), e202416564. (www)

  @article{ , abstract = {Constructing mesoporous structure within zeolites by alkali-treatment is an effective protocol to improve their diffusion properties. However, undesirable changes in Brönsted acid site (BAS) densities always offset this advantage in acid-catalyzed reactions. In this context, the crucial roles of spatial aluminum (Al) distribution were unraveled during alkali-treatment of MFI zeolite and the desirable BAS density was achieved in obtained hierarchical samples for the target reactions. Various characterization methods, particularly the multiple one- and two-dimensional magic-angle spinning (MAS) NMR techniques, were performed to track the alkali-treatment processes. For the sample with a more uniform spatial Al distribution, more tetrahedral Al sites would fall off and migrate around the Si-OH in zeolite as Al(OH) 4 − . Those re-deposited Al(OH) 4 − sites were easily transformed into NMR-invisible Al sites during the calcination process, which contributed negligibly to both Brönsted and Lewis acidities, thus being referred to “acid-free” Al species. While most tetrahedral Al sites were preserved after the alkali-treatment of sample with non-uniform Al distribution and the BAS density gradually increased with treatment time. According to the requirements of typical acid-catalyzed reactions, such as catalytic cracking of 1,3,5-triisopropylbenzene and methanol-to-olefins, the desired hierarchical zeolite catalysts were developed by matching the amounts of extracted Si and generated “acid-free” Al during the precise alkali-treatment.}, archive = {J_ANGEW}, author = {Junjie Li and Huihui Chen and Wen Liu and Yuchun Zhi and Na Ta and Sujuan Xie and Longya Xu and Xiujie Li and Xiangxue Zhu and Shutao Xu}, doi = {10.1002/anie.202416564}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416564}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unravelling the crucial of spatial al distribution to realize precise alkali-treatment for target acid-catalyzed reactions}, volume = {64}, year = {2025}, }
• (2025). A supramolecular approach to engineering living cells with enzymes for adaptive and recyclable cascade synthesis. ANGEW, 64(4), e202416556. (www)

  @article{ , abstract = {Biocatalytic transformation in nature is inherently dynamic, spontaneous, and adaptive, enabling complex chemical synthesis and metabolism. These processes often involve supramolecular recognition among cells, enzymes, and biomacromolecules, far surpassing the capabilities of isolated cells and enzymes used in industrial synthesis. Inspired by nature, here we design a supramolecular approach to equip living cells with these capacities, enabling recyclable, efficient cascade reactions. Our two-step “plug-and-play” methodology begins by coating Escherichia coli cells with guest-containing polymers (SupraBAC) via supramolecular charge interactions, followed by the introduction of β-cyclodextrin-functionalized host enzymes through host-guest chemistry, creating a robust cell-enzyme complex. This supramolecular coating not only protects cells from various stresses, such as UV radiation, heat, and organic solvents, but also facilitates the overexpression of intracellular enzymes and the attachment of extracellular enzymes within and on SupraBAC. This combination results in efficient multienzyme cascade synthesis, enabling two- and three-step reactions in one pot. Importantly, the multienzyme system can be recycled up to five times without significant loss of activity. Our findings introduce a versatile, adaptive supramolecular coating for whole-cell catalysts, offering a sustainable and efficient solution for complex synthesis in both chemistry and industrial biotechnology.}, archive = {J_ANGEW}, author = {Shan Wang and René Hübner and Henrik Karring and Vasco F. Batista and Changzhu Wu}, doi = {10.1002/anie.202416556}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416556}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A supramolecular approach to engineering living cells with enzymes for adaptive and recyclable cascade synthesis}, volume = {64}, year = {2025}, }
• (2025). Fast production of covalent organic frameworks for covalent enzyme immobilization with boosted enzymatic catalysis by solar-driven photothermal effect. ANGEW, 64(4), e202416550. (www)

  @article{ , abstract = {Developing new enzyme-immobilization systems to stabilize their dynamic structures and meanwhile enhance their catalytic activity is of great significance but very challenging. Herein, we design and fabricate a class of robust mesoporous covalent organic frameworks (COFs) via Michael addition-elimination reaction. It is found that highly crystalline COFs can be produced in 10 min, which is attributed to the promoting effect of the intramolecular hydrogen bond activation. The COFs rich in hydroxyl groups can be facilely post-modified by epibromohydrin to covalently immobilize enzymes with both high loading and activity. Furthermore, we create a solar-driven photothermal-promoted strategy by introducing photoactive azo groups to COF carriers, which can boost the enzyme catalytic performance (lipase) with much higher conversion of various racemic substrates and chiral resolution upon solar light irradiation. The heterogeneous biocatalysts also demonstrate exceptional reusability and stability. This work provides a green and energy-efficient approach to facilitate the scale application of enzyme-immobilized biocatalysts.}, archive = {J_ANGEW}, author = {Liqin Hao and Qianqian Zhu and Xueling Qiao and Qiongyu Shi and Yujie Liu and Tonghai Wang and En Lin and Peng Cheng and Zhenjie Zhang and Yao Chen}, doi = {10.1002/anie.202416550}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fast production of covalent organic frameworks for covalent enzyme immobilization with boosted enzymatic catalysis by solar-driven photothermal effect}, volume = {64}, year = {2025}, }
• (2025). Polar order in a fluid like ferroelectric with a tilted lamellar structure – Observation of a polar smectic c (SmCP) phase. ANGEW, 64(4), e202416545. (www)

  @article{ , abstract = {The discovery of fluid states of matter with spontaneous bulk polar order is appreciated as a major discovery in the fields of soft matter and liquid crystals. Typically, this manifests as polar order superimposed atop conventional phase structures and is thus far limited to orthogonal phase types. Here we report a family of materials which exhibit a previously unseen state of matter which we conclude is a polar smectic C phase, and so we term it SmC P . The spontaneous polarisation of the SmC P phase is over two orders of magnitude larger than that found in conventional ferroelectric SmC phase of chiral materials used in some LCD devices. Fully atomistic molecular dynamics simulations faithfully and spontaneously reproduce the proposed structure and associated bulk properties; comparison of experimental and simulated X-ray scattering patterns shows excellent agreement. The materials disclosed here have significantly smaller dipole moments than typical polar liquid crystals such as RM734 which suggests the role of molecular electrical polarity in generating polar order is perhaps overstated, a view supported by consideration of other molecular systems.}, archive = {J_ANGEW}, author = {Jordan Hobbs and Calum J. Gibb and Damian Pociecha and Jadwiga Szydłowska and Ewa Górecka and Richard J. Mandle}, doi = {10.1002/anie.202416545}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416545}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polar order in a fluid like ferroelectric with a tilted lamellar structure – Observation of a polar smectic c (SmCP) phase}, volume = {64}, year = {2025}, }
• (2025). Clay nanosheet-based nanocomposite supramolecular hydrogel enabling rapid, reversible phase transition only with visible light. ANGEW, 64(4), e202416541. (www)

  @article{ , abstract = {High mechanical properties and rapid sol/gel phase transition are mutually exclusive in the hydrogels reported to date, most likely because the 3D crosslinked networks of mechanically robust hydrogels comprise bundled thick fibers that are not rapidly dissociable or formable. Herein, we report a visible light-responsive hydrogel that showed a rapid, reversible sol/gel phase transition despite its relatively high mechanical properties (storage modulus ~10 3 Pa). To construct its 3D crosslinked network, we used a design strategy analogous to that employed for our highly water-rich yet mechanically robust nanocomposite supramolecular hydrogel (“aqua material”). In this case, multiple poly(ethylene glycol) chains carrying ortho -tetramethoxyazobenzene termini ( Azo PEG) were noncovalently crosslinked by clay nanosheets (CNSs) with surface-immobilized β -cyclodextrin units using their seven guanidinium ion (Gu + ) pendants ( Gu CD) via a multivalent salt-bridge. When exposed to visible light at 625 and 450 nm, the azobenzene termini isomerized from trans -to- cis and cis -to- trans , respectively, and were detached from and attached to the surface-immobilized Gu CD units. The advantage of this CNS-based nanocomposite supramolecular system is its simple 3D network structure, which forms and breaks rapidly without slow chain entangling and disentangling processes.}, archive = {J_ANGEW}, author = {Ye Fu and Kou Okuro and Jiandong Ding and Takuzo Aida}, doi = {10.1002/anie.202416541}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416541}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Clay nanosheet-based nanocomposite supramolecular hydrogel enabling rapid, reversible phase transition only with visible light}, volume = {64}, year = {2025}, }
• (2025). CO-tolerant heterogeneous ruthenium catalysts for efficient formic acid dehydrogenation. ANGEW, 64(4), e202416530. (www)

  @article{ , abstract = {The development of improved and less costly catalysts for dehydrogenation of formic acid (HCOOH) is of general interest for renewable energy technologies involving hydrogen storage and release. Theoretical calculations reveal that ruthenium (Ru) nanoparticles supported on nitrogen-doped carbon should be appropriate catalysts for such transformations. It is predicted that nitrogen doping significantly decreases the formation of CO, but at the same time increases CO tolerance of the catalysts. To prove these hypotheses heterogeneous ruthenium catalysts supported on porous nitrogen-doped carbon (Rux/CN) with hierarchical structure were synthesized using carbon nitride (C 3 N 4 ) as template and phenanthroline (Phen) as ligand. Experimental tests in HCOOH dehydrogenation revealed that the optimal catalyst Ru7/CN exhibited good thermal stability at 140 °C and a high turnover frequency (TOF >1300 h −1 ), which is more than one order of magnitude higher than that of the commercial Ru5/C catalyst.}, archive = {J_ANGEW}, author = {Guangxin Xue and Yueyue Jiao and Xiang Li and Tian Lin and Caoyu Yang and Sihan Chen and Zupeng Chen and Haifeng Qi and Stephan Bartling and Haijun Jiao and Henrik Junge and Matthias Beller}, doi = {10.1002/anie.202416530}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416530}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CO-tolerant heterogeneous ruthenium catalysts for efficient formic acid dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). NHC-catalyzed aldimine umpolung/6π-electrocyclization cascade to access tetracyclic dihydrochromeno indoles. ANGEW, 64(4), e202416519. (www)

  @article{ , abstract = {The umpolung of aldimines using N-heterocyclic carbenes (NHCs) is less explored compared to the established polarity reversal of aldehydes. Described herein is an NHC-catalyzed imine umpolung /6π-electrocyclization cascade, which leads to the atom- and pot-economic synthesis of biologically important dihydrochromeno indoles. For the first time, the nucleophilic aza-Breslow intermediates have been intercepted with unactivated alkynes. Preliminary mechanistic and DFT studies shed light on the role of the phenolic −OH moiety in promoting the addition of the aza-Breslow intermediate to the unactivated alkyne via an intramolecular proton transfer in a stepwise manner. DFT studies also support the regioselectivity preference for the 5- exo-dig cyclization pathway, leading to the exclusive formation of the indole products. Moreover, a comparison of Gibbs free energies provides insight into a thermodynamically preferred 6π-electrocyclization over a competing oxa-Michael pathway. Further, this strategy is applied to the formal synthesis of a Hepatitis C Virus (HCV) NS5A inhibitor in a step-economical method.}, archive = {J_ANGEW}, author = {Rohan Chandra Das and Priyanshu Gupta and Sukriyo Chakraborty and Garima Jindal and Akkattu T. Biju}, doi = {10.1002/anie.202416519}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416519}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NHC-catalyzed aldimine umpolung/6π-electrocyclization cascade to access tetracyclic dihydrochromeno indoles}, volume = {64}, year = {2025}, }
• (2025). De(sulfon)amidative cyclization: The synthesis of dibenzolactams and dibenzosultams for organic light emitting diode materials. ANGEW, 64(4), e202416518. (www)

  @article{ , abstract = {This study addresses a challenge in organic synthetic chemistry: the direct cleavage of amide bonds, which is typically hampered by the thermodynamic stability of the C(Ar)−C(acyl) bond. Previous methods often rely on “CO” extrusion-jointing transition metal-catalyzed process and require activated tertiary amides, limiting their applicability due to incompatibility with reactive functional groups such as halogens. Herein, we report a transition metal-free approach for the deamidative cyclization of biaryl diamides via a radical process, yielding dibenzolactam derivatives. Along this line, we have developed the desulfonamidative cyclization of biaryl disulfonamides to produce dibenzosultams through direct nucleophilic aromatic substitution, demonstrating high selectivity for unsymmetrical structures. Additionally, unsymmetrical sulfamoyl biaryl amides, containing both amide and sulfonamide functionalities, can selectively undergo desulfonamidative coupling with the amide to form dibenzolactams, which offers a complementary synthetic pathway to unsymmetric dibenzolactams. These protocols exhibit excellent compatibility with reactive functional groups, including halogens, providing an innovative synthetic toolbox for the development of thermally activated delayed fluorescence (TADF) materials used in organic light emitting diodes (OLEDs). DMAC-PDO, incorporating a dibenzolactam as the acceptor unit, serves as an efficient blue TADF emitter with a maximum external quantum efficiency (EQE max ) of 23.4 %.}, archive = {J_ANGEW}, author = {Anping Luo and Zhijie Li and Haohua Chen and Ya Wang and Xiaoyu Liu and Zhengyang Bin and Yudong Yang and Jingsong You}, doi = {10.1002/anie.202416518}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416518}, shortjournal = {Angew. Chem. Int. Edit.}, title = {De(sulfon)amidative cyclization: The synthesis of dibenzolactams and dibenzosultams for organic light emitting diode materials}, volume = {64}, year = {2025}, }
• (2025). Synthesis and structure determination by 3D electron diffraction of the extra-large pore zeolite ITQ-70. ANGEW, 64(4), e202416515. (www)

  @article{ , abstract = {In this study, we present the synthesis, characterization, and structural analysis of a novel zeolite, ITQ-70, using 3D electron diffraction. This unique material was synthesized under alkaline conditions, employing tetrakis(diethylamino)phosphonium as an organic structure-directing agent, leading to the formation of a pure silica zeolite. ITQ-70 is distinguished by its extra-large pore apertures, which extend along all three axes and intersect one to the other. A notable feature of this zeolite is the presence of structurally ordered defects in very high concentrations (38 % of the silicon atoms). As a result, ITQ-70 exhibits the lowest framework density (10.0 T/1000 Å 3 ) ever reported for any zeolite except RWY (7.6 T/1000 Å 3 ), which contains sulfur instead of oxygen connecting T-atoms.}, archive = {J_ANGEW}, author = {Juan I. Tirado and Andrés Sala and Antonio Bordes and Partha Pratim Das and Lukáš Palatinus and Stavros Nicolopoulos and Jose L. Jordá and Alejandro Vidal-Moya and Teresa Blasco and German Sastre and Susana Valencia and Fernando Rey}, doi = {10.1002/anie.202416515}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416515}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and structure determination by 3D electron diffraction of the extra-large pore zeolite ITQ-70}, volume = {64}, year = {2025}, }
• (2025). A Knowledge–Data dual-driven framework for predicting the molecular properties of rechargeable battery electrolytes. ANGEW, 64(4), e202416506. (www)

  @article{ , abstract = {Developing rechargeable batteries that operate within a wide temperature range and possess high safety has become necessary with increasing demands. Rapid and accurate assessment of the melting points (MPs), boiling points (BPs), and flash points (FPs) of electrolyte molecules is essential for expediting battery development. Herein, we introduce Knowledge-based electrolyte Property prediction Integration (KPI), a knowledge–data dual-driven framework for molecular property prediction of electrolytes. Initially, the KPI collects molecular structures and properties, and then automatically organizes them into structured datasets. Subsequently, interpretable machine learning further explores the structure–property relationships of molecules from a microscopic perspective. Finally, by embedding the discovered knowledge into property prediction models, the KPI achieved very low mean absolute errors of 10.4, 4.6, and 4.8 K for MP, BP, and FP predictions, respectively. The KPI reached state-of-the-art results in 18 out of 20 datasets. Utilizing molecular neighbor search and high-throughput screening, 15 and 14 promising molecules, with and without Chemical Abstracts Service Registry Number, respectively, were predicted for wide-temperature-range and high-safety batteries. The KPI not only accurately predicts molecular properties and deepens the understanding of structure–property relationships but also serves as an efficient framework for integrating artificial intelligence and domain knowledge.}, archive = {J_ANGEW}, author = {Yu-Chen Gao and Yu-Hang Yuan and Suozhi Huang and Nan Yao and Legeng Yu and Yao-Peng Chen and Qiang Zhang and Xiang Chen}, doi = {10.1002/anie.202416506}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416506}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A Knowledge–Data dual-driven framework for predicting the molecular properties of rechargeable battery electrolytes}, volume = {64}, year = {2025}, }
• (2025). Evolution of frustrated coordination in eutectic electrolyte driven by ligand asymmetry toward high-performance zinc batteries. ANGEW, 64(4), e202416482. (www)

  @article{ , abstract = {Eutectic electrolytes hold promise for aqueous zinc metal batteries in sustainable energy storage chemistries, yet improvement from perspective of molecule configurational engineering are ambiguous. Herein, we propose design strategy of increasing asymmetric molecular geometry in organic ligands to regulate frustrated coordination and disordered structure for eutectic electrolytes toward enhanced zinc metal batteries. The introduced asymmetry in eutectic component gives rise to relatively weak coordination strength and configurational disorder interaction among cation-anion-ligand, leading to suppressed local aggregation, steady eutectic phase and improved Zn 2+ diffusion kinetics. Such highly frustrated coordination state also enables disruption of hydrogen bonding network and reinforcement of anion participation, which results in confined side reactions, decreased water activity and the formation of inorganic-enriched solid electrolyte interphase. In comparison to highly symmetric ligands, asymmetric ligand-involved eutectic electrolytes with configurational disorder deliver high Coulombic efficiency of 99.4 %, stabilized Zn plating/stripping of 5000 h and impressive rate capability even under harsh conditions such as small N/P, low temperature. The rationale in this work advances the deep understanding of asymmetric molecular engineering in eutectic electrolytes and showcases suitability of frustrated coordination to achieve high-performance zinc metal batteries.}, archive = {J_ANGEW}, author = {Wenjing Deng and Zhiping Deng and Xuzi Zhang and Yimei Chen and Renfei Feng and Ge Li and Xiaolei Wang}, doi = {10.1002/anie.202416482}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416482}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evolution of frustrated coordination in eutectic electrolyte driven by ligand asymmetry toward high-performance zinc batteries}, volume = {64}, year = {2025}, }
• (2025). A strongly reducing sp2 carbon-conjugated covalent organic framework formed by N-heterocyclic carbene dimerization. ANGEW, 64(4), e202416480. (www)

  @article{ , abstract = {Covalent organic frameworks linked by carbon-carbon double bonds (C=C COFs) are an emerging class of crystalline, porous, and conjugated polymeric materials with potential applications in organic electronics, photocatalysis, and energy storage. Despite the rapidly growing interest in sp 2 carbon-conjugated COFs, only a small number of closely related condensation reactions have been successfully employed for their synthesis to date. Herein, we report the first example of a C=C COF, CORN-COF-1 (CORN=Cornell University), prepared by N -heterocyclic carbene (NHC) dimerization. In-depth characterization reveals that CORN-COF-1 possesses a two-dimensional layered structure and hexagonal guest-accessible pores decorated with a high density of strongly reducing tetraazafulvalene linkages. Exposure of CORN-COF-1 to tetracyanoethylene (TCNE, E 1/2 =0.13 V and −0.87 V vs. SCE) oxidizes the COF and encapsulates the radical anion TCNE⋅ − and the dianion TCNE 2− as guest molecules, as confirmed by spectroscopic and magnetic analysis. Notably, the reactive TCNE⋅ − radical anion, which generally dimerizes in the solid state, is uniquely stabilized within the pores of CORN-COF-1. Overall, our findings broaden the toolbox of reactions available for the synthesis of redox-active C=C COFs, paving the way for the design of novel materials.}, archive = {J_ANGEW}, author = {Tristan A. Pitt and Tyler J. Azbell and Jaehwan Kim and Zixiao Shi and David A. Muller and Matthew A. Addicoat and Phillip J. Milner}, doi = {10.1002/anie.202416480}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416480}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A strongly reducing sp2 carbon-conjugated covalent organic framework formed by N-heterocyclic carbene dimerization}, volume = {64}, year = {2025}, }
• (2025). Synthesis of functionalized cycloheptadienones starting from phenols and using a Rhodium/Boron asymmetric catalytic system. ANGEW, 64(4), e202416468. (www)

  @article{ , abstract = {Skeletal editing offers a unique route to assemble complex architectures from simple feedstocks that are otherwise difficult to obtain. However, the asymmetric version of skeletal editing has not been widely studied. Herein, we present a modular rhodium/boron asymmetric catalytic system that enables ring-expansion of phenols with cyclopropenes to synthesize highly functionalized cycloheptadienones in excellent chemo- and regioselectivities. This unique protocol features with low-catalyst loading, atom and step-economies, and mild neutral reaction conditions. Isotope-labelling experiments and DFT calculations have been conducted to reveal that boron reagent plays a vital role in the whole catalytic cycle.}, archive = {J_ANGEW}, author = {Jiabin Han and Yaxin Fan and Xiaoyan Yang and Yuanhao Zhu and Xuheng Zhang and Fukuan Zhang and Gefei Hao and Yaojia Jiang}, doi = {10.1002/anie.202416468}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416468}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of functionalized cycloheptadienones starting from phenols and using a Rhodium/Boron asymmetric catalytic system}, volume = {64}, year = {2025}, }
• (2025). F–π* back-bonding orbital induced by a lutetium-based conducting Metal–Organic framework promotes highly selective CO2-to-CH4 conversion at low potential. ANGEW, 64(4), e202416467. (www)

  @article{ , abstract = {The research on electrocatalytic carbon dioxide reduction (ECR) catalysts using renewable energy is particularly crucial in energy conversion studies, especially for viable hydrocarbon production. This study employs density functional theory calculations to screen a series of non-radioactive lanthanide two-dimensional metal–organic frameworks (MOFs) for product selectivity in ECR. Based on theoretical screening, our focus is on a lutetium (Lu)-based conducting MOF (Lu-HHTP), which exhibits a Faradaic efficiency of approximately 77 % for methane (CH 4 ) production and maintains a stable current density of −280 mA/cm 2 at −1.1 V vs. RHE. In situ electrochemical experiments and material characterization demonstrate that the Lu sites possess high coordination stability and structural recoverability during catalytic CO 2 reduction, attributed to the overlap between Lu′s f-orbitals and the π*-orbitals of the ligand O, and the formation of back bonding orbitals between the f-orbitals of Lu and the π* orbitals of CO contribute increasing CH 4 selectivity and lowering the potential. This study leverages rare-earth MOF-type materials, offering a novel approach to addressing low conductivity and stabilizing rare-earth materials, thereby establishing a theoretical framework for the conversion of linearly adsorbed *CO into hydrocarbons.}, archive = {J_ANGEW}, author = {Fuqing Yu and Guangyao Zhang and Minxing Shu and Hongming Wang}, doi = {10.1002/anie.202416467}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416467}, shortjournal = {Angew. Chem. Int. Edit.}, title = {F–π* back-bonding orbital induced by a lutetium-based conducting Metal–Organic framework promotes highly selective CO2-to-CH4 conversion at low potential}, volume = {64}, year = {2025}, }
• (2025). Modulating pore wall chemistry empowers sonodynamic activity of two-dimensional covalent organic framework heterojunctions for pro-oxidative nanotherapy. ANGEW, 64(4), e202416461. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have garnered growing interest in the field of biomedicine; however, their application in sonodynamic therapy remains underexplored due to limited understanding of their intrinsic activity and structure–property relationships. Here, we present a pore wall chemistry modulation strategy for empowering sonodynamic activity to two-dimensional (2D) COF heterojunctions through in situ growth of COFs on bismuth oxycarbonate nanosheets (B NSs). Compared to the negligible sonodynamic effects observed in the pristine B NSs, the 2D heterojunction with vinyl-decorated COF pore walls demonstrates a 3.6-fold enhancement in sonocatalytic singlet oxygen generation. This performance also significantly outperforms that of isoreticular COFs functionalized with methoxy or non-substituted groups. Mechanistic studies reveal that the vinyl groups in the B@COF (BC) heterojunction facilitate the separation and transfer of charge carriers while also enhancing the adsorption of oxygen molecules. Furthermore, peroxymonosulfate (PMS) loading into the porous COFs boosts the therapeutic efficacy of antitumor nanotherapy via sonocatalytic dual oxidative species generation. These findings underscore the critical role of pore wall chemistry in modulating the sonocatalytic properties of COFs, and advance the development of COF-based sonosensitizers for pro-oxidative applications.}, archive = {J_ANGEW}, author = {Ruohui Wu and Mengying Hua and Yanjia Lu and Liang Chen and Yu Chen and Zhongqian Hu}, doi = {10.1002/anie.202416461}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating pore wall chemistry empowers sonodynamic activity of two-dimensional covalent organic framework heterojunctions for pro-oxidative nanotherapy}, volume = {64}, year = {2025}, }
• (2025). Earth: An oxidative planet with limited atom resources and rich chemistry. ANGEW, 64(4), e202416459. (www)

  @article{ , abstract = {Humanity faces an unprecedented survival challenge: climate change, driven by the depletion of natural resources, excessive waste generation, and deforestation. Six out of nine planetary boundaries have been exceeded, signaling that Earth is far from a safe operating space for humanity. In this Viewpoint Article we explore three critical “atomic-molecular” challenges: Earth's limited atomic resources, its oxidative nature, and very rich chemistry. Addressing these requires a transformation in how we produce and consume, emphasizing sustainable practices aligned with the United Nations’ 17 goals. The advancement of science and technology has extended human life expectancy and improved quality of life. However, to ensure a sustainable future, we must move towards less oxidative chemical processes, incorporate CH 4 −CO 2 redox chemistry into the circular economy, and transition from a linear, fossil fuel-dependent economy to a circular bioeconomy. Reforestation and the recovery of degraded lands are essential, alongside the shift towards green and sustainable chemistry. Earth's dynamic chemistry is governed by the principles of thermodynamics and kinetics, but science alone is insufficient. Achieving global sustainability requires coordinated economic, political, and social decisions that recognize Earth's limited resources and oxidative nature. Together, these efforts will position humanity to meet the challenges of climate change and secure a sustainable future.}, archive = {J_ANGEW}, author = {Jairton Dupont and Pedro Lozano}, doi = {10.1002/anie.202416459}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416459}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Earth: An oxidative planet with limited atom resources and rich chemistry}, volume = {64}, year = {2025}, }
• (2025). A discrete four-stranded β-sheet through catenation of M2L2 Metal–Peptide rings. ANGEW, 64(4), e202416442. (www)

  @article{ , abstract = {Methods for precisely constructing a β-sheet assembly with number-defined strands in solution remains quite limited due to its intense aggregation property. Here, we report the precise construction of a four-stranded anti-parallel β-sheet by utilizing a non-covalent approach. This was achieved by folding and assembly of Ag + and a pentapeptide ( 1 ) with the Ala- D 3pa-Gly-3pa-Val (3pa: β-(3-pyridyl)-alanine) sequence, which was designed to form an interlocking Ag 2 ( 1 ) 2 ring through metal cross-linking of the side chains. NMR analyses and X-ray crystallographic studies characterized the structure of the discrete β-sheet assembly as well as the remarkable structural selectivity in terms of strands’ number, orientation and the sheet type.}, archive = {J_ANGEW}, author = {Eisuke Tsunekawa and Makoto Fujita and Tomohisa Sawada}, doi = {10.1002/anie.202416442}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416442}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A discrete four-stranded β-sheet through catenation of M2L2 Metal–Peptide rings}, volume = {64}, year = {2025}, }
• (2025). Unlocking oxetane potential: Modular synthetic platform for the concise synthesis of acyclic oligo-isoprenoids and terpenoids. ANGEW, 64(4), e202416441. (www)

  @article{ , abstract = {Terpenes occupy a unique place among the secondary metabolites due to their broad utility and extraordinary structural diversity. Their synthesis via polyene cyclization, either biomimetic or enzymatic, represents the cutting edge of modern synthetic chemistry. However, these endeavors have been inherently tied to the availability of natural and non-natural acyclic polyene starting materials. Herein, we report an oxetane-based platform for the modular construction of oxygenated polyolefins with precise geometric control. This “tail-to head” iterative method leverages the site-selective cross-metathesis of terminal olefins to form an alkylidene oxetane moiety and the regioselective ring opening of alkenyl-oxetanes for chain elongation. In addition, the unique and peculiar propensity of alkylidene oxetane fragment in various reactions was also revealed and exploited for site-selective functionalization, cyclization, and as a protecting group in polyenes.}, archive = {J_ANGEW}, author = {Krisztián Albitz and Sára Tóth and Dániel Csókás and Tibor Soós}, doi = {10.1002/anie.202416441}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416441}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking oxetane potential: Modular synthetic platform for the concise synthesis of acyclic oligo-isoprenoids and terpenoids}, volume = {64}, year = {2025}, }
• (2025). A synthetic oligosaccharide resembling francisella tularensis strain 15 O-antigen capsular polysaccharide as a lead for tularemia diagnostics and therapeutics. ANGEW, 64(4), e202416432. (www)

  @article{ , abstract = {Francisella tularensis , a category A bioterrorism agent, causes tularemia in many animal species. F. tularensis subspecies tularensis (type A) and holarctica (type B) are mainly responsible for human tularemia. The high mortality rate of 30–60 % caused by F. tularensis subspecies tularensis if left untreated and the aerosol dispersal renders this pathogen a dangerous bioagent. While a live attenuated vaccine strain (LVS) of F. tularensis type B does not provide sufficient protection against all forms of tularemia infections, a significant level of protection against F. tularensis has been observed for both passive and active immunization of mice with isolated O -antigen capsular polysaccharide. Well-defined, synthetic oligosaccharides offer an alternative approach towards the development of glycoconjugate vaccines. To identify diagnostics and therapeutics leads against tularemia, a collection of F. tularensis strain 15 O -antigen capsular polysaccharide epitopes were chemically synthesized. Glycan microarrays containing synthetic glycans were used to analyze the sera of tularemia-infected and non-infected animals and revealed the presence of IgG antibodies against the glycans. Two disaccharide ( 13 and 18 ), both bearing a unique formamido moiety, were identified as minimal glycan epitopes for antibody binding. These epitopes are the starting point for the development of diagnostics and therapeutics against tularemia.}, archive = {J_ANGEW}, author = {Kabita Pradhan and Emelie E. Reuber and Eric T. Sletten and Herbert Tomaso and Peter H. Seeberger}, doi = {10.1002/anie.202416432}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416432}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A synthetic oligosaccharide resembling francisella tularensis strain 15 O-antigen capsular polysaccharide as a lead for tularemia diagnostics and therapeutics}, volume = {64}, year = {2025}, }
• (2025). Antimony component schottky nanoheterojunctions as ultrasound-heightened pyroptosis initiators for sonocatalytic immunotherapy. ANGEW, 64(4), e202416426. (www)

  @article{ , abstract = {Pyroptosis, an inflammatory modality of programmed cell death associated with the immune response, can be initiated by bioactive ions and reactive oxygen species (ROS). However, bioactive ion-induced pyroptosis lacks specificity, and further exploration of other ions that can induce pyroptosis in cancer cells is needed. Sonocatalytic therapy (SCT) holds promise due to its exceptional penetration depth; however, the rapid recombination of electron-hole (e − -h + ) pairs and the complex tumor microenvironment (TME) impede its broader application. Herein, we discovered that antimony (Sb)-based nanomaterials induced pyroptosis in cancer cells. Therefore, Schottky heterojunctions containing Sb component (Sb 2 Se 3 @Pt) were effectively designed and constructed via in situ growth of platinum (Pt) nanoparticles (NPs) on Sb 2 Se 3 semiconductor with narrow band gaps, which were utilized as US-heightened pyroptosis initiators to induce highly effective pyroptosis in cancer cells to boost SCT-immunotherapy. Under US irradiation, excited electrons were transferred from Sb 2 Se 3 nanorods (NRs) to the co-catalyst Pt via Schottky junctions, and band bending effectively prevented electron backflow and achieved efficient ROS generation. Moreover, the pores oxidized and depleted the overexpressed GSH in the TME, potentially amplifying ROS generation. The biological effects of the Sb 2 Se 3 @Pt nanoheterojunction itself combined with the sonocatalytic amplification of oxidative stress significantly induced Caspase-1/GSDMD-dependent pyroptosis in cancer cells. Therefore, SCT treatment with Sb 2 Se 3 @Pt not only effectively restrained tumor proliferation but also induced potent immune memory responses and suppressed tumor recurrence. Furthermore, the integration of this innovative strategy with immune checkpoint blockade (ICB) treatment elicited a systemic immune response, effectively augmenting therapeutic effects and impeding the growth of abscopal tumors. Overall, this study provides further opportunities to explore pyroptosis-mediated SCT-immunotherapy.}, archive = {J_ANGEW}, author = {Jihu Nie and Nailin Yang and Shumin Sun and Li Wang and Zifan Pei and Jie Wu and Qiao Yu and Zhihui Han and Youdong Chen and Liang Cheng}, doi = {10.1002/anie.202416426}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antimony component schottky nanoheterojunctions as ultrasound-heightened pyroptosis initiators for sonocatalytic immunotherapy}, volume = {64}, year = {2025}, }
• (2025). Fluorescence modulation through the inverted energy gap law in triply N−B←N-containing windmill-shaped triazines. ANGEW, 64(4), e202416425. (www)

  @article{ , abstract = {A series of windmill-shape heterocyclic molecules containing three N−B←N units, TBN and its derivatives, with quasi-planar C 3 symmetric backbone, are synthesized. The parent TBN exhibits a strongly allowed, doubly degenerate lowest excited state but suffers from very low fluorescence, due to very fast nonradiative decay rate through a conical intersection (CI) as revealed by femtosecond transient absorption spectroscopy and quantum-chemical calculations. Introducing peripheral phenyl- or thienyl-groups (Ph-TBN or Th-TBN) induces pronounced bathochromic shifts and enhances fluorescence, which is beneficial from inhibited nonradiative pathway by the increased energy barriers to access the CI at excited state. The understanding of this rather uncommon behaviour may open routes for the design of novel fluorescence materials.}, archive = {J_ANGEW}, author = {Yi Feng and Liangxuan Wang and Hongcheng Gao and Jiadong Zhou and Matthias Stolte and Honglin Qiu and Linlin Liu and Victor Adebayo and Martial Boggio-Pasqua and Frank Würthner and Johannes Gierschner and Zengqi Xie}, doi = {10.1002/anie.202416425}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416425}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fluorescence modulation through the inverted energy gap law in triply N−B←N-containing windmill-shaped triazines}, volume = {64}, year = {2025}, }
• (2025). Light-activated gene expression system using a caging-group-free photoactivatable dye. ANGEW, 64(4), e202416420. (www)

  @article{ , abstract = {Optical regulation of transcription using chemical compounds is an effective strategy to manipulate gene expression spatiotemporally. Conventional caging approaches with photoremovable protecting groups may require intense UV-light exposure and release potentially toxic byproducts. To address these problems, here we developed a light-mediated transcriptional regulation system by combining a caging-group-free photoactivatable dye PaX 560 and a multidrug-binding transcriptional regulator QacR. The cationic dye generated from PaX 560 through traceless photoconversion bound QacR and reduced its repressor function, resulting in transcriptional activation. Importantly, this system allowed transcriptional activation with a large dynamic range under mild visible light exposure and simultaneous detection of the state of the photoactivated effector. This module was integrated into the T7 RNA polymerase expression system to demonstrate light-activated transcription in vitro and in living cells.}, archive = {J_ANGEW}, author = {Tatsuki Nonomura and Masafumi Minoshima and Kazuya Kikuchi}, doi = {10.1002/anie.202416420}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416420}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-activated gene expression system using a caging-group-free photoactivatable dye}, volume = {64}, year = {2025}, }
• (2025). Constructing unsaturated ru atom arrays confined in mn oxides to boost neutral water reduction. ANGEW, 64(4), e202416402. (www)

  @article{ , abstract = {Recently, Ru single atoms supported on carbon nanomaterials have demonstrated ultrahigh activity for acid hydrogen evolution reaction (HER), however their neutral HER activity remains low due to the sluggish kinetics for both the water dissociation step to generate H* intermediates and subsequent H* recombination in neutral electrolytes. Here, we synthesize ordered low-coordinated Ru atom arrays confined in Mn oxides (i.e., Li 4 Mn 5 O 12 ) for concurrently boosting the water dissociation and H* recombination, thus achieving a 6-fold HER activity enhancement than commercial Pt/C in neutral media. Control experiments indicate that low-coordinated Ru atoms with strong affinity to oxygen atoms of water molecules facilitate the water dissociation to rapidly generate H*. More importantly, both electrochemical and theoretic results uncover that the array-like structure allows the activation of two water molecules on two adjacent Ru atoms for enabling direct H*−H* recombination via the Tafel step, while isolated Ru atoms can only activate water one by one for recombining H* via the sluggish Heyrovsky step. Clearly, this work paves new avenues to boosting the electrocatalytic activity by constructing ordered metal atoms assembles with controllable coordination environments.}, archive = {J_ANGEW}, author = {Qi Hu and Jianyong Cao and Shuai Qi and Na Meng and Jingwen Zhao and Tianchi Huang and Jiao You and Taiyu Liang and Chunyan Shang and Jiaying Yu and Hengpan Yang and Chuanxin He}, doi = {10.1002/anie.202416402}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing unsaturated ru atom arrays confined in mn oxides to boost neutral water reduction}, volume = {64}, year = {2025}, }
• (2025). Early detection of high-altitude hypoxic brain injury by in vivo electrochemistry. ANGEW, 64(4), e202416395. (www)

  @article{ , abstract = {High-altitude hypoxic brain injury (HHBI) is a kind of acute mountain sickness and the survival rate of patients with HHBI can be improved only if it is detected and treated at the early stage. However, limited by speediness and accuracy, it is still very difficult for most of current approaches to realize the early detection of HHBI. We propose herein a novel strategy for this goal based on spatiotemporal changes in the brain oxygen level. As revealed by in vivo electrochemistry, the characteristic changes of brain oxygen level under the high-altitude exposure are directly associated with the brain hypoxia status. Given brain hypoxia is the main pathogenesis of HHBI, the degree of HHBI can be diagnosed by the variation of brain oxygen, making the early detection of HHBI feasible. In addition, the risk of HHBI for mouse exposed to high-altitude hypoxia environments can be also prognosed days in advance.}, archive = {J_ANGEW}, author = {Xinru Li and Boyu Zhu and Nuo Dong and Ziyi Zhao and Jiayi Cao and Lin Zhou and Zhigang Gao and Bin Su}, doi = {10.1002/anie.202416395}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416395}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Early detection of high-altitude hypoxic brain injury by in vivo electrochemistry}, volume = {64}, year = {2025}, }
• (2025). Dual redox reactions of silver hexacyanoferrate prussian blue analogue enable superior electrochemical performance for zinc-ion storage**. ANGEW, 64(4), e202416392. (www)

  @article{ , abstract = {Prussian blue analogues (PBAs) have been employed as host materials of aqueous zinc-ion batteries (ZIBs), however, they suffer from low capacity and poor cycling stability due to limited electron transfer and the presence of interstitial water in PBAs. Herein, a vacancy and water-free silver hexacyanoferrate K 0.95 Ag 3.05 Fe(CN) 6 (AgHCF-3) was synthesized by adjusting the ratio of K and Ag in the framework. It offers nearly four electrons involving two sequential redox reactions, namely, Fe 3+ /Fe 2+ and Ag + /Ag 0 , to deliver a large capacity of 179.6 mAh g −1 at 20 mA g −1 with Coulomb efficiency of ~100 %. The Zn//AgHCF-3 cell delivers an estimated energy density of 200 Wh kg −1 , surpassing reported PBAs-based ZIBs. The formation of Ag 0 in the cycling process merits favorable rate performance of AgHCF-3 (156.4 mAh g −1 at 200 mA g −1 with 80.3 % capacity retention after 100 cycles). This investigation paves new pathways for high-capacity PBA cathodes.}, archive = {J_ANGEW}, author = {Liubin Wang and Ningbo Liu and Qiaqia Li and Xiaohan Wang and Jing Liu and Yinuo Xu and Zhiqiang Luo and Ning Zhang and Fujun Li}, doi = {10.1002/anie.202416392}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416392}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual redox reactions of silver hexacyanoferrate prussian blue analogue enable superior electrochemical performance for zinc-ion storage**}, volume = {64}, year = {2025}, }
• (2025). Enhancing the efficiency and stability of inverted perovskite solar cells and modules through top interface modification with N-type semiconductors. ANGEW, 64(4), e202416390. (www)

  @article{ , abstract = {The interface modification between perovskite and electron transport layer (ETL) plays a crucial role in achieving high performance inverted perovskite photovoltaics (i-PPVs). Herein, non-fullerene acceptors (NFAs), known as Y6-BO and Y7-BO, were utilized to modify the perovskite/ETL interface in i-PPVs. Non-polar solvent-soluble NFAs can effectively passivate surface defects without structural damage of the underlying perovskite films. Additionally, the improved phenyl-C61-butyric acid methyl ester (PCBM) ETL induced by NFAs modification significantly accelerates the electrons extraction. As a result, both Y6-BO and Y7-BO exhibit more effective interface modification effects compared to traditional PI molecules. The power conversion efficiency (PCE) of the inverted perovskite solar cell (i-PSC) modified with Y7-BO reaches 25.82 %. Moreover, the adoption of non-polar solvents and the superior semiconductor properties of Y7-BO molecules also enable perovskite solar modules (i-PSM) with effective areas of 50 cm 2 , 400 cm 2 , and 1160 cm 2 to achieve record efficiencies of 23.05 %, 22.32 %, and 21.1 % (certified PCE), respectively, making them the best PCE reported in the literature. Importantly, enhanced interface mechanical strength between the perovskite and PCBM layer results in significantly improved environmental and operational stability of the cells. The cells modified with Y7-BO maintained 94.4 % of the initial efficiency after 1522 hours of maximum power point aging.}, archive = {J_ANGEW}, author = {Qiuju Liu and Lei Ding and Jianfei Fu and Bolin Zheng and Dongsheng Yu and Hua Bai and Qingyong Tian and Bin Fan and Yanfeng Liu and Shuping Pang and Yang Liu}, doi = {10.1002/anie.202416390}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416390}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing the efficiency and stability of inverted perovskite solar cells and modules through top interface modification with N-type semiconductors}, volume = {64}, year = {2025}, }
• (2025). Tandem methanolysis and catalytic transfer hydrogenolysis of polyethylene terephthalate to p-xylene over Cu/ZnZrOx catalysts. ANGEW, 64(4), e202416384. (www)

  @article{ , abstract = {We demonstrate a novel approach of utilizing methanol (CH 3 OH) in a dual role for (1) the methanolysis of polyethylene terephthalate (PET) to form dimethyl terephthalate (DMT) at near-quantitative yields (~97 %) and (2) serving as an in situ H 2 source for the catalytic transfer hydrogenolysis (CTH) of DMT to p-xylene (PX, ~63 % at 240 °C and 16 h) on a reducible ZnZrO x supported Cu catalyst (i.e., Cu/ZnZrO x ). Pre- and post-reaction surface and bulk characterization, along with density functional theory (DFT) computations, explicate the dual role of the metal-support interface of Cu/ZnZrO x in activating both CH 3 OH and DMT and facilitating a lower free-energy pathway for both CH 3 OH dehydrogenation and DMT hydrogenolysis, compared to Cu supported on a redox-neutral SiO 2 support. Loading studies and thermodynamic calculations showed that, under reaction conditions, CH 3 OH in the gas phase, rather than in the liquid phase, is critical for CTH of DMT. Interestingly, the Cu/ZnZrO x catalyst was also effective for the methanolysis and hydrogenolysis of C−C bonds (compared to C−O bonds for PET) of waste polycarbonate (PC), largely forming xylenol (~38 %) and methyl isopropyl anisole (~42 %) demonstrating the versatility of this approach toward valorizing a wide range of condensation polymers.}, archive = {J_ANGEW}, author = {Ryan Helmer and Siddhesh S. Borkar and Aojie Li and Fatima Mahnaz and Jenna Vito and Michelle Bishop and Ashfaq Iftakher and M. M. Faruque Hasan and Srinivas Rangarajan and Manish Shetty}, doi = {10.1002/anie.202416384}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416384}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tandem methanolysis and catalytic transfer hydrogenolysis of polyethylene terephthalate to p-xylene over Cu/ZnZrOx catalysts}, volume = {64}, year = {2025}, }
• (2025). Near-unity photothermal CO2 hydrogenation to methanol based on a Molecule/Nanocarbon hybrid catalyst. ANGEW, 64(4), e202416376. (www)

  @article{ , abstract = {Solar-driven CO 2 -to-methanol conversion provides an intriguing route for both solar energy storage and CO 2 mitigation. For scalable applications, near-unity methanol selectivity is highly desirable to reduce the energy and cost endowed by low-value byproducts and complex separation processes, but so far has not been achieved. Here we demonstrate a molecule/nanocarbon hybrid catalyst composed of carbon nanotube-supported molecularly dispersed cobalt phthalocyanine (CoPc/CNT), which synergistically integrates high photothermal conversion capability for affording an optimal reaction temperature with homogeneous and intrinsically-efficient active sites, to achieve a catalytic activity of 2.4 mmol g cat −1 h −1 and selectivity of ~99 % in direct photothermal CO 2 hydrogenation to methanol reaction. Both theoretical calculations and operando characterizations consistently confirm that the unique electronic structure of CoPc and appropriate reaction temperature cooperatively enable a thermodynamic favorable reaction pathway for highly selective methanol production. This work represents an important milestone towards the development of advanced photothermal catalysts for scalable and cost-effective CO 2 hydrogenation.}, archive = {J_ANGEW}, author = {Siyun Ren and Junnan Han and Zhengwei Yang and Jie Liang and Shijia Feng and Xing Zhang and Jun Xu and Jia Zhu}, doi = {10.1002/anie.202416376}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416376}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-unity photothermal CO2 hydrogenation to methanol based on a Molecule/Nanocarbon hybrid catalyst}, volume = {64}, year = {2025}, }
• (2025). Controlling the polarity of Metal–Organic frameworks to promote electrochemical CO2 reduction. ANGEW, 64(4), e202416367. (www)

  @article{ , abstract = {The addition of polar functional groups to porous structures is an effective strategy for increasing the ability of metal–organic frameworks (MOFs) to capture CO 2 by enhancing interactions between the dipoles of the polar functional groups and the quadrupoles of CO 2 . However, the potential of MOFs with polar functional groups to activate CO 2 has not been investigated in the context of CO 2 electrolysis. In this study, we report a mixed-ligand strategy to incorporate various functional groups in the MOFs. We found that substituents with strong polarity led to increased catalytic performance of electrochemical CO 2 reduction for these polarized MOFs. Both experimental and theoretical evidence indicates that the presence of polar functional groups induces a charge redistribution in the micropores of MOFs. We have shown that higher electron densities of sp 2 -carbon atoms in benzimidazolate ligands reduces the energy barrier to generate *COOH, which is simultaneously controlled by the mass transfer of CO 2 . Our research offers an effective method of disrupting local electron neutrality in the pores of electrocatalysts/supports to activate CO 2 under electrochemical conditions.}, archive = {J_ANGEW}, author = {Junnan Chen and Guangming Wang and Yingjun Dong and Jiapeng Ji and Linbo Li and Ming Xue and Xiaolong Zhang and Hui-Ming Cheng}, doi = {10.1002/anie.202416367}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416367}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlling the polarity of Metal–Organic frameworks to promote electrochemical CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Kinetic control over social and narcissistic self-sorting from multicomponent mixtures in seed-initiated supramolecular polymerization by fine-tuning of steric effects. ANGEW, 64(4), e202416361. (www)

  @article{ , abstract = {Supramolecular polymers offer an intriguing possibility to transfer molecular properties from the nano- to the mesoscale. Towards this achievement, seed-initiated supramolecular polymerization has emerged as a powerful tool, as it prevents unlimited growth and enables size control of the assembly outcome. However, the potential application of the seeding method in the context of complex supramolecular systems is hitherto unclear. Herein we demonstrate that minute differences in molecular design in direct proximity to intermolecular recognition sites govern the molecular packing and in turn dictate the efficacy of seeded polymerization processes. We introduce a stepwise increase in steric demand in the central amino acid residue of a diamide system, which gradually increases the rotational displacement within the aggregated state. This fine-tuning of the molecular packing directly affects the propensity of the different aggregates to act as seeds for the other supramolecular synthons. In turn this allows us to selectively target specific trapped monomer states in binary mixtures for social or narcissistic seeded polymerization.}, archive = {J_ANGEW}, author = {Kentaro Matsumoto and Nils Bäumer and Soichiro Ogi and Shigehiro Yamaguchi}, doi = {10.1002/anie.202416361}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416361}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Kinetic control over social and narcissistic self-sorting from multicomponent mixtures in seed-initiated supramolecular polymerization by fine-tuning of steric effects}, volume = {64}, year = {2025}, }
• (2025). Unprecedented photocatalytic hydrogen peroxide production via covalent triazine frameworks constructed from fused building blocks. ANGEW, 64(4), e202416350. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have garnered attention for their potential in photocatalytic hydrogen peroxide (H 2 O 2 ) production. However, their photocatalytic efficiency is impeded by insufficient exciton dissociation and charge carrier transport. Constructing COFs with superior planarity is an effective way to enhance the π-conjugation degree and facilitate electron-hole separation. Nonetheless, the conventional linear linkers of COFs inevitably introduce torsional strain that disrupts coplanarity. Herein, we address this issue by introducing inherently coplanar triazine rings as linkers and fused building blocks as monomers to create covalent triazine frameworks (CTFs) with superior coplanarity. Both experimental and theoretical calculations confirm that CTFs constructed from fused building blocks significantly enhance the electron-hole separation efficiency and improve the photocatalytic performance, compared to the CTFs constructed with non-fused building blocks. The frontier molecular orbitals and electrostatic potentials (ESP) revealed that the oxygen reduction reaction (ORR) is preferentially facilitated by the triazine rings, with the water oxidation reaction (WOR) likely occurring at the thiophene-containing moiety. Remarkably, CTF-BTT achieved an exceptional H 2 O 2 production rate of 74956 μmol g −1 h −1 when employing 10 % benzyl alcohol (V/V) as a sacrificial agent in an O 2 -saturated atmosphere, surpassing existing photocatalysts by nearly an order of magnitude. Our findings provide valuable insights for designing highly coplanar polymer-based photocatalysts that enhance the solar-to-chemical energy conversion process.}, archive = {J_ANGEW}, author = {Ruixue Sun and Xiaoju Yang and Xunliang Hu and Yantong Guo and Yaqin Zhang and Chang Shu and Xuan Yang and Hui Gao and Xiaoyan Wang and Irshad Hussain and Bien Tan}, doi = {10.1002/anie.202416350}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unprecedented photocatalytic hydrogen peroxide production via covalent triazine frameworks constructed from fused building blocks}, volume = {64}, year = {2025}, }
• (2025). Fe−N co-doped BiVO4 photoanode with record photocurrent for water oxidation. ANGEW, 64(4), e202416340. (www)

  @article{ , abstract = {Bismuth vanadate (BVO) ranks among the most promising photoanodes for photoelectrochemical (PEC) water splitting. Nonetheless, slow charge separation and transport, besides the sluggish water oxidation kinetics, are key barriers to its photoefficiency. Here, we present a co-doping strategy that significantly improves the charge separation performance of BVO photoanodes. We found that, under standard one sun illumination, the Fe−N co-doped BVO photoanode (Fe−N−BVO) by N-coordinated Fe precursor reaches a record photocurrent density of 7.01 mA cm −2 at 1.23 V vs RHE after modified a surface co-catalyst (FeNiOOH), and exhibits an outstanding stability. By contrast, much lower photocurrent density is obtained for the N-doped, Fe-doped and Fe/N-doped BVO photoanode with separated N and Fe precursors. The detailed experimental characterizations show that the high activity of the Fe−N co-doped BVO photoanode is attributed to the enhanced photo-induced bulk charge separation, as well as the accelerated surface water oxidation kinetics. XPS, EXAFS and DFT calculations clearly show that, instead of formation of deep trapping state in the individually doped BVO, the co-doping of Fe−N into BVO generates Fe-based electronic states just below the bottom of conduction band and N-derived states just above the top of valence band. Such modulations in electronic structure enable the efficient trap of the electrons and holes to enhance the separation of photo-induced carriers, but hinder the charge recombination originated from the deep trapping sites.}, archive = {J_ANGEW}, author = {Jie Yang and Chaoyuan Deng and Yu Lei and Mengyu Duan and Yisen Yang and Xiaoran Chen and Sipeng Yang and Jikun Li and Hua Sheng and Weiqun Shi and Chuncheng Chen and Jincai Zhao}, doi = {10.1002/anie.202416340}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416340}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fe−N co-doped BiVO4 photoanode with record photocurrent for water oxidation}, volume = {64}, year = {2025}, }
• (2025). Guest-induced “Breathing-helical” dynamic system of a porphyrinic metallo-organic cage for advanced conformational manipulation. ANGEW, 64(4), e202416327. (www)

  @article{ , abstract = {Host-guest dynamic systems in coordination-driven metallo-organic cages have gained significant attentions since their promising applications in chiral separation, drug delivery, and catalytical fields. To maximize guest-binding affinity, hosts adopting multiple conformations are widely investigated on their structural flexibility for guest accommodation. In this study, a novel metallo-organic cage S with breathing inner cavity and freely twisted side chains was proposed. Single-crystal X-ray diffraction analyses depicted a characteristic “breathing-helical” dynamic system on the semiflexible framework, which led to an unprecedent co-crystallisation of racemic and symmetric conformations via the encapsulation locking of C 70 guests. By taking advantages of the high binding affinity, selective extraction of C 70 was realized. This research provides new ideas for the modification on the helicities of metallo-organic cages, which could pave a new way for advanced conformational manipulation of supramolecular host systems.}, archive = {J_ANGEW}, author = {Qiangqiang Dong and Fengxue Liu and Jun Wang and Ermeng Han and He Zhao and Bangtang Chen and Kaixiu Li and Jie Yuan and Zhilong Jiang and Mingzhao Chen and Yiming Li and Die Liu and Yifan Lin and Pingshan Wang}, doi = {10.1002/anie.202416327}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Guest-induced “Breathing-helical” dynamic system of a porphyrinic metallo-organic cage for advanced conformational manipulation}, volume = {64}, year = {2025}, }
• (2025). A helicene-based single-molecule inductor and capacitor with frequency-dependent charge-transport pathways. ANGEW, 64(4), e202416319. (www)

  @article{ , abstract = {Despite extensive studies has been explored on single-molecule switches and rectifiers, the design of single-molecule inductors has not been explored due to the experimental challenges in the investigation of frequency-dependent charge transport at the single-molecule scale. In this study, we synthesized a helicene-based helical molecular wire and carried out meticulous single-molecule conductance measurements, combined with current–voltage (IV) studies with varying frequencies using the scanning tunneling microscope break junction (STM-BJ) technique. Our results reveal the formation of a single-molecule junction and highlight the unique behavior of the molecular wire in response to different alternating current (AC) varying frequencies. The transport of charges occurs selectively either through the coiled backbone of the conjugated helical structure or vertically via π–π stacking, depending on the frequency of the applied AC. Notably, our investigation demonstrates the functionality of the wire as an inductor at low frequencies, and a capacitor at high frequencies. This work lays the foundation for a systematic approach to designing, fabricating, and implementing single-molecule logic devices such as inductors and wave filters.}, archive = {J_ANGEW}, author = {Pengxing He and Jingyao Ye and Junrui Zhang and Taige Lu and Wenying Cui and Junyang Liu and Chengshuo Shen and Wenjing Hong and Xunshan Liu}, doi = {10.1002/anie.202416319}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416319}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A helicene-based single-molecule inductor and capacitor with frequency-dependent charge-transport pathways}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed asymmetric hydrogenation of unsymmetrical ortho-br substituted benzophenones. ANGEW, 64(4), e202416313. (www)

  @article{ , abstract = {The asymmetric hydrogenation of benzophenones, catalyzed by low-activity earth-abundant metal copper, has hitherto remained a challenge due to the substrates equipped with two indistinguishably similar aryl groups. In this study, we demonstrated that the prochiral carbon of the ortho -bromine substrate exhibits the highest electrophilicity and high reactivity among the ortho -halogen substituted benzophenones, as determined by the Fukui function ( f + ) analysis and hydrogenation reaction. Considering that the enantiodirecting functional bromine group can be easily derivatized and removed in the products, we successfully achieved a green copper-catalyzed asymmetric hydrogenation of ortho -bromine substituted benzophenones. This method yielded a series of chiral benzhydrols with excellent results. The utility of this protocol has been validated through a gram-scale reaction and subsequent product transformations. Independent gradient model based on Hirshfeld partition (IGMH) and energy decomposition analysis (EDA) indicate that the CH⋅⋅⋅HC multiple attractive dispersion interactions (MADI) effect between the catalyst and substrate enhances the catalyst's activity.}, archive = {J_ANGEW}, author = {Jing Guan and Yicong Luo and Qiyuan Wang and Jianzhong Chen and Wanbin Zhang}, doi = {10.1002/anie.202416313}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416313}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed asymmetric hydrogenation of unsymmetrical ortho-br substituted benzophenones}, volume = {64}, year = {2025}, }
• (2025). Unleashed remarkable energy storage performance in Bi0.5K0.5TiO3-based relaxor ferroelectrics by local structural fluctuation. ANGEW, 64(4), e202416291. (www)

  @article{ , abstract = {Dielectric capacitors harvest energy through an electrostatic storage process, which enables an ultrafast charging-discharging rate and ultrahigh power density. However, achieving high energy density ( W rec ) and efficiency ( η ) simultaneously, especially when preserving them across a wide frequency/temperature range or cycling numbers, remains challenging. In this work, by especially introducing NaTaO 3 into the representative ferroelectric relaxor of Bi 0.5 K 0.5 TiO 3 -Bi 0.5 Na 0.5 TiO 3 and leveraging the mismatch between B-site atoms, we proposed a method of enhancing local structural fluctuation to refine the polar configuration and to effectively improve its overall energy-storage performances. As a consequence, the ceramic exhibits an ultrahigh W rec of 15.0 J/cm 3 and high η up to 80 %, along with a very wide frequency stability of 10–200 Hz and extensive cycling number up to 10 8 . In-depth local structure and chemical environment investigations, consisting of atom-scale electron microscopy, neutron total scattering, and solid-state nuclear magnetic resonance, reveal that the randomly distributed A/B-site atom pairs emerge in the system, leading to the evident local structural fluctuations and concomitant polymorphic polar nanodomains. These key ingredients contribute to the large polarization, minimal hysteresis, and high breakdown strength, thereby promoting energy-storage performances. This work opens a new path for designing high-performance dielectric capacitors via manipulating local structural fluctuations.}, archive = {J_ANGEW}, author = {Weiwei Cao and Tianyu Li and Kai Li and Yueyun Huang and Hailong Xie and Yonghao Yao and Zheng Sun and Chenjie Lou and Wenda Zhang and Chengxin Xu and Lifeng Zhu and Bing Xie and Ji Zhang and Matthew G. Tucker and Hui Liu and Huajie Luo and Mingxue Tang and Jun Chen}, doi = {10.1002/anie.202416291}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416291}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unleashed remarkable energy storage performance in Bi0.5K0.5TiO3-based relaxor ferroelectrics by local structural fluctuation}, volume = {64}, year = {2025}, }
• (2025). Inhomogeneous coordination in high-entropy o3-type cathodes enables suppressed slab gliding and durable sodium storage. ANGEW, 64(4), e202416290. (www)

  @article{ , abstract = {O3-type layered oxides are highly promising cathodes for sodium-ion batteries (SIBs), however they undergo complex phase transitions and exhibit high sensibility to air, leading to subpar cycling performance and commercial viability. In this work, we report a layered cathode material (NaNi 0.29 Cu 0.1 Mg 0.05 Li 0.05 Mn 0.2 Ti 0.2 Sn 0.11 O 2 ) with a sate-of-the-art high-entropy compositional design. We unveil that such a configuration featuring inhomogeneous coordination environment of transition metal (TM) elements, can enable enhanced gliding energy (−0.38 vs −0.58 eV) of TMO 2 slabs upon desodiation both theoretically and experimentally, which underlies the fundamental origin of the outstanding structural stability of HEO materials. As a consequence, the complex phase transitions (O3−O′3−P3−P′3−P3′−O3′) of conventional O3-type cathode have been eliminated, and the as-obtained material demonstrates exceptional structural robustness and integrity with an ultra-long cycle life in a quasi-solid-state cell (maintaining 73.2 % capacity after 1000 cycles at 2 C). Moreover, the material presents satisfactory air stability, with minimal structural and electrochemical degradation when directly exposed to the air. An Ah-scale pouch cell based on the cathode material is constructed, demonstrating a capacity retention of 83.6 % after 500 cycles, signaling substantial promise for commercial applications.}, archive = {J_ANGEW}, author = {Shengyu Zhao and Fanghua Ning and Xuan Yu and Baiyu Guo and Reinaldo F. Teófilo and Jianyu Huang and Qinhao Shi and Shuang Wu and Wuliang Feng and Yufeng Zhao}, doi = {10.1002/anie.202416290}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416290}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inhomogeneous coordination in high-entropy o3-type cathodes enables suppressed slab gliding and durable sodium storage}, volume = {64}, year = {2025}, }
• (2025). Artificial photosynthetic cell with molecular biomimetic thylakoid. ANGEW, 64(4), e202416289. (www)

  @article{ , abstract = {The construction of solar-to-chemical conversion system by mimicking the photosynthetic network of the chloroplast holds great promise on efficient solar energy utilization. We developed an artificial photosynthetic cell (APC) based on molecular biomimetic thylakoid (CoTPP-FePy) to split water into hydrogen and oxygen (H 2 and O 2 ) at low driving voltage (1.1 V) and neutral condition (pH≈7). The CoTPP-FePy can emulate the light reaction in thylakoids to produce O 2 by coupling light harvesting, photocatalysis, and electron/energy storage (Fe III /Fe II −Py). Subsequently, a membrane electrode assembly (MEA) were employed to simulate the dark reaction, wherein the proton, electron and energy generated by the light reaction can drive the H 2 producing process. By a temporally and spatially coupling of the light and dark reactions, the resulting APC achieved a solar conversion efficiency of 3.1 %, exceeding that of natural photosynthetic systems and demonstrating the potential of artificial photosynthesis.}, archive = {J_ANGEW}, author = {Enbo Zhou and Shichen Yan and Xiang Zhang and Ateeq Ur Rehman Baloch and Yangdan Hui and Futong Wang and Lei Jiao and Jiafang Xie and Daqiang Yuan and Yaobing Wang}, doi = {10.1002/anie.202416289}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416289}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial photosynthetic cell with molecular biomimetic thylakoid}, volume = {64}, year = {2025}, }
• (2025). High performance organic mixed ionic-electronic polymeric conductor with stability to autoclave sterilization. ANGEW, 64(4), e202416288. (www)

  @article{ , abstract = {We present a series of newly developed donor-acceptor (D-A) polymers designed specifically for organic electrochemical transistors (OECTs) synthesized by a straightforward route. All polymers exhibited accumulation mode behavior in OECT devices, and tuning of the donor comonomer resulted in a three-order-of-magnitude increase in transconductance. The best polymer gFBT-g2T, exhibited normalized peak transconductance ( g m,norm ) of 298±10.4 S cm −1 with a corresponding product of charge-carrier mobility and volumetric capacitance, μC *, of 847 F V −1 cm −1 s −1 and a μ of 5.76 cm 2 V −1 s −1 , amongst the highest reported to date. Furthermore, gFBT-g2T exhibited exceptional temperature stability, maintaining the outstanding electrochemical performance even after undergoing a standard (autoclave) high pressure steam sterilization procedure. Steam treatment was also found to promote film porosity, with the formation of circular 200–400 nm voids. These results demonstrate the potential of gFBT-g2T in p-type accumulation mode OECTs, and pave the way for the use in implantable bioelectronics for medical applications.}, archive = {J_ANGEW}, author = {Hailiang Liao and Achilleas Savva and Adam V. Marsh and Yu-Ying Yang and Hendrik Faber and Martina Rimmele and Matteo Sanviti and Renqian Zhou and Abdul-Hamid Emwas and Jaime Martín and Thomas D. Anthopoulos and Martin Heeney}, doi = {10.1002/anie.202416288}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416288}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High performance organic mixed ionic-electronic polymeric conductor with stability to autoclave sterilization}, volume = {64}, year = {2025}, }
• (2025). Stabilization of high-valent molecular cobalt sites through oxidized phosphorus in reduced graphene oxide for enhanced oxygen evolution catalysis. ANGEW, 64(4), e202416274. (www)

  @article{ , abstract = {Heterogeneous molecular cobalt (Co) sites represent one type of classical catalytic sites for electrochemical oxygen evolution reaction (OER) in alkaline solutions. There are dynamic equilibriums between Co 2+ , Co 3+ and Co 4+ states coupling with OH − /H + interaction before and during the OER event. Since the emergence of Co 2+ sites is detrimental to the OER cycle, the stabilization of high-valent Co sites to shift away from the equilibrium becomes critical and is proposed as a new strategy to enhance OER. Herein, phosphorus (P) atoms were doped into reduced graphene oxide to link molecular Co 2+ acetylacetonate toward synthesizing a novel heterogeneous molecular catalyst. By increasing the oxidation states of P heteroatoms, the linked Co sites were spontaneously oxidized from 2+ to 3+ states in a KOH solution through OH − ions coupling at an open circuit condition. With excluding the Co 2+ sites, the as-derived Co sites with 3+ initial states exhibited intrinsically high OER activity, validating the effectiveness of the strategy of stabilizing high valence Co sites.}, archive = {J_ANGEW}, author = {Jiahui Yang and Guoliang Dai and Wenjuan Song and Poe Ei Phyu Win and Jiong Wang and Xin Wang}, doi = {10.1002/anie.202416274}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416274}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stabilization of high-valent molecular cobalt sites through oxidized phosphorus in reduced graphene oxide for enhanced oxygen evolution catalysis}, volume = {64}, year = {2025}, }
• (2025). Zincophilic sites enriched hydrogen-bonded organic framework as multifunctional regulating interfacial layers for stable zinc metal batteries. ANGEW, 64(4), e202416271. (www)

  @article{ , abstract = {To construct an efficient regulating layer for Zn anodes that can simultaneously address the issues of dendritic growth and side reactions is highly demanded for stable zinc metal batteries (ZMBs). Herein, we fabricate a hydrogen-bonded organic framework (HOF) enriched with zincophilic sites as a multifunctional layer to regulate Zn anodes with controlled spatial ion flux and stable interfacial chemistry (MA-BTA@Zn). The framework with abundant H-bonds helps capture H 2 O and remove the solvated shells on [Zn(H 2 O) 6 ] 2+ , leading to suppressed side reactions. The HOF layer also helps form electrolyte-philic surfaces and expose Zn (002) crystal planes which benefit for rapid conduction and uniform deposition of Zn 2+ , and weakened sides reactions. Additionally, the electrochemically active zincophilic sites (C=O, −NH 2 and triazine groups) favor the targeted guidance and penetration of Zn 2+ and provide advantageous sites for uniform Zn deposition. High Young's modulus of the HOF layer further contributes to a high interfacial flexibility and stability against Zn plating-associated stress. The MA-BTA@Zn symmetric cells thereby obtain a substantially extended battery life over 1000 h at 4 mA cm −2 . The MA-BTA@Zn||Cu half-cell demonstrates a highly reversible Zn stripping/plating process over 1500 cycles with impressive average Coulombic efficiency (CE) of 99.5 % at 10 mA cm −2 .}, archive = {J_ANGEW}, author = {Jie Ding and Jiajing He and Ling Chen and Yi Sun and Yi Xu and Li-Ping Lv and Yong Wang}, doi = {10.1002/anie.202416271}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416271}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Zincophilic sites enriched hydrogen-bonded organic framework as multifunctional regulating interfacial layers for stable zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). I3−-mediated oxygen evolution activities to boost rechargeable zinc-air battery performance with low charging voltage and long cycling life. ANGEW, 64(4), e202416235. (www)

  @article{ , abstract = {An effective strategy to facilitate oxygen redox chemistry in metal-air batteries is to introduce a redox mediator into the liquid electrolyte. The rational utilization of redox mediators to accelerate the charging kinetics while ensuring the long lifetime of alkaline Zn-air batteries is challenging. Here, we apply commercial acetylene black catalysts to achieve an I 3 − -mediated Zn-air battery by using ZnI 2 additives that provide I 3 − to accelerate the cathodic redox chemistry and regulate the uniform deposition of Zn 2+ on the anode. The Zn-air battery performs an ultra-long cycle life of over 600 h at 5 mA cm −2 with a final charge voltage of 1.87 V. We demonstrate that I − mainly generates I 3 − on the surface of carbon catalysts during the electrochemically charging process, which can further chemically react with OH − to generate oxygen and further revert to I − , thus obtaining a stable electrochemical system. This work offers a strategy to simultaneously improve the cycling life and reduce the charging voltage of Zn-air batteries through redox mediator methods.}, archive = {J_ANGEW}, author = {Xiaohong Zou and Qian Lu and Lizhen Wu and Kouer Zhang and Mingcong Tang and Haijiao Xie and Xiao Zhang and Zongping Shao and Liang An}, doi = {10.1002/anie.202416235}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416235}, shortjournal = {Angew. Chem. Int. Edit.}, title = {I3−-mediated oxygen evolution activities to boost rechargeable zinc-air battery performance with low charging voltage and long cycling life}, volume = {64}, year = {2025}, }
• (2025). Chiral polar bifunctional polyimide enantiomers for asymmetric photo- and piezo-catalysis. ANGEW, 64(4), e202416221. (www)

  @article{ , abstract = {Chiral catalysts for asymmetric catalysis represent a crucial research focus in chemistry and materials science. However, a few cases about chiral-dependent photocatalysts primarily focus on plasmonic noble metals. Particularly, developing chiral nano-catalysts that can be driven by mechanical energy remains in the blank stage. Herein, organic polymer-based enantiomers, chiral polar polyimide (PI) microspheric nano-assembly are synthesized as novel bifunctional catalysts for asymmetric photocatalysis and piezocatalysis. The PI catalyst enantiomers present enantioselectivity towards left- and right-circularly polarized light, demonstrating chiral-dependent H 2 O 2 photoproduction. Interestingly, enantioselectivity of the catalyst reverses under irradiation of different bands, presenting tunability in the interaction between chiral catalysts and circularly polarized light. For the first time, enantioselective piezocatalytic behavior is demonstrated by the chiral polar PI catalysts. They show remarkable chiral preference for asymmetric Diels–Alder reaction and enantioselective conversion of tyrosine substrates under ultrasonic vibration. The findings provide a new perspective into exploring metal-free chiral catalysts and their asymmetric catalysis applications across multiple energy forms.}, archive = {J_ANGEW}, author = {Yan Zhang and Yemeng Sun and Xi Ren and Jun Hu and Hongjian Yu and Jingang Liu and Hongwei Huang and Jie Han}, doi = {10.1002/anie.202416221}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral polar bifunctional polyimide enantiomers for asymmetric photo- and piezo-catalysis}, volume = {64}, year = {2025}, }
• (2025). Structure-agnostic bioactivity-driven combinatorial biosynthesis reveals new antidiabetic and anticancer triterpenoids. ANGEW, 64(4), e202416218. (www)

  @article{ , abstract = {Although combinatorial biosynthesis can dramatically expand the chemical structures of bioactive natural products to identify molecules with improved characteristics, progress in this direction has been hampered by the difficulty in isolating and characterizing the numerous produced compounds. This challenge could be overcome with improved designs that enable the analysis of the bioactivity of the produced metabolites ahead of the time-consuming isolation procedures. Herein, we showcase a structure-agnostic bioactivity-driven combinatorial biosynthesis workflow that introduces bioactivity assessment as a selection-driving force to guide iterative combinatorial biosynthesis rounds towards enzyme combinations with increasing bioactivity. We apply this approach to produce triterpenoids with potent bioactivity against PTP1B, a promising molecular target for diabetes and cancer treatment. We demonstrate that the bioactivity-guided workflow can expedite the combinatorial process by enabling the narrowing down of more than 1000 possible combinations to only five highly potent candidates. By focusing the isolation and structural elucidation effort on only these five strains, we reveal 20 structurally diverse triterpenoids, including four new compounds and a novel triterpenoid-anthranilic acid hybrid, as potent PTP1B inhibitors. This workflow expedites hit identification by combinatorial biosynthesis and is applicable to many other types of bioactive natural products, therefore providing a strategy for accelerated drug discovery.}, archive = {J_ANGEW}, author = {Yong Zhao and Yao-Tao Duan and Jie Zang and Morten H. Raadam and Irini Pateraki and Karel Miettinen and Dan Staerk and Sotirios C. Kampranis}, doi = {10.1002/anie.202416218}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416218}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structure-agnostic bioactivity-driven combinatorial biosynthesis reveals new antidiabetic and anticancer triterpenoids}, volume = {64}, year = {2025}, }
• (2025). Boron enabled directed [2+2]- and dearomative [4+2]-cycloadditions initiated by energy transfer. ANGEW, 64(4), e202416215. (www)

  @article{ , abstract = {A strategy for the photosensitized [2+2]-cycloaddition between styrenyl dihaloboranes and unactivated allylamines to access cyclobutylboronates with control of stereochemistry and regiochemistry is presented. The success of the reaction relies on the temporary coordination between in situ generated dihaloboranes and amines under mild reaction conditions. In addition, cyclobutanes with varying substitution patterns have been prepared using N -heterocycles as directing group. Manipulation of the C−B bond allows for the synthesis of a diverse class of cyclobutanes from simple precursors. Moreover, these reactions lead to the synthesis of complex amines and heteroaromatic compounds, which have significant utility in medicinal chemistry. Finally, a dearomative [4+2]-cycloaddition of naphthalenes using a boron-enabled temporary tethering strategy has also been uncovered to synthesize complex 3-dimensional borylated building blocks.}, archive = {J_ANGEW}, author = {Souvik Adak and Partha Sarathi Hazra and Carter B. Fox and M. Kevin Brown}, doi = {10.1002/anie.202416215}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416215}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boron enabled directed [2+2]- and dearomative [4+2]-cycloadditions initiated by energy transfer}, volume = {64}, year = {2025}, }
• (2025). Total synthesis of berkeleyone a and preaustinoid a through epoxypolyene cyclization. ANGEW, 64(4), e202416211. (www)

  @article{ , abstract = {A bioinspired Lewis acid-catalyzed epoxypolyene cyclization was developed to construct the tetracyclic framework containing a bicyclo[3.3.1]nonane core and seven chiral centers. The usage of this approach for assembling these natural products of 6/6/6/6 tetracyclic skeleton with bicyclo[3.3.1]nonane core is demonstrated by the total synthesis of highly oxidized berkeleyone A and preaustinoid A.}, archive = {J_ANGEW}, author = {Xingyi Li and Zhifang Chang and Shengfu Duan and Zhixiang Xie}, doi = {10.1002/anie.202416211}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416211}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Total synthesis of berkeleyone a and preaustinoid a through epoxypolyene cyclization}, volume = {64}, year = {2025}, }
• (2025). Single-atom barium promoter enormously enhanced non-noble metal catalyst for ammonia decomposition. ANGEW, 64(4), e202416195. (www)

  @article{ , abstract = {As a well-established topic, single-atom catalyst has drawn growing interest for its high utilization of metal. However, researchers prefer to develop various active metals with single-atom form, the intrinsic roles of single-atom promoters are usually underrated, which are significant in boosting reaction activity. In this work, Ba single atoms were in situ prepared in the Co−Ba/Y 2 O 3 catalyst with crystallized BaCO 3 as the precursor under the ammonia decomposition reaction condition. The optimized Co−Ba/Y 2 O 3 catalyst achieves extremely high H 2 production rate of 138.3 mmolH 2 ⋅ g cat −1 ⋅ min −1 at very low temperature (500 °C, GHSV=840,000 mL ⋅ g −1 ⋅ h −1 ) and Co−Ba/Y 2 O 3 exhibits excellent durability during the 350 h test, which realizes the highest activity among all non-noble catalysts, and reaches or even exceeds numerous reported Ru-based catalysts. Both Y 2 O 3 and Co demonstrate positive interactions with Ba, which significantly facilitates the dispersion of Ba species at high temperatures (≥600 °C). Ba single atoms significantly enhance the charge density of Co and form additionally active Co−O−Ba−Y 2 O 3 interfacial sites, which alleviates hydrogen poisoning and decreases the reaction barrier of the N−H bond activation of *NH. The exploration of atomically dispersed promoters is groundbreaking in heterogeneous catalysis, which opens up a whole new domain of catalytic material.}, archive = {J_ANGEW}, author = {Kai Xu and Yuan-Yi Zhang and Wei-Wei Wang and Mi Peng and Jin-Cheng Liu and Chao Ma and Ya-Wen Zhang and Chun-Jiang Jia and Ding Ma and Chun-Hua Yan}, doi = {10.1002/anie.202416195}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416195}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-atom barium promoter enormously enhanced non-noble metal catalyst for ammonia decomposition}, volume = {64}, year = {2025}, }
• (2025). Programmable persistent room temperature phosphorescence switches through wavelength-selective photoactivation. ANGEW, 64(4), e202416189. (www)

  @article{ , abstract = {Controlling multicolor persistent room-temperature phosphorescence (RTP) through photoirradiation holds fundamental significance but remains a significant challenge. In this study, we engineered a wavelength-selective photoresponsive system utilizing the Förster resonance energy transfer strategy. This system integrates a photoactivated long-lived luminescent material as the energy donor with a fluorescent photoswitch as the energy acceptor, facilitating programmable persistent luminescence switches. Distinct afterglow color states, such as initial nonemissive, green, yellow, and orange, were achieved through irradiation at 400 nm, 365 nm, and 254 nm, respectively. Based on this capability, we established an interacting network for multistate afterglow color switching among these four emissive states. In addition, we demonstrate the potential of this wavelength-selective photoresponsive system in the photo-controlled rewritable printing of multicolor afterglow images on a single thin film. This work represents a substantial step towards the fabrication of sophisticated wavelength-selective photoresponsive systems, potentially revolutionizing applications in optical data storage, security labeling, and smart displays by enabling precise control over photoresponsive behaviors under various photoirradiation wavelengths.}, archive = {J_ANGEW}, author = {Yuchang Wang and Aiwen Shao and Jiangang Li and Juan Wei and Kuanjian Wei and Shujuan Liu and Yun Ma and Qiang Zhao}, doi = {10.1002/anie.202416189}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416189}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programmable persistent room temperature phosphorescence switches through wavelength-selective photoactivation}, volume = {64}, year = {2025}, }
• (2025). Asymmetric modification of carbazole based self-assembled monolayers by hybrid strategy for inverted perovskite solar cells. ANGEW, 64(4), e202416188. (www)

  @article{ , abstract = {Carbazole-based self-assembled molecules (SAMs) are widely applied in inverted perovskite solar cells (iPSCs) due to their unique molecular properties. However, the symmetrical structure of the carbazole-based SAMs makes it difficult to finely regulate their performance, which impedes the further enhancement of the efficiency and stability of iPSCs. This work demonstrates that by constructing an asymmetric carbazole core, 9H-thieno[2′,3′ : 4,5]thieno[3,2-b]indole) (TTID), the key properties of SAM molecules can be effectively regulated. It has been confirmed that the hybrid thieno[2,3-b]thiophene unit of this asymmetric core governs the energy level, the surface wettability, and the defect passivation capability of the SAMs, while the substituent of core has a greater impact on the molecular dipole and device stability. The synergistic effects from thieno[2,3-b]thiophene and fluorine lead to the KF-derived iPSC demonstrating a certified power conversion efficiency (PCE) of 25.17 % and excellent operational stability. This hybrid design concept offers a promising approach for the further structural modification of SAMs in iPSCs.}, archive = {J_ANGEW}, author = {Youle Huang and Mingquan Tao and Yijing Zhang and Zhihui Wang and Zhe Sun and Wenfeng Zhang and Yonglian Xiong and Xueping Zong and Yang Wang and Mao Liang}, doi = {10.1002/anie.202416188}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416188}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric modification of carbazole based self-assembled monolayers by hybrid strategy for inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Manipulating aggregate electrochemistry for high-performance organic redox flow batteries. ANGEW, 64(4), e202416184. (www)

  @article{ , abstract = {Organic molecule in solutions is the energy storage unit in the organic redox flow batteries (ORFBs), of which the aggregation is acknowledged pivotal but has been rarely investigated. By establishing a pyridinium library, the manipulation over the aggregation in solutions is investigated at the molecular level. Both theoretical calculations and physiochemical methods are used to characterize the aggregate's structure, and salient findings are as follows. First, the singly-reduced monoradicals simultaneously aggregate in a concentrated solution, which is driven by the solvation effect, orbital overlap and dispersion interaction. Second, the aggregation can be manipulated by the molecular engineering strategy and counteracted by introducing either electrostatic repulsive force or twisted geometry. Third, the monoradical's aggregation yields a decrease in the molecular singly occupied molecular orbital energy level and a linear scaling relationship with its thermodynamic potential. As a result, the increase in the concentration lowers the battery's voltage, which counteracts its effort to increase the battery's energy density. The anti-aggregation is proven effective in breaking the scaling relationship and accordingly, a molecular strategy to manipulate aggregate electrochemistry is developed. This work provides physical insights into the electrolytic solution and chemical strategy for optimizing the flow battery.}, archive = {J_ANGEW}, author = {Zhipeng Xiang and Tianlu Ren and Mingbao Huang and Wenjin Li and Liwen Wang and Kai Wan and Zhiyong Fu and Zhenxing Liang}, doi = {10.1002/anie.202416184}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416184}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manipulating aggregate electrochemistry for high-performance organic redox flow batteries}, volume = {64}, year = {2025}, }
• (2025). Metal-phthalocyanine-based two-dimensional conjugated metal-organic frameworks for electrochemical glycerol oxidation reaction. ANGEW, 64(4), e202416178. (www)

  @article{ , abstract = {Electrochemical glycerol oxidation reaction (GOR) is a promising candidate to couple with cathodic reaction, like hydrogen evolution reaction, to produce high-value product with less energy consumption. Two dimensional conjugated metal–organic frameworks (2D c -MOFs), comprising square-planar metal-coordination motifs (e.g., MO 4 , M(NH) 4 , MS 4 ), are notable for their programable active sites, intrinsic charge transport, and excellent stability, making them promising catalyst candidates for GOR. In this study, we introduce a novel class of 2D c -MOFs electrocatalysts, M 2 [NiPcS 8 ] (M=Co/Ni/Cu), which are synthesized via coordination of octathiolphthalocyaninato nickel (NiPc(SH) 8 ) with various metal centers. Due to a fast kinetic and high activity of CoS 4 sites for GOR, the electrocatalytic tests demonstrate that Co 2 [NiPcS 8 ] supported on carbon paper displays a low GOR potential of 1.35 V vs. RHE at 10 mA cm −2 , significantly reducing the overall water-electrolysis-voltage reduction by 0.27 V from oxygen evolution reaction to GOR, thereby outperforming Ni 2 [NiPcS 8 ] and Cu 2 [NiPcS 8 ]. Additionally, we have determined that the GOR activity of CoX 4 linkage sites varies with different heteroatoms, following an experimentally and theoretically confirmed activity order of CoS 4 >CoO 4 >Co(NH) 4 . The GOR performance of Co 2 [NiPcS 8 ] not only demonstrate superior performance among non-noble metal complex, but also provides critical insights on designing high-performance MOF electrocatalysts upon optimizing the electronic environment of active sites.}, archive = {J_ANGEW}, author = {Xing Huang and Mingchao Wang and Haixia Zhong and Xiaodong Li and Huaping Wang and Yang Lu and Geping Zhang and Yannan Liu and Panpan Zhang and Ruqiang Zou and Xinliang Feng and Renhao Dong}, doi = {10.1002/anie.202416178}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416178}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-phthalocyanine-based two-dimensional conjugated metal-organic frameworks for electrochemical glycerol oxidation reaction}, volume = {64}, year = {2025}, }
• (2025). High spin-state modulation of catalytic centers by weak ligand field for promoting sulfur redox reaction in lithium-sulfur batteries. ANGEW, 64(4), e202416176. (www)

  @article{ , abstract = {The spin state of transition-metal compounds in lithium-sulfur batteries (LSBs) significantly impacts the electronic properties and the kinetics of sulfur redox reactions (SRR). However, accurately designing the spin state remains challenging, which is crucial for understanding the structure-performance relationship and developing high-performance electrocatalysts. Herein, the CoF 2 , specifically the Co 2+ with 3 d 7 electrons in a high-spin state distribution (t 2g 5 e g 2 ), were tailored predictably for the first time through the weak coordination field effect of the F element. Both DFT calculations and experimental results confirm that the spin state of Co 2+ transitions from low- to high-spin configurations and strongly interacts with sulfur species through Co−S and Li−F bonds during the SRR process. This interaction weakens the S−S bond, promoting its facile cleavage from both ends while also facilitating the rapid and uniform nucleation of Li 2 S 2 /Li 2 S, thus resulting in LSBs with a capacity of 447.7 mAh g −1 at 10 C rates and stable cycling for 1000 cycles, with an acceptable practical capacity of 585 mAh g −1 at a high sulfur loading mass of 10 mg cm −2 . This work achieves rational control of the active Co 2+ d electron state through the field effect and enriches the application of spin control to accelerate SRR in LSBs.}, archive = {J_ANGEW}, author = {Qing Li and Zhipeng Ma and Ming Liu and Yajie Jiang and Minhao Fu and Yuqian Fan and Xiujuan Qin and Ailing Song and Guangjie Shao and Yuxi Xu}, doi = {10.1002/anie.202416176}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416176}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High spin-state modulation of catalytic centers by weak ligand field for promoting sulfur redox reaction in lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Design of quasi-Metal–Organic frameworks for solid polymer electrolytes enabling an ultra-stable interface with li metal anode. ANGEW, 64(4), e202416170. (www)

  @article{ , abstract = {Solid polymer electrolytes (SPEs) are crucial in the development of lithium metal batteries. Recently, metal–organic frameworks (MOFs) with open metal sites (OMSs) have shown promise as solid fillers to improve the performance of SPEs. However, the number of OMS-containing MOFs is quite limited, comprising less than 5% of the total MOFs. When considering yield, cost, and processability, the commonly used OMS-containing MOFs are no more than 10 types, causing great limitations. Herein, we reported a simple and universal methodology that converted OMS-free MOFs to OMS-rich quasi-MOFs for developing high-performance SPEs, and explored the underlying mechanism. The “OMS-polymer” and “OMS-ion” interactions were investigated in detail to elucidate the role of quasi-MOFs on battery performance. It was found that quasi-MOFs, functioning as ion sieves, can effectively regulate ion migration, thus promoting uniform Li deposition and enabling an ultra-stable interface. As a result, the Li symmetric cell stably ran over 3000 h at 0.3 mA cm −2 , while the full cell retained 85 % of its initial capacity after 1500 cycles at 1.0 C. Finally, universal testing was performed using other MOFs, confirming the generalizability and effectiveness of our design concept.}, archive = {J_ANGEW}, author = {Yifan Xu and Zhiyu Chen and Jiaqi Wang and Bai Li and Jiangnan Li and Zijian He and Lei Li and Lei Gao and Songbai Han and Juncao Bian and Jinlong Zhu and Liping Wang and Yusheng Zhao and Qiang Xu and Ruo Zhao}, doi = {10.1002/anie.202416170}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416170}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of quasi-Metal–Organic frameworks for solid polymer electrolytes enabling an ultra-stable interface with li metal anode}, volume = {64}, year = {2025}, }
• (2025). Acene-integrated buckybowls with near-infrared II absorption and over 90 % photothermal conversion efficiency. ANGEW, 64(4), e202416160. (www)

  @article{ , abstract = {Tetracene and pentacene are large, promising building blocks for construction of complex molecular nanocarbons due to their extraordinary photophysical and electronic properties. Herein, two acene-integrated buckybowls, composed of two rows of tetracenes and pentacenes fused through s -indacene unit at the zigzag edges, have been synthesized and characterized. Compared to parent tetracene and pentacene, the buckybowls are extremely stable and show much smaller electrochemical band gaps. Kinetic studies gave the bowl-to-bowl inversion barriers of 11.7 and 13.3 kcal mol −1 . Subsequent investigations on magnetic ring currents revealed two local diatropic currents at two rows of acenes and one paratropic current at the s -indacene unit, respectively. Notably, both buckybowls show a broad absorption that reaches into near-infrared II region, and a high photothermal conversion efficiency (>90 %) was achieved when exposed to near-infrared 1064 nm laser photo-irradiation. This study highlights the unusual nature of merging the intrinsic properties of acenes with the inherent properties of buckybowls and showcases a potential avenue for acene utilization for the design of novel complex nanocarbons with a broad range of applications.}, archive = {J_ANGEW}, author = {Xinyue Liu and Binjie Chen and Min Wang and Xinggui Gu and Lei Zhang}, doi = {10.1002/anie.202416160}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416160}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Acene-integrated buckybowls with near-infrared II absorption and over 90 % photothermal conversion efficiency}, volume = {64}, year = {2025}, }
• (2025). Precise regulation of the reverse intersystem crossing pathway by hybridized long-short axis strategy for high-performance multi-resonance TADF emitters. ANGEW, 64(4), e202416154. (www)

  @article{ , abstract = {Multi-resonance thermally activated delayed fluorescence (MR-TADF) molecules have experienced great success in organic light-emitting diodes (OLEDs) owing to their outstanding quantum efficiencies and narrow full width at half-maximums (FWHMs). However, the reverse intersystem crossing (RISC) rates of MR-TADF emitters are usually small, which will lead to relatively long triplet exciton lifetime and severe efficiency roll-off. Here, we report an effective molecular design strategy to introduce multichannel RISC pathways and thus increase RISC rates without compromising the color fidelity and emission efficiency by the “hybridized long-short axis (HLSA)” strategy. The TPA-CN-BN shows a near-unity photoluminescence quantum yield, rapid RISC rate of 1.4×10 5 s −1 , narrow FWHM of 23 nm, and small singlet-triplet energy gap (Δ E ST ) of 0.06 eV in solution. The non-sensitized OLED based on TPA-CN-BN exhibits a narrowband emission with the FWHM of 31 nm, in company with external quantum efficiency (EQE) of 37.9 %. Notably, the device exhibits the low efficiency roll-off as the EQEs maintain 34.8 % and 21.8 % at 100 and 1000 cd m −2 , respectively, representing the best performance for single-host OLEDs based on the BCzBN skeleton. This study provides a fresh and promising approach to realize high-performance OLEDs with high color purity and remarkable device efficiency.}, archive = {J_ANGEW}, author = {Futong Liu and Zhuang Cheng and Wei Dong and Yan Yan and Yangze Xu and Zihan Su and Yin Hu and Liang Wan and Ping Lu}, doi = {10.1002/anie.202416154}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416154}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise regulation of the reverse intersystem crossing pathway by hybridized long-short axis strategy for high-performance multi-resonance TADF emitters}, volume = {64}, year = {2025}, }
• (2025). Ultra-high metal-ion selectivity induced by intramolecular cation-π interactions for the one-pot synthesis of precise heterometallic architectures. ANGEW, 64(4), e202416150. (www)

  @article{ , abstract = {Heterometallic supramolecules, known for their unique synergistic effects, have shown broad applications in photochemistry, host-guest chemistry, and catalysis. However, there are great challenges to precisely construct heterometallic supramolecules rather than a statistical mixture, due to the limited metal-ion selectivity of coordination units. In particular, heterometallic architectures precisely encoded with different metal ions usually fail to form in a one-pot method when only one type of coordinated motif exists due to its poor metal-ion selectivity. Herein, we propose an effective intramolecular cation-π (ICπ) strategy and successfully constructed the heterometallic supramolecule Zn 2 Cu 4 L3 4 by the one-pot self-assembly of tritopic terpyridyl ligand L3 with Zn(II) and Cu(II), following a clear self-assembly mechanism in which only thermodynamic dimers ZnL1 2 and Cu 2 L2 2 were constructed with model ligands L1 , L2 , Zn(II) and Cu(II) with perfect self-sorting and an ultra-high metal-selectivity feature. The successful construction of the heterometallic supramolecule Zn 2 Cu 4 L3 4 , in which the definite sequence of metal ions Zn(II) and Cu(II) is encoded in the one-pot method, will offer a novel approach to precisely construct heterometallic architectures.}, archive = {J_ANGEW}, author = {Junjuan Shi and Kehuan Li and Hao Yu and Ningxu Han and Tianyi Yang and Xin Jiang and Xin-Qi Hao and Zhi Chen and Guanglu Wu and Houyu Zhang and Bingling Li and Ming Wang}, doi = {10.1002/anie.202416150}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416150}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-high metal-ion selectivity induced by intramolecular cation-π interactions for the one-pot synthesis of precise heterometallic architectures}, volume = {64}, year = {2025}, }
• (2025). Iron-induced localized oxide path mechanism enables efficient and stable water oxidation. ANGEW, 64(4), e202416141. (www)

  @article{ , abstract = {The sluggish reaction kinetics of the anodic oxygen evolution reaction (OER) and the inadequate catalytic performance of non-noble metal-based electrocatalysts represent substantial barriers to the development of anion exchange membrane water electrolyzer (AEMWE). This study performed the synthesis of a three-dimensional (3D) nanoflower-like electrocatalyst (CFMO) via a simple one-step method. The substitution of Co with Fe in the structure induces a localized oxide path mechanism (LOPM), facilitating direct O−O radical coupling for enhanced O 2 evolution. The optimized CFMO-2 electrocatalyst demonstrates superior OER performance, achieving an overpotential of 217 mV at 10 mA cm −2 , alongside exceptional long-term stability with minimal degradation after 1000 h of operation in 1.0 M KOH. These properties surpass most of conventional noble metal-based electrocatalysts. Furthermore, the assembled AEMWE system, utilizing CFMO-2, operates with a cell voltage of 1.65 V to deliver 1.0 A cm −2 . In situ characterizations reveal that, in addition to the traditional adsorbate evolution mechanism (AEM) at isolated Co sites, a new LOPM occurred around the Fe and Co bimetallic sites. First-principles calculations confirm the LOPM greatly reduced the energy barriers. This work highlights the potential of LOPM for improving the design of non-noble metal-based electrocatalysts and the development of AEMWE.}, archive = {J_ANGEW}, author = {Bohan Yao and Yuting Chen and Yueying Yan and Yang Yang and Huanhuan Xing and Yanchao Xu and Dongxu Jiao and Zhicai Xing and Dewen Wang and Xiurong Yang}, doi = {10.1002/anie.202416141}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iron-induced localized oxide path mechanism enables efficient and stable water oxidation}, volume = {64}, year = {2025}, }
• (2025). Harnessing the reactivity of nitroarene radical anions to create quinoline N-oxides by electrochemical reductive cyclization. ANGEW, 64(4), e202416126. (www)

  @article{ , abstract = {Electrochemical reduction of 2-allyl-substituted nitroarenes using a simple, undivided electrochemical cell with non-precious electrodes to generate nitroarene radical anions was developed. The nitroarene radical anion intermediates participate in 1,5-hydrogen atom transfer reactions to construct quinoline N -oxides bearing aryl-, heteroaryl-, alkenyl-, benzyl-, sulfonyl-, or carboxyl groups.}, archive = {J_ANGEW}, author = {Haoran Zhu and Jair N. Powell and Victoria A. Geldchen and Adam S. Drumheller and Tom G. Driver}, doi = {10.1002/anie.202416126}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416126}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing the reactivity of nitroarene radical anions to create quinoline N-oxides by electrochemical reductive cyclization}, volume = {64}, year = {2025}, }
• (2025). Ring-opening metathesis polymerization of 1,2-dihydroazete derivatives. ANGEW, 64(4), e202416124. (www)

  @article{ , abstract = {Fischer carbenes have recently found great utility in the construction of degradable metathesis materials, but investigations have been limited to oxygen-containing enol ether monomers. Here, the ring-opening metathesis polymerization of 1,2-dihydroazetes is reported. The polymerization proceeds regioselectively, and the resulting molecular weights are targetable by adjusting the Grubbs initiator loading. Under acidic conditions, the resulting polymers degrade into 3-aminopropanal derivatives through hydrolysis of the recurring enamide motifs in the polymer backbone. Additionally, the underlying kinetics and thermodynamics of the polymerization were studied through DFT calculations to elucidate the origins of metathesis regioselectivity. This work further expands the suite of monomers available to generate degradable metathesis materials and provides a flexible platform for target applications.}, archive = {J_ANGEW}, author = {Wei Xiong and Will R. Gutekunst}, doi = {10.1002/anie.202416124}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416124}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ring-opening metathesis polymerization of 1,2-dihydroazete derivatives}, volume = {64}, year = {2025}, }
• (2025). Supramolecular reconstruction of self-assembling photosensitizers for enhanced photocatalytic hydrogen evolution. ANGEW, 64(4), e202416114. (www)

  @article{ , abstract = {Natural photosynthetic systems require spatiotemporal organization to optimize photosensitized reactions and maintain overall efficiency, involving the hierarchical self-assembly of photosynthetic components and their stabilization through synergistic interactions. However, replicating this level of organization is challenging due to the difficulty in efficiently communicating supramolecular nano-assemblies with nanoparticles or biological architectures, owing to their dynamic instability. Herein, we demonstrate that the supramolecular reconstruction of self-assembled amphiphilic rhodamine B nanospheres (RN) through treatment with metal-phenolic coordination complexes results in the formation of a stable hybrid structure. This reconstructed structure enhances electron transfer efficiency, leading to improved photocatalytic performance. Due to the photoluminescence quenching property of RN and its electronic synergy with tannic acid (T) and zirconium (Z), the supramolecular complexes of hybrid nanospheres (RNT x Z y ) with Pt nanoparticles or a biological workhorse, Shewanella oneidensis MR-1, showed marked improvement in photocatalytic hydrogen production. The supramolecular hybrid particles with a metal-phenolic coordination layer showed 5.6- and 4.0-fold increases, respectively, in the productivities of hydrogen evolution catalyzed by Pt (Pt/RNT x Z y ) and MR-1 (M/RNT x Z y ), respectively. These results highlight the potential for further advancements in the structural and photochemical control of supramolecular nanomaterials for energy harvesting and bio-hybrid systems.}, archive = {J_ANGEW}, author = {Seok Hyeong Bu and Wansu Cho and Gayoung Ham and Beomjoo Yang and Jongwon Jung and Hyojung Cha and Chiyoung Park}, doi = {10.1002/anie.202416114}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416114}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular reconstruction of self-assembling photosensitizers for enhanced photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). Photoclick and release for spatiotemporally localized theranostics of single cells via in situ generation of 1,3-diaryl-1H-benzo[f]indazole-4,9-dione. ANGEW, 64(4), e202416111. (www)

  @article{ , abstract = {Bioorthogonal click-release chemistry is a cutting-edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it is challenging to achieve the precise regulation or therapy of individual cells via click-release strategies driven by proximity and thermodynamics. Herein, we propose a novel photoclick-release approach based on a photo-induced cycloaddition between 4,4′-bis( N -arylsydnone) or C -bithienyl-diarylsydnone and 2-arylamino-naphthoquinone via irradiation with 405 or 485 nm light. It constructs 1,3-diaryl-1 H -benzo[ f ]indazole-4,9-dione (BIZON) as a pharmacophore while releases an arylamine for fluorescence turn-on probing. Both photoclick reagents were tailored by connecting to the triphenyl phosphonium delivery motif for enrichment in the mitochondria of live cells. This enables an intracellular photoclick and release under the control of 405 or 485 nm light. We then discovered that the in situ photo-generated BIZON is capable of photosensitizing upon 485 or 520 nm light to produce singlet oxygen inside the mitochondria under aerobic conditions. Therefore, we realized wash-free fluorescence tracking and subsequent anti-cancer efficacy at single-cell resolution using global illumination, which provides a foundation for wavelength-gated single-cell theranostics.}, archive = {J_ANGEW}, author = {Bao-Lin Li and Sitong Li and Cefei Zhang and Yuqiao Zhou and Xiaohu Zhao and Zhipeng Yu}, doi = {10.1002/anie.202416111}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416111}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoclick and release for spatiotemporally localized theranostics of single cells via in situ generation of 1,3-diaryl-1H-benzo[f]indazole-4,9-dione}, volume = {64}, year = {2025}, }
• (2025). Cationic ring-opening polymerization-induced self-assembly (CROPISA) of 2-oxazolines: From block copolymers to one-step gradient copolymer nanoparticles. ANGEW, 64(4), e202416106. (www)

  @article{ , abstract = {In recent years, polymerization-induced self-assembly (PISA) has emerged as a powerful method for the straightforward synthesis of polymer nanoparticles at high concentration. In this study, we describe for the first time the synthesis of poly(2-oxazoline) nanoparticles by dispersion cationic ring-opening polymerization-induced self-assembly (CROPISA) in n -dodecane. Specifically, a n -dodecane-soluble aliphatic poly(2-(3-ethylheptyl)-2-oxazoline) (PEHOx) block was chain-extended with poly(2-phenyl-2-oxazoline) (PPhOx). While the PhOx monomer is soluble in n -dodecane, its polymerization leads to n -dodecane-insoluble PPhOx, which leads to in situ self-assembly of the formed PEHOx- b -PPhOx copolymers. The polymerization kinetics and micellization upon second block formation were studied, and diverse nanoparticle dispersions were prepared, featuring varying block lengths and polymer concentrations, leading to dispersions with distinctive morphologies and physical properties. Finally, we developed a single-step protocol for the synthesis of polymer nanoparticles directly from monomers via gradient copolymerization CROPISA, which exploits the significantly greater reactivity of EHOx compared to that of PhOx during the statistical copolymerization of both monomers. Notably, this approach provides access to formulations with monomer compositions otherwise unattainable through the block copolymerization method. Given the synthetic versatility and application potential of poly(2-oxazolines), the developed CROPISA method can pave the way for advanced nanomaterials with favorable properties as demonstrated by using the obtained nanoparticles for stabilization of Pickering emulsions.}, archive = {J_ANGEW}, author = {Niccolò Lusiani and Ewa Pavlova and Richard Hoogenboom and Ondrej Sedlacek}, doi = {10.1002/anie.202416106}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416106}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cationic ring-opening polymerization-induced self-assembly (CROPISA) of 2-oxazolines: From block copolymers to one-step gradient copolymer nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Bulky phosphazenium salt controlling chemoselective terpolymerization of epoxide, anhydride and CO2: From well-defined block to truly random copolymers. ANGEW, 64(4), e202416104. (www)

  @article{ , abstract = {Copolymers with precise compositions and controlled sequences are great appealing for high-performance polymeric materials, but their synthesis is very challenging. In this study, tetrakis[tris(dimethylamino)phosphoranylidenamino] phosphonium chloride (P5Cl) and triethylboron (TEB) were chosen as the binary catalyst to synthesize both well-defined block and truly random poly(ester–carbonate) copolymers via the one-pot/one-step terpolymerization of epoxide/anhydride/CO 2 under metal-free conditions. The bulky nature of phosphazenium cation not only led to loose cation–anion pairs and enhanced the reactivity, but also provided the chain-end an appropriate protection and improved the controllability. In particular, P5Cl/TEB with a molar ratio of 1/0.5 showed an extraordinary chemoselectivity for ring-opening alternating copolymerization (ROAC) of cyclohexene oxide (CHO) and phthalic anhydride (PA) first and then ROAC of CHO/CO 2 . Thus, well-defined block polyester–polycarbonate copolymers were synthesized by CHO/PA/CO 2 terpolymerization. The chemoselectivity was easily tuned and the ROAC of CHO/PA and ROAC of CHO/CO 2 occurred simultaneously with P5Cl/TEB=1/2, producing truly random poly(ester–carbonate) copolymers from CHO/PA/CO 2 . In addition, this P5Cl/TEB catalyst and the strategy to regulate its chemoselectivity are versatile for various anhydrides, epoxides and initiators. Thus, poly(ester–carbonate) copolymers with varying sequences, compositions, and topologies are successfully synthesized, making it possible to compare their properties and to expand their applications.}, archive = {J_ANGEW}, author = {Yukun Ma and Zehao Wang and Lihang Jiang and Jinbo Zhang and Chuanli Ren and Xinhui Kou and Shaofeng Liu and Zhibo Li}, doi = {10.1002/anie.202416104}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416104}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bulky phosphazenium salt controlling chemoselective terpolymerization of epoxide, anhydride and CO2: From well-defined block to truly random copolymers}, volume = {64}, year = {2025}, }
• (2025). Coupling rotary motion to helicene inversion within a molecular motor. ANGEW, 64(4), e202416097. (www)

  @article{ , abstract = {Towards complex coupled molecular motions, the remote handedness inversion of a helicene moiety was achieved by a rotary molecular motor. The use of a specifically engineered dynamic helicene stator in a novel overcrowded-alkene second-generation molecular motor based on a fluorinated dibenzofluorene fragment allows for an unprecedented control over helicity inversion. This is achieved by the mechanical coupling of the rotation of the rotor to the helicene inversion of the stator half via a remote chirality transmission process. Thus, the unidirectional rotary motion generated upon irradiation is used to invert the dynamic stereochemistry of a helicene, leading to a 6-step cycle with eight intermediates. In this cycle, both alternation between P and M configurations of the helicene stator and dynamic thermal interconversion (paddling motion) can be achieved. In-depth computational and spectroscopic studies were performed to support the associated mechanism. The control over coupled motion and dynamic helicity offers prospects for the development of complex responsive systems.}, archive = {J_ANGEW}, author = {Yohan Gisbert and Marco Ovalle and Charlotte N. Stindt and Romain Costil and Ben L. Feringa}, doi = {10.1002/anie.202416097}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416097}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coupling rotary motion to helicene inversion within a molecular motor}, volume = {64}, year = {2025}, }
• (2025). Remote enantioselective ϵ-alkylation of copper ethynylallenylidenes: Precise control of central and axial chirality. ANGEW, 64(4), e202416089. (www)

  @article{ , abstract = {Chiral tetrasubstituted allenes have emerged as important architectures for engineering biologically active compounds. The construction of unique tetrasubstituted allene scaffolds with precise control of continuous central and axial chirality remains yet to be developed. Here, we report a remote enantioselective ϵ-alkylation of yne-propargylic acetates with enals enabled by NHC and copper cooperative catalysis, leading to a series of tetrasubstituted allenes with excellent enantioselectivities (up to >99 % ee) and diastereoselectivities (up to >95 : 5 dr). This method features high regioselectivity and simultaneous control of axial and central chirality. Mechanistic studies suggest a cooperative activation mode and synergistic control of distal chirality created from the copper ethynylallenylidenes.}, archive = {J_ANGEW}, author = {Yu-Hua Wen and Minghao Liu and Yu-Hao Wang and Qian-Wei Gong and Shuai Li and Jin Song and Liu-Zhu Gong}, doi = {10.1002/anie.202416089}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416089}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Remote enantioselective ϵ-alkylation of copper ethynylallenylidenes: Precise control of central and axial chirality}, volume = {64}, year = {2025}, }
• (2025). Development of DuoMYC: A synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC. ANGEW, 64(4), e202416082. (www)

  @article{ , abstract = {The master regulator transcription factor MYC is implicated in numerous human cancers, and its targeting is a long-standing challenge in drug development. MYC is a typical ‘undruggable’ target, with no binding pockets on its DNA binding domain and extensive intrinsically disordered regions. Rather than trying to target MYC directly with classical modalities, here we engineer synthetic miniproteins that can bind to MYC's target DNA, the enhancer box (E-Box), and potently inhibit MYC-driven transcription. We crafted the miniproteins via structure-based design and a combination of solid phase peptide synthesis and site-specific crosslinking. Our lead variant, DuoMYC, binds to E-Box DNA with high affinity ( K D ~0.1 μM) and is able to enter cells and inhibit MYC-driven transcription with submicromolar potency (IC 50 =464 nM) as shown by reporter gene assay and confirmed by RNA sequencing. Notably, DuoMYC surpasses the efficacy of several other recently developed MYC inhibitors. Our results highlight the potential of engineered synthetic protein therapeutics for addressing challenging intracellular targets.}, archive = {J_ANGEW}, author = {Brecht D. Ellenbroek and Jan Pascal Kahler and Damiano Arella and Cherina Lin and Willem Jespers and Eliane Ann-Katrin Züger and Micha Drukker and Sebastian J. Pomplun}, doi = {10.1002/anie.202416082}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416082}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development of DuoMYC: A synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC}, volume = {64}, year = {2025}, }
• (2025). Solvent-controlled separation of integratively self-sorted Pd2LA2LB2 coordination cages. ANGEW, 64(4), e202416076. (www)

  @article{ , abstract = {The integrative implementation of multiple different components into metallosupramolecular self-assemblies requires sophisticated strategies to avoid the formation of statistical mixtures. Previously, the key focus was set on thermodynamically driven reactions of simple homoleptic into complex heteroleptic structures. Using Pd 2 L A 2 L B 2 -type coordination cages, we herein show that integrative self-sorting can be reversed by a change of solvent (from DMSO to MeCN) to favor narcissistic re-segregation into coexisting homoleptic species Pd 2 L A 4 and Pd 3 L B 6 . Full separation (“unsorting”) back to a mixture of the homoleptic precursors was finally achieved by selective precipitation of Pd 3 L B 6 with anionic guest G 1 from MeCN, keeping pure Pd 2 L A 4 in solution. When a mixture of homoleptic Pd 3 L B 6 and heteroleptic Pd 2 L A 2 L B 2 is exposed to a combination of two different di-anions ( G 1 and G 2 ) in DMSO, selective guest uptake gives rise to two defined coexisting host–guest complexes. A joint experimental and deep theoretical investigation via liquid-state integral equation theory of the reaction thermodynamics on a molecular level accompanied by solvent distribution analysis hints at solvent expulsion from Pd 2 L A 4 to favor the formation of Pd 2 L A 2 L B 2 in DMSO as the key entropic factor for determining the solvent-specific modulation of the cage conversion equilibrium.}, archive = {J_ANGEW}, author = {Kristina E. Ebbert and Fabian Sendzik and Laura Neukirch and Lukas Eberlein and André Platzek and Patrick Kibies and Stefan M. Kast and Guido H. Clever}, doi = {10.1002/anie.202416076}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416076}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-controlled separation of integratively self-sorted Pd2LA2LB2 coordination cages}, volume = {64}, year = {2025}, }
• (2025). Epitaxial growth of silver clusters from ag57 to ag72 via laminating multiple different anion templates. ANGEW, 64(4), e202416065. (www)

  @article{ , abstract = {The established capability of anion templates in precisely manipulating the size, geometry, and function of metal clusters is well acknowledged. However, the development of a systematic methodology for orchestrating the assembly of silver clusters, particularly those encompassing multiple distinct types of anion templates, remains elusive due to the formidable synthetic challenge. In this work, we report two novel silver clusters, Ag57 and Ag72 , using two and three different anion templates, respectively. Ag57 features a gyroscope-like monovalent cation with an Ag 3 triangle core sandwiched by one [SiW 9 O 34 ] 10− and a triad of Cl − anion templates. By intentionally introducing the third anion template, SO 4 2− , the structure is expanded to the unprecedented Ag72 (with 15 silver atoms epitaxially grown on top of Ag57 ) resembling a tumbler, inside of which two Ag 3 layers are laminated by one [SiW 9 O 34 ] 10− , seven Cl − and one SO 4 2− anion templates in parallel with respect to longitudinal orientation. It is noteworthy that Ag72 exhibits remarkable structural complexity and represents a pioneering achievement as the first silver cluster incorporating three distinct types of anion templates. In addition, Ag72 demonstrates a significant advantage over Ag57 , particular in terms of applications such as luminescent thermometers and remote laser ignition. This work not only broadens the horizon for precise control of the silver cluster structures through the integration of multiple types of hetero-anions but also lays a solid foundation for potential optical applications in the future.}, archive = {J_ANGEW}, author = {Kai Sheng and Bao-Liang Han and Zhi Wang and Zhi-Yong Gao and Chen-Ho Tung and Di Sun}, doi = {10.1002/anie.202416065}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416065}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Epitaxial growth of silver clusters from ag57 to ag72 via laminating multiple different anion templates}, volume = {64}, year = {2025}, }
• (2025). Lantern-shaped structure induced by racemic ligands in red-light-emitting metal halide with near 100 % quantum yield and multiple-stimulus response. ANGEW, 64(4), e202416062. (www)

  @article{ , abstract = {Organic-inorganic metal halides (OIMHs) have become a research hotspot in recent years due to their excellent luminescent properties and tunable emission wavelengths. However, the development of efficient red-light-emitting OIMHs remains a significant challenge. This work reports three Mn-based OIMHs derived from 1-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide: racemic one ( Rac -TBM) and chiral ones ( R -TBM and S -TBM). As a result of the synergism of chiral organic ligands inducing a unique lantern-shaped hybrid structure containing both tetrahedra and octahedra, Rac -TBM exhibits red-light emission with near-unity luminescence quantum yield. In comparison, the chiral counterparts R/S -TBM display strong green emission and circularly polarized luminescence (CPL) with a g lum value up to ±2.5×10 −2 . Interestingly, a mixture of R - and S -TBM can transform into Rac -TBM, successfully achieving a sensitive and reversible switch between red light of octahedra and green light of tetrahedra under external stimuli. The outstanding luminescent properties allow Rac -TBM to be utilized not only for X-ray radioluminescence with a detection limit down to 46.29 nGys −1 , but also for advanced information encryption systems to achieve leak-proof decryption.}, archive = {J_ANGEW}, author = {Yuechuan Wu and Shuaiqi Wang and Zhibin Lin and Liwen Kang and Junyan Wu and Qiushui Chen and Zhenghuan Lin}, doi = {10.1002/anie.202416062}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416062}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lantern-shaped structure induced by racemic ligands in red-light-emitting metal halide with near 100 % quantum yield and multiple-stimulus response}, volume = {64}, year = {2025}, }
• (2025). Room-temperature formate ester transfer hydrogenation enables an Electrochemical/Thermal organometallic cascade for methanol synthesis from CO2. ANGEW, 64(4), e202416061. (www)

  @article{ , abstract = {The reduction of CO 2 to synthetic fuels is a valuable strategy for energy storage. However, the formation of energy-dense liquid fuels such as methanol remains rare, particularly under low-temperature and low-pressure conditions that can be coupled to renewable electricity sources via electrochemistry. Here, a multicatalyst system pairing an electrocatalyst with a thermal organometallic catalyst is introduced, which enables the reduction of CO 2 to methanol at ambient temperature and pressure. The cascade methanol synthesis proceeds via CO 2 reduction to formate by electrocatalyst [Cp*Ir(bpy)Cl] + (Cp*=pentamethylcyclopentadienyl, bpy=2,2′-bipyridine), Fischer esterification of formate to isopropyl formate catalyzed by trifluoromethanesulfonic acid (HOTf), and thermal transfer hydrogenation of isopropyl formate to methanol facilitated by the organometallic catalyst (H-PNP)Ir(H) 3 (H-PNP=HN(C 2 H 4 P i Pr 2 ) 2 ). The isopropanol solvent plays several crucial roles: activating formate ion as isopropyl formate, donating hydrogen for the reduction of formate ester to methanol via transfer hydrogenation, and lowering the barrier for transfer hydrogenation through hydrogen bonding interactions. In addition to reporting a method for room-temperature reduction of challenging ester substrates, this work provides a prototype for pairing electrochemical and thermal organometallic reactions that will guide the design and development of multicatalyst cascades.}, archive = {J_ANGEW}, author = {Sergio Fernández and Eric A. Assaf and Shahbaz Ahmad and Benjamin D. Travis and Julia B. Curley and Nilay Hazari and Mehmed Z. Ertem and Alexander J. M. Miller}, doi = {10.1002/anie.202416061}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416061}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Room-temperature formate ester transfer hydrogenation enables an Electrochemical/Thermal organometallic cascade for methanol synthesis from CO2}, volume = {64}, year = {2025}, }
• (2025). Planar pentacoordinate halogens. ANGEW, 64(4), e202416057. (www)

  @article{ , abstract = {Planar hypercoordinate motifs represent an intriguing frontier in chemistry, challenging traditional bonding norms. As electronegativity of the central atom increases, achieving planar hypercoordination becomes more difficult due to restricted delocalization, making the design of planar hypercoordinate halogens particularly puzzling. Here, we conduct an extensive computational survey of Li n X n+1 − ( n =4, 5, 6; X=F, Cl, Br, I) clusters, revealing a starlike D 5 h -symmetry global minimum in Li 5 X 6 − (X=F, Cl, Br) with a planar pentacoordinate halogen (ppX), where X − is located at the center of Li 5 X 5 crown. The clusters are stabilized predominantly through electrostatic interactions between X − and Li 5 X 5 , complemented by weak covalent bonding from dative interaction. Due to the weak orbital overlap, ppX clusters exhibit localized diatropic ring currents around X and Li.}, archive = {J_ANGEW}, author = {Li-juan Cui and Lin-hong Miao and Mesías Orozco-Ic and Lu Li and Sudip Pan and Gabriel Merino and Zhong-hua Cui}, doi = {10.1002/anie.202416057}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416057}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Planar pentacoordinate halogens}, volume = {64}, year = {2025}, }
• (2025). Supramolecular interfacial assembly: Integrating supramolecular hosts into polymeric membranes through an aqueous interface. ANGEW, 64(4), e202416050. (www)

  @article{ , abstract = {Efficient incorporation of macrocycles in polymeric membranes can impart the overall matrix with new properties for a range of cutting-edge applications. Here, we introduce a Supramolecular Interfacial Assembly (SIA) method for the fabrication of polymeric membranes featuring embedded macrocycles. Through harnessing the quasi-liquid nature of the concentrated polymer solution, SIA orchestrates the homogeneous spreading of macrocycles in an aqueous layer on its surface, leading to the creation of an interface between “water/water” phases, subsequently forming a cross-linked membrane driven by supramolecular electrostatic interactions. Remarkably, compared to the traditional interfacial polymerization, SIA adheres to a “green” paradigm without the need for organic solvents. The resultant composite membrane exhibits superior performance in organic solvent nanofiltration (OSN), owing to the precise molecular sieving property provided by the macrocycles with well-defined permanent cavities. This fabrication method holds great promise for the innovative design and production of composite membranes that seamlessly integrates macrocycles with conventional polymers, which can greatly impact the design and preparation of advanced membrane materials in the future.}, archive = {J_ANGEW}, author = {Fang Fang and Peiren Liu and Weibin Lin and Lukman O. Alimi and Basem Moosa and Elizaveta Maltseva and Niveen M. Khashab}, doi = {10.1002/anie.202416050}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416050}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular interfacial assembly: Integrating supramolecular hosts into polymeric membranes through an aqueous interface}, volume = {64}, year = {2025}, }
• (2025). Four-state electrochromism in tris(4-aminophenyl)amine- terephthalaldehyde-based covalent organic framework. ANGEW, 64(4), e202416046. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) are of massive interest due to their potential application spanning diverse fields such as gas storage and separation, catalysis, drug delivery systems, sensing, and organic electronics. In view of their application-oriented quest, the field of electrochromism marked a significant stride with the reporting of the first electrochromic COF in 2019 [ J. Am. Chem. Soc. 2019, 141, 19831–19838 ]. Since then, new and novel COF structures with electrochromic features (denoted as ec COFs) have been searched continuously. Yet, only a handful of ec COFs have been constructed to date. A closer look at these reports suggests that multielectrochromism (showing at least three redox color states) in a COF assembly has only been achieved once, manifested through three-state electrochromism [ Angew. Chem. 2021, 133, 12606–1261 ]. Herein, we report four-state electrochromism in tris(4-aminophenyl)amine-terephthalaldehyde (TAPA-PDA)-based COF constructed through the metal-catalyst free Schiff base approach. The four-state (orange, pear, green, and cyan) electrochromism demonstrated by the TAPA-PDA ec COF opens several futuristic avenues for ec COF′s end use in flip-flop logic gates, intelligent windows, decorative displays, and energy-saving devices.}, archive = {J_ANGEW}, author = {Gaurav Kumar Silori and Szu-Chia Chien and Li-Chiang Lin and Kuo-Chuan Ho}, doi = {10.1002/anie.202416046}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416046}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Four-state electrochromism in tris(4-aminophenyl)amine- terephthalaldehyde-based covalent organic framework}, volume = {64}, year = {2025}, }
• (2025). Organocatalytic asymmetric construction of 2,6-diazabicyclo-[2.2.2]octanes by harnessing the potential of an 3-oxindolium ion intermediate. ANGEW, 64(4), e202416042. (www)

  @article{ , abstract = {Due to its structural complexity and intrinsic sensitivity of bridged aminal junction, 2,6-diazabicyclo[2.2.2]octane (2,6-DABCO) has remained a highly desirable target in synthetic chemistry. However, the asymmetric access to this unit is still insufficient and hampered by the need for meticulously created functionalities for intricate double aza-cyclizations. Herein, we have developed a novel enantio- and diastereoselective protocol to access polycyclic chiral 2,6-DABCOs under metal-free conditions. This domino process involves the amine-catalyzed [4+2] annulation between glutaraldehyde and 2-arylindol-3-ones, followed by an acid-mediated Pictet–Spengler reaction/intramolecular aza-cyclization cascade sequence with tryptamine by trapping of in situ generated 3-oxindolium ion intermediate for the first time. Overall, 2,6-DABCOs fused with medicinally relevant scaffolds were isolated with good yield and excellent stereoselectivity by constructing five new bonds and four stereocenters in a one-pot operation.}, archive = {J_ANGEW}, author = {Jyothi Yadav and Arun Patel and Atul Jankiram Dolas and Eldhose Iype and Krishnan Rangan and Indresh Kumar}, doi = {10.1002/anie.202416042}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416042}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organocatalytic asymmetric construction of 2,6-diazabicyclo-[2.2.2]octanes by harnessing the potential of an 3-oxindolium ion intermediate}, volume = {64}, year = {2025}, }
• (2025). Synthesis and anisotropic memristive behavior of borophene nanosheets. ANGEW, 64(4), e202416041. (www)

  @article{ , abstract = {Neuromorphic computing, marked by its parallel computational abilities and low power usage, has become pivotal in advancing artificial intelligence. However, the advancement of neuromorphic computing has faced significant obstacles due to the performance limitations of traditional memory devices struggling with high power consumption and limited reliability. Two-dimensional (2D) materials have been extensively investigated as high-performance memristive materials, but they are often restricted by fixed memristive properties, which complicate circuit design and limit flexibility. Here, we report that multilayer borophene nanosheets represent a breakthrough material, displaying anisotropic variable memristive properties. The nanosheets, comprising semiconductor α’-4H-borophene sheets and metal β 12 -borophene sheets, have been synthesized on aluminum foil surface through chemical vapor deposition method. The multilayer borophene nanosheets exhibit volatile memory behavior in the vertical direction and non-volatile memory behavior in the planar direction. This innovative class of 2D nanosheets not only overcomes the limitations of conventional memory devices but also expands the potential applications of borophene-based memories in information storage and in-memory computing.}, archive = {J_ANGEW}, author = {Zitong Wu and Xinchao Liang and Yi Liu and Maoping Xu and Rui Zhu and Guoan Tai}, doi = {10.1002/anie.202416041}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416041}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and anisotropic memristive behavior of borophene nanosheets}, volume = {64}, year = {2025}, }
• (2025). In situ synthesis of MoO3 by surface oxidation of Mo2C (MXene) for stable near-surface reactions in aqueous aluminum-ion battery. ANGEW, 64(4), e202416032. (www)

  @article{ , abstract = {Molybdenum trioxide (MoO 3 ) is a promising positive electrode material for aqueous aluminum-ion batteries (AAIBs) due to its high theoretical capacity. However, MoO 3 faces several challenges in an aqueous electrolyte, such as easy dissolution of reaction products, volume expansion, and low conductivity, which severely limit its application in aqueous batteries. In this work, we effectively increased the overall conductivity of the electrode by in situ growing MoO 3 on the Mo 2 C MXene layer. MXene can effectively inhibit the dissolution and structural loss of MoO 3 reaction products. Additionally, the coordination effect of Mo 2 C and MoO 3 achieves a stable near-surface reaction on the MXene laminates, resulting in the Mo 2 C/MoO 3 composite exhibiting excellent aluminum storage properties (123.5 mAh/g after 200 cycles at 0.4 A/g). The energy storage mechanism of H + /Al 3+ co-insertion/extraction was elucidated through ex situ characterization, and the promotion effect of Mo 2 C on MoO 3 reaction kinetics was verified by density functional theory (DFT) calculations. This work provides new insights into improving the stability of AAIBs cathodes and extends the application of Mo-based MXene in aqueous batteries.}, archive = {J_ANGEW}, author = {Yi Wang and Tanci Wu and Yong Lu and Wenming Zhang and Zhanyu Li}, doi = {10.1002/anie.202416032}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416032}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ synthesis of MoO3 by surface oxidation of Mo2C (MXene) for stable near-surface reactions in aqueous aluminum-ion battery}, volume = {64}, year = {2025}, }
• (2025). Structural snapshots, trajectory and thermodynamics of the reversible μ-1,2-peroxo/μ-1,1-hydroperoxo Dicopper(II) interconversion. ANGEW, 64(4), e202416022. (www)

  @article{ , abstract = {Hydrogen bonds involving the oxygen atoms of intermediates that result from copper-mediated O 2 activation play a key role for controlling the reactivity of Cu x /O 2 active sites in metalloenzymes and synthetic model complexes. However, structural insight into H-bonding in such transient species as well as thermodynamic information about proton transfer to or from the O 2 -derived ligands is scarce. Here we present a detailed study of the reversible interconversion of a μ 1,2 -peroxodicopper(II) complex ([ 1 ] + ) and its μ 1,1 -hydroperoxo congener ([ 2 ] + ) via (de)protonation, including the isolation and structural characterization of several H-bond donor (HBD) adducts of [ 1 ] + and the determination of binding constants. For one of these adducts a temperature-dependent μ 1,2 -peroxo/μ 1,1 -hydroperoxo equilibrium associated with reversible H + -translocation is observed, its thermodynamics investigated experimentally and computationally, and effects of H-bonding on spectroscopic parameters of the Cu II 2 (μ 1,2 -O 2 ) species are revealed. DFT calculations allowed to fully map and correlate the trajectories of H + -transfer and μ 1,2 -peroxo→μ 1,1 -peroxo rearrangement. These findings enhance our understanding of two key intermediates in bioinspired Cu 2 /O 2 chemistry.}, archive = {J_ANGEW}, author = {Can-Jerome Spyra and David Hiller and Kim A. Eisenlohr and Sebastian Dechert and Serhiy Demeshko and Disha Bhattacharya and Jana Lücken and Max C. Holthausen and Franc Meyer}, doi = {10.1002/anie.202416022}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416022}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural snapshots, trajectory and thermodynamics of the reversible μ-1,2-peroxo/μ-1,1-hydroperoxo Dicopper(II) interconversion}, volume = {64}, year = {2025}, }
• (2025). Enhancement of NIR-II emission of er3+ by doping fe3+ in double perovskites: Multimode luminescence for versatile optoelectronic applications. ANGEW, 64(4), e202416021. (www)

  @article{ , abstract = {Erbium ions are commonly used to extend the photoelectric properties of metal halide perovskites from visible to near-infrared range. However, achieving high-efficiency multimode luminescence in a single system is difficult due to the weak absorption associated with forbidden 4 f -4 f transitions. In this study, a unique strategy is proposed to adjust multimode luminescence and enhance the second near-infrared region (NIR-II) emission in Cs 2 NaBiCl 6 by incorporating Fe 3+ ions. The as-prepared material demonstrates reversible thermochromism, driven by strong electron-phonon coupling effect, and exhibits tunable luminescence that can be adjusted by altering excitation energy and temperature. Notably, benefitting from the charge transfer transition of Fe 3+ -Cl − along with the influence of Fe 3+ doping on the geometrical and electronic structures, the blue-excitable (450 nm) NIR-II emission around 1541 nm from Er 3+ is realized for the first time, achieving an intensity 16.7 times higher and a maximum photoluminescence quantum yield (PLQY) of 22.5 %. This enhancement enables innovative applications such as two-dimensional information encryption by the multi-channel cooperative responses and improved NIR imaging. The study highlights the potential of Fe 3+ doping in optimizing absorption and multimode luminescence in perovskites, opening avenues for advanced applications in blue-excitable NIR light emitting diodes (LEDs), thermometer, anti-counterfeiting, and NIR imaging.}, archive = {J_ANGEW}, author = {Yingsheng Wang and Bibo Lou and Peipei Dang and Guodong Zhang and Yujia Wan and Long Tian and Hongzhou Lian and Zhiyao Hou and Chonggeng Ma and Guogang Li and Jun Lin}, doi = {10.1002/anie.202416021}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416021}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancement of NIR-II emission of er3+ by doping fe3+ in double perovskites: Multimode luminescence for versatile optoelectronic applications}, volume = {64}, year = {2025}, }
• (2025). Inner side chain modification of small molecule acceptors enables lower energy loss and high efficiency of organic solar cells processed with non-halogenated solvents. ANGEW, 64(4), e202416016. (www)

  @article{ , abstract = {Organic solar cells (OSCs) processed with non-halogenated solvents usually suffer from excessive self-aggregation of small molecule acceptors (SMAs), severe phase separation and higher energy loss ( E loss ), leading to reduced open-circuit voltage ( V oc ) and power conversion efficiency (PCE). Regulating the intermolecular interaction to disperse the aggregation and further improve the molecular packing order of SMAs would be an effective strategy to solve this problem. Here, we designed and synthesized two SMAs L8-PhF and L8-PhMe by introducing different substituents (fluorine for L8-PhF and methyl for L8-PhMe) on the phenyl end group of the inner side chains of L8-Ph, and investigated the effect of the substituents on the intermolecular interaction of SMAs, E loss and performance of OSCs processed with non-halogenated solvents. Through single crystal analysis and theoretical calculations, it is found that compared with L8-PhF, which possesses strong and abundant intermolecular interactions but downgraded molecular packing order, L8-PhMe with the methyl substituent possesses more effective non-covalent interactions, which improves the tightness and order of molecular packing. When blending the SMAs with polymer donor PM6, the differences in intermolecular interactions of the SMAs influenced the film formation process and phase separation of the blend films. The L8-PhMe based blend film exhibits shorten film formation and more homogeneous phase separation than those of the L8-PhF and L8-Ph based ones. Especially, the OSCs based on L8-PhMe show reduced non-radiative energy loss and enhanced V oc than the devices based on the other two SMAs. Consequently, the L8-PhMe based device processed with o -xylene ( o -XY) and using 2PACz as the hole transport layer (HTL) shows an outstanding PCE of 19.27 %. This study highlights that the E loss of OSCs processed with non-halogenated solvents could be decreased through regulating the intermolecular interactions of SMAs by inner side chain modification, and also emphasize the importance of effectivity rather than intensity of non-covalent interactions introduced in SMAs on the molecular packing, morphology and PCE of OSCs.}, archive = {J_ANGEW}, author = {Xiangxi Wu and Yufei Gong and Xiaojun Li and Shucheng Qin and Haozhe He and Zekun Chen and Tongling Liang and Caixuan Wang and Dan Deng and Zhaozhao Bi and Wei Ma and Lei Meng and Yongfang Li}, doi = {10.1002/anie.202416016}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416016}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inner side chain modification of small molecule acceptors enables lower energy loss and high efficiency of organic solar cells processed with non-halogenated solvents}, volume = {64}, year = {2025}, }
• (2025). Label-free raman probing of the intrinsic electric field for high-efficiency screening of electricity-producing bacteria at the single-cell level. ANGEW, 64(4), e202416011. (www)

  @article{ , abstract = {The fabrication of high-performance microbial fuel cells requires the evaluation of the activity of electrochemically active bacteria. However, this is challenging because of the time-consuming nature of biofilm formation and the invasive nature of labeling. To address this issue, we developed a fast, label-free, single-cell Raman spectroscopic method. This method involves investigating the “pure” linear Stark effect of endogenous CO in the silent region of biological samples, which allows for probing the intrinsic electric field in the outer-membrane cytochromes of live bacterial cells. We found that reduced outer-membrane cytochromes can generate an additional intrinsic electric field equivalent to an applied potential of +0.29 V. We also found that the higher the electrical activity of the cell, the larger the generated electric field. This was also reflected in the output current of the constructed microbial fuel cells. Raman spectroscopy was employed to facilitate the assessment of electrochemical activity at the single-cell level in highly-diluted bacterial samples. After analysis, inactive bacteria were ablated by laser heating, and 20 active cells were cultured for further testing. The rapid and high-throughput probing of the intrinsic electric field offers a promising platform for high-efficiency screening of electrochemically active bacterial cells for bioenergetic and photosynthetic research.}, archive = {J_ANGEW}, author = {Xueqin Chen and Yan Gao and Yongbing Qi and Jinxiang Li and Tony Y. Hu and Zixuan Chen and Jun-Jie Zhu}, doi = {10.1002/anie.202416011}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416011}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Label-free raman probing of the intrinsic electric field for high-efficiency screening of electricity-producing bacteria at the single-cell level}, volume = {64}, year = {2025}, }
• (2025). Intracellular redox environment determines cancer-normal cell selectivity of selenium nanoclusters. ANGEW, 64(4), e202416006. (www)

  @article{ , abstract = {Elucidating the chemical structure and intracellular action mechanisms is still the critical limit for the clinical translation of nanomedicines. Intracellular redox environments originating from cell metabolism are key factors affecting internalized drug efficacy. Herein, we engineer Se−Se/Se−S bond to assemble selenium (Se) nanoclusters (SeClus) with intracellular redox environment-driven selective structure. Chemical structure analysis reveals that, the bonding of sulfur atom in intermediates to the two neighboring or interposition Se atoms in Se rings is the key internal driving force for SeClus formation. This nanocluster can be predominantly transformed to selenocysteine to facilitate selenoproteins synthesis in normal cells, while metabolize to cytotoxic SeO 3 2− based on the oxidative intracellular redox environment of cancer cells. Resultantly, SeClus exhibit significant cell proliferation inhibition ability to cancer cells and impressive safety to normal cells. Taken together, this study not only clarifies the chemical nature of the atom engineering of SeClus, but also elucidates its intracellular redox environment-oriented anticancer mechanism.}, archive = {J_ANGEW}, author = {Zushuang Xiong and Lizhen He and Fen Pi and Yanzi Yu and Zhirong Xiao and Tianfeng Chen}, doi = {10.1002/anie.202416006}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416006}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intracellular redox environment determines cancer-normal cell selectivity of selenium nanoclusters}, volume = {64}, year = {2025}, }
• (2025). Bead-based DNA synthesis and sequencing for integrated data storage using digital microfluidics. ANGEW, 64(4), e202416004. (www)

  @article{ , abstract = {DNA is considered as a prospective candidate for the next-generation data storage medium, due to its high coding density, long cold-storage lifespan, and low energy consumption. Despite these advantages, challenges remain in achieving high-fidelity, fully integrated, and cost-efficient DNA storage system. In this study, a homemade digital microfluidic (DMF)-based compact DNA data storing pipeline is orchestrated to complete the entire process from the synthesis to the sequencing. The synthetic half employs phosphoramidite chemistry on 200 nm magnetic beads (MBs), where the dimethyltrityl protecting group is removed by droplet manipulation of trichloroacetic acid. The sequencing counterpart relies on pyrophosphate releasing originated from polymerase-catalyzed primer extension, which leads to photon-countable chemiluminescence (CL) signal in 2.5-μL drops of trienzyme cascading reactions. Further by DNA denaturation, repeated pyrosequencing plus plurality voting can improve the nucleobase accuracy beyond 95 %. As a proof-of-concept trial, semantic information is saved in DNA via the Huffman coding algorithm plus the Reed-Solomon error-correction, and then robustly retrieved from this streamlined platform. As a result, it took a net total of approximately 6.5 h to writing and reading 8 bytes of data, that equal to a storaging speed of 49 min/byte, much quicker than the previously reported 2.8–4.2 h/byte. This bead-based miniaturized device promises an unattended protocol for achieving high-throughput, full-packaged, and above all, neatly precision DNA storage.}, archive = {J_ANGEW}, author = {Yuhao Piao and Yitong Fang and Bin Li and Tiantian Man and Jie Chen and Fulin Zhu and Weiqiang Wang and Ying Wan and Shengyuan Deng}, doi = {10.1002/anie.202416004}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416004}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bead-based DNA synthesis and sequencing for integrated data storage using digital microfluidics}, volume = {64}, year = {2025}, }
• (2025). Molecular imaging of renin activity using fluorogenic nanoprobes for precision antihypertensive therapy. ANGEW, 64(4), e202416002. (www)

  @article{ , abstract = {Life-threatening hypertension remains inadequately controlled in clinics due to its heterogeneous renin levels. Rapid stratification of hypertension through renin analysis is crucial for effective personalized treatment, yet an ultrasensitive detection approach is currently lacking. Here, we report activatable renin nanoprobes (ARNs) for non-invasive and ultrasensitive profiling of renin activity and guiding antihypertensive treatment decision through near-infrared fluorescence (NIRF) in vivo imaging and in vitro urinalysis. ARNs are intrinsically non-fluorescent due to NIRF reporter connected to a gold nanocluster through a renin-responsive peptide. In hyperreninemia mouse models, ARNs specifically react with renin to liberate the renal clearable NIRF reporter for accurate renin detection that outperforms the gold standard radioimmunoassay. Such specific and sensitive detection also enables imaging-based high-throughput screening of antihypertensive drugs. In hypertensive rat models, ARNs enable ultrasensitive detection of both plasma and urinary renin, facilitating renin-guided precision treatment and significantly improving hypertension control rate (90 % versus 58 %). Our nanoprobe platform holds great potential for assisting clinicians in rapidly and accurately classifying hypertensive patients and improving outcomes through tailored treatment selection.}, archive = {J_ANGEW}, author = {Ya Zhou and Weiping Xu and Bankang Ruan and Lijuan Zhu and Yuyan Jiang and Hui Cai and Jiaguo Huang}, doi = {10.1002/anie.202416002}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202416002}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular imaging of renin activity using fluorogenic nanoprobes for precision antihypertensive therapy}, volume = {64}, year = {2025}, }
• (2025). Quantum spin exchange interactions trigger o p band broadening for enhanced aqueous zinc-ion battery performance. ANGEW, 64(4), e202415997. (www)

  @article{ , abstract = {The pressing demand for large-scale energy storage solutions has propelled the development of advanced battery technologies, among which zinc-ion batteries (ZIBs) are prominent due to their resource abundance, high capacity, and safety in aqueous environments. However, the use of manganese oxide cathodes in ZIBs is challenged by their poor electrical conductivity and structural stability, stemming from the intrinsic properties of MnO 2 and the destabilizing effects of ion intercalation. To overcome these limitations, our research delves into atomic-level engineering, emphasizing quantum spin exchange interactions (QSEI). These essential for modifying electronic characteristics, can significantly influence material efficiency and functionality. We demonstrate through density functional theory (DFT) calculations that enhanced QSEI in manganese oxides broadens the O p band, narrows the band gap, and optimizes both proton adsorption and electron transport. Empirical evidence is provided through the synthesis of Ru−MnO 2 nanosheets, which display a marked increase in energy storage capacity, achieving 314.4 mAh g −1 at 0.2 A g −1 and maintaining high capacity after 2000 cycles. Our findings underscore the potential of QSEI to enhance the performance of TMO cathodes in ZIBs, pointing to new avenues for advancing battery technology}, archive = {J_ANGEW}, author = {Shiyu Wang and Shuyun Yao and Feike Zhang and Kang Ji and Yingjie Ji and Jingxian Li and Weijie Fu and Yuanming Liu and Jinghua Yang and Ruilong Liu and Jiangzhou Xie and Zhiyu Yang and Yi-Ming Yan}, doi = {10.1002/anie.202415997}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415997}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantum spin exchange interactions trigger o p band broadening for enhanced aqueous zinc-ion battery performance}, volume = {64}, year = {2025}, }
• (2025). Linker-mediated delocalized excited states in dimeric acceptors enable efficient exciton dissociation with negligible energy-level offsets. ANGEW, 64(4), e202415994. (www)

  @article{ , abstract = {Efficient exciton dissociation at low energy offsets is key to overcoming voltage losses in organic solar cells. In this work, we developed two dimeric acceptors, i-YT and o-YT, by precisely controlling the position of an asymmetric electron-donating linker. It induced the foldamer conformation of i-YT with a para linkage (relative to the dicyano groups), while retaining the unfold conformation for o-YT. This subtle structural modification influenced the molecular assembly properties, enabled near-zero energy offset exciton dissociation and power conversion efficiencies exceeding 18 % for i-YT based organic solar cells. Detailed excitonic dynamics further revealed that the linker position critically influences three processes: the formation of delocalized singlet excited states, ultrafast charge transfer (~5 ps) in solid blends, and the suppression of exciton recombination. Additionally, devices based on i-YT demonstrated outstanding long-term stability, retaining 85 % of their initial efficiency after 1,400 hours of continuous illumination. These findings introduce a new class of dimeric acceptors that combine high efficiency with exceptional stability, offering a promising pathway toward low-energy-loss organic photovoltaics.}, archive = {J_ANGEW}, author = {Sheng-Yu Shi and Chao Yang and Xinjie Xu and Zhi-Xi Liu and Wanchun Duan and Xing-Xing Chen and Zhou Lu and Hongping Zhou and Zhi-Peng Yu and Chang-Zhi Li}, doi = {10.1002/anie.202415994}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415994}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Linker-mediated delocalized excited states in dimeric acceptors enable efficient exciton dissociation with negligible energy-level offsets}, volume = {64}, year = {2025}, }
• (2025). Single-molecule conductance of staffanes. ANGEW, 64(4), e202415978. (www)

  @article{ , abstract = {We report the first conductance measurements of [ n ]staffane (bicyclopentane) oligomers in single-molecule junctions. Our studies reveal two quantum transport characteristics unique to staffanes that emerge from their strained bicyclic structure. First, though staffanes are composed of weakly conjugated C−C σ -bonds, staffanes carry a shallower conductance decay value (β=0.84±0.02 n −1 ) than alkane chain analogs ( β =0.96±0.03 n −1 ) when measured with the scanning tunneling microscopy break junction (STM-BJ) technique. Staffanes are thus more conductive than other σ -bonded organic backbones reported in the literature on a per atom basis. Density functional theory (DFT) calculations suggest staffane backbones are more effective conduits for charge transport because their significant bicyclic ring strain destabilizes the HOMO-2 energy, aligning it more closely with the Fermi energy of gold electrodes as oligomer order increases. Second, the monostaffane is significantly lower conducting than expected. DFT calculations suggest that short monostaffanes sterically enforce insulating gauche interelectrode orientations over syn orientations; these steric effects are alleviated in longer staffanes. Moreover, we find that [2-5]staffane wires may accommodate axial mechanical strain by “rod-bending”. These findings show for the first time how bicyclic ring strain can enhance charge transmission in saturated molecular wires. These studies showcase the STM-BJ technique as a valuable tool for uncovering the stereoelectronic proclivities of molecules at material interfaces.}, archive = {J_ANGEW}, author = {Ashley E. Pimentel and Lan D. Pham and Veronica Carta and Timothy A. Su}, doi = {10.1002/anie.202415978}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-molecule conductance of staffanes}, volume = {64}, year = {2025}, }
• (2025). Light-activated reactivity of nitrones with amino acids and proteins. ANGEW, 64(4), e202415976. (www)

  @article{ , abstract = {Controlled modifications of amino acids are an indispensable tool for advancing fundamental and translational research based on peptides and proteins. Yet, we still lack methods to chemically modify each naturally occurring amino acid sidechain. To help address this gap, we show that N , α -diaryl oxaziridines expand the scope of bioconjugation methods to chemically modify cysteine, methionine, and tryptophan residues with evidence for additional tyrosine labelling in a proteomic context. Conjugation primarily at tryptophan sites can be accessed by selective cleavage of modifications at other sidechains. The N , α -diaryl oxaziridine reagents are accessed through photoisomerization of nitrones, which serve as photocaged reagents, thus providing an additional level of control over reactivity. Initial guiding principles for the design of nitrone reagents are developed by exploring the impact of structure on UV/Vis absorption, photoisomerization, and reactivity. We identify a nitrone structure that maximizes photoisomerization efficiency, the aqueous stability of the oxaziridine, the extent of amino acid modification, and the stability of the resulting amino acid conjugates. We then translate nitrone reagents to modify proteins in aqueous conditions. Finally, we use nitrones to profile reactive residues across the proteome of a mammalian cell line and find that they expand the proteome coverage.}, archive = {J_ANGEW}, author = {Kacper Skakuj and Maximilian Iglhaut and Qian Shao and Francisco J. Garcia and Bo-Yang Huang and Scott M. Brittain and Alexey I. Nesvizhskii and Markus Schirle and Daniel K. Nomura and F. Dean Toste}, doi = {10.1002/anie.202415976}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415976}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-activated reactivity of nitrones with amino acids and proteins}, volume = {64}, year = {2025}, }
• (2025). Electrochemical nitrate reduction to ammonia on AuCu single-atom alloy aerogels under wide potential window. ANGEW, 64(4), e202415975. (www)

  @article{ , abstract = {Electrocatalytic nitrate reduction to ammonia (NO 3 RR) is very attractive for nitrate removal and ammonia production in industrial processes. However, the nitrate reduction reaction is characterized by intense hydrogen competition at strong reduction potentials, which greatly limits the Faraday efficiency at strong reduction potentials. Herein, we reported an Au x Cu single-atom alloy aerogels (Au x Cu SAAs) with three-dimensional network structure with significant nitrate reduction performance of Faraday efficiency (FE) higher than 90 % over a wide potential range (0 ~ −1 V RHE ). The FE of the catalyst was close to 100 % at a high reduction potential of −0.8 V RHE , accompanying with NH 3 yield reaching 6.21 mmol h <M−>1 cm <M−>2 . More importantly, the catalyst maintained a long-term operation over 400 h at 400 mA cm <M−>2 for the NO 3 RR using a continuous flow system in a H-cell. Experimental and theoretical analysis demonstrate that the catalyst can lower the energy barrier for the hydrogenation reaction of *NO 2 , leading to a rapid consumption of the generated *H, facilitate the hydrogenation process of NO 3 RR, and inhibit the competitive HER at high overpotentials, which efficiently promotes the nitrate reduction reaction, especially in industrial applications.}, archive = {J_ANGEW}, author = {Jidong Yu and Rui-Ting Gao and Xiaotian Guo and Nhat Truong Nguyen and Limin Wu and Lei Wang}, doi = {10.1002/anie.202415975}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415975}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical nitrate reduction to ammonia on AuCu single-atom alloy aerogels under wide potential window}, volume = {64}, year = {2025}, }
• (2025). A 3D robust and microporous B←N framework with 8-connected sandwich nodes for efficient separation of hexane isomers. ANGEW, 64(4), e202415968. (www)

  @article{ , abstract = {Recently B←N organic frameworks (BNFs) have gained substantial attention owing to their unique dative bond energy, which imparts them with specialized functionalities across a broad spectrum of applications. Despite previous reports on BNFs with permanent porosity, research endeavors towards three-dimensional (3D) BNFs with similar properties are scarce, with no report of robust 3D BNFs featuring permanent porosity to date. Herein, electrostatic complementary strategy is proposed to construct the first example of 3D robust and microporous BNF, BNF-100 , featuring a reo topology with 8-connected sandwich nodes assembled via dative B←N bonds. The activated form BNF-100 a exhibits excellent chemical stability and permanent porosity with Langmuir surface area of 645.9 m 2 g −1 and pore volume of 0.23 cm 3 g −1 . BNF-100 a can efficiently separate hexane isomers through sieving mechanisms, as confirmed by vapor adsorption experiments and dynamic breakthrough tests, surpassing the performance of most MOF materials. Finally, we achieved the purification of different branched hexane isomers using a single breakthrough column in a combined breakthrough and purging experiment, which is the first reported instance in the literature on hexane isomer separation.}, archive = {J_ANGEW}, author = {Hongyu Lin and Hao Zhang and Yunbin Li and Furong Yuan and Xiaoqing Zheng and Lei He and Lu Li and Yongfan Zhang and Shengchang Xiang and Banglin Chen and Zhangjing Zhang}, doi = {10.1002/anie.202415968}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415968}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A 3D robust and microporous B←N framework with 8-connected sandwich nodes for efficient separation of hexane isomers}, volume = {64}, year = {2025}, }
• (2025). Chemical synergic stabilization of high br-content mixed-halide wide-bandgap perovskites for durable multi-terminal tandem solar cells with minimized pb leakage. ANGEW, 64(4), e202415966. (www)

  @article{ , abstract = {High Br-content lead mixed-halide perovskites with wide-bandgap (WBG) of 1.6–2.0 eV have showcased vast potential to be used in tandem solar cells. However, WBG perovskites often suffer from severe halide segregation, phase separation and ion migration under the stress of light, heat, moisture and electric bias, which would accelerate the decomposition of perovskite films and thus deteriorate the photovoltaic performance and even aggravate the lead leakage from damaged devices. Here, we report a novel chemical synergic interaction strategy to mitigate the abovementioned issues in WBG perovskites. To achieve that, a small amount of cationic β-cyclodextrin, composed of multiple ammonium cations, chlorine ions and abundant hydroxyl functional groups, was introduced into WBG perovskites, which effectively stabilized the halide ions and homogenized the phase distribution, comprehensively passivated the crystallographic defects, as well as efficiently immobilized the Pb 2+ ions. Encouragingly, the cationic β-cyclodextrin was universal and useful for different WBG perovskite compositions (i.e. 1.68 eV, 1.79 eV and 1.99 eV), which favorably boosted the efficiencies by 10 %–36 % and extended the operational stability of resultant devices to 2680 h. The four-terminal all-perovskite tandem and six-terminal all-perovskite tandem solar cells integrated with different WBG perovskite sub-cells exhibited efficiencies up to 24.39 % and 22.42 %, respectively. More importantly, we demonstrated the cationic β-cyclodextrin-assisted internal chemical encapsulation effectively prevented the Pb leakage when the devices were severely damaged and immersed in water. Surprisingly, there was only 5.63 ppb Pb leaching out for the single-junction devices, far below than the U.S. standard for safe drinking water (<15 ppb). The target tandem solar cells with cationic β-cyclodextrin modification also realized a Pb sequestration efficiency of 93.4 % under the most adverse environment.}, archive = {J_ANGEW}, author = {Meifang Yang and Ying Tan and Guo Yang and Xueqing Chang and Tian Tian and Wen-Guang Li and Yuxuan Fang and Jinliang Shen and Shaopeng Yang and Wu-Qiang Wu}, doi = {10.1002/anie.202415966}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415966}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemical synergic stabilization of high br-content mixed-halide wide-bandgap perovskites for durable multi-terminal tandem solar cells with minimized pb leakage}, volume = {64}, year = {2025}, }
• (2025). Second generation zwitterionic aza-diarylethene: Photoreversible CN bond formation, three-state photoswitching, thermal energy release, and facile photoinitiation of polymerization. ANGEW, 64(4), e202415961. (www)

  @article{ , abstract = {Diarylethenes are a well-studied and optimized class of photoswitches with a wide range of applications, including data storage, smart materials, or photocontrolled catalysis and biological processes. Most recently, aza-diarylethenes have been developed in which carbon-carbon bond connections are replaced by carbon-nitrogen connections. This structural elaboration opens up an entire new structure and property space expanding the versatility and applicability of diarylethenes. In this work, we present the second generation of zwitterionic aza-diarylethenes, which finally allows for fully reversible photoswitching and precise control over all three switching states. High-yielding photoswitching between the neutral open form and a zwitterionic Z isomer is achieved with two different wavelengths of light. The third zwitterionic E isomeric state can be reached in up to 87 % upon irradiation with a third wavelength. Its high energy content of >10 kcal/mol can be released thermally by deliberate solvent change as trigger mechanism, rendering aza-diarylethenes into interesting candidates for molecular solar thermal energy storage (MOST) applications. The third state also serves as locking state, allowing to toggle light-responsiveness reversibly between thermally labile and thermally stable switching. Further, irradiation of the zwitterionic states leads to highly efficient photopolymerization of methyl acrylate (MA), directly harnessing the unleashed chemical reactivity of our aza-diarylethene in a materials application.}, archive = {J_ANGEW}, author = {Maximilian Sacherer and Henry Dube}, doi = {10.1002/anie.202415961}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415961}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Second generation zwitterionic aza-diarylethene: Photoreversible CN bond formation, three-state photoswitching, thermal energy release, and facile photoinitiation of polymerization}, volume = {64}, year = {2025}, }
• (2025). Revealing and inhibiting the facet-related ion migration for efficient and stable perovskite solar cells. ANGEW, 64(4), e202415949. (www)

  @article{ , abstract = {Ion migration is a major issue hindering the long-term stability of perovskite solar cells (PSCs). As an intrinsic characteristic of metal halide perovskite materials, ion migration is closely related to the atomic arrangement and coordination, which are the basic characteristic differences among various facets. Herein, we report the facet-related ion migration, and then achieve the inhibition of ion migration in perovskite through finely modulating the facet orientation. We show that the (100) facet is substantially more vulnerable to cationic migration than the (111) facet. The main reason for this difference in migration is that the cationic migration route in the (111) facet deviates from that in the (100) facet, which increases the active migration energy and weakens the contribution from the electric field during operation. We prepare a (111)-dominated perovskite film by incorporating a facile and green addition of water (H 2 O) into the antisolvent, further achieving a power conversion efficiency (PCE) of 26.0 % (25.4 % certification) on regular planar PSCs and 25.8 % on inverted PSCs. Moreover, the unencapsulated PSCs can maintain 95 % of their initial PCE after 3500-hours operation under simulated AM1.5 illumination at the maximum power point.}, archive = {J_ANGEW}, author = {Shujie Qu and Hao Huang and Jinhui Wang and Peng Cui and Yiyi Li and Min Wang and Liang Li and Fu Yang and Changxu Sun and Qiang Zhang and Pengkun Zhu and Yi Wang and Meicheng Li}, doi = {10.1002/anie.202415949}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revealing and inhibiting the facet-related ion migration for efficient and stable perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Boron-doped single-molecule van der waals diode. ANGEW, 64(4), e202415940. (www)

  @article{ , abstract = {Single-molecule diode was the first proposed device in molecular electronics. Despite the great efforts and advances over 50 years, the reported rectification ratios, the most critical parameter of a diode, remain moderate for the single-molecule diode. Herein, we report an approach to achieve a larger rectification ratio by adopting the combined strategies of p-type boron doping, the single-layer graphene nodes, and the van der Waals layer-by-layer architecture. Measured current–voltage curves showed one of the as-fabricated single-molecule diodes hit an unprecedented large rectification ratio of 457 at ±1 V. Break junction operations and spectroscopic measurements revealed the three-atom-thick configuration of the single-molecule diodes. With the experimental and theoretical calculation results, we demonstrated the doped boron atoms induced holes to redistribute the electron density, making the asymmetric coupling at positive and negative biases, and the van der Waals interaction promoted asymmetric coupling and significantly boosted diode performance.}, archive = {J_ANGEW}, author = {Yu-Ling Zou and Wenting Sun and Jiao Xun and Qing-Man Liang and Lichuan Chen and Tong-Ruo Diao and Jia Shi and De-Yin Wu and Chuandong Dou and Wenjing Hong and Zhong-Qun Tian and Yang Yang}, doi = {10.1002/anie.202415940}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415940}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boron-doped single-molecule van der waals diode}, volume = {64}, year = {2025}, }
• (2025). Controlling the mechanism of nucleation and growth enables synthesis of UiO-66 Metal–Organic framework with desired macroscopic properties. ANGEW, 64(4), e202415919. (www)

  @article{ , abstract = {By combining in situ X-ray diffraction, Zr K-edge X-ray absorption spectroscopy and 1 H and 13 C nuclear magnetic resonance (NMR) spectroscopy, we show that the properties of the final MOF are influenced by H 2 O and HCl via affecting the nucleation and crystal growth at the molecular level. The nucleation implies hydrolysis of monomeric zirconium chloride complexes into zirconium-oxo species, and this process is promoted by H 2 O and inhibited by HCl, allowing to control crystal size by adjusting H 2 O/Zr and HCl/Zr ratios. The rate-determining step of crystal growth is represented by the condensation of monomeric and oligomeric zirconium-oxo species into clusters, or nodes, with the structure identical to that in secondary building units (SBU) of UiO-66 framework. The rapid crystallization in the absence of HCl leads to formation of defective secondary building units with missing zirconium atoms, providing a pathway to control the number of defects in UiO-66 crystals. Remarkably, we have shown that assembling of the metal nodes and linkers into the UiO-66 structure is not the rate-limiting step, and the degree of deprotonation of the linker has no direct effect on the crystallization kinetics or crystal size of product.}, archive = {J_ANGEW}, author = {Mikalai A. Artsiusheuski and Nicola P. M. Casati and Adam H. Clark and Maarten Nachtegaal and René Verel and Jeroen A. van Bokhoven and Vitaly L. Sushkevich}, doi = {10.1002/anie.202415919}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415919}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Controlling the mechanism of nucleation and growth enables synthesis of UiO-66 Metal–Organic framework with desired macroscopic properties}, volume = {64}, year = {2025}, }
• (2025). Precise single-atom modification of hybrid lead chlorides for electron donor-acceptor effect and enhanced photocatalytic aerobic oxidation. ANGEW, 64(4), e202415896. (www)

  @article{ , abstract = {Hybrid lead halides show significant potential in photocatalysis due to their excellent photophysical properties, but the atomically precise modification of their organic component to achieve synergistic interactions with the lead halide units remains a great challenge. Herein, for the first time, we have employed the crystal engineering strategy to construct a class of single-atom-substituted hybrid lead halides with electron donor-acceptor (D-A) effect. The lead halide frameworks consist of 1D linear [PbCl] + chains as inorganic building units and benzoxadiazole/benzothiadiazole/ benzoselenadiazole-funtionalized dicarboxylates as linkers. The covalent bonding between the organic ligands with electron−withdrawing groups and the electron-rich lead halide units not only facilitate the charge separation, but also enhance structural robustness that is critical for photocatalysis. The D-A structured lead halides serve as highly efficient heterogeneous photooxidation catalysts, including aerobic oxidation of C(sp 3 )−H bonds, oxidative coupling of primary amines, oxidation of phenylboronic acids and selective oxidation of sulfides that are demonstrated in 30 examples. Importantly, these photooxidation reactions are able to be driven by natural sunlight and ambient air to afford quantitative yields. Moreover, our lead halide photocatalysts are successful to fix into a photocatalytic flow system, which enables the flow-type synthesis of high value-added photooxidation products on a gram scale.}, archive = {J_ANGEW}, author = {Yukong Li and Ziyi Wang and Yilin Jiang and Chao Wu and Chen Sun and Qingran Zhang and Chi Zhang and Honghan Fei}, doi = {10.1002/anie.202415896}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415896}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise single-atom modification of hybrid lead chlorides for electron donor-acceptor effect and enhanced photocatalytic aerobic oxidation}, volume = {64}, year = {2025}, }
• (2025). The Electrode/Electrolyte interface study during the electrochemical CO2 reduction in acidic electrolytes. ANGEW, 64(4), e202415894. (www)

  @article{ , abstract = {Electrochemical CO 2 Reduction (CO2R) in acidic electrolytes has gained significant attention owing to higher carbon efficiency and stability than in alkaline counterparts. However, the proton source and the role of alkali cations for CO2R are still under debate. By using rotating ring disk electrode and surface-enhanced infrared absorption spectroscopy, we find that a neutral/alkaline environment at the interface is necessary for CO2R even in acidic electrolytes. We also confirm that water molecules, rather than protons serve as the proton source for CO2R. Alkali cations in the outer Helmholtz plane activate H 2 O and promote the desorption of adsorbed carbon monoxide. Additionally, the solvated CO 2 , or CO 2 (aq), is the actual reactant for CO2R. This study provides a deeper understanding of the electrode/electrolyte interface during CO2R in acidic electrolytes and sheds light on further performance improvement of this system.}, archive = {J_ANGEW}, author = {Yao Yao and Ernest Pahuyo Delmo and Minhua Shao}, doi = {10.1002/anie.202415894}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415894}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The Electrode/Electrolyte interface study during the electrochemical CO2 reduction in acidic electrolytes}, volume = {64}, year = {2025}, }
• (2025). Integrating prelithiation and interface protection to achieve high-energy all-solid-state batteries. ANGEW, 64(4), e202415891. (www)

  @article{ , abstract = {All-solid-state batteries (ASSBs), particularly those with Li-free anodes or even anode-free configurations, have attracted extensive attention due to high safety and energy density. However, chemical-mechanical degradation typically deteriorates the cycle life and energy of Li-free anode ASSBs with the absence of Li inventory. Here, the prelithiation agent Li 5 FeO 4 (LFO) coated Ni-rich layered oxide is developed as the cathode for Li-free anode ASSBs. The coated LFO acts as an interfacial protective layer to prevent the highly oxidizing Ni-rich cathode from reacting with sulfide solid-state electrolytes (SSEs), mitigating the structural degradation of Ni-rich cathodes and the decomposition of SSE, resulting in excellent cycle life. Beneficial from the coated LFO in the cathode of the Li-free anode ASSBs, the reversible capacity improves from 174.7 mAh g −1 to 199.7 mAh g −1 , and the capacity retention is enhanced from 33.8 % to 84.8 % after 100 cycles. Additionally, an ultrahigh energy density of 440 Wh kg −1 , based on the mass of the composite cathode, Li-free anode, and SSE, is obtained in a Li-free anode all-solid-state pouch cell equipped with the LFO-coated cathode.}, archive = {J_ANGEW}, author = {Xiangqun Xu and Shiyong Chu and Sheng Xu and Haoyu Li and Chuanchao Sheng and Mingxia Dong and Shaohua Guo and Haoshen Zhou}, doi = {10.1002/anie.202415891}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415891}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating prelithiation and interface protection to achieve high-energy all-solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of chiral sulfonimidoyl fluorides facilitates stereospecific SuFEx click chemistry. ANGEW, 64(4), e202415873. (www)

  @article{ , abstract = {Sulfur-centered electrophilic ‘warheads’ have emerged as key components for chemical proteomic probes through sulfur-exchange chemistry (SuFEx) with protein nucleophiles. Among these functional groups, sulfonimidoyl fluorides (SIFs) stand out for their modifiable sites, tunable electrophilicities, and chiral sulfur-center, presenting exciting possibilities for new covalent chemical probes. However, the synthetic access to chiral SIFs has been a challenge, limiting their exploration and applications. In this study, we describe a convenient route to obtain chiral SIFs from readily available sulfenamides via a series of one-pot tandem reactions with high enantiomeric excess (ees). The resulting chiral SIFs were further converted into a diverse array of chiral S(VI) derivatives under mild conditions or in buffer solutions. Most significantly, the specificity of the chiral SIFs in protein ligation experiments underscored the critical role of sulfur-center chirality in the design and screening of more-selective covalent probes and therapeutics.}, archive = {J_ANGEW}, author = {He-sen Huang and Yi Yuan and Wei Wang and Shi-qi Zhang and Xiao-kang Nie and Wan-ting Yang and Xin Cui and Zhuo Tang and Guang-xun Li}, doi = {10.1002/anie.202415873}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415873}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of chiral sulfonimidoyl fluorides facilitates stereospecific SuFEx click chemistry}, volume = {64}, year = {2025}, }
• (2025). Reversible redox probes to determine band-edge locations and dopant concentrations of nano-TiO2 thin-films: Settling the mott-schottky conundrum. ANGEW, 64(4), e202415857. (www)

  @article{ , abstract = {Knowing the exact location of the semiconductor band-edges is key for mechanistic insights into their use for water and CO 2 photo/electrocatalysis. In this regard, a reliable strategy for nano-semiconductors did not exist yet. We demonstrate the use of reversible redox probes on nano-semiconductor electrodes to determine their band-edge locations in aqueous solutions. Rectifying current-potential (i-U) characteristics with the high work function (i.e. more positive formal potential) Fe(CN) 6 3− /Fe(CN) 6 4− redox couple yielded the exact flatband potential at various pH whereas the reversible i-U characteristics with the low work function (i.e. more negative formal potential) Ru(NH 3 ) 6 3+ /Ru(NH 3 ) 6 2+ redox couple provided the conduction band-edge location and dopant concentration for a 30 nm thin-film n-TiO 2 . The methodology can be extended to other nano-semiconductors and serves as an alternative to and goes beyond the capabilities of the Mott-Schottky procedure for bulk semiconductor electrodes.}, archive = {J_ANGEW}, author = {Divyansh Anil Khurana and Nina Plankensteiner and Bart Vermang and Philippe M. Vereecken}, doi = {10.1002/anie.202415857}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415857}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversible redox probes to determine band-edge locations and dopant concentrations of nano-TiO2 thin-films: Settling the mott-schottky conundrum}, volume = {64}, year = {2025}, }
• (2025). Enhancing carrier behavior via controlled molecular film formation engineering leads to significant improvement in electroluminescence. ANGEW, 64(4), e202415856. (www)

  @article{ , abstract = {The quality of organic thin films critically influences carrier dynamics in organic semiconductors. In neat/doped films, even tiny voids can be penetrated by water or oxygen molecules to create charge-trap states called water/oxygen-induced traps that significantly hinder carrier mobility. While the water/oxygen-induced traps in non-doped films and crystalline states have been investigated comprehensively, there is a lack of thorough examination regarding their properties in the doped state. Therefore, there is a high demand for a molecular design strategy that effectively modulates the molecular stacking behavior in doped films and practical devices and enhances the quality of these films. Herein, we proposed a versatile molecular design principle that enables the formation of “nano-cluster” structures on both the surface and interior of doped films in target molecule 10-(4-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-1′-(4-fluorophenyl)-10 H -spiro[acridine-9,9′-xanthene] ( DspiroO-F-TRZ ), which is modified with a fluorophenyl group. These “nano-cluster” structures exhibit more uniform shapes within doped films and effectively reduce defective state densities while enhancing carrier injection and transport properties, ultimately improving device performance. Notably, TADF-OLED based on DspiroO-F-TRZ demonstrates nearly twice as much efficiency as its control counterpart due to contributions from ′nano-cluster′ structure enhancements toward improved electroluminescence performance.}, archive = {J_ANGEW}, author = {Jiasen Zhang and Denghui Liu and Deli Li and Kexuan Sun and Wei Li and Yuanyuan Meng and Chang Liu and Yujie Wu and Kaibo Fang and Xilin Mu and Chunyu Liu and Shi-Jian Su and Ziyi Ge}, doi = {10.1002/anie.202415856}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415856}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing carrier behavior via controlled molecular film formation engineering leads to significant improvement in electroluminescence}, volume = {64}, year = {2025}, }
• (2025). Modulating interfacial solvation via ion dipole interactions for low-temperature and high-voltage lithium batteries. ANGEW, 64(4), e202415853. (www)

  @article{ , abstract = {Extending the stability of ether solvents is pivotal for developing low-temperature and high-voltage lithium batteries. Herein, we elucidate the oxidation behavior of tetrahydrofuran with ternary BF 4 − , PF 6 − and difluoro (oxalato) borate anions and the evolution of interfacial solvation environment. Combined in situ analyses and computations illustrate that the ion dipole interactions and the subsequent formation of ether-Li + -anion complexes in electrolyte rearrange the oxidation order of solvated species, which enhances the electrochemical stability of ether solvent. Furthermore, preferential absorption of anions on the surface of high-voltage cathode favors the formation of a solvent-deficient electric double layer and an anti-oxidation cathode electrolyte interphase, inhibiting the decomposition of tetrahydrofuran. Remarkably, the formulated electrolyte based on ternary anion and tetrahydrofuran solvent endows the LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode with considerable rate capability of 5.0 C and high capacity retention of 93.12 % after 200 cycles. At a charging voltage of 4.5 V, the Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 cells deliver Coulombic efficiency above 99 % at both 25 and −30 °C.}, archive = {J_ANGEW}, author = {Ping Liang and Jinhan Li and Yang Dong and Zhaodong Wang and Guoyu Ding and Kuiming Liu and Linlin Xue and Fangyi Cheng}, doi = {10.1002/anie.202415853}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415853}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating interfacial solvation via ion dipole interactions for low-temperature and high-voltage lithium batteries}, volume = {64}, year = {2025}, }
• (2025). Amplifying colossal thermal expansion of a martensitic molecular crystal through interlayer shear-induced side-chain liberation. ANGEW, 64(4), e202415821. (www)

  @article{ , abstract = {Molecular crystals capable of colossal thermal expansion (TE) are fascinating owing to their substantial and continuous volume changes and reasonably linear responses to temperature. This makes them promising candidates for micromachine applications. Macroscopic motion is driven by subtle yet cooperative movements of molecules that respond to the thermal motions of dynamic functional units. The study of p-TIPS-DSB presented here offers a compelling case highlighting the relationship between the degree of dynamicity of functional units and TE behavior. In its α-phase, the p-TIPS-DSB crystal undergoes an irreversible martensitic transition to the β-phase, accompanied by significant cooperative interlayer shear. This process substantially enhances the mobility of the side-chains driven by the increased free volume surrounding them. This nearly doubles the volumetric TE coefficient from 255.3 (10) to 444.9 (32) MK −1 , particularly in the actuation direction from 175.0 (7) to 291.7 (20) MK −1 , enabling about 4.5 % elongation/contraction. As demonstrated here, p-TIPS-DSB exhibits a decent force density (>1.4×10 7 N m −3 ) and precise motion control capabilities due to its hysteresis-free and non-abrupt TE nature. Furthermore, we demonstrated the limited operating distance of colossal TE materials can be amplified by utilizing levers, highlighting the high potential of these materials for use in micromachines.}, archive = {J_ANGEW}, author = {Kyoungtae Hwang and Gwangsik Sin and Minwoo Jang and Yoon Mi Choi and Dohyun Moon and Hyungbum Park and Sang Kyu Park}, doi = {10.1002/anie.202415821}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415821}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amplifying colossal thermal expansion of a martensitic molecular crystal through interlayer shear-induced side-chain liberation}, volume = {64}, year = {2025}, }
• (2025). Achieving controllable thermochromic fluorescence via synergistic intramolecular charge transfer and molecular packing. ANGEW, 64(4), e202415815. (www)

  @article{ , abstract = {Thermochromic fluorescent materials (TFMs) have attracted significant attention due to their unique fluorescent colorimetric response to temperature. However, existing TFMs still suffer from weak stimulus responsiveness, broad temperature response ranges, uncontrollable emission color changes, and low quantum yields. In this study, we address these issues by designing and synthesizing three diketone-boron complexes with distinct emission wavelengths ( NWPU-(2–4) ). Utilizing a molecular engineering strategy to manipulate intramolecular charge transfer transitions and molecular packing modes, our synthesized complexes exhibit efficient fluorescence emission in both solution and solid states. Moreover, their emission wavelengths are highly sensitive to environmental polarity. By incorporating these compounds into thermosensitive matrices of long-chain alkanes, we produced TFMs with varied fluorescence emission peak variation ranges. Notably, the TFM based on NWPU-4 , owing to its strong charge transfer transitions and dense J-aggregate packing configuration, not only exhibits intense fluorescence emission spanning the deep red to near-infrared spectrum but also displays a remarkable 90 nm broad range of thermochromic properties. Ultimately, it was successfully applied to programmable, thermally controlled, multi-level information encryption.}, archive = {J_ANGEW}, author = {Weixu Feng and Sumin Lu and Yanhui Wu and Xiaotian Li and Dong Han and Yan Zhao and Wei Tian and Hongxia Yan}, doi = {10.1002/anie.202415815}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415815}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving controllable thermochromic fluorescence via synergistic intramolecular charge transfer and molecular packing}, volume = {64}, year = {2025}, }
• (2025). Template-assisted flexible-to-rigid transition of peptides in head-to-tail self-polymerization enables sequence-controllable and post-modifiable peptide nanofibers. ANGEW, 64(4), e202415809. (www)

  @article{ , abstract = {Peptide-based nanofibers are promising materials for many essential applications and can be generalized into two categories, self-assembling peptide nanofibers (SAPNs) and poly(amino acid) nanofibers (PAANs). Non-covalent SAPNs are sequence-controllable, but poorly stable and not suitable for post-modification. While covalent PAANs are post-modifiable, however, their sequences are either monotonic or undefined. The nanofibers obtained by head-to-tail covalent coupling polymerization of sequence-known peptides, which we call series-connected peptide nanofibers (SCPNs), promise to have the advantages of both SAPNs and PAANs, but they are barely reported. The undesired backbiting effect during the head-to-tail polymerization is one of the possible challenges. Here, we present a template-assisted strategy to trigger the flexible-to-rigid transition of peptide units, which can avoid the backbiting effect and enable consecutive intermolecular polymerization of peptides to produce desired sequence-controlled covalent SCPNs. SCPNs are highly stable and can function as excellent parent materials for various post-processing to create diverse hierarchical materials independent of the peptide sequence. Moreover, SCPNs allow for the display of predetermined functional groups at regular intervals along the nanofibers by pre-modification of the initial peptide sequence. SCPNs represent a new category of peptide-based nanofibers with outstanding performances and vast potential.}, archive = {J_ANGEW}, author = {Tianzi Chen and Yin Liu and Zhanshan Gao and Yue Gao and Haijin Chen and Haonan Ye and Qiuhao Luo and Kefeng Wang and Dongdong Wu}, doi = {10.1002/anie.202415809}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415809}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Template-assisted flexible-to-rigid transition of peptides in head-to-tail self-polymerization enables sequence-controllable and post-modifiable peptide nanofibers}, volume = {64}, year = {2025}, }
• (2025). Fast seawater desalination integrated with electrochemical CO2 reduction. ANGEW, 64(4), e202415806. (www)

  @article{ , abstract = {Coupling desalination with electrocatalytic reactions is an emerging approach to simultaneously addressing freshwater scarcity and greenhouse gas emissions. However, the salt removal rate in such processes is slow, and the applicable water sources are often limited to those with high salt concentrations. Herein, we show high-performance electrocatalytic desalination by coupling with electrochemical CO 2 reduction using a carbon catalyst. A ZIF-8-derived carbon catalyst embedded with Cu nanoparticles delivers a high Faradaic efficiency of 94.3 % for CO production at 288 μmol cm −2 h −1 . The efficient CO 2 electroreduction generates high current densities, which drive fast salt ion transfer across ion exchange membranes. The integrated device enables one of the highest salt removal rates of 1043.49 μ g cm −2 min −1 among various desalination methods. Drinking water can be obtained with an ion removal rate of 99 % when natural seawater is used as the water source.}, archive = {J_ANGEW}, author = {Huiling Hu and Minxian Han and Huan Lin and Jinhong Dai and Kaixiang Shen and Minzhang Li and Xuncai Chen and Afzalshoh Qahramon Zarifzoda and Fangzhou Liu and Yuan Chen and Fuming Chen}, doi = {10.1002/anie.202415806}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415806}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fast seawater desalination integrated with electrochemical CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Direct catalytic asymmetric conjugate addition of benzofuran-3(2H)-ones to α,β-unsaturated thioamides: Stereodivergent synthesis of rocaglaol. ANGEW, 64(4), e202415805. (www)

  @article{ , abstract = {Rocaglaol, a representative flavagline, has attracted significant attention because of its unique chemical structure and biological activities. This paper reports a mild and scalable copper-catalyzed enantioselective conjugate addition of benzofuran-3(2 H )-ones to α,β-unsaturated thioamides. This method allows for the concise synthesis of all possible stereoisomers of a key intermediate of rocaglaol and its derivatives in a highly diastereo- and enantioselective manner using different chiral phosphine ligands. Theoretical insights into the reaction mechanism and the origin of ligand-dependent diastereodivergence were obtained using density functional theory calculations.}, archive = {J_ANGEW}, author = {Sadhanendu Samanta and Hidetoshi Noda and Takumi Watanabe and Jin Cui and Masakatsu Shibasaki}, doi = {10.1002/anie.202415805}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415805}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct catalytic asymmetric conjugate addition of benzofuran-3(2H)-ones to α,β-unsaturated thioamides: Stereodivergent synthesis of rocaglaol}, volume = {64}, year = {2025}, }
• (2025). Asymmetric construction of chiral 2-azetines and axially chiral tetrasubstituted allenes via phosphine catalysis. ANGEW, 64(4), e202415787. (www)

  @article{ , abstract = {Chiral 2-azetines and allenes are highly valuable structural units in natural products and useful chemicals. However, enantioselective synthesis of both 2-azetines and allenes has been extremely challenging. Herein, we present asymmetric construction of chiral 2-azetines (70–98 % yields and up to 96 % ee) through chiral phosphine-catalyzed [2+2] annulation of yne-enones with sulfamate-derived cyclic imines. These 2-azetines were easily transformed into chiral allenes upon treatment with Et 3 SiH, BF 3 ⋅ Et 2 O and water at rt for 2 minutes. Based on the above transformations, a concise one-pot synthetic procedure combining [2+2] annulation of yne-enones and sulfamate-derived cyclic imines under phosphine catalysis and sequential reduction/isomerization/ring-opening reaction through Et 3 SiH, BF 3 ⋅ Et 2 O and water was thus set up, providing axially chiral tetrasubstituted allenes in satisfactory yields and enantioselectivities (56–90 % yields and up to 91 % ee).}, archive = {J_ANGEW}, author = {Yi Tang and Mingxia Huang and Jingrong Jin and Shitao Sun and Lan Wang and Yu Tan and Xiaojing Sun and Hongchao Guo}, doi = {10.1002/anie.202415787}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415787}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric construction of chiral 2-azetines and axially chiral tetrasubstituted allenes via phosphine catalysis}, volume = {64}, year = {2025}, }
• (2025). Cognitive diversity for creativity and inclusive growth. ANGEW, 64(4), e202415695. (www)

  @article{ , abstract = {Cognitively diverse teams outperform high intelligence (IQ) teams in problem solving, while businesses with at least one woman in their board of directors financially outperform ones with all men boards. These well-known facts are lost in most academic science enterprises. Herein, we make the case for looking at sources, approaches, and opportunities in expanding cognitive diversity of research teams for high productivity and efficiency.}, archive = {J_ANGEW}, author = {Martin Thuo and Malika Jeffries-EL and James Holly and Andrew Martin and Peter Q. Blair}, doi = {10.1002/anie.202415695}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415695}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cognitive diversity for creativity and inclusive growth}, volume = {64}, year = {2025}, }
• (2025). Modular design and scaffold-synthesis of multi-functional fluorophores for targeted cellular imaging and pyroptosis. ANGEW, 64(4), e202415627. (www)

  @article{ , abstract = {Fluorophores are essential tools for optical imaging and biomedical research. Their synthetic modification to incorporate new functions, however, remains a challenging task. Conventional strategies rely on linear synthesis in which a parent framework is gradually extended. We here designed and synthesized a versatile library of multi-functional fluorophores via a scaffold-based Ugi four-component reaction (U-4CR). The adaptability of the scaffold is achieved through modification of starting materials. This allows to use a small range of starting materials for the creation of fluorogenic probes that can detect reactive-oxygen species and where the localization into subcellular organelles or membranes can be controlled. We present reaction yields ranging from 60 % to 90 % and discovered that some compounds can even function as imaging and therapeutic agents via Fenton chemistry inducing pyroptosis in living cancer cells. Our study underlines the potential of scaffold-based synthesis for versatile creation of functional fluorophores and their applications.}, archive = {J_ANGEW}, author = {Lei Zhang and Chunhui Wang and Yuanyuan Li and Haiyang Wang and Kunhui Sun and Siyu Lu and Yahui Wang and Su Jing and Thorben Cordes}, doi = {10.1002/anie.202415627}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modular design and scaffold-synthesis of multi-functional fluorophores for targeted cellular imaging and pyroptosis}, volume = {64}, year = {2025}, }
• (2025). A general hydrotrifluoromethylation of unactivated olefins enabled by voltage-gated electrosynthesis. ANGEW, 64(4), e202415218. (www)

  @article{ , abstract = {Here we present the first successful hydrotrifluoromethylation of unactivated olefins under electrochemical conditions. Commercially available trifluoromethyl thianthrenium salt (TT + −CF 3 BF 4 − , E p/2 =−0.85 V vs Fc/Fc + ) undergoes electrochemical reduction to generate CF 3 radicals which add to olefins with exclusive chemoselectivity. The resulting carbon centered radical undergoes a second cathodic reduction, instead of a classical HAT process, to generate a carbanion that can be terminated by protonation from solvent. The use of MgBr 2 (+0.20 V onset oxidation potential) plays a key role as an enabling sacrificial reductant for the reaction to operate in an undivided cell. Guided by cyclic voltammetry (CV) studies, fine-tuning the solvent system, trifluoromethylating reagent's counteranion and careful selection of redox processes, this work led to the development of a voltage-gated electrosynthesis by pairing two redox processes with a narrow potential difference (ΔE≈1.00 V) allowing the reaction to proceed with two important advances: (a) high reactivity and selectivity towards hydrotrifluoromethylation over undesired dibromination, and (b) an unprecedented functional group tolerance, including aniline, phenols, unprotected alcohol, epoxide, trialkyl amine, and several redox sensitive heterocycles.}, archive = {J_ANGEW}, author = {Eva M. Alvarez and Jinxiao Li and Christian A. Malapit}, doi = {10.1002/anie.202415218}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202415218}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A general hydrotrifluoromethylation of unactivated olefins enabled by voltage-gated electrosynthesis}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: Corrections to “Regioselective arene C−H alkylation enabled by organic photoredox catalysis”. ANGEW, 64(4), e202414447. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202414447}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202414447}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: Corrections to “Regioselective arene C−H alkylation enabled by organic photoredox catalysis”}, volume = {64}, year = {2025}, }
• (2025). Programmable C−N bond formation through radical-mediated chemistry in plasma-microdroplet fusion. ANGEW, 64(4), e202413122. (www)

  @article{ , abstract = {Non-thermal plasma discharge produced in the wake of charged microdroplets is found to facilitate catalyst-free radical mediated hydrazine cross-coupling reactions without the use of external light source, heat, precious metal complex, or trapping agents. A plasma-microdroplet fusion platform is utilized for introduction of hydrazine reagent that undergoes homolytic cleavage forming radical intermediate species. The non-thermal plasma discharge that causes the cleavage originates from a chemically etched silica capillary. The coupling of the radical intermediates gives various products. Plasma-microdroplet fusion occurs online in a programmable reaction platform allowing direct process optimization and product validation via mass spectrometry. The platform is applied herein with a variety of hydrazine substrates, enabling i) self-coupling to form secondary amines with identical N-substitutions, ii) cross-coupling to afford secondary amine with different N-substituents, iii) cross-coupling followed by in situ dehydrogenation to give the corresponding aryl-aldimines with two unique N-substitutions, and iv) cascade heterocyclic carbazole derivatives formation. These unique reactions were made possible in the charged microdroplet environment through our ability to program conditions such as reagent concentration (i. e., flow rate), microdroplet reactivity (i. e., presence or absence of plasma), and reaction timescale (i. e., operational mode of the source). The selected program is implemented in a co-axial spray format, which is found to be advantageous over the conventional one-pot single emitter electrospray-based microdroplet reactions.}, archive = {J_ANGEW}, author = {Alexander J. Grooms and Robert T. Huttner and Mackenzie Stockwell and Leah Tadese and Isabella M. Marcelo and Anthony Kass and Abraham K. Badu-Tawiah}, doi = {10.1002/anie.202413122}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202413122}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Programmable C−N bond formation through radical-mediated chemistry in plasma-microdroplet fusion}, volume = {64}, year = {2025}, }
• (2025). Subcellular compartment-specific amplified imaging of metal ions via ribosomal RNA-regulated DNAzyme sensors. ANGEW, 64(4), e202412387. (www)

  @article{ , abstract = {Although DNAzyme sensors have been widely developed for imaging metal ions, their application in specific subcellular compartments remains challenging due to low spatial controllability. Here we present a locally activatable, DNAzyme-based sensing technology that enables subcellular compartment-specific imaging of metal ions through ribosomal RNA (rRNA) regulated signal amplification. The system leverages a subcellularly encoded rRNA to locally activate DNAzyme-based sensors, and further drives signal amplification via multiple turnover cleavage of molecular beacons, to significantly enhance sensitivity and spatial precision for metal-ion imaging in specific organelles (e.g. mitochondria) or membraneless compartments (e.g. cytosol). Furthermore, we demonstrate that the system allows in situ monitoring of subcellular dynamics of mitochondrial Zn 2+ during ischemia and the drug intervention. This study expands the DNAzyme toolbox for investigating the role of subcellular metal-ion dynamics in disease processes.}, archive = {J_ANGEW}, author = {Deyu Yi and Lele Li and Mengyuan Li}, doi = {10.1002/anie.202412387}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {4}, pages = {e202412387}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Subcellular compartment-specific amplified imaging of metal ions via ribosomal RNA-regulated DNAzyme sensors}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Site-selective construction of N-linked glycopeptides through photoredox catalysis. ANGEW, 64(3), e202580362. (www)

  @article{ , archive = {J_ANGEW}, author = {Bingcheng Wei and Ping Huang and Xinyao Wang and Zhi Liu and Feng Tang and Wei Huang and Bing Liu and Farong Ye and Ping Wang}, doi = {10.1002/anie.202580362}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202580362}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Site-selective construction of N-linked glycopeptides through photoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Marine amoebae-inspired salting hydrogels to reconfigure anisotropy for reprogrammable shape morphing. ANGEW, 64(3), e202580361. (www)

  @article{ , archive = {J_ANGEW}, author = {Guorong Gao and Kaiyang Yin and Junyi Han and Yini Hu and Jincui Gu and Junjie Wei and Tao Chen}, doi = {10.1002/anie.202580361}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202580361}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Marine amoebae-inspired salting hydrogels to reconfigure anisotropy for reprogrammable shape morphing}, volume = {64}, year = {2025}, }
• (2025). Shota tsuru. ANGEW, 64(3), e202422819. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202422819}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202422819}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Shota tsuru}, volume = {64}, year = {2025}, }
• (2025). Graeme howe. ANGEW, 64(3), e202422422. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202422422}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202422422}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Graeme howe}, volume = {64}, year = {2025}, }
• (2025). CORRIGENDUM: Correction to “Enzyme-mediated in situ self-assembly promotes in vivo bioorthogonal reaction for pretargeted multimodality imaging”. ANGEW, 64(3), e202422408. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202422408}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202422408}, shortjournal = {Angew. Chem. Int. Edit.}, title = {CORRIGENDUM: Correction to “Enzyme-mediated in situ self-assembly promotes in vivo bioorthogonal reaction for pretargeted multimodality imaging”}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Cleavage of carbodicarbenes with N2O for accessing stable diazoalkenes: Two-fold ligand exchange at a c(0)-atom (Angew. chem. int. ed. 3/2025). ANGEW, 64(3), e202421515. (www)

  @article{ , archive = {J_ANGEW}, author = {Yijie He and Yichong Lyu and David Tymann and Patrick W. Antoni and Max M. Hansmann}, doi = {10.1002/anie.202421515}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202421515}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Cleavage of carbodicarbenes with N2O for accessing stable diazoalkenes: Two-fold ligand exchange at a c(0)-atom (Angew. chem. int. ed. 3/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Gapped and rotated grain boundary revealed in ultra-small au nanoparticles for enhancing electrochemical CO2 reduction (Angew. chem. int. ed. 3/2025). ANGEW, 64(3), e202421507. (www)

  @article{ , archive = {J_ANGEW}, author = {Wenying Wang and Dong Chen and Victor Fung and Shengli Zhuang and Yue Zhou and Chengming Wang and Guoqing Bian and Yan Zhao and Nan Xia and Jin Li and Haiteng Deng and Lingwen Liao and Jun Yang and De-en Jiang and Zhikun Wu}, doi = {10.1002/anie.202421507}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202421507}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Gapped and rotated grain boundary revealed in ultra-small au nanoparticles for enhancing electrochemical CO2 reduction (Angew. chem. int. ed. 3/2025)}, volume = {64}, year = {2025}, }
• (2025). Back cover: Cleavage of the robust Silicon–Fluorine σ-bond allows Silicon–Carbon bond formation: Synthetic strategies toward ortho-silyl aryl phosphonates (Angew. chem. int. ed. 3/2025). ANGEW, 64(3), e202421492. (www)

  @article{ , archive = {J_ANGEW}, author = {Suhyun Ji and Soomin Kim and Jae Kyun Lee and Duck-Hyung Lee and Seo-Jung Han}, doi = {10.1002/anie.202421492}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202421492}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Cleavage of the robust Silicon–Fluorine σ-bond allows Silicon–Carbon bond formation: Synthetic strategies toward ortho-silyl aryl phosphonates (Angew. chem. int. ed. 3/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Proton intercalation into an open-tunnel bronze phase with near-zero volume change (Angew. chem. int. ed. 3/2025). ANGEW, 64(3), e202421490. (www)

  @article{ , archive = {J_ANGEW}, author = {Kosuke Kawai and Seong-Hoon Jang and Yuta Igarashi and Koji Yazawa and Kazuma Gotoh and Jun Kikkawa and Atsuo Yamada and Yoshitaka Tateyama and Masashi Okubo}, doi = {10.1002/anie.202421490}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202421490}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Proton intercalation into an open-tunnel bronze phase with near-zero volume change (Angew. chem. int. ed. 3/2025)}, volume = {64}, year = {2025}, }
• (2025). Single-electron oxidation triggered by visible-light-excited enzymes for asymmetric biocatalysis. ANGEW, 64(3), e202419262. (www)

  @article{ , abstract = {By integrating enzymatic catalysis with photocatalysis, photoenzymatic catalysis emerges as a powerful strategy to enhance enzyme catalytic capabilities and provide superior stereocontrol in reactions involving reactive intermediates. Repurposing naturally occurring enzymes using visible light is among the most active directions of photoenzymatic catalysis. This Minireview focuses on a cutting-edge strategy in this direction, namely single-electron-oxidation-triggered non-natural biotransformations catalyzed by photoexcited enzymes. These straightforward transformations feature a unique radical mechanism initiated by single-electron oxidation, achieving redox-neutral non-natural C−C, C−O, and C−S bond formation, and expanding the chemical toolbox of enzymes. By highlighting recent advances in this field and emphasizing their catalytic mechanisms and synthetic potential, innovative approaches for photobiomanufacturing are anticipated.}, archive = {J_ANGEW}, author = {Jinhai Yu and Bin Chen and Xiaoqiang Huang}, doi = {10.1002/anie.202419262}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202419262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-electron oxidation triggered by visible-light-excited enzymes for asymmetric biocatalysis}, volume = {64}, year = {2025}, }
• (2025). Ether-free alkaline polyelectrolytes for water electrolyzers: Recent advances and perspectives. ANGEW, 64(3), e202418324. (www)

  @article{ , abstract = {Anion exchange membrane (AEM) water electrolyzers (AEMWEs) have attracted great interest for their potential as sustainable, environmentally friendly, low-cost sources of renewable energy. Alkaline polyelectrolytes play a crucial role in AEMWEs, determining their performance and longevity. Because heteroatom-containing polymers have been shown to have poor durability in alkaline conditions, this review focuses on ether-free alkaline polyelectrolytes, which are more chemically stable. The merits, weaknesses, and challenges in preparing ether-free AEMs are summarized and highlighted. The evaluation of synthesis methods for polymers, modification strategies, and cationic stability will provide insights valuable for the structural design of future alkaline polyelectrolytes. Moreover, the in situ degradation mechanisms of AEMs and ionomers during AEMWE operation are revealed. This review provides insights into the design of alkaline polyelectrolytes for AEMWEs to accelerate their widespread commercialization.}, archive = {J_ANGEW}, author = {Chuan Hu and Yong Wang and Young Moo Lee}, doi = {10.1002/anie.202418324}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202418324}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ether-free alkaline polyelectrolytes for water electrolyzers: Recent advances and perspectives}, volume = {64}, year = {2025}, }
• (2025). Organic circularly polarized room-temperature phosphorescence: Strategies, applications and challenges. ANGEW, 64(3), e202417906. (www)

  @article{ , abstract = {Organic circularly polarized luminescence (CPL) plays crucial roles in chemistry and biology for the potential in chiral recognition, asymmetric catalysis, 3D displays, and biological probes. The long-lived luminescence, large Stokes shift, and unique chiroptical properties make organic circularly polarized room-temperature phosphorescence (CPP) a new research hotspot in recent years. Nevertheless, achieving high-performance organic CPP is still challenging due to the sensitivity and complexity of integrating triplet excitons and polarization within organic materials. This review summarizes the latest advances in organic CPP, ranging from design strategies and photophysical properties to underlying luminescence mechanisms and potential applications. Specifically, the design strategies for generating CPP are systemically categorized and discussed according to the interactions between chiral units and chromophores. The applications of organic CPP in organic light-emitting diodes, sensing, chiral recognition, afterglow displays, and information encryption are also illustrated. In addition, we present the current challenges and perspectives on developing organic CPP. We expect this review to provide some instructive design principles to fabricate high-performance organic CPP materials, offering an in-depth understanding of the luminescence mechanism and paving the way toward diverse practical applications.}, archive = {J_ANGEW}, author = {Xin Zou and Nan Gan and Yaru Gao and Long Gu and Wei Huang}, doi = {10.1002/anie.202417906}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202417906}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic circularly polarized room-temperature phosphorescence: Strategies, applications and challenges}, volume = {64}, year = {2025}, }
• (2025). Crystalline assemblies of DNA nanostructures and their functional properties. ANGEW, 64(3), e202416948. (www)

  @article{ , abstract = {Self-assembly presents a remarkable approach for creating intricate structures by positioning nanomaterials in precise locations, with control over molecular interactions. For example, material arrays with interplanar distances similar to the wavelength of light can generate structural color through complex interactions like scattering, diffraction, and interference. Moreover, enzymes, plasmonic nanoparticles, and luminescent materials organized in periodic lattices are envisioned to create functional materials with various applications. Focusing on structural DNA nanotechnology, here, we summarized the recent developments of two- and three-dimensional lattices made purely from DNA nanostructures. We review DNA-based monomer design for different lattices, guest molecule assembly, and inorganic material coating techniques and discuss their functional properties and potential applications in photonic crystals, nanoelectronics, and bioengineering as well as future challenges and perspectives.}, archive = {J_ANGEW}, author = {Xueqiao Li and Jiaoyang Wang and Anna Baptist and Wenna Wu and Amelie Heuer-Jungemann and Tao Zhang}, doi = {10.1002/anie.202416948}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202416948}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystalline assemblies of DNA nanostructures and their functional properties}, volume = {64}, year = {2025}, }
• (2025). Marine amoebae-inspired salting hydrogels to reconfigure anisotropy for reprogrammable shape morphing. ANGEW, 64(3), e202416672. (www)

  @article{ , abstract = {Reprogrammable shape morphing is ubiquitous in living beings and highly crucial for them to move in normal situations, even to survive under dangerous conditions. There is increasing interest in using asymmetric hydrogel structures to understand and mimic living beings’ shape morphing upon an external trigger in a controlled way. However, these asymmetric or heterogeneous configurations cannot be further modified once the polymer hydrogels are prepared. Therefore, it is a great challenge to achieve reprogrammable shape morphing using the existing hydrogels. Inspired by marine amoebae, which transform into several different morphologies according to the various external salt concentrations, a new strategy is developed for salting hydrogels to reconfigure their anisotropy toward reprogrammable shape morphing. Polyampholyte hydrogels with equal stoichiometric COO − and N + (CH 3 ) 3 groups were first swollen in HCl/NaCl solution. After being then transferred into water, they first swollen again by water uptake driven by the osmotic pressure, and then were spontaneously deswollen due to increase in internal pH and dialysis of ions leading to deprotonation of COOH to COO − and regeneration of COO − /N + (CH 3 ) 3 electrostatic attraction. This work provides a novel strategy to reconfigure anisotropy of hydrogel soft actuators and to open up an avenue for reprogrammable shape morphing.}, archive = {J_ANGEW}, author = {Guorong Gao and Kaiyang Yin and Junyi Han and Yini Hu and Jincui Gu and Junjie Wei and Tao Chen}, doi = {10.1002/anie.202416672}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202416672}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Marine amoebae-inspired salting hydrogels to reconfigure anisotropy for reprogrammable shape morphing}, volume = {64}, year = {2025}, }
• (2025). Enabling visible light sensitization of YbIII, NdIII and ErIII in dimeric LnIII/GaIII metallacrowns through functionalization with RuII complexes for NIR-II multiplex imaging. ANGEW, 64(3), e202416101. (www)

  @article{ , abstract = {Multiplex imaging in the second near-infrared window (NIR-II, 1000–1700 nm) provides exciting opportunities for more precise understanding of biological processes and more accurate diagnosis of diseases by enabling real-time acquisition of images with improved contrast and spatial resolution in deeper tissues. Today, the number of imaging agents suitable for this modality remains very scarce. In this work, we have synthesized and fully characterized, including theoretical calculations, a series of dimeric Ln III /Ga III metallacrowns bearing Ru II polypyridyl complexes, LnRu-3 (Ln=Y III , Yb III , Nd III , Er III ). Relaxed structures of YRu-3 in the ground and the excited electronic states have been calculated using dispersion-corrected density functional theory methods. Detailed photophysical studies of LnRu-3 have demonstrated that characteristic emission signals of Yb III , Nd III and Er III in the NIR-II range can be sensitized upon excitation in the visible range through Ru II -centered metal-to-ligand charge transfer (MLCT) states. We have also showed that these NIR-II signals are unambiguously detected in an imaging experiment using capillaries and biological tissue-mimicking phantoms. This work opens unprecedented perspectives for NIR-II multiplex imaging using Ln III -based molecular compounds.}, archive = {J_ANGEW}, author = {Codruţa C. Bădescu-Singureanu and Anton S. Nizovtsev and Vincent L. Pecoraro and Stéphane Petoud and Svetlana V. Eliseeva}, doi = {10.1002/anie.202416101}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202416101}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enabling visible light sensitization of YbIII, NdIII and ErIII in dimeric LnIII/GaIII metallacrowns through functionalization with RuII complexes for NIR-II multiplex imaging}, volume = {64}, year = {2025}, }
• (2025). Nuclear quantum effects have a significant impact on UV/Vis absorption spectra of chromophores in water. ANGEW, 64(3), e202416058. (www)

  @article{ , abstract = {Despite the broadly acknowledged importance of solvation effects on measured UV/Vis spectra in the context of solvatochromism or chemical reactions in solution, it is still an open challenge to calculate UV/Vis spectra with predictive accuracy. This is particularly true when it comes to the impact of nuclear quantum effects on these experimental observables. In the present work, we calculate the UV/Vis absorption spectrum of indole in aqueous solution with a combination of a correlated wavefunction method for computing electronic excitation energies and enhanced path integral simulations for rigorous sampling of nuclear configurations including the quantum effects in solution. After validating our approach based on gas-phase benchmarking, we demonstrate that the lineshape of the spectrum measured in aqueous solution is quantitatively recovered, without the application of any shifting, scaling, or broadening, only after including nuclear quantum effects in addition to thermal fluctuations and solvation at ambient conditions. Our findings demonstrate that nuclear quantum effects are “visible” in UV/Vis spectra of chromophores measured in solution even at room temperature and, therefore, that they must be considered computationally to achieve predictive accuracy.}, archive = {J_ANGEW}, author = {Shota Tsuru and Bikramjit Sharma and Christof Hättig and Dominik Marx}, doi = {10.1002/anie.202416058}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202416058}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nuclear quantum effects have a significant impact on UV/Vis absorption spectra of chromophores in water}, volume = {64}, year = {2025}, }
• (2025). Hollow hydrogels for excellent aerial water collection and autonomous release. ANGEW, 64(3), e202415936. (www)

  @article{ , abstract = {Air moisture is a valuable and omnipresent resource of fresh water. However, traditional water collectors come with an enduring problem of the water-release step, which requires special devices and additional energy to remove the water from the adsorbent, such as heat, sunlight, or both. Herein, we report the first composite conical hollow hydrogel architecture fabricated through a film- to -tube transforming protocol, designed to harvest water from aerial humidity. This hollow hydrogel device can rapidly collect water from humid air to a saturation point, whereupon it automatically and continually releases fresh water at room temperature. The entire water collection and release process does not require any external assistance. Therefore, this device is highly suitable for emergency water collection in arid areas. As an exemplary demonstration, positioning the hollow hydrogel device next to a plant turns into an individualized system for irrigation. Since the device is biodegradable, it eventually decomposes and becomes an organic fertilizer after the water supply is not required. For long-term application, the water-release process can be monitored in real time by an electronic device to indicate the amount of collected water. The hollow hydrogel combines the humidity-adsorbing capacity with autonomous water release that carries the potential for harvesting water from humidity to address the shortage of fresh water, especially in arid locations where other sources of water are scarce or inaccessible.}, archive = {J_ANGEW}, author = {Shumin Liang and Marieh B. Al-Handawi and Tao Chen and Panče Naumov and Lidong Zhang}, doi = {10.1002/anie.202415936}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415936}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hollow hydrogels for excellent aerial water collection and autonomous release}, volume = {64}, year = {2025}, }
• (2025). Pd(II)-catalyzed asymmetric [2+2] annulation for the construction of chiral benzocyclobutenes. ANGEW, 64(3), e202415927. (www)

  @article{ , abstract = {Asymmetric de novo synthesis of benzocyclobutenes (BCBs) via catalytic intermolecular reaction is highly desired for efficient access to this important class of compounds, yet such a strategy remains unmet challenge. Here, we report a Pd/Pyrox-catalyzed asymmetric [2+2] annulation between arylboronic acids and functionalized alkenes, providing an unprecedented efficient protocol to access various enantio-enriched BCBs in a modular and versatile manner under mild conditions. A broad substrate scope with excellent enantioselectivity has been achieved under the current protocol. The isolation and characterization of the key chiral palladacycle intermediate, together with DFT calculations, provides strong evidence for the catalytic pathway including an enantiodetermining arylpalladation step.}, archive = {J_ANGEW}, author = {Pranab K. Pramanick and Shen Zhao and Hao-Tian Ji and Xiangyang Chen and Guoqiang Yang}, doi = {10.1002/anie.202415927}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415927}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pd(II)-catalyzed asymmetric [2+2] annulation for the construction of chiral benzocyclobutenes}, volume = {64}, year = {2025}, }
• (2025). Catalyst-free diborylation and silaboration of azoarenes: A simple photoinduced approach. ANGEW, 64(3), e202415913. (www)

  @article{ , abstract = {The diborylation of the N=N double bond of azoarenes has been achieved using a commercially available diboron reagent, B 2 cat 2 [bis(catecholato)diboron]. By utilizing the photo-switchable nature of azoarenes under blue-LED light irradiation, an uncatalyzed diborylation and silaboration yielded a broad range of functionalized hydrazine derivatives. The mechanistic origin validates the importance of cis configuration, which is corroborated by theoretical calculations.}, archive = {J_ANGEW}, author = {Reetu Rani Mondal and Apurba Kumar Pal and K. Geetharani}, doi = {10.1002/anie.202415913}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalyst-free diborylation and silaboration of azoarenes: A simple photoinduced approach}, volume = {64}, year = {2025}, }
• (2025). Novel amorphous nitride-halide solid electrolytes with enhanced performance for all-solid-state batteries. ANGEW, 64(3), e202415847. (www)

  @article{ , abstract = {Solid electrolytes (SEs) in all-solid-state batteries (ASSBs) are garnering considerable attention for their potential applications in next-generation energy storage systems. Amorphous SEs with dual-anion hold great promise for achieving favorable performance, such as high ionic conductivity and good compatibility with electrodes within ASSBs. Here, we discover a family of amorphous nitride-halide SEs, Li 3 x MCl y N x (M=Ta or La, 1≤3 x ≤1.4, y=5 or 3), which can achieve ionic conductivities up to 7.34 mS cm −1 at 30 °C. The amorphous properties and local structures are investigated using powder X-ray diffraction, cryogenic transmission electron microscopy, and atomic pair distribution function analysis. Impressively, ASSBs employing amorphous Li 3 x TaCl 5 N x have demonstrated good performance at high rates and charging voltages, as well as at low temperature.}, archive = {J_ANGEW}, author = {Bolong Hong and Lei Gao and Pengfei Nan and Yuhang Li and Ming Liu and Ruqiang Zou and Jun Gu and Qiang Xu and Jinlong Zhu and Songbai Han}, doi = {10.1002/anie.202415847}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Novel amorphous nitride-halide solid electrolytes with enhanced performance for all-solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). Catalytic dearomative [1,5]-sigmatropic carbon shift of heterole-fused norcaradienes enabled concise helicenation. ANGEW, 64(3), e202415839. (www)

  @article{ , abstract = {In contrast to the locked fluxionality of norcaradienes fused by benzene, unexplored less aromatic heterole-fused norcaradienes, creatively generated by intramolecular hydroarylation of heteroaryl alkynylcyclopropanes, reserve a balancing fluxionality that permits a dearomative [1,5]-sigmatropic carbon shift of norcaradienes akin to the reduced aromaticity of heterole. This “walk” shift was confirmed by the isolation of a cycloheptatriene species derived from ring-expansion of a dearomatized alkynylated heterole-fused norcaradiene. A following ester-directed ring-opening rearomatization of these dearomatized heterole-fused norcaradienes gives the products featuring migratory acylmethyls that are competent for helicenation with the neighboring (hetero) arenes via (formal) dehydrative alkenylation. Such balancing reactivity of heterole-fused norcaradienes will open up the opportunity for the development of controllable reactions of fused norcaradienes.}, archive = {J_ANGEW}, author = {Hongyan Bi and Chaoren Shen and Sunewang R. Wang}, doi = {10.1002/anie.202415839}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415839}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic dearomative [1,5]-sigmatropic carbon shift of heterole-fused norcaradienes enabled concise helicenation}, volume = {64}, year = {2025}, }
• (2025). Construction of liposome-based extracellular artificial organelles on individual living cells. ANGEW, 64(3), e202415823. (www)

  @article{ , abstract = {Integration of living cells with extrinsic functional entities gives rise to bioaugmented nanobiohybrids, which hold tremendous potential across diverse fields such as cell therapy, biocatalysis, and cell robotics. This study presents a biocompatible method for incorporating multilayered functional liposomes onto the cell surface, creating extracellular artificial organelles or exorganelles. The introduction of various extrinsic functionalities to cells is achieved without comprising their viabilities. The integration of extrinsic enzymatic reactions is exemplified through the cascade reaction involving glucose oxidase and horseradish peroxidase. Furthermore, our protocol offers the design flexibility to customize liposome compositions, thereby providing effective cell modification. The versatility of the liposome-based exorganelle approach establishes an advanced chemical tool, empowering cells with novel functionalities that surpass or are complementary to their innate capabilities.}, archive = {J_ANGEW}, author = {Seoin Yang and Wongu Youn and Hyeong Bin Rheem and Sang Yeong Han and Nayoung Kim and Sol Han and Philipp Schattling and Brigitte Städler and Insung S. Choi}, doi = {10.1002/anie.202415823}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415823}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of liposome-based extracellular artificial organelles on individual living cells}, volume = {64}, year = {2025}, }
• (2025). Assembly regulates gamma radiation polymerization of polytelluoxane. ANGEW, 64(3), e202415811. (www)

  @article{ , abstract = {Regulating chemical drug's responsiveness to gamma radiation is crucial for achieving better therapeutic effects in cancer treatment. Most research focused on thermodynamic chemical structure design, while little attention was paid to kinetic regulate strategy, which possesses greater universality and security. In this study, we achieved a kinetic-based regulate strategy of gamma radiation reaction, through the construction of microphase environment during polymerization of polytelluoxane (PTeO). We designed hydrophobic segments forming large compound micelles (LCMs) assembly to create kinetically favorable higher concentration for radiation-induced reaction. It exhibited a > ten times higher responsiveness and, as far as we know, merely required a minimum dosage of 5 Gy for polymerization to occur. What's more, by taking advantages of the assembly change with Te−O hydrophilic segments and gamma radiation, polymerization became milder with lower polydispersity than previous methods. Such kinetic-based regulate strategy could offer a novel perspective on the design of radiation-responsive chemoradiotherapy and other radiation-induced chemical process.}, archive = {J_ANGEW}, author = {Shenghan Zhang and Yijie Lu and Junjie Song and Jun Guan and Yiheng Dai and Wei Cao and Huaping Xu}, doi = {10.1002/anie.202415811}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415811}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Assembly regulates gamma radiation polymerization of polytelluoxane}, volume = {64}, year = {2025}, }
• (2025). An ultrasound-activated supramolecular modulator enhancing autophagy to prevent ventricular arrhythmias post-myocardial infarction. ANGEW, 64(3), e202415802. (www)

  @article{ , abstract = {Ventricular arrhythmias (VAs) triggered by myocardial infarction (MI) are the leading cause of sudden cardiac mortality worldwide. Current therapeutic strategies for managing MI-induced VAs, such as left stellate ganglion resection and ablation, are suboptimal, highlighting the need to explore safer and more effective intervention strategies. Herein, we rationally designed two supramolecular sonosensitizers RuA and RuB , engineered through acceptor modification to generate moderate reactive oxygen species (ROS) to modulate VAs. Both RuA and RuB demonstrated high ultrasound (US)-activated ROS production efficiency, with singlet oxygen ( 1 O 2 ) quantum yield (Φ Δ ) of 0.70 and 0.88, respectively, surpassing ligand IR1105 and the conventional sonosensitizer ICG (Φ Δ =0.40). In vitro, RuB , at a modest concentration and under US intensity notably boosts pro-survival autophagy in microglia BV2 cell. To improve in vivo stability and biocompatibility, RuB was further encapsulated into DSPE-PEG 5000 to prepare RuB nanoparticles ( RuB NPs). In vivo studies after microinjection of RuB NPs into the paraventricular nucleus (PVN) and subsequent US exposure, demonstrated that RuB NPs-mediated US modulation effectively suppresses sympathetic nervous activity (SNA) and inflammatory responses, thereby preventing VAs. Importantly, no tissue injury was observed post RuB NPs-mediated US modulation. This work pioneers the design of long-wave emission supramolecular sonosensitizers, offering new insights into regulating cardiovascular diseases.}, archive = {J_ANGEW}, author = {Yida Pang and Qian Li and Jiale Wang and Songyun Wang and Amit Sharma and Yuling Xu and Haoyuan Hu and Junrong Li and Shuang Liu and Yao Sun}, doi = {10.1002/anie.202415802}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415802}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An ultrasound-activated supramolecular modulator enhancing autophagy to prevent ventricular arrhythmias post-myocardial infarction}, volume = {64}, year = {2025}, }
• (2025). Building asymmetric Zn−N3 bridge between 2D photocatalyst and co-catalyst for directed charge transfer toward efficient H2O2 synthesis. ANGEW, 64(3), e202415800. (www)

  @article{ , abstract = {Two-dimensional (2D) polymeric semiconductors are a class of promising photocatalysts; however, it remains challenging to facilitate their interlayer charge transfer for suppressed in-plane charge recombination and thus improved quantum efficiency. Although some strategies, such as π–π stacking and van der Waals interaction, have been developed so far, directed interlayer charge transfer still cannot be achieved. Herein, we report a strategy of forming asymmetric Zn−N 3 units that can bridge nitrogen (N)-doped carbon layers with polymeric carbon nitride nanosheets (C 3 N 4 −Zn−N(C)) to address this challenge. The symmetry-breaking Zn−N 3 moiety, which has an asymmetric local charge distribution, enables directed interfacial charge transfer between the C 3 N 4 photocatalyst and the N-doped carbon co-catalyst. As evidenced by femtosecond transient absorption spectroscopy, charge separation can be significantly enhanced by the interfacial asymmetric Zn−N 3 bonding bridges. As a result, the designed C 3 N 4 −Zn−N(C) catalyst exhibits dramatically enhanced H 2 O 2 photosynthesis activity, outperforming most of the reported C 3 N 4 -based catalysts. This work highlights the importance of tailoring interfacial chemical bonding channels in polymeric photocatalysts at the molecular level to achieve effective spatial charge separation.}, archive = {J_ANGEW}, author = {Weikang Wang and Rong Liu and Jianjun Zhang and Tingting Kong and Lele Wang and Xiaohui Yu and Xiaomin Ji and Qinqin Liu and Ran Long and Zhou Lu and Yujie Xiong}, doi = {10.1002/anie.202415800}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415800}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Building asymmetric Zn−N3 bridge between 2D photocatalyst and co-catalyst for directed charge transfer toward efficient H2O2 synthesis}, volume = {64}, year = {2025}, }
• (2025). Creating spin channels in SrCoO3 through trigonal-to-cubic structural transformation for enhanced oxygen Evolution/Reduction reactions. ANGEW, 64(3), e202415797. (www)

  @article{ , abstract = {Oxygen evolution and reduction reactions (OER and ORR) play crucial roles in energy conversion processes such as water splitting and air batteries, where spin dynamics inherently influence their efficiency. However, the specific contribution of spin has yet to be fully understood. In this study, we intentionally introduce a spin channel through the transformation of trigonal antiferromagnetic SrCoO 2.5 into cubic ferromagnetic SrCoO 3 , aiming to deepen our understanding of spin dynamics in catalytic reactions. Based on the results from spherical-aberration-corrected microscopy, synchrotron absorption spectra, magnetic characterizations, and density functional theory calculations, it is revealed that surface electron transfer is predominantly governed by local geometric structures, while the presence of the spin channel significantly enhances the bulk transport of spin-polarized electrons, particularly under high current densities where surface electron transfer is no longer the limiting factor. The overpotential for OER is reduced by at least 70 mV at 150 mA cm −2 due to the enhanced conductivity from spin-polarized electrons facilitated by spin channels, with an expectation of even more significant reductions at higher current densities. This work provides a clearer picture of the role of spin in oxygen-involved electrocatalysis, providing critical insights for the design of more efficient catalytic systems in practical applications.}, archive = {J_ANGEW}, author = {Xinwei Guan and Mingyue Wang and Zezhi Chen and Chaojie Cao and Zhixuan Li and Ruichang Xue and Yang Fu and Bernt Johannessen and Anton Tadich and Jiabao Yi and Hua Fan and Nana Wang and Baohua Jia and Xiaoning Li and Tianyi Ma}, doi = {10.1002/anie.202415797}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415797}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Creating spin channels in SrCoO3 through trigonal-to-cubic structural transformation for enhanced oxygen Evolution/Reduction reactions}, volume = {64}, year = {2025}, }
• (2025). Investigating competing inner- and outer-sphere electron-transfer pathways in copper photoredox-catalyzed atom-transfer radical additions: Closing the cycle. ANGEW, 64(3), e202415792. (www)

  @article{ , abstract = {This integrated computational and experimental study comprehensively examines the viability of competing inner-sphere electron transfer (ISET) and outer-sphere electron transfer (OSET) processes in [Cu(dap) 2 ] + -mediated atom-transfer radical additions (ATRA) of olefins and CF 3 SO 2 Cl that can deliver both R−SO 2 Cl and R−Cl products. Five sterically- and electronically-varied representative alkenes were selected from which to explore and reconcile a range of experimentally observed outcomes. Findings are consistent with photoexcited [Cu(dap) 2 ] + initiating photoelectron transfer via ISET and the subsequent regeneration of the oxidized catalyst via ISET in the ground state to close the catalytic cycle and liberate products. R−SO 2 Cl/R−Cl product ratios appear to be primarily governed by the relative rates of direct catalyst regeneration {i.e., [Cu(dap) 2 SO 2 Cl]⋅ + +R⋅} and ligand exchange {i.e., [Cu(dap) 2 SO 2 Cl]⋅ + +Cl − }. Through this work, a more consistent and more complete conceptual framework has been developed to better understand this chemistry and how catalyst regeneration occurs. It is this important ground state process, which closes the catalytic cycle, and ultimately controls the enantioselectivity of ATRA reactions employing chiral copper photocatalysts.}, archive = {J_ANGEW}, author = {Le Nhan Pham and Angus Olding and Curtis C. Ho and Alex C. Bissember and Michelle L. Coote}, doi = {10.1002/anie.202415792}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415792}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Investigating competing inner- and outer-sphere electron-transfer pathways in copper photoredox-catalyzed atom-transfer radical additions: Closing the cycle}, volume = {64}, year = {2025}, }
• (2025). Planar tetracoordinate silicon in Si3Cu3− cluster. ANGEW, 64(3), e202415789. (www)

  @article{ , abstract = {Photoelectron spectroscopy and theoretical calculations have identified the global minimum structure of the 16-valence electron Si 3 Cu 3 − cluster, which features a planar tetracoordinate silicon (ptSi) in a rhombic arrangement. The Si 3 and Cu 3 triangles are interconnected by a Si 2 /Cu 2 edge, forming an ordered chain-like structure. Besides the conventional 2c–2e σ-bond connecting Si 3 and Cu 3 , the stability of this cluster is reinforced by a delocalized 3c–2e σ-bond in Cu 3 and a π-bond in Si 3 . Our study provides experimental confirmation of a planar hypercoordinate heavier Group 14 element, opening possibilities for exploring similar structures in two-dimensional materials.}, archive = {J_ANGEW}, author = {Xiao-han Yin and Hong-lin Zeng and Xin-bo Liu and Xi-Ling Xu and Hong-Guang Xu and Gabriel Merino and Wei-jun Zheng and Zhong-hua Cui}, doi = {10.1002/anie.202415789}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415789}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Planar tetracoordinate silicon in Si3Cu3− cluster}, volume = {64}, year = {2025}, }
• (2025). Polyoxometalates-mediated selectivity in pt single-atoms on ceria for environmental catalysis. ANGEW, 64(3), e202415786. (www)

  @article{ , abstract = {Optimizing the reactivity and selectivity of single-atom catalysts (SACs) remains a crucial yet challenging issue in heterogeneous catalysis. This study demonstrates selective catalysis facilitated by a polyoxometalates-mediated electronic interaction (PMEI) in a Pt single-atom catalyst supported on CeO 2 modified with Keggin-type phosphotungstate acid (HPW), labeled as Pt 1 /CeO 2 -HPW. The PMEI effect originates from the unique arrangement of isolated Pt atoms and HPW clusters on the CeO 2 support. Electrons are transferred from the ceria support to the electrophilic tungsten in HPW clusters, and subsequently, Pt atoms donate electrons to the now electron-deficient ceria. This phenomenon enhances the positive charge of Pt atoms, moderating O 2 activation and limiting lattice oxygen mobility compared to the conventional Pt 1 /CeO 2 catalyst. The resulting electronic structure of Pt combined with the strong and local acidic environment of HPW on Pt 1 /CeO 2 -HPW leads to improved efficiency and N 2 selectivity in the degradation of NH 3 and NO, as well as increased CO 2 yield when inputting volatile organic compounds. This study sheds the light on the design of SACs with balanced reactivity and selectivity for environmental catalysis.}, archive = {J_ANGEW}, author = {Tianwei Lan and Rambabu Yalavarthi and Yongjie Shen and Min Gao and Fuli Wang and Qingmin Hu and Pengfei Hu and Mohsen Beladi-Mousavi and Xin Chen and Xiaonan Hu and Huiqian Yang and Emiliano Cortés and Dengsong Zhang}, doi = {10.1002/anie.202415786}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyoxometalates-mediated selectivity in pt single-atoms on ceria for environmental catalysis}, volume = {64}, year = {2025}, }
• (2025). Regulating the spin-state of cobalt in three-dimensional covalent organic frameworks for high-performance sodium-iodine rechargeable batteries. ANGEW, 64(3), e202415759. (www)

  @article{ , abstract = {Although the catalytic activity is heavily reliant on the electronic structure of the catalyst, understanding the impact of electron spin regulation on electrocatalytic performance is still rarely investigated. This work presents a novel approach involving the single-atom coordination of cobalt (Co) within metalloporphyrin-based three-dimensional covalent organic frameworks (3D-COFs) to facilitate the catalytic conversion for sodium-iodine batteries. The spin state of Co is modulated by altering the oxidation state of the porphyrin-centered Co, achieving optimal catalysis for iodine reduction. Experimental results demonstrate that Co II and Co III are incorporated into the 3D-COFs, exhibiting spin ground states of S=1/2 and S=0, respectively. The low spin state of Co III is favorable to hybridize with the sp 3d orbitals of I 3 − , thus facilitating the conversion of I 3 − to I − . Density-functional theory (DFT) calculations further reveal that the presence of Co III enhances iodide adsorption and accelerates the formation of NaI in 3D-COFs-Co III , thereby promoting its rapid kinetic behaviors. Notably, the I 2 @3D-COFs-Co III cathode achieves a high reversible capacity of 227.7 mAh g −1 after 200 cycles at 0.5 C and demonstrates exceptional cyclic stability, exceeding 2000 cycles at 10 C with a minor capacity fading rate of less than one 0.01 % per cycle.}, archive = {J_ANGEW}, author = {Chaofei Guo and Tiancun Liu and Zhenzhen Wang and Yu-Xuan Wang and Mfitumucunguzi Steven and Yuhan Luo and Xiping Luo and Yong Wang}, doi = {10.1002/anie.202415759}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415759}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating the spin-state of cobalt in three-dimensional covalent organic frameworks for high-performance sodium-iodine rechargeable batteries}, volume = {64}, year = {2025}, }
• (2025). Ligand-tuning metallic sites in molecular complexes for efficient water oxidation. ANGEW, 64(3), e202415755. (www)

  @article{ , abstract = {Metal-organic hybrid catalysts with highly tunable single-sites are promising for oxygen-evolution reaction (OER), but molecular-scale understanding of underlying reaction mechanisms still remain elusive on these bulk materials. Herein, we report a direct construction of heterogenized molecular complexes stabilized on carbon substrates via coordinating Fe−Ni sites with four aromatic carboxylate ligands (FeNi-L x ). The ligands-tuning π-π stacking interaction between aromatic carboxylate ligands and carbon supports promote the oxidative charge accumulation on Fe−Ni sites via fast electron transferring, thus the optimized FeNi-L x rendering a mass activity of 6680 A g Fe/Ni −1 at 0.3 V overpotential. In situ characteristics and theoretical analysis demonstrate that the OH − nucleophilic attack on hypervalent iron sites induce the reconstruction of active Fe−O−Ni species, accompanying with fast valence increasing. Whereas, during OER, the unexpected valence reduction of Fe−O−Ni sites would be attributed to the oxygen-generating from OOH* intermediates. These findings would establish an essential understanding of the origin of active centers in molecular complexes catalysts for oxygen-evolution.}, archive = {J_ANGEW}, author = {Yun Gao and Chengdong Yang and Fenglei Sun and Daping He and Xinqiang Wang and Jian Chen and Xiaobo Zheng and Runcong Liu and Hongge Pan and Dingsheng Wang}, doi = {10.1002/anie.202415755}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415755}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-tuning metallic sites in molecular complexes for efficient water oxidation}, volume = {64}, year = {2025}, }
• (2025). Stable mono-radical and triplet diradicals based on allylic radical-embedded all-benzenoid polycyclic hydrocarbons. ANGEW, 64(3), e202415746. (www)

  @article{ , abstract = {High-spin organic radicals are notable for their unique optical, electronic, and magnetic properties, but synthesizing stable high-spin systems is challenging due to their inherent reactivity. This study presents a novel strategy for designing stable high-spin polycyclic hydrocarbons (PHs) by incorporating allylic radical into fused aromatic benzenoid rings. To enhance stability, large steric hindrance groups with a synergistic captodative effect were added to the allylic radical centers. This approach was applied to synthesize derivatives of two open-shell all-benzenoid PHs: benzo[ fg ]tetracene ( 1 ) and dibenzo[ fg , lm ]heptacene ( 2 ). Both compounds exhibited excellent stability, with diradical 2 showing a half-life of up to 17.2 days under ambient conditions. Bond length analysis and theoretical calculations suggest that 1 and 2 predominantly feature Clar's aromatic sextet structures with embedded allylic radicals. Compound 2 was confirmed to have a triplet ground state through DFT calculations and experimental methods, including pulse EPR spectroscopy and SQUID measurements. This work introduces a new design strategy for stable high-spin hydrocarbons, paving the way for future developments in high-spin organic materials.}, archive = {J_ANGEW}, author = {Lei Wang and Weiwei Niu and Di Tian and Tianyu Jiao and Lemin Zhang and Xudong Hou and Yi Han and Ya Zou and Jishan Wu and Guangwu Li}, doi = {10.1002/anie.202415746}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stable mono-radical and triplet diradicals based on allylic radical-embedded all-benzenoid polycyclic hydrocarbons}, volume = {64}, year = {2025}, }
• (2025). Unlocking self-antioxidant capability and processability of additive-free MXene ink towards high-performance customizable supercapacitors. ANGEW, 64(3), e202415742. (www)

  @article{ , abstract = {The solution processing of MXene ink is the feasible strategy to realize its state-of-the-art applications. Nevertheless, achieving high stability and processability of additive-free MXene ink is particularly challenging. Herein, we propose an oxyanion-terminated Ti 3 C 2 T x MXene ink that exhibits excellent self-antioxidant capability and processability. The vertex-connected polyhedrons of oxyanions capping on the Ti 3 C 2 host serve as an in situ antioxidative shield, effectively preventing the attack of free H 2 O molecules while increasing the robustness of the Ti−C bond and reducing the susceptibility of surface Ti atoms to oxidation. Consequently, the shelf life of MXene ink can be extended up to 5 months at room temperature. Moreover, the high electron accumulation of oxyanions enhances the interlayer interactions among MXene sheets through electrostatic binding, which enables the formation of stable and uniform MXene inks with controlled rheological properties and processability. Inspired by Chinese calligraphy, we utilize the oxyanion-terminated MXene ink to fabricate high-performance and customizable paper supercapacitors, which exhibit exceptional flexibility and stability, allowing them to be tailored to desired capacity, stretchability, and shapes. This in situ surface chemistry strategy of oxyanions can activate the self-antioxidant capability and solution processability of MXene, paving the way for its widespread applications in flexible and wearable electronics.}, archive = {J_ANGEW}, author = {Yuanchuan Zheng and Yalei Wang and Dongqi Liu and Jiupeng Zhao and Yao Li}, doi = {10.1002/anie.202415742}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415742}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking self-antioxidant capability and processability of additive-free MXene ink towards high-performance customizable supercapacitors}, volume = {64}, year = {2025}, }
• (2025). A membrane-anchoring self-assembling peptide allows bioorthogonal coupling of type-I AIEgens for pyroptosis-induced cancer therapy. ANGEW, 64(3), e202415735. (www)

  @article{ , abstract = {Enrichment of photosensitizers (PSs) on cancer cell membranes via bioorthogonal reactions is considered to be a very promising therapeutic modality. However, azide-modified sugars-based metabolic labeling processes usually lack targeting and the labeling speed is relatively slow. Moreover, it has been rarely reported that membrane-anchoring pure type-I PSs can induce cancer cell pyroptosis. Here, we report an alkaline phosphatase (ALP) and cholecystokinin-2 receptor (CCK2R) dual-targeting peptide named DBCO-pYCCK6, which can selectively and rapidly self-assemble on cancer cell membrane, and then bioorthogonal enrich type-I aggregation-induced emission luminogens (AIEgen) PSs (SAIE-N 3 ) on the cell membrane. Upon light irradiation, the membrane-anchoring SAIE-N 3 could effectively generate type-I reactive oxygen species (ROS) to induce gasdermin E (GSDME)-mediated pyroptosis. In vivo experiments demonstrated that the bioorthogonal combination strategy of peptide and AIEgen PSs could significantly inhibit tumor growth, which is accompanied by CD8 + cytotoxic T cell infiltration. This work provides a novel self-assembly peptide-mediated bioorthogonal reaction strategy to bridge the supramolecular self-assembly and AIE field through strain-promoted azide-alkyne cycloaddition (SPAAC) and elucidates that pure type-I membrane-anchoring PSs can be used for cancer therapy via GSDME-mediated pyroptosis.}, archive = {J_ANGEW}, author = {Shenglu Ji and Tengwu Pan and Kaiyuan Wang and Weiqi Zai and Ruikang Jia and Nannan Wang and Shaorui Jia and Dan Ding and Yang Shi}, doi = {10.1002/anie.202415735}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415735}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A membrane-anchoring self-assembling peptide allows bioorthogonal coupling of type-I AIEgens for pyroptosis-induced cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Static organic p-n junctions in photoelectrodes for solar ammonia production with 86 % internal quantum efficiency. ANGEW, 64(3), e202415729. (www)

  @article{ , abstract = {For photoelectrocatalytic cells, a limitation exists in finding appropriate photoelectrode configurations that couple efficient extraction of high-energy electrons from absorbed photons and selective catalysis. Here we report an organic p-n junction approach to fabricate molecular photoelectrodes for conversion of solar energy and nitrate into valuable ammonia product. Solar irradiation of the photoelectrode generates charge-separated states with electrons and holes spatially separated at the n-type and p-type components, as revealed by surface photovoltage mapping, at a quantum yield of 90 %. The high-flux photogenerated electrons are rapidly transferred to the catalyst for solar ammonia production from nitrate reduction at an external quantum efficiency (EQE) and an internal quantum efficiency (IQE) of 57 % and 86 %, respectively. Time-resolved spectroscopic studies reveal that the large IQE originates from the combined high efficiencies for photoelectron generation, catalyst activation and dark catalysis. In a flow-cell setup coupled with a silicon solar cell, the photoelectrode without bias generates photocurrent of 57 mA cm −2 and ammonia at an EQE of 52 %.}, archive = {J_ANGEW}, author = {Yanjie Fang and Mengjie Li and Yifan Gao and Yingke Wen and Bing Shan}, doi = {10.1002/anie.202415729}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415729}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Static organic p-n junctions in photoelectrodes for solar ammonia production with 86 % internal quantum efficiency}, volume = {64}, year = {2025}, }
• (2025). D-electrons of platinum alloy steering CO pathway for low-charge potential li-CO2 batteries. ANGEW, 64(3), e202415728. (www)

  @article{ , abstract = {Aprotic Li-CO 2 batteries suffer from sluggish solid-solid co-oxidation kinetics of C and Li 2 CO 3 , requiring extremely high charging potentials and leading to serious side reactions and poor energy efficiency. Herein, we introduce a novel approach to address these challenges by modulating the reaction pathway with tailored Pt d -electrons and develop an aprotic Li-CO 2 battery with CO and Li 2 CO 3 as the main discharge products. Note that the gas-solid co-oxidation reaction between CO and Li 2 CO 3 is both kinetically and thermodynamically more favorable. Consequently, the Li-CO 2 batteries with CoPt alloy-supported on nitrogen-doped carbon nanofiber (CoPt@NCNF) cathode exhibit a charging potential of 2.89 V at 50 μA cm −2 , which is the lowest charging potential to date. Moreover, the CoPt@NCNF cathode also shows exceptional cycling stability (218 cycles at 50 μA cm −2 ) and high energy efficiency up to 74.6 %. Comprehensive experiments and theoretical calculations reveal that the lowered d -band center of CoPt alloy effectively promotes CO desorption and inhibits further CO reduction to C. This work provides promising insights into developing efficient and CO-selective Li-CO 2 batteries.}, archive = {J_ANGEW}, author = {Limin Liu and Shenyu Shen and Jiatian Li and Ning Zhao and Xiangkai Yin and Hongyang Zhao and Wei Yu and Yaqiong Su and Bao Yu Xia and Shujiang Ding}, doi = {10.1002/anie.202415728}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415728}, shortjournal = {Angew. Chem. Int. Edit.}, title = {D-electrons of platinum alloy steering CO pathway for low-charge potential li-CO2 batteries}, volume = {64}, year = {2025}, }
• (2025). Coordination-driven crosslinking electrolytes for fast lithium-ion conduction and solid-state battery applications. ANGEW, 64(3), e202415727. (www)

  @article{ , abstract = {Rechargeable batteries paired with lithium (Li) metal anodes are considered to be promising high-energy storage systems. However, the use of highly reactive Li metal and the formation of Li dendrites during battery operation would cause safety concerns, especially with the employment of highly flammable liquid electrolytes. Herein, a general strategy by engineering coordination-driven crosslinking networks is proposed to achieve high-performance solid polymer electrolytes. Through the coordination of metal-organic polyhedra (MOPs) with cellulose-based copolymers, the Li + -conducted hypercrosslinked MOP (CHMOP-Li) polymer network is capable of enabling the rapid transport of Li + . In addition to the high Li + conductivity (1.02×10 −3 S cm −1 at 25 °C), CHMOP-Li electrolyte also exhibits a high Li + transference number (0.75) and a wide electrochemical stability window. Benefiting from the thermally stable and mechanically strong CHMOP-Li electrolyte film, the short-circuiting of the symmetric batteries is prevented even after 3200 h of cycling and a high specific energy of 300 Wh kg −1 is achieved for the Li-metal battery. The solid-state Li−O 2 batteries fabricated with CHMOP-Li electrolyte also show good cycling performance (500 cycles) and high discharge capacity (15740 mAh g −1 ). The proposed coordination-driven crosslinking strategies offer an alternative route to design high-performance next-generation sustainable battery chemistries.}, archive = {J_ANGEW}, author = {Xiao-Xue Wang and De-Hui Guan and Xin-Yue Ma and Xin-Yuan Yuan and Qing-Yao Zhu and Hao-Tian Deng and Huan-Feng Wang and Ji-Jing Xu}, doi = {10.1002/anie.202415727}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415727}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coordination-driven crosslinking electrolytes for fast lithium-ion conduction and solid-state battery applications}, volume = {64}, year = {2025}, }
• (2025). Integrated “Two-in-one” strategy for high-rate electrocatalytic CO2 reduction to formate. ANGEW, 64(3), e202415726. (www)

  @article{ , abstract = {The electrochemical CO 2 reduction reaction (ECR) is a promising pathway to producing valuable chemicals and fuels. Despite extensive studies reported, improving CO 2 adsorption for local CO 2 enrichment or water dissociation to generate sufficient H* is still not enough to achieve industrial-relevant current densities. Herein, we report a “two-in-one” catalyst, defective Bi nanosheets modified by CrO x (Bi−CrO x ), to simultaneously promote CO 2 adsorption and water dissociation, thereby enhancing the activity and selectivity of ECR to formate. The Bi−CrO x exhibits an excellent Faradaic efficiency (≈100 %) in a wide potential range from −0.4 to −0.9 V. In addition, it achieves a remarkable formate partial current density of 687 mA cm −2 at a moderate potential of −0.9 V without iR compensation, the highest value at −0.9 V reported so far. Control experiments and theoretical simulations revealed that the defective Bi facilitates CO 2 adsorption/activation while the CrO x accounts for enhancing the protonation process via accelerating H 2 O dissociation. This work presents a pathway to boosting formate production through tuning CO 2 and H 2 O species at the same time.}, archive = {J_ANGEW}, author = {Peng-Xia Lei and Shao-Qing Liu and Qi-Rui Wen and Jia-Yi Wu and Shuwen Wu and Xiaoxiao Wei and Renfei Feng and Xian-Zhu Fu and Jing-Li Luo}, doi = {10.1002/anie.202415726}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415726}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated “Two-in-one” strategy for high-rate electrocatalytic CO2 reduction to formate}, volume = {64}, year = {2025}, }
• (2025). Enantioselective electrocatalysis for cross-dehydrogenative heteroarylation with indoles, pyrroles, and furans. ANGEW, 64(3), e202415723. (www)

  @article{ , abstract = {Oxidative cross-dehydrogenative C−H/C−H functionalizations represent an exemplary approach for synthesizing carbonyl compounds via α-heteroarylation. Here we present the development of a direct anodic oxidative coupling process between 2-acylimidazoles and divergent heterocyclic systems including indole, pyrrole, and furan, facilitated by ferrocene-assisted asymmetric nickel electrocatalysis with high levels of enantioselectivity. Mechanistic investigations indicate that the reaction initially involves the formation of a chiral Ni-bound α-carbonyl radical, which is then captured by the heteroarene radical cation via intermolecular stereoselective radical/radical cation coupling. The mild, scalable, and robust reaction conditions allow for a broad substrate scope and excellent functional group tolerance, enabling access to a wide range of chiral hetero-compounds. The consequential α-heteroaromatic carbonyl products can potentially be transformed into a plethora of synthetically valuable frameworks, as exemplified by their application in the asymmetric total synthesis of (−)-COX-2 inhibitor, (+)-acremoauxin A, and (+)-pemedolac.}, archive = {J_ANGEW}, author = {Kang Liang and Ning Li and Minghao Liu and Jin Song and Chang Guo}, doi = {10.1002/anie.202415723}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415723}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective electrocatalysis for cross-dehydrogenative heteroarylation with indoles, pyrroles, and furans}, volume = {64}, year = {2025}, }
• (2025). C(sp3)−F bond activation by lewis base-boryl radicals via concerted electron-fluoride transfer. ANGEW, 64(3), e202415715. (www)

  @article{ , abstract = {Selective C−F bond activation through a radical pathway in the presence of multiple C−H bonds remains a formidable challenge, owing to the extraordinarily strong bond strength of the C−F bond. By the aid of density functional theory calculations, we disclose an innovative concerted electron-fluoride transfer mechanism, harnessing the unique reactivity of Lewis base-boryl radicals to selectively activate the resilient C−F bonds in fluoroalkanes. This enables the direct abstraction of a fluorine atom and subsequent generation of an alkyl radical, thus expanding the boundaries of halogen atom transfer reactions.}, archive = {J_ANGEW}, author = {Xueying Guo and Yuchen Zhang and Xiaoyu Lai and Yubing Pang and Xiao-Song Xue}, doi = {10.1002/anie.202415715}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415715}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C(sp3)−F bond activation by lewis base-boryl radicals via concerted electron-fluoride transfer}, volume = {64}, year = {2025}, }
• (2025). Single-step synthesis of an ideal chain antiferromagnet [H2(4,4′-bipyridyl)](H3O)2Fe2F10 with spin s=5/2. ANGEW, 64(3), e202415700. (www)

  @article{ , abstract = {One-dimensional (1D) magnets are of great interest owing to their intriguing quantum phenomena and potential application in quantum computing. We successfully synthesized an ideal antiferromagnetic spin S =5/2 chain compound [H 2 (4,4′-bpy)](H 3 O) 2 Fe 2 F 10 (4,4′-bpy=4,4′-bipyridyl) 1 , using a single-step low-temperature hydrothermal method under conditions that favors the protonation of the bulky bidentate ligand 4,4′-bpy. Compound 1 consists of well-separated (Fe 3+ −F−) ∞ chains with a large Fe−F−Fe angle of 174.8°. Both magnetic susceptibility and specific heat measurements show that 1 does not undergo a magnetic long-range ordering down to 0.5 K, despite the strong Fe−F−Fe intrachain spin exchange J with J / k B =−16.2(1) K. This indicates a negligibly weak interchain spin exchange J ′. The J ′/ J value estimated for 1 is extremely small (<2.8×10 −6 ), smaller than those reported for all other S =5/2 chain magnets. Our hydrothermal synthesis incorporates both [H 2 (4,4′-bpy)] 2+ and (H 3 O) + cations into the crystal lattice with numerous hydrogen bonds, hence effectively separating the (Fe 3+ −F−) ∞ spin chains. This single-step hydrothermal synthesis under conditions favoring the protonation of bulky bidentate ligands offers an effective synthetic strategy to prepare well-separated 1D spin chain systems of magnetic ions with various spin values.}, archive = {J_ANGEW}, author = {Yanhong Wang and Yaling Dou and Hiroshi Takastu and Tao Wang and Hyun-Joo Koo and Myung-Hwan Whangbo and Hiroshi Kageyama and Hongcheng Lu}, doi = {10.1002/anie.202415700}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415700}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-step synthesis of an ideal chain antiferromagnet [H2(4,4′-bipyridyl)](H3O)2Fe2F10 with spin s=5/2}, volume = {64}, year = {2025}, }
• (2025). Meso/Microporous single-atom catalysts featuring curved Fe−N4 sites boost the oxygen reduction reaction activity. ANGEW, 64(3), e202415691. (www)

  @article{ , abstract = {Zeolitic-imidazolate frameworks (ZIFs) are among the most efficient precursors for the synthesis of atomically dispersed Fe−N/C materials, which are promising catalysts for enhancing the performance of Zn-air batteries (ZABs) and proton exchange fuel cells (PEMFCs). However, existing ZIF-derived Fe−N/C electrocatalysts mostly consist of microporous materials, leading to insufficient mass transport and inadequate battery/cell performance. In this study, we synthesize an atomically dispersed meso/microporous Fe−N/C material with curved Fe−N 4 active sites, denoted as FeSA−N/TC, through the pyrolysis of hemin-modified ZIF films on ZnO nanorods, obtained from the self-assembly reaction between Zn 2+ from ZnO hydrolysis and 2-methylimidazole. Density functional theory calculations demonstrate that the curved Fe−N 4 active sites can weaken the intermediate adsorptions, resulting in lower free energy barriers and enhanced performance during oxygen reduction reaction (ORR). Specifically, FeSA−N/TC exhibits exceptional ORR performance with half-wave potentials of 0.925 V in alkaline media and 0.825 V in acidic media. When used as the cathodic catalyst in PEMFCs and ZABs, FeSA−N/TC achieves high peak power densities (H 2 −O 2 PEMFC: 1100 mW cm −2 ; H 2 −Air PEMFC: 715 mW cm −2 ; liquid-state ZAB: 228 mW cm −2 ; solid-state ZAB: 112 mW cm −2 ), demonstrating its feasibility and efficiency in practical applications.}, archive = {J_ANGEW}, author = {Ying Yu and Yian Wang and Fei Yang and Dong Feng and Mingyang Yang and Peng-Fei Xie and Yuanzhi Zhu and Minhua Shao and Yi Mei and Jin-Cheng Li}, doi = {10.1002/anie.202415691}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415691}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Meso/Microporous single-atom catalysts featuring curved Fe−N4 sites boost the oxygen reduction reaction activity}, volume = {64}, year = {2025}, }
• (2025). Upcycling iron oxide scale slag into a high-performance, sustainable ozone catalyst. ANGEW, 64(3), e202415689. (www)

  @article{ , abstract = {Upcycling iron slag into a monolithic catalyst has led to low-cost heterogeneous catalytic ozonation (HCO) strategies for water treatment. The primary industrial challenges are the low chemical oxygen demand (COD) reduction rate in treating authentic wastewater and difficulties sustaining close-loop reaction cycles. In this study, we present a monolithic catalyst transformed from low-cost iron oxide scale slag (IOS M ) for highly efficient, sustainable ozone catalysis. The IOS M , constituted of 59.70 % Fe 2 O 3 and 40.30 % Fe 3 O 4 , effectively decomposes ozone into superoxide radicals (⋅O 2 − ) through a close-loop cyclic reaction facilitated by interfacial charge transfer. This mechanism enables super-fast degradation of 100 mg L −1 tetracycline at ozone concentrations below 1.00 mg L −1 in just four minutes, with the iron leaching merely at 59 μg L −1 after 10 cycles. In tests with authentic antibiotic wastewater, the IOS M -based HCO system achieves a record-breaking 81.70 % COD reduction within two hours. This research underscores the potential of upcycling industrial waste into highly effective ozone catalysts for sustainable practices in wastewater treatment.}, archive = {J_ANGEW}, author = {Qing Du and Yanfen Fang and Xing Lan and Cheng Gu and Di Huang and Zhou Shen and Zhi Zhu and Chuncheng Chen and Yan Yan}, doi = {10.1002/anie.202415689}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415689}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Upcycling iron oxide scale slag into a high-performance, sustainable ozone catalyst}, volume = {64}, year = {2025}, }
• (2025). A structural and functional mimic of p680+. ANGEW, 64(3), e202415688. (www)

  @article{ , abstract = {One or multiple chlorophyll a molecules are employed in the reaction center of photosystem II′s main electron donor (defined as P680). We have a poor understanding of how the reaction center facilitates water oxidation in photosystem II and the roles that mono- and/or multimeric chlorophyll groups play when P680 oxidizes a neighboring tyrosine in order to drive water oxidation at the oxygen evolving complex. We have prepared a dimeric Mg II -porphyrin complex [Mg 2 (BTPP)] ( 1 , H 4 -BTPP=1,2-bis-(10,15,20-triphenylporphyrin-5-yl)-benzene) as a structural and functional mimic of the dimeric core of P680. 1 was oxidized by one-electron to the corresponding π-cation radical complex 2 . The radical cation was characterized by UV/Vis-NIR, FT-IR, and EPR spectroscopic techniques. 2 was shown to be reactive towards phenols to give the corresponding phenoxyl radicals, mimicking the reactivity of the P680 cation radical which oxidizes tyrosine to tyrosyl radical. Critically, the dimeric π-cation radical showed markedly higher rates of proton coupled electron transfer oxidation (PCET) of phenols when compared to its monomeric counterpart [Mg(TPP)] (TPP=5,10,15,20-tetraphenylporphyrin). Our findings demonstrate that Mg II -porphyrin complexes are reliable mimics of photosynthetic PCET processes and suggest that photosynthetic reaction centers with multiple π-conjugated complexes likely lower the barrier to PCET oxidation by π-cation radical species.}, archive = {J_ANGEW}, author = {Sachidulal Biswas and Oscar Reid Kelly and Brendan Twamley and Aidan R. McDonald}, doi = {10.1002/anie.202415688}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415688}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A structural and functional mimic of p680+}, volume = {64}, year = {2025}, }
• (2025). Expanding the landscape of phosphorous-based open shell species: Stable mono-, di-, and trianionic radicals based on a contorted triphosphaalkene. ANGEW, 64(3), e202415684. (www)

  @article{ , abstract = {The stepwise reduction of the highly contorted truxene-based triphosphaalkene 1 using KC 8 led to the isolation of mono-, di-, and tri-anionic species. The solid-state molecular structures of mono- and diradical anionic species were elucidated by single crystal X-ray diffractions, revealing elongated P−C bonds and a pronounced “indene” aromatization compared to the parent system. All three radical species displayed distinct Electron Paramagnetic Resonance (EPR) spectra, providing compelling evidence for the open-shell electronic configuration of both the diradical and triradical species—an observation unprecedented in any previously reported phosphorous-based anionic polyradicals. Mulliken spin density calculations revealed a dominant localization of radical spin on a single phosphorous atom in the monoanion. In the dianion, spin localization is observed on two phosphorous atoms (~34 % each), with a minor contribution from the third phosphorous (0.13 %), while the trianion demonstrates a uniform distribution of spin density (~30 %) across each phosphorous atom.}, archive = {J_ANGEW}, author = {Mohd Asif Ansari and Rajesh Deka and Anders Thapper and Andreas Orthaber}, doi = {10.1002/anie.202415684}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415684}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Expanding the landscape of phosphorous-based open shell species: Stable mono-, di-, and trianionic radicals based on a contorted triphosphaalkene}, volume = {64}, year = {2025}, }
• (2025). Dual-stage reduction strategy of tin perovskite enables high performance photovoltaics. ANGEW, 64(3), e202415681. (www)

  @article{ , abstract = {The rapid oxidation of Sn 2+ in tin-based perovskite solar cells (TPSCs) restricts their efficiency and stability have been main bottleneck towards further development. This study developed a novel strategy which utilizes thiosulfate ions (S 2 O 3 2− ) in the precursor solution to enable a dual-stage reduction process. In the solution stage, thiosulfate acted as an efficacious reducing agent to reduce Sn 4+ to Sn 2+ , meanwhile, its oxidation products were able to reduce I 2 to I − during the film stage. This dual reduction ability effectively inhibited the oxidation of Sn 2+ and passivated defects, further promising an excellent stability of the perovskite devices. As a result, thiosulfate-incorporated devices achieved a high efficiency of 14.78 % with open-circuit voltage reaching 0.96 V. The stability of the optimized devices achieved a remarkable improvement, maintaining 90 % of their initial efficiencies after 628 hours at maximum-power-point (MPP). The findings provid research insights and experimental data support for the sustained dynamic reduction in TPSCs.}, archive = {J_ANGEW}, author = {Yu-Tong Yang and Fan Hu and Tian-Yu Teng and Chun-Hao Chen and Jing Chen and Namatullah Nizamani and Kai-Li Wang and Yu Xia and Lei Huang and Zhao-Kui Wang}, doi = {10.1002/anie.202415681}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415681}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-stage reduction strategy of tin perovskite enables high performance photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Conformational modulation of efficient macrocyclic emitters featuring delayed fluorescence by conjugation length and cavity dimensions. ANGEW, 64(3), e202415680. (www)

  @article{ , abstract = {The π-conjugated macrocyclic emitters with thermally activated delayed fluorescence (TADF) characteristics have attracted widespread attention in the field of organic electroluminescence (EL) materials due to their unique geometries and excellent luminescence performance. Despite the significant impact of conjugation length and cavity dimensions on molecular conformation, the influence of these factors on the excited-state properties remains understudied. Herein, we formulated a strategy aimed at modulating the conformation of TADF macrocyclic molecules containing aniline as the donor (D) unit, and triazine as the acceptor (A), linked in D−A and D-π-A alternative macrocyclic construction ( MC-TNT and MC-TST ). Corroborated by experimental and theoretical analyses, the compact and conformationally twisted MC-TNT exhibits efficient blue luminescence in crystalline state, facilitating EL at high doping concentrations with maximum external quantum efficiency (EQE max ) of 13.9 %, leading the field of blue macrocyclic emitters. Notably, MC-TST with π-bridge and flat conformation, demonstrates diminished Coulombic repulsion, achieving nearly 100 % photoluminescence quantum yield and superior horizontal dipole orientation of 85 % in 5 wt % doped films, and the corresponding device‘s EQE max reaches record-high 32.7 % within the TADF macrocyclic domain.}, archive = {J_ANGEW}, author = {Jingping Xiao and Denghui Liu and Yu Fu and Weijia Xie and Yingxiao Mu and Jia-Xiong Chen and Zecong Ye and Shaomin Ji and Yanping Huo and Shi-Jian Su}, doi = {10.1002/anie.202415680}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformational modulation of efficient macrocyclic emitters featuring delayed fluorescence by conjugation length and cavity dimensions}, volume = {64}, year = {2025}, }
• (2025). Nanocarriers made of natural fatty acids: Modulation of their release profiles through photo-crosslinking. ANGEW, 64(3), e202415671. (www)

  @article{ , abstract = {Natural fatty acids are attractive carrier materials for drug delivery, but their rapid dissolution and degradation in vivo calls for new strategies to enhance their stability. Here we report a simple and versatile method capable of photo-crosslinking carriers made of natural fatty acids for drug delivery under controlled release. By optimizing the crosslinking density, the nanoscale carriers show a high drug loading efficiency, together with a stable network structure for minimal degradation in a body fluid mimic. Fluorescence microscopy analysis also reveals the exceptional intracellular stability of the crosslinked network, resulting in negligible cytotoxicity toward A549 cells up to 24 h when loaded with a potent anticancer drug. We further extend this strategy to microscale carriers fabricated using electrospray. Upon photo-crosslinking, the carriers show a retarded release of nerve growth factor, resulting in slower neurite outgrowth from dorsal root ganglion. This work holds promise for addressing the efficacy and safety issues critical to nanomedicine and related applications.}, archive = {J_ANGEW}, author = {Dong Zhang and Yuxuan Meng and Min Hao and Younan Xia}, doi = {10.1002/anie.202415671}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415671}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanocarriers made of natural fatty acids: Modulation of their release profiles through photo-crosslinking}, volume = {64}, year = {2025}, }
• (2025). Three-dimensional (3D) fluoride molecular glue to improve the SnO2/Perovskite interface for efficient perovskite solar cells. ANGEW, 64(3), e202415669. (www)

  @article{ , abstract = {Aiming at numerous defects at SnO 2 /perovskite interface and lattice mismatch in perovskite solar cells (PSCs), we design a kind of three-dimensional (3D) molecular glue (KBF 4 -TFMSA), which is derived from strong intramolecular hydrogen bonding interaction between potassium tetrafluoroborate (KBF 4 ) and trifluoromethane-sulfonamide (TFMSA). A remarkable efficiency of 25.8 % with negligible hysteresis and a stabilized power output of 25.0 % have been achieved, in addition, 24.57 % certified efficiency of 1 cm 2 device is also obtained. Further investigation reveals that this KBF 4 -TFMSA can interact with oxygen vacancies and under-coordinated Sn(IV) from the SnO 2 , in the meantime, FA + (NH 2 −C=NH 2 + ) and K + cations can be well fixed by hydrogen bonding interaction between FA + and BF 4 − , and electrostatic attraction between sulfonyl oxygen and K + ions, respectively. Thereby, FAPbI 3 crystal grain sizes are increased, interfacial defects are significantly reduced while carrier extraction/ transportation is facilitated, leading to better cell performance and excellent stabilities. Non-encapsulated devices can maintain 91 % of their initial efficiency under maximum-power-point (MPP) tracking while continuous illumination (~100 mW cm −2 ) for 1000 h, and retain 91 % of the initial efficiency after 1000 h “double 60” damp-heat stability testing (60 °C and 60 %RH (RH, relatively humidity)).}, archive = {J_ANGEW}, author = {Zijing Chen and Shiyu Jiang and Xiangjin Du and Yiming Li and Jiangjian Shi and Fubo Tian and Huijue Wu and Yanhong Luo and Dongmei Li and Qingbo Meng}, doi = {10.1002/anie.202415669}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three-dimensional (3D) fluoride molecular glue to improve the SnO2/Perovskite interface for efficient perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Calcium carbonate as an ionic molecular lock for ultrastrong fluorescence of single organic molecules. ANGEW, 64(3), e202415664. (www)

  @article{ , abstract = {Locking molecular conformation are widely applied in molecular engineering for improved performance. However, locking via organic functional groups often changes the original molecular properties. Following the rigidity and stability of ionic interaction in ionic compounds, we suggested the use of a molecular-scale ionic compound, calcium carbonate oligomer, as a robust molecular segment to functionalize organic molecules. The rigid structure of the ionic molecular segments locked the organic molecules, which could remarkably limit the intramolecular motion and intermolecular interactions. This ensured a stable and ultrastrong fluorescence of the single organic molecule while preserving its original maximum emission wavelength. The locking strategy was general and extendable to multiple organic molecules. Additionally, the ultrastrong single-molecular fluorescence can be maintained in inorganic solids with even higher quantum yields and almost unchanged maximum emission wavelength. The highest quantum yield of the investigated molecules reached 99.9 %, superior to all reported organic-inorganic fluorescent composite under air conditions. This work demonstrates a general strategy to restrict intramolecular motion and intermolecular interactions by using ionic oligomers as molecular locks, providing an alternative method for realizing ultraemissive molecules. This further demonstrates a fascinating example of molecular engineering in the presence of inorganic ionic molecules.}, archive = {J_ANGEW}, author = {Jian Zhang and Hengyue Xu and Weifeng Fang and Xin Liu and Haoke Zhang and Ruikang Tang and Zhaoming Liu}, doi = {10.1002/anie.202415664}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415664}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Calcium carbonate as an ionic molecular lock for ultrastrong fluorescence of single organic molecules}, volume = {64}, year = {2025}, }
• (2025). Bright nanocomposites based on quantum dot-initiated photocatalysis. ANGEW, 64(3), e202415645. (www)

  @article{ , abstract = {Integrating quantum dots (QDs) into polymer matrix to form nanocomposites without compromising the QD photoluminescence (PL) is crucial to emerging QD light-emitting and solar energy conversion fields. However, the most widely-used bulk polymerization technique, where monomers serve as the QD solvent, usually leads to QD PL quenching caused by radical initiators. Here we demonstrate high-brightness nanocomposites with near-unity PL quantum yield (QY), through a novel QDs-catalyzed (-initiated) bulk polymerization without using any radical initiators. Different from previous reports where QDs were designed as photo-sensitizers/catalysts (always with cocatalysts) and hence non-emissive in catalytic conditions, our QDs combine high brightness with highly effective catalysis, a combination that was previously considered to be hardly possible. In our case, apart from emitting light (at a large probability), the photoexcited QDs act as ‘overall reaction’ catalysts by simultaneously employing photoexcited electrons and holes to produce active radicals without the need of any sacrificial agents. These active radicals, though with a small amount, are sufficient to initiate effective chain reaction-dominated bulk polymerization, eliminating the requirement of extra radical initiators. This study provides new insights for understanding and development of QDs for energy applications.}, archive = {J_ANGEW}, author = {Zhuang Hu and Feng Gao and Haiyan Qin and Xin Cui and Linqin Wang and Wenxing Yang and Chunyuan Lu and Biaobiao Zhang and Licheng Sun}, doi = {10.1002/anie.202415645}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415645}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bright nanocomposites based on quantum dot-initiated photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Dual-anionic coordination manipulation induces phosphorus and boron-rich gradient interphase towards stable and safe sodium metal batteries. ANGEW, 64(3), e202415644. (www)

  @article{ , abstract = {High-voltage sodium metal batteries (SMBs) present a viable pathway towards high-energy-density sodium-based batteries due to the competitive cost advantage and abundant supply of sodium resources. However, they still suffer from severe capacity decay induced by the notorious decomposition of the electrolyte under high voltage and unstable cathode/electrolyte interphase (CEI). In addition, the high reactivity of Na metal and flammable electrolytes push SMBs to their safety limits. Herein, a special dual-anion aggregated Na + solvation structure is designed in a nonflammable trimethyl phosphate-based localized high-concentration electrolyte, and a gradient CEI enriched with phosphorus and boron compounds is formed on the cathode. This thin and stable interphase effectively suppresses the parasitic reaction, improves the interfacial stability of the cathode, and facilitates Na + transport through the interface by the synergistic effect of multi-components, thus optimizing the cycling stability and safety of SMBs. The Na 0.95 Ni 0.4 Fe 0.15 Mn 0.3 Ti 0.15 O 2 //Na batteries employing such electrolyte provide a discharge capacity of 167.5 mAh g −1 and high retention in the capacity of 85.2 % after 800 cycles at 1 C. This approach offers a general strategy for the design of flame-retardant high-voltage electrolytes and the practical application of SMBs.}, archive = {J_ANGEW}, author = {Yi-Hu Feng and Mengting Liu and Wenli Qi and Haoliang Liu and Qiang Liu and Chao Yang and Yongwei Tang and Xu Zhu and Shuai Sun and Yuan-Meng Li and Tian-Ling Chen and Bing Xiao and Xiao Ji and Ya You and Peng-Fei Wang}, doi = {10.1002/anie.202415644}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual-anionic coordination manipulation induces phosphorus and boron-rich gradient interphase towards stable and safe sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Atmosphere induces tunable oxygen vacancies to stabilize single-atom copper in ceria for robust electrocatalytic CO2 reduction to CH4. ANGEW, 64(3), e202415642. (www)

  @article{ , abstract = {Electrochemical carbon dioxide reduction (ECO 2 RR) shows great potential to create high-value carbon-based chemicals, while designing advanced catalysts at the atomic level remains challenging. The ECO 2 RR performance is largely dependent on the catalyst microelectronic structure that can be effectively modulated through surface defect engineering. Here, we provide an atmosphere-assisted low-temperature calcination strategy to prepare a series of single-atomic Cu/ceria catalysts with varied oxygen vacancy concentrations for robust electrolytic reduction of CO 2 to methane. The obtained Cu/ceria catalyst under H 2 environment (Cu/ceria-H 2 ) exhibits a methane Faraday efficiency (FE CH4 ) of 70.03 % with a turnover frequency (TOF CH4 ) of 9946.7 h −1 at an industrial-scale current density of 150 mA cm −2 in a flow cell. Detailed studies indicate the copious oxygen vacancies in the Cu/ceria-H 2 are conducive to regulating the surface microelectronic structure with stabilized Cu + active center. Furthermore, density functional theory calculations and operando ATR-SEIRAS demonstrate that the Cu/ceria-H 2 can markedly enhance the activation of CO 2 , facilitate the adsorption of pivotal intermediates *COOH and *CO, thus ultimately enabling the high selectivity for CH 4 production. This study presents deep insights into designing effective electrocatalysts for CO 2 to CH 4 conversion by controlling the surface microstructure via the reaction atmosphere.}, archive = {J_ANGEW}, author = {Fang Huang and Xiangyu Chen and Huanhuan Sun and Qingduo Zeng and Junjie Ma and Dong Wei and Jinliang Zhu and Zhengjun Chen and Taoyuan Liang and Xucai Yin and Xijun Liu and Jing Xu and Huibing He}, doi = {10.1002/anie.202415642}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415642}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atmosphere induces tunable oxygen vacancies to stabilize single-atom copper in ceria for robust electrocatalytic CO2 reduction to CH4}, volume = {64}, year = {2025}, }
• (2025). Organic materials with ultrabright phosphorescence at room temperature under physiological conditions for bioimaging. ANGEW, 64(3), e202415637. (www)

  @article{ , abstract = {In contrast to the high efficiency of room temperature phosphorescence in crystal states, the generally utilized nanoparticles of organic materials in bioimaging demonstrated sharply decreased performance by orders of magnitude under physiological conditions, badly limiting the realization of their unique advantages. This case, especially for organic red/near-infrared (NIR) phosphorescence materials, is not only the challenge present in reality but more importantly, for the theoretical problem of deeply understanding and avoiding the quenching effect by oxygen and water toward excited triplet states. Herein, thanks to the intelligent molecular design by the introduction of abundant hydrophobic chains and highly-branched structures, bright and persistent red/NIR phosphorescence under physiological conditions has been realized, which demonstrated the shielding effect towards oxygen, and the strengthened intermolecular interactions to suppress the non-radiative transitions. Accordingly, the record phosphorescence intensity of nanoparticles in bioimage, up to 8.21±0.36×10 8 p s −1 cm −2 sr −1 , was achieved, to realize the clear phosphorescence imaging of liver and tumors in living mice, even lymph nodes in rabbit models with high SBRs. This work afforded an efficient way to achieve the bright red/NIR phosphorescence nanoparticles, guiding their further applications in biology and medicine.}, archive = {J_ANGEW}, author = {Juqing Gu and Wentao Yuan and Kai Chang and Cheng Zhong and Yufeng Yuan and Jinghua Li and Yufeng Zhang and Tian Deng and Yuanyuan Fan and Likai Yuan and Siwei Liu and Yongzhen Xu and Sisi Ling and Chunyan Li and Zheng Zhao and Qianqian Li and Zhen Li and Ben Zhong Tang}, doi = {10.1002/anie.202415637}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic materials with ultrabright phosphorescence at room temperature under physiological conditions for bioimaging}, volume = {64}, year = {2025}, }
• (2025). Opal-inspired SiO2-mediated carbon dot doping enables the synthesis of monodisperse multifunctional afterglow nanocomposites for advanced information encryption. ANGEW, 64(3), e202415632. (www)

  @article{ , abstract = {Despite recent advancements in inorganic and organic phosphors, creating monodisperse afterglow nanocomposites (NCs) remains challenging due to the complexities of wet chemistry synthesis. Inspired by nanoinclusions in opal, we introduce a novel SiO 2 -mediated carbon dot (CD) doping method for fabricating monodisperse, multifunctional afterglow NCs. This method involves growing a SiO 2 shell matrix on monodisperse nanoparticles (NPs) and doping CDs into the SiO 2 shell under hydrothermal conditions. Our approach preserves the monodispersity of the parent NP@SiO 2 NCs while activating a green afterglow in the doped CDs with an impressive lifetime of 1.26 s. Additionally, this method is highly versatile, allowing for various core and dopant combinations to finely tune the afterglow through core-to-CD or CD-to-dye energy transfer. Our findings significantly enhance the potential of SiO 2 coatings, transforming them from merely enhancing the biocompatibility of NCs to serving as a versatile matrix for emitters, facilitating afterglow generation and paving the way for new applications.}, archive = {J_ANGEW}, author = {Shuaimeng Guan and Xue Chen and Rui Yu and Weidong Xu and Zhongbin Wu and Yung Doug Suh and Xiaowang Liu and Wei Huang}, doi = {10.1002/anie.202415632}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415632}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Opal-inspired SiO2-mediated carbon dot doping enables the synthesis of monodisperse multifunctional afterglow nanocomposites for advanced information encryption}, volume = {64}, year = {2025}, }
• (2025). Reduction polymerization of CO2 with phenylene silanes catalyzed by single component B(C6F5)3. ANGEW, 64(3), e202415626. (www)

  @article{ , abstract = {CO 2 is an abundant C1 resource but a green-house gas and chemically inert. Thus, its utilization has been a promising but challenging project. Herein, we report the unprecedented polymerization of CO 2 and C 6 H 4 (SiMe 2 H) 2 using B(C 6 F 5 ) 3 alone under mild conditions to give poly(silphenylene siloxane) accompanied by releasing CH 4 . The copolymerization can be extended to comonomers of phenylene silanes bearing functional groups. Moreover, it combines with Piers-Rubinsztajn reaction to establish a tandem polymerization system to achieve super thermal resistant poly(siloxane-co-silphenylene siloxane)s. Density functional theory reveals that B(C 6 F 5 ) 3 is activated by silanes to form free HB(C 6 F 5 ) 2 , which is the true active species for CO 2 reducing to borylformate, the rate controlling step of the polymerization procedure. The subsequent multiple reductions of borylformate to CH 4 and the step-growth to poly(silphenylene siloxane)s can be fulfilled by both B(C 6 F 5 ) 3 and HB(C 6 F 5 ) 2 , and the former shows a slightly higher activity. This work opens a new avenue of utilizing CO 2 to fabricate polysiloxanes that is unable to access using current manners.}, archive = {J_ANGEW}, author = {Wenhao He and Bingwen Li and Yuxuan Li and Xinli Liu and Dongmei Cui}, doi = {10.1002/anie.202415626}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415626}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reduction polymerization of CO2 with phenylene silanes catalyzed by single component B(C6F5)3}, volume = {64}, year = {2025}, }
• (2025). Manganese(I)-catalyzed access to enantioenriched chiral aziridine phosphines. ANGEW, 64(3), e202415623. (www)

  @article{ , abstract = {Herein, we present the first catalytic asymmetric nucleophilic addition of diarylphosphines to 2 H -azirines, facilitated by a chiral Mn(I) complex. This method not only provides access to novel class of derivatives of the aziridine core – a structural motif recognized for its antitumor and antibacterial properties – but also introduces a phosphine moiety alongside the generation of an NH moiety within a strained three-membered ring. The discovery of this new Mn(I) complex that both enables the reaction and induces stereoselectivity is pivotal, as it underscores the significant potential of this earth-abundant metal in advancing asymmetric catalysis.}, archive = {J_ANGEW}, author = {Chuang Ni and Tizian-Frank Ramspoth and Marta Castiñeira Reis and Syuzanna R. Harutyunyan}, doi = {10.1002/anie.202415623}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415623}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manganese(I)-catalyzed access to enantioenriched chiral aziridine phosphines}, volume = {64}, year = {2025}, }
• (2025). Designing a refined multi-structural polymer electrolyte framework for highly stable lithium-metal batteries. ANGEW, 64(3), e202415617. (www)

  @article{ , abstract = {Rational structural designs of solid polymer electrolytes featuring rich interface-phase morphologies can improve electrolyte connection and rapid ion transport. However, these rigid interfacial structures commonly result in diminished or entirely inert ionic conductivity within their bulk phase, compromising overall electrolyte performance. Herein, a multi-component ion-conductive electrolyte was successfully designed based on a refined multi-structural polymer electrolyte (RMSPE) framework with uniform Li + solvation chemistry and rapid Li + transporting kinetics. The RMSPE framework is constructed via polymerization-induced phase separation based on a rational combination of lithiophilic components and rigid/flexible chain units with significant hydrophobic/hydrophilic contrasts. Further refined by coating a robust polymer network, this all-organic design endows a homogeneous micro-nano porous structure, providing a novel framework favorable for rapid ion transport in both its soft interfacial and bulk phases. The RMSPE exhibited excellent ion conductivity of 1.91 mS cm −1 at room temperature and a high Li + transference number of 0.7. Assembled symmetrical Li cells realized stable cycling for over 2400 h at 3.0 mA cm −2 . LiFePO 4 full batteries demonstrated a long lifespan of 3300 cycles with a capacity retention of 93.5 % and stable cycling performance at −35 °C. This innovative design concept offers a promising perspective for achieving high-performance polymer-based Li metal batteries.}, archive = {J_ANGEW}, author = {Weiting Ma and Xiurui Cui and Yong Chen and Shuang Wan and Shunshun Zhao and Jiajun Gong and Guoxiu Wang and Shimou Chen}, doi = {10.1002/anie.202415617}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415617}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Designing a refined multi-structural polymer electrolyte framework for highly stable lithium-metal batteries}, volume = {64}, year = {2025}, }
• (2025). A urease-based pH photoswitch: A general route to light-to-pH transduction. ANGEW, 64(3), e202415614. (www)

  @article{ , abstract = {New approaches for the integration of chemical and physical stimuli to control the dynamics of artificial enzymatic reaction networks (ERNs) are needed. Here, we present a general approach to convert a light stimulus into a time-programmed pH response. We developed and characterized a panel of photoswitchable inhibitors of urease. Urease activity, now regulated by light via the photoinhibitors, leads to an increase in pH upon hydrolysis of urea into ammonia. Careful choice of characteristics of light, and concentrations of enzyme, substrate, and photoinhibitor, allowed us to control the timing of the pH transition. Furthermore, as all enzymes have an activity–pH profile, the urease photoinhibitor system can be used to regulate the activities of other enzymes in small reaction networks.}, archive = {J_ANGEW}, author = {Nikita M. Ivanov and Alexandar I. Slivkov and Wilhelm T. S. Huck}, doi = {10.1002/anie.202415614}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415614}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A urease-based pH photoswitch: A general route to light-to-pH transduction}, volume = {64}, year = {2025}, }
• (2025). Endo-encapsulated multi-resonance dendrimers with through-space interactions for efficient narrowband blue-emitting solution-processed OLEDs. ANGEW, 64(3), e202415607. (www)

  @article{ , abstract = {Different from conventional luminescent dendrimers with fluorophore tethered outside to dendron, here we first developed endo -encapsulated luminescent dendrimers with multi-resonance (MR) fluorophore embedded inside of carbazole dendrons by growing dendrons through 1,8-positions of central carbazole moiety to create a cavity for accommodating the fluorophore. This endo -encapsulated structure not only shields the fluorophore to fully resist aggregation-caused spectral broadening, but also induce through-space interactions between dendron and fluorophore via intramolecular π-stacking, giving lowered singlet state energy and reduced singlet-triplet energy splitting to accelerate reverse intersystem crossing (RISC) from triplet to singlet states. The resultant dendrimer containing 1,8-linked second-generation carbazole dendrons and boron, sulfur-doped polycyclic MR fluorophore exhibits narrowband blue emission at 471 nm with FWHM kept at 34 nm even in neat film, together with ~4 times enhancement of RISC rate constant compared to its exo- tethered counterpart. Solution-processed OLEDs based on the endo -encapsulated dendrimer reveal efficient narrowband blue emissions with maximum external quantum efficiency of 22.6 %, representing the best device efficiency for blue-emitting multi-resonance dendrimers so far.}, archive = {J_ANGEW}, author = {Yufei Chang and Kaiyuan Zhang and Lei Zhao and Xingdong Wang and Shumeng Wang and Shiyang Shao and Lixiang Wang}, doi = {10.1002/anie.202415607}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415607}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Endo-encapsulated multi-resonance dendrimers with through-space interactions for efficient narrowband blue-emitting solution-processed OLEDs}, volume = {64}, year = {2025}, }
• (2025). Unravelling the effect of crystal facet of derived-copper catalysts on the electroreduction of carbon dioxide under unified mass transport condition. ANGEW, 64(3), e202415590. (www)

  @article{ , abstract = {Altering the physical structure and chemical property of copper, i.e., particle size, surface morphology, composition or crystal facet, has been demonstrated to be effective in steering the selectivity of products in electrochemical reduction of carbon dioxide. However, these modifications generally result in the change of active surface area, leading to differences in geometric current density and local pH, which are also demonstrated to be the key factors for observed selectivity change. In this work, we deconvolute the effect of mass transport and local pH from the effect of crystal facet by investigating five copper-based catalysts with identical roughness factor for electrochemical reduction of carbon dioxide in an H-cell. Interestingly, CuO-derived catalyst stands out as the best catalyst for C−C coupling. At −1.07 V vs. RHE, the faradaic efficiency of C 2+ product reaches 44.3 %, with a partial current density of −21.6 mA cm −2 . Electrochemical adsorption of *OH reveals that the C 2+ product selectivity of derived-copper catalysts correlates positively with the ratio of Cu(100)/Cu(110) of five catalysts. Additionally, in situ Raman spectroscopy reveals that the percentage of low-frequency-band linear CO (LFB-CO), which is attributed to the adsorbed *CO on Cu(100) facet, increases with the C−C coupling efficiency.}, archive = {J_ANGEW}, author = {Zi-Hao Zhao and Dan Ren}, doi = {10.1002/anie.202415590}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415590}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unravelling the effect of crystal facet of derived-copper catalysts on the electroreduction of carbon dioxide under unified mass transport condition}, volume = {64}, year = {2025}, }
• (2025). Single-component high-resolution dual-tone EUV photoresists based on precision self-immolative polymers. ANGEW, 64(3), e202415588. (www)

  @article{ , abstract = {Electron beam (EB) and extreme ultraviolet (EUV) lithography are advanced techniques capable of achieving sub-10 nm resolutions, critical for fabricating next-generation nanostructures and semiconductor devices. However, developing EUV photoresists that meet all demands for resolution, line edge roughness (LER), and sensitivity (RLS) remains a significant challenge. Herein, we introduce high-performance photoresists based on single-component self-immolative polymers (SIPs) with inherent signal amplification via cascade degradation. These SIPs function as dual-tone photoresists under both EB and EUV lithography, with performance primarily determined by the exposure dose. Lithographic evaluations show that discrete SIPs provide significant improvements over disperse counterparts, achieving higher resolution and reduced LER. Specifically, a discrete SIP with a DP of 12 produces a line-space pattern with a resolution of approximately 18 nm and an LER of 1.8 nm, compared to 21 nm resolution and 2.5 nm LER for disperse SIPs. Additionally, these SIP-based photoresists, enriched with aromatic structures, exhibit excellent etch resistance. The single-component nature and potential to address the RLS trade-off underscore the promise of discrete SIPs for EUV lithography.}, archive = {J_ANGEW}, author = {Jie Cen and Wen Liu and Jie Xu and Xiuxia Wang and Jialin Zhang and Jin Zhang and Zhengyu Deng and Chenggang Zhou and Jinming Hu and Shiyong Liu}, doi = {10.1002/anie.202415588}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415588}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-component high-resolution dual-tone EUV photoresists based on precision self-immolative polymers}, volume = {64}, year = {2025}, }
• (2025). End-extended conjugation strategy to reduce the efficiency-stability-mechanical robustness gap in binary all-polymer solar cells. ANGEW, 64(3), e202415583. (www)

  @article{ , abstract = {Concurrently achieving high efficiency, mechanical robustness and thermal stability is critical for the commercialization of all-polymer solar cells (APSCs). However, APSCs usually demonstrate complicated morphology, primarily attributed to the polymer chain entanglement which has a detrimental effect on their fill factors (FF) and morphology stability. To address these concerns, an end-group extended polymer acceptor, PY-NFT, was synthesized and studied. The morphology analysis showed a tightly ordered molecular packing mode and a favorable phase separation was formed. The PM6 : PY-NFT-based device achieved an exceptional PCE of 19.12 % (certified as 18.45 %), outperforming the control PM6 : PY-FT devices (17.14 %). This significant improvement highlights the record-high PCE for binary APSCs. The thermal aging study revealed that the PM6 : PY-NFT blend exhibited excellent morphological stability, thereby achieving superior device stability, retaining 90 % of initial efficiency after enduring thermal stress (65 °C) for 1500 hours. More importantly, the PM6 : PY-NFT blend film exhibited outstanding mechanical ductility with a crack onset strain of 24.1 %. Overall, rational chemical structure innovation, especially the conjugation extension strategy to trigger appropriate phase separation and stable morphology, is the key to achieving high efficiency, improved thermal stability and robust mechanical stability of APSCs.}, archive = {J_ANGEW}, author = {Xu Zhang and Huanhuan Gao and Yuanyuan Kan and Xunchang Wang and Wenqing Zhang and Kangkang Zhou and Huajun Xu and Long Ye and Renqiang Yang and Yingguo Yang and Xiaotao Hao and Yanna Sun and Ke Gao}, doi = {10.1002/anie.202415583}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415583}, shortjournal = {Angew. Chem. Int. Edit.}, title = {End-extended conjugation strategy to reduce the efficiency-stability-mechanical robustness gap in binary all-polymer solar cells}, volume = {64}, year = {2025}, }
• (2025). Autocatalytic reaction networks: A pathway to spatial temporal mastery in dynamic materials. ANGEW, 64(3), e202415582. (www)

  @article{ , abstract = {Autocatalytic reaction present a significant opportunity for the precise spatial and temporal control of dynamic materials, mimicking the characteristics of living matter within autonomous chemical systems. Herein, we have crafted an autocatalytic chemical reaction network (CRN) designed to be incorporated into a dynamic system, allowing for efficient control of both sol(I)-gel and gel-sol(II) transitions through autocatalytic fronts. The CRN incorporates two autocatalytic reactions. The first reaction promotes the formation of disulfide crosslinks while increasing the local pH through base product generation, catalyzing further disulfide bond formation and initiating a polymerization front that transforms the liquid phase into a gel. A subsequent, slower reaction triggered at the gel/air interface, resulted in the breakage of disulfide crosslinks, transforming the gel back into a liquid state through accelerating fronts. The dynamics of these autocatalytic fronts are accurately predicted by a reaction-diffusion model, providing a theoretical framework for system preprogramming. Moreover, our results show that the reversible sol-gel transition can be reliably repeated multiple times. This approach not only enhances our understanding of autocatalytic CRNs but also pioneers a new approach for developing dynamic materials with life-like properties, significantly impacting material science and bioengineering.}, archive = {J_ANGEW}, author = {Yingshuai Zhao and Bohan Li and Xiaoming Fu and Peng Zhao and Yuanfeng Zhao and Wei Zhou and Yan Lu and Yijun Zheng}, doi = {10.1002/anie.202415582}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415582}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Autocatalytic reaction networks: A pathway to spatial temporal mastery in dynamic materials}, volume = {64}, year = {2025}, }
• (2025). Multi-stage optimization of pore size and shape in pore-space-partitioned Metal–Organic frameworks for highly selective and sensitive benzene capture. ANGEW, 64(3), e202415576. (www)

  @article{ , abstract = {Compared to exploratory development of new structure types, pushing the limits of isoreticular synthesis on a high-performance MOF platform may have higher probability of achieving targeted properties. Multi-modular MOF platforms could offer even more opportunities by expanding the scope of isoreticular chemistry. However, navigating isoreticular chemistry towards best properties on a multi-modular platform is challenging due to multiple interconnected pathways. Here on the multi-modular pacs (partitioned acs) platform, we demonstrate accessibility to a new regime of pore geometry using two independently adjustable modules (framework-forming module 1 and pore-partitioning module 2). A series of new pacs materials have been made. Benzene/cyclohexane selectivity is tuned, progressively, from 4.5 to 15.6 to 195.4 and to 482.5 by pushing the boundary of the pacs platform towards the smallest modules known so far. The exceptional stability of these materials in retaining both porosity and single crystallinity enables single-crystal diffraction studies of different crystal forms (as-synthesized, activated, guest-loaded) that help reveal the mechanistic aspects of adsorption in pacs materials.}, archive = {J_ANGEW}, author = {Yichong Chen and Wei Wang and Samuel Alston and Yuchen Xiao and Pooja Ajayan and Xianhui Bu and Pingyun Feng}, doi = {10.1002/anie.202415576}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415576}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-stage optimization of pore size and shape in pore-space-partitioned Metal–Organic frameworks for highly selective and sensitive benzene capture}, volume = {64}, year = {2025}, }
• (2025). Simultaneous cycloadditions in the solid state via supramolecular assembly. ANGEW, 64(3), e202415567. (www)

  @article{ , abstract = {Chemical reactions conducted in the solid phase (specifically, crystalline) are much less numerous than solution reactions, primarily due to reduced motion, flexibility, and reactivity. The main advantage of crystalline-state transformations is that reactant molecules can be designed to self-assemble into specific spatial arrangements, often leading to high control over product regiochemistry and/or stereochemistry. In crystalline-phase transformations, typically only one type of reaction occurs, and a sacrificial template molecule is frequently used to facilitate self-assembly, similar to a catalyst or enzyme. Here, we demonstrate the first system designed to undergo two chemically unique and orthogonal cycloaddition reactions simultaneously within a single crystalline solid. Well-controlled supramolecular self-assembly of two molecules containing different reactive moieties affords orthogonal reactivity without use of a sacrificial template. Using only UV light, the simultaneous [2+2] and [4+4] cycloadditions are achieved regiospecifically, stereospecifically, and products are obtained in high yield, whereas a simultaneous solution-state reaction affords a mixture of isomers in low yield. Application of dually-reactive systems toward (supra)molecular solar thermal storage materials is also discussed. This work demonstrates fundamental chemical approaches for orthogonal reactivity in the crystalline state and highlights the complexity and reversibility that can be achieved with supramolecular design.}, archive = {J_ANGEW}, author = {Navkiran Juneja and Gary C. George and Kristin M. Hutchins}, doi = {10.1002/anie.202415567}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415567}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous cycloadditions in the solid state via supramolecular assembly}, volume = {64}, year = {2025}, }
• (2025). Site-selective construction of N-linked glycopeptides through photoredox catalysis. ANGEW, 64(3), e202415565. (www)

  @article{ , abstract = {The glycosylation of peptides and proteins can significantly impact their intrinsic properties, such as conformation, stability, antigenicity, and immunogenicity. Current methods for preparing N-linked glycopeptides typically rely on amide bond formation, which can be limited by the presence of reactive functional groups like acids and amines. Late-stage functionalization of peptides offers a promising approach to obtaining N-linked glycopeptides. In this study, we demonstrate the preparation of N-linked glycopeptides through a photoredox-catalyzed site-selective Giese addition between N-glycosyl oxamic acid and peptides containing dehydroalanine (Dha) under visible light conditions. Unlike traditional methods that rely on the coupling of aspartic acid and glycosylamine, this approach utilizes the conjugation of N-glycosylated carbamoyl radicals with Dha, facilitating the straightforward modification of complex peptides.}, archive = {J_ANGEW}, author = {Bingcheng Wei and Ping Huang and Xinyao Wang and Zhi Liu and Feng Tang and Wei Huang and Bing Liu and Farong Ye and Ping Wang}, doi = {10.1002/anie.202415565}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415565}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Site-selective construction of N-linked glycopeptides through photoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Photochemically triggered and autonomous oscillatory pH-modulated transient Assembly/Disassembly of DNA microdroplet coacervates. ANGEW, 64(3), e202415550. (www)

  @article{ , abstract = {The assembly of pH-responsive DNA-based, phase-separated microdroplets (MDs) coacervates, consisting of frameworks composed of Y-shaped nucleic acid modules crosslinked by pH-responsive strands, is introduced. The phase-separated MDs reveal dynamic pH-stimulated switchable or oscillatory transient depletion and reformation. In one system, a photoisomerizable merocyanine/spiropyran photoacid is used for the light-induced pH switchable modulation of the reaction medium between the values pH=6.0–4.4. The dynamic transient photochemically-induced switchable depletion/reformation of phase-separated MDs, follows the rhythm of pH changes in solution. In a second system, the Landolt oscillatory reaction mixture pH 7.5→4.2→7.5 is applied to stimulate the oscillatory depletion/reformation of the MDs. The autonomous dynamic oscillation of the assembly/disassembly of the MDs follows the oscillating pH rhythm of the reaction medium.}, archive = {J_ANGEW}, author = {Yunlong Qin and Yang Sung Sohn and Xiang Li and Rachel Nechushtai and Junji Zhang and He Tian and Itamar Willner}, doi = {10.1002/anie.202415550}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photochemically triggered and autonomous oscillatory pH-modulated transient Assembly/Disassembly of DNA microdroplet coacervates}, volume = {64}, year = {2025}, }
• (2025). Fully exposed ru clusters for the efficient multi-step toluene hydrogenation reaction. ANGEW, 64(3), e202415542. (www)

  @article{ , abstract = {Liquid organic hydrogen carriers (LOHCs) are attractive platform molecules that play an important role in hydrogen energy storage and utilization. The multi-step hydrogenation of toluene (TOL) to methylcyclohexane (MCH) has been widely studied in the LOCHs systems, due to their relatively low toxicity and reasonable hydrogen storage capacity. Noble metal catalysts such as Ru has exhibited good performance in multi-step hydrogenation reactions, while the application is still hindered by their high cost and low specific activity. Therefore, the primary challenge lies in the development of noble metal catalysts with both robust activity and efficient atomic utilization. In this study, a series of Ru species ranging from single atoms, fully exposed clusters to nanoparticles were fabricated to investigate their structural evolution in the TOL multi-step hydrogenation reaction. The fully exposed and atomically dispersed Ru clusters, composed of an average of 3 Ru atoms, exhibit superior catalytic performance and recycle ability in TOL multi-step hydrogenation. Moreover, it delivers a high turnover frequency of 9850.3 h −1 under the relatively mild reaction (100 °C, 1.5 MPa), compared with those of single atoms and nanoparticles, and shows a notable advantage over catalysts reported in previous studies. From density functional theory (DFT) calculations, the overall barrier of the TOL multi-step hydrogenation reaction over the fully exposed Ru clusters is significantly lower than that of single atoms and nanoparticles, resulting in its higher activity. The present work provides an efficient strategy to regulate the reaction pathway of multi-step complicated catalytic reactions by designing fully exposed metal cluster catalysts.}, archive = {J_ANGEW}, author = {Yue Wang and Hancheng Yu and Yurong He and Shengling Xiang and Xuetao Qin and Lini Yang and Jiawei Chen and Yang Si and Jingwang Zhang and Jiangyong Diao and Ning Wang and Mi Peng and Ding Ma and Hongyang Liu}, doi = {10.1002/anie.202415542}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415542}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fully exposed ru clusters for the efficient multi-step toluene hydrogenation reaction}, volume = {64}, year = {2025}, }
• (2025). Reviving multivalent-metal anodes in simple salt electrolytes via component modifier design. ANGEW, 64(3), e202415540. (www)

  @article{ , abstract = {Using combinatory electrolyte blends represents an imperative avenue to achieve good magnesium (Mg)-metal anode compatibility and commercial feasibility in fields of promising rechargeable Mg batteries. However, fundamental challenges of how to manipulate component modifier reactivity on molecule level still remain to be solved. Here, molecular structure design concepts towards seeking bromophenyl complex-based component modifiers has been proposed according to implications of electron-donating and/or electron-withdrawing substituents on Br−C bond dissociation reactivity. Exceptional Mg electro-plating/stripping properties (a stable cycle life of 250 days in Mg//Cu asymmetric cells) have been firstly achieved in a simple salt electrolyte with 1-(3-bromophenyl)-N,N-dimethylmethanamine (BPDMA) as optimal component modifier. Comprehensive analyses disclose the unique electrochemically-active Br-containing ion-pairs formation, such as [(Mg 2+ ) 2 (TFSI − )Br − ] 2+ and [(Mg 2+ ) 2 (TFSI − )(Br − )(G2) 2 ] 2+ , which results in the much thinner Br − containing and organic–inorganic mixed interphases on Mg-metal anodes. Furthermore, conventional MgSO 4 -based electrolytes and even calcium (Ca)-ion electrolytes can also be revived by similar strategy, demonstrating its generality and superiority.}, archive = {J_ANGEW}, author = {Hang Zhou and Wenhao Sun and Xiaozheng Su and Mingyu Liu and Zhenfang Zhou and Aobing Du and Shanmu Dong and Qingfu Wang and Zhonghua Zhang and Guicun Li and Guanglei Cui}, doi = {10.1002/anie.202415540}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415540}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reviving multivalent-metal anodes in simple salt electrolytes via component modifier design}, volume = {64}, year = {2025}, }
• (2025). Structurally asymmetric Ni−O−Mn node in Metal–Organic layers on carbon nitride support for CO2 photoreduction. ANGEW, 64(3), e202415538. (www)

  @article{ , abstract = {The Jahn–Teller (J–T) effect-induced lattice distortion presents an advantageous approach to tailor the electronic structure and CO 2 adsorption properties of catalytic centers, consequently conferring desirable photocatalytic CO 2 reduction activity and selectivity. Nevertheless, achieving precise J–T distortion control over catalytic sites to enhance CO 2 adsorption/activation and target-product desorption remains a formidable challenge. In this work, we successfully induced J–T lattice distortion in neighboring Ni sites by exchanging high-spin Mn 2+ into Ni−O−Ni nodes. EXAFS results and DFT simulations revealed that the highly asymmetric Ni−O−Mn nodes induced structural contraction (shortened Ni−O bonds) in the adjacent Ni−O lattice. The magnetic hysteresis loop (M−H) confirmed that the introduction of Mn 2+ increased the number of spin electrons, thereby increasing the magnetization intensity. The spin mismatch between photogenerated electrons and holes suppressed charge recombination. Significantly, the d orbitals of the Ni sites in the Ni−O−Mn nodes exhibited strong orbital hybridization with the p orbitals of CO 2 , as evidenced by the enhanced d-p orbital overlap, facilitating rapid CO 2 adsorption and activation. Consequently, the sample featuring lattice-mismatched Ni−O−Mn nodes exhibited an 8.79-fold enhancement in CO production rate compared to the Ni−O−Ni nodes, in the absence of cocatalysts and sacrificial reagents.}, archive = {J_ANGEW}, author = {Chen Guan and Xiaoyang Yue and Yulong Liao and Quanjun Xiang}, doi = {10.1002/anie.202415538}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415538}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structurally asymmetric Ni−O−Mn node in Metal–Organic layers on carbon nitride support for CO2 photoreduction}, volume = {64}, year = {2025}, }
• (2025). Self-assembled hydrazide-based nanochannels: Efficient water translocation and salt rejection. ANGEW, 64(3), e202415510. (www)

  @article{ , abstract = {Nature has ingeniously developed specialized water transporters that effectively reject ions, including protons, while transporting water across membranes. These natural water channels, known as aquaporins (AQPs), have inspired the creation of Artificial Water Channels (AWCs). However, replicating superfast water transport with synthetic molecular structures that exclude salts and protons is a challenging task. This endeavor demands the coexistence of a suitable water-binding site and a selective filter for precise water transportation. Here, we present small-molecule hydrazides 1 b–1 d that self-assemble into a rosette-type nanochannel assembly through intermolecular hydrogen bonding and π-π stacking interactions, and selectively transport water molecules across lipid bilayer membranes. The experimental analysis demonstrates notable permeability rates for the 1 c derivative, enabling approximately 3.18×10 8 water molecules to traverse the channel per second. This permeability rate is about one order of magnitude lower than that of AQPs. Of particular significance, the 1 c ensures exclusive passage of water molecules while effectively blocking salts and protons. MD simulation studies confirmed the stability and water transport properties of the water channel assembly inside the bilayer membranes at ambient conditions.}, archive = {J_ANGEW}, author = {Abhishek Mondal and Debashis Mondal and Susmita Sarkar and Umesh Shivpuje and Jagannath Mondal and Pinaki Talukdar}, doi = {10.1002/anie.202415510}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415510}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled hydrazide-based nanochannels: Efficient water translocation and salt rejection}, volume = {64}, year = {2025}, }
• (2025). α-nucleophilic addition to α,β-unsaturated carbonyl compounds via photocatalytically generated α-carbonyl carbocations. ANGEW, 64(3), e202415496. (www)

  @article{ , abstract = {We report the photocatalytic oxidation of α-carbonyl radicals of amides or esters to the corresponding α-carbonyl carbocations through super photoreductant CBZ6 induced redox-neutral photocatalysis. The α-carbonyl radicals are formed by the β-addition of alkyl radicals generated in situ by the photocatalytic fragmentation of N -hydroxyphthalimide esters to the α,β-unsaturated amides and esters. This method enables the α-nucleophilic addition of hydroxyl or alkoxyl radicals to amides and esters without any prefunctionalization.}, archive = {J_ANGEW}, author = {Chong-Jin Zhang and Yu Sun and Jie Gong and Hao Zhang and Zhen-Zhen Liu and Fang Wang and Jin-Xiang Chen and Jian-Ping Qu and Yan-Biao Kang}, doi = {10.1002/anie.202415496}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415496}, shortjournal = {Angew. Chem. Int. Edit.}, title = {α-nucleophilic addition to α,β-unsaturated carbonyl compounds via photocatalytically generated α-carbonyl carbocations}, volume = {64}, year = {2025}, }
• (2025). Energy-transfer enabled 1,4-aryl migration. ANGEW, 64(3), e202415495. (www)

  @article{ , abstract = {Functional group translocation is undoubtedly a pivotal synthetic transformation in organic chemistry. Numerous types of reactions involving radical 1,2-aryl or 1,4-aryl migration via electron transfer mechanism have been extensively investigated. Nevertheless, energy-transfer enabled 1,4-arylation remains unknown. Herein we disclose that an unprecedented di-π-ethane rearrangement featuring 1,4-aryl migration facilitated by energy transfer catalysis under visible light conditions. The newly developed mild protocol exhibits tolerance towards diverse functional groups and enables the migration of a multitude of aromatic rings, encompassing both electron-withdrawing and electron-rich functional groups. The open-shell strategy has also found successful application in the modification of several drugs. Large-scale experiments, continuous-flow experiment, and versatile manipulation of products have demonstrated the robustness and potential utility of this synthetic method. Preliminary mechanistic studies have supported the involvement of radical species in this di-π-ethane rearrangement and have also provided evidence for the energy transfer mechanism.}, archive = {J_ANGEW}, author = {Shu-Ya Wen and Jun-Jie Chen and Yu Zheng and Jia-Xun Han and Huan-Ming Huang}, doi = {10.1002/anie.202415495}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415495}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Energy-transfer enabled 1,4-aryl migration}, volume = {64}, year = {2025}, }
• (2025). High-efficiency photo-assisted large current-density water splitting with mott-schottky heterojunctions. ANGEW, 64(3), e202415492. (www)

  @article{ , abstract = {The development of bifunctional photogenerated carrier-assisted electrocatalytic (PCA-EC) electrodes that operate with stability at large current-density remains a significant challenge. Herein, we demonstrate a simple sputtering-deposition process to synthesize a novel MnWO 4 /FeCoNi Mott-Schottky heterojunction coating and deposit it on a pure Ti substrate to prepare high-performance PCA-EC electrodes, which exhibits enhanced light absorption range/intensity and rapidly separated photogenerated electron-hole pairs. This design allows photogenerated electrons to directly participate in the hydrogen evolution reaction (HER), while the strong oxidation of photogenerated holes significantly reduces the defect formation energy of active metals, thereby facilitating the rapid reconstruction of highly active Ni(FeCo)OOH/MnOOH species for the oxygen evolution reaction (OER). As expected, the as-prepared electrode demonstrates the overpotentials of 64 mV for the HER and 204 mV for the OER at 10 mA cm −2 under illumination. Benefiting from the stable interface with Fe/Co/Ni-O−Mn/W bonding units, the dual-electrode photoassisted electrolytic cell achieves long-term stability at current densities of 500 and 1000 mA cm −2 . This work provides detailed insights into the enhancement mechanism of PCA-EC and contributes to the development of photo-assisted water splitting electrodes for large current-density applications.}, archive = {J_ANGEW}, author = {Minming Jiang and Jiang Xu and Yujie Chen and Luqi Wang and Paul Munroe and Zong-Han Xie and Shengjie Peng}, doi = {10.1002/anie.202415492}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415492}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-efficiency photo-assisted large current-density water splitting with mott-schottky heterojunctions}, volume = {64}, year = {2025}, }
• (2025). Electrolyte design enables stable and energy-dense potassium-ion batteries. ANGEW, 64(3), e202415491. (www)

  @article{ , abstract = {Free from strategically important elements such as lithium, nickel, cobalt, and copper, potassium-ion batteries (PIBs) are heralded as promising low-cost and sustainable electrochemical energy storage systems that complement the existing lithium-ion batteries (LIBs). However, the reported electrochemical performance of PIBs is still suboptimal, especially under practically relevant battery manufacturing conditions. The primary challenge stems from the lack of electrolytes capable of concurrently supporting both the low-voltage anode and high-voltage cathode with satisfactory Coulombic efficiency (CE) and cycling stability. Herein, we report a promising electrolyte that facilitates the commercially mature graphite anode (>3 mAh cm −2 ) to achieve an initial CE of 91.14 % (with an average cycling CE around 99.94 %), fast redox kinetics, and negligible capacity fading for hundreds of cycles. Meanwhile, the electrolyte also demonstrates good compatibility with the 4.4 V ( vs . K + /K) high-voltage K 2 Mn[Fe(CN) 6 ] (KMF) cathode. Consequently, the KMF||graphite full-cell without precycling treatment of both electrodes can provide an average discharge voltage of 3.61 V with a specific energy of 316.5 Wh kg −1 −(KMF+graphite), comparable to the LiFePO 4 ||graphite LIBs, and maintain 71.01 % capacity retention after 2000 cycles.}, archive = {J_ANGEW}, author = {Zhe Zhang and Xiaofang Wang and Jiacheng Zhu and Nan Li and Linlin Wang and Yusi Yang and Yifan Chen and Lulu Tan and Xiaogang Niu and Xuefeng Wang and Xiao Ji and Yujie Zhu}, doi = {10.1002/anie.202415491}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415491}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte design enables stable and energy-dense potassium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). One-pot transition-metal-free synthesis of alkynyl amides. ANGEW, 64(3), e202415472. (www)

  @article{ , abstract = {Alkynyl amides play crucial roles in organic synthesis in the production of bioactive compounds and valuable heterocycles. Despite numerous studies on their synthesis, challenges persist due to the necessity of harsh or hazardous conditions and the use of costly or unstable reagents. Herein, we present a one-pot method for the synthesis of all three bonds of the alkyne under transition-metal-free conditions. An important feature of this chemistry is the use of readily available feedstock chemicals, such as methyl esters and acetamides. This approach offers efficient access to a wide range of aryl and alkyl alkynyl amides and demonstrates excellent tolerance towards various functional groups in a sustainable and cost-effective manner.}, archive = {J_ANGEW}, author = {Yu Wu and Bárbara G. Sátiro and Jianyou Mao and Patrick J. Walsh}, doi = {10.1002/anie.202415472}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {One-pot transition-metal-free synthesis of alkynyl amides}, volume = {64}, year = {2025}, }
• (2025). Switching sides: Regiochemistry and functionalization dictate the photoswitching properties of imines. ANGEW, 64(3), e202415464. (www)

  @article{ , abstract = {Photoswitchable imines demonstrate light-dependent dynamic covalent chemistry and can function as molecular ratchets. However, the design of aryliminopyrazoles (AIPs) has been limited to N -pyrazole derivatives with ortho -pyrrolidine motifs. The impact of other functionalization patterns on the photoswitching properties remains unknown. Here, we present a systematic structure-property analysis and study how the photoswitching properties can be tuned through ortho - and para -functionalization of the phenyl ring in N -pyrazole and N -phenyl AIPs. This study establishes the first set of design rules for these AIP photoswitches and reports the most stable Z -isomer of an AIP to date, enabling its crystallization and resulting in the first reported crystal structure of a metastable Z -aldimine. Finally, we demonstrate that the AIPs are promising candidates for photoswitching in the condensed phase.}, archive = {J_ANGEW}, author = {Jiarong Wu and Lasse Kreimendahl and Jake L. Greenfield}, doi = {10.1002/anie.202415464}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415464}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switching sides: Regiochemistry and functionalization dictate the photoswitching properties of imines}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bond-regulated mechanochemical synthesis of covalent organic frameworks: Cocrystal precursor strategy for confined assembly. ANGEW, 64(3), e202415454. (www)

  @article{ , abstract = {Two-dimensional imine covalent organic frameworks (2D imine-COFs) are crystalline porous materials with broad application prospects. Despite the efforts into their design and synthesis, the mechanisms of their formation are still not fully understood. Herein, a one-pot two-step mechanochemical cocrystal precursor synthetic strategy is developed for efficient construction of 2D imine-COFs. The mechanistic investigation demonstrated that the cocrystal precursors of 4,4′,4′′-(1,3,5-triazine-2,4,6-triyl)trianiline ( TAPT ) and p -toluenesulphonic acid ( PTSA ) sufficiently regulate the crystalline structure of COF. Evidenced by characterizations and theoretical studies, a helical hydrogen-bond network was constructed by the N−H⋅⋅⋅O supramolecular synthons between amino and sulfonic groups in TAPT-PTSA , demonstrating the role of cocrystals in promoting the organized stacking of interlayer π–π interactions, layer arrangement, and interlayer spacing, thus facilitating the orderly assembly of COFs. Moreover, the protonation degree of TAPT amines, which tuned nucleophilic directionality, enabled the sequential progression of intra- and interlayer imine condensation reactions, inhibiting the formation of amorphous polymers. The transformation from cocrystal precursors to COFs was achieved through comprehensive control of hydrogen bond and covalent bond sites. This work significantly advances the concept of hydrogen-bond-regulated COF assembly and its mechanochemical method in the design and synthesis of 2D imine-COFs, further elucidating the mechanistic aspects of their mechanochemical synthesis.}, archive = {J_ANGEW}, author = {Hongguang Chen and Daming Feng and Fengxia Wei and Fang Guo and Anthony K. Cheetham}, doi = {10.1002/anie.202415454}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415454}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bond-regulated mechanochemical synthesis of covalent organic frameworks: Cocrystal precursor strategy for confined assembly}, volume = {64}, year = {2025}, }
• (2025). Crystal modulation of mn-based layered oxide toward long-enduring anionic redox with fast kinetics for sodium-ion batteries. ANGEW, 64(3), e202415450. (www)

  @article{ , abstract = {Mn-based layered oxide cathodes for sodium-ion batteries with anionic redox reactions hold great potential for energy storage applications due to their ultra-high capacity and cost effectiveness. However, achieving high capacity requires overcoming challenges such as oxygen-redox failure, sluggish kinetics, and structural degradation. Herein, we employ an innovative crystal modulation strategy, using Mn-based Na 0.72 Li 0.24 Mn 0.76 O 2 as a representative cathode material, which shows that the highly exposed {010} active facets enable an enhanced rate capability (119.6 mAh g −1 at 10 C) with fast kinetics. Meanwhile, the reinforced Mn−O bond inhibits excessive oxidation of lattice oxygen and O−O cohesion loss, stabilizing and maintaining a long-enduring reversible oxygen-redox activity (100 % high capacity retention after 100 cycles at 0.5 C and 84.28 % retention after 300 cycles at 5 C). Time-resolved operando two-dimensional X-ray diffraction reveals the robust structural stability, zero-strain behavior, and suppressed phase transition with ultra-low volume variation during cycling at different rates (0.1 C: 1.75 %, 1 C: 0.31 %, 5 C: 0.04 %). Additionally, the full cell coupled with hard carbon achieves a high energy density of approximately 211 Wh kg −1 with superior performance. This work highlights the significance of crystal modulation and presents a universal approach in developing Mn-based oxide cathodes with stable anionic redox for high-performance sodium-ion batteries.}, archive = {J_ANGEW}, author = {Gaoyuan Zhang and XingXing Yin and De Ning and Yan Chai and Ruijie Du and Dingbang Hao and Chunling Wang and Xueling Liu and Rui Gao and Jun Wang and Xiangdong Yao and Yongli Li and Dong Zhou}, doi = {10.1002/anie.202415450}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415450}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Crystal modulation of mn-based layered oxide toward long-enduring anionic redox with fast kinetics for sodium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Hydroxyl-binding induced hydrogen bond network connectivity on ru-based catalysts for efficient alkaline hydrogen oxidation electrocatalysis. ANGEW, 64(3), e202415447. (www)

  @article{ , abstract = {Understanding the role of adsorbed intermediates at the polarized catalyst-electrolyte interface on the structure of electrical double layer (EDL) is essential for developing highly efficient electrocatalysts. Here, we prepared a series of unconventional face-centered-cubic ( fcc ) phase Ru-based catalysts (i.e. fcc -Ru, fcc -RuCr, and fcc -RuCrW) by rational tuning the binding energetics of hydroxyl intermediate to engineer the electrochemical interface and boost the performance of alkaline hydrogen oxidation reaction (HOR). The introduction of oxyphilic metals Cr and W can regulate the orbital occupation of Ru, promote the adsorption of hydroxyl species, resulting in an anomalous behavior that HOR performance under alkaline media exceeds acidic media. Experimental results and theoretical calculations unravel that the modulated adsorption of hydroxyl species on the electrode surface are responsible for the reconstruction of interfacial water structure and dynamic evolution of free water molecules from nearest to the electrode surface to above the gap region in the EDL, thereby leading to significantly increased water connectivity and hydrogen bond network. Our work reveals a new understanding of the surface intermediates in controlling the dynamic process of interfacial water and hydrogen bonding network in HOR electrocatalysis, and will guide rational design of advanced electrocatalysts through electrochemical interfacial engineering.}, archive = {J_ANGEW}, author = {Jianchao Yue and Yunbo Li and Chaoyi Yang and Wei Luo}, doi = {10.1002/anie.202415447}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415447}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydroxyl-binding induced hydrogen bond network connectivity on ru-based catalysts for efficient alkaline hydrogen oxidation electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Scalable electro-biosynthesis of ectoine from greenhouse gases. ANGEW, 64(3), e202415445. (www)

  @article{ , abstract = {Converting greenhouse gases into valuable products has become a promising approach for achieving a carbon-neutral economy and sustainable development. However, the conversion efficiency depends on the energy yield of the substrate. In this study, we developed an electro-biocatalytic system by integrating electrochemical and microbial processes to upcycle CO 2 into a valuable product (ectoine) using renewable energy. This system initiates the electrocatalytic reduction of CO 2 to methane, an energy-dense molecule, which then serves as an electrofuel to energize the growth of an engineered methanotrophic cell factory for ectoine biosynthesis. The scalability of this system was demonstrated using an array of ten 25 cm 2 electrochemical cells equipped with a high-performance carbon-supported isolated copper catalyst. The system consistently generated methane at the cathode under a total partial current of approximately −37 A (~175 mmol CH4 h −1 ) and O 2 at the anode under a total partial current of approximately 62 A (~583 mmol O2 h −1 ). This output met the requirements of a 3-L bioreactor, even at maximum CH 4 and O 2 consumption, resulting in the high-yield conversion of CO 2 to ectoine (1146.9 mg L −1 ). This work underscores the potential of electrifying the biosynthesis of valuable products from CO 2 , providing a sustainable avenue for biomanufacturing and energy storage.}, archive = {J_ANGEW}, author = {Shuqi Guo and Chengbo Li and Yuehang Su and Xiaohan Huang and Chenyue Zhang and Yizhou Dai and Yuan Ji and Rongzhan Fu and Tingting Zheng and Qiang Fei and Daidi Fan and Chuan Xia}, doi = {10.1002/anie.202415445}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415445}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Scalable electro-biosynthesis of ectoine from greenhouse gases}, volume = {64}, year = {2025}, }
• (2025). An n-doping cross-linkable quinoidal compound as an electron transport material for fully stretchable inverted organic solar cells. ANGEW, 64(3), e202415440. (www)

  @article{ , abstract = {The photocatalytic activity and inherent brittleness of ZnO, which is commonly used as an electron transport layer (ETL) in inverted organic solar cells (OSCs), have impeded advancements in device stability and the development of fully stretchable OSCs. In this study, an intrinsically stretchable ETL for inverted OSCs through a side-chain cross-linking strategy has been developed. Specifically, cross-linking between bromine atoms on the side chains of a quinoidal compound and the amino groups in polyethylenimine resulted in a film, designated QBr-PEI-50, with high electrical conductivity (0.049 S/m) and excellent stretchability (crack-onset strain>45 %). When used as the ETL in inverted OSCs, QBr-PEI-50 was markedly superior to ZnO in terms of device performance and stability, yielding a power conversion efficiency (PCE) of 18.27 % and a T 80 lifetime exceeding 10000 h. Moreover, incorporation of QBr-PEI-50 in fully stretchable inverted OSCs yielded a PCE of 14.01 %, and 80 % of the initial PCE was maintained after 21 % strain, showcasing its potential for wearable electronics.}, archive = {J_ANGEW}, author = {Cheng Wang and Yufei Xin and Haoran Gu and Long Ye and Yongsheng Liu and Yinhua Zhou and Yunfeng Deng and Yanhou Geng}, doi = {10.1002/anie.202415440}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415440}, shortjournal = {Angew. Chem. Int. Edit.}, title = {An n-doping cross-linkable quinoidal compound as an electron transport material for fully stretchable inverted organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Establishing the comprehensive Structure−Activity relationship of the natural antibiotic Kibdelomycin/Amycolamicin. ANGEW, 64(3), e202415439. (www)

  @article{ , abstract = {Kibdelomycin (KBD) and amycolamicin (AMM) are potent natural antibiotics effective against antibiotic-resistant Gram-positive pathogens, including vancomycin-intermediate Staphylococcus aureus ( S. aureus , VISA), methicillin-resistant S. aureus (MRSA), and quinolone-resistant S. aureus (QRSA). Their antibacterial activity stems from an unprecedented dual mechanism: the lower binding sites occupy the adenosine triphosphate (ATP) binding pocket of bacterial type II topoisomerases, while the upper binding sites disrupt the enzyme dimer interface. This dual action, combined with their unique chemical structures, positions KBD and AMM as promising scaffolds for developing new antibiotics. However, the structure–activity relationship (SAR) of KBD/AMM remains underexplored due to their highly complex chemical structures. In this study, we utilized total synthesis to produce KBD/AMM analogs with various site modifications and evaluated their antimicrobial activities. Our findings establish the first comprehensive SAR for KBD/AMM, paving the way for the development of novel KBD/AMM-based antibiotics.}, archive = {J_ANGEW}, author = {Chenglong Chen and Yuyao Yin and Panrui Lu and Ting Han and Hui Wang and Chao Li}, doi = {10.1002/anie.202415439}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415439}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Establishing the comprehensive Structure−Activity relationship of the natural antibiotic Kibdelomycin/Amycolamicin}, volume = {64}, year = {2025}, }
• (2025). Efficient electrosynthesis of valuable para-benzoquinone from aqueous phenol on NiRu hybrid catalysts. ANGEW, 64(3), e202415438. (www)

  @article{ , abstract = {Electrocatalytic oxidation of aqueous phenol to para -benzoquinone ( p -BQ) offers a sustainable approach for both pollutant abatement and value-added chemicals production. However, achieving high phenol conversion and p -BQ yield under neutral conditions remains challenging. Herein, we report a Ni(OH) 2 -supported Ru nanoparticles (NiRu) hybrid electrocatalyst, which exhibits a superior phenol conversion of 96.5 % and an excellent p -BQ yield of 83.4 % at pH 7.0, significantly outperforming previously reported electrocatalysts. This exceptional performance benefits from the triple synergistic modulation of the NiRu catalyst, including enhanced phenol adsorption, increased p -BQ desorption, and suppressed oxygen evolution. By coupling a flow electrolyzer with an extraction-distillation separation unit, the simultaneous phenol removal and p -BQ recovery are realized. Additionally, the developed electrocatalytic system with the NiRu/C anode displays good stability, favorable energy consumption, and reduced greenhouse gas emissions for phenol-containing wastewater treatment, demonstrating its potential for practical applications. This work offers a promising strategy for achieving low-carbon emissions in phenol wastewater treatment.}, archive = {J_ANGEW}, author = {Fuqiang Liu and Wei Chen and Tong Wang and Juchao Zhang and Deyong Yang and Yinhao Dai and Guizi Liu and Jian Zhou and Shuangyin Wang and Xiaohong Guan}, doi = {10.1002/anie.202415438}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415438}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Efficient electrosynthesis of valuable para-benzoquinone from aqueous phenol on NiRu hybrid catalysts}, volume = {64}, year = {2025}, }
• (2025). Strengthen water O−H bond in electrolytes for enhanced reversibility and safety in aqueous aluminum ion batteries. ANGEW, 64(3), e202415436. (www)

  @article{ , abstract = {Aqueous aluminum-ion batteries present a promising prospect for large-scale energy storage applications, owing to the abundance, inherent safety, and the high theoretical capacity of aluminum. However, their voltage output and energy density are significantly hindered by challenges such as complex hydrogen evolution and uncontrollable solvation reactions. In this work, we demonstrate that water decomposition is restrain by increasing the electron density of water protons and increasing the dissociation energy of H 2 O through robust dipole interactions with highly polar dimethylformamide (DMF) molecules. Moreover, the incorporation of dimethyl methylphosphonate (DMMP) flame retardant effectively addresses the flammability risk arising from a substantial presence of organic additives The in-depth study with experimental and theoretical simulations reveals that the water-poor solvation structure with reduced water activity is achieved, which can (i) effectively mitigate undesired solvated H 2 O-mediated side reactions on the Al anode; (ii) boost the de-solvation kinetics of Al 3+ while preventing cathode structural distortion; (iii) reduce the flammability of hybrid electrolytes. As a proof of concept, the Al//Al x MnO 2 full cell employing a hybrid electrolyte demonstrate enhanced stability (deliver 335 mAh g −1 while retaining 71 % capacity for 400 cycles) compared to those with pure electrolyte.}, archive = {J_ANGEW}, author = {Z. Zhao and Z. Zhang and W. Wang and T. Xu and X. Yu}, doi = {10.1002/anie.202415436}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415436}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strengthen water O−H bond in electrolytes for enhanced reversibility and safety in aqueous aluminum ion batteries}, volume = {64}, year = {2025}, }
• (2025). Oxygen plasma triggered Co−O−Fe motif in prussian blue analogue for efficient and robust alkaline water oxidation. ANGEW, 64(3), e202415423. (www)

  @article{ , abstract = {In the context of oxygen evolution reaction (OER), the construction of high-valence transition metal sites to trigger the lattice oxygen oxidation mechanism is considered crucial for overcoming the performance limitations of traditional adsorbate evolution mechanism. However, the dynamic evolution of lattice oxygen during the reaction poses significant challenges for the stability of high-valence metal sites, particularly in high-current-density water-splitting systems. Here, we have successfully constructed Co−O−Fe catalytic active motifs in cobalt-iron Prussian blue analogs (CoFe-PBA) through oxygen plasma bombardment, effectively activating lattice oxygen reactivity while sustaining robust stability. Our spectroscopic and theoretical studies reveal that the Co−O−Fe bridged motifs enable a unique double-exchange interaction between Co and Fe atoms, promoting the formation of high-valence Co species as OER active centers while maintaining Fe in a low-valence state, preventing its dissolution. The resultant catalyst (CoFe-PBA-30) requires an overpotential of only 276 mV to achieve 1000 mA cm −2 . Furthermore, the assembled alkaline exchange membrane electrolyzer using CoFe-PBA-30 as anode material achieves a high current density of 1 A cm −2 at 1.76 V and continuously operates for 250 hours with negligible degradation. This work provides significant insights for activating lattice oxygen redox without compromising structure stability in practical water electrolyzers.}, archive = {J_ANGEW}, author = {Hao Guan Xu and Chen Zhu and Hao Yang Lin and Ji Kai Liu and Yi Xiao Wu and Huai Qin Fu and Xin Yu Zhang and Fangxin Mao and Hai Yang Yuan and Chenghua Sun and Peng Fei Liu and Hua Gui Yang}, doi = {10.1002/anie.202415423}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415423}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen plasma triggered Co−O−Fe motif in prussian blue analogue for efficient and robust alkaline water oxidation}, volume = {64}, year = {2025}, }
• (2025). A direct chemical repair of etheno-type RNA damages. ANGEW, 64(3), e202415417. (www)

  @article{ , abstract = {Etheno damages in RNA represent a unique class of structural alterations that arise from exposure to various environmental stressors or endogenous processes. They significantly distort the RNA structure and affect crucial biological functions, including RNA-protein interactions, ribosome function, and translation fidelity. However, repair mechanisms for those etheno damages in RNA are still being elucidated. Here, a synthetic flavin derivative PS9 has been identified as the first example of chemical repair approach for this type of RNA damages. It efficiently managed the removal of etheno-type ϵA and ϵC damages in nucleosides, oligonucleotides in vitro , and in E. coli RNA in vivo under blue light irradiation. The capacity of the chemical approach relies on a unique cycloaddition activation of the etheno-bridge with singlet oxygen, which is distinct from traditional epoxidation of the C=C double bonds by proteins from the AlkB family. The understanding and effective manipulation of etheno damages in RNA with chemical tools hold implications for deciphering their role in mutagenesis and RNA biology, potentially opening avenues for targeted therapeutic interventions and biomarker development.}, archive = {J_ANGEW}, author = {Yin-Ming He and Alicia Burkard and Chuan-Shuo Wu and Xiao-Yang Jin and Li Liu and Mark Helm and Liang Cheng}, doi = {10.1002/anie.202415417}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415417}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A direct chemical repair of etheno-type RNA damages}, volume = {64}, year = {2025}, }
• (2025). Electrostatically dominated pre-organization in cyclodextrin Metal–Organic frameworks. ANGEW, 64(3), e202415404. (www)

  @article{ , abstract = {Electrostatic interactions between oppositely charged entities play a key role in pre-organizing substrates and stabilizing transition states of reactions in enzymes. The use of electrostatic interactions to pre-organize ions in nanoconfined pores, however, has not been investigated to its full potential. Herein, we describe how carboxylate anions can be pre-organized at the behest of their electrostatic interactions with K + cations in nanoconfined tunnels present in γ-cyclodextrin metal–organic frameworks, i.e., CD-MOFs. Several carboxylate anions, which are all much smaller than the cavities of the tunnels, were visualized by X-ray crystallography when nanoconfined in CD-MOFs, despite the large voids present in the tunnels. These anions were found to be aligned within a planar array defined by four K + cations, positioned around the periphery of the tunnels. The strong electrostatic interactions between the carboxylate anions and the K + cations dictate the orientation of the anions and override the influence of all other possible noncovalent bonding interactions between them and the tunnels. Consequently, the aligned pairs of γ-cyclodextrin rings constituting the tunnels become distorted, resulting in them having lower symmetry and fewer disordered carboxylate anions in the solid state. Our findings offer a transformative strategy for controlling the packing and orientation of ions in nanoconfined environments.}, archive = {J_ANGEW}, author = {Dengke Shen and Zhongyuan Zhang and Tanay Kesharwani and Huang Wu and Long Zhang and Charlotte L. Stern and Hongliang Chen and Qing-Hui Guo and Kang Cai and Aspen X.-Y. Chen and J. Fraser Stoddart}, doi = {10.1002/anie.202415404}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415404}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrostatically dominated pre-organization in cyclodextrin Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Clar's aromatic π-sextet rule for the construction of red multiple resonance emitter. ANGEW, 64(3), e202415400. (www)

  @article{ , abstract = {Despite the proliferation of multiple resonance (MR) materials in the blue to green spectral ranges, red MR emitters remain scarce in the literature, an area that certainly warrants attention for future applications. Here, through a clever application of classic Clar's aromatic π-sextet rule, we triumphantly constructed the first red MR emitter by substituting the conventional benzene ring core with anthracene (fewer π-sextets). Theoretical studies indicate that the quantity of π-sextets ultimately determines the optical band gap of a molecule, rather than the number of fused benzene rings. Benefiting from the high photoluminescence quantum yield of ~94 % and horizontal dipole ratio of ~90 %, the corresponding narrowband red (luminescence wavelength: 608 nm) organic light-emitting diode shows a high external quantum efficiency of 27.3 %, with only a slight decrease of 3.7 % at an elevated luminance level of 100,000 cd/m 2 .}, archive = {J_ANGEW}, author = {Haowen Chen and Mingxu Du and Cheng Qu and Qian Jin and Zequan Tao and Renjie Ji and Guimin Zhao and Tao Zhou and Yuheng Lou and Yueming Sun and Wei Jiang and Lian Duan and Yuewei Zhang}, doi = {10.1002/anie.202415400}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415400}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Clar's aromatic π-sextet rule for the construction of red multiple resonance emitter}, volume = {64}, year = {2025}, }
• (2025). Piperazine-derived bisphosphonate-based ionizable lipid nanoparticles enhance mRNA delivery to the bone microenvironment. ANGEW, 64(3), e202415389. (www)

  @article{ , abstract = {Nucleic acid delivery with mRNA lipid nanoparticles are being developed for targeting a wide array of tissues and cell types. However, targeted delivery to the bone microenvironment remains a significant challenge in the field, due in part to low local blood flow and poor interactions between drug carriers and bone material. Here we report bone-targeting ionizable lipids incorporating a piperazine backbone and bisphosphate moieties, which bind tightly with hydroxyapatite ([Ca 5 (PO 4 ) 3 OH]), a key component of mineralized tissues. These lipids demonstrate biocompatibility and low toxicity in both vitro and in vivo studies. LNP formulated with these lipids facilitated efficient cellular transfection and improved binding to hydroxyapatite in vitro, and targeted delivery to the bone microenvironment in vivo following systemic administration. Overall, our findings demonstrate the critical role of the piperazine backbone in a novel ionizable lipid, which incorporates a bisphosphonate group to enable efficient bone-targeted delivery, highlighting the potential of rational design of ionizable lipids for next-generation bone-targeting delivery systems.}, archive = {J_ANGEW}, author = {Il-Chul Yoon and Lulu Xue and Qinyuan Chen and Jingyi Liu and Junchao Xu and Zain Siddiqui and Dongyoon Kim and Bingling Chen and Qiangqiang Shi and Emily Laura Han and Mia Cherry Ruiz and Kyle H. Vining and Michael J. Mitchell}, doi = {10.1002/anie.202415389}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415389}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Piperazine-derived bisphosphonate-based ionizable lipid nanoparticles enhance mRNA delivery to the bone microenvironment}, volume = {64}, year = {2025}, }
• (2025). Solvent-dependent sequence-controlled copolymerization of lactones: Tailoring material properties from robust plastics to tough elastomers. ANGEW, 64(3), e202415388. (www)

  @article{ , abstract = {Copolymerization stands as a versatile and potent method for tailoring polymer properties by adjusting structural unit composition and sequence distribution. However, achieving sequence-controlled copolymerization in a one-step and one-pot process remains challenging. This study introduces a solvent-dependent sequence-controlled copolymerization strategy to produce block and statistical copolyesters from 4-phenyl-2-oxabicyclo[2.1.1]hexan-3-one (4 Ph -BL) and ϵ -caprolactone ( ϵ -CL). The distinct kinetics of the two monomers enable the facile synthesis of diblock and triblock copolyesters, PCL- b -P(4 Ph -BL) and P(4 Ph -BL)- b -PCL- b -P(4 Ph -BL), in non-coordinating solvents, such as dichloromethane and toluene. Conversely, coordinating solvents like tetrahydrofuran, 2-methyltetrahydrofuran, 2,5-dimethyltetrahydrofuran, 1,4-dioxane, and 1,2-dimethoxyethane facilitate frequent transesterifications, yielding statistical copolyesters P[CL- stat -(4 Ph -BL)] with varying ratios of heterosequences. Density functional theory (DFT) calculations confirmed that coordinating solvents stabilize the transition state for transesterification, thereby validating their role in triggering this process. By varying the microstructures and compositions, the resultant copolyesters display tunable thermal and mechanical properties, evolving from robust plastics with an ultimate tensile strength of up to 46.3±3.1 MPa to tough elastomers with >99.3 % elastic recovery. All the copolyesters exhibit remarkable thermal stability ( T d,5% =376 °C) and maintain desirable chemical circularity (>92 %), supporting a closed-loop life cycle for sustainable material economy.}, archive = {J_ANGEW}, author = {Chaoqun Weng and Xiao Li and Xiaoyan Tang}, doi = {10.1002/anie.202415388}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415388}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solvent-dependent sequence-controlled copolymerization of lactones: Tailoring material properties from robust plastics to tough elastomers}, volume = {64}, year = {2025}, }
• (2025). Robust and reversible Thermal/Electro-responsive supramolecular polymeric adhesives via synergistic hydrogen-bonds and ionic junctions. ANGEW, 64(3), e202415386. (www)

  @article{ , abstract = {Adhesive conducting elastomers are rising materials towards cutting-edge applications in wearable and implantable soft electronics. Yet, engineering the conductive adhesives with robust and tunable interfacial bonding strength is still in its infancy stage. We herein identify a structurally novel supramolecular polymer scaffold, characterized by synergistic coexistence of hydrogen-bonding (H−bonding) interactions and electrostatic ionic junctions, endowing the robust and tunable elastic conducting adhesives with remarkable thermal/electro-responsive performance. H−bonding association and electrostatic interaction play orthogonal yet synergistic roles in the strong supramolecular adhesive formation, serving as the leveraging forces for opposing both cohesion and adhesion energy. To do so, six-arm star-shaped random copolymers P1 , and P2 are strategically designed, bearing H−bonding PDAP (poly(diaminopyridine acrylamide)) and PThy (poly(thymine)) segments, which can form hetero-complementary DAP/Thy H−bonding association, along with ionic conductive poly(ionic liquid)s segment: PMBT, (poly(1-[2-methacryloylethyl]-3-methylimidazolium bis(trifluoromethane)-sulfonamide)). DAP/Thy H−bonding association, along with electrostatic ionic interaction, can yield dual supramolecular forces crosslinked polymeric networks with robust cohesion energy. Moreover, coexistence of poly(ionic liquid)s can impact and interfere the configuration of H−bonding association, liberate more free DAP and Thy motifs to form H−bonds towards substrate, affording strong surface adhesion in a synergistic manner. This work demonstrates a significant forward step towards potential adhesives devoted to hybrid electronic devices.}, archive = {J_ANGEW}, author = {Qizhe Deng and Shengli Han and Yanggui Wu and Yiwen Chen and Yinhua Zhang and Yonggang Zhao and Senbin Chen and Jintao Zhu}, doi = {10.1002/anie.202415386}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415386}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust and reversible Thermal/Electro-responsive supramolecular polymeric adhesives via synergistic hydrogen-bonds and ionic junctions}, volume = {64}, year = {2025}, }
• (2025). Towards efficient white-light emission in sulfur dots through surface charge engineering. ANGEW, 64(3), e202415383. (www)

  @article{ , abstract = {Sulfur dots (SDs) have emerged as promising photoluminescence (PL) materials owing to their intrinsic merits such as abundant electronic effects, outstanding biocompatibility and available photocatalytic activity. Typically based on quantum confinement effects, SDs are reported usually confined emission in blue-to-green region. However, it is challenging to achieve their broad emission tunability in the visible region, restricted by inherent band gap of bulk sulfur (ca. 2.79 eV). Herein, we present white-light-emitting SDs achieved by surface charge engineering that hybridizes the surface of SDs with oleylamine. The resulting SDs exhibit broadband emissions (full width at half maximum of 187 nm) with PL quantum yields of up to 12.1 % and Commission International de I'Eclairage color coordinates of (0.27, 0.32). Detailed experimental and theoretical analysis reveal that the strong orbital coupling between oleylamine and sulfur on the hybrid surfaces of the SDs causes electron delocalization, leading to the generation of low-energy charge transfer (CT) states. These CT states are highly sensitive to sulfur-oleylamine hybrid structures, which complicate the transition dynamics and promote multi-energy emissions, accounting for efficient white-light emission. The demonstration of white-light SDs based on surface charge engineering is an important step towards the development of sulfur-based PL materials.}, archive = {J_ANGEW}, author = {Weibin Wang and Yixuan Wang and Kaixiang Jin and Xinyi Yang and Yongming Sui and Bo Zou}, doi = {10.1002/anie.202415383}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards efficient white-light emission in sulfur dots through surface charge engineering}, volume = {64}, year = {2025}, }
• (2025). A redox-active cyclometalated platinum ring enables synthetic post-processing of a [2]Rotaxane. ANGEW, 64(3), e202415381. (www)

  @article{ , abstract = {Post-synthetic modification of mechanically interlocked molecules (MIMs) is an attractive avenue to add complexity to already intricate systems. This remains an important, challenging topic that is under-developed. In this paper, we report the synthesis and characterization of a [2]rotaxane molecule featuring a ring appended to an emissive cyclometalated Pt II unit. Modulation of the oxidation state at the metal center can transform the interlocked molecule into a new Pt IV [2]rotaxane or a Pt III [3]rotaxane held together by an intermetallic Pt−Pt bond – a first of its kind. These molecules display distinct structural and photophysical properties, as well as shuttling dynamics. This approach for post-synthetic modification could be used to construct more complex MIMs and inorganic supramolecular assemblies with redox properties.}, archive = {J_ANGEW}, author = {Raksha Kandel and Miguel A. Soto and Daniel Medina and Brian O. Patrick and Francesco Lelj and Mark J. MacLachlan}, doi = {10.1002/anie.202415381}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415381}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A redox-active cyclometalated platinum ring enables synthetic post-processing of a [2]Rotaxane}, volume = {64}, year = {2025}, }
• (2025). Strong magneto-chiroptical effects through introducing chiral transition-metal complex cations to lead halide. ANGEW, 64(3), e202415363. (www)

  @article{ , abstract = {The interplay between chirality with magnetism can break both the space and time inversion symmetry and have wide applications in information storage, photodetectors, multiferroics and spintronics. Herein, we report the chiral transition-metal complex cation-based lead halide, R -CDPB and S -CDPB. In contrast with the traditional chiral metal halides with organic cations, a novel strategy for chirality transfer from the transition-metal complex cation to the lead halide framework is developed. The chiral complex cations directly participate the band structure and introduce the d - d transitions and tunable magneto-chiroptical effects in both the ultraviolet and full visible range into R -CDPB and S -CDPB. Most importantly, the coupling between magnetic moment of the complex cation and chiroptical properties is confirmed by the magneto-chiral dichroism. For the band-edge transition, the unprecedented modulation of +514 % for S -CDPB and −474 % for R -CDPB was achieved at −1.3 Tesla. Our findings demonstrate a novel strategy to combine chirality with magnetic moment, and provide a versatile material platform towards magneto-chiroptical and chiro-spintronic applications.}, archive = {J_ANGEW}, author = {Haolin Lu and Fenglian Qi and Hebin Wang and Tengfei He and Bing Sun and Xiaoqing Gao and Andrew H. Comstock and Sehrish Gull and Yunxin Zhang and Tianjiao Qiao and Tianyin Shao and You-Xuan Zheng and Dali Sun and Yongsheng Chen and Hao-Li Zhang and Zhiyong Tang and Guankui Long}, doi = {10.1002/anie.202415363}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415363}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strong magneto-chiroptical effects through introducing chiral transition-metal complex cations to lead halide}, volume = {64}, year = {2025}, }
• (2025). Versatile mechanochemical reactions via tailored force transmission in mechanophores. ANGEW, 64(3), e202415353. (www)

  @article{ , abstract = {In polymer mechanochemistry, regulating the intrinsic mechanical reactivity of a mechanophore offers extensive opportunities in material science, enabling the development of hierarchical and multifunctional polymer-based materials. Recent advances have focused on innovating various types of mechanophores with inherent reactivity (e.g. regioselectivity and stereoselectivity). However, little attention has been given to modulating their reactivity by tailoring force transmission within mechanophores. Here, we introduce a novel approach through the implementation of a cyclic pulling geometry into an anthracene-maleimide (AM) mechanophore. This approach manipulates force transmission within the mechanophore and effectively regulates its reactivity from 0.0160 min −1 to 0.00133 min −1 , achieving up to a 12-fold change. Mechanochemical coupling analysis indicates that the split force transmission along ring chains contributes to the significant difference in mechanochemical reactivity. By leveraging the distinct force transmission pathways within cyclic and linear AM mechanophores, we covalently integrate them with a spiropyran mechanophore to design tandem mechanophore systems for hierarchical mechanochemical activation. These findings highlight the efficacy and versatility of the cyclic pulling strategy in modulating mechanophore reactivity, providing valuable insights for the design of tunable multifunctional polymer-based materials.}, archive = {J_ANGEW}, author = {Deao Xu and Wenjie Liu and Shijia Tian and Hai Qian}, doi = {10.1002/anie.202415353}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415353}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Versatile mechanochemical reactions via tailored force transmission in mechanophores}, volume = {64}, year = {2025}, }
• (2025). Highly conductive alcohol-processable n-type conducting polymer enabled by finely tuned electrostatic interactions for green organic electronics. ANGEW, 64(3), e202415349. (www)

  @article{ , abstract = {Solution-processable conducting polymers open up a new era in organic electronics, fundamentally altering the processing methods of electronic devices. P-type conducting polymers, exemplified by aqueous solution-processed poly(3,4-ethylenedioxythiophene) : poly(styrenesulfonate) (PEDOT : PSS), have been successfully commercialized. However, the performance of electron-transporting (n-type) materials remains considerably poorer. One of the primary challenges lies in striking a balance between conductivity and solvent processability. At present, most n-type conducting polymers necessitate toxic solvents for processing, which contradicts environmentally sustainable principles and impedes their potential for large-scale industrial applications. Herein, we developed an alcohol-processable high-performance n-type conducting polymer, poly(3,7-dihydrobenzo[1,2-b : 4,5-b’]difuran-2,6-dione): poly(2-ethyl-2-oxazoline) (PBFDO : PEOx), which utilized electrostatic interactions between PEOx and PBFDO to simultaneously achieve high conductivity and alcohol-processability. The PBFDO : PEOx films exhibited remarkable electrical conductivity exceeding 1000 S cm −1 with outstanding stability even at temperatures up to 250 °C, establishing it as a prominent green solvent-processed n-type conducting polymer that rivals the most advanced p-type counterparts. Various applications including organic thermoelectric, electrochemical transistor, and electrochromic devices were showcased, highlighting the broad potential of PBFDO : PEOx in advancing green organic electronics.}, archive = {J_ANGEW}, author = {Haoran Tang and Zishuo Xu and Yuanying Liang and Wei Cui and Yiheng Chen and Qinglin Jiang and Ting Lei and Yuguang Ma and Fei Huang}, doi = {10.1002/anie.202415349}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415349}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly conductive alcohol-processable n-type conducting polymer enabled by finely tuned electrostatic interactions for green organic electronics}, volume = {64}, year = {2025}, }
• (2025). A noncovalent π-stacked dual-pore molecular crystal for Ethanol/Water and Benzene/Methanol azeotrope separation. ANGEW, 64(3), e202415346. (www)

  @article{ , abstract = {Separation of ethanol/water or benzene/methanol azeotrope mixtures presents significant challenges, not only due to the limitations of conventional distillation techniques but also because of the constraints in developing and utilizing of new generation adsorbents. Porous organic molecular frameworks constructed via noncovalent π-interactions are emerging as novel adsorbents with vast potential in gas adsorption and molecular separation. Herein, we report a permanent two-dimensional porous structure, namely TDTBA-1 , which consists of two different kinds of pores through π-stacking of a single organic molecule with highly T d symmetry. Activated TDTBA-1 exhibits excellent hydrophobicity, thermal stability, recoverability and high selectivity for ethanol over water, and benzene over methanol. Therefore, activated TDTBA-1 can be used as an efficient stationary phase for the separation of ethanol/water and benzene/methanol azeotropes by high-resolution gas chromatography.}, archive = {J_ANGEW}, author = {Xiang Meng and Shuixiang Zou and Jiawei Li and Cheng Chen and Jie Zhang and Mingyan Wu}, doi = {10.1002/anie.202415346}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415346}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A noncovalent π-stacked dual-pore molecular crystal for Ethanol/Water and Benzene/Methanol azeotrope separation}, volume = {64}, year = {2025}, }
• (2025). Unlocking mechanism of anion and cation interaction on ion conduction of polymer based electrolyte in metal batteries. ANGEW, 64(3), e202415343. (www)

  @article{ , abstract = {Polymer based electrolyte shows advantages in compatibly improving safety and interface stability of batteries, while its limited ion conductivity and transfer number make it difficult to apply in batteries with high energy density. Herein, by designing four crosslinking polyesters with different electron withdrawing group (EWG), it is found that strengthening the binding of EWG to anion for weakening the binding of anion to Li + is critical for high Li + transfer number ( ) and ionic conductivity of electrolyte. As a result, poly (2,2,3,3-tetrafluoropropyl methacrylate) (PTFM) based gel polymer electrolyte (GPE) shows an ionic conductivity of 0.78 mS cm −1 and a of 0.85, much higher than those of poly (methyl methacrylate) (PMMA) without EWG. Moreover, PTFM based GPE shows excellent flame retardancy property. Li||PTFM||NCM811 batteries with an ultrahigh capacity of 5.5 mAh cm −2 show stable cycles of 5 times to that of Li||PMMA||NCM811. Moreover, the assembled graphite||PTFM||NCM811 pouch cell shows a capacity retention rate of 92 % after 500 cycles. This work clarifies the mechanism of cation/anion interaction on ionic conductivity of GPE, which is important to develop high-performance devices with good safety and flexibility.}, archive = {J_ANGEW}, author = {Qi Zhang and Tengfei Bian and Xiaobing Wang and Ruijuan Shi and Yong Zhao}, doi = {10.1002/anie.202415343}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415343}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unlocking mechanism of anion and cation interaction on ion conduction of polymer based electrolyte in metal batteries}, volume = {64}, year = {2025}, }
• (2025). Dipole moment modulation of terminal groups enables asymmetric acceptors featuring medium bandgap for efficient and stable ternary organic solar cells. ANGEW, 64(3), e202415332. (www)

  @article{ , abstract = {This study puts forth a novel terminal group design to develop medium-band gap Y-series acceptors beyond conventional side-chain engineering. We focused on the strategical integration of an electron-donating methoxy group and an electron-withdrawing halogen atom at benzene-fused terminal groups. This combination precisely modulated the dipole moment and electron density of terminal groups, effectively attenuating intramolecular charge transfer effect, and widening the band gap of acceptors. The incorporation of these terminal groups yielded two asymmetric acceptors, named BTP-2FClO and BTP-2FBrO, both of which exhibited open-circuit voltage ( V oc ) as high as 0.96 V in binary devices, representing the highest V OC s among the asymmetric Y-series small molecule acceptors. More importantly, both BTP-2FClO and BTP-2FBrO exhibit modest aggregation behaviors and molecular crystallinity, making them suitable as a third component to mitigate excess aggregation of the PM6 : BTP-eC9 blend and optimize the devices’ morphology. As a result, the optimized BTP-2FClO-based ternary organic solar cells (OSCs) achieved a remarkable power conversion efficiency (PCE) of 19.34 %, positioning it among the highest-performing OSCs. Our study highlights the molecular design importance on manipulating dipole moments and electron density in developing medium-band gap acceptors, and offers a highly efficient third component for high-performance ternary OSCs.}, archive = {J_ANGEW}, author = {Bosen Zou and Anhai Liang and Pengbo Ding and Jia Yao and Xianghao Zeng and Hongxiang Li and Ruijie Ma and Chunliang Li and Weiwei Wu and Dezhang Chen and Memoona Qammar and Han Yu and Jicheng Yi and Liang Guo and Sai Ho Pun and Jonathan E. Halpert and Gang Li and Zhipeng Kan and He Yan}, doi = {10.1002/anie.202415332}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415332}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dipole moment modulation of terminal groups enables asymmetric acceptors featuring medium bandgap for efficient and stable ternary organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Rational design of crystalline and enantiomerically pure helicenes with open-shell singlet ground states. ANGEW, 64(3), e202415331. (www)

  @article{ , abstract = {Helicene diradical derivatives have attracted widespread attentions because of their unique magnetic and chiroptoelectronic properties, however, crystalline and enantiomerically pure forms of helicene diradicals are extremely rare. Herein, we describe the rational design and synthesis of o -quinone functionalized helicene diradicals with crystalline enantiomerical purity. Diradical dianion salt Rac - 3K and its enantiomers P / M - 3K were obtained by reduction of corresponding precursors Rac - 3 and P / M - 3 with two equivalent potassium graphite in THF in the presence of (di)benzo-18-crown-6. Neutral dioxoborocyclic helicene diradicals ( Rac - 3B and P / M - 3B ) were produced by reactions of Rac - 3 or P / M - 3 with chlorobis(perfluorophenyl)borane (B(C 6 F 5 ) 2 Cl. Crystal structures of compounds Rac - 3K , Rac - 3B and P / M - 3K were obtained by single crystal X-ray diffraction. Their open-shell singlet state ground states were confirmed by electron paramagnetic resonance (EPR) spectroscopy, superconducting quantum interference device (SQUID) measurements and theoretical calculations. Their chiroptical properties were investigated by the electronic circular dichroism (ECD) spectroscopy. This work provides the first examples of enantiopure helicene diradical dianions and boron-containing helicene diradicals.}, archive = {J_ANGEW}, author = {Tao Wang and Shuxuan Tang and Xue Dong and Yu Zhao and Quanchun Sun and Shanshan Kong and Yue Zhao and Xinping Wang}, doi = {10.1002/anie.202415331}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415331}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design of crystalline and enantiomerically pure helicenes with open-shell singlet ground states}, volume = {64}, year = {2025}, }
• (2025). MicroRNA-triggered programmable DNA-encoded pre-PROTACs for cell-selective and controlled protein degradation. ANGEW, 64(3), e202415323. (www)

  @article{ , abstract = {Proteolysis-targeting chimeras (PROTACs) have accelerated drug development; however, some challenges still exist owing to their lack of tumor selectivity and on-demand protein degradation. Here, we developed a miR NA- i nitiated a ssembled pre-PRO TAC (miRiaTAC) platform that enables the on-demand activation and termination of target degradation in a cell type-specific manner. Using miRNA-21 as a model, we engineered DNA hairpins labeled with JQ-1 and pomalidomide and facilitated the modular assembly of DNA-encoded pre-PROTACs through a hybridization chain reaction. This configuration promoted the selective polyubiquitination and degradation of BRD4 upon miR-21 initiation, highlighting significant tumor selectivity and minimal systemic toxicity. Furthermore, the platform incorporates photolabile groups, enabling the precise optical control of pre-PROTACs during DNA assembly/disassembly, mitigating the risk of excessive protein degradation. Additionally, by introducing a secondary ligand targeting CDK6, these pre-PROTACs were used as a modular scaffold for the programmable assembly of active miRiaTACs containing two different warheads in exact stoichiometry, enabling orthogonal multitarget degradation. The integration of near-infrared light-mediated photodynamic therapy through an upconversion nanosystem further enhanced the efficacy of the platform with potent in vivo anticancer activity. We anticipate that miRiaTAC represents a significant intersection between dynamic DNA nanotechnology and PROTAC, potentially expanding the versatility of PROTAC toolkit for cancer therapy.}, archive = {J_ANGEW}, author = {Jiayin Zhan and Xiang Li and Zhe Feng and Zheng Liu and Zhiyuan Feng and Jun-Jie Zhu and Jingjing Zhang}, doi = {10.1002/anie.202415323}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415323}, shortjournal = {Angew. Chem. Int. Edit.}, title = {MicroRNA-triggered programmable DNA-encoded pre-PROTACs for cell-selective and controlled protein degradation}, volume = {64}, year = {2025}, }
• (2025). LiLnGeS4 (Ln=La−Nd): Designing high performance infrared nonlinear optical sulfides through “Band reformation of AGS”. ANGEW, 64(3), e202415318. (www)

  @article{ , abstract = {AgGaS 2 (AGS) is the most commonly used commercial infrared nonlinear optical (IR NLO) material. However, AGS has a narrow band gap ( E g =2.58 eV) and a low laser-induced damage threshold (LIDT), primarily attributed to its mobile liquid-like Ag + constituent and the unstable Ag−S chemical bond. Herein, we propose a “band reformation of AGS” strategy, which leads to the successful syntheses of four lanthanide sulfides, LiLnGeS 4 (Ln=La−Nd), crystalizing in an asymmetric Ama 2 structure. LiLaGeS 4 demonstrates that eliminating the presence of Ag-4 d band increases the E g to 3.32 eV and enhances the LIDT (14–29×AGS, measured by both powder and single crystal); while increasing the nonbonding density of states of the S-3 p band enhances the 2 nd -nonlinear optical coefficient (1.06×AGS). Besides, the bond length discrepancy between [LiS 4 ], [GeS 4 ] and [LaS 8 ] units leads to a moderate birefringence (Δ n =0.052). Such a unique structure further results in extremely small thermal expansion with α L =0.41–1.74×10 −5 K −1 , along different crystallographic axes. Our theoretical studies indicate that the synergy of the structure building units contribute to the second harmonic generation performance. These results suggest that the “band reformation of AGS” strategy provides effective guidance to discover new NLO crystals with optimized performance.}, archive = {J_ANGEW}, author = {Qian-Qian Liu and Xin Liu and Mei-Ze Li and Rui-Xi Wang and Bingxuan Li and Li-Ming Wu and Ling Chen}, doi = {10.1002/anie.202415318}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415318}, shortjournal = {Angew. Chem. Int. Edit.}, title = {LiLnGeS4 (Ln=La−Nd): Designing high performance infrared nonlinear optical sulfides through “Band reformation of AGS”}, volume = {64}, year = {2025}, }
• (2025). Copper-catalyzed enantioselective hydrophosphorylation of unactivated alkynes. ANGEW, 64(3), e202415314. (www)

  @article{ , abstract = {P-stereogenic phosphorus compounds are essential across various fields, yet their synthesis via enantioselective P−C bond formation remains both challenging and underdeveloped. We report the first copper-catalyzed enantioselective hydrophosphorylation of alkynes, facilitated by a newly designed chiral 1,2-diamine ligand. Unlike previous methods that rely on kinetic resolution with less than 50 % conversion, our approach employs a distinct dynamic kinetic asymmetric transformation mechanism, achieving complete conversion of racemic starting materials. This reaction is compatible with a broad range of aromatic and aliphatic terminal alkynes, producing products with high yields (up to 95 %), exclusive cis selectivity, and exceptional regio- and enantioselectivity (>20 : 1 r.r. and up to 96 % ee). The resulting products were further transformed into a diverse array of enantioenriched P-stereogenic scaffolds. Preliminary mechanistic studies were conducted to elucidate the reaction details.}, archive = {J_ANGEW}, author = {Jie Kang and Kang Ding and Si-Mu Ren and Wen-Jun Yang and Bo Su}, doi = {10.1002/anie.202415314}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper-catalyzed enantioselective hydrophosphorylation of unactivated alkynes}, volume = {64}, year = {2025}, }
• (2025). Oxygen-doped carbon nitrides with visible room-temperature phosphorescence and invisible thermal-stimuli-responsive ultraviolet delayed fluorescence for security applications. ANGEW, 64(3), e202415312. (www)

  @article{ , abstract = {Multi-mode emissive materials with stimuli-responsive producing invisible signals are very attractive for advanced security applications, but development of such materials remains highly challenging. In this work, oxygen-doped carbon nitrides (O-CNs) are prepared via microwave-assisted heating of urea, which exhibit ultraviolet (UV) solid-state fluorescence (SSFL), visible room temperature phosphorescence (RTP) and thermal-stimuli production of invisible UV delayed fluorescence (DF) properties. Further studies confirmed that the SSFL and RTP could be attributed to the introduction of oxygen functional group (e. g., C=O) in the skeleton of O-CNs, thus minimizing the aggregation caused quenching effect, facilitating intersystem crossing, and stabilizing the excited triplet states. The specific thermal-stimuli production of UV DF is deemed to be the relatively large energy gap between ground and excited singlet states as well as an effective triplet-triplet annihilation. Notably, the emission maximum of UV DF locates at ~310 nm with an ultra-narrow full width at half maximum (FWHM) down to 19 nm, so it is completely invisible to the naked eyes, but detectable by a UV camera. To employ the unique characteristics of O-CNs, security protection strategies with superior concealment by virtue of the thermal-stimuli quenching visible RTP and meanwhile producing invisible UV DF are demonstrated.}, archive = {J_ANGEW}, author = {Xinyuan Tong and Yongjian Wu and Kai Jiang and Jun Jiang and Yixuan Xu and Linger Feng and Xiaomeng Wang and Jiaren Du and Hengwei Lin}, doi = {10.1002/anie.202415312}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415312}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen-doped carbon nitrides with visible room-temperature phosphorescence and invisible thermal-stimuli-responsive ultraviolet delayed fluorescence for security applications}, volume = {64}, year = {2025}, }
• (2025). Importing atomic rare-earth sites to activate lattice oxygen of spinel oxides for electrocatalytic oxygen evolution. ANGEW, 64(3), e202415306. (www)

  @article{ , abstract = {Spinel oxides have emerged as highly active catalysts for the oxygen evolution reaction (OER). Owing to covalency competition, the OER process on spinel oxides often follows an arduous adsorbate evolution mechanism (AEM) pathway. Herein, we propose a novel rare-earth sites substitution strategy to tune the lattice oxygen redox of spinel oxides and bypass the AEM scaling relationship limitation. Taking NiCo 2 O 4 as a model, the incorporation of Ce into the octahedral site induces the formation of Ce−O−M (M=Ni, Co) bridge, which triggers charge redistribution within NiCo 2 O 4 . The developed Ce−NiCo 2 O 4 exhibits remarkable OER activity with a low overpotential, satisfactory electrochemical stability, and good practicability in anion-exchange membrane water electrolyzer. Theoretical analyses reveal that OER on Ce−NiCo 2 O 4 surface follows a more favorable lattice oxygen mechanism (LOM) pathway and non-concerted proton-electron transfers compared to pure NiCo 2 O 4 , as also verified by pH-dependent behavior and in situ Raman analysis. The 18 O-labeled electrochemical mass spectrometry provides direct evidence that the oxygen released during the OER originates from the lattice oxygen of Ce−NiCo 2 O 4 . We discover that electron delocalization of Ce 4 f states triggers charge redistribution in NiCo 2 O 4 through the Ce−O−M bridge, favoring antibonding state occupation of Ni−O bonding in [Ce−O−Ni] unit site, thereby activating lattice oxygen redox of NiCo 2 O 4 in OER. This work provides a new perspective for designing highly active spinel oxides for OER and offers significant insights into the rare-earth-enhanced LOM mechanism.}, archive = {J_ANGEW}, author = {Xuan Wang and Jinrui Hu and Tingyu Lu and Huiyu Wang and Dongmei Sun and Yawen Tang and Hao Li and Gengtao Fu}, doi = {10.1002/anie.202415306}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415306}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Importing atomic rare-earth sites to activate lattice oxygen of spinel oxides for electrocatalytic oxygen evolution}, volume = {64}, year = {2025}, }
• (2025). “Boron ylide” enables stereoselective construction of gem-diborylcyclopropanes. ANGEW, 64(3), e202415301. (www)

  @article{ , abstract = {The stereoselective cyclopropanation of olefins with “boron ylide” is disclosed for the first time, providing a modular strategy for the synthesis of stereospecific diboryl-functionalized cyclopropanes. The chiral gem -diborylcyclopropanes are synthesized with excellent enantioselectivity with the aid of a chiral auxiliary. Based on the powerful transformable ability of boryl group, those challenging multi-quaternary carbon centers in cyclopropane units have been facilely constructed with excellent stereoselectivity. Control experiments indicate that the boryl groups are necessary for both chemoselectivity and stereoselectivity control.}, archive = {J_ANGEW}, author = {Tongchang Fang and Peng Zhang and Chao Liu}, doi = {10.1002/anie.202415301}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415301}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“Boron ylide” enables stereoselective construction of gem-diborylcyclopropanes}, volume = {64}, year = {2025}, }
• (2025). Triple regulations via fe redox boosting nitrate reduction to ammonia at industrial current densities. ANGEW, 64(3), e202415300. (www)

  @article{ , abstract = {Electrochemical nitrate reduction reaction (NO 3 − RR) has promising prospects for green synthesis of ammonia and environmental remediation. However, the performance of catalysts at high current density usually suffers from the high energy barrier for the nitrate (NO 3 − ) to nitrite (NO 2 − ) and the competitive hydrogen evolution. Herein, we proposed a two-step relay mechanism through spontaneous redox reaction followed electrochemical reaction by introducing low-valence Fe species into Ni 2 P nanosheets to significantly enhance the NO 3 − RR performance at industrial current density. The existence of low-valence Fe species bypasses the NO 3 − to NO 2 − step through the spontaneous redox with NO 3 − to produce NO 2 − and Fe 2 O 3 , regulates the electronic structure of Ni 2 P to reduce the barrier of NO 2 − to NH 3 , thirdly prohibits the hydrogen evolution by consuming the excess active hydrogen through reduction of Fe 2 O 3 to recover low-valence Fe species. The triple regulations via Fe redox during the two-step relay reactions guarantee the Fe-Ni 2 P@NF high ammonia yield of 120.1 mg h −1 cm −2 with Faraday efficiency of more than 90% over a wide potential window and a long-term stability of more than 130 h at ~1000 mA cm −2 . This work provides a new strategy to realize the design and synthesis of nitrate reduction electrocatalysts at high current densities.}, archive = {J_ANGEW}, author = {Wenhao Yang and Ziwei Chang and Xu Yu and Ruxiang Shen and Lianzhou Wang and Xiangzhi Cui and Jianlin Shi}, doi = {10.1002/anie.202415300}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415300}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triple regulations via fe redox boosting nitrate reduction to ammonia at industrial current densities}, volume = {64}, year = {2025}, }
• (2025). Improving the selectivity and stability of supported cobalt catalysts via static bi-doping and dynamic trace CO2 co-feeding during propane dehydrogenation. ANGEW, 64(3), e202415295. (www)

  @article{ , abstract = {Simultaneously enhancing selectivity and stability on supported propane dehydrogenation (PDH) catalysts remains a formidable challenge. Here, we report a combined static and dynamic strategy to address these issues synergistically. Firstly, we demonstrate a feasible sol-gel method for preparing atomically-dispersed Bi-decorated metal nanoparticle catalysts (MBi/Al 2 O 3 , M=Fe, Co, Ni, and Zn). In PDH testing, the total selectivity of by-products (CH 4 and C 2 H 6 ) significantly decreases to 4 % for CoBi catalysts due to the static Bi-doping, compared with 16 % for Co-supported catalysts. Secondly, to enhance catalytic stability, we introduce a dynamic trace CO 2 co-feeding route. 10CoBi/Al 2 O 3 catalysts exhibit superior durability against coke formation for 330 hours in PDH under a 40 % C 3 H 8 atmosphere followed by pure C 3 H 8 conditions at 600 °C while maintaining propylene selectivity at 96 %. Notably, introducing trace CO 2 leads to a remarkable 6-fold decrease in the deactivation rate constant ( k d ). Multiple characterizations and density functional theory calculations reveal that charge transfer from atomically-distributed Bi to Co nanoparticles benefits lowering the energy of C 3 H 6 adsorption thereby suppressing by-products. Furthermore, the dynamic co-feeding of trace CO 2 facilitates coke removal, suppressing catalyst deactivation. The static Bi-doping and dynamic trace CO 2 co-feeding strategy contributes simultaneously to increased selectivity and stability on supported PDH catalysts.}, archive = {J_ANGEW}, author = {Yongbin Yao and Jingnan Wang and Qiang Liu and Can Yu and Zhan Gao and Fangli Yuan and Xi Wang}, doi = {10.1002/anie.202415295}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415295}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving the selectivity and stability of supported cobalt catalysts via static bi-doping and dynamic trace CO2 co-feeding during propane dehydrogenation}, volume = {64}, year = {2025}, }
• (2025). Simultaneous regulation of organic and inorganic components in interphase by fiber separator for high-stable sodium metal batteries. ANGEW, 64(3), e202415283. (www)

  @article{ , abstract = {Uncontrollable side reactions at the metal interface have been identified as the root cause of the formation of a fragile solid electrolyte interphase, leading to irreversible sodium loss in sodium metal batteries. Here, we proposed an interface engineering strategy that employed a carboxyl functionalized cellulose separator to provide strong dipole moments and induce the cleavage of P−F bond to construct a solid electrolyte interphase (SEI) rich in NaF. In addition, we employed nuclear magnetic resonance technology confirmed that the separator with strong dipole moments prevented the reduction of organic solvents by attracting electrons, thereby inhibiting the formation of organic oligomers. SEI with high NaF content and few oligomers is smooth and robust, obviously decreasing the interface impedance of the Na anode. The symmetric Na||Na cells, equipped with the functionalized separator, efficiently operated for 1400 hours with a stable 72 mV overpotential at 0.25 mA cm −2 , exhibiting low energy barrier and fast ion transport kinetics. The Na||Na 3 V 2 (PO 4 ) 3 cell also showed stable cycling performance, with the capacity remaining at 94.83 % of the initial capacity after 1000 cycles at 1C. The proposed separator could control the formation and composition of SEI, paving the way for the development of long-life sodium metal batteries.}, archive = {J_ANGEW}, author = {Zhixin Xue and Tao Zhang and Xiao Li and Fei Wang and Guiyin Xu and Meifang Zhu}, doi = {10.1002/anie.202415283}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415283}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous regulation of organic and inorganic components in interphase by fiber separator for high-stable sodium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Prompting CO2 electroreduction to ethanol by iron group metal ion dopants induced multi-sites at the interface of SnSe/SnSe2 p–n heterojunction. ANGEW, 64(3), e202415273. (www)

  @article{ , abstract = {The development of non-copper-based materials for CO 2 electroreduction to ethanol with high selectivity at large current density is highly desirable, but still a great challenge. Herein, we report iron group metal ions of M 2+ (M=Fe, Co, or Ni)-doped amorphous/crystalline SnSe/SnSe 2 nanorod/nanosheet hierarchical structures (a/c-SnSe/SnSe 2 ) for selective CO 2 electroreduction to ethanol. Iron group metal ions doping induces multiple active sites at the interface of M 2+ -doped SnSe/SnSe 2 p-n heterojunction, which strengthens *CO intermediate binding for further C−C coupling to eventual ethanol generation. As a representative, Fe 9.0% -a/c-SnSe/SnSe 2 exhibits an ethanol Faradaic efficiency of 62.7 % and a partial current density of 239.0 mA cm −2 at −0.6 V in a flow cell. Moreover, it can output an ethanol Faradaic efficiency of 63.5 % and a partial current density of 201.2 mA cm −2 with a full-cell energy efficiency of 24.1 % at 3.0 V in a membrane electrode assembly (MEA) electrolyzer. This work provides insight into non-Cu based catalyst design for stabilizing the key intermediates for selective ethanol production from CO 2 electroreduction.}, archive = {J_ANGEW}, author = {Xinyue Zheng and Yan Hu and Xiangyu Wang and Jiahui Zhu and Xingyue Zhang and Tian Sheng and Zhengcui Wu}, doi = {10.1002/anie.202415273}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415273}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Prompting CO2 electroreduction to ethanol by iron group metal ion dopants induced multi-sites at the interface of SnSe/SnSe2 p–n heterojunction}, volume = {64}, year = {2025}, }
• (2025). Self-assembled antibody-oligonucleotide conjugates for targeted delivery of complementary antisense oligonucleotides. ANGEW, 64(3), e202415272. (www)

  @article{ , abstract = {Antibody-oligonucleotide conjugate (AOC) affords preferential cell targeting and enhanced cellular uptake of antisense oligonucleotide (ASO). Here, we have developed a modular AOC (MAOC) approach based on accurate self-assembly of separately prepared antibody and ASO modules. Homogeneous multimeric AOC with defined ASO-to-antibody ratio were generated by L–DNA scaffold mediated precise self-assembly of antibodies and ASOs. The MAOC approach has been implemented to deliver exon skipping ASOs via transferrin receptor (TfR1) mediated internalization. We discovered an anti-TfR1 sdAb that can greatly enhance nuclear delivery of ASOs. Cryo-EM structure of the sdAb-TfR1 complex showed a new epitope that does not overlap with the binding sites of endogenous TfR1 ligands. In vivo functional analyses of MAOCs with one ASO for single exon skipping and two ASOs for double exon skipping showed that both ASO concentration and exon skipping efficacy of MAOC in cardiac and skeletal muscles are dramatically higher than conventional ASOs in the transgenic human TfR1 mouse model. MAOC treatment was well tolerated in vivo and not associated with any toxicity-related morbidity or mortality. Collectively, our data suggest that the self-assembled MAOC is a viable option for broadening the therapeutic application of ASO via multi-specific targeting and delivery.}, archive = {J_ANGEW}, author = {Liujuan Zhou and Jie Bi and Shenghai Chang and Zhaoshuai Bai and Junqi Yu and Ruru Wang and Zhihang Li and Xing Zhang and James J. Chou and Liqiang Pan}, doi = {10.1002/anie.202415272}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415272}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled antibody-oligonucleotide conjugates for targeted delivery of complementary antisense oligonucleotides}, volume = {64}, year = {2025}, }
• (2025). Bimetallic Cu11Ag3 nanotips for ultrahigh yield rate of nitrate-to-ammonium. ANGEW, 64(3), e202415259. (www)

  @article{ , abstract = {Electrochemical reduction of nitrate to ammonia (NRA) offers a sustainable approach for NH 3 production and NO 3 − removal but suffers from low NH 3 yield rate (<1.20 mmol h −1 cm −2 ). We present bimetallic Cu 11 Ag 3 nanotips with tailored local environment, which achieve an ultrahigh NH 3 yield rate of 2.36 mmol h −1 cm −2 at a low applied potential of −0.33 V vs. RHE, a high Faradaic efficiency (FE) of 98.8 %, and long-term operation stability at 1800 mg-N L −1 NO 3 − , outperforming most of the recently reported catalysts. At a NO 3 − concentration as low as 15 mg-N L −1 , it still delivers a high FE of 86.9 % and an NH 3 selectivity of 93.8 %. Finite-element method and density functional theory calculations reveal that the Cu 11 Ag 3 exhibits reduced adsorption energy barrier of *N intermediates, favorable water dissociation for *H generation and high energy barrier for H 2 formation, while its tip-enhanced enrichment promoting NO 3 − accumulation.}, archive = {J_ANGEW}, author = {Changhong Wang and Zhengyang Liu and Quanxiao Peng and Dandan Xing and Tao Hu and Feng Du and Changming Li and Ruguang Ma and Hongbin Yang and Chunxian Guo}, doi = {10.1002/anie.202415259}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415259}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bimetallic Cu11Ag3 nanotips for ultrahigh yield rate of nitrate-to-ammonium}, volume = {64}, year = {2025}, }
• (2025). In-situ self-respiratory solid-to-hydrogel electrolyte interface evoked well-distributed deposition on zinc anode for highly reversible zinc-ion batteries. ANGEW, 64(3), e202415251. (www)

  @article{ , abstract = {The aqueous zinc-ion batteries (AZIB) have emerged as a promising technology in the realm of electrochemical energy storage. Despite its potential advantages in terms of safety, cost-effectiveness, and inherent safety, AZIB faces significant challenges. Issues attributed to unsupported thermodynamics and non-uniform potential distribution and deposition, present formidable obstacles that necessitate resolution. To tackle these challenges, a novel strategy adapting hybrid organic–inorganic in situ derived solid-to-hydrogel electrolyte interface (StHEI) has been developed from coordination reactions and self-respiratory process, establishing uniform diffusion channels by ion bridges and accelerating ion transport. Self-respiratory pattern of StHEI realized through in situ inorganic component conversion further prolongs the protecting duration, which effectively mitigates corrosion and passivation but enhance the mechanical properties of the StHEI measured through Young's modulus. This novel StHEI promotes well-distributed potential lines within the Helmholtz regions. Zn 2+ are finally induced to deposit and nucleate in a compact, fine, and uniform manner. Asymmetrical batteries assembled with the modified Zn electrode and bare Zn exhibit exceptional stability over 3000 h (1 mA cm −2 –0.5 mAh cm −2 ). The asymmetrical Cu//Zn cell achieved an outstanding average Coulombic efficiency (CE) of 99.6 % over 1200 cycles.}, archive = {J_ANGEW}, author = {Yifan Zhao and Zhiyuan Chen and Xuan Gao and Haobo Dong and Xiaoyu Zhao and Guanjie He and Hui Yang}, doi = {10.1002/anie.202415251}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415251}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In-situ self-respiratory solid-to-hydrogel electrolyte interface evoked well-distributed deposition on zinc anode for highly reversible zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Dynamic organic phosphorescence glass by rigid-soft coupling. ANGEW, 64(3), e202415250. (www)

  @article{ , abstract = {Organic phosphorescence glass has garnered considerable attention owing to the excellent shaping ability and photophysical behavior, but facile construction from single-component phosphors is still challenging. Herein, a rigid-soft coupling design is adopted in organic phosphors of ICO, CCO and PCO, thus preparing phosphorescence glasses through melting-quenching method to give excellent shaping ability and dynamic phosphorescence. RTP performance is significantly enhanced in the dense-structure glass, and intriguing high-temperature phosphorescence (HTP) is still observable even at 400 K. Direct patterning under UV irradiation is also achieved using photolithography technique, allowing for the creation of high-quality afterglow patterns that can be reversibly erased and rewritten. This rigid-soft conformation in organic phosphors elucidates a promising concept for achieving efficient RTP glass with wide application prospects.}, archive = {J_ANGEW}, author = {Meng Zhang and Xiaohui Lan and Meijuan Ding and Chaoyi Han and Xing Wang Liu and Zhengong Meng and Zhen-Qiang Yu and Zhongfu An}, doi = {10.1002/anie.202415250}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415250}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dynamic organic phosphorescence glass by rigid-soft coupling}, volume = {64}, year = {2025}, }
• (2025). Formation of multiple naturally occurring meroterpenoid scaffolds by the norrish-yang reaction of a p-benzoquinone. ANGEW, 64(3), e202415249. (www)

  @article{ , abstract = {The Norrish-Yang reaction, as a typical example, demonstrates the inherent ability of photochemical reaction to facilitate formation of sterically congested C−C bonds, efficiently crafting intricate ring structure in complex organic molecules. Herein we report for the first time a unified synthesis using quinone-based acid-promoted Norrish-Yang photocyclization for the stereoselective construction of multiple avarane-type meroterpenoid natural products.}, archive = {J_ANGEW}, author = {Bing-Yan Liu and Zi-Chun Zhang and Zhi-Lin Song and Hong-Yi Yuan and Yuan-He Li and Zhong-Chao Zhang and Zhen Yang}, doi = {10.1002/anie.202415249}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415249}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Formation of multiple naturally occurring meroterpenoid scaffolds by the norrish-yang reaction of a p-benzoquinone}, volume = {64}, year = {2025}, }
• (2025). A crystalline mesoionic diazasilole featuring low-valent silicon. ANGEW, 64(3), e202415246. (www)

  @article{ , abstract = {A 1,4,2-diazasilole containing a low-valent silicon atom has been synthesized employing a bulky imino N-heterocyclic carbene ligand. This molecular structure is characterized by a mesoionic C 2 N 2 Si five-membered ring, notable for its delocalized π electrons, intrinsic charge-separated zwitterionic properties, and a distinctly nucleophilic silicon center, culminating in 6π aromaticity. This compound manifests either mesoionic silylene or silylone characteristics upon coordination with transition metals. Demonstrating extraordinary versatility, this compound engages in diverse reactions such as coordination with iron or iridium, oxidation by S 8 , intramolecular ring saturation under the coordination influence of iridium, silicon atom transfer facilitated by Ph 2 Se 2 , ring contraction induced by Ph 2 Te 2 , and skeletal rearrangement triggered by Et 3 N•HCl. These reactions culminate in the formation of a variety of unprecedented silicon-based heterocycles, which are typically formidable to achieve using conventional methods. This study unveils previously unexplored facets of low-valent 1,4,2-diazasilole, positioning it as a promising foundational building block for future innovations in unique silicon compounds.}, archive = {J_ANGEW}, author = {Xiaofang Lan and Hongyu Wang and Qiuming Liang and Liu Leo Liu}, doi = {10.1002/anie.202415246}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415246}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A crystalline mesoionic diazasilole featuring low-valent silicon}, volume = {64}, year = {2025}, }
• (2025). Cleavage of carbodicarbenes with N2O for accessing stable diazoalkenes: Two-fold ligand exchange at a c(0)-atom. ANGEW, 64(3), e202415228. (www)

  @article{ , abstract = {The cleavage of carbophosphinocarbenes and carbodicarbenes with nitrous oxide (N 2 O) leads to the formation of room-temperature stable diazoalkenes. The utility of Ph 3 P/N 2 and NHC/N 2 ligand exchange reactions were demonstrated by accessing novel benzimidazole- and benzothiazole derived diazoalkenes, which are not accessible by the current state-of-the-art methods. The stable diazoalkenes subsequently allow further ligand exchange reactions at C(0) with carbon monoxide, isocyanide, or a diamidocarbene (DAC). Overall, the combination of hitherto unknown NHC/N 2 and N 2 /L (L = DAC, CO, R−NC) ligand exchange reactions at a C(0) center allow the selective functionalization of the carbodicarbene ligand structure which represents a new methodology to rapidly assemble novel carbodicarbenes or cumulenic compounds.}, archive = {J_ANGEW}, author = {Yijie He and Yichong Lyu and David Tymann and Patrick W. Antoni and Max M. Hansmann}, doi = {10.1002/anie.202415228}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415228}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cleavage of carbodicarbenes with N2O for accessing stable diazoalkenes: Two-fold ligand exchange at a c(0)-atom}, volume = {64}, year = {2025}, }
• (2025). Fighting mutations with mutations: Evolutionarily adapting a DNA aptamer for high-affinity recognition of mutated spike proteins of SARS-CoV-2. ANGEW, 64(3), e202415226. (www)

  @article{ , abstract = {An on-going challenge with COVID-19, which has huge implications for future pandemics, is the rapid emergence of viral variants that makes diagnostic tools less accurate, calling for rapid identification of recognition elements for detecting new variants caused by mutations. We hypothesize that we can fight mutations of the viruses with mutations of existing recognition elements. We demonstrate this concept via rapidly evolving an existing DNA aptamer originally selected for the spike protein (S-protein) of wildtype SARS-CoV-2 to enhance the interaction with the same protein of the Omicron variants. The new aptamer, MBA5SA1, has acquired 22 mutations within its 40-nucleotide core sequence and improved its binding affinity for the S-proteins of diverse Omicron subvariants by >100-fold compared to its parental aptamer (improved from nanomolar to picomolar affinity). Deep sequencing analysis reveals dynamic competitions among several MBA5SA1 variants in response to increasing selection pressure imposed during in vitro selection, with MBA5SA1 being the final winner of the competition. Additionally, MBA5SA1 was implemented into an enzyme-linked aptamer binding assay (ELABA), which was applied for detecting Omicron variants in the saliva of infected patients. The assay produced a sensitivity of 86.5 % and a specificity of 100 %, which were established with 83 clinical samples.}, archive = {J_ANGEW}, author = {Qing Wang and Jiuxing Li and Zijie Zhang and Ryan Amini and Abigail Derdall and Jimmy Gu and Jianrun Xia and Bruno J. Salena and Deborah Yamamura and Leyla Soleymani and Yingfu Li}, doi = {10.1002/anie.202415226}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415226}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fighting mutations with mutations: Evolutionarily adapting a DNA aptamer for high-affinity recognition of mutated spike proteins of SARS-CoV-2}, volume = {64}, year = {2025}, }
• (2025). Precise synthesis of dual-single-atom electrocatalysts through pre-coordination-directed in situ confinement for CO2 reduction. ANGEW, 64(3), e202415223. (www)

  @article{ , abstract = {Dual-single-atom catalysts (DSACs) are the next paradigm shift in single-atom catalysts because of the enhanced performance brought about by the synergistic effects between adjacent bimetallic pairs. However, there are few methods for synthesizing DSACs with precise bimetallic structures. Herein, a pre-coordination strategy is proposed to precisely synthesize a library of DSACs. This strategy ensures the selective and effective coordination of two metals via phthalocyanines with specific coordination sites, such as −F− and −OH−. Subsequently, in situ confinement inhibits the migration of metal pairs during high-temperature pyrolysis, and obtains the DSACs with precisely constructed metal pairs. Despite changing synthetic parameters, including transition metal centers, metal pairs, and spatial geometry, the products exhibit similar atomic metal pairs dispersion properties, demonstrating the universality of the strategy. The pre-coordination strategy synthesized DSACs shows significant CO 2 reduction reaction performance in both flow-cell and practical rechargeable Zn-CO 2 batteries. This work not only provides new insights into the precise synthesis of DSACs, but also offers guidelines for the accelerated discovery of efficient catalysts.}, archive = {J_ANGEW}, author = {Peng Rao and Xingqi Han and Haochen Sun and Fangyuan Wang and Ying Liang and Jing Li and Daoxiong Wu and Xiaodong Shi and Zhenye Kang and Zhengpei Miao and Peilin Deng and Xinlong Tian}, doi = {10.1002/anie.202415223}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415223}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Precise synthesis of dual-single-atom electrocatalysts through pre-coordination-directed in situ confinement for CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Synergistic regulation of anode and cathode interphases via an alum electrolyte additive for high-performance aqueous zinc-vanadium batteries. ANGEW, 64(3), e202415221. (www)

  @article{ , abstract = {A zinc (Zn) metal anode paired with a vanadium oxide (VO x ) cathode is a promising system for aqueous Zn–ion batteries (AZIBs); however, side reactions proliferating on the Zn anode surface and the infinite dissolution of the VO x cathode destabilise the battery system. Here, we introduce a multi-functional additive into the ZnSO 4 (ZS) electrolyte, KAl(SO 4 ) 2 (KASO), to synchronise the in situ construction of the protective layer on the surface of the Zn anode and the VO x cathode. Theoretical calculations and synchrotron radiation have verified that the high-valence Al 3+ plays dual roles of competing with Zn 2+ for solvation and forming a Zn−Al alloy layer with a homogeneous electric field on the anode surface to mitigate the side reactions and dendrite generation. The Al-containing cathode–electrolyte interface (CEI) considerably alleviates the irreversible dissolution of the VO x cathode and the accumulation of byproducts. Consequently, the Zn||Zn cell with KASO exhibits an ultra-long cycle of 6000 h at 2 mA cm −2 . Importantly, the VO x cathodes (VO 2 , V 2 O 5 and NH 4 V 4 O 10 ) in the ZS−KASO electrolyte showed excellent cycling stability, including Zn powder||VO 2 cells and Zn||VO 2 pouch cells. Even better, the full cell exhibits excellent cycling stability at low negative/positive (N/P) ratio of 2.83 and high mass loading (~16 mg cm −2 ). This study offers a straightforward and practical reference for concurrently addressing challenges at the anode and cathode of AZIBs.}, archive = {J_ANGEW}, author = {Lingjun He and Chuyuan Lin and Lingxing Zeng and Fuyu Xiao and Hui Lin and Peixun Xiong and Qingrong Qian and Qinghua Chen and Zhenhua Yan and Jun Chen}, doi = {10.1002/anie.202415221}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415221}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic regulation of anode and cathode interphases via an alum electrolyte additive for high-performance aqueous zinc-vanadium batteries}, volume = {64}, year = {2025}, }
• (2025). High-entropy Ag−Ru-based electrocatalysts with dual-active-center for highly stable ultra-low-temperature zinc-air batteries. ANGEW, 64(3), e202415216. (www)

  @article{ , abstract = {The development of advanced bifunctional catalysts for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) is significant for rechargeable zinc-air batteries (ZABs). Herein, a unique dual active center alloying strategy is proposed to achieve the efficient bifunctional oxygen catalysis, and the high entropy effect is further exploited to modulate the structure and performance of the catalysts. The MOF-assisted pyrolysis-replacement-alloying method was employed to construct the CoCuFeAgRu high-entropy alloy (HEA), which are uniformly anchored in porous nitrogen-doped carbon nanosheets. Notably, the obtained HEA catalyst exhibits excellent catalytic performance for both ORR and OER, and a peak power density of 136. 53 mW cm −2 and an energy density of 987.9 mAh g Zn −1 , surpassing the most of the previously reported bifunctional oxygen electrocatalysts. Moreover, the assembled flexible rechargeable ZAB enables excellent performance even at the ultralow temperature of −40 °C, with an energy density of 601.6 mAh g Zn −1 and remarkable cycling stability up to 1,650 hours. Combined experimental and theoretical calculation results reveal that the excellent bifunctional catalytic activity of the HEA catalyst originated from the synergistic effect of the Ag and Ru dual active centers, and the optimization of the electronic structure by alloying effect.}, archive = {J_ANGEW}, author = {Ziming Qiu and Xiaotian Guo and Shuai Cao and Meng Du and Qinchao Wang and Yecan Pi and Huan Pang}, doi = {10.1002/anie.202415216}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415216}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-entropy Ag−Ru-based electrocatalysts with dual-active-center for highly stable ultra-low-temperature zinc-air batteries}, volume = {64}, year = {2025}, }
• (2025). Self-polycondensation flux synthesis of ultrastable olefin-linked covalent organic frameworks for electrocatalysis. ANGEW, 64(3), e202415208. (www)

  @article{ , abstract = {Creating new functional materials that efficiently support noble metal catalysts is important and in high demand. Herein, we develop a self-polycondensation flux synthesis strategy that can produce olefin-linked covalent organic framework (COF) platforms with high crystallinity and porosity as the supports of Pd nanoparticles for electrocatalytic nitrogen reduction reaction (ENRR). A series of “two in one” monomers integrating aldehyde and methyl reactive groups are rationally designed to afford COFs with square-shaped pores and ultrahigh chemical stability (e.g., strong acid or alkali environments for >1 month). Functionalizing Fluorine significantly boosts the hydrophobicity of fluoro-functionalized COFs, which can inhibit the competing hydrogen evolution reaction (HER) and enhance ENRR performances. The COFs loading Pd nanoparticles show high NH 3 production yields up to 90.0±2.6 μg ⋅ h −1 ⋅ mg cat. −1 and the faradaic efficiency of 44 % at −0.2 V versus reversible hydrogen electrode, the best comprehensive performance among all reported COFs. Meanwhile, the catalysts are easy to recover and recycle, as demonstrated by their use for 15 cycles and 17 hours, with good performance retention. This work not only provides a new synthesis strategy for olefin-linked COFs, but also paves a new avenue for the design of highly efficient ENRR catalysts.}, archive = {J_ANGEW}, author = {Jiaxi Wang and Qianqian Zhu and Jixian Wang and Ting Wang and Wei Xia and En Lin and Kaiyuan Wang and Heng Hu and Tonghai Wang and Zhifang Wang and Liqin Hao and Yujie Liu and Lifang Jiao and Peng Cheng and Yao Chen and Zhenjie Zhang}, doi = {10.1002/anie.202415208}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415208}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-polycondensation flux synthesis of ultrastable olefin-linked covalent organic frameworks for electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). A tandem catalysis for isoindolinone synthesis over single-atom Pd/TiO2 catalyst. ANGEW, 64(3), e202415203. (www)

  @article{ , abstract = {Developing an efficient strategy to replace the conventional synthesis method for producing isoindolinone (IIO) scaffold, a crucial structural motif for constructing pharmaceutical molecules, remains to be a great challenge. Herein, a single-atom Pd/TiO 2 tandem catalysis has been developed for the IIO scaffold synthesis by using readily available phthalic anhydride (PA), ammonia, and H 2 . The single-atom Pd/TiO 2 catalyst demonstrates superior catalytic performance, achieving a PA conversion of 99 %, an IIO selectivity of 91 %, and a turnover frequency (TOF) up to 4807 h −1 . This exceptional performance can be attributed to the tandem catalysis between TiO 2 support and single-atom Pd. The TiO 2 efficiently catalyzes the conversion of PA with ammonia to form phthalimide (PAM), subsequently transformed into IIO over TiO 2 through the reaction of PAM with NH 3 and the spillover hydrogen species derived from single-atom Pd. Notably, NH 3 functions not only as a reactant but also as a promoter to accelerate the reduction of amides combined with the Pd/TiO 2 catalyst. This tandem catalysis of a single-atom Pd/TiO 2 catalyst provides a promising strategy for the synthesis of the crucial IIO platform molecules.}, archive = {J_ANGEW}, author = {Jin Xie and Jianian Cheng and Junbao Peng and Jieyun Zhang and Xiaojing Wu and Ruihui Zhang and Zelong Li and Can Li}, doi = {10.1002/anie.202415203}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415203}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A tandem catalysis for isoindolinone synthesis over single-atom Pd/TiO2 catalyst}, volume = {64}, year = {2025}, }
• (2025). Covalent organic framework stabilized single CoN4Cl2 site boosts photocatalytic CO2 reduction into tunable syngas. ANGEW, 64(3), e202415202. (www)

  @article{ , abstract = {Solar carbon dioxide (CO 2 ) reduction provides an attractive alternative to producing sustainable chemicals and fuel. However, the construction of a highly active photocatalyst was challenging because of the rapid charge recombination and sluggish surface CO 2 reduction. Herein, a unique Co−N 4 Cl 2 single site was fabricated by loading Co species into the 2,2′-bipyridine and triazine-containing covalent organic framework (COF) for CO 2 conversion into syngas under visible light irradiation. The resulting champion catalyst TPy-COF-Co enabled a record-high CO production rate of 426 mmol g −1 h −1 , associated with the unprecedented turnover number (TON) and turnover frequency (TOF) of 2095 and 1607 h −1 , respectively. The catalyst also exhibited favorable recycling performance and widely adjustable syngas production (CO/H 2 ratio: 1.8 : 1–1 : 16). A systematical investigation including operando synchrotron X-ray absorption fine structure (XAFS) spectroscopy, in situ attenuated total reflection surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS), and theoretical calculation indicated that the triazine-based COF framework promoted the charge transfer towards the single Co−N 4 Cl 2 sites that greatly promoted the CO 2 activation by lowering the energy barrier of *COOH generation, facilitating the CO 2 transformation. This work highlights the great potential of the molecular regulation of COF-derived single-atom catalysts to boost CO 2 photoreduction efficiency.}, archive = {J_ANGEW}, author = {Ping Fu and Cailing Chen and Chao Wu and Biao Meng and Qihong Yue and Tao Chen and Wen Yin and Xiao Chi and Xiaojiang Yu and Ruiting Li and Yao Wang and Yifan Zhang and Wen Luo and Xiaoling Liu and Yu Han and Jun Wang and Shibo Xi and Yu Zhou}, doi = {10.1002/anie.202415202}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415202}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Covalent organic framework stabilized single CoN4Cl2 site boosts photocatalytic CO2 reduction into tunable syngas}, volume = {64}, year = {2025}, }
• (2025). Catalytic enantioselective synthesis of planar chiral pillar[5]arenes via asymmetric sonogashira coupling. ANGEW, 64(3), e202415190. (www)

  @article{ , abstract = {As a novel type of macrocycles with attractive planar chirality, pillar[5]arenes have gained increasing research interest over the past decades, enabling their widespread applications in diverse fields such as porous materials, molecular machines, and chiral luminescence materials. However, the catalytic methodology towards the enantioselective synthesis of planar chiral pillar[5]arenes remains elusive. Here we report a novel method for the enantioselective synthesis of planar chiral pillar[5]arenes via asymmetric Sonogashira coupling, giving access to a wide range of highly functionalized planar chiral pillar[5]arenes, including both homo- and hetero-rimmed ones, with excellent enantioselectivities. Attractively, the resultant planar chiral pillar[5]arenes show great potential for widespread use in many areas such as chiral luminescent materials. This work not only enables the successful synthesis of planar chiral pillar[5]arenes with abundant structural and functional diversity as key building blocks for practical applications but also enriches the asymmetric cross-coupling methodologies in organic synthetic chemistry.}, archive = {J_ANGEW}, author = {Xiao-Hua Zhou and Xin Zhang and Yi-Ru Song and Xue Li and Lin-Tao Bao and Wei-Tao Xu and Xu-Qing Wang and Hai-Bo Yang and Wei Wang}, doi = {10.1002/anie.202415190}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415190}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic enantioselective synthesis of planar chiral pillar[5]arenes via asymmetric sonogashira coupling}, volume = {64}, year = {2025}, }
• (2025). Stereocontrolled hydrogenation of conjugated enones to alcohols via dual iridium-catalysis. ANGEW, 64(3), e202415171. (www)

  @article{ , abstract = {The concept of dual catalysis is an emerging area holding high potential in terms of preparative efficiency, yet faces severe challenges in compatibility of reaction conditions and interference of catalysts. The transition-metal catalyzed stereoselective hydrogenation of olefins and ketones typically proceeds under different reaction conditions and/or uses a different reductant. As a result, these two types of hydrogenations can normally not be performed in the same pot. Herein, the stereocontrolled hydrogenation of enones to saturated alcohols is described, enabled by orthogonal dual iridium catalysis, using molecular hydrogen for both reductions. In this one-pot procedure, N,P-iridium catalysts (hydrogenation active towards olefins) and NHC,P-iridium catalysts (hydrogenation active towards ketones) operated independently of one another allowing the construction of two contiguous stereogenic centers up to 99 % ee , 99/1 d.r. Ultimately, by simple selection of the chirality of either ligands, the enone could be efficiently reduced to all four stereoisomers of the saturated alcohol in equally high stereopurity. This degree of stereocontrol for the synthesis of different stereoisomers by dual transition-metal catalyzed hydrogenation was previously not attained. The generality in substituted enones (alkyl, aryl, heteroaryl) demonstrate the wide applicability of this concept.}, archive = {J_ANGEW}, author = {Jia Zheng and Bram B. C. Peters and Rajendra K. Mallick and Pher G. Andersson}, doi = {10.1002/anie.202415171}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415171}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereocontrolled hydrogenation of conjugated enones to alcohols via dual iridium-catalysis}, volume = {64}, year = {2025}, }
• (2025). The first-in-class deubiquitinase-targeting chimera stabilizes and activates cGAS. ANGEW, 64(3), e202415168. (www)

  @article{ , abstract = {Deubiquitinase-targeting chimera (DUBTAC) is a promising technology for inducing targeted protein stabilization (TPS). Despite its therapeutic potential, very few proteins have been stabilized by DUBTACs to date. The limited applicability of this technology is likely due to the modest DUBTAC-induced protein stabilization effect, and the scarcity of effective deubiquitinase ligands that can be harnessed for DUBTAC development. Here, we report the discovery of MS7829 and MS8588, the first-in-class DUBTACs of cGAS, a key component of the cGAS-STING pathway. While these DUBTACs are based on a cGAS inhibitor, they effectively stabilized cGAS and activated the cGAS/STING/IRF3 signaling. To develop these cGAS DUBTACs, we optimized EN523, an OTUB1 covalent ligand, into an improved ligand, MS5105. We validated MS5105 by generating a MS5105-based CFTR DUBTAC, which was approximately 10-fold more effective in stabilizing the ΔF508-CFTR mutant protein than the previously reported EN523-based CFTR DUBTAC. Overall, this work advances the DUBTAC technology for TPS.}, archive = {J_ANGEW}, author = {Zhijie Deng and Li Chen and Chao Qian and Jing Liu and Qiong Wu and Xiangyang Song and Yan Xiong and Zhen Wang and Xiaoping Hu and Hiroyuki Inuzuka and Yue Zhong and Yufei Xiang and Yindan Lin and Ngoc Dung Pham and Yi Shi and Wenyi Wei and Jian Jin}, doi = {10.1002/anie.202415168}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415168}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The first-in-class deubiquitinase-targeting chimera stabilizes and activates cGAS}, volume = {64}, year = {2025}, }
• (2025). Access to alkenyl cyclobutanols by ni-catalyzed regio- and enantio-selective syn-hydrometalative 4-exo-trig cyclization of alkynones. ANGEW, 64(3), e202415164. (www)

  @article{ , abstract = {Enantioselective synthesis of (spiro)cyclobutane derivatives poses significant challenges yet holds promising applications for both synthetic and medicinal chemistry. We report here a nickel-catalyzed asymmetric syn -hydrometalative 4- exo - trig cyclization of 1,4-alkynones to synthesize alkenyl cyclobutanols with a tetrasubstituted stereocenter. This strategy features a broad substrate scope, delivering a variety of trifluoromethyl-containing rigid (spiro)carbocycle skeletons in good yields with high enantioselectivities (up to 84 % yield and 98.5 : 1.5 er). The synthetic utility is demonstrated through stereospecific transformations into fused spiro molecules. Experimental and computational mechanistic studies indicate that the reaction is initiated by an active Ni−H species, with carbonyl-directed hydrometalation as the key for regioselective control. This catalytic method provides a general solution for regioselective hydrofunctionalization of alkynes and represents an efficient reaction pattern for assembling highly strained enantioenriched bioisosteres.}, archive = {J_ANGEW}, author = {Xiao-Lin Li and Jiang-Lian Deng and Jian Long and Yi-Fan Fu and Yu-Qing Zheng and Wen-Bo Liu}, doi = {10.1002/anie.202415164}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415164}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Access to alkenyl cyclobutanols by ni-catalyzed regio- and enantio-selective syn-hydrometalative 4-exo-trig cyclization of alkynones}, volume = {64}, year = {2025}, }
• (2025). Location-specific microenvironment modulation around single-atom metal sites in Metal–Organic frameworks for boosting catalysis. ANGEW, 64(3), e202415155. (www)

  @article{ , abstract = {Despite coordination environment of catalytic metal sites has been recognized to be of great importance in single-atom catalysts (SACs), a significant challenge remains in the understanding how the location-specific microenvironment in the higher coordination sphere influences their catalysis. Herein, a series of Cu-based SACs, namely Cu 1 /UiO-66-X (X=-NO 2 , -H, and -NH 2 ), are successfully constructed by anchoring single Cu atoms onto the Zr-oxo clusters of metal–organic frameworks (MOFs), i.e., UiO-66-X. The -X functional groups dangling on the MOF linkers could be regarded as location-specific remote microenvironment to regulate electronic properties of the single Cu atoms. Remarkably, they exhibit significant differences in the catalysis toward the hydroboration of alkynes. The activity follows the order of Cu 1 /UiO-66-NO 2 > Cu 1 /UiO-66 > Cu 1 /UiO-66-NH 2 under identical reaction conditions, where Cu 1 /UiO-66-NO 2 showcases the phenylacetylene conversion of 92 %, ~3.5 times higher efficiency than that of Cu 1 /UiO-66-NH 2 . Experimental and calculation results jointly support that the Cu electronic structure is modulated by the location-specific microenvironment, thereby regulating the product desorption and promoting the catalysis.}, archive = {J_ANGEW}, author = {Shuaishuai Hu and Jiajia Huang and Ming-Liang Gao and Zhongyuan Lin and Yunyang Qian and Weijie Yang and Long Jiao and Hai-Long Jiang}, doi = {10.1002/anie.202415155}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415155}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Location-specific microenvironment modulation around single-atom metal sites in Metal–Organic frameworks for boosting catalysis}, volume = {64}, year = {2025}, }
• (2025). Non-fused star-shape giant trimer electron acceptors for organic solar cells with efficiency over 19 %. ANGEW, 64(3), e202415141. (www)

  @article{ , abstract = {Organic solar cells (OSCs) based on giant molecular acceptors (GMAs) have attracted extensive attention due to their excellent power conversion efficiency (PCE) and operation stability. However, the large conjugated plane of GMAs poses great challenges in regulating the solubility, over-size aggregation and yield, which in turn further constrains their development in commercial products. Herein, we employ a non-fused skeleton strategy to develop novel non-fused star-shape trimers (3BTT6F and 3BTT6Cl) for improving device performance. Single-bond linkage can break the rigid planarity to form a 3D architecture, generating multidimensional charge transfer pathways. Importantly, the non-fused skeleton strategy can not only significantly improve solubility and synthesis yield, but also effectively suppress molecular excessive aggregation. Consequently, due to the optimized film-forming process and charge dynamics, 3BTT6F-based binary device obtains a high PCE of 17.52 %, which is significantly higher than the reported fully fused trimers. Excitingly, 3BTT6F-based ternary device even obtains a top-level PCE of 19.26 %. Furthermore, the non-fused star-shape configuration also endows these acceptors with enhanced intermolecular interaction in the active layer, demonstrating excellent operational stability. Our work emphasizes the potential of non-fused star-shape trimers, providing a new pathway for achieving highly efficient and stable OSCs.}, archive = {J_ANGEW}, author = {Wen Zhou and Jiabin Liu and Jiaping Xie and Shiyong You and Jiawei Deng and Fan Yu and Sang Young Jeong and Han Young Woo and Feiyan Wu and Lie Chen}, doi = {10.1002/anie.202415141}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415141}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-fused star-shape giant trimer electron acceptors for organic solar cells with efficiency over 19 %}, volume = {64}, year = {2025}, }
• (2025). Ion-pairing chromonic liquid crystals via alternately stacked assembly of amphiphilic charged π-electronic systems. ANGEW, 64(3), e202415135. (www)

  @article{ , abstract = {In this study, a new assembly strategy for lyotropic chromonic liquid crystals (LCLCs) is proposed using i π– i π interactions, mainly comprising electrostatic and dispersion forces, between charged π-electronic systems to form stacking structures supported by the hydration of triethylene glycol (TEG) units. The meso -TEG-aryl-substituted porphyrin Au III complex, an amphiphilic π-electronic cation, showed diverse states and assembly modes in ion pairs depending on the coexisting counteranions. The PCCp − ion pair formed a hexagonal columnar (Col h ) LC phase based on a charge-by-charge assembly, suggesting the formation of an ordered arrangement of charged π-electronic systems through i π– i π interactions, with reduced interactions between the TEG chains. Furthermore, in the presence of water, LCLC behavior in the Col h and nematic columnar phases according to the amount of water were observed for the PCCp − ion pair as a result of i π– i π interactions. Magnetic-field-induced orientation of the charge-by-charge columnar structures upon dehydration was observed. Furthermore, single-stranded charge-by-charge columnar structures, as components of the LCLCs, were observed using transmission electron microscopy (TEM).}, archive = {J_ANGEW}, author = {Yuto Maruyama and Koji Harano and Hayato Kanai and Yasuhiro Ishida and Hiroki Tanaka and Shinya Sugiura and Hiromitsu Maeda}, doi = {10.1002/anie.202415135}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415135}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ion-pairing chromonic liquid crystals via alternately stacked assembly of amphiphilic charged π-electronic systems}, volume = {64}, year = {2025}, }
• (2025). Oxyanions enhancing crystallinity of reconstructed phase for oxygen evolution reaction. ANGEW, 64(3), e202415132. (www)

  @article{ , abstract = {The catalysts were always undergoing continuous amorphization and dissolution of active structure in operating condition, hindering the compatibility between stability and activity for oxygen evolution reaction (OER). Herein, we propose the selective adsorption of leached NO 3 − to strengthen the crystallinity and activity of surface reconstructed layer with amorphous and crystalline (a-c) heterojunction. Taking a-c Ni doped Fe 2 O(OH) 3 NO 3 ⋅ H 2 O (Ni−FeNH) as a model precatalyst, we uncover that the leached NO 3 − are readily adsorbs on the crystalline phase in the formed a-c Fe(Ni)OOHduring OER, lowering the disorder degree and further activating Ni and Fe ion of the crystalline Fe(Ni)OOH on a-c heterojunctions. Accordingly, Ni−FeNH deliver a low overpotential of 303 mV and high durability of 500 hours at 500 mA cm −2 for OER. Particularly, constructing industrial water electrolysis equipment exhibits high stability of 100 hours under a high operating current of 8000 mA.}, archive = {J_ANGEW}, author = {Wenbin Wang and Qunlei Wen and Danji Huang and Yu Lin and Niandan Zhao and Lan Tang and Ming Li and Youwen Liu and Rongxing He}, doi = {10.1002/anie.202415132}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415132}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxyanions enhancing crystallinity of reconstructed phase for oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). NADH analogues enable metal- and light-free decarboxylative functionalization. ANGEW, 64(3), e202415131. (www)

  @article{ , abstract = {Here we report a metal- and light-free decarboxylative functionalization approach enabled by reduced nicotinamide adenine dinucleotide (NADH) analogues. The efficient and operationally simple approach, conducted in 5 minutes from in situ preparation of aryliodine (III) dicarboxylates under open-air and ambient conditions, enables diverse bond formation and exhibits a broad substrate scope of over 70 examples. Late-stage functionalization of drug molecules and natural products further demonstrates the synthetic utility of this method. Combined experimental and computational studies elucidate the mechanistic pathway. These transformations streamline the synthesis of sp 3 carbon-enriched compounds, adding a new dimension to classical decarboxylative reactions.}, archive = {J_ANGEW}, author = {Lei Liang and Yue-Hui Wang and Cheng-Xing Cui and Xiao-Shan Deng and Song-Lin Wang and Hai-Ming Guo and Yingzi Li and Hong-Ying Niu and Runze Mao}, doi = {10.1002/anie.202415131}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415131}, shortjournal = {Angew. Chem. Int. Edit.}, title = {NADH analogues enable metal- and light-free decarboxylative functionalization}, volume = {64}, year = {2025}, }
• (2025). Shotgun sequencing of 512-mer copolyester allows random access to stored information. ANGEW, 64(3), e202415124. (www)

  @article{ , abstract = {Digital information encoded in polymers has been exclusively decoded by mass spectrometry. However, the size limit of analytes in mass spectrometry restricts the storage capacity per chain. In addition, sequential decoding hinders random access to the bits of interest without full-chain sequencing. Here we report the shotgun sequencing of a 512-mer sequence-defined polymer whose molecular weight (57.3 kDa) far exceeds the analytical limit of mass spectrometry. A 4-bit fragmentation code was implemented at aperiodic positions during the synthetic encoding of 512-bit information without affecting storage capacity per chain. Upon activating the fragmentation code, the polymer chain splits into 18 oligomers, which could be individually decoded by tandem-mass sequencing. These sequences were computationally reconstructed into a full sequence using an error-detection method. The proposed sequencing method eliminates the storage limit of a single polymer chain and allows random access to the bits of interest without full-chain sequencing.}, archive = {J_ANGEW}, author = {Heejeong Jang and Hyunseon Chu and Hyojoo Noh and Kyoung Taek Kim}, doi = {10.1002/anie.202415124}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415124}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Shotgun sequencing of 512-mer copolyester allows random access to stored information}, volume = {64}, year = {2025}, }
• (2025). Multiple resonance quasi-fluorescence from BN-doped aromatic compounds modified with “Naphthalene” units approaches the BT.2020 green light standard. ANGEW, 64(3), e202415113. (www)

  @article{ , abstract = {Developing fluorophores that conform to the Broadcast Service Television 2020 (BT.2020) standard presents a formidable challenge. Here, we propose an innovative approach that integrates two and three-boron/nitrogen (BN2)-embedded [4]helicene subunits with naphthalene, resulting in the synthesis of two novel narrowband bright green quasi-fluorescent emitters, NT-2B and NT-3B for ultra-high-definition displays. These emitters exhibit minimal reorganization energy and Huang–Rhys factor, emitting at 510 and 511 nm in dilute toluene solution with exceptionally narrow full width at half maximum values of 15 and 14 nm, respectively. Notably, NT-2B demonstrates an impressive photoluminescence quantum yield of 92.5 %, rapid radiative decay rate, and slow non-radiative decay rate. Owing to their narrowband emission characteristics and outstanding optoelectronic properties, corresponding OLEDs based on NT-2B demonstrate a high external quantum efficiency of 30.6 %, with an FWHM value of 21.5 nm and a CIE y of 0.74, positioning it as one of the leading narrow-band green emitters.}, archive = {J_ANGEW}, author = {Tingting Feng and Xuewei Nie and Denghui Liu and Lin Wu and C. Y. Liu and Xilin Mu and Ziru Xin and Bohong Liu and Hengxuan Qi and Jiasen Zhang and Wei Li and Shi-Jian Su and Ziyi Ge}, doi = {10.1002/anie.202415113}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415113}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multiple resonance quasi-fluorescence from BN-doped aromatic compounds modified with “Naphthalene” units approaches the BT.2020 green light standard}, volume = {64}, year = {2025}, }
• (2025). Achieving sub-ppm sensitivity in SO2 detection with a chemically stable covalent organic framework. ANGEW, 64(3), e202415088. (www)

  @article{ , abstract = {We report the inaugural experimental investigation of covalent organic frameworks (COFs) to address the formidable challenge of SO 2 detection. Specifically, an imine-functionalized COF (SonoCOF-9) demonstrated a modest and reversible SO 2 sorption of 3.5 mmol g −1 at 1 bar and 298 K. At 0.1 bar (and 298 K), the total SO 2 uptake reached 0.91 mmol g −1 with excellent reversibility for at least 50 adsorption-desorption cycles. An isosteric enthalpy of adsorption (Δ H ads ) for SO 2 equaled −42.3 kJ mol −1 , indicating a relatively strong interaction of SO 2 molecules with the COF material. Also, molecular dynamics simulations and Møller–Plesset perturbation theory calculations showed the interaction of SO 2 with π density of the rings and lone pairs of the N atoms of SonoCOF-9. The combination of experimental data and theoretical calculations corroborated the potential use of this COF for the selective detection and sensing of SO 2 at the sub-ppm level (0.0064 ppm of SO 2 ).}, archive = {J_ANGEW}, author = {Wei Zhao and Juan L. Obeso and Valeria B. López-Cervantes and Mounib Bahri and Elí Sánchez-González and Yoarhy A. Amador-Sánchez and Junyu Ren and Nigel D. Browning and Ricardo A. Peralta and Giovanni Barcaro and Susanna Monti and Diego Solis-Ibarra and Ilich A. Ibarra and Dan Zhao}, doi = {10.1002/anie.202415088}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415088}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Achieving sub-ppm sensitivity in SO2 detection with a chemically stable covalent organic framework}, volume = {64}, year = {2025}, }
• (2025). Integrated design of Homogeneous/Heterogeneous copper complex catalysts to enable synergistic effects on sulfur and lithium evolution reactions. ANGEW, 64(3), e202415078. (www)

  @article{ , abstract = {Fatal polysulfide shuttling, sluggish sulfur redox kinetics and detrimental lithium dendrites have curtailed the real discharge capacity, working lifespan and safety of lithium−sulfur (Li−S) batteries. Organic small molecule promotors as one type of emerging active catalysts can fulfil the management of the electrochemical species evolution behaviors. Herein, an integrated engineering is organized by synthesizing dual chlorine-bridge enabled binuclear copper complex (Cu 2 (phen) 2 Cl 2 ) and its derivative generated in electrolyte (Cu-ETL) as the heterogeneous and homogeneous catalyst, respectively. The well-designed Cu-ETL with a optimized concentration of 0.25 wt% as a homogeneous enabler offers highly utilized Cu centers and the sufficient interface contact for guiding the Li 2 S nucleation/decomposition reactions. The Cu 2 (phen) 2 Cl 2 loaded on carbon spheres as an interlayer (Cu-INT) can break through the catalytic limitation resulting from the saturated concentration of Cu-ETL and thus offers an extended manipulation effect. Benefiting from the synergistic effect, the Li−S battery shows stable cycling at 3 C upon 500 cycles with a capacity degradation rate as low as 0.029 % per cycle. Of specific note, an actual cell energy density of 372.1 Wh kg −1 is harvested by a 1.2 Ah-level soft-packaged pouch cell, implying a chance for requiring the demand of high-energy batteries.}, archive = {J_ANGEW}, author = {Qin Yang and Chensheng Wang and Lixian Song and Yunfeng Zhang and Zhaoyang Shen and Wenlong Cai and Yingze Song}, doi = {10.1002/anie.202415078}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415078}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrated design of Homogeneous/Heterogeneous copper complex catalysts to enable synergistic effects on sulfur and lithium evolution reactions}, volume = {64}, year = {2025}, }
• (2025). Carbodicarbene-stibenium ion-mediated functionalization of C(sp3)−H and C(sp)−H bonds. ANGEW, 64(3), e202415070. (www)

  @article{ , abstract = {Main-group element-mediated C−H activation remains experimentally challenging and the development of clear concepts and design principles has been limited by the increased reactivity of relevant complexes, especially for the heavier elements. Herein, we report that the stibenium ion [( py CDC)Sb][NTf 2 ] 3 ( 1 ) ( py CDC=bis-pyridyl carbodicarbene; NTf 2 =bis(trifluoromethanesulfonyl)imide) reacts with acetonitrile in the presence of the base 2,6-di- tert -butylpyridine to enable C(sp 3 )−H bond breaking to generate the stiba-methylene nitrile complex [( py CDC)Sb(CH 2 CN)][NTf 2 ] 2 ( 2 ). Kinetic analyses were performed to elucidate the rate dependence for all the substrates involved in the reaction. Computational studies suggest that C−H activation proceeds via a mechanism in which acetonitrile first coordinates to the Sb center through the nitrogen atom in a κ 1 fashion, thereby weakening the C−H bond which can then be deprotonated by base in solution. Further, we show that 1 reacts with terminal alkynes in the presence of 2,6-di- tert -butylpyridine to enable C(sp)−H bond breaking to form stiba-alkynyl adducts of the type [( py CDC)Sb(CCR)][NTf 2 ] 2 ( 3 a – f ). Compound 1 shows excellent specificity for the activation of the terminal C(sp)−H bond even across alkynes with diverse functionality. The resulting stiba-methylene nitrile and stiba-alkynyl adducts react with elemental iodine (I 2 ) to produce iodoacetonitrile and iodoalkynes, while regenerating an Sb trication.}, archive = {J_ANGEW}, author = {Levi Warring and Karl S. Westendorff and Marc T. Bennett and Kijeong Nam and Brennan M. Stewart and Diane A. Dickie and Christopher Paolucci and T. Brent Gunnoe and Robert J. Gilliard}, doi = {10.1002/anie.202415070}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415070}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbodicarbene-stibenium ion-mediated functionalization of C(sp3)−H and C(sp)−H bonds}, volume = {64}, year = {2025}, }
• (2025). Inverse design of singlet-fission materials with uncertainty-controlled genetic optimization. ANGEW, 64(3), e202415056. (www)

  @article{ , abstract = {Singlet fission has shown potential for boosting the efficiency of solar cells, but the scarcity of suitable molecular materials hinders its implementation. We introduce an uncertainty-controlled genetic algorithm (ucGA) based on ensemble machine learning predictions from different molecular representations that concurrently optimizes excited state energies, synthesizability, and exciton size for the discovery of singlet fission materials. The ucGA allows us to efficiently explore the chemical space spanned by the reFORMED fragment database, which consists of 45,000 cores and 5,000 substituents derived from crystallographic structures assembled in the FORMED repository. Running the ucGA in an exploitative setup performs local optimization on variations of known singlet fission scaffolds, such as acenes. In an explorative mode, hitherto unknown candidates displaying excellent excited state properties for singlet fission are generated. We suggest a class of heteroatom-rich mesoionic compounds as acceptors for charge-transfer mediated singlet fission. When included in larger donor-acceptor systems, these units exhibit localization of the triplet state, favorable diradicaloid character and suitable triplet energies for exciton injection into semiconductor solar cells.}, archive = {J_ANGEW}, author = {Luca Schaufelberger and J. Terence Blaskovits and Ruben Laplaza and Kjell Jorner and Clemence Corminboeuf}, doi = {10.1002/anie.202415056}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415056}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inverse design of singlet-fission materials with uncertainty-controlled genetic optimization}, volume = {64}, year = {2025}, }
• (2025). Highly solvating electrolytes with core-shell solvation structure for lean-electrolyte lithium-sulfur batteries. ANGEW, 64(3), e202415053. (www)

  @article{ , abstract = {The practical energy density of lithium-sulfur batteries is limited by the low sulfur utilization at lean electrolyte conditions. The highly solvating electrolytes (HSEs) promise to address the issue at harsh conditions, but the conflicting challenges of long-term stability of radical-mediated sulfur redox reactions (SRR) and the poor stability with lithium metal anode (LMA) have dimmed the efforts. We now present a unique core–shell solvation structured HSE formulated with classical ether-based solvents and phosphoramide co-solvent. The unique core–shell solvation structure features confinement of the phosphoramide in the first solvation shell, which prohibits severe contact reactions with LMA and endows prolonged stability for [S 3 ]⋅ − radical, favoring a rapid radical-mediated solution-based SRR. The cell with the proposed electrolyte showing a high capacity of 864 mAh g sulfur −1 under high sulfur loading of 5.5 mg sulfur cm −2 and low E/S ratio of 4 μL mg sulfur −1 . The strategy further enables steady cycling of a 2.71-A h pouch cell with a high specific energy of 307 W h kg −1 . Our work highlights the fundamental chemical concept of tuning the solvation structure to simultaneously tame the SRR and LMA stability for metal-sulfur batteries wherein the electrode reactions are heavily coupled with electrolyte chemistry.}, archive = {J_ANGEW}, author = {Mengxue He and Lujun Zhu and Yatao Liu and Yongfeng Jia and Yizhou Hao and Guo Ye and Xufeng Hong and Zhitong Xiao and Yue Ma and Jianhao Chen and Muhammad Burhan Shafqat and Quanquan Pang}, doi = {10.1002/anie.202415053}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415053}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly solvating electrolytes with core-shell solvation structure for lean-electrolyte lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Mechanochemical thioglycolate modification of microscale zero-valent iron for superior heavy metal removal. ANGEW, 64(3), e202415051. (www)

  @article{ , abstract = {Microscale zero-valent iron (mZVI) is widely used for water pollutant control and environmental remediation, yet its reactivity is still constrained by the inert oxide shell. Herein, we demonstrate that mechanochemical thioglycolate (TG) modification can dramatically enhance heavy metal (Ni II , Cr VI , Cd II , Pb II , Hg II , and Sb III ) removal rates of mZVI by times of 16.7 to 88.0. Compared with conventional impregnation (wet chemical process), this dry mechanochemical process could construct more robust covalent bonding between TG and the inert oxide shell of mZVI through its electron-withdrawing carboxylate group to accelerate the electron release from the iron core, and more effectively strengthen the surface heavy metal adsorption through metal(d)-sulfur(p) orbital hybridization between its thiol group and heavy metal ions. Impressively, this mechanochemically TG-modified mZVI exhibited an unprecedented Ni II removal capacity of 580.4 mg Ni g −1 Fe, 17.1 and 9.5 times those of mZVI and wet chemically TG-modified mZVI, respectively. Its application potential was further validated by more than 10 days of stable groundwater Ni II removal in a column flow reactor. This study offers a promising strategy to enhance the reactivity of mZVI, and also emphasizes the importance of the modification strategy in optimizing its performance for environmental applications.}, archive = {J_ANGEW}, author = {Junning Zu and Nuanqin Zhang and Xupeng Liu and Yuqing Hu and Linghao Yu and Ziyue Chen and Hao Zhang and Hao Li and Lizhi Zhang}, doi = {10.1002/anie.202415051}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415051}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanochemical thioglycolate modification of microscale zero-valent iron for superior heavy metal removal}, volume = {64}, year = {2025}, }
• (2025). High-performance complementary electrochromic batteries using Nb18W16O93 by the synergistic effects of aqueous Al3+/K+ dual-ion. ANGEW, 64(3), e202415050. (www)

  @article{ , abstract = {Multivalent ions, especially Al 3+ in aqueous electrolyte contributes to higher capacity and color contrast for more sustainable post-lithium electrochromism and energy storages. However, the lack of suitable cathodic and anodic electrochromic materials is a major challenge for Al-ion electrochromic batteries, which limits their optical contrast and lifespan. Herein, we report that Wadsley-Roth phase Nb 18 W 16 O 93 with open structure achieves Al 3+ intercalation/extraction reversibly. The complementary electrochromic energy storage devices based on Nb 18 W 16 O 93 coupled with Prussian blue using hybrid Al 3+ /K + aqueous electrolytes show a fast response, a high capacity and a large coloring efficiency. The superior performances are due to the cations of Al 3+ and K + selectively insert/extract in the electrode of Nb 18 W 16 O 93 and Prussian blue, respectively. This work provides an effective strategy for high-performance and low-cost electrochromic batteries with higher sustainability.}, archive = {J_ANGEW}, author = {Cong Wu and Yining Zhang and Hongsheng Shi and Jiameng Yu and Yihang Yang and Chang Zhang and Yi Yu and Wei Liu}, doi = {10.1002/anie.202415050}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415050}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-performance complementary electrochromic batteries using Nb18W16O93 by the synergistic effects of aqueous Al3+/K+ dual-ion}, volume = {64}, year = {2025}, }
• (2025). A green and efficient electrocatalytic route for the highly-selective oxidation of C−H bonds in aromatics over 1D Co3O4-based nanoarrays. ANGEW, 64(3), e202415044. (www)

  @article{ , abstract = {Electrocatalytic oxidation of C−H bonds in hydrocarbons represents an efficient and sustainable strategy for the synthesis of value-added chemicals. Herein, a highly selective and continuous-flow electrochemical oxidation process of toluene to various oxygenated products (benzyl alcohol, benzaldehyde, and benzyl acetate) is developed with the electrocatalytic membrane electrodes (ECMEs). The selectivity of target products can be manipulated via surface and interface engineering of Co 3 O 4 -based electrocatalysts. We achieved a high benzaldehyde selectivity of 90 % at a toluene conversion of 47.6 % using 1D Co 3 O 4 nanoneedles (NNs) loaded on a microfiltration (MF) titanium (Ti) membrane, i.e, Co 3 O 4 NNs/Ti. In contrast, the main product shifted to benzyl alcohol with a selectivity of 90.1 % at a conversion of 32.1 % after modifying MnO 2 nanosheets (NSs) on Co 3 O 4 NNs/Ti (Co 3 O 4 @MnO 2 /Ti) catalyst. Moreover, benzyl acetate product can be obtained with a selectivity of 92 % at a conversion of 58.5 % at high current density (>1.5 mA cm −2 ), demonstrating that the pathway of toluene oxidation is readily maneuvered. DFT results reveal that modifying MnO 2 on Co 3 O 4 optimizes the electron structure of Co 3 O 4 @MnO 2 /Ti and modulates the adsorption behavior of intermediate species. This work demonstrates a sustainable, efficient, and continuous-flow process for precise control over the production selectivity of value-added oxygenated derivatives in the electrochemical oxidation of aromatic hydrocarbons.}, archive = {J_ANGEW}, author = {Zhaohui Yin and Zirui Gao and Lan Luo and Xiaohui Zhang and Wenxiang Hou and Wenjing Dai and Shuheng Tian and Xuetao Qin and Maolin Wang and Mi Peng and Kaihua Li and Songbo Wang and Lei Zhang and Hong Wang and Jianxin Li and Qingjun Zhu and Bowen Cheng and Zhen Yin and Ding Ma}, doi = {10.1002/anie.202415044}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415044}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A green and efficient electrocatalytic route for the highly-selective oxidation of C−H bonds in aromatics over 1D Co3O4-based nanoarrays}, volume = {64}, year = {2025}, }
• (2025). Metal-N coordination in lithium-sulfur batteries: Inhibiting catalyst passivation. ANGEW, 64(3), e202415036. (www)

  @article{ , abstract = {Lithium-sulfur (Li−S) batteries exhibit great potential as the next-generation energy storage techniques. Application of catalyst is widely adopted to accelerate the redox kinetics of polysulfide conversion reactions and improve battery performance. Although significant attention has been devoted to seeking new catalysts, the problem of catalyst passivation remains underexplored. Herein, we find that metal-N coordination has a previously overlooked role in preventing the catalyst passivation. In the case of nickel, the Ni catalyst reacts with S 8 to produce NiS x compounds on the surface, leading to catalyst passivation and slow the kinetics of LiPSs conversion. In contrast, when Ni is coordinated with N (typically Ni−N 4 ), S 8 remains stable on the surface. The Ni−N 4 exhibits excellent resistance to passivation and rapid kinetics of LiPSs conversion. Consequently, the sulfur cathode with Ni−N 4 exhibits a high rate capability of 604.11 mAh g −1 at 3 C and maintains a low capacity decay rate of 0.046 % per cycle over 1000 cycles at 2 C. Furthermore, preventing S passivation in M−N coordination applies not only to Ni−N 4 but also to various coordination numbers and transition metals. This study reveals a new aspect of metal-N coordination in inhibiting catalyst passivation, improving our understanding of catalysts in Li−S batteries.}, archive = {J_ANGEW}, author = {Xin Ao and Yang Kong and Shangquan Zhao and Zhongxin Chen and Yong Li and Xingyu Liao and Bingbing Tian}, doi = {10.1002/anie.202415036}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415036}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metal-N coordination in lithium-sulfur batteries: Inhibiting catalyst passivation}, volume = {64}, year = {2025}, }
• (2025). Honeycomb-structured IrOx foam platelets as the building block of anode catalyst layer in PEM water electrolyzer. ANGEW, 64(3), e202415032. (www)

  @article{ , abstract = {Achieving robust long-term durability with high catalytic activity at low iridium loading remains one of great challenges for proton exchange membrane water electrolyzer (PEMWE). Herein, we report the low-temperature synthesis of iridium oxide foam platelets comprising edge-sharing IrO 6 octahedral honeycomb framework, and demonstrate the structural advantages of this material for multilevel tuning of anodic catalyst layer across atomic-to-microscopic scales for PEMWE. The integration of IrO 6 octahedral honeycomb framework, foam-like texture and platelet morphology into a single material system assures the generation and exposure of highly active and stable iridium catalytic sites for the oxygen evolution reaction (OER), while facilitating the reduction of both mass transport loss and electronic resistance of catalyst layer. As a proof of concept, the membrane electrode assembly in single-cell PEMWE based on honeycomb-structured IrO x foam platelets, with a low iridium loading (~0.3 mg Ir /cm 2 ), is demonstrated to exhibit high catalytic activity at ampere-level current densities and to remain stable for more than 2000 hours.}, archive = {J_ANGEW}, author = {Zhoubing Xie and Hui Chen and Xiyang Wang and Yimin A. Wu and Zizhun Wang and Subhajit Jana and Yongcun Zou and Xiao Zhao and Xiao Liang and Xiaoxin Zou}, doi = {10.1002/anie.202415032}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415032}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Honeycomb-structured IrOx foam platelets as the building block of anode catalyst layer in PEM water electrolyzer}, volume = {64}, year = {2025}, }
• (2025). Chiral Au@CeO2 helical nanorods with spatially separated structures for polarization-dependent n2 photofixation. ANGEW, 64(3), e202415031. (www)

  @article{ , abstract = {Chiral photocatalytic nanomaterials possess numerous unique properties and hold promise for various applications in chemical synthesis, environmental protection, energy conversion, and photoelectric devices. Nevertheless, it is uncommon to develop effective means to enhance the asymmetric catalytic performances of chiral plasmonic nanomaterials. In this study, a type of L / D -Au@CeO 2 helical nanorods (HNRs) was fabricated by selectively growing CeO 2 on the surface of Au HNRs via a facile wet-chemistry construction method. Chiral Au@CeO 2 HNRs, featuring Au and CeO 2 with spatially separated structures, exhibited the highest photocatalytic performance for N 2 fixation, being 50.80±2.64 times greater than that of Au HNRs. Furthermore, when L -Au@CeO 2 HNRs were exposed to left circularly polarized light (CPL) and D -Au@CeO 2 HNRs were exposed to right CPL, their photocatalytic efficiency was enhanced by 3.06±0.06 times compared to the samples illuminated with the opposite CPL, which can be attributed to the asymmetrical generation of hot carriers upon CPL excitation. This study not only offers a simple approach to enhance the photocatalytic performance of chiral plasmonic nanomaterials but also demonstrates the potential of chiral plasmonic materials for application in specific photocatalytic reactions, such as N 2 fixation.}, archive = {J_ANGEW}, author = {Fang Wang and Weimin Yang and Qi Ding and Xinhe Xing and Liguang Xu and Hengwei Lin and Chuanlai Xu and Si Li}, doi = {10.1002/anie.202415031}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chiral Au@CeO2 helical nanorods with spatially separated structures for polarization-dependent n2 photofixation}, volume = {64}, year = {2025}, }
• (2025). Restricting linker rotation in nanocages of ZIF-8 membranes using crown ether “Molecular locks” for enhanced Propylene/Propane separation. ANGEW, 64(3), e202415023. (www)

  @article{ , abstract = {ZIF-8 membranes have long been prized for their exceptional C 3 H 6 /C 3 H 8 separation performance. On the other hand, ZIF-8 has structural flexibility, where the external pressure triggers channel expansion, potentially deteriorating the molecular sieving ability. Here, we demonstrate a reliable strategy to fine-tune the flexible pore structure of ZIF-8 by embedding crown ether within a ZIF-8 membrane. Benzo-15-crown-5 (15C5) was selected as the cavity occupant and perfectly confined in the sodalite (SOD) cage of ZIF-8. The 15C5 molecules, which have a size comparable to the nanocage, impose a spatial constraint on linker rotation, enabling the phase transition to a rigid structure in the flexible ZIF-8. The corresponding 15C5@ZIF-8 membranes achieve an ultrahigh C 3 H 6 /C 3 H 8 selectivity of 220, outperforming that of most membranes. Unlike their flexible counterparts, the resulting membranes manifest a positive increase in the C 3 H 6 /C 3 H 8 separation factor with elevated pressure, securing a record-high C 3 H 6 /C 3 H 8 separation factor of 331 under 7 bar. More importantly, extraordinary separation stability was demonstrated with continuous measurement, which is highly desirable for practical applications.}, archive = {J_ANGEW}, author = {Zinan Zhang and Han Zhu and Hua Jin and Yi Cao and Wei Fang and Zhenxin Zhang and Qiang Ma and Jungkyu Choi and Yanshuo Li}, doi = {10.1002/anie.202415023}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202415023}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Restricting linker rotation in nanocages of ZIF-8 membranes using crown ether “Molecular locks” for enhanced Propylene/Propane separation}, volume = {64}, year = {2025}, }
• (2025). Cleavage of the robust Silicon–Fluorine σ-bond allows Silicon–Carbon bond formation: Synthetic strategies toward ortho-silyl aryl phosphonates. ANGEW, 64(3), e202413759. (www)

  @article{ , abstract = {A straightforward, mild, and transition-metal-free three-component coupling reaction involving arynes, phosphites, and silyl fluorides was developed through Si−F bond activation. Although the Si−F bond is one of the strongest bonds, Si−C bond formation via Si−F bond cleavage with the assistance of bidentate silicon and phosphonium Lewis acids has been successfully achieved. This unprecedented strategy provides a facile approach for synthesizing ortho -silyl-substituted aryl phosphonates. Notably, this method allows the use of not only dialkylarylsilyl fluorides and diarylalkylsilyl fluorides but also triarylsilyl fluorides as coupling partners, which is uncommon in the field of arylsilane synthesis. Furthermore, a variety of ortho -silyl-substituted aryl phosphonates were produced in moderate to good yields with broad functional group tolerance. Additionally, the versatility of ortho -silyl-substituted aryl phosphonates was demonstrated by the elaboration of the products into a range of silicon-containing compounds.}, archive = {J_ANGEW}, author = {Suhyun Ji and Soomin Kim and Jae Kyun Lee and Duck-Hyung Lee and Seo-Jung Han}, doi = {10.1002/anie.202413759}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202413759}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cleavage of the robust Silicon–Fluorine σ-bond allows Silicon–Carbon bond formation: Synthetic strategies toward ortho-silyl aryl phosphonates}, volume = {64}, year = {2025}, }
• (2025). Proton intercalation into an open-tunnel bronze phase with near-zero volume change. ANGEW, 64(3), e202410971. (www)

  @article{ , abstract = {Managing safety and supply-chain risks associated with lithium-ion batteries (LIBs) is an urgent task for sustainable development. Aqueous proton batteries are attractive alternatives to LIBs because using water and protons addresses these two risks. However, most host materials undergo large volume changes upon H + intercalation, which induces intraparticle cracking to accelerates parasitic reactions. Herein, we report that Mo 3 Nb 2 O 14 bronze exhibits reversible H + intercalation (200 mAh g −1 ) with a Coulombic efficiency of 99.7 % owing to near-zero volume change and solid-solution-type phase transition. Combination of experimental and theoretical analyses clarifies that rotation and shrinkage of open tunnels, which consist of flexible corner-sharing Mo/NbO n polyhedra, relieve local structural distortions upon H + intercalation to suppress intraparticle cracking. The prototype full cell of an aqueous proton battery with a Mo 3 Nb 2 O 14 anode operates stably over 1000 charge/discharge cycles. This study reveals the importance of implementing distortion-relieving voids in host materials to reduce volume change upon charge/discharge.}, archive = {J_ANGEW}, author = {Kosuke Kawai and Seong-Hoon Jang and Yuta Igarashi and Koji Yazawa and Kazuma Gotoh and Jun Kikkawa and Atsuo Yamada and Yoshitaka Tateyama and Masashi Okubo}, doi = {10.1002/anie.202410971}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202410971}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proton intercalation into an open-tunnel bronze phase with near-zero volume change}, volume = {64}, year = {2025}, }
• (2025). Gapped and rotated grain boundary revealed in ultra-small au nanoparticles for enhancing electrochemical CO2 reduction. ANGEW, 64(3), e202410109. (www)

  @article{ , abstract = {Although gapped grain boundaries have often been observed in bulk and nanosized materials, and their crucial roles in some physical and chemical processes have been confirmed, their acquisition at ultrasmall nanoscale presents a significant challenge. To date, they had not been reported in metal nanoparticles smaller than 2 nm owing to the difficulty in characterization and the high instability of grain boundary (GB) atoms. Herein, we have successfully developed a synthesis method for producing a novel chiral nanocluster Au 78 (TBBT) 40 (TBBT=4-tert-butylphenylthiolate) with a 26-atom gapped and rotated GB. This nanocluster was precisely characterized using single-crystal X-ray crystallography and mass spectrometry. Additionally, an offset atomic defect linked to the peripheral Au(TBBT) 2 staple was found in the structure. Comparing it to similarly face-centered cubic-structured Au 36 (TBBT) 24 , Au 44 (TBBT) 28 , Au 52 (TBBT) 32 , Au 92 (TBBT) 44 , and ~5 nm nanocrystals, the bridging Au 78 (TBBT) 40 nanocluster exhibited higher catalytic activity in the electroreduction of CO 2 to CO. This enhanced activity was explained through density functional theory calculations and X-ray photoelectron spectroscopy analysis, which highlight the impact of GBs and point defects on the surface properties of metal nanoclusters in balancing intermediate adsorption and product desorption.}, archive = {J_ANGEW}, author = {Wenying Wang and Dong Chen and Victor Fung and Shengli Zhuang and Yue Zhou and Chengming Wang and Guoqing Bian and Yan Zhao and Nan Xia and Jin Li and Haiteng Deng and Lingwen Liao and Jun Yang and De-en Jiang and Zhikun Wu}, doi = {10.1002/anie.202410109}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {3}, pages = {e202410109}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gapped and rotated grain boundary revealed in ultra-small au nanoparticles for enhancing electrochemical CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: A double-walled noncovalent carbon nanotube by columnar packing of nanotube fragments. ANGEW, 64(2), e202580262. (www)

  @article{ , archive = {J_ANGEW}, author = {Daiki Imoto and Hiroki Shudo and Akiko Yagi and Kenichiro Itami}, doi = {10.1002/anie.202580262}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202580262}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: A double-walled noncovalent carbon nanotube by columnar packing of nanotube fragments}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Photo-triggered fluorescence polyelectrolyte nanoassemblies: Manipulate and boost singlet oxygen in photodynamic therapy. ANGEW, 64(2), e202580261. (www)

  @article{ , archive = {J_ANGEW}, author = {Yongkang Yao and Shangjun Chen and Chenxu Yan and Junyou Wang and Jianjun Liu and Wei-Hong Zhu and Chunhai Fan and Zhiqian Guo}, doi = {10.1002/anie.202580261}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202580261}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Photo-triggered fluorescence polyelectrolyte nanoassemblies: Manipulate and boost singlet oxygen in photodynamic therapy}, volume = {64}, year = {2025}, }
• (2025). Prince nana amaniampong. ANGEW, 64(2), e202422252. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202422252}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202422252}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Prince nana amaniampong}, volume = {64}, year = {2025}, }
• (2025). Structure prediction and computational protein design for efficient biocatalysts and bioactive proteins. ANGEW, 64(2), e202421686. (www)

  @article{ , abstract = {The ability to predict and design protein structures has led to numerous applications in medicine, diagnostics and sustainable chemical manufacture. In addition, the wealth of predicted protein structures has advanced our understanding of how life's molecules function and interact. Honouring the work that has fundamentally changed the way scientists research and engineer proteins, the Nobel Prize in Chemistry in 2024 was awarded to David Baker for computational protein design and jointly to Demis Hassabis and John Jumper, who developed AlphaFold for machine-learning-based protein structure prediction. Here, we highlight notable contributions to the development of these computational tools and their importance for the design of functional proteins that are applied in organic synthesis. Notably, both technologies have the potential to impact drug discovery as any therapeutic protein target can now be modelled, allowing the de novo design of peptide binders and the identification of small molecule ligands through in silico docking of large compound libraries. Looking ahead, we highlight future research directions in protein engineering, medicinal chemistry and material design that are enabled by this transformative shift in protein science.}, archive = {J_ANGEW}, author = {Rebecca Buller and Jiri Damborsky and Donald Hilvert and Uwe T. Bornscheuer}, doi = {10.1002/anie.202421686}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202421686}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structure prediction and computational protein design for efficient biocatalysts and bioactive proteins}, volume = {64}, year = {2025}, }
• (2025). Linli xu. ANGEW, 64(2), e202421616. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202421616}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202421616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Linli xu}, volume = {64}, year = {2025}, }
• (2025). Back cover: Target-templated construction of functional proteomimetics using photo-foldamer libraries (Angew. chem. int. ed. 2/2025). ANGEW, 64(2), e202421573. (www)

  @article{ , archive = {J_ANGEW}, author = {Edit Wéber and Péter Ábrányi-Balogh and Bence Nagymihály and Dóra K. Menyhárd and Nikolett Péczka and Márton Gadanecz and Gitta Schlosser and Zoltán Orgován and Ferenc Bogár and Dávid Bajusz and Gábor Kecskeméti and Zoltán Szabó and Éva Bartus and Attila Tököli and Gábor K. Tóth and Tibor V. Szalai and Tamás Takács and Elvin de Araujo and László Buday and András Perczel and Tamás A. Martinek and György M. Keserű}, doi = {10.1002/anie.202421573}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202421573}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Target-templated construction of functional proteomimetics using photo-foldamer libraries (Angew. chem. int. ed. 2/2025)}, volume = {64}, year = {2025}, }
• (2025). Cover picture: Accelerated reversible conversion of Li2S2 to Li2S by spidroin regulated li+ flux for high-performance li-sulfur batteries (Angew. chem. int. ed. 2/2025). ANGEW, 64(2), e202421572. (www)

  @article{ , archive = {J_ANGEW}, author = {Mingliang Liu and Zhen Wu and Shujun Liu and Tong Guo and Peng Chen and Xuan Cao and Shencheng Pan and Tianhong Zhou and Lea Pompizii and Murad Najafov and Ali Coskun and Yongsheng Fu}, doi = {10.1002/anie.202421572}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202421572}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cover picture: Accelerated reversible conversion of Li2S2 to Li2S by spidroin regulated li+ flux for high-performance li-sulfur batteries (Angew. chem. int. ed. 2/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Two-dimensional supramolecular polymorphism in cyanine H- and J-aggregates (Angew. chem. int. ed. 2/2025). ANGEW, 64(2), e202421491. (www)

  @article{ , archive = {J_ANGEW}, author = {Llorenç Rubert and Heike M. A. Ehmann and Bartolome Soberats}, doi = {10.1002/anie.202421491}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202421491}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Two-dimensional supramolecular polymorphism in cyanine H- and J-aggregates (Angew. chem. int. ed. 2/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Redox self-equilibration in molecular vanadium oxide mixtures enables multi-electron storage (Angew. chem. int. ed. 2/2025). ANGEW, 64(2), e202421488. (www)

  @article{ , archive = {J_ANGEW}, author = {Moritz Remmers and Boris Mashtakov and Stefan Repp and Alexandra Stefanie Jessica Rein and Ke Wang and Montaha Anjass and Zhengfan Chen and Luca M. Carrella and Eva Rentschler and Carsten Streb}, doi = {10.1002/anie.202421488}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202421488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Redox self-equilibration in molecular vanadium oxide mixtures enables multi-electron storage (Angew. chem. int. ed. 2/2025)}, volume = {64}, year = {2025}, }
• (2025). Vijay nair (1941–2024): A beacon of wisdom. ANGEW, 64(2), e202421461. (www)

  @article{ , archive = {J_ANGEW}, author = {R. S. Menon and A. T. Biju}, doi = {10.1002/anie.202421461}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202421461}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Vijay nair (1941–2024): A beacon of wisdom}, volume = {64}, year = {2025}, }
• (2025). Redox self-equilibration in molecular vanadium oxide mixtures enables multi-electron storage. ANGEW, 64(2), e202418864. (www)

  @article{ , abstract = {Polyoxometalates (POMs) are ideal components for reversible multi-electron storage in energy technologies. To-date, most redox-applications employ only single, individual POM species, which limits the number of electrons that can be stored within a given potential window. Here, we report that spontaneous redox self-equilibration during cluster synthesis leads to the formation of two structurally related polyoxovanadates which subsequently aggregate into co-crystals. This results in systems with significantly increased redox reactivity. The mixed POM system was formed by non-aqueous self-assembly of a vanadate precursor in the presence of Mg 2+ , resulting in two mixed-valent (V IV/V ) species, [(MgOH)V 13 O 33 Cl] 4− (= {MgV 13 } ) and the di-vanadium-functionalized species [V 14 O 34 Cl] 4− (= {V 14 } ), which co-crystallize in a 1 : 1 molar stoichiometry. Experimental data indicate that in the native state, {MgV 13 } is reduced by three electrons, and {V 14 } is reduced by five electrons. Electrochemical studies in solution show, that the system can reversibly undergo up to fourteen redox transitions (tentatively assigned to twelve 1-electron processes and two 2-electron processes) in the potential range between −2.15 V to +1.35 V (vs Fc + /Fc). The study demonstrates how highly redox-active, well-defined molecular mixtures of mixed-valent molecular metal oxides can be accessed by redox-equilibration during synthesis, opening new avenues for molecular energy storage.}, archive = {J_ANGEW}, author = {Moritz Remmers and Boris Mashtakov and Stefan Repp and Alexandra Stefanie Jessica Rein and Ke Wang and Montaha Anjass and Zhengfan Chen and Luca M. Carrella and Eva Rentschler and Carsten Streb}, doi = {10.1002/anie.202418864}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202418864}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox self-equilibration in molecular vanadium oxide mixtures enables multi-electron storage}, volume = {64}, year = {2025}, }
• (2025). Ligand assisted hydrogen bonding: A game-changer in lead passivation and stability in perovskite solar cells. ANGEW, 64(2), e202418763. (www)

  @article{ , abstract = {Lead halide perovskite solar cells (PSCs) have demonstrated power conversion efficiencies comparable to silicon-based solar cells, yet their instability under environmental stressors, such as humidity, heat, and light, remains a significant barrier to commercialization. A primary cause of this instability is the uncoordinated lead ions (Pb 2+ ), which accelerates the degradation of PSCs and pose environmental concerns due to potential lead leakage. Recently, the introduction of ligands into PSCs has shown promise in mitigating lead toxicity through effective passivation, primarily by forming hydrogen bonds (H-bonds) between functional groups of the ligands and the perovskite structure. In this minireview, we explore the critical role of H-bonds in stabilizing PSCs by enhancing the structural integrity of the perovskite layer and reducing lead leakage. Furthermore, we discuss the contribution of these ligands in defect passivation, hydrophobicity, self-encapsulation, cross-linking, and self-healing mechanisms. These insights will highlight the multi-functional capabilities of ligands in improving the long-term stability and durability of PSCs, offering pathways to address current challenges in their commercialization.}, archive = {J_ANGEW}, author = {Rida Ahmed and Sajidur Rehman and Zhiliang Chen and Feihong Ye and Xingang Ren}, doi = {10.1002/anie.202418763}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202418763}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand assisted hydrogen bonding: A game-changer in lead passivation and stability in perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Photon-driven dye induction pyroptosis: An emerging anti-tumor immunotherapy paradigm. ANGEW, 64(2), e202417899. (www)

  @article{ , abstract = {Photoimmunotherapy represents a novel and promising modality in anti-tumor immunotherapy, offering new hope in the realm of cancer treatment due to its distinctive mechanism and substantial therapeutic efficacy. This innovative approach synergistically integrates photon technology with immunological principles, utilizing photon energy to activate the body's immune response. Photon-driven pyroptosis, a pivotal element of photoimmunotherapy, has significantly revitalized the advancement of this discipline. To support this critical progress, this minireview offers an exhaustive examination of the organic dyes presently employed for photon-driven pyroptosis, alongside an analysis of the prevailing challenges and opportunities in dye molecule design. It is our aspiration that this minireview will contribute to the acceleration of developments in photon-driven pyroptosis dye and the broader field of photoimmunotherapy.}, archive = {J_ANGEW}, author = {Shuang Zeng and Jingyun Wang and Heemin Kang and Haidong Li and Xiaojun Peng and Juyoung Yoon}, doi = {10.1002/anie.202417899}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202417899}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photon-driven dye induction pyroptosis: An emerging anti-tumor immunotherapy paradigm}, volume = {64}, year = {2025}, }
• (2025). Accelerated reversible conversion of Li2S2 to Li2S by spidroin regulated li+ flux for high-performance li-sulfur batteries. ANGEW, 64(2), e202417624. (www)

  @article{ , abstract = {Regulating the transformation of sulfur species is the key to improving the electrochemical performance of lithium-sulfur (Li−S) batteries, in particular, to accelerate the reversible conversion between solid phase Li 2 S 2 and Li 2 S. Herein, we introduced Spidroin, which is a main protein in spider silk, as a dual functional separator coating in Li−S batteries to effectively adsorb polysulfides via the sequence of amino acids in its primary structure and regulate Li + flux through the β-sheet of its secondary structure, thus accelerating the reversible transformation between Li 2 S 2 and Li 2 S. Spidroin-based Li−S cells exhibited an exceptional electrochemical performance with a high specific capacity of 744.1 mAh g −1 at 5 C and a high areal capacity of 7.5 mAh cm −2 at a low electrolyte-to-sulfur (E/S) ratio of 6 μL mg s −1 and a sulfur loading of 8.6 mg s cm −2 .}, archive = {J_ANGEW}, author = {Mingliang Liu and Zhen Wu and Shujun Liu and Tong Guo and Peng Chen and Xuan Cao and Shencheng Pan and Tianhong Zhou and Lea Pompizii and Murad Najafov and Ali Coskun and Yongsheng Fu}, doi = {10.1002/anie.202417624}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202417624}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerated reversible conversion of Li2S2 to Li2S by spidroin regulated li+ flux for high-performance li-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Photo-triggered fluorescence polyelectrolyte nanoassemblies: Manipulate and boost singlet oxygen in photodynamic therapy. ANGEW, 64(2), e202416963. (www)

  @article{ , abstract = {Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post-PDT, and the limited photodynamic efficiency. Herein, we report a photo-triggered porphyrin polyelectrolyte nanoassembling (photo-triggered PPN) strategy, in which porphyrin photosensitizer and photoswitchable energy accepter are assembled into polyelectrolyte micelles by a combined force of charge interaction and metal-ligand coordination. The polyelectrolyte-based PPN exhibits good biocompatibility, and bestows a unique “confining isolated” inner microenvironment for fully overcoming the π–π stacking of porphyrins with significant photodynamic efficiency (123-fold enhancement). Due to the high Förster resonance energy transfer (FRET) (91.5 %) between porphyrin and photoswitch in closed-form, we could use light as a specific trigger to modulate photoswitch between closed- and open-form, and manipulate the 1 O 2 generation in three stages: pre-PDT (quenching 1 O 2 generation), during PDT (activating 1 O 2 generation), and post-PDT (silencing 1 O 2 generation). This de novo strategy has for the first time realized remotely manipulating and boosting 1 O 2 generation in PDT, well resolving the critical and general challenges of limited photodynamic efficiency and side effects from nonspecific phototoxicity.}, archive = {J_ANGEW}, author = {Yongkang Yao and Shangjun Chen and Chenxu Yan and Junyou Wang and Jianjun Liu and Wei-Hong Zhu and Chunhai Fan and Zhiqian Guo}, doi = {10.1002/anie.202416963}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202416963}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-triggered fluorescence polyelectrolyte nanoassemblies: Manipulate and boost singlet oxygen in photodynamic therapy}, volume = {64}, year = {2025}, }
• (2025). Cross-coupling of gaseous alkanes with (Hetero)Aryl bromides via dual Nickel/Photoredox catalysis. ANGEW, 64(2), e202416957. (www)

  @article{ , abstract = {Gaseous alkanes represent the most abundant carbon-based chemical feedstocks in our planet. However, the intrinsic inertness of their C−H bonds has rendered the use of these alkanes very difficult for purposes beyond aerobic combustion and energy intensive processes. Thus, clean and energy-efficient transformations for their use in synthetic organic chemistry are still rare. Here we report a catalytic methodology for the direct cross-coupling of gaseous alkanes with (hetero)aryl bromides through the combination of metallaphotoredox-mediated hydrogen atom transfer and nickel catalysis. This protocol provides an efficient platform for the addition of short alkyl groups into diverse (hetero) aromatic rings, providing a wide range of high-value alkyl(hetero)arenes, and bypassing the longstanding need of using preactivated alkylating agents in C (sp 2 ) -C (sp 3 ) cross-couplings. The method features high chemoselectivity, regioselectivity and a remarkable functional group tolerance, operates under mild conditions, and exhibits operational simplicity}, archive = {J_ANGEW}, author = {Akshay M. Nair and Pol Martínez-Balart and Sergio Barbeira-Arán and Martín Fañanás-Mastral}, doi = {10.1002/anie.202416957}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202416957}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cross-coupling of gaseous alkanes with (Hetero)Aryl bromides via dual Nickel/Photoredox catalysis}, volume = {64}, year = {2025}, }
• (2025). Emission library and applications of 2,1,3-benzothiadiazole and its derivative-based luminescent Metal–Organic frameworks. ANGEW, 64(2), e202416286. (www)

  @article{ , abstract = {Organic linker-based luminescent metal–organic frameworks (LMOFs) have received extensive attention due to their promising applications in chemical sensing, energy transfer, solid-state-lighting and heterogeneous catalysis. Benefiting from the virtually unlimited emissive organic linkers and the intrinsic advantages of MOFs, significant progress has been made in constructing LMOFs with specific emission behaviors and outstanding performances. Among these reported organic linkers, 2,1,3-benzothiadiazole and its derivatives, as unique building units with tunable electron-withdrawing abilities, can be used to synthesize numerous emissive linkers with a donor-bridge-acceptor-bridge-donor type structure. These linkers were utilized to coordinate with different metal nodes, forming LMOFs with diverse underlying nets and optical properties. In this Minireview, 2,1,3-benzothiadiazole and its derivative-based organic linkers and their corresponding LMOFs are summarized with which an emission library is built between the linker structures and the emission behaviors of constructed LMOFs. In particular, the preparation of LMOFs with customized emission properties ranging from deep-blue to near-infrared and sizes from dozens to hundreds of nanometers is discussed in detail. The applications of these LMOFs, including chemical sensing, energy harvesting and transfer, and catalysis, are then highlighted. Key perspectives and challenges for the future development of LMOFs are also addressed.}, archive = {J_ANGEW}, author = {Chao-Qin Han and Xiao-Yuan Liu}, doi = {10.1002/anie.202416286}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202416286}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Emission library and applications of 2,1,3-benzothiadiazole and its derivative-based luminescent Metal–Organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Better together: Photoredox/Copper dual catalysis in atom transfer radical polymerization. ANGEW, 64(2), e202415785. (www)

  @article{ , abstract = {Photomediated Atom Transfer Radical Polymerization (photoATRP) is an activator regeneration method, which allows for the controlled synthesis of well-defined polymers via light irradiation. Traditional photoATRP is often limited by the need for high-energy ultraviolet or violet light. These could negatively affect the control and selectivity of the polymerization, promote side reactions, and may not be applicable to biologically relevant systems. This drawback can be circumvented by an introduction of the catalytic amount of photocatalysts, which absorb visible and/or NIR light and, therefore, controlled, regenerative ATRP can be performed with the dual-catalytic cycle. Herein, a critical summary of recent developments in the field of dual-catalysis concerning Cu-catalyzed ATRP is provided. Contributions of involved species are examined mechanistically, followed by challenges and future directions towards the next generation of advanced functional macromolecular materials.}, archive = {J_ANGEW}, author = {Julian Sobieski and Adam Gorczyński and Arman Moini Jazani and Gorkem Yilmaz and Krzysztof Matyjaszewski}, doi = {10.1002/anie.202415785}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415785}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Better together: Photoredox/Copper dual catalysis in atom transfer radical polymerization}, volume = {64}, year = {2025}, }
• (2025). Two-dimensional supramolecular polymorphism in cyanine H- and J-aggregates. ANGEW, 64(2), e202415774. (www)

  @article{ , abstract = {We designed a new cyanine dye 1 , with two pedant rod-like groups, capable of forming two distinct two-dimensional (2D) supramolecular polymorphs in methylcyclohexane; an H-type aggregate ( Agg-H 2 ) and a J-type aggregate ( Agg-J ). Importantly, these two polymorphs were not accessed through polymerization events, and instead through the thermal transformation of a third particle-like polymorph ( Agg-H 1 ) formed by the anti-cooperative assembly of 1 . While Agg-H 2 is generated upon cooling the solution of Agg-H 1 by a thermoreversible polymorph transition, the Agg-J was obtained through a hidden pathway by combining sonication and cooling to the Agg-H 1 solution. This is the first report on the obtention of H- and J-type cyanine polymorphs that in turn could be isolated in solid-state to render two new 2D photoactive materials. This paper unveils new strategies for designing 2D supramolecular polymers using calamitic residues, but also undercovers relevant aspects of pathway complexity and polymorph transitions that might be crucial for developing novel photonic systems}, archive = {J_ANGEW}, author = {Llorenç Rubert and Heike M. A. Ehmann and Bartolome Soberats}, doi = {10.1002/anie.202415774}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415774}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-dimensional supramolecular polymorphism in cyanine H- and J-aggregates}, volume = {64}, year = {2025}, }
• (2025). Complexity-building exhaustive dearomatization of benzenoid aromatics within an ESIPT-initiated three-step photochemical cascade.. ANGEW, 64(2), e202415176. (www)

  @article{ , abstract = {Dearomative cycloadditions offer rapid access to complex 3D molecular architectures, commonly via a sp 2 -to-sp 3 rehybridization of two atoms of an aromatic ring. Here we report that the 6e π-system of a benzenoid aromatic pendant could be exhaustively depleted within a single photochemical cascade. An implementation of this approach involves the initial dearomative [4+2] cycloaddition of the Excited State Intramolecular Proton Transfer (ESIPT)-generated azaxylylene, followed by two consecutive [2+2] cycloadditions of auxiliary π moieties strategically positioned in the photoprecursor. Such photochemical cascade fully dearomatizes the benzenoid aromatic ring, saturating all six sp 2 atoms to yield a complex sp 3 -rich scaffold with high control of its 3D molecular shape, rendering it a robust platform for rapid systematic mapping of underexplored chemical space. Significant growth of molecular complexity—starting with a modular synthesis of photoprecursors from readily available building blocks—is quantified by Böttcher score calculations.}, archive = {J_ANGEW}, author = {Srinivas Beduru and Deepak B. Huple and Andrei G. Kutateladze}, doi = {10.1002/anie.202415176}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415176}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Complexity-building exhaustive dearomatization of benzenoid aromatics within an ESIPT-initiated three-step photochemical cascade.}, volume = {64}, year = {2025}, }
• (2025). Near-infrared light-driven CO2 reduction on cup-stacked carbon nanotubes. ANGEW, 64(2), e202415173. (www)

  @article{ , abstract = {Carbon nanotubes feature one-dimensional nature of collective excitations, wherein strong confinement of surface plasmons severely hinders the liberation of hot electrons (HEs), posing grand challenges for their utilization in photochemistry. In this study, we prototypically achieved directed HEs flow and extraction in hybrid plasmonic CNN based on cup-stacked carbon nanotubes (CSCNTs), taking advantage of their privileged edge-plane sites. The localized p z electronic states and accessible intersubband plasmon excitations in the near-infrared (NIR) regime stands in striking contrast to the conventional concentric carbon nanotubes, as evidenced by combined photo-induced force microscopy (PiFM) and transient photocurrent response. The hybrid comprising intimately integrated CSCNTs-C 3 N 4 effectively sustains interfacial electronic states and underlies the energy extraction out of plasmonic components. The CNN demonstrates almost near-unity NIR light-driven CO 2 reduction to CO with a rate of 1.35 μmol g −1 h −1 . This work sheds light on the exploitation of metal-free carbon-based plasmonic nanostructures for photocatalytic applications.}, archive = {J_ANGEW}, author = {Suchan Song and Cuncun Xin and Wei Liu and Wenzhe Shang and Tianna Liu and Wentao Peng and Jungang Hou and Yantao Shi}, doi = {10.1002/anie.202415173}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415173}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Near-infrared light-driven CO2 reduction on cup-stacked carbon nanotubes}, volume = {64}, year = {2025}, }
• (2025). Synthesis and characterization of monomeric triarylbismuthine oxide. ANGEW, 64(2), e202415169. (www)

  @article{ , abstract = {The synthesis and isolation of a bismuth-based analogue of the venerable triphenylphosphine oxide (Ph 3 PO) has remained a chimera to synthetic chemists for many years, due to its predicted high reactivity and instability. Through the hydrolysis of a cationic fluorotriarylbismuthonium(V) salt, we report here the isolation of unique hydroxytriarylbismuth(V) complexes, which served as precursor for the formation of the elusive monomeric triarylbismuthine oxide Dipp 3 Bi=O. Combined spectroscopic, crystallographic and computational studies provided insight into the bonding situation of the first monomeric triorganobismuth oxide complex. The Dipp 3 Bi=O and Mes 3 BiO⋅LiBAr F complex exhibits O-atom transfer reactivity, an uncommon reactivity feature for Ar 3 Pn=O.}, archive = {J_ANGEW}, author = {Jennifer Kuziola and Hye Won Moon and Markus Leutzsch and Nils Nöthling and Vanessa A. Béland and Josep Cornella}, doi = {10.1002/anie.202415169}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415169}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and characterization of monomeric triarylbismuthine oxide}, volume = {64}, year = {2025}, }
• (2025). Circularly polarized lasing from helical superstructures of chiral organic molecules. ANGEW, 64(2), e202415092. (www)

  @article{ , abstract = {Chiral supramolecular aggregates have the potential to explore circularly polarized lasing with large dissymmetry factors. However, the controllable assembly of chiral superstructures towards deterministic circularly polarized laser emission remains elusive. Here, we design a pair of chiral organic molecules capable of stacking into a pair of definite helical superstructures in microcrystals, which enables circularly polarized lasing with deterministic chirality and high dissymmetry factors. The microcrystals function as optical cavities and gain media simultaneously for laser oscillations, while the supramolecular helices endow the laser emission with strong and opposite chirality. As a result, the microcrystals of two enantiomers allow for circularly polarized laser emission with opposite chirality and high dissymmetry factors up to ~1.0. This work demonstrates the chiral supramolecular assemblies as an excellent platform for high-performance circularly polarized lasers.}, archive = {J_ANGEW}, author = {Shizhe Ren and Zheng-Fei Liu and Penghao Li and Haidi Liu and Miaosen Lu and Kang Wang and Jiannian Yao and Haiyun Dong and Qing-Zheng Yang and Yong Sheng Zhao}, doi = {10.1002/anie.202415092}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Circularly polarized lasing from helical superstructures of chiral organic molecules}, volume = {64}, year = {2025}, }
• (2025). Structural modulation of nanographenes enabled by defects, size and doping for oxygen reduction reaction. ANGEW, 64(2), e202415071. (www)

  @article{ , abstract = {Nanographenes are among the fastest-growing materials used for the oxygen reduction reaction (ORR) thanks to their low cost, environmental friendliness, excellent electrical conductivity, and scalable synthesis. The perspective of replacing precious metal-based electrocatalysts with functionalized graphene is highly desirable for reducing costs in energy conversion and storage systems. Generally, the enhanced ORR activity of the nanographenes is typically deemed to originate from the heteroatom doping effect, size effect, defects effect, and/or their synergistic effect. All these factors can efficiently modify the charge distribution on the sp 2 -conjugated carbon framework, bringing about optimized intermediate adsorption and accelerated electron transfer steps during ORR. In this review, the fundamental chemical and physical properties of nanographenes are first discussed about ORR applications. Afterward, the role of doping, size, defects, and their combined influence in boosting nanographenes’ ORR performance is introduced. Finally, significant challenges and essential perspectives of nanographenes as advanced ORR electrocatalysts are highlighted.}, archive = {J_ANGEW}, author = {Bin Wu and Haibing Meng and Xingbao Chen and Ying Guo and Li Jiang and Xiaofeng Shi and Jiexin Zhu and Juncai Long and Wenliang Gao and Feng Zeng and Wen-Jie Jiang and Yongfa Zhu and Dingsheng Wang and Liqiang Mai}, doi = {10.1002/anie.202415071}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415071}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structural modulation of nanographenes enabled by defects, size and doping for oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Polysilaketals: High-performance polyether-based electrolytes with tunable disubstituted silane linkers. ANGEW, 64(2), e202415069. (www)

  @article{ , abstract = {Polymer electrolytes exhibit higher energy density and improved safety in lithium-ion batteries relative to traditionally used liquid electrolytes but are currently limited by their lower electrochemical performance. Aiming to access polymer electrolytes with competitive electrochemical properties, we developed the anionic ring-opening polymerization (AROP) of cyclic silaketals to synthesize amorphous silicon-containing polyether-based electrolytes with varying substituent bulk of the general formula [OSi(R) 2 (CH 2 CH 2 O) 2 ] n (R=alkyl, phenyl). As opposed to previously reported uncontrolled polycondensation routes toward low molecular weight polysilaketals, AROP allows access to targeted molecular weights above the entanglement threshold of the polymers. The polysilaketal with the lowest steric bulk (P(OSi Me,Me -2EO)) exceeds the conductivity of poly(ethylene oxide) (PEO), a leading polymer electrolyte. To the best of our knowledge, this is the first solid polymer electrolyte to achieve this benchmark. Steric bulk in polysilaketals was found to impart stability and two bulkier polysilaketals, P(OSi Et,Et -2EO) and P(OSi Me,Ph -2EO), exhibited higher current fractions than PEO over a wide range of salt loadings. Moreover, the efficacy of P(OSi Et,Et -2EO) was competitive with that of PEO. Taken together, the tunable and competitive electrochemical properties of polysilaketals validate the systematic incorporation of silyl groups as a strategy to access high performance polymer electrolytes.}, archive = {J_ANGEW}, author = {Haley J. Rugh and Jaeyong Lee and Chenyue Sun and Emily E. Abdo and Juliana N. Bem and Nitash P. Balsara and Geoffrey W. Coates}, doi = {10.1002/anie.202415069}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polysilaketals: High-performance polyether-based electrolytes with tunable disubstituted silane linkers}, volume = {64}, year = {2025}, }
• (2025). Exploiting deep-ultraviolet nonlinear optical material Rb2ScB3O6F2 originated from congruously oriented [B3O6] groups. ANGEW, 64(2), e202415066. (www)

  @article{ , abstract = {The exploration and research for deep-ultraviolet (UV) nonlinear optical (NLO) crystals are of great significance for all-solid-state lasers. This work is based on the excellent structural [B 3 O 6 ] units which manipulate the excellent performances of famous commercial NLO crystal β -BaB 2 O 4 ( β -BBO) to explore new alternatives of deep-UV NLO materials. A deep-UV rare-earth metal borate fluoride Rb 2 ScB 3 O 6 F 2 (RSBF) is successfully designed by combining the heterovalent ions substitution strategy, and fluorination strategy. Expectedly, RSBF exhibits an extremely short cutoff edge below 175 nm (189 nm for β -BBO), and a moderate birefringence of 0.088 at 1064 nm. The shortest phase-matching (PM) wavelength of RSBF ( λ PM =182 nm) is shortened by 23 nm compared with β -BBO ( λ PM =205 nm) due to the improvements in the chromatic dispersion and cutoff edge, and an experimental frequency-doubling effect 1.4×KH 2 PO 4 (KDP) further suggests that RSBF can output a deep-UV harmonic laser. This work provides new sights from the original influencing factors for the rational and purposeful design of deep-UV NLO materials.}, archive = {J_ANGEW}, author = {Qianzhen Zhang and Ran An and Xifa Long and Zhihua Yang and Shilie Pan and Yun Yang}, doi = {10.1002/anie.202415066}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415066}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Exploiting deep-ultraviolet nonlinear optical material Rb2ScB3O6F2 originated from congruously oriented [B3O6] groups}, volume = {64}, year = {2025}, }
• (2025). Sequence-sensitivity in functional synthetic polymer properties. ANGEW, 64(2), e202415047. (www)

  @article{ , abstract = {Recently, a new class of synthetic methyl methacrylate-based random heteropolymers (MMA-based RHPs) has displayed protein-like properties. Their function appears to be insensitive to the precise sequence. Here, through atomistic molecular dynamics simulation, we show that there are universal protein-like features of MMA-based RHPs that are insensitive to the sequence, and mostly depend on the overall composition. In particular, we find that MMA-based RHPs “fold” into globules with heterogeneous hydration patterns. However, the insensitivity to sequence identity observed in MMA-based RHPs dramatically changes when we substitute the backbone architecture with acrylate or replace the oxygen atom in the side chain with a nitrogen atom (methacrylamide or acrylamide). In such scenarios, the sequence contributes significantly to the compactness and the hydration of monomers. Using principal component analysis and an intersection-over-union based index, we demonstrate that different sequences may not overlap in the property space, meaning that their properties are controlled by the sequence rather than fixed composition. We further investigate the sequence-insensitive capability of the MMA-based RHPs as previously reported on bacterial phospholipase OmpLA stabilization through heterodimerization. As experimentally observed, such polymers enhance the stability of OmpLA as reliably as its native bilayer environment. The design of such MMA-based RHPs provides a sequence-insensitive alternative to protein-mimetic biomaterials that is orthogonal to the sequence-structure-function paradigm of proteins.}, archive = {J_ANGEW}, author = {Tianyi Jin and Connor W. Coley and Alfredo Alexander-Katz}, doi = {10.1002/anie.202415047}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415047}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sequence-sensitivity in functional synthetic polymer properties}, volume = {64}, year = {2025}, }
• (2025). Enabling controllable time-dependent phosphorescence in carbonized polymer dots based on chromophore excited triplet energy level modulation by ionic bonding. ANGEW, 64(2), e202415042. (www)

  @article{ , abstract = {Time-dependent phosphorescence color (TDPC) materials are highly attractive for realizing multitiered dynamic information encryption and anti-counterfeiting. It's extremely challenging to modulate puzzle of multiple luminescence species and understand the intrinsic mechanism. Herein, we demonstrate a novel and synthesize-friendly strategy to develop a high contrast TDPC carbonized polymer dots (CPDs) with adjustable lifetime and quantum yields. The ionic bonding is introduced in self-protected CPDs to effectively tune the excited triplet energy level of chromophores, and promote the stable existence of L-aspartic (AA) with green phosphorescence at 545 nm, and alkali metal aspartates (AA–M) with red phosphorescence at 665 nm. The precise regulation for TDPC lifetime can be achieved based on heavy atom effort and crosslink-enhanced emission (CEE) effect. And, the efficient radiative energy transfer could be proven as an intrinsic mechanism for better understanding the TDPC materials. These results further expand on the fundamental principle to design high-quality TDPC materials with more flexible regulation for luminescence properties, providing a major step forward in broadening the scope of smart phosphorescence applications.}, archive = {J_ANGEW}, author = {Jie Sun and Yancen Liu and Yide Han and Wenhao Li and Nan Wang and Lin Zhang and Yu Zhang and Fuyao Deng and Dingsheng Wang and Xia Zhang}, doi = {10.1002/anie.202415042}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415042}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enabling controllable time-dependent phosphorescence in carbonized polymer dots based on chromophore excited triplet energy level modulation by ionic bonding}, volume = {64}, year = {2025}, }
• (2025). Ultrabroad near infrared emitting perovskites. ANGEW, 64(2), e202415003. (www)

  @article{ , abstract = {Phosphor converted light emitting diodes (pc-LEDs) have revolutionized solid-state white lighting by replacing energy-inefficient filament-based incandescent lamps. However, such a pc-LED emitting ultrabroad near-infrared (NIR) radiations still remains a challenge, primarily because of the lack of ultrabroad NIR emitting phosphors. To address this issue, we have prepared 2.5 % W 4+ -doped and 2.8 % Mo 4+ -doped Cs 2 Na 0.95 Ag 0.05 BiCl 6 perovskites emitting ultrabroad NIR radiation with unprecedented spectral widths of 434 and 468 nm, respectively. Upon band-edge excitation, the soft lattice of the host exhibits broad self-trapped exciton (STE) emission covering NIR-I (700 nm), which then nonradiatively excites the dopants. The –donor ligand Cl − reduces the energy of dopant d–d transitions emitting NIR-II with a peak at ~950 nm. Vibronic coupling broadens the dopant emission. The large spin-orbit coupling and local structural distortion might possibly enhance the dopant emission intensity, leading to an overall NIR photoluminescence quantum yield ~40 %. The composite of our ultrabroad NIR phosphors with biodegradable polymer polylactic acid could be processed into free-standing films and 3D printed structures. Large (170 170 ), robust, and thermally stable 3D printed pc-LED panels emit ultrabroad NIR radiation, demonstrating NIR imaging applications.}, archive = {J_ANGEW}, author = {Sajid Saikia and Animesh Gopal and Radha Rathod and Aprajita Joshi and K. R. Priolkar and Surajit Saha and Pralay K. Santra and Kadhiravan Shanmuganathan and Angshuman Nag}, doi = {10.1002/anie.202415003}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415003}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrabroad near infrared emitting perovskites}, volume = {64}, year = {2025}, }
• (2025). Ion-selective mobility differential amplifier: Enhancing pressure-induced voltage response in hydrogels. ANGEW, 64(2), e202415000. (www)

  @article{ , abstract = {Piezoionics is an emerging mechanical-electrical energy conversion paradigm that enables self-powered sensing systems for next-generation intelligent wearable electronics. However, there are currently no rational design approaches to enhance the stimulus response of piezoionic devices. Here, we present a strategy using crown ether as ion-selective mobility differential amplifiers for enhancing the pressure-induced voltage response in ionic polyvinyl alcohol (PVA) hydrogels. The crown ether grafted PVA (PVA-CE) hydrogel prototype achieves a 30-fold amplified piezoionic coefficient of 1490 nV Pa −1 within 0–1 kPa, compared to 49 nV Pa −1 of the unmodified PVA. The PVA-CE exhibits an ultra-low pressure detection limit of 0.2 Pa with a fast response time of 18.1 ms. Leveraging these properties, we further demonstrate arrayed pressure sensing with a PVA-CE piezoionic skin, analogous to the human somatosensory network. These capabilities hold great promises for emerging healthcare applications such as synthetic biology, soft robotics, and beyond.}, archive = {J_ANGEW}, author = {Kai Yang and Bolong Li and Zhihao Ma and Jiangang Xu and Dong Wang and Zhiheng Zeng and Derek Ho}, doi = {10.1002/anie.202415000}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202415000}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ion-selective mobility differential amplifier: Enhancing pressure-induced voltage response in hydrogels}, volume = {64}, year = {2025}, }
• (2025). Synthesis of non-canonical tryptophan variants via rh-catalyzed C−H functionalization of anilines. ANGEW, 64(2), e202414998. (www)

  @article{ , abstract = {Tryptophan and its non-canonical variants play critical roles in pharmaceutical molecules and various enzymes. Facile access to this privileged class of amino acids from readily available building blocks remains a long-standing challenge. Here, we report a regioselective synthesis of non-canonical tryptophans bearing C4−C7 substituents via Rh-catalyzed annulation between structurally diverse tert -butyloxycarbonyl (Boc)-protected anilines and alkynyl chlorides readily prepared from amino acid building blocks. This transformation harnesses Boc-directed C−H metalation and demetalation to afford a wide range of C2-unsubstituted indole products in a redox-neutral fashion. This umpolung approach compared to the classic Larock indole synthesis offers a novel mechanism for heteroarene annulation and will be useful for the synthesis of natural products and drug molecules containing non-canonical tryptophan residues in a highly regioselective manner.}, archive = {J_ANGEW}, author = {Jonathan Z. Huang and Vanessa Y. Ying and Mohammad R. Seyedsayamdost}, doi = {10.1002/anie.202414998}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414998}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of non-canonical tryptophan variants via rh-catalyzed C−H functionalization of anilines}, volume = {64}, year = {2025}, }
• (2025). Harnessing the synergistic interplay between atomic-scale vacancies and ligand effect to optimize the oxygen reduction activity and tolerance performance. ANGEW, 64(2), e202414989. (www)

  @article{ , abstract = {Defect engineering is an effective strategy for regulating the electrocatalysis of nanomaterials, yet it is seldom considered for modulating Pt-based electrocatalysts for the oxygen reduction reaction (ORR). In this study, we designed Ni-doped vacancy-rich Pt nanoparticles anchored on nitrogen-doped graphene (Vac-NiPt NPs/NG) with a low Pt loading of 3.5 wt . % and a Ni/Pt ratio of 0.038 : 1. Physical characterizations confirmed the presence of abundant atomic-scale vacancies in the Pt NPs induces long-range lattice distortions, and the Ni dopant generates a ligand effect resulting in electronic transfer from Ni to Pt. Experimental results and theoretical calculations indicated that atomic-scale vacancies mainly contributed the tolerance performances towards CO and CH 3 OH, the ligand effect derived from a tiny of Ni dopant accelerated the transformation from *O to *OH species, thereby improved the ORR activity without compromising the tolerance capabilities. Benefiting from the synergistic interplay between atomic-scale vacancies and ligand effect, as-prepared Vac-NiPt NPs/NG exhibited improved ORR activity, sufficient tolerance capabilities, and excellent durability. This study offers a new avenue for modulating the electrocatalytic activity of metal-based nanomaterials.}, archive = {J_ANGEW}, author = {Shenghua Ye and Wenda Chen and Zhijun Ou and Qinghao Zhang and Jie Zhang and Yongliang Li and Xiangzhong Ren and Xiaoping Ouyang and Lirong Zheng and Xueqing Yan and Jianhong Liu and Qianling Zhang}, doi = {10.1002/anie.202414989}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414989}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing the synergistic interplay between atomic-scale vacancies and ligand effect to optimize the oxygen reduction activity and tolerance performance}, volume = {64}, year = {2025}, }
• (2025). Dyotropic rearrangement of β-lactams: Reaction development, mechanistic study, and application to the total syntheses of tricyclic marine alkaloids. ANGEW, 64(2), e202414985. (www)

  @article{ , abstract = {An unprecedented dyotropic rearrangement of β-lactams has been developed, which provides an enabling tool for the synthesis of structurally diverse γ-butyrolactams. Unlike the well-established dyotropic rearrangements of β-lactones, the present reaction probably proceeds through a dual-activation mode, and thus displays unusual reactivity and chemoselectivity. The combined computational and experimental results suggest that the dyotropic rearrangement of β-lactams may proceed through different mechanisms depending on the nature of migrating groups (H, alkyl, or aryl). Hinging on a chemoselective H-migration dyotropic rearrangement of β-lactams, we have completed the divergent synthesis of tricyclic marine alkaloids (−)-lepadiformine A, (+)-cylindricine C, and (−)-fasicularin within 11–12 longest linear steps.}, archive = {J_ANGEW}, author = {Yunshan Li and Jingyang Zhang and Yi Chen and Jiahua Pang and Yuejie Chen and Yefeng Tang}, doi = {10.1002/anie.202414985}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414985}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dyotropic rearrangement of β-lactams: Reaction development, mechanistic study, and application to the total syntheses of tricyclic marine alkaloids}, volume = {64}, year = {2025}, }
• (2025). Conformation-confined organic butterfly-molecule with high photoluminescence efficiency, deep-blue amplified spontaneous emission, and unique piezochromic luminescence. ANGEW, 64(2), e202414960. (www)

  @article{ , abstract = {Organic fluorophores with tunable π-conjugated paths have attracted considerable attention owing to their diverse properties and promising applications. Herein, we present a tailored butterfly-like molecule, 2,2’-(2,5-bis (2,2-diphenylvinyl)-1,4-phenylene)dinaphthalene (BDVPN), which exhibits diverse photophysical features in its two polymorphs. The BP phase crystal, with its “aligned wings” conformation, possesses emissive characteristics that are nearly identical to those in dilute solutions. In contrast, the BN phase crystal, which adopts an “orthogonal wings” conformation, exhibits an unusual hypsochromic-shifted emission compared to its dilute solution counterparts. This intriguing hypsochromic-shifted emission originates from the reduction in the effective conjugated length of the molecular skeleton. Notably, BN phase crystals also exhibit exceptional optical performance, featuring high-efficiency emission (76.6 %), low-loss optical waveguides (0.571 dB mm −1 ), deep-blue amplified spontaneous emission (ASE) with narrow full width at half maximum (FWHM: 6.4 nm), and a unique 200 nm bathochromic shift of piezochromic luminescence.}, archive = {J_ANGEW}, author = {Shuting Dai and Xiao-Ze Li and Jiawen Liu and Chenchen Zhang and Jiasong Hu and Zhaoyang Liu and Hong-Hua Fang and Hong-Bo Sun and Bin Xu and Wenjing Tian}, doi = {10.1002/anie.202414960}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414960}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Conformation-confined organic butterfly-molecule with high photoluminescence efficiency, deep-blue amplified spontaneous emission, and unique piezochromic luminescence}, volume = {64}, year = {2025}, }
• (2025). Light-promoted extraction of precious metals using a porphyrin-integrated one-dimensional covalent organic framework. ANGEW, 64(2), e202414943. (www)

  @article{ , abstract = {Precious metals are valuable materials for the chemical industry, but they are scarce and pose a risk of supply disruption. Recycling precious metals from waste is a promising strategy, here we tactfully utilize light irradiation as an environmental-friendly and energy-saving adjunctive strategy to promote the reduction of precious metal ions, thereby improving the adsorption capacity and kinetics. A newly light-sensitive covalent organic framework (PP-COF) was synthesized to illustrate the effectiveness and feasibility of this light auxiliary strategy. The equilibrium adsorption capacities of PP-COF with light irradiation towards gold, platinum, and silver ions are 4729, 573, and 519 mg g −1 , which are 3.3, 1.9, and 1.2 times the adsorption capacities under dark condition. Significantly, a filtration column with PP-COF can recover more than 99.8 % of the gold ions in the simulated e-waste leachates with light irradiation, and 1 gram of PP-COF can recover gold from up to 0.15 tonne of e-waste leachates. Interestingly, the captured precious metals by PP-COF with light irradiation mainly exist in the micron-sized particles, which can be easily separated by extraction. We believe this work can contribute to precious metal recovery and circular economy for recycling resources.}, archive = {J_ANGEW}, author = {Yuan-Zhe Cheng and Xiaotian Bao and Di Jiang and Wenyan Ji and Dong-Hui Yang and Xuesong Ding and Xinfeng Liu and Yujian He and Bao-Hang Han}, doi = {10.1002/anie.202414943}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414943}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light-promoted extraction of precious metals using a porphyrin-integrated one-dimensional covalent organic framework}, volume = {64}, year = {2025}, }
• (2025). Self-resistance gene-guided discovery of the molecular basis for biosynthesis of the fatty acid synthase inhibitor cerulenin. ANGEW, 64(2), e202414941. (www)

  @article{ , abstract = {Cerulenin ( 1 ) is the first reported natural fatty acid synthase inhibitor and has been intensively researched for its antifungal, anticancer and anti-obesity properties. However, the molecular basis for its biosynthesis has remained a mystery for six decades. Here, we have identified the polyketide biosynthetic gene cluster ( cer ) responsible for the biosynthesis of 1 from two Sarocladium species using a self-resistance gene mining approach, which we validated via heterologous reconstitution of cer cluster in an Aspergillus nidulans host. Expression of various combinations of cer genes uncovered key pathway intermediates, electrocyclisation products derived from PKS-encoded polyenoic acids, and a suite of 13 new analogues of 1 . This enabled us to establish a biosynthetic pathway to 1 that starts with a C 12 polyketide precursor containing both E and Z double bonds and involves a complex series of epoxidations, double bond shifts, E / Z isomerisation and epoxide reduction. Using in vitro assays, we further validated the roles of amidotransferase CerD in amidation, and oxidase CerF and reductase CerE in the final two-electron oxidation and enone reduction steps towards 1 . These findings expand our understanding of complex tailoring modifications in highly reducing PKS pathways and pave the way for the engineered biosynthesis of cerulenin analogues.}, archive = {J_ANGEW}, author = {Zhuo Shang and Amr A. Arishi and Changzheng Wu and Fangzheng Lao and Cameron L. M. Gilchrist and Stephen A. Moggach and Ernest Lacey and Andrew M. Piggott and Yit-Heng Chooi}, doi = {10.1002/anie.202414941}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414941}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-resistance gene-guided discovery of the molecular basis for biosynthesis of the fatty acid synthase inhibitor cerulenin}, volume = {64}, year = {2025}, }
• (2025). Photocatalyzed aryl C-H fluorocarbonylation with CF2Br2. ANGEW, 64(2), e202414933. (www)

  @article{ , abstract = {The use of abundant and inexpensive fluorine feedstocks to synthesize fluorinated compounds is a promising strategy that has not been extensively investigated. Dibromodifluoromethane (CF 2 Br 2 ) is an inexpensive fluorine source that has rarely been used for C−H fluoroalkylation. This study reveals an iridium-catalyzed, tunable strategy for synthesizing acyl fluorides and difluorobromomethylated products using CF 2 Br 2 . To achieve the desired products, this process only requires the change of solvent (from DMSO to 1,4-dioxane) under blue LED illumination. A variety of arenes and heteroarenes with electron-donating substituents were successfully used, yielding the corresponding products in moderate to good yields. Mechanistic experiments revealed that DMSO served a dual role, functioning as both solvent and nucleophilic reagent in C−H fluorocarbonylation.}, archive = {J_ANGEW}, author = {Kehan Zhou and Yuheng Xiao and Zhibin Huang and Yingsheng Zhao}, doi = {10.1002/anie.202414933}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414933}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photocatalyzed aryl C-H fluorocarbonylation with CF2Br2}, volume = {64}, year = {2025}, }
• (2025). Directly regenerating of spent LiCoO2 with gradient F-doped subsurface towards ultra-stable storage properties. ANGEW, 64(2), e202414918. (www)

  @article{ , abstract = {As great potential recycling strategy, the direct regeneration of spent LiCoO 2 (LCO) is beneficial for lowering environmental pollutions and promoting global sustainability. However, owing to the using of binder and electrolyte, some fluorine impurities would be remained into spent materials. Considering the doping behaviors of F-elements, their suitable content introducing would facilitate the energy-storage abilities of regenerated LCO. Herein, through the tailored introduction of F-elements, spent LCO are successfully regenerated with physical-chemical evolutions. Benefitting from the existed oxygen vacancies, the diffusion energy-barrier of F-elements is reduced from 1.73 eV to 0.61 eV, facilitating the establishment of gradient F-doped subsurface, along with the formation of rigid CoO 5 F. Meanwhile, excess F-elements (1 wt %, as a threshold) lead to the formation of LiF passivation layer on the surface. Thus, the as-optimized sample displays a considerable capacity of 154.4 mAh g −1 even at 5.0 C, with retention rate (88.3 %) in 3.0–4.5 V. Supported by detailed electrochemical and kinetic analysis, the structural advantages are confirmed to boost the improved redox activity of Co-ions and the alleviating of irreversible oxygen-release. Give this, the work is anticipated to reveal the evolutions of regenerated LCO with the introduced F-elements, whilst providing the practical regeneration strategies toward excellent high-voltage properties.}, archive = {J_ANGEW}, author = {Hai Lei and Xinwei Cui and Zihao Zeng and Chao Zhu and Wei Sun and Yue Yang and Peng Ge}, doi = {10.1002/anie.202414918}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414918}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Directly regenerating of spent LiCoO2 with gradient F-doped subsurface towards ultra-stable storage properties}, volume = {64}, year = {2025}, }
• (2025). Encapsulation of an au25 nanocluster inside a porphyrin nanoring enhances singlet oxygen generation and photo-electrocatalytic CO2 reduction. ANGEW, 64(2), e202414908. (www)

  @article{ , abstract = {The synthesis of molecular host–guest complexes with enhanced performance, relative to those of their components, is a central theme in supramolecular chemistry. Here we explore a host-guest system consisting of an atomically precise gold nanocluster bound inside a zinc porphyrin nanoring. UV/Vis absorption and fluorescence titrations with different sized nanorings revealed strong binding between a pyridinethiol-coated Au 25 nanocluster and a nanoring consisting of six zinc porphyrin units, and complexation is confirmed by mass spectrometry. Formation of this assembly enhances the stability of the gold nanocluster. The host-guest complex also exhibits remarkable activity and selectivity for photochemical CO 2 to CO conversion and singlet oxygen generation.}, archive = {J_ANGEW}, author = {Abolfazl Ziarati and Henrik Gotfredsen and Arnulf Rosspeintner and Jiangtao Zhao and Harry L. Anderson and Thomas Bürgi}, doi = {10.1002/anie.202414908}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414908}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Encapsulation of an au25 nanocluster inside a porphyrin nanoring enhances singlet oxygen generation and photo-electrocatalytic CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Hybrid local and charge transfer emitters utilizing hyperconjugation effect towards solution-processed ultra-deep-blue OLEDs with external quantum efficiency approaching 12 %. ANGEW, 64(2), e202414905. (www)

  @article{ , abstract = {Hybrid local and charge transfer (HLCT) excited state materials, which possess weak donor-acceptor (D–A) pure organic structures, deserve one of the most promising efficient and stable blue emitters. Through high-lying reverse intersystem crossing (hRISC) process, 75 % triplet excitons generated by electrical excitation could be harvested and utilized in organic light-emitting diodes (OLEDs). However, there are still significant challenges to achieve high-efficiency ultra-deep-blue HLCT emitters with low Commission Internationale de l'Eclairage (CIE) 1931 chromaticity coordinate y values. Here, a series of novel blue HLCT emitters based on spiro[1,8-diazafluorene-9,2′-imidazole] structure were designed and synthesized by fine-tuning the spiro[fluorene-9,2′-imidazole] core structure in our previous work through heteroatom substitution and hyperconjugation effect. The target emitters were endowed with excellent photophysical and electrochemical merits, thermal stability and solution processibility. The solution-processed OLED based on 4′,5′-bis(4-(9 H -carbazol-9-yl)phenyl)spiro[1,8-diazafluorene-9,2′-imidazole] ( NFIP-CZ ) achieved efficient ultra-deep-blue emission (CIE x,y =0.1581, 0.0422) with the maximum external quantum efficiency (EQE max ), maximum current efficiency (CE max ) and maximum power efficiency (PE max ) of 11.94 %, 4.07 cd ⋅ A −1 and 2.56 lm ⋅ W −1 . The record EQE is a breakthrough in both solution-processed and vacuum vapor deposition ultra-deep-blue HLCT OLEDs currently.}, archive = {J_ANGEW}, author = {Chuanxin Liao and Shirong Wang and Bo Chen and Qi Xie and Jingyuan Feng and Jiaxu Bai and Xianggao Li and Hongli Liu}, doi = {10.1002/anie.202414905}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414905}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hybrid local and charge transfer emitters utilizing hyperconjugation effect towards solution-processed ultra-deep-blue OLEDs with external quantum efficiency approaching 12 %}, volume = {64}, year = {2025}, }
• (2025). Modulating the aggregation states of a Pd6L4 cage for selectivity flipping during the stereo-divergent semi-hydrogenation of alkynes. ANGEW, 64(2), e202414894. (www)

  @article{ , abstract = {An enzyme-mimicking catalytic system has been established using a singular palladium-based octahedral cage as the supramolecular reactor, deftly unlocking the off-on-off selectivity in the semi-hydrogenation of alkynes. Water serves as a critical regulator, modulating the catalyst states, reaction rates, and endpoints. The choice of solvent system influences the activity of host–guest binding and the reaction types of homogeneous and heterogeneous catalysis, effectively modifying the reaction steps involved in the Z → E isomerization during the semi-hydrogenation of alkynes. Kinetic and inhibition experiments indicate that the catalyst mimics the binding and activation characteristics of enzymes towards substrates, enabling selective transformations within the confined enzyme-mimicking environment. The utility of this switchable cage-confined catalysis has been demonstrated in the synthesis and modification of complex biologically active molecules with controllable E / Z selectivity. This work sheds light on the design and control of artificial supramolecular counterparts of enzymes, offering fundamental insights into the factors influencing the activity and catalytic selectivity of biological macromolecules.}, archive = {J_ANGEW}, author = {Zhong Wei and Xu Jing and Song Zhao and Yang Yang and Chunying Duan}, doi = {10.1002/anie.202414894}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414894}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating the aggregation states of a Pd6L4 cage for selectivity flipping during the stereo-divergent semi-hydrogenation of alkynes}, volume = {64}, year = {2025}, }
• (2025). Harnessing 4f electron itinerancy for integrated dual-band redox systems boosts lithium-oxygen batteries electrocatalysis. ANGEW, 64(2), e202414893. (www)

  @article{ , abstract = {In-depth comprehension and manipulation of band occupation at metal centers are crucial for facilitating effective adsorption and electron transfer in lithium-oxygen battery (LOB) reactions. Rare earth elements play a unique role in band hybridization due to their deep orbitals and strong localization of 4 f electrons. Herein, we anchor single Ce atoms onto CoO, constructing a highly active and stable catalyst with d - f a dual-band redox center. It is discovered that the itinerant behavior of 4 f electrons introduces an enhanced spin-orbit coupling effect, which facilitates ideal σ/π bonding and flexible adsorption between the Ce/Co active sites and *O. Simultaneously, the injection of localized Ce 4 f electrons strengthens the orbital bonding capacity of Co−O, effectively inhibits the dissolution of Co sites and improves the structural stability of the cathode material. Bracingly, the Ce 1 /CoO-based LOB exhibits an ultra-low charge–discharge polarization (0.46 V) and stable cyclic performance (1088 hours). This work breaks through the traditional limitations in catalyst activity and stability, providing new strategies and theoretical insights for developing high-performance LOBs powered by rare-earth elements.}, archive = {J_ANGEW}, author = {Mengyao Huang and Lina Song and Nan Wang and Yaning Fu and Rongchang Ren and Zhongjun Li and Youcai Lu and Jijing Xu and Qingchao Liu}, doi = {10.1002/anie.202414893}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414893}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing 4f electron itinerancy for integrated dual-band redox systems boosts lithium-oxygen batteries electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Two-coordinate Gold(I) complex with rotational freedom: A platform integrating thermally activated delayed fluorescence, polymorphism, and linearly polarized luminescence. ANGEW, 64(2), e202414892. (www)

  @article{ , abstract = {Two-coordinate coinage metal complexes have been exploited for various applications. Herein, a new donor-metal-acceptor (D–M–A) complex PZI-Au-TOT , using bulky pyrazine-fused N-heterocyclic carbene (PZI) and trioxytriphenylamine (TOT) ligands, was synthesized. PZI-Au-TOT displays decent thermally activated delayed fluorescence (TADF) with a quantum yield of 93 % in doped film. The crystals of PZI-Au-TOT show simultaneous TADF, polymorphism, and linearly polarized luminescence (LPL). The polymorph-dependent emission properties with widely varied peaks from 560 to 655 nm are attributed to different packing modes in terms of isolated monomers, discrete π–π stacked dimers or dimer PLUS. Two well-defined microcrystals of PZI-Au-TOT exhibit linearly polarized thermally activated delayed fluorescence with a degree of polarization up to 0.64. This work demonstrates that the molecular rotational flexibility of D–M–A type complexes endows an integration of multiple functions into one complex through manipulation of supramolecular aggregation. This type of complexes is expected to serve as a versatile platform for the fabrication of crystal materials for advanced photonic applications.}, archive = {J_ANGEW}, author = {Xi Zhang and Xiu-Fang Song and Shan Jiang and Yi-Ge Yao and Xiaoyong Chang and Yunan Gao and Kai Li and Yong Chen}, doi = {10.1002/anie.202414892}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414892}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-coordinate Gold(I) complex with rotational freedom: A platform integrating thermally activated delayed fluorescence, polymorphism, and linearly polarized luminescence}, volume = {64}, year = {2025}, }
• (2025). Stepwise one-shot borylation reactions for intersecting DABNA substructures exhibiting bright yellow-green electroluminescence with EQE beyond 40 % and mild roll-off. ANGEW, 64(2), e202414882. (www)

  @article{ , abstract = {Boron/nitrogen (B/N)-doped polycyclic aromatic hydrocarbons (PAHs) with the multiple resonance (MR) effect are promising for organic light-emitting diodes (OLEDs) because of their narrowband emission and thermally activated delayed fluorescence (TADF) characteristics. Nevertheless, exploring the variety of such emitters is challenging because of the tricky and limited synthetic protocols. Herein, we designed a novel B/N-doped PAH, L–DABNA-1, whose backbone (L–DABNA) could not be achieved via conventional routes (e.g., one-pot borylation or one-shot borylation). We successfully synthesized it through stepwise one-shot borylations with precisely introducing decorations. The unique MR backbone with intersecting DABNA substructures sharing an aniline group, avoiding any para-N-π-B motif, allows L–DABNA-1 to maintain narrowband TADF emission while significantly redshifting to the yellow-green region with a reverse intersystem crossing rate ( k RISC ) of 1.28×10 5 s −1 . An L–DABNA-1-based OLED device achieved a maximum external quantum efficiency (EQE) of over 40 % and maintained a high EQE of 36.3 % at 1000 cd m −2 , with a current efficiency reaching ~170 cd A −1 . This work not only demonstrated the great potential of stepwise borylations in synthesizing B/N-doped PAH backbones, expanding their chemical space, but also provided a promising pathway for exploring MR-TADF emitters at longer wavelengths.}, archive = {J_ANGEW}, author = {Xin Xiong and Ting-Feng Chen and Rajat Walia and Xiao-Chun Fan and Ying-Chun Cheng and Hui Wang and Hao Wu and Xian-Kai Chen and Jia Yu and Kai Wang and Xiao-Hong Zhang}, doi = {10.1002/anie.202414882}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414882}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stepwise one-shot borylation reactions for intersecting DABNA substructures exhibiting bright yellow-green electroluminescence with EQE beyond 40 % and mild roll-off}, volume = {64}, year = {2025}, }
• (2025). Facile synthesis of fe-based metal-quinone networks for mutually enhanced mild photothermal therapy and ferroptosis. ANGEW, 64(2), e202414879. (www)

  @article{ , abstract = {Mild photothermal therapy (MPTT) has emerged as a promising therapeutic modality for attenuating thermal damage to the normal tissues surrounding tumors, while the heat-induced upregulation of heat shock proteins (HSPs) greatly compromises the curative efficacy of MPTT by increasing cellular thermo-tolerance. Ferroptosis has been identified to suppress the overexpression of HSPs by the accumulation of lipid peroxides and reactive oxygen species (ROS), but is greatly restricted by overexpressed glutathione (GSH) in tumor microenvironment and undesirable ROS generation efficiency. Herein, a synergistic strategy based on the mutual enhancement of MPTT and ferroptosis is proposed for cleaving HSPs to recover tumor cell sensitivity. A facile method for fabricating a series of Fe-based metal-quinone networks (MQNs) by coordinated assembly is proposed and the representative FTP MQNs possess high photothermal conversion efficiency (69.3 %). Upon 808 nm laser irradiation, FTP MQNs not only trigger effective MPTT to induce apoptosis but more significantly, potentiate Fenton reaction and marked GSH consumption to boost ferroptosis, and the reinforced ferroptosis effect in turn can alleviate the thermal resistance by declining the HSP70 defense and reducing ATP levels. This study provides a valuable rationale for constructing a large library of MQNs for achieving mutual enhancement of MPTT and ferroptosis.}, archive = {J_ANGEW}, author = {Zhendong Liu and Sainan Liu and Bin Liu and Qi Meng and Meng Yuan and Xinyu Ma and Jiwei Wang and Meifang Wang and Kai Li and Ping'an Ma and Jun Lin}, doi = {10.1002/anie.202414879}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414879}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Facile synthesis of fe-based metal-quinone networks for mutually enhanced mild photothermal therapy and ferroptosis}, volume = {64}, year = {2025}, }
• (2025). Allylic epoxides increase the strain energy of cyclic olefin monomers for ring-opening metathesis polymerization. ANGEW, 64(2), e202414872. (www)

  @article{ , abstract = {Ring-opening metathesis polymerization (ROMP) is an effective method for synthesizing functional polymers, but since the technique typically relies on high ring strain cyclic olefins, the most common monomers are norbornene derivatives. The reliance on one class of monomer limits the obtainable properties of ROMP polymers. In this work, we investigate new bicyclic monomers synthesized via epoxidation of commercial dienes. DFT estimates of these monomers’ ring strains suggests a significant increase in strain for cyclic olefins containing allylic epoxides. We found that the eight-membered ( 3,4-COO ) and five-membered ( CPO ) cyclic olefins were particularly effective for ROMP. CPO was of especially intriguing due to its excellent polymerizability when compared to the limited reactivity of other five-membered rings. Unlike polynorbornenes, the resulting polymers of both monomers displayed glass transition temperatures well below room temperature. Interestingly, poly( 3,4-COO ) showed both high stereo- and regioregularity while poly( CPO ) showed little regularity. Both polymers could be readily modified via post-polymerization ring-opening of the reactive allylic epoxides. With a high epoxide density in poly( CPO ), CPO is an exciting new ROMP monomer that is easily synthesized, can be polymerized to high conversion at room temperature, and may be facilely modified to yield a wide range of functional materials.}, archive = {J_ANGEW}, author = {Kyle R. Sylvester and Jessa R. Zovinka and Maya L. Milrod and Alexandra K. Stubin and Angela Rojas-Merchan and Kayla Alexander and Benjamin R. Elling}, doi = {10.1002/anie.202414872}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Allylic epoxides increase the strain energy of cyclic olefin monomers for ring-opening metathesis polymerization}, volume = {64}, year = {2025}, }
• (2025). MPatch: A wearable hydrogel microneedle patch for in vivo optical sensing of calcium. ANGEW, 64(2), e202414871. (www)

  @article{ , abstract = {This study presents an in vivo optical hydrogel microneedle platform that measures levels of analytes in interstitial fluid. The platform builds on a previously published technique for molding hydrogel microneedles by developing a composite hydrogel (i.e., PEGDA and polyacrylamide) that is sufficiently stiff to penetrate skin in the hydrated state and whose fluorescence changes dynamically–via a conjugated aptamer–depending on level of analyte. In a demonstration relevant to hypercalcemia, the hydrogel microneedle distinguished varying concentrations of calcium (within a range of 0 to 2 mM, which spans physiologically meaningful variations for hypoparathyroidism) within 10 minutes. In rats, a compact CMOS sensor measuring fluorescence from microneedles distinguished low hypercalcemic (1.7 mM) from high hypercalcemic (2.3 mM) ionized calcium levels as determined from reference blood measurements. Overall, this work demonstrates in vivo feasibility of a concept–which we call mPatch–for an optical hydrogel microneedle to measure small changes in levels of analytes in interstitial fluid, which does not rely on extraction of interstitial fluid out of the dermis.}, archive = {J_ANGEW}, author = {Vira Behnam and Anika M. McManamen and Hannah G. Ballard and Bryan Aldana and Melissa Tamimi and Nenad Milosavić and Milan N. Stojanovic and Mishaela R. Rubin and Samuel K. Sia}, doi = {10.1002/anie.202414871}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414871}, shortjournal = {Angew. Chem. Int. Edit.}, title = {MPatch: A wearable hydrogel microneedle patch for in vivo optical sensing of calcium}, volume = {64}, year = {2025}, }
• (2025). Electrochemically gated frustrated lewis pair chemistry in electric double layer. ANGEW, 64(2), e202414867. (www)

  @article{ , abstract = {The recent discovery of frustrated Lewis pairs (FLPs) during the activation of small molecules has inspired extensive research across the full span of chemical science. Owing to the nature of weak interactions, it is experimentally challenging to directly observe and modulate FLP at the molecular scale. Here we design a boron cluster anion building block (B 10 H 8 2− ) and organic amine cations ([NR 4 ] + , R=−CH 3 , −C 2 H 5 ) as the FLP to prove the feasibility of controlling their interaction in the electric double layer (EDL) via an electrochemical strategy. In situ single-molecule electrical measurements and Raman monitoring of B 10 H 8 2− −[NR 4 ] + FLP formed at the positively charged Au(111) electrode surface, in contrast to the free-standing B 10 H 8 2− near or below the potential of zero charge (PZC). Furthermore, this FLP chemistry leads to a shift in the local density of states of boron clusters towards the E F for enhancing electron transport, providing a new prototype of a reversible single-cluster switch that digitally switches upon controlling FLP chemistry in the electric double layer.}, archive = {J_ANGEW}, author = {Hong-Yang Guo and Qiang Wan and Yunjia Jiang and Bo Wang and Lingyao Wang and Ju-Fang Zheng and Ya-Hao Wang and Yuanbin Zhang and Jian-Feng Li and Xiao-Shun Zhou}, doi = {10.1002/anie.202414867}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414867}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemically gated frustrated lewis pair chemistry in electric double layer}, volume = {64}, year = {2025}, }
• (2025). Selective methylation of cyclic ether towards highly elastic solid electrolyte interphase for silicon-based anodes. ANGEW, 64(2), e202414859. (www)

  @article{ , abstract = {Silicon (Si)-based anodes offer high theoretical capacity for lithium-ion batteries but suffer from severe volume changes and continuous solid electrolyte interphase (SEI) degradation. Here, we address these challenges by selective methylation of 1,3-dioxolane (DOL), thus shifting the unstable bulk polymerization to controlled interfacial reactions and resulting in a highly elastic SEI. Comparative studies of 2-methyl-1,3-dioxolane (2MDOL) and 4-methyl-1,3-dioxolane (4MDOL) reveal that 4MDOL, with its larger ring strain and more stable radical intermediates due to hyperconjugation effect, promotes the formation of high-molecular-weight polymeric species at the electrode-electrolyte interface. This elastic, polymer-rich SEI effectively accommodates volume changes of Si and inhibits continuous side reactions. Our designed electrolyte enables Si-based anode to achieve 85.4 % capacity retention after 400 cycles at 0.5 C without additives, significantly outperforming conventional carbonate-based electrolytes. Full cells also demonstrate stable long-term cycling. This work provides new insights into molecular-level electrolyte design for high-performance Si anodes, offering a promising pathway toward next-generation lithium-ion batteries with enhanced energy density and longevity.}, archive = {J_ANGEW}, author = {Zhihao Ma and Digen Ruan and Dazhuang Wang and Zongbin Lu and Zixu He and Jiasen Guo and Jiajia Fan and Jinyu Jiang and Zihong Wang and Xuan Luo and Jun Ma and Ze Zhang and Yezi You and Shuhong Jiao and Ruiguo Cao and Xiaodi Ren}, doi = {10.1002/anie.202414859}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414859}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective methylation of cyclic ether towards highly elastic solid electrolyte interphase for silicon-based anodes}, volume = {64}, year = {2025}, }
• (2025). Stereochemical impacts on acyclic mechanochemical carbon-carbon bond activation. ANGEW, 64(2), e202414849. (www)

  @article{ , abstract = {The influence of stereochemistry on the mechanochemistry rate is studied using a new mechanophore based on a benzopinacol (BP) skeleton. Two sets of BP diastereomers, the meso R,S and the R,R/S,S were isolated, incorporated into the center of a poly(methyl acrylate), and their mechanical activation rate was measured in solution. Under mechanical stress, the central C−C bond in BP is cleaved, providing two independent benzophenone molecules with higher UV-absorption coefficient at 254 nm. Monitoring the reaction rate spectroscopically indicates that the chiral R,R/S,S enantiomers react ~1.4 fold faster compared to the meso R,S diastereomer. In-silico modeling indicates that a hydrogen bond between the syn hydroxyls in the R,R diastereomer becomes shorter with stress, reducing the maximal force required for C−C bond scission, while this bond is inexistent in the meso diastereomer, as the hydroxyl are anti to each other. Our results indicate that in polymer where free rotation around bonds is possible, non-covalent interactions between backbone substituents, which are affected by relative stereochemistry, can play a fundamental role in the mechanochemical stability of the polymer.}, archive = {J_ANGEW}, author = {Rony Schwarz and Amit Manor Armon and Charles E. Diesendruck}, doi = {10.1002/anie.202414849}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414849}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereochemical impacts on acyclic mechanochemical carbon-carbon bond activation}, volume = {64}, year = {2025}, }
• (2025). Selective glycan presentation in liquid-ordered or -disordered membrane phases and its effect on lectin binding. ANGEW, 64(2), e202414847. (www)

  @article{ , abstract = {Glycan-protein interactions play a key role in various biological processes from fertilization to infections. Many of these interactions take place at the glycocalyx—a heavily glycosylated layer at the cell surface. Despite its significance, studying the glycocalyx remains challenging due to its complex, dynamic, and heterogeneous nature. This study introduces a glycocalyx model allowing for the first time to control spatial organization and heterogeneity of the glycan moieties. Glycan-mimetics with lipid-moieties that partition into either liquid-ordered (Lo, lipid rafts ) or liquid-disordered (Ld) phases of giant unilamellar vesicles (GUVs), which serve as simplified cell membrane models mimicking lipid rafts, are developed. This phase-specific allocation allows controlled placement of glycan motifs in distinct membrane environments, creating heteromultivalent systems that replicate the natural glycocalyx's complexity. We show that phase localization of glycan mimetics significantly influences recruitment of protein receptors to the membrane. Glycan-conjugates in the ordered phase demonstrate enhanced lectin binding, supporting the idea that raft-like domains facilitate stronger receptor interactions. This study provides a platform for systematically investigating spatial and dynamic presentation of glycans in biological systems and presents the first experimental evidence that glycan accumulation in lipid rafts enhances receptor binding affinity, offering deeper insights into the glycocalyx‘s functional mechanisms.}, archive = {J_ANGEW}, author = {Luca-Cesare Blawitzki and Cornelia Monzel and Stephan Schmidt and Laura Hartmann}, doi = {10.1002/anie.202414847}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414847}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective glycan presentation in liquid-ordered or -disordered membrane phases and its effect on lectin binding}, volume = {64}, year = {2025}, }
• (2025). Hydrogen bond-associated photofluorochromism for time-resolved information encryption and anti-counterfeiting. ANGEW, 64(2), e202414846. (www)

  @article{ , abstract = {Time-resolved photofluorochromism constitutes a powerful approach to enhance information encryption security but remains challenging. Herein, we report a strategy of using hydrogen bonds to regulate the time for initiating photofluorochromism. In our strategy, copolymers containing negative photochromic spiropyran (NSP), naphthalimide, and multiple hydrogen-bonding (UPy) units are designed, which display photo-switchable fluorescence resonance energy transfer (FRET) process from naphthalimide donor to the NSP acceptor. Interestingly, the FRET is locked via the dynamic hydrogen-bonding interaction between ring-opened NSP and UPy moieties, resulting in time-dependent fluorescence. The change in fluorescence can be finely regulated via UPy fraction in the polymers. Besides the novel time-dependent fluorescence, the polymers also take advantage of visible-light triggerable, excellent photostability, photoreversibility, and processability. We demonstrate that these properties enable them many application opportunities such as fluorescent security labels and multilevel information encryption patterns.}, archive = {J_ANGEW}, author = {Yuqian Xie and Xiaomei Zhao and Hong Wang and Yong Tian and Chunyang Liu and Jingmei Wu and Jiaxi Cui and Zhihua Zhou and Jian Chen and Xudong Chen}, doi = {10.1002/anie.202414846}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414846}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen bond-associated photofluorochromism for time-resolved information encryption and anti-counterfeiting}, volume = {64}, year = {2025}, }
• (2025). Targeted genome mining facilitates the discovery of a promiscuous, hyperthermostable amidase from thermovenabulum gondwanense with notable nylon-degrading capacity. ANGEW, 64(2), e202414842. (www)

  @article{ , abstract = {Plastics are ubiquitous in our ecosystems, and microplastic accumulation in the environment is an emerging global health concern. Since available recycling technologies are not economically competitive with primary plastic production, global use is expected to reach 1231 megatons by 2060, with 493 megatons leeching into the environment each year. To identify new nylon-recycling biotechnologies, targeted genome mining was used to identify thermostable enzymes capable of degrading polyamides. Here, we describe the characterization of a novel protein sourced from Thermovenabulum gondwanense : TvgC. TvgC is extremely stable, exhibiting a melting temperature of 93 °C and no detectable losses in hydrolytic activity after one week at 60 °C. While nylonases primarily process nylon-6, TvgC catalysed the degradation of both nylon-6 and nylon-6,6 films, which are considerably more difficult to degrade. Finally, conversion experiments demonstrate that TvgC achieves a 1.2 wt % conversion of nylon-6 film, comparable to that of the most highly engineered nylonases. This novel hyperthermostable protein represents an excellent starting point for future engineering of increasingly efficient nylonases.}, archive = {J_ANGEW}, author = {Esther R. Hoffman and Alana M. M. Rangaswamy and Maria E. Cleveland and Jeffrey W. Keillor and Graeme W. Howe}, doi = {10.1002/anie.202414842}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414842}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Targeted genome mining facilitates the discovery of a promiscuous, hyperthermostable amidase from thermovenabulum gondwanense with notable nylon-degrading capacity}, volume = {64}, year = {2025}, }
• (2025). The nature of structural defects in ZIF-8 revealed with 1H and 31P MAS NMR and X-ray absorption spectroscopy. ANGEW, 64(2), e202414823. (www)

  @article{ , abstract = {The metal–organic frameworks (MOFs) attract interest as potential catalysts whose catalytic properties are driven by defects. Several methods have been proposed for the defects-inducing synthesis of MOFs. However, the active species formed on the defective sites remain elusive and uncharacterized, as the spectroscopic fingerprints of these species are hidden by the regular structure signals. In this work, we have performed the synthesis of ZIF-8 MOF with defect-inducing procedures using fully deuterated 2-methylimidazolate ligands to enhance the defective sites′ visibility. By combining 1 H and 31 P MAS NMR spectroscopy and X-ray absorption spectroscopy, we have found evidence for the presence of different structural hydroxyl Zn−OH groups in the ZIF-8 materials. It is demonstrated that the ZIF-8 defect sites are represented by Zn−OH hydroxyl groups with the signals at 0.3 and −0.7 ppm in the 1 H MAS NMR spectrum. These species are of basic nature and may be responsible for the catalytic activity of the ZIF-8 material.}, archive = {J_ANGEW}, author = {Anton A. Gabrienko and Somboon Chaemchuen and Zongkui Kou and Naoki Ogiwara and Hiroshi Kitagawa and Alexander E. Khudozhitkov and Alexander G. Stepanov and Daniil I. Kolokolov and Francis Verpoort}, doi = {10.1002/anie.202414823}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414823}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The nature of structural defects in ZIF-8 revealed with 1H and 31P MAS NMR and X-ray absorption spectroscopy}, volume = {64}, year = {2025}, }
• (2025). Anomalous pressure-induced blue-shifted emission of ionic copper-iodine clusters: The competitive effect between cuprophilic interactions and through-space interactions. ANGEW, 64(2), e202414810. (www)

  @article{ , abstract = {Developing ionic copper-iodine clusters with multiple emitting is crucial for enriching lighting and display materials with various colors. However, the luminescent properties of traditional ionic copper-iodine clusters are often closely associated with low-energy cluster-centered triplet emission, which will redshift further as the Cu⋅⋅⋅Cu bond length decreases. This article utilizes a pressure-treated strategy to achieve an anomalous pressure-induced blue-shifted luminescence phenomenon in ionic Cu 4 I 6 (4-dimethylamino-1-ethylpyridinium) 2 crystals for the first time, which is based on dominant through-space charge-transfer (TSCT). Herein, we reveal that the more advantageous through-space interactions in the competition between cuprophilic interactions and through-space interactions can lead to a blue-shifted luminescence. High-pressure angle-dispersive X-ray diffraction and high-pressure infrared experiments show that the enhanced through-space interactions mainly originate from forming new intermolecular C−H⋅⋅⋅I hydrogen bonds and the enhancement of van der Waals interactions between organic cations and anionic clusters. Theoretical calculations and experimental studies of excited-state dynamics confirm that the blue-shifted emission is due to the increased energy gap between the excited triplet and ground states caused by the electron delocalization under stronger through-space interactions. This work deepens previous understanding and provides a new avenue to design and synthetic ionic copper-iodine clusters with high-energy TSCT emission.}, archive = {J_ANGEW}, author = {Shanshan Wang and Zhiqiang Yang and Xuening Sun and Min Wu and Kaiyang Sheng and Long Zhang and Bing Yang and Kai Wang and Yongming Sui and Bo Zou}, doi = {10.1002/anie.202414810}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414810}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anomalous pressure-induced blue-shifted emission of ionic copper-iodine clusters: The competitive effect between cuprophilic interactions and through-space interactions}, volume = {64}, year = {2025}, }
• (2025). Towards stable helical structures with enhanced molecular conductance by strengthening through-space conjugation. ANGEW, 64(2), e202414801. (www)

  @article{ , abstract = {Developing long-chain molecules with stable helical structures is of significant importance for understanding and modulating the properties and functions of helical biological macromolecules, but challenging. In this work, an effective and facile approach to stabilize folded helical structures by strengthening through-space conjugation is proposed, using new ortho -hexaphenylene ( o -HP) derivatives as models. The structure–activity relationship between the through-space conjugation and charge-transport behavior of the prepared folded helical o -HP derivatives is experimentally and theoretically investigated. It is demonstrated that the through-space conjugation within o -HP derivatives can be strengthened by introducing electron-withdrawing pyridine and pyrazine rings, which can effectively stabilize the helical structures of o -HP derivatives. Moreover, scanning tunneling microscopy-break junction measurements reveal that the stable regular helical structures of o -HP derivatives open-up dominant through-space charge-transport pathways, and the single-molecule conductance is enhanced by more than 70 % by strengthening through-space conjugation with pyridine and pyrazine. However, the through-bond charge transport pathways contribute much less to the conductance of o -HP derivatives. These results not only provide a new method for exploring stable helical molecules, but also provide a stepping stone for deciphering and modulating the charge-transport behavior of helical systems at the single-molecule level.}, archive = {J_ANGEW}, author = {Shaoshao Jiao and Pingchuan Shen and Jinshi Li and Xiaobin Dong and Ben Zhong Tang and Zujin Zhao}, doi = {10.1002/anie.202414801}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414801}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Towards stable helical structures with enhanced molecular conductance by strengthening through-space conjugation}, volume = {64}, year = {2025}, }
• (2025). Nucleophilic fluoride anion delivery from triazacyclononane-supported molecular Ca–F complexes. ANGEW, 64(2), e202414790. (www)

  @article{ , abstract = {The major source of fluoride, namely calcium difluoride (CaF 2 ), is derived from the mineral fluorspar. Recent advances in the activation of CaF 2 via mechanochemical methods have inspired investigation of the fundamental properties of Ca–F bonds in molecular complexes. However, the paucity of well-defined molecular Ca–F-containing complexes undermines systematic understanding of the factors governing nucleophilic fluoride delivery. Here we report the use of a multidentate bis(phenoxide) ligand based on a 1,4,7-triazacyclononane (TACN) scaffold for the formation of well-defined Ca–F complexes and demonstrate their capabilities in fluoride delivery. Key to this synthesis is a desymmetrization step carried out on the TACN ligand within the Ca coordination sphere. A series of stable anionic dinuclear calcium fluoride complexes has then been accessed and characterized by NMR spectroscopy (critically by 19 F NMR) and X-ray crystallography. Nucleophilic fluoride delivery can be used to generate C−F, Si–F and S−F bonds, with a notable advance over amide-derived ligand scaffolds being the reduced extent of side reactions derived from competing attack on the electrophile by the less nucleophilic O-donor anionic ligand set.}, archive = {J_ANGEW}, author = {Omar Apolinar and Job J. C. Struijs and Debotra Sarkar and Véronique Gouverneur and Simon Aldridge}, doi = {10.1002/anie.202414790}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nucleophilic fluoride anion delivery from triazacyclononane-supported molecular Ca–F complexes}, volume = {64}, year = {2025}, }
• (2025). Platinum-group metal high-entropy selenides for the hydrogen evolution reaction. ANGEW, 64(2), e202414786. (www)

  @article{ , abstract = {The selenides of platinum-group metals (PGMs) are emerging as promising catalysts for diverse electrochemical reactions. To date, most studies have focused on single metal or bimetallic systems, whereas the preparation of a high-entropy (HE) selenide consisting of five or more PGM elements holds the promise to further enhance catalytic performance by introducing abundant active sites with various local coordination environments and electronic structures. Herein, we report for the first time the synthesis of PGM-based HE-Selenide (HE-Se) nanoparticles with a unique amorphous structure. The atomic metal–Se coordination and the presence of short-range order were thoroughly revealed. It is further shown that the amorphous HE-Se can be facilely transformed into a single-phase crystalline HE-Se with a cubic structure by thermal annealing. Catalytically, the amorphous HE-Se showed better acidic hydrogen evolution activity over monometallic PGM-based selenides and the crystalline counterpart, demonstrating the advantages of high-entropy configuration and amorphous structure. Our findings may pave the way toward the synthesis and property exploration of amorphous PGM-based selenides with tunable compositions.}, archive = {J_ANGEW}, author = {Xiaohui Deng and Kohei Kusada and Tomokazu Yamamoto and Takaaki Toriyama and Yasukazu Murakami and Jo-Chi Tseng and Hiroki Yamada and Osami Sakata and Hirotaka Ashitani and Shogo Kawaguchi and Yoshiki Kubota and Hiroshi Kitagawa}, doi = {10.1002/anie.202414786}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Platinum-group metal high-entropy selenides for the hydrogen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Anion-anchored polymer-in-salt solid electrolyte for high-performance zinc batteries. ANGEW, 64(2), e202414777. (www)

  @article{ , abstract = {Solid polymer electrolytes hold promise for addressing key challenges in rechargeable zinc batteries (ZBs) utilizing aqueous electrolytes. However, achieving simultaneous high ionic conductivity, excellent mechanical strength, and a high cation transference number while effectively suppressing Zn dendrites remains challenging. Herein, we design a novel polymer-in-salt solid electrolyte (PISSE) composed of polyacrylonitrile (PAN), zinc chloride (ZnCl 2 ), and niobium pentoxide with oxygen vacancies (Nb 2 O 5-x ) with high ionic conductivity. PAN polymer matrix provides the electrolyte good mechanical properties and solubility of Zn salt. The high concentration of ZnCl 2 effectively decouples the Zn 2+ from polymer chain segments and provides more ionic conduction amorphous region. Moreover, incorporating Nb 2 O 5-x filler accelerates Zn 2+ desolvation by anchoring (Zn x Cl y ) 2x–y clusters and enhances the system's mechanical properties, achieving a superior Zn 2+ transference number (~0.93) and interfacial stability. Consequently, the optimized PISSE demonstrates exceptional stability during prolonged cycling periods, wide temperature range operation (−40 °C to 60 °C), remarkable flexibility, and compatibility with diverse electrode materials. This study provides valuable insights into the design of solid-state electrolytes based on ZBs and elucidates their multifunctional prospects.}, archive = {J_ANGEW}, author = {Xueru Shi and Yunpeng Zhong and Yongqiang Yang and Jiang Zhou and Xinxin Cao and Shuquan Liang}, doi = {10.1002/anie.202414777}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414777}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion-anchored polymer-in-salt solid electrolyte for high-performance zinc batteries}, volume = {64}, year = {2025}, }
• (2025). All-in-one polymer gel electrolyte towards high-efficiency and stable fiber zinc-air battery. ANGEW, 64(2), e202414772. (www)

  @article{ , abstract = {Fiber zinc-air batteries are explored as promising power systems for wearable and portable electronic devices due to their intrinsic safety and the use of ambient oxygen as cathode material. However, challenges such as limited zinc anode reversibility and sluggish cathode reaction kinetics result in poor cycling stability and low energy efficiency. To address these challenges, we design a polydopamine-based all-in-one gel electrolyte (PAGE) that simultaneously regulates the reversibility of zinc anodes and the kinetics of air cathodes through polydopamine interfacial and redox chemistry, respectively. The intrinsic catechol and carboxylate groups in PAGE regulate the transport and solvation structure of Zn 2+ , facilitating dendrite-free zinc deposition with a lamellar stacking morphology. Additionally, the oxidation of redox-active catechol groups in PAGE replaces the sluggish oxygen evolution reaction on the air cathode and reduces the energy barrier for charging, enabling fiber zinc-air batteries to achieve a significantly improved energy efficiency of 95 % and a longer lifespan of 40 hours. Further integration into self-powered electronic textiles underscores its potential for next-generation wearable systems.}, archive = {J_ANGEW}, author = {Zhe Yang and Pengzhou Li and Jiaxin Li and Chuanfa Li and Yanan Zhang and Taoyi Kong and Meng Liao and Tianbing Song and Jinyan Li and Peiyu Liu and Siwei Cao and Yonggang Wang and Peining Chen and Huisheng Peng and Bingjie Wang}, doi = {10.1002/anie.202414772}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {All-in-one polymer gel electrolyte towards high-efficiency and stable fiber zinc-air battery}, volume = {64}, year = {2025}, }
• (2025). A versatile metal-organic-framework pillared interlayer design for high-capacity and long-life lithium-sulfur batteries. ANGEW, 64(2), e202414770. (www)

  @article{ , abstract = {Developing high-performance lithium-sulfur batteries is a promising way to attain higher energy density at a lower cost beyond the state-of-the-art lithium-ion battery technology. However, the major issues impeding their practical applications are the sluggish kinetics and the parasitic shuttling reactions of sulfur and polysulfides. Here, pillaring the multilayer graphene membrane with a metal–organic framework (MOF) demonstrates the substantial impact of a versatile interlayer design in tackling these issues. Unlike regular composite separators reported so far, the participation of tri-metallic Ni−Co−Mn MOF as pillars supports the construction of an ion-channel interconnected interlayer structure, unexpectedly balancing the interfacial concentration polarization, spatially confining the soluble polysulfides, and vastly affording the lithiophilic sites for highly efficient polysulfide sieving/conversion. As a demonstration, we show that the MOF-pillared interlayer structure enables outstanding capacity (1634 mAh g −1 at 0.1 C) and longevity (average capacity decay of 0.034 % per cycle in 2000 cycles) for lithium-sulfur batteries. Besides, the multilayer separator can be readily integrated into the high-nickel cathode (LiNi 0.91 Mn 0.03 Co 0.06 O 2 )-based lithium-ion batteries, which efficiently suppresses the undesired phase evolution upon cycling. These findings suggest the potential of “gap-filling” materials in fabricating multi-functional separators, bringing forward the pillared interlayer structure for energy-storage applications.}, archive = {J_ANGEW}, author = {Peng Yang and Jun Qiang and Jiaqi Chen and Zhouyang Zhang and Ming Xu and Linfeng Fei}, doi = {10.1002/anie.202414770}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414770}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A versatile metal-organic-framework pillared interlayer design for high-capacity and long-life lithium-sulfur batteries}, volume = {64}, year = {2025}, }
• (2025). Customizing H2O-poor electric double layer and boosting texture exposure of zn (101) plane towards super-high areal capacity zinc metal batteries. ANGEW, 64(2), e202414757. (www)

  @article{ , abstract = {The catastrophic dendrite hyperplasia and parasitic reactions severely impede the future deployment of aqueous Zn-ion batteries. Controlling zinc orientation growth is considered to be an effective method to overcome the aforementioned concerns, especially for regulating the (002) plane of deposited Zn. Unfortunately, Zn (002) texture is difficult to obtain stable cycling under high deposition capacity resulting from its large lattice distortion and nonuniform distribution in electric field. Herein, different from traditional cognition, a crystallization orientation regulation tactic is proposed to boost Zn (101) texture exposure and inhibit zinc dendrite proliferation during plating/stripping. Experimental results and theoretical calculations demonstrate the malate molecules preferentially adsorb on the Zn (002) facet, leading to the texture exposure of distinctive Zn (101) plane. Meanwhile, the −COOH and −OH groups of malate molecules exhibit strong adsorption on the Zn anode surface and chelate with Zn 2+ , achieving H 2 O-poor electrical double layer. Very impressively, the multifunctional malate additive enlists zinc anode to survive for 600 h under a harsh condition of 15 mA cm −2 /15 mAh cm −2 . Moreover, the symmetric cell harvests highly-reversible cycling life of 6600 h at 5 mA cm −2 /1.25 mAh cm −2 , remarkably outperforming the ZnSO 4 electrolyte. The assembled Zn//MnO 2 full cells also demonstrate prominent electrochemical reversibility.}, archive = {J_ANGEW}, author = {Yangyang Wang and Jiaxin Lv and Laixin Hong and Jiakai Zhang and Chunxia Chen and Ao Xu and Miao Huang and Xiubin Ren and Jinbo Bai and Hui Wang and Xiaojie Liu}, doi = {10.1002/anie.202414757}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414757}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Customizing H2O-poor electric double layer and boosting texture exposure of zn (101) plane towards super-high areal capacity zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Multivalent weak protections ultimately enable customizable DNA grafting on pristine ag colloids for nanoplasmonics. ANGEW, 64(2), e202414752. (www)

  @article{ , abstract = {Silver nanoparticles (AgNPs) have superior plasmonic properties surpassing other metals. However, a long-standing difficulty in valence/density-tunable DNA grafting of AgNPs disfavors their use in DNA-directed nanoplasmonics. Herein a close-to-ideal surface protection of pristine AgNPs against various notorious stability issues of Ag is achieved based on multidentate weak nucleobase bindings of non-programming FSDNA (fish sperm DNA). This further allows grafting of thiolated DNA with tunable valence/density on AgNPs. The end-on format of the thiolated DNA grafts and the very thin FSDNA layer benefit DNA hybridization and plasmon coupling, respectively. Significantly promoted optical coupling and Raman enhancing are achieved. The compatibility of FSDNA-capped AgNPs with Au enables DNA-bonded symmetry-broken Au−Ag heterodimers with strong near-field coupling and an easily seen Fano-induced feature. Our work provides a treasured freedom of using AgNPs in DNA-programmed, better-behaving plasmonic devices.}, archive = {J_ANGEW}, author = {Lei Song and Xiaojun Song and Yanjuan Li and Yan Hao and Song Wang and Zhaoxiang Deng}, doi = {10.1002/anie.202414752}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414752}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multivalent weak protections ultimately enable customizable DNA grafting on pristine ag colloids for nanoplasmonics}, volume = {64}, year = {2025}, }
• (2025). Calibrating the oxidative capacity of microdroplets. ANGEW, 64(2), e202414746. (www)

  @article{ , abstract = {Recently, redox chemical transformations have been reported to occur spontaneously in microdroplets. The origins of such novel reactivity are still debated, and any systematic correlation of the oxidative/reductive yield with the reactivity of the reactant is yet to be established. Towards this end, we report the simple, outer-sphere, one-electron oxidation of a series of ferrocene derivatives spanning a range of oxidation potentials from −0.1 V to +0.8 V vs. Ag/AgCl in acetonitrile microdroplets generated via nebulization and measured by mass spectrometry of the corresponding ferrocenium ions. The reaction environments and dynamics in the droplets are complex, and it is still unclear whether such reactivity correlates with any bulk thermodynamic values. Our key finding is that the ion yields decrease monotonically with the oxidation potential of the ferrocenes, which is a thermodynamic quantity. The ion yields emphatically do not obey the Nernstian ratio, revealing the redox processes in the droplets do not follow the assumptions of bulk steady-state electrochemistry. Furthermore, oxidative competition in the mixture of several ferrocenes suggest a finite oxidative capacity or oxidant concentration. These results demonstrate that even though ion generation could be an out-of-equilibrium and kinetically limited process, the oxidative yield in microdroplets does correlate with thermodynamics, suggesting a possible free energy relationship between the kinetics and thermodynamics of the process.}, archive = {J_ANGEW}, author = {Tirthick Majumder and Dmitry B. Eremin and Berk Delibas and Archishman Sarkar and ValeryV. Fokin and Jahan M. Dawlaty}, doi = {10.1002/anie.202414746}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414746}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Calibrating the oxidative capacity of microdroplets}, volume = {64}, year = {2025}, }
• (2025). Triplet-sensitized switching of high-energy-density norbornadienes for molecular solar thermal energy storage with visible light. ANGEW, 64(2), e202414733. (www)

  @article{ , abstract = {Norbornadiene-based photoswitches have emerged as promising candidates for harnessing and storing solar energy, holding great promise as a viable solution to meet the growing energy demands. Despite their potential, the effectiveness of their direct photochemical conversion into the resulting quadricyclanes has room for improvement owing to (i) moderate quantum yields, (ii) poor overlap with the solar spectrum and (iii) photochemical back reactions. Herein, we present an approach to enhance the performance of such molecular solar thermal energy storage (MOST) systems through the triplet-sensitized conversion of aryl-substituted norbornadienes. Our study combines deep spectroscopic analyses, irradiation experiments, and quantum mechanical calculations to elucidate the energy transfer mechanism and inherent advantages of the resulting MOST systems. We demonstrate remarkable quantum yields using readily available sensitizers under both LED and solar light irradiation, significantly surpassing those achieved through direct excitation with photons of higher energy. In contrast to the conventional approach, light-induced back reactions of the high-energy products do not play any role, allowing quantitative switching within minutes. These results not only underscore the potential of triplet-sensitized MOST systems to leverage the high energy storage capabilities of multistate photoswitches but they might also stimulate the broader usage of sensitization strategies in photochemical energy conversion.}, archive = {J_ANGEW}, author = {Till J. B. Zähringer and Nico Perez Lopez and Robin Schulte and Matthias Schmitz and Heiko Ihmels and Christoph Kerzig}, doi = {10.1002/anie.202414733}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414733}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triplet-sensitized switching of high-energy-density norbornadienes for molecular solar thermal energy storage with visible light}, volume = {64}, year = {2025}, }
• (2025). Ternary eutectic electrolyte for flexible wide-temperature zinc-ion batteries from −20 °C to 70 °C. ANGEW, 64(2), e202414728. (www)

  @article{ , abstract = {Aqueous Zn-ion batteries (ZIBs) have attracted attention for grid applications due to their cost-effectiveness and high security. However, their lifespan decreases at high temperatures due to declining interfacial stability and increased side reactions. To address these challenges, a ternary deep eutectic solvent-based flexible electrolyte, comprised of Zn(ClO 4 ) 2 ⋅ 6H 2 O, butanedinitrile (BD), and LiCl in an amphoteric polymer matrix, was developed to enable wide-temperature ZIBs working from −20 °C to 70 °C. The interactions among BD, Li + , and zinc hydrate alongside the amphoteric groups on the polyelectrolyte matrix could effectively suppress the interfacial side reactions and Zn dendrites formation. Consequently, the symmetric Zn cell demonstrates exceptional stability across a wide-temperature range, with the ability to survive up to 2780 hours (1 mA cm −2 ) at 50 °C. Furthermore, the flexible Zn||PANI battery can operate stably over 1000 cycles at 50 °C, boasting an initial specific capacity of 124.8 mAh g −1 and capacity retention rate of 87.9 % (3 A g −1 ). This work presents an effective strategy for designing high-stability energy storage devices with excellent security features that can function reliably across diverse temperature conditions.}, archive = {J_ANGEW}, author = {Qinbo Liu and Junfu Li and Doudou Xing and Yingjie Zhou and Feng Yan}, doi = {10.1002/anie.202414728}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414728}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ternary eutectic electrolyte for flexible wide-temperature zinc-ion batteries from −20 °C to 70 °C}, volume = {64}, year = {2025}, }
• (2025). Chemoselective construction of polycyclic heterocycles containing a [6-6-5] or [7-6-5] tricyclic core skeleton from a 2-isocyanophenyl propargylic ester. ANGEW, 64(2), e202414726. (www)

  @article{ , abstract = {Functionalized isocyanide chemistry represents an important research area in organic synthesis. A structurally unique 2-isocyanophenyl propargylic ester has been designed to incorporate the reactivity of isocyanide and propargylic ester functionalities. Thus, the reaction of 2-isocyanophenyl propargylic ester and 2-aminoaromatic aldimine facilitates the synthesis of a wide range of polycyclic benzo[b] indolo [3,2-h][1,6] naphthyridine derivatives. Furthermore, reaction with 2-hydroxyaromatic aldimine enables the divergent synthesis of both the aforementioned scaffolds and structurally distinct diazabenzo [ f ] naphtho[2,3,4- ij ] azulenes featuring a [7-6-5] core skeleton. Experimental results and DFT calculations suggest that these transformations likely proceed by the in situ generation of a strained cyclopropenimine species followed by [3+2] cycloaddition. Next, switchable nucleophilic attack/ring expansion/aromatization and nucleophilic addition/ring expansion/elimination account for the observed selectivity.}, archive = {J_ANGEW}, author = {Youwen Fei and Zihao Zhou and Zihan Ni and Xin Peng and Lei Cui and Zijun Zhou and Xinyao Li and Chunju Li and Xueshun Jia and Jian Li}, doi = {10.1002/anie.202414726}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414726}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chemoselective construction of polycyclic heterocycles containing a [6-6-5] or [7-6-5] tricyclic core skeleton from a 2-isocyanophenyl propargylic ester}, volume = {64}, year = {2025}, }
• (2025). The paradoxical influence of hydrothermally treated zeolites on the hydrocarbon pool mechanism. ANGEW, 64(2), e202414724. (www)

  @article{ , abstract = {Understanding the mechanistic intricacies of hydrothermally treated zeolite is crucial for valorizing any oxygen-containing renewable feedstocks (e. g., methanol, carbon dioxide, biomass). Additionally, the regeneration of deactivated zeolite catalysts under oxidative conditions, akin to hydrothermal treatment, is essential in industrial processes. While research in this area has predominantly focused on characterizing steaming-induced physicochemical changes in zeolite, their ultimate impact on the organic reaction mechanism governed by the hydrocarbon pool dual-cycle mechanism remains unclear. To bridge this knowledge gap, this study investigates the effect of steamed zeolite on the organic reaction mechanism during the industrially significant methanol-to-hydrocarbons process. We achieved this objective by strategically integrating catalytic and control experiments over the pristine and steamed zeolites and their advanced characterization, including under operando conditions, XRD structural refinement, and using “mobility-dependent” solid-state NMR spectroscopy. This multimodal characterization approach was instrumental in elucidating elusive mechanistic information in the dual-cycle mechanism, shedding light on phenomena such as the unchanged ethylene selectivity despite decreasing aromatics selectivity, while ethylene could solely be derived from arene-based reaction intermediates. This study could improve the process efficiency in zeolite catalysis by connecting steaming-induced changes in the organic reaction mechanisms with inorganic material aspects.}, archive = {J_ANGEW}, author = {Xuan Gong and Shican Jiang and Alla Dikhtiarenko and Stefan Adrian F. Nastase and Edy Abou-Hamad and Yiru Ye and Hexun Zhou and Xinyu You and Rushana Khairova and Javier Patarroyo and Luigi Cavallo and Jorge Gascon and Abhishek Dutta Chowdhury}, doi = {10.1002/anie.202414724}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414724}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The paradoxical influence of hydrothermally treated zeolites on the hydrocarbon pool mechanism}, volume = {64}, year = {2025}, }
• (2025). Frustrated lewis pair mediated f-p-d orbital coupling: Achieving selective seawater oxidation and breaking *OH and *OOH scaling relationship. ANGEW, 64(2), e202414721. (www)

  @article{ , abstract = {The development of oxygen evolution reaction (OER) electrocatalyst for seawater electrolysis plays a crucial role in producing renewable hydrogen energy. However, during the seawater electrolysis process, the anode inevitably undergoes chloride oxidation reaction (ClOR) due to Cl − adsorption, making the seawater electrolysis process difficult to sustain. Inspired by the selective permeability of cell membranes, we propose a biomimetic design of frustrated Lewis pairs (FLPs) layers for selective seawater oxidation. Combining experimental results and molecular dynamics simulations, it has been demonstrated that cerium dioxide layers with FLPs sites can decompose water molecules, capture hydroxyl anions, and repel chloride ions simultaneously. DFT theoretical analysis indicates that the FLP sites regulate the Ce 4 f−O 2p−Ni 3d gradient orbital coupling, providing additional oxygen non-bonding (O NB ) to stabilize the Ni−O bond and optimize the adsorption strength of intermediates, thereby breaking the *OH and *OOH scaling relationship. The assembled anion exchange membrane electrolyzers exhibit an efficiency of 95.7 % at a current density of 0.1 A cm −2 and can stably operate for 250 hours at a current density of 0.2 A cm −2 .}, archive = {J_ANGEW}, author = {Jiawei Zhu and Tong Cui and Jingqi Chi and Tiantian Wang and Lili Guo and Xiaobin Liu and Zexing Wu and Jianping Lai and Lei Wang}, doi = {10.1002/anie.202414721}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414721}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frustrated lewis pair mediated f-p-d orbital coupling: Achieving selective seawater oxidation and breaking *OH and *OOH scaling relationship}, volume = {64}, year = {2025}, }
• (2025). Molybdenum disulfide induced phase control synthesis of multi-dimensional Co3S4-MoS2 heteronanostructures via cation exchange. ANGEW, 64(2), e202414720. (www)

  @article{ , abstract = {Phase control over cation exchange (CE) reactions has emerged as an important approach for the synthesis of nanomaterials (NMs), enabling precise determination of their reactivity and properties. Although factors such as crystal structure and morphology have been studied for the phase engineering of CE reactions in NMs, there remains a lack of systematic investigation to reveal the impact for the factors in heterogeneous materials. Herein, we report a molybdenum disulfide induced phase control method for synthesizing multidimensional Co 3 S 4 -MoS 2 heteronanostructures (HNs) via cation exchange. MoS 2 in parent Cu 1.94 S-MoS 2 HNs are proved to affect the thermodynamics and kinetics of CE reactions, and facilitate the formation of Co 3 S 4 -MoS 2 HNs with controlled phase. This MoS 2 induced phase control method can be extended to other parent HNs with multiple dimensions, which shows its diversity. Further, theoretical calculations demonstrate that Co 3 S 4 (111)/MoS 2 (001) exhibits a higher adhesion work, providing further evidence that MoS 2 enables phase control in the HNs CE reactions, inducing the generation of novel Co 3 S 4 -MoS 2 HNs. As a proof-of-concept application for crystal phase- and dimensionality-dependent of cobalt sulfide based HNs, the obtained Co 3 S 4 -MoS 2 heteronanoplates (HNPls) show remarkable performance in hydrogen evolution reactions (HER) under alkaline media. This synthetic methodology provides a unique design strategy to control the crystal structure and fills the gap in the study of heterogeneous materials on CE reaction over phase engineering that are otherwise inaccessible.}, archive = {J_ANGEW}, author = {Yu-Qing He and Hou-Ming Xu and Jian-Ding Zhang and Dong Zheng and Gang Zhang and Xu-Zhuo Fan and He Ou-Yang and Yu-Qing Liu and An-Chen Lv and Jia-Wei Zhao and Cheng-Wu Shi and Shi-Kui Han}, doi = {10.1002/anie.202414720}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414720}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molybdenum disulfide induced phase control synthesis of multi-dimensional Co3S4-MoS2 heteronanostructures via cation exchange}, volume = {64}, year = {2025}, }
• (2025). Asymmetric coupled binuclear-site catalysts for low-temperature selective acetylene semi-hydrogenation. ANGEW, 64(2), e202414719. (www)

  @article{ , abstract = {Heterogeneous metal catalysts with bifunctional active sites are widely used in chemical industries. Although their improvement process is typically based on trial-and-error, it is hindered by the lack of model catalysts. Herein, we report an effective vacancy-pair capturing strategy to fabricate 12 heterogeneous binuclear-site catalysts (HBSCs) comprising combinations of transition metals on titania. During the synthesis of these HBSCs, proton-passivation treatment and step-by-step electrostatic anchorage enabled the suppression of single-atom formation and the successive capture of two target metal cations on the titanium–oxygen vacancy-pair site. Additionally, during acetylene hydrogenation at 20 °C, the HBSCs (e.g., Pt 1 Pd 1 −TiO 2 ) consistently generated more than two times the ethylene produced by their single-atom counterparts (e.g., Pd 1 −TiO 2 ). Furthermore, the Pt 1 Pd 1 binuclear sites in Pt 1 Pd 1 −TiO 2 were demonstrated to catalyze C 2 H 2 hydrogenation via a bifunctional active-site mechanism: initially C 2 H 2 chemisorb on the Pt 1 site, then H 2 dissociates and migrates from Pd 1 to Pt 1 , and finally hydrogenation occurs at the Pt 1 −Pd 1 interface.}, archive = {J_ANGEW}, author = {Fei Lu and Jingnan Wang and Shanshan Chai and Yan Wang and Yongbin Yao and Xi Wang}, doi = {10.1002/anie.202414719}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414719}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric coupled binuclear-site catalysts for low-temperature selective acetylene semi-hydrogenation}, volume = {64}, year = {2025}, }
• (2025). Asymmetric catalytic synthesis of allylic sulfenamides from vinyl α-diazo compounds by a rearrangement route. ANGEW, 64(2), e202414712. (www)

  @article{ , abstract = {The asymmetric rearrangement of allylic sulfilimines is an effective route to synthetically attractive targets, such as allylic sulfenamides. The current methods are limited to chirality transfer from chiral allylic sulfilimine precursors. Herein, we report a general and fundamentally new rearrangement route to access optically enriched allylic sulfenamides and their derivatives. The process involves S-alkylation and an unusual S-to-N rearrangement step. A chiral nickel complex enables the transformation of a broad scope of sulfenamides and vinyl α-diazo pyrazoleamides under mild conditions. Various allylic sulfenamides have been synthesized with excellent γ-regioselectivity and enantioselectivity, and can be efficiently converted into sulfinamide and 4-aminobutenoic acid derivatives. In addition, DFT calculations demonstrate the connection between the spin state and conformation of the nickel vinyl carbenoid, as well as an unknown rearrangement process.}, archive = {J_ANGEW}, author = {Zhijie Xiao and Maoping Pu and Yuzhen Li and Wei Yang and Fei Wang and Xiaoming Feng and Xiaohua Liu}, doi = {10.1002/anie.202414712}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414712}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric catalytic synthesis of allylic sulfenamides from vinyl α-diazo compounds by a rearrangement route}, volume = {64}, year = {2025}, }
• (2025). Computational stabilization of a non-heme iron enzyme enables efficient evolution of new function. ANGEW, 64(2), e202414705. (www)

  @article{ , abstract = {Deep learning tools for enzyme design are rapidly emerging, and there is a critical need to evaluate their effectiveness in engineering workflows. Here we show that the deep learning-based tool ProteinMPNN can be used to redesign Fe(II)/αKG superfamily enzymes for greater stability, solubility, and expression while retaining both native activity and industrially relevant non-native functions. This superfamily has diverse catalytic functions and could provide a rich new source of biocatalysts for synthesis and industrial processes. Through systematic comparisons of directed evolution trajectories for a non-native, remote C( sp 3 )−H hydroxylation reaction, we demonstrate that the stabilized redesign can be evolved more efficiently than the wild-type enzyme. After three rounds of directed evolution, we obtained a 6-fold activity increase from the wild-type parent and an 80-fold increase from the stabilized variant. To generate the initial stabilized variant, we identified multiple structural and sequence constraints to preserve catalytic function. We applied these criteria to produce stabilized, catalytically active variants of a second Fe(II)/αKG enzyme, suggesting that the approach is generalizable to additional members of the Fe(II)/αKG superfamily. ProteinMPNN is user-friendly and widely accessible, and our results provide a framework for the routine implementation of deep learning-based protein stabilization tools in directed evolution workflows for novel biocatalysts.}, archive = {J_ANGEW}, author = {Brianne R. King and Kiera H. Sumida and Jessica L. Caruso and David Baker and Jesse G. Zalatan}, doi = {10.1002/anie.202414705}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414705}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Computational stabilization of a non-heme iron enzyme enables efficient evolution of new function}, volume = {64}, year = {2025}, }
• (2025). Dipole moment dictates the preferential immobilization in gel electrolytes for ah-level aqueous zinc-metal batteries. ANGEW, 64(2), e202414702. (www)

  @article{ , abstract = {Aqueous Zn-metal batteries are of great interest due to their high material abundance, low production cost, and excellent safety. However, they suffer from severe side reactions and notorious dendrite growth closely related to electrolytes. Here, in situ generated zwitterionic polymers are used as gel electrolytes to overcome these problems. It is shown that anions and H 2 O, but not anions and cations, are preferentially immobilized at different sites of zwitterionic polymers, facilitating the free migration of Zn 2+ and reducing the side reactions. This immobilization can be associated with the dipole moment of zwitterionic polymers. As a result, poly[3-dimethyl(methacryloyloxy ethyl) ammonium propane sulfonate] (PDMAPS) stands out from a series of zwitterionic polymers and outperforms the other candidates in electrochemical performance. The symmetric cells using PDMAPS smoothly operate ~9000 h at 0.5 mA cm −2 for 0.5 mAh cm −2 , much better than the controls. Moreover, PDMAPS enables an Ah-level pouch cell for continuous cycling. These results not only benefit the rational molecular design of advanced electrolytes, but also demonstrate the promising potential of zwitterionic polymers in aqueous Zn-metal batteries.}, archive = {J_ANGEW}, author = {Shaojie Zhang and Huaisheng Ao and Jingjing Dong and Dongdong Wang and Chenggang Wang and Xijin Xu and Zhiguo Hou and Jian Yang}, doi = {10.1002/anie.202414702}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414702}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dipole moment dictates the preferential immobilization in gel electrolytes for ah-level aqueous zinc-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Tailoring copper single-atoms-stabilized metastable transition-metal-dichalcogenides for sustainable hydrogen production. ANGEW, 64(2), e202414701. (www)

  @article{ , abstract = {Unconventional 1T′ phase transition metal dichalcogenides (TMDs) show great potential for hydrogen evolution reaction (HER). However, they are susceptible to transitioning into the stable 2H phase, which reduces their catalytic activity and stability. Herein, we present a scalable approach for designing thermally stable 1T′-TMDs hollow structures (HSs) by etching Cu 1.94 S templates from pre-synthesized Cu 1.94 S@TMDs heterostructures, including 1T′-MoS 2 , MoSe 2 , WS 2 , and WSe 2 HSs. Furthermore, taking 1T′-MoS 2 HSs as an example, the etched Cu ions can be firmly adsorbed on their surface in the form of single atoms (SAs) through Cu−S bonds, thereby elevating the phase transition temperature from 149 °C to 373 °C. Due to the advantages conferred by the 1T′ phase, hollow structure, and synergistic effect between Cu SAs and 1T′-MoS 2 supports, the fabricated 1T′-MoS 2 HSs demonstrate superior HER performance. Notably, their high-phase stability enables continuous operation of designed 1T′-MoS 2 HSs for up to 200 hours at an ampere-level current density without significant activity decay. This work provides a universal method for synthesizing highly stable 1T′-TMDs electrocatalysts, with a particular focus on the relationship between their phase and catalytic stability.}, archive = {J_ANGEW}, author = {Lixin Yi and Kunkun Nie and Binjie Li and Yujia Zhang and Chen Hu and Xiaorong Hao and Ziyi Wang and Xiaoyan Qu and Zhengqing Liu and Wei Huang}, doi = {10.1002/anie.202414701}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring copper single-atoms-stabilized metastable transition-metal-dichalcogenides for sustainable hydrogen production}, volume = {64}, year = {2025}, }
• (2025). Bismuthenium cations for the transport of chloride anions via pnictogen bonding. ANGEW, 64(2), e202414699. (www)

  @article{ , abstract = {Our interest in the design of heavy pnictogen-based Lewis acids for anion trafficking across biological membrane mimics has led us to investigate trivalent bismuthenium cations as chloride anion transporters. Here, we describe two chlorodiarylbismuthines, elaborated on a peri -substituted naphthalene backbone and stabilized by an adjacent thio- or seleno-ether functionality that engages the bismuth center in a Ch→Bi interaction (Ch=chalcogen). These new derivatives are stable in aqueous environment and readiliy transport chloride anions across the membrane of phospholipid-based vesicles loaded with KCl. In addition to establishing the use of such motifs in anion transport, this investigation shows that the Lewis acidity, lipophilicity, and thus chloride transport properties depend on the nature of the chalcogen.}, archive = {J_ANGEW}, author = {Nathanael H. Hunter and François P. Gabbaï}, doi = {10.1002/anie.202414699}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414699}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bismuthenium cations for the transport of chloride anions via pnictogen bonding}, volume = {64}, year = {2025}, }
• (2025). Disilicon-mediated carbon monoxide activation: From a 1,2,3-trisila- to 1,3-disilacyclopentadienes with hypercoordinate λ4Si-λ3C double bonds. ANGEW, 64(2), e202414696. (www)

  @article{ , abstract = {The facile reaction of the SiPh 2 -bridged bis-silylene (LSi:) 2 SiPh 2 (L=PhC(NBu t ) 2 ) with diphenylacetylene affords the unprecedented 1,2,3-trisilacyclopentadiene (LSi) 2 (PhC) 2 SiPh 2 1 with a hypercoordinate λ 4 Si−λ 3 Si double bond. Compound 1 is very oxophilic and consumes three molar equivalents of inert N 2 O to form the bicyclic oxygenation product 2 through O-atom insertion in the Si=Si and Si−Si bonds. Strikingly, 1 can completely split the C≡O bonds of carbon monoxide under ambient conditions (1 atm, room temperature), yielding the 1,3-disilacyclopentadiene 3 , representing the first hypercoordinate example of a cyclosilene with a λ 4 Si-λ 3 C double bond. Likewise, reaction of Xyl-NC (Xyl=2,6-dimethylphenyl), an isocyanide isoelectronic with CO, with 1 furnishes the related 1,3-disilacyclopentadiene 4 but with an amidinato silylene pendent attached to the Si=C carbon ring atom.}, archive = {J_ANGEW}, author = {Shenglai Yao and Markus Stefan Budde and Xing Yang and Yun Xiong and Lili Zhao and Matthias Driess}, doi = {10.1002/anie.202414696}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414696}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Disilicon-mediated carbon monoxide activation: From a 1,2,3-trisila- to 1,3-disilacyclopentadienes with hypercoordinate λ4Si-λ3C double bonds}, volume = {64}, year = {2025}, }
• (2025). Synergistic tuning of microstructure and morphology in carbon molecular sieve hollow fibers for Propylene/Propane separation. ANGEW, 64(2), e202414683. (www)

  @article{ , abstract = {Asymmetric carbon molecular sieve (CMS) hollow fiber membranes with tunable micro- and macro-structural morphologies for energy efficient propylene-propane separation are reported here. A sub-glass transition temperature (sub-Tg) thermal oxidative crosslinking strategy enables simultaneous optimization of the intrinsic molecular sieving properties while also reducing the thickness of the CMS “skin” derived from the 6FDA : BPDA/DAM polyimide precursors. Such synergistic tuning of CMS microstructure and macroscopic morphology of CMS hollow fibers enables significantly increased propylene permeance (reaching 186.5 GPU) while maintaining an appealing propylene/propane selectivity of 13.3 for 50/50 propylene/propane mixed gas feeds. Our findings reveal a more refined and versatile tool than available with previous O 2 -doping pretreatments. The advanced approach here should be broadly useful to other polyimide precursors and diverse gas pairs.}, archive = {J_ANGEW}, author = {Zhongyun Liu and Yuhe Cao and William J. Koros}, doi = {10.1002/anie.202414683}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414683}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic tuning of microstructure and morphology in carbon molecular sieve hollow fibers for Propylene/Propane separation}, volume = {64}, year = {2025}, }
• (2025). Flavin-catalyzed, photochemical conversion of dehydroalanine into 4,5-dihydroxynorvaline. ANGEW, 64(2), e202414679. (www)

  @article{ , abstract = {The chemical synthesis of unnatural amino acids (UAA) is a key strategy for preparing designed peptides, including pharmaceutically active compounds. Alterations of existing amino acid residues such as dehydroalanine (Dha) are particularly important since selected positions can be addressed without the necessity of a complete de novo synthesis. The intriguing UAA 4,5-dihydroxynorvaline (Dnv) is found in a variety of naturally occurring peptides and biologically active compounds. However, no method is currently available to modify an existing peptide with this residue. We report the use of flavin catalysts and visible light irradiation for this challenge, which serves as a versatile strategy for converting Dha into Dnv. Our study shows that excited flavins are competent hydrogen atom abstraction catalysts for ethers and acetals, which allows masked 1,2-dihydroxyethylene functionalization from 2,2-dimethyl-1,3-dioxolane. The masked diol was successfully coupled to Dha residues, and a series of Dnv-containing products is reported. A mild and orthogonal protocol for deprotection of the acetal group was also identified, allowing free Dnv-modified peptides to be obtained. This method provides a straightforward strategy for Dnv functionalization, which is envisioned to be crucial for accessing natural products and synthetic analogues with pharmaceutical activity.}, archive = {J_ANGEW}, author = {Tim Langschwager and Golo Storch}, doi = {10.1002/anie.202414679}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414679}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Flavin-catalyzed, photochemical conversion of dehydroalanine into 4,5-dihydroxynorvaline}, volume = {64}, year = {2025}, }
• (2025). Prolonging charge carrier lifetime via intraband defect levels in S-scheme heterojunctions for artificial photosynthesis. ANGEW, 64(2), e202414672. (www)

  @article{ , abstract = {S-scheme heterostructure photocatalysts, distinguished by unique charge-transfer pathways and exceptional catalytic redox capabilities, have found widespread applications in addressing challenging chemical processes, including the photocatalytic reduction of CO 2 with a high reaction barrier. Nevertheless, the influence of intraband defect levels within S-scheme heterojunctions on charge separation, carrier lifetime, and surface catalytic reactions has, for the most part, been overlooked. Herein, we develop a tunable defect-level-assisted strategy to construct an electron reservoir, effectively prolonging the lifetime of charge carriers through the rapid capture and gradual release of photoelectrons within WO 3-x /In 2 S 3 S-scheme heterojunctions, as authenticated by femtosecond transient absorption spectroscopy and theoretical simulations. The surface photoredox mechanism, unraveled by Gibbs free energy calculations, demonstrates that oxygen-vacancy-induced defect states in WO 3-x /In 2 S 3 heterojunctions unlock the rate-determining H 2 O oxidation into free oxygen molecules by forming metastable oxygen intermediates, contributing to the facilitation of H 2 O photooxidation. This distinct role, combined with the extended carrier lifetime, results in boosted CO 2 photoreduction with nearly 100 % CO selectivity in the absence of any photosensitizer or scavenger. Our work sheds light on the role of controllable defect levels in governing charge transfer dynamics within S-scheme heterojunctions, thereby inspiring the development of more advanced photocatalysts for artificial photosynthesis.}, archive = {J_ANGEW}, author = {Feiyan Xu and Ying He and Jianjun Zhang and Guijie Liang and Chengyuan Liu and Jiaguo Yu}, doi = {10.1002/anie.202414672}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414672}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Prolonging charge carrier lifetime via intraband defect levels in S-scheme heterojunctions for artificial photosynthesis}, volume = {64}, year = {2025}, }
• (2025). Rational construction of cyanide-functionalized D-A-π-D covalent organic framework for highly efficient overall H2O2 photosynthesis from air and water. ANGEW, 64(2), e202414658. (www)

  @article{ , abstract = {Sacrificial-agent-free overall photosynthesis of H 2 O 2 from water and air represents currently a promising route to reform the industrial anthraquinone production manner, but, still blocks by the requirement of pure O 2 feedstock, due to the insufficient oxygen supply from water under air. Herein, we report a rational molecule design on COFs (covalent organic frameworks) equiped with cyanide-functionalized D−A-π-D system for highly efficient overall H 2 O 2 production from air and water through photocatalytic oxygen reduction reactions (ORR) and water oxidation reaction (WOR). Without using any sacrificial agent, the as-synthesized D−A-π-D COF is found to enable a H 2 O 2 production rate as high as 4742 μmol h −1 g −1 from water and air and an O 2 utilization and conversion rate up to 88 %, exceeding the other D−A-π-A COF by respectively 1.9- and 1.3-fold. Such high performance is attributed to the tuned electronic structure and prolonged charge lifetime facilitated by the unique D−A-π-D structure and cyanide groups. This work highlights a fundamental molecule design on advanced photocatalytic COFs with complicated D–A system for low-cost and massive H 2 O 2 production.}, archive = {J_ANGEW}, author = {Liecheng Guo and Lele Gong and Yuting Yang and Zhecheng Huang and Xing Liu and Feng Luo}, doi = {10.1002/anie.202414658}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414658}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational construction of cyanide-functionalized D-A-π-D covalent organic framework for highly efficient overall H2O2 photosynthesis from air and water}, volume = {64}, year = {2025}, }
• (2025). When metal complexes evolve, and a minor species is the most active: The case of Bis(Phenanthroline)Copper in the catalysis of glutathione oxidation and hydroxyl radical generation. ANGEW, 64(2), e202414652. (www)

  @article{ , abstract = {Several copper-ligands, including 1,10-phenanthroline (Phen), have been investigated for anticancer purposes based on their capacity to bind excess copper (Cu) in cancer tissues and form redox active complexes able to catalyse the formation of reactive oxygen species (ROS), ultimately leading to oxidative stress and cell death. Glutathione (GSH) is a critical compound as it is highly concentrated intracellularly and can reduce and dissociate copper(II) from the ligand forming poorly redox-active copper(I)-thiolate clusters. Here we report that Cu-Phen 2 speciation evolves in physiologically relevant GSH concentrations. Experimental and computational experiments suggest that at pH 7.4 mostly copper(I)-GSH clusters are formed, but a minor species of copper(I) bound to one Phen and forming ternary complexes with GSH (GS−Cu-Phen) is the redox active species, oxidizing quite efficiently GSH to GSSG and forming HO⋅ radicals. This minor active species becomes more populated at lower pH, such as typical lysosomal pH 5, resulting in faster GSH oxidation and HO⋅ production. Consistently, cell culture studies showed lower toxicity of Cu-Phen 2 upon inhibition of lysosomal acidification. Overall, this study underscores that sub-cellular localisation can considerably influence the speciation of Cu-based drugs and that minor species can be the most redox- and biologically-active.}, archive = {J_ANGEW}, author = {Enrico Falcone and Vincenzo Vigna and Hemma Schueffl and Francesco Stellato and Bertrand Vileno and Merwan Bouraguba and Gloria Mazzone and Olivier Proux and Silvia Morante and Petra Heffeter and Emilia Sicilia and Peter Faller}, doi = {10.1002/anie.202414652}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414652}, shortjournal = {Angew. Chem. Int. Edit.}, title = {When metal complexes evolve, and a minor species is the most active: The case of Bis(Phenanthroline)Copper in the catalysis of glutathione oxidation and hydroxyl radical generation}, volume = {64}, year = {2025}, }
• (2025). Spiral-concave prussian blue crystals with rich steps: Growth mechanism and coordination regulation. ANGEW, 64(2), e202414650. (www)

  @article{ , abstract = {Investigating the formation and transformation mechanisms of spiral-concave crystals holds significant potential for advancing innovative material design and comprehension. We examined the kinetics-controlled nucleation and growth mechanisms of Prussian Blue crystals with spiral concave structures, and constructed a detailed crystal growth phase diagram. The spiral-concave hexacyanoferrate (SC-HCF) crystals, characterized by high-density surface steps and a low stress-strain architecture, exhibit enhanced activity due to their facile interaction with reactants. Notably, the coordination environment of SC-HCF can be precisely modulated by the introduction of diverse metals. Utilizing X-ray absorption fine structure spectroscopy and in situ ultraviolet-visible spectroscopy, we elucidated the formation mechanism of SC-HCF to Co-HCF facilitated by oriented adsorption-ion exchange (OA-IE) process. Both experimental data, and density functional theory confirm that Co-HCF possesses an optimized energy band structure, capable of adjusting the local electronic environment and enhancing the performance of the oxygen evolution reaction. This work not only elucidates the formation mechanism and coordination regulation for rich steps HCF, but also offers a novel perspective for constructing nanocrystals with intricate spiral-concave structures.}, archive = {J_ANGEW}, author = {Guangxun Zhang and Yong Li and Guangyu Du and Jingqi Lu and Qiujing Wang and Ke Wu and Songtao Zhang and Han-Yi Chen and Yizhou Zhang and Huai-Guo Xue and Mohsen Shakouri and Zheng Liu and Huan Pang}, doi = {10.1002/anie.202414650}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414650}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spiral-concave prussian blue crystals with rich steps: Growth mechanism and coordination regulation}, volume = {64}, year = {2025}, }
• (2025). Pioneering built-in interfacial electric field for enhanced anion exchange membrane water electrolysis. ANGEW, 64(2), e202414647. (www)

  @article{ , abstract = {As a half-reaction in anion exchange membrane water electrolysis (AEMWE) technology, the hydrogen evolution reaction (HER) at the cathode is severely hindered by the sluggish reaction kinetics involved in additional water dissociation step, which results in large overpotentials and low energy conversion efficiency. Here, we develop a nano-heterostructure composed of ultra-thin W 5 N 4 shells over Ni 3 N nanoparticles (Ni 3 N@W 5 N 4 ) as efficient catalysts, in which built-in interfacial electric field (BIEF) is created owing to the distinct lattice arrangements and work functions of biphasic metal nitrides. The BIEF facilitates the electron localization around the interface and enables high valence W and more exposed binding sites in the surface W 5 N 4 shell for accelerating the water dissociation step, ultimately leading to a remarkable reduction in the energy barriers of RDS from 1.40 eV to 0.26 eV. Theoretical calculations and operando X-ray absorption spectroscopy analysis results demonstrated that surface W 5 N 4 serves as the active species for HER. Moreover, the ultra-thin shell characteristics enable the optimized W 5 N 4 with enhanced intrinsic catalytic activity to be fully exposed as active sites. Consequently, the Ni 3 N@W 5 N 4 exhibits exceptional performance in alkaline HER (60 mV@10 mA cm −2 ) and remarkable long-term stability (500 mA cm −2 for 100 hours). When employed as the cathode in the AEMWE device, the synthesized Ni 3 N@W 5 N 4 demonstrates stable performance for 90 hours at a current density of 1 A cm −2 .}, archive = {J_ANGEW}, author = {Huawei Huang and Liangliang Xu and Shouwei Zuo and Yuanfu Ren and Lu Song and Chen Zou and Xingkun Wang and Javier Ruiz Martínez and Kuo-Wei Huang and Huabin Zhang}, doi = {10.1002/anie.202414647}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414647}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pioneering built-in interfacial electric field for enhanced anion exchange membrane water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Electrolyte engineering to construct robust interphase with high ionic conductivity for wide temperature range lithium metal batteries. ANGEW, 64(2), e202414636. (www)

  @article{ , abstract = {Unstable interphase formed in conventional carbonate-based electrolytes significantly hinders the widespread application of lithium metal batteries (LMBs) with high-capacity nickel-rich layered oxides (e.g., LiNi 0.8 Co 0.1 Mn 0.1 O 2 , NCM811) over a wide temperature range. To balance ion transport kinetics and interfacial stability over wide temperature range, herein a bifunctional electrolyte (EAFP) tailoring the electrode/electrolyte interphase with 1,3-propanesultone as an additive was developed. The resulting cathode-electrolyte interphase with an inorganic inner layer and an organic outer layer possesses high mechanical stability and flexibility, alleviating stress accumulation and maintaining the structural integrity of the NCM811 cathode. Meanwhile, the inorganic-rich solid electrolyte interphase inhibits electrolyte side reactions and facilitates fast Li + transport. As a result, the Li||Li cells exhibit stable performance in extensive temperatures with low overpotentials, especially achieving a long lifespan of 1000 h at 30 °C. Furthermore, the optimized EAFP is also suitable for LiFePO 4 and LiCO 2 cathodes (1000 cycles, retention: 67 %). The Li||NCM811 and graphite||NCM811 pouch cells with lean electrolyte (g/Ah grade) operate stably, verifying the broad electrode compatibility of EAFP. Notably, the Li||NCM811 cells can operate in wide climate range from −40 °C to 60 °C. This work establishes new guidelines for the regulation of interphase by electrolytes in all-weather LMBs.}, archive = {J_ANGEW}, author = {Yanan Li and Bo Wen and Na Li and Yuanjun Zhao and Yuzhi Chen and Xiangkai Yin and Xinyu Da and Yuxin Ouyang and Xinyang Li and Pengxiang Kong and Shujiang Ding and Kai Xi and Guoxin Gao}, doi = {10.1002/anie.202414636}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414636}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte engineering to construct robust interphase with high ionic conductivity for wide temperature range lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Simultaneous structural and electronic engineering on bi- and rh-co-doped SrTiO3 for promoting photocatalytic water splitting. ANGEW, 64(2), e202414628. (www)

  @article{ , abstract = {Activating metal ion-doped oxides as visible-light-responsive photocatalysts requires intricate structural and electronic engineering, a task with inherent challenges. In this study, we employed a solid (template)-molten (dopants) reaction to synthesize Bi- and Rh-codoped SrTiO 3 (SrTiO 3 : Bi,Rh) particles. Our investigation reveals that SrTiO 3 : Bi,Rh manifests as single-crystalline particles in a core (undoped)/shell (doped) structure. Furthermore, it exhibits a well-stabilized Rh 3+ energy state for visible-light response without introducing undesirable trapping states. This precisely engineered structure and electronic configuration promoted the generation of high-concentration and long-lived free electrons, as well as facilitated their transfer to cocatalysts for H 2 evolution. Impressively, SrTiO 3 : Bi,Rh achieved an exceptional apparent quantum yield (AQY) of 18.9 % at 420 nm, setting a new benchmark among Rh-doped-based SrTiO 3 materials. Furthermore, when integrated into an all-solid-state Z-Scheme system with Mo-doped BiVO 4 and reduced graphene oxide, SrTiO 3 : Bi,Rh enabled water splitting with an AQY of 7.1 % at 420 nm. This work underscores the significance of simultaneous structural and electronic engineering and introduces the solid-molten reaction as a viable approach for this purpose.}, archive = {J_ANGEW}, author = {Zhenhua Pan and Junie Jhon M. Vequizo and Hiroaki Yoshida and Jianuo Li and Xiaoshan Zheng and Chiheng Chu and Qian Wang and Mengdie Cai and Song Sun and Kenji Katayama and Akira Yamakata and Kazunari Domen}, doi = {10.1002/anie.202414628}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414628}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous structural and electronic engineering on bi- and rh-co-doped SrTiO3 for promoting photocatalytic water splitting}, volume = {64}, year = {2025}, }
• (2025). D-band-center-engineered platinum-based nanozyme for personalized pharmacovigilance. ANGEW, 64(2), e202414625. (www)

  @article{ , abstract = {A high-efficiency PtZnCd nanozyme was screened with density functional theory (DFT) and unique d-orbital coupling features for sensitive enrichment and real-time analysis of CO-releasing molecule-3 (CORM-3). Multicatalytic sites in the nanozyme showed a high reactivity of up to 72.89 min −1 for peroxidase (POD)-like reaction, which was 2.2, 4.07, and 14.67 times higher than that of PtZn (32.67 min −1 ), PtCd (17.89 min −1 ), and Pt (4.97 min −1 ), respectively. Normalization of the catalytic sites showed that the catalytic capacity of the active site in PtZnCd was 2.962 U μmol −1 , which was four times higher than that of a pure Pt site (0.733 U μmol −1 ). DFT calculations showed that improved d-orbital coupling between different metals reduces the position of the center of the shifted whole d-band relative to the Fermi energy level, thereby increasing the contribution of the sites to the electron transfer from the active center, accompanied by enhanced substrate adsorption and intermediate conversion in the catalytic process. The potential adsorption principle and color development mechanism of CORM-3 on PtZnCd were determined, and its practical application in drug metabolism was validated in vitro and in zebrafish and mice models, demonstrating that transition-metal doping effectively engineers high-performance nanozymes and optimizes artificial enzymes.}, archive = {J_ANGEW}, author = {Zhichao Yu and Zhenjin Xu and Ruijin Zeng and Man Xu and Haisu Zheng and Da Huang and Zuquan Weng and Dianping Tang}, doi = {10.1002/anie.202414625}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414625}, shortjournal = {Angew. Chem. Int. Edit.}, title = {D-band-center-engineered platinum-based nanozyme for personalized pharmacovigilance}, volume = {64}, year = {2025}, }
• (2025). [4+1] heteroannulation to form 1-pyrrolines through alder-ene reaction of in situ generated ynimines: Development and application in total synthesis of borrecapine. ANGEW, 64(2), e202414612. (www)

  @article{ , abstract = {We report in this paper a novel Cu-catalyzed synthesis of polysubstituted 1-pyrrolines. The reaction of β,γ-unsaturated oxime esters 4 with terminal alkynes 5 in the presence of a catalytic amount of Cu(OAc) 2 and 2,2′-biquinoline affords the corresponding 1,6-enynimines, which undergo a highly stereoselective Alder-ene reaction to afford 1-pyrrolines with concomitant generation of a quaternary carbon and a 2-azadiene motif. It represents an unusual [4+1] heteroannulation reaction wherein terminal alkynes act as a one carbon donor and are 1,1-difunctionalized. Mechanistic studies suggest that the allylic hydrogen trans to the oxime ester main chain is selectively transferred to the electron-rich alkyne during the pericyclic reaction. The resulting 1-pyrrolines undergo facile acid-catalyzed regioselective Wagner–Meerwein rearrangement to provide 2 H -pyrroles in excellent yields. The 2 H -pyrroles are also accessible from 4 and 5 in a one-pot manner without isolation of the 1-pyrrolines. Leveraging this heteroannulation reaction as a key step, the first total synthesis of borrecapine, a 2,3,3,5-tetrasubstituted pyrrolidine, is accomplished.}, archive = {J_ANGEW}, author = {Rémi Lavernhe and Qian Wang and Jieping Zhu}, doi = {10.1002/anie.202414612}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414612}, shortjournal = {Angew. Chem. Int. Edit.}, title = {[4+1] heteroannulation to form 1-pyrrolines through alder-ene reaction of in situ generated ynimines: Development and application in total synthesis of borrecapine}, volume = {64}, year = {2025}, }
• (2025). Self-assembled nanohelixes driven by host-guest interactions and metal coordination. ANGEW, 64(2), e202414611. (www)

  @article{ , abstract = {Helical nanostructures fabricated via the self-assembly of artificial motifs have been a captivating subject because of their structural aesthetics and multiple functionalities. Herein, we report the facile construction of a self-assembled nanohelix ( NH ) by leveraging an achiral aggregation-induced emission (AIE) luminogen ( G ) and pillar[5]arene ( H ), driven by host–guest interactions and metal coordination. Inspired by the “sergeants and soldiers” effect and “majority rule” principle, the host–guest complexation between G and H is employed to fixate the twisted conformation of G for the generation of “contortion sites”, which further induced the emergence of helicity as the 1D assemblies are formed via Ag(I) coordination and hexagonally packed into nano-sized fibers. The strategy has proved feasible in both homogeneous and heterogeneous syntheses. Along with the formation of NH , boosted luminescence and enhanced productivity of reactive oxygen species (ROS) are afforded because of the efficient restriction on G , indicating the concurrent regulation of NH ′s morphology and photophysical properties by supramolecular assembly. In addition, NH also exhibits the capacity for bacteria imaging and photodynamic antibacterial activities against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ).}, archive = {J_ANGEW}, author = {Xin-Yue Lou and Kun Zhang and Yujie Bai and Siyuan Zhang and Yuanyuan Li and Ying-Wei Yang}, doi = {10.1002/anie.202414611}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414611}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-assembled nanohelixes driven by host-guest interactions and metal coordination}, volume = {64}, year = {2025}, }
• (2025). Directional ring translocation in a pH- and redox-driven tristable [2]Rotaxane. ANGEW, 64(2), e202414609. (www)

  @article{ , abstract = {We describe the synthesis and characterization of a [2]rotaxane comprising a dibenzo-24-crown-8 (DB24C8) macrocyclic component and a thread containing three recognition sites: ammonium (AmH + ), bipyridinium (Bpy 2+ ) and triazolium (Trz + ). AmH + and Bpy 2+ are responsive to fully orthogonal stimuli, pH and electrochemical, which allows to precisely control the directional translation of the macrocycle along the axle. A better understanding of the processes driving the operation of the system was obtained thanks to an in-depth thermodynamic characterization. Orthogonal stimuli responsive tristable rotaxanes represent the starting point for the creation of linear motors and the development of molecular logic gates.}, archive = {J_ANGEW}, author = {Leonardo Andreoni and Jessica Groppi and Özlem Seven and Massimo Baroncini and Alberto Credi and Serena Silvi}, doi = {10.1002/anie.202414609}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414609}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Directional ring translocation in a pH- and redox-driven tristable [2]Rotaxane}, volume = {64}, year = {2025}, }
• (2025). Upconversion luminescence with bis-pyclen Yb(III) chelates: Crown vs. linear polyether linkers in discrete heteropolynuclear architectures. ANGEW, 64(2), e202414608. (www)

  @article{ , abstract = {Ligands combining two lateral bis-pyridyl-phosphonated-pyclens were synthesized, using a flexible linear pegylated linker ( L2 ) or a bulkier K22 crown-ether ( L3 ). A functionalized pyridyl-phosphonated-pyclen ( L1 ) was also prepared as a mononuclear analogue. Coordination behavior of lanthanide cations was studied via NMR titration with Lu for L1 , and UV/Vis and luminescence spectroscopy with Yb for L2 / L3 . Strong coordination of two Yb atoms enabled isolation and spectroscopic characterization of dinuclear complexes in H 2 O and D 2 O. Excited state lifetime analysis at 980 nm revealed strong protection of Yb cations, with no coordinated water molecule. Upon titration of the isolated dinuclear Yb complexes with Tb cations, cooperative upconversion (UC) sensitization of Tb in the visible was observed upon excitation of Yb at 980 nm in D 2 O. In the absence of Tb, the Yb complexes also exhibited cooperative luminescence with a weak emission band around 500 nm upon NIR Yb excitation. Efficient UC with Tb was only observed after thermal treatment, suggesting a slow kinetic of formation of the UC species. [Yb 2 Tb L3 ] showed weak Tb centered UC emission, while the dinuclear complex of L2 displayed more intense UC emission up to two equivalents of Tb, forming [(Yb 2 L2 )Tb x ] ( x =1–2), with the tetranuclear heterometallic complex being the most intense emitter. Log-Log plot analysis confirmed the two-photon nature of the UC process.}, archive = {J_ANGEW}, author = {Nadège Hamon and Léna Godec and Samuel Sanchez and Maryline Beyler and Loïc J. Charbonnière and Raphaël Tripier}, doi = {10.1002/anie.202414608}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414608}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Upconversion luminescence with bis-pyclen Yb(III) chelates: Crown vs. linear polyether linkers in discrete heteropolynuclear architectures}, volume = {64}, year = {2025}, }
• (2025). Ultra-tough dynamic supramolecular ion-conducting elastomer induced uniform li+ transport and stabilizes interphase ensures dendrite-free lithium metal anodes. ANGEW, 64(2), e202414599. (www)

  @article{ , abstract = {Artificial polymer solid electrolyte interphases (SEIs) with microphase-separated structures provide promising solutions to the inhomogeneity and cracking issues of natural SEIs in lithium metal batteries (LMBs). However, achieving homogeneous ionic conductivity, excellent mechanical properties, and superior interfacial stability remains challenging due to interference from hard-phase domains in ion transport and solid-solid interface issues with lithium metal. Herein, we present a dynamic supramolecular ion-conducting poly (urethane-urea) interphase (DSIPI) that achieves these three properties through modulating the hard-phase domains and constructing a composite SEI in situ. The soft-phase polytetrahydrofuran backbone, featuring loose Li + −O coordinating interactions, ensures uniform Li + transport. Concurrently, sextuple hydrogen bonds in the hard phase dissipate strain energy through sequential bond cleavage, thereby imparting exceptional mechanical properties. Moreover, enriched bis (trifluoromethanesulfonyl) imide anion (TFSI − ) in DSIPI promotes the in situ formation of a stable polymer-inorganic composite SEI during cycling. Consequently, the DSIPI-protected lithium anode (DSIPI@Li) enables symmetric cells with exceptional cyclability exceeding 4,000 hours at an ultra-high current density of 20 mA cm −2 , thereby demonstrating excellent cycling stability. Furthermore, DSIPI@Li facilitates stable operation of the pouch cells under the constraints of a high-loading LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode and low negative/positive capacity (N/P) ratio. This work presents a powerful strategy for designing artificial SEIs and high-performance LMBs.}, archive = {J_ANGEW}, author = {Hong Liu and Fengxu Zhen and Xiangkai Yin and Yingbin Wu and Kailiang Yu and Xiangpeng Kong and Shujiang Ding and Wei Yu}, doi = {10.1002/anie.202414599}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414599}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultra-tough dynamic supramolecular ion-conducting elastomer induced uniform li+ transport and stabilizes interphase ensures dendrite-free lithium metal anodes}, volume = {64}, year = {2025}, }
• (2025). Doping in vivo alkylation in e. coli by introducing the direct sulfurylation pathway of s. cerevisiae. ANGEW, 64(2), e202414598. (www)

  @article{ , abstract = {Methylation and alkylation are important techniques used for the synthesis and derivatisation of small molecules and natural products. Application of S-adenosylmethionine (SAM)-dependent methyltransferases (MTs) in biotechnological hosts such as Escherichia coli lowers the environmental impact of alkylation compared to chemical synthesis and facilitates regio- and chemoselective alkyl chain transfer. Here, we address the limiting factor for SAM synthesis, methionine supply, to accelerate in vivo methylation activity. Introduction of the direct sulfurylation pathway, consisting of O-acetylhomoserine sulfhydrolase (ScOAHS) and O-acetyltransferase (ScMET2), from S. cerevisiae into E. coli and supplementation with methanethiol or the corresponding disulfide improves atom-economic methylation activity in three different MT reactions. Up to 17-fold increase of conversion compared to the sole expression of the MT and incorporation of up to 79 % of the thiol compound added were achieved. Promiscuity of ScOAHS allowed in vivo production of methionine analogues from organic thiols. Further co-overproduction of a methionine adenosyltransferase yielded SAM analogues which were further transferred by MTs onto different substrates. For methylation of non-physiological substrates, conversion rates up to 73 % were achieved, with an isolated yield of 41 % for N-methyl-2,5-aminonitrophenol. The here described technique enables E. coli to become a biotechnological host for improved methylation and selective alkylation reactions.}, archive = {J_ANGEW}, author = {Michael K. F. Mohr and Patricia Benčić and Jennifer N. Andexer}, doi = {10.1002/anie.202414598}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414598}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Doping in vivo alkylation in e. coli by introducing the direct sulfurylation pathway of s. cerevisiae}, volume = {64}, year = {2025}, }
• (2025). Moiré lattice of twisted bilayer graphene as template for non-covalent functionalization. ANGEW, 64(2), e202414593. (www)

  @article{ , abstract = {We present a novel approach to achieve spatial variations in the degree of non-covalent functionalization of twisted bilayer graphene (tBLG). The tBLG with twist angles varying between ~5° and 7° was non-covalently functionalized with 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HATCN) molecules. Our results show a correlation between the degree of functionalization and the twist angle of tBLG. This correlation was determined through Raman spectroscopy, where areas with larger twist angles exhibited a lower HATCN peak intensity compared to areas with smaller twist angles. We suggest that the HATCN adsorption follows the moiré pattern of tBLG by avoiding AA-stacked areas and attach predominantly to areas with a local AB-stacking order of tBLG, forming an overall ABA-stacking configuration. This is supported by density functional theory (DFT) calculations. Our work highlights the role of the moiré lattice in controlling the non-covalent functionalization of tBLG. Our approach can be generalized for designing nanoscale patterns on two-dimensional (2D) materials using moiré structures as a template. This could facilitate the fabrication of nanoscale devices with locally controlled varying chemical functionality.}, archive = {J_ANGEW}, author = {Tobias Dierke and Stefan Wolff and Roland Gillen and Jasmin Eisenkolb and Tamara Nagel and Sabine Maier and Milan Kivala and Frank Hauke and Andreas Hirsch and Janina Maultzsch}, doi = {10.1002/anie.202414593}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Moiré lattice of twisted bilayer graphene as template for non-covalent functionalization}, volume = {64}, year = {2025}, }
• (2025). Coronene-based 2D networks by on-surface skeletal rearrangement of sumanene precursors. ANGEW, 64(2), e202414583. (www)

  @article{ , abstract = {The design of novel low-dimensional carbon materials is at the forefront of modern chemistry. Recently, on-surface covalent synthesis has emerged as a powerful strategy to synthesize previously precluded compounds and polymers. Here, we report a scanning probe microscopy study, complemented by theoretical calculations, on the sequential skeletal rearrangement of sumanene-based precursors into a coronene-based organometallic network by stepwise intra- and inter-molecular reactions on Au(111). Interestingly, upon higher annealing, the formed organometallic networks evolve into two-dimensional coronene-based covalently linked patches through intermolecular homocoupling reactions. A new reaction mechanism is proposed based on the role of C−Au−C motifs to promote two stepwise carbon-carbon couplings to form cyclobutadiene bridges. Our results pave avenues for the conversion of molecular precursors on surfaces, affording the design of unexplored two-dimensional organometallic and covalent materials.}, archive = {J_ANGEW}, author = {Elena Pérez-Elvira and Ana Barragán and Aurelio Gallardo and José Santos and Cristina Martín-Fuentes and Koen Lauwaet and José M. Gallego and Rodolfo Miranda and Hidehiro Sakurai and José I. Urgel and Jonas Björk and Nazario Martín and David Écija}, doi = {10.1002/anie.202414583}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414583}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coronene-based 2D networks by on-surface skeletal rearrangement of sumanene precursors}, volume = {64}, year = {2025}, }
• (2025). Propane dehydrogenation on PtxZny active sites in silicalite-1. ANGEW, 64(2), e202414578. (www)

  @article{ , abstract = {The improvement of Pt-based catalysts for propane dehydrogenation (PDH) has progressed by recent investigations that have identified Zn as a promising promoter for Pt subnanometer catalysts. It is desirable to gain insights into the structure, stability, and activity of such active sites and the factors that influence them, such as Zn : Pt ratio, Pt coordination and nuclearity. Here, we employ density functional theory and microkinetic simulations to investigate the stability of Pt x Zn y ( x =1–3, y=0–3) active sites grafted on silanols of Silicalite-1 and the PDH activity of Pt. We find that the coordination of a Pt atom to a nest of grafted Zn(II) atoms increases the stability of the Pt 1 Zn y sites, whose activity is similar for y=0–2 and drops dramatically for y>2. We further demonstrate, via linear scaling relations and microkinetic simulations, that the turnover frequency obeys a volcano law as a function of propylene binding strength. The Pt 2 Zn 1 and Pt 3 Zn 1 sites are stable and exhibit activity similar to Pt 1 Zn 2 , but only Pt 1 Zn 2 manifests reaction kinetics consistent with experimental data, strongly suggesting the active site composition in the synthesized catalyst samples. The methodology presented here suggests a general strategy for deducing active site information such as composition through simple kinetic experiments.}, archive = {J_ANGEW}, author = {Yilang Liu and Antara Bhowmick and Dongxia Liu and Stavros Caratzoulas and Dionisios G. Vlachos}, doi = {10.1002/anie.202414578}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414578}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Propane dehydrogenation on PtxZny active sites in silicalite-1}, volume = {64}, year = {2025}, }
• (2025). Carbon nanocage supported asymmetrically coordinated nickle single-atom for enhanced CO2 electroreduction in membrane electrode assembly. ANGEW, 64(2), e202414569. (www)

  @article{ , abstract = {Designing efficient catalysts for operating CO 2 electroreduction in membrane electrode assembly (MEA) faces significant obstacles. Herein, we propose an asymmetrically coordinated Ni single-atom catalyst featuring axial Br coordination at NiN 4 Br sites anchoring onto hollow Br/N co-doped carbon nanocages, achieved through a NaBr-assisted confined-pyrolysis strategy. The Ni-NBr-C catalyst exhibits a high CO Faradaic efficiency (FE CO >97 %) over the current density range of 50 to 350 mA cm −2 in the MEA device. Furthermore, Ni-NBr-C shows a stable cell voltage of 2.66±0.2 V while delivering a large current density of 350 mA cm −2 over an 85-hour long-term operation, demonstrating its potential for industrial-scale applications. Advanced characterization techniques and theoretical calculations reveal that the coordination and doping of Br not only enhance the intrinsic activity but also highlight that the unique pore structure improves mass transfer efficiency.}, archive = {J_ANGEW}, author = {Yingxi Lin and Chenfeng Xia and Zhaozhao Zhu and Junjie Wang and Huiting Niu and Shuning Gong and Zhao Li and Na Yang and Jun Song Chen and Rui Wu and Bao Yu Xia}, doi = {10.1002/anie.202414569}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414569}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Carbon nanocage supported asymmetrically coordinated nickle single-atom for enhanced CO2 electroreduction in membrane electrode assembly}, volume = {64}, year = {2025}, }
• (2025). Triazine-based large-sized single-crystalline two-dimensional covalent organic framework for high-performance lithium-ion batteries. ANGEW, 64(2), e202414566. (www)

  @article{ , abstract = {A large-sized single crystalline 2D COFs with excellent crystallinity and stability was prepared through the traditional thermal solvent method. The electrochemical performance can be significantly enhanced using a straightforward hybrid approach that involves in situ growth of the 2D COFs on multi-walled carbon nanotubes (MWCNTs). Both the advantages of COFs and CNTs are mutually enhanced. The single-crystalline feature of the obtained COFs improves the structural integrity and brings excellent chemical and electrochemical stabilities for lithium-ion battery applications. The resultant COF-CNT core–shell hybrids greatly improved the conductivity and demonstrated excellent lithium-ion storage performance with a high capacity of 228 mAh g −1 (0.2 A g −1 ).}, archive = {J_ANGEW}, author = {Jiaheng Hou and Hui Liu and Meng Gao and Qingyan Pan and Yingjie Zhao}, doi = {10.1002/anie.202414566}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414566}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Triazine-based large-sized single-crystalline two-dimensional covalent organic framework for high-performance lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Thin zinc electrodes stabilized with organobromine-partnered H2O−Zn−MeOH cluster ions for practical zinc-metal pouch cells. ANGEW, 64(2), e202414562. (www)

  @article{ , abstract = {The utilization of thin zinc (Zn) anodes with a high depth of discharge is an effective strategy to increase the energy density of aqueous Zn metal batteries (ZMBs), but challenged by the poor reversibility of Zn electrode due to the serious Zn-consuming side reactions at the Zn||electrolyte interface. Here, we introduce 2-bromomethyl-1,3-dioxolane (BDOL) and methanol (MeOH) as electrolyte additive into aqueous ZnSO 4 electrolyte. In the as-formulated electrolyte, BDOL with a strong electron-withdrawing group (−CH 2 Br) tends to pair with the H 2 O−Zn−MeOH complex, leading to the formation of organobromine-partnered H 2 O−Zn−MeOH cluster ions. During the Zn electrodeposition process, the formed ZnO-dominated by-products induce the polymerization of BDOL monomers, which are previously adsorbed on the electrode. As a result, a uniform dual-layer SEI with ZnO-dominated outer layer and polyether-dominated inner layer is built on the surface of Zn electrode. With such an in situ formed dual-layer SEI, the Zn||Mg 0.9 Mn 3 O 7 ⋅ 2.7H 2 O pouch cell using a 10-um Zn anode (corresponding to a low negative to positive areal capacity ratio of 3.56) successfully operated for 300 cycles with a high capacity retention of 86 %, promising a high practical energy density of >120 Wh/kg (based on the total mass of Zn and Mg 0.9 Mn 3 O 7 ⋅ 2.7H 2 O).}, archive = {J_ANGEW}, author = {Jie Ji and Haoran Du and Zhenglu Zhu and Xiaoqun Qi and Fei Zhou and Rui Li and Ruining Jiang and Long Qie and Yunhui Huang}, doi = {10.1002/anie.202414562}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414562}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thin zinc electrodes stabilized with organobromine-partnered H2O−Zn−MeOH cluster ions for practical zinc-metal pouch cells}, volume = {64}, year = {2025}, }
• (2025). The P(III)-amidite based synthesis of stable isotope labeled mRNA-cap-structures enables their sensitive quantitation from brain tissue. ANGEW, 64(2), e202414537. (www)

  @article{ , abstract = {The 5’ cap structure is crucial to mRNA function, with its diverse methylation patterns depending on the cellular state. Sensitive analytical methods are sought after to quantify this cap variety also referred to as cap epitranscriptome. To address a bottleneck for accurate and precise quantitation, we report a facile and fast access to high-quality synthetic standards via a new route, involving P(III)-amidite chemistry. A range of cap nucleotides and their stable heavy isotopic labeled analogues were derived from nucleoside diphosphates, which themselves were directly prepared in a one-step reaction sequence starting from unprotected nucleosides using a triphosphorylating reagent in combination with ethylenediamine. Considering a wider scope, the route also enables direct access to magic spot nucleotides and diphosphates of isoprenyl-alcohols. Stable-isotope labeled cap nucleotides derived from this route paved the way for the development of a highly sensitive LC–MS/MS method, applied to the characterization of mouse brain cap epitranscriptomes, which turned out to be very different from those of cultured cell lines of widespread use in the life sciences.}, archive = {J_ANGEW}, author = {Alexander Ripp and Martina Krämer and Vanessa Barth and Patrick Moser and Thomas M. Haas and Jyoti Singh and Tamara Huck and Lukas Gleue and Kristina Friedland and Mark Helm and Henning J. Jessen}, doi = {10.1002/anie.202414537}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414537}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The P(III)-amidite based synthesis of stable isotope labeled mRNA-cap-structures enables their sensitive quantitation from brain tissue}, volume = {64}, year = {2025}, }
• (2025). Organic room temperature phosphorescence from BN-substituted xanthene derivatives. ANGEW, 64(2), e202414534. (www)

  @article{ , abstract = {Emissive organic materials are predominantly fluorescent and there is significant interest in realizing and understanding examples that defy this paradigm and exhibit phosphorescence under ambient conditions. Organic room temperature phosphorescence (ORTP) offers the long-lived excited states and bathochromically-shifted emission maxima of phosphorescence without the use of potentially toxic and expensive transition metals. Most ORTP materials rely on well-studied structural motifs that include aryl carbonyls, sulfones, and heavy main group elements. We report the unexpected ORTP of a series of heavy atom-free BN-substituted xanthene derivatives. The creation of heteroatom-rich scaffolds, combined with stabilizing C−H⋅⋅⋅F interactions in the solid-state, resulted in oxygen-tolerant heavy atom-free organic phosphorescence without relying on the use of cryogenic temperatures, polymer matrices, or host–guest interactions. The observation of ORTP in these simple systems sets a blueprint for the further development of heavy atom-free organic phosphors.}, archive = {J_ANGEW}, author = {Alexander E. R. Watson and Si Yuan Tao and Alex Siemiarczuk and Paul D. Boyle and Paul J. Ragogna and Joe B. Gilroy}, doi = {10.1002/anie.202414534}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414534}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organic room temperature phosphorescence from BN-substituted xanthene derivatives}, volume = {64}, year = {2025}, }
• (2025). Oxindolyl-based radicals with tunable mechanochromic and thermochromic behavior. ANGEW, 64(2), e202414533. (www)

  @article{ , abstract = {Organic radicals based dynamic covalent chemistry is promising in preparing stimuli-responsive chromic materials, due to their simplicity of dissociation/association, accompanied with distinct color changes during the process. However, suitable organic radicals for dynamic covalent chemistry have not been widely explored yet. Herein, a series of oxindolyl-based mono-radicals (OxRs) with different substituents were successfully synthesized and studied systematically as potential building blocks for stimuli-responsive chromic materials. These OxRs would dimerize spontaneously to form their corresponding dimers. The structures of dimers were unambiguously confirmed through low-temperature 1 H NMR and single-crystal X-ray diffraction analyses. Dynamic interconversion between monomers and dimers was achieved by reversible cleavage and recovery of the σ-bond upon soft external stimuli (temperature, pressure, and solvent polarity), accompanied by significant color changes. It is interesting that the stability of the mono-radical could be tuned through changing different substituents, and consequently altering the bond dissociation energy of the dynamic covalent bond between monomers. These new OxRs characterized by appreciable properties are entitled to more opportunities in developing mechanochromic and thermochromic materials, where their responsiveness to stimuli can be readily controlled by the substituents adhered.}, archive = {J_ANGEW}, author = {Tingting Xu and Yi Han and Yong Ni and Chunyan Chi}, doi = {10.1002/anie.202414533}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414533}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxindolyl-based radicals with tunable mechanochromic and thermochromic behavior}, volume = {64}, year = {2025}, }
• (2025). The regulation of solid electrolyte interphase on composite lithium anodes in solid-state batteries. ANGEW, 64(2), e202414524. (www)

  @article{ , abstract = {Solid-state lithium metal batteries (SSLMBs) with solid polymer electrolyte (SPE) are highly promising for next-generation energy storage due to their enhanced safety and energy density. However, the stability of the solid electrolyte interphase (SEI) on the lithium metal/SPE interface is a major challenge, as continuous SEI degradation and regeneration during cycling lead to capacity fading. This article investigates the SEI formation on lithium anodes (l-SEI) and composite lithium anodes (c-SEI) in solid-state lithium metal batteries. The composite anodes form a uniform Li 2 S-rich inorganic SEI layer and a thinner organic SEI layer, effectively passivating the interface for enhanced cycling stability. Specifically, the full cells with c-SEI anodes sustain over 400 cycles at 0.5 C under a high areal capacity of 2.0 mAh cm −2 . Moreover, the reversible high-loading solid-state pouch cells exhibit exceptional safety even after curling and cutting. These findings offer valuable insights into developing composite electrodes with robust SEI for solid-state polymer-based lithium metal batteries.}, archive = {J_ANGEW}, author = {Zi-You Wang and Chen-Zi Zhao and Nan Yao and Yang Lu and Zhou-Qing Xue and Xue-Yan Huang and Pan Xu and Wen-Ze Huang and Zi-Xuan Wang and Jia-Qi Huang and Qiang Zhang}, doi = {10.1002/anie.202414524}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414524}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The regulation of solid electrolyte interphase on composite lithium anodes in solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). Customizing bonding affinity with multi-intermediates via interfacial electron capture to boost hydrogen evolution in alkaline water electrolysis. ANGEW, 64(2), e202414518. (www)

  @article{ , abstract = {Developing efficient and earth-abundant alkaline HER electrocatalysts is pivotal for sustainable energy, but co-regulating its intricate multi-step process, encompassing water dissociation, OH − desorption, and hydrogen generation, is still a great challenge. Herein, we tackle these obstacles by fabricating a vertically integrated electrode featuring a nanosheet array with prominent dual-nitride metallic heterostructures characterized by impeccable lattice matching and excellent conductivity, functioning as a multi-purpose catalyst to fine-tune the bonding affinity with alkaline HER intermediates. Detailed structural characterization and theoretical calculation elucidate that charge redistribution at the heterointerface reduces the O p -W d and H s -W d interactions vs. single nitride, thereby enhancing OH − transfer and H 2 release. As anticipated, the resulting WN-NiN/CFP catalyst demonstrates a gratifying low overpotential of 36.8 mV at 10 mA/cm 2 for alkaline HER, while concurrently maintaining operational stability for 1300 h at 100 mA/cm 2 for overall water splitting. This work presents an effective approach to meticulously optimize multiple site-intermediate interactions in alkaline HER, laying the foundation for efficient energy conversion.}, archive = {J_ANGEW}, author = {Liu Yang and Huibing Liu and Ying Li and Lisong Zhong and Zhaohui Jin and Xiaopei Xu and Dapeng Cao and Zhongwei Chen}, doi = {10.1002/anie.202414518}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414518}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Customizing bonding affinity with multi-intermediates via interfacial electron capture to boost hydrogen evolution in alkaline water electrolysis}, volume = {64}, year = {2025}, }
• (2025). Strong metal-support interaction triggered by molten salts. ANGEW, 64(2), e202414516. (www)

  @article{ , abstract = {Strong metal-support interaction (SMSI) plays a vital role in tuning the geometric and electronic structures of metal species. Generally, a high-temperature treatment (>500 °C) in reducing atmosphere is required for constructing SMSI, which may induce the sintering of metal species. Herein, we use molten salts as the reaction media to trigger the formation of high-intensity SMSI at reduced temperatures. The strong ionic polarization of the molten salt promotes the breakage of Ti−O bonds in the TiO 2 support, and hence decreases the energy barrier for the formation of interfacial bonds. Consequently, a high-intensity SMSI state is achieved in TiO 2 supported Ir nanoclusters, evidenced by a large number of Ir−Ti bonds at the interface, at a low temperature of 350 °C. Moreover, this method is applicable for triggering SMSI in various supported metal catalysts with different oxide supports including CeO 2 and SnO 2 . This newly developed SMSI construction methodology opens a new avenue and holds significant potential for engineering advanced supported metal catalysts toward a broad range of applications.}, archive = {J_ANGEW}, author = {Wei Guo and Guoqiang Zhao and Zixiang Huang and Zhouxin Luo and Xusheng Zheng and Mingxia Gao and Yongfeng Liu and Hongge Pan and Wenping Sun}, doi = {10.1002/anie.202414516}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414516}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strong metal-support interaction triggered by molten salts}, volume = {64}, year = {2025}, }
• (2025). Transient transition from stable to dissipative assemblies in response to the spatiotemporal availability of a chemical fuel. ANGEW, 64(2), e202414495. (www)

  @article{ , abstract = {The transition from inactive to active matter implies a transition from thermodynamically stable to energy-dissipating structures. Here, we show how the spatiotemporal availability of a chemical fuel causes a thermodynamically stable self-assembled structure to transiently pass to an energy-dissipating state. The system relies on the local injection of a weak affinity phosphodiester substrate into an agarose hydrogel containing surfactant-based structures templated by ATP. Injection of substrate leads to the inclusion of additional surfactant molecules in the assemblies leading to the formation of catalytic hotspots for substrate conversion. After the local disappearance of the substrate as a result of chemical conversion and diffusion the assemblies spontaneously return to the stable state, which can be reactivated upon the injection of a new batch of fuel. The study illustrates how a dissipating self-assembled system can cope with the intermittent availability of chemical energy without compromising long-term structural stability.}, archive = {J_ANGEW}, author = {Haridas Kar and Rui Chen and Krishnendu Das and Leonard J. Prins}, doi = {10.1002/anie.202414495}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414495}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transient transition from stable to dissipative assemblies in response to the spatiotemporal availability of a chemical fuel}, volume = {64}, year = {2025}, }
• (2025). High mass transfer rate in electrocatalytic hydrogen evolution achieved with efficient quasi-gas phase system. ANGEW, 64(2), e202414493. (www)

  @article{ , abstract = {The adhesion of H 2 bubbles on the electrode surface is one of the main factors limiting the performance of H 2 evolution of electrolytic water, especially at high current density. To overcome this problem, here a “quasi-gas phase” electrolytic water reaction system based on capillary effect is proposed for the first time to improve the mass transfer efficiency of H 2 . The typical feature of this reaction system is that the main site of H 2 evolution reaction is transferred from the bulk aqueous solution to the gas phase environment above the bulk aqueous solution, thus effectively inhibiting the aggregation of H 2 bubbles and reducing the resistance of their diffusion away. Electrochemical test results show that the proposed quasi-gas phase system can significantly reduce the potential required in H 2 evolution reaction process at high current density compared with the conventional electrolytic reaction system. Specifically, the overpotential potential is reduced by 0.31 V when the H 2 evolution current density of 250 mA cm −2 is achieved.}, archive = {J_ANGEW}, author = {Dan Xie and Liang-Xin Ding and Sibo Chen and Gao-Feng Chen and Hui Cheng and Haihui Wang}, doi = {10.1002/anie.202414493}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414493}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High mass transfer rate in electrocatalytic hydrogen evolution achieved with efficient quasi-gas phase system}, volume = {64}, year = {2025}, }
• (2025). Control of dynamic chirality in donor-acceptor fluorophores. ANGEW, 64(2), e202414490. (www)

  @article{ , abstract = {Recently, the control of dynamic chirality has emerged as a powerful strategy to design chiral functional materials. In this context, we describe herein a molecular design in which a tethered configurationally stable binaphthyl chiral unit efficiently controls the dynamic chirality of donor-acceptor fluorophores, involving diverse indolocarbazoles as electron donors and terephthalonitrile as an electron acceptor. The high conformational discrimination in such a molecular system suggested by density functional theory calculations is experimentally probed using electronic and vibrational circular dichroism and confirmed by the crystallization of these chiral molecules in gel and their single crystal X-ray diffraction analysis. This work also highlights the positive effect of the configurationally stable chiral unit on the magnitude of the dissymmetry factors of the active dynamically chiral fluorophores, both in ground and excited states, through chiral perturbation.}, archive = {J_ANGEW}, author = {Max Coehlo and Lucas Frédéric and Laurélie Poulard and Nawal Ferdi and Lilian Estaque and Alaric Desmarchelier and Gilles Clavier and Jean-Pierre Dognon and Ludovic Favereau and Michel Giorgi and Jean-Valère Naubron and Gregory Pieters}, doi = {10.1002/anie.202414490}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414490}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Control of dynamic chirality in donor-acceptor fluorophores}, volume = {64}, year = {2025}, }
• (2025). The fischer-lactonization-driven mechanism for ultra-efficient recycling of spent lithium-ion batteries. ANGEW, 64(2), e202414484. (www)

  @article{ , abstract = {Hydrometallurgy remains a major challenge to simplify its complex separation and precipitation processes for spent lithium-ion batteries (LIBs). Herein, we propose a Fischer-lactonization-driven mechanism for the cascade reaction of leaching and chelation of spent LIBs. Citric acid undergoes a two-step dissociation of the carboxylic acid (−COOH) and complexes with the leached metal ion, while the residual −COOH is attacked by H protons to form a protonated carboxyl ion (−COO −). Subsequently, the lone pair of electrons in the hydroxyl of the same molecule attack the carbon atom in −COO − to facilitate ester bonding, leading to the formation of a lactonized gel. The leaching rates of Li, Ni, Co and Mn are 99.3, 99.1, 99.5 and 99.2 %, respectively. The regenerated monocrystalline LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM523) has a uniform particle size distribution and complete lamellar structure, with a capacity retention rate of 70.6 % after 250 cycles at 0.5 C. The mechanism achieves a one-step chelation reaction, and the energy consumption and carbon emissions are only 26 % and 44 %, respectively, of that of the conventional hydrometallurgical. The strategy achieves a double breakthrough in simplifying the process and improving environmental friendliness, offering a sustainable approach to the re-utilization of spent LIBs.}, archive = {J_ANGEW}, author = {Miaomiao Zhou and Ji Shen and Yinze Zuo and Ruiping Liu and Jianjun Zhao and Guangmin Zhou}, doi = {10.1002/anie.202414484}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414484}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The fischer-lactonization-driven mechanism for ultra-efficient recycling of spent lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Oxygen reduction reaction coupled electro-oxidation for highly-efficient and sustainable water treatment. ANGEW, 64(2), e202414481. (www)

  @article{ , abstract = {Electro-oxidation (EO) technology demonstrates significant potential in wastewater treatment. However, the high energy consumption has become a pivotal constraint hindering its large-scale implementation. Herein, we design an EO and 4-electron oxygen reduction reaction coupled system (EO-4eORR) to replace the traditional EO and hydrogen evolution reaction (HER) coupled system (EO-HER). The theoretical cathodic potential of the electrolytic reactor is tuned from 0 V (vs. RHE) in HER to 1.23 V (vs. RHE) in 4eORR, which greatly decreases the required operation voltage of the reactor. Moreover, we demonstrate that convection can improve the mass transfer of oxygen and organic pollutants in the reaction system, leading to low cathodic polarization and high pollutant removal rate. Compared with traditional EO-HER system, the energy consumption of the EO-4eORR system under air aeration for 95 % total organic carbon (TOC) removal is greatly decreased to 2.61 kWh/kgTOC (only consider the electrolyzer energy consumption), which is superior to previously reported EO-based water treatment systems. The reported results in this study offer a new technical mode for development of highly efficient and sustainable EO-based treatment systems to remove organic pollutants in waste water.}, archive = {J_ANGEW}, author = {Xiaomeng Ran and Hehe Qin and Xiangyun Liu and Chengcheng Chu and Qiuju Li and Hongying Zhao and Shun Mao}, doi = {10.1002/anie.202414481}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414481}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oxygen reduction reaction coupled electro-oxidation for highly-efficient and sustainable water treatment}, volume = {64}, year = {2025}, }
• (2025). A critical view on the use of DNA hydrogels in cell-free protein synthesis. ANGEW, 64(2), e202414480. (www)

  @article{ , abstract = {Numerous studies have reported in the past that the use of protein-encoding DNA hydrogels as templates for cell-free protein synthesis (CFPS) leads to better yields than the use of conventional templates such as plasmids or PCR fragments. Systematic investigation of different types of bulk materials from pure DNA hydrogels and DNA hydrogel composites using a commercially available CFPS kit showed no evidence of improved expression efficiency. However, protein-coding DNA hydrogels were advantageously used in microfluidic reactors as immobilized templates for repetitive protein production, suggesting that DNA-based materials offer potential for future developments in high-throughput profiling or rapid in situ characterization of proteins.}, archive = {J_ANGEW}, author = {Svenja Moench and Phillip Lemke and Abbey Hansen and Christoph Bickmann and Martin Peng and Kersten S. Rabe and Carmen M. Domínguez and Christof M. Niemeyer}, doi = {10.1002/anie.202414480}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414480}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A critical view on the use of DNA hydrogels in cell-free protein synthesis}, volume = {64}, year = {2025}, }
• (2025). Dual ion co-insertion induced spontaneous and reversible phase conversion chemistry for unprecedented zn2+ storage. ANGEW, 64(2), e202414479. (www)

  @article{ , abstract = {Prussian blue analogues are highly promising electrode materials due to their versatile electrochemical activity and low cost. However, they often suffer from severe structural damage caused by the Jahn–Teller distortion and dissolution of high-spin outer metal ions, resulting in poor cycle life. Material modification and electrolyte regulation have been the common approaches to address this issue, albeit with very limited success. We report here a novel and efficient strategy to preserve structural stability by co-inserting Co 2+ and Zn 2+ ions in KCo[Fe(CN) 6 ]. This co-insertion induced a spontaneous and reversible phase conversion by the replacement of low-spin inner ion (Fe 3+ ), which efficiently relieves structural damage caused by Jahn–Teller distortion and metal-ion dissolution, leading to an outstanding Zn 2+ storage capacity and an exceptional improvement of cycle life with a capacity retention of 97.7 % over 4400 cycles at 40 C. We also demonstrated the enhancement of co-intercalation on ion migration using a combined approach of experimental and density functional theory (DFT) calculations. This work provides an important progress to solve the cycle stability of Prussian blue analogues towards their practical application as electrode materials for aqueous batteries.}, archive = {J_ANGEW}, author = {Xikun Zhang and Junwei Zhang and Haoxiang Yu and Thomas L. Madanu and Maoting Xia and Pengcheng Xing and Alexandru Vlad and Jie Shu and Bao-Lian Su}, doi = {10.1002/anie.202414479}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414479}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual ion co-insertion induced spontaneous and reversible phase conversion chemistry for unprecedented zn2+ storage}, volume = {64}, year = {2025}, }
• (2025). Emulating “Curvature-enhanced adsorbate coverage” for superconformal and orientated zn electrodeposition in zinc-ion-batteries. ANGEW, 64(2), e202414473. (www)

  @article{ , abstract = {Uneven Zn deposition and unfavorable side reactions have prevented the reversibility of the Zn anode. Herein, we design a rearranged (002) textured Zn anode inspired by a traditional curvature-enhanced adsorbate coverage (CEAC) process to realize the highly reversible Zn anode. The rearranged (002) textured structure directs superconformal Zn deposition by controlling the spatial deposition rate of the rearranged crystal planes, thereby promoting bottom-up “superfilling” of the 3D Zn skeletons. Meanwhile, our designed anode also induces the epitaxial Zn deposition, alleviating the parasitic reactions owing to the lowest surface energy of the (002) plane. Attributed to these superiorities, uniform and oriented Zn deposition can be obtained, exhibiting an ultra-long lifespan over 479 hrs at an ultrahigh depth of discharge (DOD) of 82.12 %. The Zn|Na 2 V 6 O 16 ⋅ 3H 2 O battery delivers an improved cycling performance, even at a high area capacity of 5.15 mAh/cm 2 with a low negative/positive (N/P) capacity ratio of 1.63. The superconformal deposition approach for Zn anodes paves the way for the practical application of high-performance zinc-ion batteries.}, archive = {J_ANGEW}, author = {Huibo Wang and Yi Liu and Mengyu Zhu and Yuejin Chen and Danling Chen and Zhimin Lin and Kexuan Wang and Zhu Xu and Shi Chen and Guichuan Xing and Oleksandr I. Malyi and Yuxin Tang and Yanyan Zhang}, doi = {10.1002/anie.202414473}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414473}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Emulating “Curvature-enhanced adsorbate coverage” for superconformal and orientated zn electrodeposition in zinc-ion-batteries}, volume = {64}, year = {2025}, }
• (2025). Interfacially fabricated covalent organic framework membranes for film-based fluorescence humidity sensors and moisture driven actuators. ANGEW, 64(2), e202414472. (www)

  @article{ , abstract = {Rapid, on-site measurement of ppm-level humidity in real time remains a challenge. In this work, we fabricated a few micrometer thick, β -ketoenamine-linked covalent organic framework (COF) membrane via interfacially confined condensation of 1,3,5-tris-(4-aminophenyl)triazine (TTA) with 1,3,5-tri-formylphloroglucinol (TP). Based on the super-sensitive and reversible response of the COF membrane to water vapor, we developed a high-performance film-based fluorescence humidity sensor, depicting unprecedented detection limit of 0.005 ppm, fast response/recovery (2.2 s/2.0 s), and a detection range from 0.005 to 100 ppm. Remarkably, more than 7,000-time continuous tests showed no observable change in the performance of the sensor. The applicability of the sensor was verified by on-site and real-time monitoring of humidity in a glovebox. The superior performance of the sensor was ascribed to the highly porous structure and unique affinity of the COF membrane to water molecules as they enable fast mass transfer and efficient utilization of the water binding sites. Moreover, based on the remarkable moisture driven deformation of the COF membrane and its composition with the known polyimide films, some conceptual actuators were created. This study brings new ideas to the design of ultra-sensitive film-based fluorescent sensors (FFSs) and high-performance actuators.}, archive = {J_ANGEW}, author = {Xiangquan Liu and Rongrong Huang and Lingya Peng and Jinglun Yang and Junbao Yan and Binbin Zhai and Yan Luo and Chi Zhang and Shuwen Tan and Xiaoyan Liu and Liping Ding and Yu Fang}, doi = {10.1002/anie.202414472}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414472}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Interfacially fabricated covalent organic framework membranes for film-based fluorescence humidity sensors and moisture driven actuators}, volume = {64}, year = {2025}, }
• (2025). Boryloxy titanium complex-enabled high polar monomer contents in catalytic copolymerization of olefins. ANGEW, 64(2), e202414464. (www)

  @article{ , abstract = {The preparation of polyolefins with high polar monomer contents (above 20 mol %) has long been a challenge. Half-titanocenes (Cp′)[HCN(Ar)] 2 BOTiCl 2 bearing bulky electron-donating N-heterocyclic boryloxy ligands have been designed and synthesized. The complexes (Cp*)[HCN(Ar)] 2 BOTiCl 2 (2, Ar=2,6- i Pr 2 C 6 H 3 ; 5, Ar=2,4,6-Me 3 C 6 H 2 ) supported by Cp* and the boryloxy ligands have been shown to efficiently catalyze the copolymerization of ethylene and long chain α-olefins. In particular, precatalyst 5 enabled the controlled synthesis of poly(ethylene- co -9-decen-1-ol) with unprecedented high polar monomer contents up to 32.1 mol % while maintaining the high catalytic activity. The structural analysis and DFT calculations disclosed that the bulky and strong electron-donating boryloxy ligands could effectively stabilize cationic active species. The mechanical studies on the hydroxyl-functionalized copolymers disclosed that they exhibited high strength and toughness because of the existence of hydrogen bonds in the polymer network.}, archive = {J_ANGEW}, author = {Chuanzhi Wei and Lulu Guo and Cheng Zhu and Chunming Cui}, doi = {10.1002/anie.202414464}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414464}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boryloxy titanium complex-enabled high polar monomer contents in catalytic copolymerization of olefins}, volume = {64}, year = {2025}, }
• (2025). Hydrogen-bonded complexes of HPN⋅ and HNP⋅ radicals with carbon monoxide. ANGEW, 64(2), e202414456. (www)

  @article{ , abstract = {Phosphorus mononitride (PN) is a carrier of phosphorus in the interstellar medium. As the simplest derivatives of PN, the radical species HPN⋅ and HNP⋅ have remained elusive. Herein, we report the generation, characterization, and photochemistry of HPN⋅ and HNP⋅ in N 2 -matrix at 3 K. Specifically, HPN⋅ was formed as a weakly bonded complex with CO in the matrix by 254 nm photolysis of the novel phosphinyl radical HPNCO⋅. The ⋅NPH−CO complex is extremely unstable, as it undergoes spontaneous isomerization to the lower-energy isomer ⋅PNH−CO through fast quantum mechanical tunneling (QMT) with a half-life of 6.1 min at 3 K. Upon further irradiation at 254 nm, the reverse conversion of ⋅PNH−CO to ⋅NPH−CO along with dehydrogenation to yield PN was observed. The characterization ⋅NPH−CO and ⋅PNH−CO with matrix-isolation IR spectroscopy is supported by D, 15 N, and 13 C isotope labeling and quantum chemical calculations at the XYGJ-OS/AVTZ level of theory, and the mechanism by hydrogen atom tunneling is consistent with multidimensional instanton theory calculations.}, archive = {J_ANGEW}, author = {Junjie Jiang and Longtian Huang and Bifeng Zhu and Wenbin Fan and Lina Wang and Igor Ying Zhang and Wei Fang and Tarek Trabelsi and Joseph S. Francisco and Xiaoqing Zeng}, doi = {10.1002/anie.202414456}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414456}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hydrogen-bonded complexes of HPN⋅ and HNP⋅ radicals with carbon monoxide}, volume = {64}, year = {2025}, }
• (2025). Highly active photoreduction of atmospheric-concentration CO2 into CH3COOH over palladium particles on Nb2O5 nanosheets. ANGEW, 64(2), e202414453. (www)

  @article{ , abstract = {The endeavor to drive CO 2 photoreduction towards the synthesis of C 2 products is largely thwarted by the colossal energy hurdle inherent in C−C coupling. Herein, we load active metal particles on metal oxide nanosheets to build the dual metal pair sites for steering C−C coupling to form C 2 products. Taking Pd particles anchored on the Nb 2 O 5 nanosheets as an example, the high-angle annular dark-field image and X-ray photoelectron spectroscopy demonstrate the presence of Pd−Nb metal pair sites on the Pd-Nb 2 O 5 nanosheets. Density functional theory calculations reveal these sites exhibit a low reaction energy barrier of only 1.02 eV for C−C coupling, implying that the introduction of Pd particles effectively tailors the reaction step to form C 2 products. Therefore, the Pd-Nb 2 O 5 nanosheets achieve a CH 3 COOH evolution rate of 13.5 μmol g −1 h −1 in photoreduction of atmospheric-concentration CO 2 , outshining all other single photocatalysts reported to date under analogous conditions.}, archive = {J_ANGEW}, author = {Jinyu Ding and Peijin Du and Peipei Li and Wenxiu Liu and Jiaqi Xu and Wensheng Yan and Yang Pan and Jun Hu and Junfa Zhu and Qingxia Chen and Xingchen Jiao and Yi Xie}, doi = {10.1002/anie.202414453}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414453}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly active photoreduction of atmospheric-concentration CO2 into CH3COOH over palladium particles on Nb2O5 nanosheets}, volume = {64}, year = {2025}, }
• (2025). High-stable all-iron redox flow battery with innovative anolyte based on steric hindrance regulation. ANGEW, 64(2), e202414452. (www)

  @article{ , abstract = {All-soluble all-iron redox flow batteries (AIRFBs) are an innovative energy storage technology that offer significant financial benefits. Stable and affordable redox-active materials are essential for the commercialization of AIRFBs, yet the battery stability must be significantly improved to achieve practical value. Herein, ferrous complexes combined with the triisopropanolamine (TIPA) ligand are identified as promising anolytes to extend battery life by reducing cross-contamination due to a pronounced steric hindrance effect. The coordination structure and failure mechanism of our Fe-TIPA complexes were determined by molecular dynamics simulation and spectroscopic experiments. By coupling with [Fe(CN) 6 ] 4−/3− , Fe-TIPA/Fe-CN AIRFBs retained excellent stability exceeding 1831 cycles at 80 mA ⋅ cm −2 , yielding an energy efficiency of ~80 % and maintaining a steady discharge capacity. Moreover, the all-soluble electrolyte was tested in an industrial-scale Fe-TIPA/Fe-CN AIRFB prototype energy storage system, where an energy efficiency of 81.3 % was attained. Given the abundance of iron resources, we model the TIPA AIRFB electrolyte cost to be as low as 32.37 $/kWh, which is significantly cheaper than the current commercial level. This work demonstrates that steric hindrance is an effective measure to extended battery life, facilitating the commercial development of affordable flow batteries.}, archive = {J_ANGEW}, author = {Jiahui Yang and Wei Wei and Chengxi Zhou and Hui Yan and Hangxin Che and Leiduan Hao and Xinyi Tan and Alex W. Robertson and Tai-Sing Wu and Yun-Liang Soo and Ao Tang and Zhenyu Sun}, doi = {10.1002/anie.202414452}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414452}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-stable all-iron redox flow battery with innovative anolyte based on steric hindrance regulation}, volume = {64}, year = {2025}, }
• (2025). Singlet oxygen photocatalytic generation by silanized TiO2 nanoparticles. ANGEW, 64(2), e202414445. (www)

  @article{ , abstract = {A commercial TiO 2 sample, used as received or hydrothermally treated to increase surface hydroxylation, has been functionalized by surface modification with hexadecyltrimethoxysilane. The anchoring of the silane has been characterized by means of FTIR and solid-state NMR spectroscopies, and the grafting density was determined by thermogravimetric and N 2 physisorption analyses. The silane moieties induce a partial decrease of the shielding of the valence electrons of the Ti ions at the surface, and a local modification of their crystal field, as demonstrated by XPS and UV/Vis spectroscopy, respectively. The changes in coordination and the produced oxygen vacancies result in the formation of Ti 3+ defects localized in the sub-surface region, as revealed by EPR spectroscopy. These paramagnetic centers are stabilized in the silanized samples, as the electron transfer to O 2 is efficiently inhibited even under UV irradiation. However, the amount of Ti 3+ centers appears to be correlated with the singlet oxygen ( 1 O 2 ) formation rate. Accordingly, epoxidation of limonene under UV light, chosen as a model photocatalytic reaction triggered by 1 O 2 , occurred with higher selectivity when TiO 2 was silanized and upon simultaneous NIR irradiation. These evidences suggest that in the silanized sample 1 O 2 may be generated through Förster-type energy transfer from excited sub-surface Ti 3+ centers.}, archive = {J_ANGEW}, author = {Francesco Parrino and Alessandro Gottuso and Lorenzo Viganò and Pietro Mariani and Irene Villa and Francesca Cova and Emanuela Callone and Sandra Dirè and Leonardo Palmisano and Matus Stredansky and Massimiliano D'Arienzo}, doi = {10.1002/anie.202414445}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414445}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Singlet oxygen photocatalytic generation by silanized TiO2 nanoparticles}, volume = {64}, year = {2025}, }
• (2025). Catalyzing PET-RAFT polymerizations using inherently photoactive zinc myoglobin. ANGEW, 64(2), e202414431. (www)

  @article{ , abstract = {Protein photocatalysts provide a modular platform to access new reaction pathways and affect product outcomes, but their use in polymer synthesis is limited because co-catalysts and/or co-reductants are required to complete catalytic cycles. Herein, we report using zinc myoglobin (ZnMb), an inherently photoactive protein, to mediate photoinduced electron/energy transfer (PET) reversible addition-fragmentation chain transfer (RAFT) polymerizations. Using ZnMb as the sole reagent for catalysis, photomediated polymerizations of N , N -dimethylacrylamide in PBS were achieved with predictable molecular weights, dispersity values approaching 1.1, and high chain-end fidelity. We found that initial apparent rate constants of polymerization increased from 4.6×10–5 s −1 for zinc mesoporpyhrin IX (ZnMIX) to 6.5×10–5 s −1 when ZnMIX was incorporated into myoglobin to yield ZnMb, indicating that the protein binding site enhanced catalytic activity. Chain extension reactions comparing ZnMb-mediated RAFT polymerizations to thermally-initiated RAFT polymerizations showed minimal differences in block copolymer molecular weights and dispersities. This work enables studies to elucidate how protein modifications (e.g., secondary structure folding, site-directed mutagenesis, directed evolution) can be used to modulate polymerization outcomes (e.g., selective monomer additions towards sequence control, tacticity control, molar mass distributions).}, archive = {J_ANGEW}, author = {Ian C. Anderson and Darwin C. Gomez and Meijing Zhang and Stephen J. Koehler and C. Adrian Figg}, doi = {10.1002/anie.202414431}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414431}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalyzing PET-RAFT polymerizations using inherently photoactive zinc myoglobin}, volume = {64}, year = {2025}, }
• (2025). Establishing non-stoichiometric Ti4O7 assisted asymmetrical C−C coupling for highly energy-efficient electroreduction of carbon monoxide. ANGEW, 64(2), e202414416. (www)

  @article{ , abstract = {Exploring an appropriate support material for Cu-based electrocatalyst is conducive for stably producing multi-carbon chemicals from electroreduction of carbon monoxide. However, the insufficient metal-support adaptability and low conductivity of the support would hinder the C−C coupling capacity and energy efficiency. Herein, non-stoichiometric Ti 4 O 7 was incorporated into Cu electrocatalysts (Cu−Ti 4 O 7 ), and served as a highly conductive and stable support for highly energy-efficient electrochemical conversion of CO. The abundant oxygen vacancies originated from ordered lattice defects in Ti 4 O 7 facilitate the water dissociation and the CO adsorption to accelerate the hydrogenation to *COH. The highly adaptable metal-support interface of Cu−Ti 4 O 7 enables a direct asymmetrical C−C coupling between *CO on Cu and *COH on Ti 4 O 7 , which significantly lowers the reaction energy barrier for C 2+ products formation. Additionally, the excellent electroconductivity of Ti 4 O 7 benefits the reaction charge transfer through robust Cu/Ti 4 O 7 interface for minimizing the energy loss. Thus, the optimized 20Cu−Ti 4 O 7 catalyst exhibits an impressive selectivity of 96.4 % and ultrahigh energy efficiency of 45.1 % for multi-carbon products, along with a remarkable partial current density of 432.6 mA cm −2 . Our study underscores a novel C−C coupling strategy between Cu and the support material, advancing the development of Cu-supported catalysts for highly efficient electroreduction of carbon monoxide.}, archive = {J_ANGEW}, author = {Xuli Hu and Junchen Xu and Yunchen Gao and Zhenyao Li and Jun Shen and Wei Wei and Yangshun Hu and Yushan Wu and Yao Wang and Mingyue Ding}, doi = {10.1002/anie.202414416}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Establishing non-stoichiometric Ti4O7 assisted asymmetrical C−C coupling for highly energy-efficient electroreduction of carbon monoxide}, volume = {64}, year = {2025}, }
• (2025). Dinuclear cyclometalated pincer Nickel(II) complexes with metal-metal-to-ligand charge transfer excited states and near-infrared emission. ANGEW, 64(2), e202414411. (www)

  @article{ , abstract = {Facile non-radiative decay of low-lying metal-centered (MC) dd excited states has been well documented to pose a significant obstacle to the development of phosphorescent Ni II complexes due to substantial structural distortions between the dd excited state and the ground state. Herein, we prepared a series of dinuclear Ni 2 II,II complexes by using strong σ-donating carbene-phenyl-carbene (C NHC C phenyl C NHC ) pincer ligands, and prepared their dinuclear Pt 2 II,II and Pd 2 II,II analogues. Dinuclear Ni 2 II,II complexes bridged by formamidinate/α-carbolinato ligand exhibit short Ni−Ni distances of 2.947–3.054 Å and singlet metal-metal-to-ligand charge transfer ( 1 MMLCT) transitions at 500–550 nm. Their 1 MMLCT absorption energies are red-shifted relative to the Pt 2 II,II and Pd 2 II,II analogues at ~450 nm and ≤420 nm respectively. One-electron oxidation of these Ni 2 II,II complexes produces valence-trapped dinuclear Ni 2 II,III species, which are characterized by EPR spectroscopy. Upon photoexcitation, these Ni 2 II,II complexes display phosphorescence (τ=2.6–8.6 μs) in the NIR (800–1400 nm) spectral region in 2-MeTHF and in the solid state at 77 K, which is insensitive to π-conjugation of the coordinated [C NHC C phenyl C NHC ] ligand. Combined with DFT calculations, the NIR emission is assigned to originate from the 3 dd excited state. Studies have found that the dinuclear Ni 2 II,II complex can sensitize the formation of singlet oxygen and catalyze the oxidation of cyclo-dienes under light irradiation.}, archive = {J_ANGEW}, author = {Mengyue Gao and Wai-Pong To and Glenna So Ming Tong and Lili Du and Kam-Hung Low and Zhou Tang and Wei Lu and Chi-Ming Che}, doi = {10.1002/anie.202414411}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414411}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dinuclear cyclometalated pincer Nickel(II) complexes with metal-metal-to-ligand charge transfer excited states and near-infrared emission}, volume = {64}, year = {2025}, }
• (2025). Synthesis and structural characterization of carbazole-tailored luminescent triarylmethyl radical and its stable cation. ANGEW, 64(2), e202414406. (www)

  @article{ , abstract = {The development of novel luminescent radicals, characterized by their unique doublet emission, endows a significant challenge. In this study, we reported the synthesis of a luminescent neutral radical, BCzAnM-R, tailored by two carbazolyl groups and an anthryl group to achieve a nonalternant structure. It exhibited near-infrared emission with a peak at 1020 nm in toluene. Interestingly, its corresponding cation, BCzAnM-C, was synthesized through an unconventional SnCl 2 -mediated reduction-aromatization-oxidation reaction in one-pot and gram-scale. The cation demonstrated remarkable stability for up to weeks in ambient conditions and facilitated the silica-gel chromatography isolation as an organic salt with SnCl 3 − as the counter ion. The carbazolyl groups effectively modulate molecular structures, photophysical properties, and stabilities. Notably, BCzAnM-R represents the first luminescent triarylmethyl radical with two carbazolyl groups directly attached to the central carbon.}, archive = {J_ANGEW}, author = {Chunlin Tang and Yuxin Zhu and Jian Jin and Shuai Zhang and Kang Zhou and Zikai He}, doi = {10.1002/anie.202414406}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414406}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and structural characterization of carbazole-tailored luminescent triarylmethyl radical and its stable cation}, volume = {64}, year = {2025}, }
• (2025). Living cell-mediated catalyst-free spontaneous polymerization of zwitterionic methacrylates for preparation of probiotic-loaded hydrogels. ANGEW, 64(2), e202414400. (www)

  @article{ , abstract = {Living cell-mediated polymerization offers promising applications in biomaterials, yet its further biological utilization is hindered by the need for metal ions or radical initiators with available methods. In this study, we introduce a living cell-mediated polymerization that leverages the intrinsic metabolic activities of living cells to initiate and sustain free radical polymerization of zwitterionic methacrylates. The polymerization proceeded in the absence of transition metal catalysts, radical initiators, or light sources. The conversion of zwitterionic methacrylate strongly correlated with cellular activities and achieved a maximum conversion of 98 % within 48 hours. Living cells efflux redox power across membranes through metabolism and that terminal electron fluxes are captured by zwitterionic methacrylates pre-assembled on the living cell surface to initiate radical polymerization reactions. The polymerization caused significant changes to the cell membrane surface and synthesized hydrogels with tailored mechanical properties. The polymer hydrogel obtained via probiotic E. coli Nissle 1917 was able to release the in situ encapsulated molecules, which demonstrated living cell-mediated polymer hydrogel as a vehicle for the delivery of both cellular and molecular therapeutic agents. This research offered a green and efficient method for synthesizing bioactive materials and advancing the field of cellular therapeutics and drug delivery.}, archive = {J_ANGEW}, author = {Yuke Li and Yiming Huang and Zhiqiang Gao and Gang Song and Fengting Lv and Haotian Bai and Shu Wang}, doi = {10.1002/anie.202414400}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414400}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Living cell-mediated catalyst-free spontaneous polymerization of zwitterionic methacrylates for preparation of probiotic-loaded hydrogels}, volume = {64}, year = {2025}, }
• (2025). Tailoring O-monodentate adsorption of CO2 initiates C−N coupling for efficient urea electrosynthesis with ultrahigh carbon atom economy. ANGEW, 64(2), e202414392. (www)

  @article{ , abstract = {The thermodynamically and kinetically sluggish electrocatalytic C−N coupling from CO 2 and NO 3 − is inert to initially take place while typically occurring after CO 2 protonation, which severely dwindles urea efficiency and carbon atom economy. Herein, we report a single O-philic adsorption strategy to facilitate initial C−N coupling of *OCO and subsequent protonation over dual-metal hetero-single-atoms in N 2 −Fe−(N−B) 2 −Cu−N 2 coordination mode (FeN 4 /B 2 CuN 2 @NC), which greatly inhibits the formation of C-containing byproducts and facilitates urea electrosynthesis in an unprecedented C-selectivity of 97.1 % with urea yield of 2072.5 μg h −1 mg cat. −1 and 71.9 % Faradaic efficiency, outperforming state-of-the-art electrodes. The carbon-directed antibonding interaction with Cu−B is elaborated to benefit single O-philic adsorption of CO 2 rather than conventional C-end or bridging O,O-end adsorption modes, which can accelerate the kinetics of initiated C−N coupling and protonation. Theoretical results indicate that the O-monodentate adsorption pathway benefits the thermodynamics of the C−N coupling of *OCO with *NO 2 and the protonation rate-determining step, which markedly inhibits CO 2 direct protonation. This oriented strategy of manipulating reactant adsorption patterns to initiate a specific step is universal to moderate oxophilic transition metals and offers a kinetic-enhanced path for multiple conversion processes.}, archive = {J_ANGEW}, author = {Min Zhou and Yan Zhang and Hu Li and Zhengyi Li and Su Wang and Xihong Lu and Song Yang}, doi = {10.1002/anie.202414392}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414392}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring O-monodentate adsorption of CO2 initiates C−N coupling for efficient urea electrosynthesis with ultrahigh carbon atom economy}, volume = {64}, year = {2025}, }
• (2025). Does h2 temperature-programmed reduction always probe solid-state redox chemistry? the case of Pt/CeO2. ANGEW, 64(2), e202414388. (www)

  @article{ , abstract = {Redox reactions on the surface of transition metal oxides are of broad interest in thermo, photo, and electrocatalysis. H 2 temperature-programmed reduction (H 2 -TPR) is commonly used to probe oxide reducibility by measuring the rate of H 2 consumption during temperature ramps, assuming that this rate is controlled by oxide reduction. However, oxide reduction involves several elementary steps, such as H 2 dissociation and H-spillover, before surface reduction and H 2 O formation occur. In this study, we evaluated the kinetics of H 2 consumption over CeO 2 and Pt/CeO 2 with varying Pt loadings and structures to identify the elementary steps probed by H 2 -TPR. Literature often attributes changes in H 2 -TPR characteristics with Pt addition to increased CeO 2 reducibility. However, our analysis revealed that the H 2 consumption rate is measurement of the rate of H-spillover at Pt-CeO 2 interfaces and is determined by the concentration of Pt species on Pt nanoclusters that dissociate H 2 . Therefore, lower temperature H 2 consumption observed with Pt addition does not indicate higher CeO 2 reducibility. Measurements on samples with mixtures of Pt single-atoms and nanoclusters demonstrated that H 2 -TPR can effectively quantify dilute Pt nanocluster concentrations, suggesting caution in directly linking H 2 -TPR characteristics to oxide reducibility while highlighting alternative material insights that can be gleaned.}, archive = {J_ANGEW}, author = {Jaeha Lee and Phillip Christopher}, doi = {10.1002/anie.202414388}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414388}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Does h2 temperature-programmed reduction always probe solid-state redox chemistry? the case of Pt/CeO2}, volume = {64}, year = {2025}, }
• (2025). π-extension of a multiple resonance core: Double helical and heptagon-embedded nanographenes. ANGEW, 64(2), e202414383. (www)

  @article{ , abstract = {Multiple resonance (MR) boron–nitrogen doped polycyclic aromatic hydrocarbons (BN-PAHs) have shown compelling thermally activated delayed fluorescence (TADF), surpassing those of their hydrocarbon analogues. However, the structural variety of π-extended BN-PAHs remains narrow. In this study, we synthesized three double helical BN-doped nanographenes (BN-NGs), 2 a – 2 c , and three heptagon-embedded BN-NGs, 1 a – 1 c , by π-extension of the MR core. During the formation of 2 a , a nanographene with one heptagon ( 1 a ) was obtained, whereas further dehydrocyclization of the [6]helicene units within 2 b and 2 c led to heptagon structures, yielding other two BN-NGs containing double heptagons ( 1 b and 1 c ). These BN-NGs ( 2 a – 2 c and 1 a – 1 c ) showed pronounced redshifts of 100–190 nm compared to the parent MR core, while preserving the TADF characteristics and prolonging the delayed fluorescence lifetime to the millisecond level. Furthermore, the integration of a heptagon ring into 1 a – 1 c expanded the conjugation, reduced the oxidation potentials, and yielded a more flexible framework compared to those of 2 a – 2 c . The enantiomers of 2 a – 2 c , 1 a , and 1 c were resolved and their chiroptical properties were studied. Notably, 1 a and 1 c exhibited increased chiroptical dissymmetry factors.}, archive = {J_ANGEW}, author = {Yang-Yang Ju and Liang-En Xie and Jiang-Feng Xing and Qing-Song Deng and Xuan-Wen Chen and Ling-Xi Huang and Guo-Hui Nie and Yuan-Zhi Tan and Bin Zhang}, doi = {10.1002/anie.202414383}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {π-extension of a multiple resonance core: Double helical and heptagon-embedded nanographenes}, volume = {64}, year = {2025}, }
• (2025). Photo-induced ultrafast charge transfer and air-stable radical formation in tetraphenylpyrene derivatives. ANGEW, 64(2), e202414374. (www)

  @article{ , abstract = {Stable organic radicals generated by photo-excitation hold applications in molecular switching devices and information storage. It remains challenging to develop photo-generated radical materials with rapid response and air stability in the solid state. Here, we report a structure based on 1,3,6,8-tetraphenylpyrene derivative (Py-TTAc) displaying photo-induced radicals with air stability in the solid state. Photo-induced electron transfer, exposed to a 365 nm ultraviolet lamp for 1 minute, affords radicals in Py-TTAc powder as confirmed by electron paramagnetic resonance (EPR) spectroscopy. The maximum radical concentration reaches 2.21 % after continuous irradiation for 1 hour and recurs more than 10 times without any chemical degradation. The mechanistic study according to the femtosecond transient absorption (fsTA) and X-ray technology suggests that the radicals are derived from photo-induced symmetry-breaking charge separation (SB-CS) and stabilized through non-covalent interactions. The photo-generated stable radical system is employed in anti-counterfeiting paper and optoelectronic device applications. This study will provide insights into the development of photoactive organic radical materials.}, archive = {J_ANGEW}, author = {Lu Tang and Yuhang Gao and Nannan Cong and Zhiyuan Cui and Ming Zhang and Feng Li}, doi = {10.1002/anie.202414374}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414374}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-induced ultrafast charge transfer and air-stable radical formation in tetraphenylpyrene derivatives}, volume = {64}, year = {2025}, }
• (2025). Anisotropic hollow structure with chemotaxis enabling intratumoral autonomic therapy. ANGEW, 64(2), e202414370. (www)

  @article{ , abstract = {Effective intratumoral drug penetration is pivotal for successful cancer treatment. However, due to the disrupted capillary networks and poor perfusion in solid tumors, there exist challenges to realize autonomous directional drug penetration and controlled drug release within the tumor. Considering the specificity of glucose within tumor tissue, we draw inspiration from nature and engineer asymmetrical hollow structures exhibiting chemotaxis towards high glucose levels. By incorporating multiple shells into these structures, we enhance the local chemical concentration gradients, thereby improving cellular uptake and precise targeting. The advantages of anisotropic hollow multishell structure ( a -HoMS) can be reflected from the diffusion coefficient and directivity, which increase by 73.4 % and 273 % respectively compared to conventional isotropic hollow spheres, achieving the most linear movement while ensuring the speed of movement. Furthermore, the multi-level porosity and temporal-spatial order of a -HoMS enable sequential drug delivery that inhibits angiogenesis with inducing cell apoptosis. After the eradication of localized tumor cells, the a -HoMS can automatically migrate to the alive tumor cells under the glucose gradient, inducing another cycle of drug delivery and chemotaxis, resulting in excellent antitumor efficacy. These anisotropic HoMS demonstrate intelligence, adaptability, and precision in tumor therapy, providing valuable insights for programmable treatment within tissues.}, archive = {J_ANGEW}, author = {Ping Hou and Lingeng Xie and Ludan Zhang and Xin Du and Decai Zhao and Yuguang Wang and Nailiang Yang and Dan Wang}, doi = {10.1002/anie.202414370}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414370}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anisotropic hollow structure with chemotaxis enabling intratumoral autonomic therapy}, volume = {64}, year = {2025}, }
• (2025). Anion-regulated ionic covalent organic frameworks for highly selective recovery of gold from E-waste. ANGEW, 64(2), e202414366. (www)

  @article{ , abstract = {The existing electronic waste (e-waste) and leaching solutions generated by industries accumulate significant amounts of gold (Au), even in excess of those in natural minerals. Therefore, the recycling of Au is extremely significant for the potential sustainability of chemical industry. By designing ionic covalent organic frameworks (COFs), here we synthesize a series of Ionic-COF-X (X=Cl − , Br − , AcO − , and SO 4 2− ) by anion regulation strategy and further explore their adsorption performance towards Au recovery. All these ionic COFs exhibit ultrahigh gold adsorption efficiency and excellent regeneration. Moreover, anion regulation could indeed affect the Au capture performance. In particular, when Cl − ions serve as counter ions, the Au capacity of Ionic-COF-Cl could reach 1270.8 mg g −1 . Moreover, in the actual CPU leaching solution test, the selectivity of Ionic-COF-Cl towards Au 3+ ion hits 39000 and 4600 times higher than that of Cu 2+ and Ni 2+ ions, respectively, suggesting that the Ionic-COF-Cl is a promising material for highly selective recovering gold from actual e-waste. DFT calculations further reveal that counter ions can regulate the adsorption affinity of ionic COF framework toward Au. In short, this work provides a useful anion regulation strategy to design ionic COFs as a promising platform for gold selective recovery from actual e-waste.}, archive = {J_ANGEW}, author = {Jie Zhao and Zelong Qiao and Yuncheng He and Rui Zhang and Han Li and Xuezhen Song and Dapeng Cao and Shitao Wang}, doi = {10.1002/anie.202414366}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414366}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion-regulated ionic covalent organic frameworks for highly selective recovery of gold from E-waste}, volume = {64}, year = {2025}, }
• (2025). Improving the lithography sensitivity of atomically precise tin-oxo nanoclusters via heterometal strategy. ANGEW, 64(2), e202414360. (www)

  @article{ , abstract = {Tin-oxo clusters are increasingly recognized as promising materials for nanolithography technology due to their unique properties, yet their structural impacts on lithography performance remain underexplored. This work explores the structural impacts of heterometal strategies on the performance of tin-oxo clusters in nanolithography, focusing on various metal dopants and their coordination geometries. Specifically, SnOC-1(In) , SnOC-1(Al) , SnOC-1(Fe) , and SnOC-2 were synthesized and characterized. These clusters demonstrate excellent solubility, dispersibility, and stability, facilitating the preparation of high-quality films via spin-coating for lithographic applications. Notably, this work innovatively employs Atomic Force Microscopy-based Infrared Spectroscopy (AFM-IR), neutron reflectivity (NR), and X-ray reflectivity (XRR) measurements to confirm film homogeneity. Upon electron beam lithography (EBL), all four materials achieve 50 nm line patterns, with SnOC-1(In) demonstrating the highest lithography sensitivity. This enhanced sensitivity is attributed to indium dopants, which possess superior EUV absorption capabilities and unsaturated coordination environments. Further studies on exposure mechanisms indicated that Sn−C bond cleavage generates butyl free radicals, promoting network formations that induce solubility-switching behaviors for lithography. These findings underscore the efficacy of tailored structural design and modulation of cluster materials through heterometal strategies in enhancing lithography performance, offering valuable insights for future material design and applications.}, archive = {J_ANGEW}, author = {Weizhou Chen and Liming Wang and Zi-Rui Wang and Tao Zhu and Yuting Ye and Qiao-Hong Li and Xiaofeng Yi and Jian Zhang}, doi = {10.1002/anie.202414360}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414360}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Improving the lithography sensitivity of atomically precise tin-oxo nanoclusters via heterometal strategy}, volume = {64}, year = {2025}, }
• (2025). Photo-activation of tolane-based synthetic ion channel for transmembrane chloride transport. ANGEW, 64(2), e202414354. (www)

  @article{ , abstract = {While natural channels respond to external stimuli to regulate ion concentration across cell membranes, creating a synthetic version remains challenging. Here, we present a photo-responsive uncaging technique within an artificial ion channel system, which activates the ion transport process from a transport-inactive o -nitrobenzyl-based caged system. From the comparative ion transport screening, 1 b emerged as the most active transporter. Interestingly, its bis( o -nitrobenzyl) derivative, i.e., protransporter 1 b′ was inefficient in transporting ions. Detailed transport studies indicated that compound 1 b is an anion selective transporter with a prominent selectivity towards chloride ions by following the antiport mechanism. Compound 1 b′ did not form an ion channel, but after the o -nitrobenzyl groups were photocleaved, it released 1 b , forming a transmembrane ion channel. The channel exhibited an average diameter of 6.5±0.2 Å and a permeability ratio of . The geometry-optimization of protransporter 1 b′ indicated significant non-planarity, corroborating its inefficient self-assembly. In contrast, the crystal structure of 1 b demonstrates strong self-assembly via the formation of an intermolecular H-bond. Geometry optimization studies revealed the plausible self-assembled channel model and the interactions between the channel and chloride ion.}, archive = {J_ANGEW}, author = {Sandip Chattopadhayay and Kshitij V. Banzal and Pinaki Talukdar}, doi = {10.1002/anie.202414354}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414354}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photo-activation of tolane-based synthetic ion channel for transmembrane chloride transport}, volume = {64}, year = {2025}, }
• (2025). A microrobotic system based on engineered bacteria for targeted self-driven photodynamic therapy. ANGEW, 64(2), e202414347. (www)

  @article{ , abstract = {Photodynamic therapy (PDT) has been used clinically to treat superficial tumors for decades. However, its effectiveness against deep-seated tumors has been limited by the inefficient delivery of the key components -light, photosensitizer, and oxygen- required for the photochemical reactions in PDT. Here, we present a novel platform that enables the photochemical reaction to occur in a self-driven manner, eliminating the need for external delivery of these components and instead orchestrating their endogenous generation within tumors. This was achieved by genetically modifying probiotic Escherichia coli to host three modules - Lux, Hem1, and KatG - responsible for light production, photosensitizer biosynthesis, and oxygen generation, respectively. The system is self-driven, relying solely on substrates within E. coli cells and tumors. The modules exhibited prolonged activity for days within in vivo mouse models, enabling metronomic PDT that induced an immune response. This research holds promise for revolutionizing PDT and overcoming the enduring challenges encountered in its application for treating deep-seated tumors.}, archive = {J_ANGEW}, author = {Kai Jin and Lin Yu and Yue Zhang and Luqi Niu and Yi Huang and Yong Zhang and Yihan Wu}, doi = {10.1002/anie.202414347}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414347}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A microrobotic system based on engineered bacteria for targeted self-driven photodynamic therapy}, volume = {64}, year = {2025}, }
• (2025). A low-acidity chloride electrolyte enables exceptional reversibility and stability in aqueous tin metal batteries. ANGEW, 64(2), e202414346. (www)

  @article{ , abstract = {Tin (Sn) metal has emerged as a promising anode for aqueous batteries, due to its high capacity, non-toxicity, and cost-effectiveness. However, Sn metal has often been coupled with strong and corrosive sulfuric acids (2–3 M), leading to severe electrode corrosion and hydrogen evolution issues. Although high efficiency and long cycling were reported, the results were achieved using high currents to kinetically mask electrode-electrolyte side reactions. Herein, we introduce a low-acidity tin chloride electrolyte (pH=1.09) as a more viable option, which eliminates the need of strong acids and enables a reversible dendrite-free Sn plating chemistry. Remarkably, the plating efficiency approaches unity (99.97 %) under standard testing conditions (1 mA cm −2 for 1 mAh cm −2 ), which maintains high at 99.23–99.93 % across various aggressive conditions, including low current (0.1–0.25 mA cm −2 ), high capacity (5–10 mAh cm −2 ), and extended resting time (24–72 hours). The battery calendar life is further prolonged to 3064 hours, significantly surpassing literature reports. Additionally, we presented an effective method to mitigate the potential Sn 2+ oxidization issue on the cathode, demonstrating long-cycling Sn||LiMn 2 O 4 hybrid batteries. This work offers critical insights for developing highly reversible Sn metal batteries.}, archive = {J_ANGEW}, author = {Songyang Chang and Wentao Hou and Angelica Del Valle-Perez and Irfan Ullah and Shen Qiu and Jeileen Luciano Rodriguez and Liz M. Díaz-Vázquez and Lisandro Cunci and Gerardo Morell and Xianyong Wu}, doi = {10.1002/anie.202414346}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414346}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A low-acidity chloride electrolyte enables exceptional reversibility and stability in aqueous tin metal batteries}, volume = {64}, year = {2025}, }
• (2025). Enantioselective synthesis of α-aryl ketones by a cobalt-catalyzed semipinacol rearrangement. ANGEW, 64(2), e202414342. (www)

  @article{ , abstract = {A highly enantioselective cobalt-catalyzed semipinacol rearrangement of symmetric α,α-diarylallylic alcohols is disclosed. A chiral cobalt-salen catalyst generates a highly electrophilic carbocation surrogate following hydrogen atom transfer and radical–polar crossover steps. This methodology provides access to enantioenriched α-aryl ketones through invertive displacement of a cobalt(IV) complex during 1,2-aryl migration. A combination of readily available reagents, silane and N -fluoropyridinium oxidant, are used to confer this type of reactivity. An exploration into the effect of aryl substitution revealed the reaction tolerates para- and meta- halogenated, mildly electron-rich and electron-poor aromatic rings with excellent enantioselectivities and yields. The yield of the rearrangement diminished with highly electron-rich aryl rings whereas very electron-deficient and ortho -substituted arenes led to poor enantiocontrol. A Hammett analysis demonstrated the migratory preference for electron-rich aromatic rings, which is consistent with the intermediacy of a phenonium cation.}, archive = {J_ANGEW}, author = {Panagiotis G. Kalomenopoulos and Balakumar Emayavaramban and Craig P. Johnston}, doi = {10.1002/anie.202414342}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414342}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective synthesis of α-aryl ketones by a cobalt-catalyzed semipinacol rearrangement}, volume = {64}, year = {2025}, }
• (2025). Concise and modular chemoenzymatic total synthesis of bisbenzylisoquinoline alkaloids. ANGEW, 64(2), e202414340. (www)

  @article{ , abstract = {The bisbenzylisoquinoline alkaloids (bisBIAs) have attracted tremendous attention from the synthetic community due to their diverse and intriguing biological activities. Herein, we report the convergent and modular chemoenzymatic syntheses of eight bisBIAs bearing various substitutes and linkages in 5–7 steps. The gram-scale synthesis of various well-designed enantiopure benzylisoquinoline monomers was accomplished through an enzymatic stereoselective Pictet–Spengler reaction, followed by regioselective enzymatic methylation or chemical functionalization in a sequential one-pot process. A modified intermolecular copper-mediated Ullmann coupling enabled the concise and efficient total synthesis of five different linear bisBIAs with either head-to-tail or tail-to-tail linkage. A biomimetic oxidative phenol dimerization selectively formed the sterically hindered, electron-rich diaryl ether bond, and subsequent intramolecular Suzuki–Miyaura domino reaction or Ullmann coupling facilitated the first enantioselective total synthesis of three macrocyclic bisBIAs, including ent -isogranjine, tetrandrine and O -methylrepandine. This study highlights the great potential of chemoenzymatic strategies in the total synthesis of diverse bisBIAs and paves the way to further explore the biological functions of these natural products.}, archive = {J_ANGEW}, author = {Jin Wang and Jianxiong Zhao and Zhenyang Yu and Siyuan Wang and Fusheng Guo and Jun Yang and Lei Gao and Xiaoguang Lei}, doi = {10.1002/anie.202414340}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414340}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concise and modular chemoenzymatic total synthesis of bisbenzylisoquinoline alkaloids}, volume = {64}, year = {2025}, }
• (2025). Halogen-driven single-crystal to single-crystal transformation engineering the cluster-based spin crossover frameworks. ANGEW, 64(2), e202414330. (www)

  @article{ , abstract = {Cluster-based spin crossover (SCO) frameworks are a new class of smart metal–organic frameworks (MOFs) with diverse structures and topologies and unique bistable physicochemical properties. Here, we report a cluster-based SCO framework [Fe 3 {Ag 4 (CN) 6 (H 2 O)} 2 (TPBA) 3 ](ClO 4 ) 2 ⋅ 7DMF ( 1 ) with an extremely rare 3,4,6-T108 topology, in which the tripodal [Ag{Ag(CN) 2 } 3 (H 2 O)] 2− clusters axially link the Fe 2+ ions to form 2D→3D n -fold Borromean entangled networks. Under the guidance of reticular chemistry, the post-synthetic modification (PSM) from 1 with 3,4,6-T108 topology to [Fe 3 {Ag 8 X 8 (CN) 6 }(TPBA) 3 ] ( 2_X , X=Cl, Br, I) with urk topology is firstly achieved via single-crystal to single-crystal (SCSC) transformation. Moreover, the successive SCSC transformations from 2_Cl to 2_Br and then to 2_I are realized for the first time. Their SCO behaviors are also modified by halogen-driven stepwise cluster transformations. Hence, these findings provide new strategies for the development of cluster-based SCO MOFs towards the smart functional porous materials.}, archive = {J_ANGEW}, author = {Guang Yang and Ze-Yu Ruan and Yan-Cong Chen and Pei-Yu Liao and Si-Guo Wu and Zhao-Ping Ni and Ming-Liang Tong}, doi = {10.1002/anie.202414330}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414330}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halogen-driven single-crystal to single-crystal transformation engineering the cluster-based spin crossover frameworks}, volume = {64}, year = {2025}, }
• (2025). Specifically editing cancer sialoglycans for enhanced in vivo immunotherapy through aptamer-enzyme chimeras. ANGEW, 64(2), e202414327. (www)

  @article{ , abstract = {Immune checkpoint blockade (ICB) therapies have demonstrated remarkable clinical success in treating cancer. However, their objective response rate remains suboptimal because current therapies rely on limited immune checkpoints that fail to cover the multiple immune evasion pathways of cancer. To explore potential ICB strategies, we propose a glycoimmune checkpoint elimination (glycoICE) therapy based on targeted editing of sialoglycans on the tumor cell surface using an aptamer-enzyme chimera (ApEC). The ApEC can be readily generated via a one-step bioorthogonal procedure, allowing for large-scale and uniform production. It specifically targets and desialylates cancer cells, disrupting the sialoglycan-Siglec axis to activate immune cells and enhance immunotherapy efficacy, while its high tumor selectivity minimizes side effects from indiscriminate desialylation of normal tissues. Furthermore, the ApEC has the potential to be a versatile platform for specific editing of sialoglycans in different tumor models by adjusting the aptamer sequences to target specific protein markers. This research not only introduces a novel molecular tool for the effective editing of sialoglycans in complex environments, but also provides valuable insights for advancing DNA-based drugs towards in vivo and clinical applications.}, archive = {J_ANGEW}, author = {Qin Liu and Hang Xing and Mengyi Xiong and Xiao-Bing Zhang}, doi = {10.1002/anie.202414327}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414327}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Specifically editing cancer sialoglycans for enhanced in vivo immunotherapy through aptamer-enzyme chimeras}, volume = {64}, year = {2025}, }
• (2025). In situ cyclization of aromatic thioethers in emissive materials to generate phosphorescent dibenzothiophenes. ANGEW, 64(2), e202414326. (www)

  @article{ , abstract = {In this contribution, we explored the photocyclization of thioethers to highly substituted dibenzothiophenes (DBT) using solely UV-light without any need for additives. This cost-effective, robust and environmentally friendly approach yielded phosphorescent compounds, which were characterized by X-ray crystallography and state-of-the-art photophysical methods. The resulting DBTs feature ultralong photoluminescence lifetimes and quantum yields close to unity in frozen glassy matrices. The reaction mechanism was elucidated in detail through a combination of quantum chemical calculations and experimental results, providing evidence that triplet states are involved in the cyclization process. Additionally, the photoreaction can also be induced within materials. For this purpose, the precursors were integrated into polymer films or polymer resins suitable for 3D printing. Irradiation of these polymeric objects allows motifs with ultralong phosphorescence to be irreversibly inscribed through the proceeding photocyclization. The in situ photogeneration of DBTs from aromatic thioethers overcomes the observed incompatibilities regarding solubility in polymer resins for 3D printing.}, archive = {J_ANGEW}, author = {Marco Schmiedtchen and Iván Maisuls and Hannah Siera and Jan Balszuweit and Christoph Wölper and Michael Giese and Gebhard Haberhauer and Cristian A. Strassert and Jens Voskuhl}, doi = {10.1002/anie.202414326}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414326}, shortjournal = {Angew. Chem. Int. Edit.}, title = {In situ cyclization of aromatic thioethers in emissive materials to generate phosphorescent dibenzothiophenes}, volume = {64}, year = {2025}, }
• (2025). Structures of a DNA polymerase caught while incorporating responsive dual-functional nucleotide probes. ANGEW, 64(2), e202414319. (www)

  @article{ , abstract = {Functionalizing nucleic acids using DNA polymerases is essential in biophysical and biotechnology applications. This study focuses on understanding how DNA polymerases recognize and incorporate nucleotides with diverse chemical modifications, aiming to develop advanced nucleotide probes. We present the crystal structures of ternary complexes of Thermus aquaticus DNA polymerase (KlenTaq) with C5-heterocycle-modified environment-sensitive 2′-deoxyuridine-5′-triphosphate (dUTP) probes. These nucleotides include SedUTP, BFdUTP and FBFdUTP, which bear selenophene, benzofuran and fluorobenzofuran, respectively, at the C5 position of uracil, and exhibit high conformational sensitivity. SedUTP and FBFdUTP serve as dual-app probes, combining a fluorophore with X-ray anomalous scattering Se or 19 F NMR labels. Our study reveals that the size of the heterocycle influences how DNA polymerase families A and B incorporate these modified nucleotides during single nucleotide incorporation and primer extension reactions. Remarkably, the responsiveness of FBFdUTP enabled real-time monitoring of the binary complex formation and polymerase activity through fluorescence and 19 F NMR spectroscopy. Comparative analysis of incorporation profiles, fluorescence, 19 F NMR data, and crystal structures of ternary complexes highlights the plasticity of the enzyme. Key insight is provided into the role of gatekeeper amino acids (Arg660 and Arg587) in accommodating and processing these modified substrates, offering a structural basis for next-generation nucleotide probe development.}, archive = {J_ANGEW}, author = {Pulak Ghosh and Karin Betz and Cédric Gutfreund and Arindam Pal and Andreas Marx and Seergazhi G. Srivatsan}, doi = {10.1002/anie.202414319}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414319}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structures of a DNA polymerase caught while incorporating responsive dual-functional nucleotide probes}, volume = {64}, year = {2025}, }
• (2025). Heterochiral π-stacking dimerization of helical secondary structures with emerging supramolecular chirality. ANGEW, 64(2), e202414317. (www)

  @article{ , archive = {J_ANGEW}, author = {Wencan Li and Yiqi Shao and Zhaocheng Xu and Yunpeng Ge and Zhenzhu Wang and Hua Jiang and Zeyuan Dong}, doi = {10.1002/anie.202414317}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414317}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterochiral π-stacking dimerization of helical secondary structures with emerging supramolecular chirality}, volume = {64}, year = {2025}, }
• (2025). Screening of silver-based single-atom alloy catalysts for NO electroreduction to NH3 by DFT calculations and machine learning. ANGEW, 64(2), e202414314. (www)

  @article{ , abstract = {Exploring NO reduction reaction (NORR) electrocatalysts with high activity and selectivity toward NH 3 is essential for both NO removal and NH 3 synthesis. Due to their superior electrocatalytic activities, single-atom alloy (SAA) catalysts have attracted considerable attention. However, the exploration of SAAs is hindered by a lack of fast yet reliable prediction of catalytic performance. To address this problem, we comprehensively screened a series of transition-metal atom doped Ag-based SAAs. This screening process involves regression machine learning (ML) algorithms and a compressed-sensing data-analytics approach parameterized with density-functional inputs. The results demonstrate that Cu/Ag and Zn/Ag can efficiently activate and hydrogenate NO with small Φ max ( η ), a grand-canonical adaptation of the G max ( η ) descriptor, and exhibit higher affinity to NO over H adatoms to suppress the competing hydrogen evolution reaction. The NH 3 selectivity is mainly determined by the s orbitals of the doped single-atom near the Fermi level. The catalytic activity of SAAs is highly correlated with the local environment of the active site. We further quantified the relationship between the intrinsic features of these active sites and Φ max ( η ). Our work clarifies the mechanism of NORR to NH 3 and offers a design principle to guide the screen of highly active SAA catalysts.}, archive = {J_ANGEW}, author = {Jieyu Liu and Shuoao Wang and Yunyan Tian and Haiqiang Guo and Xing Chen and Weiwei Lei and Yifu Yu and Changhong Wang}, doi = {10.1002/anie.202414314}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414314}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Screening of silver-based single-atom alloy catalysts for NO electroreduction to NH3 by DFT calculations and machine learning}, volume = {64}, year = {2025}, }
• (2025). Bidirectional molecular motors by controlling threading and dethreading pathways of a linked rotaxane. ANGEW, 64(2), e202414307. (www)

  @article{ , abstract = {Artificial molecular motors have been presented as models for biological molecular motors. In contrast to the conventional artificial molecular motors that rely on covalent bond rotation, molecular motors with mechanically interlocked molecules (MIMs) have attracted considerable attention owing to their ability to generate significant rotational motion by dynamically shuttling macrocyclic components. The topology of MIM-type rotational molecular motors is currently limited to catenane structures, which require intricate synthetic procedures that typically produce a low synthetic yield. In this study, we develop a novel class of MIM-type molecular motors with a rotaxane-type topology. The switching of the threading/dethreading pathways of the linked rotaxane by protecting/deprotecting the bulky stopper group and changing the solvent polarity enables a net unidirectional rotation of the molecular motor. The threading/dethreading reaction rates were quantitatively evaluated through detailed spectroscopic investigations. Repeated net unidirectional rotation and switching of the direction of rotation were also achieved. Our findings demonstrate that linked rotaxanes can serve as MIM-type molecular motors with reversible rotational direction controlled by threading/dethreading reactions. These motors hold potential as components of molecular machinery.}, archive = {J_ANGEW}, author = {Hiromichi V. Miyagishi and Hiroshi Masai and Jun Terao}, doi = {10.1002/anie.202414307}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414307}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bidirectional molecular motors by controlling threading and dethreading pathways of a linked rotaxane}, volume = {64}, year = {2025}, }
• (2025). Simultaneous tailoring of chemical composition and morphology configuration in metal hexacyanoferrate for ultrafast and durable sodium-ion storage. ANGEW, 64(2), e202414302. (www)

  @article{ , abstract = {Metal hexacyanoferrates (MHCFs) with adjustable composition and open framework structures have been considered as intriguing cathode materials for sodium-ion batteries (SIBs). Exploiting MHCFs with ultrafast and durable sodium storage capability as well as comparable capacity is always a goal that many investigators pursue, but remains challenging. Herein, simultaneous tailoring of chemical composition and morphology configuration is carried out to design a hollow monoclinic high-entropy MHCF (HMHE-HCF) assembled by nanocubes for the first time to realize the objective. The “cocktail effect” of high-entropy construction, rich sodium content of monoclinic phase, and unique hollow structure endow HMHE-HCF cathode with fast reaction kinetics and energetically stable performance during continuous charging/discharging processes. As a result, the HMHE-HCF cathode demonstrates superior rate performance up to an ultra-high rate of 100 C (71.1 % retention to 0.1 C), and remarkable cycling stability with a capacity retention of 77.8 % over 25,000 cycles at 100 C, outperforming most reported sodium-ion cathodes. Further, the HMHE-HCF//hard carbon full-cell delivers capacities of 99.0 and 82.3 mAh g −1 at 0.1 C and 10 C, respectively, and retains 98.1 % of the initial capacity after 1,600 cycles at 5 C, demonstrating its potential application for sodium-ion storage.}, archive = {J_ANGEW}, author = {Hao Cheng and Huan Xu and Jian Shang and Yinan Xu and Haoming Zong and Wenjiao Yao and Zebo Fang and Weidong Dou and Luojiang Zhang and Yongbing Tang}, doi = {10.1002/anie.202414302}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414302}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Simultaneous tailoring of chemical composition and morphology configuration in metal hexacyanoferrate for ultrafast and durable sodium-ion storage}, volume = {64}, year = {2025}, }
• (2025). Concise synthesis of cyctetryptomycin a and b enabled by zr-catalyzed dimerization. ANGEW, 64(2), e202414295. (www)

  @article{ , abstract = {A concise synthetic strategy utilizing a Zr catalyst for the construction of cyctetryptomycin A and B is reported. Cyctetryptomycin A and B are recently isolated, complex tetrameric natural products for which total synthesis has not been previously reported. This study presents a practical approach for the construction of two consecutive quaternary carbon centers with a Zr catalyst. Furthermore, the first total synthesis of cyctetryptomycin A and B was achieved by this Zr-catalyzed radical coupling. The radical dimerization reaction mediated by the Zr catalyst required 1,2-bis(diphenylphosphino)ethane (dppe) as an indispensable additive. Through both experimental and theoretical investigations into the mechanism of this Zr-catalyzed reaction, the specific role of dppe was elucidated. In addition, the synthetic approach was extended to enable the practical synthesis of other dimeric natural products, including tetratryptomycin A, dibrevianamide F, and ditryptophenaline. Finally, the synthetic mechanism of cyctetryptomycin A and B, through the oxidative macrocyclization of tetratryptomycin A by CttpC, was newly elucidated by both experimental and docking simulations.}, archive = {J_ANGEW}, author = {Longhui Yu and Hiroshige Ogawa and Shangzhao Li and Tsoh Lam Cheung and Wenchao Liu and Dexiu Yan and Yudai Matsuda and Yusuke Kobayashi and Zhihong Guo and Kotaro Ikeda and Trevor A. Hamlin and Ken Yamazaki and Pei-Yuan Qian and Hugh Nakamura}, doi = {10.1002/anie.202414295}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414295}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Concise synthesis of cyctetryptomycin a and b enabled by zr-catalyzed dimerization}, volume = {64}, year = {2025}, }
• (2025). Dual metallosalen-based covalent organic frameworks for artificial photosynthetic diluted CO2 reduction. ANGEW, 64(2), e202414287. (www)

  @article{ , abstract = {Directly converting CO 2 in flue gas using artificial photosynthetic technology represents a promising green approach for CO 2 resource utilization. However, it remains a great challenge to achieve efficient reduction of CO 2 from flue gas due to the decreased activity of photocatalysts in diluted CO 2 atmosphere. Herein, we designed and synthesized a series of dual metallosalen-based covalent organic frameworks (MM-Salen-COFs, M: Zn, Ni, Cu) for artificial photosynthetic diluted CO 2 reduction and confirmed their advantage in comparison to that of single metal M-Salen-COFs. As a results, the ZnZn-Salen-COF with dual Zn sites exhibits a prominent visible-light-driven CO 2 -to-CO conversion rate of 150.9 μmol g −1 h −1 under pure CO 2 atmosphere, which is ~6 times higher than that of single metal Zn-Salen-COF. Notably, the dual metal ZnZn-Salen-COF still displays efficient CO 2 conversion activity of 102.1 μmol g −1 h −1 under diluted CO 2 atmosphere from simulated flue gas conditions (15 % CO 2 ), which is a record high activity among COFs- and MOFs-based photocatalysts under the same reaction conditions. Further investigations and theoretical calculations suggest that the synergistic effect between the neighboring dual metal sites in the ZnZn-Salen-COF facilitates low concentration CO 2 adsorption and activation, thereby lowering the energy barrier of the rate-determining step.}, archive = {J_ANGEW}, author = {Hong Dong and Liang Fang and Ke-Xin Chen and Jian-Xin Wei and Jia-Xin Li and Xiu Qiao and Ya Wang and Feng-Ming Zhang and Ya-Qian Lan}, doi = {10.1002/anie.202414287}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414287}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dual metallosalen-based covalent organic frameworks for artificial photosynthetic diluted CO2 reduction}, volume = {64}, year = {2025}, }
• (2025). Anchoring catalytic metal nodes within a single-crystalline pyrazolate metal-organic framework for efficient heterogeneous catalysis. ANGEW, 64(2), e202414271. (www)

  @article{ , abstract = {The synthesis of single-crystalline and robust pyrazolate metal–organic frameworks (Pz-MOFs) capable of facilitating challenging organic transformations is fundamentally significant in catalysis. Here we demonstrate a metal-node-based catalytic site anchoring strategy by synthesizing a single-crystalline and robust Pz-MOF (PCN-1004). PCN-1004 features one-dimensional (1D) copper-Pz chains interconnected by well-organized ligands, forming a porous three-dimensional (3D) network with two types of 1D open channels. Notably, PCN-1004 displays exceptional stability in aqueous solutions across a broad pH range (1 to 14), attributed to the robust copper-Pz coordination bond. Significantly, PCN-1004 functions as an outstanding catalyst in cross dehydrogenative coupling reactions for constructing C−O/C−S bonds, even in the absence of directing groups, achieving yields of up to ~99 %, with long cycle lives and high substrate compatibility. PCN-1004 outperforms all previously reported porphyrin-based homogeneous and heterogeneous catalysts. Control experiments and computations elucidate the pivotal catalytic role of the copper-Pz chains and reveal a free radical pathway for the reaction. This work not only demonstrates the successful implementation of a metal-node-based catalytic site anchoring strategy for the efficient catalysis of challenging organic transformations but also highlights the synergistic effect of a robust framework, 1D open channels, and active sites in enhancing catalytic efficiency within MOFs.}, archive = {J_ANGEW}, author = {Rong-Ran Liang and Zhaoyi Liu and Zongsu Han and Yihao Yang and Joshua Rushlow and Hong-Cai Zhou}, doi = {10.1002/anie.202414271}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414271}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anchoring catalytic metal nodes within a single-crystalline pyrazolate metal-organic framework for efficient heterogeneous catalysis}, volume = {64}, year = {2025}, }
• (2025). Direction modulation of intramolecular electric field boosts hole transport in phthalocyanines for perovskite solar cells. ANGEW, 64(2), e202414249. (www)

  @article{ , abstract = {Tuning the strength of intramolecular electric field (IEF) in conjugated molecules has emerged as an effective approach to boost charge transfer. While direction manipulation of IEF would be a potential way that is still unclear. Here, we leverage the control of peripheral substituents of conjugated phthalocyanines to chemically tune the spatial orientation of IEF. By analyzing the spatial swing of side chains using the Kolmogorov-Arnold representation and least squares algorithm, a comprehensive mathematical-physical model has been established. This model enables rapid evaluation of the IEF and maximum hole transport performance induced by spatial swings. The champion phthalocyanine as dopant-free hole transport material in perovskite solar cell realizes a record performance of 23.41 %. Greatly device stability is also exhibited. This work affords a new way to enhance hole transport capabilities of conjugated molecules by optimizing their IEF vector for photovoltaic devices.}, archive = {J_ANGEW}, author = {Guo-Bin Xiao and Xijiao Mu and Zhen-Yang Suo and Xukai Zhang and Zefeng Yu and Jing Cao}, doi = {10.1002/anie.202414249}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414249}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direction modulation of intramolecular electric field boosts hole transport in phthalocyanines for perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Transforming element sulfur to high performance closed-loop recyclable polymer via proton transfer enabled anionic hybrid copolymerization. ANGEW, 64(2), e202414244. (www)

  @article{ , abstract = {The utilization of sulfur has been a global issue. Copolymerization of element sulfur (S 8 ) with other monomers is a promising route to convert it to useful materials but is limited by the comonomers. Here, we report anionic hybrid copolymerization of S 8 with acrylate and epoxide at room temperature, where S 8 does not copolymerize with epoxide in the absence of acrylate. Yet, the proton transfer from the methyne in acrylate to the oxygen anion enables the ring-opening of the cyclic comonomer and hence the copolymerization. The cyclic comonomers can be expanded to lactone and cyclic carbonate. Specifically, the copolymer of S 8 with bisphenl A diglycidyl ether and diacrylate displays mechanical properties comparable to those of most common plastics, namely, it has ultimate tensile strength as high as 60.8 MPa and Young's modulus up to 680 MPa. It also exhibits high UV resistance and good transparency. Particularly, it has excellent UV-induced self-healing, reprocessability and closed-loop recyclability due to the abundant dynamic S−S bonds and ester groups. This study provides an efficient strategy to turn element sulfur into closed-loop recyclable polymer with high mechanical and optical performances.}, archive = {J_ANGEW}, author = {Hongjun Yang and Jikai Zhang and Wenyan Huang and Guangzhao Zhang}, doi = {10.1002/anie.202414244}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414244}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transforming element sulfur to high performance closed-loop recyclable polymer via proton transfer enabled anionic hybrid copolymerization}, volume = {64}, year = {2025}, }
• (2025). Time-encoded information encryption with pH clock guided broad-spectrum emission by dynamic assemblies. ANGEW, 64(2), e202414239. (www)

  @article{ , abstract = {With growing threats from counterfeiting-based security breaches, multi-level and specific stimuli-responsive anti-counterfeiting devices and message encryption methods have attracted immense research interest. Fluorescence-based encryption from aggregation-induced emission (AIE)-based materials solves the problems to a considerable extent. However, the development of smarter patterns with hierarchical security levels alongside dynamic display is still challenging. To screen out this complication, we bring forward a pH-switchable fluorescent assembly of an AIEgen and an aliphatic acid. We later temporally direct the molecular assembly with the aid of a chemical trigger-regulated pH clock, generating a transitory multicolor emission, including transient white light generation. The pH-dependent emissions were further implemented in constructing smart multi-input fluorescent chemical AND gates. Subsequently, we integrate the time-gated emissive system to develop an advanced multi-dimensionally secure data encryption strategy. This novel approach enhances anti-counterfeiting measures by introducing an additional layer of security based on temporal characteristics.}, archive = {J_ANGEW}, author = {Priyam Das and Tanushree Das and Suprotim Koley and Malay Kumar Baroi and Saurav Das and Jyotirmayee Mohanty and Debapratim Das}, doi = {10.1002/anie.202414239}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414239}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Time-encoded information encryption with pH clock guided broad-spectrum emission by dynamic assemblies}, volume = {64}, year = {2025}, }
• (2025). Mo migration-induced crystalline to amorphous conversion and formation of RuMo/NiMoO4 heterogeneous nanoarray for hydrazine-assisted water splitting at large current density. ANGEW, 64(2), e202414234. (www)

  @article{ , abstract = {Manipulating the atomic structure of the catalyst and tailoring the dissociative water-hydrogen bonding network at the catalyst-electrolyte interface is essential for propelling alkaline hydrogen evolution reaction (HER) and hydrazine oxidation reaction (HzOR), but remains a great challenge. Herein, we constructed an advanced a-RuMo/NiMoO 4 /NF heterogeneous electrocatalyst with amorphous RuMo alloy nanoclusters anchored to amorphous NiMoO 4 skeletons on Ni foam by a heteroatom implantation strategy. Theoretical calculations and in situ Raman tests show that the amorphous and alloying structure of a-RuMo/NiMoO 4 /NF not only induces the directional evolution of interfacial H 2 O, but also lowers the d-band center (from −0.43 to −2.22 eV) of a-RuMo/NiMoO 4 /NF, the Gibbs free energy of hydrogen adsorption (ΔG H* , from −1.29 to −0.06 eV), and the energy barrier of HzOR (ΔG N2(g) =1.50 eV to ΔG N2* =0.47 eV). Profiting from these favorable factors, the a-RuMo/NiMoO 4 /NF exhibits excellent electrocatalytic performances, especially at large current densities, with an overpotential of 13 and 129 mV to reach 10 and 1000 mA cm −2 for HER. While for HzOR, it needs only −91 and 276 mV to deliver 10 and 500 mA cm −2 , respectively. Further, the constructed a-RuMo/NiMoO 4 /NF||a-RuMo/NiMoO 4 /NF electrolyzer demands only 7 and 420 mV to afford 10 and 500 mA cm −2 .}, archive = {J_ANGEW}, author = {Yanan Chang and Lingyi Kong and Dongdong Xu and Xuyun Lu and Shasha Wang and Yafei Li and Jianchun Bao and Yu Wang and Ying Liu}, doi = {10.1002/anie.202414234}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414234}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mo migration-induced crystalline to amorphous conversion and formation of RuMo/NiMoO4 heterogeneous nanoarray for hydrazine-assisted water splitting at large current density}, volume = {64}, year = {2025}, }
• (2025). 2D/2D hydrogen-bonded organic Frameworks/Covalent organic frameworks S-scheme heterojunctions for photocatalytic hydrogen evolution. ANGEW, 64(2), e202414229. (www)

  @article{ , abstract = {Hydrogen-bonded organic frameworks (HOFs) demonstrate significant potential for application in photocatalysis. However, the low efficiency of electron-hole separation and limited stability inhibit their practical utilization in photocatalytic hydrogen evolution from water splitting. Herein, the novel dual-pyrene-base supramolecular HOF/COF 2D/2D S-scheme heterojunction between HOF-H 4 TBAPy (Py-HOF, H 4 TBAPy represents the 1,3,6,8-tetrakis (p-benzoic acid) pyrene) and Py-COF was successfully established using a rapid self-assembly solution dispersion method. Experimental and theoretical investigations confirm that the size-matching of two crystalline porous materials enables the integrated heterostructure material with abundant surface reaction sites, strong interaction, and an enhanced S-scheme built-in electric field, thus significantly improving the efficiency of photogenerated charge carrier separation and stability. Notably, the optimal HOF/COF heterojunction achieves a photocatalytic hydrogen evolution rate of 390.68 mmol g −1 h −1 , which is 2.28 times higher than that of pure Py-HOF and 9.24 times higher than that of pure COF. These findings precisely acquire valuable atomic-scale insights into the ingenious design of dual-pyrene-based S-scheme heterojunction. This work presents an innovative perspective for forming supramolecular S-scheme heterojunctions over HOF-based semiconductors, offering a protocol for designing the powerful and strong-coupling S-scheme built-in electric fields for efficient solar energy utilization.}, archive = {J_ANGEW}, author = {Ruiqi Gao and Rongchen Shen and Can Huang and Kaihui Huang and Guijie Liang and Peng Zhang and Xin Li}, doi = {10.1002/anie.202414229}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414229}, shortjournal = {Angew. Chem. Int. Edit.}, title = {2D/2D hydrogen-bonded organic Frameworks/Covalent organic frameworks S-scheme heterojunctions for photocatalytic hydrogen evolution}, volume = {64}, year = {2025}, }
• (2025). A grafting hydrogen-bonded organic framework for benchmark selectivity of C2H2/CO2 separation under ambient conditions. ANGEW, 64(2), e202414215. (www)

  @article{ , abstract = {Reticular chemistry and pore engineering have garnered significant advancements in metal–organic frameworks and covalent organic frameworks, leveraging robust metal-coordination and covalent bonds. However, these achievements remain elusive in hydrogen-bonded organic frameworks, hindered by their inherent weakness in hydrogen bonding. Herein, we strategically manipulate the porosity of hydrogen-bonded frameworks through a grafting approach, culminating in the synthesis of two isomorphic HOFs, HOF-FJU-99 and HOF-FJU-100, with distinct pore environments. Remarkably, HOF-FJU-100, with its microporous architecture, not only showcases exceptional stability but also achieves unparalleled separation efficiency and ultrahigh selectivity for C 2 H 2 /CO 2 mixtures (50/50, v/v) under ambient conditions. Its IAST selectivity value of 201 stands as a benchmark, towering over all previously reported HOFs. The pore of HOF-FJU-100 boasts an electrostatic potential highly favourable for C 2 H 2 adsorption, as evidenced by single crystal X-ray diffraction analysis revealing multiple hydrogen bonding interactions between C 2 H 2 molecules and the framework. In situ gas-carrier powder X-ray diffraction analysis underscores the adaptability of pore structure, dynamically adjusting its orientation in response to C 2 H 2 , thereby enabling a highly efficient and specific separation of C 2 H 2 /CO 2 mixtures through specific adsorptive interactions.}, archive = {J_ANGEW}, author = {Furong Yuan and Yunbin Li and Zhen Yuan and Lu Li and Chenxin Chen and Lei He and Hongyu Lin and Xi Fan and Banglin Chen and Shengchang Xiang and Zhangjing Zhang}, doi = {10.1002/anie.202414215}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414215}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A grafting hydrogen-bonded organic framework for benchmark selectivity of C2H2/CO2 separation under ambient conditions}, volume = {64}, year = {2025}, }
• (2025). Hypercrosslinked metal-organic polyhedra electrolyte with high transference number and fast conduction of li ions. ANGEW, 64(2), e202414211. (www)

  @article{ , abstract = {Solid-state electrolytes (SSEs) with high Li-ion transference numbers and fast ionic conductivity are urgently needed for technological innovations in lithium-metal batteries. To promote the dissociation of ion pairs and overcome the mechanical brittleness and interface defects caused by traditional fillers in polymeric electrolytes, we designed and fabricated a cationic hypercrosslinking metal-organic polyhedra (HCMOPs) polymer as SSE. Benefiting a three-component synergistic effect: cationic MOPs, branched polyethyleneimine macromonomer and polyelectrolyte units, the Li-HCMOP electrolyte possesses a high Li-ion conductivity, a high Li-ion transference number and a low activation energy. The LiFePO 4 /Li battery exhibits high capacity with superior rate performance and cycling stability. Moreover, soluble MOPs serve as high crosslinking nodes to provide excellent mechanical strength for electrolytes and good compatibility with polymers. This work highlights an effective idea of high-performance MOP-based solid-state electrolytes applied in LMBs.}, archive = {J_ANGEW}, author = {Jinjin Liu and Runhao Zhang and Xintai Xie and Juan Wang and Fazheng Jin and Zhifang Wang and Tonghai Wang and Peng Cheng and Jianhao Lu and Zhenjie Zhang}, doi = {10.1002/anie.202414211}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414211}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Hypercrosslinked metal-organic polyhedra electrolyte with high transference number and fast conduction of li ions}, volume = {64}, year = {2025}, }
• (2025). N-ZrS3/p-ZrOS photoanodes with NiOOH/FeOOH oxygen evolution catalysts for photoelectrochemical water oxidation. ANGEW, 64(2), e202414209. (www)

  @article{ , abstract = {Photoelectrochemical water splitting offers a promising approach for carbon neutrality, but its commercial prospects are still hampered by a lack of efficient and stable photoelectrodes with earth-abundant materials. Here, we report a strategy to construct an efficient photoanode with a coaxial nanobelt structure, comprising a buried-ZrS 3 /ZrOS n−p junction, for photoelectrochemical water splitting. The p-type ZrOS layer, formed on the surface of the n-type ZrS 3 nanobelt through a pulsed-ozone-treatment method, acts as a hole collection layer for hole extraction and a protective layer to shield the photoanode from photocorrosion. The resulting ZrS 3 /ZrOS photoanode exhibits light harvesting with good photo-to-current efficiencies across the whole visible region to over 650 nm. By further employing NiOOH/FeOOH as the oxygen evolution reaction cocatalyst, the ZrS 3 /ZrOS/NiOOH/FeOOH photoanode yields a photocurrent density of ~9.3 mA cm −2 at 1.23 V versus the reversible hydrogen electrode with an applied bias photon-to-current efficiency of ~3.2 % under simulated sunlight irradiation in an alkaline solution (pH=13.6). The conformal ZrOS layer enables ZrS 3 /ZrOS/NiOOH/FeOOH photoanode operation over 1000 hours in an alkaline solution without obvious performance degradation. This study, offering a promising approach to fabricate efficient and durable photoelectrodes with earth-abundant materials, advances the frontiers of photoelectrochemical water splitting.}, archive = {J_ANGEW}, author = {Zhangliu Tian and Meng Wang and Ganwen Chen and Jie Chen and Yumin Da and Hanqian Zhang and Rui Jiang and Yukun Xiao and Baihua Cui and Chonglai Jiang and Yishui Ding and Jinlin Yang and Zejun Sun and Cheng Han and Wei Chen}, doi = {10.1002/anie.202414209}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414209}, shortjournal = {Angew. Chem. Int. Edit.}, title = {N-ZrS3/p-ZrOS photoanodes with NiOOH/FeOOH oxygen evolution catalysts for photoelectrochemical water oxidation}, volume = {64}, year = {2025}, }
• (2025). Intrinsic activity identification of noble metal single-sites for electrocatalytic chlorine evolution. ANGEW, 64(2), e202414202. (www)

  @article{ , abstract = {Single-atom catalysts with maximal atom-utilization have emerged as promising alternatives for chlorine evolution reaction (CER) toward valuable Cl 2 production. However, understanding their intrinsic CER activity has so far been plagued due to the lack of well-defined atomic structure controlling. Herein, we prepare and identify a series of atomically dispersed noble metals (e.g., Pt, Ir, Ru) in nitrogen-doped nanocarbons (M 1 −N−C) with an identical M−N 4 moiety, which allows objective activity evaluation. Electrochemical experiments, operando Raman spectroscopy, and quasi-in situ electron paramagnetic resonance spectroscopy analyses collectively reveal that all the three M 1 −N−C proceed the CER via a direct Cl-mediated Vomer-Heyrovský mechanism with reactivity following the trend of Pt 1 −N−C>Ir 1 −N−C>Ru 1 −N−C. Density functional theory (DFT) calculations reveal that this activity trend is governed by the binding strength of Cl*−Cl intermediate (ΔG Cl*−Cl ) on M−N 4 sites (Pt<Ir<Ru) featuring distinct d-band centers, providing a reliable thermodynamic descriptor for rational design of single metal sites toward Cl 2 electrosynthesis.}, archive = {J_ANGEW}, author = {Li Quan and Xin Zhao and Li-Ming Yang and Bo You and Bao Yu Xia}, doi = {10.1002/anie.202414202}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414202}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intrinsic activity identification of noble metal single-sites for electrocatalytic chlorine evolution}, volume = {64}, year = {2025}, }
• (2025). Molecular design of mono-fluorinated ether-based electrolyte for all-climate lithium-ion batteries and lithium-metal batteries. ANGEW, 64(2), e202414201. (www)

  @article{ , abstract = {Fluorinated-ethers are promising electrolyte solvents in lithium metal batteries, for their high antioxidant and excellent reductive stability on Li anode. However, fluorinated-ethers with high fluorination degree suffer from low ionic conductivity and narrow temperature adaptibility. Herein, we synthesize a mono-fluorinated linear ether of bis(2-fluoroethoxy) methane (BFME) with enhanced solvated ability. The −OCH 2 O− structure and fluoride substitution on the β-C position endows the BFME electrolyte with moderate affinity to Li + , thereby improving the ionic conductivity and decreasing the Li + -desolvation energy barrier at a wide temperature range of −60–60 °C. Additionally, the electrolyte with anion-participated solvation structure demonstrates high film-forming ability by forming LiF-rich interfacial film on the electrode surfaces, rendering the graphite anode with an initial Coulombic efficiency (CE) of 94.9 % and a Li plating/stripping CE of 99.8 % by Aurbach method. Consequently, the Graphite||LiFePO 4 pouch cells delivered 83.2 %, 92.5 % and 81.2 % capacity retention after 1250, 200 and 300 cycles at 25, −20 °C and 60 °C, respectively. Moreover, the Li||LFP pouch cell with 3 Ah capacity can operate for 65 cycles with 99 % capacity retention, verifying the effectiveness of the BFME electrolyte in stabilizing the interfaces and broadening the temperature adaptibility of lithium-ion and lithium metal batteries.}, archive = {J_ANGEW}, author = {Yejuan Xue and Yueda Wang and Heng Zhang and Weilong Kong and Yuxin Zhou and Bo Kang and Zhimei Huang and Hongfa Xiang}, doi = {10.1002/anie.202414201}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414201}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular design of mono-fluorinated ether-based electrolyte for all-climate lithium-ion batteries and lithium-metal batteries}, volume = {64}, year = {2025}, }
• (2025). Small-molecule mixed ionic-electronic conductors for efficient N-type electrochemical transistors: Structure-function correlations. ANGEW, 64(2), e202414180. (www)

  @article{ , abstract = {The fundamental challenge in electron-transporting organic mixed ionic-electronic conductors (OMIECs) is simultaneous optimization of electron and ion transport. Beginning from Y6-type/U-shaped non-fullerene solar cell acceptors, we systematically synthesize and characterize molecular structures that address the aforementioned challenge, progressively introducing increasing numbers of oligoethyleneglycol (OEG; g) sidechains from 1 g to 3 g, affording OMIECs 1gY, 2gY, and 3gY, respectively. The crystal structure of 1gY preserves key structural features of the Y n series: a U-shaped/planar core, close π–π molecular stacking, and interlocked acceptor groups. Versus inactive Y6 and Y11, all of the new glycolated compounds exhibit mixed ion-electron transport in both conventional organic electrochemical transistor (cOECT) and vertical OECT (vOECT) architectures. Notably, 3gY with the highest OEG density achieves a high transconductance of 16.5 mS, an on/off current ratio of ~10 6 , and a turn-on/off response time of 94.7/5.7 ms in vOECTs. Systematic optoelectronic, electrochemical, architectural, and crystallographic analysis explains the superior 3gY-based OECT performance in terms of denser n gY OEG content, increased crystallite dimensions with decreased long-range crystalline order, and enhanced film hydrophilicity which facilitates ion transport and efficient redox processes. Finally, we demonstrate an efficient small-molecule-based complementary inverter using 3gY vOECTs, showcasing the bioelectronic applicability of these new small-molecule OMIECs.}, archive = {J_ANGEW}, author = {Yongjoon Cho and Lin Gao and Yao Yao and Jaehyun Kim and Dayong Zhang and Giacomo Forti and Isaiah Duplessis and Yuyang Wang and Robert M. Pankow and Xudong Ji and Jonathan Rivnay and Tobin J. Marks and Antonio Facchetti}, doi = {10.1002/anie.202414180}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414180}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Small-molecule mixed ionic-electronic conductors for efficient N-type electrochemical transistors: Structure-function correlations}, volume = {64}, year = {2025}, }
• (2025). Unraveling C-selective ring-opening of phosphiranes with carboxylic acids and other nucleophiles: A mechanistically-driven approach. ANGEW, 64(2), e202414172. (www)

  @article{ , abstract = {Phosphiranes are weak Lewis bases reacting with only a limited number of electrophiles to produce the corresponding phosphiranium ions. These salts are recognized for their propensity to undergo reactions with oxygen pronucleophiles at the phosphorus site, leading to the formation of phosphine oxide adducts. Building on a thorough mechanistic understanding, we have developed an unprecedented approach that enables the selective reaction of carboxylic acids, and other nucleophiles, at the carbon site of phosphiranes. This method involves the photochemical generation of highly reactive carbenes, which react with 1-mesitylphosphirane to yield ylides. The latter undergoes a stepwise reaction with carboxylic acids, resulting in the production of the desired phosphines. In addition to DFT calculations, we have successfully isolated and fully characterized the key intermediates involved in the reaction.}, archive = {J_ANGEW}, author = {Avisek Ghosh and Thi Hong Van Nguyen and Corentin Bellanger and Saloua Chelli and Mohammad Ahmad and Nathalie Saffon-Merceron and Catherine Taillier and Vincent Dalla and Robert J. Mayer and Isabelle M. Dixon and Sami Lakhdar}, doi = {10.1002/anie.202414172}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414172}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling C-selective ring-opening of phosphiranes with carboxylic acids and other nucleophiles: A mechanistically-driven approach}, volume = {64}, year = {2025}, }
• (2025). Pyrrolic-nitrogen chemistry in 1-(2-hydroxyethyl)imidazole electrolyte additives toward a 50,000-cycle-life aqueous zinc-iodine battery. ANGEW, 64(2), e202414166. (www)

  @article{ , abstract = {Rechargeable aqueous zinc iodine (Zn-I 2 ) batteries offer benefits such as low cost and high safety. Nevertheless, their commercial application is hindered by hydrogen evolution reaction (HER) and polyiodide shuttle, which result in a short lifespan. In this study, 1-(2-hydroxyethyl)imidazole (HEI) organic molecules featuring pyrrole-N groups are introduced as dually-functional electrolyte additives to simultaneously stabilize Zn anode and confine polyiodide through ion-dipole interactions. The pyrrole-N groups in HEI can preserve the interfacial pH equilibrium at Zn anode by reversibly capturing H + ions and dynamically neutralizing OH − ions, thereby suppressing the HER. Notably, the H 2 evolution rate at the Zn anode is reduced to a mere 2.20 μmol h −1 cm −2 . Furthermore, the pyrrole-N moieties in HEI effectively curtail the polyiodide shuttle at I 2 cathode, which show adsorption energies of −0.174 eV for I 2 , −0.521 eV for I 3 − , and −0.768 eV for I − , as indicated by density functional theory calculations. Electrochemical testing demonstrates that the Zn//Zn symmetric cell maintains stable cycling for up to 4,200 hours at 1 mA cm −2 . Most strikingly, at a high I 2 mass loading of 9.7 mg cm −2 , the Zn-I 2 battery achieves an extraordinary cycle life of 50,000 cycles.}, archive = {J_ANGEW}, author = {Jiajun Chen and Genyuan Ou and Peifen Liu and Wenju Fan and Bing Li and Zuyang Hu and Zhipeng Wen and Yufei Zhang and Yongchao Tang and Xiaoqing Liu and Minghui Ye and Cheng Chao Li}, doi = {10.1002/anie.202414166}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414166}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Pyrrolic-nitrogen chemistry in 1-(2-hydroxyethyl)imidazole electrolyte additives toward a 50,000-cycle-life aqueous zinc-iodine battery}, volume = {64}, year = {2025}, }
• (2025). Divergent tandem acyl carrier proteins necessitate in-series polyketide processing in the leinamycin family. ANGEW, 64(2), e202414165. (www)

  @article{ , abstract = {The leinamycin family of polyketides are promising antitumor antibiotics, yet several aspects of their biosynthesis remain elusive. All leinamycin family members bear a sulfur-containing moiety which is essential for the anticancer activity exhibited by leinamycin. The key building blocks required for the incorporation of these functionalities are introduced in the final module of the polyketide synthase (PKS), which elegantly combines β-branching and thiocysteine incorporation to generate a diverse library of sulfur-based molecular scaffolds. Two acyl carrier proteins (ACPs) form a key didomain component of this module, but their amino acid sequence divergence has brought into question the common notion of functional equivalence. Here, we provide unprecedented functional evidence that these tandem ACPs play distinct roles in the final module of polyketide assembly. Using the weishanmycin biosynthetic pathway as a template, the in vitro reconstitution of key polyketide chain extension and β-branching steps in this module has revealed strict functional selectivity for a single ACP. Furthermore, we propose a cryptic transacylation step must occur prior to polyketide off-loading and cyclization. Altogether, these mechanistic investigations suggest that an atypical in-series mechanism underpins sulfur incorporation in the leinamycin family, and provides significant progress towards delineating their late-stage assembly.}, archive = {J_ANGEW}, author = {Annabel P. Phillips and Ashley J. Winter and Chloe M. Hooper and Christopher Williams and John Crosby and Christine L. Willis and Matthew P. Crump}, doi = {10.1002/anie.202414165}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414165}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Divergent tandem acyl carrier proteins necessitate in-series polyketide processing in the leinamycin family}, volume = {64}, year = {2025}, }
• (2025). Establishing a robust nonlinear targeted switch for c1 electroproduction in atomic alloy Cox/Pd bimetallenes. ANGEW, 64(2), e202414163. (www)

  @article{ , abstract = {Establishing a targeted switch for CO 2 conversion under electric drive is essential for achieving carbon-balance by enabling selective chemicals. However, engineering the topological assembly of active sites to precisely regulate the competing pathways for various intermediates has been plagued by unclear structure-function relationships. To tailor the CO/formate pathways, herein we established a robust nonlinear targeted switch with tunable active Co x sites integrated into Pd metallene, which involves Co 1 /Pd single-atom alloy (favoring CO) and Co 2 /Pd diatomic alloy (favoring formate). Transitioning from Co 1 /Pd to Co 2 /Pd atomic alloy bimetallenes resulted in a nonlinear, high-contrast flip in selectivity, surpassing 94 % for CO and formate productions in both H-cell and flow cell. Furthermore, the superior selectivity and current efficiency for CO (>80 %) and formate (>88 %) were consistently maintained at −150 mA cm −2 over continuous 200 h. Theoretical simulations and in situ spectroscopy analyses unveiled that appropriate adjacent metal site combinations (Pd−Pd, Pd−Co and Co−Co) lead to tunable d z 2 band center and a nonlinear shift in preferred adsorption configurations of intermediates, dictating the C 1 pathways. Our finding reveals a desired switch in C 1 selectivity and robust stability within Co x /Pd system, providing a new perspective for fine-tuning energy conversion processes through specific topological assembly.}, archive = {J_ANGEW}, author = {Jiajing Pei and Can Li and Guikai Zhang and Jiangwen Liao and Yue Yu and Ruqi Wang and Ping Wang and Ang Li and Pengfei An and Shengqi Chu and Juncai Dong}, doi = {10.1002/anie.202414163}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414163}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Establishing a robust nonlinear targeted switch for c1 electroproduction in atomic alloy Cox/Pd bimetallenes}, volume = {64}, year = {2025}, }
• (2025). Development of the esterase PestE for amide bond synthesis under aqueous conditions: Enzyme cascades for converting waste PET into tamibarotene. ANGEW, 64(2), e202414162. (www)

  @article{ , abstract = {A growing number of hydrolase enzymes show promiscuous acyltransferase activity, even under aqueous conditions. Here we report, for the first time, the ability of Pyrobaculum calidifontis VA1 esterase (PestE) to catalyse the formation of a wide range of amides in buffer, where the acyl donor forms a significant structural component in the amide product. The reactions occur under mild conditions and can achieve conversions up to 97 % in 6 h for formation of N-benzylfuranamide as the model reaction. We demonstrate PestE's potential in enzyme cascades to make amides from waste PET plastic and the conversion of the terephthalic acid product to tamibarotene, a drug with activity against acute leukemia. Rational mutagenesis led to identification of PestE variants F33L F289A and F33L. F33L F289A increased conversion of N -benzylfuranamide by 1.2-fold, and F33L gave a 4-fold increase in conversion to tamibarotene.}, archive = {J_ANGEW}, author = {Ellie Goulding and Lucy C. Ward and Faye E. Allan and Drew Dittman and Jesus E. Salcedo-Sora and Andrew J. Carnell}, doi = {10.1002/anie.202414162}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development of the esterase PestE for amide bond synthesis under aqueous conditions: Enzyme cascades for converting waste PET into tamibarotene}, volume = {64}, year = {2025}, }
• (2025). C60 fullerene-induced reduction of metal ions: Synthesis of c60-metal cluster heterostructures with high electrocatalytic hydrogen-evolution performance. ANGEW, 64(2), e202414149. (www)

  @article{ , abstract = {Metal clusters, due to their small dimensions, contain a high proportion of surface atoms, thus possessing a significantly improved catalytic activity compared with their bulk counterparts and nanoparticles. Defective and modified carbon supports are effective in stabilizing metal clusters, however, the synthesis of isolated metal clusters still requires multiple steps and harsh conditions. Herein, we develop a C 60 fullerene-driven spontaneous metal deposition process, where C 60 serves as both a reductant and an anchor, to achieve uniform metal (Rh, Ir, Pt, Pd, Au and Ru) clusters without the need for any defects or functional groups on C 60 . Density functional theory calculations reveal that C 60 possesses multiple strong metal adsorption sites, which favors stable and uniform deposition of metal atoms. In addition, owing to the electron-withdrawing properties of C 60 , the electronic structures of metal clusters are effectively regulated, not only optimizing the adsorption behavior of reaction intermediates but also accelerating the kinetics of hydrogen evolution reaction. The synthesized Ru/C 60 -300 exhibits remarkable performance for hydrogen evolution in an alkaline condition. This study demonstrates a facile and efficient method for synthesizing effective fullerene-supported metal cluster catalysts without any pretreatment and additional reducing agent.}, archive = {J_ANGEW}, author = {Wenhao Yang and Qi Huang and Yingying Yan and Yaozhou Li and Tingting Xu and Ao Yu and Yihang Zhao and Ping Peng and Ying Wang and Luis Echegoyen and Fang-Fang Li}, doi = {10.1002/anie.202414149}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414149}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C60 fullerene-induced reduction of metal ions: Synthesis of c60-metal cluster heterostructures with high electrocatalytic hydrogen-evolution performance}, volume = {64}, year = {2025}, }
• (2025). Unraveling the role of electron-withdrawing molecules for highly efficient and stable perovskite photovoltaics. ANGEW, 64(2), e202414128. (www)

  @article{ , abstract = {Electron-withdrawing molecules (EWMs) have exhibited remarkable efficacy in boosting the performance of perovskite solar cells (PSCs). However, the underneath mechanisms governing their positive attributes remain inadequately understood. Herein, we conducted a comprehensive study on EWMs by comparing 2,2′-(2,5-cyclohexadiene-1,4-diylidene) bismalononitrile (TCNQ) and (2,3,5,6-tetrafluoro-2,5-cyclohexadiene-1,4-diylidene) dimalononitrile (F4TCNQ) employed at the perovskite/hole transport layer (HTL) interfaces. Our findings reveal that EWMs simultaneously enhance chemical passivation, interface dipole effect, and chemically binding of the perovskite to the HTL. Notably, F4TCNQ, with its superior electron-withdrawing properties, demonstrates a more pronounced impact. Consequently, PCSs modified with F4TCNQ achieved an impressive power conversion efficiency (PCE) of 25.21 %, while demonstrating excellent long-term stability. Moreover, the PCE of a larger-area perovskite module (14.0 cm 2 ) based on F4TCNQ reached 21.41 %. This work illuminates the multifaceted mechanisms of EWMs at the interfaces in PSCs, delivering pivotal insights that pave the way for the sophisticated design and strategic application of EWMs, thereby propelling the advancement of perovskite photovoltaic technology.}, archive = {J_ANGEW}, author = {Xiaoqing Jiang and Kaiwen Dong and Pingping Li and Likai Zheng and Bingqian Zhang and Yanfeng Yin and Guangyue Yang and Linqin Wang and Minhuan Wang and Suying Li and Lina Zhu and Shiyuan Niu and Shitao Yu and Shiwei Liu and Wenming Tian and Xin Guo and Mingyang Wei and Shaik M. Zakeeruddin and Licheng Sun and Shuping Pang and Michael Grätzel}, doi = {10.1002/anie.202414128}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414128}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unraveling the role of electron-withdrawing molecules for highly efficient and stable perovskite photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Coupling manipulation of interfacial chemistry and coordination structure in vanadium oxides enables rapid magnesium ion diffusion kinetics. ANGEW, 64(2), e202414119. (www)

  @article{ , abstract = {Rechargeable magnesium batteries (RMBs) are a highly promising energy storage system due to their high volumetric capacity and intrinsic safety. However, the practical development of RMBs is hindered by the sluggish Mg 2+ diffusion kinetics, including at the cathode-electrolyte interface (CEI) and within the cathode bulk. Herein, we propose an efficient strategy to manipulate the interfacial chemistry and coordination structure in oligolayered V 2 O 5 (L−V 2 O 5 ) for achieving rapid Mg 2+ diffusion kinetics. In terms of the interfacial chemistry, the specific exposed crystal planes in L−V 2 O 5 possess strong electron donating ability, which helps to promote the degradation dynamics of C−F/C−S bonds in the electrolyte, thereby establishing the inorganic-organic interlocking CEI layer for rapid Mg 2+ diffusion. In terms of the coordination structure, the straightened V−O structure in L−V 2 O 5 provides efficient ions diffusion path for accelerating Mg 2+ diffusion in the cathode. As a result, the L−V 2 O 5 delivers a high reversible capacity (355.3 mA h g −1 at 0.1 A g −1 ) and an excellent rate capability (161 mAh g −1 at 1 A g −1 ). Impressively, the interdigital micro-RMBs is firstly assembled, exhibiting excellent flexibility and practicability. This work gives deeper insights into the interface and interior ions diffusion for developing high-kinetics RMBs.}, archive = {J_ANGEW}, author = {Weixiao Wang and Wenwen Wang and Fangyu Xiong and Jiashen Meng and Jinsong Wu and Wei Yang and Juncai Long and Jinghui Chen and Jiajun Chen and Qinyou An}, doi = {10.1002/anie.202414119}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414119}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coupling manipulation of interfacial chemistry and coordination structure in vanadium oxides enables rapid magnesium ion diffusion kinetics}, volume = {64}, year = {2025}, }
• (2025). Cyclic multi-site chelation for efficient and stable inverted perovskite solar cells. ANGEW, 64(2), e202414118. (www)

  @article{ , abstract = {Trap-assisted non-radiative recombination losses and moisture-induced degradation significantly impede the development of highly efficient and stable inverted (p–i–n) perovskite solar cells (PSCs), which require high-quality perovskite bulk. In this research, we mitigate these challenges by integrating thermally stable perovskite layers with Lewis base covalent organic frameworks (COFs). The ordered pore structure and surface binding groups of COFs facilitate cyclic, multi-site chelation with undercoordinated lead ions, enhancing the perovskite quality across both its bulk and grain boundaries. This process not only reduces defects but also promotes improved energy alignment through n -type doping at the surface. The inclusion of COF dopants in p–i–n devices achieves power conversion efficiencies (PCEs) of 25.64 % (certified 24.94 %) for a 0.0748-cm 2 device and 23.49 % for a 1-cm 2 device. Remarkably, these devices retain 81 % of their initial PCE after 978 hours of accelerated aging at 85°C, demonstrating remarkable durability. Additionally, COF-doped devices demonstrate excellent stability under illumination and in moist conditions, even without encapsulation.}, archive = {J_ANGEW}, author = {Jiandong He and Shuai Yang and Chao Luo and Fengzhu Li and Xin Jiang and Zhe Liu and Yishun Feng and Ruihan Wu and Zhong-Rui Lan and Mingquan Tao and Guosheng Niu and Kaiyi Yang and Yu Yuan and Yili Wang and Xiao Deng and Yongjie Chen and Siyuan Zeng and Yao Zhao and Fuyi Wang and Yu-Wu Zhong and Weifeng Zhang and Qing Zhao and Feng Liu and Gui Yu and Jizheng Wang}, doi = {10.1002/anie.202414118}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414118}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cyclic multi-site chelation for efficient and stable inverted perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Bidentate coordination enables anions-regulated solvation structure for advanced aqueous zinc metal batteries. ANGEW, 64(2), e202414117. (www)

  @article{ , abstract = {Rechargeable aqueous Zn metal batteries (AZMBs) are attractive for stationary energy storage due to their low cost and high safety. However, their practical application is hindered by the excessive use of zinc anodes and poor high-temperature performance, caused by severe side reactions and dendritic growth issues. Here, an electrolyte design strategy is reported based on bidentate coordination of Zn 2+ and solvent to tailor the solvation structure. The triethylene glycol (TEG) co-solvent with two-oxygen coordination sites is demonstrated to facilitate the formation of an anions-involved solvation shell, greatly reducing the activity of coordinated H 2 O molecules. The sequential reduction of OTF − anions and TEG leads to the formation of an organic–inorganic bilayer SEI (hydrophobic organic layer and high ion conductivity inorganic layer), protecting Zn anodes from side reactions and dendrite growth, thus ensuring an unprecedented Zn reversibility (99.95 % over 5000 cycles at 0.5 mA cm −2 ). More importantly, the full cells of Zn||V 2 O 5 exhibit a record-high cumulative capacity (2552 mAh cm −2 ) under a lean electrolyte condition (E/C ratio=15 μl mAh −1 ), a limited Zn supply (N/P ratio=1.9) and a high areal capacity (3.0 mAh cm −2 ).}, archive = {J_ANGEW}, author = {Dongdong Wang and Rui Li and Jingjing Dong and Zhongchao Bai and Nana Wang and Shi Xue Dou and Jian Yang}, doi = {10.1002/anie.202414117}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414117}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bidentate coordination enables anions-regulated solvation structure for advanced aqueous zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Single exposed zn (0002) plane and sustainable zn-oriented growth achieving highly reversible zinc metal batteries. ANGEW, 64(2), e202414116. (www)

  @article{ , abstract = {To prevent dendrite growth and hydrogen evolution reaction, directional epitaxial growth of Zn 2+ ions on Zn anode, especially along the lowest-surface-energy Zn (0002) plane, is pursued for highly reversible zinc metal batteries (ZMBs). However, designing single Zn (0002) exposed anodes for sustained uniaxial crystalline orientation of Zn electroplating faces challenges. Herein, we propose an anode engineering that utilizes a low lattice mismatch substrate and ordered Zn 2+ migration channels to modify Zn anodes with single (0002) surface exposure and sustainable Zn-oriented growth, yielding highly reversible ZMBs. A vapor-deposited metal–organic framework Cu 3 (C 6 O 6 ) 2 film on brass foil shows low lattice mismatch (4.24 %) with electrodeposited Zn anodes, enabling the exposure of a single (0002) plane. Furthermore, the low desolvation energy (−1.36 eV) between solvated Zn 2+ ions and the ordered porous Cu 3 (C 6 O 6 ) 2 film guides sustainable Zn-oriented nucleation along the Zn (0002) surface. Consequently, the Zn||Zn cells with brass-Cu 3 (C 6 O 6 ) 2 substrate shows a high average Coulombic efficiency of 99.55 % after 4,000 cycles at 10 mA cm −2 . This work provides a new window to design highly reversible Zn metal anode with a single-exposed Zn (0002) plane and sustainable oriented growth for emerging ZMBs.}, archive = {J_ANGEW}, author = {Da Zhang and Ziyang Song and Ling Miao and Yaokang Lv and Hui Duan and Mingfang Li and Lihua Gan and Mingxian Liu}, doi = {10.1002/anie.202414116}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414116}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single exposed zn (0002) plane and sustainable zn-oriented growth achieving highly reversible zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Metallo-supramolecular helicates as surface-enhanced raman scattering (SERS) substrates with high tailorability. ANGEW, 64(2), e202414089. (www)

  @article{ , abstract = {The exploration of novel functionalized supramolecular coordination complexes (SCCs) can enable new applications in domains that include purification and sensing. In this study, employing a coordination-driven self-assembly strategy, we designed and prepared a series of benzochalcogenodiazole-based metallohelicates as high-efficiency charge-transfer surface-enhanced Raman scattering (SERS) substrates, expanding the range of applications for these metallohelicates. Through structural modifications, including the substitution of single heteroatoms on ligands, replacement of coordinating metals, and alteration of ligand framework linkages, the Raman performance of these metallohelicates as substrates were systematically optimized. Notably, the SERS enhancement factors (EFs) of the metallohelicate-based SERS substrates were significantly enhanced to levels as high as 1.03×10 7 , which rivals the EFs of noble metals devoid of “hot spots”. Additionally, the underlying Raman enhancement mechanisms of these metallohelicates have been investigated through a combination of control experiments and theoretical calculations. This study not only demonstrates the utility of metallohelicates as SERS substrates but also offers insights and materials for the development of high-efficiency new charge-transfer SERS substrates.}, archive = {J_ANGEW}, author = {Bo Song and Zhonghui Zhang and Weitao Dou and Xiaoli Zhao and Yanfei Niu and Chen Wang and Chunchun Li and Jonathan R. Nitschke and Yang Tian and Hai-Bo Yang and Lin Xu}, doi = {10.1002/anie.202414089}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414089}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Metallo-supramolecular helicates as surface-enhanced raman scattering (SERS) substrates with high tailorability}, volume = {64}, year = {2025}, }
• (2025). Catalytic edges in one-dimensional covalent organic frameworks for the oxygen reduction reaction. ANGEW, 64(2), e202414075. (www)

  @article{ , abstract = {Metal-free covalent organic frameworks (COFs) are employed in oxygen reduction reactions (ORR) because of their diverse structural units and controllable catalytic sites, and the edge sites have high catalytic activity than the basal sites. However, it is still challenge to modulate the edge sites in COFs, because the extended frameworks in two- or three-dimensional topologies resulted in limited edge parts. In this study, we have demonstrated the edge site modulation engineering based on one dimensional (1D) COFs to catalyze the ORR, which featured distinct edge groups-carbonyl, diaminopyrazine, phenylimidazole, and benzaldehyde imidazole units. The synthesized COFs have same ordered frameworks, similar pore structure, but had different electronic states of the carbons along the edge sites, which results in tailored catalytic properties. Notably, the COF functionalized with a phenylimidazole edge group exhibited superior catalytic performance compared to the other synthesized COFs. And the theoretical calculation further revealed the different edge sites had tunable binding ability of the intermediates OOH*, which contributed modulated activity. Our findings introduce a novel way for designing COFs optimized for ORR applications through molecular level control of edge sites.}, archive = {J_ANGEW}, author = {Yumeng Chang and Chao Lin and Haifeng Wang and Xiaotong Wu and Luyao Zou and Jixin Shi and Qi Xiao and Qing Xu and Xiaopeng Li and Wei Luo}, doi = {10.1002/anie.202414075}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414075}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic edges in one-dimensional covalent organic frameworks for the oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Effective enrichment of free radicals through nanoconfinement boosts electrochemiluminescence of carbon dots derived from luminol. ANGEW, 64(2), e202414073. (www)

  @article{ , abstract = {Local enrichment of free radicals at the electrode interface may open new opportunities for the development of electrochemiluminescence (ECL) applications. The sensing platform was constructed by assembling ECL-emitting luminol derived carbon dots (Lu CDs) onto the heterojunction Tungsten disulfide/Covalent organic frameworks (WS 2 @COF) for the first time, establishing a nanoconfinement-reactor with significantly heightened ECL intensity and stability compared to the Lu CDs-H 2 O 2 system. This enhanced performance is credited to the COF domain‘s restricted pore environment, where WS 2 @COF exhibits a more negative adsorption energy for H 2 O 2 , effectively enriching H 2 O 2 in the catalytic edge sites of WS 2 . Furthermore, the internal electric field at the WS 2 and COF interface accelerates electron flow, boosting WS 2 ′s catalytic activity and achieving domain-limited catalytic enhancement of ECL. Self-designed DNA nanomachines combined with cascading molecular keypad locking mechanisms are integrated into the biosensors, effectively guaranteeing the accuracy of the sensing process while providing crucial safeguards for molecular diagnostics and information security applications. In essence, this innovative approach represents the first system to enhance local free radical concentrations by enriching co-reactants on the electrode surface through nanoconfinement catalysis, yielding heightened ECL intensity. The potential impact of this novel strategy and sensing mechanism on real-bioanalysis applications is promising.}, archive = {J_ANGEW}, author = {Yujie Han and Xiang Ren and Tingting Wu and Yan Lei Li and Hongmin Ma and Zhuangzhuang Ru and Yue Jia and Zhong Feng Gao and Yu Du and Dan Wu and Qin Wei}, doi = {10.1002/anie.202414073}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414073}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Effective enrichment of free radicals through nanoconfinement boosts electrochemiluminescence of carbon dots derived from luminol}, volume = {64}, year = {2025}, }
• (2025). Beyond single-cycle autonomous molecular machines: Light-powered shuttling in a multi-cycle reaction network. ANGEW, 64(2), e202414072. (www)

  @article{ , abstract = {Biomolecular machines autonomously convert energy into functions, driving systems away from thermodynamic equilibrium. This energy conversion is achieved by leveraging complex, kinetically asymmetric chemical reaction networks that are challenging to characterize precisely. In contrast, all known synthetic molecular systems in which kinetic asymmetry has been quantified are well described by simple single-cycle networks. Here, we report on a unique light-driven [2]rotaxane that enables the autonomous operation of a synthetic molecular machine with a multi-cycle chemical reaction network. Unlike all prior systems, the present one exploits a photoactive macrocycle, which features a different photoreactivity depending on the binding sites at which it resides. Furthermore, E to Z isomerization reverses the relative affinity of the macrocycle for two binding sites on the axle, resulting in a multi-cycle network. Building on the most recent theoretical advancements, this work quantifies kinetic asymmetry in a multi-cycle network for the first time. Our findings represent the simplest rotaxane capable of autonomous shuttling developed so far and offer a general strategy to generate and quantify kinetic asymmetry beyond single-cycle systems.}, archive = {J_ANGEW}, author = {Zhiyao Yang and Xirui Wang and Emanuele Penocchio and Giulio Ragazzon and Xinnan Chen and Shuai Lu and Yidan Zhou and Kuirong Fu and Zejiang Liu and Yimin Cai and Xiujun Yu and Xiaopeng Li and Xiaowei Li and Wen Feng and Lihua Yuan}, doi = {10.1002/anie.202414072}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414072}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Beyond single-cycle autonomous molecular machines: Light-powered shuttling in a multi-cycle reaction network}, volume = {64}, year = {2025}, }
• (2025). ‘Invisible’ molecular dynamics revealed for a conformationally chiral π-stacked perylene bisimide foldamer. ANGEW, 64(2), e202414069. (www)

  @article{ , abstract = {Whilst energetic and kinetic aspects of folding processes are meanwhile well understood for natural biomacromolecules, the folding dynamics in so far studied artificial foldamer counterparts remain largely unexplored. This is due to the low energy barriers between their conformational isomers that make the dynamic processes undetectable with conventional methods such as UV/Vis absorption, fluorescence, and NMR spectroscopy, making such processes ‘invisible’. Here we present an asymmetric perylene bisimide dimer (bis-PBI 1 ) that possesses conformational chirality in its folded state. Owing to the large interconversion barrier (≥116 kJ mol −1 ), four stereoisomers could be separated and isolated. Since the interconversion between these stereoisomers requires the foldamer to first open and then to re-fold, the transformation of one stereoisomer into others allowed us to ‘visualize’ the dynamics of folding with time and determine its lifetimes and the energetic barriers associated with the folding process. Supported by quantum chemical calculations, we identified the open structure to be only a fleetingly metastable state of higher energy. Our experimental observation of the kinetics associated with the molecular dynamics in the PBI foldamer advances the fundamental understanding of folding in synthetic foldamers and paves the way for the design of smart functional materials.}, archive = {J_ANGEW}, author = {Ben Teichmann and Menyhárt Sárosi and Kazutaka Shoyama and M. A. Niyas and Rajeev K. Dubey and Frank Würthner}, doi = {10.1002/anie.202414069}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {‘Invisible’ molecular dynamics revealed for a conformationally chiral π-stacked perylene bisimide foldamer}, volume = {64}, year = {2025}, }
• (2025). Engineering of a multi-modular DNA nanodevice for spatioselective imaging and evaluation of NK cell-mediated cancer immunotherapy. ANGEW, 64(2), e202414064. (www)

  @article{ , abstract = {Granzyme A (GzmA) secreted by natural killer (NK) cells has garnered considerable interest as a biomarker to evaluate the efficacy of cancer immunotherapy. However, current methodologies to selectively monitor the spatial distribution of GzmA in cancer cells during NK cell-targeted therapy are extremely challenging, primarily due to the existence of diverse cell populations, the low levels of GzmA expression, and the limited availability of GzmA probes. Herein we develop a m ulti-modular, structurally- o rdered D NA nanodevice for e valuating NK cell-mediated cance r immu n otherapy (MODERN), that permits spatioselective imaging of GzmA in cancer cells through GzmA-induced apurinic/apyrimidinic endonuclease 1 (APE1) inactivation. The MODERN incorporates multiple functional modules, including an APE1-gated recognition module, a photo-activated amplification module, an aptamer-mediated tumor-target module, and a polycatenane DNA module, enabling improved sensitivity and specificity towards intracellular GzmA. The MODERN was activated (on) in cancer cells due to the overexpression of APE1, whereas it remained silent (off) in the NK-treated cancer cells owing to the GzmA-induced APE1 inactivation. Furthermore, we demonstrated that GzmA-induced APE1 inactivation blocks the cellular repair of target cells, resulting in efficient cell death. This MODERN that relies on the specific inactivation of APE1 by GzmA should be beneficial for evaluating the efficacy of cancer immunotherapy.}, archive = {J_ANGEW}, author = {Zhao-Peng Chen and Wei-Jia Zeng and Yan-Mei Lei and Wen-Bin Liang and Xia Yang and Ruo Yuan and Chaoyong Yang and Ying Zhuo}, doi = {10.1002/anie.202414064}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414064}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering of a multi-modular DNA nanodevice for spatioselective imaging and evaluation of NK cell-mediated cancer immunotherapy}, volume = {64}, year = {2025}, }
• (2025). L–Cysteine-catalysed hydration of activated alkynes. ANGEW, 64(2), e202414046. (www)

  @article{ , abstract = {Hydration reactions consist of the introduction of a molecule of water into a chemical compound and are particularly useful to transform alkynes into carbonyls, which are strategic intermediates in the synthesis of a plethora of compounds. Herein we demonstrate that L–cysteine can catalyse the hydration of activated alkynes in a very effective and fully regioselective manner to access important building blocks in synthetic chemistry such as β-ketosulfones, amides and esters, in aqueous media. The mild reaction conditions facilitated the integration with enzyme catalysis to access chiral β-hydroxy sulfones from the corresponding alkynes in a one-pot cascade process in good yields and excellent enantiomeric ratios. These findings pave the way towards establishing a general method for metal-free, cost-effective, and more sustainable alkyne hydration processes.}, archive = {J_ANGEW}, author = {Jorge González-Rodríguez and Sergio González-Granda and Iván Lavandera and Vicente Gotor-Fernández and Juan Mangas-Sánchez}, doi = {10.1002/anie.202414046}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414046}, shortjournal = {Angew. Chem. Int. Edit.}, title = {L–Cysteine-catalysed hydration of activated alkynes}, volume = {64}, year = {2025}, }
• (2025). Full-color emissive zirconium-organic frameworks constructed via in situ “One-pot” single-site modification for tryptophan detection and energy transfer. ANGEW, 64(2), e202414026. (www)

  @article{ , abstract = {Organic linker-based luminescent metal–organic frameworks (LMOFs) have received extensive studies due to the unlimited species of emissive organic linkers and tunable structure of MOFs. However, the multiple-step organic synthesis is always a great challenge for the development of LMOFs. As an alternative strategy, in situ “one-pot” strategy, in which the generation of emissive organic linkers and sequential construction of LMOFs happen in one reaction condition, can avoid time-consuming pre-synthesis of organic linkers. In the present work, we demonstrate the successful utilization of in situ “one-pot” strategy to construct a series of LMOFs via the single-site modification between the reaction of aldehydes and o -phenylenediamine-based tetratopic carboxylic acid. The resultant MOFs possess csq topology with emission covering blue to near-infrared. The nanosized LMOFs exhibit excellent sensitivity and selectivity for tryptophan detection. In addition, two component-based LMOFs can also be prepared via the in situ “one-pot” strategy and used to study energy transfer. This work not only reports the construction of LMOFs with full-color emissions, which can be utilized for various applications, but also indicates that in situ “one-pot” strategy indeed is a useful and powerful method to complement the traditional MOFs construction method for preparing porous materials with tunable functionalities and properties.}, archive = {J_ANGEW}, author = {Pu-Hao Fang and Lu-Lu Qu and Zhen-Sha Ma and Chao-Qin Han and Zhendong Li and Lei Wang and Kang Zhou and Jingbai Li and Xiao-Yuan Liu}, doi = {10.1002/anie.202414026}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414026}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Full-color emissive zirconium-organic frameworks constructed via in situ “One-pot” single-site modification for tryptophan detection and energy transfer}, volume = {64}, year = {2025}, }
• (2025). Synthesis and solvent free DLP 3D printing of degradable Poly(Allyl glycidyl ether succinate). ANGEW, 64(2), e202414016. (www)

  @article{ , abstract = {Digital light processing (DLP) printing forms solid constructs from fluidic resins by photochemically crosslinking polymeric resins with reactive functional groups. DLP is used widely due to its efficient, high-resolution printing, but its use and translational potential has been limited in some applications as state-of-the-art resins experience unpredictable and anisotropic part shrinkage due to the use of solvent needed to reduce resin viscosity and layer dependent crosslinking. Herein, poly(allyl glycidyl ether succinate) (PAGES), a low viscosity, degradable polyester, was synthesized by ring opening copolymerization and used in combination with degradable thiol crosslinkers to afford a solvent free resin that can be utilized in DLP printing. Varying resin formulations of PAGES polymer are shown to decrease part shrinkage from 14 % to 0.3 %. Photochemically printed parts fabricated from PAGES possess tensile moduli between 0.43 and 6.18 MPa and degradation profiles are shown to vary between 12 and 40 days under accelerated conditions based on degree of polymerization and crosslink ratio.}, archive = {J_ANGEW}, author = {Maddison I. Segal and Alexander J. Bahnick and Nicola G. Judge and Matthew L. Becker}, doi = {10.1002/anie.202414016}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202414016}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis and solvent free DLP 3D printing of degradable Poly(Allyl glycidyl ether succinate)}, volume = {64}, year = {2025}, }
• (2025). Dibenzoquinone cyclopentadithiophene diradicaloids show optical transitions of different spin states and anomalous near-infrared emission. ANGEW, 64(2), e202413988. (www)

  @article{ , abstract = {We have prepared a series of bis(semiquinone) compounds with dithiophene bridges of different length that evolve from closed-shell (smaller compound) to full diradical (longer compound) for which the narrow singlet-triplet energy gap allows the triplet population at 298 K. The medium size system has a variety of photonic properties with absorptions and emission in the optical near-infrared region mediated by a unique case of anti-Kasha emission. A whole set of optical absorption/emission and vibrational steady state spectroscopies as well as picosecond transient absorption spectroscopy, all complemented with spectroelectrochemistry and theoretical calculations, is presented.}, archive = {J_ANGEW}, author = {María Privado and Sergio Moles Quintero and Myriam Barrejón and Pilar de La Cruz and Janaarthana Babu P. M. and David Casanova and Fernando Langa and Juan Casado}, doi = {10.1002/anie.202413988}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413988}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dibenzoquinone cyclopentadithiophene diradicaloids show optical transitions of different spin states and anomalous near-infrared emission}, volume = {64}, year = {2025}, }
• (2025). Solution-processing induced H-aggregate of perylene-diimide zwitterion exhibiting compact molecular stacking toward efficient cathode modification in organic solar cells. ANGEW, 64(2), e202413986. (www)

  @article{ , abstract = {High-performance organic cathode interlayers (CILs) play a crucial role in the advance of organic solar cells (OSCs). However, organic CILs have exhibited inferior performances to their inorganic counterparts over a long time, due to the inherent shortcoming of poor charge transporting capability. Here, we designed and synthesized a perylene-diimide (PDI) zwitterion PDI-B as high-performance organic CIL for OSCs. We revealed that an obvious H-aggregate of PDI-B was formed during the solution processing, thereby significantly enhancing the charge transporting capability of the CIL. Compared to the classic PDINN, the π–π stacking distance of PDI-B was reduced from 4.2 Å to 3.9 Å, which further facilitated the charge transport. Consequently, PDI-B showed a high conductivity of 1.81×10 −3 S/m; this is comparable to that of inorganic CILs. The binary OSC showed an elevated PCE of 19.23 %, which is among the highest PCE values for binary OSCs. Benefitting from improved solvent resistance and good compatibility with large-area processing method of PDI-B, the photovoltaic performances of inverted and 1-cm 2 OSC were significantly improved. The results from this work provide a new approach of optimizing the condensed structure of PDI film to boost the charge conductivity, opening an avenue to develop high-performance PDI-based CILs.}, archive = {J_ANGEW}, author = {Zhe Li and Yanhe Xiang and Jiayu Li and Luxin Feng and Ming Zhang and Zhiguo Zhang and Shouke Yan and Bowei Xu}, doi = {10.1002/anie.202413986}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413986}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solution-processing induced H-aggregate of perylene-diimide zwitterion exhibiting compact molecular stacking toward efficient cathode modification in organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Engineering π-electron bridge enables low-potential 2D redox polymer anodes for high-voltage aqueous all-organic batteries. ANGEW, 64(2), e202413971. (www)

  @article{ , abstract = {Aqueous all-organic batteries (AAOBs) have emerged as a hot topic but their development was plagued by limited choices of anode materials, generally facing an intractable trade-off between low potential and high stability. Here, we propose a novel π-electron bridge engineering strategy to explore a class of 2D dioxin-bridged redox covalent organic polymer (RCOP) as trade-off-breaking anodes for high-voltage AAOBs. By establishing a tunable RCOP platform, we perform theoretical study to scrutinize how bridge units between active sites affect the electrode potential and redox activity for the first time. We discover that compared to common pyrazine bridge, the weakened conjugation and strong electron donor character of the proposed dioxin bridge can induce elevated LUMO level and enriched π-electron populations in active sites, heralding a low electrode potential and enhanced redox activity. Besides, the nonaromaticity-induced molecular flexibility of dioxin bridge mitigates intermolecular stacking for sufficient active sites exposure. To experimentally corroborate this, a new dioxin-bridged 2D RCOP (D-HATN) and its pyrazine-bridged analogue (P-HATN) are synthesized for proof-of-concept demonstration. D-HATN displays excellent compatibility with Na + /Zn 2+ /NH 4 + /H 3 O + and obviously lower redox potentials in various dilute electrolytes compared to P-HATN and most reported organic anodes, while featuring rapid Grotthuss-type proton conduction and unprecedented durability in acid – 91.8 % capacity retention after 20000 cycles. Thus, the D-HATN-involved all-organic proton battery delivers an average output voltage of 0.75 V, which can be further elevated to 1.63 V with alkaline-acidic hybrid electrolyte design, affording markedly-increased specific energy.}, archive = {J_ANGEW}, author = {Linfeng Zhong and Cong Liu and Yang Zhang and Jing Li and Fan Yang and Zishou Zhang and Dingshan Yu}, doi = {10.1002/anie.202413971}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413971}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering π-electron bridge enables low-potential 2D redox polymer anodes for high-voltage aqueous all-organic batteries}, volume = {64}, year = {2025}, }
• (2025). Design of ultra-narrow bandgap polymer acceptors for high-sensitivity flexible all-polymer short-wavelength infrared photodetectors. ANGEW, 64(2), e202413965. (www)

  @article{ , abstract = {All-polymer photodetectors possess unique mechanical flexibility and are ideally suitable for the application in next-generation flexible, wearable short-wavelength infrared (SWIR, 1000–2700 nm) photodetectors. However, all-polymer photodetectors commonly suffer from low sensitivity, high noise, and low photoresponse speed in the SWIR region, which significantly diminish their application potential in wearable electronics. Herein, two polymer acceptors with absorption beyond 1000 nm, namely P4TOC-DCBT and P4TOC-DCBSe, were designed and synthesized. The two polymers possess rigid structure and good conformational stability, which is beneficial for reducing energetic disorder and suppressing dark current. Owing to the efficient charge generation and ultralow noise current, the P4TOC-DCBT-based all-polymer photodetector achieved a specific detectivity ( ) of over 10 12 Jones from 650 (visible) to 1070 nm (SWIR) under zero bias, with a response time of 1.36 μs. These are the best results for reported all-polymer SWIR photodetectors in photovoltaic mode. More significantly, the all-polymer blend films exhibit good mechanical durability, and hence the P4TOC-DCBT-based flexible all-polymer photodetectors show a small performance attenuation (<4 %) after 2000 cycles of bending to a 3 mm radius. The all-polymer flexible SWIR organic photodetectors are successfully applied in pulse signal detection, optical communication and image capture.}, archive = {J_ANGEW}, author = {Xiaofeng Chen and Yu Zhu and Yan Xu and Mei Rao and Pengfei Pang and Bo Zhang and Chenhui Xu and Wang Ni and Guanghui Li and Jishan Wu and Miaomiao Li and Yongsheng Chen and Yanhou Geng}, doi = {10.1002/anie.202413965}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413965}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Design of ultra-narrow bandgap polymer acceptors for high-sensitivity flexible all-polymer short-wavelength infrared photodetectors}, volume = {64}, year = {2025}, }
• (2025). C1-4 alkylation of aryl bromides with light alkanes enabled by metallaphotocatalysis in flow. ANGEW, 64(2), e202413846. (www)

  @article{ , abstract = {The homologous series of gaseous C1-4 alkanes represents one of the most abundant sources of short alkyl fragments. However, their application in synthetic organic chemistry is exceedingly rare due to the challenging C−H bond cleavage, which typically demands high temperatures and pressures, thereby limiting their utility in the construction of complex organic molecules. In particular, the formation of C(sp 2 )−C(sp 3 ) bonds is crucial for constructing biologically active molecules, including pharmaceuticals and agrochemicals. In this study, we present the previously elusive coupling between gaseous alkanes and (hetero)aryl bromides, achieved through a combination of Hydrogen Atom Transfer (HAT) photocatalysis and nickel-catalyzed cross coupling at room temperature. Utilizing flow technology allowed us to conduct this novel coupling reaction with reduced reaction times and in a scalable fashion, rendering it practical for widespread adoption in both academia and industry. Density Functional Theory (DFT) calculations unveiled that the oxidative addition constitutes the rate-determining step, with the activation energy barrier increasing with smaller alkyl radicals. Furthermore, radical isomerization observed in propane and butane analogues could be attributed to the electronic properties of the bromoarene coupling partner, highlighting the crucial role of oxidative addition in the observed selectivity of this transformation.}, archive = {J_ANGEW}, author = {Antonio Pulcinella and Prakash Chandra Tiwari and Alberto Luridiana and Ken Yamazaki and Daniele Mazzarella and Akshay K. Sadhoe and Antonella Ilenia Alfano and Eveline H. Tiekink and Trevor A. Hamlin and Timothy Noël}, doi = {10.1002/anie.202413846}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413846}, shortjournal = {Angew. Chem. Int. Edit.}, title = {C1-4 alkylation of aryl bromides with light alkanes enabled by metallaphotocatalysis in flow}, volume = {64}, year = {2025}, }
• (2025). Copper(I)-catalyzed asymmetric 1,4-hydroarsination of α,β-unsaturated compounds. ANGEW, 64(2), e202413834. (www)

  @article{ , abstract = {Herein, a copper(I)-catalyzed asymmetric 1,4-hydroarsination of β-substituted α,β-unsaturated esters is achieved in moderate to excellent yields with high to excellent enantioselectivity, based on the proposed nucleophilic [Cu]−AsPh 2 species. As for α-substituted α,β-unsaturated esters, a 1,4-hydroarsination/enantioselective protonation event occurs smoothly in satisfying results. Furthermore, β-substituted α,β-unsaturated ketone, α,β-unsaturated amide, and α,β-unsaturated phosphine sulfide are well applied in the present catalytic system. Finally, some control experiments show that HAsPh 2 is activated through coordination with the copper(I) catalyst and HAsPh 2 exhibits inferior soft Lewis basicity to HPPh 2 in the presence of a copper(I)-bisphosphine complex.}, archive = {J_ANGEW}, author = {Jun-Zhao Xiao and Zhen-Xi Cai and Zhi-Zhou Pan and Ye Wang and Nan Jiang and Liang Yin}, doi = {10.1002/anie.202413834}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413834}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Copper(I)-catalyzed asymmetric 1,4-hydroarsination of α,β-unsaturated compounds}, volume = {64}, year = {2025}, }
• (2025). A double-walled noncovalent carbon nanotube by columnar packing of nanotube fragments. ANGEW, 64(2), e202413828. (www)

  @article{ , abstract = {Herein, we report the synthesis of double-walled noncovalent carbon nanotubes (CNTs) through host–guest complexation of nanotube fragments and tube-forming crystal engineering. As the smallest fragment of double-walled CNTs, a host–guest complex of perfluorocycloparaphenylene (PFCPP) and carbon nanobelt (CNB) was synthesized by mixing them in solvents. The immediate complexation of the PF[12]CPP⸧(6,6)CNB complex with a remarkably high association constant ( K a ) of 2×10 5 L/mol was observed. Time-dependent 1 H NMR and thermogravimetry measurements revealed that the stability of (6,6)CNB was significantly improved by encapsulation. X-ray crystallography confirmed the robust belt-in-ring structure of this complex. As indicated by the short distance between PF[12]CPP and (6,6)CNB (2.8 Å), intermolecular orbital interactions exist between the belt and the ring, which were further supported by theoretical calculation and phosphorescence quenching experiments. While the PF[12]CPP⸧(6,6)CNB complex adopts various crystal packing structures, chloroform was discovered to be a magic “glue” solvent inducing one-dimensional alignment of the PF[12]CPP⸧(6,6)CNB complex to build an unprecedented double-walled noncovalent CNT structure.}, archive = {J_ANGEW}, author = {Daiki Imoto and Hiroki Shudo and Akiko Yagi and Kenichiro Itami}, doi = {10.1002/anie.202413828}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413828}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A double-walled noncovalent carbon nanotube by columnar packing of nanotube fragments}, volume = {64}, year = {2025}, }
• (2025). Unusual cross-conjugation in cyclic dipeptide-based building blocks for Donor–Acceptor semiconducting conjugated polymers. ANGEW, 64(2), e202413782. (www)

  @article{ , abstract = {Cross conjugation, though prevalent in many organic compounds, is typically considered less effective for electron delocalization compared to linear conjugation. Consequently, it is rarely used as the backbone structure for semiconducting conjugated polymers. In this study, we designed and synthesized a novel building block, TIDP , which features a central cyclic dipeptide with cross conjugation characteristics. Strong intramolecular hydrogen bonding interactions confer TIDP with a highly rigid and coplanar conformation. Importantly, theoretical calculations reveal that π electrons are well delocalized across the entire structure, despite its low aromaticity. Conjugated polymers incorporating TIDP exhibit high charge carrier mobilities, demonstrating the effective π electrons delocalization of this innovative building block. Our findings show that with rational design, cross conjugation can achieve effective π electrons delocalization, providing a valuable approach for developing high-performance conjugated polymers for organic electronic materials.}, archive = {J_ANGEW}, author = {Sijing Wang and Feng Ye and Jingyi Wang and Riqing Ding and Meishan Peng and Jia-Tong Li and Yidan Luan and Jiaqiang Liao and Zi-Hao Guo}, doi = {10.1002/anie.202413782}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413782}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unusual cross-conjugation in cyclic dipeptide-based building blocks for Donor–Acceptor semiconducting conjugated polymers}, volume = {64}, year = {2025}, }
• (2025). Bicyclo[2.1.1]hexanes via intramolecular formal (3+2)-cycloaddition. ANGEW, 64(2), e202413695. (www)

  @article{ , abstract = {We report a synthesis of bicyclo[2.1.1]hexanes via an intramolecular formal (3+2) cycloaddition of allylated cyclopropanes bearing a 4-nitrobenzimine substituent. Both activated and unactivated alkenes are tolerated in the transformation. The bicyclic imine products are prone to photo-induced ring opening, allowing for the epimerization of C5-stereogenic compounds.}, archive = {J_ANGEW}, author = {Alexander S. Harmata and Elene Tatunashvili and Abigail Chang and Tao Wang and Corey R. J. Stephenson}, doi = {10.1002/anie.202413695}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413695}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Bicyclo[2.1.1]hexanes via intramolecular formal (3+2)-cycloaddition}, volume = {64}, year = {2025}, }
• (2025). Enantioselective construction of oxindoles bearing a quaternary carbon via Ni−Al bimetal-catalyzed formyl C−H alkylation. ANGEW, 64(2), e202413652. (www)

  @article{ , abstract = {Enantioselective transition metal-catalyzed C−H alkylation emerges as one of the most atom- and step-economical routes to chiral quaternary carbons, while big challenges still remain with acyl C−H alkylations. Herein, we use a Ni−Al bimetallic catalyst to facilitate a highly regioselective and highly enantioselective C−H alkylation of formamides with alkenes, constructing various oxindoles bearing a chiral quaternary carbon in up to 94 % yield and up to 95 % ee.}, archive = {J_ANGEW}, author = {Haorui Wang and Jiang-Fei Li and Mengying Xu and Qi-Lin Zhou and Weiwei Xu and Mengchun Ye}, doi = {10.1002/anie.202413652}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413652}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enantioselective construction of oxindoles bearing a quaternary carbon via Ni−Al bimetal-catalyzed formyl C−H alkylation}, volume = {64}, year = {2025}, }
• (2025). Allosteric CDC37 inhibitor disrupts chaperone complex to block CDK4/6 maturation. ANGEW, 64(2), e202413618. (www)

  @article{ , abstract = {Cell division cycle 37 (CDC37) is a member of the molecular chaperone family and acts as a cochaperone of heat shock protein 90 (HSP90), which is overexpressed in many cancer types as a regulator of protein kinase maturation. In this process, CDC37 selectively recognizes and stabilizes protein kinases by forming a HSP90-CDC37-kinase chaperone complex. The protein-protein interactions (PPIs) of HSP90-CDC37 and CDC37-kinase complexes contribute to malignant tumors, as oncogenic kinases in malignant cells depend upon CDC37 expression. Thus, inhibiting CDC37 to disrupt HSP90-CDC37-kinase chaperone complex reveals as a promising way to achieve selective inhibition of oncogenic kinase maturation. Herein, we report a small-molecule CDC37 inhibitor called DDO-6079 that simultaneously inhibits HSP90-CDC37 and CDC37-CDK4/6 chaperone complex by binding to an allosteric site on CDC37. DDO-6079 selectively inhibited the maturation of multiple oncogenic kinases to escape heat shock response (HSR). Furthermore, DDO-6079 decreased the thermostability of CDK6, reversed the resistance of CDK6 to palbociclib (a successful CDK4/6 inhibitor) in colorectal cancer cells and exhibited efficacy in vivo. Together, the results revealed that DDO-6079 is a first-in-class small molecule CDC37 inhibitor that disrupts the HSP90-CDC37-kinase chaperone complex and provides a new way to block kinase maturation.}, archive = {J_ANGEW}, author = {Lixiao Zhang and Wei Liu and Zhen Zheng and Qiuyue Zhang and Yanyi He and Jinying Gu and Danni Wang and Huangliang Shu and Jia Yu and Jianfeng Liu and Xingyu Yin and Lianshan Zhang and Jian Zhang and Qidong You and Lei Wang}, doi = {10.1002/anie.202413618}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413618}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Allosteric CDC37 inhibitor disrupts chaperone complex to block CDK4/6 maturation}, volume = {64}, year = {2025}, }
• (2025). Engineering stable decomposition products on cathode surfaces to enable high voltage all-solid-state batteries. ANGEW, 64(2), e202413591. (www)

  @article{ , abstract = {Sulfide solid electrolytes such as Li 6 PS 5 Cl hold high promise for solid-state batteries due to their high ionic conductivity; however, their oxidation potential of ~2.5 V is not compatible with high voltage Ni-rich cathodes such as LiNi x Co y Mn 1−x−y O 2 (x≥0.8). Using guidance from density functional theory, we devise an effective, conformal, and thin coating on the cathode active material, which suppresses the oxidative decomposition of Li 6 PS 5 Cl as shown by experiment. The nanometric coating on nickel-rich NMC85 enabled capacity retention of 82 % after 200 cycles (2.8–4.3 V vs Li + /Li) using Li 6 PS 5 Cl as the solid electrolyte. In comparison, cells with an uncoated CAM only displayed 56 % capacity retention. The coated-NCM85 cells also demonstrate much better rate performance and higher capacity. The enhanced performance is due to the formation of a stable amorphous cathode-electrolyte interphase accruing from the decomposition products of the LiPO 2 F 2 precursor (as predicted by DFT), which protect the sulfide electrolyte from oxidation. The coating fabricated in this cost-effective process showed superior performance to state-of-the-art coatings such as LiNbO 3 . This work highlights the importance of rationally designing stable coating materials based on their potential decomposition products and confirms the suitability of a low-cost and conformal coating to enable sulfide electrolyte-based all-solid-state batteries.}, archive = {J_ANGEW}, author = {Lanting Qian and Yangyang Huang and Cameron Dean and Ivan Kochetkov and Baltej Singh and Linda Nazar}, doi = {10.1002/anie.202413591}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413591}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering stable decomposition products on cathode surfaces to enable high voltage all-solid-state batteries}, volume = {64}, year = {2025}, }
• (2025). Binary iron-manganese cocatalyst for simultaneous activation of C−C and C−O bonds to maximally utilize lignin for syngas generation over InGaN. ANGEW, 64(2), e202413528. (www)

  @article{ , abstract = {Solar-powered lignin reforming offers a carbon-neutral route for syngas production. This study explores a dual non-precious iron-manganese cocatalyst to simultaneously activate both C−C and C−O bonds for maximizing the utilization of various substituents of native lignin to yield syngas. The cocatalyst, integrated with InGaN nanowires on a Si wafer, affords a measurable syngas evolution rate of 42.4 mol g cat −1 h −1 from native lignin in distilled water with a high selectivity of 93 % and tunable H 2 /CO ratios under concentrated light, leading to a considerable light-to-fuel efficiency of 11.8 %. The high FeMn atom efficiency arising from the 1-dimensional nanostructure of InGaN enables the achievement of a high turnover frequency (TOF) of 220896 mol syngas per mol FeMn per hour. Combined experimental and theoretical investigations reveal that the synergetic iron-manganese cocatalyst supported by InGaN nanowires enables simultaneous activation of C−C and C−O bonds with comparable minimized dissociation energies, thus promising to maximally utilize different substituents of −OCH 3 , and −CH 2 CH 2 CH 3 in lignin for syngas production. Moreover, the dual Fe-Mn cocatalyst demonstrates a most energetically favorable route for the consecutive release of hydrogen from •CH 3 and •OH by the oxidative holes while inhibiting the reversion of hydrogen and hydroxyl into water.}, archive = {J_ANGEW}, author = {Tianqi Yu and Ying Zhao and Jingling Li and Yixin Li and Liang Qiu and Hu Pan and Muhammad Salman Nasir and Jun Song and Zhen Huang and Baowen Zhou}, doi = {10.1002/anie.202413528}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413528}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Binary iron-manganese cocatalyst for simultaneous activation of C−C and C−O bonds to maximally utilize lignin for syngas generation over InGaN}, volume = {64}, year = {2025}, }
• (2025). Intratumoral transforming boron nanosensitizers for amplified boron neutron capture therapy. ANGEW, 64(2), e202413232. (www)

  @article{ , abstract = {Boron neutron capture therapy (BNCT) is an advanced binary tumor-cell-selected heavy-particle radiotherapy used for treating invasive malignant tumors. However, its clinical applications have been impeded by the rapid metabolism and insufficient tumor-specific accumulation of boron agents. To tackle this issue, we develop a smart boron nanosensitizer (BATBN) capable of transforming its size in response to cancer biomarker for optimal balance between penetration and retention of boron-10 for BNCT. BATBN comprises an ultrasmall boron quantum dots (BQD) core (4 nm) conjugated with cell-penetrating peptides, which facilitates its cellular uptake and deep tumor penetration. In the tumor microenvironment, the tumor biomarker can specifically initiate a self-condensation reaction of BATBN, leading to the formation of larger-sized nanoaggregates. Due to such a specific intratumoral transformation, BATBN demonstrates a 2.4-fold increase in intratumoral boron concentration and a 5.0-fold increase in tumor retention time compared to the BQDs. Thus, the tumor volume of the BATBNs-treatment group is 2.7-fold smaller than that of BQDs in preclinical tumor models after 21 days of neutron irradiation treatment. This study presents a supramolecular strategy to endow BNCT agents with the biomarker-activated size interconversion, permitting precise and efficient BNCT for cancer treatment.}, archive = {J_ANGEW}, author = {Liping Li and Mixue Wang and Qian Zhao and Peirong Bai and Haotian Hao and Zizhu Zhang and Tong Liu and Yongzhen Yang and Kanyi Pu and Ruiping Zhang}, doi = {10.1002/anie.202413232}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413232}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intratumoral transforming boron nanosensitizers for amplified boron neutron capture therapy}, volume = {64}, year = {2025}, }
• (2025). On-site portable lithium detection in mining and recycling industries based on a DNAzyme fluorescent sensor. ANGEW, 64(2), e202413118. (www)

  @article{ , abstract = {The global demand for lithium has soared in recent years due to the wide use of lithium batteries. To meet this demand, we herein report developing novel on-site sample preparation methods for the extraction of Li + from relevant materials, including brine water, spodumene rock, as well as lithium-ion battery electrodes, and a DNAzyme-based fluorescent sensor for sensitive and robust detection of Li + in these samples down to 1.4 mM (10 ppm) using a portable fluorometer. The system can distinguish key threshold lithium levels that indicate economic value across several industries, including 200 ppm Li + for brine mining, 6 % Li 2 O or SC6 for rock mining, and Li + -specific aging in LIBs. The methods developed and demonstrated in this work will allow highly selective, on-site, portable detection of lithium in both environmental samples to identify new lithium resources and in battery electrodes to guide recycling strategies in order to meet the global demand for lithium.}, archive = {J_ANGEW}, author = {Zhenglin Yang and Annie Farrell and Shreestika Pradhan and Karen Huilin Zhang and Weijie Guo and Yuting Wu and Xiangli Shao and Aritra Roy and Elijah S. Garcia and Yi Lu}, doi = {10.1002/anie.202413118}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202413118}, shortjournal = {Angew. Chem. Int. Edit.}, title = {On-site portable lithium detection in mining and recycling industries based on a DNAzyme fluorescent sensor}, volume = {64}, year = {2025}, }
• (2025). Spatial and temporal visualization of polymorphic transformations in pharmaceutical tablets. ANGEW, 64(2), e202412976. (www)

  @article{ , abstract = {X-ray Diffraction Computed Tomography (XRD-CT) represents a cutting-edge method for non-destructive material analysis, offering the unique capability of providing molecular-level information with spatial resolution. In this study, we have applied XRD-CT to investigate pharmaceutically relevant tablets that have been subjected to a range of compression pressures typical in tablet manufacturing. By employing XRD-CT to pharmaceutical tablets, we reveal material changes without tablet destruction, thereby avoiding potential phase transformations during sample preparation that could lead to errors in the interpretation of the processes that have occurred. Utilizing a pressure-sensitive marker, glycolide, we have tracked changes within tablet structures induced by compression, pinpointing locations where glycolide undergoes pressure-induced transformation. Additionally, we conducted a follow-up study with analysis one month later, observing an in situ hydrolysis reaction of glycolide within the tablets. Through the complementary use of electron diffraction, we have elucidated the structure of the hydrolysis product, further enhancing our understanding of temporal changes in the tablets.}, archive = {J_ANGEW}, author = {Julia Gasol-Cardona and Martin R. Ward and Olof Gutowski and Jakub Drnec and Christian Jandl and Danny Stam and Andrew G. P. Maloney and Daniel Markl and Stephen W. T. Price and Iain D. H. Oswald}, doi = {10.1002/anie.202412976}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202412976}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spatial and temporal visualization of polymorphic transformations in pharmaceutical tablets}, volume = {64}, year = {2025}, }
• (2025). Electrochemical identification and quantification of through-plane proton channels in graphene oxide membranes. ANGEW, 64(2), e202412669. (www)

  @article{ , abstract = {Stacked graphene oxide (GO) proton membranes are promising candidates for use in energy devices due to their proton conductivity. Identification of through-plane channels in these membranes is critical but challenging due to their anisotropic nature. Here, we present an electrochemical reduction method for identifying and quantifying through-plane proton channels in GO membranes. The simplicity lies in the operando optical observation of the change in contrast as GO is electrochemically reduced. Here, we find three proton-dominated three-phase interfaces, which are critical for the reduction reactions of GO membranes. Based on these findings, a method is proposed to identify and quantify through-plane channels in stacked GO proton membranes using a simple three-electrode device in combination with real-time imaging of the membrane surface.}, archive = {J_ANGEW}, author = {Yiqing Wang and Siegfried Eigler}, doi = {10.1002/anie.202412669}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202412669}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical identification and quantification of through-plane proton channels in graphene oxide membranes}, volume = {64}, year = {2025}, }
• (2025). The kinetics of carbon-carbon bond formation in metazoan fatty acid synthase and its impact on product fidelity. ANGEW, 64(2), e202412195. (www)

  @article{ , abstract = {Fatty acid synthase (FAS) multienzymes are responsible for de novo fatty acid biosynthesis and crucial in primary metabolism. Despite extensive research, the molecular details of the FAS catalytic mechanisms are still poorly understood. For example, the β-ketoacyl synthase (KS) catalyzes the fatty acid elongating carbon-carbon-bond formation, which is the key catalytic step in biosynthesis, but factors that determine the speed and accuracy of his reaction are still unclear. Here, we report enzyme kinetics of the KS-mediated carbon-carbon bond formation, enabled by a continuous fluorometric activity assay. We observe that the KS is likely rate-limiting to the fatty acid biosynthesis, its kinetics are adapted to the length of the bound fatty acyl chain, and that the KS is also responsible for the fidelity of biosynthesis by preventing intermediates from undergoing KS-mediated elongation. To provide mechanistic insight into KS selectivity, we performed computational molecular dynamics (MD) simulations. We identify positive cooperativity of the KS dimer, which we suggest to affect the conformational variability of the multienzyme. Advancing our knowledge about the KS molecular mechanism will pave the ground for engineering FAS for biotechnology applications and the design of new therapeutics targeting the fatty acid metabolism.}, archive = {J_ANGEW}, author = {Christian Gusenda and Ana R. Calixto and Joana R. Da Silva and Pedro A. Fernandes and Martin Grininger}, doi = {10.1002/anie.202412195}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202412195}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The kinetics of carbon-carbon bond formation in metazoan fatty acid synthase and its impact on product fidelity}, volume = {64}, year = {2025}, }
• (2025). Machine learning assisted prediction of donor numbers: Guiding rational fabrication of polymer electrolytes for lithium-ion batteries. ANGEW, 64(2), e202411437. (www)

  @article{ , abstract = {Polymer electrolytes are of interest in high-energy-density batteries. However, how the intrinsic electron-donating capability of polymer segments involved in coordination affects lithium-ion dissociation/transmission and rationally guides the design and fabrication of electrolytes is a highly exploratory topic. This study proposes a workable method that integrates machine learning with density functional theory to predict donor numbers (DN) for polymer building units. Using this approach, polymer chains with optimized DN are designed, effectively modulating the solvation structure of lithium-ion. Molecular dynamics simulations confirm the positive impact of polymer chains on rapid transport of lithium ions. Experimental validation of the proposed zwitterionic polymer electrolyte (ZPE) showcases satisfactory parameters: ion conductivity (0.59 mS cm −1 ), ion migration numbers (0.82), and activation energy (0.016 eV). Electrochemical analysis on Li|ZPE|Li symmetric batteries demonstrate sustained plating/stripping performance exceeding 3000 hours at a current density of 0.2 mA cm −2 . Assembled NCM|ZPE|Li batteries exhibit stable cycling over 1400 cycles at 4.3 V, with a capacity retention ratio of 92.3 %. Moreover, even under ultra-high voltages of 4.5 V and 4.7 V, NCM|ZPE|Li batteries display stable cycling performances. This approach offers a paradigmatic strategy for polymer molecule design, advancing sustainable battery technologies.}, archive = {J_ANGEW}, author = {Yuqing Gao and Shengguang Qi and Mianrui Li and Tongmei Ma and Huiyu Song and Zhiming Cui and Zhenxing Liang and Li Du}, doi = {10.1002/anie.202411437}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202411437}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning assisted prediction of donor numbers: Guiding rational fabrication of polymer electrolytes for lithium-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Property prediction of bio-derived block copolymer thermoplastic elastomers using graph kernel methods. ANGEW, 64(2), e202411097. (www)

  @article{ , abstract = {Increasing the diversity of bio-based polymers is needed to address the combined problems of plastic pollution and greenhouse gas emissions. The magnitude of the problems necessitates rapid discovery of new materials; however, identification of appropriate chemistries maybe slow using current iterative methods. Machine learning (ML) methods could significantly expedite new material discovery and property identification. Here, PolyAGM, a ML algorithm using graph kernel methods, is introduced and used to predict the properties of block copolymers and identify the responsible structural ‘motifs’. It applies a “fingerprinting” method to convert Graph representations of polymers into numerical vectors. The Graphs explicitly encode the entire copolymer of atoms and bonds such that the sequencing of chemical features and polymer chain length are included, alongside relevant stereochemical information. PolyAGM gives predictions for both thermal and mechanical properties that are in good agreement with experimental measurements. This work focuses on predicting the properties of bio-derived ABA-block polymer thermoplastic elastomers, but the general fingerprinting technique of PolyAGM should be relevant to other application fields.}, archive = {J_ANGEW}, author = {Shannon R. Petersen and David Kohan Marzagão and Georgina L. Gregory and Yichen Huang and David A. Clifton and Charlotte K. Williams and Clive R. Siviour}, doi = {10.1002/anie.202411097}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202411097}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Property prediction of bio-derived block copolymer thermoplastic elastomers using graph kernel methods}, volume = {64}, year = {2025}, }
• (2025). Nonenzymatic hydration of phosphoenolpyruvate: General conditions for hydration in protometabolism by searching across pathways. ANGEW, 64(2), e202410698. (www)

  @article{ , abstract = {Numerous reactions within metabolic pathways have been reported to occur nonenzymatically, supporting the hypothesis that life arose upon a primitive nonenzymatic precursor to metabolism. However, most of those studies reproduce individual transformations or segments of pathways without providing a common set of conditions for classes of reactions that span multiple pathways. In this study, we search across pathways for common nonenzymatic conditions for a recurring chemical transformation in metabolism: alkene hydration. The mild conditions that we identify (Fe oxides such as green rust) apply to all hydration reactions of the rTCA cycle and gluconeogenesis, including the hydration of phosphoenolpyruvate (PEP) to 2-phosphoglycerate (2PGA), which had not previously been reported under nonenzymatic conditions. Mechanistic insights were obtained by studying analogous substrates and through anoxic and radical trapping experiments. Searching for nonenzymatic conditions across pathways provides a complementary strategy to triangulate conditions conducive to the nonenzymatic emergence of a protometabolism.}, archive = {J_ANGEW}, author = {Joris Zimmermann and Atalay Bora Basar and Joseph Moran}, doi = {10.1002/anie.202410698}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202410698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nonenzymatic hydration of phosphoenolpyruvate: General conditions for hydration in protometabolism by searching across pathways}, volume = {64}, year = {2025}, }
• (2025). Target-templated construction of functional proteomimetics using photo-foldamer libraries. ANGEW, 64(2), e202410435. (www)

  @article{ , abstract = {Current methods for proteomimetic engineering rely on structure-based design. Here we describe a design strategy that allows the construction of proteomimetics against challenging targets without a priori characterization of the target surface. Our approach employs (i) a 100-membered photoreactive foldamer library, the members of which act as local surface mimetics, and (ii) the subsequent affinity maturation of the primary hits using systems chemistry. Two surface-oriented proteinogenic side chains drove the interactions between the short helical foldamer fragments and the proteins. Diazirine-based photo-crosslinking was applied to sensitively detect and localize binding even to shallow and dynamic patches on representatively difficult targets. Photo-foldamers identified functionally relevant protein interfaces, allosteric and previously unexplored targetable regions on the surface of STAT3 and an oncogenic K-Ras variant. Target-templated dynamic linking of foldamer hits resulted in two orders of magnitude affinity improvement in a single step. The dimeric K-Ras ligand mimicked protein-like catalytic functions. The photo-foldamer approach thus enables the highly efficient mapping of protein-protein interaction sites and provides a viable starting point for proteomimetic ligand development without a priori structural hypotheses.}, archive = {J_ANGEW}, author = {Edit Wéber and Péter Ábrányi-Balogh and Bence Nagymihály and Dóra K. Menyhárd and Nikolett Péczka and Márton Gadanecz and Gitta Schlosser and Zoltán Orgován and Ferenc Bogár and Dávid Bajusz and Gábor Kecskeméti and Zoltán Szabó and Éva Bartus and Attila Tököli and Gábor K. Tóth and Tibor V. Szalai and Tamás Takács and Elvin de Araujo and László Buday and András Perczel and Tamás A. Martinek and György M. Keserű}, doi = {10.1002/anie.202410435}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202410435}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Target-templated construction of functional proteomimetics using photo-foldamer libraries}, volume = {64}, year = {2025}, }
• (2025). Iodide anion enables a reductive cross-electrophile coupling for preparing tertiary amines. ANGEW, 64(2), e202409688. (www)

  @article{ , abstract = {The reducing power of iodide anion is an underexplored property that can be used for the cross-electrophile coupling of organic molecules. Herein we harness this trait for the preparation of tertiary amines through the combination of two simple reagents: an electrophilic-carbon precursor and an iminium iodide in a dual role – both as nitrogen-containing building block and as reducing agent. The underlying mechanism of this new C−C bond-formation paradigm is explored through a combination of experiment and quantum chemical calculations.}, archive = {J_ANGEW}, author = {Miran Lemmerer and Veronica Tona and David Just and Miloš Vavrík and Boris Maryasin and Giovanni Di Mauro and Andreas B. zur Bonsen and Daniel Kaiser and Nuno Maulide}, doi = {10.1002/anie.202409688}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202409688}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Iodide anion enables a reductive cross-electrophile coupling for preparing tertiary amines}, volume = {64}, year = {2025}, }
• (2025). Electrolyte design enables rechargeable LiFePO4/Graphite batteries from −80 °C to 80 °C. ANGEW, 64(2), e202409409. (www)

  @article{ , abstract = {Lithium iron phosphate (LFP)/graphite batteries have long dominated the energy storage battery market and are anticipated to become the dominant technology in the global power battery market. However, the poor fast-charging capability and low-temperature performance of LFP/graphite batteries seriously hinder their further spread. These limitations are strongly associated with the interfacial lithium (Li)-ion transport. Here we report a wide-temperature-range ester-based electrolyte that exhibits high ionic conductivity, fast interfacial kinetics and excellent film-forming ability by regulating the anion chemistry of Li salt. The interfacial barrier of the battery is quantitatively unraveled by employing three-electrode system and distribution of relaxation time technique. The superior role of the proposed electrolyte in preventing Li 0 plating and sustaining homogeneous and stable interphases are also systematically investigated. The LFP/graphite cells exhibit rechargeability in an ultrawide temperature range of −80 °C to 80 °C and outstanding fast-charging capability without compromising lifespan. Specially, the practical LFP/graphite pouch cells achieve 80.2 % capacity retention after 1200 cycles (2 C) and 10-min charge to 89 % (5 C) at 25 °C and provide reliable power even at −80 °C.}, archive = {J_ANGEW}, author = {Zeheng Li and Yu-Xing Yao and Mengting Zheng and Shuo Sun and Yi Yang and Ye Xiao and Lei Xu and Cheng-Bin Jin and Xin-Yang Yue and Tinglu Song and Peng Wu and Chong Yan and Qiang Zhang}, doi = {10.1002/anie.202409409}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {2}, pages = {e202409409}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrolyte design enables rechargeable LiFePO4/Graphite batteries from −80 °C to 80 °C}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Direct C3−H alkylation and alkenylation of quinolines with enones. ANGEW, 64(1), e202580162. (www)

  @article{ , archive = {J_ANGEW}, author = {Liqing Xu and Xu Wang and Dezhi Yang and Xiaolong Yang and Dong Wang}, doi = {10.1002/anie.202580162}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202580162}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Direct C3−H alkylation and alkenylation of quinolines with enones}, volume = {64}, year = {2025}, }
• (2025). Frontispiece: Dye induced luminescence properties of Gold(I) complexes with near unity quantum efficiency. ANGEW, 64(1), e202580161. (www)

  @article{ , archive = {J_ANGEW}, author = {Vanitha R. Naina and Sebastian Gillhuber and Christian Ritschel and Da Jin and Shubham and Sergei Lebedkin and Claus Feldmann and Florian Weigend and Manfred M. Kappes and Peter W. Roesky}, doi = {10.1002/anie.202580161}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202580161}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Frontispiece: Dye induced luminescence properties of Gold(I) complexes with near unity quantum efficiency}, volume = {64}, year = {2025}, }
• (2025). Angewandte chemie: One journal, many faces. ANGEW, 64(1), e202423069. (www)

  @article{ , archive = {J_ANGEW}, author = {Frank Maaß and Nathalie Weickgenannt}, doi = {10.1002/anie.202423069}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202423069}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Angewandte chemie: One journal, many faces}, volume = {64}, year = {2025}, }
• (2025). Back cover: Stereocontrolled synthesis of chiral helicene-indenido ansa- and half-sandwich metal complexes and their use in catalysis (Angew. chem. int. ed. 1/2025). ANGEW, 64(1), e202421512. (www)

  @article{ , archive = {J_ANGEW}, author = {Tereza Edlová and Jiří Rybáček and Hélène Cattey and Jaroslav Vacek and Lucie Bednárová and Pierre Le Gendre and Adrien T. Normand and Irena G. Stará and Ivo Starý}, doi = {10.1002/anie.202421512}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202421512}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Back cover: Stereocontrolled synthesis of chiral helicene-indenido ansa- and half-sandwich metal complexes and their use in catalysis (Angew. chem. int. ed. 1/2025)}, volume = {64}, year = {2025}, }
• (2025). Matteo atzori. ANGEW, 64(1), e202421408. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202421408}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202421408}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Matteo atzori}, volume = {64}, year = {2025}, }
• (2025). Markus muttenthaler. ANGEW, 64(1), e202420694. (www)

  @article{ , archive = {J_ANGEW}, doi = {10.1002/anie.202420694}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202420694}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Markus muttenthaler}, volume = {64}, year = {2025}, }
• (2025). Inside cover: Robust sandwich-structured thermally activated delayed fluorescence molecules utilizing 11,12-dihydroindolo[2,3-a]carbazole as bridge (Angew. chem. int. ed. 1/2025). ANGEW, 64(1), e202420628. (www)

  @article{ , archive = {J_ANGEW}, author = {Xia Lan and Jiajie Zeng and Jinke Chen and Tao Yang and Xiaobin Dong and Ben Zhong Tang and Zujin Zhao}, doi = {10.1002/anie.202420628}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202420628}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside cover: Robust sandwich-structured thermally activated delayed fluorescence molecules utilizing 11,12-dihydroindolo[2,3-a]carbazole as bridge (Angew. chem. int. ed. 1/2025)}, volume = {64}, year = {2025}, }
• (2025). Inside back cover: Resolving structures of paramagnetic systems in chemistry and materials science by solid-state NMR: The revolving power of ultra-fast MAS (Angew. chem. int. ed. 1/2025). ANGEW, 64(1), e202420435. (www)

  @article{ , archive = {J_ANGEW}, author = {Jonas Koppe and Kevin J. Sanders and Thomas C. Robinson and Arthur L. Lejeune and David Proriol and Sebastian Wegner and Armin Purea and Frank Engelke and Raphaële J. Clément and Clare P. Grey and Andrew J. Pell and Guido Pintacuda}, doi = {10.1002/anie.202420435}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202420435}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inside back cover: Resolving structures of paramagnetic systems in chemistry and materials science by solid-state NMR: The revolving power of ultra-fast MAS (Angew. chem. int. ed. 1/2025)}, volume = {64}, year = {2025}, }
• (2025). Front cover: Mechanochemical “Cage-on-MOF” strategy for enhancing gas adsorption and separation through aperture matching (Angew. chem. int. ed. 1/2025). ANGEW, 64(1), e202420433. (www)

  @article{ , archive = {J_ANGEW}, author = {Yu Liang and Gongfu Xie and Kang-Kai Liu and Meng Jin and Yuanyuan Chen and Xiaoxin Yang and Zong-Jie Guan and Hang Xing and Yu Fang}, doi = {10.1002/anie.202420433}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202420433}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Front cover: Mechanochemical “Cage-on-MOF” strategy for enhancing gas adsorption and separation through aperture matching (Angew. chem. int. ed. 1/2025)}, volume = {64}, year = {2025}, }
• (2025). Actuation performance and versatility of photothermally driven organic crystals. ANGEW, 64(1), e202418570. (www)

  @article{ , abstract = {Photomechanical crystals exhibit mechanical motion upon light irradiation and may thus find applications as actuators. Over the last decades, many photomechanical organic crystals have been developed, commonly via photochemical reactions, particularly photoisomerization. However, photochemical crystal actuation is associated with several drawbacks, including a limited number of available crystals, slow actuation speed (<5 Hz), and narrow wavelength range (<550 nm). Such constraints have hindered the widespread use of crystals as actuation materials. In this minireview, we focus on crystal actuation by employing more universal physical phenomena (the photothermal effect and photothermally resonated natural vibration) and quantitatively evaluate actuation performance. Both mechanisms, particularly the latter, outperformed conventional photomechanical crystal activation in terms of both speed (maximum: 1,350 Hz) and the useful wavelength range (ultraviolet to near-infrared). The oscillation frequencies of the crystals exceeded those of polymers, efficiently filling the gap between soft and hard materials. Both the photothermal effect and natural vibration can actuate any crystal that absorbs light. These two versatile physical actuation mechanisms could expand 40 years of research on photomechanical crystals—which had been based on photochemical reactions—from the realm of chemistry into engineering and lead to their practical applications in actuators and soft robots.}, archive = {J_ANGEW}, author = {Shodai Hasebe and Yuki Hagiwara and Toru Asahi and Hideko Koshima}, doi = {10.1002/anie.202418570}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202418570}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Actuation performance and versatility of photothermally driven organic crystals}, volume = {64}, year = {2025}, }
• (2025). Fundamentals and challenges of ligand modification in heterogeneous electrocatalysis. ANGEW, 64(1), e202417562. (www)

  @article{ , abstract = {The development of efficient catalytic materials in the energy field could promote the structural transformation from traditional fossil fuels to sustainable energy. In heterogeneous catalytic reactions, ligand modification is an effective way to regulate both electronic and steric structures of catalytic sites, thus paving a prospective avenue to design the interfacial structures of heterogeneous catalysts for energy conversion. Although great achievements have been obtained for the study and applications of heterogeneous ligand-modified catalysts, the systematical refinements of ligand modification strategies are still lacking. Here, we reviewed the ligand modification strategy from both the mechanistic and applicable scenarios by focusing on heterogeneous electrocatalysis. We elucidated the ligand-modified catalysts in detail from the perspectives of basic concepts, preparation, regulation of physicochemical properties of catalytic sites, and applications in different electrocatalysis. Notably, we bridged the electrocatalytic performance with the electronic/steric effects induced by ligand modification to gain intrinsic structure-performance relations. We also discussed the challenges and future perspectives of ligand modification strategies in heterogeneous catalysis.}, archive = {J_ANGEW}, author = {Xiangdong Kong and Jiangchen Zhu and Zifan Xu and Zhigang Geng}, doi = {10.1002/anie.202417562}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202417562}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Fundamentals and challenges of ligand modification in heterogeneous electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Application of hard and soft acid-base theory to construct heterometallic materials with metal-oxo clusters. ANGEW, 64(1), e202417548. (www)

  @article{ , abstract = {Heterometallic cluster-based materials offer the potential to incorporate multiple functionalities, leveraging the aggregation effects of clusters and translating this heterogeneity and complexity into unexpected properties that are more than just the sum of their components. However, the rational construction of heterometallic cluster-based materials remains challenging due to the complexity of metal cation coordination and structural unpredictability. This minireview provides insights into a general synthetic strategy based on Hard and Soft Acids and Bases (HSAB) theory, summarizing its advantages in the designed synthesis of discrete heterometallic clusters (intracluster assembly) and infinite heterometallic cluster-based materials (intercluster assembly). Furthermore, it emphasizes the potential to exploit the intrinsic properties of mixed components to achieve breakthroughs across a broad range of applications. The insights from this review are expected to drive the progress of heterometallic cluster-based materials in a controllable and predictable manner.}, archive = {J_ANGEW}, author = {Xiao Qi and Yu-Long Xie and Jing-Yang Niu and Jun-Wei Zhao and Ya-Min Li and Wei-Hui Fang and Jian Zhang}, doi = {10.1002/anie.202417548}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202417548}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Application of hard and soft acid-base theory to construct heterometallic materials with metal-oxo clusters}, volume = {64}, year = {2025}, }
• (2025). Polymer mechanochemistry in confined spaces. ANGEW, 64(1), e202417357. (www)

  @article{ , abstract = {With the development of mechanophores, polymer mechanochemistry has emerged as a powerful tool for creating force-responsive materials with a variety of desired functions, ranging from color change to molecular release. However, it remains challenging to improve the efficiency of mechanochemical activation, especially for mechanophores embedded within polymer networks, which has profound implications for translating mechanochemical responses into materials-centered applications. The physical and chemical conditions under spatial confinement differ significantly from those in the surrounding bulk environment, offering opportunities to facilitate mechanochemical activation. In this Minireview, we discuss and summarize recent progress in polymer mechanochemistry within confined spaces including surfaces/interfaces, polymer assemblies, and other nanostructures, specifically focusing on the effects of spatial confinement on the enhancement of mechanophore activation. We envision that combining confinement effects with advances in molecular and materials engineering will further improve the activation efficiency, capitalizing more fully on the potential of mechanophores toward practical applications.}, archive = {J_ANGEW}, author = {Hui Hu and Yang Zhou and Bin Xi and Yuanchao Li}, doi = {10.1002/anie.202417357}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202417357}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polymer mechanochemistry in confined spaces}, volume = {64}, year = {2025}, }
• (2025). Renaissance of chlorine evolution reaction: Emerging theory and catalytic materials. ANGEW, 64(1), e202417293. (www)

  @article{ , abstract = {Chlorine (Cl 2 ) is one of the most important commodity chemicals that has found widespread utility in chemical industry. Most Cl 2 is currently produced via the chlorine evolution reaction (CER) at the anode of chlor–alkali electrolyzers, for which platinum group-metal (PGM)-based mixed metal oxides (MMOs) have been used for more than half a century. However, MMOs suffer from the use of expensive and scarce PGMs and face selectivity problems due to the parasitic oxygen evolution reaction. Over the last decade, the field of CER catalysis has seen dramatic advances in both the theory and discovery of new catalysts. Theoretical approaches have enabled a fundamental understanding of CER mechanisms and provided catalyst design principles. The exploration of new materials has led to the discovery of CER catalysts other than MMOs, including non-PGM oxides, atomically dispersed single-site catalysts, and organic molecules, with some of which following novel reaction pathways. This minireview provides an overview of the recent advances in CER electrocatalyst research and suggests future directions for this revitalized field.}, archive = {J_ANGEW}, author = {Jinjong Kim and Muhammad Usama and Kai S. Exner and Sang Hoon Joo}, doi = {10.1002/anie.202417293}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202417293}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Renaissance of chlorine evolution reaction: Emerging theory and catalytic materials}, volume = {64}, year = {2025}, }
• (2025). Mechanochemical “Cage-on-MOF” strategy for enhancing gas adsorption and separation through aperture matching. ANGEW, 64(1), e202416884. (www)

  @article{ , abstract = {Post-modification of porous materials with molecular modulators has emerged as a well-established strategy for improving gas adsorption and separation. However, a notable challenge lies in maintaining porosity and the limited applicability of the current method. In this study, we employed the mechanochemical “Cage-on-MOF” strategy, utilizing porous coordination cages (PCCs) with intrinsic pores and apertures as surface modulators to improve the gas adsorption and separation properties of the parent MOFs. We demonstrated the fast and facile preparation of 28 distinct MOF@PCC composites by combining 7 MOFs with 4 PCCs with varying aperture sizes and exposed functional groups through a mechanochemical reaction in 5 mins. Only the combinations of PCCs and MOFs with closely matched aperture sizes exhibited enhanced gas adsorption and separation performance. Specifically, MOF-808@PCC-4 exhibited a significantly increased C 2 H 2 uptake (+64 %) and a longer CO 2 /C 2 H 2 separation retention time (+40 %). MIL-101@PCC-4 achieved a substantial C 2 H 2 adsorption capacity of 6.11 mmol/g. This work not only highlights the broad applicability of the mechanochemical “Cage-on-MOF” strategy for the functionalization of a wide range of MOFs but also establishes potential design principles for the development of hybrid porous materials with enhanced gas adsorption and separation capabilities, along with promising applications in catalysis and intracellular delivery.}, archive = {J_ANGEW}, author = {Yu Liang and Gongfu Xie and Kang-Kai Liu and Meng Jin and Yuanyuan Chen and Xiaoxin Yang and Zong-Jie Guan and Hang Xing and Yu Fang}, doi = {10.1002/anie.202416884}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202416884}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanochemical “Cage-on-MOF” strategy for enhancing gas adsorption and separation through aperture matching}, volume = {64}, year = {2025}, }
• (2025). Direct C3−H alkylation and alkenylation of quinolines with enones. ANGEW, 64(1), e202416451. (www)

  @article{ , abstract = {Conversion of quinoline C−H bonds into C−C bonds is essential for obtaining the enormous array of derivatives required for pharmaceutical and agrochemical development. Despite over a century of synthetic efforts, direct alkylation and alkenylation at C3−H positions in a wide array of quinoline precursors remain predominantly challenging and elusive. This report outlines the first successful quinoline C3−H alkylation and alkenylation reactions, exhibiting exceptional regio- and stereoselectivity, all achieved under redox-neutral and transition-metal-free conditions. The method involves a three-step, one-pot or two-pot sequence, including 1,4-dearomative addition, functionalization at C3, and elimination or transalkylation to produce 3-alkylated/alkenylated quinolines. The presence of a carbonyl group in these products allows for further synthetic manipulations, enabling the production of cyanides, amides, amines, and simple alkyl derivatives.}, archive = {J_ANGEW}, author = {Liqing Xu and Xu Wang and Dezhi Yang and Xiaolong Yang and Dong Wang}, doi = {10.1002/anie.202416451}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202416451}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct C3−H alkylation and alkenylation of quinolines with enones}, volume = {64}, year = {2025}, }
• (2025). Transmembrane ion channels: From natural to artificial systems. ANGEW, 64(1), e202416200. (www)

  @article{ , abstract = {Natural channel proteins allow the selective permeation of ions, water or other nutritious entities across bilayer membranes, facilitating various essential physiological functions in living systems. Inspired by nature, chemists endeavor to simulate the structural features and transport behaviors of channel proteins through biomimetic strategies. In this review, we start from introducing the inherent traits of channel proteins such as their crystal structures, functions and mechanisms. Subsequently, different kind of synthetic ion channels including their design principles, dynamic regulations and therapeutic applications were carefully reviewed. Finally, the potential challenges and opportunities in this research field were also carefully discussed. It is anticipated that this review could provide some inspiring ideas and future directions towards the construction of novel bionic ion channels with higher-level structures, properties, functions and practical applications.}, archive = {J_ANGEW}, author = {Tengfei Yan and Junqiu Liu}, doi = {10.1002/anie.202416200}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202416200}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Transmembrane ion channels: From natural to artificial systems}, volume = {64}, year = {2025}, }
• (2025). Stereocontrolled synthesis of chiral helicene-indenido ansa- and half-sandwich metal complexes and their use in catalysis. ANGEW, 64(1), e202414698. (www)

  @article{ , abstract = {Despite recent tremendous progress in the synthesis of nonplanar chiral aromatics, and helicenes in particular, their conversion to half-sandwich or sandwich transition metal complexes still lags behind, although they represent an attractive family of modular and underexplored chiral architectures with a potential catalytic use. In this work, starting from various chiral helicene-indene proligands, we prepared the enantio- and diastereopure oxa[6]- and oxa[7]helicene-indenido half-sandwich Rh I and Rh III complexes and oxa[7]helicene-bisindenido ansa -metallocene Fe II complex. To document their use, oxahelicene-indenido half-sandwich Rh III complexes were employed as chiral catalysts in enantioselective C−H arylation of benzo[ h ]quinolines with 1-diazonaphthoquinones to afford a series of axially chiral biaryls in mostly good to high yields and in up to 96 : 4 er . Thus, we developed stereocontrolled synthesis of chiral helicene-indenido ansa - and half-sandwich metal complexes, successfully demonstrated the first use of such helicene Cp-related metal complexes in enantioselective catalysis, and described an unusual sequence of efficient central-to-helical-to-planar-to-axial chirality transfer.}, archive = {J_ANGEW}, author = {Tereza Edlová and Jiří Rybáček and Hélène Cattey and Jaroslav Vacek and Lucie Bednárová and Pierre Le Gendre and Adrien T. Normand and Irena G. Stará and Ivo Starý}, doi = {10.1002/anie.202414698}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202414698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereocontrolled synthesis of chiral helicene-indenido ansa- and half-sandwich metal complexes and their use in catalysis}, volume = {64}, year = {2025}, }
• (2025). Dye induced luminescence properties of Gold(I) complexes with near unity quantum efficiency. ANGEW, 64(1), e202414517. (www)

  @article{ , abstract = {To study the effect of a dye on the photoluminescence (PL) properties of metal complexes, a series of gold(I) complexes were synthesized, containing a 7-amino-4-methylcoumarin luminophore. The complexes are comprised of a coumarin moiety featuring different ancillary ligands, specifically N-heterocyclic carbenes, triphenylphosphine, and diphenyl-2-pyridylphosphine. The synthesized gold(I) complexes are luminescent both in solution and the solid state at room temperature and 77 K. Complexes of different nuclearity, i.e., mono-, di- and trinuclear compounds were synthesized. A clear trend between the nuclearity and the quantum yields can be seen. The coumarin dye not only improves the PL properties, but also enhances the luminescence of trinuclear clusters, which are otherwise known to be weak emitters in solution. The optical absorption properties were investigated in detail by quantum chemical calculations.}, archive = {J_ANGEW}, author = {Vanitha R. Naina and Sebastian Gillhuber and Christian Ritschel and Da Jin and Shubham and Sergei Lebedkin and Claus Feldmann and Florian Weigend and Manfred M. Kappes and Peter W. Roesky}, doi = {10.1002/anie.202414517}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202414517}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dye induced luminescence properties of Gold(I) complexes with near unity quantum efficiency}, volume = {64}, year = {2025}, }
• (2025). Robust sandwich-structured thermally activated delayed fluorescence molecules utilizing 11,12-dihydroindolo[2,3-a]carbazole as bridge. ANGEW, 64(1), e202414488. (www)

  @article{ , abstract = {Constructing folded molecular structures is emerging as a promising strategy to develop efficient thermally activated delayed fluorescence (TADF) materials. Most folded TADF materials have V-shaped configurations formed by donors and acceptors linked on carbazole or fluorene bridges. In this work, a facile molecular design strategy is proposed for exploring sandwich-structured molecules, and a series of novel and robust TADF materials with regular U-shaped sandwich conformations are constructed by using 11,12-dihydroindolo[2,3-a]carbazole as bridge, xanthone as acceptor, and dibenzothiophene, dibenzofuran, 9-phenylcarbazole and indolo[3,2,1-JK]carbazole as donors. They hold outstanding thermal stability with ultrahigh decomposition temperatures (556–563 °C), and exhibit fast delayed fluorescence and excellent photoluminescence quantum efficiencies (86 %–97 %). The regular and close stacking of acceptor and donors results in rigidified molecular structures with efficient through-space interaction, which are conducive to suppressing intramolecular motion and reducing reorganized excited-state energy. The organic light-emitting diodes (OLEDs) using them as emitters exhibit excellent electroluminescence performances, with maximum external quantum efficiencies of up to 30.6 %, which is a leading value for the OLEDs based on folded TADF emitters. These results demonstrate the proposed strategy of employing 11,12-dihydroindolo[2,3-a]carbazole as bridge for planar donors and acceptors to construct efficient folded TADF materials is applicable.}, archive = {J_ANGEW}, author = {Xia Lan and Jiajie Zeng and Jinke Chen and Tao Yang and Xiaobin Dong and Ben Zhong Tang and Zujin Zhao}, doi = {10.1002/anie.202414488}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202414488}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Robust sandwich-structured thermally activated delayed fluorescence molecules utilizing 11,12-dihydroindolo[2,3-a]carbazole as bridge}, volume = {64}, year = {2025}, }
• (2025). High-yielding nanobelt formation by chirality-assisted synthesis. ANGEW, 64(1), e202414059. (www)

  @article{ , abstract = {Shape-persistent conjugated nanobelts (CNBs) are fascinating synthetic targets. However, in most cases these are made in low overall yields by applying strategies of macrocyclization followed by (multiple) ring fusion reactions for nanobelt formation. Here, we describe the high yielding synthesis of enantiopure chiral nanobelts in 84 % yield by applying chirality-assisted synthesis (CAS). The chiral nanobelts were investigated by UV/Vis and CD spectroscopy. By DFT calculations the aromaticity of these structures is discussed.}, archive = {J_ANGEW}, author = {Yogendra Singh and Moritz P. Schuldt and Frank Rominger and Michael Mastalerz}, doi = {10.1002/anie.202414059}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202414059}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-yielding nanobelt formation by chirality-assisted synthesis}, volume = {64}, year = {2025}, }
• (2025). Dinitrogen reduction and functionalization by a siloxide supported thulium-potassium complex for the formation of ammonia or hydrazine derivatives. ANGEW, 64(1), e202414051. (www)

  @article{ , abstract = {The dinitrogen (N 2 ) chemistry of lanthanides remains less developed compared to the d-block metals and lanthanide-promoted N 2 functionalization chemistry in well-defined lanthanide complexes remains elusive. Here we report the synthesis and characterization (SQUID, EPR, DFT, X-Ray) of the siloxide supported heterobimetallic (Tm/K) complexes [{KTm(OSi(O t Bu) 3 ) 3 } 2 ( μ - η 2 : η 2 -N 2 )] ( 1 ) and [K 3 {Tm(OSi(O t Bu) 3 ) 3 } 2 ( μ - η 2 : η 2 -N 2 )] ( 2 ). Complex 2 provides a rare example of a metal complex of the triply reduced N 2 3− radical. The structure of 2 differs from the few previously reported N 2 3− complexes as it presents two Tm and three K cations binding the N 2 3− radical, facilitating N 2 functionalization. Notably, the K 3 Tm 2 -bound N 2 3− moiety reacts with excess H + to form NH 4 Cl in 18 % yield, and with MeOTf at room temperature to yield the dimethyl hydrazido complex [K 2 {Tm(OSi(O t Bu) 3 ) 3 } 2 ( μ -(CH 3 )NN(CH 3 ))] ( 3 ). Protonolysis of 3 yields MeHN−NMeH ⋅ 2HCl in 18 % yield.}, archive = {J_ANGEW}, author = {R. A. Keerthi Shivaraam and Thayalan Rajeshkumar and Rosario Scopelliti and Ivica Z̆ivković and Laurent Maron and Marinella Mazzanti}, doi = {10.1002/anie.202414051}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202414051}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Dinitrogen reduction and functionalization by a siloxide supported thulium-potassium complex for the formation of ammonia or hydrazine derivatives}, volume = {64}, year = {2025}, }
• (2025). Catalytic N-formylation of CO2 by atomically precise Au8Pd1(DPPF)42+ clusters into a two-dimensional Metal–Organic framework. ANGEW, 64(1), e202414030. (www)

  @article{ , abstract = {By highly efficient ligand-exchange strategy, atomically precise Au 8 Pd 1 (PPh 3 ) 8 2+ (PPh 3 =triphenylphosphine) cluster can be transformed into a Au 8 Pd 1 (DPPF) 4 2+ (DPPF=1,1′-bis(diphenylphosphino)ferrocene) cluster that can maintain the atomic-packing structure but overcome the lability of Au 8 Pd 1 (PPh 3 ) 8 2+ . Catalytic evaluation for the CO 2 hydrogenation coupled with o-phenylenediamine demonstrates that the Au 8 Pd 1 (DPPF) 4 2+ catalyst can remarkably enhance both activity and stability compared to the Au 8 Pd 1 (PPh 3 ) 8 2+ catalyst. More notably, the direct construction of a two-dimensional metal–organic framework (2D MOF) can be elaborately accomplished in the formylation process of o-phenylenediamine, CO 2 and H 2 with zinc nitrate enabled by the Au 8 Pd 1 (DPPF) 4 2+ catalyst. The 2D MOF further enables the capture and transformation of CO 2 to combine in the organic synthesis with epoxides under mild conditions. This work provides opportunities for creating highly active cluster sites for the chemical recycling of CO 2 .}, archive = {J_ANGEW}, author = {Xiao Cai and Yiqi Tian and Hao Wang and Shuangshuang Huang and Xu Liu and Guangjun Li and Weiping Ding and Yan Zhu}, doi = {10.1002/anie.202414030}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202414030}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Catalytic N-formylation of CO2 by atomically precise Au8Pd1(DPPF)42+ clusters into a two-dimensional Metal–Organic framework}, volume = {64}, year = {2025}, }
• (2025). Reversible structural phase transitions in zero-dimensional Cu(I)-based metal halides for dynamically tunable emissions. ANGEW, 64(1), e202413991. (www)

  @article{ , abstract = {Exploring structural phase transitions and luminescence mechanisms in zero-dimensional (0D) metal halides poses significant challenges, that are crucial for unlocking the full potential of tunable optical properties and diversifying their functional capabilities. Herein, we have designed two inter-transformable 0D Cu(I)-based metal halides, namely (C 19 H 18 P) 2 CuI 3 and (C 19 H 18 P) 2 Cu 4 I 6 , through distinct synthesis conditions utilizing identical reactants. Their optical properties and luminescence mechanisms were systematically elucidated by experiments combined with density functional theory calculations. The bright cyan-fluorescent (C 19 H 18 P) 2 CuI 3 with high photoluminescence quantum yield (PLQY) of 77 % is attributed to the self-trapped exciton emission. Differently, the broad yellow-orange fluorescence of (C 19 H 18 P) 2 Cu 4 I 6 displays a remarkable PLQY of 83 %. Its luminescence mechanism is mainly attributed to the combined effects of metal/halide-to-ligand charge transfer and cluster-centered charge transfer, which effects stem from the strong Cu−Cu bonding interactions in the (Cu 4 I 6 ) 2− clusters. Moreover, (C 19 H 18 P) 2 CuI 3 and (C 19 H 18 P) 2 Cu 4 I 6 exhibit reversible structural phase transitions. The elucidation of the phase transitions mechanism has paved the way for an unforgeable anti-counterfeiting system. This system dynamically shifts between cyan and yellow-orange fluorescence, triggered by the phase transitions, bolstering security and authenticity. This work enriches the luminescence theory of 0D metal halides, offering novel strategies for optical property modulation and fostering optical applications.}, archive = {J_ANGEW}, author = {Ran An and Qishun Wang and Yuan Liang and Pengye Du and Pengpeng Lei and Haizhu Sun and Xinyu Wang and Jing Feng and Shuyan Song and Hongjie Zhang}, doi = {10.1002/anie.202413991}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413991}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reversible structural phase transitions in zero-dimensional Cu(I)-based metal halides for dynamically tunable emissions}, volume = {64}, year = {2025}, }
• (2025). Diphenylacetylene-incorporating octaphyrin: A rigid macrocycle with readily separable conformational isomers. ANGEW, 64(1), e202413962. (www)

  @article{ , abstract = {An expanded carbaporphyrinoid analogue, octaphyrin(2,1,1,1,2,1,1,1), containing two rigid diphenylacetylene moieties is reported. In contrast to traditional pyrrolic macrocycles where flexible conformers coexist in dynamic equilibrium, this macrocycle exists as two separable, conformationally stable stereoisomers, denoted as 1A and 1B . The conformational effect of both conformers, as well as their protonated forms, were thoroughly studied using NMR spectroscopy, UV/Vis, and single crystal X-ray diffraction analyses. Importantly, heating conformer 1B leads to its irreversible conversion to 1A , whereas in its protonated form, 1A ⋅ 2MSA undergoes irreversible transformation to 1B ⋅ 2MSA at lower temperatures. These temperature-dependent features establish a foundation for developing new accumulated heat sensors, as demonstrated by the use of the present octaphyrins as a customized thermochromic indicator in steam sterilization. The present study thus underscores how the conformational rigidity of these new polypyrrolic macrocycles imparts properties that are distinct from historically flexible expanded porphyrinoids.}, archive = {J_ANGEW}, author = {Puren Han and Zhiming Duan and Min Shao and Jonathan L. Sessler and Chuanhu Lei}, doi = {10.1002/anie.202413962}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413962}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diphenylacetylene-incorporating octaphyrin: A rigid macrocycle with readily separable conformational isomers}, volume = {64}, year = {2025}, }
• (2025). Nonflammable fluorinated electrolyte realizing high voltage anode-free zn dual-ion batteries. ANGEW, 64(1), e202413959. (www)

  @article{ , abstract = {Due to the low decomposition potential of H 2 O and its corrosive effect to Zn foil, the Zn metal battery with aqueous electrolytes operates within a narrow electrochemical window and exhibits low anode utilization ratio. Fluorinated carbonate ester, exhibiting low highest occupied molecular orbital (HOMO) energy level, is suitable for constructing high-voltage batteries, yet its application in Zn metal battery has been scarcely explored. Herein, we propose an electrolyte based on fluorinated solvents and ethoxy (pentafluoro) cyclotriphosphazene (PFPN) additive, which exhibits a high decomposition voltage of 2.75 V in Zn batteries. The fluorinated carbonate esters possess non-flammability and exhibit reduced solvation capacity which in turn promotes the incorporation of anions into Zn 2+ solvation shell. Consequently, an anion-derived interface layer is formed on Zn anode, aiding the compact and planar growth of deposited Zn. Therefore, the Zn//Zn cell exhibits an impressive Zn utilization of 91 % for 140 h, a level seldom reported previously. Benefitting from the oxidation resistant solvents and cathode-electrolyte interface layer formed by PFPN additive, the Zn//graphite dual-ions battery shows an extended cycling life of 1000 cycles. Furthermore, an anode-free cell was constructed and stably operated for 100 cycles, with a notably high average discharge midpoint voltage of 1.84 V.}, archive = {J_ANGEW}, author = {Kang Zhou and Gaohong Liu and Xiao Zhu and Gaopan Liu and Xiaomeng Yu and Ziyang Guo and Yonggang Wang}, doi = {10.1002/anie.202413959}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413959}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nonflammable fluorinated electrolyte realizing high voltage anode-free zn dual-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Synergistic Photoredox/Palladium catalyzed enantioconvergent carboxylation of racemic heterobiaryl (Pseudo)Halides with CO2. ANGEW, 64(1), e202413949. (www)

  @article{ , abstract = {Herein, we report a synergistic photoredox/palladium catalytic system for the efficient enantioconvergent synthesis of axially chiral esters from racemic heterobiaryl (pseudo)halides (bromides/triflates) with CO 2 and alkyl bromides under mild conditions. A wide range of axially chiral esters were obtained in good to high yields with excellent enantioselectivities. Detailed mechanistic studies unveiled that the ratio of photocatalyst and palladium catalyst exhibited significant impact on the chemo- and enantioselectivities of the reaction. Kinetic studies and control experiments supported the proposed mechanism involving cascade asymmetric carboxylation followed by S N 2 substitution. The achievement of high enantioselectivity relies not only on the choice of synergistic metallaphotoredox catalysts but also on the utilization of alkyl bromides, which trap the generated chiral carboxylic anions in situ, thus preventing their immediate racemization.}, archive = {J_ANGEW}, author = {Bihai Ye and Lei Su and Kaiting Zheng and Shen Gao and Jiawang Liu}, doi = {10.1002/anie.202413949}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413949}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergistic Photoredox/Palladium catalyzed enantioconvergent carboxylation of racemic heterobiaryl (Pseudo)Halides with CO2}, volume = {64}, year = {2025}, }
• (2025). Red blood cell-derived small extracellular vesicles inhibit influenza virus through surface-displayed sialic acids. ANGEW, 64(1), e202413946. (www)

  @article{ , abstract = {Disrupting the conserved multivalent binding of hemagglutinin (HA) on influenza A virus (IAV) to sialic acids (SAs) on the host cell membrane offers a robust strategy to block viral attachment and infection, irrespective of antigenic evolution or drug resistance. In this study, we exploit red blood cell-derived small extracellular vesicles (RBC sEVs) as nanodecoys by harnessing their high abundance of surface-displayed SAs to interact with IAV through multivalent HA-SA interactions. This high-avidity binding inhibits viral adhesion to the cell surface, effectively preventing both attachment and infection in a dose-dependent manner. Notably, enzymatic removal of SAs from RBC sEVs significantly diminishes their anti-IAV efficacy. Our findings indicate that RBC sEVs possess intrinsic anti-IAV properties due to their native multivalent SAs and hold considerable promise as antiviral therapeutics.}, archive = {J_ANGEW}, author = {Niangui Cai and Xiaozhen Zhan and Qingyuan Zhang and Haonan Di and Chen Chen and Yunyun Hu and Xiaomei Yan}, doi = {10.1002/anie.202413946}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413946}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Red blood cell-derived small extracellular vesicles inhibit influenza virus through surface-displayed sialic acids}, volume = {64}, year = {2025}, }
• (2025). Rigid ligand confined synthesis of carbon supported dimeric fe sites with high-performance oxygen reduction reaction activity for quasi-solid-state rechargeable zn-air batteries. ANGEW, 64(1), e202413933. (www)

  @article{ , abstract = {Dimeric metal sites (DiMSs) in carbon-based single atom catalysts (SACs) offer distinct advantages in optimizing the adsorption energies of the catalytic intermediates and reaction pathways over single atom sites, which inspires the investigations on the rational design of DiMSs-based SACs and the accurate discernment of catalytic mechanisms. Here, dimeric Fe sites on carbon blacks (DiFe-N/CBs) are prepared using the precursor of metal-organic complex with a controlled structure, and the rigid ligand confinement secures the preservation of dimeric Fe sites during the thermal treatment. DiFe-N/CBs shows excellent electrocatalytic performance for oxygen reduction reaction (ORR) with a high half-wave potential of 0.917 V, and excellent durability with negligible activity decay. Theoretical studies reveal that the dimeric Fe sites have an optimal adsorption of OOH* with the Yeager-type binding, illustrating the advantages of DiMSs over SAs in catalyzing ORR. The rechargeable aqueous and quasi-solid-state Zn-air batteries assembled using DiFe-N/CBs-based air cathodes achieve small voltage gaps after long term charge/discharge test, showing great promises for practical applications. This synthetic strategy serves a novel platform to produce a scope of catalysts incorporating multimeric metal sites, and studies on the catalytic mechanism lay the foundation for establishing cooperative effect for multidentate adsorption reactions.}, archive = {J_ANGEW}, author = {Lingbo Zong and Mengke Li and Ping Li and Kaicai Fan and Lei Wang}, doi = {10.1002/anie.202413933}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413933}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rigid ligand confined synthesis of carbon supported dimeric fe sites with high-performance oxygen reduction reaction activity for quasi-solid-state rechargeable zn-air batteries}, volume = {64}, year = {2025}, }
• (2025). Harnessing the unconventional cubic phase in 2D LaNiO3 perovskite for highly efficient urea oxidation. ANGEW, 64(1), e202413932. (www)

  @article{ , abstract = {Phase engineering is a critical strategy in electrocatalysis, as it allows for the modulation of electronic, geometric, and chemical properties to directly influence the catalytic performance. Despite its potential, phase engineering remains particularly challenging in thermodynamically stable perovskites, especially in a 2D structure constraint. Herein, we report phase engineering in 2D LaNiO 3 perovskite using the strongly non-equilibrium microwave shock method. This approach enables the synthesis of conventional hexagonal and unconventional trigonal and cubic phases in LaNiO 3 by inducing selective phase transitions at designed temperatures, followed by rapid quenching to allow precise phase control while preserving the 2D porous structure. These phase transitions induce structural distortions in the [LaO] + layers and the hybridization between Ni 3 d and O 2 p states, modifying local charge distribution and enhancing electron transport during the six-electron urea oxidation process (UOR). The cubic LaNiO 3 offers optimal electron transport and active site accessibility due to its high structural symmetry and open interlayer spacing, resulting in a low onset potential of 1.27 V and a Tafel slope of 33.1 mV dec −1 for UOR, outperforming most current catalysts. Our strategy features high designability in phase engineering, enabling various electrocatalysts to harness the power of unconventional phases.}, archive = {J_ANGEW}, author = {Zhiao Wu and Miao Fan and Huiyu Jiang and Jiao Dai and Kaisi Liu and Rong Hu and Shutong Qin and Weilin Xu and Yonggang Yao and Jun Wan}, doi = {10.1002/anie.202413932}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413932}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Harnessing the unconventional cubic phase in 2D LaNiO3 perovskite for highly efficient urea oxidation}, volume = {64}, year = {2025}, }
• (2025). Tuning reaction kinetics of fluorinated molecules to construct robust solid electrolyte interphases on SiOx anode. ANGEW, 64(1), e202413927. (www)

  @article{ , abstract = {Introducing fluorinated electrolyte additives to construct LiF-rich solid-electrolyte interphase (SEI) on Si-based anodes is proven an effective strategy for coping with its massive volume changes during cycling. However, most current research on fluorine-containing additives focuses on their thermodynamics of decomposition, lacking studies on the correlation between the molecular structure of additives and their decomposition kinetics. Herein, two fluorinated ester additives, diethyl fluoromalonate (F1DEM) and diethyl 2,2-difluoromalonate (F2DEM) were designed and synthesized. Through combining a wealth of characterizations and simulations, it is revealed that despite the similar reduction thermodynamics, the favorable reduction kinetics of single-fluorinated F1DEM facilitate a LiF-rich layer during the early stage of SEI formation, contributing to the formation of a more robust SEI on SiO x anode compared to the difluorinated F2DEM. Consequently, the proposed additive achieves excellent cycling stability (84 % capacity retention after 1000 cycles) for 5 Ah 21700 cylindrical batteries under practical testing conditions. By unveiling the role of reaction kinetics, a long-overlooked aspect for the study of electrolyte additives, this work sheds light on how to construct a stable SEI on Si-based anodes.}, archive = {J_ANGEW}, author = {Shiming Chen and Zhikang Deng and Jiangxiao Li and Wenguang Zhao and Bowen Nan and Yue Zuo and Jianjun Fang and Yuxiang Huang and Zu-Wei Yin and Feng Pan and Luyi Yang}, doi = {10.1002/anie.202413927}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413927}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tuning reaction kinetics of fluorinated molecules to construct robust solid electrolyte interphases on SiOx anode}, volume = {64}, year = {2025}, }
• (2025). Artificial electron channels enable contact prelithiation of li-ion battery anodes with ultrahigh li-source utilization. ANGEW, 64(1), e202413926. (www)

  @article{ , abstract = {Contact prelithiation is widely used to compensate for the initial capacity loss of lithium-ion batteries (LIBs). However, the low utilization of the Li source, which suffers from the deteriorated contact interfaces, results in cycling degeneration. Herein, Li−Ag alloy-based artificial electron channels (AECs) are established in Li source/graphite anode contact interfaces to promote Li-source conversion. Due to the shielding effect of the Li−Ag alloy (50 at . % Li) on Li-ion diffusion, the dry-state interfacial corrosion is restricted. The unblocked electronic conduction across the AEC-involved interface not only facilitates the Li-source conversion but also accelerates the prelithiation kinetics during the wet-state process, resulting in an ultrahigh Li-source utilization (90.7 %). Implementing AEC-assisted prelithiation in a LiNi 0.5 Co 0.2 Mn 0.3 O 2 pouch cell yields a 35.8 % increase in energy density and stable cycling over 600 cycles. This finding affords significant insights into the construction of an efficient prelithiation technology for the development of high-energy LIBs.}, archive = {J_ANGEW}, author = {Xinyang Yue and Yu-Xing Yao and Jing Zhang and Si-Yu Yang and Wei Hao and Zeheng Li and Cheng Tang and Yuanmao Chen and Chong Yan and Qiang Zhang}, doi = {10.1002/anie.202413926}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413926}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Artificial electron channels enable contact prelithiation of li-ion battery anodes with ultrahigh li-source utilization}, volume = {64}, year = {2025}, }
• (2025). Origin of enhanced oxygen evolution in restructured Metal–Organic frameworks for anion exchange membrane water electrolysis. ANGEW, 64(1), e202413916. (www)

  @article{ , abstract = {Metal–Organic Frameworks (MOFs), praised for structural flexibility and tunability, are prominent catalyst prototypes for exploring oxygen evolution reaction (OER). Yet, their intricate transformations under OER, especially in industrial high-current environments, pose significant challenges in accurately elucidating their structure–activity correlation. Here, we harnessed an electrooxidation process for controllable MOF reconstruction, discovering that Fe doping expedites Ni(Fe) MOF structural evolution, accompanied by the elongation of Ni−O bonds, monitored by in situ Raman and UV/Visible spectroscopy. Theoretical modeling further reveals that Fe doping and defect-induced tensile strain in the NiO 6 octahedra augments the metal ds-O p hybridization, optimizing their adsorption behavior and augmenting OER activity. The reconstructed Ni(Fe) MOF, serving as the anode in anion exchange membrane water electrolysis, achieves a noteworthy current density of 3300 mA cm −2 at 2.2 V while maintaining equally stable operation 500 mA cm −2 for 300 h and 1000 mA cm −2 for 170 h. This undertaking elevates our comprehension of OER catalyst reconstruction, furnishing promising avenues for designing highly efficacious catalysts across electrochemical platforms.}, archive = {J_ANGEW}, author = {Ying Li and Liu Yang and Xiaolei Hao and Xiaopei Xu and Lingling Xu and Bo Wei and Zhongwei Chen}, doi = {10.1002/anie.202413916}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413916}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Origin of enhanced oxygen evolution in restructured Metal–Organic frameworks for anion exchange membrane water electrolysis}, volume = {64}, year = {2025}, }
• (2025). The key descriptors for predicting the exciton binding energy of organic photovoltaic materials. ANGEW, 64(1), e202413913. (www)

  @article{ , abstract = {Exciton binding energy ( E b ) is a key parameter to determine the mechanism and performance of organic optoelectronic devices. Small E b benefits to reduce the interfacial energy offset and the energy loss of organic solar cells. However, quantum-chemical calculations of the E b in solid state with considering electronic polarization effects are extremely time-consuming. Furthermore, current studies lack critical descriptors. Here, we use data-driven machine learning (ML) to accelerate the computation and identify the key descriptors most relevant to the solid-state E b . The results verify two key descriptors associated with molecular and aggregation-state properties for efficient prediction of the solid-state E b . Moreover, a very high accuracy is achieved by using the extreme gradient boosting algorithm, with the Pearson's correlation coefficient of 0.92. Finally, we use this ML model to predict the E b of thin films, which is difficult to achieve using the current quantum-chemical calculations due to the large structural disorder. Remarkably, the predicted thin-film E b values are fully consistent with the results of temperature-dependent photoluminescence spectra. Therefore, our work provides an accurate and efficient approach to predict the solid-state E b and would be helpful to accelerate the exploitation of novel promising organic photovoltaic materials.}, archive = {J_ANGEW}, author = {Lingyun Zhu and Miaofei Huang and Guangchao Han and Zhixiang Wei and Yuanping Yi}, doi = {10.1002/anie.202413913}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413913}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The key descriptors for predicting the exciton binding energy of organic photovoltaic materials}, volume = {64}, year = {2025}, }
• (2025). Stapled peptides as inhibitors of mRNA deadenylation. ANGEW, 64(1), e202413911. (www)

  @article{ , abstract = {Therapeutic intervention targeting mRNA typically aims at reducing the levels of disease-causing sequences. Achieving the opposite effect of blocking the destruction of beneficial mRNA remains underexplored. The degradation of mRNA starts with the removal of poly(A) tails, reducing their stability and translational activity, which is mainly regulated by the CCR4-NOT complex. The subunit NOT9 binds various RNA binding proteins, that recruit mRNA in a sequence-specific manner to the CCR4-NOT complex to promote their deadenylation. These RNA binding proteins interact with NOT9 through a helical NOT9 binding motif, which we used as a starting point for development of the hydrocarbon stapled peptide NIP-2 . The peptide ( K D =60.4 nM) was able to inhibit RNA-binding (IC 50 =333 nM) as well as the deadenylation activity of the CCR4-NOT complex in vitro while being cell-permeable (cell-permeability EC 50 =2.44 μM). A co-crystal structure of NIP-2 bound to NOT9 allowed further optimization of the peptide through point mutation leading to NIP-2-H27A-N 3 ( K D =122 nM) with high cell permeability (cell-permeability EC 50 =0.34 μM). The optimized peptide was able to inhibit deadenylation of target mRNAs when used in HeLa cells at a concentration of 100 μM, demonstrating the feasibility of increasing mRNA stability.}, archive = {J_ANGEW}, author = {Sunit Pal and Ilja Gordijenko and Stefan Schmeing and Somarghya Biswas and Yasemin Akbulut and Raphael Gasper and Peter 't Hart}, doi = {10.1002/anie.202413911}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413911}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stapled peptides as inhibitors of mRNA deadenylation}, volume = {64}, year = {2025}, }
• (2025). Supramolecular modulation for selective mechanochemical iron-catalyzed olefin oxidation. ANGEW, 64(1), e202413901. (www)

  @article{ , abstract = {The development of a mechanochemical Fe-catalyzed Wacker oxidation of olefins with a sustainable and benign procedure holds significant promise for industrial applications. However, navigating the intricate interactions inherent in ball-milling conditions to fine-tune reaction selectivity remains a formidable challenge. Herein, leveraging the dispersive and/or trapping properties of cyclodextrins, an innovative mechanochemical approach is developed through the integration of cyclodextrins into a Fe-catalyzed system, enabling a streamlined Wacker oxidation process from simple and/or commercially available alkenes. Our efforts have yielded optimized mechanochemical conditions demonstrating exceptional reactivity and selectivity in generating a diverse array of ketone products, markedly enhancing catalytic efficiency compared to conventional batch methods. Mechanistic investigations have revealed a predominantly Markovnikov-selective catalytic cycle, effectively minimizing undesired alcohol formation, hydrogenation, and the other competing pathways, boosting both reaction yield and selectivity.}, archive = {J_ANGEW}, author = {Chuan Jiang and Ye Wu and Yongjin Zhang and Jiawei Zong and Ning Wang and Guohua Liu and Rui Liu and Han Yu}, doi = {10.1002/anie.202413901}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Supramolecular modulation for selective mechanochemical iron-catalyzed olefin oxidation}, volume = {64}, year = {2025}, }
• (2025). Visible-photo-assisted phase switching of antiferroelectric-to-ferroelectric orders in an i3−-intercalated 2D perovskite. ANGEW, 64(1), e202413898. (www)

  @article{ , abstract = {Antiferroelectric (AFE) has emerged as a promising branch of electroactive materials, due to intriguing physical attributes stemming from the electric field-induced antipolar-to-polar phase transformation. However, the requirement of extremely high electric field strength to switch adjacent sublattice polarization poses great challenges for exploiting new molecular AFE system. Although photoirradiation is striking as a noncontact and nondestructive manipulation tool to optimize physical properties, optical control of antiferroelectricity still remains unexplored. Here, by adopting light-sensitive I 3 − anion into 2D perovskite family, we design a new I 3 − -intercalated molecular AFE of ( t -ACH) 2 EA 2 Pb 3 I 10 (I 3 ) 0.5 ⋅ ((H 3 O)(H 2 O)) 0.5 ( 1 , t -ACH= trans -4-aminomethyl-1-cyclohexanecarboxylate, EA=ethylammonium). The I 3 − -intercalating gives an ultra-narrow band gap of 1.65 eV with strong absorption. In term of AFE structure, the anti-parallel alignment of electric dipoles results in a large spontaneous polarization of 4.3 μC/cm 2 . Strikingly, 1 merely shows AFE behaviour in the dark even under ultrahigh voltage, while the field-induced ferroelectric state can be facilely obtained upon visible illumination. Such unprecedented visible-photo-assisted phase switching ascribes to the incorporation of photoactive I 3 − anions that reduces AFE-to-ferroelectric switching barrier. This pioneering work on the photo-assisting transformation of ferroic orders paves a way to develop future photoactive materials with potential applications.}, archive = {J_ANGEW}, author = {Yi Liu and Fu Li and Liwei Tang and Xitao Liu and Xi Zeng and Wenjing Li and Hao Rong and Hongbin Zhang and Junhua Luo and Zhihua Sun}, doi = {10.1002/anie.202413898}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413898}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-photo-assisted phase switching of antiferroelectric-to-ferroelectric orders in an i3−-intercalated 2D perovskite}, volume = {64}, year = {2025}, }
• (2025). Promoting water dissociation and weakening active hydrogen adsorption to boost the hydrogen transfer reaction over a Cu−Ag superlattice electrocatalyst. ANGEW, 64(1), e202413897. (www)

  @article{ , abstract = {The prerequisite for electrocatalytic hydrogenation reactions (EHRs) is H 2 O splitting to form surface hydrogen species (*H), which occupy catalytic sites and lead to mismatched coverage of *H and reactants, resulting in unsatisfactory activity and selectivity. Thus, modulating the splitting pathway of H 2 O is significant for optimizing the EHR process. Herein, a Cu−Ag alloy with a superlattice structure of staggered-ordered Cu and Ag is theoretically predicted and experimentally proven to undergo a pathway for H 2 O splitting called the hydrogen transfer reaction (HTR) in the water layer, which involves the formation of *H, the capture of *H by a water cluster to form H*(H 2 O) x and subsequent hydrogenation reactions by H*(H 2 O) x . Taking acetylene hydrogenation as a model case, the as-proposed HTR pathway could lead to a relaxation hydrogenation process to modulate the matching degree of C 2 H 2 and *H, thus enabling a 91.2 % C 2 H 4 Faradaic efficiency at a partial current density of 0.38 A cm −2 , greatly outperforming its counterpart without a superlattice structure.}, archive = {J_ANGEW}, author = {Chuanqi Cheng and Fanpeng Chen and Bin Zhang and Bo-Hang Zhao and Xiwen Du}, doi = {10.1002/anie.202413897}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413897}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promoting water dissociation and weakening active hydrogen adsorption to boost the hydrogen transfer reaction over a Cu−Ag superlattice electrocatalyst}, volume = {64}, year = {2025}, }
• (2025). Ni-catalyzed enantioselective reductive Cyclization/Amidation and amination of 1,6-enynes and 1,7-enynes. ANGEW, 64(1), e202413892. (www)

  @article{ , abstract = {Transition-metal-catalyzed hydroamination of unsaturated hydrocarbons is an appealing synthetic tool for the construction of high value-added chiral amines. Despite significant progress in the asymmetric hydroamination of alkenes, allenes, and 1,3-dienes, asymmetric hydroamination of 1,6-enynes or 1,7-enynes remains rather limited due to the enormous challenges in controlling the chemoselectivity and stereoselectivity of the reaction. Herein, we report a Ni-catalyzed chemo- and enantioselective reductive cyclization/amidation and amination of 1,6-enynes and 1,7-enynes using dioxazolones or anthranils as nitrene-transfer reagents. This mild, modular, and practical protocol provides rapid access to a variety of enantioenriched 2-pyrrolidone and 2-piperidone derivatives bearing an aminomethylene group at the 4-position in good yields (up to 83 %) with excellent enantioselectivities (46 examples, up to 99 % ee). Mechanistic experiments and density functional theory calculations indicate that the reaction is initiated by hydronickelation of alkynes followed by migratory insertion into alkenes, rather than by a [2+2+1] oxidative addition process of nickel to alkenes and alkynes.}, archive = {J_ANGEW}, author = {Shengwei Hu and Xiaoqin Wang and Tianbao Wu and Zhengtian Ding and Minyan Wang and Wangqing Kong}, doi = {10.1002/anie.202413892}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413892}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ni-catalyzed enantioselective reductive Cyclization/Amidation and amination of 1,6-enynes and 1,7-enynes}, volume = {64}, year = {2025}, }
• (2025). The electron-density distribution of UCl4 and its topology from X-ray diffraction. ANGEW, 64(1), e202413883. (www)

  @article{ , abstract = {The chemistry of electrons in actinide complexes and materials is still poorly understood and represents a serious challenge and opportunity for experiment and theory. The study of the electron density distribution of the ground state of such systems through X-ray diffraction represents a unique opportunity to quantitatively investigate different chemical bonding interactions at once, but was considered “almost impossible” on heavy-atom systems, until very recently. Here, we present a combined experimental and theoretical investigation of the electron density distribution in UCl_ 4 crystals and comparison with the previously reported spin density distribution from polarized neutron diffraction. All approaches provide a consistent picture in terms of electron and spin density distribution, and chemical bond characterization. More importantly, the synergy between experiments and quantum-mechanical calculations allows to highlight the remarkable sensitivity of X-ray diffraction to electrons in materials.}, archive = {J_ANGEW}, author = {Alessandro Cossard and Christopher G. Gianopoulos and Jacques K. Desmarais and Silvia Casassa and Carlo Gatti and Alessandro Erba and A. Alan Pinkerton}, doi = {10.1002/anie.202413883}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413883}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The electron-density distribution of UCl4 and its topology from X-ray diffraction}, volume = {64}, year = {2025}, }
• (2025). LAMP-MS for locus-specific visual quantification of DNA 5 mC and RNA m6A using ultra-low input. ANGEW, 64(1), e202413872. (www)

  @article{ , abstract = {Enhancing the effectiveness of utilizing circulating cell-free DNA (cfDNA) for disease screening remains a challenge, necessitating improved sensitivity, specificity, cost-efficiency, and patient adherence. We present here LAMP-MS, an innovative technology that integrates linear amplification with single-base quantitative nucleic acid mass spectrometry on silicon chips. This approach overcomes several limitations in utilizing cfDNA 5-methylcytosine (5 mC) status for colorectal cancer (CRC) screening. LAMP-MS enables unbiased amplification of as little as 1 ng of cfDNA, site-specifically quantify methylation levels of multiple 5 mC sites, thereby facilitating cost-effective, high-resolution quantitative detection of cfDNA methylation markers. We have validated the accuracy of DNA methylation determination using DNA probes and cfDNA from patient plasma samples, confirmed by mass spectrometric peak areas. Additionally, we have further shown this Mass Array technology could be expanded to also quantify RNA m 6 A modification sites. Combining the ability to work with ultra-low input materials and a visually interpretable output, LAMP-MS stands out as a promising method for real-world applications in clinics and laboratories for nucleic acid methylation detection and quantification.}, archive = {J_ANGEW}, author = {Runyu Xie and Xiaotong Yang and Weizhi He and Zhongguang Luo and Wenshuai Li and Chu Xu and Xiaolong Cui and Wei Zhang and Ning Wei and Xiaolan Wang and Yixiang Shi and Chuan He and Jie Liu and Lulu Hu}, doi = {10.1002/anie.202413872}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413872}, shortjournal = {Angew. Chem. Int. Edit.}, title = {LAMP-MS for locus-specific visual quantification of DNA 5 mC and RNA m6A using ultra-low input}, volume = {64}, year = {2025}, }
• (2025). Perfect is perfect: Nickel prussian blue analogue as a high-efficiency electrocatalyst for hydrogen peroxide production. ANGEW, 64(1), e202413866. (www)

  @article{ , abstract = {Prussian blue analogues (PBA) are a large family of functional materials with diverse applications such as in electrochemical fields. However, their use in the emerging two-electron oxygen reduction reaction for clean production of hydrogen peroxide (H 2 O 2 ) is lagging. Herein, a general solvent exchange induced reconstruction strategy is demonstrated, through which an abnormal NiNi-PBA superstructure is synthesized as a high-performance electrocatalyst for H 2 O 2 generation. The resultant NiNi-PBA superstructure has a stoichiometric composition with saturated lattice water, and a leaf-like morphology composed of interconnected small-size nanosheets with identical orientation and predominate {210} side surface exposure. Our studies show that the Ni−N centers on {210} facets are the active sites, and the saturated lattice H 2 O favors a six-coordinated environment that results in high selectivity. The “perfect” structure including stoichiometric composition and ideal facet exposure leads to a high selectivity of ~100 % and H 2 O 2 yield of 5.7 mol g −1 h −1 , superior to the reported MOF-based electrocatalysts and most other electrocatalysts.}, archive = {J_ANGEW}, author = {Yamin Xi and Yitong Xiang and Chaoqi Zhang and Tong Bao and Yingying Zou and Jin Zou and Guangfeng Wei and Lei Wang and Hongyi Xu and Chengzhong Yu and Chao Liu}, doi = {10.1002/anie.202413866}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413866}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Perfect is perfect: Nickel prussian blue analogue as a high-efficiency electrocatalyst for hydrogen peroxide production}, volume = {64}, year = {2025}, }
• (2025). Loading lewis Acid/Base pair on metal nanocluster for catalytic ugi reaction. ANGEW, 64(1), e202413861. (www)

  @article{ , abstract = {Constructing structurally robust and catalytically active metal nanoclusters for catalyzing multi-component reactions is an interesting while challenging task. Inspired by Lewis acid and Lewis base catalysis, we realized the combination of both Lewis acid and Lewis base sites on the surface of a stable gold nanocluster Au 35 Cd 2 . The catalytic potential of Au 35 Cd 2 in four-component Ugi reaction was explored, demonstrating high activity and exceptional recyclability. In-depth mechanism studies indicate that the catalytic synergy of the Lewis acid/base pair is crucial for the high efficiency of Au 35 Cd 2 -catalyzed Ugi reaction. Bearing the stable structure, multiple activation sites and hierarchical chirality, Au 35 Cd 2 is expected to display further interesting catalytic performance such as asymmetric catalysis.}, archive = {J_ANGEW}, author = {Ji-Qiang Fan and Yanshuang Li and Wen Wu Xu and Man-Bo Li}, doi = {10.1002/anie.202413861}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413861}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Loading lewis Acid/Base pair on metal nanocluster for catalytic ugi reaction}, volume = {64}, year = {2025}, }
• (2025). Mesostructure-specific configuration of *CO adsorption for selective CO2 electroreduction to c2+ products. ANGEW, 64(1), e202413832. (www)

  @article{ , abstract = {The multi-carbon (C 2+ ) alcohols produced by electrochemical CO 2 reduction, such as ethanol and n -propanol, are considered as indispensable liquid energy carriers. In most C−C coupling cases, however, the concomitant gaseous C 2 H 4 product results in the low selectivity of C 2+ alcohols. Here, we report rational construction of mesostructured CuO electrocatalysts, specifically mesoporous CuO (m-CuO) and cylindrical CuO (c-CuO), enables selective distribution of C 2+ products. The m-CuO and c-CuO show similar selectivity towards total C 2+ products (≥76 %), but the corresponding predominant products are C 2+ alcohols (55 %) and C 2 H 4 (52 %), respectively. The ordered mesostructure not only induces the surface hydrophobicity, but selectively tailors the adsorption configuration of *CO intermediate: m-CuO prefers bridged adsorption, whereas c-CuO favors top adsorption as revealed by in situ spectroscopies. Computational calculations unravel that bridged *CO adsorbate is prone to deep protonation into *OCH 3 intermediate, thus accelerating the coupling of *CO and *OCH 3 intermediates to generate C 2+ alcohols; by contrast, top *CO adsorbate is apt to undergo conventional C−C coupling process to produce C 2 H 4 . This work illustrates selective C 2+ products distribution via mesostructure manipulation, and paves a new path into the design of efficient electrocatalysts with tunable adsorption configuration of key intermediates for targeted products.}, archive = {J_ANGEW}, author = {Zaiqi Li and Bin Sun and Difei Xiao and Hongli Liu and Zeyan Wang and Yuanyuan Liu and Zhaoke Zheng and Peng Wang and Ying Dai and Baibiao Huang and Hefeng Cheng}, doi = {10.1002/anie.202413832}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413832}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mesostructure-specific configuration of *CO adsorption for selective CO2 electroreduction to c2+ products}, volume = {64}, year = {2025}, }
• (2025). Single-luminophore molecular engineering for rapidly phototunable solid-state luminescence. ANGEW, 64(1), e202413827. (www)

  @article{ , abstract = {Smart materials enabling emission intensity or wavelength tuning by light stimulus have attracted attention in cutting-edge fields. However, due to the general limitation of the dense molecular stacking (in solid states, especially in crystals) on photoresponsivity, constructing rapidly phototunable solid-state luminescent systems remains challenging. Herein, we present a new luminophore that serves as both a photoresponsive and a luminous group with enhanced conformational freedom to attain this goal, namely, relying on photoexcitation-induced molecular conformational change of an ionized persulfurated arene based on weak intermolecular aliphatic C−H⋅⋅⋅π interaction. Together with the phosphorescence characteristic of the molecule itself, rapidly enhanced phosphorescence upon irradiation can be observed in a series of phase states, like solution state, crystal, and amorphous state, especially with a high photoresponsive rate of 0.033 s −1 in crystal state that is superior to the relevant reported cases. Moreover, a rapidly phototunable afterglow effect is achieved by extending this molecule into some polymer-based doping systems, endowing the system with unique dynamic imaging and fast photopatterning capabilities. This single-luminophore molecular engineering and underlying mechanism have implications for building other condensed functional materials, principally for those with stimuli responses in solid states.}, archive = {J_ANGEW}, author = {Hao Sun and Zidong Yu and Chenzi Li and Man Zhang and Shen Shen and Mingde Li and Mouwei Liu and Zhongyu Li and Dayu Wu and Liangliang Zhu}, doi = {10.1002/anie.202413827}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413827}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-luminophore molecular engineering for rapidly phototunable solid-state luminescence}, volume = {64}, year = {2025}, }
• (2025). “One-stone, two-birds”: Zinc-rich Metal–Organic frameworks as precursors for high-entropy zn-air battery electrocatalysts with hierarchical pore structures. ANGEW, 64(1), e202413826. (www)

  @article{ , abstract = {The active sites of inexpensive transition metal electrocatalysts are sparse and singular, thus high-entropy alloys composed of non-precious metals have attracted considerable attention due to their multi-component synergistic effects. However, the facile synthesis of high-entropy alloy composites remains a challenge. Herein, we report a “one-stone, two-birds” method utilizing zinc (Zn)-rich metal–organic frameworks as precursors, by virtue of the low boiling point of Zn (907 °C) and its high volatility in alloys, high-entropy alloy carbon nanocomposite with a layered pore structure was ultimately synthesized. The experimental results demonstrate that the volatilization of zinc can prevent metal agglomeration and contribute to the formation of uniformly dispersed high-entropy alloy nanoparticles at slower pyrolysis and cooling rates. Simultaneously, the volatilization of Zn plays a crucial role in creating the hierarchically porous structure. Compared to the zinc-free HEA/NC-1, the HEA/NC-5 derived from the precursor containing 0.8 Zn exhibit massive micropores and mesopores. The resulting nanocomposites represent a synergistic effect between highly dispersed metal catalytic centers and hierarchical adsorption sites, thus achieving excellent electrocatalytic oxygen reduction performance with low catalyst loading compared to commercial Pt/C. This convenient zinc-rich precursor method can be extended to the production of more high-entropy alloys and various application fields.}, archive = {J_ANGEW}, author = {Jianwen Su and Yinji Wan and Long Feng and Dingding Huang and Hsing Kai Chu and Xuan Zhang and Xiaoye Geng and Yonggang Wang and Ruiqin Zhong and Ruqiang Zou}, doi = {10.1002/anie.202413826}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413826}, shortjournal = {Angew. Chem. Int. Edit.}, title = {“One-stone, two-birds”: Zinc-rich Metal–Organic frameworks as precursors for high-entropy zn-air battery electrocatalysts with hierarchical pore structures}, volume = {64}, year = {2025}, }
• (2025). Partitioning / self-assembly of artificial water channels – Toward controlled permselectivity through bilayer membrane. ANGEW, 64(1), e202413816. (www)

  @article{ , abstract = {Artificial water channels (AWCs) have been extensively explored to mimic natural proteins, which enables to effectively transport water while blocking ions. As one of the first AWCs, self-assembled I-quartets (HCx) have showcased high water-permselectivity that can be enhanced by improving their distribution and stability within membrane. The use of long alkyl chains ( n >8) is constrained by their low solubility and aggregation. Herein, we considered cycloalkyl moieties, explored for the increase of the solubility favoring enhanced partition and/ for their self-assembly behaviors resulting the formation of effective stable water-channels with increased water permeability in bilayer membranes. This class of cycloalkyl-ureido-ethyl-imidazole amphiphilic (CxUH) channel could serve as a new reference for the effective design of self-assembled artificial water channels, it may give rise to the applications in desalination or in water treatment.}, archive = {J_ANGEW}, author = {Dan-Dan Su and Arie van der Lee and Mihail Barboiu}, doi = {10.1002/anie.202413816}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413816}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Partitioning / self-assembly of artificial water channels – Toward controlled permselectivity through bilayer membrane}, volume = {64}, year = {2025}, }
• (2025). A photo-switchable peptide fibril esterase. ANGEW, 64(1), e202413810. (www)

  @article{ , abstract = {Recent attempts to mimic enzyme catalysis using simple, short peptides have been successful in enhancing various reactions, but the on-demand, temporal or spatial regulation of such processes by external triggers remains a great challenge. Light irradiation is an ideal trigger for regulating molecular functionality, since it can be precisely manipulated in time and space, and because most reaction mediums do not react to light. We herein report the selection of a photo-switchable amphiphilic peptide catalyst from a small library of isomeric peptides, each containing an azobenzene-based light responsive group and a catalytic histidine residue. In its native fibrillar form, the selected peptide is efficiently and enantio-selectively active for ester hydrolysis, but after irradiation by UV light inducing trans -to- cis azobenzene isomerization, the fibrils disassemble to amorphous aggregates that are much less catalytically active. Significantly, this esterase-like activity can be manipulated multiple times, as the fibrillar peptide assembly is reversibly reduced and restored upon alternate irradiation by UV and visible light, respectively. We propose that this research may shine light on the origin of complex functions in early chemical evolution. Furthermore, it paves the way to regulate additional functions for peptide nanotechnology, such as replication, charge transfer, and delivery.}, archive = {J_ANGEW}, author = {Mousumi Samanta and Noy Saad and Dinghao Wu and Niek S. A. Crone and Karina Abramov-Harpaz and Clil Regev and Rivka Cohen-Luria and Aimee L. Boyle and Yifat Miller and Alexander Kros and Gonen Ashkenasy}, doi = {10.1002/anie.202413810}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413810}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A photo-switchable peptide fibril esterase}, volume = {64}, year = {2025}, }
• (2025). A novel anion receptor additive for −40 °C sodium metal batteries by Anion/Cation solvation engineering. ANGEW, 64(1), e202413806. (www)

  @article{ , abstract = {Sodium metal batteries, known for their high theoretical specific capacity, abundant reserves, and promising low-temperature performance, have garnered significant attention. However, the large ionic radius of Na + and sluggish transport kinetics across the interfacial structure hinder their practical application. Previous reviews have rarely regulated electrolyte performance from the perspective of anions, as important components of the electrolyte, the regulation mechanism is not well understood. Herein, a novel anion receptor additive, 4-aminophenylboronic acid pinacol ester (ABAPE), is proposed to weaken the coupling between anions and cations and accelerate Na + transport kinetics. The results of theoretical calculations and X-ray photoelectron spectroscopy with deep Ar-ion etching demonstrate that the introduction of this additive alters the solvation structure of Na + , reduces the desolvation barrier and forms a stable and dense electrode-electrolyte interface. Moreover, ABAPE forms hydrogen bonds (−NH ⋅ ⋅ ⋅ O/F) with H 2 O/HF, effectively preventing the hydrolysis of NaPF 6 and stabilizing acidic species. Consequently, the Na||Na symmetric cell exhibits excellent long-cycle performance of 500 h at 1 mA cm −2 and 0.5 mAh cm −2 . The Na||Na 3 V 2 (PO 4 ) 3 (NVP) cell with the addition of ABAPE maintains a capacity retention of 84.29 % at 1 C after 1200 cycles and presents no capacity decay over 150 cycles at −40 °C.}, archive = {J_ANGEW}, author = {Meng Li and Jinlong Jiang and Ying Chen and Shoushuang Huang and Xiaoyu Liu and Jin Yi and Yong Jiang and Bing Zhao and Wenrong Li and Xueliang Sun and Jiujun Zhang}, doi = {10.1002/anie.202413806}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413806}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A novel anion receptor additive for −40 °C sodium metal batteries by Anion/Cation solvation engineering}, volume = {64}, year = {2025}, }
• (2025). Integrating molecular motions in ternary cocrystals for NIR-II photothermal conversion. ANGEW, 64(1), e202413805. (www)

  @article{ , abstract = {Organic photothermal conversion materials hold immense promise for various applications owing to their structural flexibility. Recent research has focused on enhancing near-infrared (NIR) absorption and mitigating radiative transition processes. In this study, we have developed a viable approach to the design of photothermal conversion materials through the construction of ternary organic cocrystals, by introducing a third component as a molecular blocker and motion unit into a binary donor–acceptor system. Superstructural and photophysical properties of the ternary cocrystals were characterized using various spectroscopic techniques. The role of the molecular blocker in radical stabilization and photothermal conversion was demonstrated. Intriguingly, the motions of the entire pyrene molecules in the cocrystal have been observed by the results of variable temperature single-crystal X-ray diffraction. The excellent performance of the ternary cocrystal as a photothermal material was validated through efficient NIR-II photothermal and solar-driven water evaporation experiments. The efficiency of water evaporation reached 88.7 %, with a corresponding evaporation rate of 1.29 kg m −2 h −1 , representing excellent performance among pure organic small molecular photothermal conversion materials. Our research underscores the introduction of molecular blockers and motion units to stabilize radicals and produce outstanding photothermal conversion materials, offering new pathways for developing efficient and stable photothermal conversion materials.}, archive = {J_ANGEW}, author = {Jia-Chuan Liu and Tao Li and Huiru Yu and Jim Y. Huang and Pei-Xian Li and Ze-Yu Ruan and Pei-Yu Liao and Chenxin Ou and Yuanning Feng and Ming-Liang Tong}, doi = {10.1002/anie.202413805}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413805}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Integrating molecular motions in ternary cocrystals for NIR-II photothermal conversion}, volume = {64}, year = {2025}, }
• (2025). Manganese carbodiimide (MnNCN): A new heterogeneous mn catalyst for the selective synthesis of nitriles from alcohols. ANGEW, 64(1), e202413799. (www)

  @article{ , abstract = {Earth-abundant manganese oxides (MnO x ) were competitive candidates when screening catalysts for ammoxidation of alcohols into nitriles due to their redox property. However, over-oxidation and possible acid-catalyzed hydrolysis of nitriles into amides still limited the application of MnO x in nitrile synthesis. In this work, manganese carbodiimide (MnNCN) was first reported to be robust for the ammoxidation of alcohols into nitriles, avoiding over-oxidation and the hydrolysis. Besides the high activity and selectivity, MnNCN demonstrated wide substrate scope including the ammoxidation of primary alcohols into nitriles, the oxidative C−C bonds cleavage and ammoxidation of secondary alcohols, phenyl substituted aliphatic alcohols, and diols into nitriles. Controlled experiments and DFT calculation results revealed that the excellent catalytic performance of MnNCN originated from its high ability in the activation of O 2 molecules, and favorable oxidative dehydrogenation of C=N bonds in the aldimine intermediates (RCH=NH) into nitriles, inhibiting the competitive side reaction of the oxidation of aldehydes into carboxylic acids, followed to amide byproducts. Moreover, the hydrolysis of nitriles was also inhibited over MnNCN for its weak acidity as compared with MnO x . This study provided new insights into Mn-catalyzed aerobic oxidations as a highly important complement to manganese oxides.}, archive = {J_ANGEW}, author = {Xixi Liu and Bo Han and Chongbei Wu and Peng Zhou and Meilin Jia and Liangfang Zhu and Zehui Zhang}, doi = {10.1002/anie.202413799}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413799}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manganese carbodiimide (MnNCN): A new heterogeneous mn catalyst for the selective synthesis of nitriles from alcohols}, volume = {64}, year = {2025}, }
• (2025). Synergize strong and reactive metal-support interactions to construct sub-2 nm metal phosphide cluster for enhanced selective hydrogenation activities. ANGEW, 64(1), e202413788. (www)

  @article{ , abstract = {Strong metal-support interactions (SMSI) are crucial for stabilizing sub-2 nm metal sites, e.g. single atom (M 1 ) or cluster (M n ). However, further optimizing sub-2 nm sites to break the activity–stability trade-off due to excessive interactions remains significant challenges. Accordingly, for the first time, we propose synergizing SMSI with reactive metal-support interactions (RMSI). Comprehensive characterization confirms that the SMSI stabilizes the metal and regulates the aggregation of Ni 1 into Ni n site within sub-2 nm. Meanwhile, RMSI modulates Ni n through sufficiently activating P in the support and eventually generates sub-2 nm metal phosphide Ni 2 P cluster (Ni 2 P n ). The synergetic metal-support interactions triggered the adaptive coordination and electronic structure optimization of Ni 2 P n , leading to the desired substrate adsorption-desorption kinetics. Consequently, the activity of Ni 2 P n site greatly enhanced towards the selective hydrogenations of p -chloronitrobenzene and alkynyl alcohol. The formation rates of target products are up to 20.2 and 3.0 times greater than that of Ni 1 and Ni n site, respectively. This work may open a new direction for metal-support interactions and promote innovation and application of active sites below 2 nm.}, archive = {J_ANGEW}, author = {Zemin Chen and Xinyu Li and Guangyue Xu and Tianci Xiao and Dechen Wang and Chufei Wang and Kaihang Zhang and Jiong Li and Yang Pan and Yan Qiao and Ying Zhang}, doi = {10.1002/anie.202413788}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413788}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synergize strong and reactive metal-support interactions to construct sub-2 nm metal phosphide cluster for enhanced selective hydrogenation activities}, volume = {64}, year = {2025}, }
• (2025). Single-atom catalysts with p-block metals surpass transition-metal counterparts in the photocatalytic H2O2 production. ANGEW, 64(1), e202413769. (www)

  @article{ , abstract = {Growing interest in p-block metal single-atom catalysts (PM-SACs) is driven by their low toxicity, economic viability, and transition metal-like catalytic properties. However, selection criteria for p-block single-atom species and catalytic mechanisms of PM-SACs remain unclear. This study explores the catalytic abilities of PM-SACs and their transition metal counterparts (TM-SACs) based on polymetric carbon nitride (PCN) for photocatalytic hydrogen peroxide (H 2 O 2 ) production. Using thermodynamic barriers as a key descriptor, it was found that PM-SACs can surpass TM-SACs in H 2 O 2 production due to a lower energy barrier for *OOH intermediate formation resulting from optimized p-p hybridization. Specifically, Sb-SAC based on PCN shows the highest apparent quantum yield of 35.3 % at 400 nm. This study offers a rationale for the utilization of p-block SACs in the context of sustainable chemical synthesis.}, archive = {J_ANGEW}, author = {Haijiao Lu and Hanqing Yin and Jeffrey Harmer and Mu Xiao and Jiakang You and Peng Chen and Tongen Lin and Aijun Du and Zhiliang Wang and Lianzhou Wang}, doi = {10.1002/anie.202413769}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413769}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Single-atom catalysts with p-block metals surpass transition-metal counterparts in the photocatalytic H2O2 production}, volume = {64}, year = {2025}, }
• (2025). Two-photon clusteroluminescence enabled by through-space conjugation for in vivo bioimaging. ANGEW, 64(1), e202413751. (www)

  @article{ , abstract = {Clusteroluminescence (CL) materials without largely conjugated structures have gained significant attention due to their unique photophysical properties and potential in bioimaging. However, low luminescence efficiency and short emission wavelength limit their development. This work designs three luminogens with CL properties (CLgens) by introducing n -electron-involved through-space conjugation (TSC) into diarylmethane. Apart from single-photon excited long-wavelength (686 nm) and high-efficiency (29 %) CL, two-photon clusteroluminescence (TPCL) is successfully achieved in such small luminogens with only two isolated heteroatomic units. TSC stabilized in the aggregate state has been proven to realize efficient spatial electron delocalization similar to conventionally conjugated compounds. Encouraged by the excellent TPCL properties, two-photon imaging of blood vessels in vivo and biocompatibility verification utilizing CLgens are also achieved. This work illustrates the essential role of TSC in promoting nonlinear optical properties of CLgens and may facilitate further design and development of the next generation of bioprobes with excellent biocompatibility.}, archive = {J_ANGEW}, author = {Jianyu Zhang and Hanchen Shen and Zuping Xiong and Lidong Du and Moxin Li and Xinwen Ou and Xinyan Zhu and Jacky W. Y. Lam and Tzu-Ming Liu and Changhuo Xu and Haoke Zhang and Ben Zhong Tang}, doi = {10.1002/anie.202413751}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413751}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Two-photon clusteroluminescence enabled by through-space conjugation for in vivo bioimaging}, volume = {64}, year = {2025}, }
• (2025). Rational design of diatomic active sites for elucidating oxygen evolution reaction performance trends. ANGEW, 64(1), e202413749. (www)

  @article{ , abstract = {Diatomic catalysts, especially those with heteronuclear active sites, have recently attracted significant attention for their advantages over single-atom catalysts in reactions with relatively high energy barrier, e.g. oxygen evolution reaction. Rational design and synthesis of heteronuclear diatomic catalysts are of immense significance but have so far been plagued by the lack of a definitive correlation between structure and catalytic properties. Here, we report macrocyclic precursor constrained strategy to fabricate series of transition metal (M T , Ni, Co, Fe, Mn, or Cu)-noble (M N , Ir or Ru) centers in carbon material. One notable performance trend is observed in the order of Cu−M N <Mn−M N <Fe−M N <M N <Co−M N <Ni−M N . Meanwhile, the pathway has been not altered, still following the traditional adsorption reaction mechanism. The effect of the M T atoms on the performances could possibly originate from the distinct adsorption/desorption behaviors of key intermediates (i.e. *OH, *O and/or *OOH), strongly implying that Δ G *OOH – Δ G *OH could be used as the performance descriptor. We believe that our work provides useful strategy for synthesis of diatomic active sites with sole coordination configuration and varied composition, and in-depth insight to their catalytic mechanism, which could be used for further optimization of diatomic catalysts towards oxygen electrocatalysis.}, archive = {J_ANGEW}, author = {Nanfeng Xu and Yuxiang Jin and Qiunan Liu and Meng Yu and Xiao Wang and Chao Wang and Wei Tu and Zhirong Zhang and Zhigang Geng and Kazu Suenaga and Fangyi Cheng and Erhong Song and Zhangquan Peng and Junyuan Xu}, doi = {10.1002/anie.202413749}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413749}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design of diatomic active sites for elucidating oxygen evolution reaction performance trends}, volume = {64}, year = {2025}, }
• (2025). Amplification and attenuation of asymmetry via kinetically controlled seed-induced supramolecular polymerization. ANGEW, 64(1), e202413747. (www)

  @article{ , abstract = {The amplification of asymmetry in supramolecular polymers has recently garnered significant attention. While asymmetry amplification has predominantly been explored under thermodynamic conditions, the kinetic aspect of this process unveils intriguing observations, yet is scarcely reported in the literature. Herein, drawing inspiration from macromolecular systems, we propose a novel strategy for enhancing asymmetry in supramolecular polymers through a seed-induced supramolecular polymerization approach under kinetic conditions, employing a naphthalene diimide-derived monomer ( ANSG ) for template-induced supramolecular polymerization, utilizing adenosine triphosphate (ATP) and pyrophosphate (PPi) as templates. A chiral seed comprising [ANSG-ATP] S effectively amplifies the overall supramolecular asymmetry when exposed to a mixture of achiral templates (PPi) and monomers ( ANSG ), owing to its efficient seeding characteristics under kinetic conditions. As a result of efficient co-operativity, conversely, employing an achiral seed [ANSG-PPi ] S in a mixture of chiral templates (ATP) and monomers ( ANSG ) results in the attenuation of asymmetry, highlighting the effective modulation achievable through the seeding approach, an unprecedented observation in the field. Exploiting the efficient aggregation-induced emission enhancement (AIEE) of the resultant supramolecular polymers further extends the amplification and attenuation of circularly polarized luminescence (CPL) as a potential function.}, archive = {J_ANGEW}, author = {Angshuman Das and Saikat Ghosh and Subi J. George}, doi = {10.1002/anie.202413747}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413747}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Amplification and attenuation of asymmetry via kinetically controlled seed-induced supramolecular polymerization}, volume = {64}, year = {2025}, }
• (2025). Direct synthesis of perovskite quantum dot photoresist for direct photolithography. ANGEW, 64(1), e202413741. (www)

  @article{ , abstract = {Perovskite quantum dots (PQDs) photoresists are promising building blocks for photolithographically patterned devices. However, their complex synthesis and combination processes limit their optical properties and potential patterning applications. Here, we present an exceptionally simple strategy for the synthesis of PQDs photoresist. Unlike traditional approaches that involve centrifugation, separation, and combination processes, our direct synthesis technique using polymerizable acrylic monomer as solvent to fabricate PQDs photoresists without complex post-synthesis process. We demonstrate that the change in solubility of the precursors is the main reason for the formation of PQDs in the polymerizable monomer. By direct photolithography, colorful PQD patterns with high photoluminescence quantum yields and high thickness are successfully demonstrated. This work opens a new avenue for the direct synthesis of PQDs photoresist, expanding their applications in various integrated applications, such as photonic, energy harvesting, and optoelectronic devices.}, archive = {J_ANGEW}, author = {Xiaochen Zhou and Zhiyuan Gao and Jianbing Shi and Tianhe Li and Shunsheng Wei and Peng Huang and Pingping Zhang and Gaoling Yang}, doi = {10.1002/anie.202413741}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413741}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Direct synthesis of perovskite quantum dot photoresist for direct photolithography}, volume = {64}, year = {2025}, }
• (2025). MXene triggered free radical polymerization in minutes toward all-printed zn-ion hybrid capacitors and beyond. ANGEW, 64(1), e202413728. (www)

  @article{ , abstract = {Additive manufacturing of (quasi−) solid-state (QSS) electrochemical energy storage devices (EES) highlights the significance of gel polymer electrolytes (GPEs) design. Creating well-bonded electrode-GPEs interfaces in the electrode percolative network via printing leads to large-scale production of customized EES with boosted electrochemical performance but has proven to be quite challenging. Herein, we report on a versatile, universal and scalable approach to engineer a controllable, seamless electrode-GPEs interface via free radical polymerization (FRP) triggered by MXene at room temperature. Importantly, MXene reduces the dissociation enthalpy of persulfate initiators and significantly shortens the induction period accelerated by SO 4 − , enabling the completion of FRP within minutes. The as-formed well-bonded electrode-GPEs interface homogenizes the electrical and concentration fields (i.e., Zn 2+ ), therefore suppressing the dendrites formation, which translates to long-term cycling (50,000 times), high energy density (105.5 Wh kg −1 ) and power density (9231 W kg −1 ) coupled with excellent stability upon deformation in the zinc-ion hybrid capacitors (ZHCs). Moreover, the critical switch of the rheological behaviours of the polymer electrolyte (as aqueous inks in still state and become solids once triggered by MXene) perfectly ensures the direct all-printing of electrodes and GPEs with well-bonded interface in between, opening vast possibilities for all-printed QSS EES beyond ZHCs.}, archive = {J_ANGEW}, author = {Wentao Zhang and Chuijin Zeng and Mengtian Zhang and Chendong Zhao and Dongliang Chao and Guangmin Zhou and Chuanfang Zhang}, doi = {10.1002/anie.202413728}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413728}, shortjournal = {Angew. Chem. Int. Edit.}, title = {MXene triggered free radical polymerization in minutes toward all-printed zn-ion hybrid capacitors and beyond}, volume = {64}, year = {2025}, }
• (2025). Strain-release-driven electrochemical skeletal rearrangement of non-biased alkyl Cyclopropanes/Butanes. ANGEW, 64(1), e202413723. (www)

  @article{ , abstract = {Capitalizing the inherent strain energy within molecules, strain-release-driven reactions have been widely employed in organic synthesis. Small cycloalkanes like cyclopropanes and cyclobutanes, with their moderate ring strain, typically require dense functionalization to induce bias or distal activation of (hetero) aromatic rings via single-electron oxidation for relieving the tension. In this study, we present a pioneering direct activation of alkyl cyclopropanes/butanes through electrochemical oxidation. This approach not only showcases the potential for ring-opening of cyclopropane/butane under electrochemical conditions but also streamlines the synthesis of diverse oxazolines and oxazines. The applicability of our method is exemplified by its broad substrate scopes. Notably, the products derived from cyclobutanes undergo a formal ring contraction to cyclopropanes, introducing an intriguing aspect to our discoveries. These discoveries mark a significant advancement in strain-release-driven skeletal rearrangement reactions of moderately strained rings, offering sustainable and efficient synthetic pathways for future endeavours.}, archive = {J_ANGEW}, author = {Jing Qi and Chu Wang and Gan Wang and Patrick O'Neill and Srinivas Reddy Dubbaka and Hwee Ting Ang and Xuebo Chen and Jie Wu}, doi = {10.1002/anie.202413723}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413723}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Strain-release-driven electrochemical skeletal rearrangement of non-biased alkyl Cyclopropanes/Butanes}, volume = {64}, year = {2025}, }
• (2025). Anti-swelling microporous membrane for high-capacity and long-life Zn−I2 batteries. ANGEW, 64(1), e202413703. (www)

  @article{ , abstract = {Zinc–iodine (Zn−I 2 ) batteries are gaining popularity due to cost-effectiveness and ease of manufacturing. However, challenges like polyiodide shuttle effect and Zn dendrite growth hinder their practical application. Here, we report a cation exchange membrane to simultaneously prevent the polyiodide shuttle effect and regulate Zn 2+ deposition. Comprised of rigid polymers, this membrane shows superior swelling resistance and ion selectivity compared to commercial Nafion. The resulting Zn−I 2 battery exhibits a high Coulombic efficiency of 99.4 % and low self-discharge rate of 4.47 % after 48 h rest. By directing a uniform Zn 2+ flux, the membrane promotes a homogeneous electric field, resulting in a dendrite-free Zn surface. Moreover, its microporous structure enables pre-adsorption of additional active materials prior to battery assembly, boosting battery capacity to 287 mAh g −1 at 0.1 A g −1 . At 2 A g −1 , the battery exhibits a steady running for 10,000 cycles with capacity retention up to 96.1 %, demonstrating high durability of the membrane. The practicality of the membrane is validated via a high-loading (35 mg cm −2 ) pouch cell with impressive cycling stability, paving a way for membrane design towards advanced Zn−I 2 batteries.}, archive = {J_ANGEW}, author = {Qianru Chen and Junnan Hao and Yilong Zhu and Shao-Jian Zhang and Peipei Zuo and Xun Zhao and Mietek Jaroniec and Shi-Zhang Qiao}, doi = {10.1002/anie.202413703}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413703}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anti-swelling microporous membrane for high-capacity and long-life Zn−I2 batteries}, volume = {64}, year = {2025}, }
• (2025). Oriented titanium-MOF membrane for hydrogen purification. ANGEW, 64(1), e202413701. (www)

  @article{ , abstract = {Precise hydrogen sorting from purge gas (H 2 /N 2 ) and coke gas (H 2 /CH 4 ), commonly carried out by cryogenic distillation, still suffers from low separation efficiency, high energy consumption, and considerable capital cost. Though still in its infancy, membrane technology offers a potential to achieve more efficient hydrogen purification. In this study, an optimum separation of hydrogen towards both methane and nitrogen via a kinetically-driven mechanism is realized through preferred orientation control of a MOF membrane. Relying on the 0.3 nm-sized window aligned vertical to the substrate, b -oriented Ti-MOF membrane exhibits ultra-high hydrogen selectivity, surpassing the upper bound limit of separating H 2 /N 2 and H 2 /CH 4 gas pairs attained so far by inorganic membranes. This spectacular selectivity is combined with a high H 2 permeability owing to the synergistic effect of the 1 nm-sized MOF channel.}, archive = {J_ANGEW}, author = {Sixing Chen and Mohammad Wahiduzzaman and Taotao Ji and Yi Liu and Yang Li and Chen Wang and Yanwei Sun and Gaohong He and Guillaume Maurin and Sujing Wang}, doi = {10.1002/anie.202413701}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413701}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Oriented titanium-MOF membrane for hydrogen purification}, volume = {64}, year = {2025}, }
• (2025). Anion exchange membrane water electrolysis at 10 a ⋅ cm−2 over 800 hours. ANGEW, 64(1), e202413698. (www)

  @article{ , abstract = {Anion exchange membrane water electrolyzer (AEMWE) is a potentially cost-effective technology for green hydrogen production. Although the normal current densities of AEMWEs are below 3 A ⋅ cm −2 , operating them at higher current densities represents an efficient, but little-explored approach to decrease the total cost of hydrogen production. We show here that a benchmark AEMWE has an operational lifetime of only seconds at an ultrahigh current density of 10 A ⋅ cm −2 . By using a more conductive and robust AEM, and judicious choices of ionomers, catalyst, and porous transport layer, we have developed AEMWEs that stably operate at 10 A ⋅ cm −2 with extended lifetimes. The optimized AEMWE has an operational lifetime of more than 800 hours, a 5-order magnetite improvement over the current benchmark. The cell voltage is only 2.3 V at 10 A ⋅ cm −2 , comparable to those of the state-of-the-art devices operating at current densities lower than 3 A ⋅ cm −2 . This work demonstrates the potential of ultrahigh current density AEMWEs.}, archive = {J_ANGEW}, author = {Yiwei Zheng and Wenchao Ma and Ariana Serban and Andrit Allushi and Xile Hu}, doi = {10.1002/anie.202413698}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413698}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Anion exchange membrane water electrolysis at 10 a ⋅ cm−2 over 800 hours}, volume = {64}, year = {2025}, }
• (2025). Sulfate derivatives with heteroleptic tetrahedra: New deep-ultraviolet birefringent materials in which weak interactions modulate functional module ordering. ANGEW, 64(1), e202413680. (www)

  @article{ , abstract = {Deep-ultraviolet (UV) birefringent materials are urgently needed to facilitate light polarization in deep-UV lithography. Maximizing anisotropy by regulating the alignment of functional modules is essential for improving the linear optical performance of birefringent materials. In this work, we proposed a strategy to design deep-UV birefringent materials that achieve functional module ordering via weak interactions. Following this strategy, four compounds CN 4 H 7 SO 3 CF 3 , CN 4 H 7 SO 3 CH 3 , C(NH 2 ) 3 SO 3 CH 3 , and C(NH 2 ) 3 SO 3 CF 3 were identified as high-performance candidates for deep-UV birefringent materials. The millimeter-sized crystals of CN 4 H 7 SO 3 CF 3 , CN 4 H 7 SO 3 CH 3 , and C(NH 2 ) 3 SO 3 CH 3 were grown, and the transmittance spectra show that their cutoff edges are below 200 nm. CN 4 H 7 SO 3 CF 3 exhibits the largest birefringence (0.149 @ 546 nm, 0.395 @ 200 nm) in the deep-UV region among reported sulfates and sulfate derivatives. It reveals that the hydrogen bond can modulate the module ordering of the heteroleptic tetrahedra and planar π-conjugated cations, thus greatly enhancing the birefringence. Our study not only discovers new deep-UV birefringent materials but also provides an upgraded strategy for optimizing optical anisotropy to achieve efficient birefringence.}, archive = {J_ANGEW}, author = {Huan Zhou and Meng Cheng and Dongdong Chu and Xu Liu and Ran An and Shilie Pan and Zhihua Yang}, doi = {10.1002/anie.202413680}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413680}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sulfate derivatives with heteroleptic tetrahedra: New deep-ultraviolet birefringent materials in which weak interactions modulate functional module ordering}, volume = {64}, year = {2025}, }
• (2025). Construction of chiral covalent organic frameworks through a linker decomposition chiral induction strategy for circularly polarized light detection. ANGEW, 64(1), e202413675. (www)

  @article{ , abstract = {Exploring new strategies for construction of chiral covalent organic frameworks (COFs) is of paramount importance yet remains a challenge. Herein, we report the rational design and construction of chiral COFs through a linker decomposition chiral induction (LDCI) strategy. Three pairs of azine-linked chiral COFs are successfully synthesized by the condensation reactions of C 3 -symmetric 4,4′,4′′-(1,3,5-triazine-2,4,6-triyl)tribenzaldehyde (Tz) with flexible chiral dihydrazide linkers derived from malic acid, aspartic acid and tartaric acid, respectively. Remarkably, upon complete or partial decomposition from flexible chiral dihydrazides to hydrazine during COF synthesis, the homochirality of these COFs, originating from the single-handedness conformation of propeller-like Tz cores, is well preserved. Such a stereoselective chiral memory realized via the LDCI strategy is confirmed by time-dependent powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR) and diffuse reflectance circular dichroism (DRCD). Moreover, the resultant azine-linked chiral COFs are used as the active materials to fabricate photodetectors to directly distinguish circularly polarized light (CPL), showing impressive recognition performances on the identification of left-handed circularly (LHC) and right-handed circularly (RHC) polarized lights. Notably, the residual undecomposed flexible chiral linkers within the COFs are found to be conducive to improving the polarization discrimination ratio. This work highlights LDCI as a new and effective strategy for constructing homochiral COFs with promising future in chiral optical application.}, archive = {J_ANGEW}, author = {Xihao Tang and Jiajia Zha and Xueying Wu and Jingyi Tong and Qianfeng Gu and Kai Zhang and Yuwei Zhang and Shengrun Zheng and Jun Fan and Weiguang Zhang and Qichun Zhang and Chaoliang Tan and Songliang Cai}, doi = {10.1002/anie.202413675}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413675}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Construction of chiral covalent organic frameworks through a linker decomposition chiral induction strategy for circularly polarized light detection}, volume = {64}, year = {2025}, }
• (2025). Molecular evidence for the axial coordination effect of atomic iodine on fe-n4 sites in oxygen reduction reaction. ANGEW, 64(1), e202413673. (www)

  @article{ , abstract = {We present a molecular-scale investigation of the axial coordination effect of atomic iodine on Fe-N 4 sites in the oxygen reduction reaction (ORR) by electrochemical scanning tunneling microscopy (ECSTM). A well-defined model catalytic system with explicit and uniform iodine-coordinated Fe-N 4 sites was constructed facilely by the self-assembly of iron(II) phthalocyanine (FePc) on an I-modified Au(111) surface. The electrocatalytic activity of FePc for the ORR shows notable enhancement with axial iodine ligands. The modulation of the electronic structure of Fe sites to evoke a higher spin configuration by axial iodine was evidenced. The interaction strength between oxygen-containing species and active centers becomes weaker due to the presence of iodine ligands, and the reaction is thermodynamically preferable. Furthermore, the reaction dynamics of FePc on I/Au(111) were explicitly determined via in situ ECSTM potential pulse experiments. In contrast, axial atomic iodine was found inefficacious for improving the activity of Co-N 4 sites, and electron rearrangement was found to be marginal, demonstrating that adequate interactions between axial ligands and metal sites for optimizing electronic structures and catalytic behaviors are prerequisites for the impactful role of axial ligands.}, archive = {J_ANGEW}, author = {Xiang Wang and Zhen-Yu Yi and Yu-Qi Wang and Dong Wang}, doi = {10.1002/anie.202413673}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413673}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular evidence for the axial coordination effect of atomic iodine on fe-n4 sites in oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Machine learning-guided discovery of Copper(I)-iodide cluster scintillators for efficient X-ray luminescence imaging. ANGEW, 64(1), e202413672. (www)

  @article{ , abstract = {Developing efficient scintillators with environmentally friendly compositions, adaptable band gaps, and robust chemical stability is crucial for modern X-ray radiography. While copper(I)-iodide cluster crystals show promise, the vast design space of inorganic cores and organic ligands poses challenges for conventional approaches. In this study, we present machine learning-guided discovery of copper(I)-iodide cluster scintillators for efficient X-ray luminescence imaging. Our findings reveal that combining base learning models with fused features enhances model generalization, achieving an impressive determination coefficient of 0.88. By leveraging this approach, we obtain a high-performance Cu(I)-I cluster scintillator, named copper iodide-(1-Butyl-1,4-diazabicyclo[2.2.2]octan-1-ium) 2 , which exhibit radioluminescence 56 times stronger than that of PbWO 4 , and enables a detection limit for X-rays of 19.6 nGy air s −1 . Furthermore, we demonstrate the versatility of these scintillators by incorporating them as microfillers in the fabrication of flexible composite scintillators for X-ray imaging, achieving a static resolution of 20 lp mm −1 and demonstrating promising performance for dynamic X-ray imaging.}, archive = {J_ANGEW}, author = {Yanze Wang and Tinghao Zhang and Wenjing Zhao and Weidong Xu and Zhongbin Wu and Yung Doug Suh and Yuezhou Zhang and Xiaowang Liu and Wei Huang}, doi = {10.1002/anie.202413672}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413672}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Machine learning-guided discovery of Copper(I)-iodide cluster scintillators for efficient X-ray luminescence imaging}, volume = {64}, year = {2025}, }
• (2025). Entropy-modulated short-chain cathode for low-temperature all-solid-state Li−S batteries. ANGEW, 64(1), e202413670. (www)

  @article{ , abstract = {All-solid-state Li−S batteries (ASSLSBs) due to high theoretical energy density and exceptional safety are highly desirable for electric aircraft. However, as the flight altitude rises, the low-temperature performance is hampered by inadequate practical capacity. Here, we discover that low-temperature sulfur utilization is constrained by the multi-step endothermic conversion reaction. By introducing multi-chalcogen to modulate the local entropy, a short-chain molecule cathode is designed to shorten the reduction pathways and enhance low-temperature discharge capacity. Furthermore, the mismatched lithiation lattice of the short-chain cathode reduces the decomposition energy barriers, thus enhancing low-temperature charge/discharge reversibility. The designed short-chain cathode exhibits high cathode utilization (99.4 %) and cycling stability (400 cycles, 92.2 % retention) at room temperature, as well as delivers excellent discharge capacity (579.6 mAh g −1 , −40 °C) and cycling performance (100 cycles, 98.4 % retention, 394.9 Wh kg − 1electrode, −20 °C) at low temperature. This study presents new opportunities to stimulate the development of low-temperature ASSLSBs.}, archive = {J_ANGEW}, author = {Wei Zhao and Yan Zhang and Qingsong Liu and Yajie Song and Xu Li and Liping Ren and Geping Yin and Shuaifeng Lou and Jiajun Wang}, doi = {10.1002/anie.202413670}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413670}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Entropy-modulated short-chain cathode for low-temperature all-solid-state Li−S batteries}, volume = {64}, year = {2025}, }
• (2025). Multi-enzyme mimetic MoCu dual-atom nanozyme triggering oxidative stress cascade amplification for high-efficiency synergistic cancer therapy. ANGEW, 64(1), e202413661. (www)

  @article{ , abstract = {Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and the overexpressed antioxidants in the tumor microenvironment restrict the amplification of tumor oxidative stress, resulting in unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) with various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) oxidase, and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared with Mo SAzyme, the introduction of Cu atoms, formation of dual-atom sites, and synergetic catalytic effects among various active sites enhance substrate adsorption and reduce the energy barrier, thereby endowing MoCu DAzyme with stronger catalytic activities. Benefiting from the above enzyme-like activities, MoCu DAzyme can not only generate multiple ROS, but also deplete GSH and block its regeneration to trigger the cascade amplification of oxidative stress. Additionally, the strong optical absorption in the near-infrared II bio-window endows MoCu DAzyme with remarkable photothermal conversion performance. Consequently, MoCu DAzyme achieves high-efficiency synergistic cancer treatment incorporating collaborative catalytic therapy and photothermal therapy. This work will advance the therapeutic applications of DAzymes and provide valuable insights for nanocatalytic cancer therapy.}, archive = {J_ANGEW}, author = {Ziyao Li and Binbin Ding and Jing Li and Hao Chen and Jiashi Zhang and Jia Tan and Xinyu Ma and Di Han and Ping'an Ma and Jun Lin}, doi = {10.1002/anie.202413661}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413661}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-enzyme mimetic MoCu dual-atom nanozyme triggering oxidative stress cascade amplification for high-efficiency synergistic cancer therapy}, volume = {64}, year = {2025}, }
• (2025). Atomically dispersed vanadium-induced ru-V dual active sites enable exceptional performance for acidic water oxidation. ANGEW, 64(1), e202413657. (www)

  @article{ , abstract = {Regulating the catalytic reaction pathway to essentially break the activity/stability trade-off that limits RuO 2 and thus achieves exceptional stability and activity for the acidic oxygen evolution reaction (OER) is important yet challenging. Herein, we propose a novel strategy of incorporating atomically dispersed V species, including O-bridged V dimers and V single atoms, into RuO 2 lattices to trigger direct O−O radical coupling to release O 2 without the generation of *OOH intermediates. V n −RuO 2 showed high activity with a low overpotential of 227 mV at 10 mA cm −2 and outstanding stability during a 1050 h test in acidic electrolyte. Operando spectroscopic studies and theoretical calculations revealed that compared with the V single atom-doping case, the introduction of the V dimer into RuO 2 further decreases the Ru-V atomic distance and weakens the adsorption strength of the *O intermediate to the active V site, which supports the more energetically favorable oxygen radical coupling mechanism (OCM). Furthermore, the highly asymmetric Ru−O−V local structure stabilizes the surface Ru active center by lowering the valence state and increasing the resistance against overoxidation, which result in outstanding stability. This study provides insight into ways of increasing the intrinsic catalytic activity and stability of RuO 2 by atomically dispersed species modification.}, archive = {J_ANGEW}, author = {Qing Qin and Zijian Li and Xuhao Zhao and Hongyan Zhao and Li Zhai and Min Gyu Kim and Jaephil Cho and Haeseong Jang and Shangguo Liu and Xien Liu}, doi = {10.1002/anie.202413657}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413657}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atomically dispersed vanadium-induced ru-V dual active sites enable exceptional performance for acidic water oxidation}, volume = {64}, year = {2025}, }
• (2025). Promotion of RNF168-mediated nucleosomal H2A ubiquitylation by structurally defined k63-polyubiquitylated linker histone h1. ANGEW, 64(1), e202413651. (www)

  @article{ , abstract = {The chemical synthesis of histones with homogeneous modifications is a powerful approach for quantitatively deciphering the functional crosstalk between different post-translational modifications (PTMs). In this study, we developed an expedient site-specific (poly)ubiquitylation strategy (CAEPL, Cysteine Aminoethylation coupled with Enzymatic Protein Ligation), which integrates the Cys-aminoethylation reaction with the process of ubiquitin-activating enzyme UBA1-assisted native chemical ligation. Using this strategy, we successfully prepared monoubiquitylated and K63-linked di- and tri-ubiquitylated linker histone H1.0 proteins, which were incorporated into individual chromatosomes. Quantitative biochemical analysis of different RNF168 constructs on H1 ubiquitylated chromatosomes with different ubiquitin chain lengths demonstrated that K63-linked polyubiquitylated H1.0 could directly stimulate RNF168 ubiquitylation activity by enhancing the affinity between RNF168 and the chromatosome. Subsequent cryo-EM structural analysis of the RNF168/UbcH5c–Ub/H1.0-K63-Ub 3 chromatosome complex revealed the potential recruitment orientation between RNF168 UDM1 domain and K63-linked ubiquitin chain on H1.0. Finally, we explored the impact of H1.0 ubiquitylation on RNF168 activity in the context of asymmetric H1.0–K63-Ub 3 di-nucleosome substrate, revealing a comparable stimulation effect of both the inter- and intra-nucleosomal crosstalk. Overall, our study highlights the significance of access to structurally defined polyubiquitylated H1.0 by the CAEPL strategy, enabling in-depth mechanistic investigations of in-trans PTM crosstalk between linker histone H1.0 and core histone H2A ubiquitylation.}, archive = {J_ANGEW}, author = {Qiang Shi and Zhiheng Deng and Liying Zhang and Zebin Tong and Jia-Bin Li and Guo-Chao Chu and Huasong Ai and Lei Liu}, doi = {10.1002/anie.202413651}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413651}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Promotion of RNF168-mediated nucleosomal H2A ubiquitylation by structurally defined k63-polyubiquitylated linker histone h1}, volume = {64}, year = {2025}, }
• (2025). Photoinduced pd-catalyzed direct sulfonylation of allylic C−H bonds. ANGEW, 64(1), e202413646. (www)

  @article{ , abstract = {Allylic sulfones are valuable motifs due to their medicinal and biological significance and their versatile chemical reactivities. While direct allylic C−H sulfonylation represents a straightforward and desirable approach, these methods are primarily restricted to terminal alkenes, leaving the engagement of the internal counterparts a formidable challenge. Herein we report a photocatalytic approach that accommodates both cyclic and acyclic internal alkenes with diverse substitution patterns and electronic properties. Importantly, the obtained allylic sulfones can be readily diversified into a wide range of products, thus enabling formal alkene transposition and all-carbon quaternary center formation through the sequential C−H functionalization.}, archive = {J_ANGEW}, author = {Kallol Mukherjee and Kelvin Pak Shing Cheung and Vladimir Gevorgyan}, doi = {10.1002/anie.202413646}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413646}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photoinduced pd-catalyzed direct sulfonylation of allylic C−H bonds}, volume = {64}, year = {2025}, }
• (2025). Selective activation of peptide-thioester precursors for templated native chemical ligations. ANGEW, 64(1), e202413644. (www)

  @article{ , abstract = {Chemical protein synthesis enables access to proteins that would otherwise be difficult or impossible to obtain with traditional means such as recombinant expression. Chemoselective ligations provide the ability to join peptide segments prepared by solid-phase peptide synthesis. While native chemical ligation (NCL) is widely used, it is limited by the need for C-terminal thioesters with suitable reaction kinetics, properly placed native Cys or thiolated derivatives, and peptide segment solubility at low mM concentrations. Moreover, repetitive purifications to isolate ligated products are often yield-sapping, hampering efficiency and progress. In this work, we demonstrate the use of C ontrolled A ctivation of P eptides for T emplated N CL (CAPTN). This traceless multi-segment templated NCL approach permits the one-pot synthesis of proteins by harnessing selective thioester activation and orthogonal conjugation chemistries to favor formation of the full-length ligated product while minimizing side reactions. Importantly, CAPTN provides kinetic enhancements allowing ligations at sterically hindered junctions and low peptide concentrations. Additionally, this one-pot approach removes the need for intermediate purification. We report the synthesis of two E. coli ribosomal subunits S16 and S17 enabled by the chemical tools described herein. We anticipate that CAPTN will expedite the synthesis of valuable proteins and expand on templated approaches for chemical protein synthesis.}, archive = {J_ANGEW}, author = {Paul Spaltenstein and Riley J. Giesler and Samuel R. Scherer and Patrick W. Erickson and Michael S. Kay}, doi = {10.1002/anie.202413644}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413644}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective activation of peptide-thioester precursors for templated native chemical ligations}, volume = {64}, year = {2025}, }
• (2025). Stereoregular Poly(Phenyl glycidyl ethers): In situ formation of a polyether stereocomplex from a racemic monomer mixture. ANGEW, 64(1), e202413643. (www)

  @article{ , abstract = {Polymer stereocomplex formation represents a promising research area as it can improve thermal and mechanical properties of co-crystallized polymer strands of opposite chirality. Polymers that form stereocomplexes commonly feature high stereoregularity and usually require sourcing from enantiopure monomer building blocks. Herein, we report the in situ polyether stereocomplex formation from racemic epoxide monomers, i.e., substituted methyl phenyl glycidyl ethers. The bio-renewable glycidyl ethers were explored in both enantio- and isoselective ring-opening polymerizations (ROPs), resulting in isotactic poly(phenyl glycidyl ether). While the enantioselective ROP selectively resolves a single enantiomeric, isotactic polyether stereoisomer ([ mm ] P ≥78 %), the isoselective ROP leads to the concurrent formation of both isotactic ( R )- and ( S )-poly(phenyl glycidyl ether) stereoisomers ([ mm ] P ≥92 %) and thus results directly in a stereoisomer blend, which forms a stereocomplex. This is one of only a few polymer stereocomplexes generated directly during polymerization from a racemic monomer mixture. Stereocomplexes of the different poly(phenyl glycidyl ether)s show an increase in melting temperature of up to 76 °C, relative to the enantiopure parent polymers. The position of the methyl group at the phenyl ring determines both stereocomplex formation and the thermal properties of the resulting materials.}, archive = {J_ANGEW}, author = {Sandra Schüttner and Yiye Lu and Holger Frey and Geoffrey W. Coates}, doi = {10.1002/anie.202413643}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413643}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereoregular Poly(Phenyl glycidyl ethers): In situ formation of a polyether stereocomplex from a racemic monomer mixture}, volume = {64}, year = {2025}, }
• (2025). The operando nature of isobutene adsorbed in zeolite H−SSZ−13 unraveled by machine learning potentials beyond DFT accuracy. ANGEW, 64(1), e202413637. (www)

  @article{ , abstract = {Unraveling the nature of adsorbed olefins in zeolites is crucial to understand numerous zeolite-catalyzed processes. A well-grounded theoretical description critically depends on both an accurate determination of the potential energy surface (PES) and a reliable account of entropic effects at operating conditions. Herein, we propose a transfer learning approach to perform random phase approximation (RPA) quality enhanced sampling molecular dynamics simulations, thereby approaching chemical accuracy on both the determination and exploration of the PES. The proposed methodology is used to investigate isobutene adsorption in H−SSZ−13 as prototypical system to estimate the relative stability of physisorbed olefins, carbenium ions and surface alkoxide species (SAS) in Brønsted-acidic zeolites. We show that the tert -butyl carbenium ion formation is highly endothermic and no entropic stabilization is observed compared to the physisorbed complex within H−SSZ−13. Hence, its predicted concentration and lifetime are negligible, making a direct experimental observation unlikely. Yet, it remains a shallow minimum on the free energy surface over the whole considered temperature range (273–873 K), being therefore a short-lived reaction intermediate rather than a transition state species.}, archive = {J_ANGEW}, author = {Massimo Bocus and Sander Vandenhaute and Veronique Van Speybroeck}, doi = {10.1002/anie.202413637}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413637}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The operando nature of isobutene adsorbed in zeolite H−SSZ−13 unraveled by machine learning potentials beyond DFT accuracy}, volume = {64}, year = {2025}, }
• (2025). Molecular photoswitching unlocks glucose oxidase for synergistically reinforcing fenton reactions for antitumor chemodynamic therapy. ANGEW, 64(1), e202413633. (www)

  @article{ , abstract = {We have developed a new type of nanoparticles with potent antitumor activity photoactivatable via the combination of molecular photoswitching of spiropyran (SP) and enzymatic reaction of glucose oxidase (GOx). As two key processes involved therein, Fe(III)-to-Fe(II) photoreduction in Fe(III) metal–organic frameworks (MOFs) brings about the release of free Fe 2+ /Fe 3+ while the photoswitching of SP to merocyanine (MC) unlocks the enzymatic activity of GOx that was pre-passivated by SP. The release of free Fe 3+ boosts its hydrolysis and therefore enables the acidification of microenvironment, which is further reinforced by one of the products of the GOx-mediated glucose oxidation reaction, gluconic acid (GlcA). Based on the generation of Fe 2+ and acidic milieu together with another product of the oxidation reaction, hydrogen peroxide (H 2 O 2 ), these two processes jointly present triple enabling factors for generating lethal hydroxyl radicals (⋅OH) species via Fenton reactions and therefore oxidative stress capable of inhibiting tumor. The antitumor potency of such nanoparticle is verified in tumor-bearing model mice in vivo, proclaiming its potential as a potent and safe agent based on the unique mechanism of optically manipulating enzyme activity for synergistic antitumor therapeutics with high spatial precision, enhanced efficacy and minimized side effects.}, archive = {J_ANGEW}, author = {Zicheng Wang and Weier Bao and Baerlike Wujieti and Ming Liu and Xiaojuan Li and Zhecheng Ma and Wei Cui and Zhiyuan Tian}, doi = {10.1002/anie.202413633}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413633}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular photoswitching unlocks glucose oxidase for synergistically reinforcing fenton reactions for antitumor chemodynamic therapy}, volume = {64}, year = {2025}, }
• (2025). Light- and temperature-controlled hybridization, chiral induction and handedness of helical foldamers. ANGEW, 64(1), e202413629. (www)

  @article{ , abstract = {Helical foldamers have attracted much attention over the last decades given their resemblance to certain biomacromolecules and their potential in domains as different as pharmaceutics, catalysis and photonics. Various research groups have successfully controlled the right- or left- handedness of these oligomers by introducing stereogenic centers through covalent or non-covalent chemistry. However, developing helical structures whose handedness can be reversibly switched remains a major challenge for chemists. To date, such an achievement has been reported with light-responsive single-stranded foldamers only. Herein, we demonstrate that grafting a unidirectional motor onto foldamer strands constitutes a relevant strategy to i) control the single or double helical state of a foldamer, ii) switch on the chiral induction process from the motor to the helical strands and iii) select the handedness of double helical structures through photochemical and thermal stimulations.}, archive = {J_ANGEW}, author = {Youssef Aidibi and Soussana Azar and Louis Hardoin and Marie Voltz and Sébastien Goeb and Magali Allain and Marc Sallé and Romain Costil and Denis Jacquemin and Ben Feringa and David Canevet}, doi = {10.1002/anie.202413629}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413629}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Light- and temperature-controlled hybridization, chiral induction and handedness of helical foldamers}, volume = {64}, year = {2025}, }
• (2025). Spontaneous formation of polymeric nanoribbons in water driven by π–π interactions. ANGEW, 64(1), e202413627. (www)

  @article{ , abstract = {A simple method was developed to produce polymeric nanoribbons and other nanostructures in water. This approach incorporates a perylene diimide (PDI) functionalized by triethylene glycol (TEG) as a hydrophobic supramolecular structure directing unit (SSDU) into the core of hydrophilic poly( N,N -dimethylacrylamide) (PDMAc) chains using RAFT polymerization. All PDI-functional polymers dissolved spontaneously in water, forming different nanostructures depending on the degree of polymerization ( DP n ): nanoribbons and nanocylinders for DP n =14 and 22, and spheres for DP n >50 as determined by cryo-TEM and SAXS analyses. UV/Vis absorption spectroscopy was used to monitor the evolution of the PDI absorption signal upon dissolution. In solid form, all polymers show a H-aggregate absorption signature, but upon dissolution in water, the shortest DP n forming nanoribbons evolved to show HJ-aggregate absorption signals. Over time, the J-aggregate band increased in intensity, while cryo-TEM monitoring evidenced an increase in the nanoribbon's width. Heating the nanoribbons above 60 °C, triggered a morphological transition from nanoribbons to nanocylinders, due to the disappearance of J-aggregates, while H-aggregates were maintained. The study shows that the TEG-PDI is a powerful SSDU to promote 2D or 1D self-assembly of polymers depending on DP n through simple dissolution in water.}, archive = {J_ANGEW}, author = {Sébastien Berruée and Jean-Michel Guigner and Thomas Bizien and Laurent Bouteiller and Lydia Sosa Vargas and Jutta Rieger}, doi = {10.1002/anie.202413627}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413627}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Spontaneous formation of polymeric nanoribbons in water driven by π–π interactions}, volume = {64}, year = {2025}, }
• (2025). Intermolecular anionic mixed-valence and π-dimer complexes of ortho-pentannulated bisazacoronene diimide. ANGEW, 64(1), e202413616. (www)

  @article{ , abstract = {This study reports the serendipitous discovery of intermolecular anionic mixed-valence (MV) and π-dimer species in ortho -pentannulated BisAzaCoroneneDiimides (BACDs) during their electrochemical reduction in a non-aqueous solvent. A library of nitrogen-containing extended PDIs was synthesized via an aza-benzannulation reaction followed by a Pd-catalysed ortho -pentannulation reaction. Ortho -pentannulated BACDs revealed strong aggregation abilities in solution. Concentration-dependent UV/Vis absorption spectra, variable temperature 1 H NMR experiments, and atomic force microscopy coupled to molecular dynamics support their self-assembly into columnar aggregates. Cyclic voltammetry experiments in dichloromethane reveal prominent splitting of the first reduction wave, attributed to the formation of unprecedented intermolecular anionic MV and π-dimers in organic solvent. These species were thoroughly characterized by real-time spectroelectrochemistry, electrochemical simulations and theoretical calculations. Remarkably, this work underscores the tuneable nature of AzaBenzannulatedPerylene Diimides (AzaBPDIs) and BACDs, emphasizing their potential as a promising scaffold for designing supramolecular materials with long-range radical anion delocalization. The observation of this phenomenon provides insights into the fundamental behaviour of supramolecular organic semiconductors, thereby paving the way for the development of novel electronic devices and electron-deficient materials.}, archive = {J_ANGEW}, author = {Arthur H. G. David and Maxime Roger and Olivier Alévêque and Heorhii Melnychenko and Laura Le Bras and Magali Allain and Adèle Gapin and David Canevet and Olivier Ségut and Eric Levillain and Antoine Goujon}, doi = {10.1002/anie.202413616}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413616}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Intermolecular anionic mixed-valence and π-dimer complexes of ortho-pentannulated bisazacoronene diimide}, volume = {64}, year = {2025}, }
• (2025). Electronic response and charge inversion at polarized gold electrode. ANGEW, 64(1), e202413614. (www)

  @article{ , abstract = {We have studied polarized Au(100) and Au(111) electrodes immersed in electrolyte solution by implementing finite-field methods in density functional theory-based molecular dynamics simulations. This allows us to directly compute the Helmholtz capacitance of electric double layer by including both electronic and ionic degrees of freedom, and the results turn out to be in excellent agreement with experiments. It is found that the electronic response of Au electrode makes a crucial contribution to the high Helmholtz capacitance and the instantaneous adsorption of Cl can lead to a charge inversion on the anodic polarized Au(100) surface. These findings point out ways to improve popular semi-classical models for simulating electrified solid–liquid interfaces and to identify the nature of surface charges therein which are difficult to access in experiments.}, archive = {J_ANGEW}, author = {Linnéa Andersson and Michiel Sprik and Jürg Hutter and Chao Zhang}, doi = {10.1002/anie.202413614}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413614}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic response and charge inversion at polarized gold electrode}, volume = {64}, year = {2025}, }
• (2025). Nonconventional fluorescent non-isocyanate polyurethane foams for multipurpose sensing applications. ANGEW, 64(1), e202413605. (www)

  @article{ , abstract = {Fluorescent foams with interconnected pores are attractive for the detection and quantification of various products. However, many fluorescent probes are suffering from aggregation-caused fluorescence quenching in their solid/aggregated state, are costly, and/or not straightforward to incorporate in foams, limiting their utility for this application. Herein, non-isocyanate polyurethane foams, prepared by the simple water-induced self-blowing process, present a nonconventional fluorescence behaviour, i.e. they are intrinsically fluorescent with a multicolor emission without requiring ex situ traditional fluorescent probes. These foams demonstrate utility for capturing-sensing gaseous formaldehyde (an emblematic indoor air pollutant), as well as for detecting and quantifying various metal ions (Fe 2+ , Cu 2+ , Fe 3+ , Hg 2+ ). They are also able to selectively sense tetracycline antibiotic in a ratiometric way with a high sensitivity. By exploiting the unique multicolor photoluminescent foam properties, a smartphone-compatible device is used for the facile antibiotic quantification. This nonconventional fluorescence behaviour is discussed experimentally and theoretically, and is mainly based on clusteroluminescence originating from multiple hydrogen bonding and hetero-atomic sub-luminophores, thus from aggregation-induced emission luminogens that are naturally present in the foams. This work illustrates that easily accessible non-conventional fluorescent NIPU foams characterized by a modular emission wavelength have an enormous potential for multiple substrates detection and quantification.}, archive = {J_ANGEW}, author = {Manas Mahapatra and Maxime Bourguignon and Bruno Grignard and Marylène Vandevenne and Moreno Galleni and Christophe Detrembleur}, doi = {10.1002/anie.202413605}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413605}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nonconventional fluorescent non-isocyanate polyurethane foams for multipurpose sensing applications}, volume = {64}, year = {2025}, }
• (2025). Asymmetric counteranion-directed electrocatalysis for enantioselective control of radical cation. ANGEW, 64(1), e202413601. (www)

  @article{ , abstract = {The control of enantioselectivity in radical cation reactions presents long-standing challenges, despite a few successful examples. We introduce a novel strategy of asymmetric counteranion-directed electrocatalysis to address enantioselectivity in radical cation chemistry. This concept has been successfully demonstrated in two reactions: an asymmetric dehydrogenative indole-phenol [3+2] coupling and an atroposelective C−H/N−H dehydrogenative coupling. These reactions have enabled the synthesis of benzofuroindolines and C−N axially chiral indoles with high yields and excellent enantiomeric excesses. Detailed mechanistic studies confirmed a radical-radical coupling mechanism. Moreover, density functional theory (DFT) calculations supported the indole radical cation as the pivotal intermediate, rather than a neutral indolyl radical, shedding new light on the underlying processes driving these reactions.}, archive = {J_ANGEW}, author = {Zhenhui Xu and Changdi Zheng and Jie Lin and Weiwei Huang and Dingguo Song and Weihui Zhong and Fei Ling}, doi = {10.1002/anie.202413601}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413601}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetric counteranion-directed electrocatalysis for enantioselective control of radical cation}, volume = {64}, year = {2025}, }
• (2025). The photodynamic agent designed by involvement of hydrogen atom transfer for enhancing photodynamic therapy. ANGEW, 64(1), e202413595. (www)

  @article{ , abstract = {Although Type-I photodynamic therapy has attracted increasingly growing interest due to its reduced dependence on oxygen, the design of effective Type-I photosensitizers remains a challenge. In this work, we report a design strategy for Type-I photosensitizers by the involvement of hydrogen atom transfer (HAT). As a proof of concept, a HAT-involved Type-I PS, which simultaneously generates superoxide and carbon-centered radicals under light-irradiation, was synthesized. This photosensitizer is comprised of a fluorene-substituted BODIPY unit as an electron acceptor covalently linked with a triphenylamine moiety as an electron donor. Under light-irradiation, photo-induced intramolecular electron transfer occurs to generate the BODIPY anion radical and triphenylamine cation radical. The former transfers electrons to oxygen to generate O 2 − ⋅, while the latter loses a proton to produce a benzyl carbon-centered radical which is well characterized. The resulting carbon-centered radicals efficiently oxidize NADH by HAT reaction. This photosensitizer demonstrates remarkable photocytotoxicity even under hypoxic conditions, along with outstanding in vivo antitumor efficacy in mouse models bearing HeLa tumors. This work offers a novel strategy for the design of Type-I photosensitizers by involvement of HAT.}, archive = {J_ANGEW}, author = {Zhuo Fan and Kun-Xu Teng and Yuan-Yuan Xu and Li-Ya Niu and Qing-Zheng Yang}, doi = {10.1002/anie.202413595}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413595}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The photodynamic agent designed by involvement of hydrogen atom transfer for enhancing photodynamic therapy}, volume = {64}, year = {2025}, }
• (2025). High-selectivity tandem photocatalytic methanation of CO2 by lacunary polyoxometalates-stabilized *CO intermediate. ANGEW, 64(1), e202413594. (www)

  @article{ , abstract = {Stabilizing specific intermediates to produce CH 4 remains a main challenge in solar-driven CO 2 reduction. Herein, g-C 3 N 4 is modified with saturated and lacunary phosphotungstates (PW x , x =12, 11, 9) to tailor the CO 2 reduction pathway to yield CH 4 in high selectivity. Increased lacuna of phosphotungstates leads to higher CH 4 yield and selectivity, with a superior CH 4 selectivity of 80 % and 40.8 μmol ⋅ g −1 ⋅ h −1 evolution rate for PW 9 /g-C 3 N 4 . Conversely, g-C 3 N 4 and PW x alone show negligible CH 4 production. The conversion of CO 2 to CH 4 follows a tandem catalytic process. CO 2 is initially activated on g-C 3 N 4 to form *CO intermediates, meanwhile photogenerated electrons derived from g-C 3 N 4 transfer to PW x . Then the reduced PW x captures *CO, which is subsquently hydrogenated to CH 4 . With the injection of two photogenerated electrons, PW 9 is capable of adsorbing and activating *CO. However, the reduced PW 12 and PW 11 are incapable of adsorbing *CO due to the small energy of occupied molecular orbitals, which is the reason for the poorer activity of PW x /g-C 3 N 4 ( x =12, 11) compared with that of PW 9 /g-C 3 N 4 . This work provides new insights to regulate highly selective CO 2 photoreduction to CH 4 by utilizing lacuna of polyoxometalates to enhance the interaction of metals in polyoxometalates with key intermediates.}, archive = {J_ANGEW}, author = {Qian Zhu and Zhaohui Li and Tao Zheng and Xingxing Zheng and Si Liu and Shen Gao and Xionghui Fu and Xiaofang Su and Yi Zhu and Yuanming Zhang and Yongge Wei}, doi = {10.1002/anie.202413594}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413594}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-selectivity tandem photocatalytic methanation of CO2 by lacunary polyoxometalates-stabilized *CO intermediate}, volume = {64}, year = {2025}, }
• (2025). Selective photocatalytic C−H oxidation of 5-methylcytosine in DNA. ANGEW, 64(1), e202413593. (www)

  @article{ , abstract = {Selective C−H activation on complex biological macromolecules is a key goal in the field of organic chemistry. It requires thermodynamically challenging chemical transformations to be delivered under mild, aqueous conditions. 5-Methylcytosine (5mC) is a fundamentally important epigenetic modification in DNA that has major implications for biology and has emerged as a vital biomarker. Selective functionalisation of 5mC would enable new chemical approaches to tag, detect and map DNA methylation to enhance the study and exploitation of this epigenetic feature. We demonstrate the first example of direct and selective chemical oxidation of 5mC to 5-formylcytosine (5fC) in DNA, employing a photocatalytic system. This transformation was used to selectively tag 5mC. We also provide proof-of-concept for deploying this chemistry for single-base resolution sequencing of 5mC and genetic bases adenine (A), cytosine (C), guanine (G), thymine (T) in DNA on a next-generation sequencing system. This work exemplifies how photocatalysis has the potential to transform the analysis of DNA.}, archive = {J_ANGEW}, author = {Tao Yan and Yuqi Chen and Ben Mortishire-Smith and Angela Simeone and Alexandre Hofer and Shankar Balasubramanian}, doi = {10.1002/anie.202413593}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413593}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective photocatalytic C−H oxidation of 5-methylcytosine in DNA}, volume = {64}, year = {2025}, }
• (2025). A-site engineering with thiophene-based ammonium for high-efficiency 2D/3D tin halide perovskite solar cells. ANGEW, 64(1), e202413584. (www)

  @article{ , abstract = {Tin halide perovskites are the most promising candidate materials for lead-free perovskite solar cells (PSCs) thanks to their low toxicity and ideal band gap energies. The introduction of 2D/3D mixed perovskite phases in tin-based PSCs (TPSCs) has proven to be the most effective approach to improving device efficiency and stability. However, a 2D perovskite phase normally shows relatively low carrier mobility, which will be unfavorable for carrier transfer in the devices. In this work, we used a thiophene-based cation 2-(thiophen-3-yl)ethan-1-aminium (3-TEA) as a spacer to form a novel 2D perovskite phase in TPSCs, which shows the most promising effect on the performance enhancement in comparison with other cations like 2-(thiophen-2-yl)ethan-1-aminium (2-TEA) and benzene-based 2-phenylethan-1-aminium (PEA). Theoretical calculations reveal that 3-TEA enables the most compact crystal packing of [SnI 6 ] 4− octahedral layers, resulting in the lowest hole effective mass and formation energy in the 2D phase. This effect significantly enhances device efficiency and stability by facilitating more efficient carrier transfer within the 2D phase. These findings indicate that thiophene-based 2D perovskites are well-suited for high-performance TPSCs.}, archive = {J_ANGEW}, author = {Guitao Feng and Hok-Leung Loi and Tianyue Wang and Wenqiu Deng and Zhiqiang Guan and Qi Wei and Jiandong He and Mingjie Li and Chun-Sing Lee and Jizheng Wang and Qichun Zhang and Feng Yan}, doi = {10.1002/anie.202413584}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413584}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A-site engineering with thiophene-based ammonium for high-efficiency 2D/3D tin halide perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Structurally compact Penta(N,N-diphenylamino)corannulene as dopant-free hole transport materials for stable and efficient perovskite solar cells. ANGEW, 64(1), e202413582. (www)

  @article{ , abstract = {Hole transport materials (HTMs) are essential for improving the stability and efficiency of perovskite solar cells (PSCs). In this study, we have designed and synthesized a novel organic small molecule HTM, cor-(DPA) 5 , characterized by a bowl-shaped core with symmetric five diphenylamine groups. Compared to already-known HTMs, the bowl-shaped and relatively compact structure of cor-(DPA) 5 facilitates intermolecular π–π interactions, promotes film formations, and enhances charge transport. Consequently, the cor-[DPA(2)] 5 HTM exhibits high charge mobility, exceptional hydrophobicity, and a significantly elevated glass transition temperature. Superior to previously reported HTMs such as spiro-OMeTAD and cor-OMePTPA , our newly synthesized cor-(DPA) 5 HTM is free from any ionic dopants. As a result, the dopant-free cor-[DPA(2)] 5 -based PSC demonstrates an impressive efficiency of 24.01 %, and exhibits outstanding operational stability. It retains 96 % after continuous exposure to 1 sun irradiation for 800 hours under MPP (maximum power point) tracking in ambient air. These findings present a structurally compact novel HTM and exemplify a new approach to the molecular design of HTM for the development of stable and effective PSCs.}, archive = {J_ANGEW}, author = {Xue-Peng Zhang and Luyao Wang and Wen-Xin Zhang and Zuo-Chang Chen and Chunming Yang and Si-Yi Xu and Peng Du and Bin-Wen Chen and Qunyang He and Han-Rui Tian and Xuejie Zhu and Meng Li and Shan-Shan Wang and Lin-Long Deng and Si-Hao Chen and Qianyan Zhang and Su-Yuan Xie and Lan-Sun Zheng}, doi = {10.1002/anie.202413582}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413582}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Structurally compact Penta(N,N-diphenylamino)corannulene as dopant-free hole transport materials for stable and efficient perovskite solar cells}, volume = {64}, year = {2025}, }
• (2025). Multimodal molecular motion in the rotaxanes and catenanes incorporating flexible calix[n]phyrin stations. ANGEW, 64(1), e202413579. (www)

  @article{ , abstract = {The synthesis of [2]rotaxanes stoppered with one or two dipyrromethane groups has opened a route for the construction of mechanically interlocked molecules incorporating various porphyrinoid stations. The exploitation of those precursors allowed the creation of [3]rotaxanes and [2]catenanes based on the calix[4]phyrin motif, presenting intriguing molecular dynamics. The intrinsic flexibility of the porphyrinoid allowed the introduction of a new type of molecular motion within the rotaxanes, termed fluttering. The latter involved a bending of the axle, interconverting two angular-shaped stereoisomers of the rotaxane through a planarised transition state. Simple chemical transformations, i.e. methylation and (de)protonation of the [3]rotaxane and [2]catenane allowed controllable transformations within the conformationally flexible calix[4]phyrin-incorporated mechanically interlocked porphyrinoids.}, archive = {J_ANGEW}, author = {Rafał A. Grzelczak and Tymoteusz Basak and Bartosz Trzaskowski and Vasyl Kinzhybalo and Bartosz Szyszko}, doi = {10.1002/anie.202413579}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413579}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multimodal molecular motion in the rotaxanes and catenanes incorporating flexible calix[n]phyrin stations}, volume = {64}, year = {2025}, }
• (2025). Effective alkyl-alkyl cross-coupling with an iron-xantphos catalyst: Mechanistic and structural insights. ANGEW, 64(1), e202413566. (www)

  @article{ , abstract = {While iron-catalyzed C(sp 2 )−C(sp 3 ) cross-couplings have been widely studied and developed in the last decade, alkyl-alkyl cross-coupling systems with iron remain underdeveloped despite the importance of C(sp 3 )−C(sp 3 ) bonds in organic synthesis. A major challenge to the development of these reactions is the current lack of fundamental insight into ligand effects and organoiron intermediates that enable effective alkyl-alkyl couplings. The current study addresses this longstanding limitation using a combination of 57 Fe Mössbauer spectroscopy, SC-XRD (single-crystal X-ray diffraction) and reactivity studies of alkyl-alkyl coupling with iron-Xantphos to define the in situ formed iron-Xantphos intermediates in catalysis. Combined with detailed reactivity studies, the nature of the key mechanistic pathways in catalysis and ligands effects to achieve effective alkyl-alkyl cross-coupling over competing β-H elimination pathways are probed. Overall, these foundational studies provide a platform for future bespoke ligand and pre-catalyst design for alkyl-alkyl cross-coupling methods development with sustainable iron catalysis.}, archive = {J_ANGEW}, author = {Magali Gimeno and Maria Camila Aguilera and Valerie E. Fleischauer and William W. Brennessel and Michael L. Neidig}, doi = {10.1002/anie.202413566}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413566}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Effective alkyl-alkyl cross-coupling with an iron-xantphos catalyst: Mechanistic and structural insights}, volume = {64}, year = {2025}, }
• (2025). Constructing targeted strong Nb4d−O2p−Li2s configurations to obtain excellent energy density and long life for li-rich cathodes. ANGEW, 64(1), e202413563. (www)

  @article{ , abstract = {The Li-rich Mn-based cathode materials (LMRs) deliver excellent energy density and exhibit low cost, which are considered as the most promising cathode materials for the next generation lithium-ion batteries. However, the irreversible redox reaction of the oxygen atoms directly leads to release oxygen and intensifies phase transformation. Besides, the local stress and strain will be generated due to the unit-cell volume difference between R-3m and C2/m phases, which continuously aggravates the collapse of secondary particles. Herein, the strong Nb 4d −O 2p −Li 2s configurations at the Li 1 sites of the TM-layer in the C2/m phase and secondary particles with the radial arrangement of refined primary particles are designed to inhibit oxygen release and relieve lattice stress by Nb 2 O 5 treatment. Meanwhile, the preferential growth of the active {010} planes is presented to obtain an excellent transmission rate of Li + . As a result, the designed LMR delivers remarkable electrochemical properties with high discharge capacity and initial coulomb efficiency of 276 mAh g −1 and 85 % at 0.1 C, outstanding cycling retention rate of 81 % after 300 cycles. This novel crystal structure combining oxygen coordination regulation and micro-nano scale design provides inspiration for the design of high-performance LMRs.}, archive = {J_ANGEW}, author = {Kanghui Hu and Huoqiang Tang and Baoping Zheng and Lei Yu and Feng Xiong and Haoyu Li and Lang Qiu and Fang Wan and Yang Song and Benhe Zhong and Zhenguo Wu and Xiaodong Guo}, doi = {10.1002/anie.202413563}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413563}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Constructing targeted strong Nb4d−O2p−Li2s configurations to obtain excellent energy density and long life for li-rich cathodes}, volume = {64}, year = {2025}, }
• (2025). Mechanochromic displays based on photoswitchable cholesteric liquid crystal elastomers. ANGEW, 64(1), e202413559. (www)

  @article{ , abstract = {Stimuli responsive optical materials are attractive for many areas, from healthcare to art design. However, creating intricate color-changing patterns for visual information is still a challenge. This work describes the preparation of mechanochromic structural colored intricate pictures imprinted in cholesteric liquid crystal elastomers by using a chiral isosorbide molecular photoswitch. The photoswitch contains a photoisomerizable cinnamate moiety and was incorporated in a main chain liquid crystal oligomer with photopolymerizable acrylate end groups. After coating, the structural colored film was irradiated with ultraviolet (UV) light in air causing E/Z isomerization of the cinnamate units leading to a redshift of the structural color of the film. A grayscale photomask was used to spatially control the photoisomerization reaction and imprint colorful pictures such as portraits and landscapes, in the cholesteric liquid crystal films with high resolution. Photopolymerization in a nitrogen atmosphere led to a mechanochromic cholesteric liquid crystal elastomer with striking structural colors that blueshift upon strain. The sharp details of the patterns were preserved even under deformation and the system returned to the initial state upon strain removal. Our work offers a simple photoswitch approach to prepare stimuli responsive optical polymers imprinted with color-changing pictures of unprecedented complexity.}, archive = {J_ANGEW}, author = {Lucas D. C. de Castro and Johan Lub and Osvaldo N. Oliveira and Albert P. H. J. Schenning}, doi = {10.1002/anie.202413559}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413559}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Mechanochromic displays based on photoswitchable cholesteric liquid crystal elastomers}, volume = {64}, year = {2025}, }
• (2025). Stereoselective vinylic C−H addition via metallaphotoredox migration. ANGEW, 64(1), e202413557. (www)

  @article{ , abstract = {Geometrically defined allylic alcohols with SE, SZ, RE and RZ stereoisomers serve as valuable intermediates in synthetic chemistry, attributed to the stereoselective transformations enabled by the alkenyl and hydroxyl functionalities. When an ideal scenario presents itself with four distinct stereoisomers as potential products, the simultaneous control vicinal stereochemistry in a single step would offer a direct pathway to any desired stereoisomer. Here, we unveil a metallaphotoredox migration strategy to access stereodefined allylic alcohols through vinylic C−H activation with aldehydes. This method harnesses a chiral nickel catalyst in concert with a photocatalyst to enable a 1,4-Ni migration by using readily accessible 2-vinyl iodoarenes as starting materials. The efficacy of this methodology is highlighted by the precise construction of all stereoisomers of allylic alcohols bearing analogous substituents and the efficient synthesis of key intermediates en route to Myristinin family. Experimental and computational studies have shed light on pivotal aspects including the synergy of metal catalysis and photocatalysis, the driving forces behind the migration, and the determination of absolute configuration in the C−H addition process.}, archive = {J_ANGEW}, author = {Linlin Ding and Minyan Wang and Yiming Liu and Hongjian Lu and Yue Zhao and Zhuangzhi Shi}, doi = {10.1002/anie.202413557}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413557}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Stereoselective vinylic C−H addition via metallaphotoredox migration}, volume = {64}, year = {2025}, }
• (2025). Inhibiting ion migration and stabilizing crystal-phase in halide perovskite via directly incorporated fluoride anion. ANGEW, 64(1), e202413550. (www)

  @article{ , abstract = {Fluoride anion (F − ) with extremely high electronegativity has been under intensive investigation in perovskite solar cells due to its remarkable defect suppression and great improvement of device performance. Nevertheless, these researches only focus on the surface, grain boundaries, or interface modification, the direct insertion of F − into the crystal lattice of regular lead halide perovskite films is still unrevealed. Herein, F − was successfully incorporated into the perovskite lattice by overcoming the insolubility of PbF 2 via the introduced pyridinium halide as a novel volatile solubilizing ligand. The strong electronegativity of F − can strongly increase the binding energy of all the ions in CsPbI 2 Br and inhibit their defect formations. A trace amount of F − incorporation not only enhanced the optoelectronic properties but also effectively mitigated the ion migration and phase separation simultaneously. The photovoltaic performance and operational stability of perovskite solar cells were significantly improved with a champion efficiency of 17.78 % (38.01 %) under AM 1.5G (1000 lux indoor light). Moreover, F − can also be directly inserted into the hybrid perovskite lattice and greatly stabilized crystal-phase, enabling efficient fully MA-free FAPbI 3 devices with 25.10 % efficiency. Our strategy sheds light on F-containing perovskites and provides a promising way to tackle ion migration and stabilize the crystal phase in halide perovskites.}, archive = {J_ANGEW}, author = {Boyao Zhang and Zhaosheng Hu and Jie Su and Zhen Gong and Xing Guo and Xiaoqing Chen and Yingguo Yang and Zhenhua Lin and Liming Ding and Yue Hao and Jingjing Chang}, doi = {10.1002/anie.202413550}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413550}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Inhibiting ion migration and stabilizing crystal-phase in halide perovskite via directly incorporated fluoride anion}, volume = {64}, year = {2025}, }
• (2025). Gold coordination-accelerated multi-resonance TADF emission for efficient solution-processible ultrapure deep-blue OLEDs. ANGEW, 64(1), e202413536. (www)

  @article{ , abstract = {Multi-resonance (MR) type emitters have emerged as highly promising candidates for high-resolution organic light-emitting diodes (OLEDs). However, thermally activated delayed fluorescence (TADF) emissions with simultaneous short excited state lifetimes and ultrapure blue color (a CIE y close to 0.046 and an emission peak >440 nm) have rarely been obtained for MR emitters. Herein, we report a design of dual gold-coordinated MR molecules to achieve efficient and short-lived ultrapure blue TADF emission. The dinuclear Au(I) complex, namely iPrAuBN , shows a narrowband deep-blue emission with a peak maximum of 448 nm and a full width at half maximum (FWHM) of 29 nm in doped film. The coordination with two Au atoms significantly shortens the delayed fluorescence lifetime to 7.8 μs in comparison to 60.6 μs for the parental organic analogue. Solution-processed OLED doped with iPrAuBN demonstrates an ultrapure blue electroluminescence with a peak maximum of 442 nm, a FWHM of 19 nm, CIE coordinates of (0.154, 0.036), and a maximum external quantum efficiency of 14.8 %.}, archive = {J_ANGEW}, author = {Xiu-Fang Song and Sai Luo and Nengquan Li and Xintong Wan and Jingsheng Miao and Yang Zou and Kai Li and Chuluo Yang}, doi = {10.1002/anie.202413536}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413536}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Gold coordination-accelerated multi-resonance TADF emission for efficient solution-processible ultrapure deep-blue OLEDs}, volume = {64}, year = {2025}, }
• (2025). Rectifying heterointerface facilitated C−N coupling dynamics enables efficient urea electrosynthesis under ultralow potentials. ANGEW, 64(1), e202413534. (www)

  @article{ , abstract = {Electrocatalytic C−N coupling for urea synthesis from carbon dioxide (CO 2 ) and nitrate (NO 3 − ) offers a sustainable alternative to the traditional Bosch-Meiser method. However, the complexity of intermediates in co-reduction hampers simultaneous improvement in urea yield and Faradaic efficiency (FE). Herein, we developed a Cu/Cu 2 O Mott–Schottky catalyst with nanoscale rectifying heterointerfaces through precise controllable in situ electroreduction of Cu 2 O nanowires, achieving notable FE (32.6–47.0 %) and substantial yields (6.08–30.4 μmol h −1 cm −2 ) across a broad range of ultralow applied potentials (0 to −0.3 V vs. RHE). Operando synchrotron radiation-Fourier transform infrared spectroscopy (SR-FTIR) confirmed the formation of *CO intermediates and C−N bonds, subsequently density functional theory (DFT) calculations deciphered that the Cu/Cu 2 O rectifying heterointerface modulated *CO adsorption, significantly enhancing subsequent C−N coupling dynamics between *CO and *NOH intermediates. This work not only provides a groundbreaking and advanced pathway for C−N coupling, but also offers deep insights into copper-based heterointerface catalysts for urea synthesis.}, archive = {J_ANGEW}, author = {Mingyu Cheng and Shao Wang and Zechuan Dai and Jing Xia and Bocheng Zhang and Pingyi Feng and Yin Zhu and Yangyang Zhang and Genqiang Zhang}, doi = {10.1002/anie.202413534}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413534}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rectifying heterointerface facilitated C−N coupling dynamics enables efficient urea electrosynthesis under ultralow potentials}, volume = {64}, year = {2025}, }
• (2025). Quantification of synergistic two-color covalent bond formation. ANGEW, 64(1), e202413530. (www)

  @article{ , abstract = {The emergence of highly wavelength resolved reactivity information for complex photochemical reaction processes allows the establishment of multi-color reaction modes. One particularly powerful mode is the synergistic two-color reaction, where two colors of light have to be present in the same volume element to either enable or enhance photochemical reactivity that leads to a specific photoproduct. Herein, we introduce a two-color synergistic photochemical reaction system based on a diaryl indenone epoxide (DIO) photoswitch and the cis -to- trans isomerization of a bridged ring-strained azobenzene (SA), which respond to ultraviolet (365 nm) and visible light (430 nm), respectively, with different rates, forming a well-defined heterocyclic photoadduct, DIOSA, that we structurally confirm via single crystal x-ray diffraction (SXRD). To quantitatively capture the effectiveness of the dual-color irradiation as a function of the reaction conditions such as light intensity and starting material ratio as a function of product yield, we introduce a parameter, the photochemical synergistic ratio . A reduced termed —that extrapolates to conditions of infinitesimal conversions—allows to compare the efficiency of the synergistic photochemistry at varying reaction conditions.}, archive = {J_ANGEW}, author = {Jan Hobich and Florian Feist and Phillip Werner and Joshua A. Carroll and Olaf Fuhr and Eva Blasco and Hatice Mutlu and Christopher Barner-Kowollik}, doi = {10.1002/anie.202413530}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413530}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Quantification of synergistic two-color covalent bond formation}, volume = {64}, year = {2025}, }
• (2025). Polyanionic receptors for carboxylates in water. ANGEW, 64(1), e202413505. (www)

  @article{ , abstract = {Receptors for carboxylate anions have many possible biomedical applications, including mimicry of the vancomycin group of antibiotics. However, binding carboxylates in water, the biological solvent, is highly challenging due to the hydrophilicity of these polar anions. Here we report, for the first time, the recognition of simple carboxylates such as acetate and formate in water by synthetic receptors with charge-neutral binding sites. The receptors are solubilised by polyanionic side-chains which, remarkably, do not preclude anion binding. The tricyclic structures feature two identical binding sites linked by polyaromatic bridges, capable of folding into closed, twisted conformations. This folding is hypothesised to preorganise the structures for anion recognition, mimicking the process which generates many protein binding sites. The architecture is suitable for elaboration into enclosed structures with potential for selective recognition of biologically relevant carboxylates.}, archive = {J_ANGEW}, author = {Xudong Ren and Alister J. Flint and Daniel Austin and Anthony P. Davis}, doi = {10.1002/anie.202413505}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413505}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyanionic receptors for carboxylates in water}, volume = {64}, year = {2025}, }
• (2025). Platinum-catalyzed regio- and enantioselective diboration of unactivated alkenes with (pin)B−B(dan). ANGEW, 64(1), e202413504. (www)

  @article{ , abstract = {Asymmetric diboration of terminal alkenes is well established, and subsequent selective functionalization of the less hindered primary boronic ester is commonly achieved. Conversely, selective functionalization of the sterically less accessible secondary boronic ester remains challenging. An alternative way to control chemoselective functionalization of bis(boron) compounds is by engendering different Lewis acidity to the two boryl moieties, since reactivity would then be dictated by Lewis acidity instead of sterics. We report herein the regio- and enantioselective Pt-catalyzed diboration of unactivated alkenes with (pin)B−B(dan). A broad range of terminal and cyclic alkenes undergo diboration to furnish the differentiable 1,2-bis(boron) compounds with high levels of regio- and enantiocontrol, giving access to a wide variety of novel building blocks from a common intermediate. The reaction places the less Lewis acidic B(dan) group at the less hindered position and the resulting 1,2-bisboryl alkanes undergo selective transformations of the B(pin) group located at the more hindered position. The regioselectivity of the diboration has been studied by DFT calculations and is believed to originate from the trans influence, which lowers the activation barrier for formation of the regioisomer that places the weaker electron donor [B(pin) vs B(dan)] opposite the strong electron donor (alkyl group) in the platinum complex.}, archive = {J_ANGEW}, author = {Huaquan Fang and Niket Manoj and Mihai V. Popescu and Adam Noble and Robert S. Paton and Varinder K. Aggarwal}, doi = {10.1002/anie.202413504}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413504}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Platinum-catalyzed regio- and enantioselective diboration of unactivated alkenes with (pin)B−B(dan)}, volume = {64}, year = {2025}, }
• (2025). Long-life all-solid-state batteries enabled by cold-pressed garnet composite electrolytes with enhanced li+ conduction. ANGEW, 64(1), e202413502. (www)

  @article{ , abstract = {Garnet Li 7 La 3 Zr 2 O 12 (LLZO)-based solid-state electrolytes (SSEs) hold promise for realizing next-generation lithium metal batteries with high energy density. However, the high stiffness of high-temperature sintered LLZO makes it brittle and susceptible to strain during the fabrication of solid-state batteries. Cold-pressed LLZO exhibits improved ductility but suffers from insufficient Li + conductivity. Here, we report cold-pressed Ta-doped LLZO (Ta−LZ) particles integrated with ductile Li 6 PS 5 Cl (LPSC) via a Li + conductive Li-containing Ta−Cl structure. This configuration creates a continuous Li + conduction network by enhancing the Li + exchange at the Ta−LZ/LPSC interface. The resulting Ta−LZ/LPSC SSE exhibits Li + conductivity of 4.42×10 −4 S cm −1 and a low activation energy of 0.31 eV. Li symmetric cells with Ta−LZ/LPSC SSE demonstrate excellent Li dendrite suppression ability, with an improved critical current density of 5.0 mA cm −2 and a prolonged cycle life exceeding 600 h at 1 mA cm −2 . Our finding provides valuable insights into developing cold-pressed ceramic powder electrolytes for high-performance all-solid-state batteries.}, archive = {J_ANGEW}, author = {Bing-Qing Xiong and Jianwei Zhang and Qingshun Nian and Xiaoye Liu and Jinyu Jiang and Zihong Wang and Zhenzhong Yang and Xiaodi Ren}, doi = {10.1002/anie.202413502}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413502}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Long-life all-solid-state batteries enabled by cold-pressed garnet composite electrolytes with enhanced li+ conduction}, volume = {64}, year = {2025}, }
• (2025). Chalcogen bonds enable efficient photoreduction of sulfur-containing heterocycles. ANGEW, 64(1), e202413498. (www)

  @article{ , abstract = {Chalcogen bonding interactions have attracted significant attention in a broad chemistry community, with a particular focus on their ability to stabilise the key transition states in various organic synthetic routes. In this work, we demonstrate that they can also be harnessed in selective photoredox reactions, which cannot be otherwise achieved with alternative approaches to photoreduction. We demonstrate this concept through the photoreduction of the sulfur-containing DNA nucleoside precursor thioanhydrouridine to 2’-deoxy-thiouridine, revealing the previously unrecognized role of bisulfide in this process. Based on quantum chemical simulations, we identify a stable chalcogen-bonding complex of the hydrosulfide anion and thionhydrouridine (HS − ⋅⋅⋅S contacts), which enables directional photoinduced electron transfer, resulting in the formation of non-canonical DNA nucleoside. We also disprove the possibility that photoreduction of thioanhydronucleosides could be initiated by hydrated electrons generated from irradiated bisulfide anions which do not interact with the chromophore. Finally, we show that selective photoreduction mediated by chalcogen bonds can only occur for chromophores, which exhibit sufficiently long excited-state lifetimes in the locally-excited states to undergo transition to the productive charge transfer state. These findings can be further used in the design of similar photoredox reactions which can employ the potential of chalcogen bonding interactions.}, archive = {J_ANGEW}, author = {Mikołaj J. Janicki and Rafał Szabla}, doi = {10.1002/anie.202413498}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413498}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Chalcogen bonds enable efficient photoreduction of sulfur-containing heterocycles}, volume = {64}, year = {2025}, }
• (2025). Evaluation of active oxygen species derived from water splitting for electrocatalytic organic oxidation. ANGEW, 64(1), e202413457. (www)

  @article{ , abstract = {Active oxygen species (OH*/O*) derived from water electrolysis are essential for the electrooxidation of organic compounds into high-value chemicals, which can determine activity and selectivity, whereas the relationship between them remains unclear. Herein, using glycerol (GLY) electrooxidation as a model reaction, we systematically investigated the relationship between GLY oxidation activity and the formation energy of OH* (Δ G OH* ). We first identified that OH* on Au demonstrates the highest activity for GLY electrooxidation among various pure metals, based on experiments and density functional theory, and revealed that Δ G OH* on Au-based alloys is influenced by the metallic composition of OH* coordination sites. Moreover, we observed a linear correlation between the adsorption energy of GLY ( E ads ) and the d -band center of Au-based alloys. Comprehensive microkinetic analysis further reveals a volcano relationship between GLY oxidation activity, the Δ G OH* and the adsorption free energy of GLY (Δ G ads ). Notably, Au 3 Pd and Au 3 Ag alloys, positioned near the peak of the volcano plot, show excellent activity, attributed to their moderate Δ G OH* and Δ G ads , striking a balance that is neither too high nor too low. This research provides theoretical insights into modulating active oxygen species from water electrolysis to enhance organic electrooxidation reactions.}, archive = {J_ANGEW}, author = {Jiangrong Yang and Tian Xia and Hao Li and Hong Yan and Xianggui Kong and Zhenhua Li and Mingfei Shao and Xue Duan}, doi = {10.1002/anie.202413457}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413457}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Evaluation of active oxygen species derived from water splitting for electrocatalytic organic oxidation}, volume = {64}, year = {2025}, }
• (2025). Organometallic polymer constructed by active Fe−C12N8 centers for boosting sodium-ion storage. ANGEW, 64(1), e202413452. (www)

  @article{ , abstract = {Organic-metal coordination materials with rich structural diversity are considered as promising electrode materials for rechargeable sodium-ion batteries. However, the electrochemical performance can be constrained by the limited number of active sites and structural instability under the discharge/charge process. Herein, organometallic polymer microspheres (Fe-PDA-220) with a unique d-π conjugated structure was designed and successfully constructed through a simple synchronous polymerization and coordination reactions. Polymerization of phenylenediamine was initiated by Fe 3+ and Fe 2+ ions generated synchronously during the polymerization integrated with poly-aminoquinone chains to form Fe−C 12 N 8 active centers. Used as electrode materials for sodium-ion batteries, the distinctive Fe−C bond significantly boosts the structural stability, and the π-d conjugation system could facilitate electron transfer. A high reversible capacity of 345 mAh g −1 was delivered at 0.1 A g −1 and a capacity of 106 mAh g −1 was maintained even after discharged/charged at 1.0 A g −1 for 5000 cycles, outperforming most reported coordination materials. Spectroscopic and electronic analyses revealed that a two-electron reaction occurred per active unit, accompanied by the reversible redox evolution of the C=N groups and Fe ions during the sodiation/desodiation. This work provides a promising and efficient strategy for boosting the electrochemical performance of organic electrode materials by the design of organometallic polymers.}, archive = {J_ANGEW}, author = {Liang-Yu Wang and Chao Ma and Jia-Ning Yang and Kai-Xue Wang and Jie-Sheng Chen}, doi = {10.1002/anie.202413452}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413452}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organometallic polymer constructed by active Fe−C12N8 centers for boosting sodium-ion storage}, volume = {64}, year = {2025}, }
• (2025). Lanthanide-like contraction enables the fabrication of high-purity selenium films for efficient indoor photovoltaics. ANGEW, 64(1), e202413429. (www)

  @article{ , abstract = {The lanthanide contraction involves a reduction in atomic radius among f-block elements below the expected level. A similar contraction is observed in group-16 elements. The atomic radius of Se (117 pm) is slightly larger than that of S (104 pm) arising from the presence of d electrons, compared to the significant increase in atomic radius from O (73 pm) to S. This lanthanide-like contraction contributes to Se's robust oxidative resistance. Here we report a selective oxidation strategy utilizing Se's strong antioxidative property to remove coexisting narrow-band gap Te impurities from Se feedstocks. This strategy selectively oxidizes volatile Te impurities into involatile TeO 2 that remains in the evaporation source, while only volatile Se deposits onto the substrate during the thermal-evaporation deposition process. This enables the fabrication of high-purity Se films possessing a wide band gap of 1.88 eV, ideally suited to the optimal band gap for indoor photovoltaics (IPVs). The resulting Se photovoltaics exhibit an efficiency of 20.1 % under 1000-lux indoor illumination, outperforming market-dominant amorphous silicon and all types of lead-free perovskite IPVs. Unencapsulated Se devices show no efficiency degradation after 20,000 hours of storage in ambient atmosphere.}, archive = {J_ANGEW}, author = {Wenbo Lu and Zongbao Li and Mingjie Feng and Jinchao Wei and Xin Wen and Xiaoyan An and Zhouqing Wei and Yuan Lin and Jin-Song Hu and Ding-Jiang Xue}, doi = {10.1002/anie.202413429}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413429}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lanthanide-like contraction enables the fabrication of high-purity selenium films for efficient indoor photovoltaics}, volume = {64}, year = {2025}, }
• (2025). Diastereoselective and enantioselective hydrophosphinylations of conjugated enynes, allenes and dienes via synergistic Pd/Co catalysis. ANGEW, 64(1), e202413428. (www)

  @article{ , abstract = {Different from the reported work focusing on the construction of single P - or C -stereocenter via hydrophosphinylation of unsaturated carbon bonds, the highly diastereo- and enantioselective hydrophosphinylation reaction of allenes, conjugated enynes and 1,3-dienes is achieved via a designed Pd/Co dual catalysis and newly modified masked phosphinylating reagent. A series of allyl motifs bearing both a tertiary C - and P -stereocenter are prepared in generally good yields, >20 : 1 dr, >20 : 1 rr and 99 % ee. The unprecedented diastereo- and enantioselective hydrophosphinylation of 1,3-enynes is established to generate skeletons containing both a P -stereocenter and a nonadjacent chiral axis. The first stereodivergent hydrophosphinylation reaction is also developed to achieve all four P -containing stereoisomers. The present protocol features the use of only 3-minutes reaction time and 0.1 % catalyst, and with the observation of up to 730 TON. A set of mechanistic studies reveal the necessity and roles of two metal catalysts and corroborate the designed synergistic process.}, archive = {J_ANGEW}, author = {Ming-Qiao Tang and Zi-Jiang Yang and Ai-Jun Han and Zhi-Tao He}, doi = {10.1002/anie.202413428}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413428}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Diastereoselective and enantioselective hydrophosphinylations of conjugated enynes, allenes and dienes via synergistic Pd/Co catalysis}, volume = {64}, year = {2025}, }
• (2025). Experimental and theoretical characterization of 4π-electron möbius aromatic system of a 1,2-digermacyclobutadiene†. ANGEW, 64(1), e202413426. (www)

  @article{ , abstract = {We present the visualization of the experimental valence electron-density distribution (EDD) in the isolated 1,2-digermacyclobutadiene ring system, revealing the unique 4π electron-delocalization on the four-membered Ge 2 C 2 ring. A remarkably high Möbius 4π-electron aromatic character in the Ge 2 C 2 ring can be suggested from theoretical calculations, in sharp contrast to the significant antiaromaticity of the all-carbon cyclobutadiene ring.}, archive = {J_ANGEW}, author = {Tomohiro Sugahara and Daisuke Hashizume and Arturo Espinosa Ferao and Koichiro Masada and Norihiro Tokitoh and Takahiro Sasamori}, doi = {10.1002/anie.202413426}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413426}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Experimental and theoretical characterization of 4π-electron möbius aromatic system of a 1,2-digermacyclobutadiene†}, volume = {64}, year = {2025}, }
• (2025). Selectivity modulation of multistep reduction reactions by gold nanoclusters. ANGEW, 64(1), e202413418. (www)

  @article{ , abstract = {The selective synthesis of valuable azo- and azoxyaromatic chemicals via transfer coupling of nitroaromatic compounds has been achieved by fine-tuning the catalyst structure. Here, a direct method to modulate nitrobenzene reduction and selectively alter the product from azobenzene to azoxybenzene by employing the size effect of Au is reported. Au nanoclusters (NCs) with smaller sizes embedded in ZIF-8 controllably converted nitrobenzene into azoxybenzene, while supported Au nanoparticles (NPs) selectively catalyzed nitrobenzene reduction to azobenzene. X-ray photoelectron spectroscopy (XPS) and Diffuse reflectance infrared Fourier transform spectroscopy on CO adsorption (CO-DRIFTS) of Au NC/ZIF-8 revealed a higher valence state and a lower electron density of Au than that of Au NP/ZIF-8, combined with the desorption of azoxybenzene from the Au NC and Au NP surface, suggesting that the Au NCs with lower electron density exhibit stronger adsorption. Density functional theory (DFT) calculations and charge density difference maps indicated that azoxybenzene bonded to Au NC/ZIF-8 with greater adsorption energy, resulting in more electron transfer between azoxybenzene and the generated Au sites, which inhibited further reduction of azoxybenzene and resulted in high azoxybenzene selectivity. The application of the size effect of Au particles to regulate nitrobenzene transfer coupling provided new insights into the structure-selectivity relationships.}, archive = {J_ANGEW}, author = {Jing-Zheng Zhang and Yi-Bao Zhang and Hui-Li Chai and Hui-Ling Luo and Chen-Xia Du and Ren-Wu Huang and Shuang-Quan Zang}, doi = {10.1002/anie.202413418}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413418}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selectivity modulation of multistep reduction reactions by gold nanoclusters}, volume = {64}, year = {2025}, }
• (2025). Electronic metal-support interaction induces hydrogen spillover and platinum utilization in hydrogen evolution reaction. ANGEW, 64(1), e202413417. (www)

  @article{ , abstract = {The substantial promotion of hydrogen evolution reaction (HER) catalytic performance relies on the breakup of the Sabatier principle, which can be achieved by the alternation of the support and electronic metal support interaction (EMSI) is noticed. Due to the utilization of tungsten disulfides as support for platinum (Pt@WS 2 ), surprisingly, Pt@WS 2 demands only 31 mV overpotential to attain 10 mA cm −2 in acidic HER test, corresponding to a 2.5-fold higher mass activity than benchmarked Pt/C. The pH dependent electrochemical measurements associated with H 2 -TPD and in situ Raman spectroscopy indicate a hydrogen spillover involved HER mechanism is confirmed. The WS 2 support triggers a higher hydrogen binding strength for Pt leading to the increment in hydrogen concentration at Pt sites proved by upshifted d band center as well as lower Gibbs free energy of hydrogen, favourable for hydrogen spillover. Besides, the WS 2 shows a comparably lower effect on Gibbs free energy for different Pt layers (−0.50 eV layer −1 ) than carbon black (−0.88 eV layer −1 ) contributing to a better Pt utilization. Also, the theoretical calculation suggests the hydrogen spillover occurs on the 3 rd Pt layer in Pt@WS 2 ; moreover, the energy barrier is lowered with increment in hydrogen coverage on Pt. Therefore, the boosted HER activity attributes to the EMSI effect caused hydrogen spillover and enhancement in Pt utilization efficiency.}, archive = {J_ANGEW}, author = {Yumei Feng and Yuhua Xie and Yingjie Yu and Yazhou Chen and Qingting Liu and Haifeng Bao and Fang Luo and Shuyuan Pan and Zehui Yang}, doi = {10.1002/anie.202413417}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413417}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electronic metal-support interaction induces hydrogen spillover and platinum utilization in hydrogen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). A CaI2-based electrolyte enabled by borate ester anion receptors for reversible Ca−Organic and Ca−Se batteries. ANGEW, 64(1), e202413416. (www)

  @article{ , abstract = {Passivating solid electrolyte interphases (SEIs) in Ca metal anodes constitute a long-standing challenge, as they block Ca 2+ transport and inhibit reversible Ca deposition/stripping. Current solutions focus primarily on boron/aluminum-based electrolytes to mitigate such interfacial issues by producing Ca 2+ -conductive species, yet the complex synthetic procedure of these salts restricts the widespread application. Moreover, whether any inorganic phases possess decent Ca 2+ conductivity within SEIs remains ambiguous. Herein, we report that a commercially available CaI 2 -dimethoxyethane electrolyte supports reversible Ca/Ca 2+ redox reactions via forming CaI 2 -involved SEI, inspired by our density functional theory calculations where CaI 2 species is predicted to possess the lowest Ca 2+ diffusion barrier among a range of inorganic phases. We further materialize this finding by introducing a serial of borate ester anion receptors, resulting in the formation of CaI 2 /borides hybrid SEIs with an enhanced Ca 2+ conductivity. Consequently, the resultant electrolytes realize a 7-fold reduction in deposition/stripping overpotential compared to anion receptor-free one, allowing for the construction of reversible Ca-metal full cells with high-capacity selenium and organic cathodes.}, archive = {J_ANGEW}, author = {Zhen Hou and Rui Zhou and Kai Liu and Junwu Zhu and Biao Zhang}, doi = {10.1002/anie.202413416}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413416}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A CaI2-based electrolyte enabled by borate ester anion receptors for reversible Ca−Organic and Ca−Se batteries}, volume = {64}, year = {2025}, }
• (2025). A supramolecular-nanocage-based framework stabilized by π-π stacking interactions with enhanced photocatalysis. ANGEW, 64(1), e202413413. (www)

  @article{ , abstract = {π frameworks, defined as a type of porous supramolecular materials weaved from conjugated molecular units by π-π stacking interactions, provide a new direction in photocatalysis. However, such examples are rarely reported. Herein, we report a supramolecular-nanocage-based π framework constructed from a photoactive Cu(I) complex unit. Structurally, 24 Cu(I) complex units stack together through π-π stacking interactions, forming a truncated octahedral nanocage with sodalite topology. The inner diameter of the nanocage is 2.8 nm. By sharing four open faces, each nanocage connects with four equivalent ones, forming a 3D porous π framework ( π-2 ). π-2 shows good thermal and chemical stability, which can adsorb CO 2 , iodine, and methyl orange molecules. More importantly, π-2 can serve as a photocatalyst for hydrogen evolution reaction. With ultrafine Pt subnanometer particles (0.9±0.1 nm) incorporated into the nanocages as a co-catalyst, the hydrogen evolution rate reaches a record-high value of 524012 μmol/g Pt /h in the absence of any additional photosensitizers. The high photocatalytic activity can be ascribed to the ultrafine size of the Pt particles, as well as the fast electron transfer from π-2 to the highly active Pt upon illumination. π-2 represents the unique stable supramolecular-cage-based π framework with excellent photocatalytic activity.}, archive = {J_ANGEW}, author = {Jian-Hua Mei and Shan Lai and Yun-Nan Gong and Wen-Jie Shi and Ji-Hua Deng and Tong-Bu Lu and Di-Chang Zhong}, doi = {10.1002/anie.202413413}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413413}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A supramolecular-nanocage-based framework stabilized by π-π stacking interactions with enhanced photocatalysis}, volume = {64}, year = {2025}, }
• (2025). Nanohoops favour light-induced energy transfer over charge separation in Porphyrin/[10]CPP/Fullerene rotaxanes. ANGEW, 64(1), e202413404. (www)

  @article{ , abstract = {[2]Rotaxanes offer unique opportunities for studying and modulating charge separation and energy transfer, because the mechanical bond allows the robust, yet spatially dynamic tethering of photoactive groups. In this work, we synthesized [2]rotaxane triads comprising a central (aza)[10]CPP⊃C 60 bis-adduct complex and two zinc porphyrin stoppers to address how the movable nanohoop affects light-induced charge separation and energy transfer between the rotaxane subcomponents. We found that neither the parent nanohoop [10]CPP nor its electron-deficient analogue aza[10]CPP actively participate in charge separation. In contrast, the nanohoops completely prevented through-space charge separation. This result is likely due to supramolecular “shielding”, because charge separation was observed in the thread that acted as reference dyad. On the other hand, the suppression of electron transfer allowed the observation of energy transfer from the porphyrin triplet to the fullerene triplet state with a lifetime of ca. 25 μs. The presence of the interlocked nanohoops therefore leads to a dramatic switch between charge separation and energy transfer. We suggest that our results explain observations made by others in photovoltaic devices comprising nanohoops and may pave the way toward strategic uses of mechanically interlocked architectures in devices that feature (triplet) energy transfer.}, archive = {J_ANGEW}, author = {Fabian Schwer and Simon Zank and Markus Freiberger and Fabian M. Steudel and Niklas Geue and Lei Ye and Perdita E. Barran and Thomas Drewello and Dirk M. Guldi and Max von Delius}, doi = {10.1002/anie.202413404}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413404}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nanohoops favour light-induced energy transfer over charge separation in Porphyrin/[10]CPP/Fullerene rotaxanes}, volume = {64}, year = {2025}, }
• (2025). Selective monoborylation of methane by a mono bipyridyl-Nickel(II) hydride catalyst. ANGEW, 64(1), e202413402. (www)

  @article{ , abstract = {We report the development of an earth-abundant metal catalyst for methane C−H borylation. The post-synthetic metalation of bipyridine-functionalized zirconium metal-organic framework (MOF) with NiBr 2 , followed by treatment with NaEt 3 BH affords MOF-supported monomeric bipyridyl-nickel(II) dihydride species via active site isolation. The heterogeneous and recyclable nickel catalyst selectively borylates methane at 200 °C using pinacolborane (HBpin) to afford CH 3 Bpin in 61 % yield with a turnover number (TON) up to 1388. The confinement of the active NiH 2 -species within the uniformly porous MOF allows selective monoborylation of methane via shape-selective catalysis by preventing the formation of sterically encumbered overborylated products. Unlike MOF−Ni catalyst, its homogeneous control is almost inactive in methane borylation due to its intermolecular decomposition. Our mechanistic investigation, including spectroscopic, kinetic, and control experiments, as well as DFT calculations, revealed that stabilizing mononuclear bipyridyl-nickel dihydride and diboryl species by MOF is crucial for achieving efficient methane borylation via turnover-limiting σ-bond metathesis. This work shows promise in designing MOF-based abundant metal catalysts for the chemoselective functionalization of methane and other inert molecules into valuable chemicals.}, archive = {J_ANGEW}, author = {Rahul Kalita and Manav Chauhan and Poorvi Gupta and Wahida Begum and Kuntal Manna}, doi = {10.1002/anie.202413402}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413402}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Selective monoborylation of methane by a mono bipyridyl-Nickel(II) hydride catalyst}, volume = {64}, year = {2025}, }
• (2025). Parallel and high throughput reaction monitoring with computer vision. ANGEW, 64(1), e202413395. (www)

  @article{ , abstract = {We report the development and applications of a computer vision based reaction monitoring method for parallel and high throughput experimentation (HTE). Whereas previous efforts reported methods to extract bulk kinetics of one reaction from one video, this new approach enables one video to capture bulk kinetics of multiple reactions running in parallel. Case studies, in and beyond well-plate high throughput settings, are described. Analysis of parallel dye-quenching hydroxylations, DMAP-catalysed esterification, solid-liquid sedimentation dynamics, metal catalyst degradation, and biologically-relevant sugar-mediated nitro reduction reactions have each provided insight into the scope and limitations of camera-enabled high throughput kinetics as a means of widening known analytical bottlenecks in HTE for reaction discovery, mechanistic understanding, and optimisation. It is envisaged that the nature of the multi-reaction time-resolved datasets made available by this analytical approach will later serve a broad range of downstream efforts in machine learning approaches to exploring chemical space.}, archive = {J_ANGEW}, author = {H. Barrington and T. J. D. McCabe and K. Donnachie and Calum Fyfe and A. McFall and M. Gladkikh and J. McGuire and C. Yan and M. Reid}, doi = {10.1002/anie.202413395}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413395}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Parallel and high throughput reaction monitoring with computer vision}, volume = {64}, year = {2025}, }
• (2025). Electrochemical C−O and C−N arylation using alternating polarity in flow for compound libraries. ANGEW, 64(1), e202413383. (www)

  @article{ , abstract = {Etherification and amination of aryl halide scaffolds are commonly used reactions in parallel medicinal chemistry to rapidly scan structure–activity relationships with abundant building blocks. Electrochemical methods for aryl etherification and amination demonstrate broad functional group tolerance and extended nucleophile scope compared to traditional methods. Nevertheless, there is a need for robust and scale-transferable workflows for electrochemical compound library synthesis. Herein we describe a platform for automated electrochemical synthesis of C−X arylation (X=NH, OH) in flow to access compound libraries. A comprehensive Design of Experiment (DoE) study identifies an optimal protocol which generates high yields across>30 aryl halide scaffolds, diverse amines (including electron-deficient sulfonamides, sulfoximines, amides, and anilines) and alcohols (including serine residues within peptides). Reaction sequences are automated on commercially available equipment to generate libraries of anilines and aryl ethers. The unprecedented application of potentiostatic alternating polarity in flow is essential to avoid accumulating electrode passivation. Moreover, it enables reactions to be performed in air, without supporting electrolyte and with high reproducibility over consecutive runs. Our method represents a powerful means to rapidly generate nucleophile independent C−X arylation compound libraries using flow electrochemistry.}, archive = {J_ANGEW}, author = {Jennifer Morvan and Koen P. L. Kuijpers and Dayne Fanfair and Bingqing Tang and Karolina Bartkowiak and Lars van Eynde and Evelien Renders and Jesus Alcazar and Peter J. J. A. Buijnsters and Mary-Ambre Carvalho and Alexander X. Jones}, doi = {10.1002/anie.202413383}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413383}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Electrochemical C−O and C−N arylation using alternating polarity in flow for compound libraries}, volume = {64}, year = {2025}, }
• (2025). Tailoring single-atom coordination environments in carbon nanofibers via flash heating for highly efficient bifunctional oxygen electrocatalysis. ANGEW, 64(1), e202413369. (www)

  @article{ , abstract = {The rational design of carbon-supported transition metal single-atom catalysts necessitates precise atomic positioning within the precursor. However, structural collapse during pyrolysis can occlude single atoms, posing significant challenges in controlling both their utilization and coordination environment. Herein, we present a surface atom adsorption-flash heating (FH) strategy, which ensures that the pre-designed carbon nanofiber structure remains intact during heating, preventing unforeseen collapse effects and enabling the formation of metal atoms in nano-environments with either tetra-nitrogen or penta-nitrogen coordination at different flash heating temperatures. Theoretical calculations and in situ Raman spectroscopy reveal that penta-nitrogen coordinated cobalt atoms (Co-N 5 ) promote a lower energy pathway for oxygen reduction and oxygen evolution reactions compared to the commonly formed Co-N 4 sites. This strategy ensures that Co-N 5 sites are fully exposed on the surface, achieving exceptionally high atomic utilization. The turnover frequency (65.33 s −1 ) is 47.4 times higher than that of 20 % Pt/C under alkaline conditions. The porous, flexible carbon nanofibers significantly enhance zinc-air battery performance, with a high peak power density (273.8 mW cm −2 ), large specific capacity (784.2 mAh g −1 ), and long-term cycling stability over 600 h. Additionally, the flexible fiber-shaped zinc-air battery can power wearable devices, demonstrating significant potential in flexible electronics applications.}, archive = {J_ANGEW}, author = {Qingliang Luo and Kangkang Wang and Qiangqiang Zhang and Wei Ding and Rongwu Wang and Linlin Li and Shengjie Peng and Dongxiao Ji and Xiaohong Qin}, doi = {10.1002/anie.202413369}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413369}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Tailoring single-atom coordination environments in carbon nanofibers via flash heating for highly efficient bifunctional oxygen electrocatalysis}, volume = {64}, year = {2025}, }
• (2025). Redox-inducible radiomimetic photosensitizers selectively suppress cancer cell proliferation by damaging DNA through radical cation chemistry. ANGEW, 64(1), e202413352. (www)

  @article{ , abstract = {Radiotherapy leverages ionizing radiation to kill cancer cells through direct and indirect effects, and direct effects are considered to play an equal or greater role. Several photosensitizers have been developed to mimic the direct effects of radiotherapy, generating radical cations in DNA models, but none has been applied in cellular studies. Here, we design a radiomimetic photosensitizer, producing DNA radical cations in cells for the first time. To reduce adverse effects, several redox-inducible precursors are prepared as cancer cells have elevated levels of GSH and H 2 O 2 . These precursors respond to GSH or H 2 O 2 , releasing the active photosensitizer that captures DNA abasic (AP) sites and generates DNA radical cations upon photolysis, without disrupting the redox state of cells. DNA radical cations migrate freely and are eventually trapped by H 2 O and O 2 to yield DNA lesions, thus triggering DNA damage response. Our study suggests that direct effects of radiotherapy suppress cancer cell proliferation mainly by inducing G2/M phase cell cycle arrest, rather than promoting apoptosis. Synergistic effects of the precursor and chemotherapeutic agents are also observed in combination phototherapy. Beyond highlighting an alternative strategy for phototherapy, this proof-of-concept study affords a facile cellular platform to study the direct effects of radiotherapy.}, archive = {J_ANGEW}, author = {Heli Fan and Luo Wang and Xuanwei Zeng and Chenghe Xiong and Dehao Yu and Xiaofan Zhang and Jiayi Chen and Zhaowei Meng and Anahit Campbell and Wanqiao Huang and Hui Mei and Huabing Sun}, doi = {10.1002/anie.202413352}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413352}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Redox-inducible radiomimetic photosensitizers selectively suppress cancer cell proliferation by damaging DNA through radical cation chemistry}, volume = {64}, year = {2025}, }
• (2025). Glycosylated AIE-active red light-triggered photocage with precisely tumor targeting capability for synergistic type i photodynamic therapy and CPT chemotherapy. ANGEW, 64(1), e202413350. (www)

  @article{ , abstract = {Photocaging is an emerging protocol for precisely manipulating spatial and temporal behaviors over biological activity. However, the red/near-infrared light-triggered photolysis process of current photocage is largely singlet oxygen ( 1 O 2 )-dependent and lack of compatibility with other reactive oxygen species (ROS)-activated techniques, which has proven to be the major bottleneck in achieving efficient and precise treatment. Herein, we reported a lactosylated photocage BT-LRC by covalently incorporating camptothecin (CPT) into hybrid BODIPY-TPE fluorophore via the superoxide anion radical (O 2 − ⋅)-cleavable thioketal bond for type I photodynamic therapy (PDT) and anticancer drug release. Amphiphilic BT-LRC could be self-assembled into aggregation-induced emission (AIE)-active nanoparticles (BT-LRCs) owing to the regulation of carbohydrate-carbohydrate interactions (CCIs) among neighboring lactose units in the nanoaggregates. BT-LRCs could simultaneously generate abundant O 2 − ⋅ through the aggregation modulated by lactose interactions, and DNA-damaging agent CPT was subsequently and effectively released. Notably, the type I PDT and CPT chemotherapy collaboratively amplified the therapeutic efficacy in HepG2 cells and tumor-bearing mice. Furthermore, the inherent AIE property of BT-LRCs endowed the photocaged prodrug with superior bioimaging capability, which provided a powerful tool for real-time tracking and finely tuning the PDT and photoactivated drug release behavior in tumor therapy.}, archive = {J_ANGEW}, author = {Wei Zhou and Yi-chen Liu and Guang-jian Liu and Yuan Zhang and Gai-li Feng and Guo-wen Xing}, doi = {10.1002/anie.202413350}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413350}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Glycosylated AIE-active red light-triggered photocage with precisely tumor targeting capability for synergistic type i photodynamic therapy and CPT chemotherapy}, volume = {64}, year = {2025}, }
• (2025). Surface cladding engineering via oxygen sulfur distribution for stable electrocatalytic oxygen production. ANGEW, 64(1), e202413348. (www)

  @article{ , abstract = {Inevitable leaching and corrosion under anodic oxidative environment greatly restrict the lifespan of most catalysts with excellent primitive activity for oxygen production. Here, based on Fick’ s Law, we present a surface cladding strategy to mitigate Ni dissolution and stabilize lattice oxygen triggering by directional flow of interfacial electrons and strong electronic interactions via constructing elaborately cladding-type NiO/NiS heterostructure with controlled surface thickness. Multiple in situ characterization technologies indicated that this strategy can effectively prevent the irreversible Ni ions leaching and inhibit lattice oxygen from participating in anodic reaction. Combined with density functional theory calculations, we reveal that the stable interfacial O−Ni−S arrangement can facilitate the accumulation of electrons on surficial NiO side and weaken its Ni−O covalency. This would suppress the overoxidation of Ni and simultaneously fixing the lattice oxygen, thus enabling catalysts with boosted corrosion resistance without sacrificing its activity. Consequently, this cladding-type NiO/NiS heterostructure exhibits excellent performance with a low overpotential of 256 mV after 500 h. Based on Fick's law, this work demonstrates the positive effect of surface modification through precisely adjusting of the oxygen-sulfur exchange process, which has paved an innovative and effective way to solve the instability problem of anodic oxidation.}, archive = {J_ANGEW}, author = {Shengjie Zi and Jiamin Zhu and Yue Zhai and Yang Hu and Nan Zhang and Shuhui Li and Luohua Liu and Li An and Pinxian Xi and Chun-Hua Yan}, doi = {10.1002/anie.202413348}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413348}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Surface cladding engineering via oxygen sulfur distribution for stable electrocatalytic oxygen production}, volume = {64}, year = {2025}, }
• (2025). Polydopamine-mediated contact-electro-catalysis for efficient partial oxidation of methane. ANGEW, 64(1), e202413343. (www)

  @article{ , abstract = {The direct conversion and efficient utilization of methane pose a critical scientific challenge. Indirect activation via reactive oxygen species (ROS) offers a high probability of contact with methane and conversion efficiency under mild conditions. However, reported product yields are suboptimal due to challenges in activating oxygen and facilitating mass transfer in suspension systems. We propose the use of contact-electro-catalysis (CEC), employing polydopamine (PDA) as a catalyst that undergoes electron transfer with oxygen under ultrasound, generating ROS that drives the partial oxidation of methane (POM). Corresponding experimental results indicate that CH 3 OH and most HCHO are produced directly from CH 4 . Furthermore, through in situ characterizations, we have shown that light pretreatment of the catalysts in an oxygenated atmosphere facilitates the forming of more C=O functional groups with strong electron-withdrawing properties, thereby significantly enhancing overall product yields, particularly for CH 3 OH. Within two hours, product yields reach 1.5 mmol g cat −1 for HCHO and 0.9 mmol g cat −1 for CH 3 OH. This work introduces a novel approach for efficient POM, while highlighting the distinctive catalytic properties of PDA.}, archive = {J_ANGEW}, author = {Taikang Jia and Wenjing Wang and Chuanqi Zhang and Ling Zhang and Wenzhong Wang}, doi = {10.1002/anie.202413343}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413343}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polydopamine-mediated contact-electro-catalysis for efficient partial oxidation of methane}, volume = {64}, year = {2025}, }
• (2025). Temperature-dependent left- and right-twisted conformational changes in 1: 1 host-guest systems: Theoretical modeling and chiroptical simulations. ANGEW, 64(1), e202413340. (www)

  @article{ , abstract = {An efficient strategy for high-performance chiral materials is to design and synthesize host molecules with left- and right- ( M - and P -)twisted conformations and to control their twisted conformations. For this, a quantitative analysis is required to describe the chiroptical inversion, chiral transfer, and chiral recognition in the host-guest systems, which is generally performed using circular dichroism (CD) and/or proton nuclear magnetic resonance ( 1 H NMR) spectroscopies. However, the mass-balance model that considers the M - and P -twisted conformations has not yet been established. In this study, we derived the novel equations based on the mass-balance model for the 1 : 1 host-guest systems. Then, we further applied them to analyze the 1 : 1 host-guest systems for the achiral calixarene-based capsule molecule, achiral dimeric zinc porphyrin tweezer molecule, and chiral pillar[5]arene with the chiral and/or achiral guest molecules by using the data obtained from the CD titration, variable temperature CD (VT−CD), and 1 H NMR experiments. The thermodynamic parameters (Δ H and Δ S ), equilibrium constants ( K ), and molar CD (Δ ϵ ) in the 1 : 1 host-guest systems could be successfully determined by the theoretical analyses using the derived equations.}, archive = {J_ANGEW}, author = {Nozomu Suzuki and Daisuke Taura and Yusuke Furuta and Yudai Ono and Senri Miyagi and Ryota Kameda and Takeharu Haino}, doi = {10.1002/anie.202413340}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413340}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Temperature-dependent left- and right-twisted conformational changes in 1: 1 host-guest systems: Theoretical modeling and chiroptical simulations}, volume = {64}, year = {2025}, }
• (2025). Unveiling the structure and dissociation of interfacial water on RuO2 for efficient acidic oxygen evolution reaction. ANGEW, 64(1), e202413334. (www)

  @article{ , abstract = {Understanding the structure and dynamic process of interfacial water molecules at the catalyst-electrolyte interface on acidic oxygen evolution reaction (OER) kinetics is highly desirable for the development of proton exchange membrane water electrolyzers. Herein, we construct a series of p -block metal elements (Ga, In, Sn) doped RuO 2 catalysts with manipulated electronic structure and Ru−O covalency to investigate the effect of electrochemical interfacial engineering on the improvement of acidic OER activity. Associated with operando attenuated total reflectance surface-enhanced infrared absorption spectroscopy measurements and theoretical analysis, we uncover the free-H 2 O enriched local environment and dynamic evolution from 4-coordinated hydrogen-bonded water and 2-coordinated hydrogen-bonded water to free-H 2 O on the surface of Ga−RuO 2 , are responsible for the optimized connectivity of hydrogen bonding network in the electrical double layer by promoting solvent reorganization. In addition, the structurally ordered interfacial water molecules facilitate high-efficiency proton-coupled electron transfer across the interface, leading to reduced energy barrier of the follow-up dissociation process and enhanced acidic OER performance. This work highlights the key role of structure and dynamic process of interfacial water for acidic OER, and demonstrates the electrochemical interfacial engineering as an efficient strategy to design high-performance electrocatalysts.}, archive = {J_ANGEW}, author = {Liqing Wu and Wenxia Huang and Dongyang Li and Hongnan Jia and Bingbing Zhao and Juan Zhu and Haiqing Zhou and Wei Luo}, doi = {10.1002/anie.202413334}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413334}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the structure and dissociation of interfacial water on RuO2 for efficient acidic oxygen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Subnanometer diameter control in nanotubes self-assembled via consecutive cyclization – Polymerization processes. ANGEW, 64(1), e202413321. (www)

  @article{ , abstract = {Tubular self-assembled architectures are highly appealing supramolecular objects that participate in diverse essential biological processes. Controlling with precision their dimensions, and in particular their pore diameter, is a key objective to develop the full applied potential of these structures. Here, using a strategy that relies on the controlled supramolecular polymerization of Watson–Crick H-bonded macrocycles, we target the assembly of 3 sets of nanotubes in which pore diameter is finely controlled from 1.8, to 3.2 and to 4.3 nm. This is simply done by elongating the oligo(phenylene-ethynylene) block placed in between guanine and cytosine nucleobases in the monomer. Moreover, this structural change leads to a gradual reduction in the chelate cooperativity of the cyclization process and, at the same time, to an enhancement in the tendency of the macrocycles to stack, which critically influences the coupling between these consecutive supramolecular processes.}, archive = {J_ANGEW}, author = {Marina González-Sánchez and María J. Mayoral and Fátima Aparicio and Violeta Vázquez-González and Irene Sancho-Casado and Eduardo Anaya-Plaza and David González-Rodríguez}, doi = {10.1002/anie.202413321}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413321}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Subnanometer diameter control in nanotubes self-assembled via consecutive cyclization – Polymerization processes}, volume = {64}, year = {2025}, }
• (2025). Cobalt-catalyzed regio-, diastereo- and enantioselective reductive coupling of 1,3-dienes and aldehydes. ANGEW, 64(1), e202413313. (www)

  @article{ , abstract = {Catalytic regio-, diastereo- and enantioselective reductive coupling of 1,3-dienes and aldehydes through regio- and enantioselective oxidative cyclization followed by regio- and diastereoselective protonation promoted by a chiral phosphine-cobalt complex is presented. Such processes represent an unprecedented reaction pathway for cobalt catalysis that enable selective transformation of the more substituted alkene in 1,3-dienes, affording a broad scope of bishomoallylic alcohols without the need of pre-formation of stoichiometric amounts of sensitive organometallic reagents in up to 98 % yield, >98 : 2 regioselectivity, >98 : 2 dr and 98 : 2 er. Application of this method to construction of axial stereogenicity and deuterated stereogenic center provided a wide range of multifunctional chiral building blocks that are otherwise difficult to access. DFT calculations revealed the origin of regio- and stereoselectivity as well as a unique oxidative cyclization mechanism for cobalt catalysis.}, archive = {J_ANGEW}, author = {Yu Wang and Danrui Wang and Shilin Wang and Qinglei Chong and Zhihan Zhang and Fanke Meng}, doi = {10.1002/anie.202413313}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413313}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cobalt-catalyzed regio-, diastereo- and enantioselective reductive coupling of 1,3-dienes and aldehydes}, volume = {64}, year = {2025}, }
• (2025). Regulating electron-phonon coupling by solid additive for efficient organic solar cells. ANGEW, 64(1), e202413309. (www)

  @article{ , abstract = {Strong electron-phonon coupling can hinder exciton transport and induce undesirable non-radiative recombination, resulting in a shortened exciton diffusion distance and constrained exciton dissociation in organic solar cells (OSCs). Therefore, suppressing electron-phonon coupling is crucially important for achieveing high-performance OSCs. Here, we employ the solid additive to regulating electron-phonon coupling in OSCs. The planar configuration of SA1 confers a significant advantage in suppressing lattice vibrations in the active layers, reducing the scattering of excitons by phonons. Consequently, a slow but sustained hole transfer process is identified in the SA1-assisted film, indicating an enhancement in hole transfer efficiency. Prolonged exciton diffusion length and exciton lifetime are achieved in the blend film processed with SA1, attributed to a low non-radiative recombination rate and low energetic disorder for charge carrier transport. As a result, a high efficiency of 20 % was achieved for ternary device with a remarkable short-circuit current. This work highlights the important role of suppressing electron-phonon coupling in improving the photovoltaic performance of OSCs.}, archive = {J_ANGEW}, author = {Zhongwei Ge and Jiawei Qiao and Yun Li and Jiali Song and Xiaopeng Duan and Zhen Fu and Haixia Hu and Renqiang Yang and Hang Yin and Xiaotao Hao and Yanming Sun}, doi = {10.1002/anie.202413309}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413309}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating electron-phonon coupling by solid additive for efficient organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Unveiling the aggregation of M−N−C single atoms into highly efficient MOOH nanoclusters during alkaline water oxidation. ANGEW, 64(1), e202413308. (www)

  @article{ , abstract = {M−N−C-type single-atom catalysts (SACs) are highly efficient for the electrocatalytic oxygen evolution reaction (OER). And the isolated metal atoms are usually considered real active sites. However, the oxidative structural evolution of coordinated N during the OER will probably damage the structure of M−N−C, hence resulting in a completely different reaction mechanism. Here, we reveal the aggregation of M−N−C materials during the alkaline OER. Taking Ni−N−C as an example, multiple characterizations show that the coordinated N on the surface of Ni−N−C is almost completely dissolved in the form of NO 3 − , accompanied by the generation of abundant O functional groups on the surface of the carbon support. Accordingly, the Ni−N bonds are broken. Through a dissolution-redeposition mechanism and further oxidation, the isolated Ni atoms are finally converted to NiOOH nanoclusters supported by carbon as the real active sites for the enhanced OER. Fe−N−C and Co−N−C also have similar aggregation mechanism. Our findings provide unique insight into the structural evolution and activity origin of M−N−C-based catalysts under electrooxidative conditions.}, archive = {J_ANGEW}, author = {Shanshan Lu and Zhipu Zhang and Chuanqi Cheng and Bin Zhang and Yanmei Shi}, doi = {10.1002/anie.202413308}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413308}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling the aggregation of M−N−C single atoms into highly efficient MOOH nanoclusters during alkaline water oxidation}, volume = {64}, year = {2025}, }
• (2025). Designing cooperative ion transport pathway in ultra-thin solid-state electrolytes toward practical lithium metal batteries. ANGEW, 64(1), e202413306. (www)

  @article{ , abstract = {Solid polymer electrolytes (SPEs) are promising for high-energy-density solid-state Li metal batteries due to their decent flexibility, safety, and interfacial stability. However, their development was seriously hindered by the interfacial instability and limited conductivity, leading to inferior electrochemical performance. Herein, we proposed to design ultra-thin solid-state electrolyte with long-range cooperative ion transport pathway to effectively increase the ionic conductivity and stability. The impregnation of PVDF−HFP inside pores of fluorinated covalent organic framework (CF 3 −COF) can disrupt its symmetry, rendering rapid ion transportation and inhibited anion immigration. The functional groups of CF 3 −COF can interact with PVDF−HFP to form fast Li + transport channels, which enables the uniform and confined Li + conduction within the electrolyte. The introduction of CF 3 −COF also enhances the mechanical strength and flexibility of SPEs, as well as ensures homogeneous Li deposition and inhibited dendrite growth. Hence, a remarkably high conductivity of 1.21×10 −3 S cm −1 can be achieved. Finally, the ultra-thin SPEs with an extremely long cycle life exceed 9000 h can be obtained while the NCM523/Li pouch cell demonstrates a high capacity of 760 mAh and 96 % capacity retention after cycling, holding great promises to be utilized for practical solid-state Li metal batteries.}, archive = {J_ANGEW}, author = {Guo Feng and Qianyi Ma and Dan Luo and Tingzhou Yang and Yihang Nie and Zhuoyi Zheng and Leixin Yang and Shibin Li and Qingying Li and MingLiang Jin and Xin Wang and Zhongwei Chen}, doi = {10.1002/anie.202413306}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413306}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Designing cooperative ion transport pathway in ultra-thin solid-state electrolytes toward practical lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Nickel-catalyzed atroposelective carbo-carboxylation of alkynes with CO2: En route to axially chiral carboxylic acids. ANGEW, 64(1), e202413305. (www)

  @article{ , abstract = {Precise synthesis of carboxylic acids via catalytic carboxylation with CO 2 is highly appealing. Although considerable advancements have been achieved in difunctionalizing carboxylation of unsaturated hydrocarbons, the asymmetric variants are conspicuously underdeveloped, particularly in addressing axially chiral alkenes. Herein, we report the first catalytic atroposelective carboxylation of alkynes with CO 2 . A variety of valuable axially chiral carboxylic acids are obtained with good yields and high chemo-, regio-, Z/E and enantio-selectivities. Notably, an unexpected anti -selective carbo-carboxylation is observed in the sp 2 -hybrid carbo-electrophile-initiated reductive carboxylation of alkynes. Mechanistic studies including DFT calculation elucidate the origin of chiral induction and anti -selectivity in vinyl-carboxylation of alkynes.}, archive = {J_ANGEW}, author = {Chao Li and Xiao-Wang Chen and Li-Li Liao and Yong-Yuan Gui and Jing-Wei Yang and Shuo Zhang and Jun-Ping Yue and Xiangge Zhou and Jian-Heng Ye and Yu Lan and Da-Gang Yu}, doi = {10.1002/anie.202413305}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413305}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nickel-catalyzed atroposelective carbo-carboxylation of alkynes with CO2: En route to axially chiral carboxylic acids}, volume = {64}, year = {2025}, }
• (2025). Engineering spacer conjugation for efficient and stable 2D/3D perovskite solar cells and modules. ANGEW, 64(1), e202413303. (www)

  @article{ , abstract = {Incorporating two-dimensional (2D) perovskite in 3D perovskite absorber holds great potential to improve the stability and efficiency of perovskite solar cells (PSCs). However, the bulky-cation-based 2D structures often exhibit poor charge transport and are prone to formation of charge-extraction barrier that impedes efficient device operation. We address these issues by introducing aromatic spacers with molecular conjugation into 2D perovskites locating between 3D perovskites and electron charge transport layers. Among our tested aromatic spacers, the pyrenylbutanamine (PyBA) spacer was shown to endow 2D perovskites with superior charge transport properties and efficient charge extraction from the bulk perovskite in 2D/3D PSCs, due to the highest degree of conjugation. As a result, we achieved a power conversion efficiency (PCE) of up to 25.3 % in a 0.16-cm 2 single cell and 21.0 % in a 24.8-cm 2 module. Moreover, the incorporated PyBA substantially raised the resistance of 2D/3D PSCs against moisture and ion migration, resulting in enhanced environmental, thermal, and operational stability. Notably, the PyBA-based devices retained over 90 % of their initial PCE after 2000 hours at 25 °C and 80 % relative humidity, or 1000 hours at 85 °C and 85 % humidity, or 3000 hours of operation under continuous 1-Sun illumination at 40 °C, showcasing their exceptionally high stability compared to previously reported 2D/3D PSCs.}, archive = {J_ANGEW}, author = {Jinping Zhang and Liangli Chu and Tianjun Liu and Bingkun Tian and Weicun Chu and Xiangnan Sun and Riming Nie and Wei Zhang and Zhuhua Zhang and Xiaoming Zhao and Wanlin Guo}, doi = {10.1002/anie.202413303}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413303}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering spacer conjugation for efficient and stable 2D/3D perovskite solar cells and modules}, volume = {64}, year = {2025}, }
• (2025). Proton-coupled electron transfer in photoelectrochemical alcohol oxidation enhanced by nickel-based cocatalysts. ANGEW, 64(1), e202413298. (www)

  @article{ , abstract = {Using biomass oxidation reactions instead of water oxidation reactions is optimal for accomplishing biomass conversion and effective hydrogen generation. Here, we report that α-Fe 2 O 3 photoanodes with a NiOOH cocatalyst exhibit excellent performance for photoelectrochemical oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA). The conversion efficiency for HMF reaches 98.5 %, while the selectivity for FDCA is 94.2 %. We revealed that HMF is oxidized through a spontaneous proton-coupled electron transfer (PCET) process with the high-valent phase of the Ni-based catalyst. The dangling oxygen and bridging oxygen of the high-valent phase species serve as proton-accepting sites. Furthermore, we pointed out that the deprotonated bond dissociation free energy difference between the catalysts and alcohols is the thermodynamic trigger for the PCET process. This study provides a reasonable explanation for the alcohol oxidation reaction, which is beneficial for designing biomass conversion systems.}, archive = {J_ANGEW}, author = {Bin Gao and Xiaowei Mu and Jianyong Feng and Huiting Huang and Jianming Liu and Wangxi Liu and Zhigang Zou and Zhaosheng Li}, doi = {10.1002/anie.202413298}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413298}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Proton-coupled electron transfer in photoelectrochemical alcohol oxidation enhanced by nickel-based cocatalysts}, volume = {64}, year = {2025}, }
• (2025). Highly stable propane dehydrogenation on a self-supporting single-component Zn2SiO4 catalyst. ANGEW, 64(1), e202413297. (www)

  @article{ , abstract = {Current industrial propane dehydrogenation (PDH) processes predominantly use either toxic Cr-based or expensive Pt-based catalysts, necessitating urgent exploration for alternatives. Herein, we present Zn 2 SiO 4 , an easily prepared, cost-effective material, as a highly efficient and stable catalyst for PDH. Uniquely, Zn 2 SiO 4 nanocrystals do not require dispersion on support materials, commonly needed for catalytic active oxide clusters, but function as a self-supporting catalyst instead. During the reaction‘s induction period, surface Zn species on the Zn 2 SiO 4 crystal reduce to coordinately unsaturated ZnO x single sites, serving as highly active catalytic centers. The Zn 2 SiO 4 catalyst demonstrates a stable performance over 200 hours of PDH operation at 550 °C. We further find that introducing a minuscule amount of CO 2 into the propane feed significantly extends the catalyst lifespan to over 2000 hours. This enhancement arises from the special role of CO 2 in facilitating the removal of strongly adsorbed H*, preventing the complete reduction of ZnO x . After prolonged reaction, the activity of Zn 2 SiO 4 can be fully restored by etching the surface layer to expose fresh Zn species, available throughout the crystals. The combination of CO 2 introduction and catalytic site regeneration strategies is expected to enable a year-long PDH operation using a single batch of Zn 2 SiO 4 catalyst.}, archive = {J_ANGEW}, author = {Zhaohui Liu and Min Mao and Tie Shu and Qingpeng Cheng and Dong Liu and Jianjian Wang and Yun Zhao and Lingmei Liu and Yu Han}, doi = {10.1002/anie.202413297}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413297}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly stable propane dehydrogenation on a self-supporting single-component Zn2SiO4 catalyst}, volume = {64}, year = {2025}, }
• (2025). γ-ray driven aqueous-phase methane conversions into complex molecules up to glycine. ANGEW, 64(1), e202413296. (www)

  @article{ , abstract = {Fundamental understanding of initial evolutions of molecules in the universe is of great interest and importance. CH 4 is one of the abundant simple molecules in the universe. Herein we report γ-ray, high-energy photons commonly existing in cosmic rays and unstable isotope decay, as an external energy to efficiently drives aqueous-phase CH 4 conversions to various products with the presence of oxygen at room temperature. Glycine also forms with an additional introduction of ammonia. Both CH 4 conversions and product distributions are modified by solid granules, and a CH 3 COOH selectivity as high as 82 % is obtained when SiO 2 is added. Our results point to γ-ray driven aqueous-phase CH 4 conversions as a likely formation network of initial complex organic compounds in the universe and offer an alternative strategy for efficiently utilizing CH 4 as the carbon source to produce value-added products at mild conditions, a long-standing challenging task in heterogeneous catalysis.}, archive = {J_ANGEW}, author = {Fei Fang and Xiao Sun and Yuanxu Liu and Zhiwen Jiang and Mozhen Wang and Xuewu Ge and Weixin Huang}, doi = {10.1002/anie.202413296}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413296}, shortjournal = {Angew. Chem. Int. Edit.}, title = {γ-ray driven aqueous-phase methane conversions into complex molecules up to glycine}, volume = {64}, year = {2025}, }
• (2025). Planar chiral charge-transfer cyclophanes: Convenient synthesis, circularly polarized light-responsive photothermal conversion and supramolecular chiral assembly. ANGEW, 64(1), e202413295. (www)

  @article{ , abstract = {We report herein a series of macrocycles in which the densely π-stacked charge-transfer (CT) donor/acceptor with naphthalenediimides (NDIs) or perylene diimide (PDI) as acceptor moiety pairing various donor moieties are locked by covalent bond. The X-ray crystallography of C8BDT-NDI reveals a short intramolecular π-stacking distance around 3.4 Å and the existence of intermolecular donor/acceptor π-stacking (3.7 Å). The intramolecular CT is highly dependent on the electron-donating ability of donor moiety and replacing carbazole ( C8KZ ) with benzo[1,2-b:4,5-b′]dithiophene ( C8BDT ) or dihydroindolo[3,2-b]indole ( C8DN ) redshift CT absorption into NIR region. Notably, both C8BDT-NDI and C8DN-NDI demonstrate excellent photothermal performance, which is a result of the active non-radiative pathways. Interestingly, the different molecular symmetry between donor and acceptor moiety in cyclophanes endow C8BDT-NDI and C8DN-NDI with intrinsic planar chirality. The enantiomeric C8BDT-NDI shows chiral selectivity for incident light, i.e., when irradiated by left-circularly polarized light, ( R)- C8BDT-NDI is more sensitive and a higher maximum stable temperature is achieved. While, enantiomeric C8DN-NDI pack with different orientations forming M- and P -handedness helix, respectively, demonstrating molecular planar chirality being transferred and amplified through molecular assembly. These results provide insight into the intramolecular charge transfer in enforced D/A π-stacks in which CT interactions and planar chirality would be engineered through structural control.}, archive = {J_ANGEW}, author = {Zhengyan Wang and Yiping Liu and Xiuni Quan and Wenxuan Zhang and Renjun Tan and Hao Gu and Chunqi Sheng and Chunbo Duan and Pengyao Xing and Jun-Hua Wan}, doi = {10.1002/anie.202413295}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413295}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Planar chiral charge-transfer cyclophanes: Convenient synthesis, circularly polarized light-responsive photothermal conversion and supramolecular chiral assembly}, volume = {64}, year = {2025}, }
• (2025). Development of controllable hetero-pauson-khand polymerization to functional stimuli-responsive poly(γ-lactam)s. ANGEW, 64(1), e202413275. (www)

  @article{ , abstract = {Polymers containing lactam structures play a crucial role in both natural biological systems and human life, and their synthesis, functions and applications are of utmost importance for biomimetics and the creation of new materials. In this study, we developed an efficient heterogeneous Pauson–Khand polymerization (h-PKP) method for the controlled synthesis of main-chain poly(γ-lactam)s containing α, β-unsaturated γ-lactam functionalities using readily available internal alkynes and imines. The molecular weights of the resulting poly( N −Ts/γ-lactam)s can be precisely controlled by adjusting the ratio of phenyl formate and nickel. These polymers exhibit high solid-state luminescence and demonstrate rapid and sensitive dual responsiveness to light and acid stimuli. They further demonstrate strong reactive oxygen species (ROS) generation capability. The unique dual-emission peaks observed in poly( N −H/γ-lactam)s obtained through post-treatment under acidic conditions demonstrate a mechanism of aggregation-induced intermolecular excited-state proton transfer specific to lactam structures. The efficient one-pot synthetic method for poly(γ-lactam) provides a novel strategy for constructing polymers with γ-lactam structures in the main chain and the simple and efficient post-modification method offer a versatile toolbox for functionalizing poly(γ-lactam)s to expand their potential applications.}, archive = {J_ANGEW}, author = {Wutong Du and Xinyue Liu and Feiyi Sun and Jacky W. Y. Lam and Jinglei Yang and Ben Zhong Tang}, doi = {10.1002/anie.202413275}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413275}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Development of controllable hetero-pauson-khand polymerization to functional stimuli-responsive poly(γ-lactam)s}, volume = {64}, year = {2025}, }
• (2025). Engineering lattice oxygen regeneration of NiFe layered double hydroxide enhances oxygen evolution catalysis durability. ANGEW, 64(1), e202413250. (www)

  @article{ , abstract = {The lattice oxygen mechanism (LOM) endows NiFe layered double hydroxide (NiFe-LDH) with superior oxygen evolution reaction (OER) activity, yet the frequent evolution and sluggish regeneration of lattice oxygen intensify the dissolution of active species. Herein, we overcome this challenge by constructing the NiFe hydroxide/Ni 4 Mo alloy (NiFe-LDH/Ni 4 Mo) heterojunction electrocatalyst, featuring the Ni 4 Mo alloy as the oxygen pump to provide oxygenous intermediates and electrons for NiFe-LDH. The released lattice oxygen can be timely offset by the oxygenous species during the LOM process, balancing the regeneration of lattice oxygen and assuring the enhancement of the durability. In consequence, the durability of NiFe-LDH is significantly enhanced after the modification of Ni 4 Mo with an impressive durability for over 60 h, much longer than that of NiFe-LDH counterpart with only 10 h. In situ spectra and first-principle simulations reveal that the adsorption of OH − is significantly strengthened owing to the introduction of Ni 4 Mo, ensuring the rapid regeneration of lattice oxygen. Moreover, NiFe-LDH/Ni 4 Mo-based anion exchange membrane water electrolyzer (AEMWE) presents an impressive durability for over 150 h at 100 mA cm −2 . The oxygen pump strategy opens opportunities to balance the evolution and regeneration of lattice oxygen, enhancing the durability of efficient OER catalysts.}, archive = {J_ANGEW}, author = {Fengyu Wu and Fenyang Tian and Menggang Li and Shuo Geng and Longyu Qiu and Lin He and Lulu Li and Zhaoyu Chen and Yongsheng Yu and Weiwei Yang and Yanglong Hou}, doi = {10.1002/anie.202413250}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413250}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Engineering lattice oxygen regeneration of NiFe layered double hydroxide enhances oxygen evolution catalysis durability}, volume = {64}, year = {2025}, }
• (2025). A bis-boron amino acid for positron emission tomography and boron neutron capture therapy. ANGEW, 64(1), e202413249. (www)

  @article{ , abstract = {Trifluoroborate boronophenylalanine (BBPA) is a boron amino acid analog of 4-boronophenylalanine (BPA) but with a trifluoroborate group (−BF 3 − ) instead of a carboxyl group (−COOH). Clinical studies have shown that 18 F−labeled BBPA ([ 18 F]BBPA) can produce high-contrast tumor images in positron emission tomography (PET). Beyond PET imaging, BBPA is a theranostic agent for boron neutron capture therapy (BNCT). Because BBPA possesses an identical chemical structure to BNCT and PET, it can potentially predict the boron concentration for BNCT using [ 18 F]BBPA-PET. The synthesis of BBPA was achieved by selectively fluorinating the α-aminoborate compound, taking advantage of the varying rates of solvolysis of the B−F bond. The study showcased the high-contrast [ 18 F]BBPA-PET imaging in various tumor models, highlighting its broad applicability for both [ 18 F]BBPA-PET and BBPA-BNCT. [ 18 F]BBPA-PET tumor uptake remains consistent across various doses, including those used in BNCT. This enables accurate estimation of the boron concentration in tumors using [ 18 F]BBPA-PET. With its dual boron structure, BBPA increases boron concentration in tumor cells and tumor tissues compared to BPA. Thus, less boron carrier is needed. This study introduces a new theranostic boron carrier that enhances boron accumulation in tumors, predicts boron concentration, and enhances the accuracy and effectiveness of BNCT.}, archive = {J_ANGEW}, author = {Junyi Chen and Mengxin Xu and Zhu Li and Ziren Kong and Jie Cai and Chunhong Wang and Bo-Shuai Mu and Xi-Yang Cui and Zizhu Zhang and Tong Liu and Zhibo Liu}, doi = {10.1002/anie.202413249}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413249}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A bis-boron amino acid for positron emission tomography and boron neutron capture therapy}, volume = {64}, year = {2025}, }
• (2025). Boosting reactive oxygen species generation via contact-electro-catalysis with FeIII-initiated self-cycled fenton system. ANGEW, 64(1), e202413246. (www)

  @article{ , abstract = {Contact Electro-Catalysis (CEC) using commercial dielectric materials in contact-separation cycles with water can trigger interfacial electron transfer and induce the generation of reactive oxygen species (ROS). However, the inherent hydrophobicity of commercial dielectric materials limits the effective reaction sites, and the generated ROS inevitably undergo self-combination to form hydrogen peroxide (H 2 O 2 ). In typical CEC systems, H 2 O 2 does not further decompose into ROS, leading to suboptimal reaction rates. Addressing the generation and activation of H 2 O 2 is therefore crucial for advancing CEC. Here, we synthesized a catalyst by loading the dielectric material polytetrafluoroethylene (PTFE) onto ZSM-5 (PTFE/ZSM-5, PZ for short), achieving uniform dispersion of the catalyst in water for the first time. The introduction of an Fe III -initiated self-cycling Fenton system (SF-CEC), with the synergistic effects of O 2 activation and Fe III -activated H 2 O 2 , further enhanced ROS generation. In the Fe III -initiated SF-CEC system, the synergistic effects of ROS and protonated azo dyes enabled nearly 99 % degradation of azo dyes within 10 minutes, a sixfold improvement compared to the CEC system. This represents the fastest degradation rate of methyl orange dye induced by ultrasound to date. Without extra oxidants, this system enabled stable dissolution of precious metals in weakly acidic solutions at room temperature, achieving 80 % gold dissolution within 2 hours, 2.5 times faster than similar CEC systems. This study also corrects the unfavorable perception of CEC applications under acidic conditions, providing new insights for the fields of dye degradation and precious metal recovery.}, archive = {J_ANGEW}, author = {Weixin Li and Jialuo Tu and Jikai Sun and Yuanbao Zhang and Jiale Fang and Mingda Wang and Xiangyu Liu and Zhong-Qun Tian and Feng Ru Fan}, doi = {10.1002/anie.202413246}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413246}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting reactive oxygen species generation via contact-electro-catalysis with FeIII-initiated self-cycled fenton system}, volume = {64}, year = {2025}, }
• (2025). Probing twist-induced endocytotic membrane fission using anisotropic gold homodimers. ANGEW, 64(1), e202413244. (www)

  @article{ , abstract = {Membrane fission involves a crucial step of lipid remodeling, in which the dynamin collar constricts and severs the tubulated lipid membrane at the neck of budding vesicles. Nevertheless, the difficulty in accurately determining the rotational dynamics of live endocytotic vesicles poses a limit on the elucidation of dynamin-induced membrane remodeling for endocytotic vesicle scission. Herein, we designed a DNA-modified gold homodimer (AuHD)-based anisotropic plasmonic probe with uniform surface chemistry, minimizing orientational fluctuation within vesicle encapsulation. Using AuHDs as cargos to image the dynamics of cargo-containing vesicles during endocytosis, we showed that, prior to detachment from plasma membrane, the cargo-containing vesicles underwent multiple intermittent twists of ~4° angular orientation relative to plasma membrane with a ~0.2 s dwell time. These findings suggest that the membrane torques resulting from dynamin actions in vivo constitute the pathway to membrane fission, potentially shedding light on how dynamin-mediated lipid remodeling orchestrates membrane fission.}, archive = {J_ANGEW}, author = {Zhiying Fan and Xiuhai Mao and Meng Zhu and Xingjie Hu and Mingqiang Li and Lulu Huang and Jie Li and Tumala Maimaiti and Xiaolei Zuo and Chunhai Fan and Qian Li and Mengmeng Liu and Yang Tian}, doi = {10.1002/anie.202413244}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413244}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Probing twist-induced endocytotic membrane fission using anisotropic gold homodimers}, volume = {64}, year = {2025}, }
• (2025). As aggregation-induced emission meets with noncovalent conformational locks: Subtly regulating NIR-II molecules for multimodal imaging-navigated synergistic therapies. ANGEW, 64(1), e202413219. (www)

  @article{ , abstract = {Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near-infrared (NIR-II) fluorescence and prominent photothermal conversion ability is highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose a molecular design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation-induced emission (AIE) in a single formulation is able to boost multiple photophysical properties for efficient phototheranostics. The introduction of NoCLs skeleton with conformation-locking feature in the center of molecular architecture indeed elevates the structural planarity and rigidity, which simultaneously promotes the absorption capacity and bathochromic-shifts the emission wavelength centered in NIR-II region. Meanwhile, the AIE tendency mainly originated from flexibly propeller-like geometry at the ends of molecular architecture eventually endows the molecule with satisfactory emission intensity and photothermal conversion in aggregates. Consequently, by utilizing the optimized molecule, unprecedented performance on NIR-II fluorescence-photoacoustic-photothermal trimodal imaging-guided photothermal-chemo synergistic therapy is demonstrated by the precise tumor diagnosis and complete tumor ablation.}, archive = {J_ANGEW}, author = {Jiangao Li and Niu Niu and Deliang Wang and Jun Zhu and Xue Li and Qiyu Kong and Ben Zhong Tang and Dong Wang}, doi = {10.1002/anie.202413219}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413219}, shortjournal = {Angew. Chem. Int. Edit.}, title = {As aggregation-induced emission meets with noncovalent conformational locks: Subtly regulating NIR-II molecules for multimodal imaging-navigated synergistic therapies}, volume = {64}, year = {2025}, }
• (2025). Boosting k+-ionic conductivity of layered oxides via regulating P2/P3 heterogeneity and reciprocity for room-temperature quasi-solid-state potassium metal batteries. ANGEW, 64(1), e202413214. (www)

  @article{ , abstract = {Solid-state potassium metal batteries are promising candidates for grid-scale energy storage due to their low cost, high energy density and inherent safety. However, solid state K-ion conductors struggle with poor ionic conductivity due to the large ionic radius of K + -ions. Herein, we report precise regulation of phase heterogeneity and reciprocity of the P2/P3-symbiosis K 0.62 Mg 0.54 Sb 0.46 O 2 solid electrolyte (SE) for boosting a high ionic conductivity of 1.6×10 −4 S cm −1 at 25 °C. The bulk ionic conducting mechanism is explored by elucidating the effect of atomic stacking mode within the layered framework on K + -ion migration barriers. For ion diffusion at grain boundaries, the P2/P3 biphasic symbiosis property assists in tunning the SE microstructure, which crystallizes in rod-like particles with lengths of tens of micrometers facilitating long-distance ion transport and significantly decreasing grain boundary resistance. Potassium metal symmetric cells using the modified SE deliver excellent cycling life over 300 h at 0.1 mA cm −2 and a high critical current density of 0.68 mA cm −2 . The quasi-solid-state potassium metal batteries (QSSKBs) coupled with two kinds of layered oxide cathodes demonstrate remarkable stability over 300 cycles, outperforming the liquid electrolyte counterparts. The QSSKB system provides a promising strategy for high-efficiency, safe, and durable large-scale energy storage.}, archive = {J_ANGEW}, author = {Xinyuan Zhang and Boqian Yi and Wanqing Jia and Shuoqing Zhao and Serguei Savilov and Shiyu Yao and Ze Xiang Shen and Gang Chen and Zhixuan Wei and Fei Du}, doi = {10.1002/anie.202413214}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413214}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Boosting k+-ionic conductivity of layered oxides via regulating P2/P3 heterogeneity and reciprocity for room-temperature quasi-solid-state potassium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Radical-based enantioconvergent reductive couplings of racemic allenes and aldehydes. ANGEW, 64(1), e202413198. (www)

  @article{ , abstract = {Transition metal-catalyzed radical-based enantioconvergent reactions have become a powerful strategy to synthesize enantiopure compounds from racemic starting materials. However, existing methods primarily address precursors with central chirality, neglecting those with axial chirality. Herein, we describe the enantioconvergent reductive coupling of racemic allenes with aldehydes, facilitated by a photoredox, chromium, and cobalt triple catalysis system. This method selectively affords one product from sixteen possible regio- and stereoisomers. The protocol leverages Co III −H mediated hydrogen atom transfer (MHAT) and Cr-catalyzed radical-polar crossover for efficient stereoablation of axial chirality and asymmetric addition, respectively. Supported by mechanistic insights from control experiments, deuterium labeling, and DFT calculations, our approach offers synthetic chemists a valuable tool for creating enantioenriched chiral homoallylic alcohols, promising to advance radical-based strategies for synthesizing complex chiral molecules.}, archive = {J_ANGEW}, author = {Haigen Shen and Ling Yang and Mingrui Xu and Zhaoxin Shi and Ke Gao and Xiaowen Xia and Zhaobin Wang}, doi = {10.1002/anie.202413198}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413198}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Radical-based enantioconvergent reductive couplings of racemic allenes and aldehydes}, volume = {64}, year = {2025}, }
• (2025). Sublimation transformation synthesis of dual-atom fe catalysts for efficient oxygen reduction reaction. ANGEW, 64(1), e202413179. (www)

  @article{ , abstract = {Dual-atom catalysts (DACs) have garnered significant interest due to their remarkable catalytic reactivity. However, achieving atomically precise control in the fabrication of DACs remains a major challenge. Herein, we developed a straightforward and direct sublimation transformation synthesis strategy for dual-atom Fe catalysts (Fe 2 /NC) by utilizing in situ generated Fe 2 Cl 6 (g) dimers from FeCl 3 (s). The structure of Fe 2 /NC was investigated by aberration-corrected transmission electron microscopy and X-ray absorption fine structure (XAFS) spectroscopy. As-obtained Fe 2 /NC, with a Fe−Fe distance of 0.3 nm inherited from Fe 2 Cl 6 , displayed superior oxygen reduction performance with a half-wave potential of 0.90 V (vs. RHE), surpassing commercial Pt/C catalysts, Fe single-atom catalyst (Fe 1 /NC), and its counterpart with a common and shorter Fe−Fe distance of ~0.25 nm (Fe 2 /NC-S). Density functional theory (DFT) calculations and microkinetic analysis revealed the extended Fe−Fe distance in Fe 2 /NC is crucial for the O 2 adsorption on catalytic sites and facilitating the subsequent protonation process, thereby boosting catalytic performance. This work not only introduces a new approach for fabricating atomically precise DACs, but also offers a deeper understanding of the intermetallic distance effect on dual-site catalysis.}, archive = {J_ANGEW}, author = {Li Yan and Yu Mao and Yingxin Li and Qihao Sha and Kai Sun and Panpan Li and Geoffrey I. N. Waterhouse and Ziyun Wang and Shubo Tian and Xiaoming Sun}, doi = {10.1002/anie.202413179}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413179}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Sublimation transformation synthesis of dual-atom fe catalysts for efficient oxygen reduction reaction}, volume = {64}, year = {2025}, }
• (2025). Ultrafast tailoring amorphous Zn0.25V2O5 with precision-engineered artificial atomic-layer 1T′-MoS2 cathode electrolyte interphase for advanced aqueous zinc-ion batteries. ANGEW, 64(1), e202413173. (www)

  @article{ , abstract = {Vanadium (V)-based oxides as cathode materials for aqueous zinc-ion batteries (AZIBs) still encounter challenges such as sluggish Zn 2+ diffusion kinetics and V-dissolution, thus leading to severe capacity fading and limited life span. Here, we designed an ultrafast and facile colloidal chemical synthesis strategy based on crystalline Zn 0.25 V 2 O 5 ( c- ZVO) to successfully prepare a- ZVO@MoS 2 core@shell heterostructures, where atomic-layer MoS 2 uniformly coats on the surface of amorphous a- ZVO. The tailored amorphous structure of a- ZVO provides more isotropic pathways and active sites for Zn 2+ , thus significantly enhancing the Zn 2+ diffusion kinetics during charge–discharge processes. Meanwhile, as an efficient artificial cathode electrolyte interphase, the precision-engineered atomic-layer MoS 2 with semi-metallic 1T′ phase not only contributes to improved electron transport but also effectively inhibits the V-dissolution of a- ZVO. Therefore, the prepared a- ZVO@MoS 2 and conceptually validated a- V 2 O 5 @MoS 2 derived from commercial c- V 2 O 5 exhibit excellent cycling stability at an ultralow current density (0.05 A g −1 ) while maintaining good rate capability and capacity retention. This research achievement provides a new effective strategy for various amorphous cathode designs for AZIBs with superior performance.}, archive = {J_ANGEW}, author = {Chen Hu and Binjie Li and Kunkun Nie and Ziyi Wang and Yujia Zhang and Lixin Yi and Xiaorong Hao and Huang Zhang and Shaokun Chong and Zhengqing Liu and Wei Huang}, doi = {10.1002/anie.202413173}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413173}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ultrafast tailoring amorphous Zn0.25V2O5 with precision-engineered artificial atomic-layer 1T′-MoS2 cathode electrolyte interphase for advanced aqueous zinc-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Accelerated proton-coupled electron transfer via engineering palladium sub-nanoclusters for scalable electrosynthesis of hydrogen peroxide. ANGEW, 64(1), e202413159. (www)

  @article{ , abstract = {Electrosynthesis of H 2 O 2 from oxygen reduction reaction via a two-electron pathway is vital as an alternative for the energy-intensive anthraquinone process. However, this process is largely hindered in neutral and alkaline conditions due to sluggish kinetics associated with the transformation of intermediate O 2 * into OOH* via proton-coupled electron transfer sourced from slow water dissociation. Herein, we developed Pd sub-nanoclusters on the nickel ditelluride nanosheets (Pd SNCs/NiTe 2 ) to enhance the performance of H 2 O 2 electrosynthesis. The newly-developed Pd SNCs/NiTe 2 exhibited a H 2 O 2 selectivity of as high as 99 % and a positive shift of onset potential up to 0.81 V. Combined theoretical calculations and experimental studies (e.g., X-ray absorption and attenuated total reflectance-Fourier transform infrared spectra measurements) revealed that the Pd sub-nanoclusters supported by NiTe 2 nanosheets efficiently reduced the energy barrier of water dissociation to generate more protons, facilitating the proton feeding kinetics. When used in a flow cell, Pd SNCs/NiTe 2 cathode efficiently produced H 2 O 2 with a maximum yield rate of 1.75 mmol h −1 cm −2 and a current efficiency of 95 % at 100 mA cm −2 . Further, an accumulated H 2 O 2 concentration of 1.43 mol L −1 was reached after 10 hours of continuous electrolysis, showing the potential for practical H 2 O 2 electrosynthesis.}, archive = {J_ANGEW}, author = {Yan Li and Yingnan Liu and Xianyun Peng and Zilin Zhao and Zhongjian Li and Bin Yang and Qinghua Zhang and Lecheng Lei and Liming Dai and Yang Hou}, doi = {10.1002/anie.202413159}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413159}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Accelerated proton-coupled electron transfer via engineering palladium sub-nanoclusters for scalable electrosynthesis of hydrogen peroxide}, volume = {64}, year = {2025}, }
• (2025). High-temperature solid-state post-synthetic modification of highly luminescent Cu(I) metallacycles toward new luminescent thermic tracers. ANGEW, 64(1), e202413151. (www)

  @article{ , abstract = {A new luminescent Cu(I) tetrametallic metallacycle B is reported that features very rare semi-bridging aqua ligands. When heated markedly above room temperature, this compound undergoes a post-synthetic transformation in the solid-state, affording the new luminescent metallacycle C . Thermogravimetric analysis, IR spectroscopy and single-crystal X-ray diffraction reveal that this alteration preserves the gross tetrametallic macrocycle structure, but is caused by the release of the coordinated water molecules with the concomitant formation of cuprophilic interactions. This transition induces a shift from eye-perceived green ( B ) to blue ( C ) room-temperature luminescence for these molecular solids. Photophysical measurements and time-dependent density-functional theory calculations have been conducted to identify the origins of the emission properties lying in these structurally related assemblies, and suggest that thermally activated delayed fluorescence dominates the radiative relaxation pathways. This study highlights the innovative feature of Cu(I) derivatives, offering access to stimuli-sensitive materials that can witness, a posteriori, the exceeding of critical temperatures in their environment.}, archive = {J_ANGEW}, author = {Adrien Schlachter and Chendong Xu and Jana Schiller and Raquel Utrera Melero and Sébastien Kerneis and Guillaume Calvez and Karine Costuas and Manfred Scheer and Christophe Lescop}, doi = {10.1002/anie.202413151}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413151}, shortjournal = {Angew. Chem. Int. Edit.}, title = {High-temperature solid-state post-synthetic modification of highly luminescent Cu(I) metallacycles toward new luminescent thermic tracers}, volume = {64}, year = {2025}, }
• (2025). The swiss army knife of electrodes: Pillar[6]arene-modified electrodes for molecular electrocatalysis over a wide pH range. ANGEW, 64(1), e202413144. (www)

  @article{ , abstract = {Molecularly-modified electrode materials that maintain stability over a broad pH range are rare. Typically, each electrochemical transformation necessitates a specifically tuned system to achieve strong binding and high activity of the catalyst. Here, we report the functionalisation of mesoporous indium tin oxide (mITO) electrodes with the macrocyclic host molecule pillar[6]arene (PA[6]). These electrodes are stable within the pH range of 2.4–10.8 and can be equipped with electrochemically active ruthenium complexes through host–guest interactions to perform various oxidation reactions. Benzyl alcohol oxidation serves as a model reaction in acidic media, while ammonia oxidation is conducted to assess the systems performance under basic conditions. PA[6]-modified electrodes demonstrate catalytic activity for both reactions when complexed to different guest molecules and can be reused by reabsorption of the catalyst after its degradation. Furthermore, the system can be employed to perform subsequent reactions in electrolyte with varying pH, enabling the same electrode to be utilised in multiple different electrocatalytic reactions.}, archive = {J_ANGEW}, author = {Helena Roithmeyer and Jan Bühler and Olivier Blacque and Isik Tuncay and Thomas Moehl and Cristiano Invernizzi and Florian Keller and Marcella Iannuzzi and S. David Tilley}, doi = {10.1002/anie.202413144}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413144}, shortjournal = {Angew. Chem. Int. Edit.}, title = {The swiss army knife of electrodes: Pillar[6]arene-modified electrodes for molecular electrocatalysis over a wide pH range}, volume = {64}, year = {2025}, }
• (2025). Thienyltriazine triamides: Thickness insensitive interlayer materials featuring fine-tuned optoelectronic and aggregation characters for efficient organic solar cells. ANGEW, 64(1), e202413135. (www)

  @article{ , abstract = {A novel class of thienyltriazine triamides (TTTAs) was facile synthesized and firstly used as cathode interlayers (CILs) for organic solar cells (OSCs). By utilizing different aromatic arms and pendant polar groups, their optoelectronic properties and aggregation behaviors were effectively modulated. The combination of thienyltriazine (TT) core, naphthylamide arm and imidazole pendant group endows TT−N−M with suitable energy levels, intensified work function tunability, higher conductivity, and well-balanced crystallinity and film-forming ability, boosting both the performance and stability of OSCs significantly. Remarkably, the solar cell efficiency remains stable at around 90 % of the optimal efficiency even as the interlayer thickness varied from 5 to 95 nm, demonstrating its insensitivity to thickness. Moreover, TT−N−M exhibits compatibility with various active layer systems, achieving a maximum efficiency of 19.60 % for single-junction solar cell. Its exceptional tolerance to thickness fluctuations and performance establishes a new benchmark for multi-armed CIL-based OSCs, also positioning them among the most high-performing CIL materials documented thus far. This work not only broadens the scope of CIL materials for OSCs but also offers deep insights into design strategies and structure-properties relationships, being beneficial for the future development of more efficient CIL materials for organic optoelectronic applications.}, archive = {J_ANGEW}, author = {Wenxu Liu and Junjie Wen and Haicheng Yu and Xin Zhan and Yuxing Wang and Lei Zhang and Yanhui Fan and Zuhao You and Yao Liu}, doi = {10.1002/anie.202413135}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413135}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thienyltriazine triamides: Thickness insensitive interlayer materials featuring fine-tuned optoelectronic and aggregation characters for efficient organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Polyethylene recycling via water activation by ball milling. ANGEW, 64(1), e202413132. (www)

  @article{ , abstract = {Polyethylene (PE) is the most prevalent type of plastic waste and also the most challenging to depolymerize because of its inert carbon-carbon (C−C) bonds. [1] High temperature and noble metals are usually required for depolymerization. [2] To avoid using noble metals, costly reagents and harsh reaction conditions, it is worthwhile but challenging to explore new reaction pathways. [3] We report an unprecedented mechanochemical reaction of PE and water to result in shorter-chain alkanes, alkenes, alcohols, and ketones (C n , where n≲50), with above 80 % of starting carbon converted into these products, which could be a valuable feedstock for re-entering chemical value chains. This reaction is driven solely by ball milling, without heating and pressurizing. No costly catalysts are used. Instead, only earth-abundant Al 2 O 3 was milled with reactants.}, archive = {J_ANGEW}, author = {Linfeng Li and Markus Leutzsch and Phil Hesse and Chuanhao Wang and Bolun Wang and Ferdi Schüth}, doi = {10.1002/anie.202413132}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413132}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyethylene recycling via water activation by ball milling}, volume = {64}, year = {2025}, }
• (2025). Generation of triplet states by host-stabilized through-space conjugation for the construction of efficient supramolecular photocatalysts. ANGEW, 64(1), e202413129. (www)

  @article{ , abstract = {Promoting the generation of triplet states is essential for developing efficient photocatalytic systems. This research presents a novel approach of host-stabilized through-space conjugation via the combination of covalent and non-covalent methods. The designed building block, 4,4′-(1,4(1,4)-dibenzene cyclohexaphane-1,4-diyl)bis(1-phenylpyridinium) chloride, features inherently stable through-space conjugation. When this block forms a 1 : 1 host–guest complex with cucurbit[8]uril, the through-space conjugation is further stabilized within the confined cavity. Both the generation and lifetime of triplet state are significantly increased, resulting from the host-stabilized through-space conjugation. Additionally, the ultrahigh binding constant of 6.58×10 14 M −1 ensures the persistence of host-stabilization effect. As a result, the host–guest complex acts as a highly efficient catalyst in the photocatalytic oxidation of thioether and aromatic alcohol. In the photodegradation of lignin, a complex natural product, the host–guest complex also exhibits high efficiency, demonstrating its robustness. This line of research is anticipated to enrich the toolbox of supramolecular photochemistry and provide a strategy for fabricating efficient supramolecular photocatalysts.}, archive = {J_ANGEW}, author = {Weiquan Xu and Yinghao Du and He Ma and Xingchen Tang and Qi Ou and Jiang-Fei Xu and Xi Zhang}, doi = {10.1002/anie.202413129}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413129}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Generation of triplet states by host-stabilized through-space conjugation for the construction of efficient supramolecular photocatalysts}, volume = {64}, year = {2025}, }
• (2025). Nebulized immunotherapy of orthotopic lung cancer by mild Magnetothermal–Based innate immunity activations. ANGEW, 64(1), e202413127. (www)

  @article{ , abstract = {Advances in adaptive immunity have greatly contributed to the development of cancer immunotherapy. However, its over-low efficacy and insufficient invasion of immune cells in the tumor tissue, and safety problems caused by cytokine storm, have seriously impeded further clinical application for solid tumor immunotherapy. Notably, the immune microenvironment of the lungs is naturally enriched with alveolar macrophages (AMs). Herein, we introduce a novel nebulized magnetothermal immunotherapy strategy to treat orthotopic lung cancer by using magnetothermal nanomaterial (Zn−CoFe 2 O 4 @Zn−MnFe 2 O 4 −PEG, named ZCMP), which can release iron ions via an acid/thermal-catalytic reaction to maximize the use of lung‘s immune environment through the cascade activations of AMs and natural killer (NK) cells. Nebulized administration greatly enhance drug bioavailability by localized drug accumulation at the lesion site. Upon mild magnetic hyperthermia, the released iron ions catalyze endogenous H 2 O 2 decomposition to produce reactive oxygen species (ROS), which triggers the M1 polarization of AMs, and the resultant inflammatory cytokine IFN-β, IL-1β and IL-15 releases to activate c-Jun, STAT5 and GZMB related signaling pathways, promoting NK cells proliferation and activation. This innovative strategy optimally utilizes the lung‘s immune environment and shows excellent immunotherapeutic outcomes against orthotopic lung cancer.}, archive = {J_ANGEW}, author = {Lizhu Chen and Ping Hu and Wenming Fang and Tong Wu and Jianlin Shi}, doi = {10.1002/anie.202413127}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413127}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nebulized immunotherapy of orthotopic lung cancer by mild Magnetothermal–Based innate immunity activations}, volume = {64}, year = {2025}, }
• (2025). Atom-efficient synthesis of trimethine cyanines using formaldehyde as a single-carbon source. ANGEW, 64(1), e202413121. (www)

  @article{ , abstract = {Herein, we present an innovative and atom-efficient synthesis of trimethine cyanines (Cy3) using formaldehyde (FA) as a single-carbon reagent. The widespread application of Cy3 dyes in bioimaging and genomics/proteomics is often limited by synthetic routes plagued by low atom economy and substantial side-product formation. Through systematic investigation, we have developed a practical and efficient synthetic pathway for both symmetrical and unsymmetrical Cy3 derivatives, significantly minimizing resource utilization. Notably, this approach yields water as the by-product, in alignment with sustainable chemistry principles. Moreover, the efficient one-pot synthesis facilitates the detection of intracellular FA levels, utilizing the fluorescence signal of Cy3 in live cells. It is also possible to detect endogenous FA in the intestinal tissues. We observed a significant decrease in FA in the small intestine of inflammatory bowel disease (IBD) mice as compared to healthy mice. This methodological advancement not only enhances the scope of fluorescent dye synthesis but also contributes to sustainable practices within chemical manufacturing, offering a significant leap forward in the development of environmentally friendly synthetic strategies.}, archive = {J_ANGEW}, author = {Sun Hyeok Lee and Taek-Jun Lee and Sourav Sarkar and Heewon Cho and Quynh Pham Nguyen Nhu and Young-Tae Chang}, doi = {10.1002/anie.202413121}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413121}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Atom-efficient synthesis of trimethine cyanines using formaldehyde as a single-carbon source}, volume = {64}, year = {2025}, }
• (2025). Long-term single-molecule tracking in living cells using weak-affinity protein labeling. ANGEW, 64(1), e202413117. (www)

  @article{ , abstract = {Single-particle tracking (SPT) has become a powerful tool to monitor the dynamics of membrane proteins in living cells. However, permanent labeling strategies for SPT suffer from photobleaching as a major limitation, restricting observation times, and obstructing the study of long-term cellular processes within single living cells. Here, we use exchangeable HaloTag Ligands (xHTLs) as an easy-to-apply labeling approach for live-cell SPT and demonstrate extended observation times of individual living cells of up to 30 minutes. Using the xHTL/HaloTag7 labeling system, we measure the ligand-induced activation kinetics of the epidermal growth factor receptor (EGFR) in single living cells. We generate spatial maps of receptor diffusion in cells, report non-uniform distributions of receptor mobility, and the formation of spatially confined ‘hot spots’ of EGFR activation. Furthermore, we measured the mobility of an ER-luminal protein in living cells and found diffusion coefficients that correlated with the ER nano-structure. This approach represents a general strategy to monitor protein mobility in a functional context and for extended observation times in single living cells.}, archive = {J_ANGEW}, author = {Claudia Catapano and Marina S. Dietz and Julian Kompa and Soohyen Jang and Petra Freund and Kai Johnsson and Mike Heilemann}, doi = {10.1002/anie.202413117}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413117}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Long-term single-molecule tracking in living cells using weak-affinity protein labeling}, volume = {64}, year = {2025}, }
• (2025). Ligand-insertion strategy for constructing 2D conjugated Metal–Organic framework with large pore size for electrochemical analytics. ANGEW, 64(1), e202413115. (www)

  @article{ , abstract = {Two-dimensional conjugated metal–organic frameworks (2D c -MOFs) have shown great promise in various electrochemical applications due to their intrinsic electrical conductivity. A large pore aperture is a favorable feature of this type of material because it facilitates the mass transport of chemical species and electrolytes. In this work, we propose a ligand insertion strategy in which a linear ligand is inserted into the linkage between multitopic ligands, extending the metal ion into a linear unit of -M-ligand-M-, for the construction of 2D c -MOFs with large pore apertures, utilizing only small ligands. As a proof-of-concept trial of this strategy, a 2D c -MOF with mesopores of 3.2 nm was synthesized using commercially available ligands hexahydrotriphenylene and 2,5-dihydroxybenzoquinone. The facilitation of the diffusion of redox species by the large pore size of this MOF was demonstrated through a series of probes. With this feature, it showed superior performance in the electrochemical analysis of a variety of biological species.}, archive = {J_ANGEW}, author = {Xiu-Zhen Wang and Yue Chen and Xiao-Min Cao and Ru-Yi Li and Wei-Yan Chen and Yue Li and Dong-Sheng Guo}, doi = {10.1002/anie.202413115}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413115}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Ligand-insertion strategy for constructing 2D conjugated Metal–Organic framework with large pore size for electrochemical analytics}, volume = {64}, year = {2025}, }
• (2025). Heterogeneous nucleation regulation amends unfavorable crystallization orientation and defect features of antimony selenosulfide film for high-efficient planar solar cells. ANGEW, 64(1), e202413108. (www)

  @article{ , abstract = {Antimony selenosulfide (Sb 2 (S,Se) 3 ) has obtained widespread concern for photovoltaic applications as a light absorber due to superior photoelectric features. Accordingly, various deposition technologies have been developed in recent years, especially hydrothermal deposition method, which has achieved a great success. However, device performances are limited with severe carrier recombination, relating to the quality of absorber and interfaces. Herein, bulk and interface defects are simultaneously suppressed by regulating heterogeneous nucleation kinetics with barium dibromide (BaBr 2 ) introduction. In details, the Br adsorbs and dopes on the polar planes of cadmium sulfide (CdS) buffer layer, promoting the exposure of nonpolar planes of CdS, which facilitates the favorable growth of [hk1]-Sb 2 (S,Se) 3 films possessing superior crystallinity and small interface defects. Additionally, the Se/S ratio is increased due to the replacement of Se by Br, causing a downshift of the Fermi levels with a benign band alignment and a shallow-level defect. Moreover, Ba 2+ is located at grain boundaries by coordination with S and Se ions, passivating grain boundary defects. Consequently, the efficiency is increased from 7.70 % to 10.12 %. This work opens an avenue towards regulating the heterogeneous nucleation kinetics of Sb 2 (S,Se) 3 film deposited via hydrothermal deposition approach to optimize its crystalline orientation and defect features.}, archive = {J_ANGEW}, author = {Donglou Ren and Chen Li and Jun Xiong and Weizheng Liang and Michel Cathelinaud and Xianghua Zhang and Shuo Chen and Zhiqiang Li and Daocheng Pan and Guangxing Liang and Bingsuo Zou}, doi = {10.1002/anie.202413108}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413108}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Heterogeneous nucleation regulation amends unfavorable crystallization orientation and defect features of antimony selenosulfide film for high-efficient planar solar cells}, volume = {64}, year = {2025}, }
• (2025). Synthesis of multifunctional organic molecules via michael addition reaction to manage perovskite crystallization and defect. ANGEW, 64(1), e202413105. (www)

  @article{ , abstract = {Additive engineering plays a pivotal role in achieving high-quality light-absorbing layers for high-performance and stable perovskite solar cells (PSCs). Various functional groups within the additives exert distinct regulatory effects on the perovskite layer. However, few additive molecules can synergistically fulfill the dual functions of regulating crystallization and passivating defects. Here, we custom-synthesized 2-ureido-4-pyrimidone (UPy) organic small molecules with diverse functional groups as additives to modulate crystallization and defects in perovskite films via the Michael addition reaction. Theoretical and experimental investigations demonstrate that the −OH groups in UPy exhibit significant effects in fixing uncoordinated Pb 2+ ions, passivation of lead-iodide antisite defects, alleviating hysteresis, and reducing non-radiative recombination. Furthermore, the enhanced C=O and −NH 2 motifs interact with the A-site cation via hydrogen bonding, which relieves residual strain and adjusts crystal orientation. This strategy effectively controls perovskite crystallization and passivates defects, ultimately enhancing the quality of perovskite films. Consequently, the open-circuit voltage of the UPy-based p-i-n PSCs reaches 1.20 V, and the fill factor surpasses 84 %. The champion device delivers a power conversion efficiency of 25.75 %. Remarkably, the unencapsulated device maintained 96.9 % and 94.5 % of its initial efficiency following 3,360 hours of dark storage and 1,866 hours of 1-sun illumination, respectively.}, archive = {J_ANGEW}, author = {Hongbo Liang and Jing Chen and Wenjing Zhu and Fengqiang Ma and Na Li and Hao Gu and Junmin Xia and Yuexin Lin and Wenhan Yang and Sen Zhang and Yueshuai Zhang and Bingyu Han and Shengchun Yang and Shujiang Ding and Chao Liang}, doi = {10.1002/anie.202413105}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413105}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Synthesis of multifunctional organic molecules via michael addition reaction to manage perovskite crystallization and defect}, volume = {64}, year = {2025}, }
• (2025). Organocatalytic atroposelective synthesis of axially chiral indolyl ketosulfoxonium ylides. ANGEW, 64(1), e202413102. (www)

  @article{ , abstract = {Despite recent advancements in the catalytic generation of axial chirality, reports on non-biaryl atropisomers remain limited because of the stringent steric requirements necessary to establish effective rotational brakes. Herein, we present a novel class of monoaryl atropisomers, indolyl ketosulfoxonium ylides, and describe an organocatalytic protocol for their synthesis. We discovered that a chiral phosphoric acid (CPA) serves as an effective catalyst for the highly enantioselective iodination of ortho -aminophenylethynyl sulfoxonium ylides. Under the optimized reaction conditions, a strong preference for the intended iodination process over the competing protonation was observed. Subsequently, intramolecular amide cyclization enabled the formation of sterically congested indole fragments. Furthermore, the synthetic utility of the products was demonstrated by showcasing versatile transformations into other chiral scaffolds with complete retention of optical purity.}, archive = {J_ANGEW}, author = {Ji-Wei Zhang and Yichi Zhang and Yong Huang}, doi = {10.1002/anie.202413102}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413102}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Organocatalytic atroposelective synthesis of axially chiral indolyl ketosulfoxonium ylides}, volume = {64}, year = {2025}, }
• (2025). Experimental insights into the formation, reactivity, and crosstalk of thionitrite (SNO−) and perthionitrite (SSNO−). ANGEW, 64(1), e202413092. (www)

  @article{ , abstract = {Hydrogen sulfide (H 2 S) and nitric oxide (NO) are important gaseous biological signaling molecules that are involved in complex cellular pathways. A number of physiological processes require both H 2 S and NO, which has led to the proposal that different H 2 S/NO⋅ crosstalk species, including thionitrite (SNO − ) and perthionitrite (SSNO − ), are responsible for this observed codependence. Despite the importance of these S/N hybrid species, the reported properties and characterization, as well as the fundamental pathways of formation and subsequent reactivity, remain poorly understood. Herein we report new experimental insights into the fundamental reaction chemistry of pathways to form SNO − and SSNO − , including mechanisms for proton-mediated interconversion. In addition, we demonstrate new modes of reactivity with other sulfur-containing potential crosstalk species, including carbonyl sulfide (COS).}, archive = {J_ANGEW}, author = {Amanda G. Davis and Michael D. Pluth}, doi = {10.1002/anie.202413092}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413092}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Experimental insights into the formation, reactivity, and crosstalk of thionitrite (SNO−) and perthionitrite (SSNO−)}, volume = {64}, year = {2025}, }
• (2025). Li2ZnCu3 modified cu current collector to regulate li deposition. ANGEW, 64(1), e202413065. (www)

  @article{ , abstract = {Rationally designing a current collector that can maintain low lithium (Li) porosity and smooth morphology while enduring high-loading Li deposition is crucial for realizing the high energy density of Li metal batteries, but it is still challengeable. Herein, a Li 2 ZnCu 3 alloy-modified Cu foil is reported as a stable current collector to fulfill the stable high-loading Li deposition. Benefiting from the in situ alloying, the generated numerous Li 2 ZnCu 3 @Cu heterojunctions induce a homogeneous Li nucleation and dense growth even at an ultrahigh capacity of 12 mAh cm −2 . Such a spatial structure endows the overall Li 2 ZnCu 3 @Cu electrode with the manipulated steric hindrance and outmost surface electric potential to suppress the side reactions during Li stripping and plating. The resultant Li||Li 2 ZnCu 3 @Cu asymmetric cell preserves an ultrahigh average Coulombic efficiency of 99.2 % at 3 mA cm −2 /6 mAh cm −2 over 200 cycles. Moreover, the Li-Li 2 ZnCu 3 @Cu||LiFePO 4 cell maintains a cycling stability of 87.5 % after 300 cycles. After coupling with the LiCoO 2 cathode (4 mAh cm −2 ), the cell exhibits a high energy density of 407.4 Wh kg −1 with remarkable cycling reversibility at an N/P ratio of 3. All these findings present a doable way to realize the high-capacity, dendrite-free, and dense Li deposition for high-performance Li metal batteries.}, archive = {J_ANGEW}, author = {Jiaqi Cao and Weixin Chen and Aosong Gao and Dilxat Muhtar and Guangyuan Du and Guoyu Qian and Xueyi Lu and Fangyan Xie and Yang Sun and Xia Lu}, doi = {10.1002/anie.202413065}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413065}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Li2ZnCu3 modified cu current collector to regulate li deposition}, volume = {64}, year = {2025}, }
• (2025). Thermoelectric performance in triplet-ground-state polymer intrinsically boosted by enhanced proquinoidal characteristic. ANGEW, 64(1), e202413061. (www)

  @article{ , abstract = {Over the past decade, polymer thermoelectric materials featuring flexibility, lightness, and bio-friendliness have been paid increasing attention as promising candidates for waste heat recovery and energy generation. For a long time, the dominant approach to optimizing the thermoelectric performance of most organic materials is chemical doping, which, however, is not always ideal for practical applications due to its tendency to involve intricate processing procedure and trigger material and device instability. Currently, the pursuit of single-component neutral thermoelectric materials without exogenous doping presents a compelling alternative. In this work, we designed and synthesized a high-spin polymer material, PBBT-TT, by simultaneously employing thieno[3,4- b ]thiophene (T b T) and benzo[1,2- c : 4,5- c ′]bis[1,2,5]thiadiazole (BBT) units with pronounced proquinoidal characteristics, its analogue, PBBT-T to demonstrate the effect of the T b T unit was also synthesized. The results indicate that because of the enhanced quinoidal resonance, increased spin density and strong intermolecular antiferromagnetic coupling, PBBT-TT exhibits high intrinsic electrical conductivity and Seebeck coefficient, which showcases an outstanding power factor of 26.1 μW m −1 K −2 without doping. This achievement surpasses other neutral organic conjugated polymer and radical conductors, and is even comparable to some typical early-stage doped polymers. Notably, PBBT-TT exhibits remarkable ambient stability, retaining its initial thermoelectric performance over a 120-day period. Our finding demonstrates that modulating the intermolecular spin interactions in open-shell polymers through the introduction of strong proquinoidal units is an effective strategy for the development of doping-free, intrinsically high-performance polymer thermoelectric materials.}, archive = {J_ANGEW}, author = {Runshi Wu and Yu Wei and Xiaojuan Dai and Liqin Yan and Wuyue Liu and Dafei Yuan and Jia Zhu and Xiaozhang Zhu}, doi = {10.1002/anie.202413061}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413061}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermoelectric performance in triplet-ground-state polymer intrinsically boosted by enhanced proquinoidal characteristic}, volume = {64}, year = {2025}, }
• (2025). A multiresponsive ferrocene-based chiral overcrowded alkene twisting liquid crystals. ANGEW, 64(1), e202413047. (www)

  @article{ , abstract = {The reversible modulation of chirality has gained significant attention not only for fundamental stereochemical studies but also for numerous applications ranging from liquid crystals (LCs) to molecular motors and machines. This requires the construction of switchable molecules with (multiple) chiral elements in a highly enantioselective manner, which is often a significant synthetic challenge. Here, we show that the dimerization of an easily accessible enantiopure planar chiral ferrocene-indanone building block affords a multi-stimuli-responsive dimer (FcD) with pre-determined double bond geometry, helical chirality, and relative orientation of the two ferrocene motifs in high yield. This intrinsically planar chiral switch can not only undergo thermal or photochemical E/Z isomerization but can also be reversibly and quantitatively oxidized to both a monocationic and a dicationic state which is associated with significant changes in its (chir)optical properties. Specifically, FcD acts as a chiral dopant for cholesteric LCs with a helical twisting power (HTP) of 13 μm −1 which, upon oxidation, drops to near zero, resulting in an unprecedently large redox-tuning of the LC reflection color by up to 84 nm. Due to the straightforward stereoselective synthesis, FcD, and related chiral switches, are envisioned to be powerful building blocks for multi-stimuli-responsive molecular machines and in LC-based materials.}, archive = {J_ANGEW}, author = {Maximilian Fellert and Robert Hein and Alexander Ryabchun and Yohan Gisbert and Charlotte N. Stindt and Ben L. Feringa}, doi = {10.1002/anie.202413047}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413047}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A multiresponsive ferrocene-based chiral overcrowded alkene twisting liquid crystals}, volume = {64}, year = {2025}, }
• (2025). Self-standing covalent organic polymer membrane with high stability and enhanced ion-sieving effect for flow battery. ANGEW, 64(1), e202413046. (www)

  @article{ , abstract = {Fabrication of ion-conducting membranes with continuous sub-nanometer channels holds fundamental importance for flow batteries in achieving safe integration of renewable energy into grids. Self-standing covalent organic polymer (COP) membranes provide feasibility due to their rapid and selective ion transport. However, the development of a scale-up possible, mechanically robust and chemically stable membranes remains a significant challenge. Herein, using irreversible strong secondary amine linkage, we propose a self-standing COP membrane with sub-nanometer pores ranging from 4.5 to 6.4 Å, by a simple and efficient in situ polymerization approach. This membrane exhibits enhanced selectivity for proton and vanadium ions, especially excellent electrochemical stability, delivering an energy efficiency of over 80 % at the current density of 200 mA cm −2 over 1000 cycles for an all-vanadium redox flow battery (VFB). This study provides novel insights for COP-based ion-sieving membranes in sustainable energy fields.}, archive = {J_ANGEW}, author = {Yihan Zhen and Ziang Xu and Qingbin Cao and Maobin Pang and Qin Xu and Dongchen Lin and Jing Liu and Baoguo Wang}, doi = {10.1002/anie.202413046}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413046}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Self-standing covalent organic polymer membrane with high stability and enhanced ion-sieving effect for flow battery}, volume = {64}, year = {2025}, }
• (2025). Coordination induced spin state transition switches the reactivity of nickel (II) porphyrin in hydrogen evolution reaction. ANGEW, 64(1), e202413042. (www)

  @article{ , abstract = {Electron spin plays a critical role in chemical processes, particularly in reactions involving metal complexes with unpaired electrons. However, more definitive state-to-state experiments are needed to better elucidate the role of electronic spin. Herein, we chose nickel (II) 5,10,15,20-tetrakis(pentafluorophenyl) porphyrin 1 as a catalyst, which allows switching from a low spin to a high spin state of Ni (II) center through an axial pyridine coordination, for electrocatalytic hydrogen evolution reaction (HER). When pyridine is present, we observed β -hydrogenation of porphyrin through electron transfer followed by proton transfer. In contrast, hydrogen evolution mainly occurs via the concerted proton-coupling electron transfer without pyridine coordination. Similar distinct spin-dependent selectivity was also observed in chemical reduction of 1 by CoCp 2 with subsequent addition of pyridinium p -toluenesulfonate. Computational calculations using density functional theory demonstrated that the transition from low spin to high spin state enriches the ligand's electron density after one-electron reduction, leading to preferential protonation of β -periphery rather than mes o-position or metal center.}, archive = {J_ANGEW}, author = {Hao-Zong Xue and Jia-Hui Wu and Bing-Wu Wang and Song Gao and Jun-Long Zhang}, doi = {10.1002/anie.202413042}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413042}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Coordination induced spin state transition switches the reactivity of nickel (II) porphyrin in hydrogen evolution reaction}, volume = {64}, year = {2025}, }
• (2025). Unveiling ionized interfacial water-induced localized h* enrichment for electrocatalytic nitrate reduction. ANGEW, 64(1), e202413033. (www)

  @article{ , abstract = {Electrocatalytic nitrate reduction reaction (NO 3 RR) is a process that requires the participation of eight electrons and nine protons. The regulation of active hydrogen (H*) supply and a deep understanding of related processes are necessary for improving the ammonia yield rate and Faradaic efficiency (FE). Herein, we synthesized a series of atomically precise copper-halide clusters Cu 2 X 2 (BINAP) 2 (X=Cl, Br, I), among which the Cu 2 Cl 2 (BINAP) 2 cluster shows the optimal ammonia FE of 94.0 % and an ammonia yield rate of 373 μmol h −1 cm −2 . In situ experiments and theoretical calculations reveal that halogen atoms, especially Cl in Cu 2 Cl 2 (BIANP) 2 , can significantly affect the distance of alkali metal-ionized water on the catalyst surface, which can promote the water dissociation to enhance the localized H* enrichment for the continues hydrogenation of nitrate to ammonia. This work explains the role of H* in the hydrogenation process of NO 3 RR and the importance of localized H* enrichment strategy for improving the FEs.}, archive = {J_ANGEW}, author = {Su-Jun Zheng and Xiao-Yu Dong and Hong Chen and Ren-Wu Huang and Jinmeng Cai and Shuang-Quan Zang}, doi = {10.1002/anie.202413033}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413033}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Unveiling ionized interfacial water-induced localized h* enrichment for electrocatalytic nitrate reduction}, volume = {64}, year = {2025}, }
• (2025). Solid-liquid-gas three-phase indirect electrolysis enabled by affinity auxiliary imparted covalent organic frameworks. ANGEW, 64(1), e202413030. (www)

  @article{ , abstract = {The design of efficient heterogeneous redox mediators with favorable affinity to substrate and electrolyte are much desired yet still challenging for the development of indirect electrolysis system. Herein, for the first time, we have developed a solid–liquid–gas three-phase indirect electrolysis system based on a covalent organic framework (Dha−COF−Cu) as heterogeneous redox mediator for S−S coupling reaction. Dha−COF−Cu with the integration of high porosity, nanorod morphology, abundant hydroxyl groups and active Cu sites is much beneficial for the adsorption/activation of thiols, uniform dispersion and high wettability in electrolyte, and efficient interfacial electron transfer. Notably, Dha−COF−Cu as solid-phase redox mediator exhibits excellent electrocatalytic efficiency for the formation of value-added liquid-phase S−S bond product (yields up to 99 %) coupling with the generation of gas-phase product of H 2 (~1.40 mmol g −1 h −1 ), resulting in a powerful three-phase indirect electrolysis system. This is the first work about COFs that can be applied in three-phase indirect electrolysis system, which might promote the development of porous crystalline materials in this field.}, archive = {J_ANGEW}, author = {Yi-Rong Wang and Ming Yue and Gang Liu and Jia-Li Zhang and Qi Li and Jing-Wen Shi and Jia-Yong Weng and Run-Han Li and Yifa Chen and Shun-Li Li and Ya-Qian Lan}, doi = {10.1002/anie.202413030}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413030}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solid-liquid-gas three-phase indirect electrolysis enabled by affinity auxiliary imparted covalent organic frameworks}, volume = {64}, year = {2025}, }
• (2025). Halide perovskite induces Halogen/Hydrogen atom transfer (XAT/HAT) for allylic C−H amination. ANGEW, 64(1), e202413012. (www)

  @article{ , abstract = {Allylic C−H amination has emerged as a powerful tool to construct allylamines, common motifs in molecular therapeutics. Such reaction implies an oxidative path for C−H activation but furnishes reductive amines, inferring mild oxidants’ inactivity for C−H oxidation but strong oxidants’ detriment to products. Herein we report a heterogeneous catalytic approach that manipulates halogen-vacancies of perovskite photocatalyst and exploits halogenated-solvents (i.e. CH 2 Cl 2 , CH 2 Br 2 ) as mild oxidants for selective C−H allyl amination with 19,376 turnovers. CsPbBr 3 nanocrystals induce cooperative hydrogen-atom-transfer (HAT, C−H oxidation, and halogen-vacancy CsPbBr 3−x formation) and halogen-atom-transfer (XAT, CsPbBr 3−x -induced solvent reduction) under a radical chain mechanism. Terminal/internal olefins are amenable to forge aromatic/aliphatic, cyclic/acyclic, secondary/tertiary allylamines (70 examples), including drugs or their derivatives.}, archive = {J_ANGEW}, author = {Melad Shaikh and Kevin Rubalcaba and Yong Yan}, doi = {10.1002/anie.202413012}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413012}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Halide perovskite induces Halogen/Hydrogen atom transfer (XAT/HAT) for allylic C−H amination}, volume = {64}, year = {2025}, }
• (2025). Switching CO2 electroreduction pathways between ethylene and ethanol via tuning microenvironment of the coating on copper nanofibers. ANGEW, 64(1), e202413005. (www)

  @article{ , abstract = {Engineering the microenvironment of electrode surface is one of the effective means to tune the reaction pathways in CO 2 RR. In this work, we prepared copper nanofibers with conductive polypyrrole coating by polymerization of pyrrole using polyvinyl pyrrolidone (PVP) as template. As a result, the obtained copper nanofibers Cu/Cu 2+1 O/SHNC, exhibited a superhydrophobic surface, which demonstrated very high selectivity for ethanol with a Faraday efficiency (FE) of 66.5 % at −1.1 V vs reversible hydrogen electrode (RHE) in flow cell. However, the catalyst Cu/Cu 2+1 O/NC, which was prepared under the same conditions but without PVP, possessed a hydrophobic surface and exhibited high selectivity towards ethylene at the given potentials. The mechanism for switch of reaction pathways from ethylene to ethanol in CO 2 RR was studied. Incorporating pyrrolidone groups into the polymer coating results in the formation of a superhydrophobic surface. This surface weakens the hydrogen bonding interaction between interfacial water molecules and facilitates the transfer of CO 2 , thereby enhancing the local CO 2 /H 2 O ratio. The high coverage of *CO promotes the coupling of *CO and *CHO to form C 2 intermediates, and reduces the reaction energy for the formation of *CHCHOH (ethanol path) at the interface. This ensures that the reaction pathway is directed towards ethanol.}, archive = {J_ANGEW}, author = {Xing Tong and Pei Zhang and Peng Chen and Zhuosen He and Xinchen Kang and Yaoyu Yin and Yingying Cheng and Meng Zhou and Lihong Jing and Ce Wang and Baocai Xu and Lirong Zheng and Xueqing Xing and Zhonghua Wu and Buxing Han}, doi = {10.1002/anie.202413005}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413005}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Switching CO2 electroreduction pathways between ethylene and ethanol via tuning microenvironment of the coating on copper nanofibers}, volume = {64}, year = {2025}, }
• (2025). A rationally designed azobenzene photoswitch for DNA G-quadruplex regulation in live cells. ANGEW, 64(1), e202413000. (www)

  @article{ , abstract = {G-quadruplex (G4) DNA structures are increasingly acknowledged as promising targets in cancer research, and the development of G4-specific stabilizing compounds may lay a fundamental foundation in precision medicine for cancer treatment. Here, we propose a light-responsive G4-binder for precise modulation of drug activation, providing dynamic and spatiotemporal control over G4-associated biological processes contributing to cancer cell death. We developed a specialized fluorinated azobenzene (AB) switch equipped with a quinoline unit and a positively charged carboxamide side chain, Q-Azo4F-C , designed for targeted binding to G4 structures within cells. Biophysical studies, combined with molecular dynamics simulations, provide insights into the unique coordination modes of the photoswitchable ligand in its trans and cis configurations when interacting with G4s. The observed variations in complexation processes between the two isomeric states in different cancer cell lines manifest in more than 25-fold reversible cytotoxic activity. Immunostaining conducted with the structure-specific G4 antibody (BG4), establishes a direct correlation between cytotoxicity and the varying extent of G4 induction regulated by the two isoforms. Finally, we demonstrate the photo-driven reversible regulation of G4 structures in lung cancer cells by Q-Azo4F-C . Our findings highlight the potential of light-responsive G4-binders in advancing precision cancer therapy through dynamic control of G4-mediated pathways.}, archive = {J_ANGEW}, author = {Marta Dudek and Lucía López-Pacios and Nasim Sabouri and Juan J. Nogueira and Lara Martinez-Fernandez and Marco Deiana}, doi = {10.1002/anie.202413000}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202413000}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A rationally designed azobenzene photoswitch for DNA G-quadruplex regulation in live cells}, volume = {64}, year = {2025}, }
• (2025). Highly selective synthesis of acetic acid from hydroxyl-mediated oxidation of methane at low temperatures. ANGEW, 64(1), e202412995. (www)

  @article{ , abstract = {Direct methane conversion and, in particular, the aerobic oxidation to acetic acid, remain an eminent challenge. Here, we reported a zeolite-supported Au−Fe catalyst (Au−Fe/ZSM-5) that converted methane to acetic acid with molecular oxygen as an oxidant in the presence of CO. Specifically, Au nanoparticles catalyzed the formation of hydroxyl species from the reaction of CO, O 2 , and H 2 O, meanwhile ZSM-5-supported atomically dispersed Fe species were responsible for the hydroxyl-mediated coupling of CH 4 and CO to generate acetic acid. The reaction over 50 mg of Au−Fe/ZSM-5 under 62 bar (CH 4 : CO : O 2 =14 : 14 : 3) at 120 °C for 3.0 h yielded 5.7 millimoles of acetic acid per gram of the catalyst (mmol g cat −1 ) with the selectivity of 92 %, outperformed most of reported catalysts. Significantly, the catalyst remained active even at 60 °C. We anticipate that this hydroxyl-mediated route may guide the design of optimized catalysts for the direct methane functionalization at low temperatures.}, archive = {J_ANGEW}, author = {Bo Wu and Haibin Yin and Xinlong Ma and Rongjia Liu and Bingxuan He and Hongliang Li and Jie Zeng}, doi = {10.1002/anie.202412995}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412995}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly selective synthesis of acetic acid from hydroxyl-mediated oxidation of methane at low temperatures}, volume = {64}, year = {2025}, }
• (2025). Arenicolide family macrolides provide a new therapeutic lead combating multidrug-resistant tuberculosis. ANGEW, 64(1), e202412994. (www)

  @article{ , abstract = {The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb) poses a significant threat to health globally. During searching for new chemical entities regulating MDR- and XDR-Mtb, chemical investigation of the black oil beetle gut bacterium Micromonospora sp. GR10 led to the discovery of eight new members of arenicolides along with the identification of arenicolide A (Ar−A, 1 ), which was a previously reported macrolide with incomplete configuration. Genomic analysis of the bacterial strain GR10 revealed their putative biosynthetic pathway. Quantum mechanics-based computation, chemical derivatizations, and bioinformatic analysis established the absolute stereochemistry of Ar−A and arenicolides D−K (Ar−D−K, 2 – 9 ) completely for the first time. Biological studies of 1 – 9 revealed their antimicrobial activity against MDR and XDR strains of Mtb. Ar−A had the most potent in vitro antimicrobial efficacy against MDR- and XDR-Mtb. Mechanistically, Ar−A induced ATP depletion and destabilized Mtb cell wall, thereby inhibiting growth. Notably, Ar−A exerted a significant antimicrobial effect against Mtb in macrophages, was effective in the treatment of Mtb infections, and showed a synergistic effect with amikacin (AMK) in a mouse model of MDR-Mtb lung infection. Collectively, our findings indicate Ar−A to be a promising drug lead for drug-resistant tuberculosis.}, archive = {J_ANGEW}, author = {Sunghoon Hwang and Bo Eun Heo and Thanh Quang Nguyen and Young Jae Kim and Sung-Gwon Lee and Thanh-Hau Huynh and Eunji Kim and Shin-Il Jo and Min-Jun Baek and Eun-Kyung Shin and Joonseok Oh and Chungoo Park and Yeo Joon Yoon and Eun-Jin Park and Kyung Tae Kim and Sungweon Ryoo and Da-Gyum Lee and Connor Wood and Minjeong Woo and Dae-Duk Kim and Seungwha Paik and Eun-Kyeong Jo and Jichan Jang and Dong-Chan Oh}, doi = {10.1002/anie.202412994}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412994}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Arenicolide family macrolides provide a new therapeutic lead combating multidrug-resistant tuberculosis}, volume = {64}, year = {2025}, }
• (2025). Revitalizing dead zinc with Ferrocene/Ferrocenium redox chemistry for deep-cycle zinc metal batteries. ANGEW, 64(1), e202412989. (www)

  @article{ , abstract = {Aqueous zinc (Zn) batteries are highly desirable for sustainable and large-scale electrochemical energy storage technologies. However, the ceaseless dendrite growth and the derived dead Zn are principally responsible for the capacity decay and insufficient lifespan. Here, we propose a dissolved oxygen-initiated revitalization strategy to reactivate dead Zn via ferrocene redox chemistry, which can be realized by incorporating a trace amount of poly(ethylene glycol) as a solubilizer to improve the solubility of water-insoluble ferrocene derivatives. Ferrocene scaffold can be spontaneously oxidized to ferricenium cations by dissolved oxygen, which eradicates the dissolved oxygen-involved Zn corrosion and insulating by-product generation. Subsequently, the generated ferricenium cations as the scavenger can rejuvenate electrically isolated dead Zn into electroactive Zn 2+ ions to compensate the zinc loss. Through this design, the symmetric cell exhibited improved cycle life of 3700 h at 10 mA cm −2 , and 220 h under a high depth of discharge of 80 %. Importantly, the Zn||NaV 3 O 8 ⋅ 1.5H 2 O full cells demonstrated the impressive cycling stability over 1500 cycles at a low N/P ratio of 3.0. This work presents an innovative solution for the revitalization of dead Zn to extend the lifespan of deep-cycling metal batteries.}, archive = {J_ANGEW}, author = {Xiaohu Qian and Tao Chen and Yinan Wang and Qianjin Zhang and Wenqi Li and Jiajun Fu}, doi = {10.1002/anie.202412989}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412989}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Revitalizing dead zinc with Ferrocene/Ferrocenium redox chemistry for deep-cycle zinc metal batteries}, volume = {64}, year = {2025}, }
• (2025). Asymmetrified benzothiadiazole-based solid additives enable all-polymer solar cells with efficiency over 19 %. ANGEW, 64(1), e202412983. (www)

  @article{ , abstract = {Disordered polymer chain entanglements within all-polymer blends limit the formation of optimal donor-acceptor phase separation. Therefore, developing effective methods to regulate morphology evolution is crucial for achieving optimal morphological features in all-polymer organic solar cells (APSCs). In this study, two isomers, 4,5-difluorobenzo- c -1,2,5-thiadiazole (SF-1) and 5,6-difluorobenzo- c -1,2,5-thiadiazole (SF-2), were designed as solid additives based on the widely-used electron-deficient benzothiadiazole unit in nonfullerene acceptors. The incorporation of SF-1 or SF-2 into PM6 : PY-DT blend induces stronger molecular packing via molecular interaction, leading to the formation of continuous interpenetrated networks with suitable phase-separation and vertical distribution. Furthermore, after treatment with SF-1 and SF-2, the exciton diffusion lengths for PY-DT films are extended to over 40 nm, favoring exciton diffusion and charge transport. The asymmetrical SF-2, characterized by an enhanced dipole moment, increases the power conversion efficiency (PCE) of PM6 : PY-DT-based device to 18.83 % due to stronger electrostatic interactions. Moreover, a ternary device strategy boosts the PCE of SF-2-treated APSC to over 19 %. This work not only demonstrates one of the best performances of APSCs but also offers an effective approach to manipulate the morphology of all-polymer blends using rational-designed solid additives.}, archive = {J_ANGEW}, author = {Tianqi Chen and Yanyi Zhong and Tainan Duan and Xian Tang and Wenkai Zhao and Jiaying Wang and Guanghao Lu and Guankui Long and Jiangbin Zhang and Kai Han and Xiangjian Wan and Bin Kan and Yongsheng Chen}, doi = {10.1002/anie.202412983}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412983}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Asymmetrified benzothiadiazole-based solid additives enable all-polymer solar cells with efficiency over 19 %}, volume = {64}, year = {2025}, }
• (2025). Rational design of 7-azaindole-based robust microporous hydrogen-bonded organic framework for gas sorption. ANGEW, 64(1), e202412981. (www)

  @article{ , abstract = {7-Azaindole has been integrated as building block with complementary N−H⋅⋅⋅N hydrogen bonding sites for the synthesis of a tetrahedral molecular tecton, namely tetra(α-carbolin-6-yl)methane, TACM. The self-assembly of this molecule results in a 3D hydrogen-bonded organic framework (HOF). This supramolecular structure constitutes a crystalline microporous material with an extraordinary thermal and chemical robustness. Single crystal X-ray diffraction reveals how the five-fold catenation of diamonoid systems, stabilized by hydrogen bonds and π–π interactions, form an interpenetrated network with monodimensional channels. The structural features of the crystalline material are also observed by transmission electron microscopy (TEM). Additionally, the microporosity of the activated TACM-HOF is characterized by gas sorption (N 2 , CO 2 , CH 4 and H 2 ) experiments performed at different pressures. A selective adsorption is observed for CO 2 uptake and TACM-HOF also presents a good adsorption capacity for H 2 among supramolecular organic frameworks.}, archive = {J_ANGEW}, author = {Manuel Carrera and Ion Such-Basáñez and Juan Pablo Marco-Lozar and Agustín Bueno-López and Eduardo Vilaplana-Ortego and Iván da Silva and Delia Bautista and Alberto Fernández-Alarcón and Joaquín Calbo and Enrique Ortí and David Curiel}, doi = {10.1002/anie.202412981}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412981}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Rational design of 7-azaindole-based robust microporous hydrogen-bonded organic framework for gas sorption}, volume = {64}, year = {2025}, }
• (2025). A modular approach for accessing 3D heterocycles via 1,2-dicyanation of planar N-heteroarenes. ANGEW, 64(1), e202412979. (www)

  @article{ , abstract = {The rapid construction of three-dimensional (3D) heterocyclic frameworks is a key challenge in contemporary medicinal chemistry. The molecules with three-dimensional complexity hold a greater probability to improve clinical outcomes, solubility, selectivity for target proteins, and metabolic stability. However, the prevalence of flat molecules persists among new drug candidates, primarily owing to the multitude of chemical methods available for their synthesis. In principle, the dearomative functionalization of N -heteroarene allows for the conversion of readily available planar molecules into partially or fully saturated nitrogen heterocycles, which are most significant structural motifs of pharmaceuticals and natural products. Unfortunately, these reactions are very rare because of the inherent challenge imposed by heteroarenes’ poor reactivity, rendering the process thermodynamically unfavorable. Herein, we report a modular approach for accessing 3D chemical space in translating planar heteroarenes into valuable 3D heterocycles via the installation of a highly versatile cyano group as a new vector. This approach is enabled by the in situ generation of reactive, non-symmetric iodane by combining cyanide anion and bench-stable PhI(OAc) 2 . This reaction represents a rare example of 1,2-dicyanation of N -heteroarenes that meets the numerous requirements for broad implementation in drug and agrochemical discovery. The transformation is highly selective and amenable to a wide range of N -heteroarenes and late-stage partial saturation of drugs and agrochemicals.}, archive = {J_ANGEW}, author = {Sukumar Pradhan and Sudip Maiti and Suparna Dutta and C. Adam Russell and Sameer Tyagi and Debabrata Maiti}, doi = {10.1002/anie.202412979}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412979}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A modular approach for accessing 3D heterocycles via 1,2-dicyanation of planar N-heteroarenes}, volume = {64}, year = {2025}, }
• (2025). Solution versus on-surface synthesis of peripherally oxygen-annulated porphyrins through C−O bond formation. ANGEW, 64(1), e202412978. (www)

  @article{ , abstract = {This study investigates the synthesis of tetra- and octa-O-fused porphyrinoids employing an oxidative O-annulation approach through C−H activation. Despite encountering challenges such as overoxidation and instability in conventional solution protocols, successful synthesis was achieved on Au(111) surfaces under ultra-high vacuum (UHV) conditions. X-ray photoelectron spectroscopy, scanning tunneling microscopy, and non-contact atomic force microscopy elucidated the preferential formation of pyran moieties via C−O bond formation and subsequent self-assembly driven by C−H⋅⋅⋅O interactions. Furthermore, the O-annulation process was found to reduce the HOMO–LUMO gap by lifting the HOMO energy level, with the effect rising upon increasing the number of embedded O-atoms.}, archive = {J_ANGEW}, author = {Joel Deyerling and Beatrice Berionni Berna and Dmytro Biloborodov and Felix Haag and Sena Tömekce and Marc G. Cuxart and Conghui Li and Willi Auwärter and Davide Bonifazi}, doi = {10.1002/anie.202412978}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412978}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Solution versus on-surface synthesis of peripherally oxygen-annulated porphyrins through C−O bond formation}, volume = {64}, year = {2025}, }
• (2025). Highly efficient Red/Near-infrared phosphorescence from doped crystals. ANGEW, 64(1), e202412967. (www)

  @article{ , abstract = {Organic red/near-infrared (NIR) room temperature phosphorescence (RTP) materials with low toxicity and facile synthesis are highly sought after, particularly for applications in biotechnology and encryption. However, achieving efficient red/NIR RTP emitters has been challenging due to the weak spin-orbit coupling of organics and the rapid nonradiative decay imposed by the energy gap law. Here we demonstrate highly efficient red/NIR RTP with boosted quantum yields ( Φ p s) of up to 32.96 % through doping the thionated derivatives of phthalimide (PAI) (MTPAI and DTPAI) into PAI crystals. The red-shifted photoluminescence (PL) stems from a combination of the external heavy atom effect and the formation of emissive clusters centered around electron-rich sulfur atoms. Furthermore, the dopants enhance exciton generation efficiency and facilitate energy transfer from smaller PAI units to larger aggregates, leading to dramatically increased Φ p . This strategy proves universal, opening possibilities for acquiring long-wavelength RTP with tunable photophysical properties. The doped crystals exhibit promising applications in optical waveguides and encryption paper/ink. This research provides a practical approach to obtaining long-wavelength RTP materials and offers valuable insights into the mechanisms governing host-guest systems.}, archive = {J_ANGEW}, author = {Zihao Zhao and Tianwen Zhu and Anze Li and Qiang Zhang and Wang Zhang Yuan}, doi = {10.1002/anie.202412967}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412967}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Highly efficient Red/Near-infrared phosphorescence from doped crystals}, volume = {64}, year = {2025}, }
• (2025). Modulating the inner helmholtz plane towards stable solid electrolyte interphase by anion-π interactions for high-performance anode-free lithium metal batteries. ANGEW, 64(1), e202412955. (www)

  @article{ , abstract = {Anode-free lithium (Li) metal batteries (AFLBs) featured high energy density are viewed as the viable future energy storage technology. However, the irregular Li deposition and unstable solid electrolyte interphase (SEI) on anode current collectors reduce their cycling performance. Here, we propose a concept of anion-recognition electrodes enabled by anion-π interactions to regulate the inner Helmholtz plane (IHP) and electrolyte solvation chemistry for high-performance AFLBs. By engineering the electrodes with electron-deficient aromatic-π systems that possess high permanent quadrupole moment (Q zz ), the anion-π interactions can be generated to concentrate the anions on the electrode surface and tune the IHP structure to construct a stable anion-derived SEI layer, thus achieving highly reversible Li plating/stripping process. Through designing various current collectors with different Q zz values, the intimate correlations among the surface charge of the electrode, competitive adsorption of the IHP, and SEI structures are demonstrated. Particularly, the modified carbon cloth current collector with a high Q zz value (+35.1) delivers a high average Li stripping/plating Coulombic efficiency of 99.1 % over 230 cycles in the carbonated electrolyte, enabling a long lifespan and high capacity retention of LiNi 0.8 Co 0.1 Mn 0.1 O 2 -based AFLBs with a commercial-level areal capacity (4.1 mAh cm −2 ).}, archive = {J_ANGEW}, author = {Shaobo Ma and Jingteng Zhao and Huang Xiao and Qixin Gao and Fang Li and Congying Song and Guoxing Li}, doi = {10.1002/anie.202412955}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412955}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating the inner helmholtz plane towards stable solid electrolyte interphase by anion-π interactions for high-performance anode-free lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Cleavage of homonuclear chalcogen-chalcogen bonds in a hybrid platform in response to X-ray radiation potentiates tumor radiochemotherapy. ANGEW, 64(1), e202412922. (www)

  @article{ , abstract = {Chalcogens are used as sensitive redox-responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than by internal environmental stimuli, enable site-directed and real-time drug degradation in target lesions. This approach helps to bypass chemoresistance and global systemic toxicity, presenting a significant advancement over traditional chemoradiotherapy. In this study, we fabricated a hybrid monodisperse organosilica nanoprodrug based on homonuclear single bonds (disulfide bonds (S−S, approximately 240 kJ/mol), diselenium bonds (Se−Se, approximately 172 kJ/mol), and tellurium bonds (Te−Te, 126 kJ/mol)), including ditelluride-bond-bridged MONs (DTeMSNs), diselenide-bond-bridged MONs (DSeMSNs) and disulfide-bond-bridged MONs (DSMSNs). The results demonstrated that differences in electronegativities and atomic radii influenced their oxidation sensitivities and reactivities. Tellurium, with the lowest electronegativity, showed the highest sensitivity, followed by selenium and sulfur. DTeMSNs exhibited highly responsive cleavage upon exposure to X-rays, resulting in oxidation to TeO 3 2− . Furthermore, chalcogen-hybridized organosilica was loaded with manganese ions (Mn 2+ ) to enhance the release of Mn 2+ during radiotherapy, thereby activating the the stimulator of interferon genes (STING) pathway and enhancing the tumor immune response to inhibit tumor growth. This investigation of hybrid organosilica deepens our understanding of chalcogens response characteristics to radiotherapy and enriches the design principles for nanomedicine based on prodrugs.}, archive = {J_ANGEW}, author = {Yuanyuan You and Yanzhou Chang and Shuya Pan and Qingyue Bu and Jiabao Ling and Weiling He and Tianfeng Chen}, doi = {10.1002/anie.202412922}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412922}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Cleavage of homonuclear chalcogen-chalcogen bonds in a hybrid platform in response to X-ray radiation potentiates tumor radiochemotherapy}, volume = {64}, year = {2025}, }
• (2025). Regulating intermolecular interactions and film formation kinetics for record efficiency in difluorobenzothiadizole-based organic solar cells. ANGEW, 64(1), e202412903. (www)

  @article{ , abstract = {The difluorobenzothiadizole (ffBT) unit is one of the most classic electron-accepting building blocks used to construct D-A copolymers for applications in organic solar cells (OSCs). Historically, ffBT-based polymers have achieved record power conversion efficiencies (PCEs) in fullerene-based OSCs owing to their strong temperature-dependent aggregation (TDA) characteristics. However, their excessive miscibility and rapid aggregation kinetics during film formation have hindered their performance with state-of-the-art non-fullerene acceptors (NFAs). Herein, we synthesized two ffBT-based copolymers, PffBT-2T and PffBT-4T, incorporating different π-bridges to modulate intermolecular interactions and aggregation tendencies. Experimental and theoretical studies revealed that PffBT-4T exhibits reduced electrostatic potential differences and miscibility with L8-BO compared to PffBT-2T. This facilitates improved phase separation in the active layer, leading to enhanced molecular packing and optimized morphology. Moreover, PffBT-4T demonstrated a prolonged nucleation and crystal growth process, leading to enhanced molecular packing and optimized morphology. Consequently, PffBT-4T-based devices achieved a remarkable PCE of 17.5 %, setting a new record for ffBT-based photovoltaic polymers. Our findings underscore the importance of conjugate backbone modulation in controlling aggregation behavior and film formation kinetics, providing valuable insights for the design of high-performance polymer donors in organic photovoltaics.}, archive = {J_ANGEW}, author = {Zhibo Wang and Shenbo Zhu and Xiaoxiao Peng and Siwei Luo and Wenting Liang and Ziyue Zhang and Yunjie Dou and Guangye Zhang and Shangshang Chen and Huawei Hu and Yiwang Chen}, doi = {10.1002/anie.202412903}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412903}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating intermolecular interactions and film formation kinetics for record efficiency in difluorobenzothiadizole-based organic solar cells}, volume = {64}, year = {2025}, }
• (2025). Molecular iridium catalyzed electrochemical formic acid oxidation: Mechanistic insights. ANGEW, 64(1), e202412901. (www)

  @article{ , abstract = {Electrochemical formic acid oxidation reaction (FAOR) is a pivotal model for understanding organic fuel oxidation and advancing sustainable energy technologies. Here, we present mechanistic insights into a novel molecular-like iridium catalyst (Ir−N 4 −C) for FAOR. Our studies reveal that isolated sites facilitate a preferential dehydrogenation pathway, circumventing catalyst poisoning and exhibiting high inherent activity. In situ spectroscopic analyses elucidate that weakly adsorbed intermediates mediate the FAOR and are dynamically regulated by potential-dependent redox transitions. Theoretical and experimental investigations demonstrate a parallel mechanism involving two key intermediates with distinct pH and potential sensitivities. The rate-determining step is identified as the adsorption of formate via coupled or sequential proton-electron transfer, which aligns well with the observed kinetic properties, pH dependence, and hydrogen/deuterium isotope effects in experiments. These findings provide valuable insights into the reaction mechanism of FAOR, advancing our understanding at the molecular level and potentially guiding the design of efficient catalysts for fuel cells and electrolyzers.}, archive = {J_ANGEW}, author = {Yuzhu Zhou and Wenjie Xu and Zhen Wei and Dong Tian and Baiquan Zhu and Sicong Qiao and Yanxia Chen and Qun He and Li Song}, doi = {10.1002/anie.202412901}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412901}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Molecular iridium catalyzed electrochemical formic acid oxidation: Mechanistic insights}, volume = {64}, year = {2025}, }
• (2025). Regulating non-equilibrium solvation structure in locally concentrated ionic liquid electrolytes for wide-temperature and high-voltage lithium metal batteries. ANGEW, 64(1), e202412896. (www)

  @article{ , abstract = {The development of high-voltage lithium metal batteries (LMBs) encounters significant challenges due to aggressive electrode chemistry. Recently, locally concentrated ionic liquid electrolytes (LCILEs) have garnered attention for their exceptional stability with both Li anodes and high-voltage cathodes. However, there remains a limited understanding of how diluents in LCILEs affect the thermodynamic stability of the solvation structure and transportation dynamics of Li + ions. Herein, we propose a wide-temperature LCILEs with 1,3-dichloropropane (DCP13) diluent to construct a non-equilibrium solvation structure under external electric field, wherein the DCP13 diluent enters the Li + ion solvation sheath to enhance Li + ion transport and suppress oxidative side reactions at high-nickel cathode (LiNi 0.9 Co 0.05 Mn 0.05 O 2 , NCM90). Consequently, a Li/NCM90 cell utilizing this LCILE achieves a high capacity retention of 94 % after 240 cycles at 4.3 V, also operates stably at high cut-off voltages from 4.4 V to 4.6 V and over a wide temperature range from −20 °C to 60 °C. Additionally, an Ah-level pouch cell with this LCILE simultaneously achieves high-energy-density and stable cycling, manifesting the practical feasibility. This work redefines the role of diluents in LCILEs, providing inspiration for electrolyte design in developing high-energy-density batteries.}, archive = {J_ANGEW}, author = {Haifeng Tu and Zhicheng Wang and Jiangyan Xue and Zhiyong Tang and Yang Liu and Xiaofang Liu and Lingwang Liu and Suwan Lu and Shixiao Weng and Yiwen Gao and Guochao Sun and Zheng Liu and Keyang Peng and Xin Zhang and Dejun Li and Guangye Wu and Meinan Liu and Jianchen Hu and Hong Li and Jingjing Xu and Xiaodong Wu}, doi = {10.1002/anie.202412896}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412896}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Regulating non-equilibrium solvation structure in locally concentrated ionic liquid electrolytes for wide-temperature and high-voltage lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Three-dimensional covalent organic frameworks based on linear and trigonal linkers for high-performance H2O2 photosynthesis. ANGEW, 64(1), e202412890. (www)

  @article{ , abstract = {The design of three-dimensional covalent organic frameworks (3D COFs) using linear and trigonal linkers remains challenging due to the difficulty in achieving a specific non-planar spatial arrangement with low-connectivity building units. Here, we report the novel 3D COFs with linear and trigonal linkers, termed TMB-COFs, exhibiting srs topology. The steric hindrance provides an additional force to alter the torsion angles of peripheral triangular units, guiding the linear unit to connect with the trigonal unit into 3D srs frameworks, rather than the more commonly observed two-dimensional (2D) hcb structures. Furthermore, we comprehensively examined the hydrogen peroxide photocatalytic production capacity of the TMB-COFs in comparison with analogous 2D COFs. The experimental results and DFT calculations demonstrate a significant enhancement in photocatalytic hydrogen peroxide production efficacy through framework regulation. This work emphasizes the steric configuration using low connectivity building units, offering a fresh perspective on the design and application of 3D COFs.}, archive = {J_ANGEW}, author = {Ruo-Meng Zhu and Yong Liu and Wang-Kang Han and Jing-Dong Feng and Jinfang Zhang and Huan Pang and Jiangwei Zhang and Zhi-Guo Gu}, doi = {10.1002/anie.202412890}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412890}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Three-dimensional covalent organic frameworks based on linear and trigonal linkers for high-performance H2O2 photosynthesis}, volume = {64}, year = {2025}, }
• (2025). Nacre-inspired structure enables ultrahigh ‘Strong-tough’ design of phosphorus anode. ANGEW, 64(1), e202412867. (www)

  @article{ , abstract = {Red phosphorus anode, attributed to its high specific capacity of 2596 mAh g −1 , is expected to improve the energy density of Na-ion batteries. However, the P anode currently is unsatisfactory for practical usage due to the large volume expansion beyond 300 %, which brings out uncontrolled brittle failure. To address this challenge, we here design a nacre-like phosphorus anode by resilient graphene oxide staggered together. The staggered structure simultaneously offers mechanical strength and interwoven toughness. Finite element modeling reveals that the sodiation stress from P nanoparticles will be transferred into interlayer pillars as the elastic medium to release sodiation stress. The prepared anode achieves an ultrahigh areal capacity of 13 mAh cm −2 at a mass loading of 5.8 mg cm −2 . Notably, the volume change of the anode is limited to approximately 8.1 % at full sodiation, significantly lower than that of the traditional phosphorus electrodes.}, archive = {J_ANGEW}, author = {Baoyu Sun and Shuai Wang and Caiwang Mao and Rui Qiao and Mahalingam Ravivarma and Shude Liu and Hao Fan and Jingying Xie and Jiangxuan Song}, doi = {10.1002/anie.202412867}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412867}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Nacre-inspired structure enables ultrahigh ‘Strong-tough’ design of phosphorus anode}, volume = {64}, year = {2025}, }
• (2025). Non-fluorinated cyclic ether-based electrolyte with quasi-conjugate effect for high-performance lithium metal batteries. ANGEW, 64(1), e202412859. (www)

  @article{ , abstract = {Fluorinated ether-based electrolytes are commonly employed in lithium metal batteries (LMBs) to attenuate the coordination ability of ether solvents with Li + and induce inorganic-rich interphase, whereas fluorination inevitably introduces exorbitant production expenses and environmental anxieties. Herein, a non-fluorinated molecular design strategy has been conceptualized by incorporating methoxy as an electron-donating group to generate a quasi-conjugate effect for tuning the affinity of Li + -solvent, thereby enabling the cyclic ether solvent 2-methoxy-1,3-dioxolane with weak solvation ability and exceptional Li metal-compatibility. Accordingly, the optimized electrolyte exhibits anion-dominant solvation structure for inorganic-rich interphase and fulfills an impressive Li plating/stripping Coulombic efficiency of 99.6 %. As-fabricated Li||LiFePO 4 full cells with limited Li (N/P=2.5) showcase a high capacity retention of 83 % after 150 cycles, indicating excellent cycling stability. Moreover, the full LMBs demonstrate exceptional tolerance towards a wide temperature range from −20 °C to 60 °C, displaying a remarkable capacity retention of 90 % after 110 cycles at −20 °C. Such a molecular design strategy offers a promising avenue for electrolyte engineering beyond fluorination in order to cultivate high-performance LMBs.}, archive = {J_ANGEW}, author = {Xiao Zhu and Jiawei Chen and Gaopan Liu and Yanbing Mo and Yihua Xie and Kang Zhou and Yonggang Wang and Xiaoli Dong}, doi = {10.1002/anie.202412859}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412859}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Non-fluorinated cyclic ether-based electrolyte with quasi-conjugate effect for high-performance lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). A dynamically ion-sieved electrolyte towards ultralong-lifespan zn-ion batteries. ANGEW, 64(1), e202412853. (www)

  @article{ , abstract = {The practical deployment of Zn-ion batteries faces challenges such as dendrite growth, side reactions and cathode dissolution in traditional electrolytes. Here, we develop a highly conductive and dynamically ion-sieved electrolyte to simultaneously enhance the Zn metal reversibility and suppress the cathode dissolution. The dynamic ion screen at the electrode/electrolyte interface is achieved by numerous pyrane rings with a radius of 3.69 Å, which can selectively facilitate the plating/stripping and insertion/extraction process of [Zn(H 2 O) 6 ] 2+ and Zn 2+ on the anode and cathode surfaces. As a proof of concept, Zn//Zn symmetric cells deliver exceptional cyclic stability for over 6,800 h and ultrahigh cumulative plated capacity of 1.95 Ah cm −2 . Zn//Na 2 Mn 3 O 7 cells exhibit satisfactory cycling performance with capacity retention of 82.7 % after 4,000 cycles, and the assembled pouch cells achieve excellent stability and durability. This work provides valuable insights into the development of electrolytes aimed at enhancing the interface stability of aqueous batteries.}, archive = {J_ANGEW}, author = {Yuyao Ji and Qiang Hu and Jingxin Zhao and Cuiping Han and Hui-Ming Cheng}, doi = {10.1002/anie.202412853}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412853}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A dynamically ion-sieved electrolyte towards ultralong-lifespan zn-ion batteries}, volume = {64}, year = {2025}, }
• (2025). Manufacturing single-atom alloy catalysts for selective CO2 hydrogenation via refinement of isolated-alloy-islands. ANGEW, 64(1), e202412835. (www)

  @article{ , abstract = {Single-atom alloy (SAA) catalysts exhibit huge potential in heterogeneous catalysis. Manufacturing SAAs requires complex and expensive synthesis methods to precisely control the atomic scale dispersion to form diluted alloys with less active sites and easy sintering of host metal, which is still in the early stages of development. Here, we address these limitations with a straightforward strategy from a brand-new perspective involving the ‘islanding effect’ for manufacturing SAAs without dilution: homogeneous RuNi alloys were continuously refined to highly dispersed alloy-islands (~1 nm) with completely single-atom sites where the relative metal loading was as high as 40 %. Characterized by advanced atomic-resolution techniques, single Ru atoms were bonded with Ni as SAAs with extraordinary long-term stability and no sintering of the host metal. The SAAs exhibited 100 % CO selectivity, over 55 times reverse water-gas shift (RWGS) rate than the alloys with Ru cluster sites, and over 3–4 times higher than SAAs by the dilution strategy. This study reports a one-step manufacturing strategy for SAA's using the wetness impregnation method with durable high atomic efficiency and holds promise for large-scale industrial applications.}, archive = {J_ANGEW}, author = {Sibei Zou and Yuhang Liang and Xingmo Zhang and Qinfen Gu and Lizhuo Wang and Haoyue Sun and Xiaozhou Liao and Jun Huang and Assaad R. Masri}, doi = {10.1002/anie.202412835}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412835}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Manufacturing single-atom alloy catalysts for selective CO2 hydrogenation via refinement of isolated-alloy-islands}, volume = {64}, year = {2025}, }
• (2025). Modulating the leverage relationship in nitrogen fixation through hydrogen-bond-regulated proton transfer. ANGEW, 64(1), e202412830. (www)

  @article{ , abstract = {In the electrochemical nitrogen reduction reaction (NRR), a leverage relationship exists between NH 3 -producing activity and selectivity because of the competing hydrogen evolution reaction (HER), which means that high activity with strong protons adsorption causes low product selectivity. Herein, we design a novel metal-organic hydrogen bonding framework (MOHBF) material to modulate this leverage relationship by a hydrogen-bond-regulated proton transfer pathway. The MOHBF material was composited with reduced graphene oxide (rGO) to form a Ni-N 2 O 2 molecular catalyst (Ni-N 2 O 2 /rGO). The unique structure of O atoms in Ni-O-C and N-O-H could form hydrogen bonds with H 2 O molecules to interfere with protons being directly adsorbed onto Ni active sites, thus regulating the proton transfer mechanism and slowing the HER kinetics, thereby modulating the leverage relationship. Moreover, this catalyst has abundant Ni-single-atom sites enriched with Ni-N/O coordination, conducive to the adsorption and activation of N 2 . The Ni-N 2 O 2 /rGO exhibits simultaneously enhanced activity and selectivity of NH 3 production with a maximum NH 3 yield rate of 209.7 μg h −1 mg cat. −1 and a Faradaic efficiency of 45.7 %, outperforming other reported single-atom NRR catalysts.}, archive = {J_ANGEW}, author = {Shaoce Zhang and Hu Hong and Rong Zhang and Zhiquan Wei and Yiqiao Wang and Dong Chen and Chuan Li and Pei Li and Huilin Cui and Yue Hou and Shengnan Wang and Johnny C. Ho and Ying Guo and Zhaodong Huang and Chunyi Zhi}, doi = {10.1002/anie.202412830}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412830}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Modulating the leverage relationship in nitrogen fixation through hydrogen-bond-regulated proton transfer}, volume = {64}, year = {2025}, }
• (2025). Enhancing efficiency and stability of inverted perovskite solar cells through solution-processed and structurally ordered fullerene. ANGEW, 64(1), e202412819. (www)

  @article{ , abstract = {The electron transporting layer (ETL) used in high performance inverted perovskite solar cells (PSCs) is typically composed of C 60 , which requires time-consuming and costly thermal evaporation deposition, posing a significant challenge for large-scale production. To address this challenge, herein, we present a novel design of solution-processible electron transporting material (ETM) by grafting a non-fullerene acceptor fragment onto C 60 . The synthesized BTPC 60 exhibits an exceptional solution processability and well-organized molecular stacking pattern, enabling the formation of uniform and structurally ordered film with high electron mobility. When applied as ETL in inverted PSCs, BTPC 60 not only exhibits excellent interfacial contact with the perovskite layer, resulting in enhanced electron extraction and transfer efficiency, but also effectively passivates the interfacial defects to suppress non-radiative recombination. Resultant BTPC 60 -based inverted PSCs deliver an impressive power conversion efficiency (PCE) of 25.3 % and retain almost 90 % of the initial values after aging at 85 °C for 1500 hours in N 2 . More encouragingly, the solution-processed BTPC 60 ETL demonstrates remarkable film thickness tolerance, and enables a high PCE up to 24.8 % with the ETL thickness of 200 nm. Our results highlight BTPC 60 as a promising solution-processed fullerene-based ETM, opening an avenue for improving the scalability of efficient and stable inverted PSCs.}, archive = {J_ANGEW}, author = {Xianglang Sun and Chunlei Zhang and Danpeng Gao and Xinyu Yu and Bo Li and Xin Wu and Shoufeng Zhang and Yaxin He and Zexin Yu and Liangchen Qian and Jianqiu Gong and Shuai Li and Nan Li and Zonglong Zhu and Zhong'an Li}, doi = {10.1002/anie.202412819}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412819}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhancing efficiency and stability of inverted perovskite solar cells through solution-processed and structurally ordered fullerene}, volume = {64}, year = {2025}, }
• (2025). A highly tumor-permeating DNA nanoplatform for efficient remodeling of immunosuppressive tumor microenvironments. ANGEW, 64(1), e202412804. (www)

  @article{ , abstract = {The immunosuppressive tumor microenvironment and limited intratumoral permeation have largely constrained the outcome of tumor therapy. Herein, we report a tailored DNA structure-based nanoplatform with striking tumor-penetrating capability for targeted remodeling of the immunosuppressive tumor microenvironment in vivo. In our design, chemo-immunomodulator (gemcitabine) can be precisely grafted on DNA sequences through a reactive oxygen species (ROS)-sensitive linker. After self-assembly, the gemcitabine-grafted DNA structure can site-specifically organize legumain-activatable melittin pro-peptide (promelittin) on each vertex for intratumoral delivery and further function as the template to load photosensitizers (methylene blue) for ROS production. The tailored DNA nanoplatform can achieve targeted accumulation, highly improved intratumoral permeation, and efficient immunogenic cell death of tumor cells by laser irradiation. Finally, the immunosuppressive tumor microenvironment can be successfully remodeled by reducing multi-type immunosuppressive cells and enhancing the infiltration of cytotoxic lymphocytes in the tumor. This rationally developed multifunctional DNA nanoplatform provides a new avenue for the development of tumor therapy.}, archive = {J_ANGEW}, author = {Hong Wang and Changping Yang and Tiantian Wu and Jing Fan and Hanyin Zhu and Jianbing Liu and Baoquan Ding}, doi = {10.1002/anie.202412804}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412804}, shortjournal = {Angew. Chem. Int. Edit.}, title = {A highly tumor-permeating DNA nanoplatform for efficient remodeling of immunosuppressive tumor microenvironments}, volume = {64}, year = {2025}, }
• (2025). Enhanced visible-light-driven photocatalytic overall splitting of pure water in a porous microreactor. ANGEW, 64(1), e202412796. (www)

  @article{ , abstract = {Photocatalytic overall splitting of pure water (H 2 O) without sacrificial reagent to hydrogen (H 2 ) and oxygen (O 2 ) holds a great potential for achieving carbon neutrality. Herein, by anchoring cobalt sulfide (Co 9 S 8 ) as cocatalyst and cadmium sulfide (CdS) as light absorber to channel wall of a porous polymer microreactor (PP12), continuous violent H 2 and O 2 bubbling productions from photocatalytic overall splitting of pure H 2 O without sacrificial reagent is achieved, with H 2 and O 2 production rates as high as 4.41 and 2.20 mmol h −1 g cat. −1 respectively. These are significantly enhanced than those in the widely used stirred tank-type reactor in which no O 2 is produced and H 2 production rate is only 0.004 mmol h −1 g cat. −1 . Besides improved charge separation and interaction of H 2 O with photocatalyst in PP12, bonding interaction of Co 9 S 8 with PP12 creates abundant catalytic active sites for simultaneous productions of H 2 and O 2 , thus leading to the significantly enhanced H 2 and O 2 bubbling productions in PP12. This offers a new strategy to enhance photocatalytic overall splitting of pure H 2 O without sacrificial reagent.}, archive = {J_ANGEW}, author = {Chuansong Duanmu and Tingwei Wang and Xin-Yu Meng and Jin-Jin Li and Yin-Ning Zhou and Yun-Xiang Pan}, doi = {10.1002/anie.202412796}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412796}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Enhanced visible-light-driven photocatalytic overall splitting of pure water in a porous microreactor}, volume = {64}, year = {2025}, }
• (2025). Multi-scale hierarchical organic photocatalytic platform for self-suspending sacrificial hydrogen production from seawater. ANGEW, 64(1), e202412794. (www)

  @article{ , abstract = {The widespread application of photocatalysis for converting solar energy and seawater into hydrogen is generally hindered by limited catalyst activity and the lack of sustainable large-scale platforms. Here, a multi-scale hierarchical organic photocatalytic platform was developed, combining a photosensitive molecular heterojunction with a molecular-scale gradient energy level alignment and micro-nanoscale hierarchical pore structures. The ternary system facilitates efficient charge transfer and enhances photocatalytic activity compared to conventional donor-acceptor pairs. Meanwhile, the super-wetted hierarchical interfaces of the platform endow it with the ability to repeatedly capture light and self-suspend below the water surface, which simultaneously improves the light utilization efficiency, and reduces the adverse effects of salt deposition. Under a Xe lamp illumination, the hydrogen evolution rate of this organic platform utilizing a sacrificial agent can reach 165.8 mmol h −1 m −2 , exceeding that of mostly inorganic systems as reported. And upon constructing a scalable system, the platform produced 80.6 ml m −2 of hydrogen from seawater within five hours at noon. More importantly, the outcomes suggest an innovative multi-scale approach that bridges disciplines, advancing the frontier of sustainable seawater hydrogen production driven by solar energy.}, archive = {J_ANGEW}, author = {Jingshuai Zhu and Jie Dang and Haoyuan Xiao and Yuqi Wang and Lei Ding and Jiaxin Zheng and Jianming Chen and Jianxiang Zhang and Xungai Wang and John H. Xin and Shiguo Chen and Yuanfeng Wang}, doi = {10.1002/anie.202412794}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412794}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Multi-scale hierarchical organic photocatalytic platform for self-suspending sacrificial hydrogen production from seawater}, volume = {64}, year = {2025}, }
• (2025). Photomodulation of charge transfer through excited-state processes: Directing donor-acceptor binding dynamics. ANGEW, 64(1), e202412790. (www)

  @article{ , abstract = {Modulating charge transfer (CT) interactions between donor and acceptor molecules may give rise to unique dynamic changes in physicochemical properties, exhibiting great importance in supramolecular chemistry and materials science. In this work, we demonstrate the first instance of reversible photomodulation of donor-acceptor (D−A) CT interaction in the solid state. Pyridinium-based chromophore featuring π-conjugated D−A structures can not only function as a good electron acceptor to undergo photoinduced electron transfer (ET) or engage in intermolecular CT interaction, but also exhibit unique dual emission depending on the excitation wavelengths. The rotatable C−C single bonds within D−A pairs enhance the tunability of molecular structure. Through the synergy of a photoinduced ET and an excited-state conformational change, the intermolecular CT interaction can be switched on and off by alternate light irradiation to enable reversibly modulation of the affinity between donor and acceptor molecules, accompanied by visual color switching and fluorescence on-off as feedback signals.}, archive = {J_ANGEW}, author = {Jia-Qi Pan and Hao-Ran Wei and Yun-Rui Chen and Meng-Ze Jia and Bin Tan and Jie Zhang}, doi = {10.1002/anie.202412790}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412790}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Photomodulation of charge transfer through excited-state processes: Directing donor-acceptor binding dynamics}, volume = {64}, year = {2025}, }
• (2025). Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode. ANGEW, 64(1), e202412786. (www)

  @article{ , abstract = {Protein kinases are key regulators of numerous biological processes and aberrant kinase activity can cause various diseases, particularly cancer. Herein, we report the identification of new series of highly selective kinase inhibitors based on the thieno[3,2- b ]pyridine scaffold. The weak interaction of the thieno[3,2- b ]pyridine core with the kinase hinge region allows for profoundly different binding modes all of which maintain high kinome-wide selectivity, as illustrated by the isomers MU1464 and MU1668 . Thus, this core structure provides a template of ATP-competitive but not ATP-mimetic inhibitors that are anchored at the kinase back pocket. Mapping the chemical space around the central thieno[3,2- b ]pyridine pharmacophore afforded highly selective inhibitors of the kinase Haspin, exemplified by the compound MU1920 that fulfils criteria for a quality chemical probe and is suitable for use in in vivo applications. However, despite the role of Haspin in mitosis, the inhibition of Haspin alone was not sufficient to elicit cytotoxic effect in cancer cells. The thieno[3,2- b ]pyridine scaffold can be used in a broader context, as a basis of inhibitors targeting other underexplored protein kinases, such as CDKLs.}, archive = {J_ANGEW}, author = {Paula Martín Moyano and Tadeáš Kubina and Štěpán Owen Paruch and Aneta Jarošková and Jan Novotný and Veronika Skočková and Petra Ovesná and Tereza Suchánková and Polina Prokofeva and Bernhard Kuster and Michal Šmída and Apirat Chaikuad and Andreas Krämer and Stefan Knapp and Karel Souček and Kamil Paruch}, doi = {10.1002/anie.202412786}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412786}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode}, volume = {64}, year = {2025}, }
• (2025). Visible-light photodetection by zero-dimensional hybrid indium-halide with minimal structural distortion and reduced band gap. ANGEW, 64(1), e202412779. (www)

  @article{ , abstract = {Perovskite-inspired zero-dimensional (0D) hybrid halides exhibit impressive light emission properties; however, their potential in photovoltaics is hindered by the absence of interconnection between the inorganic polyhedra, leading to acute radiative recombination and insufficient charge separation. We demonstrate that incorporating closely-spaced dissimilar polyhedral units with minimal structural distortion leads to a remarkable enhancement in visible-light photodetection capability. We designed 0D C 24 H 72 N 8 In 2 Br 14 (HIB) with a tetragonal crystal system, replacing the Cs + of Cs 2 InBr 5 .H 2 O (CIB) with 1,6-hexanediammonium (HDA) cation. HIB comprises [InBr 6 ] 3− octahedra, and [InBr 4 ] − tetrahedra units spaced 3.9 Å apart by the HDA linker. The [InBr 4 ] − unit is additionally linked to HDA via intercalated bromine through hydrogen and halogen bonding interactions, respectively. This structural arrangement lowers the dielectric confinement, thereby enhancing carrier density and mobility, and increasing the diffusion coefficient compared to CIB. With 3.6 % bromine vacancy within the [InBr 4 ] − block, mid-gap states are created, reducing the direct band gap to 2.19 eV. HIB demonstrates an unprecedently high responsivity of 9975.9±201.6 mA W −1 under 3 V potential bias at 485 nm wavelength, among low-dimensional hybrid halides. In the absence of potential bias, the self-powered photodetection parameters are 81.2±3.0 mA W −1 and (6.98±0.21)×10 9 Jones.}, archive = {J_ANGEW}, author = {Anamika Mondal and Mohammad Ubaid and Shresth Gupta and Koushik Pal and Sayan Bhattacharyya}, doi = {10.1002/anie.202412779}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412779}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Visible-light photodetection by zero-dimensional hybrid indium-halide with minimal structural distortion and reduced band gap}, volume = {64}, year = {2025}, }
• (2025). Polyelectrolyte additive-modulated interfacial microenvironment boosting CO2 electrolysis in acid. ANGEW, 64(1), e202412754. (www)

  @article{ , abstract = {Acidic CO 2 electrolysis offers a promising strategy to achieve high carbon utilization and high energy efficiency. However, challenges still remain in suppressing the competitive hydrogen evolution reaction (HER) and improving product selectivity. Although high concentrations of potassium ions (K + ) can suppress HER and accelerate CO 2 reduction, they still inevitably suffer from salt precipitation problems. In this study, we demonstrate that the sulfonate-based polyelectrolyte, polystyrene sulfonate (PSS), enables to reconstruct the electrode-electrolyte interface to significantly enhance the acidic CO 2 electrolysis. Mechanistic studies reveal that PSS induces high local K + concentrations through the electrostatic interaction between PSS anions and K + . In situ spectroscopy reveals that PSS reshapes the interfacial hydrogen–bond (H-bond) network, which is attributed to the H-bonds between PSS anions and hydrated proton, as well as the steric hindrance of the additive molecules. This greatly weakens proton transfer kinetics and leads to the suppression of undesirable HER. As a result, a Faradaic efficiency of 93.9 % for CO can be achieved at 250 mA cm −2 , simultaneous with a high single-pass carbon efficiency of 72.2 % on commercial Ag catalysts in acid. This study highlights the important role of the electrode-electrolyte interface induced by polyelectrolyte additives in promoting electrocatalytic reactions.}, archive = {J_ANGEW}, author = {Anqi Wang and Wangxin Ge and Wen Sun and Xuedi Sheng and Lei Dong and Wenfei Zhang and Hongliang Jiang and Chunzhong Li}, doi = {10.1002/anie.202412754}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412754}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Polyelectrolyte additive-modulated interfacial microenvironment boosting CO2 electrolysis in acid}, volume = {64}, year = {2025}, }
• (2025). Helmholtz plane regulation empowers PF6− permselectivity towards high coulombic efficiency dual ion battery of 5.5 v. ANGEW, 64(1), e202412753. (www)

  @article{ , abstract = {High-voltage dual ion battery (DIB) is promising for stationary energy storage applications owing to its cost-effectiveness, which has been a hot topic of research in rechargeable battery fields. However, it still suffers from rapid battery failure caused by the severe solvent co-intercalation and electrolyte oxidation. To address these bottlenecks, herein a functional electrolyte additive hexafluoroglutaric anhydride (HFGA) is presented based on a Helmholtz plane regulation strategy. It is demonstrated that the HFGA can precisely enter into the Helmholtz plane and positively regulate anion solvation behaviors near the graphite electrode surface owing to its considerable H−F affinity with ethyl methyl carbonate (EMC), thus alleviating EMC-related co-intercalation and oxidation decomposition during DIB charging. Meanwhile, HFGA can copolymerize with the presence of PF 5 at the Helmholtz plane to participate in forming a CF 2 -rich CEI layer with excellent PF 6 − permselectivity, conducive to achieving PF 6 − de-solvation and simultaneously suppressing electrolyte oxidation decomposition. By virtue of such beneficial effects, the graphite cathode enables a 5.5 V DIB with a prominent capacity retention of 92 % and a high average Coulombic efficiency exceeding 99 % within 2000 cycles at 5 C, demonstrating significantly enhanced electrochemical reversibility. The Helmholtz plane regulation strategy marks a milestone in advancing DIB technologies.}, archive = {J_ANGEW}, author = {Xiaoqi Han and Hongzhu Jiang and Pengzhou Mu and Wenjun Zhang and Huanrui Zhang and Gaojie Xu and Zheng Chen and Pengxian Han and Guanglei Cui}, doi = {10.1002/anie.202412753}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412753}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Helmholtz plane regulation empowers PF6− permselectivity towards high coulombic efficiency dual ion battery of 5.5 v}, volume = {64}, year = {2025}, }
• (2025). Curvature-induced electron spin catalysis with carbon spheres. ANGEW, 64(1), e202412745. (www)

  @article{ , abstract = {Here, we report curvature-induced electron spin catalysis by using solid carbon spheres as catalysts, which were synthesized using positive curvature molecular hexabromocyclopentadiene as a precursor molecule, following a radical coupling mechanism. The curvature spin of carbon is regarded as an overlapping state of σ- and π-radical, which is identified by the inverse Laplace transform of pulse-electron paramagnetic resonance. The growth mechanism of carbon spheres abiding by Kroto's model, is supported by the density functional theory study of thermodynamics and kinetics calculations. The solid carbon spheres present excellent catalytic behaviour of oxidation coupling of amines to form corresponding imines with the conversion of >99 %, selectivity of 98.7 %, and yield of 97.7 %, which is attributed to the predominantly curvature-induced electron spin catalysis of carbon, supported by the calculation of oxygen adsorption energy. This work proposes a view of curvature-induced spin catalysis of carbon, which opens up a research direction for curvature-induced electron spin catalysis.}, archive = {J_ANGEW}, author = {Zirui Qiao and Huaqiang Cao and Jiadao Wang and Haijun Yang and Wenqing Yao and Jiaou Wang and Anthony K. Cheetham}, doi = {10.1002/anie.202412745}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412745}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Curvature-induced electron spin catalysis with carbon spheres}, volume = {64}, year = {2025}, }
• (2025). Lighting up bispyrene-functionalized chiral molecular muscles with switchable circularly polarized excimer emissions. ANGEW, 64(1), e202412548. (www)

  @article{ , abstract = {Aiming at the further extension of the application scope of traditional molecular muscles, a novel bispyrene-functionalized chiral molecular [c2]daisy chain was designed and synthesized. Taking advantage of the unique dimeric interlocked structure of molecular [c2]daisy chain, the resultant chiral molecular muscle emits strong circularly polarized luminescence (CPL) attributed to the pyrene excimer with a high dissymmetry factor ( g lum ) value of 0.010. More importantly, along with the solvent- or anion- induced motions of the chiral molecular muscle, the precise regulation of the pyrene stacking within its skeleton results in the switching towards either “inversed” state with sign inversion and larger g lum values or “down ” state with maintained handedness and smaller g lum values, making it a novel multistate CPL switch. As the first example of chiral molecular muscle-based CPL switch, this proof-of-concept study not only successfully widens the application scopes of molecular muscles, but also provides a promising platform for the construction of novel smart chiral luminescent materials for practical applications.}, archive = {J_ANGEW}, author = {Xue Li and Wei-Tao Xu and Xiao-Qin Xu and Yu Wang and Xu-Qing Wang and Hai-Bo Yang and Wei Wang}, doi = {10.1002/anie.202412548}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412548}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Lighting up bispyrene-functionalized chiral molecular muscles with switchable circularly polarized excimer emissions}, volume = {64}, year = {2025}, }
• (2025). Antioxidative therapy of alcoholic liver injury by amorphous two-dimensional cobalt hydroxide nanocatalyst. ANGEW, 64(1), e202412031. (www)

  @article{ , abstract = {The intake of excessive ethanol will activate an alternative ethanol metabolic pathway in the liver, resulting in the overproduction of reactive oxygen species (ROS), which further leads to alcoholic liver injury (ALI). Although several molecular antioxidants have been utilized in clinics for treating ALI, their efficacies are still less satisfactory. In this work, a nanocatalytic antioxidation therapeutic strategy is proposed for ALI treatment by constructing amorphous Co(OH) 2 nanosheets with catalytic antioxidative property. The bis( μ -hydroxo)Co II Co II dinuclear active sites of Co(OH) 2 nanosheets are capable of coordinating with hydrogen peroxide (H 2 O 2 ) with significantly reduced thermodynamic barrier to form a dihydroxyl adduct bis( μ -hydroxo)Co III (OH)Co III (OH) favorable for catalytic H 2 O 2 disproportionation, while amorphous and ultrathin structure further facilitates the reaction, resulting in a high catalytic efficiency ( K m =59.31 mM). Thanks to the inherent hepatic passive targeting ability of nanomaterials, the antioxidative nanosheets can accumulate in liver region efficiently after intravenous administration (35.5 % ID/g accumulation efficiency), enabling efficient catalytic antioxidation in the liver to mitigate hepatic oxidative stress, protect hepatocytes from apoptosis/ferroptosis. This study provides a new methodology of nanocatalytic antioxidation for treating ALI and other hepatic diseases related to oxidative stress.}, archive = {J_ANGEW}, author = {Di Jiang and Bowen Yang and Jianlin Shi}, doi = {10.1002/anie.202412031}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202412031}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Antioxidative therapy of alcoholic liver injury by amorphous two-dimensional cobalt hydroxide nanocatalyst}, volume = {64}, year = {2025}, }
• (2025). Reply to correspondence on “Unlocking the chain-walking process in gold catalysis”. ANGEW, 64(1), e202411948. (www)

  @article{ , abstract = {We recently reported the gold-catalyzed Heck and chain-walking reactions, which utilize migratory insertion, β -hydride elimination steps in a catalytic fashion. Budzelaar et al. in their correspondence state that these reactions proceed through gold-catalyzed alkene heteroarylation followed by acid-mediated elimination and cyclization sequence. In response to this correspondence, we have conducted some experiments which convinced us that the product formation solely can not be rationalized based on hetero-arylation of alkenes under ligand-enabled Au(I)/Au(III) catalysis.}, archive = {J_ANGEW}, author = {Vivek W. Bhoyare and E. Daiann Sosa Carrizo and Vincent Gandon and Nitin T. Patil}, doi = {10.1002/anie.202411948}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202411948}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Reply to correspondence on “Unlocking the chain-walking process in gold catalysis”}, volume = {64}, year = {2025}, }
• (2025). Thermally assisted microfluidics to produce chemically equivalent microgels with tunable network morphologies. ANGEW, 64(1), e202411772. (www)

  @article{ , abstract = {Although micron-sized microgels have become important building blocks in regenerative materials, offering decisive interactions with living matter, their chemical composition mostly significantly varies when their network morphology is tuned. Since cell behavior is simultaneously affected by the physical, chemical, and structural properties of the gel network, microgels with variable morphology but chemical equivalence are of interest. This work describes a new method to produce thermoresponsive microgels with defined mechanical properties, surface morphologies, and volume phase transition temperatures. A wide variety of microgels is synthesized by crosslinking monomers or star polymers at different temperatures using thermally assisted microfluidics. The diversification of microgels with different network structures and morphologies but of chemical equivalence offers a new platform of microgel building blocks with the ability to undergo phase transition at physiological temperatures. The method holds high potential to create soft and dynamic materials while maintaining the chemical composition for a wide variety of applications in biomedicine.}, archive = {J_ANGEW}, author = {Dirk Rommel and Bernhard Häßel and Philip Pietryszek and Matthias Mork and Oliver Jung and Meike Emondts and Nikita Norkin and Iris Christine Doolaar and Yonca Kittel and Ghazaleh Yazdani and Abdolrahman Omidinia-Anarkoli and Sjören Schweizerhof and Kyoohyun Kim and Ahmed Mourran and Martin Möller and Jochen Guck and Laura De Laporte}, doi = {10.1002/anie.202411772}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202411772}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Thermally assisted microfluidics to produce chemically equivalent microgels with tunable network morphologies}, volume = {64}, year = {2025}, }
• (2025). Designable electrochemiluminescence patterning for renewable and enhanced bioimaging. ANGEW, 64(1), e202410825. (www)

  @article{ , abstract = {Electrochemical imaging enables an in-depth analysis of the interface heterogeneity and reaction kinetics of single entities. However, electrode passivation during electrochemical reactions decreases the active sites and harms the long-term stability. Here, we introduce a method using laser-induced photothermal effects to restore the electrochemical activity, which is particularly displayed as enhanced micrometric patterns in electrochemiluminescence (ECL) microscopy. By co-localization characterization and X-ray photoelectron spectroscopy (XPS), the mechanism of active site regeneration is validated as the removal of the oxide film for restoring the local surface ECL reactivity under laser irradiation. The surface-confined and voltage-dependent features of ECL allows for easy pattern erasure and rewriting, and it shows good reversibility and anti-counterfeiting potential. This approach overcomes the passivation processes, evidently improves the image quality of single biological entities including Shewanella bacteria and cells, and makes the subtle contour structures more distinct. The renewable electrode interface also enhances the ECL signal of model bead-based bioassays. This approach not only showcases precise control in fabricating micron patterns but also holds promise for enhancing the sensitivity in electrochemical immunoassays and bioimaging.}, archive = {J_ANGEW}, author = {Xiaodan Gou and Zejing Xing and Zhichen Zhang and Rong Jin and Qin Xu and Neso Sojic and Jun-Jie Zhu and Cheng Ma}, doi = {10.1002/anie.202410825}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202410825}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Designable electrochemiluminescence patterning for renewable and enhanced bioimaging}, volume = {64}, year = {2025}, }
• (2025). Internal electron-donation allocation design for intrinsic solubilization of lithium nitrate in ester electrolyte for stable lithium metal batteries. ANGEW, 64(1), e202410020. (www)

  @article{ , abstract = {Lithium metal batteries (LMBs) have become a hot topic in the research of next-generation advanced battery technology due to their high specific energy. However, the high reaction activity between lithium metal and electrolyte is considered one of the key bottlenecks limiting large-scale applications of LMBs. As a classic electrolyte additive, lithium nitrate (LiNO 3 ) significantly improves the stability of lithium metal in ether-based electrolytes. However, its solubility in carbonate-based electrolytes widely used in lithium-ion batteries is extremely low, causing limited protective capability on lithium metal, which has become a key obstacle to the commercial application of lithium metal batteries. Here, we enhanced the local negative charge density of carbonyl oxygen atoms in carbonate molecules by introducing electron donors, making it easier for them to coordinate with Li + , thereby weakening the interaction between Li + and NO 3 − , and significantly increasing the solubility of LiNO 3 in ester electrolytes. The modified ester solvent promotes the derivatization and decomposition of salt anions, leading to the formation of a dense SEI layer rich in LiF and LiN x O y . This significantly improves the stability of lithium metal in ester-based electrolytes. The assembled Li||Li symmetric battery shows excellent cycling performance of over 4000 hours.}, archive = {J_ANGEW}, author = {Sheng Gu and Yu Zhang and Meng Li and Qianru Lin and Guoqi Xu and Naiqing Zhang}, doi = {10.1002/anie.202410020}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202410020}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Internal electron-donation allocation design for intrinsic solubilization of lithium nitrate in ester electrolyte for stable lithium metal batteries}, volume = {64}, year = {2025}, }
• (2025). Resolving structures of paramagnetic systems in chemistry and materials science by solid-state NMR: The revolving power of ultra-fast MAS. ANGEW, 64(1), e202408704. (www)

  @article{ , abstract = {Ultra-fast magic-angle spinning (100+kHz) has revolutionized solid-state NMR of biomolecular systems but has so far failed to gain ground for the analysis of paramagnetic organic and inorganic powders, despite the potential rewards from substantially improved spectral resolution. The principal blockages are that the smaller fast-spinning rotors present significant barriers for sample preparation, particularly for air/moisture-sensitive systems, and are associated with low sensitivity from the reduced sample volumes. Here, we demonstrate that the sensitivity penalty is less severe than expected for highly paramagnetic solids and is more than offset by the associated improved resolution. While previous approaches employing slower MAS are often unsuccessful in providing sufficient resolution, we show that ultra-fast 100+kHz MAS allows site-specific assignments of all resonances from complex paramagnetic solids. Combined with more reliable rotor materials and handling methods, this opens the way to the routine characterization of geometry and electronic structures of functional paramagnetic systems in chemistry, including catalysts and battery materials. We benchmark this approach on a hygroscopic luminescent Tb 3+ complex, an air-sensitive homogeneous high-spin Fe 2+ catalyst, and a series of mixed Fe 2+ /Mn 2+ /Mg 2+ olivine-type cathode materials.}, archive = {J_ANGEW}, author = {Jonas Koppe and Kevin J. Sanders and Thomas C. Robinson and Arthur L. Lejeune and David Proriol and Sebastian Wegner and Armin Purea and Frank Engelke and Raphaële J. Clément and Clare P. Grey and Andrew J. Pell and Guido Pintacuda}, doi = {10.1002/anie.202408704}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202408704}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Resolving structures of paramagnetic systems in chemistry and materials science by solid-state NMR: The revolving power of ultra-fast MAS}, volume = {64}, year = {2025}, }
• (2025). Discovery and total synthesis of anhydrotuberosin as a STING antagonist for treating autoimmune diseases. ANGEW, 64(1), e202407641. (www)

  @article{ , abstract = {Excessive activation of the stimulator of the interferon gene (STING) pathway has been identified as a significant contributor to various autoimmune diseases, such as STING-associated vasculopathy with infantile-onset (SAVI) and inflammatory bowel disease (IBD). However, discovering effective STING antagonists for treating STING-mediated autoimmune disorders remains challenging. Herein, we identified the natural product anhydrotuberosin (ATS) as a potent STING antagonist by a high-throughput chemical screen and follow-up biological validations. However, the limited supply from natural product isolation impeded the pharmacological evaluations of ATS. Accordingly, we developed a concise and scalable total synthesis of ATS in 6 steps. Enabled by total synthesis, we further extensively investigated ATS's mode of action and evaluated its therapeutic potential. Remarkably, ATS inhibits STING signaling in PBMCs derived from three SAVI patients. ATS showed decent pharmacokinetic parameters and strongly alleviated tissue inflammation in DSS-induced IBD colitis and Trex1 -/- autoimmune animal models with low toxicity. Collectively, this research lays the foundation for developing novel STING antagonists as an effective therapy for autoinflammatory and autoimmune diseases.}, archive = {J_ANGEW}, author = {Fusheng Guo and Jing Zhang and Yihui Gao and Zhou Shu and Fei Sun and Jing Ma and Xu Zhou and Wenyang Li and Huawei Mao and Xiaoguang Lei}, doi = {10.1002/anie.202407641}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202407641}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Discovery and total synthesis of anhydrotuberosin as a STING antagonist for treating autoimmune diseases}, volume = {64}, year = {2025}, }
• (2025). Karl ziegler – Early career of a scientist. ANGEW, 64(1), e202403180. (www)

  @article{ , abstract = {Karl Ziegler is considered one of the most outstanding chemists of the 20th century. In particular, his work on organometallic mixed catalysts, which allows the polymerization of ethylene at normal pressure, led to a revolution in plastics production and changed the everyday life of all mankind. In 1963, he was awarded the Nobel Prize in Chemistry for this work, together with Giulio Natta. This article focuses on Ziegler's early career, which has received little attention to date. It describes his youth and study years in Marburg, which partly coincide with the First World War. Subsequently, his postdoctoral period is examined, which led him via Marburg and Frankfurt to his first associate professorship in Heidelberg. Special attention is paid to his relationship to National Socialism, which he opposed. As a result, Ziegler experienced professional difficulties in the 1930s, such as repeated rejection when filling various professorships. His appointment as a full professor in Halle and his subsequent directorship at the Max-Planck-Institut für Kohlenforschung (Coal Research), where he finally achieved his greatest research achievement, are described in the following.}, archive = {J_ANGEW}, author = {Christoph Kießling}, doi = {10.1002/anie.202403180}, journal = {Angewandte Chemie International Edition}, month = {1}, number = {1}, pages = {e202403180}, shortjournal = {Angew. Chem. Int. Edit.}, title = {Karl ziegler – Early career of a scientist}, volume = {64}, year = {2025}, }